LOCUS 004_Delta4_auf_Barbe 3983870 bp DNA circular CON 12-JAN-2021 DEFINITION Bacillus subtilis subsp. subtilis str. 168 complete genome. ACCESSION NC_000964 DBLINK BioProject: PRJNA76 BioSample: SAMEA3138188 KEYWORDS RefSeq; complete genome. SOURCE Bacillus subtilis subsp. subtilis str. 168 ORGANISM Bacillus subtilis subsp. subtilis str. 168 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. REFERENCE 1 AUTHORS Borriss,R., Danchin,A., Harwood,C.R., Medigue,C., Rocha,E.P.C., Sekowska,A. and Vallenet,D. TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement JOURNAL Microb Biotechnol 11 (1), 3-17 (2018) PUBMED 29280348 REFERENCE 2 (bases 1 to 4215606) AUTHORS Belda,E., Sekowska,A., Le, Fevre,F., Morgat,A., Mornico,D., Ouzounis,C., Vallenet,D., Medigue,C. and Danchin,A. TITLE An updated metabolic view of the Bacillus subtilis 168 genome JOURNAL Microbiology (Reading, Engl.) 159 (Pt 4), 757-770 (2013) PUBMED 23429746 REFERENCE 3 (bases 1 to 4215606) AUTHORS Barbe,V., Cruveiller,S., Kunst,F., Lenoble,P., Meurice,G., Sekowska,A., Vallenet,D., Wang,T., Moszer,I., Medigue,C. and Danchin,A. TITLE From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later JOURNAL Microbiology (Reading, Engl.) 155 (Pt 6), 1758-1775 (2009) PUBMED 19383706 REFERENCE 4 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G., Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S., Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C., Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V., Carter,N.M., Choi,S.K., Cordani,J.J., Connerton,I.F., Cummings,N.J., Daniel,R.A., Denziot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D., Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E., Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A., Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J., Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R., Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F., Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y., Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P., Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A., Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H., Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P., Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M., Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M., Portelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P., Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M., Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T., Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J., Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B., Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K., Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Togoni,A., Tosato,V., Uchiyama,S., Vandebol,M., Vannier,F., Vassarotti,A., Viari,A., Wambutt,R., Wedler,H., Weitzenegger,T., Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K., Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and Danchin,A. TITLE The complete genome sequence of the gram-positive bacterium Bacillus subtilis JOURNAL Nature 390 (6657), 249-256 (1997) PUBMED 9384377 REFERENCE 5 (bases 1 to 4215606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (17-SEP-2018) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM AMAbiotics and Genoscope TITLE Direct Submission JOURNAL Submitted (24-JAN-2013) A. Danchin, AMAbiotics, Bldg G1, 2, rue Gaston Cremieux, 91000 EVRY antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA (Commissariat a l'energie atomique et aux energies alternatives): BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr - Web: www.genoscope.cns.fr) REFERENCE 7 (bases 1 to 4215606) AUTHORS Genoscope and -,C.E.A. CONSRTM Institut Pasteur and Genoscope TITLE Direct Submission JOURNAL Submitted (29-JAN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr) REFERENCE 8 (bases 1 to 4215606) AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A. TITLE Direct Submission JOURNAL Submitted (18-NOV-1997) I. Moszer, A. Danchin, Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail: moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1 45 68 84 41, Fax: +33 (0)1 45 68 89 48 COMMENT ##gff-version-START## gff-version :: 3 ##gff-version-END## FEATURES Location/Qualifiers S_feature 1..148 /Source="Nicolas_S_feature" /locus_tag="new_1_148" /HighExp="T0.30H, C30, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, S2, T-1.10H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1" S_feature complement(24..297) /Source="Nicolas_S_feature" /locus_tag="new_24_297_c" /HighExp="S8, C30, Etha, S3, S7, S4, Cold, BT, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.178448" /TUshortSig="SigK, SigEF" /TUshortPSig="0.621, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S2" promotor_-35 120..124 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-35" promotor_-10 140..159 /Source="Nicolas_upshift_promotors" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" /label="promotor_-10" S_feature 150..409 /Source="Nicolas_S_feature" /locus_tag="new_150_409" /HighExp="Heat, G180, LPhT, G150, dia15, Oxctl, S1, G135, LBGstat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S3" upshifts 150 /Source="Nicolas_upshifts" /id="U1" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=2521 /SigmaFactorBS="tgtccgctttgtggataagattgtgacaacCATTGcaagctc tcgtttatTTTGGTATTATATTTGTGTTttaactcttgattactaatcctacctttcc t" /listShort="S3, dnaA, S5, dnaN, yaaA, recF" /listLong="yaaB, gyrB, S6, gyrA" promotor_-10 complement(285..304) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(297) /Source="Nicolas_upshifts" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" S_feature complement(299..1067) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" promotor_-35 complement(318..326) /Source="Nicolas_upshift_promotors" /id="U2" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.621378621378621" /psig="0.621378621378621" /xcortree=272 /SigmaFactorBS="aacacaaaaaaagagcaaatggcgcttaccaTTCGTACACat taaatgttgaaAACATATAATATAGTAGATAaatagcttttcgacaaatttcacaact t" /listShort="S2" /GFF_Attribute="listLong" /label="promotor_-35" CDS 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" gene 410..1750 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" promotor_-10 complement(1040..1058) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" promotor_-35 complement(1074..1079) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1751..1938 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" gene 1939..3075 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" downshifts 3059 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" promotor_-35 3140..3144 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161..3180 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3169 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" gene 3206..3421 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" CDS 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" gene 3437..4549 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" misc_feature 3635..3654 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3653 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" CDS 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" gene 4567..4812 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" CDS 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" gene 4867..6783 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" promotor_-10 complement(6412..6430) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6414) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(6446..6451) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6784..6993 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" gene 6994..9459 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" promotor_-35 9373..9376 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9374 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9393..9410 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9440 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" promotor_-35 9504..9510 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9524..9543 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9529..9614 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9529 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" promotor_-35 9600..9607 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9616 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 9622..9641 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 9810..11364 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" tRNA 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11464..11540 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" tRNA 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11552..11627 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" rRNA 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 11709..14636 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" rRNA 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 14692..14810 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" S_feature 14811..15868 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" gene complement(14847..15794) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" promotor_-35 15847..15854 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15869..15888 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15870 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" upshifts complement(15875) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" promotor_-10 complement(15884..15895) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15909..15915) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" gene 15915..17381 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" downshifts complement(15919) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(15945..16045) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15985) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(17238..17833) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 17369 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" promotor_-35 17427..17431 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17447..17466 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17453..17533 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17453 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" gene 17534..18865 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" promotor_-10 complement(17822..17840) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17833) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" promotor_-35 complement(17855..17861) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18747 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" S_feature 18866..18974 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18944..18947 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18962..18981 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18976..19061 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18976 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" CDS 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" gene 19062..19946 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" S_feature complement(19194..19923) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19911..19929) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19923) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" promotor_-35 complement(19945..19950) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" gene 19968..20558 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" misc_RNA 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene 20611..20823 /gene="tboS" /locus_tag="BSU_misc_RNA_1" downshifts 20788 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" CDS 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" gene 20880..22157 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" downshifts 22135 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" promotor_-35 22246..22253 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 22268..22287 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 22268 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" tRNA 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 22292..22384 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" downshifts 22407 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" S_feature 22452..22529 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " gene complement(22496..23149) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" promotor_-35 22515..22521 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22520) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" S_feature 22531..23167 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22531 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 22535..22546 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" gene complement(23146..23769) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" promotor_-10 complement(23810..23829) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23828) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" promotor_-35 complement(23845..23849) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" gene complement(23868..25151) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" downshifts complement(23905) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(25182..25200) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25203) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25216..25221) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" gene complement(25221..25766) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" promotor_-35 25632..25636 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25651..25670 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25655..25851 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25657 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" promotor_-10 complement(25791..25809) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25810) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" promotor_-35 complement(25824..25830) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" gene 25852..26337 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" promotor_-35 26341..26347 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" gene 26379..26732 /gene="scr" /locus_tag="BSU_misc_RNA_2" S_feature 26383..26532 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 26383 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" S_feature 26636..26731 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26688 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" promotor_-35 26752..26755 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26770..26789 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26779 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" gene 26814..28505 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" promotor_-35 28346..28353 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 28368..28387 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 28383 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" CDS 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" gene 28529..28852 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" CDS 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" gene 28867..29463 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" CDS 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" gene 29481..29705 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" promotor_-35 29708..29713 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29725 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" promotor_-10 29729..29747 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" gene 29772..30035 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" promotor_-35 30048..30055 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 30069..30088 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 30076..30278 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 30076 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" rRNA 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 30279..31832 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" tRNA 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 31932..32008 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" tRNA 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32020..32095 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" rRNA 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 32177..35103 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" S_feature 35104..35236 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 35237..35355 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" S_feature 35356..35458 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35419..35427 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35441..35460 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35460 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" CDS 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" gene 35531..35725 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" downshifts 35709 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" promotor_-35 35770..35779 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35791..35806 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35797 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" gene 35845..36459 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" CDS 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" gene 36478..37638 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" S_feature 37639..37719 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" gene 37720..39162 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" promotor_-35 39082..39088 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 39103..39121 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 39112 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" CDS 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" gene 39159..39797 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" promotor_-35 39792..39799 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39812..39831 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39823 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" CDS 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" gene 39871..40200 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" CDS 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" gene 40213..40653 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" CDS 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" gene 40665..41654 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" CDS 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " gene 41657..42484 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" CDS 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" gene 42499..42858 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" CDS 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" gene 42917..43660 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" CDS 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" gene 43647..43946 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" CDS 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" gene 43921..44799 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" downshifts 44772 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" CDS complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" gene complement(44848..45138) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" downshifts complement(44850) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" downshifts 45169 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" promotor_-10 complement(45205..45224) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45222) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" S_feature complement(45224..45399) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(45238..45245) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(45395..45414) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(45399) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" promotor_-35 complement(45428..45435) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45499..45503 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45518..45537 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45524..45632 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45524 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" CDS 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" gene 45633..47627 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" promotor_-10 complement(46381..46400) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(46389) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(46416..46420) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47611 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" S_feature complement(47673..50019) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" gene 47706..48473 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" S_feature 48474..48554 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48531..48536 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48552..48570 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48556 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-35 48581..48584 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48599..48618 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48616 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" CDS 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" gene 48629..49942 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" promotor_-35 48649..48656 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48667 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 48671..48690 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49903 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" promotor_-35 49965..49969 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49985..50004 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49987..50086 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49987 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" promotor_-10 complement(50011..50026) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(50027) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" promotor_-35 complement(50038..50047) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 50083..50099 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" gene 50087..50647 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" upshifts 50097 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" CDS 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" gene 50640..51518 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" downshifts 51483 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" promotor_-35 51533..51542 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51556..51575 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51558..51679 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51558 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" CDS 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" gene 51680..52552 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" downshifts 52539 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" S_feature 52649..52719 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52710..52717 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52721 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" promotor_-10 52731..52750 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52740..52754) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52747) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(52763..52767) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" gene 52763..53023 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" downshifts 52935 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" downshifts 53022 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" promotor_-35 53088..53094 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 53108..53119 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 53111..53182 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 53111 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" CDS 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" gene 53183..53368 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" downshifts 53353 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" S_feature complement(53363..55717) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53446..53450 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53466..53485 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53469 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" CDS 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" gene 53516..54385 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" CDS 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" gene 54441..55298 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" CDS 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" gene 55295..55672 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" downshifts 55662 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" promotor_-10 complement(55706..55724) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55707..55815 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55718) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" promotor_-35 complement(55740..55745) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55795..55803 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55814..55832 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55817 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" CDS 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" gene 55866..56159 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" downshifts 56148 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" S_feature 56193..56304 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 56286..56290 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 56306..56325 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 56306 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" gene 56352..57722 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" downshifts complement(57697) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" CDS 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" gene 57745..58698 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" promotor_-35 58711..58717 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58730 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" promotor_-10 58732..58750 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" gene 58783..59397 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" downshifts 59381 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" CDS 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" gene 59504..60070 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" misc_feature 59683..59686 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59689 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" CDS 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" gene 60130..60360 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" S_feature 60361..60429 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" gene 60430..63963 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" promotor_-35 63981..63987 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 64001..64098 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 64001..64012 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 64001 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" CDS 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" gene 64099..64635 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" downshifts 64639 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" misc_feature 64735..64754 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64746 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" CDS 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" gene 64817..66415 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" promotor_-35 66286..66293 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 66308..66327 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 66322 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" CDS 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" gene 66405..67874 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" promotor_-35 67046..67053 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 67067..67085 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 67081 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" promotor_no_box complement(67469..67569) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67509) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" gene 67877..68137 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" promotor_-35 68142..68147 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68163..68181 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68181 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" downshifts complement(68213) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" CDS 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" gene 68216..68518 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" CDS 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" gene 68515..69150 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" promotor_-35 69020..69029 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69042..69057 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69044 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" promotor_-35 69076..69084 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69095..69113 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69105 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" CDS 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" gene 69168..69545 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" CDS 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" gene 69626..70012 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" downshifts 70006 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" promotor_-35 70120..70127 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 70141..70160 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 70156 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" tRNA 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70181..70257 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" tRNA 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 70267..70338 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" downshifts 70337 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" S_feature 70382..70493 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70489..70508 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70495 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" CDS 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" gene 70538..73021 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" downshifts 70579 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" S_feature complement(71190..71799) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(71216) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" promotor_-10 complement(71772..71790) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71798) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" promotor_-35 complement(71806..71811) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 72003..72009 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72024..72042 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72031 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" promotor_-35 73041..73044 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 73062..73079 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 73065 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" CDS 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" gene 73106..73843 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" CDS 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" gene 73809..74825 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" promotor_-35 74357..74363 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 74379..74397 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 74385 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" promotor_-35 74855..74862 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74876..74895 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74886 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" gene 74929..76347 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" promotor_-35 75724..75731 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75746..75765 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75749 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" downshifts complement(76342) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" CDS 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" gene 76344..76886 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" upshifts complement(76749) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(76751..76755) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76773..76776) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76887..76983 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" gene 76984..78897 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" downshifts 78895 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" misc_feature complement(78934..78938) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78940..79025 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78942) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 79002..79009 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 79023..79042 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 79027..79091 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 79027 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" gene 79092..79868 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" CDS 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" gene 79880..80755 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" CDS 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" gene 80802..81695 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" promotor_-35 81425..81430 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81447..81465 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81448 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 81694..81701 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81716..81735 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81723 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" CDS 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" gene 81771..82697 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" downshifts 82690 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" promotor_-35 82744..82752 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82766..82774 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82768 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 82796..82799 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82814..82833 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82824 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" gene 82864..84276 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" promotor_-35 83666..83668 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83686..83704 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83692 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" promotor_-35 84033..84040 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 84053..84072 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 84066 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" CDS 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" gene 84290..84874 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" CDS 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" gene 84874..85755 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" CDS 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" gene 85737..86594 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" CDS 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" gene 86587..86949 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" CDS 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" gene 86946..87449 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" CDS 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" gene 87401..87610 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" CDS 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " gene 87634..88635 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" S_feature complement(88050..89566) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88636..88726 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" gene 88727..90226 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" promotor_-10 complement(89550..89568) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89566) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" promotor_-35 complement(89584..89589) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 90207 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" promotor_-35 90302..90309 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 90318..90535 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 90318 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" promotor_-10 90323..90342 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(90368) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" rRNA 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 90536..92089 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" rRNA 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 92254..95181 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" rRNA 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95237..95354 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" tRNA 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95375..95450 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" tRNA 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95455..95530 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" tRNA 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95567..95642 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" tRNA 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95649..95731 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" tRNA 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95772..95846 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" tRNA 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 95861..95946 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" tRNA 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene 95956..96032 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" tRNA 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96060..96136 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" tRNA 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96146..96221 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" rRNA 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 96392..97945 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" rRNA 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 98110..101037 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" rRNA 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 101093..101211 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" S_feature 101212..101289 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 101259..101262 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101278..101297 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101291 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-35 101325..101331 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 101345..101364 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 101356 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" promotor_-35 101371..101378 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 101392..101411 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 101404 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" gene 101449..101913 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" misc_feature complement(101560..101564) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101566) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" gene 101927..102484 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" CDS 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" gene 102484..103575 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" CDS 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" gene 103572..106004 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" downshifts 105999 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" CDS 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" gene 106096..107472 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" promotor_-35 106551..106560 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106573..106588 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106576 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" gene 107476..108558 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" S_feature 108559..108673 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" gene 108674..109774 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" downshifts complement(109596) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" CDS 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" gene 109789..110487 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" CDS 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" gene 110480..110956 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" promotor_-35 110960..110967 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110981..111000 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110994 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" gene 111047..112498 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" promotor_-35 111976..111985 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111999..112018 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111999 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" S_feature 112499..112799 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " gene 112800..113453 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" CDS 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" gene 113450..114850 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" CDS 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" gene 114854..115285 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" CDS 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" gene 115269..116018 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" CDS 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" gene 116025..116537 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" promotor_-35 116536..116543 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116558..116577 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116560 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" gene 116600..117256 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" downshifts complement(117054) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" S_feature 117257..117348 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" gene 117349..117498 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" CDS 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" gene 117532..117711 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" S_feature 117712..117889 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117883) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" CDS 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" gene 117890..118423 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" upshifts complement(117978) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(117981..117985) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(118000..118005) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118434..118441 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118452..118590 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118452 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 118455..118474 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" gene 118591..119016 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" S_feature 119017..119110 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" gene 119111..119809 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" downshifts complement(119783) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" misc_RNA 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" gene 119855..119995 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" upshifts complement(119871) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(119874..119878) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119927 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" CDS 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" gene 120061..120561 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" CDS 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" gene 120607..120978 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" downshifts 120894 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" downshifts 120967 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" CDS 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" gene 121068..121673 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" promotor_-35 121668..121672 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121686..121918 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121686 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 121688..121707 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" gene 121919..125500 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" promotor_-10 complement(123504..123523) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123507) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(123537..123546) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(124375..124379) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(124380) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(124394..124400) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" gene 125562..129161 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" downshifts complement(128626) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" upshifts complement(128780) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(128798..128799) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(129110) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" S_feature 129162..129283 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 129265..129272 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 129285 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" promotor_-10 129286..129305 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(129303..129307) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(129306) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" gene 129340..129588 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" S_feature 129589..129701 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" gene 129702..130118 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" CDS 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" gene 130160..130630 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" CDS 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" gene 130684..132762 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" S_feature 132763..132881 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" gene 132882..134072 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" downshifts 134067 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" misc_feature complement(134098..134101) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(134102) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 134128..134147 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 134136 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" CDS 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" gene 134171..135127 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" promotor_-35 135134..135141 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 135155..135174 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 135170..135363 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 135170 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" CDS 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" gene 135364..135672 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" CDS 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" gene 135712..136341 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" CDS 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" gene 136369..136992 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" CDS 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" gene 136992..137279 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" CDS 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" gene 137311..138144 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" downshifts complement(137447) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" CDS 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" gene 138202..138480 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" CDS 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" gene 138497..138838 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" CDS 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" gene 138842..139498 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" downshifts complement(138855) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(138936..138940) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138943) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(138957..138959) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" gene 139500..139934 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" CDS 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" gene 139924..140124 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" CDS 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" gene 140147..140410 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" CDS 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" gene 140451..140819 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" CDS 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" gene 140857..141168 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" CDS 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" gene 141195..141734 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" CDS 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" gene 141757..141942 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" CDS 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" gene 141974..142372 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" downshifts complement(142375) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" CDS 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" gene 142402..142941 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" CDS 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" gene 142974..143336 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" CDS 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" gene 143361..143861 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" CDS 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" gene 143875..144054 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" CDS 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" gene 144085..144525 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" CDS 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" gene 144527..145822 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" CDS 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " gene 145877..146530 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" CDS 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" gene 146527..147273 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" CDS 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" gene 147312..147536 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" CDS 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" gene 147585..147803 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" CDS 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" gene 147837..147950 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" CDS 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" gene 147973..148338 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" CDS 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" gene 148359..148754 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" S_feature 148755..148930 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" gene 148931..149875 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" CDS 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" gene 149953..150315 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" downshifts 150317 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" S_feature 150362..150442 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" gene 150443..151288 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" CDS 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" gene 151303..152133 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" CDS 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" gene 152130..152927 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" CDS 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" gene 152937..153680 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" S_feature complement(153039..153507) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 153172..153177 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153192..153209 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153211 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" promotor_-10 complement(153507..153526) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153529) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" promotor_-35 complement(153539..153548) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153700..153706 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153721..153740 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153725 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" misc_RNA 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" gene 153737..153793 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" CDS 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" gene 153842..154279 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" CDS 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" gene 154300..154692 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" downshifts 154667 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" promotor_-35 154809..154816 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154830..154849 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154838..155119 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154838 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" misc_feature 155118..155137 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 155121 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" CDS 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" gene 155156..155923 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" downshifts 155914 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" promotor_-35 156053..156059 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156074..156085 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156081 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" CDS 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" gene 156109..156552 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" promotor_-35 156552..156557 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156573..156591 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156574 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" CDS 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" gene 156612..157325 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" upshifts 157370 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" misc_feature 157373..157392 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" gene 157421..158479 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" S_feature complement(158050..158514) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158465 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" S_feature 158510..159181 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" gene complement(158515..159072) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" promotor_-10 complement(159104..159115) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(159116) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" promotor_-35 complement(159129..159135) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(159149..159778) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" gene 159182..159778 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" S_feature 159779..160673 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" gene complement(159779..160543) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" promotor_-10 complement(160574..160592) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160594) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" promotor_-35 complement(160608..160613) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160651..160658 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160673..160692 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160675..160892 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160675 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" rRNA 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 160893..162445 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" rRNA 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 162610..165535 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" rRNA 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165591..165707 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" tRNA 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165754..165825 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" tRNA 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165830..165902 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" tRNA 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 165959..166033 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" tRNA 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166064..166140 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" tRNA 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166168..166244 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" tRNA 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166253..166328 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" rRNA 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 166500..168053 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" rRNA 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 168218..171141 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" rRNA 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171197..171314 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" rRNA 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 171498..173049 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" rRNA 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 173214..176141 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" rRNA 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 176197..176315 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" S_feature 176316..176924 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176892..176896 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176912..176931 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176926..177082 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176926 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" CDS 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" gene 177083..178519 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" downshifts 178508 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" promotor_-35 178562..178567 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178580..178599 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178598 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" CDS 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" gene 178665..179585 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" downshifts 179566 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" CDS complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" gene complement(179595..180347) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" downshifts complement(179619) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" CDS complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" gene complement(180344..181354) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" CDS complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" gene complement(181347..182351) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" CDS complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" gene complement(182370..183323) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" promotor_-35 182683..182689 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182704..182722 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182713 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(183354..183373) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(183361) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" CDS complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" gene complement(183414..185003) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" promotor_-10 complement(185044..185063) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(185056) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" promotor_-35 complement(185078..185085) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(185165) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" CDS complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" gene complement(185194..186438) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" downshifts complement(185215) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" CDS complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" gene complement(186452..188380) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" CDS complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" gene complement(188408..189733) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" CDS complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" gene complement(189790..191157) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" CDS complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" gene complement(191183..192034) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" CDS complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" gene complement(192051..192965) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" promotor_-10 complement(192996..193014) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193009) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" promotor_-35 complement(193030..193037) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" gene complement(193075..193557) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" CDS complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" gene complement(193570..194025) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" promotor_-10 complement(194051..194070) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(194072) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" promotor_-35 complement(194085..194086) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 194145..194152 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 194167..194186 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 194178 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" tRNA 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194205..194279 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" tRNA 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194283..194358 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" tRNA 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194363..194435 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" tRNA 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194458..194542 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" tRNA 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 194547..194621 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" downshifts 194624 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" S_feature 194669..194786 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194787..194796 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194788 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" promotor_-10 194808..194823 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" gene 194849..195412 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" CDS 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" gene 195426..196052 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" downshifts complement(195844) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(196002..196102) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 196032 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" upshifts complement(196042) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 196101..196108 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 196123..196142 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 196132..196212 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 196132 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" CDS 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" gene 196213..197034 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" CDS 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" gene 197027..198478 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" CDS 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" gene 198497..199843 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" downshifts 199838 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" promotor_-35 199862..199870 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199878 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" promotor_-10 199884..199903 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199930..199935 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199951..199970 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199957 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_feature 200001..200017 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 200014 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" misc_RNA 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" gene 200017..200187 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" S_feature 200188..200276 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" gene 200277..202079 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" S_feature complement(201802..>202082) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 202065 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" SCAR join(202082,202128) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 202083..202127 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <202128..202246 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" gene 202247..203224 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" CDS 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" gene 203226..203897 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" promotor_-35 203791..203797 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203811..203830 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203829 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" CDS 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" gene 203918..204880 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" promotor_-35 204892..204894 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204910..204929 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204913 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" CDS 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" gene 204939..205202 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" downshifts 205143 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" CDS complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" gene complement(205187..205957) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" CDS complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" gene complement(206043..206900) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" downshifts complement(206065) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(206114..206133) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(206147..206156) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(206149) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(206913..206932) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206938) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" promotor_-35 complement(206947..206954) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206968..206975 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206989..207007 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206991 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" CDS 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" gene 207032..208216 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" downshifts 208202 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" promotor_-35 208370..208376 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 208390..208409 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208404..208533 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208404 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" CDS 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" gene 208534..209922 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" downshifts 209930 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" promotor_-35 209968..209974 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209988..209999 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209989 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" CDS 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" gene 210034..210282 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" CDS 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" gene 210299..210490 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" downshifts 210472 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" CDS complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" gene complement(210517..211320) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" promotor_-10 complement(211342..211360) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(211350) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" promotor_-35 complement(211371..211379) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211434..211440 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211455..211473 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211461 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" CDS 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" gene 211493..212746 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" misc_feature 211805..211812 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211815 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 212739 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" CDS complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" gene complement(212787..213047) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" downshifts complement(212806) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" promotor_-10 complement(213077..213095) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(213086) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" promotor_-35 complement(213109..213115) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 213239..213246 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 213256 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" promotor_-10 213262..213281 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" gene 213316..214935 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" downshifts 214918 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" CDS complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" gene complement(214982..215863) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" downshifts complement(214993) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" upshifts complement(215906) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" promotor_-10 complement(215915..215931) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215940..215946) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" gene complement(215962..217296) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" promotor_-35 216944..216953 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216966..217592 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216966..216985 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216966 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" S_feature complement(217297..217369) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(217329..217429) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(217369) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" S_feature complement(217371..217457) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217447..217466) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217461) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" promotor_-35 complement(217479..217486) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" gene 217593..217841 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" promotor_-35 217865..217872 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217872 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" promotor_-10 217888..217907 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" gene 217933..218850 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" CDS 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" gene 218847..220097 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" downshifts 220087 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" CDS complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" gene complement(220132..220416) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo downshifts complement(220185) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" CDS complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" gene complement(220322..220444) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo S_feature complement(220417..220537) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220522..220540) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220537) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" S_feature complement(220539..220611) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220557..220562) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" gene complement(220612..221523) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" S_feature complement(221524..221611) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" gene complement(221612..223810) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" misc_feature complement(223845..223863) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223857) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" CDS complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" gene complement(223885..224805) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" CDS complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " gene complement(224802..225629) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" misc_feature complement(225656..225675) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225663) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" promotor_-35 225803..225806 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225821..225840 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225826 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" CDS 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" gene 225860..227014 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" downshifts 226995 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" promotor_-35 227075..227080 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 227089 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" promotor_-10 227095..227113 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 227129..227136 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 227151..227170 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 227151 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" CDS 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" gene 227158..228099 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" CDS 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" gene 228062..228460 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" promotor_-10 complement(228154..228168) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(228164) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(228184..228189) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228447 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" promotor_-35 228516..228523 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228538..228557 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228551..228625 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228551 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" CDS 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" gene 228626..229516 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" promotor_-35 228860..228867 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228876 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" promotor_-10 228881..228899 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229517..229711 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" gene 229712..230245 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" CDS 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" gene 230236..230724 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" CDS 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" gene 230717..231508 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" downshifts 231483 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" CDS 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" gene 231563..231841 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" promotor_-35 231884..231893 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231902 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" promotor_-10 231906..231921 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" gene 231947..233287 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" downshifts 233287 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" upshifts 233353 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" misc_feature 233356..233375 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" gene 233395..234282 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" S_feature 234283..234426 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 234398..234405 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234419..234438 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234428 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" CDS 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" gene 234482..235450 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" promotor_-10 complement(235304..235322) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(235321) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(235338..235343) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235447 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" downshifts complement(235486) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" CDS complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" gene complement(235486..236730) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" promotor_-10 complement(236764..236782) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236773) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236793..236801) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236801..236819) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236817) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" promotor_-35 complement(236835..236840) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" gene complement(236875..238770) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" downshifts complement(236891) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" misc_feature 238636..238655 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238653 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" gene complement(238791..239540) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" S_feature 239513..239694 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239541..239611) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239600..239619) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239615) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" promotor_-35 complement(239635..239642) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239681..239688 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239696 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" promotor_-10 239701..239720 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" gene 239759..240466 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" promotor_-35 240432..240433 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240449..240463 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240459 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" CDS 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" gene 240500..240775 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" promotor_-10 complement(240558..240576) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240564) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(240591..240597) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240767 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" promotor_-35 240818..240822 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240838..240857 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240844 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" S_feature 240855..240983 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" gene 240984..242054 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" downshifts 242043 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" CDS complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" gene complement(242091..243503) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" downshifts complement(242108) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" S_feature complement(243504..243615) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243588..243607) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243615) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" promotor_-35 complement(243622..243629) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" gene complement(243624..244571) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" promotor_-10 complement(244609..244628) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244626) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" promotor_-35 complement(244643..244650) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" gene complement(244700..246136) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" downshifts complement(244715) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" CDS complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" gene complement(246159..247142) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" promotor_-10 complement(247236..247253) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 247241..247260 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(247243) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 247247 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(247269..247276) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" gene 247444..248676 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" CDS 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" gene 248687..249631 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" downshifts 249608 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" promotor_-35 249728..249735 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249740..249857 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249740 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" promotor_-10 249749..249768 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" gene 249858..250784 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" CDS 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" gene 250814..252280 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" CDS 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" gene 252364..253731 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" CDS 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" gene 253768..255135 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" promotor_-35 255149..255156 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 255171..255188 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 255174 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" CDS 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" gene 255205..255906 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" downshifts 255856 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" downshifts 255900 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" CDS 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" gene 255997..257529 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" promotor_-35 257541..257544 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257559..257578 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257571..257805 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257571 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" CDS 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" gene 257806..258726 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" promotor_-35 258728..258735 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258750..258769 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258760 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" misc_RNA 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" gene 258783..259030 /gene="tboW" /locus_tag="BSU_misc_RNA_6" downshifts 258999 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" CDS 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" gene 259128..259289 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" promotor_no_box 259206..259306 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 259266 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" gene 259310..260248 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" downshifts 259354 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" misc_feature 260271..260290 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 260276..260344 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 260276 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" CDS 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" gene 260345..261025 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" CDS 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" gene 261027..261962 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" CDS 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" gene 262054..262977 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" S_feature complement(262524..263708) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" gene 262996..263682 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" CDS complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" gene complement(263643..263777) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" downshifts 263677 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" CDS complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" gene complement(263737..264123) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" downshifts complement(263753) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(264149..264167) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264168) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" promotor_-35 complement(264181..264187) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(264201..265199) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(264244) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" promotor_-35 264380..264385 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 264399 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" promotor_-10 264401..264419 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264413) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" promotor_-10 complement(264415..264429) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264435) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" promotor_-35 complement(264437..264441) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" gene 264437..264865 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" downshifts 264844 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" promotor_-35 264910..264916 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264929..264948 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264931 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" CDS 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" gene 264971..265702 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" promotor_-10 complement(265173..265192) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265199) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" promotor_-35 complement(265206..265213) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265620 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" CDS 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" gene 265784..265960 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" promotor_-35 265912..265918 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265925..265942 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265936 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" CDS 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" gene 265979..267730 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" promotor_-10 complement(266033..266048) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(266039) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(266061..266070) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" gene 267743..267955 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" S_feature 267956..268015 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" gene 268016..268744 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" downshifts complement(268024) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" CDS complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" gene complement(268741..269388) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" promotor_-10 complement(269403..269422) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269416..269422 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269417) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" promotor_-10 269437..269456 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269437..269441) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 269439 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" CDS 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" gene 269467..270579 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" upshifts complement(269813) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(269816..269835) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269851..269855) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270573 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" CDS complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" gene complement(270621..272060) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" downshifts complement(270628) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" CDS complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" gene complement(272100..272666) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" promotor_-10 complement(272704..272723) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272718) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" promotor_-35 complement(272738..272745) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272820..272826 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272842..272859 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272848 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" CDS 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" gene 272883..274010 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" downshifts 273983 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" promotor_-35 274107..274113 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 274127..274146 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 274127 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" CDS 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" gene 274173..274811 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" downshifts 274797 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" S_feature 274842..275432 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" gene complement(274849..275232) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" downshifts complement(274873) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(275262..275281) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(275269) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" promotor_-35 complement(275295..275302) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275404..275407 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275423..275442 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275434 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" CDS 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" gene 275467..276543 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" downshifts 276537 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" CDS complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" gene complement(276583..277539) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" downshifts complement(276611) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" CDS complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" gene complement(277552..278253) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" promotor_-10 complement(278277..278296) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(278283) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" promotor_-35 complement(278312..278315) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 278333..278336 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278352..278371 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278362 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" CDS 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" gene 278397..279137 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" CDS 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" gene 279138..280298 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" promotor_-35 280349..280357 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 280369..280387 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 280369 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" CDS 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" gene 280434..281366 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" CDS complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" gene complement(281406..282470) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" downshifts complement(281407) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" S_feature complement(282471..282661) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " gene complement(282493..282624) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" promotor_-10 complement(282646..282665) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282666) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" promotor_-35 complement(282680..282687) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" gene 282798..284216 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" promotor_-10 complement(284259..284277) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(284267) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(284291..284298) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 284323..284402 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 284323 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" promotor_-35 284325..284331 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 284346..284363 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" gene 284403..285764 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" S_feature 285765..286345 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" gene complement(285772..286275) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" S_feature complement(286276..286357) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 286347 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" promotor_-10 complement(286349..286368) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 286350..286369 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(286358) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" promotor_-35 complement(286381) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" gene 286398..287519 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" downshifts 287513 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" promotor_-35 287560..287566 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287581..287599 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287584 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" gene 287626..288402 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" downshifts complement(287633) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" CDS 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" gene 288427..290112 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" promotor_no_box 289367..289467 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289427 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 289493 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" downshifts 290109 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" promotor_-35 290203..290210 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290226..290245 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290232 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" CDS 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" gene 290300..291259 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" promotor_-35 290855..290861 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290875..290894 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290879 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" downshifts 291231 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" CDS 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" gene 291315..292010 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" CDS 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" gene 291968..292810 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" downshifts 292797 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" CDS complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" gene complement(292848..293843) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" promotor_-35 293799..293806 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293821..293840 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293827..294029 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293827 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" promotor_-10 complement(293875..293894) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293883) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" promotor_-35 complement(293909..293916) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 294013..294022 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 294031..294126 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 294031 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" promotor_-10 294035..294050 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" gene 294127..294726 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" CDS 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" gene 294748..295329 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" CDS 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" gene 295364..295942 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" CDS 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" gene 295993..296766 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" downshifts 296753 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" CDS 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" gene 296851..298464 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" CDS 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" gene 298480..299571 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" downshifts 299545 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" promotor_-35 299625..299632 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299647..299666 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299655 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" CDS 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" gene 299693..300895 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" downshifts 300875 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" CDS complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" gene complement(301148..302320) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" downshifts complement(301163) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" CDS complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" gene complement(302389..302691) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" downshifts complement(302417) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(302674..302693) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302693) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" promotor_-35 complement(302707..302713) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302940..302959 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302940 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" CDS 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" gene 302981..304237 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" downshifts complement(302989) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" CDS 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" gene 304239..305087 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" CDS 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" gene 305087..305968 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" downshifts 305949 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" downshifts complement(305981) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" CDS complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" gene complement(306006..307157) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" downshifts complement(306025) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" S_feature complement(307158..307245) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 307213..307220 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(307232..307251) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 307235..307254 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(307245) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" upshifts 307248 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" promotor_-35 complement(307264..307270) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" gene 307307..308740 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" promotor_-35 308045..308053 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308065..308083 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308084 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 308722 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" promotor_-35 308783..308790 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308805..308824 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308814 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" CDS 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" gene 308856..309437 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" upshifts 309250 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" misc_feature 309254..309258 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309413..309420 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309435..309454 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309448..309585 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309448 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" CDS 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" gene 309586..311565 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" downshifts 311579 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" promotor_-35 311645..311652 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311662 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" promotor_-10 311666..311685 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" gene 311742..312707 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" CDS 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" gene 312739..314364 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" downshifts 312745 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" downshifts 314351 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" CDS complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" gene complement(314409..315947) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" downshifts complement(314427) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(315001..315101) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(315041) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 315961..315965 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315981..316000 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315995 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" promotor_-10 complement(316027..316046) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(316030) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" CDS 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" gene 316060..316524 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" promotor_-35 complement(316061..316067) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316534..316539 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316555..316573 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316565 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" CDS 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" gene 316598..317227 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" promotor_-35 317238..317247 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 317261..317280 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 317269 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" CDS 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" gene 317297..318058 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" S_feature complement(317697..318059) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 318055 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" CDS complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" gene complement(318060..319400) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" promotor_-10 complement(319427..319438) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319437) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" promotor_-35 complement(319453..319459) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319479..319485 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319493 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" promotor_-10 319500..319511 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" gene 319530..320126 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" promotor_-35 320134..320141 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 320155..320255 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 320155..320174 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 320155 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" downshifts complement(320251) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" CDS 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" gene 320256..321074 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" downshifts 321056 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" CDS complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" gene complement(321124..321717) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" downshifts complement(321131) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(321732..321751) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321747) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(321766..321769) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321775..321923) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321825..321832 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321845..321864 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321847..321955 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321849 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" promotor_-10 complement(321917..321935) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321923..321930 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321933) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" promotor_-10 321945..321964 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321951..321956) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321957 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" CDS 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" gene 321993..322553 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" downshifts 322530 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" CDS complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" gene complement(322581..323342) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" downshifts complement(322605) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(323374..323393) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 323375..323382 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(323380) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" promotor_-10 323397..323416 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323408..323413) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323409 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" CDS 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" gene 323460..324434 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" S_feature 324435..324505 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" gene 324506..325462 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" promotor_-35 324921..324927 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324942..324953 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324949 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" S_feature 325463..325541 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325516..325521 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325538..325556 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325543 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" CDS 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" gene 325546..326328 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" downshifts 326293 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" S_feature 326338..326465 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326442..326446 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326461..326480 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326467 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" gene 326519..327430 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" CDS 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" gene 327447..328994 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" promotor_-35 328418..328424 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328438..328457 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328446 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" promotor_-35 328529..328535 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328548..328567 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328557 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" misc_feature 328993..328997 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328995..329117 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328997 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" CDS 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" gene 329118..330539 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" S_feature complement(329638..331493) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330519 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" S_feature 330564..330660 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330631..330638 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330653..330672 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330662 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" CDS 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" gene 330692..331927 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" promotor_-10 complement(331486..331504) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331503) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" promotor_-35 complement(331518..331525) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331911) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" CDS complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" gene complement(331964..332821) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" downshifts complement(331977) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" CDS complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" gene complement(332826..333710) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" upshifts complement(333762) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" promotor_-10 complement(333767..333780) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333795..333803) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" gene complement(333810..334664) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" promotor_-10 complement(334683..334702) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334703) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" promotor_-35 complement(334717..334720) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334754..334773 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334754..334772) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334761..334825 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334762 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" upshifts complement(334771) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(334788..334793) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" gene 334826..335836 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" S_feature 335837..338284 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" gene complement(335868..337319) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" downshifts complement(335872) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" CDS complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" gene complement(337380..337700) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" promotor_-35 337551..337556 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337570..337574 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337577 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(337609) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" promotor_-10 complement(337611..337630) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337644..337651) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" gene complement(337732..340149) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" promotor_-10 complement(340174..340193) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(340188) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 complement(340205..340211) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" gene complement(340271..342403) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" CDS complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" gene complement(342410..344725) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" promotor_no_box complement(344744..344844) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344784) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" promotor_-35 344827..344834 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344848..344867 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344860 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" CDS 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" gene 344905..346110 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" downshifts 346095 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" promotor_-35 346154..346160 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 346175..346194 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 346183 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" CDS 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" gene 346227..347141 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" CDS 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" gene 347138..347722 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" promotor_-35 347733..347740 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347754..347773 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347764 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" CDS 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" gene 347818..348003 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" CDS 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" gene 348031..349224 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" downshifts 349216 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" S_feature 349261..350930 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" gene complement(349273..349953) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" downshifts complement(349279) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" CDS complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" gene complement(349963..350826) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" promotor_-10 complement(350848..350867) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350860) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" S_feature complement(350862..353696) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350882..350889) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350899..350905 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350920..350938 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350932..351154 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350932 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" CDS 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" gene 350988..351185 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" promotor_-35 351123..351128 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351144..351162 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351156 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" CDS 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" gene 351204..351659 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" downshifts 351634 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" promotor_-35 351682..351688 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351695 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" promotor_-10 351702..351713 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" gene 351741..352073 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" downshifts 352054 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" promotor_-35 352159..352166 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 352182..352201 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 352186 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" CDS 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" gene 352227..353660 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" downshifts 353638 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" CDS complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" gene complement(353697..354095) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" promotor_no_box complement(354092..354192) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" gene complement(354122..354571) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" upshifts complement(354132) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" promotor_-10 complement(354586..354605) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354594) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" S_feature complement(354596..354738) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354619..354626) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" gene complement(354739..356460) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" promotor_-35 354751..354758 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354769..357912 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354769 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" promotor_-10 354773..354792 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354774..354874) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354814) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" promotor_-10 complement(356484..356502) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356499) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" promotor_-35 complement(356516..356523) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" gene complement(356571..357128) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" downshifts complement(356574) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" CDS complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" gene complement(357134..357766) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" promotor_-10 complement(357792..357811) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357807) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" promotor_-35 complement(357826..357829) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357890..357893 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357908..357927 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357914 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" CDS 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" gene 358000..358362 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" downshifts 358346 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" promotor_-35 358609..358612 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358627..358646 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358635..358935 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358635 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" CDS 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" gene 358936..369699 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" CDS 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" gene 369712..380463 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" CDS 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" gene 372848..372988 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" CDS 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" gene 380500..384327 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" CDS 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" gene 384356..385084 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" downshifts 385066 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" promotor_-35 385122..385129 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 385132 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" promotor_-10 385141..385160 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" gene 385185..386411 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" downshifts 386405 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" CDS complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" gene complement(386426..386983) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" promotor_no_box complement(386441..386541) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386463) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" upshifts complement(386481) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(387012..387031) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(387014) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" CDS complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" gene complement(387037..387975) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" promotor_-10 complement(388014..388032) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388021) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(388048..388053) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" gene 388099..389433 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" CDS complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" gene complement(389428..389595) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo CDS complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" gene complement(389606..390103) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo misc_feature complement(390130..390149) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(390142) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" CDS complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" gene complement(390208..390855) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" promotor_-10 complement(390884..390903) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390887) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" promotor_-35 complement(390919..390923) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(391024..391175) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" gene complement(391176..391919) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" downshifts complement(391232) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" CDS complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" gene complement(391933..392637) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" CDS complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" gene complement(392624..393430) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" promotor_-10 complement(393479..393498) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393491) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(393512..393519) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" gene complement(393546..394418) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" promotor_-10 complement(394156..394174) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394163) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" promotor_-35 complement(394189..394195) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394472..394479 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394487..394506) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394493..394512 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394493) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" upshifts 394501 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" CDS 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" gene 394508..395122 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" promotor_-35 complement(394520..394527) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" gene 395125..396546 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" CDS 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" gene 396563..396790 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" CDS 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" gene 396787..397251 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" downshifts 397232 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" misc_feature 397258..397259 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 397259 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" gene 397318..398163 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" CDS complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" gene complement(398203..399681) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" downshifts complement(398211) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" promotor_-35 399708..399710 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399709..399728) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399719 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 399727..399745 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399729) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" S_feature complement(399731..400235) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399743..399750) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399899..399908 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399921..399940 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399922 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" CDS 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" gene 399961..401715 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" promotor_-10 complement(400232..400250) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(400245) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" promotor_-35 complement(400266..400271) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401706 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" CDS complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" gene complement(401731..401952) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" promotor_-10 complement(401971..401982) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401973) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" promotor_-35 complement(401997..402003) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 402018..402024 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402038..402049 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402051 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" CDS 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" gene 402078..403712 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" CDS 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" gene 403702..404925 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" CDS 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" gene 404950..406071 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" downshifts 406055 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" CDS complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" gene complement(406176..406856) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" CDS complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" gene complement(406872..408332) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" misc_feature 408502..408521 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408505 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" CDS 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" gene 408545..409228 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" CDS 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" gene 409215..410636 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" downshifts 410612 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" S_feature 410657..410761 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410751..410770 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410763 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" downshifts complement(410795) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" CDS 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" gene 410799..411947 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" promotor_-35 411647..411652 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411665 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" promotor_-10 411669..411687 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411809..411817 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411829..411847 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411841 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" CDS 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" gene 411931..412053 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" downshifts 412040 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" downshifts complement(412108) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" CDS complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" gene complement(412153..412242) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" downshifts complement(412313) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" CDS complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" gene complement(412324..412437) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" promotor_-10 complement(412458..412477) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412469) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" promotor_-35 complement(412490..412499) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" gene complement(412591..413955) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" downshifts complement(412599) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" downshifts complement(412643) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(413991..414010) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(414007) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" promotor_-35 complement(414025..414032) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 414146..414150 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414166..414185 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414178 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" promotor_-35 414209..414216 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414230..414249 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414239..414339 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 414239 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" CDS 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" gene 414340..415290 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" CDS 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" gene 415283..416230 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" CDS 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" gene 416224..416982 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" CDS 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" gene 417004..417957 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" downshifts 417940 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" CDS complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" gene complement(418004..419422) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" downshifts complement(418025) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" CDS complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" gene complement(419442..420320) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" S_feature complement(420321..420387) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(420386..420405) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(420395) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" promotor_-35 complement(420420..420426) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" gene complement(420484..421233) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" downshifts complement(420497) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" CDS complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" gene complement(421250..421537) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" promotor_-35 421503..421510 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421524..421543 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421543 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(421581..421600) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421597) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" promotor_-35 complement(421614..421621) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421642..421649 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421654 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" promotor_-10 421660..421679 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" gene 421677..421991 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" downshifts 421983 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" CDS complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" gene complement(421993..423432) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" promotor_-10 complement(422317..422328) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(422323) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(422342..422348) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423475..423494) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423476..423483 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423482) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 423497..423516 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423501 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" promotor_-35 complement(423505..423512) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" gene 423539..424849 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" promotor_-35 424727..424733 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424747..424765 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424755 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" promotor_-35 424851..424858 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424873..424892 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424882 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" CDS 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" gene 424918..426306 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" downshifts 426314 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" promotor_-35 426364..426370 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426384..426395 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 426385 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" CDS 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" gene 426429..427292 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" CDS 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" gene 427312..428097 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" misc_feature 427417..427436 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427417 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 427505 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" downshifts 428099 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" CDS complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" gene complement(428142..428756) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" downshifts complement(428153) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" CDS complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" gene complement(428769..430394) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" CDS complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" gene complement(430429..431001) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" promotor_-10 complement(431023..431042) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431038) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" promotor_-35 complement(431056..431063) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 431123..431142 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 431135 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" CDS 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" gene 431166..431519 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" downshifts 431490 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" promotor_-35 431583..431590 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431604..431623 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431609 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" S_feature 431619..431691 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" gene 431692..433128 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" CDS 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" gene 433153..433584 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" CDS 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" gene 433586..434707 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" downshifts 434690 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" promotor_-35 434736..434739 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434755..434774 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434757 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" CDS 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" gene 434798..435862 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" promotor_-35 435032..435040 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435054..435073 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435064 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 435856 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" promotor_-35 435929..435936 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435949..435968 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435962 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" CDS 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" gene 435997..436560 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" S_feature 436561..437285 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" gene complement(436620..437228) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" misc_feature complement(437246..437265) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 437262..437268 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(437269) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" promotor_-10 437281..437300 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437287 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" CDS 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" gene 437314..437706 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" downshifts 437683 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" CDS complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" gene complement(437739..437903) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" downshifts complement(437759) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(437913..437931) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437935) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" promotor_-35 complement(437946..437952) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437965..437972 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437986..438005 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437989 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" CDS 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" gene 438036..438785 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" downshifts 438762 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" downshifts complement(438838) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" promotor_-35 438868..438874 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438888..438907 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438894..438990 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438894 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" CDS 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" gene 438991..439764 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" CDS 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" gene 439779..440993 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" CDS 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" gene 441017..441790 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" CDS 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" gene 441835..442557 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" CDS 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" gene 442560..443567 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" downshifts 443053 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" promotor_no_box 443147..443247 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 443207 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" CDS 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" gene 443583..444335 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" promotor_-35 444333..444342 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444356..444375 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444366 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" CDS 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" gene 444399..445040 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" downshifts 445026 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" S_feature complement(445038..445463) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(445083) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" promotor_-35 445116..445122 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445136..445155 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445137 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" CDS 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" gene 445213..445458 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" S_feature 445459..445869 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" gene complement(445464..445751) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" misc_feature complement(445772..445791) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445788) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" promotor_-35 445845..445849 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445866..445885 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445871 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" CDS 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" gene 445902..447908 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" S_feature 447909..448009 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" gene 448010..448912 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" downshifts 448892 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" promotor_-35 448985..448992 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 449006..449025 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 449010..449097 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 449010 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" CDS 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" gene 449098..451182 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" downshifts 451169 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" promotor_-35 451211..451217 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451231..451249 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451243 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" S_feature 451254..451335 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 451297..451304 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 451318..451337 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 451337 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" CDS 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" gene 451394..452905 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" downshifts 452889 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" CDS complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" gene complement(452925..453470) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" downshifts complement(452958) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(453537..453555) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453551) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" promotor_-35 complement(453570..453576) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453612..453618 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453630 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" promotor_-10 453633..453651 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" gene 453677..454537 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" CDS 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" gene 454553..455056 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" downshifts 455037 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" promotor_-35 455085..455092 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455106..455125 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455108 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" CDS 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" gene 455142..455693 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" promotor_-35 455708..455714 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455729..455747 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455742 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" CDS 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" gene 455771..456193 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" promotor_-35 456198..456206 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456217..456236 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 456236..456602 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 456236 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" promotor_no_box complement(456262..456362) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" gene complement(456297..456565) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" upshifts complement(456302) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 456559 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" promotor_-35 456639..456648 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456661..456676 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456666 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" CDS 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" gene 456699..457508 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" downshifts 457489 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" CDS complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" gene complement(457552..457842) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" downshifts complement(457556) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" misc_feature complement(457870..457889) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457870..457888 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457876 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(457886) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" promotor_-35 457964..457971 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457985..458004 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457989 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" CDS 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" gene 458027..458461 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" promotor_-35 458458..458461 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458470 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" promotor_-10 458478..458497 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" gene 458526..460709 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" downshifts 460692 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" promotor_-35 460758..460764 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460779..460797 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460780..460911 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460780 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" CDS 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" gene 460912..462000 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" CDS 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" gene 461981..462832 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" CDS 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" gene 462843..464552 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" CDS 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" gene 464545..465807 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" CDS 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" gene 465813..467924 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" downshifts 467908 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" promotor_-35 468021..468028 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468043..468062 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468050 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" misc_RNA 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" gene 468060..468203 /gene="swaO" /locus_tag="BSU_misc_RNA_7" downshifts 468201 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" S_feature 468246..468399 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" gene 468400..470223 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" downshifts 470215 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" CDS 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" gene 470282..470731 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" promotor_-35 470744..470750 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470765..470783 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470766 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" CDS 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" gene 470798..472522 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" S_feature complement(471634..472493) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472495..472606) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472506 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" CDS complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" gene complement(472514..472717) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" downshifts complement(472538) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" promotor_no_box complement(472566..472666) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472575..472580 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472597..472615 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472606) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" S_feature 472607..472822 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472607 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" S_feature complement(472673..472744) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472716) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" CDS complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" gene complement(472745..473011) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" promotor_-10 complement(473027..473046) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(473045) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" promotor_-35 complement(473058..473065) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" gene complement(473115..474392) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" downshifts complement(473134) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(474454..474473) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474466) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" S_feature complement(474468..474545) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474486..474493) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474529..474548) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474545) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" promotor_-35 complement(474562..474571) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" gene complement(474622..474879) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" downshifts complement(474630) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" downshifts complement(474696) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" CDS complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" gene complement(474957..475409) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" promotor_-10 complement(475428..475446) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475445) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" promotor_-35 complement(475460..475466) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475478 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" misc_feature 475486..475505 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" gene 475527..476345 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" downshifts 476336 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" promotor_-35 476413..476419 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476433..476451 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476441 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" CDS 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" gene 476474..476845 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" downshifts complement(476478) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" downshifts 476862 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" upshifts complement(476896) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(476899..476902) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476924..476931 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476943..476962 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476950 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" CDS 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" gene 476977..477318 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" CDS 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" gene 477312..477671 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" S_feature complement(477374..477667) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477612 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" downshifts 477656 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" CDS complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" gene complement(477708..478529) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" downshifts complement(477712) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" promotor_-10 complement(478551..478569) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478572) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" promotor_-35 complement(478583..478589) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" gene complement(478614..479666) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" promotor_-35 478926..478933 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478948..479735 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478948..478967 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478949 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" promotor_-10 complement(479679..479698) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479684) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" promotor_-35 complement(479712..479719) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" gene 479736..481343 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" CDS 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" gene 481333..482013 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" S_feature 482014..482088 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 482055..482062 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482077..482094 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 482090 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" CDS 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" gene 482134..483399 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" downshifts 483392 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" downshifts complement(483446) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" misc_feature 483483..483500 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483485 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" gene 483547..484599 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" S_feature 484600..484843 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484800 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" CDS 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" gene 484876..485802 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" CDS 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" gene 485822..486562 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" misc_feature 486621..486640 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486626 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" CDS 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" gene 486657..486992 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" downshifts 486967 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" S_feature 487012..487081 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 487047..487054 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 487068..487087 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 487082 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" CDS 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" gene 487120..488265 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" downshifts 488247 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" CDS complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" gene complement(488290..488469) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" downshifts complement(488308) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" CDS complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" gene complement(488423..488587) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" S_feature complement(488470..488638) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488630..488649) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488640) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" promotor_-35 complement(488664..488671) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488779..488784 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488800..488818 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488804 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" CDS 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" gene 488834..489706 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" promotor_-35 489070..489079 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489092..489107 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 489095 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" S_feature complement(489651..489720) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489694) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" S_feature 489707..490056 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" gene complement(489721..490041) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" promotor_-35 490037..490041 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490050..490064 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 490058..490215 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 490058 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" promotor_-10 complement(490062..490081) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(490077) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" promotor_-35 complement(490095..490102) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" gene 490216..491280 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" downshifts 491268 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" CDS 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" gene 491352..492725 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" promotor_-35 492756..492762 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492776..492787 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492786 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" misc_feature 492829..492848 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492830..493004 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492830 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" promotor_-35 492972..492979 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492994..493013 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 493006..493073 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 493006 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" CDS 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" gene 493125..494609 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" downshifts 494602 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" S_feature 494722..494781 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494722..494731 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494724 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" promotor_-10 494743..494758 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " gene 494782..495261 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" CDS 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" gene 495251..496732 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" downshifts 496702 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" S_feature 496747..497074 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496756) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" CDS complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" gene complement(496984..497583) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" promotor_-35 497044..497049 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 497062..497081 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 497076..497677 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 497076 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" misc_feature complement(497607..497626) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497618) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" CDS 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" gene 497678..498043 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" promotor_-35 498046..498051 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 498067..498208 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 498067..498085 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 498067 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" CDS 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" gene 498209..499225 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" downshifts 499210 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" promotor_-35 499270..499277 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 499291..499310 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 499298 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" gene 499340..500509 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" promotor_-35 500438..500443 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500458..500476 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500464 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" promotor_-35 500539..500542 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500558..500577 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500559 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" gene 500625..500906 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" CDS 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" gene 500911..501261 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" S_feature complement(501051..501527) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(501094) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" downshifts 501241 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" promotor_-35 501295..501302 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 501316..501335 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 501324 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" gene 501376..502200 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" promotor_-10 complement(501510..501528) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501527) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" S_feature complement(501529..502128) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501542..501549) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(502117..502135) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502128) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" S_feature complement(502130..502718) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(502149..502155) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" gene 502205..502570 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" CDS 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" gene 502574..502975 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" promotor_-10 complement(502716..502735) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502733) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" promotor_-35 complement(502749..502758) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" gene 502987..503994 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" promotor_-35 503988..503994 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504009..504027 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504015 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" CDS 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" gene 504056..504385 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" CDS 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" gene 504382..504864 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" CDS 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" gene 504830..505618 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" CDS 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" gene 505618..506217 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" downshifts 506203 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" promotor_-35 506261..506267 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506282..506301 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506294 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" gene 506328..506444 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" CDS 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" gene 506460..506753 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" promotor_-35 506721..506729 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506741..506760 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" gene 506750..507190 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" upshifts 506756 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" S_feature complement(506989..510044) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" gene 507174..507617 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" downshifts 507592 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" promotor_-35 507648..507649 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507665..507684 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507665 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" CDS 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" gene 507711..509870 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" misc_feature 509858..509877 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509880..510096 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509880 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" CDS complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" gene complement(509880..509993) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" promotor_-10 complement(510033..510052) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(510050) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" promotor_-35 complement(510067..510075) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" gene 510097..510549 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" promotor_-35 510555..510561 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510576..510595 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510584..510671 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510584 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" downshifts complement(510616) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" tRNA 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510672..510746 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" tRNA 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510751..510841 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" tRNA 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510871..510942 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" tRNA 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 510954..511028 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" tRNA 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511055..511130 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" tRNA 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511142..511223 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" downshifts 511288 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" tRNA 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 511304..511390 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" downshifts 511377 /Source="Nicolas_upshifts" /id="D229" /incds=0 /nref=82 /ntot=235 /MaxReadThrough="4.38481" /MaxDrop="5.23398" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=89 /isTUend="FALSE" S_feature 511422..512320 /Source="Nicolas_S_feature" /locus_tag="new_529454_530352" /HighExp="Cold, G180, G135, Paraq, Oxctl, C30, G150, H2O2, Fru, Lbexp" /AntisenseName="ydcL" /AntisenseCor="-0.23338643759911901" /AntisenseRegPval="-4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S169" downshifts complement(511445) /Source="Nicolas_upshifts" /id="D230" /incds=0 /nref=96 /ntot=231 /MaxReadThrough="2.93365" /MaxDrop="6.05127" /score="8.78044068" /energy="-9.2" /TU="U381" /idTUdmin="U381" /TUdmin="-125" /isTUend="FALSE" CDS complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22505685; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: integrase" /protein_id="NP_388361.1" /db_xref="EnsemblGenomes-Gn:BSU04800" /db_xref="EnsemblGenomes-Tr:CAB12287" /db_xref="GOA:P96629" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG12099" /db_xref="UniProtKB/Swiss-Prot:P96629" /translation="MSVKKLENGQYQVDVSFGFDPITGERIRTRPVASTRKEALELEA KLRREFQEERARKSRSVSFPTLISIYLASCEIDSKPNYYQNQKYIINKHISDYFLKSD IQKITHREITDFRKHLMETGLSNKSVNNIMTSLSKIFDTAVHEEILKRNPCDNVKRLP LTRKKMKFWRPEEFKKFISLIPQDQLLFKTFYTVAFLTGLRCGEMLALQWKDIDKILL EIDVHKSCTWLDGQFVVTTPKTKNSIRRVSINKKLLKLLERWKEAQEELFNELGIRHS HDTYIFQYKDTPSRKDIFSRKIKYFCKDSDLTPIRLHDFRHSHVALLIHQGEDYITIK ERLGHGSVKTTIDVYGHLYPNKQKEMADKLDDLL*" gene complement(511473..512579) /gene="ydcL" /locus_tag="BSU_04800" /old_locus_tag="BSU04800" CDS complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:18761623, 21036995, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18761623, 21036995, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: site-specific protease cleaving ImmR" /protein_id="NP_388362.1" /db_xref="EnsemblGenomes-Gn:BSU04810" /db_xref="EnsemblGenomes-Tr:CAB12288" /db_xref="GOA:P96630" /db_xref="InterPro:IPR010359" /db_xref="SubtiList:BG12100" /db_xref="UniProtKB/Swiss-Prot:P96630" /translation="MITIYTSKGIKHKVQSVIKTHGTNNVYEICDIQKIYILKNDLGQ ANGLLQHDKATDQYLIHINENLQHQQFVIAHELGHYFLHKRLNTFKVVNCSKVLKDKL EHQASLFASELILTDKMLNEALPYIQGFSKEQIAAYFNVPSFVTDYKLSQIGSFSNRI YSHEISAFG*" gene complement(512592..513101) /gene="immA" /locus_tag="BSU_04810" /old_locus_tag="BSU04810" downshifts complement(512904) /Source="Nicolas_upshifts" /id="D231" /incds=1 /nref=12 /ntot=39 /MaxReadThrough="6.14325" /MaxDrop="3.22989" /score="17.0287275" /energy="-11.8" /TU="U381" /idTUdmin="U384" /TUdmin=1518 /isTUend="FALSE" CDS complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8083175, 17511812, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8083175, 17511812, 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: transcriptional regulator(Xre family)" /protein_id="NP_388363.1" /db_xref="EnsemblGenomes-Gn:BSU04820" /db_xref="EnsemblGenomes-Tr:CAB12289" /db_xref="GOA:P96631" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG12101" /db_xref="UniProtKB/Swiss-Prot:P96631" /translation="MSLGKRLKEARQKAGYTQKEAAEKLNIGNNNLSNYERDYRDPDT DTLLKLSNLYNVSTDYLLGKDEVSKKNETDLLNKTINEAIQELKDEDTLLFMNDGEFD EETARLVKKALKNGIKFIDELKKKE*" gene complement(513098..513481) /gene="immR" /locus_tag="BSU_04820" /old_locus_tag="BSU04820" promotor_-10 complement(513510..513529) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513522) /Source="Nicolas_upshifts" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" promotor_-35 complement(513544..513551) /Source="Nicolas_upshift_promotors" /id="U381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=3028 /SigmaFactorBS="tagaattatttatttaacttataggtgaaatTAATGAATtct ccaaaaaatgtTGTTATTATTTTTATAAAAAtcaactctttgtgaaatggatgataaa a" /listShort="immR, immA, ydcL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 513681..513688 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-35" promotor_-10 513703..513722 /Source="Nicolas_upshift_promotors" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /label="promotor_-10" upshifts 513708 /Source="Nicolas_upshifts" /id="U382" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2860 /SigmaFactorBS="tgttcaaaaaaatacactttaaggtgaattttgTGTTGACTt acacgaaaaggagTTTTATAATAAAGTTAATTCacaaagagttgagttaacgaggagg t" /listShort="sacV, ydzL, ydcO, S171, ydcP, ydcQ, ydcR" /listLong="S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" CDS 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3269394, 17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3269394, 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: excisionase" /protein_id="NP_388364.1" /db_xref="EnsemblGenomes-Gn:BSU04830" /db_xref="EnsemblGenomes-Tr:CAB12290" /db_xref="GOA:O31490" /db_xref="SubtiList:BG12670" /db_xref="UniProtKB/Swiss-Prot:O31490" /translation="MKGEFLTARDIQKILGVKQAKSYDIIRTLNAQMKEEGYMVIQGK VSRAKFEECYCYKGPKSQTG*" gene 513755..513949 /gene="xis" /locus_tag="BSU_04830" /old_locus_tag="BSU04830" CDS 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="YP_003097681.1" /db_xref="EnsemblGenomes-Gn:BSU04839" /db_xref="EnsemblGenomes-Tr:CAX52552" /db_xref="UniProtKB/Swiss-Prot:C0H3V5" /translation="MIFINIDITNSFMKEAVPLARQMEGDWIARMKIALNSVIINHYL NLPLTIENVNELLRKGVSYRRICKHYGIGRKDIEKLRQSSVV*" gene 513946..514206 /gene="ydzL" /locus_tag="BSU_04839" /old_locus_tag="BSU04839" CDS 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685, 26013486; Product type h:extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388365.1" /db_xref="EnsemblGenomes-Gn:BSU04840" /db_xref="EnsemblGenomes-Tr:CAB12291" /db_xref="SubtiList:BG12102" /db_xref="UniProtKB/Swiss-Prot:P96632" /translation="MKIRVNATIITDVEALKADKDLNHFKDYATCETFVVDADNHLKA NEEISELLKGWDWWCIWSTRPLSKKDNQVFTLYNDDLYNLCR*" gene 514260..514520 /gene="ydcO" /locus_tag="BSU_04840" /old_locus_tag="BSU04840" S_feature complement(514380..514620) /Source="Nicolas_S_feature" /locus_tag="new_532412_532652_c" /HighExp="T5.0H, T4.0H, T3.0H, Lbstat, T3.30H, T2.0H, Cold, Gly, S2, T2.30H" /AntisenseName="ydcO" /AntisenseCor="0.131178357364787" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S170" promotor_-35 514546..514553 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" /product="ICEBs1 mobile element: conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796, 22505685; Product type n: RNA" gene complement(514551..514610) /gene="sncO" /locus_tag="BSU_misc_RNA_65" promotor_-10 514568..514587 /Source="Nicolas_upshift_promotors" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 514572..514889 /Source="Nicolas_S_feature" /locus_tag="new_532604_532921" /HighExp="T0.30H, T0.0H, T1.0H, T1.30H, T-0.40H, T2.0H, HiOs, T2.30H, MG 120, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S171" upshifts 514572 /Source="Nicolas_upshifts" /id="U383" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.99000999000999" /xcortree=2861 /SigmaFactorBS="tgtcgataggagtgtttgttccttgaaaactacaTATAGACA aaaaaagcgccttgACGAATGATCATCAAGAACGccggaaaataaaaactagacactt t" /listShort="S171, ydcP, ydcQ, ydcR, S172, ydcS, ydcT, yddA, yddB, yddC, yddD, yddE, yddF, yddG, yddH, yddI, yddJ" /GFF_Attribute="listLong" promotor_-10 complement(514605..514624) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(514620) /Source="Nicolas_upshifts" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" promotor_-35 complement(514638..514645) /Source="Nicolas_upshift_promotors" /id="U384" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78021978021978" /psig="0.987012987012987" /xcortree=3113 /SigmaFactorBS="tttaaagtgattgctgttcatcactcaaatactcaCGCATGA CatttcaacaagaaTACCGTATAATAAAAGTGTCtagtttttattttccggcgttctt g" /listShort="S170" /GFF_Attribute="listLong" /label="promotor_-35" CDS 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 22505685" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: hypothetical protein" /protein_id="YP_009513947.1" /translation="MMAIISLLGCHEGVKPLATDKRQDGYRTGANQKHKIEINVLL*" gene 514726..514854 /locus_tag="BSU_04849" /old_locus_tag="BSU04849" CDS 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" /experiment="publication(s) with functional evidences, PMID:22505685, 23326247, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 23326247, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: helicase processivity factor" /protein_id="NP_388366.1" /db_xref="EnsemblGenomes-Gn:BSU04850" /db_xref="EnsemblGenomes-Tr:CAB12292" /db_xref="InterPro:IPR010365" /db_xref="SubtiList:BG12103" /db_xref="UniProtKB/Swiss-Prot:P96633" /translation="MNLNFIVPDINMTFGDMKFMGLNRERYVYDRENNKRTDVLESRI YNIASAVQGGQIEVTIPEYAGAKEIPPFADIELKNPKISAMATSQRDSTYANVMWKLE ADDIVVKGGSSVKPAAATGGNEKK*" gene 514890..515270 /gene="helP" /locus_tag="BSU_04850" /old_locus_tag="BSU04850" CDS 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" /experiment="publication(s) with functional evidences, PMID:17511812, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: coupling conjugation protein VirD4" /protein_id="NP_388367.1" /db_xref="EnsemblGenomes-Gn:BSU04860" /db_xref="EnsemblGenomes-Tr:CAB12293" /db_xref="GOA:P96634" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12104" /db_xref="UniProtKB/Swiss-Prot:P96634" /translation="MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLF WREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQK IAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRF QNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMK HISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLP KKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAF MDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGL MSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALV GVEGAQATAVASGSVSDQTASGEGVSEANG*" gene 515306..516748 /gene="conQ" /locus_tag="BSU_04860" /old_locus_tag="BSU04860" CDS 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" /experiment="publication(s) with functional evidences, PMID:17511812, 17693500, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17511812, 17693500, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: DNA relaxase" /protein_id="NP_388368.1" /db_xref="EnsemblGenomes-Gn:BSU04870" /db_xref="EnsemblGenomes-Tr:CAB12294" /db_xref="GOA:P96635" /db_xref="InterPro:IPR003491" /db_xref="SubtiList:BG12105" /db_xref="UniProtKB/Swiss-Prot:P96635" /translation="MDELKQPPHANRGVVIVKEKNEAVESPLVSMVDYIRVSFKTHDV DRIIEEVLHLSKDFMTEKQSGFYGYVGTYELDYIKVFYSAPDDNRGVLIEMSGQGCRQ FESFLECRKKTWYDFFQDCMQQGGSFTRFDLAIDDKKTYFSIPELLKKAQKGECISRF RKSDFNGSFDLSDGITGGTTIYFGSKKSEAYLCFYEKNYEQAEKYNIPLEELGDWNRY ELRLKNERAQVAIDALLKTKDLTLIAMQIINNYVRFVDADENITREHWKTSLFWSDFI GDVGRLPLYVKPQKDFYQKSRNWLRNSCAPTMKMVLEADEHLGKTDLSDMIAEAELAD KHKKMLDVYMADVADMVV*" gene 516741..517799 /gene="nicK" /locus_tag="BSU_04870" /old_locus_tag="BSU04870" downshifts 516744 /Source="Nicolas_upshifts" /id="D232" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="5.48512" /MaxDrop="3.25403" /score="-9.5933493" /energy="-23.1" /TU="U382,U383" /idTUdmin="U382" /TUdmin="-176" /isTUend="FALSE" S_feature 517800..518063 /Source="Nicolas_S_feature" /locus_tag="new_535832_536095" /HighExp="T0.30H, T1.0H, T1.30H, T0.0H, T2.0H, T2.30H, T-0.40H, T3.0H, T3.30H, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigA" /TUlongPSig=1 /label="S172" CDS 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388369.1" /db_xref="EnsemblGenomes-Gn:BSU04880" /db_xref="EnsemblGenomes-Tr:CAB12295" /db_xref="SubtiList:BG12106" /db_xref="UniProtKB/Swiss-Prot:P96636" /translation="MHNVNLLNQAGLENALESVGCLDIVEDLIEKMQEYVLYHTETAE RFAIDIFTVVNNYTKKVHAIFNVLENEDGETNVKNVEFEVMHFTE*" gene 518064..518333 /gene="ydcS" /locus_tag="BSU_04880" /old_locus_tag="BSU04880" promotor_-10 complement(518124..518143) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(518140) /Source="Nicolas_upshifts" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(518158..518165) /Source="Nicolas_upshift_promotors" /id="U385" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.956043956043956" /psig="0.998001998001998" /xcortree=2065 /SigmaFactorBS="aatctttcggcagtttcggtatgatacaaaacataTTCCTGC AtcttttctattaaaTCTTCTACAATATCTAAACAgccaactgattccaaagcatttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388370.1" /db_xref="EnsemblGenomes-Gn:BSU04890" /db_xref="EnsemblGenomes-Tr:CAB12296" /db_xref="SubtiList:BG12107" /db_xref="UniProtKB/Swiss-Prot:P96637" /translation="MFNINLLNQARLESDLDSLGCLDIAEELIEKMMEDVFYSDVAQR IIVQTLAVINNANAKLQATFNILEDEDMETDERSVEFEGISYYE*" gene 518372..518638 /gene="ydcT" /locus_tag="BSU_04890" /old_locus_tag="BSU04890" CDS 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388371.1" /db_xref="EnsemblGenomes-Gn:BSU04900" /db_xref="EnsemblGenomes-Tr:CAB12297" /db_xref="SubtiList:BG12108" /db_xref="UniProtKB/Swiss-Prot:P96638" /translation="MSAVDKRFKSLGFNVGIPSLVFVRSLSRDCMLVVEGERVKGFAE YRYTFYKTRYLPDGRMTSLKVYMENQSIKRVLHRVASFLSFLERTKQIEQKECEKVAQ *" gene 518655..518963 /gene="yddA" /locus_tag="BSU_04900" /old_locus_tag="BSU04900" CDS 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery VirB8" /protein_id="NP_388372.1" /db_xref="EnsemblGenomes-Gn:BSU04910" /db_xref="EnsemblGenomes-Tr:CAB12298" /db_xref="GOA:O31491" /db_xref="InterPro:IPR024735" /db_xref="InterPro:IPR035628" /db_xref="SubtiList:BG12109" /db_xref="UniProtKB/Swiss-Prot:O31491" /translation="MLNKEIGSDKKEESFFRSAFQKLKRIERPEKDKQKVPRDRSKLI AVTLWSCVGSLLFICLLAVLLSINTRSQLNDMKDETNKPTNDDKQKISVTAAENFLSG FINEYMNVKNDQESIEKRMQSLESYMVKQEDNHFEDEERFNVDGLKGDRELKGYSLYN VKEGDKNSLFQYKVTYENLYPVEKEVEKEVKDGKKKKKVKEKVKTNEKYEKQMLLNIP VTNKGDSFAVSAVPYFTQIYDLKGDIAFKGKEETRDEYAGEKKESIESFLQNFFEKYA SEKKEEMVYMMKKPEALEGNLLFGEVQSVKIFETKKGFEVFCAVRFKEKENDIPVNEK FSLEITENSGQFYVNKLKHQ*" gene 518953..520017 /gene="conB" /locus_tag="BSU_04910" /old_locus_tag="BSU04910" misc_feature 519491..519498 /Source="Nicolas_upshift_promotors" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 519494 /Source="Nicolas_upshifts" /id="U386" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.454545454545455" /xcortree=1489 /SigmaFactorBS="tgaaagaaggtgataaaaacagcctttttcaatataaggtca catatgaaaatctatACCCTGTAgaaaaggaagttgaaaaagaagttaaagacggaaa g" /listShort="yddC, yddD, yddE, yddF, yddG, yddH, yddI" /listLong="yddJ" downshifts 519582 /Source="Nicolas_upshifts" /id="D233" /incds=1 /nref=1 /ntot=15 /MaxReadThrough="6.32422" /MaxDrop="3.45679" /score="-2.67923628" /energy="-7.8" /TU="U383,U386" /idTUdmin="U382" /TUdmin=2662 /isTUend="FALSE" CDS 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388373.1" /db_xref="EnsemblGenomes-Gn:BSU04920" /db_xref="EnsemblGenomes-Tr:CAB12299" /db_xref="GOA:P96640" /db_xref="SubtiList:BG12110" /db_xref="UniProtKB/Swiss-Prot:P96640" /translation="MDFMNFFILGADLPTLGGVKGWASDVVIQFITIVVMFIAAKNLM KLKMGGIIFVCCIGSAVTWVIKHWSEFSGWINALMEKL*" gene 520029..520277 /gene="conC" /locus_tag="BSU_04920" /old_locus_tag="BSU04920" CDS 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" /experiment="publication(s) with functional evidences, PMID:22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: subunit of the conjugation machinery" /protein_id="NP_388374.1" /db_xref="EnsemblGenomes-Gn:BSU04930" /db_xref="EnsemblGenomes-Tr:CAB12300" /db_xref="GOA:P96641" /db_xref="InterPro:IPR025608" /db_xref="SubtiList:BG12111" /db_xref="UniProtKB/Swiss-Prot:P96641" /translation="MGRLVFNYRKAMREPKKIQQLTENYSLPFAVELIPAINYFIFVG LCFGFWYGVRMIFPHAFDNSYVIVIFGIPFFLTMLVTKIKPEGKNIYIYFFDFAKYYF FIKLPQKKYCNDRKIDLSNEKQIEFRKLVKVVDYSNETKNAYEGNTQEFAVNKNGRRV GVLPNKKQFDSYAK*" gene 520290..520814 /gene="conD" /locus_tag="BSU_04930" /old_locus_tag="BSU04930" CDS 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" /experiment="publication(s) with functional evidences, PMID:19734305, 19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19734305, 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB4-like ATPase" /protein_id="NP_388375.3" /db_xref="EnsemblGenomes-Gn:BSU04940" /db_xref="EnsemblGenomes-Tr:CAB12301" /db_xref="GOA:P96642" /db_xref="InterPro:IPR016628" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12112" /db_xref="UniProtKB/Swiss-Prot:P96642" /translation="MRLKTPMKAIHKNLLLTRTGDVWAYYRIKSNSIPMQNKEKVESY KKKWQHLFEEITSYEDFHLMMYPSEYELEKRFKDLETDIAADAMDVARYYNEETVRLL EQRLGRLTKYDFILGVKLKSSLVNISVELKDNILSFFNTATDTVVKMLGWEQNVSTSF FEKYEEVEETLANIMASVRGERLSETEMTYINRYHFVRGLKHQTNEESEIKDVRSITN TIIDPTDPSVLHLHSDQDEGYSAFVVIDEFLHNMSESDLFYEAQSLPFPVEVQMKIQT ESKSITKPALNLKRQQLKEEQKEQQSTGDRSDVSTVTSATMIRHLQDEIKKEDVHVMN WLSVIVVHGKTKKECVGKATIVKRHLKGAGITCRLPVADQLNLFYKMLPGEKLDITDK NWIQKTTQDGVAESLFAVNSDIGSKIGFFLGWVDRFQEHTDLESAIMSSRDFVLFHPF LANQQLKGSKTRSPHCLITGDTGNGKSYLAKLIFNYISMLNIKSLYIDPKKEMRKWIQ RVLNDEYIRENFPLYIAHLEKYNYITLDHENTHNWGALDPISFLPPMKAKELVQVIFE QVYDFKGKDDINTAFLRATSEVIDAKQKGEQVGSLDIIRKMQSHPEEAVQKAGDYLNE VVSDSILKLCIHDGSNPALSLEKRITILEVENMDLPDHAERLENYTISQLKSSAVMFA LGKFCELFGMNQDEQTVEFIDEAWIFTTSQQGKKVERQMRRIGRSYNNAEYFISQSTK DALKEEDSGNFGVAFAFDEPNEREEVLKWMNMEVTKDNKKMMESMFQGQCLFKDYYGR TSKISIECLFEEWQGALKTVEKKAVAYAEEKYL*" gene 520702..523197 /gene="conE" /locus_tag="BSU_04940" /old_locus_tag="BSU04940" CDS 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19943900, 22505685, 26013486; Producttype h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388376.1" /db_xref="EnsemblGenomes-Gn:BSU04950" /db_xref="EnsemblGenomes-Tr:CAB12302" /db_xref="InterPro:IPR015055" /db_xref="SubtiList:BG12113" /db_xref="UniProtKB/Swiss-Prot:P96643" /translation="MEIAFLNSLVVTSPGFYKAEKITLDEVKQWLKHYDGRYKSFIGH KSTAQFLQKLLGIRIEQNRKTFRHMKYQKAICFSLYERYPENVLLTQRDLEKARYQFY LLTRLD*" gene 523216..523542 /gene="yddF" /locus_tag="BSU_04950" /old_locus_tag="BSU04950" CDS 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" /experiment="publication(s) with functional evidences, PMID:19943900, 22505685, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19943900, 22505685, 26013486; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: VirB6 subunit of the conjugation machinery" /protein_id="NP_388377.1" /db_xref="EnsemblGenomes-Gn:BSU04960" /db_xref="EnsemblGenomes-Tr:CAB12303" /db_xref="GOA:P96644" /db_xref="InterPro:IPR000515" /db_xref="SubtiList:BG12114" /db_xref="UniProtKB/Swiss-Prot:P96644" /translation="MVVMKKKRILIVSAIVLLFLTVASAVTVFSADGDTTTQPKVEKA GGVELKVKRFPISRYQANNEASDDLIKGAFVGLTNVTFSFAGNIVRVVDTGMDILYNL QPIDEFANSITNVSKTVYKTLKKNFGEALFIFTCAYVVYLFCVRGSVKEAMRRSILFI CVMVIGGLWMSNAGYYMKVLNALSVEAQGKLLTAGNGLVGIVQDEGNFADSSAIEKGK EMEGTVAVMRNLYFDIALMKPFLIVNFDETSEKKINEEDTDKGGLNRIDKLLSYKLSE DGEKDKKDYIKETEIDDYKNESMTSGNVFNQLGESFIAVVASIVIGIPFLALAFFNFL LQVVALVIVFFVPFAFILAYVPQLAYSGFVTLGRLGSVYLLKAMLGVIVLFVYVTCFI VDKLIPPNGFGMYLLNVAVLASILWIGFHKRDAIIKFVTAGKVVSVDNNMMENMRQNI VQPAWEQAKKIGGVWGNGGGVFTDFTKHFGGRKDGSNADGVTGAPSGGGNSPSGTAMG YDNTHAISRTPQKETANGIANHNSRSLKRNPQTLSKEQEKQKQKEAFANAKENKQQSH LARLRKDGINSPMLKDALNEGNEDLSKRAPILQDKKDESARTDQKEYVEQLLKQPNNQ QQTDDASLQHEEESTSNRAPVLQENEKDTERTDQKAYIYDEQNQNLETDQQQDFEVQK DDSVSNSEPVAQEKTAEIKRSDQKVMMNQPEPQLGFESPQSTKVENQPIANNERKIRP SEPAKVHSDGIRVDEKQAVAPAENKTVSREKQPSSQTIKRTEQSVNSFDQVSLNEIAR RSSSKVEDRLRRDERTR*" gene 523546..525993 /gene="conG" /locus_tag="BSU_04960" /old_locus_tag="BSU04960" CDS 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" /experiment="publication(s) with functional evidences, PMID:18305117, 22505685, 24532767, 26013486" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18305117, 22505685, 24532767, 26013486; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: two-domain autolysin withN-acetylmuramidase and DL-endopeptidase activity VirB1" /protein_id="NP_388378.1" /db_xref="EnsemblGenomes-Gn:BSU04970" /db_xref="EnsemblGenomes-Tr:CAB12304" /db_xref="GOA:P96645" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG12115" /db_xref="UniProtKB/Swiss-Prot:P96645" /translation="MISKKVVLPLVFSAPFIFFFVLCIVVVMTISRENQVGDDFIGGG DGEYETVGIAPEVERFRAVFEKYARQEGVFDQVNIIMALTMQESGGRSLDIMQSSESI GLPPNSITDPERSIEVGIKHFKKVFKQAGGDVRLTLQAYNFGSGFIDYVKKNGGKYTK KLALDFSRLQAFKMGWKSYGDPSYVDHVMRYVKGSDKNVKPVKGSMDFYETVMKEALK YEGQPYAWGGSNPETGFDCSGLVQWSFAKAGITLPRTAQEQHGATKKISEKEATAGDL VFFGGTYEGKAITHVGIYVGNGRMFNSNDSGIQYSDLKSGYWRDHLVSFGRIK*" gene 525990..526979 /gene="cwlT" /locus_tag="BSU_04970" /old_locus_tag="BSU04970" CDS 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388379.1" /db_xref="EnsemblGenomes-Gn:BSU04980" /db_xref="EnsemblGenomes-Tr:CAB12305" /db_xref="GOA:P96646" /db_xref="SubtiList:BG12116" /db_xref="UniProtKB/Swiss-Prot:P96646" /translation="MKTHIAWASACLLLVMLTGFFTIGQQTYKIEKLKDKNEVLSEKI KELNHIESTSSASENKAFFEAFFNYSDIDIRYETVKKHTTGKGFDYAFPSRSDQKHTV SVQSELLSLESYSKPLDESHELFLNIVEVATTANSVTTNQVLIVQTTMKKEKDGWLVD NVQVKGNG*" gene 526994..527500 /gene="yddI" /locus_tag="BSU_04980" /old_locus_tag="BSU04980" promotor_-35 527503..527509 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 527523..527542 /Source="Nicolas_upshift_promotors" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 527532 /Source="Nicolas_upshifts" /id="U387" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.464535464535465" /psig="0.997002997002997" /xcortree=555 /SigmaFactorBS="ataatgtgcaggttaagggaaatggataaaaGGTGGAAaaga tcaatttgtTTGTTTATACTAAATATTGAaaaaggaggtaatgtttattttgaaaaac c" /listShort="yddJ" /GFF_Attribute="listLong" CDS 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative lipoprotein of unknown function" /protein_id="NP_388380.1" /db_xref="EnsemblGenomes-Gn:BSU04990" /db_xref="EnsemblGenomes-Tr:CAB12306" /db_xref="InterPro:IPR028075" /db_xref="SubtiList:BG12117" /db_xref="UniProtKB/Swiss-Prot:P96647" /translation="MKNLFIFLSLMMMFVLTACGGSKYDDAIDDVISQYKEHKGNDTE INIKRENAIVRVYEGGKYIQFAFYMPDNSSRELTTFKYYEKFGDKYEKMTDMPGNGEN DRLGLSKKTPDYEEVKGEETELEE*" gene 527563..527943 /gene="yddJ" /locus_tag="BSU_04990" /old_locus_tag="BSU04990" downshifts 527920 /Source="Nicolas_upshifts" /id="D234" /incds=0 /nref=167 /ntot=245 /MaxReadThrough="2.07932" /MaxDrop="5.51482" /score="8.08816145" /energy="-14.7" /TU="NA" /idTUdmin="U383" /TUdmin=0 /isTUend="TRUE" downshifts complement(527996) /Source="Nicolas_upshifts" /id="D235" /incds=0 /nref=51 /ntot=228 /MaxReadThrough="3.21157" /MaxDrop="4.80215" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-110" /isTUend="FALSE" S_feature complement(528019..528133) /Source="Nicolas_S_feature" /locus_tag="new_546051_546165_c" /HighExp="LPhT, Lbtran, Mt0, HiTm, Lbexp, M40t45, M0t45, HPh, dia0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S173" downshifts complement(528062) /Source="Nicolas_upshifts" /id="D236" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="5.69722" /MaxDrop="4.64006" /score="-2.66780619" /energy="-18.7" /TU="U388" /idTUdmin="U388" /TUdmin="-176" /isTUend="FALSE" CDS complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22505685; Product type h :extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: conserved protein of unknown function" /protein_id="NP_388381.1" /db_xref="EnsemblGenomes-Gn:BSU05000" /db_xref="EnsemblGenomes-Tr:CAB12307" /db_xref="GOA:P96648" /db_xref="InterPro:IPR000157" /db_xref="InterPro:IPR035897" /db_xref="SubtiList:BG12118" /db_xref="UniProtKB/Swiss-Prot:P96648" /translation="MDTLKKLKFEANGIIGVLLDYSREPVLTNIIDQFRTSLESNDIE LIRYSLEQLKTWYARNRNEIYKNEFVFNEFEHHETENKIKKFLDELPVVDETEKSSIT HFSSDQNRELEKKIFISHSSKDKIVCNAFVELLEDIGVSSEDIIYTSSPYHGIPGDED IFEYLKKHLFKGAYVFYMLSDNYYDSVYCLNEMGATWVNSNNCSTFILPGFKGEIKGV IDKNKKAFSLEEPIDLFNLKEKILRMYDLTLEDKKWERIKAKFNTKLK*" gene complement(528134..528934) /gene="yddK" /locus_tag="BSU_05000" /old_locus_tag="BSU05000" promotor_-10 complement(528979..528998) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528997) /Source="Nicolas_upshifts" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" promotor_-35 complement(529014..529017) /Source="Nicolas_upshift_promotors" /id="U388" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2317 /SigmaFactorBS="tttatgaattacccaaacaatccagactgctttaaaataaGT AGttagaataggagtctATGTTATATAATTAGATATGaaatgtttacaaacaatggat t" /listShort="yddK, S173" /GFF_Attribute="listLong" /label="promotor_-35" CDS 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" /EC_number="3.1.-.-" /experiment="publication(s) with functional evidences, PMID:16105942, 22505685, 23526881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16105942, 22505685, 23526881; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: response regulator aspartate phosphatase" /protein_id="NP_388382.1" /db_xref="EnsemblGenomes-Gn:BSU05010" /db_xref="EnsemblGenomes-Tr:CAB12308" /db_xref="GOA:P96649" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4I1A" /db_xref="SubtiList:BG12119" /db_xref="UniProtKB/Swiss-Prot:P96649" /translation="MRGVFLDKDKIPYDLVTKKLNEWYTSIKNDQVEQAEIIKTEVEK ELLNMEENQDALLYYQLLEFRHEIMLSYMKSKEIEDLNNAYETIKEIEKQGQLTGMLE YYFYFFKGMYEFRRKELISAISAYRIAESKLSEVEDEIEKAEFFFKVSYVYYYMKQTY FSMNYANRALKIFREYEEYAVQTVRCQFIVAGNLIDSLEYERALEQFLKSLEISKESN IEHLIAMSHMNIGICYDELKEYKKASQHLILALEIFEKSKHSFLTKTLFTLTYVEAKQ QNYNVALIYFRKGRFIADKSDDKEYSAKFKILEGLFFSDGETQLIKNAFSYLASRKMF ADVENFSIEVADYFHEQGNLMLSNEYYRMSIEARRKIKKGEIIDENQPDSIGSSDFK* " gene 529274..530449 /gene="rapI" /locus_tag="BSU_05010" /old_locus_tag="BSU05010" promotor_-35 530129..530136 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 530150..530168 /Source="Nicolas_upshift_promotors" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 530160 /Source="Nicolas_upshifts" /id="U389" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=2790 /SigmaFactorBS="aacaaaattataatgttgctttgatatacTTTAGGAAagggc gatttattGCCGATAAAAGTGATGATAaggaatactcagcgaaattcaaaatattaga g" /listShort="phrI, yddM, S174" /GFF_Attribute="listLong" promotor_-35 530357..530363 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530362 /Source="Nicolas_upshifts" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" promotor_-10 530378..530389 /Source="Nicolas_upshift_promotors" /id="U390" /multdbtbs="SigH" /comp="M8" /sig="SigGF" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=882 /SigmaFactorBS="agtcgctgattattttcatgaacaaggaaatttaatgctctc taatgaatattatCGTATGAgtattgaagcaagaCGAAAAATTAAAaaaggggagatt a" /listShort="phrI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200, 21908671, 22505685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 21908671, 22505685; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: secreted regulator of theactivity of phosphatase RapI" /protein_id="NP_388383.1" /db_xref="EnsemblGenomes-Gn:BSU05020" /db_xref="EnsemblGenomes-Tr:CAB12309" /db_xref="SubtiList:BG12645" /db_xref="UniProtKB/Swiss-Prot:O31492" /translation="MKISRILLAAVILSSVFSITYLQSDHNTEIKVAADRVGA*" gene 530406..530525 /gene="phrI" /locus_tag="BSU_05020" /old_locus_tag="BSU05020" downshifts 530523 /Source="Nicolas_upshifts" /id="D237" /incds=0 /nref=46 /ntot=227 /MaxReadThrough="4.14733" /MaxDrop="5.8523" /score="15.7846721" /energy="-10.4" /TU="U389" /idTUdmin="U390" /TUdmin="-15" /isTUend="TRUE" CDS 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22505685; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="ICEBs1 mobile element: putative helicase" /protein_id="NP_388384.1" /db_xref="EnsemblGenomes-Gn:BSU05030" /db_xref="EnsemblGenomes-Tr:CAB12310" /db_xref="GOA:P96650" /db_xref="SubtiList:BG12120" /db_xref="UniProtKB/Swiss-Prot:P96650" /translation="MGENMFKKEKVTEYIWTILIPTIITFIISWVGSYYNGTSTVSIG QPTKVSGQYITPINISPYHDIKELRITFPQKLDVKQISSNEPINVKSDKNNIGVESNS TFEIAKIVENNSVQLLITTQKKLNDKEIRIDKNGNNISVNYESQIVNPAKKQLINLII TSSIYFIMLNILALIMNKRWDKYYAKMKNEIKEFEDNAKDLDKKSKKKSEELSELRKT LNQAFEETDRIKYHEKKKQILLLAKLNDYKKELTFWRNTIRKVLYELPDGDKKADKLI GTVTSSLKTYGTVEKNEHDYESLKVAAALLNDSDKRS*" gene 530678..531619 /gene="yddM" /locus_tag="BSU_05030" /old_locus_tag="BSU05030" S_feature 531620..531878 /Source="Nicolas_S_feature" /locus_tag="new_549652_549910" /HighExp="HPh, S1, Gly, LoTm, LPh, MG 120, GM-0.1, aero, S2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80510899999999996" /TUshortSig="SigD" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S174" S_feature complement(531891..532207) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S175" downshifts 531920 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" downshifts complement(531952) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" CDS complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" gene complement(532208..533227) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" promotor_-10 complement(532903..532922) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532916) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" promotor_-35 complement(532937..532944) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533016..533020 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533037..533056 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533041 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" S_feature 533042..533486 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" gene 533487..533897 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" S_feature 533898..533967 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 533924 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" CDS complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" gene complement(534020..534469) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" CDS 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" gene 534584..535126 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" promotor_-35 535599..535603 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535620..535639 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535629 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" CDS 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" gene 535679..536443 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" CDS 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" gene 536637..537947 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" S_feature 537970..538529 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" gene 538530..538706 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" CDS 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" gene 538731..539417 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" promotor_-35 539759..539763 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 539778..539797 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 539786 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" CDS 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" gene 539841..540026 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" downshifts 540025 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" CDS 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" gene 540376..540969 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" promotor_-35 541082..541089 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541103..541122 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 541114..541231 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 541114 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" downshifts complement(541149) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" CDS 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" gene 541232..541432 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" S_feature complement(541330..542118) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 541335 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" downshifts 541436 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" misc_RNA complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(541500..541578) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" CDS complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" gene complement(542119..542580) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" S_feature 542589..543134 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(542632) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" promotor_-10 complement(542639..542658) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(542674..542681) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 543101 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" CDS complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" gene complement(543148..543384) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" CDS complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" gene complement(543482..544357) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" CDS 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" gene 544470..545429 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" upshifts complement(544491) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" misc_feature complement(544495..544514) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" gene complement(545582..546454) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" promotor_-10 complement(546547..546552) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(546554..546555) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546559) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 546628..546634 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 546642 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" promotor_-10 546648..546667 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" gene 546681..548069 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" downshifts 548045 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" CDS 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" gene 548179..549471 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" promotor_-35 549480..549486 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 549501..549520 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 549508 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" S_feature 549519..549629 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" gene 549630..550076 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" downshifts 550105 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" promotor_-35 550156..550163 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 550178..550197 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 550179 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" CDS 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" gene 550313..550906 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" downshifts 550949 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" downshifts complement(551025) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" promotor_-35 551038..551045 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 551059 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 551060..551079 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" gene complement(551258..551917) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" promotor_-10 complement(551966..551985) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(551973) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" promotor_-35 complement(551997..552002) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" gene complement(552339..553202) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" promotor_-35 553245..553251 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 553266..553285 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(553267..553286) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 553281 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(553291) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(553301..553308) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" gene 553357..554748 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" promotor_-35 554876..554883 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 554894..554913 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 554908 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" CDS 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" gene 554942..555367 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" S_feature 555368..556622 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" gene complement(555420..555992) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" downshifts complement(555425) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" S_feature complement(555993..556073) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" gene complement(556074..556403) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" misc_feature complement(556420..556439) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(556437) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" misc_feature 556611..556630 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 556624 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" CDS 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" gene 556658..557530 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" downshifts 557417 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" downshifts 557615 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" CDS complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" gene complement(557680..558066) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" downshifts complement(557692) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" S_feature complement(558067..558131) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 558119..558126 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(558120..558139) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558133) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" promotor_-10 558140..558159 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 558143 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" promotor_-35 complement(558154..558161) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" gene 558177..558770 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" CDS complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" gene complement(558914..560101) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" promotor_-35 560237..560241 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 560255 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" promotor_-10 560256..560275 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" gene 560305..560901 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" CDS 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" gene 561015..561200 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" downshifts 561179 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" promotor_-35 561312..561315 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 561322..561508 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 561322 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" promotor_-10 561330..561349 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" gene 561509..561844 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" CDS 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" gene 561857..563164 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" CDS 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" gene 563196..563300 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo CDS 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" gene 563309..563422 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo promotor_-35 563608..563616 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563627..563645 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 563644 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" gene 563662..564447 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" downshifts 563709 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" downshifts 564457 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" CDS complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" gene complement(564504..565424) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" CDS 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" gene 565557..567005 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" CDS complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" gene complement(567123..567746) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" promotor_-10 complement(567770..567789) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 567778..567785 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(567789) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" promotor_-10 567800..567819 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567802 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" promotor_-35 complement(567804..567810) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" gene 567836..568516 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" downshifts 568549 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" CDS complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" gene complement(568596..569039) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" downshifts complement(568601) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(569062..569081) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569086) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" promotor_-35 complement(569095..569102) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" gene complement(569125..569304) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" CDS complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" gene complement(569301..569444) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" promotor_-35 569395..569397 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569413..569432 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569429 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" gene 569712..570935 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" CDS 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" gene 570928..571569 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" downshifts 571563 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(571596..571615) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(571617) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(571629..571636) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 571677..571682 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" gene 571685..573859 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" upshifts 571695 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" promotor_-10 571697..571715 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(572761..572779) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(572761) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(573863..574270) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 573880..573884 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573894 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 573897..573916 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(573908) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" CDS complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" gene complement(574271..575173) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" S_feature complement(575174..575269) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(575249..575268) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(575269) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" promotor_-35 complement(575282..575289) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" gene complement(575375..576064) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" CDS complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" gene complement(576154..576966) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" promotor_-10 complement(576995..577014) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(577008) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" promotor_-35 complement(577030..577037) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" gene complement(577077..577970) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" downshifts complement(577097) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" S_feature complement(577971..578063) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(578044..578063) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578061) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" promotor_-35 complement(578079..578086) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578252..578259 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 578274..578293 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 578280 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" CDS 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" gene 578446..579066 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" promotor_-35 578790..578796 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578801 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" promotor_-10 578810..578828 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" gene 579082..580020 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" promotor_-35 580008..580011 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580026..580045 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580033..580121 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 580033 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" CDS 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" gene 580122..580511 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" downshifts 580502 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" misc_feature 580625..580644 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 580627..580696 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 580627 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" CDS 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" gene 580697..581035 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" downshifts 581023 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" CDS complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" gene complement(581075..581311) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" downshifts complement(581099) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" promotor_-35 581123..581129 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 581144..581155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581155 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(581312..581473) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(581477..581842) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(581517) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" CDS complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" gene complement(581843..582073) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" downshifts 582057 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" promotor_-10 complement(582094..582113) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582111) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" S_feature complement(582113..582196) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(582127..582136) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" gene complement(582197..582874) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" promotor_-10 complement(582845..582856) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582859) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(582871..582877) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(582875..583708) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 582890..582895 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582910..582921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582915 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" CDS 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" gene 582987..583694 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" CDS complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" gene complement(583709..584140) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" CDS complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" gene complement(584153..584395) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" CDS complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" gene complement(584409..584681) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" promotor_-10 complement(584703..584722) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584707) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" promotor_-35 complement(584736..584745) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 584900..584907 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584923..584942 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584931 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" CDS 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" gene 584980..585567 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" CDS 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" gene 585564..585908 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" S_feature 585909..586070 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" gene 586071..586544 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" S_feature 586545..587237 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(586687) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" CDS complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" gene complement(586704..588347) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" S_feature complement(588382..588579) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 588396..588398 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 588415..588433 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 588419 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(588425) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" downshifts 588545 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(588571..588590) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(588583) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" promotor_-35 complement(588603..588610) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(588666) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" CDS complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" gene complement(588667..590043) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" misc_feature complement(590093..590112) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(590108) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" CDS complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" gene complement(590214..590732) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" downshifts complement(590228) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(590758..590777) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(590777) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" promotor_-35 complement(590793..590796) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 590814..590821 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 590836..590855 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 590854 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" CDS 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" gene 590901..591359 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" CDS 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" gene 591356..594013 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" downshifts 594134 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" CDS complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" gene complement(594159..594788) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" downshifts complement(594163) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" CDS complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" gene complement(594804..595298) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" promotor_-10 complement(595290..595309) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595305) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" promotor_-35 complement(595325..595330) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595496..595498 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595514..595533 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 595520..595608 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 595520 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" CDS 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" gene 595609..596817 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" downshifts 596796 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" CDS complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" gene complement(596853..597590) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" S_feature complement(597591..597729) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(597717..597736) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(597729) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" promotor_-35 complement(597750..597757) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 597761..597768 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597782..597801 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 597786 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" CDS 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" gene 597839..598513 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" promotor_-35 598572..598577 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598593..598611 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598599 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" CDS 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" gene 598640..599902 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" downshifts 599876 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" promotor_-35 599974..599981 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599995..600014 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599999 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" CDS 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" gene 600063..601250 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" downshifts 601262 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" CDS complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" gene complement(601289..601999) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" downshifts complement(601315) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" CDS complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" gene complement(602065..603453) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" promotor_-10 complement(603510..603527) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603511) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" S_feature complement(603513..603581) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(603534..603541) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(603571..603589) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(603589) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" promotor_-35 complement(603605..603610) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 603658..603665 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 603679..603698 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 603681..603814 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 603681 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" CDS 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" gene 603815..604186 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" downshifts 604165 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" downshifts complement(604260) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" CDS complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" gene complement(604261..604758) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" CDS complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" gene complement(604776..605258) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" promotor_-35 604931..604938 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 604952..604971 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 604956 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(605287..605306) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605297) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" promotor_-35 complement(605321..605324) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" gene 605341..606318 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" downshifts 606298 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" promotor_-35 606345..606351 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606366..606384 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606374 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-35 606410..606417 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 606430 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" promotor_-10 606431..606450 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" gene 606460..607077 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" downshifts 607064 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" CDS complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" gene complement(607093..608259) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" downshifts complement(607122) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" gene complement(608314..608414) /gene="aswA" /locus_tag="BSU_misc_RNA_8" downshifts complement(608355) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" promotor_-10 complement(608424..608443) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608438) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" promotor_-35 complement(608459..608463) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 608522..608529 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 608543..608562 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 608550 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" gene 608590..608901 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" CDS 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" gene 608901..609233 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" CDS 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" gene 609252..610580 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" CDS 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" gene 610598..611995 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" S_feature 611996..612082 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 612060..612067 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 612081..612100 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 612084 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" CDS 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" gene 612138..612851 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" CDS 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" gene 612880..613779 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" CDS 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" gene 613776..614723 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" CDS 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" gene 614742..615830 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" downshifts 615824 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" CDS complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" gene complement(615891..616619) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo downshifts complement(615941) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" CDS complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" gene complement(616550..616744) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo promotor_-10 complement(616777..616788) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616785) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" promotor_-35 complement(616802..616808) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616863..616870 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616884..616903 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 616886..616986 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 616888 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" downshifts complement(616934) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" upshifts 616946 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" promotor_-35 616954..616961 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616975..616994 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616990..617077 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 616990 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" tRNA 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617078..617154 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" tRNA 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617168..617241 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" rRNA 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 617401..618955 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" rRNA 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 619123..622050 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" rRNA 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622106..622222 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" tRNA 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622236..622312 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" tRNA 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 622373..622449 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" downshifts 622446 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" promotor_-35 622550..622554 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622570..622589 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622574 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" CDS 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" gene 622630..623607 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" CDS 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" gene 623622..624098 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" CDS 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" gene 624079..624768 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" CDS 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" gene 624778..625233 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" CDS 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" gene 625226..626266 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" downshifts 626230 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" CDS complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" gene complement(626496..628424) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" downshifts complement(626513) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" misc_feature 628176..628195 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 628186 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" S_feature 628188..628377 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 628342..628349 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628363..628382 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628379..628549 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 628379 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" promotor_-10 complement(628444..628463) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628456) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" promotor_-35 complement(628477..628484) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" gene 628550..629062 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" CDS 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" gene 629059..629706 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" promotor_no_box 629536..629636 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 629596 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" CDS 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" gene 629728..629901 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" CDS 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" gene 629908..630672 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" downshifts 630652 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" CDS complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" gene complement(630710..630901) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" downshifts complement(630727) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" CDS complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" gene complement(630898..631632) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" promotor_-35 631290..631295 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631310..631328 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631312 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 631631..631632 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 631642..631656 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 631664 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" promotor_-10 complement(631669..631688) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631686..631794 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(631689) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" promotor_-35 complement(631702..631707) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 631768..631774 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 631796..631870 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 631796 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" CDS 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" gene 631871..632155 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" CDS 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" gene 632202..633836 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" S_feature 633837..633929 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 633886 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" CDS complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" gene complement(633924..634052) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo S_feature 633931..635399 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" gene complement(634055..634213) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo CDS complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" gene complement(634258..634386) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo CDS complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" gene complement(634479..634688) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo CDS complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " gene complement(634681..634986) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo CDS 635400..635780 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="NP_388485.1" /db_xref="EnsemblGenomes-Gn:BSU06040" /db_xref="EnsemblGenomes-Tr:CAB12423" /db_xref="SubtiList:BG12785" /db_xref="UniProtKB/Swiss-Prot:O34672" /translation="MLSDNNFVSETLENVQYLLPGAKVIKLRGYSRAHKVYTIAKSPV EKWKVAAGLSGSEIAILIRKGHWIGASIPAGGIVIDIDDSKQGELVKGLLDAQNFHCH CIRTLMGGSLFLRITNMGKRKLNK*" gene 635400..635780 /gene="ydiM" /locus_tag="BSU_06040" /old_locus_tag="BSU06040" S_feature 635781..636038 /Source="Nicolas_S_feature" /locus_tag="new_653813_654070" /HighExp="H2O2, dia15, S1, Heat, G150, Diami, G135, G180, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.1454" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S211" CDS 636039..636311 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage 3 region" /protein_id="YP_003097688.1" /db_xref="EnsemblGenomes-Gn:BSU06048" /db_xref="EnsemblGenomes-Tr:CAX52567" /db_xref="UniProtKB/Swiss-Prot:C0H3W7" /translation="MKAWKVEPYEISKAMELIYKYLLLDKKDFSLEEFYKLTIYAIKW KLEQAQFPLYLESTKKSHQNVIPQPFKIKGNVLYKTVIKNSGDFEE*" gene 636039..636311 /gene="ydzU" /locus_tag="BSU_06048" /old_locus_tag="BSU06048" CDS 636301..636660 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage terminase (fragment); defective prophage 3" /db_xref="PSEUDO:CAX52568.1" /translation="MKNSSSWRVGVIHPFKKLSNIERNSVHYELASNDNGREKKDIVP ASVISPSGSCFSLADNGLVEKEGQKMKLTERQRRFCDFFTETRNTTEATRLAGNKGKN LNRVASQNLSKLDIQTI*" gene 636301..636660 /gene="ydzV" /locus_tag="BSU_06049" /old_locus_tag="BSU06049" /pseudo S_feature 636661..637104 /Source="Nicolas_S_feature" /locus_tag="new_654693_655136" /HighExp="H2O2, dia15, S1, G180, G135, G150, Heat, Diami, S2, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S212" CDS 636946..637161 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative N-terminus of restriction enzyme; defective prophage 3" /db_xref="PSEUDO:SOX90546.1" /translation="MIKFSVILGMIRCSLTHITTKNTVNALKRMIYPKQKPSFFHEFK VLYKLLKKFCIKGIMIKNIRSCMGYFL*" gene 636946..637161 /gene="ydiN" /locus_tag="BSU_06050" /old_locus_tag="BSU06050" /pseudo promotor_-35 637091..637097 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 637106..637190 /Source="Nicolas_S_feature" /locus_tag="new_655138_655222" /HighExp="Diami, H2O2, dia5, dia15, Salt, M40t45, G180, G150, G135, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S213" upshifts 637106 /Source="Nicolas_upshifts" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" promotor_-10 637111..637130 /Source="Nicolas_upshift_promotors" /id="U469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig="0.997002997002997" /xcortree=1874 /SigmaFactorBS="agcaaaaaccttcattctttcatgaatttaaagtattatata agcTACTGAAaaagttttgtataAAAGGTATAATGATAAAGAAcattcgttcttgtat g" /listShort="S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637191..638474 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 12682299, 16014871, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 12682299, 16014871, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); prophage 3 region" /protein_id="NP_388487.1" /db_xref="EnsemblGenomes-Gn:BSU06060" /db_xref="EnsemblGenomes-Tr:CAB12425" /db_xref="GOA:O34939" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12787" /db_xref="UniProtKB/Swiss-Prot:O34939" /translation="MTNFILNENKQLSLAIEDENIENFYIDGTDLVRKIIRRSGSGVT SRVPVLSTQDLENKNLHELYDESWLRMKNRPNTELTTESINIADLFSGCGGLSLGVWE ACRALGINPRFSFACDLNEAALSVYEKNFSPDFSLNESIEKHINGELGAPLTVEEQRI KDKVKKIDFILAGPPCQGHSDLNNHTRRKDPRNALLMRVSRVIELFQPSSVLVENVPG IIHDKSGSFKEFKNHLKTQGYYFDEIVLNAEKLGVSQARRRYFIFASKTPVSSLNQIN EFYSTNSRPISWAISDLVENVGDDIFNTASEHSLENKRRIEYLFENNLFELPNSERPD CHRLKPHSYKSVYGRMYWDRPAPTITRGFGSTGQGRFVHSLLKRTITPHEAARIQFFP DFFNFGDLRRRQYQDVIGNAVPSKLSYLLALHQLR*" gene 637191..638474 /gene="bsuMA" /locus_tag="BSU_06060" /old_locus_tag="BSU06060" CDS 638496..639665 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" /EC_number="2.1.1.37" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-methyltransferase (cytosine-specific); defective prophage 3" /protein_id="NP_388488.1" /db_xref="EnsemblGenomes-Gn:BSU06070" /db_xref="EnsemblGenomes-Tr:CAB12426" /db_xref="GOA:O34680" /db_xref="InterPro:IPR001525" /db_xref="InterPro:IPR018117" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR031303" /db_xref="SubtiList:BG12788" /db_xref="UniProtKB/Swiss-Prot:O34680" /translation="MKVVSLFSGIGGIELGLHQSGHTTEIFCEVDPLAKAVLSKNFPG VKIEDDINEIRELPSCDLVAAGFPCQDLSQAGGKEGIDGSRSGLVKKLFELIEKKEHA NRPPWILIENVPYMLRLNRGKAMSYLTSVLSELGYTWAYRTVDARCFGLPQRRHRVIL LASLFEDPKDVIFSQDHSEPDLDGKPSVVDHSNYYGFYWTEGLRGVGWAREAVPPIKC GSSVGIASPPAVWSPYEDIVGTINIRDAERLQGFPEDWTNITTETGKDIKEGARWRLV GNAVSVRVSKWIGENLSQPKGSISDFEGELVTKTWPSAAWGYGDKKYKVPVSKWVANT EQIAISEFLNHPLKPLSARALNGFLGRAARCTNVNYSDEFINSLERCKDRQLQKV*" gene 638496..639665 /gene="bsuMB" /locus_tag="BSU_06070" /old_locus_tag="BSU06070" downshifts 639671 /Source="Nicolas_upshifts" /id="D293" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="2.10319" /MaxDrop="7.17612" /score="34.7238204" /energy="-15.1" /TU="NA" /idTUdmin="U468" /TUdmin=0 /isTUend="TRUE" downshifts complement(639745) /Source="Nicolas_upshifts" /id="D294" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="2.48582" /MaxDrop="4.12737" /score="11.0887998" /energy="-15.6" /TU="NA" /idTUdmin="U471" /TUdmin=2 /isTUend="TRUE" CDS complement(639761..640030) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; C-terminal part of YdzW; defective prophage 3" /db_xref="PSEUDO:CAX52569.1" /translation="MNLASFGSVKVTTVEDYLTGIERLWKALRNSWAFHSQMFLNVFL KSDPWMCLRLSGTEPKIKFYFRVDESLAETRNPQRIEKEFMELVE*" gene complement(639761..640030) /gene="ydzWc" /locus_tag="BSU_06073" /old_locus_tag="BSU06073" /pseudo CDS complement(639987..640157) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="MSLYEALLSIEEYGYFQEGLRSLTLKGKEGAELIQQTLAAFRSE FGQLWFRQGYHC*" gene complement(639987..640157) /gene="ydzWmc" /locus_tag="BSU_06074" /old_locus_tag="BSU06074" /pseudo CDS complement(640088..640573) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /EC_number="5.4.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="LIATDPDADRLGIAVKNENGEYTVLTGNQTEPLLLHYILTQIKK KGTLPSNGIVLKTIVTSELGREVATSFRVETIGVLTGFKFIARKINGYYKTGEHNFLF GYEESYGYLIGDFVRDKDAVQTDVLAVEVCAYYKKKGFHYTKLSLVLKNMATFRKACA H*" gene complement(640088..640573) /gene="ydzWmb" /locus_tag="BSU_06076" /old_locus_tag="BSU06076" /pseudo promotor_-35 640438..640441 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640456..640475 /Source="Nicolas_upshift_promotors" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640460 /Source="Nicolas_upshifts" /id="U470" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.997002997002997" /xcortree=3091 /SigmaFactorBS="aatcgttttaagaacgatcccattagatggaagtgttcCTTT cttttttatttgggTTAAGATATAGTGGAGCAGAagtggctcggtttgatttccggtt a" /listShort="S214" /GFF_Attribute="listLong" S_feature 640463..640867 /Source="Nicolas_S_feature" /locus_tag="new_658495_658899" /HighExp="Cold, LoTm, C30, T0.30H, HPh, Gly, S0, LPh, UNK1, T1.0H" /AntisenseName="ydzW" /AntisenseCor="0.298083403528066" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S214" CDS complement(640583..640726) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /db_xref="PSEUDO:CAX52572.1" /translation="MALAAMNYKHVAVGKEQEQPALCFPLSPVQMLKNMPRLSWPSGK AAN*" gene complement(640583..640726) /gene="ydzW" /locus_tag="BSU_06077" /old_locus_tag="BSU06077" /pseudo CDS complement(640781..640978) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphoglucomutase; internal part of YdzW" /translation="FAVRHLHGFAGIVVTASHNPPEYNGYKVYGPDGGQLPPSKGPDQ NIAQRWTRHTLNYFRKLKYLR*" gene complement(640781..640978) /gene="ydzW" /locus_tag="BSU_06078" /old_locus_tag="BSU06078" /pseudo CDS complement(640936..641097) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; internal part of YdzW" /translation="DIYTLRKVSAGLAAFIMEAARTLASSAYVFESLRPTTVLSLQYV TFMVLPVLL*" gene complement(640936..641097) /gene="ydzWma" /locus_tag="BSU_06079" /old_locus_tag="BSU06079" /pseudo CDS complement(641082..641189) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative phosphomannomutase; N-terminal part of YdzW; defective prophage 3" /translation="MRKTWKMLFIRNLGYGTGGMRGEIGAGTNRMTSIR*" gene complement(641082..641189) /gene="ydzWn" /locus_tag="BSU_06083" /old_locus_tag="BSU06083" /pseudo S_feature complement(641190..641309) /Source="Nicolas_S_feature" /locus_tag="new_659222_659341_c" /HighExp="LoTm, T4.0H, BC, T5.0H, M9-stat, T3.30H, S2, T3.0H, Sw, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S215" promotor_-10 complement(641300..641319) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(641309) /Source="Nicolas_upshifts" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" S_feature complement(641311..641526) /Source="Nicolas_S_feature" /locus_tag="new_659343_659558_c" /HighExp="LBGstat, T0.30H, M9-stat, T1.0H, T1.30H, Lbtran, T2.0H, LBGtran, T2.30H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.11296" /TUshortSig="SigA" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S216" promotor_-35 complement(641335..641338) /Source="Nicolas_upshift_promotors" /id="U471" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.321678321678322" /psig="0.993006993006993" /xcortree=2932 /SigmaFactorBS="caagagcactcgatttatgtcagaaagtcgtCGTTcgaaaac ctctagacTATATTATAATGAACAATAAtgttattttattgtaggtcaatcataggct g" /listShort="S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 641503..641509 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(641512..641531) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-10" promotor_-10 641522..641541 /Source="Nicolas_upshift_promotors" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(641526) /Source="Nicolas_upshifts" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" upshifts 641528 /Source="Nicolas_upshifts" /id="U473" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig=1 /xcortree=2344 /SigmaFactorBS="taccaattcgatatttgaattggtctctcaaacaaTTCCATC ctctttatttatTATGATACAATTATATTAATtagaaaatacatacatattagcttgt g" /listShort="ydiR, ydiS, ydjA, S217, S218, ydjB, S219, ydjC" /GFF_Attribute="listLong" promotor_-35 complement(641546..641549) /Source="Nicolas_upshift_promotors" /id="U472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.458541458541459" /psig="0.977022977022977" /xcortree=3186 /SigmaFactorBS="tttacccccataaaatcacacaagctaatatgtatgtATTTt ctaattaatataaTTGTATCATAATAAATAAAGaggatggaattgtttgagagaccaa t" /listShort="S216, S215, ydzW, ydzW, ydzW, ydzW, ydzW, ydzW" /listLong="ydzW" /label="promotor_-35" CDS 641591..642532 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814, 15728999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814, 15728999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRA (YdiR); prophage region 3" /protein_id="NP_388490.1" /db_xref="EnsemblGenomes-Gn:BSU06090" /db_xref="EnsemblGenomes-Tr:CAB12428" /db_xref="GOA:O35025" /db_xref="SubtiList:BG12790" /db_xref="UniProtKB/Swiss-Prot:O35025" /translation="MTFIKRLEDAYETLLGNYPAGVSSTSTSKYNEIRKIVSEAFLIG ENEVYVTGTSRRISNLDTRFAQGNQRNKHTRMAVAFISIPSVDDSELDELIIRTRNSA ITTSSKFCNGEERGTIFDGILLFLVFEGETKVYPLAFLVFENDFELKEKAEELIPGIE LKEYPRANQSPAQENNKSAKNEDEESAKSYVVFLDIEEDGSIVEFVEDKDKTYRIGDM IWTASHTNGSSAITRRLEVIEVVENLVVCKIKHKYNEPVDKNSLLKFVNIEQDLISFL DLHPNVQNGSEGFVSGDIVDENATTSSDDLPEDFENN*" gene 641591..642532 /gene="bsuRA" /locus_tag="BSU_06090" /old_locus_tag="BSU06090" CDS 642564..643595 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" /EC_number="3.1.21.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRB (YdiS); prophage region 3" /protein_id="NP_388491.1" /db_xref="EnsemblGenomes-Gn:BSU06100" /db_xref="EnsemblGenomes-Tr:CAB12429" /db_xref="GOA:O34885" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12791" /db_xref="UniProtKB/Swiss-Prot:O34885" /translation="MEISKQTSDLLLSLEKKKGTLPKFSVLRSIPRNRIIYGAPGTGK SNYLEREVGKIFGDNPYVFTRVTFFPGYTYGQFIGAYKPVPIYKKLSGEEEIFSSNFR DKMENFEPMIDYQFVPGPFIDVLIKALKNRYTNFILIIEEINRANAASVFGDIFQLLD RNKNGESDYPVTFGPDIMNYLARNGIKDEMIKLPSNFFIWATMNNADQGVLPLDTAFK RRWSFEYLELEKYRKAVDSWKLSLRYKGHNKVIMWNDFRDIINKRLKGKVPEDKLLGP FFLKESELWNQNVFKNKLLYYLKEDVFKHNPTIDFLNASTFSELIEKYDGSDNIFTFD IDDSSFVSD*" gene 642564..643595 /gene="bsuRB" /locus_tag="BSU_06100" /old_locus_tag="BSU06100" CDS 643598..644995 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" /EC_number="3.1.21.4" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11751814" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type-2 restriction enzyme BsuMI component BsuRC (YdjA); prophage region 3" /protein_id="NP_388492.1" /db_xref="EnsemblGenomes-Gn:BSU06110" /db_xref="EnsemblGenomes-Tr:CAB12430" /db_xref="GOA:O34303" /db_xref="InterPro:IPR018579" /db_xref="SubtiList:BG12792" /db_xref="UniProtKB/Swiss-Prot:O34303" /translation="MDKSSKFFFEDQKYNKERIVRVLGGNLALLKSKGILYEDSSGDL IFNYVGVISNGRNVIFILPKYCNRHLDEHSKRTLFNKLLKIFKKYSGLNKSRESDYFV SELDSDEVSDFMIADYLLNDFSLNGYYQKKFTEYEIDGEGIIDWSKTVNEITPVFSKG VPYYFSTYNEVVQKDEYHLIVKIHKWALSKYFNDFGVILGFTGLEFDKSCDGMKILDY ADFFGSVINKEIVNTYVDRDVKLLKALKTAIDREENQFSKRPTLSLYGTKYFHRVWEE VCKTVFSHVNEYVKKISRPNWINFTDIEVNKEKKTLEPDIIKAFEYRSKEYFLILDAK YYNINFDGKKLEGNPGVEDITKQLLYDKALEKLSRGKTKHNAFLFPSSNSTNTFKVFG SVDFDFLDIAAVTLVYISAEQVYNLYLENKTFSTDDLFKFVSEINKSKKRHSVITSTL YGNMFLFTKRLSDKN*" gene 643598..644995 /gene="bsuRC" /locus_tag="BSU_06110" /old_locus_tag="BSU06110" S_feature 644996..645192 /Source="Nicolas_S_feature" /locus_tag="new_663028_663224" /HighExp="Lbtran, C90, M40t45, HPh, M0t45, LBGtran, aero, Lbstat, BI, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S217" downshifts 645149 /Source="Nicolas_upshifts" /id="D295" /incds=0 /nref=3 /ntot=131 /MaxReadThrough="5.36465" /MaxDrop="3.0162" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1364" /isTUend="FALSE" downshifts 645211 /Source="Nicolas_upshifts" /id="D296" /incds=0 /nref=5 /ntot=69 /MaxReadThrough="4.58628" /MaxDrop="3.49698" /score="7.16368756" /energy="-18.1" /TU="U473" /idTUdmin="U473" /TUdmin="-1302" /isTUend="FALSE" S_feature 645256..645568 /Source="Nicolas_S_feature" /locus_tag="new_663288_663600" /HighExp="dia15, Diami, H2O2, Paraq, dia5, LBGstat, G180, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S218" CDS 645569..645904 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; prophage region 3" /protein_id="NP_388493.1" /db_xref="EnsemblGenomes-Gn:BSU06120" /db_xref="EnsemblGenomes-Tr:CAB12431" /db_xref="SubtiList:BG12793" /db_xref="UniProtKB/Swiss-Prot:O34778" /translation="MLNIKSDRIMTSDPQKFTVDGVRFFQQYLNKIRPDAMEIDNLII NSDIIKEDLIVHVSKMIDRLALYDLHRKRSIDKHFSAAFTVDINDREEFYSANIADVS IDLNESSGV*" gene 645569..645904 /gene="ydjB" /locus_tag="BSU_06120" /old_locus_tag="BSU06120" S_feature 645905..646286 /Source="Nicolas_S_feature" /locus_tag="new_663937_664318" /HighExp="H2O2, dia15, G135, Paraq, G180, G150, Diami, Oxctl, LBGexp, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S219" CDS 646287..646637 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388494.1" /db_xref="EnsemblGenomes-Gn:BSU06130" /db_xref="EnsemblGenomes-Tr:CAB12432" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12794" /db_xref="UniProtKB/Swiss-Prot:O34715" /translation="MVSIFYANRLSYSIWNTIPGKYIREELEQNGVTYNELIKYWDIT DPSQALPKVNKDNVLLISAKHDQYIDLKDADYLWESWGRPTRYVYNCGHSGIVLCRKK LANDTLSFIREKLV*" gene 646287..646637 /gene="ydjC" /locus_tag="BSU_06130" /old_locus_tag="BSU06130" downshifts 646513 /Source="Nicolas_upshifts" /id="D297" /incds=1 /nref=1 /ntot=71 /MaxReadThrough="1.89703" /MaxDrop="2.58458" /score="-4.72838456" /energy="-13.9" /TU="NA" /idTUdmin="U473" /TUdmin=0 /isTUend="TRUE" CDS complement(646743..649232) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" gene complement(646743..649232) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" downshifts complement(646765) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(649246..649265) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(649272) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" promotor_-35 complement(649279..649286) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 649335..649336 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 649351..649433 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 649351 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" promotor_-10 649352..649371 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 649434..650495 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" gene 649434..650495 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" CDS 650569..651960 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" gene 650569..651960 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" promotor_-35 651987..651994 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652008..652027 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652013 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" CDS 652055..653017 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" gene 652055..653017 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" downshifts 653002 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" promotor_-35 653142..653151 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 653158 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" promotor_-10 653164..653179 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 653213..653896 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" gene 653213..653896 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" S_feature 653897..653961 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 653962..654987 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" gene 653962..654987 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" CDS 654987..655751 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" gene 654987..655751 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" CDS 655782..656753 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" gene 655782..656753 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" downshifts 656743 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" downshifts 656787 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" CDS complement(656800..657825) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" gene complement(656800..657825) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" promotor_-10 complement(657857..657876) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657875) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" promotor_-35 complement(657890..657896) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 658085..658092 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 658105 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" S_feature 658107..658409 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 658107..658126 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 658410..659831 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" gene 658410..659831 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" downshifts 659823 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" downshifts complement(659879) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" CDS complement(659879..660919) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" gene complement(659879..660919) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" promotor_-35 660459..660468 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660482..660501 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 660483..661018 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 660483 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" S_feature complement(660920..661214) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 661019..661038 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 661020..661317 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 661020 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" misc_feature complement(661209..661223) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661214) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" promotor_-35 661297 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 661316..661335 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 661319 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" CDS 661358..661729 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" gene 661358..661729 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" downshifts 661715 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" CDS 661795..662841 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" gene 661795..662841 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" downshifts 662815 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" CDS complement(662875..663033) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" gene complement(662875..663033) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" downshifts complement(662891) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" S_feature complement(663090..663222) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(663133) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" CDS complement(663223..663432) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" gene complement(663223..663432) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" promotor_-10 complement(663465..663484) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663476) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(663501) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(663515..664330) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" gene complement(663515..664330) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" promotor_-35 664157..664166 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 664179..664198 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 664179 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(664343..665332) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" gene complement(664343..665332) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" promotor_-10 complement(665197..665215) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665205) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" promotor_-35 complement(665231..665236) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(665354..665369) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665375) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" promotor_-35 complement(665381..665390) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(665430..666971) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" gene complement(665430..666971) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" downshifts complement(665443) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(667002..667021) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(667016) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" promotor_-35 complement(667035..667044) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(667123..668532) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" gene complement(667123..668532) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" downshifts complement(667137) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" CDS complement(668570..668857) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" gene complement(668570..668857) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" misc_feature complement(668573..668592) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(668587) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" promotor_-35 668863..668870 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 668886..668905 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 668887 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" CDS 668930..669802 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" gene 668930..669802 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" downshifts 669767 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" downshifts complement(670042) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" misc_feature 670096..670115 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 670106 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" CDS 670152..671114 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" gene 670152..671114 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" CDS 671114..672310 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" gene 671114..672310 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" CDS 672332..674545 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" gene 672332..674545 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" promotor_-35 674540..674547 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 674562..674581 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 674578..674707 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 674578 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" CDS 674708..676249 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" gene 674708..676249 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" downshifts 676235 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" promotor_-35 676356..676360 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 676376..676395 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 676386 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" misc_RNA 676393..676495 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 676393..676495 /gene="gswC" /locus_tag="BSU_misc_RNA_9" downshifts 676521 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" CDS 676630..677952 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" gene 676630..677952 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" downshifts 677930 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" downshifts 677973 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" promotor_-35 678002..678011 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678022..678162 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 678022 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" promotor_-10 678024..678039 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678163..678966 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" gene 678163..678966 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" downshifts 678951 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" promotor_-35 679034..679041 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679055..679074 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 679061..679124 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 679061 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" CDS 679125..679292 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" gene 679125..679292 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" downshifts 679299 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" promotor_-35 679343..679349 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679364..679382 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 679367..679453 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 679367 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" promotor_-35 679432..679439 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 679453..679472 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 679455 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" CDS 679506..680060 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" gene 679506..680060 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" CDS 680060..680257 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" gene 680060..680257 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" downshifts 680247 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" promotor_-35 680303..680310 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680325..680344 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680327 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" misc_RNA 680337..680439 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" gene 680337..680439 /gene="gswD" /locus_tag="BSU_misc_RNA_10" S_feature 680440..680579 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 680580..681068 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" gene 680580..681068 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" CDS 681061..682203 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" gene 681061..682203 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" CDS 682200..683495 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" gene 682200..683495 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" promotor_-10 complement(682505..682524) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682526) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(682539..682546) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 683569..684294 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" gene 683569..684294 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" CDS 684287..684541 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" gene 684287..684541 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" CDS 684538..685221 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" gene 684538..685221 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" CDS 685205..687433 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" gene 685205..687433 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" downshifts complement(685453) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" CDS 687409..688839 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" gene 687409..688839 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" S_feature 688840..688940 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 688941..689981 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" gene 688941..689981 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" CDS 689978..690565 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" gene 689978..690565 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" misc_feature 689988..690002 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 689997 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" promotor_-10 complement(690264..690282) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(690271) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(690298..690303) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 690562..692100 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" gene 690562..692100 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" CDS 692116..693384 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" gene 692116..693384 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" downshifts 693369 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" CDS complement(693424..693843) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" gene complement(693424..693843) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" misc_feature complement(693913..693932) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(693922) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" CDS 693987..695261 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" gene 693987..695261 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" downshifts 695210 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" CDS complement(695276..695503) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" gene complement(695276..695503) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" downshifts complement(695287) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" S_feature complement(695504..695924) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 695571..695576 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 695587 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" promotor_-10 695590..695609 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 695632..697374 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" gene 695632..697374 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" promotor_-10 complement(695909..695920) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(695924) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" promotor_-35 complement(695934..695940) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 695955 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" promotor_-35 697348..697354 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 697366 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" promotor_-10 697367..697386 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 697401..698396 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" gene 697401..698396 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" CDS 698399..698713 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" gene 698399..698713 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" downshifts 698576 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" downshifts 698718 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" CDS complement(698748..700325) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" gene complement(698748..700325) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" downshifts complement(698762) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(700339..700358) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(700358) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" promotor_-35 complement(700373..700379) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 700522..700525 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 700539 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" promotor_-10 700542..700561 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 700590..701276 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" gene 700590..701276 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" CDS 701338..703557 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " gene 701338..703557 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" CDS 703581..705587 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" gene 703581..705587 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" CDS 705603..706793 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" gene 705603..706793 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" misc_feature complement(705798..705802) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(705802) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 706830..706849 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 706838..706954 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 706838 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" downshifts complement(706902) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" CDS 706955..707965 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" gene 706955..707965 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" promotor_no_box complement(706972..707072) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(707012) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 707948 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" S_feature 707992..708796 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(708003..708701) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" gene complement(708003..708701) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" downshifts complement(708024) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(708721..708739) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708742) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" promotor_-35 complement(708755..708760) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(708808..710286) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" gene complement(708808..710286) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" downshifts complement(708822) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" upshifts complement(709674) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" misc_feature complement(709677..709690) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(710287..710417) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(710408..710426) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710417) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" promotor_-35 complement(710441..710447) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710548..710551 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 710566..710699 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 710566 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" promotor_-10 710568..710587 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710700..710990 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" gene 710700..710990 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" CDS 711006..712463 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" gene 711006..712463 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" CDS 712477..713907 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" gene 712477..713907 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" downshifts 713888 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" CDS complement(713922..714791) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" gene complement(713922..714791) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" downshifts complement(713964) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" promotor_-35 714581..714586 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 714602..714620 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 714614 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" S_feature complement(714792..714866) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 714844..714851 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(714860..714879) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 714866 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" promotor_-10 714867..714886 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714873) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" promotor_-35 complement(714894..714901) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714923..718081 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" gene 714923..718081 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" downshifts 718068 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" promotor_-35 718320..718323 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 718338..718357 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 718346 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" CDS 718404..719315 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" gene 718404..719315 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" S_feature 719316..719570 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 719571..720950 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" gene 719571..720950 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" S_feature 720951..721543 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(720963..721865) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" gene complement(720963..721865) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" downshifts 721500 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" S_feature 721545..721845 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 721846..722181 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" gene 721846..722181 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" S_feature 722182..722255 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 722256..724895 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" gene 722256..724895 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" CDS 724907..726706 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" gene 724907..726706 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" promotor_-10 complement(725147..725162) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(725162) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(725174..725183) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 726707..726818 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 726819..727967 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" gene 726819..727967 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" S_feature 727968..729157 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(728229..728534) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " gene complement(728229..728534) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" CDS complement(728601..728807) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" gene complement(728601..728807) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" CDS complement(729047..729502) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" gene complement(729047..729502) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" downshifts complement(729060) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" CDS complement(729522..731531) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" gene complement(729522..731531) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" promotor_-10 complement(729889..729908) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(729896) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" promotor_-35 complement(729921..729926) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(731558..731577) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(731568) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" CDS 731743..732765 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" gene 731743..732765 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" promotor_-35 732865..732872 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 732886..732905 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 732887 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" CDS 732927..734057 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" gene 732927..734057 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" CDS 734047..734220 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" gene 734047..734220 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" downshifts 734175 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" S_feature 734221..734325 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 734292..734299 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734314..734333 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 734327 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" CDS 734380..735099 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" gene 734380..735099 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" downshifts complement(734382) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" promotor_-35 734957..734964 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734978..734997 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 734988 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" downshifts 735081 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" promotor_-35 735168..735177 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 735191..735210 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 735194 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" promotor_-10 complement(735198..735216) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735218) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(735232..735237) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 735233..735670 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" gene 735233..735670 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" downshifts complement(735240) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" downshifts 735670 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" promotor_-35 735730..735737 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 735753..735772 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 735758 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" CDS 735785..736369 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" gene 735785..736369 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" downshifts 736350 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" CDS 736448..736891 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" gene 736448..736891 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" CDS 736888..737748 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" gene 736888..737748 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" promotor_-35 737810..737815 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737831..737849 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737831 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" promotor_-10 complement(737853..737867) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(737858) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(737875..737879) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 737875..738123 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" gene 737875..738123 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" CDS 738107..738370 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" gene 738107..738370 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" CDS 738385..738954 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" gene 738385..738954 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" S_feature 738955..739033 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 739006..739011 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 739026..739045 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 739035 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" CDS 739079..739621 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" gene 739079..739621 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" downshifts 739588 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" CDS 739644..739946 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" gene 739644..739946 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" promotor_-35 739989..739997 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740008..740026 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740014 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" CDS 740061..740690 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" gene 740061..740690 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" CDS 740687..742420 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" gene 740687..742420 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" CDS 742420..743526 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" gene 742420..743526 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" downshifts 743480 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" promotor_-35 743565..743568 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743583..743602 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 743590 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 743630..744913 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" gene 743630..744913 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" CDS 744910..745839 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" gene 744910..745839 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" CDS 745843..746733 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" gene 745843..746733 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" CDS 746749..747783 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" gene 746749..747783 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" CDS 747806..750091 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" gene 747806..750091 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" CDS 750105..750803 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" gene 750105..750803 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" CDS 750796..751458 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" gene 750796..751458 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" CDS 751455..752081 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" gene 751455..752081 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" CDS 752202..754064 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" gene 752202..754064 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" promotor_no_box 752242..752342 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 752302 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(752840) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(752841..752860) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(752873..752882) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 754110..755948 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" gene 754110..755948 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" CDS 756106..756759 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " gene 756106..756759 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" CDS 756767..758758 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" gene 756767..758758 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" CDS 758802..761375 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" gene 758802..761375 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" promotor_-10 complement(760124..760142) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760137) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(760158..760163) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 761497..763005 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" gene 761497..763005 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" CDS 763060..764016 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" gene 763060..764016 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" downshifts complement(763334) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" promotor_no_box complement(763360..763460) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(763400) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 764030..764917 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" gene 764030..764917 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" promotor_-35 764664..764669 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764685..764703 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764688 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" CDS 764926..766266 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" gene 764926..766266 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" S_feature complement(765360..767051) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 766267..766348 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 766349..767044 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" gene 766349..767044 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" downshifts 767042 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" CDS complement(767081..767407) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" gene complement(767081..767407) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" downshifts complement(767096) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" downshifts 767394 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" promotor_-10 complement(767430..767449) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767448) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" promotor_-35 complement(767464..767471) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(767511..767873) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" gene complement(767511..767873) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" promotor_-10 complement(767896..767915) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(767910) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" promotor_-35 complement(767928..767934) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(767944..768504) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(767976) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(768487..768506) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768504) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" promotor_-35 complement(768520..768529) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768592..768599 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 768608 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" promotor_-10 768612..768631 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 768657..769238 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" gene 768657..769238 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo CDS 769232..769528 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" gene 769232..769528 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo downshifts 769520 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" promotor_-35 769599..769606 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769620..769639 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769628 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" CDS 769683..769850 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" gene 769683..769850 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" promotor_-35 769892..769899 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769915..769934 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769916 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" CDS 769960..770604 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" gene 769960..770604 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" downshifts 770540 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" downshifts 770584 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" CDS 770604..771596 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" gene 770604..771596 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" downshifts 771530 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" downshifts 771574 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" CDS complement(771620..772123) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" gene complement(771620..772123) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" promotor_-10 complement(772148..772167) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772156) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" promotor_-35 complement(772181..772188) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 772286..773395 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" gene 772286..773395 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" downshifts 773378 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" CDS complement(773430..774500) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" gene complement(773430..774500) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" downshifts complement(773454) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(774531..774550) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774557) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" promotor_-35 complement(774565..774572) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774580..774586 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774601..774619 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774610 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" CDS 774650..777835 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" gene 774650..777835 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" downshifts 777822 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" promotor_-35 777885..777890 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777906..777924 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777927 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" promotor_-35 777955..777958 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777975..777994 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 777976..778281 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 777976 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" CDS 778282..780201 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" gene 778282..780201 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" downshifts 780200 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" promotor_-35 780289..780298 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 780308..780436 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 780308 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" promotor_-10 780312..780331 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(780362) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" CDS 780437..781201 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" gene 780437..781201 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" CDS 781208..782176 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" gene 781208..782176 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" CDS 782200..783111 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" gene 782200..783111 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" promotor_-35 782989..782998 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783011..783030 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783014 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" CDS 783140..784318 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" gene 783140..784318 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" promotor_-35 783859..783865 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783880..783899 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783894 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 784319..785254 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" gene 784319..785254 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" downshifts 785126 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" downshifts 785236 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" downshifts complement(785277) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" CDS complement(785285..786514) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" gene complement(785285..786514) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" promotor_-10 complement(786543..786562) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786561) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" promotor_-35 complement(786578..786585) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(786625..787332) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" gene complement(786625..787332) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" downshifts complement(786654) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" misc_feature complement(787355..787374) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(787378) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" CDS complement(787424..788809) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" gene complement(787424..788809) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" downshifts complement(787446) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(788858..788877) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(788875) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" promotor_-35 complement(788892..788899) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 788977..788984 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 788992 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" promotor_-10 788998..789016 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789059..790516 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" gene 789059..790516 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" promotor_-10 complement(789852..789871) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789866) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(789884..789893) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 790530..791390 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" gene 790530..791390 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" downshifts 791374 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" promotor_-35 791458..791465 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 791479..791498 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 791484 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" CDS 791525..793414 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" gene 791525..793414 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" downshifts 793398 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" misc_feature 793478..793497 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 793486 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" CDS 793537..793983 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" gene 793537..793983 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" downshifts complement(793539) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(793623..793626) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793628) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(793644..793645) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 793970 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" promotor_-35 794046..794053 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794067..794086 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794079 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" CDS 794108..794530 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" gene 794108..794530 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" downshifts 794366 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" CDS 794596..795786 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" gene 794596..795786 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" downshifts complement(795850) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" CDS 796077..796232 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" gene 796077..796232 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" CDS complement(796352..797908) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" gene complement(796352..797908) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" downshifts complement(796376) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" promotor_-35 797738..797744 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 797759..797770 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 797776 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" promotor_-10 complement(797958..797977) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(797962) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" promotor_-35 complement(797993..797997) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 798018..798021 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798037..798056 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798040 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" CDS 798081..799211 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" gene 798081..799211 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" downshifts 799194 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" CDS 799279..799725 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" gene 799279..799725 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" CDS complement(799778..800797) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" gene complement(799778..800797) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" downshifts complement(799788) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(800818..800837) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(800822) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" S_feature complement(800824..801278) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(800850..800857) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 800916..800923 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800937..800956 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800944..802041 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 800944 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" CDS complement(801279..802499) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" gene complement(801279..802499) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" promotor_-10 complement(802536..802555) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(802543) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" promotor_-35 complement(802571..802578) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 802597..802604 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 802616..802791 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 802616 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" promotor_-10 802619..802638 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 802748 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" CDS 802835..804298 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" gene 802835..804298 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" S_feature complement(803200..804870) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 804299..804792 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 804780..804785 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 804794..808059 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 804794 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" promotor_-10 804801..804819 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(804871..805671) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" gene complement(804871..805671) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" CDS complement(805684..806685) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " gene complement(805684..806685) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" promotor_-10 complement(806271..806290) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(806283) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(806305..806312) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(806682..807683) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " gene complement(806682..807683) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" misc_feature complement(807753..807772) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(807755..808702) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" gene complement(807755..808702) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" downshifts complement(807774) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" upshifts complement(807774) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" promotor_-35 808029..808034 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 808050..808068 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 808061..808686 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 808061 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" misc_feature 808682..808701 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 808688..809219 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 808688 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" promotor_-10 complement(808744..808763) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(808751) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" promotor_-35 complement(808777..808784) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(808811..809179) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" gene complement(808811..809179) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" S_feature complement(809180..809292) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(809281..809300) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(809292) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" promotor_-35 complement(809312..809319) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 809360..809366 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809380..809398 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809380 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" CDS 809423..809770 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" gene 809423..809770 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" downshifts complement(809424) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" downshifts 809766 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" S_feature 809811..809891 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 809892..809911 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 809893 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" CDS 809961..811223 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" gene 809961..811223 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" downshifts 811218 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" promotor_-35 811276..811279 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811294..811313 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811302 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" CDS 811350..812786 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" gene 811350..812786 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" downshifts 812778 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" misc_feature 812877..812896 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 812888 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" CDS 812913..814541 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" gene 812913..814541 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" CDS 814513..815193 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" gene 814513..815193 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" CDS 815196..816155 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" gene 815196..816155 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" downshifts 816124 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" promotor_-35 816247..816254 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 816267..816286 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 816278..816350 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 816278 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" CDS 816351..817652 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" gene 816351..817652 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" promotor_-35 817649..817655 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817669..817680 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817670 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" CDS 817708..818502 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" gene 817708..818502 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" downshifts 818478 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" promotor_-35 818557..818560 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818575..818594 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818588 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" CDS 818621..819712 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" gene 818621..819712 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" CDS complement(819703..819978) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" gene complement(819703..819978) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" S_feature 819713..820044 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(819992..820011) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820006) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" promotor_-35 complement(820026..820033) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 820045..820710 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" gene 820045..820710 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" CDS complement(820751..820888) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" gene complement(820751..820888) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" downshifts complement(820765) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" S_feature complement(820889..821019) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(821005..821023) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 821015..821020 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(821019) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" S_feature 821030..822094 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 821031 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" promotor_-10 821036..821054 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(821039..821044) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(821045..821200) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" gene complement(821045..821200) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" S_feature complement(821201..821306) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(821307..821621) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" gene complement(821307..821621) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" S_feature complement(821622..821702) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(821703..822452) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" gene complement(821703..822452) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" promotor_-10 complement(822481..822500) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(822494) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" S_feature complement(822496..823632) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(822512..822520) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 822563..822564 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 822584..822603 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 822587 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" CDS 822624..823982 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" gene 822624..823982 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" promotor_-10 complement(823618..823637) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(823632) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" promotor_-35 complement(823651..823660) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 823868 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" downshifts 823978 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" CDS complement(824015..825964) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" gene complement(824015..825964) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" downshifts complement(824032) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" promotor_-35 825074..825080 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825096..825114 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825100..826064 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 825100 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" S_feature complement(825965..826039) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(826016..826035) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826039) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" S_feature complement(826041..826563) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(826051..826055) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 826065..826202 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" gene 826065..826202 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" upshifts 826180 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" misc_feature 826181..826200 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 826221..826613 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" gene 826221..826613 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" promotor_-10 complement(826561..826579) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826576) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" promotor_-35 complement(826595..826600) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 826682..826688 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826703..826721 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 826703 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" CDS 826738..828153 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" gene 826738..828153 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" downshifts complement(826739) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" promotor_no_box complement(826765..826865) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(826805) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(828150..829226) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" gene complement(828150..829226) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" S_feature 828154..831520 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(829250..829450) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" gene complement(829250..829450) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" CDS complement(829466..830620) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" gene complement(829466..830620) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" CDS complement(830601..832142) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" gene complement(830601..832142) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" promotor_-10 complement(832192..832203) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832195) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" promotor_-35 complement(832217..832223) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 832252..832259 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832274..832293 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832281 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" downshifts complement(832327) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" CDS 832335..833747 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" gene 832335..833747 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" promotor_no_box complement(832353..832453) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(832393) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 833818..835503 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" gene 833818..835503 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" promotor_-10 complement(834124..834139) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834131) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(834152..834161) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 835476..835480 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835496..835515 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835499 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" CDS 835524..836240 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" gene 835524..836240 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" downshifts 836233 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" promotor_-35 836315..836318 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836334..836353 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836343 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" CDS 836380..837045 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" gene 836380..837045 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" downshifts 837026 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" CDS complement(837082..841470) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" gene complement(837082..841470) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" downshifts complement(837101) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(841503..841522) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841520) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" promotor_-35 complement(841537..841540) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 841647..841653 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 841667..841685 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 841670 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 841713..842231 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" gene 841713..842231 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" downshifts 842217 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" downshifts complement(842261) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" S_feature 842262..843912 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(842271..843461) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" gene complement(842271..843461) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" S_feature complement(843462..843553) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(843554..843769) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" gene complement(843554..843769) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" downshifts complement(843613) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(843801..843820) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(843815) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" promotor_-35 complement(843835..843836) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 843882..843889 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843904..843923 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843914 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" CDS 843972..844442 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" gene 843972..844442 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" CDS 844460..844780 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" gene 844460..844780 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" CDS 844804..845631 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " gene 844804..845631 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" promotor_-35 845610..845616 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 845631..845642 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 845649..845805 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 845649 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" downshifts complement(845681) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" downshifts 845780 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" CDS complement(845830..847005) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " gene complement(845830..847005) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" downshifts complement(845835) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" promotor_-35 846442..846448 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846464..846482 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846468..847121 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 846468 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" promotor_-10 complement(847030..847049) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(847045) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" promotor_-35 complement(847063..847070) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 847111..847116 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 847123 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" promotor_-10 847131..847149 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 847173..848228 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" gene 847173..848228 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" promotor_-35 848242..848248 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848263..848274 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 848267 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" CDS 848299..849093 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" gene 848299..849093 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" downshifts 849081 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" CDS complement(849132..849974) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" gene complement(849132..849974) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" downshifts complement(849134) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" CDS complement(849975..851096) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" gene complement(849975..851096) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" promotor_-10 complement(851137..851156) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(851155) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" promotor_-35 complement(851172..851176) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 851184..851191 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851205..851224 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851215 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" CDS 851241..851426 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" gene 851241..851426 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" downshifts 851405 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" promotor_-35 851469..851475 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 851481 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" promotor_-10 851490..851501 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 851527..852318 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" gene 851527..852318 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" downshifts 852316 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" CDS complement(852356..853216) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" gene complement(852356..853216) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" downshifts complement(852370) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(853236..853255) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(853250) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" promotor_-35 complement(853271..853274) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(853315..854274) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" gene complement(853315..854274) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" downshifts complement(853338) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(854285..854304) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854288) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" promotor_-35 complement(854320..854323) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 854335..854339 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854353..854372 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854362 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" CDS 854393..855256 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" gene 854393..855256 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" S_feature 855257..855369 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 855370..856770 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" gene 855370..856770 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" downshifts 856782 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" promotor_-35 857076..857083 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857099..857118 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857105 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" S_feature 857112..857395 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 857396..857662 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" gene 857396..857662 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" promotor_-10 complement(857610..857629) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857628) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(857644..857647) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 857663..858144 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 858115..858118 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 858135..858154 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 858146..858393 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 858146 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" CDS 858394..859371 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" gene 858394..859371 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" S_feature 859372..859464 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 859421 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" promotor_-35 859505..859511 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859523..859542 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859532 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" CDS 859567..860019 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" gene 859567..860019 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" CDS 860049..860738 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" gene 860049..860738 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" downshifts 860743 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" misc_feature 860915..860933 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 860922 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" CDS 860970..861971 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " gene 860970..861971 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" CDS 861975..863003 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" gene 861975..863003 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" CDS 863017..864213 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" gene 863017..864213 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" downshifts complement(863018) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" CDS 864234..865610 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" gene 864234..865610 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" downshifts 865604 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" promotor_-35 865657..865664 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 865677..865696 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 865685 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" CDS 865726..867543 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" gene 865726..867543 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" promotor_-35 867544..867550 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 867562 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" promotor_-10 867565..867576 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 867597..867776 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" gene 867597..867776 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" downshifts 867760 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" CDS complement(867812..868141) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" gene complement(867812..868141) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" downshifts complement(867826) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" CDS complement(868191..868649) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" gene complement(868191..868649) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" S_feature complement(868650..868742) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(868743..869300) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" gene complement(868743..869300) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" promotor_-35 869166..869171 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 869179 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" promotor_-10 869186..869204 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869190..869777 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(869332..870099) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" gene complement(869332..870099) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" CDS complement(870111..871334) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" gene complement(870111..871334) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" CDS complement(871340..871654) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" gene complement(871340..871654) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" promotor_-10 complement(871702..871721) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(871715) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" promotor_-35 complement(871736..871739) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 871946..871965 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 871949 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" CDS 871990..873339 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " gene 871990..873339 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" misc_feature 873368..873387 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 873370 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" CDS 873404..874168 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" gene 873404..874168 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" promotor_-10 complement(873548..873562) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(873578..873584) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(873578) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 874183..875766 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" gene 874183..875766 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" downshifts 875746 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" promotor_-35 875795..875802 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875817..875836 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875825 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" CDS 875872..877593 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" gene 875872..877593 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" CDS 877587..879401 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" gene 877587..879401 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" downshifts 879376 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" promotor_-35 879483..879490 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879504..879523 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879508 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" CDS 879556..879960 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" gene 879556..879960 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" CDS 879978..880835 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" gene 879978..880835 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" downshifts 880822 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" CDS 880929..881873 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" gene 880929..881873 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" downshifts complement(881740) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" promotor_no_box complement(881788..881888) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(881828) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 882048..883496 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" gene 882048..883496 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" CDS 883523..884464 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" gene 883523..884464 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" CDS 884474..885655 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" gene 884474..885655 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" downshifts 885645 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" promotor_-35 885715..885721 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885736..885755 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885754 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" CDS 885779..886981 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" gene 885779..886981 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" CDS 886978..887640 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" gene 886978..887640 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" downshifts 887648 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" CDS 887784..888719 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" gene 887784..888719 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" CDS 888732..889922 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" gene 888732..889922 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" CDS 889936..891093 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" gene 889936..891093 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" promotor_-35 890047..890052 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890067..890085 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890068 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(891091..891165) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(891134) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" CDS complement(891166..891714) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" gene complement(891166..891714) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" S_feature complement(891715..891794) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(891783..891802) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891794) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" promotor_-35 complement(891816..891821) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891917..891920 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891936..891955 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891943 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" CDS 891987..892619 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" gene 891987..892619 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" downshifts 892598 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" promotor_-35 892734..892739 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 892753..892772 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 892763 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" CDS 892808..893896 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" gene 892808..893896 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" S_feature complement(893298..893686) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(893686) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" promotor_-10 complement(893688..893707) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(893720..893728) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(893932..894549) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" gene complement(893932..894549) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" downshifts complement(893950) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" CDS complement(894515..895768) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" gene complement(894515..895768) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" promotor_-10 complement(894576..894595) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(894588) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" promotor_-35 complement(894609..894616) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(895802..895821) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(895820) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(895836..895843) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 895847..895866 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 895852 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" CDS 895892..896428 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" gene 895892..896428 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" CDS complement(896425..897981) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" gene complement(896425..897981) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" promotor_-10 complement(898003..898021) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898020) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(898037..898040) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(898092..898574) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" gene complement(898092..898574) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" downshifts complement(898108) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(898599..898618) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898615) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" promotor_-35 complement(898633..898639) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 898660..898667 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898681..898700 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898689 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" CDS 898746..901316 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" gene 898746..901316 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" downshifts 901287 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" CDS complement(901334..902311) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" gene complement(901334..902311) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" downshifts complement(901345) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" promotor_-35 902326..902333 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(902338..902357) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 902348..902367 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 902350..902441 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 902350 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" upshifts complement(902355) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" promotor_-35 complement(902372..902379) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 902442..903443 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " gene 902442..903443 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" CDS 903440..904471 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" gene 903440..904471 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" downshifts 904452 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" promotor_-35 904522..904524 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904540..904559 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904543 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" CDS 904586..905467 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" gene 904586..905467 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" promotor_-35 905478..905485 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 905501..905520 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 905510 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" CDS 905555..906139 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" gene 905555..906139 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" downshifts 906126 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" CDS complement(906178..906369) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" gene complement(906178..906369) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" downshifts complement(906196) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" upshifts complement(906401) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" promotor_-10 complement(906404..906415) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(906430..906436) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(906436..906546) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" gene complement(906436..906546) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" promotor_-10 complement(906575..906586) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(906577) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(906601..906607) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(906601..907512) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" gene complement(906601..907512) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" promotor_-35 907398..907401 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 907418..907437 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 907428..907600 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 907428 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" promotor_-10 complement(907534..907552) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(907548) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" promotor_-35 complement(907566..907572) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 907601..908395 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" gene 907601..908395 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" CDS 908397..908711 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" gene 908397..908711 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" S_feature complement(908619..908887) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 908701 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" promotor_-35 908785..908790 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908806..908825 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908811 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" CDS 908854..910047 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" gene 908854..910047 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" S_feature 910048..910282 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(910080..910232) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" gene complement(910080..910232) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" downshifts complement(910097) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" promotor_-35 910261..910268 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910282..910301 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910284..910356 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 910284 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" promotor_-10 complement(910291..910302) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(910301) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" promotor_-35 complement(910317..910323) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 910357..910626 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" gene 910357..910626 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" downshifts 910615 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" promotor_-35 910704..910710 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 910725 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 910726..910744 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 910771..911289 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" gene 910771..911289 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" S_feature 911290..911357 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 911325..911334 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 911346..911361 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 911359 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" CDS 911374..911706 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" gene 911374..911706 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" CDS 911693..912553 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" gene 911693..912553 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" downshifts 912551 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" promotor_-35 912611..912617 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 912631..912642 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 912639..912703 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 912639 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" promotor_-10 complement(912661..912680) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(912670) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 912686..912692 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(912694..912695) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 912705..912785 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 912705 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" promotor_-10 912707..912725 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 912786..913775 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" gene 912786..913775 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" upshifts complement(912935) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(912940..912944) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(912961..912965) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 913776..913846 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 913847..916432 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" gene 913847..916432 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" downshifts 916401 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" CDS complement(916425..917408) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" gene complement(916425..917408) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" downshifts complement(916459) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" promotor_-35 916882..916891 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916904..916923 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916908 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(917409..917556) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 917513..917517 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917533..917552 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917540 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 917546..917623 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(917554..917573) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917556) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" promotor_-35 complement(917588..917595) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917624..918733 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" gene 917624..918733 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" promotor_-35 918570..918574 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 918590..918609 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 918602 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" S_feature 918734..919046 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(918741..918965) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" gene complement(918741..918965) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" promotor_-10 complement(918995..919006) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(918997) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" promotor_-35 complement(919020..919026) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 919047..919799 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" gene 919047..919799 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" promotor_-35 919816..919822 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919837..919848 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 919838 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" promotor_-10 complement(919845..919859) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(919866) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(919868..919872) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 919868..920122 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" gene 919868..920122 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" downshifts 920120 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" downshifts complement(920145) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" CDS 920211..920555 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" gene 920211..920555 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" promotor_-35 920218..920226 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920237..920255 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920239 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" downshifts 920538 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" promotor_-35 920594..920601 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920615..920634 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920624..920698 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 920624 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" CDS 920699..921229 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" gene 920699..921229 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" downshifts 921220 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" CDS 921317..923059 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" gene 921317..923059 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" downshifts 923046 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" CDS complement(923136..924197) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" gene complement(923136..924197) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" downshifts complement(923147) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" S_feature complement(924198..924288) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(924286..924305) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(924295) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" promotor_-35 complement(924320..924327) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(924417..925706) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" gene complement(924417..925706) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" downshifts complement(924420) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(925734..925753) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925753) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" S_feature complement(925755..926466) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(925765..925770) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 925799..925806 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925820..925839 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925820 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" CDS 925859..926332 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" gene 925859..926332 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" promotor_-35 926369..926376 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926391..926410 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926397 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" CDS 926455..926892 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" gene 926455..926892 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" downshifts 926874 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" CDS complement(926927..927280) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" gene complement(926927..927280) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" downshifts 926940 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" downshifts complement(926950) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" promotor_-35 927276..927280 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 927288..927302 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(927292..927311) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 927292..927383 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 927292 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" upshifts complement(927302) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" promotor_-35 927360..927363 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 927378..927397 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 927385..927487 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 927385 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" CDS 927488..928372 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" gene 927488..928372 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" promotor_-35 928355..928362 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928376..928395 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 928391..928663 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 928391 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" downshifts complement(928424) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" rRNA 928664..930218 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 928664..930218 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" rRNA 930386..933313 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 930386..933313 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" S_feature 933314..933399 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 933375..933382 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 933396..933415 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 933401 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" rRNA 933425..933540 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933425..933540 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" tRNA 933550..933624 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933550..933624 /gene="asnTA" /locus_tag="BSU_tRNA_29" tRNA 933630..933721 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933630..933721 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" downshifts 933717 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" tRNA 933756..933827 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933756..933827 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" tRNA 933837..933912 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933837..933912 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" tRNA 933922..933998 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 933922..933998 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" tRNA 934010..934086 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934010..934086 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" tRNA 934099..934174 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934099..934174 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" tRNA 934180..934252 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934180..934252 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" tRNA 934275..934359 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934275..934359 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" tRNA 934365..934438 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934365..934438 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" tRNA 934463..934538 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934463..934538 /gene="trnD-His" /locus_tag="BSU_tRNA_39" tRNA 934548..934619 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934548..934619 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" tRNA 934669..934743 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934669..934743 /gene="glyTB" /locus_tag="BSU_tRNA_41" tRNA 934749..934819 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934749..934819 /gene="cysTA" /locus_tag="BSU_tRNA_42" tRNA 934827..934915 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 934827..934915 /gene="leuTA" /locus_tag="BSU_tRNA_43" S_feature 934916..934992 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 934949 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" S_feature 934994..935162 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 935119..935126 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 935125 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" promotor_-10 935140..935159 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935164 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" tRNA 935181..935262 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 935181..935262 /gene="leuTB" /locus_tag="BSU_tRNA_44" promotor_-10 complement(935198..935215) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935201) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(935236..935241) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(935271) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" CDS complement(935341..936117) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" gene complement(935341..936117) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" downshifts complement(935355) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(936144..936159) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936166) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" promotor_-35 complement(936172..936181) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 936201..936207 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936222..936233 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936225 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" CDS 936259..936462 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" gene 936259..936462 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" downshifts 936445 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" downshifts complement(936521) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" CDS complement(936547..936819) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" gene complement(936547..936819) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" promotor_-10 complement(936778..936796) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936785) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" promotor_-35 936800..936807 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(936813..936818) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936820..936839 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 936828 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" CDS 936861..937553 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" gene 936861..937553 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" promotor_-35 937582..937586 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(937585..937604) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937597) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 937600..937619 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(937619..937626) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 937623..937730 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 937623..937730 /gene="tswD" /locus_tag="BSU_misc_RNA_11" upshifts 937630 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" downshifts 937761 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" CDS 937863..939635 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" gene 937863..939635 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" downshifts 939611 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" S_feature 939656..940581 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(939673..941028) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" gene complement(939673..941028) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" promotor_-10 complement(941056..941075) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(941073) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" promotor_-35 complement(941089..941098) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 941146..941152 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 941167..941186 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 941195 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" CDS 941279..941476 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" gene 941279..941476 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" CDS complement(941503..942954) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" gene complement(941503..942954) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" downshifts complement(941513) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" promotor_-35 942931..942937 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942952..942971 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 942955 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" promotor_-10 complement(942972..942991) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942977..943306 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(942991) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" promotor_-35 complement(943005..943012) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(943050..943068) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(943075) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" downshifts 943263 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" CDS 943362..944129 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" gene 943362..944129 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" CDS 944147..945145 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" gene 944147..945145 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" CDS 945142..945972 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" gene 945142..945972 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" CDS 945995..947125 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" gene 945995..947125 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" misc_feature 947152..947171 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 947158 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" CDS 947229..947765 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" gene 947229..947765 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" S_feature 947766..947836 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 947806..947813 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947827..947846 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947838 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" CDS 947877..948146 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" gene 947877..948146 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" promotor_-35 947949..947953 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947976..947992 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947992 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 948133 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" CDS complement(948164..948637) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" gene complement(948164..948637) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" downshifts complement(948200) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" CDS complement(948639..948839) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" gene complement(948639..948839) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" promotor_-10 complement(948868..948887) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(948882) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" promotor_-35 complement(948900..948907) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 948963..948968 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 948982..949001 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 948982 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" tRNA 949033..949106 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 949033..949106 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" S_feature 949107..949289 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(949197..949820) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" gene complement(949197..949820) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" downshifts complement(949212) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" downshifts 949246 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" S_feature 949291..949902 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(949844..949863) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(949865) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" promotor_-35 complement(949877..949884) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 949903..951063 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" gene 949903..951063 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" downshifts 951072 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" misc_feature 951089..951101 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 951094 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" CDS 951130..952065 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" gene 951130..952065 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" downshifts complement(951148) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" promotor_-35 952049..952052 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 952067 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" promotor_-10 952068..952087 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 952103..952585 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" gene 952103..952585 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" downshifts 952568 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" CDS 952635..953351 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" gene 952635..953351 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" promotor_-35 952655..952662 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 952677..952696 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 952678 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" CDS 953342..954055 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" gene 953342..954055 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" CDS 954067..954774 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" gene 954067..954774 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" downshifts 954658 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" downshifts 954702 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" downshifts 954768 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" S_feature complement(954801..954976) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(954844) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" promotor_-10 complement(954968..954987) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954976) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" promotor_-35 complement(955002..955009) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955041..955046 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955062..955080 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955062 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" CDS 955124..957019 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" gene 955124..957019 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" promotor_no_box 955566..955666 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 955626 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 955692 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" downshifts 957012 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" promotor_-35 957076..957081 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957097..957115 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 957100..957198 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 957100 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" CDS 957199..958377 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" gene 957199..958377 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" promotor_-35 957397..957400 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957415..957434 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957419 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(957660) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" downshifts 958356 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" promotor_-35 958464..958471 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958486..958505 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958486 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 958537..959001 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" gene 958537..959001 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" promotor_-35 958826..958832 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958847..958865 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958860 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" promotor_-35 959010..959016 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959030..959041 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959036 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" CDS 959037..959702 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" gene 959037..959702 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" CDS 959743..961341 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" gene 959743..961341 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" CDS 961364..961894 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" gene 961364..961894 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" CDS 961907..962281 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" gene 961907..962281 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" downshifts 962270 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" CDS 962281..962436 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" gene 962281..962436 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" promotor_-35 962371..962377 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 962392..962411 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 962402 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" CDS 962441..963202 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" gene 962441..963202 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" promotor_-10 complement(962754..962772) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962768) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(962788..962793) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 963205..963570 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" gene 963205..963570 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" CDS 963572..964270 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" gene 963572..964270 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" CDS 964287..965204 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" gene 964287..965204 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" CDS 965197..966138 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" gene 965197..966138 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" downshifts 966120 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" CDS complement(966230..966433) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" gene complement(966230..966433) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" downshifts complement(966244) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" S_feature complement(966434..966561) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 966521..966532 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 966538 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(966550..966569) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966561) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" S_feature complement(966563..967701) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(966583..966588) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 966728..966735 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966750..966768 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966757 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" S_feature 966758..966868 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 966869..967699 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" gene 966869..967699 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" downshifts 967658 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" CDS complement(967702..968781) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" gene complement(967702..968781) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" promotor_-10 complement(968791..968810) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(968812) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" promotor_-35 complement(968826..968830) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 968888..968895 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968909..968928 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968915 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" CDS 968954..970345 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" gene 968954..970345 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" S_feature complement(969981..970384) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 970324 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" CDS complement(970385..970840) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" gene complement(970385..970840) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" promotor_-10 complement(970855..970873) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970883) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" promotor_-35 complement(970888..970894) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 970932..970938 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970952..970963 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970956 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" CDS 970990..971559 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" gene 970990..971559 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" promotor_-35 971186..971192 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 971203 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 971206..971217 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 971534 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" promotor_-35 971602..971611 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971625..971644 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971635 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" CDS 971680..972648 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" gene 971680..972648 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" downshifts 972524 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" CDS complement(972580..973233) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " gene complement(972580..973233) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" downshifts complement(972597) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(973264..973275) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973266) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" promotor_-35 complement(973290..973296) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973305..973313 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 973316..976969 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" gene 973316..976969 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" promotor_-10 973324..973342 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973339 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" CDS 976966..977562 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" gene 976966..977562 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" downshifts 977541 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" CDS complement(977592..978500) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" gene complement(977592..978500) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" promotor_-35 978556..978564 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(978557..978568) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(978563) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" S_feature complement(978565..979051) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 978575 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" promotor_-10 978578..978597 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(978582..978588) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 978611..979006 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" gene 978611..979006 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" misc_feature complement(979037..979056) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(979051) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" promotor_-35 979091..979097 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979106 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" promotor_-10 979111..979122 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(979121..979135) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979135) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(979143..979147) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 979143..979565 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" gene 979143..979565 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" promotor_no_box complement(979469..979569) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(979509) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 979543 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" downshifts complement(979575) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" promotor_-35 979615..979622 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979636..979655 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979644 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" CDS 979692..980354 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" gene 979692..980354 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" CDS 980370..981911 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" gene 980370..981911 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" downshifts 981894 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" CDS 981995..982186 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" gene 981995..982186 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo promotor_-35 982217..982224 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 982239..982258 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 982250..982331 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 982250 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" CDS 982332..983684 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" gene 982332..983684 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" CDS 983712..984290 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" gene 983712..984290 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" promotor_-35 984285..984292 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984307..984326 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984318 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" downshifts 984333 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" S_feature 984378..984468 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 984469..985293 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" gene 984469..985293 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" CDS 985312..986802 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" gene 985312..986802 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" promotor_-35 986113..986119 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 986134..986153 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 986144 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" S_feature 986803..986891 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 986848 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" promotor_no_box 986854..986954 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 986914 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" CDS 986943..988610 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" gene 986943..988610 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" promotor_-35 988372..988377 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 988392..988410 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 988401 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" promotor_-35 988455..988461 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988476 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 988477..988495 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 988578 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" S_feature 988623..988696 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 988678..988685 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988698 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" promotor_-10 988699..988718 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988742..990487 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" gene 988742..990487 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" downshifts 990476 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" S_feature 990521..990590 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 990592..990611 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 990592 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" CDS 990636..991775 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" gene 990636..991775 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" CDS 991772..992416 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" gene 991772..992416 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" CDS 992413..992937 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" gene 992413..992937 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" downshifts 992902 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" CDS complement(992952..993194) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" gene complement(992952..993194) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" downshifts complement(992973) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" promotor_-10 complement(993230..993241) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(993241) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" promotor_-35 complement(993255..993262) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 993329..993335 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993349..993360 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993359 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" CDS 993395..993718 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" gene 993395..993718 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" S_feature 993719..995585 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(993760..995226) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" gene complement(993760..995226) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" downshifts complement(993772) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" downshifts complement(993859) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(995266..995284) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995278) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" promotor_-35 complement(995298..995305) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(995379..995819) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" gene complement(995379..995819) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" downshifts complement(995409) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" promotor_-35 995807..995813 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995827..995838 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 995829..995939 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 995829 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" promotor_-10 complement(995841..995860) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995857) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" promotor_-35 complement(995872..995878) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 995898 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" CDS complement(995926..997584) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" gene complement(995926..997584) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" downshifts complement(995931) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" promotor_-10 complement(997475..997493) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997495) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" promotor_-35 complement(997507..997513) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 997556..997561 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997577..997595 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997590 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" CDS 997615..999021 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" gene 997615..999021 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" downshifts 999001 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" CDS complement(999051..1000436) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" gene complement(999051..1000436) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" downshifts complement(999077) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" upshifts complement(1000463) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" S_feature complement(1000465..1001996) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(1000473..1000484) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1000592..1000599 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000612..1000631 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1000618..1000905 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 1000618 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" promotor_-35 1000868..1000871 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000886..1000905 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1000907 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" CDS 1000966..1001970 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" gene 1000966..1001970 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" downshifts 1001832 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" downshifts 1001962 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" upshifts complement(1001996) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" promotor_-10 complement(1002003..1002018) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1002008 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" promotor_-35 complement(1002030..1002039) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1002041..1002916) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" gene complement(1002041..1002916) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" promotor_-35 1002969..1002970 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1002982..1003001) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 1002987..1003006 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002988) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" upshifts 1002997 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" promotor_-35 complement(1003016..1003021) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 1003025..1004125 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" gene 1003025..1004125 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" promotor_-35 1004136..1004142 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1004157..1004175 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1004162 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" CDS 1004199..1005068 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" gene 1004199..1005068 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" downshifts 1005076 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" promotor_-35 1005153..1005156 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005168 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" promotor_-10 1005171..1005190 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 1005216..1005235 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1005221..1005317 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 1005221 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" CDS 1005318..1006715 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" gene 1005318..1006715 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" downshifts 1006695 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" promotor_-35 1006776..1006780 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006796..1006815 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006803 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" CDS 1006833..1008188 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" gene 1006833..1008188 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" downshifts 1008169 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" CDS complement(1008223..1009632) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" gene complement(1008223..1009632) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" promotor_-35 1009681..1009684 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1009699..1009718 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1009701 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" promotor_-10 complement(1009703..1009722) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009715) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" promotor_-35 complement(1009738..1009742) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1009742..1010170 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" gene 1009742..1010170 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" downshifts 1010149 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" CDS complement(1010201..1010491) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" gene complement(1010201..1010491) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" downshifts complement(1010225) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" CDS complement(1010479..1011555) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" gene complement(1010479..1011555) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" CDS complement(1011545..1012036) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" gene complement(1011545..1012036) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" S_feature complement(1012037..1012139) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(1012128..1012147) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012139) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" promotor_-35 complement(1012161..1012164) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012177..1012183 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1012194 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" promotor_-10 1012198..1012216 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1012227) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" CDS 1012233..1013228 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" gene 1012233..1013228 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" downshifts 1013207 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1013290..1013293 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013308..1013327 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013313 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" CDS 1013363..1013962 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" gene 1013363..1013962 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" downshifts 1013977 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" S_feature 1014022..1015976 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(1014031..1015365) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" gene complement(1014031..1015365) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" downshifts complement(1014050) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" CDS complement(1015426..1015857) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" gene complement(1015426..1015857) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" promotor_-10 complement(1015869..1015888) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015879) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" promotor_-35 complement(1015903..1015909) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(1015905..1016005) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 1015940..1015947 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(1015945) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1015961..1015980 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 1015978 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" CDS 1016014..1017195 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" gene 1016014..1017195 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" downshifts 1017180 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" S_feature 1017225..1017363 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 1017359..1017378 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1017365..1017521 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 1017365 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" CDS 1017522..1018907 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" gene 1017522..1018907 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" downshifts 1018797 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" downshifts 1018883 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" CDS complement(1018921..1019277) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" gene complement(1018921..1019277) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" CDS complement(1019274..1019669) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" gene complement(1019274..1019669) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" CDS complement(1019656..1020387) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" gene complement(1019656..1020387) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" misc_feature complement(1020412..1020431) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1020433) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" promotor_-35 1020480..1020488 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020497 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" promotor_-10 1020502..1020517 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1020511..1020584 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 1020571..1020572 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020586 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" promotor_-10 1020588..1020607 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1020621..1020728 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" gene 1020621..1020728 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" S_feature 1020729..1020782 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 1020753 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" misc_feature 1020833..1020852 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1020839 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" CDS 1020877..1021992 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" gene 1020877..1021992 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" downshifts 1021972 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" misc_feature 1022029..1022048 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1022029 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" CDS 1022062..1022805 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" gene 1022062..1022805 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" downshifts 1022777 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" CDS complement(1022829..1023677) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" gene complement(1022829..1023677) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" downshifts complement(1022853) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" promotor_-35 1023673..1023678 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1023678..1023777) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 1023694..1023712 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023696 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" S_feature 1023701..1023896 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(1023766..1023785) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023780) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" promotor_-35 complement(1023800..1023803) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1023895..1023914 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1023898..1023961 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 1023898 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" CDS 1023962..1024810 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" gene 1023962..1024810 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" downshifts 1024801 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" CDS complement(1024853..1026214) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" gene complement(1024853..1026214) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" downshifts complement(1024877) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" S_feature complement(1026215..1026285) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(1026258..1026277) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1026285) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" CDS complement(1026341..1026841) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" gene complement(1026341..1026841) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" downshifts complement(1026373) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(1026863..1026881) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026883) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" promotor_-35 complement(1026896..1026902) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026920..1026927 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1026935..1027004 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 1026936 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" promotor_-10 1026942..1026961 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027005..1027166 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" gene 1027005..1027166 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" downshifts 1027096 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" S_feature 1027167..1027285 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 1027286..1029043 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" gene 1027286..1029043 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" CDS 1029040..1031061 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" gene 1029040..1031061 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" downshifts 1031049 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" CDS complement(1031110..1031730) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" gene complement(1031110..1031730) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" downshifts complement(1031125) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" promotor_no_box 1031715..1031815 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1031744..1031763) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031759) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" CDS complement(1031769..1031894) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" gene complement(1031769..1031894) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" upshifts 1031775 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1031778..1031781) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1031908..1031927) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1031917) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" promotor_-35 complement(1031941..1031950) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1031973 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" CDS complement(1031999..1032202) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" gene complement(1031999..1032202) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" downshifts complement(1032004) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" S_feature complement(1032203..1032313) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 1032243..1032343 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1032303 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1032319) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" promotor_-10 complement(1032323..1032334) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1032349..1032355) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032411..1032629) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" gene complement(1032411..1032629) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" downshifts complement(1032445) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(1032670..1032689) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032687) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" promotor_-35 complement(1032703..1032710) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032779..1034140) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" gene complement(1032779..1034140) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" downshifts complement(1032797) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" downshifts complement(1032841) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" CDS complement(1034130..1035221) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" gene complement(1034130..1035221) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" promotor_-10 complement(1034545..1034559) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1034557) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1034573..1034581) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1035222..1035327) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1035311..1035329) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1035331) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" promotor_-35 complement(1035345..1035350) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035393..1035400 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035415..1035434 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035426 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" CDS 1035488..1036621 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" gene 1035488..1036621 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" S_feature 1036622..1036713 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1036714..1037067 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" gene 1036714..1037067 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" downshifts 1037055 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" CDS complement(1037111..1038184) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" gene complement(1037111..1038184) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" downshifts complement(1037218) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" promotor_-10 complement(1038206..1038225) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038218) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" promotor_-35 complement(1038239..1038246) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1038321..1038328 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1038341 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" promotor_-10 1038343..1038362 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1038352..1038505 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1038462 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" S_feature 1038507..1038590 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1038547 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" promotor_-35 1038603..1038608 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1038624..1038642 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1038633 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" CDS 1038670..1039536 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" gene 1038670..1039536 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" downshifts 1039518 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" promotor_-35 1039581..1039584 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039599..1039618 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039607 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" CDS 1039648..1041153 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" gene 1039648..1041153 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" downshifts 1041123 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" CDS complement(1041171..1042388) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" gene complement(1041171..1042388) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" downshifts complement(1041177) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" CDS complement(1042395..1042892) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" gene complement(1042395..1042892) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" CDS complement(1042956..1043294) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" gene complement(1042956..1043294) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" promotor_-10 complement(1043306..1043325) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043330) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" promotor_-35 complement(1043339..1043346) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043366..1043373 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043388..1043407 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043398 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" CDS 1043459..1044226 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" gene 1043459..1044226 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" downshifts 1044227 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" CDS complement(1044247..1044432) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" gene complement(1044247..1044432) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" promotor_-10 complement(1044468..1044486) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044479) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" promotor_-35 complement(1044497..1044505) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044506..1044509 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044524..1044543 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044534 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" CDS 1044559..1045455 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" gene 1044559..1045455 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" CDS 1045448..1046707 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" gene 1045448..1046707 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" downshifts 1046691 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" promotor_-35 1046755..1046762 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046774..1046793 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1046779 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" CDS 1046814..1048040 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" gene 1046814..1048040 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" downshifts complement(1047515) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" CDS 1048045..1050936 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" gene 1048045..1050936 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" promotor_-35 1049326..1049331 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049347..1049365 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049353 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" promotor_-35 1050944..1050949 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050964..1050983 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050979 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" CDS 1051010..1051954 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" gene 1051010..1051954 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" downshifts 1051932 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" promotor_-35 1052013..1052018 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1052034..1052052 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1052037 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" CDS 1052079..1052291 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" gene 1052079..1052291 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" downshifts 1052284 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" downshifts complement(1052322) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" CDS complement(1052332..1053210) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" gene complement(1052332..1053210) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" downshifts complement(1052520) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" promotor_-10 complement(1053248..1053267) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053272) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" promotor_-35 complement(1053281..1053288) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1053308..1053317 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1053329 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" promotor_-10 1053330..1053349 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1053366..1053380) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053367) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1053370..1053456 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" gene 1053370..1053456 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" promotor_-35 complement(1053389..1053393) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1053457..1053708 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1053581..1053667 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" gene 1053581..1053667 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" downshifts 1053665 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" S_feature complement(1053677..1053939) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1053710..1054193 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1053720) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1053932..1053951) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053939) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" S_feature complement(1053941..1054009) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1053965..1053970) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1054010..1054528) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" gene complement(1054010..1054528) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" promotor_-35 1054315..1054323 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054335..1054353 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054348 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1054559..1054578) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054577) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" promotor_-35 complement(1054594..1054600) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1054677..1054680 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1054695..1054714 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1054700 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" CDS 1054736..1055077 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" gene 1054736..1055077 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" S_feature complement(1054931..1055073) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1054974) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" CDS complement(1055074..1055685) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" gene complement(1055074..1055685) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" S_feature 1055078..1055843 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1055150) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" promotor_-35 1055681..1055685 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055693..1055706 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055705 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1055710..1055729) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1055733) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" promotor_-35 complement(1055744..1055747) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1055800 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" CDS complement(1055863..1056219) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" gene complement(1055863..1056219) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" downshifts complement(1055867) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" promotor_-35 1056296..1056301 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1056302..1056321) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1056316) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" promotor_-10 1056317..1056335 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056317 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" S_feature complement(1056318..1056581) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1056349..1056540 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" gene 1056349..1056540 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" S_feature 1056541..1057976 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1056614..1057132) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" gene complement(1056614..1057132) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" downshifts complement(1056626) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" S_feature complement(1057133..1057220) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1057212..1057231) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057220) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" promotor_-35 complement(1057245..1057252) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1057257..1058336) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" gene complement(1057257..1058336) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" misc_feature complement(1058375..1058394) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1058386) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" S_feature complement(1058388..1058469) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1058483..1058920) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" gene complement(1058483..1058920) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" downshifts complement(1058514) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(1058953..1058972) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058967) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" downshifts 1058970 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" promotor_-35 complement(1058986..1058993) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1058992..1059288) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1059035) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" promotor_-10 complement(1059286..1059297) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059292) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" promotor_-35 complement(1059312..1059318) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059348..1059355 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059369..1059388 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059378 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" CDS 1059408..1060151 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" gene 1059408..1060151 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" CDS 1060144..1061370 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" gene 1060144..1061370 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" promotor_-10 complement(1060703..1060721) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060718) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1060737..1060742) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1061390..1062100 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" gene 1061390..1062100 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" downshifts 1062064 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" CDS complement(1062118..1063308) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" gene complement(1062118..1063308) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" downshifts complement(1062128) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1062193) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" promotor_-10 complement(1063332..1063351) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063353) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1063365..1063370) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063381..1064772) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" gene complement(1063381..1064772) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" promotor_-10 complement(1064783..1064802) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064788) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" promotor_-35 complement(1064815..1064824) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1064838..1065152) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" gene complement(1064838..1065152) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" CDS complement(1065197..1065697) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" gene complement(1065197..1065697) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" downshifts complement(1065224) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" promotor_-10 complement(1065710..1065729) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1065712..1065716 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1065731) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" promotor_-10 1065732..1065751 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065733 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" promotor_-35 complement(1065746..1065747) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1065764..1065770 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065785..1065796 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065790 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" CDS 1065819..1067963 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" gene 1065819..1067963 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" promotor_-10 complement(1065863..1065874) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065866) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1065888..1065894) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068000..1068006 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068020..1068039 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068030 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" CDS 1068085..1069146 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" gene 1068085..1069146 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" CDS 1069218..1070150 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" gene 1069218..1070150 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" CDS 1070165..1071577 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" gene 1070165..1071577 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" downshifts 1070168 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" downshifts 1071554 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" promotor_-35 1071638..1071645 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071659..1071678 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071664 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" CDS 1071723..1072298 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" gene 1071723..1072298 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" promotor_-35 1072042..1072045 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1072060 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" promotor_-10 1072062..1072081 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072299..1072368 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1072369..1074696 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" gene 1072369..1074696 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" downshifts 1074678 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" CDS complement(1074738..1075715) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" gene complement(1074738..1075715) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" downshifts complement(1074751) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" promotor_-10 complement(1075729..1075748) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1075747) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" promotor_-35 complement(1075762..1075768) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1075774..1075782 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075793..1075811 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1075800 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" CDS 1075842..1076618 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" gene 1075842..1076618 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" S_feature complement(1076334..1076955) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1076619..1076990 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1076933..1076952) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1076954) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" promotor_-35 complement(1076966..1076975) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1076968..1076975 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1076990..1077009 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1076992 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" CDS 1077031..1078071 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" gene 1077031..1078071 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" CDS 1078084..1078491 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" gene 1078084..1078491 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" downshifts 1078462 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" CDS complement(1078528..1079817) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" gene complement(1078528..1079817) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" downshifts complement(1078558) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" S_feature complement(1079818..1079918) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1079917..1079936) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079918) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" S_feature complement(1079920..1080056) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1079951..1079957) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1080088..1080228) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" gene complement(1080088..1080228) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" downshifts complement(1080101) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" promotor_-10 complement(1080247..1080266) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1080266) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" promotor_-35 complement(1080279..1080286) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1080310..1080316 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1080330..1080349 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080333 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" CDS 1080380..1081114 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" gene 1080380..1081114 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" CDS 1081127..1082122 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" gene 1081127..1082122 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" CDS 1082187..1082831 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" gene 1082187..1082831 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" downshifts 1082819 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" promotor_-35 1082859..1082862 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1082877..1082896 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1082884 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" CDS 1082948..1084489 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" gene 1082948..1084489 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" downshifts 1084469 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" CDS complement(1084528..1084923) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" gene complement(1084528..1084923) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" downshifts complement(1084545) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1084943..1084954) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1084947) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" promotor_-35 complement(1084969..1084975) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085008..1085011 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1085019 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" promotor_-10 1085026..1085045 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1085072..1086352 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" gene 1085072..1086352 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" promotor_-10 complement(1085499..1085518) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085513) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1085534..1085539) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1086339 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" downshifts complement(1086389) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" CDS complement(1086391..1087536) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" gene complement(1086391..1087536) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" S_feature complement(1087537..1087603) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1087592..1087611) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087609) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" promotor_-35 complement(1087627..1087631) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087916..1087923 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1087938..1087957 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1087940 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" CDS 1087971..1088420 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" gene 1087971..1088420 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" promotor_-35 1088436..1088443 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088458..1088477 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088465 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" CDS 1088492..1089484 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" gene 1088492..1089484 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" downshifts 1089485 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" S_feature 1089530..1089640 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1089618..1089625 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1089641..1089660 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1089642 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" CDS 1089701..1090672 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" gene 1089701..1090672 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" downshifts 1090651 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" CDS complement(1090704..1091285) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" gene complement(1090704..1091285) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" downshifts complement(1090727) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1091309..1091328) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091321) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" promotor_-35 complement(1091344..1091347) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1091356..1092450) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" gene complement(1091356..1092450) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" CDS complement(1092447..1093886) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" gene complement(1092447..1093886) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" CDS complement(1093893..1094453) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" gene complement(1093893..1094453) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" misc_feature complement(1093903..1093922) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1093917) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-10 complement(1094478..1094497) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1094492) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" promotor_-35 complement(1094512..1094519) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1094588..1095886) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" gene complement(1094588..1095886) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" downshifts complement(1094599) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1095940..1095958) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095943) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" promotor_-35 complement(1095972..1095978) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1096025..1097554) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" gene complement(1096025..1097554) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" promotor_-10 complement(1097581..1097599) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097591) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" promotor_-35 1097610..1097615 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1097614..1097619) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1097627 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" promotor_-10 1097631..1097649 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1097666..1098523 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" gene 1097666..1098523 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" downshifts 1098505 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" CDS complement(1098551..1098784) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" gene complement(1098551..1098784) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" downshifts complement(1098584) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(1098801..1098820) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1098804..1098805 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1098804 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" promotor_-10 1098808..1098823 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1098823) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" S_feature complement(1098825..1099680) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1098835..1098842) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1099007..1099014 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1099026..1099045 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1099032 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" CDS 1099077..1099655 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" gene 1099077..1099655 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" S_feature 1099656..1099801 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1099702..1100601) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" gene complement(1099702..1100601) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" downshifts complement(1099725) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 1099788..1099791 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1099803 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1099809..1099813 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1099847 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" S_feature 1099892..1100758 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1100628..1100646) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100645) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" promotor_-35 complement(1100661..1100667) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1100735..1100742 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100757..1100776 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100760 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" CDS 1100818..1101087 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" gene 1100818..1101087 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" downshifts 1101079 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" downshifts complement(1101127) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" CDS complement(1101130..1102599) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" gene complement(1101130..1102599) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" CDS complement(1102596..1102796) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" gene complement(1102596..1102796) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" S_feature complement(1102797..1102915) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1102898..1102917) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102915) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" promotor_-35 complement(1102930..1102937) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1103003) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" CDS complement(1103004..1103366) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" gene complement(1103004..1103366) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" promotor_-35 1103204..1103209 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1103225..1103243 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1103226 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" S_feature 1103235..1103474 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1103396..1103415) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103414) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" promotor_-35 complement(1103430..1103437) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1103456..1103463 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1103476 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" promotor_-10 1103477..1103496 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1103518..1104141 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" gene 1103518..1104141 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" CDS 1104143..1104649 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" gene 1104143..1104649 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" downshifts 1104642 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" promotor_-35 1104700..1104707 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1104721..1104740 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1104730..1104829 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1104730 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" CDS 1104830..1106329 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" gene 1104830..1106329 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" promotor_-35 1106337..1106344 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106356 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" promotor_-10 1106358..1106377 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1106406..1106933 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" gene 1106406..1106933 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" downshifts 1106895 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" S_feature complement(1106947..1107090) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1106985) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" CDS complement(1107091..1108296) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" gene complement(1107091..1108296) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" promotor_-35 1107786..1107791 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1107808..1107826 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1107811..1108337 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1107812 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" downshifts 1108295 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" CDS complement(1108368..1109420) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" gene complement(1108368..1109420) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" CDS complement(1109434..1110282) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" gene complement(1109434..1110282) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" CDS complement(1110254..1111579) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" gene complement(1110254..1111579) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" promotor_-35 1110423..1110428 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1110444..1110462 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1110450..1111238 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1110450 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" promotor_-35 1111214..1111221 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111236..1111255 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1111240..1111682 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1111240 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" promotor_-10 complement(1111614..1111633) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1111626) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" promotor_-35 complement(1111647..1111654) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1111683..1112672 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" gene 1111683..1112672 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" S_feature 1112673..1113050 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1112727..1112885) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1112770) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" CDS complement(1112886..1114040) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" gene complement(1112886..1114040) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" S_feature complement(1114041..1114112) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1114095..1114114) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114111) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" promotor_-35 complement(1114128..1114133) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1114147..1115352) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" gene complement(1114147..1115352) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" misc_feature 1115373..1115392 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1115378 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1115466..1117193 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" gene 1115466..1117193 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" promotor_-35 1116779..1116786 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116801..1116820 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116808 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1117223..1117549) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" gene complement(1117223..1117549) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" CDS complement(1117667..1118104) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" gene complement(1117667..1118104) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" downshifts complement(1117676) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" promotor_-10 complement(1118135..1118154) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118155) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" promotor_-35 complement(1118167..1118176) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1118224..1118231 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118245..1118264 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118257 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" CDS 1118288..1121788 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" gene 1118288..1121788 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" CDS 1121775..1125473 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" gene 1121775..1125473 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" S_feature 1125474..1125544 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1125545..1126720 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " gene 1125545..1126720 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" CDS 1126717..1130109 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" gene 1126717..1130109 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" promotor_-35 1129364..1129370 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129385..1129396 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1129392 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" S_feature complement(1129461..1130434) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1130123..1130425 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" gene 1130123..1130425 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" downshifts 1130405 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" CDS complement(1130462..1130680) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" gene complement(1130462..1130680) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" downshifts complement(1130479) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" CDS complement(1130712..1131113) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" gene complement(1130712..1131113) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" CDS complement(1131113..1131289) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" gene complement(1131113..1131289) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" CDS complement(1131286..1131903) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" gene complement(1131286..1131903) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" CDS complement(1131926..1132159) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" gene complement(1131926..1132159) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" CDS complement(1132174..1132395) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" gene complement(1132174..1132395) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" S_feature complement(1132396..1132482) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1132410..1132416 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1132430..1132449 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1132432..1133087 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1132432 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" promotor_-10 complement(1132469..1132488) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132482) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" S_feature complement(1132484..1132613) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1132501..1132510) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1132615..1132817) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1132658) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" CDS complement(1132818..1132988) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" gene complement(1132818..1132988) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" misc_feature complement(1133032..1133051) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133035) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" S_feature complement(1133037..1133133) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1133044 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" S_feature 1133089..1133253 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1133134..1134057) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" gene complement(1133134..1134057) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" promotor_-10 complement(1134079..1134098) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1134090) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" promotor_-35 complement(1134112..1134121) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1134141..1134149 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1134161..1134179 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1134166 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" CDS 1134212..1135117 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" gene 1134212..1135117 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" S_feature 1135118..1135198 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1135168..1135171 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135188..1135207 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135200 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" CDS 1135233..1135589 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" gene 1135233..1135589 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" downshifts 1135486 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" downshifts 1135577 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" upshifts 1135710 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" misc_feature 1135713..1135732 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1135757..1138441 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" gene 1135757..1138441 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" downshifts complement(1135925) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" downshifts 1138433 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" CDS complement(1138472..1139059) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" gene complement(1138472..1139059) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" promotor_-10 complement(1139074..1139093) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139093) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" promotor_-35 complement(1139109..1139111) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139114..1139120 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1139132 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" promotor_-10 1139135..1139153 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1139138..1139204 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1139205..1141049 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" gene 1139205..1141049 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" S_feature 1141050..1141117 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1141074 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" CDS complement(1141179..1141658) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " gene complement(1141179..1141658) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" upshifts complement(1141678) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" promotor_-10 complement(1141682..1141700) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1141711..1141719) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1141850..1141854 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141867 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" promotor_-10 1141869..1141888 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141890..1142714 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" gene 1141890..1142714 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" promotor_-35 1142102..1142108 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142123..1142141 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142130 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1142724..1144174 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1142744..1144111) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" gene complement(1142744..1144111) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" promotor_-35 1144143..1144150 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1144164..1144183 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1144176 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" CDS 1144235..1145098 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" gene 1144235..1145098 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" CDS 1145116..1146129 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" gene 1145116..1146129 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" downshifts 1146112 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" promotor_-35 1146181..1146188 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1146203..1146222 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1146222..1146337 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1146222 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" CDS 1146338..1147366 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" gene 1146338..1147366 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" downshifts 1147388 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" CDS complement(1147417..1147926) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" gene complement(1147417..1147926) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" downshifts complement(1147436) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" promotor_-10 complement(1147939..1147957) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147955) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" promotor_-35 complement(1147969..1147977) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1147976..1148638) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" gene complement(1147976..1148638) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" promotor_-35 1148657..1148663 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148677..1148696 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1148686 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" CDS 1148705..1150159 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" gene 1148705..1150159 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" S_feature complement(1150014..1150166) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1150049) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" CDS complement(1150167..1150805) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" gene complement(1150167..1150805) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" S_feature complement(1150806..1150940) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1150854..1150859 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150875..1150893 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1150876 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" S_feature 1150886..1151010 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1150926..1150945) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150940) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" promotor_-35 complement(1150960..1150967) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1151011..1151817 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" gene 1151011..1151817 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" downshifts 1151810 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" CDS complement(1151845..1152444) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" gene complement(1151845..1152444) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" downshifts complement(1151864) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" CDS complement(1152441..1153610) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" gene complement(1152441..1153610) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" S_feature complement(1153611..1153722) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1153723..1154433) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" gene complement(1153723..1154433) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" promotor_-10 complement(1154477..1154496) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154499) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" promotor_-35 complement(1154509..1154518) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154548..1154557 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154571..1154590 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154582 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" CDS 1154618..1155304 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" gene 1154618..1155304 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" CDS 1155301..1156059 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" gene 1155301..1156059 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" downshifts 1156056 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" CDS complement(1156104..1156733) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" gene complement(1156104..1156733) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" promotor_-10 complement(1156767..1156785) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1156784) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" promotor_-35 complement(1156800..1156805) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1156829..1157944) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" gene complement(1156829..1157944) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" downshifts complement(1156858) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" CDS complement(1157953..1159221) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" gene complement(1157953..1159221) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" promotor_-10 complement(1159247..1159258) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159256) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" promotor_-35 complement(1159272..1159278) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1159333..1160181) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" gene complement(1159333..1160181) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" downshifts complement(1159344) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" CDS complement(1160186..1160635) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" gene complement(1160186..1160635) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" promotor_-10 complement(1160656..1160675) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160670) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" promotor_-35 complement(1160691..1160692) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1160725..1162563) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" gene complement(1160725..1162563) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" downshifts complement(1160752) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" downshifts complement(1162645) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" misc_RNA complement(1162653..1162770) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1162653..1162770) /gene="mswK" /locus_tag="BSU_misc_RNA_12" promotor_-10 complement(1162822..1162841) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1162836) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1162856..1162863) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1162877..1163368) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" gene complement(1162877..1163368) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" promotor_-35 1163386..1163389 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1163392..1163411) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1163404..1163423 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163405 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" upshifts complement(1163410) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" promotor_-35 complement(1163426..1163433) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1163467..1164363 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" gene 1163467..1164363 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" downshifts 1164350 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" CDS complement(1164416..1165000) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" gene complement(1164416..1165000) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" downshifts complement(1164426) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" CDS complement(1164997..1165926) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" gene complement(1164997..1165926) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" misc_feature complement(1165082) /Source="Nicolas_upshift_promotors" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1165084) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" CDS complement(1165911..1166447) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" gene complement(1165911..1166447) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" promotor_-10 complement(1166483..1166502) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166497) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" promotor_-35 complement(1166517..1166520) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1166588..1166595 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166610..1166629 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166613 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" CDS 1166625..1166972 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" gene 1166625..1166972 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" CDS 1166969..1167556 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" gene 1166969..1167556 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" CDS 1167576..1167869 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" gene 1167576..1167869 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" downshifts 1167849 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" downshifts 1167893 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" CDS 1168005..1169621 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" gene 1168005..1169621 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" downshifts 1169609 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" CDS complement(1169668..1170519) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" gene complement(1169668..1170519) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" downshifts complement(1169685) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" promotor_-35 1170066..1170073 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170088..1170107 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1170093..1170618 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1170095 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" promotor_-10 complement(1170560..1170579) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170583) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" promotor_-35 1170597..1170602 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1170599) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170617..1170635 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170620 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" CDS 1170657..1171499 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" gene 1170657..1171499 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" promotor_-35 1171152..1171160 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171171..1171189 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171171 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" S_feature 1171500..1171613 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1171614..1171973 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" gene 1171614..1171973 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" downshifts 1171962 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" CDS complement(1172004..1172201) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" gene complement(1172004..1172201) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" downshifts complement(1172017) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" S_feature complement(1172202..1172398) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1172398) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" promotor_-10 complement(1172400..1172411) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1172426..1172432) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1172458..1173270) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" gene complement(1172458..1173270) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" promotor_-10 complement(1173308..1173327) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1173328..1173335 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1173328) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" promotor_-35 complement(1173341..1173348) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1173347..1173366 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1173349 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" CDS 1173391..1174158 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" gene 1173391..1174158 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" promotor_-35 1174167..1174173 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1174187 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" promotor_-10 1174188..1174207 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1174222..1174530 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" gene 1174222..1174530 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" downshifts 1174515 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" S_feature 1174560..1174825 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1174826..1176256 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" gene 1174826..1176256 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" CDS 1176301..1176795 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" gene 1176301..1176795 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" downshifts 1176759 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" promotor_-35 1176933..1176940 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1176939 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" promotor_-10 1176954..1176973 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1177002..1178039 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" gene 1177002..1178039 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" CDS 1178059..1179279 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" gene 1178059..1179279 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" CDS 1179294..1180070 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" gene 1179294..1180070 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" CDS 1180067..1181224 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" gene 1180067..1181224 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" CDS 1181295..1182356 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQ PYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMT SQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEW IFDDYLKNVIPARREIAHA*" gene 1181295..1182356 /gene="carA" /locus_tag="BSU_11230" /old_locus_tag="BSU11230" misc_feature complement(1182190..1182209) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1182200) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1182349..1185441 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" gene 1182349..1185441 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" CDS 1185429..1186388 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" gene 1185429..1186388 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" downshifts 1186351 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" S_feature complement(1186391..1186665) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1186416..1186422 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1186424) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" promotor_-10 1186437..1186448 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186458 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" CDS 1186474..1186653 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" gene 1186474..1186653 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" downshifts 1186663 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" CDS complement(1186699..1186884) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" gene complement(1186699..1186884) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" downshifts complement(1186710) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" promotor_-10 complement(1186913..1186932) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1186930) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" promotor_-35 complement(1186943..1186950) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1186985..1186991 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1187003..1187022 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1187008 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1187065..1187074 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1187074 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" promotor_-10 1187087..1187106 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1187133..1187867 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" gene 1187133..1187867 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" S_feature complement(1187626..1188228) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1187848..1187853 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1187866 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" upshifts 1187866 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" promotor_-10 1187869..1187887 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1187949..1188506 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" gene 1187949..1188506 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" promotor_-10 complement(1188208..1188227) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1188228) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" promotor_-35 complement(1188242..1188246) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1188513..1188520 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1188535..1188554 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1188547 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" CDS 1188597..1189550 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" gene 1188597..1189550 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" promotor_-35 1189214..1189218 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1189234..1189253 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1189247 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" CDS 1189565..1189756 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" gene 1189565..1189756 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" downshifts 1189735 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" S_feature 1189780..1190120 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1189786..1190025) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" gene complement(1189786..1190025) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" downshifts complement(1189802) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" promotor_-10 complement(1190038..1190057) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1190059) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" promotor_-35 complement(1190071..1190080) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1190086..1190093 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1190108..1190127 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1190122 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" CDS 1190190..1191128 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" gene 1190190..1191128 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" promotor_-35 1190267..1190276 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1190285 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" promotor_-10 1190288..1190303 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1191151..1192392 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" gene 1191151..1192392 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" promotor_-10 complement(1191365..1191383) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191373) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1191399..1191404) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1192243 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" downshifts 1192376 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" promotor_-35 1192417..1192426 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1192439..1192458 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1192441 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" promotor_-35 1192453..1192461 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1192468..1193253 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" gene 1192468..1193253 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" promotor_-10 1192473..1192491 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1192485 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1193254..1193338 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1193270..1193288) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193287) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1193303..1193308) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1193306..1193313 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193328..1193347 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1193340..1193444 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1193340 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1193445..1194431 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" gene 1193445..1194431 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" CDS 1194428..1195417 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" gene 1194428..1195417 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" misc_feature 1195423..1195429 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1195428..1195504 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1195428 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" CDS 1195505..1195996 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" gene 1195505..1195996 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo CDS 1195969..1197135 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" gene 1195969..1197135 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo downshifts 1197126 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" CDS 1197211..1198161 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" gene 1197211..1198161 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" CDS 1198178..1199089 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" gene 1198178..1199089 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" downshifts 1199103 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" S_feature 1199148..1199255 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1199228..1199233 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199249..1199267 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199257 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" CDS 1199294..1200046 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" gene 1199294..1200046 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" downshifts 1200026 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" CDS complement(1200081..1201073) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" gene complement(1200081..1201073) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" downshifts complement(1200102) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" misc_RNA complement(1201132..1201346) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene complement(1201132..1201346) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" downshifts complement(1201180) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" misc_feature complement(1201365..1201384) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1201378) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" promotor_-35 1201633..1201640 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1201654..1201816 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1201655..1201674 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201655 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" CDS 1201817..1203454 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" gene 1201817..1203454 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" downshifts 1203348 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" S_feature 1203455..1203561 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1203562..1204497 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" gene 1203562..1204497 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" promotor_-10 complement(1203605..1203624) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1203622) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1203640..1203646) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1204501..1205418 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" gene 1204501..1205418 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" CDS 1205423..1206499 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" gene 1205423..1206499 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" CDS 1206501..1207418 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" gene 1206501..1207418 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" downshifts 1207388 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" promotor_-35 1207468..1207471 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1207484 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1207486..1207505 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1207525..1208742 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" gene 1207525..1208742 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" promotor_-35 1208795..1208804 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1208817..1208832 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1208826..1208905 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1208826 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" CDS 1208906..1209484 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" gene 1208906..1209484 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" S_feature 1209485..1209599 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1209536..1209555) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209540) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1209569..1209576) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1209602..1209615 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1209602 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" CDS 1209665..1210060 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" gene 1209665..1210060 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" promotor_no_box complement(1209896..1209996) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1209936) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1210058 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" S_feature 1210103..1210892 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1210103..1210759) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" gene complement(1210103..1210759) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" promotor_-10 complement(1210789..1210807) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210804) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" promotor_-35 complement(1210822..1210827) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1210865..1210872 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210886..1210905 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1210894..1211035 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1210894 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" CDS 1210929..1211069 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" gene 1210929..1211069 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" CDS 1211036..1211692 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" gene 1211036..1211692 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" downshifts 1211682 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" CDS complement(1211687..1211809) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" gene complement(1211687..1211809) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" S_feature 1211727..1211816 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1211795..1211803 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211814..1211832 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1211818..1211882 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1211818 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" CDS 1211883..1213004 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" gene 1211883..1213004 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" promotor_-35 1212658..1212664 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1212676 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" promotor_-10 1212679..1212697 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1212890..1212898 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1212910..1212928 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1212917 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" promotor_-35 1212998..1213004 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213019..1213030 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213028 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" CDS 1213051..1215063 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" gene 1213051..1215063 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" promotor_-35 1213126..1213133 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1213148..1213167 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1213160 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" downshifts 1215010 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" S_feature 1215064..1215365 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1215101..1215268) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" gene complement(1215101..1215268) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" downshifts complement(1215114) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(1215288..1215306) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215304) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" promotor_-35 complement(1215322..1215327) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1215358..1215365 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1215367..1215492 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1215367 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" misc_RNA 1215373..1215511 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" gene 1215373..1215511 /gene="roxS" /locus_tag="BSU_misc_RNA_67" promotor_-10 1215380..1215399 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1215449 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" CDS complement(1215582..1216481) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" gene complement(1215582..1216481) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" downshifts complement(1215613) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1215817..1215822 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1215829 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" promotor_-10 1215838..1215856 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1215845..1217746 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1216478..1216876) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" gene complement(1216478..1216876) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" S_feature complement(1216877..1217056) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1217048..1217067) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217056) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" promotor_-35 complement(1217079..1217086) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1217131..1217676) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" gene complement(1217131..1217676) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" downshifts complement(1217155) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" S_feature complement(1217677..1217879) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1217880..1218452) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" gene complement(1217880..1218452) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" promotor_-10 complement(1218025..1218043) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1218034) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 complement(1218056..1218063) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1218481..1218500) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1218498) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" promotor_-35 1218514..1218517 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1218515..1218522) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1218530 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" promotor_-10 1218533..1218552 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1218577..1218945 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" gene 1218577..1218945 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" CDS 1218974..1219609 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" gene 1218974..1219609 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" CDS 1219628..1220428 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" gene 1219628..1220428 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" CDS 1220491..1221342 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" gene 1220491..1221342 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" downshifts 1221301 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" CDS complement(1221355..1222089) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" gene complement(1221355..1222089) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" downshifts complement(1221377) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" promotor_-35 1222211..1222215 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1222232..1222251 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1222246 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" S_feature 1222247..1222323 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1222324..1224168 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" gene 1222324..1224168 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" misc_feature complement(1222651..1222670) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1222675) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1224170..1224177 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1224191..1224210 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1224197 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" misc_RNA 1224230..1224338 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1224230..1224338 /gene="tswA" /locus_tag="BSU_misc_RNA_14" downshifts 1224333 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" CDS 1224417..1225127 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" gene 1224417..1225127 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" CDS 1225102..1225719 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" gene 1225102..1225719 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" CDS 1225703..1226812 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" gene 1225703..1226812 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" CDS 1226812..1227012 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" gene 1226812..1227012 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" CDS 1227009..1227779 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" gene 1227009..1227779 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" CDS 1227776..1228786 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" gene 1227776..1228786 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" CDS 1228805..1229620 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" gene 1228805..1229620 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" downshifts 1229594 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1229667..1229673 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229686..1229705 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1229696 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" CDS 1229756..1230532 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" gene 1229756..1230532 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" downshifts 1230521 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" promotor_-35 1230580..1230585 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1230601..1230619 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230605 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" promotor_-10 complement(1230617..1230631) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230617) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1230633..1231316 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" gene 1230633..1231316 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" promotor_-35 complement(1230639..1230643) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1231311 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" downshifts 1231399 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" CDS complement(1231410..1231856) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" gene complement(1231410..1231856) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" downshifts complement(1231431) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" S_feature complement(1231857..1231983) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1231984..1232472) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" gene complement(1231984..1232472) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" promotor_-35 1232152..1232158 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232173..1232192 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232191 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1232468..1232472 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232481..1232495 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232499 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1232509..1232528) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232526) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1232542..1232551) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1232558..1232576) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232575) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" promotor_-35 complement(1232592..1232597) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1232609 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" CDS complement(1232624..1233142) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" gene complement(1232624..1233142) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" downshifts complement(1232648) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" downshifts 1232653 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" S_feature complement(1233143..1233240) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1233241..1233558) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" gene complement(1233241..1233558) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" CDS complement(1233599..1233985) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" gene complement(1233599..1233985) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" promotor_-35 1233981..1233985 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233993..1234007 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233995 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1234005..1234024) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1234027) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" S_feature complement(1234029..1234533) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 complement(1234043) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1234082..1234087 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1234103..1234121 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1234105 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" CDS 1234145..1234501 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" gene 1234145..1234501 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" promotor_-35 1234511..1234520 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1234518..1234537) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1234526..1234759) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" gene complement(1234526..1234759) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo upshifts complement(1234533) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" S_feature 1234534..1234720 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1234534..1234551 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1234534 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" promotor_-35 complement(1234551..1234560) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1234577) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" downshifts 1234677 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" upshifts complement(1234731) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1234732..1234741 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1234739..1234746) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1234755..1234774 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1234765 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" CDS 1234783..1234989 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" gene 1234783..1234989 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" CDS 1234826..1235041 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" gene 1234826..1235041 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" promotor_-35 1235013..1235022 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235035..1235054 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235040 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" promotor_-10 complement(1235047..1235061) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1235061) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1235071..1235075) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1235071..1235220 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" gene 1235071..1235220 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" downshifts 1235161 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" S_feature 1235221..1235352 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1235353..1235607 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" gene 1235353..1235607 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" downshifts 1235592 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" downshifts complement(1235611) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" S_feature 1235637..1236737 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1235681..1237960) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" gene complement(1235681..1237960) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" downshifts complement(1235699) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" S_feature complement(1237835..1238009) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1237888..1237896 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237907..1237925 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1237911..1238046 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1237911 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" promotor_-10 complement(1237997..1238016) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238008) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" promotor_-35 1238024..1238030 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1238032..1238036) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238045..1238063 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238048 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" CDS 1238077..1238331 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" gene 1238077..1238331 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" downshifts 1238307 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" downshifts complement(1238397) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" CDS complement(1238404..1238826) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" gene complement(1238404..1238826) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" CDS complement(1238830..1239345) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" gene complement(1238830..1239345) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" CDS complement(1239382..1240104) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" gene complement(1239382..1240104) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" misc_feature complement(1240143..1240162) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1240164) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" promotor_-35 1240213..1240220 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240235..1240254 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240239 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" misc_RNA 1240272..1240392 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 1240272..1240392 /gene="mswA" /locus_tag="BSU_misc_RNA_15" downshifts 1240397 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" CDS 1240460..1241581 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" gene 1240460..1241581 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" CDS 1241574..1242746 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" gene 1241574..1242746 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" downshifts 1242729 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" misc_feature 1242763..1242781 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1242773 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" S_feature 1242774..1244303 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1242779..1243324) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" gene complement(1242779..1243324) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" downshifts complement(1242800) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" CDS complement(1243394..1244584) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" gene complement(1243394..1244584) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" promotor_-10 complement(1244610..1244629) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244614) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" promotor_-35 complement(1244644..1244651) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244678..1244685 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1244689 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" promotor_-10 1244699..1244718 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1244757..1244829 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene 1244757..1244829 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" promotor_-10 complement(1244771..1244788) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244785) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1244809..1244815) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1244819 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" S_feature complement(1244844..1245579) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1244864..1246512 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1244873) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" S_feature complement(1245581..1245669) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1245624) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" CDS complement(1245670..1246899) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" gene complement(1245670..1246899) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" downshifts complement(1245792) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" downshifts 1246469 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" S_feature complement(1246900..1246985) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1246940..1246947 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246962..1246981 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1246971..1246990) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246975 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" upshifts complement(1246989) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" promotor_-35 complement(1247003..1247009) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1247025..1247345 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" gene 1247025..1247345 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" downshifts 1247355 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" S_feature 1247400..1247497 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1247498..1247629 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " gene 1247498..1247629 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" CDS 1247645..1247818 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" gene 1247645..1247818 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" CDS 1247855..1248316 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" gene 1247855..1248316 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" promotor_-35 1248287..1248294 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1248309..1248328 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1248317..1248557 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1248317 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" promotor_-35 1248530..1248537 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248551..1248569 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248559 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" CDS 1248582..1249085 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" gene 1248582..1249085 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" CDS 1249097..1249381 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" gene 1249097..1249381 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" downshifts 1249351 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" upshifts complement(1249383) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1249394..1249397) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1249542..1250069 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" gene 1249542..1250069 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" promotor_-35 1250216..1250221 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250234..1250253 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250237 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" CDS 1250243..1250560 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" gene 1250243..1250560 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" S_feature 1250561..1250796 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1250797..1251552 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" gene 1250797..1251552 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" S_feature 1251553..1251640 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1251597 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" S_feature complement(1251640..1251700) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1251671) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" CDS complement(1251701..1252048) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" gene complement(1251701..1252048) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" promotor_-10 complement(1252080..1252098) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252093) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" S_feature complement(1252095..1252551) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1252109..1252117) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1252511..1252529 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1252523 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" promotor_-10 complement(1252529..1252548) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252551) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" promotor_-35 complement(1252562..1252569) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1252599..1254545 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" gene 1252599..1254545 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" downshifts 1254521 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" promotor_-35 1254621..1254624 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254640..1254659 /Source="Nicolas_upshift_promotors" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254651 /Source="Nicolas_upshifts" /id="U978" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.936063936063936" /xcortree=1565 /SigmaFactorBS="tttattaccggaacctatggtaaaaaaagcGATTttaatgag ctgatttCGGTATACAGTTGAGACAAGatcttattattcacactttaaaggaggtttc c" /listShort="manP, manA, S439, S440, yjdF, yjdI" /GFF_Attribute="listLong" upshifts complement(1254663) /Source="Nicolas_upshifts" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1254672..1254686) /Source="Nicolas_upshift_promotors" /id="U979" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.748251748251748" /psig="0.14985014985015" /xcortree=304 /SigmaFactorBS="tcggacaagatgtaatcgctaacagtttcataggaaaCCTCC TTTAAAGTGTgaataataagatcttgtctcaactgtataccgaaatcagctcattaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1254693..1256645 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" /EC_number="2.7.1.191" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10627040, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627040, 10960106, 23551403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannose-specificenzyme IIBCA component" /protein_id="NP_389083.2" /db_xref="EnsemblGenomes-Gn:BSU12010" /db_xref="EnsemblGenomes-Tr:CAB13058" /db_xref="GOA:O31645" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R48" /db_xref="SubtiList:BG13176" /db_xref="UniProtKB/Swiss-Prot:O31645" /translation="MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGV ENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIP VYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGL VIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDS ASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIG APVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNY EIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQD PLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVT ALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISP ELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPH GKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKL MDDNYRERLLSVQTTEEAYKLLEEIE*" gene 1254693..1256645 /gene="manP" /locus_tag="BSU_12010" /old_locus_tag="BSU12010" CDS 1256660..1257607 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 7934877, 20862359, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 7934877, 20862359, 23551403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6 phosphate isomerase; cupin family" /protein_id="NP_389084.1" /db_xref="EnsemblGenomes-Gn:BSU12020" /db_xref="EnsemblGenomes-Tr:CAB13059" /db_xref="GOA:O31646" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13177" /db_xref="UniProtKB/Swiss-Prot:O31646" /translation="MTTEPLFFKPVFKERIWGGTALADFGYTIPSQRTGECWAFAAHQ NGQSVVQNGMYKGFTLSELWEHHRHLFGQLEGDRFPLLTKILDADQDLSVQVHPNDEY ANIHENGELGKTECWYIIDCQKDAEIIYGHNATTKEELTTMIERGEWDELLRRVKVKP GDFFYVPSGTVHAIGKGILALETQQNSDTTYRLYDYDRKDAEGKLRELHLKKSIEVIE VPSIPERHTVHHEQIEDLLTTTLIECAYFSVGKWNLSGSASLKQQKPFLLISVIEGEG RMISGEYVYPFKKGDHMLLPYGLGEFKLEGYAECIVSHL*" gene 1256660..1257607 /gene="manA" /locus_tag="BSU_12020" /old_locus_tag="BSU12020" S_feature 1257608..1257706 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1257681..1257687 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1257702..1257721 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1257708..1257776 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1257708 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" CDS 1257777..1258259 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" gene 1257777..1258259 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" downshifts 1258239 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" CDS complement(1258305..1258811) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" gene complement(1258305..1258811) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" downshifts complement(1258329) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" misc_feature complement(1258836..1258855) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1258842) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" S_feature complement(1258844..1259029) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1259030..1259425) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" gene complement(1259030..1259425) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" promotor_-10 complement(1259448..1259466) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1259461) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" S_feature complement(1259463..1260163) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1259481..1259486) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1259569..1259576 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259590..1259609 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259601 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" CDS 1259654..1260133 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " gene 1259654..1260133 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" downshifts 1260132 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" CDS complement(1260173..1260367) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" gene complement(1260173..1260367) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" downshifts complement(1260208) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" promotor_-10 complement(1260381..1260396) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260397) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" promotor_-35 complement(1260408..1260417) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1260533..1260862) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" gene complement(1260533..1260862) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" promotor_-10 complement(1260899..1260918) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1260912) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" S_feature complement(1260914..1261481) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1260933..1260938) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1260966..1260970 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1260986..1261005 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1260990..1261491 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1260990 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" CDS complement(1261482..1262471) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" gene complement(1261482..1262471) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" promotor_-10 complement(1262472..1262491) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1262475) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" promotor_-35 complement(1262505..1262510) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1262594..1262842) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" gene complement(1262594..1262842) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" downshifts complement(1262604) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" promotor_-35 1262838..1262842 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262851..1262865 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262860 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1262867..1262886) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262876) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" promotor_-35 complement(1262900..1262909) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1262957..1262964 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1262971..1262990) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1262978..1262997 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1262980) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" upshifts 1262991 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" S_feature 1262992..1263095 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1263004..1263011) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263096..1264499 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" gene 1263096..1264499 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" downshifts 1264488 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" CDS complement(1264539..1265012) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" gene complement(1264539..1265012) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" downshifts complement(1264543) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1265034..1265052) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265052) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1265067..1265072) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1265137..1265304) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" gene complement(1265137..1265304) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" downshifts complement(1265140) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" promotor_-10 complement(1265316..1265334) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265325) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" promotor_-35 complement(1265347..1265354) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265431..1266330 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" gene 1265431..1266330 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" CDS complement(1266339..1266737) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" gene complement(1266339..1266737) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" downshifts complement(1266369) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" promotor_-10 complement(1266766..1266785) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1266785) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1266800..1266807) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1266838..1267413) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" gene complement(1266838..1267413) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" downshifts complement(1266853) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" promotor_-10 complement(1267432..1267450) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267447) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" promotor_-35 complement(1267464..1267470) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1267488..1267494 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267509..1267527 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1267510 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" CDS 1267559..1270516 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" gene 1267559..1270516 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" CDS 1270509..1271069 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" gene 1270509..1271069 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" downshifts 1271062 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" S_feature 1271107..1271225 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1271203..1271206 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271222..1271241 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271227 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" CDS 1271266..1271907 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" gene 1271266..1271907 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" downshifts complement(1271275) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" downshifts 1271880 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" CDS 1271986..1272612 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" gene 1271986..1272612 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" downshifts 1272614 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" downshifts complement(1272617) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" CDS complement(1272643..1272921) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" gene complement(1272643..1272921) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" downshifts complement(1272661) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1272950..1272961) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1272963..1272969) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1272969) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" S_feature complement(1272971..1273387) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1273139 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" misc_feature 1273140..1273159 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1273157..1273311 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1273312..1274502 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" gene 1273312..1274502 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" promotor_-10 complement(1273385..1273404) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1273387) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" promotor_-35 complement(1273418..1273427) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1274525..1275703 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" gene 1274525..1275703 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" CDS complement(1275744..1275932) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" gene complement(1275744..1275932) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" downshifts complement(1275760) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(1275958..1275977) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1275961) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" promotor_-35 complement(1275991..1275997) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1276019..1276026 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1276041..1276060 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1276052 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" promotor_-10 complement(1276067..1276086) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1276071) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1276101..1276108) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1276106..1276918 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" gene 1276106..1276918 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" downshifts 1276897 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" CDS complement(1276964..1277716) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" gene complement(1276964..1277716) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" downshifts complement(1276973) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" CDS complement(1277716..1278468) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" gene complement(1277716..1278468) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" CDS complement(1278588..1279562) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" gene complement(1278588..1279562) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" downshifts complement(1278623) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1279583..1279602) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1279609) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" S_feature complement(1279611..1282117) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1279617..1279624) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1279645..1279651 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279666..1279684 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279669 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" CDS 1279694..1280191 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" gene 1279694..1280191 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" S_feature 1280192..1280305 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1280285..1280289 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280305..1280324 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1280307..1280579 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1280307 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" CDS 1280580..1281002 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" gene 1280580..1281002 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" CDS 1281042..1282220 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" gene 1281042..1282220 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" promotor_no_box 1282051..1282151 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1282109..1282127) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282111 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1282117) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" promotor_-35 complement(1282139..1282147) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1282219 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" promotor_-35 1282328..1282335 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282350..1282369 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282375 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" CDS 1282418..1283839 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" gene 1282418..1283839 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" CDS 1283907..1285286 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" gene 1283907..1285286 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" promotor_-10 complement(1284426..1284445) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284431) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1284459..1284466) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1285311 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" misc_feature 1285321..1285328 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1285323..1285390 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1285391..1286404 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" gene 1285391..1286404 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" CDS 1286410..1287429 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" gene 1286410..1287429 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" CDS 1287454..1288533 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" gene 1287454..1288533 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" CDS 1288530..1289366 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" gene 1288530..1289366 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" CDS 1289414..1290682 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" gene 1289414..1290682 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" promotor_-35 1290626..1290629 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290645..1290649 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290647 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" misc_feature 1290715..1290734 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1290715 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" CDS 1290770..1291771 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " gene 1290770..1291771 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" promotor_no_box complement(1291453..1291553) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1291493) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1291747 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" CDS 1291848..1293290 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" gene 1291848..1293290 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" CDS 1293287..1294780 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" gene 1293287..1294780 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" CDS complement(1294819..1295583) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGSIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" gene complement(1294819..1295583) /gene="yjnA" /locus_tag="BSU_12400" /old_locus_tag="BSU12400" downshifts complement(1294838) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" SCAR join(1295610,1295617) /created_by="User" /modified_by="User" /label="TF8A" N_region 1295611..1295616 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1295619..1295939 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1295619..1295939 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1295948 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" S_feature complement(1295957..1296160) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1295976..1296113) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" gene complement(1295976..1296113) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" downshifts complement(1296000) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" CDS complement(1296199..1296369) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" gene complement(1296199..1296369) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" downshifts complement(1296205) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" CDS complement(1296369..1297115) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" gene complement(1296369..1297115) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" promotor_-10 complement(1296950..1296969) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1296967) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1296985..1296992) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1297141..1297159) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297154) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" promotor_-35 complement(1297175..1297180) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1297225..1298226) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " gene complement(1297225..1298226) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" downshifts complement(1297254) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" CDS complement(1298239..1298856) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" gene complement(1298239..1298856) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" promotor_-10 complement(1298892..1298911) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298894) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" S_feature complement(1298896..1298993) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1298927..1298931) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1298973..1298992) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298993) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" promotor_-35 complement(1299007..1299014) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1299038..1299057) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1299050) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" CDS complement(1299132..1300448) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" gene complement(1299132..1300448) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" downshifts complement(1299147) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1300495..1300514) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1300511) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" promotor_-35 complement(1300529..1300532) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1300731..1300738 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300753..1300772 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1300765..1300836 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1300765 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" CDS 1300837..1301787 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" gene 1300837..1301787 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" downshifts 1301775 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" CDS 1301888..1302034 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" gene 1301888..1302034 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" CDS 1302042..1304192 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" gene 1302042..1304192 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" promotor_no_box 1302931..1303031 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1302991 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1303079 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" CDS 1304204..1305175 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" gene 1304204..1305175 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" S_feature complement(1304532..1305173) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1305218) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" S_feature complement(1305243..1305609) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1305286) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" promotor_-10 complement(1305589..1305604) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305609) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" promotor_-35 complement(1305616..1305625) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1305693..1307042) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " gene complement(1305693..1307042) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" downshifts complement(1305707) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" promotor_-35 1307082..1307089 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1307094..1307113) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307102 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" promotor_-10 1307104..1307123 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1307112) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" S_feature complement(1307114..1307196) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1307124..1307131) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1307153..1307159 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307174..1307193 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307177 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" promotor_-10 complement(1307179..1307198) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307196) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" CDS 1307211..1308029 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" gene 1307211..1308029 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" promotor_-35 complement(1307214..1307217) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1308007 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" promotor_-35 1308086..1308093 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308108..1308127 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308112 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1308158..1308982 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" gene 1308158..1308982 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" CDS 1308999..1309925 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" gene 1308999..1309925 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" CDS 1309931..1310893 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" gene 1309931..1310893 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" promotor_-35 1310625..1310630 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310646..1310664 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310647 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" CDS 1310898..1311905 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" gene 1310898..1311905 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" CDS 1311908..1313557 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" gene 1311908..1313557 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" downshifts 1313551 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" CDS 1313645..1314604 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" gene 1313645..1314604 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" CDS 1314601..1315701 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" gene 1314601..1315701 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" CDS 1315698..1316588 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" gene 1315698..1316588 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" CDS 1316601..1317590 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" gene 1316601..1317590 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" S_feature complement(1316884..1317611) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1317580 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" S_feature 1317625..1318793 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1317633..1318682) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" gene complement(1317633..1318682) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" downshifts complement(1317656) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1318709..1318728) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318720) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" promotor_-35 complement(1318743..1318750) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1318772..1319632) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" gene complement(1318772..1319632) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" promotor_-10 complement(1319657..1319675) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319674) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" promotor_-35 complement(1319691..1319697) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1319706..1319713 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319727..1319746 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319734 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" CDS 1319792..1320310 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" gene 1319792..1320310 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" downshifts 1320301 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" promotor_-35 1320375..1320381 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1320393..1320499 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1320393 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" promotor_-10 1320395..1320406 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1320474..1320477 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320493..1320512 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320501 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" CDS 1320549..1321748 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" gene 1320549..1321748 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" downshifts 1321737 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" S_feature 1321782..1322153 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1321825..1322049) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" gene complement(1321825..1322049) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" promotor_-35 1322129..1322135 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322149..1322160 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322155 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" CDS 1322194..1322925 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" gene 1322194..1322925 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" downshifts 1322903 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" promotor_-35 1322964..1322972 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322983..1323001 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322991 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" CDS 1323017..1323544 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" gene 1323017..1323544 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" CDS 1323534..1324052 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" gene 1323534..1324052 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" promotor_-35 1324046..1324053 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1324067..1324086 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1324070 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" misc_RNA 1324085..1324196 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" gene 1324085..1324196 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" downshifts 1324159 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" CDS 1324274..1324612 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" gene 1324274..1324612 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" CDS 1324612..1324929 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" gene 1324612..1324929 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" promotor_-35 1324929..1324932 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324948..1324967 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324960 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" CDS 1325000..1325902 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" gene 1325000..1325902 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" downshifts 1325893 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" promotor_-35 1325949..1325955 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1325961 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" promotor_-10 1325969..1325988 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1325990..1326200 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" gene 1325990..1326200 /gene="pswB" /locus_tag="BSU_misc_RNA_17" downshifts 1326158 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" CDS 1326253..1327350 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" gene 1326253..1327350 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" promotor_-35 1326440..1326442 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326444..1326448 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326444 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" CDS 1327362..1328609 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" gene 1327362..1328609 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" downshifts 1328600 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" promotor_-35 1328671..1328678 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328693..1328712 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328702 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" CDS 1328735..1329160 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" gene 1328735..1329160 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" downshifts 1329149 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" CDS complement(1329191..1329634) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" gene complement(1329191..1329634) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" downshifts complement(1329225) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(1329661..1329680) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329667) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" promotor_-35 complement(1329695..1329698) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329716..1329722 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329736..1329754 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329742 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" CDS 1329777..1330187 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" gene 1329777..1330187 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" downshifts 1330165 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" CDS 1330214..1330384 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" gene 1330214..1330384 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" S_feature 1330385..1331062 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1330434..1330904) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" gene complement(1330434..1330904) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" downshifts complement(1330458) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1330926..1330945) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1330942) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" S_feature complement(1330944..1331051) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1330961..1330964) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1331020 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" CDS complement(1331077..1333365) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" gene complement(1331077..1333365) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" downshifts complement(1331096) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" S_feature complement(1333366..1333428) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1333388..1333488) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1333428) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" misc_RNA complement(1333493..1333648) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" gene complement(1333493..1333648) /gene="mswB" /locus_tag="BSU_misc_RNA_18" downshifts complement(1333494) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1333681..1333700) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1333693) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" S_feature complement(1333695..1333780) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1333716..1333723) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1333781..1334740) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" gene complement(1333781..1334740) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" S_feature complement(1334741..1334792) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1334785..1334804) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334797) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" promotor_-35 complement(1334818..1334824) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1334909..1334912 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1334925 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" promotor_-10 1334928..1334947 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1334963..1335796 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" gene 1334963..1335796 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" downshifts 1335772 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" CDS complement(1335827..1336591) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" gene complement(1335827..1336591) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" downshifts complement(1335848) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" CDS complement(1336566..1338209) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" gene complement(1336566..1338209) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" CDS complement(1338196..1338795) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" gene complement(1338196..1338795) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" CDS complement(1338797..1339399) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" gene complement(1338797..1339399) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" downshifts complement(1339477) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" misc_RNA complement(1339496..1339608) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene complement(1339496..1339608) /gene="tswB" /locus_tag="BSU_misc_RNA_19" promotor_-35 1339609..1339612 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1339623..1339642) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1339628..1339647 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339639 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1339644) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" promotor_-35 complement(1339657..1339664) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1339710..1340396 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" gene 1339710..1340396 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" CDS 1340400..1341764 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" gene 1340400..1341764 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" CDS 1341761..1342441 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" gene 1341761..1342441 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" promotor_-35 1342470..1342475 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342491..1342509 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342494 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" CDS 1342533..1343045 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" gene 1342533..1343045 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" downshifts 1343031 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" promotor_-35 1343076..1343082 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343096..1343107 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343097 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" CDS 1343128..1343265 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" gene 1343128..1343265 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" downshifts 1343238 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" promotor_-35 1343324..1343331 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343345..1343364 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1343347..1343666 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1343347 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" misc_RNA 1343379..1343532 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1343379..1343532 /gene="swmG" /locus_tag="BSU_misc_RNA_68" promotor_-35 1343644..1343653 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343666..1343685 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1343668..1343769 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1343668 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" CDS 1343770..1345125 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" gene 1343770..1345125 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" downshifts 1345116 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" CDS complement(1345168..1345500) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" gene complement(1345168..1345500) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" promotor_-10 complement(1345516..1345535) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345526) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" S_feature complement(1345528..1345916) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1345551..1345556) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1345588..1345688 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1345648 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" CDS 1345695..1345850 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" gene 1345695..1345850 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" promotor_-35 1345859..1345866 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345873..1345890 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345890 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" promotor_-10 complement(1345901..1345920) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1345916) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" promotor_-35 complement(1345934..1345940) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1345938..1346120 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" gene 1345938..1346120 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" downshifts 1346088 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" promotor_-35 1346145..1346153 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346164..1346182 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1346170..1346252 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1346170 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" CDS 1346253..1346717 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" gene 1346253..1346717 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" downshifts 1346702 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" CDS complement(1346732..1347853) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" gene complement(1346732..1347853) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" promotor_-35 1347141..1347149 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347163..1347182 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1347166..1347944 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1347166 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" promotor_-10 complement(1347882..1347893) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347902) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1347908..1347914) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1347945..1348496 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" gene 1347945..1348496 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" downshifts 1348464 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" CDS complement(1348524..1349336) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" gene complement(1348524..1349336) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" promotor_-10 complement(1349296..1349315) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1349310) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1349329..1349334) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1349437..1349443 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1349454..1349528 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1349454 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" promotor_-10 1349457..1349468 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1349529..1351223 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" gene 1349529..1351223 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" CDS 1351236..1352249 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" gene 1351236..1352249 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" downshifts 1352234 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" CDS complement(1352275..1354110) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" gene complement(1352275..1354110) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" downshifts complement(1352324) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" CDS complement(1354114..1355049) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" gene complement(1354114..1355049) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" promotor_-10 complement(1355020..1355031) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1355030) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" promotor_-35 complement(1355046..1355052) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1355086..1357488) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" gene complement(1355086..1357488) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" downshifts complement(1355118) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" S_feature complement(1357336..1357538) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1357527..1357545) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1357538) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" promotor_-35 complement(1357559..1357566) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1357605..1357612 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357626..1357645 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357638 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" CDS 1357669..1358334 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" gene 1357669..1358334 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" promotor_-10 complement(1358203..1358222) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1358220) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1358236..1358245) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1358329..1358336 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358351..1358370 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358364 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" misc_RNA 1358390..1358523 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" gene 1358390..1358523 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" CDS 1358411..1359385 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" gene 1358411..1359385 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" downshifts 1358474 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" downshifts 1359373 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1359495..1359503 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1359517..1359525 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1359527 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" S_feature 1359530..1359616 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1359589..1359596 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1359610..1359629 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1359618 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" CDS 1359649..1360404 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" gene 1359649..1360404 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" CDS 1360401..1361546 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" gene 1360401..1361546 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" S_feature 1361547..1362706 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1361557..1361751) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" gene complement(1361557..1361751) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" downshifts complement(1361564) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1361794..1361805) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361804) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" promotor_-35 complement(1361820..1361826) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1361882..1362583) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" gene complement(1361882..1362583) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" downshifts complement(1361916) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" S_feature complement(1362584..1362664) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1362656..1362675) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362664) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" promotor_-35 1362680..1362687 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1362689..1362696) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362701..1362720 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1362708 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" CDS 1362754..1363650 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" gene 1362754..1363650 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" downshifts 1363644 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" promotor_-35 1363755..1363759 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363775..1363794 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363779 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" CDS 1363824..1365173 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " gene 1363824..1365173 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" downshifts 1365161 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1365222..1365228 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365242..1365253 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1365250..1365317 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1365250 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" CDS 1365318..1365473 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" gene 1365318..1365473 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" CDS 1365476..1365652 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" gene 1365476..1365652 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" promotor_no_box 1365542..1365642 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1365602 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1365648 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" CDS complement(1365695..1366717) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" gene complement(1365695..1366717) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" downshifts complement(1365718) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" promotor_-10 complement(1366762..1366781) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366778) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" promotor_-35 complement(1366793..1366799) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1366906..1366914 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1366922 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" promotor_-10 1366925..1366943 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1366970..1369186 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" gene 1366970..1369186 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" S_feature complement(1368961..1369901) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1369039..1369046 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369061..1369080 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369063 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" CDS 1369183..1369680 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" gene 1369183..1369680 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" S_feature 1369681..1369920 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1369770..1369895 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" gene 1369770..1369895 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" downshifts 1369888 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" CDS complement(1369929..1370990) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" gene complement(1369929..1370990) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" downshifts complement(1369946) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" CDS complement(1370998..1372191) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" gene complement(1370998..1372191) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" downshifts 1371058 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" downshifts complement(1372278) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" misc_RNA complement(1372284..1372440) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" gene complement(1372284..1372440) /gene="mswC" /locus_tag="BSU_misc_RNA_20" promotor_-10 complement(1372475..1372494) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1372476) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" promotor_-35 complement(1372510..1372517) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1372520..1372523 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1372524..1373303) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" gene complement(1372524..1373303) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" promotor_-10 1372539..1372558 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372548 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1372996..1373003 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1373016..1373035 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1373031 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" S_feature 1373038..1373355 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1373325..1373332 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1373333..1373352) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1373347..1373366 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373347) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" upshifts 1373357 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" promotor_-35 complement(1373368..1373375) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1373398..1374594 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" gene 1373398..1374594 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" promotor_-35 1374576..1374583 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1374598..1374617 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1374617 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" misc_RNA 1374633..1374733 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" gene 1374633..1374733 /gene="mswD" /locus_tag="BSU_misc_RNA_21" downshifts 1374732 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" CDS 1374818..1376035 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" gene 1374818..1376035 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" CDS 1376032..1376739 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" gene 1376032..1376739 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" CDS 1376697..1377326 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" gene 1376697..1377326 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" CDS 1377341..1377877 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" gene 1377341..1377877 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" S_feature complement(1377724..1377917) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1377877 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" CDS complement(1377918..1378238) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" gene complement(1377918..1378238) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" downshifts complement(1377976) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" S_feature complement(1378239..1378328) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1378264..1378270 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378285..1378303 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1378295 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" S_feature 1378296..1378380 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1378310..1378329) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1378327) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" promotor_-35 complement(1378344..1378347) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1378354..1378361 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1378376..1378395 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1378382..1378440 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1378382 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" downshifts complement(1378438) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" CDS 1378441..1378698 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" gene 1378441..1378698 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" downshifts 1378692 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" CDS 1378784..1379215 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" gene 1378784..1379215 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" CDS complement(1379243..1380763) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" gene complement(1379243..1380763) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" downshifts complement(1379255) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" promotor_-35 1379964..1379970 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1379984..1379995 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1379990 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1380771..1380790) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1380792) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" promotor_-35 1380890..1380897 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380912..1380931 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380914 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" CDS 1380956..1381393 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" gene 1380956..1381393 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" downshifts 1381376 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" CDS complement(1381433..1382218) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" gene complement(1381433..1382218) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" downshifts complement(1381452) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" downshifts complement(1381914) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" CDS complement(1382190..1383002) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" gene complement(1382190..1383002) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" promotor_-10 complement(1383033..1383051) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1383049) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" promotor_-35 complement(1383065..1383072) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1383140..1383362) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1383172) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" CDS complement(1383385..1385484) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" gene complement(1383385..1385484) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" downshifts complement(1383407) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" S_feature complement(1385485..1385735) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1385695..1385795) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1385735) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" promotor_-35 1385771..1385776 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385786 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" promotor_-10 1385792..1385810 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385849..1386892 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" gene 1385849..1386892 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" S_feature 1386893..1386984 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1386961..1386965 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386982..1387001 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386986 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" misc_RNA 1387031..1387075 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" gene 1387031..1387075 /gene="qswA" /locus_tag="BSU_misc_RNA_22" downshifts 1387052 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" S_feature 1387097..1387204 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1387205..1387864 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" gene 1387205..1387864 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" CDS 1387857..1388306 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" gene 1387857..1388306 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" CDS 1388299..1389030 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" gene 1388299..1389030 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" CDS 1389048..1389545 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" gene 1389048..1389545 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" S_feature 1389546..1389822 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1389780 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" downshifts complement(1389790) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" S_feature complement(1389859..1390103) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1389900) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" CDS complement(1390104..1390460) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" gene complement(1390104..1390460) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" misc_feature complement(1390491..1390510) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390508) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" promotor_-35 1390526 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1390545..1390563 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390550 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" CDS 1390629..1391375 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" gene 1390629..1391375 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" downshifts 1391430 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" promotor_-35 1391778..1391786 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391800..1391819 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391804 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" CDS 1391856..1393055 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" gene 1391856..1393055 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" promotor_-35 1391938..1391944 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1391959..1391977 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1391965 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" promotor_-35 1393024..1393026 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393046..1393064 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393058 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" CDS 1393071..1393298 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" gene 1393071..1393298 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" misc_feature complement(1393148..1393167) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1393156) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1393299..1393394 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1393395..1394093 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" gene 1393395..1394093 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo S_feature complement(1394046..1394872) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1394074..1394325 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" gene 1394074..1394325 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo misc_feature 1394575..1394590 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1394598..1394809 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1394598 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" downshifts 1394774 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1394861..1394880) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1394883) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" promotor_-35 complement(1394896..1394903) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1394948..1394955 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394970..1394989 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394972 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" CDS 1395008..1395298 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" gene 1395008..1395298 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" S_feature complement(1395335..1395418) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1395378) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" CDS complement(1395419..1395604) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" gene complement(1395419..1395604) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" promotor_-10 complement(1395637..1395656) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395648) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" S_feature complement(1395650..1395994) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1395670..1395677) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395703..1395708 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395724..1395743 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395731 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" CDS 1395770..1395964 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" gene 1395770..1395964 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" downshifts 1395940 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" promotor_-10 complement(1395985..1396003) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1396001) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" promotor_-35 complement(1396020..1396025) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1396263..1396889 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" gene 1396263..1396889 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" downshifts 1396820 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" promotor_-35 1396946..1396951 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1396958 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" promotor_-10 1396967..1396985 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1397007..1398344 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" gene 1397007..1398344 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" CDS 1398395..1398892 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" gene 1398395..1398892 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" promotor_-35 1398741..1398747 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1398756 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1398762..1398780 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1398866 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" promotor_-35 1398987..1398993 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399004..1399023 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1399016 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" S_feature 1399020..1399127 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1399128..1401041 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" gene 1399128..1401041 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" promotor_-10 complement(1399277..1399296) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399294) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1399309..1399318) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1399445..1399464) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1399470) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1399478..1399484) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401022 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" downshifts complement(1401098) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1401309..1401328) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401318) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1401342..1401349) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1401393..1401412 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1401403 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" CDS 1401448..1402539 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" gene 1401448..1402539 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" downshifts 1402188 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" downshifts 1402518 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" S_feature complement(1402552..1402770) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1402563..1402820 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1402757..1402776) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1402770) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" promotor_-35 complement(1402792..1402799) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1402821..1403786 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" gene 1402821..1403786 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" promotor_-35 1403804..1403811 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1403826..1403845 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1403838 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" CDS 1403849..1404715 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" gene 1403849..1404715 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" promotor_-35 1404570..1404574 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404591..1404610 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404599 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" downshifts 1404717 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" misc_RNA 1404762..1404913 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" S_feature 1404762..1404913 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1404762..1404913 /gene="gswA" /locus_tag="BSU_misc_RNA_88" promotor_-35 1404891..1404897 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404911..1404922 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404915 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" CDS 1404944..1407043 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" gene 1404944..1407043 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" promotor_-35 1407061..1407065 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407081..1407100 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1407092 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" CDS 1407141..1407407 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" gene 1407141..1407407 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" CDS 1407407..1409119 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" gene 1407407..1409119 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" downshifts 1409106 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" promotor_-35 1409159..1409165 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1409180..1409191 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1409183 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" CDS 1409210..1409449 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" gene 1409210..1409449 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" S_feature complement(1409230..1410569) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1409527..1410555 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" gene 1409527..1410555 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" downshifts 1410525 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" CDS complement(1410570..1411250) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" gene complement(1410570..1411250) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" promotor_-10 complement(1411260..1411279) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411283) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" promotor_-35 complement(1411294..1411301) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1411335..1411342 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1411356..1411374 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1411362 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" CDS 1411385..1413352 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" gene 1411385..1413352 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" misc_feature complement(1411825..1411840) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1411837) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1413323 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" promotor_-35 1413396..1413398 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1413414..1413433 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1413424 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" downshifts complement(1413466) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" CDS 1413490..1414356 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" gene 1413490..1414356 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" downshifts 1414336 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" CDS complement(1414395..1415168) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" gene complement(1414395..1415168) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" downshifts complement(1414412) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1415200..1415219) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1415210) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" misc_feature 1415443..1415462 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1415456 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" S_feature 1415458..1415561 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1415505..1417619 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" gene 1415505..1417619 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" promotor_-10 complement(1416798..1416816) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1416810) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1416832..1416837) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1417600 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" promotor_-35 1417692..1417700 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417712..1417730 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417724 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" CDS 1417783..1419603 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" gene 1417783..1419603 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" CDS complement(1419614..1420795) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" gene complement(1419614..1420795) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" downshifts complement(1419648) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1420823..1420842) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1420839) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" promotor_-10 complement(1420871..1420889) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1420883) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" S_feature complement(1420885..1420953) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1420904..1420909) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1420947..1420966) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1420953) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" CDS complement(1420997..1421158) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" gene complement(1420997..1421158) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" promotor_-10 complement(1421181..1421200) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1421194) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" promotor_-35 complement(1421214..1421221) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1421295..1421302 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1421314 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" promotor_-10 1421315..1421333 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1421362..1422273 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" gene 1421362..1422273 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" downshifts complement(1421367) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" promotor_-35 1421816..1421824 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1421838..1421855 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1421841 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1422258 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" CDS complement(1422317..1422781) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" gene complement(1422317..1422781) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" downshifts complement(1422335) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1422811..1422830) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422821) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" promotor_-35 complement(1422845..1422852) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1422907..1424199) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" gene complement(1422907..1424199) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" downshifts complement(1422929) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1424223..1424242) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1424227) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" promotor_-35 complement(1424258..1424262) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1424275..1424769) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" gene complement(1424275..1424769) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" promotor_-10 complement(1424785..1424804) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1424801) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" promotor_-35 complement(1424818..1424827) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1424826..1425686) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" gene complement(1424826..1425686) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" misc_feature complement(1425707..1425726) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1425720) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" promotor_-35 1425757..1425764 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1425780..1425799 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1425793 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" CDS 1425829..1426593 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" gene 1425829..1426593 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" S_feature 1426594..1426742 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1426723..1426741 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1426744..1426893 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1426744 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" downshifts complement(1426791) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" CDS 1426894..1428624 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" gene 1426894..1428624 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" CDS 1428690..1429208 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" gene 1428690..1429208 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" downshifts 1429206 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" promotor_-35 1429251..1429256 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1429269..1429288 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1429272 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" CDS 1429304..1429852 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" gene 1429304..1429852 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" S_feature 1429853..1430004 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1430005..1431228 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" gene 1430005..1431228 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" promotor_-10 complement(1431191..1431209) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1431201) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1431207 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(1431224..1431229) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1431277..1431284 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1431296..1431397 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1431296 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" promotor_-10 1431299..1431318 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1431314..1431397 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" gene 1431314..1431397 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" downshifts 1431354 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" promotor_-35 1431408..1431413 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1431428..1431712 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1431428 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" promotor_-10 1431430..1431448 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1431689..1431695 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1431709..1431720 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1431714..1431801 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1431714 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" misc_feature 1431790..1431809 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1431803 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1431874..1432113 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" gene 1431874..1432113 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" S_feature 1432114..1432222 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1432223..1432741 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" gene 1432223..1432741 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" promotor_-35 1432778..1432785 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1432799..1432818 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1432813 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" CDS 1432875..1433072 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" gene 1432875..1433072 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" downshifts 1433068 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" S_feature 1433113..1433209 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1433210..1433653 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" gene 1433210..1433653 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" S_feature 1433654..1433761 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1433729..1433734 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433749..1433768 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433763 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" CDS 1433802..1434683 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" gene 1433802..1434683 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" downshifts 1434662 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" promotor_-35 1434718..1434725 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1434740..1434759 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1434745 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1434795..1435271 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" gene 1434795..1435271 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" CDS 1435261..1436154 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" gene 1435261..1436154 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" CDS 1436170..1436625 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" gene 1436170..1436625 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" promotor_-10 complement(1436441..1436460) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436454) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1436474..1436482) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1436619 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" promotor_-35 1436664..1436671 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1436685..1436704 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1436686 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" CDS 1436730..1437440 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" gene 1436730..1437440 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" downshifts complement(1436739) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1436849..1436853) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436849) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1436871) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1437510..1438634 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" gene 1437510..1438634 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" promotor_-35 1438646..1438652 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1438666..1438677 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1438668 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" promotor_-10 complement(1438672..1438686) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1438696..1438700) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1438696..1438941 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" gene 1438696..1438941 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" upshifts complement(1438697) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1438929 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" S_feature 1438974..1439924 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1438978..1439781) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" gene complement(1438978..1439781) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" downshifts complement(1438990) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(1439832..1439851) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439841) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" promotor_-35 complement(1439865..1439872) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439897..1439904 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1439919..1439938 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1439926..1440017 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1439926 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" CDS 1440018..1440560 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" gene 1440018..1440560 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" CDS 1440632..1441078 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" gene 1440632..1441078 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" downshifts 1441086 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" promotor_-35 1441471..1441478 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1441491 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" promotor_-10 1441493..1441512 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1441544..1442119 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" gene 1441544..1442119 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" downshifts 1442097 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" CDS complement(1442160..1443125) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" gene complement(1442160..1443125) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" downshifts complement(1442173) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" promotor_-35 1442469..1442470 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442488..1442507 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1442494..1443218 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1442494 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 complement(1443146..1443164) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1443167) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" promotor_-35 complement(1443179..1443184) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1443205..1443211 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1443221 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" promotor_-10 1443225..1443244 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1443262..1443861 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" gene 1443262..1443861 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" CDS 1443912..1444931 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" gene 1443912..1444931 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" CDS 1444949..1446241 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" gene 1444949..1446241 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" CDS 1446202..1446723 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" gene 1446202..1446723 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" CDS 1446723..1447196 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" gene 1446723..1447196 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" CDS 1447189..1447422 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" gene 1447189..1447422 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" downshifts 1447401 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" promotor_-35 1447467..1447472 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1447489..1447507 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1447497 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" S_feature 1447509..1447595 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1447585..1447588 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1447597 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1447603..1447622 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1447646..1449403 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" gene 1447646..1449403 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" CDS 1449415..1451229 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" gene 1449415..1451229 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" promotor_-10 complement(1449852..1449871) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449862) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1449886..1449893) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1451280..1451289 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451301..1451316 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451305 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" CDS 1451339..1452034 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" gene 1451339..1452034 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" CDS 1452039..1453172 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" gene 1452039..1453172 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" CDS 1453173..1453865 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" gene 1453173..1453865 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" CDS 1453862..1455055 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" gene 1453862..1455055 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" downshifts 1455033 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" promotor_-35 1455104..1455110 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455124..1455135 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455132 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" promotor_-35 1455177..1455184 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1455199..1455218 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1455204..1455295 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1455204 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" promotor_-35 1455259..1455266 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455280..1455299 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455297 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" CDS 1455335..1456090 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" gene 1455335..1456090 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" upshifts complement(1455483) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1455485..1455487) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1455505) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1456087..1456998 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" gene 1456087..1456998 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" CDS 1457013..1458920 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" gene 1457013..1458920 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" downshifts 1458905 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" promotor_-35 1458989..1458996 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459007..1459026 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459010 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" CDS 1459065..1459646 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" gene 1459065..1459646 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" downshifts 1459631 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" downshifts 1459675 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" CDS complement(1459680..1459949) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" gene complement(1459680..1459949) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" downshifts complement(1459685) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" S_feature complement(1459950..1460015) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1459996..1460015) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460015) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" promotor_-35 1460068..1460075 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1460086..1460105 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1460090 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" CDS 1460130..1461752 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" gene 1460130..1461752 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" downshifts 1461740 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" CDS 1461809..1462720 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" gene 1461809..1462720 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" downshifts 1462725 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" CDS complement(1462754..1463986) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" gene complement(1462754..1463986) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" downshifts complement(1462765) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1464004..1464023) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464028) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" promotor_-35 complement(1464038..1464043) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1464096..1464230) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" gene complement(1464096..1464230) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" downshifts complement(1464107) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1464252..1464270) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464263) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" S_feature complement(1464265..1464330) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1464286..1464291) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1464331..1465338) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" gene complement(1464331..1465338) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" upshifts complement(1465384) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" promotor_-10 complement(1465385..1465393) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1465407..1465415) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1465525..1465534 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1465546 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" promotor_-10 1465547..1465562 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1465549..1465621 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1465622..1465900 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" gene 1465622..1465900 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" downshifts 1465898 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" S_feature complement(1465932..1467561) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1465943..1466047 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1465955) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" promotor_-35 1466029..1466036 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466048..1466067 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466049 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" CDS 1466090..1467376 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" gene 1466090..1467376 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" CDS 1467392..1468225 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" gene 1467392..1468225 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" promotor_-10 complement(1467558..1467576) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1467573) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" promotor_-35 complement(1467592..1467597) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1468288..1468953 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" gene 1468288..1468953 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" downshifts 1468937 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1469044..1469050 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1469065..1469084) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1469065..1469084 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1469077 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" upshifts complement(1469079) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1469108..1470841 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" gene 1469108..1470841 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" S_feature complement(1470236..1470840) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1470830 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" CDS complement(1470875..1472542) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" gene complement(1470875..1472542) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" downshifts complement(1470885) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" CDS complement(1472548..1472757) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" gene complement(1472548..1472757) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" promotor_-10 complement(1472794..1472813) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1472816) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" S_feature complement(1472818..1472995) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1472828..1472831) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1472996) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" promotor_-10 complement(1472998..1473009) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1473023..1473029) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1473068..1473075 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1473089..1473108 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1473105 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" CDS 1473143..1473916 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" gene 1473143..1473916 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" downshifts 1473887 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" CDS complement(1473952..1474506) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" gene complement(1473952..1474506) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" downshifts complement(1473963) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1474528..1474547) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1474538) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" promotor_-35 complement(1474562..1474569) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1474591 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" downshifts complement(1474615) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" CDS complement(1474616..1474774) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" gene complement(1474616..1474774) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" CDS complement(1474681..1474824) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" gene complement(1474681..1474824) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" promotor_-35 1474770..1474774 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1474775..1474843) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1474784..1474798 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474811 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1474827..1474846) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1474856) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" promotor_-35 complement(1474859..1474868) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1474930..1474937 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474951..1474970 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474955 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" CDS 1474988..1475659 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" gene 1474988..1475659 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" promotor_-35 1475327..1475336 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1475349..1475367 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1475361 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1475606 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" promotor_-35 1475834..1475839 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1475856..1475875 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1475857..1476082 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1475857 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" misc_feature complement(1475861..1475880) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1475877) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1475981..1475989) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1475987) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1476003..1476011) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1476083..1477198 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" gene 1476083..1477198 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" CDS 1477202..1478179 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" gene 1477202..1478179 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" S_feature 1478180..1478293 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1478214..1478233) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1478231) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1478248..1478251) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478294..1479622 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" gene 1478294..1479622 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" promotor_-35 1478438..1478445 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478460..1478479 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478463 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" CDS 1479627..1481039 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" gene 1479627..1481039 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" downshifts 1481036 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" CDS complement(1481084..1481458) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" gene complement(1481084..1481458) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" downshifts complement(1481132) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" misc_feature complement(1481489..1481508) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1481499) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" promotor_-35 1481662..1481667 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1481683..1481701 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1481693 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" S_feature 1481697..1481806 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1481729) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" promotor_-35 1481790..1481797 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1481808 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" promotor_-10 1481812..1481831 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1481827..1482037 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" gene 1481827..1482037 /gene="srrA" /locus_tag="BSU_misc_RNA_70" CDS 1481877..1481996 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" gene 1481877..1481996 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" downshifts complement(1481883) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" downshifts 1481983 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" S_feature 1482028..1483631 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1482036..1483508) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" gene complement(1482036..1483508) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" downshifts complement(1482054) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" S_feature complement(1483509..1483604) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1483587..1483606) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1483604) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" promotor_-35 1483611..1483614 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1483621..1483628) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483629..1483648 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483633 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" CDS 1483693..1483959 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" gene 1483693..1483959 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" downshifts 1483941 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" CDS complement(1483992..1484630) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" gene complement(1483992..1484630) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" downshifts complement(1484017) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1484651..1484670) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484675) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" promotor_-35 complement(1484685..1484689) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1484700..1484706 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484721..1484739 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484722 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" promotor_-35 1484760..1484769 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484782..1484801 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484786..1484869 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1484786 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" CDS 1484870..1485058 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" gene 1484870..1485058 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" downshifts complement(1484875) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" downshifts 1485051 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" upshifts complement(1485073) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1485081..1485084) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1485128..1485131 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485148..1485167 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485151 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" CDS 1485198..1485995 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" gene 1485198..1485995 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" CDS 1486021..1486449 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" gene 1486021..1486449 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" downshifts 1486406 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" S_feature 1486450..1487403 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1486525) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" CDS complement(1486527..1487441) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" gene complement(1486527..1487441) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" promotor_-10 complement(1487507..1487526) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487515) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" promotor_-35 complement(1487541..1487548) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1487793..1489358) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" gene complement(1487793..1489358) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" promotor_-10 complement(1489393..1489412) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489404) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" promotor_-35 complement(1489426..1489433) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1489643..1491583 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" gene 1489643..1491583 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" CDS 1491573..1491842 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" gene 1491573..1491842 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" promotor_-35 1491808..1491812 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491826..1491845 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491839 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" CDS 1491842..1492363 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" gene 1491842..1492363 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" CDS 1492360..1492653 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" gene 1492360..1492653 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" CDS complement(1492693..1493304) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" gene complement(1492693..1493304) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" downshifts complement(1492707) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1493336..1493355) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1493345) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" promotor_-35 complement(1493370..1493373) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1493560) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" CDS complement(1493577..1493765) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" gene complement(1493577..1493765) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" downshifts complement(1493631) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1493787..1493806) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1493804) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" promotor_-35 complement(1493819..1493826) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1493832..1493851 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1493839 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" CDS 1493878..1495716 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" gene 1493878..1495716 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" CDS 1495773..1496090 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" gene 1495773..1496090 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" downshifts 1496064 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" downshifts complement(1496139) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" CDS complement(1496146..1496355) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" gene complement(1496146..1496355) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" misc_feature complement(1496369..1496388) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1496384) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" CDS complement(1496438..1497067) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" gene complement(1496438..1497067) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" downshifts complement(1496469) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1496969..1496987) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1496975) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1496999..1497007) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1497102..1497113) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1497107) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" promotor_-35 1497119..1497124 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1497128..1497134) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1497140..1497158 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1497140 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" S_feature 1497141..1497221 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1497222..1498550 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" gene 1497222..1498550 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" S_feature complement(1498406..1498553) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1498449) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" S_feature 1498551..1499141 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1498554..1499039) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" gene complement(1498554..1499039) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" promotor_-10 complement(1499051..1499070) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1499079) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" promotor_-35 complement(1499085..1499092) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1499142..1500071 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" gene 1499142..1500071 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" misc_feature 1499656..1499675 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1499665 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" promotor_-35 1500095..1500098 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1500113..1500132 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1500121 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" CDS 1500169..1500450 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" gene 1500169..1500450 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" downshifts 1500439 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" promotor_-35 1500513..1500516 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1500529..1500655 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1500529 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" promotor_-10 1500534..1500540 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1500656..1501867 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" gene 1500656..1501867 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" promotor_-35 1501877..1501881 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1501896..1501915 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1501915 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" CDS 1501942..1505388 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" gene 1501942..1505388 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" promotor_-10 complement(1504954..1504972) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1504974) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1504988..1504993) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1505368 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" downshifts 1505413 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" downshifts complement(1505445) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" downshifts 1505457 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" CDS complement(1505791..1506711) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" gene complement(1505791..1506711) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" downshifts complement(1505797) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(1506751..1506770) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1506766) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" promotor_-35 complement(1506784..1506791) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1506846..1506853 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1506867..1506886 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1506868..1506973 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1506868 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" S_feature 1506975..1507065 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1506975 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" promotor_-35 1506981..1506984 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1506999..1507015 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1507066..1507983 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" gene 1507066..1507983 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" downshifts 1508012 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" upshifts 1508031 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" misc_feature 1508032..1508037 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1508091..1508096 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508111..1508129 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1508119..1508222 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1508119 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" CDS 1508223..1509293 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" gene 1508223..1509293 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" CDS 1509326..1511194 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" gene 1509326..1511194 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" CDS 1511194..1511817 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" gene 1511194..1511817 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" CDS 1511820..1512152 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" gene 1511820..1512152 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" CDS 1512179..1513072 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" gene 1512179..1513072 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" downshifts 1513047 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" CDS complement(1513104..1513466) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" gene complement(1513104..1513466) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" downshifts complement(1513123) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" promotor_-35 1513459..1513463 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1513472..1513485 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1513490..1513509) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1513494..1513605 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1513494 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" upshifts complement(1513502) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" promotor_-35 complement(1513524..1513531) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1513606..1514052 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" gene 1513606..1514052 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" promotor_-35 1513638..1513645 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1513657..1513676 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1513662 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" promotor_-35 1514061..1514068 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1514082..1514101 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1514093 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" CDS 1514136..1515176 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" gene 1514136..1515176 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" promotor_-10 complement(1515099..1515117) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1515104) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1515133..1515138) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1515156 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" promotor_-35 1515340..1515349 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1515363..1515382 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1515377 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" CDS 1515408..1515806 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" gene 1515408..1515806 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" downshifts complement(1515412) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" CDS 1515822..1516061 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" gene 1515822..1516061 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" downshifts 1516040 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" promotor_-35 1516128..1516135 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1516146..1516165 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1516151 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" CDS 1516177..1516626 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" gene 1516177..1516626 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" downshifts 1516612 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" CDS 1516681..1516953 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" gene 1516681..1516953 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" S_feature complement(1516758..1516981) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1516956..1517076 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" gene 1516956..1517076 /gene="csfG" /locus_tag="BSU_misc_RNA_23" S_feature complement(1516983..1517106) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1517026) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" S_feature 1517077..1517182 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1517107..1517119) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517114) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" promotor_-35 complement(1517134..1517140) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1517163..1517167 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1517183..1517202 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1517184..1517275 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1517184 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" CDS 1517276..1517830 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" gene 1517276..1517830 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" CDS 1517835..1518320 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" gene 1517835..1518320 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" downshifts 1518287 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" CDS complement(1518331..1519557) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" gene complement(1518331..1519557) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" S_feature 1518332..1519606 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1519558..1519659) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1519581..1519588 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1519600..1519619 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1519608..1519737 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1519608 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" promotor_-10 complement(1519654..1519672) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1519669) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" promotor_-35 complement(1519689..1519694) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1519738..1520520 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" gene 1519738..1520520 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" promotor_-35 1520300..1520306 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1520320..1520331 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1520331 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" CDS 1520522..1521547 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" gene 1520522..1521547 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" downshifts 1521431 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" CDS complement(1521564..1522811) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" gene complement(1521564..1522811) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" downshifts complement(1521591) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" promotor_-35 1522728..1522734 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1522748..1522759 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1522752 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" CDS complement(1522808..1522993) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" gene complement(1522808..1522993) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" promotor_-35 1522826..1522830 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1522846..1522865 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1522855..1522990 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1522855 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" promotor_-10 complement(1522884..1522903) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1522894) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" promotor_-35 complement(1522917..1522924) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1522961..1522968 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1522982..1523001 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1522992 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" CDS 1523021..1523539 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" gene 1523021..1523539 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" CDS 1523561..1523740 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" gene 1523561..1523740 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" downshifts 1523720 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" upshifts complement(1523763) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(1523767..1523770) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1523821..1523826 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1523842..1523860 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1523843 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" CDS 1523886..1524467 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" gene 1523886..1524467 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" downshifts 1524468 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" CDS complement(1524524..1525006) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" gene complement(1524524..1525006) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" downshifts complement(1524543) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" downshifts 1524996 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" promotor_-10 complement(1525029..1525048) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1525048) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" promotor_-35 complement(1525062..1525069) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1525106..1525112 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1525124..1525143 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1525126 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" CDS 1525166..1526062 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" gene 1525166..1526062 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" CDS 1526133..1527752 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" gene 1526133..1527752 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" downshifts 1527724 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" promotor_-35 1527786..1527789 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1527804..1527877 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1527804..1527823 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527804 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" downshifts complement(1527861) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" CDS 1527878..1528309 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" gene 1527878..1528309 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" CDS 1528379..1529314 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" gene 1528379..1529314 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" S_feature complement(1528981..1530433) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1529354..1529707 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" gene 1529354..1529707 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" CDS 1529704..1531854 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" gene 1529704..1531854 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" promotor_-10 complement(1530414..1530432) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1530433) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" promotor_-35 complement(1530447..1530453) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1531837 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1531909..1531914 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1531930..1531948 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1531930 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" CDS 1531971..1533911 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" gene 1531971..1533911 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" promotor_-35 1533707..1533713 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1533728..1533736 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1533734 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" downshifts 1533884 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" S_feature 1533929..1533996 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1533966..1533970 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1533986..1534005 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1533998..1534086 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1533998 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" CDS 1534087..1535571 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" gene 1534087..1535571 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" S_feature 1535572..1535682 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1535683..1536657 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" gene 1535683..1536657 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" CDS 1536658..1538013 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" gene 1536658..1538013 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" promotor_-35 1537837..1537842 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1537858..1537876 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1537868 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" CDS 1538074..1539174 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" gene 1538074..1539174 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" S_feature 1539175..1539296 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1539297..1540388 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" gene 1539297..1540388 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" promotor_-35 1539777..1539786 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1539799..1539814 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1539804 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" promotor_no_box 1539810..1539910 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1539870 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" CDS 1540420..1541331 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" gene 1540420..1541331 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" downshifts 1541349 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" CDS 1541461..1542252 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" gene 1541461..1542252 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" CDS 1542249..1542944 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" gene 1542249..1542944 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" CDS 1542967..1543674 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" gene 1542967..1543674 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" CDS 1543692..1544057 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" gene 1543692..1544057 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" promotor_-35 1543909..1543912 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1543928..1543947 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1543944 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" S_feature 1544058..1544230 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1544231..1545553 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" gene 1544231..1545553 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" upshifts complement(1544438) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1544442..1544446) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544461..1544465) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545589..1546737 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" gene 1545589..1546737 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" downshifts 1546711 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" S_feature 1546936..1547039 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1546936 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" misc_feature 1546938..1546957 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1547040..1551341 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" gene 1547040..1551341 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" downshifts 1551338 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" S_feature complement(1551349..1552491) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1551391) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" S_feature 1551469..1551535 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1551471 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" misc_feature 1551472..1551491 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1551489..1551501) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1551501) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1551536..1552465 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" gene 1551536..1552465 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" promotor_-10 complement(1552480..1552499) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1552493) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" promotor_-35 complement(1552514..1552517) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1552528..1553247 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" gene 1552528..1553247 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" S_feature 1553248..1553337 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1553321..1553327 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1553339 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" promotor_-10 1553341..1553352 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1553387..1554169 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" gene 1553387..1554169 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" S_feature 1554170..1554258 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1554223..1554230 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1554243..1554262 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1554260 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1554317..1555111 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" gene 1554317..1555111 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" promotor_-35 1555029..1555032 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1555047..1555066 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1555055 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" misc_RNA 1555124..1555225 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 1555124..1555225 /gene="tswE" /locus_tag="BSU_misc_RNA_24" downshifts 1555212 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" CDS 1555313..1556593 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" gene 1555313..1556593 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" misc_feature complement(1556534..1556550) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1556539) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1556614..1556619 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1556635..1556653 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1556639 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" CDS 1556676..1556921 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" gene 1556676..1556921 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" promotor_-35 1556837..1556845 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1556856..1556874 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1556864 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1556922..1557032 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1557024..1557043 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1557034 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" CDS 1557084..1557920 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" gene 1557084..1557920 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" CDS 1557927..1558619 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" gene 1557927..1558619 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" CDS 1558616..1559071 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" gene 1558616..1559071 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" CDS 1559078..1559350 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" gene 1559078..1559350 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" downshifts 1559339 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" CDS 1559411..1560184 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" gene 1559411..1560184 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" promotor_-35 1559900..1559907 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1559921..1559939 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1559944 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" S_feature 1560185..1560277 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1560278..1560772 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" gene 1560278..1560772 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" promotor_-35 1560785..1560792 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1560806..1560825 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1560813 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" misc_RNA 1560835..1561061 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" gene 1560835..1561061 /gene="iswA" /locus_tag="BSU_misc_RNA_25" downshifts 1561028 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" CDS 1561114..1563879 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" gene 1561114..1563879 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" downshifts 1563870 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" downshifts complement(1563925) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" promotor_-35 1563960..1563966 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1563981..1563992 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1563981 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" CDS 1564024..1564398 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" gene 1564024..1564398 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" promotor_-35 1564430..1564434 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1564449 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" promotor_-10 1564450..1564469 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1564501..1564965 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" gene 1564501..1564965 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" CDS 1564967..1565878 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" gene 1564967..1565878 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" promotor_-35 1565873..1565880 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1565895..1565914 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1565909 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" misc_RNA 1565918..1566034 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1565918..1566034 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" CDS 1566061..1566606 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" gene 1566061..1566606 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" downshifts complement(1566255) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" downshifts 1566597 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" misc_RNA 1566610..1566727 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1566610..1566727 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" CDS 1566780..1568087 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" gene 1566780..1568087 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" misc_RNA 1568088..1568202 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" gene 1568088..1568202 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" CDS 1568233..1569147 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" gene 1568233..1569147 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" CDS 1569131..1570417 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" gene 1569131..1570417 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" CDS 1570414..1571508 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" gene 1570414..1571508 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" CDS 1571493..1574708 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" gene 1571493..1574708 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" CDS 1574705..1575475 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" gene 1574705..1575475 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" CDS 1575475..1576410 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" gene 1575475..1576410 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" CDS 1576379..1577098 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" gene 1576379..1577098 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" CDS 1577077..1577727 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" gene 1577077..1577727 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" downshifts 1577729 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" S_feature 1577774..1577846 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1577826..1577833 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577847..1577866 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577848 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" misc_RNA 1577872..1577977 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" gene 1577872..1577977 /gene="mswE" /locus_tag="BSU_misc_RNA_29" S_feature 1577978..1578138 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1578139..1578840 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" gene 1578139..1578840 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" CDS 1578852..1579916 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" gene 1578852..1579916 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" CDS 1579965..1581113 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" gene 1579965..1581113 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" upshifts complement(1580054) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1580066..1580070) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1580088..1580089) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1581126..1581719 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" gene 1581126..1581719 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" S_feature 1581720..1581817 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1581818..1582591 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" gene 1581818..1582591 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" promotor_-35 1582496..1582503 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582518..1582537 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1582519 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" CDS 1582594..1583379 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" gene 1582594..1583379 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" CDS 1583360..1583848 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" gene 1583360..1583848 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" downshifts 1583828 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" downshifts complement(1583875) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" CDS complement(1583888..1585606) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" gene complement(1583888..1585606) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" promotor_-10 complement(1585628..1585647) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1585642..1585647 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1585642) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" promotor_-35 complement(1585660..1585665) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1585663..1585681 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1585667 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" CDS 1585722..1588394 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" gene 1585722..1588394 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" promotor_-10 complement(1587127..1587146) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1587138) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1587161..1587168) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1588400..1588419 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1588403..1588476 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1588403 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1588477..1589352 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" gene 1588477..1589352 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" CDS 1589429..1589698 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" gene 1589429..1589698 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" misc_feature complement(1589509..1589513) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1589514) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1589706..1590320 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" gene 1589706..1590320 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" CDS 1590324..1590527 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" gene 1590324..1590527 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" downshifts 1590516 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" CDS 1590608..1591828 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" gene 1590608..1591828 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" S_feature complement(1591667..1592242) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1591825..1594242 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" gene 1591825..1594242 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" promotor_-10 complement(1592238..1592256) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592242) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" promotor_-35 complement(1592270..1592276) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1594093..1594097 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1594113..1594132 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1594124 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1594269..1594751 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" gene 1594269..1594751 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" CDS 1594756..1595709 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" gene 1594756..1595709 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" CDS 1595696..1597039 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" gene 1595696..1597039 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" CDS 1597043..1598134 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" gene 1597043..1598134 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" CDS 1598141..1598905 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" gene 1598141..1598905 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" downshifts 1598194 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" CDS 1598899..1600845 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" gene 1598899..1600845 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" promotor_-35 1600754..1600760 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1600774..1600792 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1600790 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" CDS 1600860..1601756 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" gene 1600860..1601756 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" CDS 1601761..1602414 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " gene 1601761..1602414 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" promotor_-35 1602412..1602421 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1602435..1602454 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1602440 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" CDS 1602487..1603131 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" gene 1602487..1603131 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" promotor_-35 1602892..1602898 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1602909 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" promotor_-10 1602913..1602931 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1603022..1603027 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603043..1603061 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1603056 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" S_feature 1603132..1603202 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1603203..1603283 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" gene 1603203..1603283 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" downshifts 1603298 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" S_feature 1603343..1603715 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1603356..1603544) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" gene complement(1603356..1603544) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" downshifts complement(1603372) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" downshifts complement(1603418) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" S_feature complement(1603545..1603637) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1603619..1603638) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1603637) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" promotor_-35 complement(1603654..1603657) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1603688..1603695 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1603710..1603728 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1603717 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" promotor_-35 1603756..1603759 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1603774..1603793 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1603782 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" CDS 1603821..1604183 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" gene 1603821..1604183 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" downshifts complement(1604034) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" CDS 1604199..1605860 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" gene 1604199..1605860 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" S_feature 1605861..1605950 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1605923..1605930 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1605944..1605963 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1605952 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" CDS 1605999..1606661 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" gene 1605999..1606661 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" CDS 1606687..1607589 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" gene 1606687..1607589 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" CDS 1607567..1609615 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" gene 1607567..1609615 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" promotor_-35 1609651..1609658 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1609673..1609692 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1609679 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1609724..1610290 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" gene 1609724..1610290 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" CDS 1610304..1611305 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " gene 1610304..1611305 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" CDS 1611324..1612277 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" gene 1611324..1612277 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" CDS 1612270..1613010 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" gene 1612270..1613010 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" promotor_-35 1613041..1613045 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613061..1613080 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1613066 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1613094..1613327 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" gene 1613094..1613327 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" downshifts 1613308 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" promotor_no_box 1613336..1613436 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1613396..1613466 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1613396 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" CDS 1613467..1614216 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" gene 1613467..1614216 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" downshifts 1614188 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" promotor_-35 1614258..1614264 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1614276..1614295 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1614298 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" CDS 1614317..1617877 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" gene 1614317..1617877 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" S_feature complement(1617811..1618881) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1617897..1618886 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" gene 1617897..1618886 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" downshifts 1618873 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" CDS complement(1618923..1619408) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" gene complement(1618923..1619408) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" downshifts complement(1618926) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" promotor_-10 complement(1619430..1619448) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619446) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" promotor_-35 complement(1619462..1619469) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1619511..1619517 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1619532..1619551 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1619534 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1619585..1619917 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" gene 1619585..1619917 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" downshifts complement(1619588) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" CDS 1619931..1621271 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" gene 1619931..1621271 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" S_feature 1621272..1621376 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1621377..1621649 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" gene 1621377..1621649 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" CDS 1621649..1621894 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" gene 1621649..1621894 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" downshifts 1621866 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" S_feature 1621911..1622015 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1622016..1622402 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" gene 1622016..1622402 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" CDS 1622407..1622931 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" gene 1622407..1622931 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" CDS 1622928..1623659 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" gene 1622928..1623659 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" promotor_-35 1623665..1623672 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1623686..1623705 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1623690 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" misc_RNA 1623738..1623779 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" gene 1623738..1623779 /locus_tag="BSU_misc_RNA_30" CDS 1623799..1624146 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" gene 1623799..1624146 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" downshifts 1624148 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" promotor_-35 1624201..1624207 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1624220..1624288 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1624220 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" promotor_-10 1624221..1624240 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1624289..1625137 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" gene 1624289..1625137 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" promotor_-35 1625158..1625165 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1625178..1625196 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1625188 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1625208..1625975 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" gene 1625208..1625975 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" CDS 1626007..1627737 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" gene 1626007..1627737 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" upshifts complement(1627244) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1627245..1627264) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1627279..1627286) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1627734..1628015 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" gene 1627734..1628015 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" downshifts 1627847 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" S_feature 1628016..1628135 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1628107..1628114 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1628128..1628147 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1628137 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1628188..1629345 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" gene 1628188..1629345 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" promotor_no_box complement(1628260..1628360) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1628300) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1629374..1630276 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" gene 1629374..1630276 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" downshifts 1630266 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" CDS 1630337..1631230 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" gene 1630337..1631230 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" promotor_-35 1631236..1631243 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1631258..1631277 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1631265..1631417 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1631265 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1631418..1633493 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" gene 1631418..1633493 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" downshifts 1633463 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" promotor_-35 1633525..1633530 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1633537 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" promotor_-10 1633546..1633564 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1633569..1634876 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" gene 1633569..1634876 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" promotor_-35 1634882..1634886 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1634903..1634922 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1634913 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1634944..1635858 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" gene 1634944..1635858 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" promotor_-35 1634983..1634987 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1635000 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" promotor_-10 1635003..1635022 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1635871..1636416 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" gene 1635871..1636416 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" CDS 1636433..1637836 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" gene 1636433..1637836 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" CDS 1637876..1638655 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" gene 1637876..1638655 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" downshifts 1638630 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" downshifts 1638674 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" promotor_-35 1638775..1638782 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1638795..1638813 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1638806..1638959 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1638806 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1638934..1638941 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1638956..1638975 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1638961 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1639035..1639424 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" gene 1639035..1639424 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" CDS 1639424..1639876 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" gene 1639424..1639876 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" CDS 1639887..1640207 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" gene 1639887..1640207 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" downshifts complement(1640202) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" CDS 1640253..1641863 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" gene 1640253..1641863 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" CDS 1641876..1642892 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" gene 1641876..1642892 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" S_feature 1642893..1643010 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1642956..1643056) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1642996) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1643011..1643637 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" gene 1643011..1643637 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" CDS 1643634..1644950 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" gene 1643634..1644950 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" CDS 1644953..1645396 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" gene 1644953..1645396 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" CDS 1645408..1646022 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" gene 1645408..1646022 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" CDS 1646035..1647498 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" gene 1646035..1647498 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" CDS 1647495..1647917 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" gene 1647495..1647917 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" CDS 1647939..1648733 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" gene 1647939..1648733 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" CDS 1648773..1648988 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" gene 1648773..1648988 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" CDS 1648985..1649407 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" gene 1648985..1649407 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" CDS 1649441..1650439 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" gene 1649441..1650439 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" CDS 1650429..1651565 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" gene 1650429..1651565 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" CDS 1651591..1651953 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" gene 1651591..1651953 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" CDS 1651968..1652627 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" gene 1651968..1652627 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" CDS 1652620..1653285 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" gene 1652620..1653285 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" CDS 1653300..1653569 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" gene 1653300..1653569 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" CDS 1653577..1654356 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" gene 1653577..1654356 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" CDS 1654356..1655438 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" gene 1654356..1655438 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" CDS 1655471..1657504 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" gene 1655471..1657504 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" CDS 1657504..1658604 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" gene 1657504..1658604 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" promotor_-10 complement(1658481..1658500) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1658488) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1658514..1658523) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1658595..1659491 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" gene 1658595..1659491 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" CDS 1659493..1660566 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" gene 1659493..1660566 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" CDS 1660572..1662590 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" gene 1660572..1662590 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" CDS 1662612..1663082 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" gene 1662612..1663082 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" CDS 1663101..1663730 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" gene 1663101..1663730 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" CDS 1663727..1664227 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" gene 1663727..1664227 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" CDS 1664250..1665014 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" gene 1664250..1665014 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" promotor_-35 1665024..1665030 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1665043..1665546 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" gene 1665043..1665546 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" promotor_-10 1665045..1665056 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1665059 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" promotor_-35 1665542..1665548 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1665563..1665582 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1665565..1665689 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1665565 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1665690..1666430 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" gene 1665690..1666430 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" downshifts 1666412 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" S_feature 1666457..1666531 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1666532..1667413 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" gene 1666532..1667413 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" S_feature 1667414..1667558 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1667559..1668281 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" gene 1667559..1668281 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" CDS 1668283..1668840 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" gene 1668283..1668840 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" downshifts complement(1668787) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" promotor_-35 1668829..1668832 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1668847..1668866 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1668865..1668970 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1668865 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1668971..1669753 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" gene 1668971..1669753 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" CDS 1669757..1670566 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" gene 1669757..1670566 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" promotor_-35 1670547..1670554 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1670569..1670588 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1670570 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" CDS 1670628..1671779 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" gene 1670628..1671779 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" CDS 1671786..1673054 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" gene 1671786..1673054 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" CDS 1673087..1674781 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" gene 1673087..1674781 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" S_feature 1674782..1674889 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1674890..1679203 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" gene 1674890..1679203 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" S_feature 1679204..1679268 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1679214..1679431 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 1679214..1679431 /gene="surG" /locus_tag="BSU_misc_RNA_71" promotor_-35 1679240..1679246 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1679261..1679272 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1679270..1679337 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1679270 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" promotor_-35 1679320..1679326 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1679339..1679532 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1679339 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" promotor_-10 1679340..1679359 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1679533..1680003 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" gene 1679533..1680003 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" downshifts complement(1679854) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" CDS 1680038..1681153 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" gene 1680038..1681153 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" promotor_no_box complement(1680100..1680200) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1680140) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1681167..1681442 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" gene 1681167..1681442 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" CDS 1681444..1681746 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" gene 1681444..1681746 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" CDS 1681766..1683916 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" gene 1681766..1683916 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" promotor_-35 1683811..1683817 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1683826 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" promotor_-10 1683832..1683850 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1683913..1684191 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" gene 1683913..1684191 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo CDS 1684208..1684561 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" gene 1684208..1684561 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" downshifts 1684552 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" CDS 1684643..1685572 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" gene 1684643..1685572 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" promotor_-35 1685357..1685364 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1685378..1685397 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1685387 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" CDS 1685591..1686541 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" gene 1685591..1686541 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" promotor_-35 1686574..1686580 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1686581..1686697 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1686581 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" promotor_-10 1686595..1686614 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1686698..1686967 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" gene 1686698..1686967 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" downshifts 1686950 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" S_feature 1686995..1687080 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1687061..1687064 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687080..1687099 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1687082 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" CDS 1687140..1689257 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" gene 1687140..1689257 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" downshifts 1689040 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" downshifts 1689241 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" S_feature 1689286..1689374 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1689375..1690334 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" gene 1689375..1690334 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" promotor_-10 complement(1689443..1689451) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689446) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1689465..1689472) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1689938..1689943 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1689959..1689977 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1689964 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" CDS 1690374..1691603 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" gene 1690374..1691603 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" downshifts 1691592 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" promotor_-35 1691632..1691637 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1691647 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" promotor_-10 1691653..1691671 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1691681..1691938 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" gene 1691681..1691938 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" S_feature 1691939..1691993 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1691966 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" promotor_-35 1692035..1692044 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1692054..1692123 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1692054 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" promotor_-10 1692058..1692077 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1692124..1693017 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" gene 1692124..1693017 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" CDS 1693020..1693622 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" gene 1693020..1693622 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" misc_feature 1693676..1693695 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1693676..1693747 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1693676 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" CDS 1693748..1694788 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" gene 1693748..1694788 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" S_feature 1694789..1694879 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1694880..1696094 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" gene 1694880..1696094 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" CDS 1696125..1696997 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" gene 1696125..1696997 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" S_feature complement(1696468..1697652) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1697004 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" promotor_-35 1697097..1697100 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1697114 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" promotor_-10 1697116..1697135 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1697175..1698842 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" gene 1697175..1698842 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" promotor_-10 complement(1697639..1697657) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697656) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" promotor_-35 complement(1697673..1697678) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1698830 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" promotor_-35 1698897..1698903 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1698917..1698928 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1698918 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" CDS 1698958..1699695 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" gene 1698958..1699695 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" CDS 1699692..1699904 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" gene 1699692..1699904 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" misc_feature 1699932..1699951 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1699946 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" CDS 1700035..1702398 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" gene 1700035..1702398 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" S_feature 1702399..1702499 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1702460..1702467 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702482..1702501 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702500 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" CDS 1702542..1703267 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" gene 1702542..1703267 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" downshifts 1703254 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" promotor_-35 1703323..1703329 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1703342 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" promotor_-10 1703344..1703355 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1703406..1704614 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" gene 1703406..1704614 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" downshifts 1704572 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" promotor_-35 1704683..1704690 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1704703..1704722 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1704725 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" promotor_-35 1704737..1704740 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1704756..1704768 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1704770 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" CDS 1704794..1706074 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" gene 1704794..1706074 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" CDS 1706071..1707357 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" gene 1706071..1707357 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" downshifts 1707207 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" S_feature 1707358..1707411 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1707412..1708140 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" gene 1707412..1708140 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" promotor_-35 1708156..1708162 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1708174 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" promotor_-10 1708176..1708187 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1708187) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1708198..1708212) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1708221..1708225) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1708221..1708478 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" gene 1708221..1708478 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" downshifts 1708463 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" downshifts complement(1708495) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" promotor_-35 1708536..1708539 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1708554..1708573 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1708554 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" CDS 1708608..1709123 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" gene 1708608..1709123 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo CDS 1709059..1709397 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" gene 1709059..1709397 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo CDS 1709464..1710330 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" gene 1709464..1710330 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" promotor_no_box 1709527..1709627 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1709587 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" downshifts 1710290 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" CDS 1710380..1710961 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" gene 1710380..1710961 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" CDS 1710979..1712229 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" gene 1710979..1712229 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" S_feature 1712230..1712356 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1712336..1712343 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1712358..1712377 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1712358 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" CDS 1712402..1713448 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" gene 1712402..1713448 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" downshifts 1713460 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" S_feature 1713505..1713570 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1713542..1713551 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1713564..1713579 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1713572 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" CDS 1713616..1714791 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " gene 1713616..1714791 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" S_feature 1714792..1714891 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1714865..1714872 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1714886..1714905 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1714893..1715066 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1714893 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" CDS 1715067..1716629 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" gene 1715067..1716629 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" downshifts 1716606 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" CDS 1716698..1717492 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" gene 1716698..1717492 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" promotor_-35 1717247..1717252 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1717268..1717286 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1717288 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" promotor_-35 1717536..1717541 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1717552..1717691 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1717552 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" promotor_-10 1717557..1717575 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1717584) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(1717595..1717608) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1717617..1717621) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1717628) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" CDS 1717692..1717952 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" gene 1717692..1717952 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" downshifts 1717904 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" downshifts complement(1717936) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" downshifts 1717948 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" S_feature 1717993..1718167 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1718151..1718158 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1718169 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1718173..1718192 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1718218..1719261 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" gene 1718218..1719261 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" CDS 1719274..1720452 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" gene 1719274..1720452 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" downshifts 1720434 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" promotor_-35 1720532..1720535 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1720544 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" promotor_-10 1720550..1720569 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1720600..1722129 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" gene 1720600..1722129 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" CDS 1722131..1722562 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" gene 1722131..1722562 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" downshifts 1722545 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" promotor_-35 1722693..1722698 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722714..1722732 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1722722..1722823 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1722722 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" CDS 1722824..1723369 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" gene 1722824..1723369 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" downshifts 1723363 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" downshifts complement(1723370) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" promotor_-35 1723427..1723430 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1723445..1723464 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1723449 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" CDS 1723502..1726078 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" gene 1723502..1726078 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" CDS 1726094..1727977 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" gene 1726094..1727977 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" S_feature complement(1727880..1728374) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1727892 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" downshifts complement(1727902) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" promotor_-35 1728124..1728131 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1728146..1728165 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1728156..1728289 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1728156 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" misc_RNA complement(1728161..1728311) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" gene complement(1728161..1728311) /gene="surX" /locus_tag="BSU_misc_RNA_89" downshifts 1728246 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" CDS complement(1728375..1728830) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" gene complement(1728375..1728830) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" S_feature complement(1728831..1728922) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1728910..1728929) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728922) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" promotor_-35 complement(1728946..1728949) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1728985..1729542) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" gene complement(1728985..1729542) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" promotor_-35 1729626..1729633 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1729646..1729665 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1729648..1729666) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1729651 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" upshifts complement(1729662) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1729663..1730280 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17234808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17234808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of bacillaene synthesis operon" /protein_id="NP_389589.1" /db_xref="EnsemblGenomes-Gn:BSU17080" /db_xref="EnsemblGenomes-Tr:CAB13580" /db_xref="GOA:O34381" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12647" /db_xref="UniProtKB/Swiss-Prot:O34381" /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLG ALRHYFSTQDELLAFAMKLVQEKVTDRIKDIAVRDLLPKEKVLQILLEMVPTNEETIR EMEVWFAFTAYARHKKDMFDASHDGIFSGMRNLIAYLDESDLLKQNADKDIEAERLYA LVDGLALHAMLDPVRVNKDRIKRVIMQHVESICVEDTRETQKRHP*" gene 1729663..1730280 /gene="pksA" /locus_tag="BSU_17080" /old_locus_tag="BSU17080" promotor_-35 complement(1729681..1729686) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1730268 /Source="Nicolas_upshifts" /id="D926" /incds=0 /nref=121 /ntot=233 /MaxReadThrough="1.91611" /MaxDrop="4.92546" /score="24.8248143" /energy="-17.1" /TU="NA" /idTUdmin="U1367" /TUdmin=0 /isTUend="TRUE" misc_feature 1730387..1730406 /Source="Nicolas_upshift_promotors" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1730400..1730469 /Source="Nicolas_S_feature" /locus_tag="new_1782643_1782712" /HighExp="T3.0H, HiOs, T2.30H, T2.0H, BC, T3.30H, M9-tran, MG 150, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S614" upshifts 1730400 /Source="Nicolas_upshifts" /id="U1369" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95904095904096" /psig="0.999000999001" /xcortree=2952 /SigmaFactorBS="tttcaaagaacaaggatctctgaaaaaaatggaaaacaatca tgctgTTTGGTAAAGTGGAATGAAAgacggactgaggggtgaacactggtccatcgtt t" /listShort="S614, pksB, S615" /listLong="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" CDS 1730470..1731147 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" /EC_number="3.1.2.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in bacillaene synthesis" /protein_id="NP_389590.1" /db_xref="EnsemblGenomes-Gn:BSU17090" /db_xref="EnsemblGenomes-Tr:CAB13581" /db_xref="GOA:O34769" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12648" /db_xref="UniProtKB/Swiss-Prot:O34769" /translation="MNLTYKVHPIKTRYQGWTNYCYIIEDIVSRSAIVVDPSWELSKI TTTLSELEAELKAVALTHSHYDHVNLVDPLTKMFNAQVYMSKKEIDYYQFRCRNLISL DDHQTISIGNTRAQCLLTPGHTAGGMCYLFSESIFTGDTVFTEGCGICEDDGSSAEEM FDSIQRIKSEVSPHVRVYPGHSFGKSPGHSIKDLYQHNIYFQIDKKEYFVKFRTRKNQ KGIFDFK*" gene 1730470..1731147 /gene="pksB" /locus_tag="BSU_17090" /old_locus_tag="BSU17090" S_feature 1731148..1731415 /Source="Nicolas_S_feature" /locus_tag="new_1783391_1783658" /HighExp="HiOs, T2.0H, M0t90, S2, S1, T4.0H, T-5.40H, Lbstat, M9-tran, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S615" CDS 1731257..1731523 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513956.1" /translation="MKRIIMIWRPICNPGLFSYVLLYLLILYSSMEKSRKTMEQTVGK INLTDNIYRGYHQHEHATIYPVITIIKSYRSETHLLIGRVALRE*" gene 1731257..1731523 /locus_tag="BSU_17099" /old_locus_tag="BSU17099" promotor_-35 1731392..1731399 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1731414..1731433 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1731417..1731519 /Source="Nicolas_S_feature" /locus_tag="new_1783660_1783762" /HighExp="S2, M0t90, M9-stat, HiOs, Lbstat, BC, M40t90, T2.30H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.62175899999999995" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S616" upshifts 1731417 /Source="Nicolas_upshifts" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" CDS 1731520..1732386 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" /EC_number="2.3.1.39" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16707694, 16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl-CoA-acyltransferase involved in bacillaene synthesis" /protein_id="NP_389591.1" /db_xref="EnsemblGenomes-Gn:BSU17100" /db_xref="EnsemblGenomes-Tr:CAB13582" /db_xref="GOA:O34825" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="PDB:5DZ6" /db_xref="SubtiList:BG12649" /db_xref="UniProtKB/Swiss-Prot:O34825" /translation="MITYVFPGQGSQKQGMGSGLFDEFKELTDQADEILGYSIKRLCL ENPYSNLNKTQFTQPALYVVNALSYLKKIRDEEVKPDFVAGHSLGEYNALFAAEAFDF ETGLQLVRKRGELMSLISNGGMAAVMGLNEEQVAKALKEYHLHDVDIANVNAPYQIVI SGKKDEIEKAASLFETMTEVTMVLPLNVSGAFHSRYMNKAKEEFEEFLHAFYFSPPSI PVISNVYAKPYTYEFMKQTLADQINHSVKWTDSISYLMKKGHMEFEEVGPGNVLTGLI HRIKKDAEAMPR*" gene 1731520..1732386 /gene="pksC" /locus_tag="BSU_17100" /old_locus_tag="BSU17100" S_feature 1732387..1732889 /Source="Nicolas_S_feature" /locus_tag="new_1784630_1785132" /HighExp="S2, Lbstat, M0t90, M40t90, S1, T1.0H, HiOs, T2.30H, M9-tran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S617" CDS 1732890..1733864 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389592.2" /db_xref="EnsemblGenomes-Gn:BSU17110" /db_xref="EnsemblGenomes-Tr:CAB13583" /db_xref="GOA:O34877" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="SubtiList:BG12650" /db_xref="UniProtKB/Swiss-Prot:O34877" /translation="MNEPLVFMFSGQGSQYYHMGKELFKENTVFRQSMLEMDAIAARR IGTSIVEEIYHPGKRVSDPFDSILFSHPAIFMIEYSLYKVLEDRGIYPDYVLGSSLGE FAAAAVSGVSDAEDMLDCILEQAIIIQNSCDKGKMLAILDKPQLLNDHPQLFGNSELI SINYDSHFVISGEEDHIRKIMEDLKEKQILCQLLPVSYAFHSSLIDPAESAYAEFLRS KSFQKPSIPIVSSLTGSCLHVMDENFFWNAVRKPMMFREAIRYLESQHTCKFIDLGPS GTLAAFVKQLIPGDSADRCCSIITPFHQELKNLNTVEYFRTPERKFTR*" gene 1732890..1733864 /gene="pksD" /locus_tag="BSU_17110" /old_locus_tag="BSU17110" CDS 1733861..1736164 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme involved in bacillaene synthesis" /protein_id="NP_389593.3" /db_xref="EnsemblGenomes-Gn:BSU17120" /db_xref="EnsemblGenomes-Tr:CAB13584" /db_xref="GOA:O34787" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR014179" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="PDB:5DZ7" /db_xref="SubtiList:BG12651" /db_xref="UniProtKB/Swiss-Prot:O34787" /translation="MITYVFPGQGSQQKGMGQGLFEQYQHLTDQADQILGYSIEKLCT EKSYLDVNHTEYTQPALYVVNALSYLKRVEETGRKPDFAAGHSLGEYNALMAAGAFDF ETGLRLVKKRGELMGRITGGGMAAVIGLSKEQVTAVLEEHRLYDIDVANENTPQQIVI SGPKKEIEKARAVFENTKDVKLFHPLNVSGAFHSRYMNEAKQVFKQYIDSFQFAPLAI PVISNVYAEPYHQDRLKDTLSEQMDNTVKWTDSIRFLMGRGEMEFAEIGPGTVLTGLI HRIKNEAEPLTYIPKKNPAISAHLKEQRNVQAGITAESLGSAEFKQDYHLTYAYLAGG MYRGIASKEMVVKLSRAGMMGFFGTGGLSLKEVEDAIHAIQGELGKGQAYGINLVHNM KHTESEEKMIDLLLRNQVSIVEASAFLSVTPVLVRYRAKGVKRNQNGDVICSNRLIAK ISRPEVAESFLSPAPENMLQKLLGENKITMNEAELLRCIPMADDICVEADSGGHTDGG VAYSLMPAMTSLRDEMMKKYQYRKKIRVGAAGGIGTPEAAMAAFMLGADFILTGSINQ CTVEAATSDKVKDLLQQMNVQDTAYAPAGDMFESGSKVQVLKKGVFFPARANKLYELY QRYGSIRELDAKMLAQLEEKYFKRSIEDIYKDIALHYPAADIEKAEQNPKHKMALIFR WYFRYSSKLAISGSEHSKVDYQIHCGPALGAFNQWVKGSQLENWRNRHVDEIGKKLMT ETAVLLHERMQSMYQPSHETDNIKIKV*" gene 1733861..1736164 /gene="pksE" /locus_tag="BSU_17120" /old_locus_tag="BSU17120" CDS 1736226..1736474 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl-carrier protein involved in bacillaene synthesis" /protein_id="NP_570904.1" /db_xref="EnsemblGenomes-Gn:BSU17130" /db_xref="EnsemblGenomes-Tr:CAE01454" /db_xref="GOA:Q7PC63" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG14186" /db_xref="UniProtKB/Swiss-Prot:Q7PC63" /translation="MDKQRIFEVLITNICEVLPELDGHRFEPEDQLVELGADSVDRAE IITMVLEDLSLKIPRIELSGVKNIGELAEVLYDKVQSA*" gene 1736226..1736474 /gene="acpK" /locus_tag="BSU_17130" /old_locus_tag="BSU17130" CDS 1736452..1737699 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16757561, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase converting malonyl-S-AcpK to acetyl-S-AcpK for bacillaene-related polyketide synthesis" /protein_id="NP_389594.2" /db_xref="EnsemblGenomes-Gn:BSU17140" /db_xref="EnsemblGenomes-Tr:CAB13585" /db_xref="GOA:P40804" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020841" /db_xref="SubtiList:BG10925" /db_xref="UniProtKB/Swiss-Prot:P40804" /translation="MTKCNLPEVVVTGVGVTASIGQGKEDFASSLLSGRHAFDVMKRS GRQKDSRFIGAEIASLSYPDRLSKKMLRKASFSSRAALVTLTEAWEEAELDDADSSRI GLVVGGSNFQQRENFEVYERYQDRSGFISPAYGLSFMDSDLCGICTDQFGITGLAYTV GGASASGQLAVIHAIQQVLSGEVDTCIALGALMDLSYMECEALRALGAMGTDKYADEP ENACRPFDQNRDGFIYGESCGALVIERKETALRRGLKPYAALSGWSIKLDGNRNPDPS LEGEIHVIQKALERARLLPEDIDYINPHGTGSFIGDEIELKALRACRLSHAYINATKS ITGHGLSAAGIVEIISVLLQMKKSALHPSRNLDHPIDDSFHWVNEKSISYRIKNALSL SMGFGGMNTAVCIQNIEKCGGES*" gene 1736452..1737699 /gene="pksF" /locus_tag="BSU_17140" /old_locus_tag="BSU17140" CDS 1737700..1738962 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-S-AcpK beta-ketothioester bacillaene intermediate transferase" /protein_id="NP_389595.2" /db_xref="EnsemblGenomes-Gn:BSU17150" /db_xref="EnsemblGenomes-Tr:CAB13586" /db_xref="GOA:P40830" /db_xref="InterPro:IPR013528" /db_xref="InterPro:IPR013746" /db_xref="InterPro:IPR016039" /db_xref="PDB:4YXQ" /db_xref="PDB:4YXT" /db_xref="PDB:4YXV" /db_xref="SubtiList:BG10926" /db_xref="UniProtKB/Swiss-Prot:P40830" /translation="MVSAGIEAMNVFGGTAYLDVMELAKYRHLDTARFENLLMKEKAV ALPYEDPVTFGVNAAKPIIDALSEAEKDRIELLITCSESGIDFGKSLSTYIHEYLGLN RNCRLFEVKQACYSGTAGFQMAVNFILSQTSPGAKALVIASDISRFLIAEGGDALSED WSYAEPSAGAGAVAVLVGENPEVFQIDPGANGYYGYEVMDTCRPIPDSEAGDSDLSLM SYLDCCEQTFLEYQKRVPGANYQDTFQYLAYHTPFGGMVKGAHRTMMRKVAKVKTSGI ETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFDTPKRIGCFSYGSGCCSEF YSGITTPQGQERQRTFGIEKHLDRRYQLSMEEYELLFKGSGMVRFGTRNVKLDFEMIP GIMQSTQEKPRLFLEEISEFHRKYRWIS*" gene 1737700..1738962 /gene="pksG" /locus_tag="BSU_17150" /old_locus_tag="BSU17150" CDS 1738950..1739729 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase for bacillaene biosynthesis" /protein_id="NP_389596.1" /db_xref="EnsemblGenomes-Gn:BSU17160" /db_xref="EnsemblGenomes-Tr:CAB13587" /db_xref="GOA:P40805" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:3HP0" /db_xref="SubtiList:BG10927" /db_xref="UniProtKB/Swiss-Prot:P40805" /translation="MDLVTYQTIKVRFQASVCYITFHRPEANNTINDTLIEECLQVLN QCETSTVTVVVLEGLPEVFCFGADFQEIYQEMKRGRKQASSQEPLYDLWMKLQTGPYV TISHVRGKVNAGGLGFVSATDIAIADQTASFSLSELLFGLYPACVLPFLIRRIGRQKA HYMTLMTKPISVQEASEWGLIDAFDAESDVLLRKHLLRLRRLNKKGIAHYKQFMSSLD HQVSRAKATALTANQDMFSDPQNQMGIIRYVETGQFPWEDQ*" gene 1738950..1739729 /gene="pksH" /locus_tag="BSU_17160" /old_locus_tag="BSU17160" CDS 1739769..1740518 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="decarboxylase involved in bacillaene synthesis" /protein_id="NP_389597.2" /db_xref="EnsemblGenomes-Gn:BSU17170" /db_xref="EnsemblGenomes-Tr:CAB13588" /db_xref="GOA:P40802" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="PDB:4Q1G" /db_xref="PDB:4Q1H" /db_xref="PDB:4Q1I" /db_xref="PDB:4Q1J" /db_xref="PDB:4Q1K" /db_xref="SubtiList:BG10928" /db_xref="UniProtKB/Swiss-Prot:P40802" /translation="MTHSVVELIEIESAIIQVKMQDRTHKNAFSQELTDDLIQAFEYI RQNPKYKAVILTGYDNYFASGGTQEGLLRIQQGLTKFTDDNLYSLALDCEIPVIAAMQ GHGIGGGFVMGLFADIVILSRESVYTANFMKYGFTPGMGATFIVPKKLGFSLAQEILL NAGSYRGADLEKRGVPFKVLPRAEVLDYAVELAQELAEKPRNSLVTLKDHLVAPLRDQ LPRVIEQELMMHEKTFHHEEVKSRIKGLYGN*" gene 1739769..1740518 /gene="pksI" /locus_tag="BSU_17170" /old_locus_tag="BSU17170" CDS 1740563..1755694 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 17234808, 17827323, 26284661, 26268540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389598.3" /db_xref="EnsemblGenomes-Gn:BSU17180" /db_xref="EnsemblGenomes-Tr:CAB13589" /db_xref="GOA:P40806" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:4J1Q" /db_xref="PDB:4J1S" /db_xref="PDB:4NA1" /db_xref="PDB:4NA2" /db_xref="PDB:4NA3" /db_xref="PDB:5KTK" /db_xref="SubtiList:BG10929" /db_xref="UniProtKB/Swiss-Prot:P40806" /translation="MRNNDNIRILTNPSVSHGEPLHISEKQPATIPEVLYRTATELGD TKGIIYLQPDGTEVYQSYRRLWDDGLRIAKGLRQSGLKAKQSVILQLGDNSQLLPAFW GCVLTGVVPAPLAVPPTYAESSSGTQKLKDAWTLLDKPAVITDRGMHQEMLDWAKEQG LEGFRAIIVEDLLSAEADTDWHQSSPEDLALLLLTSGSTGTPKAVMLNHRNIMSMVKG IIQMQGFTREDITFNWMPFDHVGGIGMLHLRDVYLGCQEINVSSETILMEPLKWLDWI DHYRASVTWAPNFAFGLVTDFAEEIKDKKWDLSSMRYMLNGGEAMVAKVGRRILELLE PHGLPADAIRPAWGMSETSSGVIFSHEFTRAGTSDDDHFVEIGSPIPGFSMRIVNDHN ELVEEGEIGRFQVSGLSVTSGYYQRPDLNESVFTEDGWFETGDLGFLRNGRLTITGRT KDAIIINGINYYSHAIESAVEELPEIETSYTAACAVRLGQNSTDQLAIFFVTSAKLND EQMSQLLRNIQSHVSQVIGVTPEYLLPVQKEEIPKTAIGKIQRTQLKTSFENGEFDHL LHKPNRMNDAVQDEGIQQADQVKRVREEIQKHLLTCLTEELHVSHDWVEPNANIQSLG VNSIKMMKLIRSIEKNYHIKLTAREIHQYPTIERLASYLSEHEDLSSLSADKKGTDTY KTEPERSQATFQPLSEVQKGLWTLQKMSPEKSAYHVPLCFKFSSGLHHETFQQAFGLV LNQHPILKHVIQEKDGVPFLKNEPALSIEIKTENISSLKESDIPAFLRKKVKEPYVKE NSPLVRVMSFSRSEQEHFLLVVIHHLIFDGVSSVTFIRSLFDTYQLLLKGQQPEKAVS PAIYHDFAAWEKNMLAGKDGVKHRTYWQKQLSGTLPNLQLPNVSASSVDSQFREDTYT RRLSSGFMNQVRTFAKEHSVNVTTVFLSCYMMLLGRYTGQKEQIVGMPAMVRPEERFD DAIGHFLNMLPIRSELNPADTFSSFISKLQLTILDGLDHAAYPFPKMVRDLNIPRSQA GSPVFQTAFFYQNFLQSGSYQSLLSRYADFFSVDFVEYIHQEGEYELVFELWETEEKM ELNIKYNTGLFDAASISAMFDHFVYVTEQAMLNPSQPLKEYSLLPEAEKQMILKTWNA TGKTYPYITFHELFEQQAKKTPDRAAVSYEGQTLTYRELDEKSTQLAIYLQAHGVGPD RLAGIYVDRSLDMLVGLLAILKAGGAYVPLDPSYPAERLEYMLEDSEVFITLTTSELV NTLSWNGVTTALLDQDWDEIAQTASDRKVLTRTVTPENLAYVIYTSGSTGKPKGVMIP HKALTNFLVSMGETPGLTAEDKMLAVTTYCFDIAALELFLPLIKGAHCYICQTEHTKD VEKLKRDIRAIKPTVMQATPATWKMLFYSGWENEESVKILCGGEALPETLKRYFLDTG SEAWNMFGPTETTIWSAVQRINVECSHATIGRPIANTQIYITDSQLAPVPAGVPGELC IAGDGVAKGYYKKEELTDSRFIDNPFEPGSKLYRTGDMARWLTGGRIEYIGRIDNQVK IRGFRIELGDIESRLSEHPGILECVVVADMDNLAAYYTAKHANASLTARELRHFVKNA LPAYMVPSYFIQLDHMPLTPNGKIDRNSLKNIDLSGEQLKQRQTSPKNIQDTVFTIWQ EVLKTSDIEWDDGFFDVGGDSLLAVTVADRIKHELSCEFSVTDLFEYSTIKNISQYIT EQRMGDASDHIPTDPAAHIEDQSTEMSDLPDYYDDSVAIIGISCEFPGAKNHDEFWEN LRDGKESIAFFNKEELQRFGISKEIAENADYVPAKASIDGKDRFDPSFFQISPKDAEF MDPQLRMLLTHSWKAIEDAGYAARQIPQTSVFMSASNNSYRALLPSDTTESLETPDGY VSWVLAQSGTIPTMISHKLGLRGPSYFVHANCSSSLIGLHSAYKSLLSGESDYALVGG ATLHTESNIGYVHQPGLNFSSDGHIKAFDASADGMIGGEGVAVVLLKKAADAVKDGDH IYALLRGIGVNNDGADKVGFYAPSVKGQADVVQQVMNQTKVQPESICYVEAHGTGTKL GDPIELAALTNVYRQYTNKTQFCGIGSVKTNIGHLDTAAGLAGCIKVVMSLYHQELAP SVNYKEPNPNTDLASSPFYVVDQKKTLSREIKTHRAALSSFGLGGTNTHAIFEQFKRD SDKGKIDGTCIVPISAKNKERLQEYAEDILAYLERRGFENSQLPDFAYTLQVGREAME HRVVFIADHVNELKQRLTDFINGNTAIEGCFQGSKHNAREVSWLTEDEDSAELIRKWM AKGKVNKLAEMWSKGAHIDWMQLYKGERPNRMSLPTYPFAKERYWPSQDDRKPVAQIS GNQTGIGSIHPLLHQNTSDFSEQKFSSVFTGDEFFLRDHVVRGKPVLPGVAYLEMAYA AINQAAGSEIGQDVRIRLNHTVWVQPVVVDRHSAQVDISLFPEEDGKITFDIYSTQED GDDPVIHSQGSAELASAAETPVADLTEMSRRCGKGKMSPDQFYEEGRSRGMFHGPAFQ GIKNVNIGNREVLAQLQLPEIVSGTNEQFVLHPSIMDSALQTATICIMQELTDQKLIL PFALEELEVIKGCSSSMWAYARLSDSDHSGGVVQKADIDVIDESGTVCVRIKGFSTRV LEGEVHTSKPSTRHERLMLEPVWEKQNEEREDEDLSYTEHIIVLFETERSVTDSIASH MKDARVITLNEAVGHIAERYQCYMQNIFELLQSKVRKLSAGRIIIQAIVPLEKEKQLF AGVSGLFKTAEIEFSKLTAQVIEIEKPEEMIDLHLKLKDDSRRPFDKQIRYEAGYRFV KGWREMVLPSADTLHMPWRDEGVYLITGGAGSLGLLFAKEIANRTGRSTIVLTGRSVL SEDKENELEALRSIGAEVVYREADVSDQHAVRHLLEEIKERYGTLNGIIHGAGSSKDR FIIHKTNEEFQEVLQPKVSGLLHVDECSKDFPLDFFIFFSSVSGCLGNAGQADYAAAN SFMDAFAEYRRSLAASKKRFGSTISFNWPLWEEGGMQVGAEDEKRMLKTTGMVPMPTD SGLKAFYQGIVSDKPQVFVMEGQLQKMKQKLLSAGSKAKRNDQRKADQDQGQTRKLEA ALIQMVGAILKVNTDDIDVNTELSEYGFDSVTFTVFTNKINEKFQLELTPTIFFEYGS VQSLAEYVVAAYQGEWNQDATAKGKDERTNLVHSLSSLEASLSNMVSAILKVNSEDID VNTELSEYGFDSVTFTVFTNKINEEFQLELTPTIFFEYGSLHSLAEYLTVEHGDTLVQ EREKPEGQEELQTKSSEAPKITSRRKRRFTQPIIAKAERNKKQAADFEPVAIVGISGR FPGAMDIDEFWKNLEEGKDSITEVPKDRWDWREHYGNPDTDVNKTDIKWGGFIDGVAE FDPLFFGISPREADYVDPQQRLLMTYVWKALEDAGCSPQSLSGTGTGIFIGTGNTGYK DLFHRANLPIEGHAATGHMIPSVGPNRMSYFLNIHGPSEPVETACSSSLVAIHRAVTA MQNGDCEMAIAGGVNTILTEEAHISYSKAGMLSTDGRCKTFSADANGYVRGEGVGMVM LKKLEDAERDGNHIYGVIRGTAENHGGRANTLTSPNPKAQADLLVRAYRQADIDPSTV TYIEAHGTGTELGDPIEINGLKAAFKELSNMRGESQPDVPDHRCGIGSVKSNIGHLEL AAGISGLIKVLLQMKHKTLVKSLHCETLNPYLQLTDSPFYIVQEKQEWKSVTDRDGNE LPRRAGISSFGIGGVNAHIVIEEYMPKANSEHTATEQPNVIVLSAKNKSRLIDRASQL LEVIRNKKYTDQDLHRIAYTLQVGREEMDERLACVAGTMQELEEKLQAFVDGKEETDE FFRGQSHRNKETQTIFTADEDMALALDAWIRKRKYAKLADLWVKGVSIQWNTLYGETK PRLISLPSYPFAKDHYWVPAKEHSERDKKELVNAIEDRAACFLTKQWSLSPIGSAVPG TRTVAILCCQETADLAAEVSSYFPNHLLIDVSRIENDQSDIDWKEFDGLVDVIGCGWD DEGRLDWIEWVQRLVEFGHKEGLRLLCVTKGLESFQNTSVRMAGASRAGLYRMLQCEY SHLISRHMDAEEVTDHRRLAKLIADEFYSDSYDAEVCYRDGLRYQAFLKAHPETGKAT EQSAVFPKDHVLLITGGTRGIGLLCARHFAECYGVKKLVLTGREQLPPREEWARFKTS NTSLAEKIQAVRELEAKGVQVEMLSLTLSDDAQVEQTLQHIKRTLGPIGGVIHCAGLT DMDTLAFIRKTSDDIQRVLEPKVSGLTTLYRHVCNEPLQFFVLFSSVSAIIPELSAGQ ADYAMANSYMDYFAEAHQKHAPIISVQWPNWKETGMGEVTNQAYRDSGLLSITNSEGL RFLDQIVSKKFGPVVLPAMANQTNWEPELLMKRRKPHEGGLQEAALQSPPARDIEEAD EVSKCDGLLSETQSWLIDLFTEELRIDREDFEIDGLFQDYGVDSIILAQVLQRINRKL EAALDPSILYEYPTIQRFADWLIGSYSERLSALFGGRISDASAPLENKIEAEASVPGK DRALTPQIQAPAILSPDSHAEGIAVVGLSCRFPGAETLESYWSLLSEGRSSIGPIPAE RWGCKTPYYAGVIDGVSYFDPDFFLLHEEDVRAMDPQALLVLEECLKLLYHAGYTPEE IKGKPVGVYIGGRSQHKPDEDSLDHAKNPIVTVGQNYLAANLSQFFDVRGPSVVVDTA CSSALVGMNMAIQALRGGDIQSAIVGGVSLLSSDASHRLFDRRGILSKHSSFHVFDER ADGVVLGEGVGMVMLKTVKQALEDGDIIYAVVKAASVNNDGRTAGPATPNLEAQKEVM KDALFKSGKKPEDISYLEANGSGSIVTDLLELKAIQSVYRSGHSSPLSLGSIKPNIGH PLCAEGIASFIKVVLMLKERRFVPFLSGEKEMAHFDQQKANITFSRALEKWTDSQPTA AINCFADGGTNAHVIVEAWEKDEKHAIKRSPISPPQLKKRMLSPGEPKLEAETSKMTA ANIWDTYEVEV*" gene 1740563..1755694 /gene="pksJ" /locus_tag="BSU_17180" /old_locus_tag="BSU17180" promotor_-10 complement(1745408..1745427) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745424) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1745441..1745450) /Source="Nicolas_upshift_promotors" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1755678..1769294 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16707694, 16757561, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyketide synthase of type I (bacillaene synthesis)" /protein_id="NP_389600.3" /db_xref="EnsemblGenomes-Gn:BSU17190" /db_xref="EnsemblGenomes-Tr:CAB13602" /db_xref="GOA:Q05470" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR011254" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="PDB:5E1V" /db_xref="PDB:5E5N" /db_xref="PDB:5E6K" /db_xref="PDB:5ENY" /db_xref="PDB:5ERF" /db_xref="SubtiList:BG10698" /db_xref="UniProtKB/Swiss-Prot:Q05470" /translation="MRWRSNVKKITKQLTLSLKNPFIYHHVVYGQNVLPGLAYIDIIY QIFREHGFSCSELQLRNLSIYQPLTAEQDAVIVLNIQCAEKKEGQWQITAKGIEKRDG KEASEEKLYMKADMHADSPAIFEETLDLSQIKASAQNVVQLDDVYEQCRRQELVHSEY MKAKGCIYEEEDGVLLELSLGSEAMLHAEGFMFHPTLIDGSGVGANHLLTSLLKGEQR LYLPLFYESFSASALLQTDCMTRIKRSSVRREKELIYVTLEFFNASGEKVAELKNFTS KLVREAELISGKHQDAQETQMTRADTAERDKPADMVSSPVNSYSEAEQFVSQLIAEKI NKPVEQVEKQVGYYQMGLNSSGLLEVVETISDKIGESLSPTLLFEHTTIAELSAFLAE EYAEHFSAAGSLGQNERARVSDSINDHKTVEGSRPAPIEAAGDIAIIGLAGRYPKAAN IHEFWNNLKEGKDCVSEIPESRWDWQRLEGITSPSGKDISKWGGFIDDPDCFDPQFFR ITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNKRQHVGVFAGVMHKDYT LVGAEEASAENVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLALESIR HGECDVALAGGVNLSLHPNKYMTYGVWDMFSTDGHCRTFGKDGDGYVPAEGIGAVLLK PLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPSPVSQADLIETCLEKTGIDPRTISY VEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIGSVKSNIGHAESAAGISGLSKVA LQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQPVIKENGEDVPYPRRAGIS SFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSARNQERLRVYAKRLLDFL HDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAFIEGRKAIQHCWKGRVSR GSEPSRPAESVHKLLEQRKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVR YWVPKAEKKTDRSKQERHILHPLLHQNVSDISGVRFRSAFTGREFFLKDHVIKGEHVL PGAALLEMVRAAVERAAADQFPTGFRLRNIVWVRPFAVTEQQKDIDVRLYPEENGEIT FEICRDPESAEESPIVYGQGSAVLCEAGENPVINIEELKASYNGRTLSPFDCYEAYTE MGIHYGDSHRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRL GGATSLEDRKAMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEG QVCVRLTSYSARVLETDQEGPSEANDTLLFEHIWEERAAERQELIEYDTYKVVVCDVG EQMESLQNHLDCTVLQHDTETIDERFEGYAIQLFEEIKQLMHSKTGGHTFIQVAVPAL DEPQLLSGLTGLLKTAELENPKLTGQLIEIETGMSAGELFEILEENRRYPRDTHIRHW QGKRFVSKWKEVSGEHLSADMPWKDKGVYLITGGAGGLGFIFATEIANQTNDAVVILT GRSPLDERKKKKLKALQKLGIQAIYRQADLADKQTVDALLKETQNVYGDLDGIIHSAG LIKDNFIMKKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQAD YAMANAFMNAFSEYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMV AMETDRGIQALYHGWTSGKPQVLVASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEA EKADMIGEIDEEILREKAENYFKQVLSSVIKLPAGQIDAEAPLEDYGIDSIMIMHVTG QLEKVFGSLSKTLFFEYQDIRSLTRYFIDSRREKLLDILGFETGKPSVERKSEPEKQE IPVIPRKSGFLPLQDKEQKQVREKETEEIAIIGISGRYPQADNIDELWEKLRDGRDCI TEIPADRWDHSLYYDEDKDKPGKTYSKWGGFMKDVDKFDPQFFHISPREAKLMDPQER LFLQCVYETMEDAGYTREHLGRKRDAELGGSVGVYVGVMYEEYQLYGAQEQVRGRSLA LTGNPSSIANRVSYYFDFHGPSIALDTMCSSSLTAIHLACQSLQRGECEAAFAGGVNV SIHPNKYLMLGQNKFMSSKGRCESFGQGGDGYVPGEGVGAVLLKPLSKAVEDGDHIYG IIKGTAINHGGKTNGYSVPNPNAQADVIKKAFVEAKVDPRTVSYIEAHGTGTSLGDPI EITGLSKVFTQETDDKQFCAIGSAKSNIGHCESAAGIAGVTKVLLQMKYRQLAPSLHS NVLNPNIDFLNSPFKVQQELEEWKRPIISVNGKDIELPRIAGVSSFGAGGVNAHILIE EYAPEPVEERLPARKQPAVIVLSAKNEERLQKRAERLLHAIREQTYVEADLHRIAYTL QVGREAMKERLAFVAETMQELEEKLYECISGTENREYVYRGQVKSNKEAIAAFAADED MSKTIEAWLQKGKYAKVLDLWVRGLRIDWSTLYQDQKPRRISLPAYPFARDRYWIDVN AKAEEKRTEEPFAPVQPVIPKPSVDREASGKPANITLQPLMTNQDRLERVPSDTETET ITAEALCDELTAGLAEVLYMDQNEIDPDEAFIDIGMDSITGLEWIKAINKQYGTSLNV TKVYDYPTTRDFAVYLAHELSTQAGEKKQTETYTPIRQKTVVPAAKPANISLQPLEHH QPVQEEAEETIQYAAAEISASRQYTVAIETLHENLRESIADVLYMEPYEVDIDEAFID IGMDSITGLEWIKAVNKQYGTSFTVTRVYDYPTIRDFAEMLKSELGTHLDRKIEHTDS FEAAQQKPAASSHPKPAERPLQPVQHPIKKEHEKKTVPVLQDRPEDAIAIVGMSGRYP GARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMGMLDDIEHFD PLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLGIMSNEYGVM LNRQSRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLARQALINKEID MALVGGVSLYLTPESYMSMCEAGMLSPDGQCKAFDNGANGFVPGEGAGALVLKRLKDA EADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISYVEMHG TGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLCMNH KTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIVI EEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQ TGREAMDYRMAFLADSREMLIKALDDYLAEMPNGSIFAAHVKTKKSEIKLFETDHDAK ALLQTWIEKKRLEKVAELWVKGLQIDWNKLYGEYTPRRISLPAYPFAEEYYWLPTQEG EPETIATAMPQFELMPKRCFLRKQWQPCPIEPAEMTNQTVAILANEETMALAEELSAY FSTYRIFDSQELDRVSAADYEHVAGAIDLIGCGTSHEHSMGWINWLQKLIEQGRASKH HLTVLGVTKGLEAYANEGVLLSGASRAGLYRMLQSEYSHLTSRHADMECEASHEELAR LIAVEYYAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGL GLLCARHFVKTYGVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQV LSLDLTDRVAVEQSLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKV EGLQTLFDLLQDEPLAFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQDKCPI VSIQWPNWKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTN VWKPDKLMQPSLPVEALSHPETKEQTSTRNLFPETVDWLVTLFSDELKIAAEDFETDE PFQEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISAVLQPS VPEKQTPLKPQSAMKQKLVPEQRPQQISHEKTALLAEDIAIIGLSCRFPGAETLEEYW DLIRDGRSAIAPVPPERFGNSSSNYAGLIDEMNRFDHDFFMMSESDVRAMDPQALAVL EESLKLWYHAGYTEKEVKGMRAGVYIGGRSQHKPDPASLSKAKNPIVAGGQNYLAANI SQFFDLKGPSIVLDTACSSALVGLNMAIQALRSGDIEAAVVGGVSLLDADAHRMFHER GLLCDKPSFHIFDKRADGVILGEGVGMVLVKTVNQAVEDGDSIYAVIKAAAINNDGRT AGPSSPNLEAQKDVMLSALEKSGKKTEEISYLEANGSGSAVTDLLELKAIQSIYRSES KAPLGLGSVKPNIGHPLCAEGIASLIKVALMLKHRQLVPFLSGNENMPYFDIEKTDLY FSRSQAEWKETTPAAAINCFADGGTNAHLIIEGWRDSAERPIRRKPLPLPELNRQPVL IKPSAQNVQKKVHSDTGASKDMFWKTFK*" gene 1755678..1769294 /gene="pksL" /locus_tag="BSU_17190" /old_locus_tag="BSU17190" CDS 1769310..1782098 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15480790, 16707694, 17234808, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15480790, 16707694, 17234808, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389601.3" /db_xref="EnsemblGenomes-Gn:BSU17200" /db_xref="EnsemblGenomes-Tr:CAB13603" /db_xref="GOA:P40872" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10931" /db_xref="UniProtKB/Swiss-Prot:P40872" /translation="MITEQLHISLNNPIMSNHKVYGQALLPGLAYIDLIYQVFQEHGY AYQELELKNLTIFYPLIADESYDIALTIHVSERKEGTWSIIIDGQKQHGESLSDKRQY VTADMHRKEQTAFAESIDLNQWKSTADRILNLDEIYEQCRSQELVHTGMMKAEGQIYE AKEGAVIDLAVGQEALRHSDAFLFHPTLIDGSGIGSSCLISDQTMYLPLYYESFSASE RLQKGCTARILSSSVRQKKELTYMTIEYFNSAGQKVAELKQFAGKSVRNMSAFHSAKE IQEERAAVSQNISRDYPAFEMYLRQLLAKQLERPAEQMDIHAGYYELGLDSSSLLTVV QEIGDKVGADLAPTLLFEFTTIAELAAHLADHYSIGEADDAVRQSPSPIDGVTSSPEI GEDIAIIGMAGRYPKAKNIQEFWEQLKAGTDCITEIPNSRWEWKESDGLDSPAGKPLS KWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWEAIEDAGYTPETIASPQGE NKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNYAQIANRVSYYCNFHGPSMAVD TVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYCHTFG KGGDGYVSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQAD VIEACLEKTGIDPRTISYVEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKS NIGHAEAAAGISGLTKTVLQLHHKTLVPSLHSEELNPYLKLDQTPFFVQHETKEWEQP SFTENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSETILTKNEEIVIPLSAR NKDRLQAYALKLLDFLSEDVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKLRAFA NGEEEIEGCWTGRAKENQEAAGLASVNALNNNLIRDSEMMEMAKAWVQGKRVTWDDLY GDRKPLKISVPTYPFARERYWISVPEMKTSTVNHILHPLVHRNTSDFTEQRFSSVFTG TEFFLSDHVVQGQKILPGVAYLEMAREAAEKAAGDLDGEQRVVSLKDIVWVRPITIES EPKEIHIGLFPEDNGDISFDIYSSSEHKEEALTIHCQGRAVISDEAETSILNLSSIQT ECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVGKDQLLAKISLPAFLKNDKQHFA LHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQEVDIFSPCPEKIWSYIRYSSD SKAENKVRKYDIDLCDENGRVCVRMKGASMRALDGEQHSKPQLLTDSQLTGHTVMIPV WEPVSLEAEDNASFAGKRAVLCGAAEADRTFIKHHYPQISFVDIRPADDIEAIADKLQ AYGSIDHVLWIAPSHRGSIGSDGQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQ PVTQHEAVQPAHASIHGLAGTMAKEYPHWKIRLLDLEKGCTWPVNHMFALPADRLGHA WAYRNQQWHQQQLIPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWSEYMIRRYQAQIV WIGRSQLNAAIQSKIDRLSALGPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHS AMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQ SHYASGCTFADAFAHQLSQSWACPVKVMNWGYWGNSEAAEDEHYVQLMNQIGLGLIEP AEAMKALEALLSGPVSQTAFIHTTKPVAVEGVNQNEFITLYPEQPSADAESLMERLPT TGRFQRVTHEELDDLLYRLLLGQLQTAELFDGYTLSVERLQQYKTREFYGKWIRQSSE FLLQHGYLKKVGDSLVRKDQAEDIELLWLEWNAKKEKWLKDSETKAMVVLAEAMLQAL PDILTGKVPATDIMFPHSSMELVEGIYKHNQVADYFNKVLADTLLAYLDERLKHDPEA SIRIMEIGAGTGGTSAGIFEKLKPYQKHINEYCYTDLSKAFLLHAEKEYGAENPYLTY QLFDVEKPIDQQEFEAGGYDVVIAANVLHATKNIRQTLRHTKAVMKNNGMLLLNEMAG NSLFPHITFGLLEGWWLYEDPAVRIPGCPGLHPDSWKAALESEGFESVFFPAEAAHDL SHQIVAASSNGLVRRMMKNVILPEKVVSQASNQEPAYIHTIDSEEAGQSKHALLREKS TEYMKKLIGETLKIPAGKIESSEPLEKYGIDSIVVVQLTNTLRKEFDHVSSTLFFEYQ TIDALVEHFIKTKTEALMKLTGLDRQVQQHTPAESRTQSSQKPDQAAKRTRRFRKLGF SGEKETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDWKAY YDKEKGKEGSIYTKWGGFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYASIEDA GYTPDSLCSSRKIGVFAGVMNKNYPTGYGYWSIANRISYLLNFQGPSLAVDTACSSSL TAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNMLSASDTCKSFGDDADGFV DGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHAQAQVIKEAIE RADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSKSNIGHCES AAGIAGLTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPVIGGQEV PRRAGLSSFGAGGSNAHIILEEYIPRTGAQTPKDHPPALIVLSAKNMERLQEKAEQLL TAIKQKRYCETDLIRIAYTLQTGREAMEERLAFIAESLEDLERKLNDFIENKADSLYL DRIDDNKKALAVLSADEDTEKIIEAWMSKGKYTKLLDLWVKGLSFDWGMLYGTQTPVR ISLPAYPFAKERYWAPGAAKAPVSIEQDHDQQTEEPFKVMTFQEVWKEEPATLTSKRI KTLICFLTEREKQNAFASALKNVDQDTKVIFISQGEVYSKQSEYSYQIVRQEPVTFEK AFQSIKEELGEPDAILYMWPMEDKRCIKDHSCIVYLLQGMSAAKLHPSRLLLAGCFED SLDRSYLESWIGFERSLGLVLPHTKVTGIFQPAEQGSMDDWTRKVWAELQASTEQTVL YQNLKRYVNHIEQTTIQPDNSKLKSGGTYLITGGVGGLGYLFAKHLAKNYAANLILTG RSPFNDEKQKQIKELKDLGGEAMYAEADVSDPIAMGDCVKRGKDRFGAINGVIHAAGI ESDSAIFDKKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCCDY AIGNRFQMAYAQYRNELHNGKTFVINWPVWKDGGMKIGDEETTDMYLKSSGQRFLEAE EGIRMFEHILAQQDAQHLVIAGQPSRVSRFLGMTEPAIPEPATQAPLAQENKDEVKTL SIEKRLEHDLKEHIHTLLKISKDKLNLNKNWADFGFDSIYLAKFSNVLSKHFNIEVTP ALFFGYSTLQELISFFLTDHKELIEAFYRDDASEAQKPPEAYAVIPVALEPEASKKSI RQVHDEPIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERRDWGRANRDPEKAV PRWGAFLKDIDRFDPLFFQISPKEAESMDPRQRIFLEEAWHTFEDAGYMGDRIKGKSC GVYVGVEEGEYAHLTGDTDYINGTQNATLSARIAYALDLKGPNMALTAACSSGLVAIH QACSALRQGDCEMALAGGVSLNISHMSFEALTRAEMLSPNGQCKVFDQDANGLVPGEA VAAVLLKPLSKAIEDKDHIYGCIKASGVNYDGKTNGITAPNPFSQAELIENIYEKNEI NPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQKQFCMISSIKPLIGHTFAASGT VALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLCKENRSWIKKNQKPRMGTIST TGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQNDDRLQDAACRMIAYLEQNH NLSLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKEYVEAMKNGGVSGQQRSLYTG YTEGILEEQDEAVLQALAKERNLENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFA RERYWISSGTQQSEAVKQHSQDMKTEIDEPNGKTHIQKIIVQFLARELGISEDRINFK RNFLDYGMDSILGRKLMRHIEKTTQLKMAGREILECQTVQALSDHLALKAEKQNHSAA AHHIKGTYTDEQIIGLMQEVALGKLDFKSVQNIIEGSKSYES*" gene 1769310..1782098 /gene="pksM" /locus_tag="BSU_17200" /old_locus_tag="BSU17200" CDS 1782166..1798632 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16460000, 16707694, 17234808, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase of type I involved in bacillaene synthesis" /protein_id="NP_389602.3" /db_xref="EnsemblGenomes-Gn:BSU17210" /db_xref="EnsemblGenomes-Tr:CAB13604" /db_xref="GOA:O31782" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG12652" /db_xref="UniProtKB/Swiss-Prot:O31782" /translation="MKRQLKSPLSEGQKGLWMLQKMSPGMSAYNIPLCFRFSKPIHAE TFKKALLFVQRQYPVLASVIQEENGIPFQSVQLSKDLYFVEEDISAMKSADIMPFLKE KAKEPFQLEAGPLWRTHLFHRLEECIVLITIHHIIFDGVSMLTLISALFEAYQQLLNG IEPLQQPSTADYYDFVDWENRMLTGREGEEHLAYWKEQLSGSLPVLDLPADRPRSSAR KFKGQAYKSLLPHHLRNQIKSFARTNHVNESVVFLSIYKVLLHHYTKQKDIIVGVPTM GRQEDRFETLIGYFINMMAVRSKNIGSQPLTAFIRELQLTVAVGLDHAAFPFPALVRE LNVDRSAADSPVFQTAFLYQNFFQATGLQKVLEPYQTLGIEYIEDIRQEGEFELALEI YEQENETVLHLLYNPDLYELSSIESMMENYMKLAQHMMEDPSLPLEAYSLQLNQEQTS LLEQWNATGTNIANDKCIHEVFEEKAKQTPDAVAVMFEDRSLTYKEVDEKSTSVAVYL QHQGVRPEQPVGICAERSFDMIIGILGILKAGGAYVPLDPSFPQERLKYMLKDSQASI VLTQPNVHDRISGLTGSHVKAINIELACRNGYTDQQSSGLKREVKPEHLAYIIYTSGS TGEPKGVMVEHRSIMNTLNFLESHYPVTAEDAYLLKTNYVFDVSISELFGWFIGDGRL VILPPNGEKSPQLCMDYIETYKVTHINFVPAMLHVFLEMAKDNKRFTEDGPLKYMMVA GEAFPKVLVKKAVSLFTNCRVENIYGPTEASIYAAYFGCGKGDIASHHTPIGKPVSNT KIYIVDQHLKPVPIGKPGELCIAGAGLARGYFKKPGLTAEKFIDNPFESGTKLYKSGD SARWLPDGNIEYLGRIDSQVKIRGFRVELGAIETKLGEFPGILDQAVVVKQLEGHQQL AAYYTEESGHASANPKDLRLHLKSSLPEYMIPSHFIRLDELPLSPSGKVNRKELEKRE IVFNRRKPNHLQLTEIEDQVLRIWEETLKVSGFGPEDGFFDAGGDSLLAVAVAERIKK EFDCEFHVTELFEYSTIRAISEYILEMKNSDLAGTQNEDDHDDKKDGKYPKQKIPPYF DDSVAIVGISCQFPGAKNHHDFWNHIKEGKESIRFFSEEELRANGVPEELIQHPDYVP VQSVIEGKDLFDPGFFQISPKDAEYMDPQLRLLLLHSWKAIEDAGYVAKEIPATSVYM SASSNSYRTLLPKETTEGHESPDGYVSWVLAQSGTIPTMISHKLGLKGPSYFVHSNCS SSLVGLYQAYKSLTSGESQYALVGGATLHAQSAIGYVHQNGLNFSSDGHVKAFDASAD GMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGIGINNDGAEKAGFYAPSVKGQTEVIQ HVLDTTKIHPETVSYIEAHGTGTKLGDPIEMSALNKVYKQYTDKTQFCGIGSVKTNIG HLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPDIKFESSPFYVVRERKSLEKHAGV HRAALSSFGLGGTNAHAIFEQYENISDAGAENEGNQPYIIPISAKNSERLQVYAKEML SYISQDEQRHFSLRDIAYTFQVGREAMDNRIVFIVNDLEEWKHQLEAFVTGKPLAEGC IQGEKTRMTSAEQLLGNAEADDMASSRISKEELRKLAEMWANGFHVEWRRLYPNIKPR RISLPTYPFAEERYWPESSTGAITTIEPSRLHPLVHHNTSVLSEQRFSSIFTGQEYFI AEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKNVVWVRPVVAGSEPVQV NIGLYDEDGGHIAYRMYGDPESADAEPVVYNQGKAELIQLKREKALDLSKIKKQCDQS KMDAASFYEGMIGADYGPGYKSVEAVYKGDGQLLAKLSLPESVAHTLGDYVLHPSVMD GALQAAEYLQNVVRAELSDTEDFKAALPFALEELEVFRQCVSDMWVYVQFNSKNKPGD LIQKVDIHLCDEHGMICVRLKGFSTRVMEADIQTEPSKINAETLLLQPVWQEQKAANS LAAKKYAEHLVFLCEYDHETRKQIEAAIEDVHVYSLEARPSSVDGRFHSYTEQVFKKV QEIIRTKPKDGILVQIVTSAEGEQQLFSGLTGLLKTACQENAKLTGQMIEVSSEESGE SIAGKLLENQMSSDSYVKYQNGTRYIADWREIKQAKGDGSKPWKDNGVYLISGGAGGL GHIFAKEIAEQTKNATVILAGRSPLSESKSKKLKELHSKGADITYRQTDVTNKIEVYQ LIDDIQKRYGRLNGILHSAGIIKDSYLVNKQAKDLHDVLAPKVKGLVYLDEASKDLPL DFFILFSSLSGSLGSIGQSDYAAANVFMDMYAGYRNRLADLSQRHGQTLSVNWPLWRD GGMQVDQETEKRLVQLAGIVPMRAEKGIQALYQALHSEANQVMVIEGDVQKIKQNMLA KNASAPMEKKEAEHMTEQINSIDADSLLDKVKAMLKREIAKLLKVKLETIDDHAEMTV YGFDSISMTEFTNHINRAYQLELTPTVFFDHPTIHAFGKHLSEEYQSVFAKTFAVRAV SAQLQPAAKQEQAVRAKAKRRRKQQVMLPNAIQSDAGPEPIAIVGISGIFPMAKDVEA YWNILKEGKDCMTEIPKDRWDWREYEGDPAKEVNKTNVKWGGFIDGIADFDPLFFGIS PREAEQMEPQQRLLLTYAWKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSA IEGSAAANTSPSVGPNRVSYFLNLHGPSEPVDTACSSSLVAIHHAISSIEEGTCDMAL AGGVNTIILPEVYISFDKAGALSKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEA GDHIYGVIKGSAINHGGRAASLTTPNPKAQADVIQSAYQKAGIDPKTVTYIEAHGTGT ELGDPVEINGLKSAFKALGVNEGDTSANPYCGLGSVKTNIGHLSLAAGAAGVIKILLQ LKHKTLVKSLHCENVNPYIQLKNSPFYIVRETEEWKALKNEQGEELPRRAGVSSFGIG GVNAHVIIEEYIPEASDENIPSIAPEHPGIFVLSAKNEARLKEHAQQLADALDKQTYS DVNLARIAYTLQAGRDAMEERLGIISGSIEDLQKKLKDFAAEKSGVEDVFKGRIDKGT LQMLTEDEEIQEAVEKWMERGKYAKLLELWVKGLDVDWTKLYGENLPKRISLPTYPFA KDRYWISDHIEKSGSIDANQAASRLGGAVLHPLMHQNTSNLSEQRFSSIYTGEEFFLA DHVVKGQRILPGVAHLELARAAVEQAAEVQGVPRIMKLKNAVWVRPIVVEDQPQQVHI RLLPGENGEISYEIYGHSDVTGEQSIVYSQGSAVLNPAENLPAVDLQSLREQCQESHF SVNEVYDTYRMIGFEYGPAYRGVKKIYTAEQFVLAKLSLHPSAADTLSQYKMHPGLMD SALQASSILTGAGDNQLTLPFAVQELEVFGACSSEMWVYARYSQGSKATDKVQKRDMD ILDESGNVCVRMKGLSFRAAEGGSGSAESDQTLATLMFEEKWVPKDFKKESPEPHYER HIVMLCDMNGLSKDRIESRMTGAECIVLESFREGLAERFQDYAEQALETVQGLLKSRP QGNVLIQLLTSAQRKQYSFSGLSALLKTAGLENKKLIGQTIEIDSHENVESVIEKLKE NKRHTEDQHIKYEKGKRYINDLDEMQIDDREISMPWRDKGVYLITGGAGGLGFIFAKE IARQAEQPVLILTGRSALNADQQAELNELQQLGARAEYRQVDVTQTEAASELITSITS DYEDLNGVIHSAGLIKDNYLMSKTNEELTQVLAPKVKGLVNVDEATEHLALDFFILFS SISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKEGGMRANK EIENMTLKNTGVTPMRTETGIQALYKGLAFGKDQVIVMEGFKDMMREKLTQKPSSDDV PMKTVQVRVTSEARMDQGNMFDHIQEVLKQTISQLLKIKPEEIDPDMEFNQYGFDSIT LTEFANTLNEKCKLDLTPTVFFEHATVYAFAGYLSEEYPNAFTAQTPAKAEVLMQPVE QNIKNMTFSTENRFVKPSVTPMQKEADHKPEPIAIVGMSGVFPKAKDVEEYWKNLSSG ADCITEVPKDRWDWQEYYGDPLKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQME PQQRLLMTYAWKAVEEAGHSARSLAGTKTGIFIGTGNTGYSSLLSNVDIEGSAAANMS PSAGPNRVSYFLNIHGPSEPIDTACSSSLVAIHHAVCAIENGNCEMAIAGGVNTVVTP QGHIAYDKAGALSKEGRCKTFSDKADGFAVSEGAGILFLKKLTAAERDGDHIYGVIKG SAVNHGGRANSLTTPNPKAQADVVKTAYEKAGIDPRTVTYIEAHGTGTELGDPVEING LKAAFKELYEKTGDPAVHGSHCGLGSAKTNIGHLSLAAGVAGVIKVLLQLKHKTLVKS LYSETVNPYIRLDDSPFYIVQESREWQALRDEAGRELPRRAGISSFGIGGVNAHVVIE EYIPKETTHPATAPAVTAQHPGIFILSAKDEDRLKDQARQLADFISKRSITARDLTDI AYTLQEGRDAMEERLGIIAVSTGDLLEKLNLFIEGGTNAKYMYRGRAEKGIAQTLRSD DEVQKTLNNSWEPHIYERLLDLWVKGMEIGWSKLYDGKQPKRISLPTYPFAKERYWIT DTKEEAAAHQTALKTVESAALHPLIHVNTSDLSEQRFSSAFTGAEFFFADHKVKGKPV MPGVAYLEMVHAAVTRAVRRTEDQQSVIHIKNVVWVQPIVADGQPVQVDISLNPQQDG EIAFNVYTEAAHNDRKIHCQGSASIRGAGDIPVQDISALQDQCSLSTLSHDQCYELFK AIGIDYGPGFQGIDRLYIGRNQALAELSLPAGVTHTLNEFVLHPSMADSALQASIGLK LNSGDEQLSLPFALQELEIFSPCTNKMWVSVTSRPNEDKIQRLDIDLCDEQGRVCVRI KGITSRLLEEGIQPPDGPTSLGNSKATLNGALLMAPIWDRVQLEKRSISPADERVVIL GGDDNSRKAVQREFPFAKELYIEPNASIHRITGQLEALGSFDHIVWMSPSRVTECEVG DEMIEAQDQGVIQMYRLIKAMLSLGYGQKEISWTIVTVNTQYVDQHDIVDPVDAGVHG LIGSMSKEYPNWQTKLIDVKKYEDLPLSQLLSLPADQEGNTWAYRNKIWHKLRLIPVH NNQPVHTKYKHGGVYVVIGGAGGIGEAWSEYMIRTYQAQIVWIGRRKKDAAIQSKLDR FARLGRAPYYIQADAANREELERAYETMKQTHREINGIIHSAIVLQDRSLMNMSEECF RNVLAAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAAGCSFKDAFAQRL SQVWPCTVAVMNWSYWGSIGVVSSPDYQKRMAQAGIGSIEAPEAMEALELLLGGPLKQ LVMMKMANETNDEAEQTEETIEVYPETHGSAIQKLRSYHPGDNTKIQQLL*" gene 1782166..1798632 /gene="pksN" /locus_tag="BSU_17210" /old_locus_tag="BSU17210" CDS 1798647..1806278 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10960106, 15480790, 16707694, 17234808, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trans AT polyketide synthase involved in nonribosomal synthesis of bacillaene" /protein_id="NP_389604.2" /db_xref="EnsemblGenomes-Gn:BSU17220" /db_xref="EnsemblGenomes-Tr:CAB13606" /db_xref="GOA:O31784" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR013217" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036736" /db_xref="PDB:4U3V" /db_xref="SubtiList:BG12654" /db_xref="UniProtKB/Swiss-Prot:O31784" /translation="MLNTEDILCKMLFAQLQSIGFFTESKSQPVLENFYGRWFEESQS ILERHQFLKRTENGHVPTRSIGTMSELWKEWNEQKFDLLQDNNMKAMVTLVETALKAL PEILTGKASATDILFPNSSMDLVEGVYKNNQVADYFNDVLADTLTAYLQERLKQEPEA KIRILEIGAGTGGTSAAVFQKLKAWQTHIKEYCYTDLSKAFLMHAENKYGPDNPYLTY KRFNVEEPASEQHIDAGGYDAVIAANVLHATKNIRQTLRNAKAVLKKNGLLLLNEISN HNIYSHLTFGLLEGWWLYEDPDLRIPGCPGLYPDTWKMVLESEGFRYVSFMAEQSHQL GQQIIAAESNGVVRQKKRTEAEEDPSHIQMNAEIDHSQESDSLIEQTAQFVKHTLAKS IKLSPERIHEDTTFEKYGIDSILQVNFIRELEKVTGELPKTILFEHNNTKELVEYLVK GHENKLRTALLKEKTKPAKNEAPLQTERTDPNKPFTFHTRRFVTEQEVTETQLANTEP LKIEKTSNLQGTHFNDSSTEDIAIIGVSGRYPMSNSLEELWGHLIAGDNCITEAPESR WRTSLLKTLSKDPKKPANKKRYGGFLQDIEAFDHQLFEVEQNRVMEMTPELRLCLETV WETFEDGGYTRTRLDKLRDDDGVGVFIGNMYNQYFWNIPSLEQAVLSSNGGDWHIANR VSHFFNLTGPSIAVSSACSSSLNAIHLACESLKLKNCSMAIAGGVNLTLDLSKYDSLE RANLLGSGNQSKSFGTGNGLIPGEGVGAVLLKPLSKAMEDQDHIYAVIKSSFANHSGG RQMYTAPDPKQQAKLIVKSIQQSGIDPETIGYIESAANGSALGDPIEVIALTNAFQQY TNKKQFCAIGSVKSNLGHLEAASGISQLTKVLLQMKKGTLVPTINAMPVNPNIKLEHT AFYLQEQTEPWHRLNDPETGKQLPRRSMINSFGAGGAYANLIIEEYMETAPEKEHIAP RQQEFTAVFSAKTKWSLLSYLENMQLFLEKEASLDIEPVVQALHRRNHNLEHRTAFTV ASTQELIEKLKVFRTSRESSLQQGIYTSFDLQPCAESASRDREINAAEQWAQGALIAF KEADIGNRTGWVHLPHYAFDHNTSFHFDVSSINEKSSDVEDNINQPVIQDQFTYDEPY VQGHVFNNERVLVGATYGSLAIEAFFNLFPEENSGRISKLSYISPIVIKQGETIELQA KPLQKDQVIELQIMYREPSSGLWKPAAIGQCGIGSFEPKKVNIENVKHSLTKLHHIDQ MYKTGNGPEWGELFKTITHLYRDHKSILAKIRLPQSGLANGHHYTVSPLMTNSAYLAI LSFLEQFDMTGGFLPFGINDIQFTKQTIKGDCWLLITLVKNTGDMLLFDVDVINESSE TVLHYSGYSLKQLRISNQRGNQNKAIKASNLKARIRSYVTDKLAVNMADPSKLSIAKA HIMDFGIDSSQLVALTREMEAETKIELNPTLFFEYPTIQELIDFFADKHEASFAQLFG EAHQQEERPAQIENQMKQIPAYETNTDKTIEHAADGIAIIGMSGQFPKANSVTEFWDN LVQGKNCVSEVPKERWDWRKYAAADKEGQSSLQWGGFIEGIGEFDPLFFGISPKEAAN MDPQEFLLLIHAWKAMEDAGLTGQVLSSRPTGVFVAAGNTDTAVVPSLIPNRISYALD VKGPSEYYEAACSSALVALHRAIQSIRNGECEQAIVGAVNLLLSPKGFIGFDSMGYLS EKGQAKSFQADANGFVRSEGAGVLIIKPLQKAIEDSDHIYSVIKGSGVSHGGRGMSLH APNPAGMKDAMLKAYQGAQIDPKTVTYIEAHGIASPLADAIEIEALKSGCSQLELELP QEVREEAPCYISSLKPSIGHGELVSGMAALMKVSMAMKHQTIPGISGFSSLNDQVSLK GTRFRVTAENQQWRDLSDDAGKKIPRRASINSYSFGGVNAHVILEEYIPLPKPPVSMS ENGAHIVVLSAKNQDRLKAIAQQQLDYVNKQQELSLQDYAYTLQTGREEMEDRLALVV RSKEELVIGLQACLAEKGDKLKSSVPVFSGNAENGSSDLEALLDGPLREMVIETLLSE NNLEKIAFCWTKGVQIPWEKLYQGKGARRIPLPTYPFEKRSCWNGFQAVENTPSVSQD ERINNSSDHHILANVLGMAPDELQFHKPLQQYGFDSISCIQLLQQLQSKVDPLIVLTE LQACHTVQDMMDLIAKKQEDTSLQNDQARTFPELIPLNDGKRGRPVFWFHGGVGGVEI YQQFAQKSQRPFYGIQARGFMTDSAPLHGIEQMASYYIEIIRSIQPEGPYDVGGYSLG GMIAYEVTRQLQSQGLAVKSMVMIDSPYRSETKENEASMKTSMLQTINTMLASIAKRE KFTDVLISREEVDISLEDEEFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLE SYTVKPLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHF HLVDVDSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETD ELVKR*" gene 1798647..1806278 /gene="pksR" /locus_tag="BSU_17220" /old_locus_tag="BSU17220" downshifts 1806267 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" CDS complement(1806323..1807540) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" gene complement(1806323..1807540) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" downshifts complement(1806342) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(1807555..1807655) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1807595) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" promotor_-10 complement(1807627..1807646) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807639) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" S_feature complement(1807641..1807721) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1807661..1807668) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1807765) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" CDS complement(1807771..1808127) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" gene complement(1807771..1808127) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" misc_feature complement(1808187..1808200) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1808192) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" CDS complement(1808206..1809030) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" gene complement(1808206..1809030) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" promotor_-10 complement(1809052..1809071) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1809068) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" promotor_-35 complement(1809083..1809089) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1809141..1810469) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" gene complement(1809141..1810469) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" downshifts complement(1809148) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" promotor_-10 complement(1810492..1810511) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810511) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" promotor_-35 complement(1810525..1810533) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1810626..1810633 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1810641..1810660) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1810649..1810668 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810652) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" upshifts 1810655 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" promotor_-35 complement(1810673..1810680) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1810694..1810771 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" gene 1810694..1810771 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo downshifts complement(1810696) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" CDS 1810749..1810925 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" gene 1810749..1810925 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo downshifts 1810906 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" S_feature 1810951..1811139 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1811134..1811153 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1811141 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" CDS 1811205..1811912 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" gene 1811205..1811912 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" promotor_-35 1811923..1811929 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1811943..1811962 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1811947 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" CDS 1811982..1812434 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" gene 1811982..1812434 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" downshifts 1812422 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" CDS complement(1812448..1812801) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" gene complement(1812448..1812801) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" downshifts complement(1812489) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" CDS complement(1812815..1813132) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" gene complement(1812815..1813132) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" promotor_-10 complement(1813176..1813195) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813184) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" promotor_-35 complement(1813210..1813217) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813269..1813544) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" gene complement(1813269..1813544) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" downshifts complement(1813270) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" promotor_-35 1813540..1813545 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1813561..1813579 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1813571..1813590) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1813581 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" upshifts complement(1813584) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" promotor_-35 complement(1813603..1813612) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1813633..1814046 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" gene 1813633..1814046 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" upshifts 1814097 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" misc_feature 1814103..1814122 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1814146..1815090 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" gene 1814146..1815090 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" promotor_-35 1815070..1815078 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1815089..1815107 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1815091 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" CDS 1815130..1815351 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" gene 1815130..1815351 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" downshifts complement(1815141) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" promotor_-10 complement(1815203..1815207) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815207) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1815222..1815227) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1815351 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" CDS 1815547..1815819 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" gene 1815547..1815819 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" promotor_-35 1815835..1815842 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1815856..1815875 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1815858 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" CDS 1815901..1816131 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" gene 1815901..1816131 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" S_feature 1816132..1816208 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1816165 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" S_feature 1816210..1816317 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1816290..1816297 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1816311..1816330 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1816319 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" CDS 1816374..1816766 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" gene 1816374..1816766 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" CDS 1816726..1818828 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" gene 1816726..1818828 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" CDS 1818846..1819835 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" gene 1818846..1819835 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" downshifts 1819795 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" S_feature complement(1819849..1820508) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1819864) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" CDS 1819885..1820505 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" gene 1819885..1820505 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" downshifts 1820486 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" promotor_-35 1820521..1820525 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1820543..1820910 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1820543 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" promotor_-10 1820547..1820564 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1820553) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" CDS complement(1820569..1821336) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" gene complement(1820569..1821336) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" promotor_-10 complement(1821345..1821364) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821368) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" promotor_-35 complement(1821377..1821386) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1821490..1821495 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1821511..1821529 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1821511 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1821793..1821798 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1821815..1821833 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1821819..1821959 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1821819 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" CDS 1821960..1822928 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" gene 1821960..1822928 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" downshifts 1822897 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" promotor_-35 1822992..1823000 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1823007 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" promotor_-10 1823011..1823030 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1823061..1824323 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" gene 1823061..1824323 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" CDS 1824341..1825606 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" gene 1824341..1825606 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" promotor_-35 1825654..1825661 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1825676..1825695 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1825688 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1825716..1826123 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" gene 1825716..1826123 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" downshifts complement(1825722) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" misc_feature 1826104..1826122 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1826129 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" downshifts complement(1826182) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" CDS 1826182..1827516 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" gene 1826182..1827516 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" downshifts 1827493 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" S_feature 1827538..1827798 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" promotor_-35 1827773..1827780 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1827795..1827814 /Source="Nicolas_upshift_promotors" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1827800 /Source="Nicolas_upshifts" /id="U1396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig="0.997002997002997" /xcortree=3171 /SigmaFactorBS="agcaataataagatgagtaaggtagatgtttatCATTGACAt cataaccaaatgaATCCATAATTACGTTGAAATctaaatcaattttcaaaaaggagat t" /listShort="ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" CDS 1827844..1828134 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective, phage region" /protein_id="NP_389629.1" /db_xref="EnsemblGenomes-Gn:BSU17470" /db_xref="EnsemblGenomes-Tr:CAB13631" /db_xref="GOA:P31844" /db_xref="SubtiList:BG11074" /db_xref="UniProtKB/Swiss-Prot:P31844" /translation="MKKLTIFSGGLGAVFSVLAQLFAVIDDSYTLGNLWFLGALAGII TMLASIQTNNKPVFSILLIASSVIGLLGTGLVYIIPTLFNIIIIYKFSKVSQ*" gene 1827844..1828134 /gene="ynxB" /locus_tag="BSU_17470" /old_locus_tag="BSU17470" S_feature 1828135..1828379 /Source="Nicolas_S_feature" /locus_tag="new_1880378_1880622" /HighExp="Cold, M9-stat, BC, B60, LPhT, T0.30H, LBGstat, LoTm, S4, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49198399999999998" /TUshortSig="SigA, SigL, SigA" /TUshortPSig="0.997, 0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S626" CDS 1828380..1828724 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389630.1" /db_xref="EnsemblGenomes-Gn:BSU17480" /db_xref="EnsemblGenomes-Tr:CAB13632" /db_xref="SubtiList:BG13469" /db_xref="UniProtKB/Swiss-Prot:O31799" /translation="MWKALSQLLKKQKNQSPSDEDYIQIPELEVKVLGMLHSINIDLV NVIAQAEKSKEFIGQIEGIWHSIANQFYSLAQGFENEDINKLSADLDHAAATWEAVAN KAKEFVTNSYQG*" gene 1828380..1828724 /gene="ynzF" /locus_tag="BSU_17480" /old_locus_tag="BSU17480" downshifts 1828702 /Source="Nicolas_upshifts" /id="D947" /incds=0 /nref=31 /ntot=125 /MaxReadThrough="3.06401" /MaxDrop="4.27622" /score="-0.54122646" /energy="-8.3" /TU="U1394,U1396" /idTUdmin="U1394" /TUdmin="-440" /isTUend="FALSE" CDS 1828855..1829106 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389631.1" /db_xref="EnsemblGenomes-Gn:BSU17490" /db_xref="EnsemblGenomes-Tr:CAB13633" /db_xref="SubtiList:BG13470" /db_xref="UniProtKB/Swiss-Prot:O31800" /translation="MLGINVEKSNENLIINWQLSKIEIPIKEINDVFLDPNYGGEEKS AVRIGFPYGSTDRVVIKTARNTYILFTTNPALIMSKIVS*" gene 1828855..1829106 /gene="ynzG" /locus_tag="BSU_17490" /old_locus_tag="BSU17490" promotor_-35 1829132..1829139 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1829150..1829169 /Source="Nicolas_upshift_promotors" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1829163..1829292 /Source="Nicolas_S_feature" /locus_tag="new_1881406_1881535" /HighExp="LoTm, Etha, LPhT, B60, M9-stat, T3.0H, T3.30H, Salt, T4.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.968584" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.997, 1, 1" /label="S627" upshifts 1829163 /Source="Nicolas_upshifts" /id="U1397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=3172 /SigmaFactorBS="ttaataaacagtttatgtcccttttaaatTTATCTATtaatg ttctgTGTGGTAAAATTTAGTGAGAtgatttaaggaggaggagcatttatggaagaaa t" /listShort="S627, ynaB, ynaC, ynaD" /GFF_Attribute="listLong" CDS 1829293..1829727 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" /function="17.2: Prophage functions" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; defective phage region" /protein_id="NP_389632.2" /db_xref="EnsemblGenomes-Gn:BSU17500" /db_xref="EnsemblGenomes-Tr:CAB13634" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG12254" /db_xref="UniProtKB/Swiss-Prot:P94480" /translation="MEDATFHFKDPASPQEISDIEQKLGVTFPNDYKEFLLQHNGMEM FDGIEILSLEGIIEYNEVQDFPEGYVLIGYHFDGRYVIDTNKSKNGLGYMLYLDSIDD IEDAINLDSNFEIWFDMLVSLNGTKYWEVNPNLQEYYKLVSE*" gene 1829293..1829727 /gene="ynaB" /locus_tag="BSU_17500" /old_locus_tag="BSU17500" CDS 1829797..1830588 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389633.1" /db_xref="EnsemblGenomes-Gn:BSU17510" /db_xref="EnsemblGenomes-Tr:CAB13635" /db_xref="SubtiList:BG12255" /db_xref="UniProtKB/Swiss-Prot:P94481" /translation="MTIYEQIKDALKNKINELVSPQEVKKTLQEKYGTNPDSIILSDY CYNRYNKGISFNKHLFEYMNRSSYKYLGENSLYTGLIFRKSKGEDKEVIVGEWVNGVK SLREASVTNNQINDQAEIISKEQLVNLYNEYNQILRYEMNVLNCKPTELRHLIGRIGE FICAIQTNGTLARQTNQHGFDVVSDGRRISVKTTAQSSGFISINKNTFYDFDDFFVVQ YVNDDFKVIFFGSKEEVQKISRIYGSQYEVEISLLKKLNKEYQLN*" gene 1829797..1830588 /gene="ynaC" /locus_tag="BSU_17510" /old_locus_tag="BSU17510" promotor_-10 complement(1829905..1829924) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1829913) /Source="Nicolas_upshifts" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1829940..1829942) /Source="Nicolas_upshift_promotors" /id="U1398" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.702297702297702" /psig="0.988011988011988" /xcortree=382 /SigmaFactorBS="gaggtgcttattaaaagaaatccccttattaTACcggttata acaataaTCTGATAAAATAATGCTATCcggattagttccgtatttttcttgaagggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1830584 /Source="Nicolas_upshifts" /id="D948" /incds=0 /nref=10 /ntot=182 /MaxReadThrough="4.47202" /MaxDrop="6.29359" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-836" /isTUend="FALSE" downshifts 1830650 /Source="Nicolas_upshifts" /id="D949" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="3.36892" /MaxDrop="4.40772" /score="3.60743536" /energy="-14.4" /TU="U1397" /idTUdmin="U1397" /TUdmin="-770" /isTUend="FALSE" promotor_-35 1830861..1830869 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1830881..1830899 /Source="Nicolas_upshift_promotors" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1830892 /Source="Nicolas_upshifts" /id="U1399" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.628371628371628" /psig="0.628371628371628" /xcortree=3199 /SigmaFactorBS="gcaatattgttgaataagaatagttttaaAGAGGTTATtgtt gtcttcaTATTGAAATAAAGATTAAGtatattagaggggagttgctttaatgcacata a" /listShort="ynaD" /GFF_Attribute="listLong" CDS 1830923..1831435 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase; putative phage region" /protein_id="NP_389634.1" /db_xref="EnsemblGenomes-Gn:BSU17520" /db_xref="EnsemblGenomes-Tr:CAB13636" /db_xref="GOA:P94482" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12256" /db_xref="UniProtKB/Swiss-Prot:P94482" /translation="MHITTKRLLIREFEFKDWQAVYEYTSDSNVMKYIPEGVFTEEDA KAFVNKNKGDNAEKFPVILRDEDCLIGHIVFYKYFGEHTYEIGWVFNPNYQNKGYASE AAQAILEYGFKEMNLHRIIATCQPENIPSYRVMKKIGMRREGFFKKCIPKGNEWWDEY YYAILEEEWN*" gene 1830923..1831435 /gene="ynaD" /locus_tag="BSU_17520" /old_locus_tag="BSU17520" promotor_-35 1831882..1831888 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1831882 /Source="Nicolas_upshifts" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" promotor_-35 1831884..1831888 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1831902..1831921 /Source="Nicolas_upshift_promotors" /id="U1400" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.665334665334665" /psig="0.994005994005994" /xcortree=3213 /SigmaFactorBS="aaagtgaacctgccacagatgttcattatcttttagggggtt ccaaaaagaccgtattccTATCGATcgctcagagtgaaAATGGTATACTAAAGTTACA a" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI, S631" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1831902..1831921 /Source="Nicolas_upshift_promotors" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1831926..1831994 /Source="Nicolas_S_feature" /locus_tag="new_1884169_1884237" /HighExp="T1.30H, M9-stat, Lbtran, M0t90, T0.30H, T1.0H, T2.30H, Lbstat, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S628" upshifts 1831926 /Source="Nicolas_upshifts" /id="U1401" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=3221 /SigmaFactorBS="aaaaagaccgtattcctaTCGATcgctcagagtgaaAATGGT ATACTAAAGTTACAatcacaggaaggaattacaatttttttagatctacataaaatca t" /listShort="S628, ynaE, S629, ynaF, ynaG, ynzI, S630, ynaI" /GFF_Attribute="listLong" CDS 1831995..1832636 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389635.1" /db_xref="EnsemblGenomes-Gn:BSU17530" /db_xref="EnsemblGenomes-Tr:CAB13637" /db_xref="InterPro:IPR024976" /db_xref="SubtiList:BG12257" /db_xref="UniProtKB/Swiss-Prot:P94483" /translation="MNLIGYIEERFQNLELIPSIYNQWGTGIHFCLGENIYQLKANEE LNLKMFRIVYEQTSIIFNELFEQNDDIFLVTNMYKHKKKEKCIRKLKVYQPFLKCKNH LNQIMVKTYPYPFEINKAEEYEMQQFSLLCKPRDLRVTELLKAASNEDFPQKPKFGGY SIDYPDVFFVNITKDIIFFIYDDRGCEVIAHDFKRIRPLYEKYHDWVEEYKCM*" gene 1831995..1832636 /gene="ynaE" /locus_tag="BSU_17530" /old_locus_tag="BSU17530" S_feature 1832637..1832724 /Source="Nicolas_S_feature" /locus_tag="new_1884880_1884967" /HighExp="M0t90, Lbtran, Lbstat, T1.30H, S2, T1.0H, T0.30H, MG 150, M9-stat, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S629" CDS 1832725..1833078 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389636.1" /db_xref="EnsemblGenomes-Gn:BSU17540" /db_xref="EnsemblGenomes-Tr:CAB13638" /db_xref="SubtiList:BG12258" /db_xref="UniProtKB/Swiss-Prot:P94484" /translation="MVLCDDERSAFLLVLDERLVDFDSQGGNHISVYLVTHFELSDQS YKDVLSFNDDLLGMEHNCSYAMDILSVKEELDFDFPFNMLAIKSYVQELIKMLGIDIT LPEMKERDFDKLSQN*" gene 1832725..1833078 /gene="ynaF" /locus_tag="BSU_17540" /old_locus_tag="BSU17540" CDS 1833122..1833397 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389637.1" /db_xref="EnsemblGenomes-Gn:BSU17550" /db_xref="EnsemblGenomes-Tr:CAB13639" /db_xref="GOA:P94485" /db_xref="SubtiList:BG12259" /db_xref="UniProtKB/Swiss-Prot:P94485" /translation="MNVKKAAAVFSITIPIISAILIINFFTGFMSIPWQGMPVFFPLL LSPIGIILAFVSIKTNKRCAVYGIVLNAIMFPFPFFWFIGGALLFGV*" gene 1833122..1833397 /gene="ynaG" /locus_tag="BSU_17550" /old_locus_tag="BSU17550" downshifts complement(1833498) /Source="Nicolas_upshifts" /id="D950" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="1.74772" /MaxDrop="3.30031" /score="-7.48025946" /energy="-14.4" /TU="NA" /idTUdmin="U1402" /TUdmin=308 /isTUend="FALSE" CDS 1833510..1833674 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="YP_003097730.1" /db_xref="EnsemblGenomes-Gn:BSU17559" /db_xref="EnsemblGenomes-Tr:CAX52623" /db_xref="GOA:C0H415" /db_xref="UniProtKB/Swiss-Prot:C0H415" /translation="MDRKKDEIQRKYREQMREKKEREKEDGSSHTFEIVVVLAIIILM FFFNSVFKAF*" gene 1833510..1833674 /gene="ynzI" /locus_tag="BSU_17559" /old_locus_tag="BSU17559" S_feature 1833675..1833813 /Source="Nicolas_S_feature" /locus_tag="new_1885918_1886056" /HighExp="M0t90, Lbstat, S1, Lbtran, S2, M40t90, T1.30H, Glu, T1.0H, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S630" CDS 1833814..1834284 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; defective phage region" /protein_id="NP_389638.3" /db_xref="EnsemblGenomes-Gn:BSU17560" /db_xref="EnsemblGenomes-Tr:CAB13640" /db_xref="SubtiList:BG12261" /db_xref="UniProtKB/Swiss-Prot:P94487" /translation="MKLYNEFINIAKTFNKELDIIPLLYGSLGLEKVTGLDFSPEDID LLIPLIFLEEKWEKLKKVMELHGYKMVDLHEHEFKKTNTKIGISYIEDLKPFADVDYN NLEIFEDGGAKYHLLTIDDYLKIYKKSLLDGYRRRKKNHKDQSKINILNKLIRN*" gene 1833814..1834284 /gene="ynaI" /locus_tag="BSU_17560" /old_locus_tag="BSU17560" S_feature 1834285..1835108 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1834448..1834466) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834466) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1834482..1834487) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1835109..1836500 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" gene 1835109..1836500 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" CDS 1836531..1838132 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" gene 1836531..1838132 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" S_feature complement(1836647..1836952) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1836947..1836966) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1836952) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" promotor_-35 complement(1836980..1836988) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1838130 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" CDS complement(1838269..1839423) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" gene complement(1838269..1839423) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" downshifts complement(1838272) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" S_feature complement(1839322..1839500) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1839468..1839474 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1839483..1839502) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1839484..1839500 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839494 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1839500) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" promotor_-35 complement(1839517..1839520) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1839527..1839534 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839549..1839568 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1839560..1839664 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1839561 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" CDS 1839665..1841002 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" gene 1839665..1841002 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" S_feature 1841003..1841077 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1841034 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" CDS 1841153..1842652 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" gene 1841153..1842652 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" S_feature 1842653..1842968 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1842926 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" CDS complement(1843135..1843770) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" gene complement(1843135..1843770) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" promotor_-10 complement(1843807..1843826) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843816) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" promotor_-35 complement(1843841..1843848) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1843958..1843965 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843980..1843999 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1843982..1844180 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1843982 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" CDS 1844181..1845596 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" gene 1844181..1845596 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" downshifts 1845586 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" downshifts complement(1845689) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" CDS complement(1845698..1846882) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" gene complement(1845698..1846882) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" S_feature complement(1846883..1846962) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1846955..1846973) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1846966) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" promotor_-35 complement(1846989..1846994) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1847274..1847281 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1847296..1847315 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1847304 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" CDS 1847346..1847807 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" gene 1847346..1847807 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" CDS 1847837..1848271 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" gene 1847837..1848271 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" S_feature complement(1848020..1848325) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1848118 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" S_feature 1848272..1849368 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1848327..1848612) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1848370) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(1848607..1848626) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848612) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" promotor_-35 complement(1848638..1848643) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1848874) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" CDS complement(1848874..1849134) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" gene complement(1848874..1849134) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" promotor_-10 complement(1849155..1849174) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849165) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" promotor_-35 complement(1849187..1849196) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1849369..1849494 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" gene 1849369..1849494 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo S_feature 1849495..1849611 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1849538..1849702 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" gene 1849538..1849702 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" promotor_-35 1849586..1849595 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849609..1849628 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1849613..1849923 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1849613 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" promotor_-35 1849904..1849911 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849925..1849944 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1849925 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" CDS 1849976..1850815 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" gene 1849976..1850815 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" promotor_-10 complement(1849998..1850017) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850019) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1850032..1850035) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1850775 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" downshifts complement(1850921) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" S_feature complement(1850922..1851228) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1850938..1851225) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" gene complement(1850938..1851225) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" downshifts complement(1850965) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" promotor_-35 1851052..1851060 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1851074..1851093 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1851076 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" S_feature 1851087..1851247 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1851219 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" CDS complement(1851268..1851990) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" gene complement(1851268..1851990) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" downshifts complement(1851273) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" misc_feature complement(1852015..1852034) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1852023) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" S_feature complement(1852025..1852149) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1852150..1852506) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" gene complement(1852150..1852506) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" promotor_-10 complement(1852530..1852549) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852547) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" promotor_-35 complement(1852565..1852569) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1852746) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" CDS complement(1852752..1852952) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" gene complement(1852752..1852952) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" downshifts 1852935 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" promotor_-10 complement(1852974..1852993) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852986) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" promotor_-35 complement(1853006..1853015) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1853127..1853315) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" gene complement(1853127..1853315) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" downshifts complement(1853143) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" misc_feature complement(1853284..1853291) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1853297) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-10 complement(1853344..1853363) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853362) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" promotor_-35 complement(1853378..1853385) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1853394..1853531 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" gene 1853394..1853531 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" promotor_-35 1853425..1853430 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1853445..1853463 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1853463..1853565 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1853463 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" CDS 1853566..1853964 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" gene 1853566..1853964 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" S_feature 1853965..1854769 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1854029..1854463) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" gene complement(1854029..1854463) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" downshifts complement(1854045) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1854493..1854512) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854509) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" promotor_-35 complement(1854526..1854533) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1854770..1854958 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" gene 1854770..1854958 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" S_feature 1854959..1855044 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1855003 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" promotor_-35 1855073..1855079 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1855091..1855250 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1855091 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" promotor_-10 1855093..1855104 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1855251..1856813 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" gene 1855251..1856813 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" promotor_-10 complement(1855554..1855573) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855563) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1855588..1855595) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1856843..1857934 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" gene 1856843..1857934 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" CDS 1857924..1859138 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" gene 1857924..1859138 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" promotor_-35 1859216..1859223 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859238..1859257 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859249 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" CDS 1859285..1860091 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" gene 1859285..1860091 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" S_feature complement(1859899..1860997) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1860096..1860713 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" gene 1860096..1860713 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" CDS 1860710..1862350 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" gene 1860710..1862350 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" promotor_-10 complement(1860984..1861003) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860997) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" promotor_-35 complement(1861017..1861025) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1861990..1862756) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1862387..1862752 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" gene 1862387..1862752 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" downshifts 1862729 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" misc_RNA complement(1862749..1863029) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene complement(1862749..1863029) /gene="surA" /locus_tag="BSU_misc_RNA_72" S_feature complement(1862758..1862889) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1862801) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" promotor_-35 1862849..1862858 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1862871..1862880) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1862872..1862891 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1862877 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" S_feature 1862879..1862977 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1862889) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" S_feature complement(1862891..1863021) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1862978..1863736 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" gene 1862978..1863736 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" promotor_-35 1863004 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863006 /Source="Nicolas_upshift_promotors" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863011 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" promotor_-10 complement(1863027..1863046) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863028) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" promotor_-35 complement(1863061..1863068) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1863551..1863762) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1863715 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" S_feature 1863760..1864379 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1863763..1864302) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" gene complement(1863763..1864302) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" promotor_-10 complement(1864303..1864317) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864309) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" promotor_-35 complement(1864331..1864337) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1864357..1864366 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1864379..1864394 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1864381 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" CDS 1864420..1864854 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" gene 1864420..1864854 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" CDS 1864712..1865059 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" gene 1864712..1865059 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" S_feature 1864855..1865187 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1865146..1865155 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865167..1865182 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1865189..1865367 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1865189 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" misc_RNA 1865258..1865337 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 1865258..1865337 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" downshifts 1865324 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" CDS complement(1865396..1866013) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" gene complement(1865396..1866013) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" downshifts complement(1865397) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(1866037..1866056) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866058) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" promotor_-35 complement(1866070..1866077) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1866093..1866100 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1866112 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" promotor_-10 1866114..1866133 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1866163..1866480 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" gene 1866163..1866480 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" promotor_-10 complement(1866180..1866198) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866183) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1866212..1866219) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1866499..1867152 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " gene 1866499..1867152 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" promotor_-35 1867155..1867162 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1867176..1867195 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1867189 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" CDS 1867216..1867449 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" gene 1867216..1867449 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" S_feature 1867450..1867585 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1867553..1867560 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1867574..1867593 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1867587 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" CDS 1867618..1869621 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" gene 1867618..1869621 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" misc_feature complement(1867822..1867841) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1867839) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 1869611 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" S_feature complement(1869623..1870281) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1869721 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" misc_feature 1869722..1869741 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1869774..1870220 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" gene 1869774..1870220 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" misc_feature 1870244..1870263 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1870252 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" promotor_-10 complement(1870263..1870280) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870281) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" promotor_-35 complement(1870299..1870303) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1870306..1870524 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" gene 1870306..1870524 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" downshifts 1870536 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" S_feature 1870581..1870880 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1870598..1870771) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" gene complement(1870598..1870771) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" downshifts complement(1870611) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(1870809..1870828) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870816) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" promotor_-35 complement(1870842..1870849) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1870851..1870859 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1870871..1870890) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1870871..1870889 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1870882..1870990 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1870882 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" upshifts complement(1870883) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" promotor_-35 complement(1870905..1870912) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1870991..1871698 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" gene 1870991..1871698 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" promotor_-35 1871718..1871725 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871737..1871756 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871745 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" CDS 1871787..1872149 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" gene 1871787..1872149 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" promotor_-35 1872167..1872170 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1872185..1872204 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1872196 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" CDS 1872228..1872719 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" gene 1872228..1872719 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" downshifts 1872715 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" CDS complement(1872750..1873178) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" gene complement(1872750..1873178) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" downshifts complement(1872767) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1873196..1873215) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873208) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" S_feature complement(1873210..1873295) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1873229..1873236) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1873266..1873275 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1873285..1873394 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1873285 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" promotor_-10 1873288..1873307 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1873290..1873309) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873295) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" S_feature complement(1873297..1873380) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1873324..1873327) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1873351 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" CDS complement(1873412..1873804) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" gene complement(1873412..1873804) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" downshifts complement(1873425) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" promotor_-35 1873647..1873652 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1873668..1873686 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1873672 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" promotor_-35 1873782..1873786 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873796..1873810 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1873811..1873830) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873813 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(1873826) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" promotor_-35 complement(1873844..1873853) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873885..1874031) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" gene complement(1873885..1874031) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" downshifts complement(1873906) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" CDS complement(1874063..1874209) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" gene complement(1874063..1874209) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" S_feature 1874209..1874342 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1874209 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 1874220..1874222 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1874225..1874236) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874239) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" promotor_-35 complement(1874251..1874257) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1874332..1874339 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1874344..1874436 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1874344 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1874354..1874373 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1874395) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" CDS 1874437..1877166 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" gene 1874437..1877166 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" misc_feature complement(1874457..1874461) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1874461) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 1877167..1877237 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1877238..1877750 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" gene 1877238..1877750 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" downshifts 1877707 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" promotor_-35 1877776..1877782 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1877795 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" promotor_-10 1877797..1877808 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1877831..1877956 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" gene 1877831..1877956 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" downshifts complement(1877849) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" promotor_-35 1877970..1877976 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1877991..1878002 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1877993 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" CDS 1878021..1878167 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" gene 1878021..1878167 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" CDS 1878204..1878455 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" gene 1878204..1878455 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" downshifts 1878433 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" promotor_-35 1878476..1878481 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1878495..1878514 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1878499..1878590 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1878499 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" CDS 1878591..1878956 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" gene 1878591..1878956 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" CDS 1878972..1879271 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" gene 1878972..1879271 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" downshifts 1879247 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" CDS complement(1879302..1879589) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" gene complement(1879302..1879589) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" downshifts complement(1879323) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" downshifts complement(1879389) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(1879619..1879638) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879631) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" promotor_-35 complement(1879654..1879661) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879677..1880258) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" gene complement(1879677..1880258) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" S_feature 1880259..1880389 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1880284..1880303) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1880301) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" promotor_-35 1880374..1880377 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1880391 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" promotor_-10 1880393..1880412 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1880428..1880835 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" gene 1880428..1880835 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" downshifts 1880831 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" promotor_-35 1880897..1880900 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1880915..1880934 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1880919..1881233 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1880919 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" CDS 1881234..1883201 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" gene 1881234..1883201 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" CDS 1883205..1885625 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" gene 1883205..1885625 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" downshifts 1885605 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" S_feature complement(1885633..1885822) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1885672..1885848) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" gene complement(1885672..1885848) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo downshifts complement(1885676) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" CDS complement(1885823..1886233) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" gene complement(1885823..1886233) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo promotor_-10 complement(1886206..1886225) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886209) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1886240..1886247) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1886274..1886293) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886275) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1886308..1886315) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1886322..1886341) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1886333) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" promotor_-35 complement(1886355..1886364) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1886581..1886586 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1886599..1886618 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1886604 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" S_feature 1886617..1886681 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1886682..1888079 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" gene 1886682..1888079 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" downshifts 1888068 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" downshifts 1888113 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" S_feature complement(1888169..1888915) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1888292..1888299 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1888311 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" promotor_-10 1888312..1888331 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1888382..1889881 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" gene 1888382..1889881 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" promotor_-10 complement(1888914..1888933) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888937) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" promotor_-35 complement(1888947..1888956) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1889829 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" CDS 1889949..1890212 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" gene 1889949..1890212 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" downshifts complement(1890471) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" CDS complement(1890471..1891739) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" gene complement(1890471..1891739) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" S_feature complement(1891740..1891869) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1891870..1893411) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" gene complement(1891870..1893411) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" S_feature complement(1893412..1893733) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1893723..1893742) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1893734) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" promotor_-35 complement(1893757..1893760) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1893960..1893967 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1893980..1893999 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1893987 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 1894006..1894452 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" gene 1894006..1894452 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" CDS 1894459..1895352 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" gene 1894459..1895352 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" misc_feature 1894969..1894988 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1894977 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" CDS 1895425..1896021 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" gene 1895425..1896021 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" downshifts 1896011 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" CDS complement(1896070..1897269) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" gene complement(1896070..1897269) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" S_feature complement(1897270..1897341) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1897329..1897340) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1897341) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" promotor_-35 complement(1897355..1897361) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1897439..1898974) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" gene complement(1897439..1898974) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" downshifts complement(1897451) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" CDS complement(1898985..1899767) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" gene complement(1898985..1899767) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" CDS complement(1899788..1900687) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" gene complement(1899788..1900687) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" CDS complement(1900702..1900923) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" gene complement(1900702..1900923) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" CDS complement(1900938..1902272) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" gene complement(1900938..1902272) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" CDS complement(1902282..1903931) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" gene complement(1902282..1903931) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" promotor_no_box 1902331..1902431 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1902391 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1903975..1905117) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" gene complement(1903975..1905117) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" promotor_-10 complement(1905136..1905154) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905153) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" promotor_-35 complement(1905170..1905175) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905208..1905513) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " gene complement(1905208..1905513) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" CDS complement(1905503..1905676) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" gene complement(1905503..1905676) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" CDS complement(1905784..1907316) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" gene complement(1905784..1907316) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" downshifts complement(1905795) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(1907351..1907370) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907351) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" promotor_-35 complement(1907383..1907392) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1907452..1907844) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" gene complement(1907452..1907844) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" downshifts complement(1907483) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(1907872..1907883) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907879) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" promotor_-35 complement(1907897..1907903) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1907955..1911794) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" gene complement(1907955..1911794) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" downshifts complement(1907967) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" CDS complement(1911802..1922613) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" gene complement(1911802..1922613) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" promotor_-35 1914822..1914825 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1914842..1914861 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1914843 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(1922638..1930305) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" gene complement(1922638..1930305) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" CDS complement(1930322..1938004) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" gene complement(1930322..1938004) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" downshifts complement(1933993) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" upshifts complement(1934037) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" promotor_-10 complement(1934039..1934043) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1934061..1934064) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1934340..1934344 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1934357 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 1934360..1934379 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1938029..1945714) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" gene complement(1938029..1945714) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" S_feature complement(1945715..1945823) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1945808..1945827) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1945823) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" promotor_-35 complement(1945841..1945848) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1946097..1947572) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" gene complement(1946097..1947572) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" downshifts complement(1946109) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" CDS complement(1947606..1948583) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" gene complement(1947606..1948583) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" promotor_-10 complement(1948612..1948630) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948624) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" promotor_-35 complement(1948642..1948650) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948717..1950108) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" gene complement(1948717..1950108) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" downshifts complement(1948731) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" downshifts 1948877 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" promotor_-35 1949898..1949904 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1949918..1949936 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1949929..1950262 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1949929 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" S_feature complement(1950109..1950213) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1950173..1950273) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1950213) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" promotor_-35 1950235..1950240 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1950256..1950274 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1950264 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" promotor_-35 1950322..1950329 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1950342..1950361 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1950345 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" CDS 1950394..1950939 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" gene 1950394..1950939 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" downshifts 1950923 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" tRNA complement(1951033..1951105) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(1951033..1951105) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" downshifts complement(1951131) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" CDS complement(1951158..1951703) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" gene complement(1951158..1951703) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" promotor_-10 complement(1951743..1951762) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951757) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" promotor_-35 complement(1951776..1951783) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952019..1952249) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" gene complement(1952019..1952249) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" downshifts complement(1952033) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(1952275..1952294) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952287) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" promotor_-35 complement(1952306..1952312) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1952341..1952360) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1952351) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 1952364..1952371 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1952385..1952404 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1952389 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" CDS 1952434..1954197 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" gene 1952434..1954197 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" downshifts 1954178 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" CDS complement(1954298..1955155) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" gene complement(1954298..1955155) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" promotor_-10 complement(1955201..1955220) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955221) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" promotor_-35 complement(1955234..1955241) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1955283..1956272 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" gene 1955283..1956272 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" S_feature complement(1955339..1956297) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1956329..1957810) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" gene complement(1956329..1957810) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" downshifts complement(1956342) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" CDS complement(1957827..1962389) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" gene complement(1957827..1962389) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" promotor_no_box 1960850..1960950 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1960910 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(1962390..1962461) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1962441..1962460) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1962458..1962465 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1962461) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" promotor_-35 complement(1962475..1962482) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1962477 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" promotor_-10 1962480..1962499 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1962536..1963438 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" gene 1962536..1963438 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" downshifts 1963418 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" CDS complement(1963490..1964605) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" gene complement(1963490..1964605) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" CDS complement(1964602..1965495) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" gene complement(1964602..1965495) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" promotor_-10 complement(1965500..1965519) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1965508 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" upshifts complement(1965518) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1965533..1965539) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1965548..1965566) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965566) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" promotor_-35 complement(1965582..1965587) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965643..1966011) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" gene complement(1965643..1966011) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" promotor_-10 complement(1966046..1966064) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1966069) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" S_feature complement(1966071..1966190) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1966076..1966084) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1966182..1966201) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966190) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" S_feature complement(1966192..1966288) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1966216..1966223) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1966311..1967027) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" gene complement(1966311..1967027) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" downshifts complement(1966333) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" promotor_-10 complement(1967065..1967084) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967074) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" promotor_-35 complement(1967100..1967103) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1967128..1967134 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1967148..1967166 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967153 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" CDS 1967178..1967483 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " gene 1967178..1967483 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" downshifts 1967467 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" CDS 1967554..1968324 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" gene 1967554..1968324 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" promotor_-35 1968306..1968313 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1968325 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" promotor_-10 1968328..1968347 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1968368..1968901 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" gene 1968368..1968901 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" S_feature 1968902..1968987 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1968944 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" CDS complement(1968980..1970224) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" gene complement(1968980..1970224) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" S_feature 1968989..1969728 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1968994) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" S_feature complement(1970225..1970317) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1970318..1971781) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" gene complement(1970318..1971781) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" CDS complement(1971799..1972833) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" gene complement(1971799..1972833) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" S_feature complement(1972845..1972916) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1972888) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" misc_RNA complement(1972917..1973008) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(1972917..1973008) /gene="mswF" /locus_tag="BSU_misc_RNA_31" promotor_-10 complement(1973036..1973055) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1973048) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" promotor_-35 complement(1973070..1973077) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1973090..1973097 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1973111..1973130 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1973115 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" CDS 1973157..1975199 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" gene 1973157..1975199 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" promotor_-35 1975207..1975216 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1975229..1975244 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1975232 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1975266..1975559 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" gene 1975266..1975559 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" downshifts 1975539 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" S_feature complement(1975584..1975931) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1975615) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" CDS complement(1975932..1976336) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" gene complement(1975932..1976336) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" S_feature complement(1976337..1976432) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1976422..1976437) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1976422..1976541) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" gene complement(1976422..1976541) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" upshifts complement(1976432) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" promotor_-35 complement(1976450..1976459) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1976537..1976543 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976557..1976568 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1976568..1976776 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1976568 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" CDS 1976611..1976733 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" gene 1976611..1976733 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" CDS 1976777..1977070 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" gene 1976777..1977070 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" S_feature 1977071..1977164 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1977121 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" CDS complement(1977186..1978871) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" gene complement(1977186..1978871) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" downshifts complement(1977198) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" S_feature complement(1978872..1978959) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1978951..1978969) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978959) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" promotor_-35 complement(1978983..1978990) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1979128..1979137 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1979147 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" promotor_-10 1979150..1979169 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1979196..1980647 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" gene 1979196..1980647 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" downshifts 1980623 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" CDS complement(1980684..1981382) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" gene complement(1980684..1981382) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" downshifts complement(1980699) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" promotor_-10 complement(1981417..1981436) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981436) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" S_feature complement(1981438..1981651) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1981450..1981457) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981652..1982329) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" gene complement(1981652..1982329) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" S_feature complement(1982330..1984819) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1982502..1983539 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" gene 1982502..1983539 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" promotor_-35 1983736..1983742 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1983757..1983768 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1983769 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" CDS 1983796..1984479 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" gene 1983796..1984479 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" CDS complement(1984820..1985125) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " gene complement(1984820..1985125) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" S_feature complement(1985126..1985227) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1985206..1985225) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985227) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" promotor_-35 complement(1985240..1985247) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1985255..1985357) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1985297) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" CDS complement(1985358..1986536) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" gene complement(1985358..1986536) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" promotor_-10 complement(1986562..1986581) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1986581) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" promotor_-35 complement(1986595..1986604) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1986659..1987147) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" gene complement(1986659..1987147) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" downshifts complement(1986684) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" CDS complement(1987172..1987327) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" gene complement(1987172..1987327) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" CDS complement(1987367..1988122) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" gene complement(1987367..1988122) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" promotor_-35 1988375..1988380 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1988396..1988414 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1988411 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" CDS 1988430..1988786 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" gene 1988430..1988786 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" CDS complement(1988745..1988984) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" gene complement(1988745..1988984) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" S_feature 1988787..1989223 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1988985..1989086) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1989087..1989584) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" gene complement(1989087..1989584) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" S_feature complement(1989585..1989684) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1989685..1990596) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" gene complement(1989685..1990596) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" promotor_-10 complement(1990618..1990629) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990620) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" promotor_-35 complement(1990644..1990650) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1990880..1990887 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1990896 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" promotor_-10 1990902..1990921 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1990943..1991425 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" gene 1990943..1991425 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" CDS 1991435..1991689 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" gene 1991435..1991689 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" S_feature 1991690..1991794 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1991795..1992589 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" gene 1991795..1992589 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" S_feature 1992590..1993600 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1992713..1993585) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" gene complement(1992713..1993585) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" CDS 1993686..1994564 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" gene 1993686..1994564 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" S_feature complement(1994677..1994736) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1994712) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" CDS complement(1994737..1995168) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" gene complement(1994737..1995168) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" promotor_-10 complement(1995188..1995207) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995196) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" S_feature complement(1995198..1995431) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1995221..1995227) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1995432..1995450) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1995432..1996064) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" gene complement(1995432..1996064) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" upshifts complement(1995438) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" promotor_-35 complement(1995466..1995471) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1996202..1996209 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1996224..1996243 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1996228 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" CDS 1996290..1997210 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" gene 1996290..1997210 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" promotor_-10 complement(1996721..1996740) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996736) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(1996755..1996762) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1997211..1997868 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1997707..1998069) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" gene complement(1997707..1998069) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" CDS complement(1998130..1998342) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" gene complement(1998130..1998342) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo promotor_-35 1998381..1998388 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1998403..1998422 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1998406 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" CDS 1998446..1998709 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" gene 1998446..1998709 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" downshifts 1998687 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" CDS complement(1999086..2001686) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" gene complement(1999086..2001686) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" S_feature complement(2001687..2001796) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 2001712..2001719 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2001734..2001753 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2001742..2002369 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 2001742 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" promotor_-10 complement(2001786..2001805) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2001796) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" promotor_-35 complement(2001820..2001826) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2001842..2002301) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(2001884) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" downshifts complement(2002346) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" CDS complement(2002356..2002997) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" gene complement(2002356..2002997) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" S_feature complement(2002998..2003115) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(2003092..2003111) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003115) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" promotor_-35 complement(2003125..2003127) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2003625..2003864) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" gene complement(2003625..2003864) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" downshifts complement(2003645) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" misc_feature complement(2003904..2003923) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2003911) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" promotor_-35 2003970..2003977 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2003992..2004011 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2003999 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" CDS 2004035..2004373 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" gene 2004035..2004373 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" S_feature 2004374..2004970 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(2004407..2004763) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" gene complement(2004407..2004763) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" CDS 2004971..2005336 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" gene 2004971..2005336 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" S_feature complement(2005345..2006471) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(2005388) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" CDS 2005558..2006217 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" gene 2005558..2006217 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" downshifts 2006295 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" CDS complement(2006472..2007395) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" gene complement(2006472..2007395) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" promotor_-10 complement(2007251..2007270) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2007254) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" promotor_-35 complement(2007282..2007289) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2007406..2007425) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(2007427) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" promotor_-35 complement(2007440..2007447) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(2007448..2007621) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" gene complement(2007448..2007621) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" CDS 2007766..2007990 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" gene 2007766..2007990 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" CDS complement(2007994..2008449) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" gene complement(2007994..2008449) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" promotor_-35 2008509..2008516 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2008531..2008550 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2008535 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" CDS 2008574..2008834 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" gene 2008574..2008834 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" downshifts 2008781 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" promotor_-35 2009249..2009252 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009266..2009285 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009283 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2009395 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" CDS 2009612..2009752 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" gene 2009612..2009752 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo downshifts 2009749 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" promotor_-35 2009834..2009841 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2009853..2009872 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2009854 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" CDS 2009907..2011022 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" gene 2009907..2011022 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" promotor_-35 2010746..2010754 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2010763 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" promotor_-10 2010766..2010784 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2011019..2011141 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" gene 2011019..2011141 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" downshifts 2011135 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" CDS complement(2011267..2011920) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " gene complement(2011267..2011920) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo downshifts complement(2011541) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" CDS complement(2011957..2012304) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" gene complement(2011957..2012304) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo CDS complement(2012297..2012590) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" gene complement(2012297..2012590) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" upshifts 2012741 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" misc_feature 2012742..2012761 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2012799..2013134 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" gene 2012799..2013134 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" promotor_no_box complement(2013173..2013273) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(2013180) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" CDS complement(2013181..2016786) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" gene complement(2013181..2016786) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" upshifts complement(2013213) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2016787..2016931) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(2016924..2016943) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2016931) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" S_feature complement(2016933..2017018) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(2017019..2017318) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" gene complement(2017019..2017318) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo S_feature complement(2017319..2017456) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(2017434..2017452) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017456) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" promotor_-35 complement(2017466..2017472) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2017489..2017872) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" gene complement(2017489..2017872) /gene="asrE" /locus_tag="BSU_misc_RNA_74" S_feature complement(2017503..2017739) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 2017536..2017538 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2017546) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" promotor_-10 2017554..2017573 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2017559 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" S_feature 2017581..2017734 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 2017640..2017732 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" gene 2017640..2017732 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" downshifts 2017691 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2017741..2017875) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 2017757 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" downshifts complement(2017784) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" upshifts complement(2017875) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" S_feature complement(2017877..2018000) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(2017884..2017885) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2018001..2018843) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" gene complement(2018001..2018843) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" promotor_-35 2018338..2018341 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2018351 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2018357..2018361 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2018869..2018884) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(2018870) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" S_feature complement(2018872..2018954) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(2018896..2018905) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(2018956..2019042) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(2018999) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" CDS complement(2019043..2019501) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" gene complement(2019043..2019501) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" CDS complement(2019511..2021313) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" gene complement(2019511..2021313) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" promotor_-10 complement(2021337..2021356) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(2021353) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" promotor_-35 complement(2021368..2021375) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(2021415..2021972) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /translation="MTNFVHKTVNGLKSLLDEKGAIKLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" gene complement(2021415..2021972) /gene="yobM" /locus_tag="BSU_19010" /old_locus_tag="BSU19010" S_feature complement(2021979..2022374) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 2022037..2022042 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 2022058..2022076 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 2022067 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" S_feature 2022069..2022195 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 2022100..2023536 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" gene 2022100..2023536 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" promotor_-10 complement(2022360..2022379) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2022374) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" promotor_-35 complement(2022393..2022399) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2023537..2023868 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 2023850..2023858 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2023869..2023887 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2023870..2023962 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 2023870 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" CDS 2023963..2026383 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" gene 2023963..2026383 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" S_feature complement(2026305..2026940) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 2026384..2026841 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 2026816..2026823 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026835..2026854 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2026843..2026953 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 2026843 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" misc_RNA 2026853..2026960 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" gene 2026853..2026960 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" downshifts 2026938 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" CDS complement(2026971..2027303) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" gene complement(2026971..2027303) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" downshifts complement(2026985) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" CDS complement(2027368..2028093) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" gene complement(2027368..2028093) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" CDS complement(2028108..2028851) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" gene complement(2028108..2028851) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" promotor_-10 complement(2028879..2028898) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028898) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" promotor_-35 complement(2028912..2028918) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2028929..2029504) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" gene complement(2028929..2029504) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" CDS complement(2029510..2030211) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" gene complement(2029510..2030211) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" promotor_-10 complement(2030241..2030260) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2030241) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" promotor_-10 complement(2030245..2030260) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2030275..2030282) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2030275..2030282) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2030285) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" CDS complement(2030288..2030770) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" gene complement(2030288..2030770) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" misc_feature complement(2030809..2030826) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2030813) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" CDS complement(2030824..2031765) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" gene complement(2030824..2031765) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" downshifts complement(2030857) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(2031795..2031814) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031803) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" promotor_-35 complement(2031828..2031832) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2031836..2031845 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2031858..2031877 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2031866 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" S_feature 2031881..2031945 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 2031917..2031922 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2031938..2031956 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2031947 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" CDS 2031971..2032516 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" gene 2031971..2032516 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" downshifts 2032475 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" CDS complement(2032543..2032866) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" gene complement(2032543..2032866) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" downshifts complement(2032550) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(2032887..2032906) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2032898) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" promotor_-35 complement(2032919..2032926) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2032987..2032993 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2033004 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" promotor_-10 2033008..2033027 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2033060..2033737 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" gene 2033060..2033737 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" downshifts 2033729 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" CDS complement(2033827..2034363) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" gene complement(2033827..2034363) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" downshifts complement(2033850) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2034390..2034409) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034410) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" promotor_-35 complement(2034423..2034430) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2034500..2035282) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" gene complement(2034500..2035282) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" downshifts complement(2034509) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2035304..2035322) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035323) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" promotor_-35 complement(2035336..2035342) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2035379..2035386 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2035401..2035420 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2035405 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" CDS 2035453..2035950 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" gene 2035453..2035950 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" promotor_-35 2035957..2035960 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 2035976..2035995 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 2035978 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" CDS 2036014..2036991 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" gene 2036014..2036991 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" downshifts 2036963 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" promotor_-35 2037088..2037095 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2037110..2037129 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2037117 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" CDS 2037153..2038211 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" gene 2037153..2038211 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" S_feature 2038212..2038281 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 2038265..2038271 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2038283..2038302 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2038283 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" CDS 2038331..2039443 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" gene 2038331..2039443 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" CDS 2039462..2040061 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" gene 2039462..2040061 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" downshifts 2039999 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" downshifts 2040043 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" S_feature complement(2040083..2040581) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(2040119) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" promotor_-35 2040553..2040562 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2040565..2040583) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2040574..2040768 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 2040574 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" promotor_-10 2040575..2040594 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2040581) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" promotor_-35 complement(2040600..2040605) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2040656..2041519) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" gene complement(2040656..2041519) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" downshifts complement(2040669) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" downshifts 2040725 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" downshifts complement(2040757) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" S_feature 2040770..2041537 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 2041515..2041519 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2041528..2041542 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2041539 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2041558..2041577) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041571) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" S_feature complement(2041573..2041766) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(2041589..2041595) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041767..2043542) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" gene complement(2041767..2043542) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" S_feature complement(2043543..2043673) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(2043666..2043868) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" gene complement(2043666..2043868) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" downshifts complement(2043718) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" promotor_-10 complement(2043866..2043885) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(2043884) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" S_feature complement(2043886..2044078) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(2043898..2043905) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(2044107..2044733) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" gene complement(2044107..2044733) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" downshifts complement(2044123) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" promotor_-10 complement(2044767..2044786) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(2044780) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" promotor_-35 complement(2044800..2044807) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(2044883..2045374) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" gene complement(2044883..2045374) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" downshifts complement(2044892) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2045386..2045404) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(2045398) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" promotor_-35 complement(2045418..2045424) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(2045449..2045781) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" gene complement(2045449..2045781) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" S_feature complement(2045782..2046072) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 2045797..2045802 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 2045817..2045835 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 2045819 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" CDS 2045859..2046086 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" gene 2045859..2046086 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" CDS complement(2046073..2046549) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" gene complement(2046073..2046549) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" S_feature 2046087..2046594 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(2046550..2046652) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 2046567..2046572 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2046587..2046605 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2046596 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" CDS 2046616..2046879 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" gene 2046616..2046879 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" promotor_-10 complement(2046632..2046651) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2046652) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2046654..2047179) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(2046665..2046669) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2046884..2047117 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" gene 2046884..2047117 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" downshifts 2047104 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" CDS complement(2047203..2047547) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" gene complement(2047203..2047547) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" downshifts complement(2047224) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" S_feature complement(2047548..2047620) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(2047616..2047635) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047620) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" S_feature complement(2047622..2047725) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(2047649..2047654) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2047712..2047727) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047725) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" promotor_-35 complement(2047740..2047749) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2047868) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" CDS complement(2047904..2048107) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" gene complement(2047904..2048107) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" promotor_-10 complement(2048128..2048147) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048146) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" S_feature complement(2048148..2048214) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(2048163..2048170) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2048180..2048187 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 2048199 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" misc_feature complement(2048201..2048213) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2048201..2048220 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 2048204..2048336 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(2048225) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" CDS 2048337..2049824 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" gene 2048337..2049824 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" promotor_-10 complement(2048780..2048797) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048786) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2048810..2048818) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2049810 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" promotor_-35 2049872..2049877 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049893..2049911 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049898 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" CDS 2049925..2051823 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" gene 2049925..2051823 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" promotor_-10 complement(2050868..2050887) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2050876) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2050901..2050910) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2051813..2052658 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" gene 2051813..2052658 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" S_feature 2052659..2054165 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(2052691..2054028) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" gene complement(2052691..2054028) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" downshifts complement(2052702) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" promotor_-10 complement(2054056..2054075) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054071) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" S_feature complement(2054073..2055231) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(2054090..2054097) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2054149..2054152 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2054167..2054186 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2054167 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" CDS 2054247..2055212 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" gene 2054247..2055212 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" downshifts 2055200 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" CDS complement(2055262..2056515) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" gene complement(2055262..2056515) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" downshifts complement(2055276) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" CDS complement(2056531..2059365) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" gene complement(2056531..2059365) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" promotor_-10 complement(2059460..2059479) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059475) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" S_feature complement(2059477..2059593) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(2059494..2059501) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2059594..2061510) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" gene complement(2059594..2061510) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" CDS complement(2061521..2062435) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" gene complement(2061521..2062435) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" promotor_-10 complement(2062439..2062458) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(2062454) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" promotor_-35 complement(2062475..2062479) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(2062499..2063089) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" gene complement(2062499..2063089) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" CDS complement(2063182..2064426) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" gene complement(2063182..2064426) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" downshifts complement(2063184) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" promotor_-10 complement(2064489..2064507) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064502) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" S_feature complement(2064504..2064724) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(2064520..2064527) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2064710..2064728) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064724) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" promotor_-35 complement(2064740..2064748) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2064808..2066025) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" gene complement(2064808..2066025) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" downshifts complement(2064834) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2066058..2066077) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066066) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" promotor_-35 complement(2066091..2066098) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2066261..2066884) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" gene complement(2066261..2066884) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" S_feature complement(2066885..2067035) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 2066911..2066917 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2066923 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" promotor_-10 2066931..2066942 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2066949..2066957 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2066965..2067065 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2066969..2066987 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2066980 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2067018..2067036) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2067025..2067110 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 2067025 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" upshifts complement(2067035) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" promotor_-35 complement(2067052..2067058) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2067086..2067093 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2067106..2067125 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2067112 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" CDS 2067150..2068508 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" gene 2067150..2068508 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" promotor_-10 complement(2067492..2067503) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067497) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2067517..2067523) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2068524..2069372 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" gene 2068524..2069372 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" promotor_-10 complement(2068788..2068807) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2068795) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2068821..2068829) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2069335 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" downshifts complement(2069367) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" CDS complement(2069398..2070063) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" gene complement(2069398..2070063) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" downshifts complement(2069412) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" CDS complement(2070082..2070432) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" gene complement(2070082..2070432) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" CDS complement(2070429..2070707) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" gene complement(2070429..2070707) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" promotor_-10 complement(2070734..2070753) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070750) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2070768..2070774) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2070783..2071679) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" gene complement(2070783..2071679) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" promotor_-35 2071521..2071530 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2071541 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" promotor_-10 2071544..2071563 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2071559..2071777 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(2071703..2071722) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071723) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" promotor_-35 complement(2071734..2071741) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2071778..2072251 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" gene 2071778..2072251 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" downshifts 2072248 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" CDS complement(2072286..2072522) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" gene complement(2072286..2072522) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" downshifts complement(2072294) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(2072545..2072564) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2072560) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" promotor_-35 complement(2072578..2072587) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2072607..2073941) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" gene complement(2072607..2073941) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" S_feature complement(2073942..2074077) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(2074074..2074093) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074084) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" promotor_-35 complement(2074108..2074115) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2074173..2074180 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2074195..2074214 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2074198 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" S_feature 2074199..2074305 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 2074306..2074695 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" gene 2074306..2074695 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" downshifts 2074705 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" CDS complement(2075102..2075440) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" gene complement(2075102..2075440) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" promotor_-35 2075463..2075470 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075484..2075503 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2075493 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" S_feature 2075497..2075569 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(2075528..2075547) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2075531) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" promotor_-35 complement(2075559..2075565) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2075570..2076178 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" gene 2075570..2076178 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" downshifts 2076168 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" CDS complement(2076221..2076823) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" gene complement(2076221..2076823) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" CDS complement(2076839..2077750) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" gene complement(2076839..2077750) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" promotor_-10 complement(2077779..2077798) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077795) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" promotor_-35 complement(2077814..2077819) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2077871..2077874 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2077889..2077908 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2077891 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" CDS 2077934..2078134 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" gene 2077934..2078134 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" CDS 2078134..2079624 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" gene 2078134..2079624 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" promotor_-10 complement(2078869..2078880) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2078873) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2078894..2078900) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2079612 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" CDS complement(2079659..2081059) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" gene complement(2079659..2081059) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" downshifts complement(2079683) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" promotor_-35 2080830..2080839 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2080851..2080866 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2080865 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2081079..2081098) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2081099) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" promotor_-35 complement(2081112..2081119) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2081158..2081167 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2081173 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" promotor_-10 2081180..2081199 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2081212..2081913 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" gene 2081212..2081913 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" promotor_-35 2081938..2081946 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2081960..2081979 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2081965 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" CDS 2082001..2082252 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" gene 2082001..2082252 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" downshifts 2082273 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" CDS complement(2082323..2083144) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" gene complement(2082323..2083144) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" downshifts complement(2082349) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" S_feature complement(2083145..2083226) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(2083227..2083928) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" gene complement(2083227..2083928) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" S_feature complement(2083929..2084018) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(2084003..2084022) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084018) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" promotor_-35 complement(2084038..2084042) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2084076..2084082 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2084097..2084108 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2084114 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" CDS 2084130..2084255 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" gene 2084130..2084255 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" downshifts 2084253 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" CDS complement(2084295..2084609) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" gene complement(2084295..2084609) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" downshifts complement(2084307) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2084630..2084648) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2084637) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" promotor_-35 complement(2084659..2084667) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2084670..2085281) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" gene complement(2084670..2085281) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" CDS complement(2085359..2085535) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" gene complement(2085359..2085535) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" downshifts complement(2085363) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" upshifts complement(2085374) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" promotor_-10 complement(2085378..2085397) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2085413..2085416) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2085549..2085567) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(2085570) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" S_feature complement(2085572..2085793) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(2085583..2085588) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 2085593..2085598 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2085613..2085631 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2085615 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" CDS 2085654..2085797 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" gene 2085654..2085797 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" CDS complement(2085794..2086474) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" gene complement(2085794..2086474) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" S_feature 2085798..2086809 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(2086501..2086520) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086507) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" promotor_-35 complement(2086534..2086543) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086625..2086849) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" gene complement(2086625..2086849) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" downshifts complement(2086639) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2086890..2086909) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2086902) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" CDS complement(2086936..2087214) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" gene complement(2086936..2087214) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" CDS complement(2087211..2088626) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" gene complement(2087211..2088626) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" promotor_-35 2087882..2087885 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2087901..2087920 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2087906 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2088655..2089482) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " gene complement(2088655..2089482) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" CDS complement(2089460..2090770) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" gene complement(2089460..2090770) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" CDS complement(2090779..2091432) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " gene complement(2090779..2091432) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" CDS complement(2091417..2092106) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" gene complement(2091417..2092106) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" CDS complement(2092113..2093447) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" gene complement(2092113..2093447) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" CDS complement(2093428..2093583) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" gene complement(2093428..2093583) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" promotor_-10 complement(2093466..2093484) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093482) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" promotor_-35 complement(2093500..2093505) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093577..2093810) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" gene complement(2093577..2093810) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" downshifts complement(2093584) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" promotor_-35 2093686..2093690 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093699..2093713 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093714 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2093715..2093734) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093724) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2093749..2093758) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093770..2094549) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" gene complement(2093770..2094549) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" CDS complement(2094578..2095858) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" gene complement(2094578..2095858) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" promotor_-10 complement(2095226..2095244) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095242) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2095258..2095265) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2095826..2095844) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2095836) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" promotor_-35 complement(2095860..2095865) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2095923..2096228) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " gene complement(2095923..2096228) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" downshifts complement(2096056) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" promotor_-10 complement(2096252..2096271) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(2096267) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" promotor_-35 complement(2096285..2096294) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 2096364..2096373 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2096387..2096406 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2096387 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" upshifts complement(2096408) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2096410..2096424) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2096433..2096437) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2096433..2096834 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" gene 2096433..2096834 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" CDS 2096841..2097794 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" gene 2096841..2097794 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" downshifts 2097784 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" CDS complement(2097865..2099013) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" gene complement(2097865..2099013) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" downshifts complement(2097882) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" promotor_-35 2099026..2099030 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2099039..2099058) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2099046..2099065 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099048) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2099056 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2099317..2099325 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099339..2099358 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099342 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" CDS 2099383..2100408 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 2099383..2100408 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 2099786 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" SCAR 2099802..2099803 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 2100400 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" CDS complement(2100452..2100883) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" gene complement(2100452..2100883) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" downshifts complement(2100457) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" CDS complement(2100884..2101417) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" gene complement(2100884..2101417) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" promotor_-35 2101421..2101427 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2101438..2101548 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 2101438 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" promotor_-10 2101440..2101459 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2101445..2101464) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101465) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" promotor_-35 complement(2101480..2101481) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2101549..2101974 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" gene 2101549..2101974 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" downshifts 2101962 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" S_feature 2102007..2103238 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(2102024..2103361) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" gene complement(2102024..2103361) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" CDS complement(2103433..2103627) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" gene complement(2103433..2103627) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" downshifts complement(2103446) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" CDS complement(2103640..2104203) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" gene complement(2103640..2104203) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" CDS complement(2104213..2104980) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" gene complement(2104213..2104980) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" promotor_-10 complement(2105004..2105023) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105021) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" promotor_-35 complement(2105034..2105041) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2105058..2105639) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" gene complement(2105058..2105639) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" S_feature complement(2105640..2105755) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(2105787..2106038) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" gene complement(2105787..2106038) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" downshifts complement(2105800) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2106061..2106080) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2106075) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" CDS complement(2106124..2107392) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" gene complement(2106124..2107392) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" promotor_-10 complement(2107426..2107445) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107445) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" promotor_-35 complement(2107457..2107464) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2107599..2107618 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2107602 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" CDS 2107641..2108636 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" gene 2107641..2108636 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" CDS 2108657..2109298 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" gene 2108657..2109298 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" S_feature 2109299..2110400 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(2109337..2109957) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" gene complement(2109337..2109957) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" downshifts complement(2109363) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" CDS complement(2109958..2110464) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" gene complement(2109958..2110464) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" CDS complement(2110461..2111255) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" gene complement(2110461..2111255) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" CDS complement(2111339..2111872) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" gene complement(2111339..2111872) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" downshifts complement(2111344) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" promotor_-35 2111802..2111807 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2111818..2112764 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 2111820 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" promotor_-10 2111824..2111842 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2111890..2112501) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" gene complement(2111890..2112501) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" promotor_-10 complement(2112533..2112552) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2112552) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" promotor_-35 complement(2112565..2112570) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2112721 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" CDS complement(2112761..2113534) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" gene complement(2112761..2113534) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" downshifts complement(2112796) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" CDS complement(2113576..2114010) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" gene complement(2113576..2114010) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" downshifts complement(2113588) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" promotor_-10 complement(2114039..2114058) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(2114050) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" S_feature complement(2114052..2114116) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(2114072..2114079) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(2114095) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" CDS complement(2114117..2115793) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" gene complement(2114117..2115793) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" S_feature complement(2115794..2115984) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(2115973..2115992) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115984) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" promotor_-35 complement(2116007..2116010) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2116082..2117215) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" gene complement(2116082..2117215) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" downshifts complement(2116098) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" misc_feature complement(2117237..2117256) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2117240) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" CDS complement(2117275..2117892) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" gene complement(2117275..2117892) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" CDS complement(2117908..2118390) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" gene complement(2117908..2118390) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" S_feature complement(2118391..2118538) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2118529..2118547) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2118539) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" promotor_-35 complement(2118558..2118566) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2118592..2118601 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2118614..2118629 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2118616..2118702 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2118616 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" promotor_-35 2118665..2118672 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2118687..2118706 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2118704 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" CDS 2118733..2119638 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" gene 2118733..2119638 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" misc_feature 2119673..2119692 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2119687 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" S_feature 2119688..2119868 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2119869..2121017 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" gene 2119869..2121017 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" S_feature complement(2120038..2121067) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2121013 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2121049..2121068) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121067) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" promotor_-35 complement(2121083..2121091) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2121098..2121244 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" gene 2121098..2121244 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" promotor_-35 2121137..2121144 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2121158..2121177 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2121169..2121259 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2121169 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" CDS 2121260..2121460 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" gene 2121260..2121460 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" downshifts 2121475 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" CDS complement(2121512..2121694) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" gene complement(2121512..2121694) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" S_feature 2121520..2121825 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2121529) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2121755..2121773) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2121787..2121793) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2121791) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" promotor_-35 2121801..2121807 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2121822..2121833 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2121827 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" CDS 2121850..2122119 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" gene 2121850..2122119 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" downshifts 2121974 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" downshifts 2122102 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" CDS complement(2122147..2122329) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" gene complement(2122147..2122329) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" downshifts complement(2122167) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" CDS complement(2122322..2123002) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" gene complement(2122322..2123002) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" S_feature complement(2123003..2123140) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2123019..2123024 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2123037..2123056 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2123042 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" CDS 2123085..2123774 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" gene 2123085..2123774 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" promotor_-10 complement(2123135) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2123138..2123154) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2123141) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" S_feature complement(2123142..2123531) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2123512..2123531) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2123529) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" promotor_-35 complement(2123543..2123551) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2123774..2124172 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" gene 2123774..2124172 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" promotor_-35 2124165..2124171 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2124186..2124197 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2124197 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" CDS 2124214..2124342 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" gene 2124214..2124342 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" S_feature 2124343..2125323 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2124350..2125240) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" gene complement(2124350..2125240) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" downshifts complement(2124387) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" promotor_-10 complement(2125262..2125281) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125269) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" promotor_-35 complement(2125293..2125299) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2125297 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" CDS complement(2125341..2125487) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" gene complement(2125341..2125487) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" downshifts complement(2125357) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" upshifts complement(2125511) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" promotor_-10 complement(2125512..2125523) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2125538..2125544) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125562..2125819) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" gene complement(2125562..2125819) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" promotor_-10 complement(2125839..2125858) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125854) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" promotor_-35 complement(2125870..2125877) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125884..2129465) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" gene complement(2125884..2129465) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" S_feature complement(2129466..2129537) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2129527..2129546) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2129537) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" S_feature complement(2129582..2129779) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2129625) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" CDS complement(2129641..2129730) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" gene complement(2129641..2129730) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" promotor_-10 complement(2129758..2129777) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129779) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" promotor_-35 complement(2129792..2129799) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2129801..2130307) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" gene complement(2129801..2130307) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" CDS complement(2130311..2131408) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" gene complement(2130311..2131408) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" promotor_-10 complement(2131426..2131437) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131429) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" promotor_-35 complement(2131452..2131458) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131482..2132798) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" gene complement(2131482..2132798) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" downshifts complement(2131495) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" CDS complement(2132795..2133379) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" gene complement(2132795..2133379) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" misc_RNA complement(2133468..2133568) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene complement(2133468..2133568) /gene="gswA" /locus_tag="BSU_misc_RNA_34" downshifts complement(2133475) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" S_feature complement(2133569..2133709) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2133710..2135215) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" gene complement(2133710..2135215) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" promotor_no_box complement(2135151..2135251) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2135191) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" downshifts 2135203 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" promotor_-10 complement(2135241..2135260) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2135257) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" promotor_-35 complement(2135274..2135281) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2135327..2136319) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" gene complement(2135327..2136319) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" downshifts complement(2135345) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" CDS complement(2136364..2136954) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" gene complement(2136364..2136954) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" CDS complement(2136956..2137930) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" gene complement(2136956..2137930) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" CDS complement(2137968..2138987) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" gene complement(2137968..2138987) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" promotor_-10 complement(2139035..2139054) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139045) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" promotor_-35 complement(2139066..2139073) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2139108..2139115 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2139129..2139208 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2139129 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" promotor_-10 2139130..2139149 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2139209..2140036 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " gene 2139209..2140036 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" CDS 2140038..2140802 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" gene 2140038..2140802 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" downshifts 2140791 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" downshifts complement(2140833) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" CDS complement(2140843..2142768) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" gene complement(2140843..2142768) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" promotor_-10 complement(2142799..2142818) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142803) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" S_feature complement(2142805..2142869) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2142833..2142837) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2142870..2143061) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" gene complement(2142870..2143061) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" promotor_-10 complement(2143080..2143098) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143089) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" S_feature complement(2143091..2143396) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2143114..2143119) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2143128..2143134 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2143149..2143160 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2143158 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" CDS 2143225..2143377 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" gene 2143225..2143377 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" downshifts 2143387 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" CDS complement(2143430..2144587) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" gene complement(2143430..2144587) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" downshifts complement(2143441) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2144675..2145075) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2144675..2145075) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" downshifts complement(2144685) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" promotor_-10 complement(2145072..2145091) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145090) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" promotor_-35 complement(2145106..2145112) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2145134..2145430) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" gene complement(2145134..2145430) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" promotor_-10 complement(2145455..2145474) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2145465) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" promotor_-35 complement(2145488..2145495) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2145508..2146137) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" gene complement(2145508..2146137) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" downshifts complement(2146103) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" CDS complement(2146139..2146366) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" gene complement(2146139..2146366) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" promotor_-10 complement(2146394..2146413) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2146409) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" S_feature complement(2146411..2146565) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2146427..2146435) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2146450..2146578) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" gene complement(2146450..2146578) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" upshifts complement(2146565) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" S_feature complement(2146567..2146678) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2146568..2146587) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2146603..2146607) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2146679..2147920) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" gene complement(2146679..2147920) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" promotor_-10 complement(2147634..2147652) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2147643) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" promotor_-35 complement(2147667..2147674) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2147936..2150185) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" gene complement(2147936..2150185) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" promotor_-10 complement(2150201..2150220) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2150217) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2150234..2150240) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2150288..2150794) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" gene complement(2150288..2150794) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" downshifts complement(2150311) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" promotor_-10 complement(2150838..2150857) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2150855) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" promotor_-35 complement(2150871..2150878) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2150876..2150885 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150899..2150918 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2150911 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" CDS 2150932..2151351 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" gene 2150932..2151351 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" S_feature 2151352..2151502 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2151372..2151749) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" gene complement(2151372..2151749) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" downshifts complement(2151405) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" S_feature 2151747..2151892 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2151779..2151797) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2151798) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" promotor_-35 complement(2151811..2151820) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2151893..2151912 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2151894 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" CDS 2151937..2152125 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" gene 2151937..2152125 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" downshifts 2152141 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" CDS complement(2152164..2152535) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" gene complement(2152164..2152535) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" downshifts complement(2152197) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2152547..2152566) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152560) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" promotor_-35 complement(2152579..2152584) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152581..2152826) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" gene complement(2152581..2152826) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" promotor_-10 complement(2152852..2152870) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152857) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" promotor_-35 complement(2152882..2152890) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2152976..2152982 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2152997..2153008 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153004 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" CDS 2153025..2153129 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" gene 2153025..2153129 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" downshifts 2153111 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" CDS complement(2153154..2154116) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" gene complement(2153154..2154116) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" promotor_-35 2153284..2153293 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153305..2153320 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153305 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" S_feature 2153309..2153644 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2153615..2153619 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153635..2153654 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2153646..2154156 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2153646 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" S_feature complement(2154117..2154573) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2154157..2154777 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" gene 2154157..2154777 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" promotor_-10 complement(2154562..2154573) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154573) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" promotor_-35 complement(2154588..2154594) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2154799..2157543 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" gene 2154799..2157543 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" downshifts complement(2157213) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" downshifts 2157529 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" CDS complement(2157619..2158113) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" gene complement(2157619..2158113) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" downshifts complement(2157632) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" CDS complement(2158110..2158769) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" gene complement(2158110..2158769) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" CDS complement(2158788..2159486) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" gene complement(2158788..2159486) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" S_feature complement(2159487..2159578) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2159579..2160871) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" gene complement(2159579..2160871) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" S_feature complement(2160872..2160933) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2160933..2160952) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160933) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2160967..2160974) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2161015..2162196) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" gene complement(2161015..2162196) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" downshifts complement(2161019) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" CDS complement(2162219..2162704) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" gene complement(2162219..2162704) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" promotor_-10 complement(2162652..2162671) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162669) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2162684..2162691) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2162713..2162883) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" gene complement(2162713..2162883) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" S_feature complement(2162884..2162955) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2162917..2162923 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2162938..2162957) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2162938..2162949 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2162945..2163019 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2162945 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2162955) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" S_feature complement(2162957..2163025) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2162973..2162979) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2162989 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" CDS complement(2163026..2165821) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" gene complement(2163026..2165821) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" promotor_-35 2163494..2163498 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2163495 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2163500..2163504 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2164151..2164166) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2164165) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2164179..2164188) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2165822..2165946) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2165947..2166330) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" gene complement(2165947..2166330) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" CDS complement(2166332..2167192) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" gene complement(2166332..2167192) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" CDS complement(2167194..2168027) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" gene complement(2167194..2168027) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" S_feature complement(2168028..2168235) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2168230..2168249) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168235) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" promotor_-35 complement(2168266..2168270) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2168273..2169250) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" gene complement(2168273..2169250) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" CDS complement(2169235..2170428) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" gene complement(2169235..2170428) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" CDS complement(2170433..2171566) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" gene complement(2170433..2171566) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" CDS complement(2171563..2172273) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" gene complement(2171563..2172273) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" CDS complement(2172266..2172679) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" gene complement(2172266..2172679) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" CDS complement(2172695..2173498) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" gene complement(2172695..2173498) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" CDS complement(2173510..2173845) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" gene complement(2173510..2173845) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" promotor_-10 complement(2173865..2173884) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2173875) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" promotor_-35 complement(2173898..2173905) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2173914..2173921 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2173930..2173949) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2173935..2173954 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173941 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" upshifts complement(2173949) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" CDS 2173985..2174857 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" gene 2173985..2174857 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" CDS complement(2174899..2175693) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" gene complement(2174899..2175693) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" downshifts complement(2174924) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" S_feature complement(2175694..2175761) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2175762..2176319) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" gene complement(2175762..2176319) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" S_feature complement(2176320..2176399) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2176444) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" CDS complement(2176466..2177233) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" gene complement(2176466..2177233) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" CDS complement(2177268..2177942) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" gene complement(2177268..2177942) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" CDS complement(2177944..2178447) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" gene complement(2177944..2178447) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" downshifts 2178456 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" promotor_-10 complement(2178511..2178530) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2178511) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" promotor_-35 complement(2178545..2178552) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2178590..2179036) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" gene complement(2178590..2179036) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" downshifts 2179039 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" CDS complement(2179091..2179630) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" gene complement(2179091..2179630) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" downshifts complement(2179104) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2179663..2179681) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2179674) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" promotor_-35 complement(2179693..2179701) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2179702..2180973) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" gene complement(2179702..2180973) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" S_feature complement(2180974..2181041) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2181038..2181057) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181041) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" promotor_-35 complement(2181071..2181078) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2181108..2181127) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2181114) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" S_feature complement(2181116..2181260) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2181138..2181145) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2181242..2181260) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2181260) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2181276..2181281) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2181309..2182595) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" gene complement(2181309..2182595) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" downshifts complement(2181332) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" CDS complement(2182606..2183721) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" gene complement(2182606..2183721) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" CDS complement(2183770..2184852) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" gene complement(2183770..2184852) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" CDS complement(2184863..2185666) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" gene complement(2184863..2185666) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" promotor_-10 complement(2185351..2185370) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2185368) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" promotor_-35 complement(2185382..2185389) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2185659..2186861) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" gene complement(2185659..2186861) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" CDS complement(2186842..2187489) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" gene complement(2186842..2187489) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" downshifts complement(2186936) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" misc_feature complement(2187112..2187115) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2187112) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" downshifts complement(2187332) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" CDS complement(2187494..2188243) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /EC_number="4.1.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10627030, 10714985, 12963367, 17114058; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /db_xref="GOA:P03964" /db_xref="InterPro:IPR001468" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013798" /db_xref="PSEUDO:CAB14182.3" /db_xref="SubtiList:BG11038" /db_xref="UniProtKB/Swiss-Prot:P03964" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIA EVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTF VNEHGARAVLIGESLMRQTSQRKAIHALFRE*" gene complement(2187494..2188243) /gene="trpC" /locus_tag="BSU_22660" /old_locus_tag="BSU22660" /pseudo misc_feature complement(2187527..2187529) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2187530) /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2188236..2189252) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" gene complement(2188236..2189252) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" CDS complement(2189224..2190771) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" gene complement(2189224..2190771) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" S_feature complement(2190850..2190981) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2190893) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2190972..2190991) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2190981) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" CDS complement(2190987..2191370) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" gene complement(2190987..2191370) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" promotor_-35 complement(2191006..2191013) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2191367..2192455) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" gene complement(2191367..2192455) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" promotor_-10 complement(2191496..2191511) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2191509) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2191524..2191532) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2192455..2193627) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" gene complement(2192455..2193627) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" promotor_-10 complement(2193662..2193681) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2193679) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2193694..2193701) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2193702..2194472) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" gene complement(2193702..2194472) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" promotor_-10 complement(2194498..2194517) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2194515) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2194529..2194535) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2194547..2194708) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2194590) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" CDS complement(2194709..2195158) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" gene complement(2194709..2195158) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" promotor_-10 complement(2195201..2195220) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2195208) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" promotor_-35 complement(2195233..2195240) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2195274..2196320) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" gene complement(2195274..2196320) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" CDS complement(2196262..2196963) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" gene complement(2196262..2196963) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" CDS complement(2196970..2197725) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" gene complement(2196970..2197725) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" S_feature complement(2197726..2197811) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2197800..2197819) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2197811) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2197830..2197837) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2197889..2198116) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" gene complement(2197889..2198116) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" downshifts complement(2197910) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" CDS complement(2198138..2198710) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" gene complement(2198138..2198710) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" promotor_-10 complement(2198739..2198758) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2198749) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" S_feature complement(2198751..2198834) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2198771..2198777) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2198879) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" CDS complement(2198898..2199176) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" gene complement(2198898..2199176) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" S_feature complement(2199177..2199402) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2199384..2199403) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2199402) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" promotor_-35 complement(2199420..2199425) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2199550..2201028) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" gene complement(2199550..2201028) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" downshifts complement(2199563) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" S_feature complement(2201029..2201190) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2201177..2201195) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2201202) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" CDS complement(2201209..2201943) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" gene complement(2201209..2201943) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" promotor_-35 complement(2201210..2201215) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2201235) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" CDS complement(2201965..2202168) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" gene complement(2201965..2202168) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" promotor_-10 complement(2202204..2202223) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202225) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" promotor_-35 complement(2202237..2202244) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2202290..2202489) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2202333) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2202464..2202483) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2202489) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" promotor_-35 complement(2202497..2202506) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2202506..2203543) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" gene complement(2202506..2203543) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" CDS complement(2203561..2204871) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" gene complement(2203561..2204871) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" S_feature complement(2204872..2204996) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2204982..2205001) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204996) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2205016..2205019) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2205025..2205219) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" gene complement(2205025..2205219) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" CDS complement(2205216..2206109) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" gene complement(2205216..2206109) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" CDS complement(2206106..2206705) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" gene complement(2206106..2206705) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" promotor_-35 2206578..2206584 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2206593..2206776 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2206595 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" promotor_-10 2206598..2206609 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2206716..2206734) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206735) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" promotor_-35 complement(2206750..2206755) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2206783..2206914 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " gene 2206783..2206914 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" downshifts 2206902 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" CDS complement(2206957..2208006) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" gene complement(2206957..2208006) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" downshifts complement(2206977) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" downshifts complement(2207881) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" CDS complement(2208019..2209167) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" gene complement(2208019..2209167) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" misc_feature 2208348..2208351 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2208375 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2208441 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" downshifts 2209145 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" S_feature complement(2209168..2209307) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2209306..2209325) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209307) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" S_feature complement(2209309..2209399) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2209340..2209347) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2209400..2210074) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" gene complement(2209400..2210074) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" S_feature complement(2210075..2210152) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2210153..2210329) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" gene complement(2210153..2210329) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" promotor_-10 complement(2210341..2210359) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210358) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2210374..2210380) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2210374..2211027) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " gene complement(2210374..2211027) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" promotor_-10 complement(2211057..2211076) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211070) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" promotor_-35 complement(2211092..2211096) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2211120..2212472) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" gene complement(2211120..2212472) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" downshifts complement(2211135) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" CDS complement(2212507..2213424) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" gene complement(2212507..2213424) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" downshifts complement(2212895) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" misc_feature complement(2213046..2213053) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2213049) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" promotor_-10 complement(2213462..2213473) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213471) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" promotor_-35 complement(2213487..2213493) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2213563..2214219) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" gene complement(2213563..2214219) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" downshifts complement(2213577) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2214244..2214263) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2214259) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" CDS complement(2214339..2215313) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" gene complement(2214339..2215313) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" downshifts complement(2214347) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" promotor_-35 2215167..2215172 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215188..2215206 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2215198..2215391 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2215198 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" downshifts 2215349 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" CDS complement(2215422..2216705) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" gene complement(2215422..2216705) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" downshifts complement(2215425) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" promotor_-35 2215463..2215469 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2215481..2215485 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2215481 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2216748..2216767) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216769) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" promotor_-35 complement(2216782..2216789) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2216861..2217445) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" gene complement(2216861..2217445) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" downshifts complement(2216863) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" S_feature complement(2217446..2217527) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2217520..2217539) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2217527) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" promotor_-35 complement(2217553..2217560) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2217604..2218383) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" gene complement(2217604..2218383) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" promotor_-10 complement(2218409..2218424) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2218420) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" promotor_-35 complement(2218436..2218445) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2218469..2218912) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" gene complement(2218469..2218912) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" downshifts complement(2218486) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" CDS complement(2218975..2219697) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" gene complement(2218975..2219697) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" downshifts complement(2219256) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" CDS complement(2219648..2220217) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" gene complement(2219648..2220217) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" promotor_-10 complement(2219966..2219984) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219982) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" promotor_-35 complement(2219999..2220005) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2220236..2220982 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2220277..2221767) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" gene complement(2220277..2221767) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" CDS complement(2221760..2222818) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" gene complement(2221760..2222818) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" promotor_-35 2222108..2222117 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2222128..2222918 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2222128 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" promotor_-10 2222130..2222149 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2222859..2222878) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2222882) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" promotor_-35 complement(2222890..2222897) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2222896..2222902 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2222916..2222935 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2222920..2222989 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2222920 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" promotor_-35 2222969..2222976 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2222991..2223083 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2222991..2223010 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222991 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" CDS 2223084..2223332 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" gene 2223084..2223332 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" downshifts 2223316 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" CDS complement(2223372..2223944) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" gene complement(2223372..2223944) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" downshifts complement(2223392) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2223936..2224243) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" gene complement(2223936..2224243) /gene="fswB" /locus_tag="BSU_misc_RNA_78" S_feature complement(2223945..2224049) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2224242..2224261) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224258) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" promotor_-35 complement(2224275..2224281) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2224370..2224377 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2224388 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" promotor_-10 2224392..2224411 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2224441..2226018 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" gene 2224441..2226018 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" downshifts 2226000 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" CDS complement(2226061..2226828) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" gene complement(2226061..2226828) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" downshifts complement(2226076) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" S_feature 2226330..2226942 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2226855..2226874) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226868) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" promotor_-35 complement(2226889..2226892) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2226902 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" CDS complement(2226940..2228046) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" gene complement(2226940..2228046) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" downshifts complement(2226957) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" CDS complement(2227982..2228566) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" gene complement(2227982..2228566) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" promotor_-35 2228360..2228365 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2228376 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2228380..2228384 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2228517..2228522 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2228534 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" promotor_-10 2228538..2228556 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2228574 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2228615..2228634) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2228619..2228726 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2228623) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" promotor_-35 complement(2228647..2228654) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2228682 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" S_feature complement(2228711..2228769) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2228742) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" CDS complement(2228770..2230539) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" gene complement(2228770..2230539) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" downshifts complement(2228826) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" CDS complement(2230536..2231258) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" gene complement(2230536..2231258) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" S_feature complement(2231259..2231338) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2231339..2232514) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " gene complement(2231339..2232514) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" CDS complement(2232534..2234162) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" gene complement(2232534..2234162) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" CDS complement(2234159..2234698) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" gene complement(2234159..2234698) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" S_feature complement(2234699..2234792) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2234793..2235527) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" gene complement(2234793..2235527) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" promotor_-10 complement(2235536..2235555) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235559) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2235570..2235574) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2235619..2236155) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" gene complement(2235619..2236155) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" promotor_-10 complement(2235624..2235643) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235628) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2235658..2235665) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2236160..2236750) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" gene complement(2236160..2236750) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" CDS complement(2236738..2237886) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" gene complement(2236738..2237886) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" promotor_-10 complement(2237908..2237926) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237915) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" promotor_-35 complement(2237941..2237946) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238009..2238548) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" gene complement(2238009..2238548) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" downshifts complement(2238022) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2238557..2238574) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2238572) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2238589..2238594) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238603..2239196) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" gene complement(2238603..2239196) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" CDS complement(2239186..2239941) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" gene complement(2239186..2239941) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" promotor_-35 2239785..2239794 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2239807..2239826 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2239816 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2239987..2240006) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2240002) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" promotor_-35 complement(2240020..2240027) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2240167..2240174 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2240185..2240204 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2240190 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" CDS 2240222..2240746 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" gene 2240222..2240746 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" CDS complement(2240760..2241134) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" gene complement(2240760..2241134) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" downshifts complement(2240776) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2241196..2241215) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241208) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2241227..2241234) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2241247..2241711) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" gene complement(2241247..2241711) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" promotor_-35 2241582..2241586 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2241600..2241604 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2241603 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2241744..2242940) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" gene complement(2241744..2242940) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" CDS complement(2242955..2243602) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" gene complement(2242955..2243602) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" CDS complement(2243613..2244698) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" gene complement(2243613..2244698) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" S_feature complement(2244699..2244827) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2244828..2244972) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" gene complement(2244828..2244972) /gene="fswA" /locus_tag="BSU_misc_RNA_36" promotor_-10 complement(2244989..2245008) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244999) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" promotor_-35 complement(2245023..2245030) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2245092..2245436) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" gene complement(2245092..2245436) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" downshifts complement(2245107) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2245468..2245486) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245481) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" promotor_-35 2245495..2245500 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2245501..2245507) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2245515..2246437 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2245515 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" promotor_-10 2245516..2245534 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2245522..2245537) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245525) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" S_feature complement(2245527..2245593) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2245550..2245559) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2245588..2245596) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245593) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" promotor_-35 complement(2245610..2245618) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2245671..2246225) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" gene complement(2245671..2246225) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" downshifts complement(2245681) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2246251..2246270) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246269) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" S_feature complement(2246271..2246670) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2246282..2246288) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2246492..2246728 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" gene 2246492..2246728 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" CDS complement(2246671..2246877) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" gene complement(2246671..2246877) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" misc_feature complement(2246910..2246929) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2246932) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" CDS complement(2246986..2247240) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" gene complement(2246986..2247240) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo promotor_-35 2247120..2247129 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2247131..2247520) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" gene complement(2247131..2247520) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo S_feature 2247143..2248214 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2247143..2247162 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2247143 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" CDS complement(2247498..2247701) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" gene complement(2247498..2247701) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" CDS 2248110..2248226 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" gene 2248110..2248226 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo downshifts 2248177 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" promotor_-35 2248303..2248312 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248325..2248344 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2248325 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" CDS 2248367..2248579 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" gene 2248367..2248579 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" downshifts 2248573 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" downshifts complement(2248715) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" CDS complement(2248715..2249146) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" gene complement(2248715..2249146) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" S_feature complement(2249147..2249233) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2249216..2249235) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2249233) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" promotor_-35 complement(2249249..2249254) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2249283..2249292 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2249302..2249399 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2249302 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" promotor_-10 2249305..2249320 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2249400..2250272 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" gene 2249400..2250272 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" downshifts 2250179 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" downshifts 2250245 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" CDS complement(2250302..2251621) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" gene complement(2250302..2251621) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" downshifts complement(2250322) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" S_feature complement(2251622..2251686) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2251682..2251701) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2251686) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2251716..2251723) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2251727..2253208) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" gene complement(2251727..2253208) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" misc_feature complement(2252433..2252452) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2252437) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2253159..2253770) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" gene complement(2253159..2253770) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" CDS complement(2253778..2254128) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" gene complement(2253778..2254128) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" CDS complement(2254130..2255146) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" gene complement(2254130..2255146) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" promotor_-35 2254626..2254633 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2254647..2254666 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2254669 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2255159..2255611) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" gene complement(2255159..2255611) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" CDS complement(2255624..2256049) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" gene complement(2255624..2256049) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" CDS complement(2256039..2256659) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" gene complement(2256039..2256659) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" promotor_-10 complement(2256690..2256701) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256700) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" promotor_-35 complement(2256715..2256721) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2256784..2257551) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" gene complement(2256784..2257551) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" downshifts complement(2256814) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" CDS complement(2257563..2258003) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" gene complement(2257563..2258003) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" CDS complement(2258000..2258353) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" gene complement(2258000..2258353) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" promotor_-10 complement(2258378..2258396) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2258389) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" S_feature complement(2258391..2258448) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2258408..2258416) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2258449..2259618) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" gene complement(2258449..2259618) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" promotor_-10 complement(2259647..2259658) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2259662) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" promotor_-35 complement(2259672..2259678) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2259764) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" CDS complement(2259773..2260588) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" gene complement(2259773..2260588) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" CDS complement(2260601..2261785) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" gene complement(2260601..2261785) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" promotor_-10 complement(2261834..2261853) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261852) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" S_feature complement(2261854..2261945) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2261869..2261876) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2261946..2262836) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" gene complement(2261946..2262836) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" CDS complement(2262844..2263071) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" gene complement(2262844..2263071) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" promotor_-10 complement(2262974..2262993) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262985) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2263007..2263014) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2263064) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-10 complement(2263073..2263091) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2263101..2263119) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2263107..2263113) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2263114) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" promotor_-35 complement(2263136..2263141) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2263196) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" CDS complement(2263196..2263645) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" gene complement(2263196..2263645) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" promotor_-10 complement(2263669..2263688) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2263679) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" S_feature complement(2263681..2263757) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2263704..2263708) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2263758..2264402) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" gene complement(2263758..2264402) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" promotor_-10 complement(2264433..2264451) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2264450) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" promotor_-35 complement(2264466..2264471) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2264503..2264718) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" gene complement(2264503..2264718) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" downshifts complement(2264583) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" CDS complement(2264818..2266137) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" gene complement(2264818..2266137) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" downshifts complement(2264825) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" CDS complement(2266155..2267561) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" gene complement(2266155..2267561) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" promotor_-10 complement(2267609..2267628) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267618) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2267620..2267701) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2267643..2267650) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267702..2269129) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" gene complement(2267702..2269129) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" CDS complement(2269174..2270163) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" gene complement(2269174..2270163) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" S_feature complement(2270164..2270243) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2270225..2270244) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270243) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" S_feature complement(2270245..2270565) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2270259..2270266) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2270284..2270291 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2270304..2270323 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2270306 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" CDS 2270345..2270695 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" gene 2270345..2270695 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" S_feature complement(2270567..2270703) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2270610) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" CDS complement(2270704..2271867) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" gene complement(2270704..2271867) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" CDS complement(2271864..2272421) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" gene complement(2271864..2272421) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" promotor_no_box complement(2272351..2272451) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2272391) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" promotor_-35 2272435..2272440 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272456..2272474 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2272458..2272472) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2272462 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" S_feature 2272469..2272643 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2272474..2272477) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2272477) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" CDS 2272496..2272618 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" gene 2272496..2272618 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" promotor_-35 2272619..2272626 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272640..2272659 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2272645 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" CDS 2272681..2273601 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" gene 2272681..2273601 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" downshifts 2273590 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" CDS complement(2273633..2273857) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" gene complement(2273633..2273857) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" downshifts complement(2273690) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2273880..2273899) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273887) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" promotor_-35 complement(2273914..2273921) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2273936..2273943 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2273958..2273977 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2273965 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" CDS 2274019..2274936 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" gene 2274019..2274936 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" downshifts 2274911 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" CDS complement(2274976..2275215) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" gene complement(2274976..2275215) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" downshifts complement(2274987) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" CDS complement(2275228..2275551) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" gene complement(2275228..2275551) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" promotor_-10 complement(2275294..2275313) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275295) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2275327..2275334) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2275548..2276579) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" gene complement(2275548..2276579) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" promotor_-10 complement(2275575..2275594) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275582) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" promotor_-35 complement(2275605..2275612) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2276572..2276916) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" gene complement(2276572..2276916) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" CDS complement(2276926..2277396) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" gene complement(2276926..2277396) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" S_feature complement(2277397..2277473) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2277397 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(2277448..2277467) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2277473) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" S_feature complement(2277475..2277581) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2277482..2277489) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2277582..2277920) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" gene complement(2277582..2277920) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" CDS complement(2277917..2279155) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" gene complement(2277917..2279155) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" misc_feature 2278079..2278080 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2278090 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2278145 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2279180..2279198) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2279189) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" promotor_-35 complement(2279215..2279220) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2279260..2279263 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2279278..2279297 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279287 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" CDS 2279321..2279527 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" gene 2279321..2279527 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" promotor_-35 2280010..2280013 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2280028..2280047 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2280044 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" CDS 2280076..2281308 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" gene 2280076..2281308 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" CDS 2281155..2281517 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" gene 2281155..2281517 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" S_feature complement(2281334..2281513) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2281367) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" CDS complement(2281514..2281900) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" gene complement(2281514..2281900) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" CDS complement(2281904..2282863) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" gene complement(2281904..2282863) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" S_feature complement(2282864..2282934) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2282935..2284281) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" gene complement(2282935..2284281) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" S_feature complement(2284282..2284356) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2284357..2285136) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" gene complement(2284357..2285136) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" CDS complement(2285142..2286101) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" gene complement(2285142..2286101) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" promotor_-10 complement(2286123..2286142) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286142) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" promotor_-35 complement(2286157..2286164) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2286198..2286205 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2286219..2286505 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2286219 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" promotor_-10 2286221..2286240 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2286235..2286480 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" gene 2286235..2286480 /gene="pswI" /locus_tag="BSU_misc_RNA_91" CDS 2286506..2287342 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" gene 2286506..2287342 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" downshifts 2287340 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" CDS complement(2287383..2289026) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" gene complement(2287383..2289026) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" downshifts complement(2287395) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" promotor_-35 2289044..2289050 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2289057 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2289064..2289075 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2289082..2289101) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2289087) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" promotor_-35 2289133..2289140 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289154..2289173 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289156 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" CDS 2289198..2290214 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" gene 2289198..2290214 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" downshifts 2290201 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" promotor_-35 2290263..2290272 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290285..2290300 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2290289 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" CDS 2290324..2291085 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" gene 2290324..2291085 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" downshifts 2290993 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" downshifts 2291081 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" S_feature complement(2291113..2291313) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2291129..2291254) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" gene complement(2291129..2291254) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo downshifts complement(2291156) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" CDS complement(2291247..2291279) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" gene complement(2291247..2291279) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo promotor_-10 complement(2291307..2291326) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291313) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" promotor_-35 complement(2291339..2291346) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2291361..2292284) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" gene complement(2291361..2292284) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" promotor_-10 complement(2292310..2292329) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292323) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" promotor_-35 complement(2292343..2292348) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2292422..2292429 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292443..2292462 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2292445..2292510 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2292445 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" CDS 2292511..2293980 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" gene 2292511..2293980 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" downshifts 2293963 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" downshifts 2294031 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" CDS complement(2294105..2295514) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" gene complement(2294105..2295514) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" downshifts complement(2294122) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" downshifts complement(2294195) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" misc_feature complement(2295578..2295596) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2295580) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" CDS complement(2295624..2296868) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" gene complement(2295624..2296868) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" S_feature complement(2296869..2297143) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2296889..2296896 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296910..2296929 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2296910 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" CDS 2296941..2297228 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" gene 2296941..2297228 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" promotor_-10 complement(2297125..2297144) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2297145) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" promotor_-35 complement(2297160..2297163) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2297259..2298086 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " gene 2297259..2298086 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" downshifts 2297903 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" downshifts 2298079 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" S_feature complement(2298091..2299011) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2298134) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2298204..2298210 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2298224..2298242 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2298233 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" CDS 2298266..2298994 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" gene 2298266..2298994 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" CDS complement(2299035..2300150) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" gene complement(2299035..2300150) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" downshifts complement(2299056) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" CDS complement(2300168..2301691) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " gene complement(2300168..2301691) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" promotor_-10 complement(2301274..2301293) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301296) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" promotor_-35 complement(2301308..2301312) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301684..2302106) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" gene complement(2301684..2302106) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" promotor_-35 2302135..2302142 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302156..2302175 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2302170..2302323 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2302170 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" downshifts 2302280 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" CDS complement(2302308..2302838) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" gene complement(2302308..2302838) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" S_feature 2302325..2302960 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2302855..2302866) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2302862) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" promotor_-35 complement(2302881..2302887) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2302890..2303858) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" gene complement(2302890..2303858) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" downshifts complement(2302906) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" CDS complement(2303929..2304651) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" gene complement(2303929..2304651) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" downshifts complement(2303940) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" CDS complement(2304644..2305303) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" gene complement(2304644..2305303) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" S_feature complement(2305304..2305383) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2305384..2306151) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" gene complement(2305384..2306151) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" promotor_-10 complement(2306201..2306220) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306216) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" promotor_-35 complement(2306235..2306242) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2306419..2306856) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" gene complement(2306419..2306856) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" downshifts complement(2306428) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" promotor_-10 complement(2306880..2306899) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2306901) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" promotor_-35 complement(2306914..2306921) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2306954..2306960 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2306973 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" promotor_-10 2306975..2306993 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2307017..2307910 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" gene 2307017..2307910 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" promotor_-35 2307943..2307950 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2307966..2307985 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2307974 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" CDS 2308011..2309180 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" gene 2308011..2309180 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" downshifts 2309163 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" CDS 2309253..2310089 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" gene 2309253..2310089 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" downshifts 2310087 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" downshifts complement(2310151) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" CDS complement(2310151..2311425) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" gene complement(2310151..2311425) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" CDS complement(2311448..2312431) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" gene complement(2311448..2312431) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" CDS complement(2312445..2313437) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" gene complement(2312445..2313437) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" CDS complement(2313459..2314883) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" gene complement(2313459..2314883) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" CDS complement(2314904..2315995) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" gene complement(2314904..2315995) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" CDS complement(2316014..2317108) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" gene complement(2316014..2317108) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" CDS complement(2317120..2318019) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" gene complement(2317120..2318019) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" misc_feature complement(2318055..2318074) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2318060) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" S_feature complement(2318062..2318143) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2318144..2320222) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" gene complement(2318144..2320222) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" promotor_-10 complement(2320282..2320301) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320299) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" promotor_-35 2320309..2320316 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2320318..2320321) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320330..2320349 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2320337 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" CDS 2320375..2320611 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" gene 2320375..2320611 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" downshifts 2320602 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" CDS complement(2320653..2321558) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" gene complement(2320653..2321558) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" downshifts complement(2320656) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" CDS complement(2321576..2322994) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" gene complement(2321576..2322994) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" misc_feature complement(2321871..2321890) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2321888) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2323009..2324127) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" gene complement(2323009..2324127) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" CDS complement(2324161..2325300) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" gene complement(2324161..2325300) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" CDS complement(2325328..2326191) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" gene complement(2325328..2326191) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" CDS complement(2326216..2327397) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" gene complement(2326216..2327397) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" downshifts complement(2326977) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" misc_feature complement(2327084..2327090) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2327087) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box complement(2327311..2327411) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2327351) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2327444..2327462) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2327462) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" promotor_-35 complement(2327478..2327483) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2327524..2328255) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" gene complement(2327524..2328255) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" downshifts complement(2327531) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2328278..2328297) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2328289) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2328312..2328315) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2328334..2328954) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" gene complement(2328334..2328954) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" CDS complement(2328969..2329262) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" gene complement(2328969..2329262) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" promotor_-10 complement(2329282..2329301) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329288) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" promotor_-35 complement(2329316..2329323) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2329518..2329525 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2329539..2329558 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2329556..2329761 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2329556 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" CDS 2329570..2329722 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" gene 2329570..2329722 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" promotor_-35 2329730..2329737 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2329752..2329771 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2329763 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" CDS 2329795..2330913 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" gene 2329795..2330913 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" downshifts 2330898 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2330940..2331110) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2330983) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2331094..2331109) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331110) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" S_feature complement(2331112..2331240) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2331121..2331130) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2331239..2331258) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331262) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" promotor_-35 complement(2331272..2331280) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2331372) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" CDS complement(2331378..2332181) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" gene complement(2331378..2332181) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" promotor_-10 complement(2332224..2332242) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332230) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" S_feature complement(2332232..2332384) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2332253..2332261) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2332380..2332399) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332392) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" promotor_-35 complement(2332411..2332418) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2332457..2333737) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" gene complement(2332457..2333737) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" downshifts complement(2332472) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2333798..2333809) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333812) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" promotor_-35 complement(2333824..2333830) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2333912..2335642) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" gene complement(2333912..2335642) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" downshifts complement(2333927) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" CDS complement(2335679..2336128) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" gene complement(2335679..2336128) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" S_feature complement(2336129..2336214) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2336226..2337071) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" gene complement(2336226..2337071) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" downshifts complement(2336259) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" CDS complement(2337068..2338969) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" gene complement(2337068..2338969) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" promotor_-35 2338177..2338183 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338198..2338209 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338206 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2338970..2339098) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2339093..2339112) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2339098) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2339127..2339133) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2339144..2340034) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" gene complement(2339144..2340034) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" CDS complement(2340024..2340278) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" gene complement(2340024..2340278) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" CDS complement(2340275..2341621) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" gene complement(2340275..2341621) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" S_feature complement(2341622..2341758) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2341759..2342610) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" gene complement(2341759..2342610) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" CDS complement(2342622..2343017) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" gene complement(2342622..2343017) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" misc_feature complement(2343060..2343079) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2343079) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" S_feature complement(2343081..2343243) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2343281..2343688) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" gene complement(2343281..2343688) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" downshifts complement(2343288) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" CDS complement(2343709..2345061) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" gene complement(2343709..2345061) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" promotor_-10 complement(2344590..2344609) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2344597) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" promotor_-35 complement(2344624..2344630) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2345073..2345552) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " gene complement(2345073..2345552) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" promotor_-10 complement(2345611..2345630) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345622) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" promotor_-35 complement(2345644..2345651) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2345708..2346364) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" gene complement(2345708..2346364) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" downshifts complement(2345715) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" CDS complement(2346365..2347054) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" gene complement(2346365..2347054) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" CDS complement(2347047..2347667) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" gene complement(2347047..2347667) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" promotor_-10 complement(2347373..2347391) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2347391) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" promotor_-35 complement(2347407..2347412) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2347681..2348880) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" gene complement(2347681..2348880) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" CDS complement(2348899..2349300) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" gene complement(2348899..2349300) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" CDS complement(2349307..2349513) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" gene complement(2349307..2349513) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" CDS complement(2349536..2350051) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" gene complement(2349536..2350051) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" CDS complement(2350045..2350968) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" gene complement(2350045..2350968) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" S_feature complement(2350969..2351043) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2351044..2351325) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" gene complement(2351044..2351325) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" promotor_-10 complement(2351345..2351363) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2351368) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" promotor_-35 complement(2351379..2351384) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2351470..2352027) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" gene complement(2351470..2352027) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" downshifts complement(2351482) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" CDS complement(2352052..2353113) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" gene complement(2352052..2353113) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" CDS complement(2353110..2353556) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" gene complement(2353110..2353556) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" promotor_-10 complement(2353605..2353624) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353621) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" promotor_-35 complement(2353637..2353644) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2353643..2354179) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" gene complement(2353643..2354179) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" promotor_-10 complement(2354192..2354203) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2354201) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" promotor_-35 complement(2354217..2354223) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2354249..2354255 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2354268 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" promotor_-10 2354270..2354288 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2354325..2354328 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2354343..2354362 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2354354 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" CDS 2354406..2355362 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" gene 2354406..2355362 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" CDS 2355402..2355797 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" gene 2355402..2355797 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" promotor_no_box 2355680..2355780 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2355740 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2355783 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" CDS complement(2355794..2356669) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" gene complement(2355794..2356669) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" promotor_-10 complement(2356696..2356714) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2356713) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" promotor_-35 complement(2356730..2356735) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2356795..2357223) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" gene complement(2356795..2357223) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" downshifts complement(2356822) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" promotor_-10 complement(2357258..2357277) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357266) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" promotor_-35 complement(2357293..2357297) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2357323..2358159) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" gene complement(2357323..2358159) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" promotor_-10 complement(2358183..2358202) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2358194) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" S_feature complement(2358196..2358740) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2358216..2358223) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2358240..2358245 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2358259..2358278 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2358259 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" S_feature 2358270..2358349 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2358350..2358730 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" gene 2358350..2358730 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" downshifts 2358666 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" downshifts 2358710 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" CDS complement(2358765..2360231) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" gene complement(2358765..2360231) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" downshifts complement(2358785) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" CDS complement(2360224..2361570) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" gene complement(2360224..2361570) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" CDS complement(2361600..2362688) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" gene complement(2361600..2362688) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" misc_RNA complement(2362762..2362961) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" gene complement(2362762..2362961) /gene="swgA" /locus_tag="BSU_misc_RNA_37" downshifts complement(2362812) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" S_feature complement(2362962..2363032) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2362965..2362970 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2362986..2363004 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2362990 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" S_feature 2363000..2363129 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2363018..2363037) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2363032) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" promotor_-35 complement(2363051..2363058) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2363130..2364803 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" gene 2363130..2364803 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" CDS 2364824..2365618 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" gene 2364824..2365618 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" misc_feature 2365154..2365155 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2365160 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" promotor_-35 2365642..2365645 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2365661..2365680 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2365662..2365800 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2365662 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" CDS 2365801..2365974 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" gene 2365801..2365974 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" promotor_-35 2365959..2365963 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2365976..2365995 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2365976 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" CDS 2366008..2366343 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" gene 2366008..2366343 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" downshifts 2366320 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" downshifts 2366410 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" CDS complement(2366436..2367221) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" gene complement(2366436..2367221) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" downshifts complement(2366442) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" misc_feature complement(2367274..2367291) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2367278) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" CDS complement(2367285..2367857) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" gene complement(2367285..2367857) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" CDS complement(2367841..2368602) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" gene complement(2367841..2368602) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" promotor_-10 complement(2368662..2368681) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2368680) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" promotor_-35 complement(2368695..2368702) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2368824..2368830 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2368831 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" promotor_-10 2368844..2368855 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2368874..2369200 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" gene 2368874..2369200 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" S_feature complement(2369017..2369241) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2369060) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" downshifts 2369182 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" CDS complement(2369242..2369421) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" gene complement(2369242..2369421) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" promotor_-10 complement(2369440..2369458) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2369455) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2369473..2369479) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2369492..2369866) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" gene complement(2369492..2369866) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" CDS complement(2369867..2370250) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" gene complement(2369867..2370250) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" CDS complement(2370276..2370623) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" gene complement(2370276..2370623) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" CDS complement(2370607..2371038) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" gene complement(2370607..2371038) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" CDS complement(2371028..2371324) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" gene complement(2371028..2371324) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" CDS complement(2371338..2372309) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" gene complement(2371338..2372309) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" CDS complement(2372362..2373432) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" gene complement(2372362..2373432) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" promotor_-10 complement(2373450..2373469) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2373466) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" promotor_-35 complement(2373483..2373490) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2373615..2373843) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2373656) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" CDS complement(2373844..2374797) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" gene complement(2373844..2374797) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" promotor_-10 complement(2374821..2374840) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374842) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" promotor_-35 complement(2374854..2374860) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2374880..2374886 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2374901..2374919 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2374919 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" CDS 2374940..2376268 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" gene 2374940..2376268 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" S_feature 2376269..2377243 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2376321..2377157) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" gene complement(2376321..2377157) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" S_feature complement(2377158..2377342) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2377244..2377314 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene 2377244..2377314 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" CDS complement(2377381..2377761) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" gene complement(2377381..2377761) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" downshifts complement(2377387) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" promotor_-10 complement(2377790..2377808) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377809) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" promotor_-35 complement(2377823..2377829) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2377848..2377853 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2377869..2377887 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2377878 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" promotor_-35 2377928..2377935 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2377950 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" promotor_-10 2377951..2377970 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2377993..2378238 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" gene 2377993..2378238 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" downshifts 2378135 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" downshifts 2378224 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" S_feature 2378269..2379024 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2378278..2378913) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" gene complement(2378278..2378913) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" downshifts complement(2378303) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" promotor_-10 complement(2378935..2378954) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378952) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" promotor_-35 complement(2378968..2378975) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2378992..2378999 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2379014..2379033 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2379026 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" upshifts complement(2379046) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2379048..2379062) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2379070..2379074) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2379070..2379243 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" gene 2379070..2379243 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" downshifts 2379231 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" CDS complement(2379275..2379589) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" gene complement(2379275..2379589) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" S_feature 2379276..2380343 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2379289) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" CDS complement(2379592..2380653) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" gene complement(2379592..2380653) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" CDS complement(2380715..2381845) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" gene complement(2380715..2381845) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" promotor_-10 complement(2381853..2381871) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2381885) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2381887..2381892) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2381928..2383844) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" gene complement(2381928..2383844) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" downshifts complement(2381955) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" promotor_-35 2382960..2382966 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2382979..2384008 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2382979 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" promotor_-10 2382982..2383000 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2383845..2383911) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2383905..2383924) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383911) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2383939..2383946) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2383961..2384926) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" gene complement(2383961..2384926) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" CDS complement(2384937..2385152) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" gene complement(2384937..2385152) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" S_feature complement(2385153..2385261) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2385262..2386785) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " gene complement(2385262..2386785) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" promotor_-10 complement(2386803..2386822) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386816) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" promotor_-35 complement(2386837..2386844) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2386875..2387048) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" gene complement(2386875..2387048) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" downshifts complement(2386902) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2387064..2387075) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387076) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2387089..2387095) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2387115..2387678) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" gene complement(2387115..2387678) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" S_feature complement(2387679..2387762) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2387763..2387912) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" gene complement(2387763..2387912) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" downshifts complement(2387809) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" promotor_-10 complement(2387949..2387968) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387959) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" promotor_-35 complement(2387984..2387987) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2387996..2389075) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" gene complement(2387996..2389075) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" CDS complement(2389072..2389542) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" gene complement(2389072..2389542) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" promotor_-35 2389487..2389495 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389509..2389517 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2389510..2389683 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2389511 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" promotor_-10 complement(2389578..2389597) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2389590) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" promotor_-35 complement(2389609..2389616) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2389655..2389659 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389675..2389694 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389685 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" CDS 2389722..2390075 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" gene 2389722..2390075 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" CDS 2390072..2390536 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" gene 2390072..2390536 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" downshifts 2390522 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" CDS complement(2390565..2391347) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" gene complement(2390565..2391347) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" downshifts complement(2390576) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" CDS complement(2391358..2392167) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" gene complement(2391358..2392167) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" CDS complement(2392188..2393072) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" gene complement(2392188..2393072) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" CDS complement(2393072..2394001) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" gene complement(2393072..2394001) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" CDS complement(2394070..2394972) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" gene complement(2394070..2394972) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" upshifts complement(2395027) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" promotor_-10 complement(2395035..2395051) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2395062..2395064) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2395126..2397276) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" gene complement(2395126..2397276) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" downshifts complement(2395136) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(2395870..2395888) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2395878) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2395904..2395910) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2396565..2396584) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396582) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2396598..2396607) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2397326..2397345) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397331) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2397361..2397365) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397390..2398682) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" gene complement(2397390..2398682) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" promotor_-10 complement(2398705..2398716) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398716) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" promotor_-35 complement(2398730..2398736) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2398789..2399397) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" gene complement(2398789..2399397) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" downshifts complement(2398804) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2399449..2399468) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399460) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" S_feature complement(2399462..2399530) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2399483..2399490) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2399521..2399539) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399530) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" promotor_-35 complement(2399554..2399560) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2399576..2400058) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" gene complement(2399576..2400058) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" S_feature complement(2400059..2400351) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2400101..2400107 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2400122..2400141 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2400135 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" CDS 2400168..2400935 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" gene 2400168..2400935 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" promotor_-10 complement(2400349..2400367) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2400351) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" S_feature complement(2400353..2401289) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2400381..2400387) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2400936..2401366 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2401323 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" downshifts complement(2401334) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" CDS complement(2401351..2401779) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" gene complement(2401351..2401779) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" promotor_-35 2401775..2401779 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2401789..2401803 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2401798 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" promotor_-10 complement(2401802..2401821) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2401825) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" promotor_-35 complement(2401836..2401843) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2401994..2401999 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2402015..2402033 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2402027 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" CDS 2402056..2402355 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" gene 2402056..2402355 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" promotor_-35 2402368..2402375 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2402390..2402409 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2402401..2402477 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2402401 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" CDS 2402478..2403611 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" gene 2402478..2403611 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" downshifts 2403592 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" CDS complement(2403637..2404026) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" gene complement(2403637..2404026) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" downshifts complement(2403663) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(2404057..2404068) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2404061) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" promotor_-35 complement(2404082..2404088) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2404101..2404108 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2404119..2404138 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2404120 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" CDS 2404159..2404740 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" gene 2404159..2404740 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" downshifts 2404738 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" S_feature 2404783..2405391 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2404783..2405220) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" gene complement(2404783..2405220) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" downshifts complement(2404787) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" S_feature complement(2405221..2405315) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2405311..2405330) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405315) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2405345..2405352) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2405358..2406239) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" gene complement(2405358..2406239) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" promotor_-35 2406235..2406240 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2406256..2406274 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2406272 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" misc_feature complement(2406277..2406296) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2406283) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" S_feature complement(2406285..2406612) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2406301..2406310 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2406317 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" promotor_-10 2406323..2406342 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2406355..2406609 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" gene 2406355..2406609 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" downshifts 2406596 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" CDS complement(2406636..2407529) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" gene complement(2406636..2407529) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" S_feature 2406641..2407442 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2406657) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" CDS complement(2407539..2408855) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" gene complement(2407539..2408855) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" promotor_-10 complement(2408891..2408910) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408902) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" promotor_-35 complement(2408926..2408930) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2408959..2408968 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2408980 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" promotor_-10 2408982..2409001 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2409024..2409767 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" gene 2409024..2409767 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" downshifts 2409749 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" promotor_-35 2409771..2409778 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2409792..2409811 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2409794..2409889 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2409794 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" CDS 2409890..2410834 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" gene 2409890..2410834 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" downshifts 2410805 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" CDS complement(2410857..2411978) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" gene complement(2410857..2411978) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" downshifts complement(2410882) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" CDS complement(2411971..2412621) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" gene complement(2411971..2412621) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" S_feature complement(2412622..2412730) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2412718..2412737) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412730) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2412732..2412845) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2412753..2412757) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2412878..2413240) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" gene complement(2412878..2413240) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" downshifts complement(2412890) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" promotor_-35 2413236..2413240 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2413248..2413262 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2413269 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2413277..2413296) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413279) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2413281..2413402) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2413308..2413315) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2413382 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2413391..2413410) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2413399..2413418 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2413402) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" S_feature complement(2413404..2413543) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2413405..2413509 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2413405 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" promotor_-35 complement(2413424..2413430) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2413473..2413480 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2413494..2413513 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2413511..2415660 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2413511 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" CDS complement(2413569..2414684) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" gene complement(2413569..2414684) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" downshifts complement(2413588) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" S_feature complement(2414685..2414882) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2414883..2416694) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" gene complement(2414883..2416694) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" promotor_-35 2416289..2416295 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2416305 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" promotor_-10 2416307..2416326 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2416334..2416630 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" gene 2416334..2416630 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" CDS complement(2416728..2417222) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" gene complement(2416728..2417222) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" promotor_-10 complement(2417195..2417213) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2417206) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2417223..2417336) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2417225..2417233) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2417231..2417236 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2417252..2417270 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2417267 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2417321..2417339) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2417336) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" S_feature complement(2417338..2417415) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2417355..2417360) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2417381..2417400) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2417415) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2417416..2417419) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2417476..2418288) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" gene complement(2417476..2418288) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" CDS complement(2418314..2418952) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" gene complement(2418314..2418952) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" S_feature complement(2418953..2419084) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2419078..2419097) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2419085..2421124) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" gene complement(2419085..2421124) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" upshifts complement(2419087) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2419112..2419119) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2419131) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" downshifts complement(2419197) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" CDS complement(2421117..2422004) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" gene complement(2421117..2422004) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" misc_RNA complement(2422087..2422261) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" gene complement(2422087..2422261) /gene="tboG" /locus_tag="BSU_misc_RNA_39" downshifts complement(2422121) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" promotor_-35 2422236..2422241 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422257..2422275 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2422265..2422284) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2422267..2423679 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2422267 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" upshifts complement(2422277) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" promotor_-35 complement(2422299..2422306) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2422301..2423068) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" gene complement(2422301..2423068) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" CDS complement(2423105..2423248) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" gene complement(2423105..2423248) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" S_feature complement(2423249..2423395) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2423396..2424301) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" gene complement(2423396..2424301) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" CDS complement(2424282..2424692) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" gene complement(2424282..2424692) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" promotor_-10 complement(2424730..2424749) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2424741) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" S_feature complement(2424743..2424810) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2424764..2424767) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2424811..2425182) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" gene complement(2424811..2425182) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" CDS complement(2425163..2425636) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" gene complement(2425163..2425636) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" CDS complement(2425637..2427772) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" gene complement(2425637..2427772) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" promotor_-35 2427616..2427621 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2427636 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2427637..2427655 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2427851..2428810) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" gene complement(2427851..2428810) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" downshifts complement(2427866) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" CDS complement(2428807..2430003) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" gene complement(2428807..2430003) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" promotor_-10 complement(2428874..2428893) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2428879) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" promotor_-35 complement(2428907..2428914) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2428954..2428972) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2428966) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" promotor_-35 complement(2428987..2428993) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2429181) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" promotor_-10 complement(2429195..2429206) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2429221..2429227) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2430022..2430303) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" gene complement(2430022..2430303) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" CDS complement(2430360..2430779) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" gene complement(2430360..2430779) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" downshifts complement(2430374) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" CDS complement(2430804..2431799) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" gene complement(2430804..2431799) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" CDS complement(2431821..2433134) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" gene complement(2431821..2433134) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" promotor_-10 complement(2433170..2433185) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2433187) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" promotor_-35 complement(2433198..2433207) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2433265..2433711) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" gene complement(2433265..2433711) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" downshifts complement(2433278) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" downshifts complement(2433476) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" CDS complement(2433726..2433899) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" gene complement(2433726..2433899) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" misc_feature 2433835..2433839 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2433840 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2433960..2433979) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433975) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" promotor_-35 complement(2433993..2434000) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2434018..2434023 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2434038 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" promotor_-10 2434039..2434057 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2434072..2434995 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" gene 2434072..2434995 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" CDS complement(2435032..2436387) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" gene complement(2435032..2436387) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" downshifts complement(2435038) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" CDS complement(2436387..2437157) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" gene complement(2436387..2437157) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" CDS complement(2437180..2438115) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" gene complement(2437180..2438115) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" CDS complement(2438140..2439267) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" gene complement(2438140..2439267) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" misc_feature 2439184..2439187 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2439195 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2439268..2439445) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2439307..2439397 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" gene 2439307..2439397 /gene="surC" /locus_tag="BSU_misc_RNA_79" CDS complement(2439467..2441302) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" gene complement(2439467..2441302) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" downshifts complement(2439490) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" CDS complement(2441326..2441889) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" gene complement(2441326..2441889) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" S_feature complement(2441890..2441960) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2441961..2442992) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" gene complement(2441961..2442992) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" promotor_-10 complement(2443033..2443052) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443046) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2443067..2443074) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2443073..2444212) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" gene complement(2443073..2444212) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" promotor_-10 complement(2444085..2444096) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2444089) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" promotor_-35 complement(2444110..2444116) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2444265..2446103) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" gene complement(2444265..2446103) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" downshifts complement(2444287) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" promotor_-10 complement(2446138..2446157) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446155) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" promotor_-35 complement(2446173..2446177) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2446237..2446575) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" gene complement(2446237..2446575) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" downshifts complement(2446243) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" CDS complement(2446592..2447797) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" gene complement(2446592..2447797) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" promotor_-10 complement(2447817..2447835) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447829) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2447851..2447856) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2447860..2448966) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" gene complement(2447860..2448966) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" promotor_-10 complement(2448994..2449005) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449001) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" promotor_-35 complement(2449020..2449026) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2449065..2449068 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2449081 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" promotor_-10 2449084..2449103 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2449095..2449169 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2449170..2449436 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" gene 2449170..2449436 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" downshifts 2449425 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" CDS complement(2449451..2450494) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" gene complement(2449451..2450494) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" downshifts complement(2449496) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" promotor_-10 complement(2450523..2450542) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2450534..2450683) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" gene complement(2450534..2450683) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" upshifts complement(2450535) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" promotor_-35 complement(2450556..2450560) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2450558..2450897) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2450601) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" promotor_-35 2450670..2450676 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2450690..2450709 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2450691 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" CDS 2450724..2450858 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" gene 2450724..2450858 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" downshifts 2450852 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" CDS complement(2450898..2453228) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" gene complement(2450898..2453228) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" promotor_-10 complement(2450915..2450934) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450931) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2450948..2450957) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2453232..2453801) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" gene complement(2453232..2453801) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" promotor_-10 complement(2453828..2453847) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453838) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" promotor_-35 complement(2453862..2453869) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2453868..2454485) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" gene complement(2453868..2454485) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" promotor_-35 2454506..2454511 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2454523 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" promotor_-10 2454527..2454545 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2454546..2454560) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454548) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" S_feature complement(2454550..2455397) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2454569..2454573) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2454569..2455390 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" gene 2454569..2455390 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" promotor_-10 complement(2455385..2455404) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2455391..2455471 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2455398) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" promotor_-35 complement(2455418..2455425) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2455431 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" CDS complement(2455456..2456199) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" gene complement(2455456..2456199) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" downshifts complement(2455486) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" CDS complement(2456196..2456552) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" gene complement(2456196..2456552) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" CDS complement(2456570..2457130) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" gene complement(2456570..2457130) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" CDS complement(2457120..2457689) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" gene complement(2457120..2457689) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" CDS complement(2457701..2457991) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" gene complement(2457701..2457991) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" CDS complement(2457985..2458827) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" gene complement(2457985..2458827) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" downshifts 2458819 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" CDS complement(2458845..2459945) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" gene complement(2458845..2459945) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" CDS complement(2459949..2460467) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" gene complement(2459949..2460467) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" promotor_-10 complement(2460377..2460394) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2460391) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2460410..2460413) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2460468..2461029) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2460501) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" promotor_-35 2460692..2460699 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2460710..2460810 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2460710..2460729 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2460710 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" misc_RNA complement(2460760..2461018) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene complement(2460760..2461018) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" CDS 2460811..2460969 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" gene 2460811..2460969 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" S_feature 2460970..2461216 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2461017..2461036) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461028) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" promotor_-35 complement(2461052..2461056) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2461080..2461227) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2461117) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" downshifts 2461173 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" S_feature 2461218..2462271 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2461222..2461241) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461227) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" promotor_-35 complement(2461254..2461263) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2461275..2462006) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" gene complement(2461275..2462006) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" promotor_-10 complement(2462025..2462044) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462041) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" S_feature complement(2462043..2462151) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2462058..2462064) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2462152..2462170) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462173) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" promotor_-35 complement(2462185..2462190) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462258..2463010) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" gene complement(2462258..2463010) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" downshifts complement(2462261) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" promotor_-35 2462389..2462395 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462409..2462427 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2462416 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2463020..2463039) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2463039) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" promotor_-35 complement(2463053..2463061) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2463105..2463112 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2463127..2463146 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2463131..2463196 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2463131 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" CDS 2463197..2463823 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" gene 2463197..2463823 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" downshifts 2463791 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" CDS complement(2463842..2464735) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" gene complement(2463842..2464735) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" downshifts complement(2463867) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" promotor_-35 2464918..2464924 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2464936..2464955 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2464936 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" CDS 2464987..2465709 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" gene 2464987..2465709 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" CDS complement(2465742..2466152) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" gene complement(2465742..2466152) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" downshifts complement(2465767) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" promotor_-10 complement(2466172..2466190) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466174) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" promotor_-35 complement(2466206..2466211) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2466275..2466283 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2466296 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" promotor_-10 2466297..2466316 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2466348..2466818 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" gene 2466348..2466818 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo downshifts 2466538 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" downshifts 2466670 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" CDS complement(2466726..2468228) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" gene complement(2466726..2468228) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" downshifts complement(2466742) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" promotor_-10 complement(2468335..2468353) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468353) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" S_feature complement(2468355..2468656) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2468370..2468375) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468677..2469096) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" gene complement(2468677..2469096) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" downshifts complement(2468701) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" CDS complement(2469108..>2469236) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2469108..>2469236) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2469232,2469239) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2469233..2469238 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2469234..2469620 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2469234..2469620 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2469587..2469605) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2469602..2470018 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" gene 2469602..2470018 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo misc_feature 2469607..2469621 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2469615) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts 2469626 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" downshifts 2470002 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" CDS 2470018..2470134 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" gene 2470018..2470134 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" S_feature 2470047..2471381 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2470165) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" CDS complement(2470243..2470407) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" gene complement(2470243..2470407) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" promotor_-10 complement(2470337..2470356) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2470363) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" promotor_-35 complement(2470371..2470378) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2470541) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" CDS complement(2470952..2471368) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" gene complement(2470952..2471368) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" CDS complement(2471414..2472712) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" gene complement(2471414..2472712) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" CDS complement(2472699..2473394) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" gene complement(2472699..2473394) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" misc_feature complement(2473460..2473477) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2473469) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" promotor_-35 2473555..2473561 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2473568..2473586 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2473583 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2473662..2474879 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" gene 2473662..2474879 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" promotor_-35 2474121..2474128 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2474143..2474162 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2474159 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2474798..2475046 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" gene 2474798..2475046 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" S_feature complement(2474975..2476022) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2475391..2475948 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" gene 2475391..2475948 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" S_feature 2475949..2476071 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2476024..2476438) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2476067) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" CDS complement(2476439..2476963) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" gene complement(2476439..2476963) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" promotor_-35 2476811..2476818 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2476829..2476848 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2476843 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2476964..2477051) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2477046..2477065) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477051) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2477053..2477206) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2477080..2477087) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2477207..2477683) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" gene complement(2477207..2477683) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" promotor_-10 complement(2477719..2477738) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477733) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" S_feature complement(2477735..2478265) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2477752..2477759) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2478266..2479051) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" gene complement(2478266..2479051) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" CDS complement(2479112..2479339) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" gene complement(2479112..2479339) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" downshifts complement(2479136) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" CDS complement(2479373..2480506) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" gene complement(2479373..2480506) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" misc_feature complement(2480208..2480223) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2480219) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2480507..2480840) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2480841..2481398) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" gene complement(2480841..2481398) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" S_feature complement(2481399..2481583) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2481584..2482066) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" gene complement(2481584..2482066) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" S_feature complement(2482067..2482175) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2482213..2482404) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" gene complement(2482213..2482404) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" downshifts complement(2482220) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" S_feature complement(2482405..2482494) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2482495..2482812) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" gene complement(2482495..2482812) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo promotor_-10 complement(2482601..2482620) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482617) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2482633..2482639) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2482854..2483069) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" gene complement(2482854..2483069) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo promotor_-10 complement(2482882..2482901) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482896) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" promotor_-35 complement(2482916..2482923) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2483070..2483196) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2483197..2483757) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" gene complement(2483197..2483757) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" CDS complement(2483774..2483950) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" gene complement(2483774..2483950) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" promotor_-10 complement(2483784..2483803) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483795) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" S_feature complement(2483797..2483982) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2483816..2483825) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2483983..2484129) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" gene complement(2483983..2484129) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" CDS complement(2484299..2485120) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" gene complement(2484299..2485120) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" promotor_-35 2485128..2485135 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2485130..2485149) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2485147) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2485149..2487153) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2485151..2485170 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2485159 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" CDS 2485237..2486439 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" gene 2485237..2486439 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" CDS 2486608..2487066 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" gene 2486608..2487066 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" downshifts complement(2487198) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" CDS complement(2487223..2488527) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" gene complement(2487223..2488527) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" S_feature complement(2488528..2488607) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2488593..2488612) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488607) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" promotor_-35 complement(2488627..2488634) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488790..2488933) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" gene complement(2488790..2488933) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" CDS complement(2488951..2489916) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" gene complement(2488951..2489916) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" promotor_-35 2489954..2489957 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489972..2489991 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2489999 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" CDS 2490042..2490908 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" gene 2490042..2490908 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" S_feature 2490909..2491009 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2490967 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" CDS complement(2491031..2492068) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" gene complement(2491031..2492068) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" downshifts complement(2491043) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" S_feature complement(2492069..2492155) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2492156..2493091) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" gene complement(2492156..2493091) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" promotor_-10 complement(2493126..2493145) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493133) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" S_feature complement(2493135..2493218) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2493160..2493167) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2493199..2493218) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2493218) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" promotor_-35 complement(2493232..2493239) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2493353) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" CDS complement(2493378..2493767) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" gene complement(2493378..2493767) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" promotor_-35 2494015..2494022 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494038..2494057 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494047 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" CDS 2494101..2494991 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" gene 2494101..2494991 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" promotor_-35 2494679..2494684 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2494700..2494718 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2494707 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2495149..2495466) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" gene complement(2495149..2495466) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" CDS complement(2495424..2496746) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" gene complement(2495424..2496746) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" CDS complement(2496911..2497243) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" gene complement(2496911..2497243) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" CDS complement(2497240..2498004) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" gene complement(2497240..2498004) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" CDS complement(2498017..2498490) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" gene complement(2498017..2498490) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" CDS complement(2498824..2499099) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" gene complement(2498824..2499099) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" misc_feature complement(2499111..2499130) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2499117) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2499185..2499370) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2499371..2500603) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" gene complement(2499371..2500603) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" CDS complement(2500653..2500811) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" gene complement(2500653..2500811) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo CDS complement(2500808..2501011) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" gene complement(2500808..2501011) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo promotor_-10 complement(2500972..2500990) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500989) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" CDS complement(2500996..2501145) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" gene complement(2500996..2501145) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo promotor_-35 complement(2501005..2501010) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2501229) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" CDS complement(2501244..2501807) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" gene complement(2501244..2501807) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" downshifts 2501725 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" promotor_-10 complement(2501837..2501856) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501845) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" promotor_-35 complement(2501871..2501878) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2502036..2502407) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" gene complement(2502036..2502407) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" S_feature complement(2502408..2502637) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2502619..2502638) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2502635) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" promotor_-35 complement(2502652..2502659) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2503203) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" CDS complement(2503217..2503720) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" gene complement(2503217..2503720) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" S_feature complement(2503721..2503945) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2503946..2504800) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" gene complement(2503946..2504800) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" S_feature complement(2504801..2504903) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2504884..2504903) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2504901) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" promotor_-35 complement(2504918..2504921) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2505072..2505079 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2505093..2505112 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2505108 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" S_feature 2505113..2505178 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2505179..2506222 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" gene 2505179..2506222 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" downshifts 2506220 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" promotor_-35 2506507..2506514 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2506521 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" promotor_-10 2506528..2506547 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2506572..2507369 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" gene 2506572..2507369 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" promotor_-35 2507675..2507679 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2507693..2507712 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2507703 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" promotor_-10 complement(2507727..2507741) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507741) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2507750..2507754) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2507750..2508457 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" gene 2507750..2508457 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" downshifts 2508457 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" S_feature 2508502..2508675 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2508657..2508658 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508674..2508693 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2508677..2509005 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2508677 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" CDS 2508781..2508942 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" gene 2508781..2508942 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo promotor_-35 2508971..2508980 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2508993..2509012 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2509007..2509158 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2509007 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" CDS 2509033..2509110 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" gene 2509033..2509110 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" downshifts 2509115 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" S_feature 2509160..2509357 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2509349..2509620) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2509391) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" CDS complement(2509397..2509558) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" gene complement(2509397..2509558) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" CDS complement(2509621..2510376) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" gene complement(2509621..2510376) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" promotor_-10 complement(2510407..2510426) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510423) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" promotor_-35 complement(2510442..2510447) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2510508..2511038) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" gene complement(2510508..2511038) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" promotor_-10 complement(2511084..2511103) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511107) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2511117..2511124) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2511173..2512153 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" gene 2511173..2512153 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" CDS complement(2512427..2513743) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" gene complement(2512427..2513743) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" S_feature complement(2513744..2513857) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2513858..2514727) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" gene complement(2513858..2514727) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" promotor_-10 complement(2514750..2514769) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514767) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" promotor_-35 complement(2514784..2514789) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2514834..2514835) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514842) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" promotor_-35 complement(2514872..2514873) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2514872..2515975 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" gene 2514872..2515975 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" misc_feature 2515865..2515884 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2515871 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(2516222) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" CDS complement(2516248..2517081) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" gene complement(2516248..2517081) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" misc_feature complement(2517111..2517130) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2517120) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" promotor_-35 2517286..2517290 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2517301..2517523 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2517301 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" promotor_-10 2517305..2517324 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2517524..2517787 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" gene 2517524..2517787 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" downshifts 2517775 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" CDS 2517924..2518739 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" gene 2517924..2518739 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" S_feature complement(2519074..2519146) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2519117) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" CDS complement(2519147..2519503) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" gene complement(2519147..2519503) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" CDS complement(2519556..2519915) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" gene complement(2519556..2519915) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" misc_feature complement(2520008..2520027) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2520018) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" CDS complement(2520187..2520288) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" gene complement(2520187..2520288) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" S_feature complement(2520328..2520430) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2520370) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" CDS complement(2520431..2520817) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" gene complement(2520431..2520817) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" misc_feature complement(2520859..2520875) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2520875) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" promotor_-35 2521008..2521014 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2521029..2521040 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2521029 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" CDS 2521066..2521311 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" gene 2521066..2521311 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" CDS 2521329..2521697 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" gene 2521329..2521697 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" CDS 2521716..2522852 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" gene 2521716..2522852 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" CDS 2522871..2523068 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" gene 2522871..2523068 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" CDS 2523084..2523383 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" gene 2523084..2523383 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" downshifts 2523374 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" CDS complement(2523646..2524068) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" gene complement(2523646..2524068) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" promotor_-35 2524066..2524069 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2524085..2524104 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2524100..2524250 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2524100 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" promotor_-10 complement(2524103..2524122) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2524110) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" promotor_-35 complement(2524136..2524143) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2524219..2524238) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2524227) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" CDS 2524251..2524445 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" gene 2524251..2524445 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" promotor_-35 complement(2524253..2524260) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2524463..2524470 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2524486..2524505 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2524490 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" S_feature 2524491..2524575 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2524576..2525625 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" gene 2524576..2525625 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" promotor_-35 2525693..2525700 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2525715..2525734 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2525728 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" CDS 2525756..2526265 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" gene 2525756..2526265 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" downshifts 2526234 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" S_feature 2526279..2527384 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2526307..2528340) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" gene complement(2526307..2528340) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" downshifts complement(2526332) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" CDS complement(2528249..2528416) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" gene complement(2528249..2528416) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" S_feature complement(2528341..2528496) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2528497..2529324) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " gene complement(2528497..2529324) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" CDS complement(2529345..2530154) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" gene complement(2529345..2530154) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" CDS complement(2530171..2530659) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" gene complement(2530171..2530659) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" CDS complement(2530659..2531099) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" gene complement(2530659..2531099) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" downshifts 2531096 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" misc_feature complement(2531136..2531154) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2531140) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" CDS complement(2531289..2534096) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" gene complement(2531289..2534096) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" misc_feature complement(2534312..2534331) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2534318) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" CDS 2534643..2534783 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" gene 2534643..2534783 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" misc_feature 2534764..2534783 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2534774 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" CDS 2534822..2536210 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" gene 2534822..2536210 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" downshifts 2536199 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" S_feature complement(2536232..2536305) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2536274) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" CDS complement(2536306..2536938) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" gene complement(2536306..2536938) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" downshifts complement(2536362) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" promotor_-10 complement(2536992..2537011) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537003) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" promotor_-35 2537017..2537023 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2537026..2537033) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2537037..2537056 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2537042 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" CDS 2537091..2537918 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " gene 2537091..2537918 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" downshifts 2537914 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" promotor_-35 2538031..2538040 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538053..2538068 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2538058 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" CDS 2538114..2538614 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" gene 2538114..2538614 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" CDS 2538614..2539471 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" gene 2538614..2539471 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" promotor_-10 complement(2539489..2539500) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2539508) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2539515..2539521) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2539582..2541486 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" gene 2539582..2541486 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" promotor_-35 2541567..2541573 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2541589..2541607 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2541595 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" CDS 2541620..2541910 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" gene 2541620..2541910 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" S_feature 2541911..2542026 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2542008..2542015 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2542028..2542153 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2542028 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" promotor_-10 2542029..2542047 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2542047..2542147 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" gene 2542047..2542147 /gene="surF" /locus_tag="BSU_misc_RNA_82" downshifts 2542110 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" CDS complement(2542154..2545318) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" gene complement(2542154..2545318) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" downshifts complement(2542170) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" promotor_-35 2543304..2543313 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2543327..2543346 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2543348 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2545334..2545918) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" gene complement(2545334..2545918) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" CDS complement(2546141..2546683) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" gene complement(2546141..2546683) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" S_feature complement(2546684..2546769) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2546767..2546782) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546769) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" promotor_-35 complement(2546795..2546804) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2546838..2547054) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2546872..2547030) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" gene complement(2546872..2547030) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" downshifts complement(2546881) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" promotor_-10 complement(2547052..2547071) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547054) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" S_feature complement(2547056..2547186) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2547085..2547094) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2547187..2547336) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" gene complement(2547187..2547336) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" downshifts 2547330 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" S_feature complement(2547337..2547427) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2547429..2547648) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2547472) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" downshifts 2547594 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" promotor_-10 complement(2547627..2547646) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547648) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" S_feature complement(2547650..2547725) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2547661..2547668) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2547726..2548526) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" gene complement(2547726..2548526) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" S_feature complement(2548595..2548748) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2548638) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2548739..2548758) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2548748) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" promotor_-35 complement(2548773..2548779) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2548789..2549157) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" gene complement(2548789..2549157) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" S_feature complement(2549158..2549254) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2549240..2549259) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2549244..2549247 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2549260) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" promotor_-10 2549263..2549282 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2549265 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" S_feature 2549266..2549472 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2549275..2549279) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2549473..2552415 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" gene 2549473..2552415 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" CDS 2552434..2552916 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" gene 2552434..2552916 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" downshifts 2552896 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" CDS complement(2552952..2553182) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" gene complement(2552952..2553182) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" downshifts complement(2552972) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" S_feature complement(2553183..2553264) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2553265..2554404) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" gene complement(2553265..2554404) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" CDS complement(2554406..2555329) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" gene complement(2554406..2555329) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" downshifts complement(2555322) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" S_feature complement(2555330..2555393) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2555394..2556089) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" gene complement(2555394..2556089) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" promotor_-10 complement(2555829..2555848) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555847) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2555861..2555870) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2556110..2556751) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" gene complement(2556110..2556751) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" promotor_-10 complement(2556318..2556337) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556337) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-35 complement(2556354..2556357) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2556803..2556812 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2556809..2556828) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556815) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" promotor_-10 2556825..2556844 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2556834..2556898 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2556834 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" promotor_-35 complement(2556844..2556847) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2556879..2556886 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2556900 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" promotor_-10 2556902..2556919 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2556944..2557147 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" gene 2556944..2557147 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" downshifts 2557154 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" CDS complement(2557184..2557885) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" gene complement(2557184..2557885) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" downshifts complement(2557196) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" CDS complement(2557950..2559704) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" gene complement(2557950..2559704) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" misc_feature complement(2557978..2557997) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2557988) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-10 complement(2559019..2559034) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559022) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 complement(2559047..2559056) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2559250..2559268) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559264) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" promotor_-35 2559283..2559290 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2559283..2559288) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559305..2559324 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559310 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2559758..2560231) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" gene complement(2559758..2560231) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" downshifts complement(2559765) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" S_feature complement(2560232..2560364) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2560346..2560365) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2560364) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" S_feature complement(2560366..2560474) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2560379..2560386) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2560467..2560486) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2560474) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" CDS complement(2560482..2561117) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" gene complement(2560482..2561117) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" promotor_-35 complement(2560502..2560506) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2560612..2560617 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560633..2560651 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560640 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2561124..2562392) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" gene complement(2561124..2562392) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" CDS complement(2562411..2563340) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" gene complement(2562411..2563340) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" CDS complement(2563346..2563999) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " gene complement(2563346..2563999) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" S_feature complement(2564000..2564104) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2564086..2564105) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564104) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2564121..2564125) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2564151..2565233) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" gene complement(2564151..2565233) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" downshifts complement(2564185) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" promotor_-10 complement(2565249..2565268) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565269) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" promotor_-35 complement(2565283..2565286) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2565359) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" CDS complement(2565364..2565645) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" gene complement(2565364..2565645) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" downshifts complement(2565424) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" CDS complement(2565663..2566079) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" gene complement(2565663..2566079) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" promotor_-10 complement(2565911..2565929) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565930) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2565945..2565950) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2566087..2566353) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" gene complement(2566087..2566353) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" promotor_-35 2566241..2566249 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566264..2566283 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2566272..2567461 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2566272 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" S_feature complement(2566354..2566414) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2566408..2566427) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566414) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" CDS complement(2566438..2569074) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" gene complement(2566438..2569074) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" promotor_-35 complement(2566441..2566448) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2568840..2568858) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568856) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2568872..2568879) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2569075..2569153) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2569154..2569361) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2569154..2569361) /gene="tboA" /locus_tag="BSU_misc_RNA_40" promotor_-10 complement(2569369..2569388) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569384) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" promotor_-35 complement(2569403..2569410) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2569405..2570466) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" gene complement(2569405..2570466) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" promotor_-35 2570375..2570380 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2570386..2570621 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2570387 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" promotor_-10 2570396..2570414 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2570483..2570494) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2570484) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" promotor_-35 complement(2570508..2570514) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2570622..2571350 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" gene 2570622..2571350 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" downshifts complement(2571078) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" CDS 2571372..2572193 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" gene 2571372..2572193 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" CDS 2572254..2572904 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" gene 2572254..2572904 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" CDS 2572921..2573577 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" gene 2572921..2573577 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" downshifts 2573576 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" CDS complement(2573612..2573743) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " gene complement(2573612..2573743) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" downshifts complement(2573630) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" CDS complement(2573765..2573956) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" gene complement(2573765..2573956) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" CDS complement(2573968..2574492) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" gene complement(2573968..2574492) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" upshifts complement(2574079) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-10 complement(2574083..2574094) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2574109..2574115) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2574463..2574474) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2574469) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" promotor_-35 complement(2574489..2574495) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2574550..2576946) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" gene complement(2574550..2576946) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" downshifts complement(2574576) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" promotor_-35 2574796..2574802 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2574810 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" promotor_-10 2574817..2574828 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2574830..2575179 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2574931) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" CDS complement(2576971..2577591) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" gene complement(2576971..2577591) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" CDS complement(2577677..2578792) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" gene complement(2577677..2578792) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" downshifts complement(2577678) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" CDS complement(2578823..2579962) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" gene complement(2578823..2579962) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" promotor_-10 complement(2579529..2579548) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579541) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2579562..2579569) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2579981..2580397) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" gene complement(2579981..2580397) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" S_feature complement(2580398..2580495) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2580480..2580499) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2580495) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" promotor_-35 complement(2580515..2580518) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2580543..2580550 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2580564..2580583 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2580572 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" CDS 2580600..2581865 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" gene 2580600..2581865 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" downshifts 2581864 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" CDS complement(2581907..2582671) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" gene complement(2581907..2582671) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" downshifts complement(2581925) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" misc_RNA complement(2582755..2582955) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" gene complement(2582755..2582955) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" downshifts complement(2582773) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" upshifts 2582942 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2582943..2582952 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2582953..2582972) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2582964) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2582985..2582992) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2583007..2584785) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" gene complement(2583007..2584785) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" CDS complement(2584799..2586073) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" gene complement(2584799..2586073) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" misc_RNA complement(2586163..2586395) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" gene complement(2586163..2586395) /gene="tboH" /locus_tag="BSU_misc_RNA_42" downshifts complement(2586193) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" promotor_-35 2586405..2586408 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2586419..2586438) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2586423..2586442 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2586425..2586709 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2586425 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" upshifts complement(2586438) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" promotor_-35 complement(2586453..2586460) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2586455..2586625) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" gene complement(2586455..2586625) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" promotor_-10 complement(2586656..2586667) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2586673) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" promotor_-35 complement(2586682..2586688) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2586685..2586692 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2586706..2586724 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2586711 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" CDS 2586758..2588314 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" gene 2586758..2588314 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" downshifts 2588293 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" CDS complement(2588341..2588739) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" gene complement(2588341..2588739) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" downshifts complement(2588349) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" CDS complement(2588793..2590997) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" gene complement(2588793..2590997) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" promotor_-10 complement(2591026..2591045) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591033) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" S_feature complement(2591035..2591125) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2591060..2591067) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2591089 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" CDS complement(2591165..2591677) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" gene complement(2591165..2591677) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" downshifts complement(2591170) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" CDS complement(2591683..2594043) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" gene complement(2591683..2594043) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" promotor_-10 complement(2592147..2592166) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2592155) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2592180..2592189) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2594057..2594076) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594068) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" promotor_-35 complement(2594091..2594097) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2594110..2594433) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" gene complement(2594110..2594433) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" promotor_-10 complement(2594454..2594472) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2594465) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" promotor_-35 complement(2594487..2594493) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2594509..2595006) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" gene complement(2594509..2595006) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" S_feature complement(2595007..2595082) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2595076..2595095) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2595082) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" promotor_-35 complement(2595109..2595116) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2595164..2597377) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" gene complement(2595164..2597377) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" downshifts complement(2595169) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" promotor_-35 2596936..2596941 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2596955..2596974 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2596963 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2597416..2597712) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" gene complement(2597416..2597712) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" downshifts 2597623 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" S_feature complement(2597713..2597791) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2597753..2597758 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2597775..2597793 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2597777..2597796) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2597777 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" upshifts complement(2597791) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" S_feature complement(2597793..2598711) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2597811..2597814) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2597828..2599384 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" gene 2597828..2599384 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" promotor_-10 complement(2598697..2598715) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2598711) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" promotor_-35 complement(2598727..2598735) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2599385..2600149 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2599388..2600044) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" gene complement(2599388..2600044) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" promotor_-10 complement(2600063..2600074) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600075) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" promotor_-35 complement(2600088..2600094) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2600127..2600132 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2600148..2600166 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2600151 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" CDS 2600179..2600631 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" gene 2600179..2600631 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" downshifts 2600615 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" downshifts complement(2600670) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" CDS complement(2600688..2600954) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" gene complement(2600688..2600954) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" CDS complement(2600991..2602136) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" gene complement(2600991..2602136) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" upshifts complement(2601043) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" misc_feature complement(2601046) /Source="Nicolas_upshift_promotors" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2601087) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" promotor_-10 complement(2601089..2601108) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2601123..2601128) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2602163..2603191) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" gene complement(2602163..2603191) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" CDS complement(2603221..2603421) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" gene complement(2603221..2603421) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" CDS complement(2603414..2604418) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" gene complement(2603414..2604418) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" CDS complement(2604429..2605034) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" gene complement(2604429..2605034) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" promotor_-10 complement(2605053..2605072) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605069) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" S_feature complement(2605071..2605172) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2605083..2605089) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2605173..2605685) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" gene complement(2605173..2605685) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" promotor_-10 complement(2605714..2605725) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2605729) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" CDS complement(2605733..2607040) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" gene complement(2605733..2607040) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" promotor_-35 complement(2605740..2605746) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2606994) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" promotor_-10 complement(2607064..2607082) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2607079) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" promotor_-35 complement(2607097..2607103) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2607111..2608136) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" gene complement(2607111..2608136) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" promotor_-10 complement(2608173..2608192) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2608193) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" promotor_-35 complement(2608207..2608214) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2608262..2608269 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2608283..2608302 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2608291 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-35 2608323..2608328 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2608337 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" promotor_-10 2608344..2608362 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2608374..2609021 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" gene 2608374..2609021 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" S_feature complement(2608696..2609029) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2609000 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" S_feature complement(2609031..2609228) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2609067..2609189) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" gene complement(2609067..2609189) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" downshifts complement(2609074) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" upshifts complement(2609237) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" promotor_-10 complement(2609238..2609255) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2609262..2609269) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2609274..2609564 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" gene 2609274..2609564 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" misc_feature 2609285..2609304 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2609285..2609432 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2609285 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" CDS 2609571..2609711 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" gene 2609571..2609711 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" downshifts 2609700 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2609760..2609766 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2609774..2609874 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2609781..2609799 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609782 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" upshifts 2609834 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" CDS 2609875..2611329 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" gene 2609875..2611329 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" downshifts 2611330 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" CDS complement(2611370..2612092) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" gene complement(2611370..2612092) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" S_feature 2611375..2611796 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2611386) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" promotor_-10 complement(2612115..2612134) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612132) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" promotor_-35 complement(2612148..2612155) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612195..2612791) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" gene complement(2612195..2612791) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" downshifts complement(2612210) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" promotor_-10 complement(2612834..2612845) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612836) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" S_feature complement(2612838..2612902) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2612860..2612866) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612939..2614102) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" gene complement(2612939..2614102) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" downshifts complement(2612947) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" S_feature complement(2614103..2614178) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2614154..2614172) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614178) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2614188..2614193) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2614219..2615325) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" gene complement(2614219..2615325) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" promotor_-10 complement(2614901..2614919) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614926) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2614935..2614940) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2615237 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2615238..2615241 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2615312..2616181) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" gene complement(2615312..2616181) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" downshifts 2615406 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" CDS complement(2616135..2617730) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" gene complement(2616135..2617730) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" promotor_-10 complement(2617758..2617777) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2617758..2617765 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2617779 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" promotor_-10 2617781..2617800 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617782) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" promotor_-35 complement(2617792..2617799) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2617833..2619020 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" gene 2617833..2619020 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" promotor_-10 complement(2617834..2617853) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617852) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2617868..2617877) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2618735..2618740 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2618749 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" promotor_-10 2618751..2618770 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2618980..2619522 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" gene 2618980..2619522 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" downshifts 2619505 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" CDS complement(2619547..2620404) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" gene complement(2619547..2620404) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" S_feature 2619550..2620259 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2619567) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" CDS complement(2620421..2620864) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" gene complement(2620421..2620864) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" CDS complement(2620925..2622211) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" gene complement(2620925..2622211) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" CDS complement(2622245..2622823) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" gene complement(2622245..2622823) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" S_feature complement(2622824..2622889) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2622874..2622893) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622889) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" S_feature complement(2622891..2623108) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2622901..2623023 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" gene 2622901..2623023 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" promotor_-35 complement(2622907..2622914) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2623144..2623428) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" gene complement(2623144..2623428) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" downshifts complement(2623153) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" CDS complement(2623441..2623779) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" gene complement(2623441..2623779) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" CDS complement(2623782..2624090) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" gene complement(2623782..2624090) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" misc_RNA complement(2624104..2624179) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" gene complement(2624104..2624179) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" promotor_-10 complement(2624191..2624210) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624211) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" promotor_-35 complement(2624224..2624231) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624237..2625103) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" gene complement(2624237..2625103) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" CDS complement(2625096..2625890) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" gene complement(2625096..2625890) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" downshifts 2625893 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" promotor_no_box 2625899..2625999 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2625914..2625932) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2625925) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" promotor_-35 complement(2625948..2625953) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2625959 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2626002 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" downshifts complement(2626037) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" CDS complement(2626040..2626846) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" gene complement(2626040..2626846) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" CDS complement(2626848..2627528) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" gene complement(2626848..2627528) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" CDS complement(2627581..2628099) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" gene complement(2627581..2628099) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" CDS complement(2628096..2628968) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" gene complement(2628096..2628968) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" CDS complement(2628999..2630012) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" gene complement(2628999..2630012) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" upshifts complement(2630053) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" misc_feature complement(2630065..2630083) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2630104..2630799) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" gene complement(2630104..2630799) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" CDS complement(2630836..2631405) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" gene complement(2630836..2631405) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" promotor_-10 complement(2631257..2631272) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631266) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2631285..2631294) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2631444..2631463) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631460) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" promotor_-35 complement(2631477..2631483) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2631556) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" CDS complement(2631558..2632556) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" gene complement(2631558..2632556) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" promotor_-10 complement(2632603..2632622) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632611) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2632634..2632641) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2632679) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" CDS complement(2632690..2633436) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" gene complement(2632690..2633436) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" promotor_-10 complement(2633464..2633483) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633471) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" promotor_-35 complement(2633498..2633505) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2633576..2634868) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" gene complement(2633576..2634868) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" downshifts complement(2633581) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" S_feature complement(2634869..2634927) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2634928..2637570) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" gene complement(2634928..2637570) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" S_feature complement(2637571..2637629) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2637630..2637852) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2637630..2637852) /gene="tboV" /locus_tag="BSU_misc_RNA_44" downshifts complement(2637673) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" promotor_-10 complement(2637881..2637900) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2637893) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" S_feature complement(2637895..2638003) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2637915..2637920) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2637957..2637966 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2637979..2637998 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2637980 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" promotor_-10 complement(2637996..2638010) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638003) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" promotor_-35 complement(2638018..2638022) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2638018..2638209 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" gene 2638018..2638209 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" CDS complement(2638228..2639253) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" gene complement(2638228..2639253) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" downshifts complement(2638258) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" CDS complement(2639286..2641013) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" gene complement(2639286..2641013) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" promotor_-35 2640615..2640618 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640634..2640653 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640640 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 2641009..2641013 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2641022..2641036 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2641036 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2641051..2641069) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2641067) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" promotor_-35 complement(2641085..2641090) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2641144..2642436) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" gene complement(2641144..2642436) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" downshifts complement(2641161) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" CDS complement(2642466..2643440) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" gene complement(2642466..2643440) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" CDS complement(2643437..2644225) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" gene complement(2643437..2644225) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" CDS complement(2644215..2645159) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" gene complement(2644215..2645159) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" CDS complement(2645192..2646022) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" gene complement(2645192..2646022) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" CDS complement(2646030..2647397) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" gene complement(2646030..2647397) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" misc_feature complement(2647461..2647480) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2647467) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2647469..2647558) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2647518..2647537 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2647526 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2647555..2647574) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647558) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" S_feature complement(2647560..2647976) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2647585..2647593) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2647627..2648124 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" gene 2647627..2648124 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" promotor_-10 complement(2647960..2647978) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647976) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" S_feature complement(2647978..2648108) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2647994..2648000) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2648088..2648099) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2648108) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" promotor_-35 complement(2648114..2648120) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2648146..2648733) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" gene complement(2648146..2648733) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" downshifts complement(2648174) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" CDS complement(2648730..2651054) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" gene complement(2648730..2651054) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" S_feature complement(2651055..2651166) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2651151..2651170) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2651166) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" promotor_-35 complement(2651184..2651191) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2651235..2652893) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" gene complement(2651235..2652893) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" downshifts complement(2651254) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2652937..2652955) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2652948) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" promotor_-35 complement(2652971..2652976) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2653045..2654307) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" gene complement(2653045..2654307) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" downshifts complement(2653055) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2654308..2654397) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2654385..2654404) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654397) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" S_feature complement(2654399..2654530) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2654416..2654423) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2654575) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" CDS complement(2654579..2655853) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" gene complement(2654579..2655853) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" S_feature complement(2655854..2656043) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2656030..2656049) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656043) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" promotor_-35 complement(2656064..2656068) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2656081..2657085) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" gene complement(2656081..2657085) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" promotor_-10 complement(2657110..2657129) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2657128) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2657141..2657148) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2657204..2657803) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" gene complement(2657204..2657803) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" downshifts complement(2657225) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" CDS complement(2657816..2659234) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" gene complement(2657816..2659234) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" promotor_-35 2659123..2659127 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2659142..2659146 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2659142 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2659284..2660381) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" gene complement(2659284..2660381) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" CDS complement(2660402..2661958) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" gene complement(2660402..2661958) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" promotor_-35 2660798..2660801 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2660814..2663255 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2660814 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" promotor_-10 2660816..2660835 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2661945..2662973) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" gene complement(2661945..2662973) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" CDS complement(2662997..2663515) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" gene complement(2662997..2663515) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" promotor_-35 2663236..2663239 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2663255..2663259 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2663257 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2663512..2665236) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" gene complement(2663512..2665236) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" S_feature complement(2665237..2665357) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2665358..2665604) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2665358..2665604) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" downshifts complement(2665401) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" S_feature complement(2665605..2665731) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2665713..2665732) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2665731) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" S_feature complement(2665733..2665863) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2665747..2665754) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2665858..2665877) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2665867) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" promotor_-35 complement(2665891..2665894) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2665989..2665998 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666012..2666031 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2666014 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" CDS 2666052..2666387 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" gene 2666052..2666387 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" downshifts 2666381 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" promotor_-35 2666468..2666475 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2666489..2666508 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2666491..2666555 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2666491 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" CDS 2666556..2667011 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" gene 2666556..2667011 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" promotor_-35 2667119..2667125 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2667139..2667157 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2667146 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" CDS 2667195..2668016 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" gene 2667195..2668016 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" downshifts 2668009 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" downshifts 2668073 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" tRNA complement(2668080..2668153) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2668080..2668153) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" downshifts complement(2668114) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" promotor_-10 complement(2668190..2668209) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668193) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" promotor_-35 complement(2668223..2668230) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2668284..2668793) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" gene complement(2668284..2668793) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" downshifts complement(2668301) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" CDS complement(2668809..2669405) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" gene complement(2668809..2669405) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" CDS complement(2669418..2670155) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" gene complement(2669418..2670155) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" promotor_-10 complement(2670237..2670256) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2670253) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" CDS complement(2670266..2671366) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" gene complement(2670266..2671366) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" promotor_-35 complement(2670271..2670276) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2670283) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" promotor_-10 complement(2671389..2671407) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2671405) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" promotor_-35 complement(2671422..2671427) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2671481..2672299) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" gene complement(2671481..2672299) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" downshifts complement(2671493) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" CDS complement(2672307..2672747) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" gene complement(2672307..2672747) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" promotor_-10 complement(2672790..2672809) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672799) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" S_feature complement(2672801..2672943) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2672825..2672829) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2672988) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" CDS complement(2672991..2673215) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" gene complement(2672991..2673215) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" upshifts 2673264 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2673266..2673284 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2673273..2673292) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673293) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" promotor_-35 complement(2673306..2673315) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2673331..2673774) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" gene complement(2673331..2673774) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" CDS complement(2673835..2674596) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" gene complement(2673835..2674596) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" downshifts complement(2673843) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" CDS complement(2674599..2676359) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" gene complement(2674599..2676359) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" CDS complement(2676393..2677001) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" gene complement(2676393..2677001) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" promotor_-35 2676771..2676778 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2676791..2676810 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2676793 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2677002..2677097) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2677087..2677106) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2677097) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" S_feature complement(2677099..2677720) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2677121..2677128) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2677236..2677240 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2677250..2677350 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2677257..2677276 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2677266 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" CDS 2677294..2677740 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" gene 2677294..2677740 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" upshifts 2677310 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" downshifts 2677728 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" downshifts complement(2677766) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" CDS complement(2677784..2679010) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" CDS complement(2677784..2678275) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" gene complement(2677784..2679010) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" gene complement(2677784..2678275) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" downshifts complement(2679124) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" misc_RNA complement(2679136..2679315) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" gene complement(2679136..2679315) /gene="kswC" /locus_tag="BSU_misc_RNA_46" downshifts complement(2679168) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2679340..2679359) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2679347) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" promotor_-35 complement(2679372..2679379) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2679380..2681152) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" gene complement(2679380..2681152) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" promotor_-10 complement(2681179..2681198) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2681193) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" promotor_-35 complement(2681212..2681219) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2681282) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" CDS complement(2681288..2681602) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" gene complement(2681288..2681602) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" promotor_-10 complement(2681628..2681647) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2681642) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" S_feature complement(2681644..2681853) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2681663..2681665) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2681747..2681857) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" gene complement(2681747..2681857) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo promotor_-10 complement(2681843..2681861) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2681853) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" promotor_-35 complement(2681876..2681882) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2681925..2683412) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" gene complement(2681925..2683412) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" S_feature complement(2683413..2683525) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2683506..2683525) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2683525) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" promotor_-35 complement(2683540..2683547) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2683629..2684606) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" gene complement(2683629..2684606) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" downshifts complement(2683637) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" CDS complement(2684642..2685415) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" gene complement(2684642..2685415) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" CDS complement(2685430..2686206) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" gene complement(2685430..2686206) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" downshifts 2685495 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" CDS complement(2686221..2686805) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" gene complement(2686221..2686805) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" promotor_-10 complement(2686847..2686866) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686847) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" promotor_-35 complement(2686879..2686886) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686910..2688592) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" gene complement(2686910..2688592) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" misc_feature complement(2688621..2688640) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2688629) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" downshifts complement(2688717) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" CDS complement(2688781..2689185) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" gene complement(2688781..2689185) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" downshifts complement(2688783) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" CDS complement(2689200..2691557) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" gene complement(2689200..2691557) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" CDS complement(2691578..2693290) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" gene complement(2691578..2693290) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" S_feature complement(2693291..2693363) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2693364..2693897) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" gene complement(2693364..2693897) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" CDS complement(2693904..2694161) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" gene complement(2693904..2694161) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" promotor_-10 complement(2694188..2694207) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694204) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" promotor_-35 complement(2694219..2694226) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2694244..2694263 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2694251 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" CDS 2694295..2695236 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" gene 2694295..2695236 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" promotor_-10 complement(2694968..2694987) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694983) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2695001..2695008) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2695219 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" downshifts complement(2695251) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" CDS complement(2695272..2697686) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" gene complement(2695272..2697686) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" downshifts complement(2695295) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" CDS complement(2697702..2698736) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" gene complement(2697702..2698736) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" S_feature complement(2698737..2699057) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2698818..2699024 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" gene 2698818..2699024 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" S_feature 2699047..2699311 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2699047 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" promotor_-10 complement(2699052..2699071) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2699054..2699068 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2699057) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" promotor_-35 complement(2699086..2699089) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2699091..2699837) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" gene complement(2699091..2699837) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" promotor_-10 complement(2699864..2699883) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2699870..2699876 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2699877) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" promotor_-10 2699890..2699901 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2699897..2699903) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2699904 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" CDS 2699956..2700171 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" gene 2699956..2700171 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" S_feature complement(2700153..2701565) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2700182..2700189 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2700205..2700224 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700213 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" CDS 2700240..2701346 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" gene 2700240..2701346 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" promotor_-35 2701382..2701385 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701401..2701420 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2701405 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" CDS 2701449..2702861 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" gene 2701449..2702861 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" promotor_-10 complement(2701551..2701570) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2701565) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" promotor_-35 complement(2701583..2701592) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2702858..2704192 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" gene 2702858..2704192 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" downshifts 2704190 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" downshifts complement(2704229) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" CDS complement(2704231..2704473) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" gene complement(2704231..2704473) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" S_feature complement(2704474..2704645) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2704533..2704703) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" gene complement(2704533..2704703) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" CDS complement(2704646..2706442) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" gene complement(2704646..2706442) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" promotor_-10 complement(2704748..2704766) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704766) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2704778..2704786) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2706439 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" promotor_-10 complement(2706467..2706486) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2706477) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" promotor_-35 complement(2706501..2706507) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2706537..2706593) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2706561) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" CDS complement(2706594..2708096) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" gene complement(2706594..2708096) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" downshifts complement(2707967) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" promotor_no_box complement(2708071..2708171) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2708111) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" CDS complement(2708115..2708960) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" gene complement(2708115..2708960) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" CDS complement(2708961..2709902) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" gene complement(2708961..2709902) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" CDS complement(2709938..2711239) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" gene complement(2709938..2711239) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" CDS complement(2711270..2712454) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" gene complement(2711270..2712454) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" CDS complement(2712451..2713269) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" gene complement(2712451..2713269) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" CDS complement(2713247..2713936) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" gene complement(2713247..2713936) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" CDS complement(2713953..2715635) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" gene complement(2713953..2715635) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" CDS complement(2715649..2717139) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" gene complement(2715649..2717139) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" promotor_-10 complement(2717232..2717251) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717239) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" S_feature complement(2717241..2717316) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2717266..2717273) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2717317..2718288) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" gene complement(2717317..2718288) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" S_feature complement(2718289..2718417) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2718402..2718421) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2718417) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" promotor_-35 complement(2718436..2718439) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2718485..2719570) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" gene complement(2718485..2719570) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" downshifts complement(2718499) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(2719596..2719615) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2719619) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" promotor_-35 complement(2719630..2719637) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2719688..2719697 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2719703 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" promotor_-10 2719709..2719724 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2719754..2720146 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" gene 2719754..2720146 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" downshifts 2720117 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" S_feature 2720162..2720468 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2720162..2720431) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" gene complement(2720162..2720431) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" downshifts complement(2720178) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" downshifts complement(2720347) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" downshifts 2720425 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" CDS complement(2720488..2720847) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" gene complement(2720488..2720847) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" downshifts complement(2720501) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" CDS complement(2720879..2721079) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" gene complement(2720879..2721079) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" CDS complement(2721092..2721613) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" gene complement(2721092..2721613) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" misc_RNA complement(2721675..2721814) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" gene complement(2721675..2721814) /locus_tag="BSU_misc_RNA_47" promotor_-10 complement(2721811..2721830) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721821) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" S_feature complement(2721823..2721887) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2721844..2721851) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2721869..2721888) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721887) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" promotor_-35 complement(2721904..2721908) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2722006..2722013 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2722027..2722045 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2722027 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" CDS 2722059..2722724 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" gene 2722059..2722724 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" downshifts 2722702 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" CDS complement(2722756..2723451) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" gene complement(2722756..2723451) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" downshifts complement(2722778) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" downshifts complement(2722822) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" CDS complement(2723473..2723913) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" gene complement(2723473..2723913) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" promotor_-10 complement(2723935..2723954) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723954) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" promotor_-35 complement(2723970..2723973) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2724047..2724772) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" gene complement(2724047..2724772) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" downshifts complement(2724076) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" CDS complement(2724750..2726531) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" gene complement(2724750..2726531) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" promotor_-35 2726615..2726618 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2726627..2726646) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2726632) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2726633..2726652 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2726640 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" CDS 2726698..2727480 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" gene 2726698..2727480 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" downshifts 2727464 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" downshifts complement(2727514) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" CDS complement(2727521..2729452) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" gene complement(2727521..2729452) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" misc_RNA complement(2729496..2729743) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" gene complement(2729496..2729743) /gene="tboT" /locus_tag="BSU_misc_RNA_48" promotor_-10 complement(2729499..2729508) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729499) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" promotor_-35 complement(2729527) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2729554) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" promotor_-10 complement(2729754..2729773) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729767) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" S_feature complement(2729769..2729849) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2729789..2729793) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2729850..2730695) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" gene complement(2729850..2730695) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" promotor_-10 complement(2730715..2730733) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730721) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2730749..2730754) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2730774..2731415) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" gene complement(2730774..2731415) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" CDS complement(2731449..2732384) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" gene complement(2731449..2732384) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" CDS complement(2732412..2733830) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" gene complement(2732412..2733830) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" promotor_-10 complement(2733859..2733878) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733867) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2733893..2733896) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2733945..2734403) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" gene complement(2733945..2734403) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" downshifts complement(2733964) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" S_feature complement(2734404..2734551) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2734542..2734561) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2734551) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" S_feature complement(2734553..2734631) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2734576..2734579) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2734676) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" CDS complement(2734677..2735057) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" gene complement(2734677..2735057) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" S_feature complement(2735058..2735212) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2735192..2735211) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2735199 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 2735200..2735219 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2735212) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" promotor_-35 complement(2735226..2735232) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2735290..2735301) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2735296..2736318) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" gene complement(2735296..2736318) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" upshifts complement(2735297) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" promotor_-35 complement(2735316..2735322) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2736362..2736381) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736393) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" promotor_-35 complement(2736394..2736401) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2736524..2736904) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" gene complement(2736524..2736904) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" downshifts complement(2736548) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" S_feature complement(2736905..2737035) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2736960..2736964 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2736980..2736999 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2736981..2737087 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2736981 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" promotor_-10 complement(2737025..2737044) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737035) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" promotor_-35 complement(2737059..2737066) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2737088..2738278 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" gene 2737088..2738278 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" promotor_-10 complement(2737910..2737928) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737926) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2737944..2737949) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2738302..2739144 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" gene 2738302..2739144 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" promotor_-35 2738917..2738922 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2738938..2738956 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2738939 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2739137 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" downshifts complement(2739177) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" CDS complement(2739186..2739779) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" gene complement(2739186..2739779) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" CDS complement(2739795..2740427) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" gene complement(2739795..2740427) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" S_feature complement(2740428..2740592) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2740593..2741423) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" gene complement(2740593..2741423) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" CDS complement(2741446..2744088) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" gene complement(2741446..2744088) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" promotor_-10 complement(2744143..2744162) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2744152) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" promotor_-35 complement(2744176..2744183) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2744212..2744331) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2744255) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" CDS complement(2744332..2746071) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" gene complement(2744332..2746071) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" CDS complement(2746064..2746786) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" gene complement(2746064..2746786) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" promotor_-10 complement(2746854..2746873) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746864) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" S_feature complement(2746866..2746966) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2746887..2746893) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2746998..2747936) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" gene complement(2746998..2747936) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" downshifts complement(2747011) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" CDS complement(2747980..2749251) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" gene complement(2747980..2749251) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" misc_feature complement(2749036..2749055) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2749048) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" S_feature complement(2749252..2749334) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2749334) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" S_feature complement(2749336..2749414) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2749336..2749355) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2749371..2749375) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2749415..2750533) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" gene complement(2749415..2750533) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" downshifts 2750028 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" misc_feature 2750375..2750378 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2750383 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2750512 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2750534..2750740) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2750708..2750720 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2750719 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2750726..2750745) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750740) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" promotor_-35 complement(2750760..2750764) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2750860) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" CDS complement(2750867..2751331) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" gene complement(2750867..2751331) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" promotor_-10 complement(2751344..2751363) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751358) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" S_feature complement(2751360..2752545) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2751360..2751365 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2751376..2751384) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2751380..2751398 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2751386 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" CDS 2751428..2752543 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" gene 2751428..2752543 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" downshifts 2752514 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" CDS complement(2752576..2752959) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" gene complement(2752576..2752959) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" downshifts complement(2752590) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" S_feature complement(2752960..2753051) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2753052..2754809) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" gene complement(2753052..2754809) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" CDS complement(2754852..2755811) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" gene complement(2754852..2755811) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" S_feature complement(2755812..2755913) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2755902..2755921) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755913) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2755937..2755941) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2755995..2756972) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" gene complement(2755995..2756972) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" downshifts complement(2756022) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" CDS complement(2756957..2757829) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" gene complement(2756957..2757829) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" promotor_-35 2757791..2757796 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757812..2757830 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2757816..2758990 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2757816 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" S_feature complement(2757830..2757913) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2757902..2757921) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757913) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" S_feature complement(2757915..2758067) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2757937..2757941) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2758069..2758163) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2758112) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" CDS complement(2758164..2759396) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" gene complement(2758164..2759396) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" S_feature complement(2759397..2759513) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2759501..2759520) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2759513) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" CDS complement(2759533..2762880) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" gene complement(2759533..2762880) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" promotor_-35 complement(2759534..2759541) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2760545..2760554 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2760566..2760581 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760566 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2760754..2760773) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2760773) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" promotor_-35 complement(2760787..2760794) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2762911..2762930) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2762929) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" promotor_-35 complement(2762944..2762951) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2762969..2762974 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2762986 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" promotor_-10 2762990..2763008 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2763020..2763361 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" gene 2763020..2763361 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" CDS 2763358..2763861 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" gene 2763358..2763861 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" promotor_-35 2763894..2763897 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2763912..2763931 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2763912 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" CDS 2763963..2764154 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" gene 2763963..2764154 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" downshifts complement(2763964) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" downshifts 2764130 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" CDS complement(2764172..2765113) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" gene complement(2764172..2765113) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" S_feature 2764175..2764546 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2764207) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2764515..2764524 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764538..2764557 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2764548..2764942 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2764548 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-35 2764904..2764910 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764926..2764945 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2764944..2765243 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2764944 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" promotor_-10 complement(2765132..2765151) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765148) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" S_feature complement(2765150..2765564) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2765166..2765169) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2765244..2765546 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" gene 2765244..2765546 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" S_feature 2765547..2767342 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2765565..2766884) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" gene complement(2765565..2766884) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" promotor_-10 complement(2766910..2766929) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2766931) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" promotor_-35 complement(2766944..2766949) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2767060..2767962) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" gene complement(2767060..2767962) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" CDS complement(2767981..2769231) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" gene complement(2767981..2769231) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" CDS complement(2769249..2769941) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" gene complement(2769249..2769941) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" CDS complement(2769988..2771316) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" gene complement(2769988..2771316) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" CDS complement(2771313..2771594) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" gene complement(2771313..2771594) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" CDS complement(2771609..2772613) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" gene complement(2771609..2772613) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" CDS complement(2772610..2773389) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" gene complement(2772610..2773389) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" CDS complement(2773386..2774093) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" gene complement(2773386..2774093) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" CDS complement(2774123..2774842) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" gene complement(2774123..2774842) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" promotor_-35 2774668..2774675 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774690..2774709 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774690 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2774864..2775676) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" gene complement(2774864..2775676) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" CDS complement(2775690..2776499) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" gene complement(2775690..2776499) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" CDS complement(2776513..2777049) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" gene complement(2776513..2777049) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" promotor_-35 2777086..2777093 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2777104..2777123) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2777107..2777126 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2777110..2777201 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2777110 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" upshifts complement(2777120) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" promotor_-35 complement(2777137..2777144) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2777202..2778128 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" gene 2777202..2778128 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" S_feature complement(2777604..2778133) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2778178) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" CDS complement(2778179..2778862) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" gene complement(2778179..2778862) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" S_feature complement(2778863..2778924) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2778925..2779692) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" gene complement(2778925..2779692) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" promotor_-10 complement(2779737..2779756) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779759) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" promotor_-35 complement(2779772..2779774) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2779819..2780055) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" gene complement(2779819..2780055) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" downshifts 2779904 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" downshifts complement(2779924) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" CDS complement(2780015..2781400) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" gene complement(2780015..2781400) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" CDS complement(2781397..2782608) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" gene complement(2781397..2782608) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" S_feature complement(2782609..2782686) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2782679..2782698) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782685) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" promotor_-35 complement(2782713..2782720) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782778..2783290) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" gene complement(2782778..2783290) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" downshifts complement(2782796) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2783316..2783335) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2783324) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" promotor_-35 complement(2783349..2783356) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2783375..2784562) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" gene complement(2783375..2784562) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" downshifts complement(2783390) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" S_feature complement(2784563..2784667) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2784652..2784671) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784667) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" S_feature complement(2784669..2784798) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2784687..2784691) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784735..2784938) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" gene complement(2784735..2784938) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" promotor_-10 complement(2784796..2784807) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784798) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" promotor_-35 complement(2784822..2784828) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784910..2785899) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" gene complement(2784910..2785899) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" downshifts complement(2784928) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" CDS complement(2785960..2786463) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" gene complement(2785960..2786463) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" downshifts complement(2785966) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" promotor_no_box 2786180..2786280 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2786240 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2786459 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2786486..2786505) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2786502) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" promotor_-35 complement(2786519..2786526) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786573..2787028) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" gene complement(2786573..2787028) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" downshifts complement(2786601) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" CDS complement(2787042..2787722) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" gene complement(2787042..2787722) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" upshifts complement(2787134) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" promotor_-10 complement(2787141..2787152) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2787167..2787173) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2787460) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" promotor_-10 complement(2787735..2787753) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2787749) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" promotor_-35 complement(2787768..2787773) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2787797..2788291) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" gene complement(2787797..2788291) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" downshifts complement(2787812) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" CDS complement(2788304..2789311) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" gene complement(2788304..2789311) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" promotor_-10 complement(2789335..2789350) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2789352) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" S_feature complement(2789354..2789433) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2789362..2789371) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2789411..2789430 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2789421 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" promotor_-10 complement(2789426..2789445) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2789430..2789496 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2789433) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" promotor_-35 complement(2789461..2789465) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2789497..2790300 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" gene 2789497..2790300 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" downshifts 2790230 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" downshifts 2790288 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" CDS complement(2790332..2791921) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" gene complement(2790332..2791921) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" downshifts complement(2790341) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" CDS complement(2791941..2793530) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" gene complement(2791941..2793530) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" promotor_-10 complement(2793576..2793593) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2793581) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" promotor_-35 complement(2793609..2793615) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2793708) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" CDS complement(2793709..2793918) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" gene complement(2793709..2793918) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" promotor_-35 2793914..2793918 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2793918 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2793927..2793941 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2793939..2793950) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2793950) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" promotor_-35 complement(2793965..2793971) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794012..2795217) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" gene complement(2794012..2795217) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" CDS complement(2795221..2796366) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" gene complement(2795221..2796366) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" S_feature complement(2796367..2797510) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2796453..2796460 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2796471..2796560 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2796471 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" promotor_-10 2796473..2796492 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2796561..2797898 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" gene 2796561..2797898 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" promotor_-10 complement(2797496..2797515) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797510) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" promotor_-35 complement(2797530..2797537) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2797874 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" CDS complement(2797993..2799681) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" gene complement(2797993..2799681) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" downshifts complement(2797994) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" S_feature complement(2799682..2799787) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2799764..2799772 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2799775..2799794) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2799783..2799802 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799787) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" upshifts 2799787 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2799788..2799877 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2799789..2800348) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2799810..2799812) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2799878..2800684 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" gene 2799878..2800684 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" promotor_-10 complement(2800352..2800371) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800365) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" promotor_-35 complement(2800383..2800390) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2800634..2800680) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2800656) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" CDS complement(2800681..2801304) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" gene complement(2800681..2801304) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" S_feature 2800685..2801027 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2801005..2801012 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801027..2801046 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2801029..2801172 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2801029 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" promotor_-35 2801144..2801148 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801164..2801183 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2801174..2801304 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2801174 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" S_feature 2801306..2801430 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2801306 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" promotor_-10 complement(2801320..2801338) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2801322..2801341 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2801338) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" promotor_-35 complement(2801349..2801357) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2801431..2801922 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" gene 2801431..2801922 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" downshifts 2801901 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" CDS complement(2801960..2803699) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" gene complement(2801960..2803699) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" downshifts complement(2801978) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" promotor_-35 2803173..2803180 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2803194..2803212 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2803197 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" S_feature 2803199..2803794 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2803729..2803748) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2803737) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" S_feature complement(2803739..2804572) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2803775..2803782 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2803796..2803993 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2803796..2803815 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2803796 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" misc_RNA 2803853..2803985 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" gene 2803853..2803985 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" CDS 2803994..2804596 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" gene 2803994..2804596 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" downshifts 2804519 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" S_feature complement(2804574..2804793) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2804582 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" downshifts complement(2804617) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" downshifts 2804629 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" S_feature 2804674..2804847 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2804789..2804807) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804801) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" downshifts 2804805 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(2804822..2804828) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2804867..2806135) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" gene complement(2804867..2806135) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" downshifts complement(2804893) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" misc_RNA complement(2806159..2806432) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" gene complement(2806159..2806432) /gene="tboY" /locus_tag="BSU_misc_RNA_83" S_feature complement(2806180..2806323) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2806223) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" promotor_-10 complement(2806430..2806449) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2806442) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2806462..2806469) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2806477..2808195) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" gene complement(2806477..2808195) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" promotor_-35 2808209..2808216 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2808223..2808242) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2808231..2808250 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808237 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2808246) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" promotor_-35 complement(2808256..2808262) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2808279..2808286 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808300..2808319 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808303 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" CDS 2808356..2808988 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" gene 2808356..2808988 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" promotor_-35 2808561..2808569 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808583..2808602 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808589 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" CDS 2809015..2809659 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" gene 2809015..2809659 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" CDS 2809656..2810819 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" gene 2809656..2810819 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" downshifts 2810810 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" CDS complement(2810830..2811558) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" gene complement(2810830..2811558) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" downshifts complement(2810866) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" CDS complement(2811548..2812366) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" gene complement(2811548..2812366) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" CDS complement(2812429..2813433) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" gene complement(2812429..2813433) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" downshifts complement(2812446) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" misc_feature complement(2813468..2813487) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2813483) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" S_feature complement(2813485..2813593) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2813593..2813612) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813593) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" S_feature complement(2813595..2813660) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2813626..2813632) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2813706) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" CDS complement(2813709..2814785) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" gene complement(2813709..2814785) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" promotor_-10 complement(2814826..2814845) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2814846) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" S_feature complement(2814848..2814948) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2814860..2814867) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2814882 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" promotor_-10 complement(2814936..2814955) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814948) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" promotor_-35 complement(2814969..2814975) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2815021..2815347) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" gene complement(2815021..2815347) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" downshifts complement(2815030) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" CDS complement(2815371..2815826) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" gene complement(2815371..2815826) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" CDS complement(2815857..2816279) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" gene complement(2815857..2816279) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" promotor_-10 complement(2816300..2816318) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816313) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" promotor_-35 complement(2816332..2816338) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2816352..2816370) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2816361) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" promotor_-35 complement(2816381..2816389) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2816441..2817739) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" gene complement(2816441..2817739) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" downshifts complement(2816450) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(2817764..2817783) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817765) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" S_feature complement(2817767..2817963) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2817796..2817805) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2817946..2817965) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817963) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" promotor_-35 complement(2817977..2817983) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817989..2820847) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" gene complement(2817989..2820847) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" promotor_-10 complement(2820881..2820900) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2820891) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" promotor_-35 complement(2820916..2820920) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2820990) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" CDS complement(2821007..2821612) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" gene complement(2821007..2821612) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" CDS complement(2821628..2822437) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" gene complement(2821628..2822437) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" CDS complement(2822452..2822775) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" gene complement(2822452..2822775) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" S_feature complement(2822776..2822914) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2822814..2822930) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" gene complement(2822814..2822930) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" promotor_-10 complement(2822901..2822920) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2822914) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" promotor_-35 2822922..2822929 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2822936) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-35" promotor_-10 2822944..2822963 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2822949 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" CDS 2823010..2823456 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" gene 2823010..2823456 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" S_feature 2823457..2824185 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2823511..2824584) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" gene complement(2823511..2824584) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" downshifts complement(2823530) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2824606..2824625) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824610) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" promotor_-35 complement(2824639..2824646) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2824681..2824684 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2824699..2824718 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2824704 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" CDS 2824743..2825060 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" gene 2824743..2825060 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" downshifts 2825060 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" CDS complement(2825113..2826813) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" gene complement(2825113..2826813) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" downshifts complement(2825132) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(2826845..2826863) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826852) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" promotor_-35 complement(2826878..2826884) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2826895..2827665) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" gene complement(2826895..2827665) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" S_feature complement(2827666..2827754) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2827752..2827771) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827754) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" promotor_-35 complement(2827787..2827791) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2827811..2828452) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" gene complement(2827811..2828452) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" downshifts complement(2827821) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" downshifts complement(2827886) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(2828478..2828497) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2828487) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" S_feature complement(2828489..2828937) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2828513..2828517) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2828596..2828602 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2828617..2828628 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2828624 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" CDS 2828659..2828937 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" gene 2828659..2828937 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" S_feature 2828938..2829108 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2828938..2829552) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" gene complement(2828938..2829552) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" downshifts 2829086 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" S_feature complement(2829553..2829888) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2829880..2829899) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2829888) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" promotor_-35 complement(2829914..2829921) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2829915..2832071) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" gene complement(2829915..2832071) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" CDS complement(2832097..2833026) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" gene complement(2832097..2833026) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" CDS complement(2833075..2833989) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" gene complement(2833075..2833989) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" promotor_-10 complement(2833752..2833770) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2833760) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2833784..2833790) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2834015..2834566) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" gene complement(2834015..2834566) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" misc_feature 2834429..2834448 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2834432 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2834589..2834608) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2834601) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" promotor_-35 complement(2834624..2834627) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2834649..2834656 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2834667..2834686 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2834670..2834681) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2834674 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" upshifts complement(2834684) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" promotor_-35 complement(2834695..2834701) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2834715..2835650 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" gene 2834715..2835650 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" downshifts 2835626 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" CDS complement(2835684..2837075) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" gene complement(2835684..2837075) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" downshifts complement(2835696) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" S_feature complement(2837076..2837516) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2837102..2837107 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837121..2837140 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837134 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" CDS 2837172..2838470 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" gene 2837172..2838470 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" promotor_-10 complement(2837493..2837512) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837516) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" promotor_-35 complement(2837527..2837533) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2838457 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" CDS complement(2838510..2839667) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" gene complement(2838510..2839667) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" downshifts complement(2838535) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" promotor_-35 2838783..2838788 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838803..2838821 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838811 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2839664..2840374) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" gene complement(2839664..2840374) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" promotor_-10 complement(2840388..2840403) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2840405) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" promotor_-35 complement(2840415..2840424) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2840431..2840432 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2840444..2840549 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2840444 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" promotor_-10 2840452..2840462 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2840515..2840521 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2840536..2840555 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2840551..2840664 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2840551 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" CDS 2840665..2840886 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" gene 2840665..2840886 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" downshifts 2840869 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" downshifts 2840938 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" CDS complement(2841007..2841726) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" gene complement(2841007..2841726) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" downshifts complement(2841021) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" downshifts complement(2841792) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" CDS complement(2841795..2843429) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" gene complement(2841795..2843429) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" misc_feature complement(2843461..2843480) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2843477) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" promotor_-35 2843547..2843551 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843567..2843586 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843585 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" CDS 2843631..2844893 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" gene 2843631..2844893 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" S_feature 2844894..2844992 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2844966..2844972 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844988..2845006 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2844994..2845081 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2844994 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" CDS 2845082..2846620 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" gene 2845082..2846620 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" downshifts 2846600 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" CDS complement(2846657..2846839) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" gene complement(2846657..2846839) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" downshifts complement(2846676) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2846854..2846872) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2846874) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" promotor_-35 complement(2846888..2846893) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2846907..2847575) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" gene complement(2846907..2847575) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" CDS complement(2847597..2848883) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" gene complement(2847597..2848883) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" CDS complement(2848895..2849398) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" gene complement(2848895..2849398) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" CDS complement(2849395..2850516) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" gene complement(2849395..2850516) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" CDS complement(2850524..2851489) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" gene complement(2850524..2851489) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" upshifts complement(2851515) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" promotor_-10 complement(2851516..2851535) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2851550..2851557) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2851645..2851652 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2851665 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" promotor_-10 2851668..2851687 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2851705..2854023 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" gene 2851705..2854023 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" downshifts 2854013 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" CDS complement(2854064..2855560) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" gene complement(2854064..2855560) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" downshifts complement(2854066) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" CDS complement(2855585..2856445) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" gene complement(2855585..2856445) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" promotor_-10 complement(2856521..2856540) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2856530) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" promotor_-35 complement(2856556..2856563) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2856652..2857413) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" gene complement(2856652..2857413) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" downshifts complement(2856681) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" S_feature complement(2857414..2857489) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2857490..2858677) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" gene complement(2857490..2858677) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" CDS complement(2858746..2859753) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" gene complement(2858746..2859753) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" CDS complement(2859756..2860451) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" gene complement(2859756..2860451) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" CDS complement(2860448..2861617) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" gene complement(2860448..2861617) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" promotor_-35 2860484..2860491 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860506..2860525 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860524 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(2861607..2862953) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" gene complement(2861607..2862953) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" promotor_-35 2862023..2862027 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2862042 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2862043..2862061 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2862943..2863719) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" gene complement(2862943..2863719) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" S_feature complement(2863720..2863812) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2863798..2863817) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2863812) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" promotor_-35 complement(2863832..2863839) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2863929..2864828) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" gene complement(2863929..2864828) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" promotor_-10 complement(2864851..2864869) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864868) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2864880..2864888) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2864958..2864965 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2864981..2865000 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2864987 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2865046..2866080 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" gene 2865046..2866080 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" promotor_-35 2866029..2866036 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2866051..2866059 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2866068 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" CDS 2866114..2867394 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" gene 2866114..2867394 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" CDS 2867387..2868298 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" gene 2867387..2868298 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" CDS 2868295..2869125 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" gene 2868295..2869125 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" promotor_-35 2869098..2869102 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2869118..2869137 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2869126 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2869145..2870443 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" gene 2869145..2870443 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" downshifts 2870424 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" CDS complement(2870465..2870776) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" gene complement(2870465..2870776) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" downshifts complement(2870476) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(2870800..2870819) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870808) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" promotor_-35 complement(2870834..2870841) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2870842 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" CDS complement(2870893..2873307) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" gene complement(2870893..2873307) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" downshifts complement(2870897) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" S_feature complement(2873308..2873403) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2873417..2873631) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" gene complement(2873417..2873631) /gene="tboL" /locus_tag="BSU_misc_RNA_49" downshifts complement(2873448) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2873643..2873662) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873664) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" promotor_-35 2873668..2873673 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2873677..2873682) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2873689..2873707 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2873702..2874142 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2873702 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" CDS complement(2873734..2874069) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" gene complement(2873734..2874069) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" S_feature complement(2874064..2874328) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2874313..2874332) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2874328) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" promotor_-35 complement(2874347..2874354) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2874367..2874374 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2874388..2874407 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2874404 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" S_feature 2874406..2874473 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2874474..2875259 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" gene 2874474..2875259 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" S_feature 2875260..2875316 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2875496..2876689) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" gene complement(2875496..2876689) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" downshifts complement(2875516) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" S_feature complement(2876690..2876788) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2876769..2876788) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2876788) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" promotor_-35 complement(2876802..2876809) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2876826..2876829 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876844..2876863 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2876848 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" CDS 2876878..2877624 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" gene 2876878..2877624 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" downshifts 2877519 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" downshifts 2877618 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" CDS complement(2877661..2879601) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" gene complement(2877661..2879601) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" downshifts complement(2877672) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" CDS complement(2879591..2880352) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" gene complement(2879591..2880352) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" misc_feature complement(2880376..2880394) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2880395) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" CDS complement(2880454..2881458) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" gene complement(2880454..2881458) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" downshifts complement(2880493) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" CDS complement(2881451..2882146) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" gene complement(2881451..2882146) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" promotor_-10 complement(2882170..2882188) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882182) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2882204..2882207) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2882243..2883553) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" gene complement(2882243..2883553) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" downshifts complement(2882265) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" CDS complement(2883543..2884238) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" gene complement(2883543..2884238) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" CDS complement(2884253..2885230) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" gene complement(2884253..2885230) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" CDS complement(2885260..2886246) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" gene complement(2885260..2886246) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" promotor_-35 2886116..2886125 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2886132 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2886138..2886153 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2886240..2887118) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" gene complement(2886240..2887118) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" CDS complement(2887111..2887503) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" gene complement(2887111..2887503) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" S_feature complement(2887504..2887748) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2887537..2887674) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" gene complement(2887537..2887674) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" downshifts 2887672 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" promotor_-10 complement(2887743..2887762) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2887748) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" promotor_-35 complement(2887776..2887783) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2887829..2888101) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" gene complement(2887829..2888101) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" downshifts complement(2887836) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2888141..2888152) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2888145..2888153 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2888145) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" upshifts 2888156 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" promotor_-10 2888167..2888185 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2888167..2888173) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2888196..2888201 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2888215..2888234 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2888222 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" CDS 2888263..2889231 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" gene 2888263..2889231 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" CDS 2889228..2889812 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" gene 2889228..2889812 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" downshifts 2889776 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" CDS complement(2889802..2890905) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" gene complement(2889802..2890905) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" downshifts complement(2889843) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" CDS complement(2890926..2891705) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" gene complement(2890926..2891705) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" promotor_-35 2891348..2891355 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2891370..2891389 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2891387 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" S_feature complement(2891706..2892285) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2891754..2892269 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" gene 2891754..2892269 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" promotor_-10 complement(2892276..2892295) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892285) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" S_feature complement(2892287..2892421) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2892307..2892314) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2892396..2892415) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2892421) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" CDS complement(2892514..2893905) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" gene complement(2892514..2893905) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" downshifts complement(2892522) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" S_feature complement(2893906..2894040) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2894041..2895939) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" gene complement(2894041..2895939) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" promotor_-35 2895097..2895103 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2895118..2895129 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2895130 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2895940..2896063) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2896089..2897291) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" gene complement(2896089..2897291) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" downshifts complement(2896108) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" promotor_-10 complement(2897334..2897345) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897340) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" S_feature complement(2897342..2897458) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2897359..2897365) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2897459..2897597) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(2897459..2897597) /gene="mswG" /locus_tag="BSU_misc_RNA_50" downshifts 2897557 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" promotor_-10 complement(2897606..2897625) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2897621) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" promotor_-35 complement(2897642..2897646) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2897718..2897725 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2897737 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" promotor_-10 2897739..2897758 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2897794..2899377 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" gene 2897794..2899377 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" downshifts 2899366 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" CDS complement(2899416..2899658) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" gene complement(2899416..2899658) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" downshifts complement(2899430) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" CDS complement(2899710..2900483) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" gene complement(2899710..2900483) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" S_feature complement(2900484..2900574) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2900550..2900559 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2900563..2900582) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900571 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" promotor_-10 2900572..2900591 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900576) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" promotor_-35 complement(2900597..2900604) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2900634..2901638 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" gene 2900634..2901638 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" CDS 2901651..2902433 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" gene 2901651..2902433 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" S_feature complement(2901655..2903203) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2902408..2903220 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" gene 2902408..2903220 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" downshifts 2903205 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" CDS complement(2903247..2903723) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" gene complement(2903247..2903723) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" downshifts complement(2903248) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" misc_feature complement(2903753..2903772) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2903766) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" S_feature complement(2903768..2903902) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2903902) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" promotor_-10 complement(2903904..2903915) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2903930..2903936) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2903932..2904336) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" gene complement(2903932..2904336) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" promotor_-10 complement(2904364..2904383) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904381) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2904383..2904469) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2904396..2904405) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2904502..2904939) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" gene complement(2904502..2904939) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" downshifts complement(2904514) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2904956..2904974) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904974) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" S_feature complement(2904976..2905201) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2904989..2904995) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2905031..2905050 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2905032..2905208 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" gene 2905032..2905208 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" upshifts 2905033 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" CDS complement(2905202..2905639) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" gene complement(2905202..2905639) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" downshifts 2905228 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(2905658..2905677) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2905679) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" promotor_-35 complement(2905688..2905696) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2905759..2906232) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" gene complement(2905759..2906232) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" downshifts complement(2905768) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" downshifts complement(2905855) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" S_feature complement(2906233..2906584) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2906304..2906311 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906324..2906343 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906329 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 2906361..2906588 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" gene 2906361..2906588 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" CDS complement(2906585..2907148) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" gene complement(2906585..2907148) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" misc_feature complement(2907173..2907192) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2907188) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" CDS complement(2907242..2907490) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" gene complement(2907242..2907490) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" downshifts complement(2907263) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" promotor_-10 complement(2907518..2907537) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2907551..2907558) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2907555) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" promotor_-35 2907617..2907623 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2907637..2907648 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2907649 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" CDS 2907695..2909026 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" gene 2907695..2909026 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" CDS 2909070..2910110 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" gene 2909070..2910110 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" promotor_-35 2910104..2910110 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2910125..2910136 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2910135 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" CDS 2910164..2910322 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" gene 2910164..2910322 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" downshifts 2910311 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" CDS complement(2910341..2911228) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" gene complement(2910341..2911228) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" downshifts complement(2910364) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" CDS complement(2911218..2912525) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" gene complement(2911218..2912525) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" CDS complement(2912531..2913283) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" gene complement(2912531..2913283) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" CDS complement(2913302..2914222) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" gene complement(2913302..2914222) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" promotor_-10 complement(2914258..2914269) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2914259) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(2914261..2914352) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2914283..2914289) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2914337 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(2914338..2914357) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2914340..2914352 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2914352) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" S_feature complement(2914354..2914435) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2914372..2914379) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2914435) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" promotor_-10 complement(2914444..2914463) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2914477..2914484) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2914502..2915617) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" gene complement(2914502..2915617) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" downshifts complement(2914545) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" CDS complement(2915614..2917074) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" gene complement(2915614..2917074) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" promotor_-10 complement(2916517..2916535) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916521) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" promotor_-35 complement(2916550..2916556) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2917163) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" CDS complement(2917165..2917980) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" gene complement(2917165..2917980) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" CDS complement(2918015..2918839) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" gene complement(2918015..2918839) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" promotor_-10 complement(2918097..2918116) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918097) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" promotor_-35 complement(2918132..2918135) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2918263) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" promotor_-10 complement(2918273..2918284) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2918299..2918305) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2918827..2920569) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" gene complement(2918827..2920569) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" CDS complement(2920566..2921981) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" gene complement(2920566..2921981) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" S_feature complement(2921982..2922094) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2922074..2922093) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2922094) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" S_feature complement(2922096..2922246) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2922109..2922112) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2922207..2922213 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2922227..2922246) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2922227..2922238 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2922235 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" upshifts complement(2922246) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" promotor_-35 complement(2922260..2922269) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2922271..2922990 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" gene 2922271..2922990 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" S_feature complement(2922341..2922998) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2922979 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" CDS complement(2922999..2923817) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" gene complement(2922999..2923817) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" promotor_-10 complement(2923838..2923857) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923852) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" promotor_-35 complement(2923872..2923880) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2923918..2923926 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923939..2923958 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923940 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" CDS 2923989..2925275 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" gene 2923989..2925275 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" CDS 2925272..2926222 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" gene 2925272..2926222 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" CDS 2926225..2927448 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" gene 2926225..2927448 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" downshifts complement(2927372) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" S_feature 2927449..2928016 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2927522..2927953) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" gene complement(2927522..2927953) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" downshifts complement(2927548) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" CDS complement(2927955..2929010) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" gene complement(2927955..2929010) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" CDS complement(2929025..2930158) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" gene complement(2929025..2930158) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" promotor_-10 complement(2930191..2930210) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2930210) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" promotor_-35 complement(2930223..2930232) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2930296..2930305 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2930319..2930338 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2930321 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" CDS 2930348..2931421 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" gene 2930348..2931421 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" promotor_-35 2930645..2930651 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2930662 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2930665..2930676 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2931410 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" promotor_-35 2931448..2931454 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2931469 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" promotor_-10 2931470..2931488 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2931501..2931968 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" gene 2931501..2931968 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" downshifts 2931940 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" CDS complement(2931999..2934395) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" gene complement(2931999..2934395) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" downshifts complement(2932014) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" CDS complement(2934382..2935836) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" gene complement(2934382..2935836) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" CDS complement(2935833..2936864) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" gene complement(2935833..2936864) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" CDS complement(2936888..2938030) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" gene complement(2936888..2938030) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" CDS complement(2938027..2939910) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" gene complement(2938027..2939910) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" S_feature 2938736..2940155 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2939942..2939957) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939955) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" promotor_-35 complement(2939972..2939977) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2940022) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" tRNA complement(2940143..2940214) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940143..2940214) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" tRNA complement(2940240..2940330) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940240..2940330) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" tRNA complement(2940334..2940408) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940334..2940408) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" tRNA complement(2940419..2940495) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940419..2940495) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" tRNA complement(2940511..2940584) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940511..2940584) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" tRNA complement(2940595..2940670) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940595..2940670) /gene="trnB-His" /locus_tag="BSU_tRNA_67" tRNA complement(2940688..2940763) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940688..2940763) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" tRNA complement(2940776..2940852) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940776..2940852) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" tRNA complement(2940864..2940940) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940864..2940940) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" tRNA complement(2940958..2941050) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2940958..2941050) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" tRNA complement(2941057..2941133) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941057..2941133) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" tRNA complement(2941136..2941212) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941136..2941212) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" tRNA complement(2941232..2941304) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941232..2941304) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" tRNA complement(2941310..2941386) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941310..2941386) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" tRNA complement(2941402..2941478) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941402..2941478) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" tRNA complement(2941488..2941573) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941488..2941573) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" tRNA complement(2941588..2941662) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941588..2941662) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" tRNA complement(2941668..2941754) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941668..2941754) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" tRNA complement(2941765..2941840) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941765..2941840) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" tRNA complement(2941878..2941953) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941878..2941953) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" tRNA complement(2941986..2942061) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2941986..2942061) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" rRNA complement(2942082..2942199) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2942082..2942199) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" rRNA complement(2942255..2945182) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2942255..2945182) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" rRNA complement(2945350..2946904) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(2945350..2946904) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" S_feature complement(2946905..2947196) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2947032..2947040 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2947038 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2947148 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2947169..2947188) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947196) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" S_feature complement(2947198..2948164) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2947202..2947209) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2947321..2947324 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2947336 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" promotor_-10 2947339..2947358 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2947369..2947470 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" gene 2947369..2947470 /gene="tswC" /locus_tag="BSU_misc_RNA_51" downshifts 2947469 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" CDS 2947570..2948148 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" gene 2947570..2948148 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" downshifts 2948138 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" CDS complement(2948190..2948711) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" gene complement(2948190..2948711) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" downshifts complement(2948208) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" downshifts complement(2948280) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" CDS complement(2948729..2950258) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" gene complement(2948729..2950258) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" CDS complement(2950279..2950803) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" gene complement(2950279..2950803) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" promotor_-10 complement(2950847..2950862) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2950853) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" S_feature complement(2950855..2950942) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2950874..2950883) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2950927..2950945) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2950937 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" misc_feature 2950941..2950960 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2950942) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" promotor_-35 complement(2950960..2950965) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2950971..2951459 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" gene 2950971..2951459 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" downshifts 2951436 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" CDS complement(2951465..2952043) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" gene complement(2951465..2952043) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" S_feature 2951481..2951872 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2951492) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2952077..2952096) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952086) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" promotor_-35 complement(2952110..2952117) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2952131..2953339) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" gene complement(2952131..2953339) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" downshifts complement(2952152) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" promotor_-10 complement(2953108..2953127) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2953120) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2953142..2953149) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2953356..2954828) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" gene complement(2953356..2954828) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" promotor_-10 complement(2954879..2954898) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954880) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" promotor_-35 complement(2954913..2954920) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2954940..2954946 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2954960..2954979 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2954975 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" CDS 2955027..2955569 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" gene 2955027..2955569 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" downshifts 2955552 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" promotor_-35 2955646..2955653 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2955666..2955766 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2955666 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" promotor_-10 2955668..2955687 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2955767..2956312 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" gene 2955767..2956312 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" downshifts 2956299 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" promotor_-35 2956404..2956411 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2956425..2956444 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2956432 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" misc_RNA 2956437..2956605 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" gene 2956437..2956605 /gene="swdA" /locus_tag="BSU_misc_RNA_52" downshifts 2956586 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" CDS 2956678..2957346 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" gene 2956678..2957346 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" CDS 2957353..2958690 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" gene 2957353..2958690 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" downshifts 2958676 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" CDS complement(2958726..2958989) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" gene complement(2958726..2958989) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" downshifts complement(2958744) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" promotor_-10 complement(2959029..2959048) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959031) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" promotor_-35 complement(2959061..2959068) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2959098..2959946) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" gene complement(2959098..2959946) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" promotor_-10 complement(2959991..2960010) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2960001) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" promotor_-35 complement(2960025..2960032) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2960107..2961642) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" gene complement(2960107..2961642) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" downshifts complement(2960116) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" promotor_no_box 2961300..2961400 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2961360 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 2961426 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" S_feature complement(2961643..2961810) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2961799..2961818) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2961810) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" S_feature complement(2961812..2962689) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2961833..2961840) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2962052..2962061 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962075..2962094 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962075 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" CDS 2962127..2962612 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" gene 2962127..2962612 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" S_feature 2962613..2962899 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2962719..2962791) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" gene complement(2962719..2962791) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" downshifts complement(2962734) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" downshifts complement(2962778) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" promotor_-10 complement(2962802..2962821) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962822) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" promotor_-35 complement(2962836..2962839) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2962856 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" CDS complement(2962899..2963729) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" gene complement(2962899..2963729) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" downshifts complement(2962910) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" S_feature complement(2963730..2963821) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2963822..2964988) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" gene complement(2963822..2964988) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" promotor_-35 2964984..2964988 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964996..2965010 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2965012..2965031) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2965012 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(2965031) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" promotor_-35 complement(2965045..2965052) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2965110..2965117 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2965123 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" promotor_-10 2965128..2965147 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2965170..2966156 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" gene 2965170..2966156 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" downshifts 2966127 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" CDS complement(2966197..2967471) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" gene complement(2966197..2967471) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" downshifts complement(2966210) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" CDS complement(2967497..2967811) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" gene complement(2967497..2967811) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" CDS complement(2967829..2969286) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" gene complement(2967829..2969286) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" CDS complement(2969291..2970067) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" gene complement(2969291..2970067) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" misc_feature complement(2970101..2970120) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2970117) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" CDS complement(2970124..2972193) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" gene complement(2970124..2972193) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" promotor_-10 complement(2972226..2972245) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2972238) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" promotor_-35 complement(2972259..2972265) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2972331..2974319) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" gene complement(2972331..2974319) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" downshifts complement(2972350) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" promotor_-35 2974323..2974330 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2974340..2974358) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2974346..2974365 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974353) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" upshifts 2974362 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2974372..2974379) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2974428 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" CDS complement(2974433..2976418) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" gene complement(2974433..2976418) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" downshifts complement(2974438) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" promotor_-10 complement(2976439..2976457) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2976454) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" S_feature complement(2976456..2976543) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2976471..2976478) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2976544..2978532) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" gene complement(2976544..2978532) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" promotor_-10 complement(2978557..2978575) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2978572) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" promotor_-35 complement(2978589..2978596) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2978709..2980697) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" gene complement(2978709..2980697) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" downshifts complement(2978728) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" promotor_-10 complement(2980718..2980736) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980739) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" promotor_-35 complement(2980749..2980756) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2980799..2980808 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2980822..2980841 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2980825 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" CDS 2980855..2981592 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" gene 2980855..2981592 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" promotor_-10 complement(2980880..2980899) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2980888) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" promotor_-35 complement(2980915..2980919) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2981593..2984413 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2981606..2981860) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" gene complement(2981606..2981860) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" downshifts complement(2981632) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" S_feature complement(2981861..2982117) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2982118..2982516) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" gene complement(2982118..2982516) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" CDS complement(2982476..2982610) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" gene complement(2982476..2982610) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" promotor_-10 complement(2982559..2982578) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2982566) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" promotor_-35 complement(2982593..2982599) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2982636..2984300) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" gene complement(2982636..2984300) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" downshifts complement(2982652) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(2983608..2983627) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2983613) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(2983641..2983648) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2984325..2984343) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984342) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" promotor_-35 complement(2984359..2984364) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984427..2985716) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" gene complement(2984427..2985716) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" downshifts complement(2984436) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" promotor_-35 2985245..2985251 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2985265..2985283 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2985271 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" S_feature 2985275..2985927 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2985760..2986437) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" gene complement(2985760..2986437) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" downshifts complement(2985770) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" S_feature 2986112..2986788 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2986472..2986491) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2986479..2986742) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" gene complement(2986479..2986742) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" upshifts complement(2986493) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2986505..2986512) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2986754..2986772) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2986768) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" promotor_-35 complement(2986788..2986793) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2986789..2987121 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" gene 2986789..2987121 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" promotor_-35 2986806..2986812 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986827..2986844 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986838 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" CDS 2987118..2988104 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" gene 2987118..2988104 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" downshifts complement(2988079) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" CDS complement(2988101..2988505) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" gene complement(2988101..2988505) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" S_feature complement(2988506..2988564) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2988565..2988936) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" gene complement(2988565..2988936) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" CDS complement(2988995..2990347) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" gene complement(2988995..2990347) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" downshifts complement(2989006) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" promotor_-10 complement(2989162..2989180) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2989179) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" promotor_-35 complement(2989196..2989201) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2990320) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" misc_feature complement(2990323..2990334) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2990379..2990398) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990385) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" S_feature complement(2990387..2990458) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2990413..2990416) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2990459..2991631) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" gene complement(2990459..2991631) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" S_feature 2990794..2991715 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2991664..2991683) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2991677) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" promotor_-35 complement(2991700..2991703) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2991735..2992898) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" gene complement(2991735..2992898) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" downshifts complement(2991750) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(2992913..2992932) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2992931) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" S_feature complement(2992933..2993088) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2992947..2992954) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2992984..2992990 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2993005..2993023 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993015 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" S_feature 2993016..2993074 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2993061..2993067 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2993063..2993074) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993076 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" promotor_-10 2993081..2993092 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2993088..2993094) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2993088) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" S_feature complement(2993090..2993401) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2993128..2993364 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" gene 2993128..2993364 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" downshifts 2993324 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" downshifts 2993390 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" CDS complement(2993442..2993834) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" gene complement(2993442..2993834) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" downshifts complement(2993446) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(2993876..2993895) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2993883) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" S_feature complement(2993885..2994035) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2993911..2993915) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2993938..2993944 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2993951..2994935 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2993951 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" promotor_-10 2993959..2993977 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2994036..2995196) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" gene complement(2994036..2995196) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" promotor_-35 2995088..2995094 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2995106 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 2995108..2995112 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2995197..2995697) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" gene complement(2995197..2995697) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" promotor_-10 complement(2995727..2995746) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2995733..2995739 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2995748) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" promotor_-10 2995754..2995765 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2995754 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" promotor_-35 complement(2995757..2995764) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2995766..2995844 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2995845..2996666 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" gene 2995845..2996666 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" downshifts 2996646 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" downshifts complement(2996693) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" CDS complement(2996695..2996955) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" gene complement(2996695..2996955) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" promotor_-35 2996945..2996948 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2996963..2996982 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2996975 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" S_feature 2996976..2997041 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2996981..2997000) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2996986) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" promotor_-35 complement(2997012..2997018) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2997042..2998205 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" gene 2997042..2998205 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" promotor_-35 2998268..2998274 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998286..2998305 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998296 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" CDS 2998331..2999617 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" gene 2998331..2999617 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" S_feature complement(2999333..3000075) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2999612..2999619 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999633..2999652 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999634 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" CDS 2999663..3000049 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" gene 2999663..3000049 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" downshifts 3000031 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" CDS complement(3000076..3000693) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" gene complement(3000076..3000693) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" promotor_-10 complement(3000728..3000746) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000745) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" S_feature complement(3000747..3002835) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(3000761..3000766) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3000809..3000812 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 3000827..3000846 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 3000838 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" CDS 3000904..3002082 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" gene 3000904..3002082 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" promotor_-35 3002120..3002126 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3002138..3002157 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3002143 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" CDS 3002175..3004049 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" gene 3002175..3004049 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" promotor_-10 complement(3002815..3002834) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002835) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" promotor_-35 complement(3002848..3002857) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3004070..3004483 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" gene 3004070..3004483 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" downshifts 3004475 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" CDS complement(3004686..3005243) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" gene complement(3004686..3005243) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" misc_feature 3004707..3004726 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3004717 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" downshifts complement(3004727) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" S_feature 3004739..3005420 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(3005269..3005288) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005277) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" promotor_-35 complement(3005304..3005308) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3005421..3007022 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" gene 3005421..3007022 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" CDS 3007015..3007722 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" gene 3007015..3007722 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" downshifts 3007707 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" promotor_-35 3007886..3007893 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3007904..3008193 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 3007904 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" promotor_-10 3007908..3007927 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3008194..3009273 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" gene 3008194..3009273 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" CDS 3009349..3010881 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" gene 3009349..3010881 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" CDS 3010874..3011920 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" gene 3010874..3011920 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" CDS 3011921..3012880 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" gene 3011921..3012880 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" S_feature 3012881..3013002 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 3012975..3012978 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012993..3013012 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3013004 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" CDS 3013034..3014380 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" gene 3013034..3014380 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" downshifts 3014363 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" CDS complement(3014416..3014631) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" gene complement(3014416..3014631) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" promotor_-35 3014571..3014577 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014591..3014602 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014595 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3014642..3014660) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014649) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" promotor_-35 3014674..3014681 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3014676..3014681) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3014696..3014791 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 3014696..3014715 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014696 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" promotor_-35 3014754..3014758 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014774..3014793 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3014793..3014942 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 3014793 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3014862..3017267 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" gene 3014862..3017267 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" CDS 3017260..3017691 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" gene 3017260..3017691 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" CDS 3017691..3018032 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" gene 3017691..3018032 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" promotor_no_box 3017923..3018023 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3017983 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" CDS 3018025..3019506 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" gene 3018025..3019506 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" S_feature complement(3018758..3020626) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 3019512..3019988 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" gene 3019512..3019988 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" CDS 3019988..3020272 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" gene 3019988..3020272 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" CDS 3020256..3020630 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" gene 3020256..3020630 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" downshifts 3020601 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" CDS complement(3020669..3021049) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" gene complement(3020669..3021049) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" downshifts complement(3020671) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" CDS complement(3021068..3021712) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" gene complement(3021068..3021712) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" S_feature complement(3021713..3021792) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(3021793..3024102) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" gene complement(3021793..3024102) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" promotor_-35 3022787..3022794 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022808..3022827 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022823 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature 3023696..3024668 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 3023696 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" misc_feature 3023708..3023724 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3024117..3024284) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" gene complement(3024117..3024284) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" CDS complement(3024272..3025171) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKELIKECLLSYTKGDTRCKT*" gene complement(3024272..3025171) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" S_feature complement(3025172..3025285) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(3025279..3025298) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025285) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" promotor_-35 complement(3025312..3025318) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025356..3025496) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" gene complement(3025356..3025496) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" downshifts complement(3025385) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" S_feature complement(3025497..3025583) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(3025567..3025586) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025583) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" promotor_-35 complement(3025600..3025606) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3025683..3025701) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025693) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3025716..3025722) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3025718..3025843 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" gene 3025718..3025843 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" S_feature complement(3025871..3026300) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 3025896..3025901 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3025913) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" promotor_-10 3025916..3025934 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025918 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" CDS 3025957..3026325 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" gene 3025957..3026325 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" CDS complement(3026301..3027530) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" gene complement(3026301..3027530) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" S_feature 3026326..3027639 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(3027565..3027584) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3027584) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" downshifts 3027597 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3027599..3027606) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3027667..3029139) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" gene complement(3027667..3029139) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" downshifts complement(3027677) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" misc_feature 3029020..3029024 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3029027 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3029137 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" CDS complement(3029155..3029706) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" gene complement(3029155..3029706) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" promotor_-10 complement(3029728..3029747) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3029741) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3029760..3029767) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3029803..3030201) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" gene complement(3029803..3030201) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" S_feature complement(3030202..3030272) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(3030273..3030521) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" gene complement(3030273..3030521) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" promotor_-10 complement(3030544..3030563) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030555) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" promotor_-35 complement(3030579..3030582) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3030594..3030815) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" gene complement(3030594..3030815) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" downshifts complement(3030621) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" downshifts 3030809 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" promotor_-10 complement(3030833..3030852) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030839) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" promotor_-35 complement(3030865..3030874) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3030875..3031984) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" gene complement(3030875..3031984) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" promotor_-35 3031636..3031643 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3031658..3031677 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3031667..3032061 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 3031667 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" promotor_-10 complement(3032032..3032051) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(3032048) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" S_feature complement(3032050..3032490) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 3032053..3032055 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3032063 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3032065..3032070) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 3032071..3032090 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3032099..3032488 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" gene 3032099..3032488 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" CDS complement(3032529..3032765) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" gene complement(3032529..3032765) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" downshifts complement(3032535) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3032785..3032804) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032799) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" S_feature complement(3032801..3032941) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(3032818..3032827) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032942..3033472) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" gene complement(3032942..3033472) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" promotor_-10 complement(3033492..3033511) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(3033503) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" S_feature complement(3033505..3033591) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(3033523..3033531) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(3033586..3033605) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033593) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" promotor_-35 complement(3033619..3033628) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3033670..3034401) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" gene complement(3033670..3034401) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" downshifts complement(3033700) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" promotor_-10 complement(3034416..3034435) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3034427) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" promotor_-35 complement(3034450..3034457) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3034464..3034919) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" gene complement(3034464..3034919) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" promotor_-35 3034872..3034878 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3034893..3034911 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3034901..3037268 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 3034901 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" CDS complement(3034951..3038181) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" gene complement(3034951..3038181) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" CDS complement(3038178..3042665) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" gene complement(3038178..3042665) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" promotor_-35 3041940..3041946 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3041961..3041979 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3041967..3042929 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 3041967 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" CDS complement(3042726..3044081) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" gene complement(3042726..3044081) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" downshifts complement(3042747) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" CDS complement(3044096..3044335) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" gene complement(3044096..3044335) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" CDS complement(3044405..3044698) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" gene complement(3044405..3044698) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" downshifts complement(3044415) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" downshifts 3044692 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" S_feature complement(3044699..3044777) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 3044740..3044747 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3044757..3044776) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3044758 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" promotor_-10 3044762..3044779 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3044777) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" promotor_-35 complement(3044791..3044798) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3044836..3044841 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3044856..3044875 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3044868..3044974 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 3044868 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" promotor_-35 3045043..3045049 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3045063..3045082 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3045066 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3045171..3045174 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 3045183 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" promotor_-10 complement(3045186..3045205) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3045190..3045209 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(3045208) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3045219..3046487 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" gene 3045219..3046487 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" promotor_-35 complement(3045220..3045227) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3046547..3046566 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3046552 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" CDS 3046589..3047725 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" gene 3046589..3047725 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" downshifts 3047725 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" promotor_-35 3047774..3047782 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3047792 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" promotor_-10 3047794..3047812 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3047837..3048514 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" gene 3047837..3048514 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" downshifts 3048498 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" CDS complement(3048558..3048767) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" gene complement(3048558..3048767) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" downshifts complement(3048570) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" CDS complement(3048783..3055919) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" gene complement(3048783..3055919) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" CDS complement(3055939..3056877) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" gene complement(3055939..3056877) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" CDS complement(3056905..3058524) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" gene complement(3056905..3058524) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" CDS complement(3058553..3059749) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" gene complement(3058553..3059749) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" promotor_-35 3059597..3059604 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059619..3059638 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3059626 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3059775..3060560) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" gene complement(3059775..3060560) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" S_feature complement(3060561..3060670) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(3060665..3060684) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3060670) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" S_feature complement(3060672..3060753) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(3060698..3060705) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3060754..3061623) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" gene complement(3060754..3061623) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" S_feature complement(3061624..3061704) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(3061688..3061707) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061704) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" promotor_-35 complement(3061721..3061728) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3061837..3062433) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" gene complement(3061837..3062433) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" S_feature complement(3062434..3062518) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 3062469..3062476 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3062486 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" promotor_-10 3062491..3062510 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3062512..3062526) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3062518) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" promotor_-35 complement(3062534..3062538) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3062534..3063136 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" gene 3062534..3063136 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" downshifts 3063122 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" CDS complement(3063206..3064534) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" gene complement(3063206..3064534) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" downshifts complement(3063222) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" promotor_-10 complement(3064588..3064607) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3064591) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" promotor_-35 complement(3064622..3064629) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3064681..3066183) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" gene complement(3064681..3066183) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" downshifts complement(3064696) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" misc_feature 3065748..3065762 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3065764 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3066184..3066258) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 3066206..3066213 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3066224..3066243 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3066226..3066340 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 3066226 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" misc_feature complement(3066253..3066272) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3066263) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" CDS 3066341..3066817 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" gene 3066341..3066817 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" downshifts 3066766 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" CDS complement(3066848..3067504) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" gene complement(3066848..3067504) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" downshifts complement(3066876) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3067152..3067161 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3067175..3067194 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3067192 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" S_feature 3067194..3067640 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(3067518) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" promotor_-10 complement(3067520..3067531) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3067546..3067552) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3067597 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" CDS complement(3067608..3067928) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" gene complement(3067608..3067928) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" downshifts complement(3067622) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" S_feature 3067642..3067852 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 3067794..3067894 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3067854..3067963 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 3067854 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" downshifts 3067920 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3067947..3067966) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067952) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" S_feature 3067965..3068516 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(3067981..3067988) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3067982..3068125) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" gene complement(3067982..3068125) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" promotor_-10 complement(3068149..3068168) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3068170) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" promotor_-35 complement(3068184..3068187) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3068298..3069518) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" gene complement(3068298..3069518) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" downshifts complement(3068326) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" S_feature complement(3069519..3069646) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(3069646) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" S_feature complement(3069648..3069712) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(3069648..3069666) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3069682..3069687) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3069703..3069722) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069711) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" promotor_-35 complement(3069737..3069744) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3069786..3069793 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3069805..3069824 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3069805 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" CDS 3069850..3070848 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" gene 3069850..3070848 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" promotor_-10 complement(3069873..3069891) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069888) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3069908..3069913) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3070824 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" CDS complement(3070887..3071027) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" gene complement(3070887..3071027) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" downshifts complement(3070899) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" S_feature complement(3071028..3071157) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(3071138..3071157) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3071157) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" S_feature complement(3071159..3071406) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(3071171..3071177) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3071214..3071221 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3071235..3071254 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3071243 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" CDS 3071306..3072286 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" gene 3071306..3072286 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" upshifts complement(3071407) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" promotor_-10 complement(3071411..3071422) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3071436..3071442) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3072254 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" downshifts complement(3072359) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" CDS complement(3072360..3072983) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" gene complement(3072360..3072983) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" CDS complement(3073007..3073525) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" gene complement(3073007..3073525) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" misc_feature complement(3073572..3073591) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3073584) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3073586..3073694) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(3073681..3073698) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073692) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" promotor_-35 complement(3073713..3073720) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3073848) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" CDS complement(3073863..3074225) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" gene complement(3073863..3074225) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" promotor_-10 complement(3074256..3074275) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074266) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3074289..3074296) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3074304..3075158) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" gene complement(3074304..3075158) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" promotor_-10 complement(3074874..3074893) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074882) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" promotor_-35 complement(3074906..3074915) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3075180..3075199) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075194) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" promotor_-35 complement(3075214..3075217) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3075281..3076495) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" gene complement(3075281..3076495) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" promotor_-35 3075830..3075836 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3075851..3075869 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3075858 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" S_feature 3075862..3076631 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(3076532..3076551) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(3076537) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" promotor_-35 complement(3076566..3076573) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 3076588 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" CDS complement(3076632..3076868) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" gene complement(3076632..3076868) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" S_feature 3076633..3077049 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(3076650) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" promotor_-10 complement(3076833..3076834) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3076838..3076842) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3076840) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-10 complement(3076883..3076902) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3076884) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" promotor_-35 complement(3076916..3076923) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3077026..3077031 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 3077045..3077064 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 3077051 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" CDS 3077131..3078198 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" gene 3077131..3078198 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" downshifts 3078182 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" CDS complement(3078224..3078550) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" gene complement(3078224..3078550) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" downshifts complement(3078247) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3078582..3078601) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3078599) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" promotor_-35 complement(3078614..3078621) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3078634..3078638 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3078650..3078985 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" gene 3078650..3078985 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" promotor_-10 3078651..3078670 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3078656 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" downshifts complement(3078775) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" downshifts 3078963 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" CDS complement(3079027..3081000) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" gene complement(3079027..3081000) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" downshifts complement(3079039) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3081015..3081033) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081038) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" promotor_-35 complement(3081045..3081053) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3081108..3082037) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" gene complement(3081108..3082037) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" downshifts complement(3081121) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" CDS complement(3082034..3083092) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" gene complement(3082034..3083092) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" CDS complement(3083092..3084393) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" gene complement(3083092..3084393) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" promotor_-35 3084278..3084287 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084302..3084321 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3084309 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3084394..3084475) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(3084460..3084479) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3084475) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" S_feature complement(3084477..3084593) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(3084494..3084501) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3084594..3085613) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" gene complement(3084594..3085613) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" promotor_-35 3085421..3085426 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3085442..3085460 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085446 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3085636..3085654) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085643) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" promotor_-35 3085652..3085657 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3085670..3085675) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3085673..3085737 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 3085673..3085691 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085673 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" promotor_-35 3085710..3085719 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3085732..3085751 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085739 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" CDS 3085766..3086266 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" gene 3085766..3086266 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" CDS complement(3086293..3087063) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" gene complement(3086293..3087063) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" downshifts complement(3086321) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" CDS complement(3087092..3087526) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" gene complement(3087092..3087526) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" CDS complement(3087550..3087825) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" gene complement(3087550..3087825) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" promotor_-10 complement(3087845..3087864) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087870) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" S_feature complement(3087872..3088564) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(3087878..3087885) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3087888..3087894 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087909..3087920 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087917 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" CDS 3087940..3088572 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" gene 3087940..3088572 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" downshifts 3088533 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" CDS complement(3088588..3089484) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" gene complement(3088588..3089484) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" downshifts complement(3088609) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" S_feature complement(3089485..3089619) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(3089606..3089625) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(3089619) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" promotor_-35 complement(3089641..3089645) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 3089659..3089665 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089679..3089690 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089691 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" CDS 3089719..3090699 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" gene 3089719..3090699 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" upshifts complement(3089797) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3089811..3089830) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3089847..3089850) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3090691 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" CDS complement(3090727..3091491) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" gene complement(3090727..3091491) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" downshifts complement(3090743) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3091505..3091523) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091513) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" promotor_-35 complement(3091539..3091544) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3091564..3091869) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " gene complement(3091564..3091869) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" downshifts complement(3091572) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" promotor_-10 complement(3091883..3091902) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3091906) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3091916..3091924) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3091934..3093322) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" gene complement(3091934..3093322) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" CDS complement(3093342..3094163) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" gene complement(3093342..3094163) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" CDS complement(3094181..3095029) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" gene complement(3094181..3095029) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" promotor_-35 3094548..3094553 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3094569..3094587 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3094583 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3095040..3095059) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3095055) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" CDS complement(3095067..3095414) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" gene complement(3095067..3095414) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" promotor_-10 complement(3095427..3095446) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095446) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" promotor_-35 complement(3095460..3095466) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3095511..3096851) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" gene complement(3095511..3096851) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" downshifts complement(3095539) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" downshifts complement(3096595) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" promotor_-35 3096908..3096914 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096928..3096947 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3096930..3096948) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096936 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" S_feature 3096937..3097025 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(3096947) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3096964..3096969) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3097026..3098621 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" gene 3097026..3098621 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" CDS 3098766..3100115 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " gene 3098766..3100115 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" CDS 3100121..3101413 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" gene 3100121..3101413 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" CDS 3101426..3102910 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" gene 3101426..3102910 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" CDS 3102910..3103254 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" gene 3102910..3103254 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" promotor_-35 3102976..3102979 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3102997..3103016 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103009 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3103229 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" S_feature complement(3103270..3103657) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 3103617..3103626 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3103639..3103658 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3103642 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" ncRNA complement(3103678..3103809) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" CDS 3103678..3103809 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " gene 3103678..3103809 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" gene complement(3103678..3103809) /gene="auzJ" /locus_tag="BSU_ncRNA_2" S_feature 3103810..3103878 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 3103845 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" CDS complement(3104015..3104536) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" gene complement(3104015..3104536) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" CDS complement(3104527..3106764) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" gene complement(3104527..3106764) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" CDS complement(3106765..3107598) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" gene complement(3106765..3107598) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" CDS complement(3107595..3108212) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" gene complement(3107595..3108212) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" downshifts complement(3107704) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" CDS complement(3108209..3109201) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" gene complement(3108209..3109201) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" S_feature complement(3109202..3109288) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(3109266..3109285) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109288) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" promotor_-35 complement(3109299..3109304) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3109430..3110680) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" gene complement(3109430..3110680) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" CDS complement(3110697..3111935) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" gene complement(3110697..3111935) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" CDS 3112158..3112295 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" gene 3112158..3112295 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" promotor_-35 3112317..3112320 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3112335..3112354 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3112336 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" CDS 3112377..3113243 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" gene 3112377..3113243 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" downshifts 3113246 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" CDS complement(3113277..3114380) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" gene complement(3113277..3114380) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" downshifts complement(3113292) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" S_feature complement(3114381..3115314) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 3114418..3114425 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3114439..3114458 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3114449 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-35 3114500..3114506 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3114517 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" promotor_-10 3114521..3114540 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3114562..3115290 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" gene 3114562..3115290 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" CDS complement(3115315..3116169) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" gene complement(3115315..3116169) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" misc_feature complement(3115502..3115521) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3115514) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" promotor_no_box complement(3115672..3115772) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3115712) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" CDS complement(3116183..3117085) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" gene complement(3116183..3117085) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" CDS complement(3117089..3117967) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" gene complement(3117089..3117967) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" CDS complement(3118025..3119293) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" gene complement(3118025..3119293) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" promotor_no_box 3119184..3119284 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3119244 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts complement(3119364) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" CDS complement(3119374..3120360) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" gene complement(3119374..3120360) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" upshifts 3120307 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3120310..3120314 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3120403..3120422) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3120416) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" promotor_-35 complement(3120437..3120444) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3120574) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" CDS complement(3120576..3120950) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" gene complement(3120576..3120950) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" upshifts complement(3121014) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" promotor_-10 complement(3121021..3121032) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3121046..3121052) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3121053..3122171) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" gene complement(3121053..3122171) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" promotor_-10 complement(3122196..3122215) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122202) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" S_feature complement(3122204..3122814) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3122229..3122235) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3122268..3122277 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3122291..3122310 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3122295 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" promotor_-10 complement(3122308..3122323) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122312) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3122330..3122334) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3122330..3122476 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" gene 3122330..3122476 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" CDS 3122476..3122751 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" gene 3122476..3122751 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" upshifts complement(3122620) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3122636..3122650) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3122659..3122663) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3122731 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" CDS complement(3122815..3123198) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" gene complement(3122815..3123198) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" S_feature complement(3123199..3123308) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3123309..3123587) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" gene complement(3123309..3123587) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" promotor_-10 complement(3123585..3123604) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123609) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" promotor_-35 complement(3123619..3123626) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3123750..3123856) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3123793) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" CDS complement(3123857..3125254) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" gene complement(3123857..3125254) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" downshifts 3125052 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" CDS complement(3125275..3125718) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" gene complement(3125275..3125718) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" CDS complement(3125708..3126928) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" gene complement(3125708..3126928) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" CDS complement(3126928..3128241) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" gene complement(3126928..3128241) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" CDS complement(3128259..3129044) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" gene complement(3128259..3129044) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" promotor_-10 complement(3129088..3129107) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3129089) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" promotor_-35 complement(3129121..3129128) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3129145..3129164) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3129154) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" S_feature complement(3129156..3129237) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3129180..3129184) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3129201..3129448) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" gene complement(3129201..3129448) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" CDS complement(3129238..3129375) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" gene complement(3129238..3129375) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" S_feature complement(3129376..3129460) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3129444..3129463) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129460) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" S_feature complement(3129462..3129568) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3129479..3129482) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3129569..3129946) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" gene complement(3129569..3129946) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" promotor_-10 complement(3129963..3129974) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3129969) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" promotor_-35 complement(3129988..3129994) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3130031..3130855) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" gene complement(3130031..3130855) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" downshifts complement(3130039) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3130188) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" promotor_-35 3130215..3130220 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130236..3130254 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130238 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3130869..3131537) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" gene complement(3130869..3131537) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" CDS complement(3131530..3132555) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" gene complement(3131530..3132555) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" S_feature complement(3132556..3132660) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3132661..3132767) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene complement(3132661..3132767) /gene="mswH" /locus_tag="BSU_misc_RNA_53" downshifts 3132730 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" promotor_-10 complement(3132794..3132813) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132806) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" S_feature complement(3132808..3132881) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3132829..3132836) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3132882..3133226) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" gene complement(3132882..3133226) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" S_feature complement(3133227..3133332) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3133333..3133653) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" gene complement(3133333..3133653) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" CDS complement(3133655..3134095) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" gene complement(3133655..3134095) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" CDS complement(3134095..3134331) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" gene complement(3134095..3134331) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" downshifts complement(3134107) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" upshifts complement(3134346) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" promotor_-10 complement(3134351..3134362) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3134377..3134383) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3134387..3134770) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" gene complement(3134387..3134770) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" promotor_-10 complement(3134797..3134816) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3134808) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" promotor_-35 complement(3134829..3134836) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3134837..3135193) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" gene complement(3134837..3135193) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" promotor_-10 complement(3135216..3135235) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3135226) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" promotor_-35 complement(3135249..3135254) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3135304..3137088) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" gene complement(3135304..3137088) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" downshifts complement(3135314) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" CDS complement(3137103..3138278) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " gene complement(3137103..3138278) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" CDS complement(3138289..3140658) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" gene complement(3138289..3140658) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" promotor_-35 3140077..3140082 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140097..3140115 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140100 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3140726..3140745) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3140729) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" S_feature complement(3140737..3141003) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3140759..3140766) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3140784..3140790 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140805..3140816 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140827 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" CDS 3140833..3140979 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" gene 3140833..3140979 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" S_feature 3140980..3142006 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3141004..3141912) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" gene complement(3141004..3141912) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" S_feature complement(3141913..3142435) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3142007..3142252 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" gene 3142007..3142252 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" CDS 3142265..3142597 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" gene 3142265..3142597 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" promotor_-10 complement(3142418..3142437) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142435) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" promotor_-35 complement(3142451..3142460) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3142586 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" promotor_-35 3142658..3142665 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3142679..3142698 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3142690 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" CDS 3142756..3143223 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" gene 3142756..3143223 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" CDS 3143220..3144845 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" gene 3143220..3144845 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" downshifts 3144830 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" CDS complement(3144881..3145264) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" gene complement(3144881..3145264) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" CDS complement(3145283..3145672) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" gene complement(3145283..3145672) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" CDS complement(3145694..3146023) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" gene complement(3145694..3146023) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" promotor_-10 complement(3146058..3146077) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3146065..3146072 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3146072) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3146087..3146106 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3146091..3146098) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3146097 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" CDS 3146157..3147044 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" gene 3146157..3147044 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" CDS complement(3147064..3147351) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" gene complement(3147064..3147351) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" downshifts complement(3147076) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" CDS complement(3147376..3148203) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " gene complement(3147376..3148203) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" downshifts complement(3147392) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" S_feature complement(3148204..3148341) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3148326..3148345) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3148341) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" promotor_-35 complement(3148361..3148364) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3148421..3148858) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" gene complement(3148421..3148858) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" promotor_-10 complement(3148882..3148900) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3148888) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" promotor_-35 complement(3148916..3148921) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3148968..3150476) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" gene complement(3148968..3150476) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo downshifts complement(3148989) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" CDS complement(3150467..3150763) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" gene complement(3150467..3150763) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo promotor_-10 complement(3150786..3150805) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150802) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" promotor_-35 complement(3150820..3150823) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3150840..3150845 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150857..3150876 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150857 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" CDS 3150897..3151739 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" gene 3150897..3151739 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" promotor_-35 3151269..3151275 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3151290..3151301 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3151298 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" promotor_-35 3151766..3151773 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3151782 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" promotor_-10 3151785..3151804 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3151829..3152290 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" gene 3151829..3152290 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" downshifts 3152266 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" CDS complement(3152334..3153710) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" gene complement(3152334..3153710) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" downshifts complement(3152342) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" S_feature complement(3153711..3153882) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3153863..3153882) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153882) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" promotor_-35 complement(3153893..3153900) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3153943..3153962) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3153953..3153972 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3153955 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" upshifts complement(3153961) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" S_feature complement(3153963..3155026) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3153977..3153984) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3153988..3154665 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" gene 3153988..3154665 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" CDS 3154662..3156017 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" gene 3154662..3156017 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" S_feature complement(3155116..3156044) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3155985 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" CDS complement(3156045..3156209) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" gene complement(3156045..3156209) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" promotor_-35 3156233..3156240 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3156254..3156273 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3156258..3156277) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3156264..3156376 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3156264 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" upshifts complement(3156271) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3156273..3156551) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3156291..3156298) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3156377..3157252 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" gene 3156377..3157252 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" promotor_-10 complement(3156541..3156560) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156551) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3156553..3157094) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3156574..3156581) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3157086..3157104) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157094) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" S_feature complement(3157096..3157225) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3157117..3157124) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3157227 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" downshifts complement(3157270) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3157288..3158676) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" gene complement(3157288..3158676) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" upshifts complement(3158700) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 complement(3158705..3158723) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3158734..3158742) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3158743..3158928) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" gene complement(3158743..3158928) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" downshifts 3158932 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" promotor_-10 complement(3158972..3158991) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3158981..3158987 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3158986) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" promotor_-10 3159001..3159012 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3159004 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" promotor_-35 complement(3159007..3159010) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3159046..3160494 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" gene 3159046..3160494 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" S_feature complement(3160042..3162685) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3160463..3161560 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" gene 3160463..3161560 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" CDS 3161557..3162678 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" gene 3161557..3162678 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" CDS complement(3162686..3163321) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" gene complement(3162686..3163321) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" CDS complement(3163299..3164381) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" gene complement(3163299..3164381) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" CDS complement(3164378..3165103) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" gene complement(3164378..3165103) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" CDS complement(3165137..3166009) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" gene complement(3165137..3166009) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" promotor_-10 complement(3166028..3166047) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166048) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" promotor_-35 complement(3166062..3166065) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3166110..3166787) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" gene complement(3166110..3166787) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" downshifts complement(3166126) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" CDS complement(3166814..3167194) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" gene complement(3166814..3167194) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" promotor_-10 complement(3167217..3167236) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3167237) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" promotor_-35 complement(3167251..3167254) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3167356..3168624) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" gene complement(3167356..3168624) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" downshifts complement(3167369) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3168658..3168677) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168669) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" promotor_-35 complement(3168692..3168699) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3168795) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" CDS complement(3168801..3169382) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" gene complement(3168801..3169382) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" CDS complement(3169405..3170733) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" gene complement(3169405..3170733) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" CDS complement(3170733..3171794) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" gene complement(3170733..3171794) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" CDS complement(3171757..3172701) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" gene complement(3171757..3172701) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" S_feature complement(3172702..3172971) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3172810..3172940) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" gene complement(3172810..3172940) /gene="srbL" /locus_tag="BSU_misc_RNA_85" promotor_-10 complement(3172948..3172967) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172971) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" S_feature complement(3172973..3173900) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3172983..3172990) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3173033..3173040 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3173055..3173074 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3173059 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" CDS 3173099..3173890 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" gene 3173099..3173890 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" downshifts 3173761 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" downshifts 3173871 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" CDS complement(3173928..3174806) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" gene complement(3173928..3174806) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" downshifts complement(3173945) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3174830..3174848) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3174849) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" promotor_-35 complement(3174862..3174868) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3174878..3176620) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" gene complement(3174878..3176620) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" CDS complement(3176617..3177330) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" gene complement(3176617..3177330) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" misc_feature complement(3177361..3177380) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3177379) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" CDS complement(3177483..3177722) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" gene complement(3177483..3177722) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" downshifts complement(3177490) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3177718..3177736) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3177726..3178256) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" gene complement(3177726..3178256) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" upshifts complement(3177727) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3177751..3177757) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3178259..3178278) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178266) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" CDS 3178271..3178609 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" gene 3178271..3178609 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" promotor_-35 complement(3178293..3178300) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3178309..3178328) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178321) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" promotor_-35 complement(3178343..3178349) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3178355..3178455 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3178415 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" promotor_no_box 3178583..3178683 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3178643..3178729 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3178643 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" CDS 3178730..3179887 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" gene 3178730..3179887 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" downshifts 3179873 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" CDS 3179948..3180358 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" gene 3179948..3180358 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" downshifts 3180357 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" CDS complement(3180392..3181621) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" gene complement(3180392..3181621) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" downshifts complement(3180409) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" CDS complement(3181614..3182303) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" gene complement(3181614..3182303) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" CDS complement(3182287..3183480) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" gene complement(3182287..3183480) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" promotor_-10 complement(3183524..3183543) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183537) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" promotor_-35 complement(3183558..3183565) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3183651..3184460) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" gene complement(3183651..3184460) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" downshifts complement(3183668) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3183807..3183816 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3183829..3183848 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3183833 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3184476..3185486) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" gene complement(3184476..3185486) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" CDS complement(3185486..3186640) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" gene complement(3185486..3186640) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" promotor_-10 complement(3186573..3186592) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186590) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" promotor_-35 complement(3186604..3186611) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3186652..3186659 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186674..3186693 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186683 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" CDS 3186738..3187685 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" gene 3186738..3187685 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" downshifts 3187661 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" downshifts 3187705 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" downshifts 3187859 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" CDS complement(3187920..3189329) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" gene complement(3187920..3189329) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" downshifts complement(3187935) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" promotor_-35 3188747..3188751 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188769..3188785 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188776 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" S_feature 3188783..3189750 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3189431) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" misc_RNA complement(3189433..3189612) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" gene complement(3189433..3189612) /gene="kswB" /locus_tag="BSU_misc_RNA_54" promotor_-10 complement(3189642..3189659) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189653) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" promotor_-35 complement(3189674..3189681) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3189707 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" CDS complement(3189729..3189869) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" gene complement(3189729..3189869) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" downshifts complement(3189739) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" upshifts complement(3189897) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" S_feature complement(3189899..3190487) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3189902..3189913) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3189927..3189933) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3189959..3189966 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3189980 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" promotor_-10 3189982..3190001 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3190036..3190518 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" gene 3190036..3190518 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" promotor_-35 3190532..3190539 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3190553..3190572 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3190565 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" CDS 3190618..3192471 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" gene 3190618..3192471 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" downshifts 3192457 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" CDS complement(3192499..3193425) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" gene complement(3192499..3193425) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" downshifts complement(3192511) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3193437..3193456) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193458) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" promotor_-35 complement(3193472..3193475) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3193494..3193513 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3193503 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" CDS 3193536..3194318 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" gene 3193536..3194318 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" CDS 3194290..3194982 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" gene 3194290..3194982 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" downshifts 3194974 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" CDS complement(3195013..3195843) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" gene complement(3195013..3195843) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" downshifts complement(3195019) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" promotor_-35 3195706..3195710 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3195726..3195730 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3195735 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3195845 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" promotor_-10 complement(3195873..3195892) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195891) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" promotor_-35 complement(3195907..3195914) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3195999..3196005 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3196019 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" promotor_-10 3196020..3196038 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3196066..3196551 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" gene 3196066..3196551 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" downshifts 3196550 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" CDS complement(3196595..3198607) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" gene complement(3196595..3198607) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" downshifts complement(3196603) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3198273..3198277) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3198275) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3198608..3198759) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3198736..3198754) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3198759) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" CDS complement(3198862..3200577) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" gene complement(3198862..3200577) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" downshifts complement(3198869) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" CDS complement(3200603..3202420) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" gene complement(3200603..3202420) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" promotor_-10 complement(3202462..3202481) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3202471..3202478 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3202481) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" upshifts 3202484 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3202491..3202510 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3202494..3202501) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3202591..3204915) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" gene complement(3202591..3204915) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" downshifts complement(3202609) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" promotor_-35 3204935..3204942 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204957..3204976 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3204958..3204973) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3204961 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3204963) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-10 complement(3205008..3205027) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205017) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3205043..3205049) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3205053..3205072) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205073) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" promotor_-35 complement(3205086..3205094) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3205100) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" CDS complement(3205113..3205721) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" gene complement(3205113..3205721) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" promotor_-10 complement(3205760..3205779) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205777) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" promotor_-35 complement(3205795..3205799) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3205908..3206324) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" gene complement(3205908..3206324) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" downshifts complement(3205918) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" CDS complement(3206329..3206997) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" gene complement(3206329..3206997) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" promotor_-10 complement(3207049..3207068) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3207064) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" downshifts complement(3207075) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3207082..3207087) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3207117..3209225) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" gene complement(3207117..3209225) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" S_feature complement(3209217..3209318) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3209312..3209331) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209318) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" promotor_-35 complement(3209347..3209354) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3209385..3211793) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" gene complement(3209385..3211793) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" downshifts complement(3209407) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" downshifts complement(3209473) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3211794..3211876) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3211877..3212086) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" gene complement(3211877..3212086) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" promotor_-10 complement(3212110..3212129) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3212131) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" promotor_-35 complement(3212142..3212148) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3212160..3212465) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " gene complement(3212160..3212465) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" misc_feature 3212429..3212448 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3212440 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3212479..3212498) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3212505) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" promotor_-35 complement(3212512..3212518) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3212557..3212563 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3212578..3212596 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3212586 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" CDS 3212593..3213669 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" gene 3212593..3213669 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" downshifts 3213656 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" CDS complement(3213706..3214341) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" gene complement(3213706..3214341) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" downshifts complement(3213719) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" S_feature complement(3214342..3214439) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3214419..3214438) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3214439) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" promotor_-35 complement(3214452..3214458) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3214501..3216396) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" gene complement(3214501..3216396) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" promotor_-10 complement(3216447..3216458) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216447) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3216473..3216479) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3216546) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" CDS complement(3216559..3216960) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" gene complement(3216559..3216960) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" CDS complement(3216957..3217316) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" gene complement(3216957..3217316) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" CDS complement(3217313..3217885) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" gene complement(3217313..3217885) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" promotor_-10 complement(3217923..3217942) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217928) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" promotor_-35 complement(3217956..3217963) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3217996..3218790) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" gene complement(3217996..3218790) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" promotor_-10 complement(3218811..3218829) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218823) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" promotor_-35 complement(3218844..3218850) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3218856..3218875) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3218867) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" S_feature complement(3218869..3218934) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3218889..3218896) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3218976..3219335) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" gene complement(3218976..3219335) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" downshifts complement(3218979) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3219319..3219327) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219329) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" promotor_-35 complement(3219342..3219347) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3219387..3219406) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219395) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" S_feature complement(3219397..3219461) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3219419..3219423) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3219461) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" promotor_-10 complement(3219462..3219481) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3219496..3219503) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3219512..3219982) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" gene complement(3219512..3219982) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" promotor_no_box 3219809..3219909 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3219869 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3219979 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3220027..3220046) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3220033) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" S_feature complement(3220035..3220126) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3220062..3220065) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3220127..3222466) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" gene complement(3220127..3222466) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" promotor_-35 3221227..3221230 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3221246..3221249 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3221255 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3222485..3223225) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" gene complement(3222485..3223225) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" promotor_-10 complement(3222881..3222899) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3222893) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" promotor_-35 complement(3222914..3222920) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3223253..3223271) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3223267) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" downshifts complement(3223355) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" CDS complement(3223357..3223587) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" gene complement(3223357..3223587) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" promotor_-10 complement(3223617..3223636) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3223638) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" promotor_-35 complement(3223651..3223654) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3223676..3223682 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3223696..3223707 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3223697 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" CDS 3223736..3224506 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" gene 3223736..3224506 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" promotor_-35 3223758..3223766 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3223777..3223795 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3223807 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3224546..3224779) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" gene complement(3224546..3224779) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" promotor_-35 3224870..3224877 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3224885 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" promotor_-10 3224889..3224908 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3224931..3225338 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" gene 3224931..3225338 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" CDS 3225368..3225787 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" gene 3225368..3225787 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" promotor_-35 3225825..3225832 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225846..3225865 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225853 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" CDS 3225879..3226205 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" gene 3225879..3226205 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" S_feature 3226206..3226290 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3226261..3226268 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226281..3226299 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226292 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" CDS 3226330..3228030 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" gene 3226330..3228030 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" S_feature complement(3227046..3228039) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3228008 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" CDS complement(3228070..3228750) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" gene complement(3228070..3228750) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" downshifts complement(3228084) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" promotor_-35 3228444..3228450 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228465..3228483 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3228470..3231221 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3228470 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" CDS complement(3228767..3229687) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" gene complement(3228767..3229687) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" CDS complement(3229699..3230352) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " gene complement(3229699..3230352) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" CDS complement(3230369..3231514) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" gene complement(3230369..3231514) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" S_feature complement(3231515..3231582) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3231582) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" promotor_-10 complement(3231583..3231602) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3231613..3231617 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3231617..3231620) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3231633..3231651 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3231638 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" promotor_-35 3231733..3231737 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3231753..3231772 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3231756 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" CDS 3231798..3232331 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" gene 3231798..3232331 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" S_feature complement(3231998..3232517) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3232320 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" promotor_-35 3232454..3232461 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3232474..3232552 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3232474 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" promotor_-10 3232476..3232495 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3232502..3232516) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232517) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3232526) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3232553..3233029 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" gene 3232553..3233029 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" promotor_-10 complement(3232578..3232597) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232588) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" promotor_-35 complement(3232609..3232616) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3233026..3233997 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" gene 3233026..3233997 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" promotor_no_box 3233834..3233934 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3233894 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" promotor_-10 complement(3233906..3233923) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233927) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" S_feature complement(3233929..3234331) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3233940..3233942) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3233958) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" CDS 3234040..3234651 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" gene 3234040..3234651 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" S_feature complement(3234333..3234419) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3234376) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" S_feature complement(3234421..3234606) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3234464) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" downshifts 3234631 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" downshifts complement(3234651) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" S_feature 3234676..3235814 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3234698..3235321) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" gene complement(3234698..3235321) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" downshifts complement(3234706) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" CDS complement(3235318..3235590) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" gene complement(3235318..3235590) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" promotor_-10 complement(3235646..3235665) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235655) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" S_feature complement(3235657..3235805) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3235677..3235683) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3235810..3236499) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" gene complement(3235810..3236499) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" downshifts complement(3235850) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" promotor_-35 3236442..3236450 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3236464..3236483 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3236478 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3236517..3237428) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" gene complement(3236517..3237428) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" CDS complement(3237448..3238101) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " gene complement(3237448..3238101) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" CDS complement(3238124..3239266) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" gene complement(3238124..3239266) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" promotor_-10 complement(3239310..3239329) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3239325) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" promotor_-35 complement(3239344..3239347) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3239463..3239470 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3239483..3239502 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3239494 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" CDS 3239530..3240087 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" gene 3239530..3240087 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" S_feature 3240088..3240852 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3240105..3240740) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" gene complement(3240105..3240740) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" downshifts complement(3240118) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3240781..3240799) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240787) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" promotor_-35 complement(3240815..3240821) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3240826..3240833 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3240845..3240864 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3240854 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" CDS 3240890..3241504 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" gene 3240890..3241504 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" downshifts 3241490 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" promotor_-35 3241558..3241561 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3241576..3241595 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3241584 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" CDS 3241636..3242334 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" gene 3241636..3242334 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" downshifts 3242307 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" CDS complement(3242370..3244187) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" gene complement(3242370..3244187) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" downshifts complement(3242389) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" downshifts complement(3242560) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" misc_feature complement(3244229..3244248) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3244233..3244252 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244238 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" upshifts complement(3244242) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" CDS 3244307..3244774 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" gene 3244307..3244774 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" downshifts 3244771 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" CDS complement(3244819..3246111) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" gene complement(3244819..3246111) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" downshifts complement(3244829) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" CDS complement(3246141..3247676) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" gene complement(3246141..3247676) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" CDS complement(3247669..3248430) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" gene complement(3247669..3248430) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" CDS complement(3248461..3249645) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" gene complement(3248461..3249645) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" S_feature complement(3249646..3249886) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3249886) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3249888..3249961) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3249900..3249919) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3249935..3249939) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3249962..3250969) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" gene complement(3249962..3250969) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" promotor_-35 3250888..3250891 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3250908..3250910 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3250910 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3251016..3252038) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" gene complement(3251016..3252038) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" upshifts complement(3251032) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" promotor_-10 complement(3251040) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3251060..3251061) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3252039..3252150) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3252076 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" promotor_-10 complement(3252131..3252150) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3252150) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" S_feature complement(3252152..3252262) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3252164..3252171) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3252245..3252264) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3252260) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" promotor_-35 complement(3252277..3252286) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3252336..3253730) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" gene complement(3252336..3253730) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" downshifts complement(3252350) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3253829..3253848) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253843) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" promotor_-35 complement(3253863..3253870) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3253870..3253877 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3253891..3253910 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3253897 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" CDS 3253934..3255022 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" gene 3253934..3255022 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" downshifts 3255002 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" CDS complement(3255071..3256081) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" gene complement(3255071..3256081) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" downshifts complement(3255078) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" S_feature complement(3256082..3256159) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3256149..3256168) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256159) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" promotor_-35 complement(3256182..3256189) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3256238..3257116) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" gene complement(3256238..3257116) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" promotor_-35 3256774..3256780 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256795..3256806 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3256806 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3257150..3257157 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3257163..3257182) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3257168) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" promotor_-10 3257171..3257190 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3257173 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" promotor_-35 complement(3257196..3257200) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3257216..3258133 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" gene 3257216..3258133 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" downshifts 3258122 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" CDS complement(3258174..3259517) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" gene complement(3258174..3259517) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" misc_RNA complement(3259586..3259821) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" gene complement(3259586..3259821) /gene="tboX" /locus_tag="BSU_misc_RNA_56" downshifts complement(3259720) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3259822..3259918) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3259919..3260953) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" gene complement(3259919..3260953) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" promotor_-10 complement(3260975..3260993) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3260981) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" promotor_-35 complement(3261006..3261013) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261061..3261783) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" gene complement(3261061..3261783) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" downshifts complement(3261077) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" CDS complement(3261783..3263222) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" gene complement(3261783..3263222) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" promotor_-35 3262770..3262773 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3262790 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3262791..3262795 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3262944 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" upshifts 3263098 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3263099..3263100 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3263249..3263965) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" gene complement(3263249..3263965) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" promotor_-35 3263869..3263876 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3263890..3263892 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3263890 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3263963 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" S_feature complement(3263966..3264032) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3264029..3264048) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3264032) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" promotor_-35 complement(3264063..3264070) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3264140..3264742) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" gene complement(3264140..3264742) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" CDS complement(3264759..3265874) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" gene complement(3264759..3265874) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" CDS complement(3265878..3266615) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" gene complement(3265878..3266615) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" promotor_-10 complement(3265904..3265923) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3265918) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" promotor_-35 complement(3265935..3265942) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3266616..3267521) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" gene complement(3266616..3267521) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" promotor_-10 complement(3267541..3267559) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267552) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3267575..3267578) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3267730..3267737 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3267748..3267767 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3267755 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" CDS 3267805..3268614 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" gene 3267805..3268614 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" CDS 3268650..3269861 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" gene 3268650..3269861 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" downshifts 3269848 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" CDS complement(3269915..3271204) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" gene complement(3269915..3271204) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" CDS complement(3271284..3273347) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" gene complement(3271284..3273347) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" CDS complement(3273366..3274217) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" gene complement(3273366..3274217) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" CDS complement(3274221..3275477) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" gene complement(3274221..3275477) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" CDS complement(3275517..3276782) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" gene complement(3275517..3276782) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" promotor_-10 complement(3276814..3276833) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276836) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" promotor_-35 complement(3276848..3276855) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3276923..3277915) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" gene complement(3276923..3277915) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" downshifts complement(3276957) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" S_feature complement(3278045..3278094) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3278068) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" CDS complement(3278095..3278754) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" gene complement(3278095..3278754) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" S_feature complement(3278755..3278860) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3278852..3278871) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278861) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" promotor_-35 complement(3278886..3278889) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3278913..3278920 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3278935..3278954 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3278935 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" S_feature 3278938..3279043 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3278944..3278961) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278948) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3278969..3278975) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3279044..3280735 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" gene 3279044..3280735 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" downshifts 3280720 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" CDS complement(3280762..3282072) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" gene complement(3280762..3282072) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" S_feature 3280765..3281835 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3280774) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" misc_feature 3281892..3281911 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3281892..3282150 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3281892 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" promotor_-10 complement(3282086..3282105) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3282101) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" promotor_-35 complement(3282120..3282123) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3282151..3282369 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" gene 3282151..3282369 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" downshifts 3282348 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" CDS complement(3282379..3283347) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" gene complement(3282379..3283347) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" CDS complement(3283326..3284492) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" gene complement(3283326..3284492) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" CDS complement(3284497..3285147) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" gene complement(3284497..3285147) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" CDS complement(3285144..3285752) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" gene complement(3285144..3285752) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" CDS complement(3285749..3287266) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" gene complement(3285749..3287266) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" CDS complement(3287263..3288297) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" gene complement(3287263..3288297) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" CDS complement(3288294..3289370) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" gene complement(3288294..3289370) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" CDS complement(3289375..3290409) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" gene complement(3289375..3290409) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" CDS complement(3290434..3291537) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" gene complement(3290434..3291537) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" CDS complement(3291534..3292688) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" gene complement(3291534..3292688) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" CDS complement(3292681..3293517) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" gene complement(3292681..3293517) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" CDS complement(3293514..3294659) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" gene complement(3293514..3294659) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" CDS complement(3294671..3296467) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" gene complement(3294671..3296467) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" S_feature complement(3296468..3296527) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3296501..3296519) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296527) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" promotor_-35 complement(3296533..3296539) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3296726..3297409) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" gene complement(3296726..3297409) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" CDS complement(3297415..3298119) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" gene complement(3297415..3298119) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" promotor_-35 3298084 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3298101 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" promotor_-10 3298104..3298122 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3298120..3298177) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3298173..3298192) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298178) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" promotor_-35 complement(3298206..3298213) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3298295..3298300 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3298315..3298334 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3298321 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" CDS 3298365..3298823 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" gene 3298365..3298823 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" promotor_-35 3298845..3298848 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3298854 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" promotor_-10 3298865..3298883 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3298899..3300368 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" gene 3298899..3300368 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" downshifts 3300345 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" CDS 3300371..3300562 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" gene 3300371..3300562 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" downshifts 3300541 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" CDS complement(3300589..3301074) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" gene complement(3300589..3301074) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" CDS complement(3301097..3301408) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" gene complement(3301097..3301408) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo CDS complement(3301460..3301552) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" gene complement(3301460..3301552) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo promotor_-10 complement(3301592..3301611) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3301609) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3301625..3301632) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3301683..3302366) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" gene complement(3301683..3302366) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" downshifts complement(3301701) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" CDS complement(3302382..3303737) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" gene complement(3302382..3303737) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" promotor_-10 complement(3303749..3303764) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303765) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" promotor_-35 complement(3303776..3303785) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3304039..3304046 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304060..3304079 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3304063 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" S_feature 3304085..3304275 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3304276..3305697 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" gene 3304276..3305697 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" downshifts 3305691 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" CDS 3305771..3307321 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" gene 3305771..3307321 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" promotor_-35 3307365..3307371 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3307385..3307396 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3307385 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" CDS 3307429..3308991 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" gene 3307429..3308991 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" downshifts 3308969 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" CDS 3308981..3309670 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" gene 3308981..3309670 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" promotor_-35 3309020..3309027 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309041..3309060 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309050 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" downshifts 3309651 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" downshifts complement(3309749) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" CDS 3309752..3310087 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" gene 3309752..3310087 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" CDS 3310087..3310407 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" gene 3310087..3310407 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" S_feature 3310408..3310598 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3310443..3310955) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" gene complement(3310443..3310955) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" downshifts 3310575 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3310991..3311002) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310997) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3311017..3311023) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3311070..3311206) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3311113) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" CDS complement(3311207..3312550) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" gene complement(3311207..3312550) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" promotor_-10 complement(3312579..3312598) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312587) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" promotor_-35 complement(3312611..3312620) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3312612..3312617 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3312633..3312651 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3312636 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3312845..3312854 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3312863 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" promotor_-10 3312868..3312887 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3312906..3313868 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" gene 3312906..3313868 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" S_feature 3313869..3314122 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3314149) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" tRNA complement(3314153..3314228) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3314153..3314228) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" promotor_-10 complement(3314255..3314274) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314276) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" promotor_-35 complement(3314290..3314293) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3314359..3314365 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3314375..3314450 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3314375 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" promotor_-10 3314380..3314399 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3314427..3314434 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314448..3314467 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314452 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" CDS 3314498..3315091 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" gene 3314498..3315091 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" downshifts 3315080 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" S_feature 3315125..3315523 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3315137..3315817) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" gene complement(3315137..3315817) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" downshifts complement(3315161) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" CDS complement(3315814..3317499) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" gene complement(3315814..3317499) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" CDS complement(3317492..3319765) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" gene complement(3317492..3319765) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" CDS complement(3319743..3320627) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" gene complement(3319743..3320627) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" CDS complement(3320633..3321469) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" gene complement(3320633..3321469) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" CDS complement(3321470..3322777) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" gene complement(3321470..3322777) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" promotor_-35 3321835..3321844 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3321857..3321876 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3321861 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3322817..3324070) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" gene complement(3322817..3324070) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" S_feature complement(3324071..3324165) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3324166..3325935) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" gene complement(3324166..3325935) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" promotor_-35 3325856..3325861 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325877..3325895 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3325887 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3325973..3325992) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3325986) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" promotor_-35 complement(3326005..3326012) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3326048..3326998) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" gene complement(3326048..3326998) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" promotor_-10 complement(3327013..3327031) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327026) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3327043..3327051) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3327132) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" CDS complement(3327204..3327779) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" gene complement(3327204..3327779) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" downshifts complement(3327216) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" promotor_-10 complement(3327822..3327841) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3327828..3327835 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3327838) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" upshifts 3327845 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" promotor_-10 3327848..3327867 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3327856..3327863) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3327896..3328216 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" gene 3327896..3328216 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" downshifts 3328197 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" downshifts complement(3328243) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" CDS complement(3328243..3329835) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" gene complement(3328243..3329835) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" CDS complement(3329854..3330447) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" gene complement(3329854..3330447) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" promotor_-10 complement(3330489..3330508) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330502) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" promotor_-35 complement(3330523..3330527) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3330573..3330578 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330594..3330612 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330595 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" promotor_-35 3330768..3330775 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330789..3330808 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330793 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" CDS 3330830..3331807 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" gene 3330830..3331807 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" downshifts 3331779 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" CDS complement(3331845..3333785) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" gene complement(3331845..3333785) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" downshifts complement(3331869) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" CDS complement(3333760..3334539) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" gene complement(3333760..3334539) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" S_feature complement(3334540..3334621) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3334622..3335692) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" gene complement(3334622..3335692) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" CDS complement(3335686..3336399) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" gene complement(3335686..3336399) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" promotor_-10 complement(3336445..3336464) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336457) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3336459..3336720) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3336477..3336480) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3336480..3336487 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3336498..3336517 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3336503 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" CDS 3336546..3336755 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" gene 3336546..3336755 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" downshifts 3336733 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" downshifts complement(3336765) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" CDS complement(3336791..3337555) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" gene complement(3336791..3337555) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" downshifts complement(3336813) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" CDS complement(3337556..3337813) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" gene complement(3337556..3337813) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" CDS complement(3337837..3338787) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" gene complement(3337837..3338787) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" CDS complement(3338810..3339763) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" gene complement(3338810..3339763) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" CDS complement(3339765..3340652) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" gene complement(3339765..3340652) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" CDS complement(3340677..3341153) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" gene complement(3340677..3341153) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" promotor_-10 complement(3341173..3341192) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3341187) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" promotor_-35 complement(3341208..3341212) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3341231..3341250) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3341244) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" promotor_-35 complement(3341265..3341268) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3341320..3341470) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3341363) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" CDS complement(3341471..3342421) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" gene complement(3341471..3342421) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" S_feature complement(3342422..3342509) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3342498..3342517) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342509) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" S_feature complement(3342511..3342602) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3342532..3342535) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3342550..3342556 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3342570..3342588 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3342584 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" S_feature 3342585..3345971 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3342627..3344048) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" gene complement(3342627..3344048) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" downshifts complement(3342647) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" downshifts complement(3342771) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" misc_feature 3343675..3343679 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3343685 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3343964..3343968 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3343971 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3344049..3344246) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3344169 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" promotor_-10 complement(3344234..3344253) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3344246) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" promotor_-35 complement(3344265..3344272) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3344429..3345883) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" gene complement(3344429..3345883) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" downshifts complement(3344449) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" S_feature complement(3345884..3346008) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3345929 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" CDS complement(3346009..3347778) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" gene complement(3346009..3347778) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" S_feature complement(3347779..3347853) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3347842..3347861) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3347853) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" CDS complement(3347943..3348302) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" gene complement(3347943..3348302) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" downshifts complement(3347963) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" CDS complement(3348317..3350227) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" gene complement(3348317..3350227) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" CDS complement(3350229..3350954) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" gene complement(3350229..3350954) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" S_feature complement(3350955..3351043) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3351043..3351062) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351043) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" S_feature complement(3351045..3351174) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3351078..3351081) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3351200..3351829) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" gene complement(3351200..3351829) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" downshifts complement(3351219) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" CDS complement(3351826..3352584) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" gene complement(3351826..3352584) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" CDS complement(3352581..3353318) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" gene complement(3352581..3353318) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" CDS complement(3353315..3353953) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" gene complement(3353315..3353953) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" promotor_no_box 3353811..3353911 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3353871 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3353954..3354538) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" gene complement(3353954..3354538) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" CDS complement(3354535..3355818) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" gene complement(3354535..3355818) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" CDS complement(3355815..3356456) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" gene complement(3355815..3356456) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" CDS complement(3356449..3357624) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " gene complement(3356449..3357624) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" S_feature complement(3357625..3357702) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3357668..3357674 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357686..3357705 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3357686..3357705) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357699 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3357702) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" promotor_-35 complement(3357718..3357725) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3357834..3357853 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3357841 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" CDS 3357875..3358627 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" gene 3357875..3358627 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" S_feature 3358628..3358866 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3358649..3358660) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358655) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3358675..3358681) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3358867..3359532 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" gene 3358867..3359532 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" downshifts 3359503 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" CDS complement(3359552..3360070) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" gene complement(3359552..3360070) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" downshifts complement(3359586) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" CDS complement(3360074..3360724) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" gene complement(3360074..3360724) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" CDS complement(3360721..3361659) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" gene complement(3360721..3361659) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" CDS complement(3361683..3362492) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" gene complement(3361683..3362492) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" CDS complement(3362506..3363438) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" gene complement(3362506..3363438) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" promotor_-10 complement(3363480..3363499) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363486) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" promotor_-35 complement(3363515..3363520) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3363555..3363562 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3363574 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3363577..3363594 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3363620..3364810 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" gene 3363620..3364810 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" promotor_-35 3364608..3364614 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3364629 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" promotor_-10 3364630..3364648 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3364807..3365535 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" gene 3364807..3365535 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" CDS 3365553..3366284 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" gene 3365553..3366284 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" CDS complement(3366304..3370173) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" gene complement(3366304..3370173) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" downshifts complement(3366426) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" promotor_-10 complement(3370193..3370204) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370200) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" promotor_-35 complement(3370219..3370225) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3370263..3370269 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370283..3370302 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3370288 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" CDS 3370338..3370811 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" gene 3370338..3370811 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" S_feature 3370812..3370919 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3370852..3372069) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" gene complement(3370852..3372069) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" downshifts complement(3370865) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" promotor_-35 3370891..3370896 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370911..3370922 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3370921..3371206 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3370921 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" downshifts 3371163 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" CDS complement(3372085..3372831) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" gene complement(3372085..3372831) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" S_feature complement(3372832..3373018) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3373004..3373023) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373018) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" promotor_-35 complement(3373037..3373044) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3373152..3373159 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3373174..3373193 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3373186 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" S_feature 3373187..3373256 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3373257..3373766 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" gene 3373257..3373766 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" S_feature complement(3373662..3375000) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3373703) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" CDS 3373787..3374998 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" gene 3373787..3374998 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" downshifts 3374996 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" CDS complement(3375026..3375385) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" gene complement(3375026..3375385) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" S_feature 3375041..3375757 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3375045) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" CDS complement(3375387..3375584) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" gene complement(3375387..3375584) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" CDS complement(3375589..3376686) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" gene complement(3375589..3376686) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" CDS complement(3376711..3377037) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" gene complement(3376711..3377037) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" promotor_-10 complement(3377090..3377105) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377105) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" S_feature complement(3377107..3377597) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3377117..3377126) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3377185..3377188 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3377203..3377222 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3377213 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" CDS 3377255..3377485 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" gene 3377255..3377485 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" promotor_-10 complement(3377588..3377607) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3377598) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" promotor_-35 complement(3377623..3377627) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3377684..3378166) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" gene complement(3377684..3378166) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo downshifts 3377692 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" downshifts complement(3377707) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" upshifts complement(3377839) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3377847..3377850) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3377927..3377931) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377927) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3377947..3377950) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3378167..3378300) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3378328..3381201) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" gene complement(3378328..3381201) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" downshifts complement(3378345) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" CDS complement(3381209..3383194) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" gene complement(3381209..3383194) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" promotor_-10 complement(3383228..3383247) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383240) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" S_feature complement(3383242..3383327) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3383259..3383266) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3383372) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" CDS complement(3383380..3383610) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" gene complement(3383380..3383610) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" promotor_-10 complement(3383637..3383656) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3383647) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" S_feature complement(3383649..3383713) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3383670..3383677) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3383690..3383708) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3383711) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" promotor_-35 complement(3383723..3383729) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3383779) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" promotor_no_box complement(3383805..3383905) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3383845) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3383927..3383934 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3383948..3383967 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3383965 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3384057..3386552 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" gene 3384057..3386552 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" misc_feature 3386567..3386571 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3386585 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" CDS 3386628..3387197 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" gene 3386628..3387197 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" CDS 3387228..3388562 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" gene 3387228..3388562 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" downshifts 3388543 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" CDS complement(3388610..3389803) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" gene complement(3388610..3389803) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" downshifts complement(3388619) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" downshifts complement(3388684) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" S_feature complement(3389804..3389881) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3389807) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" CDS complement(3389882..3390220) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" gene complement(3389882..3390220) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo CDS complement(3390195..3390311) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" gene complement(3390195..3390311) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo S_feature complement(3390312..3390401) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3390383..3390401) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390401) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" S_feature complement(3390403..3390483) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3390415..3390420) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3390469..3390487) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390483) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3390501..3390508) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3390620..3392062) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" gene complement(3390620..3392062) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" downshifts complement(3390709) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" promotor_-10 complement(3392108..3392119) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392119) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" promotor_-35 complement(3392134..3392140) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3392202..3393092) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" gene complement(3392202..3393092) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" downshifts complement(3392219) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" CDS complement(3393085..3393771) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" gene complement(3393085..3393771) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" S_feature complement(3393772..3393904) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3393894..3393913) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3393904) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" promotor_-35 complement(3393928..3393931) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3394005..3394343) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" gene complement(3394005..3394343) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" downshifts complement(3394006) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3394370..3394389) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3394383) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" CDS complement(3394392..3395276) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" gene complement(3394392..3395276) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" promotor_-35 complement(3394403..3394410) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3395264..3395283) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3395285) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" promotor_-35 complement(3395298..3395305) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3396433..3396504), complement(3395403..3396431)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" gene complement(3395403..3396504) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" downshifts complement(3395419) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" S_feature complement(3396505..3396573) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3396574..3399099) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" gene complement(3396574..3399099) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" S_feature complement(3399100..3399180) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3399170..3399189) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3399180) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" CDS complement(3399267..3399836) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" gene complement(3399267..3399836) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" downshifts complement(3399275) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" promotor_-35 3399803..3399809 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3399822..3399841 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3399829 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3399863..3399881) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399871) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3399873..3399993) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3399893..3399901) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3399977..3399995) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399993) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" promotor_-35 complement(3400011..3400016) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400027..3400404) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" gene complement(3400027..3400404) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" CDS complement(3400414..3400755) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" gene complement(3400414..3400755) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" CDS complement(3400752..3401153) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" gene complement(3400752..3401153) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" CDS complement(3401175..3402671) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" gene complement(3401175..3402671) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" CDS complement(3402689..3403018) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" gene complement(3402689..3403018) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" downshifts 3403015 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" promotor_-10 complement(3403040..3403058) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403055) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" S_feature complement(3403057..3403161) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3403072..3403079) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3403150..3403169) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3403161) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" CDS complement(3403251..3404165) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" gene complement(3403251..3404165) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" downshifts complement(3403271) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" S_feature complement(3404166..3404274) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3404232..3404233 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3404242..3404256 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3404251 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3404253..3404271) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3404274) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" promotor_-35 complement(3404284..3404291) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3404310..3404534) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" gene complement(3404310..3404534) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" downshifts complement(3404349) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" CDS complement(3404528..3404959) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" gene complement(3404528..3404959) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" CDS complement(3404980..3405555) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" gene complement(3404980..3405555) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" CDS complement(3405602..3406498) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" gene complement(3405602..3406498) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" downshifts complement(3405625) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" misc_feature 3405914..3405917 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3405923 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3406509..3408032) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " gene complement(3406509..3408032) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" CDS complement(3408051..3408533) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" gene complement(3408051..3408533) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" CDS complement(3408549..3408815) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" gene complement(3408549..3408815) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" S_feature complement(3408816..3408895) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3408896..3409315) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" gene complement(3408896..3409315) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" promotor_-10 complement(3409354..3409372) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409365) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3409386..3409393) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3409389..3410111) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" gene complement(3409389..3410111) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" CDS complement(3410075..3410371) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" gene complement(3410075..3410371) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" promotor_-10 complement(3410397..3410416) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410410) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3410427..3410434) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3410431..3411822) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" gene complement(3410431..3411822) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" promotor_-10 complement(3411836..3411855) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411851) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" promotor_-35 complement(3411869..3411876) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3411928..3412773) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" gene complement(3411928..3412773) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" downshifts complement(3411939) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" promotor_-35 3412190..3412197 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412211..3412230 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3412221..3413953 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3412221 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" promotor_-10 complement(3412800..3412819) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412819) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" promotor_-35 complement(3412834..3412837) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3412871..3413560) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" gene complement(3412871..3413560) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" downshifts complement(3412885) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" S_feature complement(3413561..3413642) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3413643..3414800) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" gene complement(3413643..3414800) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" S_feature complement(3414801..3414928) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3414848..3414851 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414866..3414885 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3414877..3414963 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3414877 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 complement(3414922..3414941) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414928) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" promotor_-35 3414945..3414953 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3414952..3414959) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3414965 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" promotor_-10 3414967..3414975 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3415017..3415670 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " gene 3415017..3415670 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" S_feature complement(3415373..3415965) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3415670..3416845 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " gene 3415670..3416845 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" promotor_-10 complement(3415961..3415979) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3415970) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" promotor_-35 complement(3415993..3415999) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3416817 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" CDS complement(3416918..3417994) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" gene complement(3416918..3417994) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" downshifts complement(3416934) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" promotor_-35 3416980..3416989 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3417003..3417022 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3417011..3418244 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3417011 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" S_feature complement(3417995..3418077) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3418065..3418084) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3418077) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" promotor_-35 complement(3418096..3418102) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3418139..3419332) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" gene complement(3418139..3419332) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" downshifts complement(3418169) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" CDS complement(3419361..3420119) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" gene complement(3419361..3420119) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" CDS complement(3420143..3420823) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" gene complement(3420143..3420823) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" CDS complement(3420852..3422318) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" gene complement(3420852..3422318) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" S_feature complement(3422319..3422402) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3422403..3423788) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" gene complement(3422403..3423788) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" CDS complement(3423850..3425019) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" gene complement(3423850..3425019) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" CDS complement(3425016..3426467) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" gene complement(3425016..3426467) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" CDS complement(3426523..3426672) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" gene complement(3426523..3426672) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo CDS complement(3426617..3427156) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" gene complement(3426617..3427156) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo misc_feature complement(3427212..3427229) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3427216) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" CDS complement(3427383..3428873) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" gene complement(3427383..3428873) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" downshifts complement(3427405) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" CDS complement(3428912..3431029) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" gene complement(3428912..3431029) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" CDS complement(3431053..3431361) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" gene complement(3431053..3431361) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" downshifts 3431267 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" promotor_-35 3431357..3431361 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3431370..3431384 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3431371..3431389) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3431377 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3431403..3431410) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3431406) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" promotor_-35 3431427..3431435 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3431449..3431462 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3431467 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" CDS 3431545..3432465 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" gene 3431545..3432465 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" downshifts 3432455 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" CDS complement(3432505..3433647) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" gene complement(3432505..3433647) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" downshifts complement(3432529) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" promotor_-10 complement(3433686..3433705) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3433700) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" promotor_-35 complement(3433720..3433723) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3433776..3433780 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3433796..3433815 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3433797..3433892 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3433798 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" CDS 3433893..3434771 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" gene 3433893..3434771 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" S_feature 3434772..3435863 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3434841..3435196) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3435105..3435323 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" gene 3435105..3435323 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" CDS complement(3435197..3435280) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" gene complement(3435197..3435280) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo S_feature complement(3435281..3435472) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3435473..3438175) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" gene complement(3435473..3438175) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" S_feature complement(3438176..3438298) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3438197..3438203 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3438218..3438236 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3438223..3441055 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3438223 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" CDS complement(3438299..3439639) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" gene complement(3438299..3439639) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo CDS complement(3439680..3439886) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" gene complement(3439680..3439886) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo S_feature complement(3439887..3440760) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3440754..3440773) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3440760) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" S_feature complement(3440762..3441001) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3440786..3440792) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3440983..3441001) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3441001) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" promotor_-35 complement(3441015..3441022) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3441024..3441031 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3441043..3441062 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3441057..3441187 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3441057 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" promotor_no_box 3441129..3441229 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3441189 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" CDS 3441193..3441789 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" gene 3441193..3441789 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo downshifts 3441387 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" CDS complement(3441828..3443411) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" gene complement(3441828..3443411) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" downshifts 3441871 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" CDS complement(3443431..3444258) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " gene complement(3443431..3444258) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" S_feature complement(3444259..3444323) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3444319..3444338) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444323) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" S_feature complement(3444325..3444422) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3444354..3444357) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3444423..3446663) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" gene complement(3444423..3446663) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" CDS complement(3446663..3448684) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" gene complement(3446663..3448684) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" promotor_-35 3447426..3447435 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3447448..3447463 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3447459 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3448685..3448844) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3448845..3449234) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" gene complement(3448845..3449234) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" S_feature complement(3449235..3449369) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3449353..3449372) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449369) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" promotor_-35 complement(3449383..3449390) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3449524..3449530 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3449541..3449633 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3449541 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" promotor_-10 3449542..3449561 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3449634..3450404 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" gene 3449634..3450404 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" S_feature complement(3449761..3450109) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3450113..3450124) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3450117) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" promotor_-35 complement(3450139..3450145) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3450429 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" CDS 3450437..3451582 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" gene 3450437..3451582 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" downshifts 3451570 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" promotor_-35 3451624..3451631 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3451646..3451665 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3451656 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" CDS 3451702..3453030 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" gene 3451702..3453030 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" downshifts 3453025 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" downshifts complement(3453086) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" CDS complement(3453090..3455732) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" gene complement(3453090..3455732) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" promotor_-10 complement(3454335..3454354) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454337) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3454367..3454376) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3455767..3455785) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3455772) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" promotor_-35 complement(3455799..3455806) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3455861..3456811) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" gene complement(3455861..3456811) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" downshifts complement(3455873) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3456836..3456854) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456841) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" S_feature complement(3456843..3456979) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3456869..3456875) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3456953..3456972) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3456981) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" promotor_-35 3457009..3457015 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3457029..3457040 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3457029 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" CDS 3457076..3458527 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" gene 3457076..3458527 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" CDS 3458533..3459639 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" gene 3458533..3459639 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" CDS 3459636..3460760 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" gene 3459636..3460760 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" S_feature complement(3459863..3460757) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3460750 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" CDS complement(3460797..3462170) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" gene complement(3460797..3462170) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" downshifts complement(3460802) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" S_feature complement(3462171..3462234) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3462222..3462240) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462235) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" promotor_-35 complement(3462255..3462261) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3462321..3462330 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3462342..3462357 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3462344..3462464 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3462344 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" promotor_-35 3462439..3462446 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3462460..3462479 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3462466 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" CDS 3462503..3463471 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" gene 3462503..3463471 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" downshifts 3463456 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" promotor_-35 3463515..3463522 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3463537..3463556 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3463544..3463626 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3463544 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" CDS 3463627..3464487 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" gene 3463627..3464487 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" downshifts 3464468 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" CDS complement(3464521..3465762) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" gene complement(3464521..3465762) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" downshifts complement(3464540) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" promotor_-10 complement(3465784..3465802) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465806) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" promotor_-35 complement(3465815..3465822) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3465903..3466070) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" gene complement(3465903..3466070) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" downshifts complement(3465930) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" CDS complement(3466085..3467227) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" gene complement(3466085..3467227) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" CDS complement(3467246..3467695) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" gene complement(3467246..3467695) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" promotor_-35 3467389..3467395 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3467403 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" promotor_-10 3467409..3467427 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3467416..3469625 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3467710..3468891) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" gene complement(3467710..3468891) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" promotor_-35 3469605..3469612 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3469627 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" promotor_-10 3469628..3469647 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469648) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3469653..3469667) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3469675..3469679) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3469675..3470655 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" gene 3469675..3470655 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" promotor_-35 3470504..3470511 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3470525..3470544 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3470540 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" CDS 3470657..3471538 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" gene 3470657..3471538 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" CDS 3471535..3471930 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" gene 3471535..3471930 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" CDS 3471946..3473427 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" gene 3471946..3473427 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" CDS 3473429..3474397 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" gene 3473429..3474397 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" CDS 3474409..3475326 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" gene 3474409..3475326 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" promotor_-35 3475335..3475341 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3475356..3475374 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3475358 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" CDS 3475408..3475944 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" gene 3475408..3475944 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" downshifts 3475927 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" S_feature 3475972..3476082 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3476051..3476057 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3476072..3476083 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3476084 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" CDS 3476100..3476396 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" gene 3476100..3476396 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" S_feature 3476397..3477049 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3476436..3476963) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" gene complement(3476436..3476963) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" downshifts complement(3476446) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3476983..3477002) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3476996) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" downshifts 3477007 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" promotor_-35 complement(3477016..3477023) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3477062) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" CDS complement(3477063..3477830) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" gene complement(3477063..3477830) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" CDS complement(3477892..3479604) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" gene complement(3477892..3479604) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" promotor_-35 3478503..3478512 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3478526..3478545 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3478526 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3479658..3479677) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479663) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" promotor_-35 3479683..3479690 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3479692..3479696) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3479704..3479723 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3479714 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" CDS 3479762..3480670 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" gene 3479762..3480670 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" promotor_-35 3480738..3480746 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3480748..3480880 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3480748 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" promotor_-10 3480760..3480779 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3480881..3482209 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" gene 3480881..3482209 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" downshifts 3482200 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" CDS complement(3482266..3482943) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" gene complement(3482266..3482943) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" downshifts complement(3482276) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" CDS complement(3483003..3484145) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" gene complement(3483003..3484145) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" promotor_-10 complement(3484182..3484201) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484190) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" S_feature complement(3484192..3484272) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3484215..3484223) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484273..3485361) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" gene complement(3484273..3485361) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" S_feature complement(3485362..3485475) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3485417..3485426 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3485439..3485458 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3485452 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" upshifts complement(3485475) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-10 complement(3485479..3485493) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3485502..3485506) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3485502..3486089 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" gene 3485502..3486089 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" CDS 3485590..3486069 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " gene 3485590..3486069 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" S_feature complement(3485973..3486170) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3486006 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" downshifts complement(3486016) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" downshifts 3486075 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" downshifts 3486154 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" promotor_-10 complement(3486169..3486188) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486175) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" promotor_-35 3486197..3486204 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3486201..3486210) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3486219..3486238 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3486225 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" CDS 3486263..3486880 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" gene 3486263..3486880 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" S_feature 3486881..3486981 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3486938 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" promotor_-35 3487007..3487016 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487028..3487043 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487029 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3487058..3487393 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" gene 3487058..3487393 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" promotor_-10 complement(3487349..3487367) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487358) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3487382..3487387) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3487392 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" CDS complement(3487398..3488975) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" gene complement(3487398..3488975) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" S_feature 3487437..3489148 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3489126..3489133 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3489144..3489163 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3489150 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" CDS 3489189..3489665 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" gene 3489189..3489665 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" CDS 3489679..3490272 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" gene 3489679..3490272 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" CDS 3490269..3490805 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" gene 3490269..3490805 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" downshifts 3490786 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" CDS complement(3490832..3491053) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" gene complement(3490832..3491053) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" upshifts 3491000 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3491007..3491008 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3491050..3491595) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" gene complement(3491050..3491595) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" promotor_-35 3491612..3491619 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3491634..3491653 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3491638 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" CDS 3491718..3492599 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" gene 3491718..3492599 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" CDS complement(3492684..3493400) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" gene complement(3492684..3493400) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" downshifts complement(3492704) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" CDS complement(3493410..3493874) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" gene complement(3493410..3493874) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" CDS complement(3493864..3495672) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" gene complement(3493864..3495672) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" CDS complement(3495691..3495951) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" gene complement(3495691..3495951) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" CDS complement(3495961..3496383) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" gene complement(3495961..3496383) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" S_feature complement(3496384..3496466) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3496458..3496477) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496466) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" promotor_-35 complement(3496490..3496497) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3496600..3496725) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" gene complement(3496600..3496725) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" S_feature complement(3496643..3496774) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3496686) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" CDS complement(3496775..3497560) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" gene complement(3496775..3497560) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" S_feature complement(3497561..3497676) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3497669..3497688) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3497676) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" promotor_-35 complement(3497702..3497709) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3497752..3499074) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" gene complement(3497752..3499074) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" downshifts complement(3497764) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" upshifts complement(3499108) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" S_feature complement(3499110..3499235) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3499110..3499128) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3499144..3499149) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3499215..3499234) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3499235) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" CDS complement(3499269..3500033) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" gene complement(3499269..3500033) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" downshifts complement(3500052) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" CDS complement(3500086..3500799) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" gene complement(3500086..3500799) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" downshifts complement(3500103) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" CDS complement(3500789..3501535) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" gene complement(3500789..3501535) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" promotor_-10 complement(3501567..3501586) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3501579) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" promotor_-35 complement(3501603..3501606) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3501769..3501912) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" gene complement(3501769..3501912) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" downshifts complement(3501790) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" S_feature complement(3501913..3501998) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3501988..3501999) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3501998) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3502000..3502230) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3502037..3502041 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3502057..3502076 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3502066 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" CDS 3502116..3503726 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" gene 3502116..3503726 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" promotor_-10 complement(3502218..3502236) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502230) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" S_feature complement(3502232..3502406) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3502250..3502257) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3502393..3502412) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3502406) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" promotor_-35 complement(3502426..3502434) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3503713..3506481 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" gene 3503713..3506481 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" downshifts complement(3506530) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" CDS complement(3506607..3507464) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" gene complement(3506607..3507464) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" CDS complement(3507470..3508246) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" gene complement(3507470..3508246) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" promotor_-10 complement(3508272..3508291) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508294) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" S_feature complement(3508296..3508368) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3508306..3508313) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3508370..3508469) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3508413) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" CDS complement(3508470..3508811) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" gene complement(3508470..3508811) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" promotor_-10 complement(3508833..3508852) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508852) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" promotor_-35 complement(3508866..3508873) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3508888..3509271) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" gene complement(3508888..3509271) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" promotor_-10 complement(3509293..3509312) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3509300..3509319 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3509304 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3509313) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" promotor_-35 complement(3509327..3509334) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3509394..3509413 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3509397 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" downshifts complement(3509446) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" CDS 3509446..3509856 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" gene 3509446..3509856 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" S_feature 3509857..3509940 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3509898 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" CDS complement(3509996..3510304) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" gene complement(3509996..3510304) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" downshifts complement(3509997) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" CDS 3510648..3511484 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" gene 3510648..3511484 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" promotor_-35 3510864..3510871 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3510886..3510905 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3510889 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3511483 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" CDS complement(3511531..3511923) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" gene complement(3511531..3511923) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" downshifts complement(3511537) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" CDS complement(3511996..3512421) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" gene complement(3511996..3512421) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" promotor_-10 complement(3512482..3512501) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512498) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" S_feature complement(3512500..3512584) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3512516..3512523) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3512563 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" misc_feature 3512566..3512585 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3512576..3512595) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3512584) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" S_feature complement(3512586..3513670) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3512609..3512614) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3512613..3513677 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" gene 3512613..3513677 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" S_feature 3513678..3514562 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3513700..3514509) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" gene complement(3513700..3514509) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" downshifts complement(3513715) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" CDS complement(3514543..3515355) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" gene complement(3514543..3515355) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" S_feature complement(3515356..3515435) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3515386..3515393 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515407..3515426 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3515416 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3515429..3515447) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3515435) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" promotor_-35 complement(3515461..3515468) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3515518..3516519) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " gene complement(3515518..3516519) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" downshifts complement(3515524) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" misc_feature complement(3516574..3516593) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3516598) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" S_feature complement(3516600..3516684) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3516685..3516966) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" gene complement(3516685..3516966) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" CDS complement(3516981..3517091) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" gene complement(3516981..3517091) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" promotor_-10 complement(3517122..3517140) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517144) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" promotor_-35 complement(3517156..3517161) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3517237..3517243 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3517257..3517276 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3517273 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" CDS 3517316..3517729 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" gene 3517316..3517729 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" CDS 3517751..3518941 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" gene 3517751..3518941 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" CDS complement(3519032..3520438) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" gene complement(3519032..3520438) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" downshifts complement(3519329) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" promotor_-10 complement(3520471..3520490) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3520489) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" promotor_-35 complement(3520505..3520508) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3520544..3522016) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" gene complement(3520544..3522016) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" CDS complement(3522197..3523555) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" gene complement(3522197..3523555) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" downshifts complement(3522211) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" CDS complement(3523555..3524124) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" gene complement(3523555..3524124) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" promotor_-10 complement(3524143..3524154) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524161) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" promotor_-35 complement(3524168..3524174) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3524231..3524398) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" gene complement(3524231..3524398) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo CDS complement(3524308..3524772) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" gene complement(3524308..3524772) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" promotor_-10 complement(3524802..3524821) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3524807) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" promotor_-35 complement(3524835..3524842) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3524973..3524976 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3524991..3525010 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3524995 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" CDS 3525054..3526268 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" gene 3525054..3526268 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" promotor_-10 complement(3525884..3525902) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525885) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3525916..3525923) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3526134..3526140 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3526154..3526173 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3526156 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" CDS 3526280..3526630 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" gene 3526280..3526630 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" downshifts 3526623 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" promotor_-35 3526682..3526690 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3526704..3526712 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3526711 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" promotor_-35 3526753..3526762 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3526775..3526790 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3526779 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" CDS 3526811..3527392 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" gene 3526811..3527392 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" promotor_-10 complement(3526909..3526928) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526919) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3526942..3526950) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3527373 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" CDS complement(3527433..3527855) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" gene complement(3527433..3527855) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" downshifts complement(3527452) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" promotor_-10 complement(3527890..3527905) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3527909) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" promotor_-35 complement(3527918..3527927) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3527966..3528817) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" gene complement(3527966..3528817) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" downshifts complement(3527975) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" downshifts complement(3528217) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" promotor_-35 3528454..3528456 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3528473..3528492 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3528474..3528820 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3528474 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" misc_feature 3528812..3528815 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3528822..3528957 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3528822 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" upshifts complement(3528851) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" misc_feature complement(3528857..3528866) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3528958..3529449 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" gene 3528958..3529449 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" promotor_-35 3529187..3529192 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3529208..3529226 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3529219 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" S_feature complement(3529310..3530218) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3529446..3529964 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" gene 3529446..3529964 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" downshifts 3529769 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" downshifts 3529967 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" CDS 3530123..3530254 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " gene 3530123..3530254 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" CDS complement(3530251..3530685) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" gene complement(3530251..3530685) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" downshifts complement(3530263) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3530734..3530753) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3530741) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" S_feature complement(3530743..3531040) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3530768..3530775) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3530814..3530818 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3530835..3530854 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3530847..3530927 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3530848 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" CDS 3530928..3532376 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" gene 3530928..3532376 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" upshifts complement(3531040) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" promotor_-10 complement(3531041..3531059) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3531042..3531385) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3531075..3531081) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3531363..3531381) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531385) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" promotor_-35 complement(3531397..3531402) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3532365 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" CDS complement(3532397..3533170) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" gene complement(3532397..3533170) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" downshifts complement(3532419) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" promotor_-35 3533245..3533248 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3533264..3533283 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3533268 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" CDS 3533315..3533698 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" gene 3533315..3533698 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" downshifts 3533685 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" CDS complement(3533733..3534374) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" gene complement(3533733..3534374) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" downshifts complement(3533783) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" CDS complement(3534442..3534843) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" gene complement(3534442..3534843) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" promotor_-10 complement(3534892..3534911) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3534902) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" S_feature complement(3534904..3534977) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3534926..3534931) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3534978..3536687) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" gene complement(3534978..3536687) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" CDS complement(3536684..3537058) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" gene complement(3536684..3537058) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" CDS complement(3537055..3537372) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" gene complement(3537055..3537372) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" S_feature complement(3537373..3537457) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3537457) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" misc_feature complement(3537459..3537472) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3537459..3537552) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3537553..3537717) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" gene complement(3537553..3537717) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" promotor_-10 complement(3537640..3537658) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3537652) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" promotor_-35 complement(3537670..3537678) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3537718..3537889) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3537890..3538072) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" gene complement(3537890..3538072) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo S_feature complement(3538073..3538219) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3538207..3538226) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3538219) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" S_feature complement(3538221..3538334) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3538241..3538248) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" upshifts 3538348 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3538351..3538355 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3538368..3538556) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" gene complement(3538368..3538556) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" downshifts complement(3538379) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" downshifts 3538546 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3538582..3538600) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3538593) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" promotor_-35 complement(3538614..3538620) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3538629..3539129) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" gene complement(3538629..3539129) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" promotor_-10 complement(3539165..3539184) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3539172) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" promotor_-35 complement(3539198..3539204) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3539264..3540397) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" gene complement(3539264..3540397) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" downshifts complement(3539282) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" misc_feature complement(3540424..3540443) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3540431) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" promotor_-10 complement(3540494..3540512) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3540510) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" promotor_-35 complement(3540526..3540533) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3540589..3541614) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" gene complement(3540589..3541614) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" downshifts complement(3540602) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" CDS complement(3541630..3542418) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" gene complement(3541630..3542418) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" promotor_-10 complement(3542444..3542463) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542450) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" S_feature complement(3542452..3542663) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3542477..3542484) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3542664..3542825) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" gene complement(3542664..3542825) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" promotor_-10 complement(3542838..3542856) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3542858) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" promotor_-35 complement(3542870..3542876) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3542919..3543593) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" gene complement(3542919..3543593) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" downshifts complement(3542934) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" CDS complement(3543646..3543786) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" gene complement(3543646..3543786) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" CDS complement(3543917..3544600) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" gene complement(3543917..3544600) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" promotor_-35 3544977..3544981 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3544986..3546017) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" gene complement(3544986..3546017) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" promotor_-10 3544996..3545015 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3545002) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" upshifts 3545014 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3546045..3546063) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3546058) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" S_feature complement(3546060..3546177) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3546079..3546084) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3546119..3546124 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3546136..3548796 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3546136 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" promotor_-10 3546140..3546158 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3546213..3547523) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" gene complement(3546213..3547523) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" downshifts complement(3546222) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" promotor_-10 complement(3547547..3547566) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547554) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" CDS complement(3547557..3548297) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" gene complement(3547557..3548297) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" promotor_-35 complement(3547580..3547589) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3547928) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-10 complement(3547930..3547938) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3547952..3547960) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3548052..3548067) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3548060) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" promotor_-35 complement(3548080..3548089) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3548298..3548425) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3548426..3548656) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" gene complement(3548426..3548656) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" S_feature complement(3548657..3548919) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3548792..3548811 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3548798 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" CDS 3548826..3549299 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" gene 3548826..3549299 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" promotor_-10 complement(3548903..3548922) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3548919) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" S_feature complement(3548921..3549304) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3548937..3548940) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3549333..3549731) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" gene complement(3549333..3549731) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" downshifts complement(3549349) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" promotor_-10 complement(3549723..3549741) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3549732) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" promotor_-35 complement(3549755..3549761) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3549755..3551176) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" gene complement(3549755..3551176) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" CDS complement(3551202..3552065) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" gene complement(3551202..3552065) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" S_feature complement(3552066..3552141) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3552142..3553650) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" gene complement(3552142..3553650) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" CDS complement(3553667..3554212) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" gene complement(3553667..3554212) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" CDS complement(3554209..3554721) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" gene complement(3554209..3554721) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" S_feature complement(3554722..3554883) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3554884..3555096) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" gene complement(3554884..3555096) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" CDS complement(3555142..3555876) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" gene complement(3555142..3555876) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" promotor_no_box 3555690..3555790 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3555750 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3555884..3556267) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" gene complement(3555884..3556267) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" misc_feature complement(3555956..3555974) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3555958) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3556268..3556538) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3556500..3556509 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3556509 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3556514..3556533) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3556523..3556542 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556538) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" S_feature complement(3556540..3556661) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3556546..3556553) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3556690..3557319) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" gene complement(3556690..3557319) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" downshifts complement(3556706) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3557363..3557382) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3557386) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" promotor_-35 complement(3557397..3557404) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3557454..3558701) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" gene complement(3557454..3558701) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" downshifts complement(3557477) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3558743..3558762) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558760) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" S_feature complement(3558762..3558846) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3558777..3558782) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3558891) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" CDS complement(3558908..3559450) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" gene complement(3558908..3559450) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" CDS complement(3559463..3559912) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" gene complement(3559463..3559912) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" S_feature complement(3559913..3560012) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3560004..3560023) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3560012) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" promotor_-35 complement(3560037..3560044) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3560069..3560521) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" gene complement(3560069..3560521) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" promotor_-10 complement(3560538..3560557) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3560556) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" promotor_-35 complement(3560572..3560575) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3560597..3561154) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" gene complement(3560597..3561154) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" promotor_-10 complement(3561181..3561199) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3561194) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" promotor_-35 complement(3561215..3561220) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3561233..3562273) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" gene complement(3561233..3562273) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" downshifts complement(3561238) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" S_feature complement(3562274..3562338) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3562328..3562347) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3562338) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" S_feature complement(3562340..3562429) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3562363..3562367) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3562430..3562873) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" gene complement(3562430..3562873) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" CDS complement(3562940..3563614) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" gene complement(3562940..3563614) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" promotor_-10 complement(3563376..3563394) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563383) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" promotor_-35 complement(3563409..3563415) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3563646..3563663) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563647) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" promotor_-35 complement(3563679..3563684) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3563720 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" misc_feature 3563724..3563743 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3563755..3564117 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" gene 3563755..3564117 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" downshifts complement(3564130) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" CDS complement(3564134..3564421) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" gene complement(3564134..3564421) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" S_feature complement(3564422..3564480) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3564478..3564497) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3564481..3565347) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" gene complement(3564481..3565347) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" upshifts complement(3564494) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" promotor_-35 complement(3564510..3564519) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3565349..3566419) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" gene complement(3565349..3566419) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" downshifts complement(3565352) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" downshifts 3566420 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" promotor_-10 complement(3566447..3566466) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566471) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" S_feature complement(3566473..3566584) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3566480..3566486) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3566516..3566535 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3566530 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" CDS 3566545..3566931 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" gene 3566545..3566931 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" promotor_-10 complement(3566566..3566584) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3566584) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" promotor_-35 complement(3566598..3566605) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3566999..3567007 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3567018..3567036 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3567019 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" CDS 3567053..3567607 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" gene 3567053..3567607 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" misc_feature 3567537..3567541 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3567542 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3567586 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" CDS complement(3567641..3568600) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" gene complement(3567641..3568600) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" downshifts complement(3567663) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3568638..3568656) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3568652) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3568671..3568677) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3568682..3570430) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" gene complement(3568682..3570430) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" promotor_-10 complement(3569156..3569174) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569164) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3569189..3569195) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3570431..3570521) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3570505..3570524) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3570521) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" promotor_-35 complement(3570538..3570545) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3570664) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" CDS complement(3570669..3571256) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" gene complement(3570669..3571256) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" CDS complement(3571345..3571545) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" gene complement(3571345..3571545) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" downshifts complement(3571358) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" S_feature complement(3571546..3571623) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3571619..3571638) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3571623) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3571652..3571659) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3571664..3572947) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" gene complement(3571664..3572947) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" S_feature complement(3572948..3573250) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3572978..3573139) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" gene complement(3572978..3573139) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" promotor_-10 complement(3573230..3573249) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3573250) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" promotor_-35 complement(3573265..3573269) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3573354..3574319) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" gene complement(3573354..3574319) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" downshifts complement(3573360) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" promotor_-35 3573936..3573945 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3573958..3573977 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3573966 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3574350..3575639) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" gene complement(3574350..3575639) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" S_feature complement(3575640..3575999) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3576018..3576656) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" gene complement(3576018..3576656) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" downshifts complement(3576044) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" S_feature complement(3576657..3576775) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3576776..3577633) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" gene complement(3576776..3577633) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" S_feature complement(3577634..3577760) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3577742..3577761) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3577760) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" promotor_-35 complement(3577775..3577782) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3577814..3578188) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" gene complement(3577814..3578188) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" promotor_-10 complement(3578228..3578246) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3578242) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" S_feature complement(3578244..3578883) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3578245..3578248 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3578257..3578265) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3578264..3578283 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578277 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" promotor_-35 3578291..3578296 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578312..3578331 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578322 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" CDS 3578354..3578875 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" gene 3578354..3578875 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" promotor_-35 3578818..3578821 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3578836..3578855 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3578850 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3578873..3578892) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3578883) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" downshifts 3578894 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" promotor_-35 complement(3578907..3578914) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3578957..3580564) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" gene complement(3578957..3580564) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" downshifts complement(3578970) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" S_feature complement(3580565..3580752) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3580740..3580759) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3580752) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3580774..3580781) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3580806..3581327) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" gene complement(3580806..3581327) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" downshifts complement(3580862) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" S_feature complement(3581328..3581430) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3581411..3581430) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3581430) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" S_feature complement(3581432..3581509) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3581446..3581449) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3581510..3582649) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" gene complement(3581510..3582649) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" CDS complement(3582646..3584763) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" gene complement(3582646..3584763) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" S_feature complement(3584764..3584822) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3584823..3584842) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3584836) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" promotor_-35 complement(3584856..3584863) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3584862..3584868 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3584882..3584893 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3584887 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" CDS 3584918..3586114 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" gene 3584918..3586114 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" S_feature complement(3585110..3585988) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3585978..3585996) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3585989) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" promotor_-35 complement(3586012..3586017) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3586127..3587089 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" gene 3586127..3587089 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" promotor_-35 3587103..3587109 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3587124..3587142 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3587124 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" CDS 3587170..3587442 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" gene 3587170..3587442 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" downshifts complement(3587176) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" downshifts 3587432 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" S_feature 3587477..3587883 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3587484..3588008) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" gene complement(3587484..3588008) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" downshifts complement(3587506) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" CDS complement(3588018..3589745) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" gene complement(3588018..3589745) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" promotor_-10 complement(3589779..3589798) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589793) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3589812..3589818) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3589834..3591336) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" gene complement(3589834..3591336) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" promotor_-10 complement(3591360..3591378) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3591378) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" promotor_-35 complement(3591393..3591399) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3591423..3591795) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3591466) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" CDS complement(3591822..3592493) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" gene complement(3591822..3592493) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" downshifts complement(3591840) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" CDS complement(3592490..3593044) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" gene complement(3592490..3593044) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" CDS complement(3593070..3594533) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" gene complement(3593070..3594533) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" CDS complement(3594523..3598209) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" gene complement(3594523..3598209) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" misc_feature complement(3598240..3598259) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3598264) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" S_feature complement(3598266..3598395) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3598405..3598881) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" gene complement(3598405..3598881) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" downshifts complement(3598440) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" promotor_-10 complement(3598904..3598923) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3598916) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" promotor_-35 complement(3598938..3598941) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3598988 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" misc_feature 3598991..3599010 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3599025..3599744 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" gene 3599025..3599744 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" downshifts 3599728 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" CDS complement(3599776..3600492) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" gene complement(3599776..3600492) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" downshifts complement(3599778) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" downshifts complement(3599848) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" misc_feature complement(3600518..3600537) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3600530) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" CDS complement(3600591..3601778) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" gene complement(3600591..3601778) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" misc_feature complement(3601808..3601827) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3601826) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" CDS complement(3601914..3603584) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" gene complement(3601914..3603584) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" downshifts complement(3601916) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" CDS complement(3603581..3604009) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" gene complement(3603581..3604009) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" misc_feature 3604077..3604091 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3604077..3604096) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3604084 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" upshifts complement(3604093) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" promotor_-35 complement(3604113..3604116) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3604148..3604167) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3604160) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" promotor_-35 3604240..3604247 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3604255 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" promotor_-10 3604260..3604279 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3604304 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" CDS 3604322..3604453 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " gene 3604322..3604453 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" CDS 3604410..3604562 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" gene 3604410..3604562 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" downshifts 3604442 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" promotor_-35 3604557..3604563 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3604578..3604597 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3604581 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" CDS 3604587..3605933 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" gene 3604587..3605933 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" CDS 3605946..3606107 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" gene 3605946..3606107 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" CDS 3606104..3606823 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" gene 3606104..3606823 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" CDS 3606816..3608126 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" gene 3606816..3608126 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" CDS 3608116..3609276 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" gene 3608116..3609276 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" CDS 3609281..3610561 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" gene 3609281..3610561 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" CDS 3610558..3611259 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" gene 3610558..3611259 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" downshifts complement(3610826) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" S_feature complement(3610915..3611264) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3610958) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" S_feature 3611260..3613742 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3611265..3612641) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" gene complement(3611265..3612641) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" CDS complement(3612680..3614035) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" gene complement(3612680..3614035) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" promotor_-10 complement(3614071..3614090) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3614089) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" promotor_-35 complement(3614103..3614112) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3614215..3614234 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3614216 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" downshifts complement(3614261) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" CDS 3614265..3615410 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" gene 3614265..3615410 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" promotor_-35 3615269..3615273 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3615290..3615309 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3615297 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" downshifts complement(3615380) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" CDS 3615394..3615513 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" gene 3615394..3615513 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" downshifts 3615498 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" S_feature 3615543..3615611 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3615612..3616085 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" gene 3615612..3616085 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" downshifts 3616074 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" CDS complement(3616117..3616989) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" gene complement(3616117..3616989) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" downshifts complement(3616128) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" downshifts complement(3616194) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" CDS complement(3617050..3617880) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" gene complement(3617050..3617880) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" S_feature complement(3617881..3617976) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3617964..3617983) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3617975) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" promotor_-35 complement(3617996..3618003) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3618021..3618026 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3618042..3618060 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3618044 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" CDS 3618082..3620157 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" gene 3618082..3620157 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" downshifts complement(3620210) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" S_feature complement(3620334..3620449) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3620377) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" CDS complement(3620450..3620968) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" gene complement(3620450..3620968) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" CDS complement(3620982..3621641) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" gene complement(3620982..3621641) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" promotor_-35 3621664..3621667 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3621677..3621696) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3621682..3621701 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3621685 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" upshifts complement(3621695) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" S_feature complement(3621697..3621980) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3621711..3621718) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3621750..3621938 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" gene 3621750..3621938 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" downshifts 3621927 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" CDS complement(3621981..3622400) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" gene complement(3621981..3622400) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" promotor_-10 complement(3622450..3622469) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622461) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" promotor_-35 complement(3622484..3622491) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3622520..3624436) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" gene complement(3622520..3624436) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" promotor_-10 complement(3623714..3623732) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3623719) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3623749..3623753) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3624467) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" misc_RNA complement(3624490..3624711) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3624490..3624711) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" misc_RNA complement(3624743..3624964) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" gene complement(3624743..3624964) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" S_feature complement(3624996..3625258) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3625007 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" downshifts complement(3625039) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3625046..3625201) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" gene complement(3625046..3625201) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" promotor_-35 3625208..3625211 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3625220..3625233 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3625227 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3625235..3625254) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3625258) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" promotor_-35 complement(3625268..3625274) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3625281..3626681) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" gene complement(3625281..3626681) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" CDS complement(3626681..3627151) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" gene complement(3626681..3627151) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" downshifts complement(3627107) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" CDS complement(3627263..3627763) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" gene complement(3627263..3627763) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" downshifts complement(3627266) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" CDS complement(3627799..3629100) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" gene complement(3627799..3629100) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" promotor_-10 complement(3629124..3629143) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3629138) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" S_feature complement(3629140..3629261) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3629159..3629161) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3629262..3629486) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" gene complement(3629262..3629486) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" S_feature complement(3629487..3629571) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3629560..3629579) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3629570) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" promotor_-35 complement(3629594..3629597) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3629637..3629643 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3629658..3629669 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3629659 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" CDS 3629701..3630477 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" gene 3629701..3630477 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" downshifts 3630463 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" promotor_-35 3630565..3630572 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3630587..3630606 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3630591..3634817 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3630591 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" CDS complement(3630621..3631511) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" gene complement(3630621..3631511) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" promotor_no_box complement(3631511..3631611) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3631551) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" CDS complement(3631679..3632524) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" gene complement(3631679..3632524) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" downshifts complement(3631842) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" CDS complement(3632573..3633472) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" gene complement(3632573..3633472) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" promotor_-10 complement(3633515..3633534) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3633518) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" promotor_-35 complement(3633548..3633555) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3633619) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" CDS complement(3633619..3634590) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" gene complement(3633619..3634590) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" promotor_-10 complement(3634625..3634644) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3634650) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3634660..3634664) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3634738..3634749) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3634741) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" promotor_-35 complement(3634763..3634769) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3634812..3634831 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3634819 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" CDS 3634860..3635624 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" gene 3634860..3635624 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" downshifts 3635611 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" promotor_-35 3635687..3635693 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3635707..3635726 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3635716 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" CDS 3635757..3636536 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" gene 3635757..3636536 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" downshifts 3636513 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" CDS complement(3636551..3637750) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" gene complement(3636551..3637750) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" CDS complement(3637751..3638935) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" gene complement(3637751..3638935) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" CDS complement(3638932..3640350) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" gene complement(3638932..3640350) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" CDS complement(3640369..3641130) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" gene complement(3640369..3641130) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" CDS complement(3641133..3641840) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" gene complement(3641133..3641840) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" misc_feature complement(3641736..3641737) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3641737) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" CDS complement(3641830..3642444) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" gene complement(3641830..3642444) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" promotor_-35 3642002..3642008 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3642024..3642042 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3642035..3642646 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3642035 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" promotor_-10 complement(3642467..3642486) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3642483) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" promotor_-35 complement(3642501..3642508) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3642595) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" CDS complement(3642596..3643834) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" gene complement(3642596..3643834) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" promotor_-10 complement(3643876..3643895) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3643888) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" promotor_-35 complement(3643907..3643914) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3644044..3645456) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" gene complement(3644044..3645456) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" downshifts complement(3644051) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" CDS complement(3645456..3647156) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" gene complement(3645456..3647156) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" misc_feature complement(3646125..3646141) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3646137) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" CDS complement(3647230..3648777) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" gene complement(3647230..3648777) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" downshifts complement(3647237) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" upshifts complement(3648821) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" S_feature complement(3648823..3649003) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3648824..3648842) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3649004..3650278) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" gene complement(3649004..3650278) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" S_feature complement(3650279..3650361) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3650361) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" misc_feature complement(3650374..3650392) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3650454) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" CDS complement(3650455..3650919) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" gene complement(3650455..3650919) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" S_feature complement(3650920..3651030) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3651012..3651031) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3651030) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" promotor_-35 complement(3651046..3651053) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3651241) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" CDS complement(3651243..3651698) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" gene complement(3651243..3651698) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" misc_feature 3651333..3651352 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3651341 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3651691..3652542) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" gene complement(3651691..3652542) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" CDS complement(3652556..3653503) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" gene complement(3652556..3653503) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" CDS complement(3653503..3654243) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" gene complement(3653503..3654243) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" promotor_-35 3654261..3654266 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3654267 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3654268..3655287) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" gene complement(3654268..3655287) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" promotor_-10 3654281..3654299 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3655151..3655160 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3655173..3655188 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3655184 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3655290..3656012) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" gene complement(3655290..3656012) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" CDS complement(3656005..3657126) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" gene complement(3656005..3657126) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" CDS complement(3657126..3657995) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" gene complement(3657126..3657995) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" CDS complement(3657996..3659165) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" gene complement(3657996..3659165) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" CDS complement(3659186..3660610) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" gene complement(3659186..3660610) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" CDS complement(3660615..3661385) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" gene complement(3660615..3661385) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" promotor_-10 complement(3661420..3661439) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661434) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" promotor_-35 complement(3661453..3661462) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3661553..3661558 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3661574..3661592 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3661576..3661704 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3661576 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" CDS 3661705..3662250 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" gene 3661705..3662250 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" downshifts 3662236 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" CDS complement(3662294..3662665) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" gene complement(3662294..3662665) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" downshifts complement(3662312) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" CDS complement(3662727..3664049) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" gene complement(3662727..3664049) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" CDS complement(3664069..3664386) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" gene complement(3664069..3664386) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" promotor_-10 complement(3664415..3664434) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664426) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" promotor_-35 complement(3664448..3664454) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3664489..3664496 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3664512..3664531 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3664515 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" CDS 3664554..3665924 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" gene 3664554..3665924 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" CDS complement(3665949..3666626) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" gene complement(3665949..3666626) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" downshifts complement(3665963) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3666453..3666472) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666469) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3666488..3666493) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3666640..3667446) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" gene complement(3666640..3667446) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" promotor_-10 complement(3666939..3666957) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666953) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" promotor_-35 complement(3666972..3666978) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3667475..3667494) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3667481) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" promotor_-35 complement(3667510..3667517) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3667536..3668069) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" gene complement(3667536..3668069) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" CDS complement(3668117..3668752) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" gene complement(3668117..3668752) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" CDS complement(3668745..3669083) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" gene complement(3668745..3669083) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" promotor_-10 complement(3669105..3669124) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669116) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" promotor_-35 complement(3669139..3669146) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3669167..3669170 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3669185..3669204 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3669185 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" CDS 3669227..3670042 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" gene 3669227..3670042 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" downshifts 3670021 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" downshifts complement(3670097) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" CDS complement(3670132..3670380) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" gene complement(3670132..3670380) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" downshifts complement(3670152) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" upshifts complement(3670398) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" S_feature complement(3670400..3670473) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3670408..3670414) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3670474..3671913) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" gene complement(3670474..3671913) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" CDS complement(3671910..3673295) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" gene complement(3671910..3673295) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" misc_feature complement(3673314..3673323) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3673328) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" S_feature complement(3673330..3673394) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3673373..3673390) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673394) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3673406..3673413) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3673436..3673455) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3673454) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" promotor_-35 complement(3673469..3673476) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3673535..3673538 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3673545 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" promotor_-10 3673553..3673572 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3673597..3674367 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" gene 3673597..3674367 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" S_feature 3674368..3675435 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3674406..3675236) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" gene complement(3674406..3675236) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" downshifts complement(3674407) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" promotor_-10 complement(3675262..3675281) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3675268) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" CDS complement(3675276..3675578) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" gene complement(3675276..3675578) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" promotor_-35 complement(3675296..3675303) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3675579..3675717) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3675702..3675721) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3675717) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" promotor_-35 3676032..3676040 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3676051..3676069 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3676052 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" CDS 3676108..3678528 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" gene 3676108..3678528 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" upshifts 3676266 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3676275..3676294 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3678516 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" CDS complement(3678566..3679567) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " gene complement(3678566..3679567) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" S_feature complement(3679568..3679729) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3679741..3680490) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" gene complement(3679741..3680490) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" downshifts complement(3679774) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" promotor_-10 complement(3680508..3680527) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3680525) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" promotor_-35 complement(3680542..3680545) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3680596..3681777) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" gene complement(3680596..3681777) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" downshifts complement(3680610) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" S_feature complement(3681778..3681909) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3681903..3681918) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3681909) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" promotor_-35 complement(3681930..3681939) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3682144..3682151 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3682162..3682272 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3682162..3682181 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3682162 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" CDS 3682273..3682536 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" gene 3682273..3682536 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" downshifts 3682426 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" downshifts 3682542 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" CDS complement(3682579..3682953) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" gene complement(3682579..3682953) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" downshifts complement(3682590) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" CDS complement(3682955..3683569) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" gene complement(3682955..3683569) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" CDS complement(3683583..3685532) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" gene complement(3683583..3685532) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" misc_feature 3684796..3684815 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3684802 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_no_box 3685226..3685326 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3685286 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3685396 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" CDS complement(3685560..3686525) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" gene complement(3685560..3686525) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" S_feature complement(3686526..3686594) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3686581..3686600) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686594) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3686596..3686781) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3686613..3686617) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3686712..3686717 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3686733..3686751 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3686738 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3686772..3686791) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686781) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" S_feature complement(3686783..3686892) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3686806..3686810) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3686848 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" promotor_-10 complement(3686877..3686896) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686892) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-35 complement(3686912..3686916) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3686970..3686988) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3686975..3686981 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3686987) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" promotor_-10 3686996..3687014 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3686999 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" promotor_-35 complement(3687004..3687009) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3687041..3687286 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" gene 3687041..3687286 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" downshifts 3687268 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" CDS complement(3687357..3688898) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" gene complement(3687357..3688898) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" downshifts complement(3687386) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" CDS complement(3688902..3690074) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" gene complement(3688902..3690074) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" promotor_-10 complement(3690092..3690110) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3690114) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3690125..3690131) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3690155..3690538) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" gene complement(3690155..3690538) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" CDS complement(3690556..3691227) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" gene complement(3690556..3691227) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" promotor_-10 complement(3691249..3691268) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3691258) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" promotor_-35 complement(3691284..3691287) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3691368..3691371 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3691386..3691405 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3691395..3691582 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3691395 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" CDS 3691583..3691741 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" gene 3691583..3691741 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" S_feature 3691742..3692126 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3692107..3692112 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3692128..3692146 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3692128 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" CDS 3692184..3692492 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" gene 3692184..3692492 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" downshifts complement(3692270) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3692274..3692374) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3692314) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3692489..3694030 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" gene 3692489..3694030 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" downshifts 3694021 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" CDS complement(3694061..3694663) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" gene complement(3694061..3694663) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" downshifts complement(3694075) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" S_feature complement(3694664..3694945) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3694946..3696196) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" gene complement(3694946..3696196) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" downshifts complement(3695042) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" CDS complement(3696215..3697372) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" gene complement(3696215..3697372) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" misc_feature complement(3696288..3696307) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3696315) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" CDS complement(3697369..3698814) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" gene complement(3697369..3698814) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" promotor_-10 complement(3698848..3698867) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698858) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" promotor_-35 complement(3698881..3698888) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3698971..3699639) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" gene complement(3698971..3699639) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" downshifts complement(3698980) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" CDS complement(3699636..3700454) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" gene complement(3699636..3700454) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" CDS complement(3700462..3701367) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" gene complement(3700462..3701367) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" misc_feature complement(3701102..3701121) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3701113) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" promotor_-10 complement(3701408..3701427) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3701418..3701425 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3701429) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" upshifts 3701437 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" promotor_-10 3701439..3701458 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3701443..3701450) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3701473..3701859 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" gene 3701473..3701859 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" CDS 3701841..3702518 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" gene 3701841..3702518 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" downshifts 3702490 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" promotor_-35 3702562..3702569 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3702580 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" promotor_-10 3702583..3702602 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3702622..3703821 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" gene 3702622..3703821 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" CDS 3703855..3704052 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" gene 3703855..3704052 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" downshifts 3704031 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" CDS complement(3704088..3705278) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" gene complement(3704088..3705278) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" downshifts complement(3704103) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" downshifts complement(3704187) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" misc_feature complement(3705302..3705321) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3705318) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" promotor_-35 3705338..3705345 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3705354 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" promotor_-10 3705359..3705378 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3705399..3705779 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" gene 3705399..3705779 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" downshifts 3705677 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" downshifts 3705748 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" CDS complement(3705817..3706494) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" gene complement(3705817..3706494) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" downshifts complement(3705824) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3706503..3706522) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3706528) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" promotor_-35 complement(3706534..3706540) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3706571..3707905) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" gene complement(3706571..3707905) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" misc_feature complement(3707953..3707971) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3707976) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" promotor_-35 3708070..3708077 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3708082 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" promotor_-10 3708091..3708109 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3708133..3710070 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" gene 3708133..3710070 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" promotor_-10 complement(3709277..3709296) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3709278) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3709310..3709318) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3710060 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" promotor_-35 3710173..3710180 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3710195..3710214 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3710214 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3710426..3710433 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3710446..3710465 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3710446 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" CDS 3710498..3711877 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" gene 3710498..3711877 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" S_feature complement(3711586..3712789) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3711931..3712773 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" gene 3711931..3712773 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" CDS complement(3712824..3713684) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" gene complement(3712824..3713684) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" downshifts complement(3712834) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" downshifts 3713668 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" promotor_-10 complement(3713706..3713724) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3713724) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" promotor_-35 complement(3713739..3713745) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3713794..3714507) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" gene complement(3713794..3714507) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" promotor_-35 3713909..3713910 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3713930..3713947 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3713932 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3714535..3714546) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714536) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3714561..3714567) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3714582..3714588 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3714603..3714622 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3714613 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" CDS 3714658..3715173 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" gene 3714658..3715173 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" misc_RNA 3715174..3715380 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" gene 3715174..3715380 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" downshifts 3715340 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" CDS 3715422..3716663 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" gene 3715422..3716663 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" promotor_-35 3716754..3716762 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3716773..3716791 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3716784 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" CDS 3716819..3718186 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" gene 3716819..3718186 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" downshifts 3718163 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" CDS complement(3718216..3718848) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" gene complement(3718216..3718848) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" downshifts complement(3718234) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3718884..3718899) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3718892) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" promotor_-35 complement(3718912..3718920) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3718990..3719925) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" gene complement(3718990..3719925) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" downshifts complement(3719002) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" promotor_-35 3719669..3719678 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3719692..3719711 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3719696 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3719926..3720013) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3719996..3720015) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3720013) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3720031..3720035) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3720058..3720070) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3720058) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" promotor_-35 complement(3720085..3720091) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3720088..3720222) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" gene complement(3720088..3720222) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" promotor_-35 3720169..3720176 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3720190..3720209 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3720199 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" S_feature 3720202..3720306 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3720301..3720310 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3720308 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" promotor_-10 3720322..3720337 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3720344) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3720346..3720360) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3720372..3720521 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" gene 3720372..3720521 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" CDS 3720539..3722050 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" gene 3720539..3722050 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" CDS 3722047..3723234 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" gene 3722047..3723234 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" CDS 3723251..3723487 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" gene 3723251..3723487 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" CDS 3723487..3724665 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" gene 3723487..3724665 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" S_feature 3724666..3724755 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3724756..3725514 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" gene 3724756..3725514 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" downshifts 3725482 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" S_feature complement(3725516..3726743) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3725562..3725569 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3725583..3725602 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3725596 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" CDS 3725655..3726746 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" gene 3725655..3726746 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" downshifts 3726648 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" downshifts 3726736 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" CDS complement(3726780..3728108) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" gene complement(3726780..3728108) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" downshifts complement(3726788) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" CDS complement(3728105..3728437) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" gene complement(3728105..3728437) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" CDS complement(3728456..3729814) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" gene complement(3728456..3729814) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" CDS complement(3729830..3730138) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" gene complement(3729830..3730138) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" promotor_-10 complement(3730183..3730202) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3730199) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" promotor_-35 complement(3730216..3730222) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3730267) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" CDS complement(3730267..3732192) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" gene complement(3730267..3732192) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" promotor_-35 3730930..3730939 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3730953..3730972 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3730961 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3732265..3732282) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3732289) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" promotor_-35 complement(3732297..3732304) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3732355..3732513) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" gene complement(3732355..3732513) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" downshifts complement(3732382) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" CDS complement(3732542..3733132) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" gene complement(3732542..3733132) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" promotor_-10 complement(3733160..3733178) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3733171) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" promotor_-35 complement(3733192..3733198) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3733201..3733207 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3733223..3733241 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3733226 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" CDS 3733261..3734904 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" gene 3733261..3734904 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" S_feature complement(3733398..3734947) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3734899 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" S_feature complement(3734949..3735040) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3734951..3734957 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3734965 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3734972..3734991 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3734992) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" CDS 3735009..3736211 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" gene 3735009..3736211 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" S_feature complement(3735042..3736207) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3735085) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" CDS complement(3736208..3736984) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" gene complement(3736208..3736984) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" CDS complement(3736981..3737868) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" gene complement(3736981..3737868) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" CDS complement(3737875..3738063) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" gene complement(3737875..3738063) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" CDS complement(3738060..3738266) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" gene complement(3738060..3738266) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" CDS complement(3738263..3738583) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" gene complement(3738263..3738583) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" promotor_-35 3738396..3738405 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3738418..3738437 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3738420 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3738576..3739112) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" gene complement(3738576..3739112) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" upshifts complement(3739140) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" promotor_-10 complement(3739141..3739156) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3739168..3739177) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3739243..3739250 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3739264..3739283 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3739273 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" CDS 3739324..3740697 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" gene 3739324..3740697 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" S_feature complement(3739604..3740146) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3740134..3740153) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3740146) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3740168..3740175) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3740532 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" CDS complement(3740712..3741542) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" gene complement(3740712..3741542) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" downshifts complement(3740718) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" promotor_-10 complement(3741561..3741579) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3741576) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" promotor_-35 complement(3741594..3741600) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3741620) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature complement(3741622..3741641) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3741628..3743355) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" gene complement(3741628..3743355) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" downshifts complement(3741727) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" CDS complement(3743352..3745055) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" gene complement(3743352..3745055) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" CDS complement(3745055..3746071) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" gene complement(3745055..3746071) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" promotor_-10 complement(3745945..3745963) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3745954) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" promotor_-35 complement(3745979..3745984) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3746055..3747461) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" gene complement(3746055..3747461) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" S_feature complement(3747462..3747670) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3747653..3747672) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3747670) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" S_feature complement(3747672..3747780) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3747686..3747691) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3747777..3747796) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3747792) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" promotor_-35 complement(3747810..3747817) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3747938..3747945 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3747955 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" promotor_-10 3747960..3747978 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3748017..3749369 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" gene 3748017..3749369 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" S_feature complement(3748968..3751450) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3749354 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" misc_feature 3749445..3749464 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3749451 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" CDS 3749491..3751179 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" gene 3749491..3751179 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" promotor_-35 3751177..3751186 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3751198..3751213 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3751202 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" CDS 3751237..3751437 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" gene 3751237..3751437 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" S_feature 3751438..3752382 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3751451..3752290) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" gene complement(3751451..3752290) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" promotor_-10 complement(3752316..3752334) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3752334) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" promotor_-35 complement(3752347..3752354) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3752349 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" CDS complement(3752397..3753494) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" gene complement(3752397..3753494) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" downshifts complement(3752398) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" promotor_-10 complement(3753527..3753546) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3753544) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" S_feature complement(3753546..3753614) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3753559..3753566) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3753615..3754508) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" gene complement(3753615..3754508) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" promotor_-10 complement(3754535..3754554) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754554) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" promotor_-35 complement(3754568..3754575) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3754582..3754587 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3754603..3754621 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3754612 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3754629..3754635 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3754650..3754668 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3754656 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" CDS 3754692..3756149 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" gene 3754692..3756149 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" promotor_-10 complement(3755575..3755593) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3755590) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3755608..3755613) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3756130 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" downshifts 3756174 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" CDS complement(3756191..3757027) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" gene complement(3756191..3757027) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" downshifts complement(3756209) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" misc_RNA complement(3757104..3757206) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" gene complement(3757104..3757206) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" downshifts complement(3757130) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3757232..3757251) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3757243) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" S_feature complement(3757245..3757986) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3757265..3757271) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3757323..3757330 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3757343..3757361 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3757352 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" S_feature 3757362..3757447 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3757423..3757430 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3757444..3757463 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3757449 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" CDS 3757595..3758137 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" gene 3757595..3758137 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" promotor_-10 complement(3757962..3757981) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3757986) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" promotor_-35 complement(3757995..3758004) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3758127 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" S_feature 3758172..3758494 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3758212..3759231) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" gene complement(3758212..3759231) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" downshifts complement(3758230) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3759257..3759276) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759271) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" promotor_-35 complement(3759291..3759294) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3759346..3759852) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" gene complement(3759346..3759852) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" promotor_-10 complement(3759858..3759877) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759880) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" promotor_-35 3759882..3759885 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3759891..3759897) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3759900..3759919 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3759903 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" CDS 3759982..3760857 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" gene 3759982..3760857 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" S_feature complement(3760232..3760320) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3760254) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3760280..3760380) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3760320) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" CDS 3760935..3761408 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" gene 3760935..3761408 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" CDS 3761426..3762646 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" gene 3761426..3762646 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" CDS 3762633..3763289 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" gene 3762633..3763289 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" promotor_-35 3763287..3763292 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3763306..3763325 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3763309 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" CDS 3763339..3764571 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" gene 3763339..3764571 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" downshifts complement(3763356) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" downshifts 3764556 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" promotor_-35 3764617..3764626 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3764639..3764654 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3764641..3764863 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3764641 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3764820 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" promotor_-35 3764874..3764880 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3764893..3764993 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3764893 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" promotor_-10 3764895..3764913 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3764972..3764979 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3764993..3765011 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3764995..3765092 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3764995 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" CDS 3765093..3765356 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" gene 3765093..3765356 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" promotor_-35 3765120..3765123 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3765138..3765157 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3765150 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" downshifts 3765304 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" downshifts 3765348 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" promotor_-35 3765423..3765432 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3765438 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" promotor_-10 3765444..3765459 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3765485..3765973 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" gene 3765485..3765973 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" promotor_-35 3765978..3765985 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3765999..3766018 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3766009 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3766039..3766145 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3766039..3766145 /gene="mswI" /locus_tag="BSU_misc_RNA_61" downshifts 3766140 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" CDS 3766228..3767361 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" gene 3766228..3767361 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" S_feature complement(3766501..3766744) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3766739..3766758) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3766748) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" promotor_-35 complement(3766773..3766780) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3767367..3767374 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3767389..3767408 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3767395 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" misc_RNA 3767430..3767536 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" gene 3767430..3767536 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" downshifts 3767483 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" S_feature 3767537..3767613 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3767614..3768750 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" gene 3767614..3768750 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" downshifts 3768737 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" CDS complement(3768803..3769576) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" gene complement(3768803..3769576) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" downshifts complement(3768813) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" CDS complement(3769593..3770243) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" gene complement(3769593..3770243) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" CDS complement(3770240..3770956) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" gene complement(3770240..3770956) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" CDS complement(3770980..3772398) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" gene complement(3770980..3772398) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" promotor_-10 complement(3771566..3771584) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3771585) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3771600..3771605) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3772399..3772483) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3772467..3772485) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3772483) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" promotor_-35 complement(3772501..3772506) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3772552..3773400) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" gene complement(3772552..3773400) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" downshifts complement(3772562) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" S_feature complement(3773401..3773586) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3773575..3773594) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3773586) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" S_feature complement(3773588..3774313) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3773610..3773614) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3773748..3773755 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3773768..3773787 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3773777 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" misc_RNA 3773787..3773889 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" gene 3773787..3773889 /gene="gswB" /locus_tag="BSU_misc_RNA_63" S_feature 3773890..3773993 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3773965..3773971 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3773985..3773996 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3773995 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" CDS 3774016..3775209 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" gene 3774016..3775209 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" promotor_-10 complement(3774300..3774318) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774316) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" promotor_-35 complement(3774331..3774338) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3774985 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" downshifts 3775205 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" CDS complement(3775251..3775679) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" gene complement(3775251..3775679) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo CDS complement(3775680..3775922) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" gene complement(3775680..3775922) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo S_feature complement(3775923..3775986) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3775975..3775990) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3775986) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" promotor_-35 complement(3776002..3776011) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3776019 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" CDS complement(3776067..3776357) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" gene complement(3776067..3776357) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" downshifts complement(3776073) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3776382..3776401) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3776399) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" CDS complement(3776407..3778467) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" gene complement(3776407..3778467) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" promotor_-35 complement(3776415..3776422) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3778496..3778514) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3778500) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" promotor_-35 complement(3778529..3778535) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3778560..3778565 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3778579 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" promotor_-10 3778581..3778599 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3778593..3778667 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3778668..3779948 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" gene 3778668..3779948 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" S_feature 3779949..3780088 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3780045 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" CDS complement(3780106..3780834) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" gene complement(3780106..3780834) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" downshifts complement(3780123) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" promotor_-10 complement(3780865..3780884) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3780876) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" promotor_-35 complement(3780898..3780905) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3781022..3781129) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3781065) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" CDS complement(3781130..3781963) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" gene complement(3781130..3781963) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" promotor_-10 complement(3781994..3782013) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3782013) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" promotor_-35 complement(3782027..3782034) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3782059..3782739) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" gene complement(3782059..3782739) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" promotor_-10 complement(3782786..3782805) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3782795) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" promotor_-35 complement(3782819..3782826) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3782887..3782890 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3782905..3782924 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3782905 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" CDS 3782946..3784232 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" gene 3782946..3784232 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" promotor_-10 complement(3783677..3783695) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3783685) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3783709..3783716) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3784203 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" CDS complement(3784251..3785690) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" gene complement(3784251..3785690) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" downshifts complement(3784274) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" misc_feature complement(3785714..3785733) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3785731) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" CDS complement(3785772..3786920) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" gene complement(3785772..3786920) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" promotor_-10 complement(3786947..3786963) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3786963) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" S_feature complement(3786965..3787049) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3786978..3786983) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3787050..3787238) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" gene complement(3787050..3787238) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo CDS complement(3787269..3787400) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " gene complement(3787269..3787400) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" CDS complement(3787412..3787873) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" gene complement(3787412..3787873) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" CDS complement(3787889..3788185) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" gene complement(3787889..3788185) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" CDS complement(3788213..3788701) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" gene complement(3788213..3788701) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" CDS complement(3788719..3789171) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" gene complement(3788719..3789171) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" S_feature complement(3789172..3789240) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3789241..3789570) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" gene complement(3789241..3789570) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" S_feature complement(3789571..3789692) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3789693..3790109) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" gene complement(3789693..3790109) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" CDS complement(3790160..3790528) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" gene complement(3790160..3790528) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" CDS complement(3790522..3790992) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" gene complement(3790522..3790992) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" S_feature complement(3790993..3791317) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3791318..3791746) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" gene complement(3791318..3791746) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" CDS complement(3791808..3798812) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" gene complement(3791808..3798812) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" misc_feature 3798819..3798833 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3798833 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3798843..3798862) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3798858) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" promotor_-35 complement(3798877..3798884) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3798974..3799909) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" gene complement(3798974..3799909) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" downshifts complement(3799195) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" S_feature complement(3799910..3800030) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3800061..3800507) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" gene complement(3800061..3800507) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" downshifts complement(3800075) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3800544..3800563) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3800551) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" promotor_-35 complement(3800577..3800584) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3800610..3802019) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" gene complement(3800610..3802019) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" CDS complement(3802042..3803871) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" gene complement(3802042..3803871) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" promotor_no_box complement(3803863..3803963) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3803903) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" S_feature complement(3803905..3804097) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3804078..3804097) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3804097) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" S_feature complement(3804099..3804232) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3804110..3804117) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3804254..3804562) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" gene complement(3804254..3804562) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" downshifts complement(3804277) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" CDS complement(3804608..3805051) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" gene complement(3804608..3805051) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" CDS complement(3805048..3806757) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" gene complement(3805048..3806757) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" misc_feature complement(3805919..3805938) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3805927) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" CDS complement(3806777..3807046) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" gene complement(3806777..3807046) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" CDS complement(3807058..3807423) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" gene complement(3807058..3807423) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" S_feature complement(3807424..3807489) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3807476..3807495) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3807489) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" promotor_-35 complement(3807510..3807513) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3807730..3809139) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" gene complement(3807730..3809139) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" downshifts complement(3807753) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" S_feature complement(3809140..3809249) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3809273..3809437) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" gene complement(3809273..3809437) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" promotor_-10 complement(3809322..3809340) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809337) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3809351..3809359) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3809629..3809648) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809645) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3809661..3809668) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3809677..3809684 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3809699..3809718 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3809702 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" CDS 3809756..3810202 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" gene 3809756..3810202 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" downshifts 3810207 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" CDS 3810315..3811841 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" gene 3810315..3811841 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" CDS 3811838..3813496 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" gene 3811838..3813496 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" CDS 3813509..3814774 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" gene 3813509..3814774 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" CDS 3814767..3815726 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" gene 3814767..3815726 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" S_feature 3815727..3815801 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3815802..3817229 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" gene 3815802..3817229 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" downshifts 3817225 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" CDS complement(3817273..3818574) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" gene complement(3817273..3818574) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" downshifts complement(3817290) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" CDS complement(3818604..3819785) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" gene complement(3818604..3819785) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" S_feature complement(3819786..3819865) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3819866..3820537) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" gene complement(3819866..3820537) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" promotor_-35 3820486..3820489 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3820504 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3820505..3820524 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3820565..3820584) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3820580) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" promotor_-35 complement(3820598..3820605) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3820643..3821584) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" gene complement(3820643..3821584) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" promotor_-10 complement(3821629..3821648) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3821635) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" S_feature complement(3821637..3821717) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3821664..3821667) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3821718..3822545) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " gene complement(3821718..3822545) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" downshifts complement(3822517) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" promotor_-10 complement(3822570..3822588) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3822583) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" promotor_-35 complement(3822602..3822608) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3822618..3823730) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" gene complement(3822618..3823730) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" CDS complement(3823800..3825137) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" gene complement(3823800..3825137) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" CDS complement(3825134..3826276) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" gene complement(3825134..3826276) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" CDS complement(3826293..3827042) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" gene complement(3826293..3827042) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" CDS complement(3827055..3827729) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" gene complement(3827055..3827729) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" CDS complement(3827752..3828546) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" gene complement(3827752..3828546) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" promotor_-35 3828118..3828127 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3828139 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3828140..3828155 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3828571..3829068) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" gene complement(3828571..3829068) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" CDS complement(3829082..3830407) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" gene complement(3829082..3830407) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" promotor_-10 complement(3830484..3830503) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3830488) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" promotor_-35 complement(3830517..3830524) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3830593..3830820) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" gene complement(3830593..3830820) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" CDS complement(3830807..3831793) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" gene complement(3830807..3831793) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" downshifts complement(3830811) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" promotor_-35 3830944..3830953 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3830967..3830986 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3830977..3831610 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3830977 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" promotor_-10 complement(3831848..3831867) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3831859) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" promotor_-35 complement(3831882..3831889) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3831948..3832760) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" gene complement(3831948..3832760) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" promotor_-10 complement(3832790..3832809) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3832800..3833357) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" gene complement(3832800..3833357) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" upshifts complement(3832813) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3832824..3832831) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3833338..3833772) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" gene complement(3833338..3833772) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" promotor_-35 3833797..3833806 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3833816 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" promotor_-10 3833819..3833838 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3833832) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" S_feature complement(3833833..3834244) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3833838..3833852) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3833861..3833865) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3833861..3834226 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" gene 3833861..3834226 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" downshifts 3834240 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" promotor_-10 complement(3834244..3834248) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3834244) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" S_feature complement(3834246..3834332) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-35 complement(3834269) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3834325..3834344) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3834332) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" promotor_-35 complement(3834358..3834365) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3834405..3834411 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3834425..3834436 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3834432 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" CDS 3834474..3834827 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" gene 3834474..3834827 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" downshifts 3834822 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" CDS complement(3834871..3835269) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" gene complement(3834871..3835269) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" downshifts complement(3834879) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" promotor_-10 complement(3835284..3835303) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3835300) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" promotor_-35 complement(3835318..3835321) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3835357..3835364 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3835373..3835391) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3835379..3835398 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3835388 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" upshifts complement(3835388) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3835407..3835412) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3835447..3836412 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" gene 3835447..3836412 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" upshifts 3835840 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" misc_feature 3835847..3835865 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3836319 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" downshifts 3836390 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" S_feature 3836435..3837231 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3836453..3836800) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" gene complement(3836453..3836800) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" downshifts complement(3836466) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" CDS complement(3836814..3838682) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" gene complement(3836814..3838682) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" CDS complement(3838657..3839430) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" gene complement(3838657..3839430) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" CDS complement(3839574..3840551) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" gene complement(3839574..3840551) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" CDS complement(3840548..3841237) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" gene complement(3840548..3841237) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" promotor_-10 complement(3841264..3841283) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3841282) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" promotor_-35 complement(3841298..3841304) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3841345..3842217) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" gene complement(3841345..3842217) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" downshifts complement(3841349) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" CDS complement(3842238..3843074) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" gene complement(3842238..3843074) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" S_feature complement(3843075..3843159) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3843160..3844029) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" gene complement(3843160..3844029) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" CDS complement(3844049..3845083) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" gene complement(3844049..3845083) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" CDS complement(3845106..3846422) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" gene complement(3845106..3846422) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" CDS complement(3846437..3847330) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" gene complement(3846437..3847330) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" CDS complement(3847347..3849260) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" gene complement(3847347..3849260) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" CDS complement(3849293..3850270) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" gene complement(3849293..3850270) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" CDS complement(3850294..3851109) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" gene complement(3850294..3851109) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" S_feature complement(3851110..3851183) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3851184..3852647) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" gene complement(3851184..3852647) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" S_feature complement(3852648..3852852) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3852651..3852658 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3852674..3852693 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3852681 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" S_feature 3852688..3852994 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3852834..3852853) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3852852) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" S_feature complement(3852854..3853006) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3852868..3852875) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3852954..3852961 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3852976..3852995 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3852996 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" promotor_-10 complement(3853007..3853026) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3853023) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" promotor_-35 complement(3853042..3853049) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3853063..3853818 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" gene 3853063..3853818 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" promotor_-35 3853797..3853803 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3853818..3853837 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3853832 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3853872..3854804 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" gene 3853872..3854804 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" downshifts 3854806 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" promotor_-35 3854883..3854890 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3854904..3854923 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3854910..3855065 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3854910 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" CDS 3855066..3855716 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" gene 3855066..3855716 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" CDS 3855720..3856028 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" gene 3855720..3856028 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" downshifts 3856030 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" promotor_-35 3856172..3856178 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3856194..3856212 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3856204 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" CDS 3856266..3857651 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" gene 3856266..3857651 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" downshifts 3857637 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" S_feature 3857682..3858232 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3857693..3859573) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" gene complement(3857693..3859573) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" downshifts complement(3857699) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" S_feature complement(3859574..3859671) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3859662..3859681) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3859671) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" promotor_-35 complement(3859696..3859703) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3859741..3859992) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" gene complement(3859741..3859992) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" downshifts complement(3859759) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" misc_feature complement(3860014..3860033) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3860023) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" promotor_-35 3860056..3860062 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3860076..3860094 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3860077 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" CDS 3860109..3860930 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" gene 3860109..3860930 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" downshifts 3860914 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" CDS complement(3860959..3862101) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" gene complement(3860959..3862101) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" downshifts complement(3860969) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" S_feature complement(3862102..3862201) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3862189..3862208) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3862200) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" promotor_-35 complement(3862222..3862229) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3862244..3863581 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" gene 3862244..3863581 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" S_feature complement(3862986..3863586) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3863620..3864099) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " gene complement(3863620..3864099) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" downshifts complement(3863631) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" CDS complement(3864179..3865171) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" gene complement(3864179..3865171) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" downshifts complement(3864203) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" downshifts 3865161 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" promotor_-10 complement(3865194..3865213) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3865212) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" promotor_-35 complement(3865228..3865235) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3865234..3865241 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3865255..3865679 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3865255 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" promotor_-10 3865256..3865275 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3865261..3865673 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" gene 3865261..3865673 /gene="srlX" /locus_tag="BSU_misc_RNA_86" upshifts complement(3865281) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3865291..3865305) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3865313..3865317) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3865645 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" CDS 3865680..3866414 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" gene 3865680..3866414 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" CDS 3866414..3866683 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" gene 3866414..3866683 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" CDS 3866687..3867169 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" gene 3866687..3867169 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" CDS 3867190..3869433 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" gene 3867190..3869433 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" CDS 3869430..3870629 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" gene 3869430..3870629 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" promotor_-10 complement(3870385..3870403) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3870407) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3870418..3870424) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3870620 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" downshifts complement(3870693) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" CDS complement(3870693..3871925) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" gene complement(3870693..3871925) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" promotor_-10 complement(3871957..3871976) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3871969) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3871990..3871995) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3872026..3872451) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" gene complement(3872026..3872451) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" promotor_-10 complement(3872479..3872498) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3872493) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" promotor_-35 complement(3872511..3872517) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3872643..3872650 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3872660 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" promotor_-10 3872665..3872684 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3872708..3873163 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" gene 3872708..3873163 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" downshifts 3873101 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" S_feature 3873164..3873777 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3873193..3874401) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" gene complement(3873193..3874401) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" downshifts complement(3873220) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" S_feature complement(3874402..3874508) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3874509..3875522) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" gene complement(3874509..3875522) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" S_feature complement(3875523..3875596) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3875581..3875600) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3875596) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" promotor_-35 complement(3875613..3875620) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3875616..3876191) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" gene complement(3875616..3876191) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" downshifts complement(3875640) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3876220..3876239) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3876234) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" promotor_-35 complement(3876254..3876261) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3876262..3876268 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3876283..3876301 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3876290 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" CDS 3876322..3877392 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" gene 3876322..3877392 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" downshifts 3877390 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" CDS complement(3877449..3877880) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" gene complement(3877449..3877880) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" promotor_-35 3877910..3877917 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3877931..3877950 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3877940..3878106 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3877940 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" promotor_-10 complement(3877992..3878011) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3878012) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" promotor_-35 complement(3878026..3878033) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3878107..3878511 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" gene 3878107..3878511 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" S_feature complement(3878128..3879180) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3878481..3879173 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" gene 3878481..3879173 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" CDS complement(3879213..3880244) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" gene complement(3879213..3880244) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" downshifts complement(3879225) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" promotor_-35 3880211..3880214 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3880227 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3880231..3880250 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3880281..3880299) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3880299) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" promotor_-35 complement(3880314..3880320) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3880337..3881485) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" gene complement(3880337..3881485) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" promotor_-10 complement(3881524..3881543) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3881535) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" promotor_-35 complement(3881554..3881561) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3881607..3881614 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3881628..3881647 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3881635 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" CDS 3881681..3882412 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" gene 3881681..3882412 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" CDS 3882405..3883946 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" gene 3882405..3883946 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" CDS 3883975..3885321 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" gene 3883975..3885321 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" promotor_-35 3884774..3884778 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3884794..3884813 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3884803 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" CDS 3885344..3886750 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" gene 3885344..3886750 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" downshifts 3886739 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" misc_feature 3886847..3886866 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3886849..3887140 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3886849 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" promotor_-35 3887113..3887120 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3887135..3887154 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3887142 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 3887164..3887171 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3887186..3887205 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3887189) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3887192..3887206) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3887201 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" promotor_-35 complement(3887214..3887218) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3887214..3887777 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" gene 3887214..3887777 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" CDS 3887791..3889320 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" gene 3887791..3889320 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" downshifts complement(3889147) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" downshifts 3889313 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" S_feature complement(3889346..3889429) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3889389) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" CDS complement(3889430..3890869) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" gene complement(3889430..3890869) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" CDS complement(3890883..3891113) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" gene complement(3890883..3891113) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" S_feature complement(3891114..3891325) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3891322..3891341) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3891327) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" promotor_-35 complement(3891356..3891363) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3891389..3891396 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3891407..3891426 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3891422 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" CDS 3891457..3892167 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" gene 3891457..3892167 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" CDS 3892195..3892353 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" gene 3892195..3892353 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" downshifts 3892430 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" CDS complement(3892484..3893206) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" gene complement(3892484..3893206) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" downshifts complement(3892496) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" promotor_-35 3893107..3893110 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3893126..3893130 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3893141 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3893227..3893856) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" gene complement(3893227..3893856) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" S_feature complement(3893857..3894005) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3894006..3894764) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" gene complement(3894006..3894764) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" promotor_-10 complement(3894454..3894473) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3894470) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3894486..3894493) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3894745..3895704) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" gene complement(3894745..3895704) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" downshifts 3895693 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" misc_feature 3895740..3895743 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3895748 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3895762..3895911) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" gene complement(3895762..3895911) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" downshifts complement(3895769) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" misc_feature 3895820..3895837 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3895825 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" downshifts 3895906 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" promotor_-10 complement(3895932..3895951) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3895953) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" promotor_-35 complement(3895966..3895973) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3896246..3896253 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3896268..3896287 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3896272 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" CDS 3896383..3898308 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" gene 3896383..3898308 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" S_feature 3898309..3899673 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3898521..3898841) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3898842..3900602) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" gene complement(3898842..3900602) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" downshifts complement(3898885) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" misc_feature 3899670..3899671 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3899675 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3900602..3901000) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" gene complement(3900602..3901000) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" CDS complement(3900993..3902438) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" gene complement(3900993..3902438) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" promotor_-35 3901688..3901695 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3901707..3901726 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3901717..3902766 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3901717 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" S_feature complement(3902439..3902699) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3902700..3903179) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " gene complement(3902700..3903179) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" S_feature complement(3903180..3903259) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3903260..3903430) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" gene complement(3903260..3903430) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" promotor_-10 complement(3903471..3903490) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3903487) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" promotor_-35 complement(3903504..3903509) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3903553..3903560 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3903573..3903592 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3903590 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" CDS 3903615..3904028 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" gene 3903615..3904028 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" downshifts 3904008 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" CDS complement(3904062..3905288) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" gene complement(3904062..3905288) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" downshifts complement(3904077) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" promotor_-10 complement(3905311..3905329) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3905316) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" promotor_-35 complement(3905341..3905349) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3905351..3905521) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" gene complement(3905351..3905521) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" promotor_-10 complement(3905540..3905558) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3905558) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" promotor_-35 complement(3905572..3905578) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3905626..3905874) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" gene complement(3905626..3905874) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" CDS complement(3905890..3907053) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" gene complement(3905890..3907053) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" promotor_-10 complement(3905924..3905942) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3905932) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3905954..3905962) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3907064..3907801) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" gene complement(3907064..3907801) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" promotor_-10 complement(3907843..3907861) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3907849) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" promotor_-35 complement(3907875..3907883) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3907943..3908413) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" gene complement(3907943..3908413) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" downshifts complement(3907956) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" S_feature complement(3908414..3908484) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3908445..3908451 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3908465..3908484 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3908466..3908485) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3908466 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" upshifts complement(3908484) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" S_feature complement(3908486..3908761) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3908500..3908507) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3908524..3909621 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" gene 3908524..3909621 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" promotor_-10 complement(3908752..3908770) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3908761) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" promotor_-35 complement(3908785..3908790) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3909345..3909353 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3909365..3909383 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3909378 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" CDS 3909622..3909738 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" gene 3909622..3909738 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" downshifts 3909727 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" CDS complement(3909975..3910865) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" gene complement(3909975..3910865) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" downshifts complement(3909981) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" downshifts complement(3910043) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" CDS complement(3910939..3912342) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" gene complement(3910939..3912342) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" S_feature complement(3912343..3912564) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3912565..3913770) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" gene complement(3912565..3913770) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" misc_feature complement(3913827..3913845) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3913830) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" promotor_-35 3913940..3913945 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3913960..3913979 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3913975 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" CDS 3914011..3915396 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" gene 3914011..3915396 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" CDS complement(3915378..3915566) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" gene complement(3915378..3915566) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo CDS complement(3915683..3915811) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" gene complement(3915683..3915811) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" downshifts 3915735 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" CDS complement(3915831..3917033) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" gene complement(3915831..3917033) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" downshifts complement(3915855) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3917065..3917076) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3917065) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" promotor_-35 complement(3917091..3917097) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3917115..3917909) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" gene complement(3917115..3917909) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" CDS complement(3917931..3918773) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" gene complement(3917931..3918773) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" CDS complement(3918760..3920127) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" gene complement(3918760..3920127) /gene="walH" /locus_tag="BSU_40390" /old_locus_tag="BSU40390" CDS complement(3920117..3921952) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" gene complement(3920117..3921952) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" CDS complement(3921960..3922667) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" gene complement(3921960..3922667) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" S_feature complement(3922668..3922764) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3922752..3922771) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3922764) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" S_feature complement(3922766..3922958) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3922787..3922790) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3922958) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" misc_feature complement(3922968..3922987) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3923050) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" tRNA complement(3923051..3923123) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3923051..3923123) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" tRNA complement(3923159..3923235) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3923159..3923235) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" S_feature complement(3923236..3923316) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3923317..3923388) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3923317..3923388) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" tRNA complement(3923398..3923473) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" gene complement(3923398..3923473) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" misc_feature 3923445..3923461 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3923458 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3923474..3923570) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3923554..3923573) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3923570) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" promotor_-35 complement(3923587..3923594) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3923604..3923704) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3923644) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" CDS complement(3923697..3924989) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" gene complement(3923697..3924989) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" downshifts complement(3923708) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" promotor_-10 complement(3925029..3925048) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3925049) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" promotor_-35 complement(3925063..3925070) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3925195..3925614) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" gene complement(3925195..3925614) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" promotor_-10 complement(3925612..3925623) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3925623) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" promotor_-35 complement(3925638..3925644) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3925735..3927099) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" gene complement(3925735..3927099) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" downshifts complement(3925755) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" downshifts complement(3925799) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3927130..3927149) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3927144) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" promotor_-35 complement(3927164..3927166) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3927211..3927217 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3927232..3927250 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3927234 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" CDS 3927269..3927469 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" gene 3927269..3927469 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" downshifts 3927439 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" S_feature 3927484..3927805 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3927517..3927720) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" gene complement(3927517..3927720) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" S_feature complement(3927721..3928021) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3927786..3927789 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3927804..3927823 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3927807 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" CDS 3927841..3927981 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" gene 3927841..3927981 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" S_feature 3927982..3928053 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3928029) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" promotor_-10 complement(3928032..3928046) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3928054..3928058) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3928054..3929262 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" gene 3928054..3929262 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" downshifts 3929243 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" CDS 3929367..3931424 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" gene 3929367..3931424 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" downshifts 3931289 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" CDS complement(3931461..3931910) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" gene complement(3931461..3931910) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" downshifts complement(3931475) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" CDS complement(3931907..3933886) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" gene complement(3931907..3933886) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" misc_feature complement(3932388..3932407) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3932391) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" promotor_-35 3932804..3932811 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3932825..3932843 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3932829..3933495 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3932829 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" CDS complement(3933923..3934852) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" gene complement(3933923..3934852) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" S_feature complement(3934853..3934989) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3934971..3934990) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3934989) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" promotor_-35 complement(3935005..3935010) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3935079..3935228) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" gene complement(3935079..3935228) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" downshifts complement(3935105) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3935267..3935286) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3935284) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" promotor_-35 complement(3935300..3935306) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3935307..3935316 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3935329..3935348 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3935335 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" upshifts complement(3935347) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" S_feature complement(3935349..3935862) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3935351..3935365) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3935374..3935378) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3935374..3935856 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" gene 3935374..3935856 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" downshifts 3935843 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" CDS complement(3935886..3936263) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" gene complement(3935886..3936263) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" S_feature 3935888..3936417 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3935907) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" promotor_-10 complement(3936318..3936337) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3936330) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" promotor_-35 complement(3936351..3936358) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3936399..3936403 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3936417..3936436 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3936419 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" promotor_-10 complement(3936444..3936458) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3936447) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3936468..3937397 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" gene 3936468..3937397 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" promotor_-35 complement(3936472) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3937383 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" downshifts complement(3937426) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" CDS complement(3937430..3937876) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" gene complement(3937430..3937876) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" S_feature complement(3937877..3938207) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3938066..3938183) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" gene complement(3938066..3938183) /gene="mswM" /locus_tag="BSU_misc_RNA_94" promotor_-10 complement(3938198..3938217) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3938206) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" promotor_-35 complement(3938231..3938238) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3938244..3938250 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3938263 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" promotor_-10 3938265..3938283 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3938279..3938285 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3938300..3938311 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3938307 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" CDS 3938309..3939616 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" gene 3938309..3939616 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" downshifts complement(3939417) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" downshifts 3939605 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" CDS complement(3939660..3939899) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" gene complement(3939660..3939899) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo downshifts complement(3939681) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" promotor_no_box complement(3939685..3939785) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3939725) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3939889..3940053) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" gene complement(3939889..3940053) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo CDS complement(3940065..3940250) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" gene complement(3940065..3940250) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" downshifts 3940331 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" CDS complement(3940523..3940669) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" gene complement(3940523..3940669) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo CDS complement(3940651..3940800) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" gene complement(3940651..3940800) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo misc_feature complement(3941116..3941132) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3941133) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 3941152..3941159 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3941174..3941377 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3941174..3941193 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3941174 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" misc_feature complement(3941195..3941209) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3941199) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" CDS 3941378..3941815 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" gene 3941378..3941815 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" S_feature 3941816..3941892 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3941849 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" CDS 3941929..3942684 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" gene 3941929..3942684 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" S_feature complement(3942524..3945114) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3942674..3943384 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" gene 3942674..3943384 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" downshifts 3942883 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" CDS 3943381..3944136 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" gene 3943381..3944136 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" CDS 3944133..3944789 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKIKKTTVLDNISYTFEKGTIYGLFGSNGSGKTMLL RALSGLIVPTEGSITIKGEQLHKDISFPKSVGLIIENMQLLPQYDAFTNLKILSKIKK IASDNDILDSISRVGLENFNSVKVSKFSLGMKQRLNIAQAIFEKPDILLLDEPTNAID EKGVAFVHDILLQEKKRGATIIITSHHKEDIISLCDIALEMNHGRLETSEKVIYKKDS *" gene 3944133..3944789 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" S_feature 3944790..3945104 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3945061 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" downshifts 3945105 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" downshifts complement(3945159) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" CDS complement(3945164..3945952) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" gene complement(3945164..3945952) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" promotor_-10 complement(3945976..3945994) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3945995) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" promotor_-35 complement(3946010..3946015) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3946020..3946409) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" gene complement(3946020..3946409) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" promotor_-35 3946478..3946481 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3946496..3946515 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3946509 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" CDS 3946555..3947394 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" gene 3946555..3947394 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" downshifts 3947371 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" CDS complement(3947427..3948641) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" gene complement(3947427..3948641) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" downshifts complement(3947445) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" S_feature complement(3948642..3948745) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3948738..3948757) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3948746..3948753 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3948748) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" promotor_-10 3948767..3948786 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3948771..3948778) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3948779 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" CDS 3948828..3949706 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" gene 3948828..3949706 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" CDS 3949720..3950163 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" gene 3949720..3950163 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" CDS 3950246..3950725 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " gene 3950246..3950725 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" downshifts 3950715 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" CDS complement(3950900..3951562) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" gene complement(3950900..3951562) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" CDS complement(3951709..3952161) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" gene complement(3951709..3952161) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" promotor_-35 3952185..3952192 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3952207..3952226 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3952209 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" S_feature 3952211..3952280 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3952214..3952233) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3952216) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" promotor_-35 complement(3952246..3952253) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3952281..3952727 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" gene 3952281..3952727 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" CDS 3952724..3953329 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" gene 3952724..3953329 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" CDS complement(3953424..3953945) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" gene complement(3953424..3953945) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" S_feature complement(3953946..3954773) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3953994..3954001 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3954015 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 3954016..3954035 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3954081..3954355 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3954081 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" promotor_-35 3954084..3954089 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3954102..3954121 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3954356..3954712 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" gene 3954356..3954712 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" S_feature 3954713..3954871 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3954755..3954774) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3954773) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" promotor_-35 complement(3954789..3954796) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3954872..3955438 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" gene 3954872..3955438 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" CDS complement(3955945..3957321) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" gene complement(3955945..3957321) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" CDS complement(3957355..3957417) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" gene complement(3957355..3957417) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" promotor_-10 complement(3957438..3957457) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3957457) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" promotor_-35 complement(3957470..3957477) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3957605..3957611 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3957627..3957646 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3957633 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" CDS 3957670..3957909 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" gene 3957670..3957909 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" downshifts 3957918 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" promotor_-35 3958002..3958009 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3958025..3958044 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3958041 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" CDS 3958060..3958476 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" gene 3958060..3958476 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" CDS 3958473..3959390 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" gene 3958473..3959390 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" misc_feature 3959417..3959436 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3959427 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" promotor_-10 complement(3959431..3959450) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3959437) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS 3959462..3961531 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" gene 3959462..3961531 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" promotor_-35 complement(3959464..3959471) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3961495 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" CDS complement(3961528..3962427) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" gene complement(3961528..3962427) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" downshifts complement(3961571) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" promotor_-10 complement(3962456..3962475) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3962472) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" S_feature complement(3962474..3963705) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3962490..3962497) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3962568..3962575 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3962589..3962608 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3962595 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" CDS 3962653..3964008 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" gene 3962653..3964008 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" promotor_-10 complement(3963691..3963710) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3963715) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" promotor_-35 complement(3963724..3963733) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3964042..3964596) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" gene complement(3964042..3964596) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" CDS complement(3964614..3964994) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" gene complement(3964614..3964994) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" CDS complement(3965050..3965985) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" gene complement(3965050..3965985) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" promotor_-35 3965975..3965984 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3965998..3966017 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3966005 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-10 complement(3966029..3966048) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3966043) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" CDS complement(3966044..3966802) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" gene complement(3966044..3966802) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" promotor_-35 complement(3966061..3966068) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3966335..3966838 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3966797 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" CDS complement(3966867..3967106) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" gene complement(3966867..3967106) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" downshifts complement(3966873) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" downshifts complement(3966941) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" CDS complement(3967150..3967668) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" gene complement(3967150..3967668) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" CDS complement(3967709..3967996) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" gene complement(3967709..3967996) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" S_feature complement(3967997..3968063) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3968062..3968081) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3968063) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" promotor_-35 complement(3968095..3968100) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3968107..3969207) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" gene complement(3968107..3969207) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" promotor_-10 complement(3969255..3969274) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3969270) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" promotor_-35 complement(3969289..3969296) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3969334..3971337) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" gene complement(3969334..3971337) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" CDS complement(3971388..3971594) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" gene complement(3971388..3971594) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" promotor_-10 complement(3971556..3971575) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3971581) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" promotor_-35 complement(3971590..3971596) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3971620..3971639) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3971631) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" promotor_-35 complement(3971656..3971660) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3971688..3972704) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" gene complement(3971688..3972704) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" promotor_-10 complement(3972737..3972755) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3972749) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" promotor_-35 complement(3972771..3972776) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3972880) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" promotor_-35 3973064..3973069 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3973082..3973163 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3973082 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" promotor_-10 3973085..3973103 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3973164..3973781 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" gene 3973164..3973781 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" promotor_-35 3973752..3973760 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3973771 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" promotor_-10 3973774..3973792 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3973793 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" CDS complement(3973820..3974668) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" gene complement(3973820..3974668) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" downshifts complement(3973840) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" CDS complement(3974661..3975422) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" gene complement(3974661..3975422) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" misc_feature complement(3975456..3975475) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3975474) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" upshifts complement(3975566) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" promotor_-10 complement(3975569..3975577) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3975591..3975599) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3975603..3975611 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3975619 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" promotor_-10 3975623..3975641 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3975670..3976110 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" gene 3975670..3976110 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" downshifts 3976059 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" CDS complement(3976161..3977012) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" gene complement(3976161..3977012) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" downshifts complement(3976180) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" S_feature complement(3977013..3977133) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3977134..3977853) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" gene complement(3977134..3977853) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" CDS complement(3977867..3979753) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" gene complement(3977867..3979753) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" CDS complement(3979774..3981153) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" gene complement(3979774..3981153) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" S_feature complement(3981154..3981284) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3981276..3981295) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3981284) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" promotor_-35 complement(3981311..3981315) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3981339..3981358) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3981349) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" promotor_-35 complement(3981372..3981379) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3981439..3981445 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3981450..3983735 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3981450 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" promotor_-10 3981460..3981479 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3981464..3982090) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" gene complement(3981464..3982090) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" downshifts complement(3981481) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" CDS complement(3982087..3982872) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" gene complement(3982087..3982872) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" promotor_-10 complement(3982917..3982936) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3982929) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3982931..3983016) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3982948..3982954) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3983017..3983367) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" gene complement(3983017..3983367) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" S_feature complement(3983368..3983518) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3983519..3983653) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" gene complement(3983519..3983653) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" promotor_no_box 3983677..3983777 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3983689..3983708) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3983699) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" S_feature complement(3983701..3983769) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3983724..3983731) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3983737..>3983870 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3983737 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" promotor_-10 complement(3983755..3983774) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3983769) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" promotor_-35 complement(3983790..3983794) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" ORIGIN 1 atctttttcg gcttttttta gtatccacag aggttatcga caacattttc acattaccaa 61 cccctgtgga caaggttttt tcaacaggtt gtccgctttg tggataagat tgtgacaacc 121 attgcaagct ctcgtttatt ttggtattat atttgtgttt taactcttga ttactaatcc 181 tacctttcct ctttatccac aaagtgtgga taagttgtgg attgatttca cacagcttgt 241 gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc tatttatcta ctatattata 301 tgttttcaac atttaatgtg tacgaatggt aagcgccatt tgctcttttt ttgtgttcta 361 taacagagaa agacgccatt ttctaagaaa aggagggacg tgccggaaga tggaaaatat 421 attagacctg tggaaccaag cccttgctca aatcgaaaaa aagttgagca aaccgagttt 481 tgagacttgg atgaagtcaa ccaaagccca ctcactgcaa ggcgatacat taacaatcac 541 ggctcccaat gaatttgcca gagactggct ggagtccaga tacttgcatc tgattgcaga 601 tactatatat gaattaaccg gggaagaatt gagcattaag tttgtcattc ctcaaaatca 661 agatgttgag gactttatgc cgaaaccgca agtcaaaaaa gcggtcaaag aagatacatc 721 tgattttcct caaaatatgc tcaatccaaa atatactttt gatacttttg tcatcggatc 781 tggaaaccga tttgcacatg ctgcttccct cgcagtagcg gaagcgcccg cgaaagctta 841 caacccttta tttatctatg ggggcgtcgg cttagggaaa acacacttaa tgcatgcgat 901 cggccattat gtaatagatc ataatccttc tgccaaagtg gtttatctgt cttctgagaa 961 atttacaaac gaattcatca actctatccg agataataaa gccgtcgact tccgcaatcg 1021 ctatcgaaat gttgatgtgc ttttgataga tgatattcaa tttttagcgg ggaaagaaca 1081 aacccaggaa gaatttttcc atacatttaa cacattacac gaagaaagca aacaaatcgt 1141 catttcaagt gaccggccgc caaaggaaat tccgacactt gaagacagat tgcgctcacg 1201 ttttgaatgg ggacttatta cagatatcac accgcctgat ctagaaacga gaattgcaat 1261 tttaagaaaa aaggccaaag cagagggcct cgatattccg aacgaggtta tgctttacat 1321 cgcgaatcaa atcgacagca atattcggga actcgaagga gcattaatca gagttgtcgc 1381 ttattcatct ttaattaata aagatattaa tgctgatctg gccgctgagg cgttgaaaga 1441 tattattcct tcctcaaaac cgaaagtcat tacgataaaa gaaattcaga gggtagtagg 1501 ccagcaattt aatattaaac tcgaggattt caaagcaaaa aaacggacaa agtcagtagc 1561 ttttccgcgt caaatcgcca tgtacttatc aagggaaatg actgattcct ctcttcctaa 1621 aatcggtgaa gagtttggag gacgtgatca tacgaccgtt attcatgcgc atgaaaaaat 1681 ttcaaaactg ctggcagatg atgaacagct tcagcagcat gtaaaagaaa ttaaagaaca 1741 gcttaaatag caggaccggg gatcaatcgg ggaaagtgtg aataactttt cggaagtcat 1801 acacagtctg tccacatgtg gataggctgt gtttcctgtc tttttcacaa cttatccaca 1861 aatccacagg ccctactatt acttctacta ttttttataa atatatatat taatacatta 1921 tccgttagga ggataaaaat gaaattcacg attcaaaaag atcgtcttgt tgaaagtgtc 1981 caagatgtat taaaagcagt ttcatccaga accacgattc ccattctgac tggtattaaa 2041 attgttgcat cagatgatgg agtatccttt acagggagtg actcagatat ttctattgaa 2101 tccttcattc caaaagaaga aggagataaa gaaatcgtca ctattgaaca gcccggaagc 2161 atcgttttac aggctcgctt ttttagtgaa attgtaaaaa aattgccgat ggcaactgta 2221 gaaattgaag tccaaaatca gtatttgacg attatccgtt ctggtaaagc tgaatttaat 2281 ctaaacggac tggatgctga tgaatatccg cacttgccgc agattgaaga gcatcatgcg 2341 attcagatcc caactgattt gttaaaaaat ctaatcagac aaacagtatt tgcagtgtcc 2401 acctcagaaa cacgccctat cttgacaggt gtaaactgga aagtggagca aagtgaatta 2461 ttatgcactg caacggatag ccaccgtctt gcattaagaa aggcgaaact tgatattcca 2521 gaagacagat cttataacgt cgtgattccg ggaaaaagtt taactgaact cagcaagatt 2581 ttagatgaca accaggaact tgtagatatc gtcatcacag aaacccaagt tctgtttaaa 2641 gcgaaaaacg tcttgttctt ctcacggctt ctggacggga attatccaga cacaaccagc 2701 ctgattccgc aagacagcaa aacagaaatc attgtgaaca caaaagaatt ccttcaggcc 2761 attgatcgtg catctctttt agctagagag ggacgcaaca acgttgtaaa actgtccgca 2821 aaaccggctg aatccattga aatttcttcc aattcgccag aaatcggtaa agttgtggaa 2881 gcaattgttg cggatcaaat tgaaggtgag gaattaaata tctcttttag tccaaaatat 2941 atgctggatg cactaaaggt gcttgaagga gcagaaatac gcgtaagctt tacaggcgca 3001 atgagacctt tcttaattcg cacgccgaat gatgaaacga ttgtacagct tatccttcct 3061 gtcagaacct attaatccga tacactgctg ccgacccgtc ggcagctttt ctattcggta 3121 tctgctccga caagttttcc ctttccctaa ttcgtttttt tttagtacaa ttagatatta 3181 gtgatatttg aaagaggtcg atataatggc aaatccgatt tcaattgata cagagatgat 3241 tacactcgga caattcttaa aattagccga tgtgattcag tctggcggta tggcgaagtg 3301 gtttttaagc gagcatgaag tgcttgtgaa cgatgagccg gacaaccgcc ggggcagaaa 3361 gctgtatgtt ggagatgtgg tagagattga aggatttggt tcatttcaag tcgtcaatta 3421 aagcgggtga cactgattgt atatccagaa cttagaactg acatcttacc gcaactacga 3481 ccatgctgaa cttcaatttg aaaataaagt aaatgtgatc atcggagaaa acgcccaggg 3541 gaagacaaac ctcatggagg cgatctatgt cttgtccatg gcgaaatcgc accggacatc 3601 aaatgacaaa gaacttatac ggtgggacaa agactatgct aaaatagagg gaagagtgat 3661 gaagcaaaac ggggcgatcc cgatgcagct cgtcatctcc aaaaagggta aaaagggcaa 3721 ggtcaatcat attgaacagc aaaagctcag ccagtatgtc ggggccctca acaccattat 3781 gttcgcgccg gaagatttaa atcttgtaaa gggaagccct caagtgagaa ggcggtttct 3841 tgacatggaa atcggacagg tttctcccgt ctaccttcat gatctttctc tttaccagaa 3901 aatcctttcc cagcggaatc attttttgaa acagctgcaa acaagaaaac aaactgaccg 3961 gacgatgctc gatgttctga ccgatcagct tgtagaagtt gcagcaaaag tcgtcgtaaa 4021 acgcctgcag tttacagcac agctcgagaa atgggcgcag cccatccatg caggcatctc 4081 aagagggctt gaagaactga ccctgaaata ccatacagct cttgatgtat cagatcccct 4141 agatttgtcg aaaataggag atagctatca agaagcgttt tctaaattaa gagaaaaaga 4201 aattgagcgt ggtgtgacgc tgtcagggcc tcatcgcgat gatgttcttt tctatgtgaa 4261 cggacgcgat gtgcagacgt atggttctca aggacagcag cgaacgacgg cgttgtccct 4321 taagctggcg gagattgacc tgatccatga agaaatcgga gaatatccca ttttactatt 4381 ggatgatgta ctgagtgaac tggatgatta tcgccagtca cacttgcttc atacgatcca 4441 aggccgtgta caaacgtttg tcacaacgac aagcgttgat ggcattgatc acgaaacctt 4501 acgtcaagca ggaatgttcc gtgtgcaaaa tggtgcgtta gtgaagtgaa gaaatgaggt 4561 gagcaattgt atattcattt aggtgatgac tttgtggttt caacacgaga tattgtcggc 4621 atttttgact ttaaagccaa catgtcgcct attgttgaag aatttctgaa aaaacagaaa 4681 cacaaggtgg tgccttccgt aaacggcacg cccaaatcta tcgtagtcac ggttcagaat 4741 atatattact ctcccttatc ttccagcaca ttaaaaaaac gtgcgcaatt tatgtttgaa 4801 atagattctt agaaattttt tatcacgaat atatcgttta gaaaagtgta ggtgaatgac 4861 gtggctatgg aacagcagca aaacagttat gatgaaaatc agatacaggt actagaagga 4921 ttggaagctg ttcgtaaaag accggggatg tatatcggtt cgacaaacag caaaggcctt 4981 caccacttgg tatgggaaat tgtcgacaat agtattgacg aagccctcgc cggttattgt 5041 acggatatca atatccaaat cgaaaaagac aacagtatca cggttgtaga taatggccgc 5101 ggtattccag tcggtattca tgaaaaaatg ggccgtcctg cggtagaagt cattatgacg 5161 gtgcttcatg ccggaggaaa atttgacgga agcggctata aagtatccgg aggattacac 5221 ggtgtaggtg cgtcggtcgt aaacgcacta tcaacagagc ttgatgtgac ggttcaccgt 5281 gacggtaaaa ttcaccgcca aacctataaa cgcggagttc cggttacaga ccttgaaatc 5341 attggcgaaa cggatcatac aggaacgacg acacattttg tcccggaccc tgaaattttc 5401 tcagaaacaa ccgagtatga ttacgatctg cttgccaacc gcgtgcgtga attagccttt 5461 ttaacaaagg gcgtaaacat cacgattgaa gataaacgtg aaggacaaga gcgcaaaaat 5521 gaataccatt acgaaggcgg aattaaaagt tatgtagagt atttaaaccg ctctaaagag 5581 gttgtccatg aagagccgat ttacattgaa ggcgaaaagg acggcattac ggttgaagtg 5641 gctttgcaat acaatgacag ctacacaagc aacatttact cgtttacaaa caacattaac 5701 acgtacgaag gcggtaccca tgaagctggc ttcaaaacgg gcctgactcg tgttatcaac 5761 gattacgcca gaaaaaaagg gcttattaaa gaaaatgatc caaacctaag cggagatgac 5821 gtaagggaag ggctgacagc gattatttca atcaaacacc ctgatccgca gtttgagggc 5881 caaacaaaaa caaagctggg caactcagaa gcacggacga tcaccgatac gttattttct 5941 acggcgatgg aaacatttat gctggaaaat ccagatgcag ccaaaaaaat tgtcgataaa 6001 ggtttaatgg cggcaagagc aagaatggct gcgaaaaaag cgcgtgaact aacacgccgt 6061 aagagtgctt tggaaatttc aaacctgccc ggtaagttag cggactgctc ttcaaaagat 6121 ccgagcatct ccgagttata tatcgtagag ggtgactctg ccggaggatc tgctaaacaa 6181 ggacgcgaca gacatttcca agccattttg ccgcttagag gtaaaatcct aaacgttgaa 6241 aaggccagac tggataaaat cctttctaac aacgaagttc gctctatgat cacagcgctc 6301 ggcacaggta tcggagaaga cttcaacctt gagaaagccc gttaccacaa agttgtcatt 6361 atgacagatg ccgatgttga cggcgcgcac atcagaacac tgctgttaac gttcttttac 6421 agatatatgc gccaaattat cgaaaatggc tacgtgtaca ttgcgcagcc gccgctctac 6481 aaggttcaac aggggaaacg cgttgaatat gcatacaatg acaaggagct tgaagagctg 6541 ttaaaaactc ttcctcaaac gcctaagcct ggactgcagc gttacaaagg tcttggtgaa 6601 atgaatgcca cccagctatg ggagacaacc atggatccta gctccagaac acttcttcag 6661 gtaactcttg aagatgcaat ggatgcggat gagacttttg aaatgcttat gggcgacaag 6721 gtagaaccgc gccgaaactt catagaagcg aatgcgagat acgttaaaaa tcttgacatc 6781 taatcataaa aagccttatt tccaataaga aataaggctt ttttctgaac aagatcagat 6841 gcagcgatgc ctgcaatacc tatatattct agcaatttaa tgtgtataat cataagttta 6901 ttgatataat ggagaatagt gaaatcgtat tgaaggtcat aatggacaat ctactcccac 6961 atatttcatg tgatacttca gggaggtttt ttaatgagtg aacaaaacac accacaagtt 7021 cgtgaaataa atatcagtca ggaaatgcgt acgtccttct tggattatgc aatgagcgtt 7081 atcgtgtccc gtgctcttcc ggatgttcgt gacggtttaa aaccggttca tagacggatt 7141 ttgtatgcaa tgaatgattt aggcatgaca agtgacaagc cttataaaaa atccgcgcgt 7201 atcgttggag aagttatcgg gaaataccac ccgcacggtg attcagcggt atatgaatcc 7261 atggtcagaa tggctcagga tttcaactac cgttatatgc tcgttgacgg tcacggaaac 7321 ttcggttctg ttgacggaga ctcagcggcg gccatgcgtt atacagaagc acgaatgtct 7381 aaaatctcaa tggagattct tcgcgacatc acaaaagaca caatcgatta ccaggataac 7441 tatgacgggt cagaaagaga acctgtcgtt atgccttcaa ggttcccgaa tctgctcgtg 7501 aacggtgctg ccggcattgc ggtaggtatg gcaacaaaca ttcctccgca ccagctggga 7561 gaaatcattg acggtgtact tgctgttagt gagaatccgg acattacaat tccagagctt 7621 atggaagtca ttccagggcc tgatttcccg accgcgggtc aaatcttggg acgcagcggt 7681 atccggaaag catacgaatc aggccgaggc tctatcacga tccgggcaaa agctgagatc 7741 gaacaaacat cttcgggtaa agaaagaatt atcgttacag agttacctta ccaagtaaat 7801 aaggcgaaat taattgagaa aattgctgat ctcgtaaggg acaaaaagat agagggtatc 7861 acagatctgc gtgatgagtc agatcgtaca ggtatgagaa ttgtcattga aatcagacgc 7921 gatgccaatg cgaatgttat cttaaacaat ctgtacaaac aaactgctct acaaacatct 7981 tttggcatca acctgcttgc gcttgttgat ggccagccga aagttttaac tcttaagcaa 8041 tgcctggagc attaccttga ccatcaaaaa gttgtcatta gacgccgtac tgcttatgaa 8101 ttgcgtaaag cagaagcgag agctcatatc ttggaaggat tgagagttgc actggatcat 8161 ctcgatgcag ttatctccct tatccgtaat tctcaaacgg ctgaaattgc gagaacaggt 8221 ttaattgaac aattctcact gacagagaag caagcacaag cgatccttga catgaggctc 8281 cagcgtttaa cgggactgga acgtgaaaag atcgaagaag aataccagtc tcttgttaaa 8341 ttaattgcag agctaaaaga catcttggca aatgaatata aagtgcttga gatcattcgt 8401 gaagaactca cggaaatcaa agagcgtttt aacgatgaaa gacgtactga gatcgtcact 8461 tctggactgg agacaattga agatgaagat ctcatcgaga gagaaaatat cgtagttact 8521 ctgacgcaca acggatacgt caaacgtctt cctgcatcaa cttaccgcag tcaaaaacgg 8581 ggcggaaaag gtgtacaagg tatgggaaca aacgaagatg atttcgttga acatttgatc 8641 tctacgtcaa ctcatgacac gattctcttc ttctcgaaca aggggaaagt gtatcgtgca 8701 aaagggtatg aaatccctga atacggcaga acggcaaaag gaatcccgat tattaacctg 8761 ctggaggtag aaaagggtga gtggatcaac gcgattattc cagtcacgga attcaatgcg 8821 gagctttacc tcttcttcac tacaaagcat ggggtttcaa aacgaacatc gctatctcaa 8881 ttcgctaata tccgcaacaa tggtctaatt gctctgagtc ttcgtgaaga tgatgaactg 8941 atgggtgtac gtctgactga cggcacaaaa caaatcatca ttggaacgaa aaacggttta 9001 ctgattcgtt tccctgaaac agatgtccga gagatgggaa gaactgcggc gggcgtaaaa 9061 ggcatcaccc tgacggatga cgacgttgtt gtcggcatgg agattttaga ggaagaatca 9121 cacgtcctta tcgtaactga aaaagggtac ggaaaacgaa ctcctgctga agagtacaga 9181 acccaaagcc ggggcggaaa aggactcaaa acagcgaaaa tcaccgagaa caacggccaa 9241 ctagtagcag tgaaagctac taaaggtgaa gaggatctaa tgattattac agctagcggc 9301 gtactcatca gaatggacat caatgatatc tccatcaccg gacgtgtcac tcaaggtgtg 9361 cgtctcatca gaatggcaga agaagagcat gttgctacag tagctttagt tgagaaaaac 9421 gaagaagatg agaatgaaga agaacaagaa gaagtgtgaa aaaaagcgca gctgaaatag 9481 ctgcgctttt ttgtgtcata accctttaca gtcataaaaa ttatggtata atcatttctg 9541 ttgtcttttt aaagacacaa gcatgaccat tatgactagt aaaaactttt tcaaaaaagt 9601 attgacctag ttaactaaaa atgttactat taagtagtcg ctttgagaga agcacacaaa 9661 gttctttgaa aactaaacaa gacaaaacgt acctgttaat tcatttttat aaatcgcaca 9721 gcgatgtgcg tagtcagtca aactagggcc tgcacgacgc aggtcacaca ggtgtcgccg 9781 caggatgcgg tgaacttaac ctgtgatcca tttatcggag agtttgatcc tggctcagga 9841 cgaacgctgg cggcgtgcct aatacatgca agtcgagcgg acagatggga gcttgctccc 9901 tgatgttagc ggcggacggg tgagtaacac gtgggtaacc tgcctgtaag actgggataa 9961 ctccgggaaa ccggggctaa taccggatgg ttgtttgaac cgcatggttc aaacataaaa 10021 ggtggcttcg gctaccactt acagatggac ccgcggcgca ttagctagtt ggtgaggtaa 10081 cggctcacca aggcgacgat gcgtagccga cctgagaggg tgatcggcca cactgggact 10141 gagacacggc ccagactcct acgggaggca gcagtaggga atcttccgca atggacgaaa 10201 gtctgacgga gcaacgccgc gtgagtgatg aaggttttcg gatcgtaaag ctctgttgtt 10261 agggaagaac aagtgccgtt cgaatagggc ggtaccttga cggtacctaa ccagaaagcc 10321 acggctaact acgtgccagc agccgcggta atacgtaggt ggcaagcgtt gtccggaatt 10381 attgggcgta aagggctcgc aggcggtttc ttaagtctga tgtgaaagcc cccggctcaa 10441 ccggggaggg tcattggaaa ctggggaact tgagtgcaga agaggagagt ggaattccac 10501 gtgtagcggt gaaatgcgta gagatgtgga ggaacaccag tggcgaaggc gactctctgg 10561 tctgtaactg acgctgagga gcgaaagcgt ggggagcgaa caggattaga taccctggta 10621 gtccacgccg taaacgatga gtgctaagtg ttagggggtt tccgcccctt agtgctgcag 10681 ctaacgcatt aagcactccg cctggggagt acggtcgcaa gactgaaact caaaggaatt 10741 gacgggggcc cgcacaagcg gtggagcatg tggtttaatt cgaagcaacg cgaagaacct 10801 taccaggtct tgacatcctc tgacaatcct agagatagga cgtccccttc gggggcagag 10861 tgacaggtgg tgcatggttg tcgtcagctc gtgtcgtgag atgttgggtt aagtcccgca 10921 acgagcgcaa cccttgatct tagttgccag cattcagttg ggcactctaa ggtgactgcc 10981 ggtgacaaac cggaggaagg tggggatgac gtcaaatcat catgcccctt atgacctggg 11041 ctacacacgt gctacaatgg acagaacaaa gggcagcgaa accgcgaggt taagccaatc 11101 ccacaaatct gttctcagtt cggatcgcag tctgcaactc gactgcgtga agctggaatc 11161 gctagtaatc gcggatcagc atgccgcggt gaatacgttc ccgggccttg tacacaccgc 11221 ccgtcacacc acgagagttt gtaacacccg aagtcggtga ggtaaccttt taggagccag 11281 ccgccgaagg tgggacagat gattggggtg aagtcgtaac aaggtagccg tatcggaagg 11341 tgcggctgga tcacctcctt tctaaggata ttttacggaa tataagacct tgggtcttat 11401 aaacagaacg ttccctgtct tgtttagttt tgaaggaact ttgttccttg aataagttaa 11461 gatgggcctg tagctcagct ggttagagcg cacgcctgat aagcgtgagg tcggtggttc 11521 gagtccactc aggcccacca tcttatataa cggggcctta gctcagctgg gagagcgcct 11581 gctttgcacg caggaggtca gcggttcgat cccgctaggc tccaccaacg tgttctttga 11641 aaactagata acagtagaca tcacattcaa ttagtaacac aagatatcac atagtgattc 11701 tttttaacgg ttaagttaga aagggcgcac ggtggatgcc ttggcactag gagccgatga 11761 aggacgggac gaacaccgat atgcttcggg gagctgtaag caagctttga tccggagatt 11821 tccgaatggg gaaacccacc actcgtaatg gagtggtatc catatctgaa ttcataggat 11881 atgagaaggc agacccgggg aactgaaaca tctaagtacc cggaggaaga gaaagcaaat 11941 gcgattccct gagtagcggc gagcgaaacg ggatcagccc aaaccaagag gcttgcctct 12001 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 12061 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 12121 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 12181 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 12241 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 12301 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 12361 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 12421 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 12481 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 12541 ccaatcgaac ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 12601 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 12661 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 12721 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 12781 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 12841 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 12901 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 12961 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 13021 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 13081 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 13141 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 13201 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 13261 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 13321 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 13381 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 13441 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 13501 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 13561 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 13621 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 13681 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 13741 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 13801 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 13861 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 13921 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtgtca ggtgggcagt 13981 ttgactgggg cggtcgcctc ctaaaaggta acggaggcgc ccaaaggttc cctcagaatg 14041 gttggaaatc attcgcagag tgtaaaggca caagggagct tgactgcgag acctacaagt 14101 cgagcaggga cgaaagtcgg gcttagtgat ccggtggttc cgcatggaag ggccatcgct 14161 caacggataa aagctacccc ggggataaca ggcttatctc ccccaagagt ccacatcgac 14221 ggggaggttt ggcacctcga tgtcggctca tcgcatcctg gggctgtagt cggtcccaag 14281 ggttgggctg ttcgcccatt aaagcggtac gcgagctggg ttcagaacgt cgtgagacag 14341 ttcggtccct atccgtcgcg ggcgcaggaa atttgagagg agctgtcctt agtacgagag 14401 gaccgggatg gacgcaccgc tggtgtacca gttgttctgc caagggcatc gctgggtagc 14461 tatgtgcgga cgggataagt gctgaaagca tctaagcatg aagcccccct caagatgaga 14521 tttcccattc cgcaaggaag taagatccct gaaagatgat caggttgata ggtctgaggt 14581 ggaagtgtgg cgacacatgg agctgacaga tactaatcga tcgaggactt aaccatattt 14641 ttgaatgatg tcacacctgt tatctagttt tgagagaaca ctctcaattt gtttggtggc 14701 gatagcgaag aggtcacacc cgttcccata ccgaacacgg aagttaagct cttcagcgcc 14761 gatggtagtc gggggtttcc ccctgtgaga gtaggacgcc gccaagcaag cttaaaccca 14821 gctcaatgag ctgggttttt tgtttgttaa aaatgaagaa gaaactgtga agcgtattta 14881 gggaatttct tttctgatac taataaaaac tgctgaatta acacgtagtc atcacttata 14941 tgctgtgtta ataactcata ccaccattct gtttcatacc ttgcaatcat cccaacgttg 15001 tacaaaatca aataatgaat tgtcatttcg ggaagcctca gaaattgctc cctttgagaa 15061 gggatataat attggttctt ttccatgtca aacaataagc tggtcgatgt ccatggctcc 15121 ttgtcttgtg gtgaaatttc gaacagcagc ccgtgttcat ttttttttgt aaaagaccat 15181 tgataatgat gggacatgta ttcagcaaac cttgaatcag acattttgta attgattact 15241 acttcctccg gtacaaaaat ttcgttctta tccttctcaa cttttgtcat aaatcgttct 15301 ttctgctgaa agtagaaaat atcgctaagt tctggaatgg ccattaataa ttttttcatg 15361 gtataccgtt catctactat atccgattgt ccgaataaat gtttcataaa atgtacgcat 15421 aggccattcc gttgtatttt cacttcatcg tcgctaaaac aataattttg tttctttcgt 15481 tttcttgttg ttacgccatg tgccagtact gatgtatggc ttggataatg aggatcacgt 15541 gtaattaagc atgctttgat aagctgtgcc attccataaa ataaaagaat cggtttgatt 15601 tctaagggag aatatgcggc ttgtttataa aacgattcgg catgctttaa gaaataaata 15661 aaccgttcac tgtttttaaa agagtttttt ttcgcatcgt taataccgtt taagatataa 15721 accttttcta gaaatttctg ggttgattca acggagtaaa atagcgctaa gtctttccac 15781 tcatgatatg tcatgtatat ttcttaatcc tttccgttat ctaaatattt caactctttc 15841 ccgcttcctt gacatgctct tggctagttg ataatctaca tataatattt tgccgaaaag 15901 agggggattt actaatgtgg gaaagtaaat tttcaaaaga aggcttaacg ttcgacgatg 15961 tgctgcttgt accagcaaag tctgaggtac ttccgcgtga tgtggattta tctgtagaac 16021 ttacaaaaac gttaaagcta aatattcctg tcatcagcgc aggtatggac actgtaacag 16081 aatcagcaat ggcaattgca atggcaagac agggcggctt gggcatcatt cacaaaaata 16141 tgtccattga acagcaggct gaacaagttg ataaagtaaa gcgttctgag cgcggcgtta 16201 tcacaaatcc cttcttttta actcctgatc accaagtatt tgatgcggag catttgatgg 16261 ggaaatacag aatttccggt gttccgattg taaataacga agaagaccag aagcttgttg 16321 gaattattac aaaccgtgac cttcgtttta tttctgacta ctcaatgaaa atcagcgacg 16381 tcatgacgaa agaagagcta gttactgcat ctgtaggaac tactctggat gaagctgaaa 16441 agattttgca gaaacataaa attgaaaagc ttcctctcgt agatgaccag aataaattaa 16501 aaggtcttat cacaattaaa gacattgaaa aagtcattga gttcccgaac tcatctaaag 16561 acattcacgg ccgcctgatc gttggcgcgg cagttggtgt aactggcgat acaatgactc 16621 gcgtcaaaaa gcttgttgaa gccaatgttg atgtgattgt tatcgataca gctcacggac 16681 actctcaagg cgttttaaac acagtcacaa aaatccgtga aacgtatccc gaattaaaca 16741 ttattgctgg aaacgtggca acagctgaag cgacaagagc gcttatcgaa gctggagcag 16801 acgttgtcaa agttggaata gggcctggtt caatttgtac tacacgtgtt gtagccggcg 16861 tgggtgttcc gcaaattaca gcaatttatg attgtgcgac tgaagcaaga aaacacggca 16921 aaacaatcat cgccgacggt gggattaaat tctctggcga tatcactaaa gcattggcag 16981 ccggcggaca tgctgttatg ctcggaagct tgcttgcagg cacatcagaa agccctggtg 17041 aaactgaaat ctaccaaggc agaagattta aggtataccg cggcatggga tcagttgctg 17101 caatggaaaa aggaagtaaa gaccgttact tccaagaaga aaacaaaaaa tttgttcctg 17161 aaggaattga aggacgcaca ccttacaaag ggccagttga agaaaccgtt tatcagctag 17221 tcggaggcct tcgttctggt atggggtatt gcgggtccaa agatctgcgt gcgctaagag 17281 aagaagctca gttcattcgc atgactggcg caggacttcg cgaaagccat ccgcatgacg 17341 tacagattac aaaagaatca cctaactata caatttcata ataaattgtt acaaattaaa 17401 aacatttgac agggtctctg actctgtcta ttttttttat actgattatg ataaaattta 17461 tactgttgtg cattgaaaat gtccttaacg gcttaattat agatgaagaa aatgaaatac 17521 ggaggtcgta cgattgaaca tcaagaaatg taaacagcta ctgatgtcat tggttgtgtt 17581 aactctagct gtcacgtgtc tggctccaat gtcaaaagcg aaagcagcca gcgatccaat 17641 tgatatcaat gcatctgctg ctattatgat cgaagcttct tcaggtaaaa ttctttacag 17701 taaaaatgca gataagagac tgccaattgc gagtatgaca aaaatgatga cagagtatct 17761 gttattggaa gcaattgatc aaggtaaagt gaaatgggac caaacctata cgcctgatga 17821 ctatgtgtat gaaatttccc aagataacag cttatcaaac gttcctcttc ggaaagacgg 17881 gaaatacaca gtaaaagaat tatatcaagc tacagcaatt tattctgcaa atgctgctgc 17941 tattgcgatt gcagaaatcg ttgccggttc tgaaactaag tttgttgaaa aaatgaatgc 18001 aaaagcaaaa gaactaggct taacagatta caaatttgtt aacgcaacag gtcttgaaaa 18061 caaagatctt cacgggcatc agcctgaggg gacaagcgta aatgaagaaa gtgaagtttc 18121 tgcaaaggat atggcggttc ttgcggatca cttgattact gactaccctg agatactgga 18181 gacttccagt atcgccaaaa cgaaattcag agaaggcacc gatgatgaaa tggacatgcc 18241 gaactggaat tttatgctga aggggcttgt cagcgagtat aaaaaagcga ctgtagacgg 18301 actgaaaaca ggttctactg actctgcggg ttcatgcttt acaggaacag ctgaacgcaa 18361 cggtatgcgt gtcatcactg ttgttttaaa cgcaaagggc aaccttcata caggccgttt 18421 cgatgaaacg aaaaaaatgt ttgattatgc tttcgacaat ttctccatga aagaaattta 18481 tgctgaaggc gatcaagtaa aaggccataa aacaatttca gttgataagg gtaaagagaa 18541 agaagtaggc attgtgacaa acaaggcgtt ctctcttcct gtcaaaaatg gtgaagaaaa 18601 gaattacaaa gcgaaggtca cactgaataa agacaactta actgctcctg tgaaaaaagg 18661 aaccaaggtt gggaagctga ctgcggaata cacaggtgat gaaaaggatt acggattcct 18721 taacagcgat ctggctggcg tagaccttgt tacaaaagaa aatgtagaaa aagcaaactg 18781 gtttgttttg acaatgcgca gtatcggcgg attttttgcc ggaatttggg gaagcattgt 18841 tgatacggta accggctggt tttaatcaat tgaaagagct ctgatggatg ttagggctct 18901 ttcgcgtaat atactgaaaa aacccaattt ttaataaaaa atgattttca aagcgctaaa 18961 aaccgaataa aatagtatat atgcatatga attattggat ttctaggata caataaggat 19021 tagaaatcat ataactatac cttgattagg gggaccaaga aatggctcaa acaggtactg 19081 aacgtgtaaa acgcggaatg gcagaaatgc aaaaaggcgg cgtcatcatg gacgtcatca 19141 atgcggaaca agcgaaaatc gctgaagaag ctggagctgt cgctgtaatg gcgctagaac 19201 gtgtgccagc agatattcgc gcggctggag gagttgcccg tatggctgac cctacaatcg 19261 tggaagaagt aatgaatgca gtatctatcc cggtaatggc aaaagcgcgt atcggacata 19321 ttgttgaagc gcgtgtgctt gaagctatgg gtgttgacta tattgatgaa agtgaagttc 19381 tgacgccggc tgacgaagaa tttcatttaa ataaaaatga atacacagtt ccttttgtct 19441 gtggctgccg tgatcttggt gaagcaacac gccgtattgc ggaaggtgct tctatgcttc 19501 gcacaaaagg tgagcctgga acaggtaata ttgttgaggc tgttcgccat atgcgtaaag 19561 ttaacgctca agtgcgcaaa gtagttgcga tgagtgagga tgagctaatg acagaagcga 19621 aaaacctagg tgctccttac gagcttcttc ttcaaattaa aaaagacggc aagcttcctg 19681 tcgttaactt tgccgctggc ggcgtagcaa ctccagctga tgctgctctc atgatgcagc 19741 ttggtgctga cggagtattt gttggttctg gtatttttaa atcagacaac cctgctaaat 19801 ttgcgaaagc aattgtggaa gcaacaactc actttactga ttacaaatta atcgctgagt 19861 tgtcaaaaga gcttggtact gcaatgaaag ggattgaaat ctcaaactta cttccagaac 19921 agcgtatgca agaacgcggc tggtaagaac ataggagcgc tgctgacatg ttaacaatag 19981 gtgtactagg acttcaagga gcagttagag agcacatcca tgcgattgaa gcatgcggcg 20041 cggctggtct tgtcgtaaaa cgtccggagc agctgaacga agttgacggg ttgattttgc 20101 cgggcggtga gagcacgacg atgcgccgtt tgatcgatac gtatcaattc atggagccgc 20161 ttcgtgaatt cgctgctcag ggcaaaccga tgtttggaac atgtgccgga ttaattatat 20221 tagcaaaaga aattgccggt tcagataatc ctcatttagg tcttctgaat gtggttgtag 20281 aacgtaattc atttggccgg caggttgaca gctttgaagc tgatttaaca attaaaggct 20341 tggacgagcc ttttactggg gtattcatcc gtgctccgca tattttagaa gctggtgaaa 20401 atgttgaagt tctatcggag cataatggtc gtattgtagc cgcgaaacag gggcaattcc 20461 ttggctgctc attccatccg gagctgacag aagatcaccg agtgacgcag ctgtttgttg 20521 aaatggttga ggaatataag caaaaggcac ttgtataaaa cagttgaaag ctgtggaaac 20581 ttatagtaca ttataagcac aaataaagat cgaaaagcgt tgataggaac tagtagggag 20641 cctctctttc taagagagcc gatggttggt gcgaatcggt gaaagatgct gtctgaatcc 20701 atccttgagc gaaatgctga agcgagtagg catttacggg ataaccgtta tgtttgaaag 20761 tggaaaacga gtctttgatt tgttttcaat cagggtggca acgcgagagc tctcgtccct 20821 ttatggggat gagggctctt tttattttcg ataaatcaat aaaaaaagga gtgtttcgca 20881 tgcttgatac gaaaatgctg agagcaaatt ttcaagaaat taaagcaaag cttgtacaca 20941 aaggcgaaga cttaactgat tttgataagt ttgaggcgct ggatgataga cgaagagagc 21001 ttatcggcaa ggttgaagag ttaaaaggaa aacgaaatga agtttctcag caggttgctg 21061 tgctgaagcg tgagaaaaaa gacgcggatc acattattaa agaaatgcgt gaagtcggcg 21121 aggaaattaa aaagctcgat gaagaattac ggacagtgga agctgagctt gatacaatcc 21181 tgctctcaat cccgaatatt ccgcatgagt ctgtacctgt cggtgaaaca gaagacgaca 21241 acgtagaagt gcgtaaatgg ggtgaaaagc cttcatttgc ttatgagccg aagccgcact 21301 gggatattgc ggatgagctg ggtattctgg attttgaacg tgctgccaaa gtaacaggaa 21361 gccgtttcgt gttctataaa ggcttaggtg ctcgtctgga gcgtgcgctt tataacttta 21421 tgcttgatct gcatgtggat gagtataact acactgaagt gatcccgcca tatatggtaa 21481 accgcgcaag catgacggga acggggcagc ttcctaaatt tgaagaggat gcatttaaaa 21541 tcagagaaga agattatttc ttaattccaa cggcggaagt gccgattaca aacatgcatc 21601 gcgatgaaat cctttcaggt gacagcctgc cgatcaacta tgcggcattc agtgcttgct 21661 tccgttctga agctggttca gcaggacgtg acacacgcgg attaattcgt cagcaccaat 21721 ttaataaagt tgagcttgta aagtttgtga agcctgaaga ttcttatgaa gaattagaga 21781 aacttacaaa ccaagcagaa cgggttcttc agctgcttga gcttccatac cgtgtcatga 21841 gcatgtgtac gggtgactta ggctttacgg ctgcgaaaaa atacgatatc gaagtttgga 21901 ttccaagcca agacacatat cgagaaatct cttcttgcag caacttcgaa gcgttccagg 21961 cgagacgtgc gaatattcgt ttcagacgtg aagcgaaagg caagcctgag catgtacaca 22021 cactgaacgg ctcaggactg gcggttggaa gaacagttgc tgctatctta gaaaattatc 22081 agcaggaaga cggaagcgtt gtgattccga aagtgcttcg tccttatatg gggaatagag 22141 aagtaatgaa accgtaaatt atggaaaggc gtgcctgaca aggtgcgcct ttttgcttat 22201 gtaaacacgg cattttcata aaaacaaaaa aagtttttaa aaatgcttga ccacacgaga 22261 acatacgtga tatagttagt cttgtcgata cggaggaata cccaagtccg gctgaaggga 22321 tcggtcttga aaaccgacag gggtgtcaaa gcccgcgggg gttcgaatcc ctcttcctcc 22381 gccatattga ttttaattct aatgaaacac aagcatatat tggagattgt tttgtccgtt 22441 gcattcggtg cggcggattt tttattttaa agaaaaagtg aatctcgact gagattcact 22501 ttttttgatt atcatgaata actgaagcaa tttgatctac aatattttca atcgagtttt 22561 cgtcgttcag aagatcataa tcttcaatgc gaagttttaa aacagggcag gcattaaaac 22621 cgcttatcca gttctcgtag cgtgtatgca tttcttccca ataagaccgg cttgtctgaa 22681 gctccatctc acggccgcgt tgttcaatcc ggtttaaaat gttctccaga tctccttcta 22741 aatagatcaa cacatctgga tgtgggaaat acggtgtcat taccattgct tcgaaaaggc 22801 ttgtgtaagt cttataatca acctttgaca ttgtcccttt atcagcatgc atttttgcga 22861 aaattcctgt atcttcataa atcgaacgat cctgtacaaa acctccgccg gcttcaaaaa 22921 ttgttttctg ttctttgaag cgttcagcta agaagtaaat ttgaaggtga aagctccaac 22981 gttcaaaatc atgatagaac ttttccaaat atggattatg atcgacttcc tccaacgatg 23041 ttttaaatcc aagccgttta gctaaagttt ttgttaaagt cgattttccg acacctactg 23101 ttcctgctac tgtaataatt gaattcttag ggatatgatg ttccttcata cgataagctc 23161 ctttacatgg gcggcaatgc gttcaaagtc gctcttattc aaaacgaaat cctttgaatc 23221 accatctacg gttaacactg taagttcagg gtctgcttcc tgcagctgct tgatggcgac 23281 ttcataatct gaaatcagct gctccaaata gctagtttca atttttttct caaaggggcg 23341 cccgcgtttt tcaatgcggt gtagcaatgt aggcagactg gcctttatgt aaatgatgaa 23401 attcggcttt ggcagatcat ccgttagcag gtgatatatc tttttgtatt tttccagctg 23461 atgtggagac aaggttcgtt ccgcaaaaat cacattttta taaatatgat aatcagctat 23521 tacaggctgt ccctttttta aaaagtgatc actggtgtct tcaagctgtt tgtatctgtg 23581 acaaagaaaa aacatctcga gctggaagct ccattccttt atattgtcat aaaacttatc 23641 aaggtacggg ttatcctcta caatctcatt gatcataggg aatccgaatt tttgtgagag 23701 catcgttgcg agagttgttt ttcctgcccc gataggacct tctattgcaa taaaaggggc 23761 tgtattcatc ggaatcctcc ttatatctga aaaacgtgcg tcagttaccg accttcatat 23821 tgtatcacaa cccttgggtg cccccatgaa aaaaagacgt ttccaaatta tcgaaacgtc 23881 tttttgacaa cattaaattg atcagacagc agcagccagt tttgtggaaa ggaaagaccc 23941 agcttccaat agctgatgcc tcttaaattc agctctttaa tcagattgaa ttttgcttga 24001 atcgagcggg catcctcgaa ccatacctcg tgccttctgt tttctgcatc agtatagcgg 24061 aagaaaggag cttgagcggt ttggtcatac tgaatggaag cattgttctg atcagctatg 24121 acaatggctt gctgagggct tactgctctt gctggagttc cccctgctgt atatggcagc 24181 gtccagtcat atccatataa attctggccc atgacaattt tgttcgcagg catttcagtc 24241 aaagcatatt ctatgacatc acggacaggt ccaattggag aaaccgcttg aggcggtccg 24301 ccgctatagc cccattcata tgtcatgaga acaacaaagt cgacaatttc gccatgtgcc 24361 ctgtaatcat gagcttcata ccacctgccc tgctgtgttg cacttgtttt aggagcaaga 24421 gccgtagaaa tttctaagcc ctctcgatgg aaaagatccc ttgcttcgcg gaggaattga 24481 ttataggcct ctctatcctg gggccgcaaa tattcaaagt cgaaatgaat gtcacggaag 24541 ccatatcttc tggcattctc gactatttca tttagaagcc gtctttttac agtttcgtcg 24601 ttcaaaagga tccggccaag ttcatcgctg aatgcctggt tttctaggtt cgttataatc 24661 atcatcaatg ttgtattttg actttctgta atgctcctta aattcgttaa aggcggtgcg 24721 actaaggttc cgttccgctg tgcctggaag ctgaatgcgc caaggtaagt taagtagggc 24781 gacgcttctc tggccgcctg ctggagattt tcgctgactt gatttcctcg gggctccaaa 24841 taagcatttg attcgatgtc tcgtttagga gctggaggga tgtataaacg gaaaccaatc 24901 tgaagcacgg tatttaactg gatgcggtta acccttgcga gctcggctgc tgttgtattg 24961 aactgccggg cgatggatgt cagggtatca cctcgcttca catcatagaa ctggccagct 25021 attggaatga caatggtttg tccgacaaca aggctgtcgg gattcggtat ttcattcgtt 25081 tcagtgatgt catttgtggt tgttctgtat tgtgaagcga tagcagaaag agtgtcgcct 25141 tgttttacca cataaatttg aatgaaaaac gcctcctttc atatcgctat caatgtatga 25201 aagaaaagcg ctgatcatgt ttatttttct ataatttgtt cttccgtcgt aatttctgcg 25261 aaaagaacat tctccatcat ggttaaggcg aattcgttat cttcgtcact gtttgacgcg 25321 atacagtcct taggaatcgt gatgctgtat tccctcatat aagcgtcatt agcggtaaac 25381 agcacgcata tattgccggc tatacctgtt atgataatat gtctcacctg caactcagta 25441 agaagggtgt gaagtgctgt ttcgtagaaa gcggaatgtt tcggtttgat taaaaaataa 25501 tcagcatcta ccggagctat ctttgtgatg atatccttgc ttctttcatt tgtgcattct 25561 tgctgtatgt ttttaatgtc agcttgccaa agtccataat gatcattgat gtaaataatc 25621 ggccattcat tttgtctcgc gtgctccttt aatgataaaa tatgaggaac gattttttct 25681 gtttttttag cgagggtttc ccccatatcg aattcaaaat tattgatcat gtctacaatg 25741 agaagggctt tatctgcttt ggacaatcga cagtctcctt tccgtttcag ttatagttaa 25801 tatgtagcct ttttaggcaa tgaaaaaact ttgaaaagag agcttatcct tatgacacaa 25861 gatgaacttt atatgaaaga agcaattaaa gaagcgaaaa aggctgaaga gaaaggtgaa 25921 gtgccaatag gtgcggtgct tgtcattaat ggtgaaatta tagcgcgtgc gcataattta 25981 agagagactg aacagcgatc tattgcccat gcagaaatgc ttgtaattga tgaagcgtgt 26041 aaggcactcg gaacatggcg gctggaaggt gcgactcttt atgtgacgct tgagccttgt 26101 ccaatgtgtg ctggtgcagt cgtactttct cgagtggaaa aagtggtttt tggcgcattt 26161 gatccgaaag gcggctgttc aggcacgcta atgaaccttc ttcaggagga acgctttaat 26221 catcaggctg aagtggtgag cggtgtgctt gaggaagaat gcggcggaat gctcagtgcg 26281 tttttcagag aactaagaaa aaagaagaaa gccgccagga aaaacttgtc tgaatagtac 26341 ggttgcaatt tttaggggaa acagatatac ttaagtgtgc atcgtaatag atgcaacata 26401 aaatttgata tttattttgc cgtgctaagc ggggaggtag cggtgccctg tacctgcaat 26461 ccgctctagc agggccgaat cccttctcga ggttcgttta ctttaaggcc tgccttaagt 26521 aagtggtgtt gacgtttggg tcctgcgcaa tgggaattca tgaaccatgt caggtccgga 26581 aggaagcagc attaagtgaa acctctcatg tgccgcaggg ttgcctgggc cgagctaact 26641 gcttaagtaa cgcttagggt agcgaatcga cagaaggtgc acggtaaatc aatcatcaaa 26701 ttttcagact cacctaatat taggtgagtt ttttgttatg taaaaagagc ttttggaatc 26761 gaaacaaggt tcatgtataa tgggaatgat gaataacgga ggagggcaaa cccgtgagtt 26821 accaagcttt atatcgagta ttcaggcctc agcgctttga agatgtggtc ggacaagaac 26881 acattacaaa aacgctgcaa aatgcccttt tgcaaaaaaa gttttctcac gcctatctgt 26941 tttccgggcc tagaggaacc ggaaaaacca gtgcagccaa aatatttgct aaggctgtca 27001 actgtgaaca tgctcctgtt gatgagccat gcaacgaatg tgcggcctgt aaagggataa 27061 caaacgggtc aatatccgat gtcatagaaa ttgacgccgc ttctaataac ggtgttgatg 27121 agattcgtga cattcgcgat aaagtgaagt ttgccccatc ggccgtcaca tataaggtat 27181 atatcataga tgaggtgcat atgctttcta tcggcgcttt taatgcatta ctaaaaacat 27241 tagaagagcc gcctgagcat tgtattttca tattagcaac aactgaaccg cacaaaattc 27301 ctttaaccat tatctctaga tgtcagcgtt ttgactttaa acgaattacc tcccaagcga 27361 ttgtaggccg catgaataaa attgttgatg ctgaacagct gcaagtggag gaaggatcgc 27421 tggaaatcat cgcgagtgct gcagacggag ggatgaggga tgccctgagc cttcttgatc 27481 aggccatatc attcagcggc gatatcctga aagtcgaaga tgcgctttta attacgggtg 27541 ctgtttctca attatatatc gggaagcttg caaaatccct gcatgataaa aacgtttctg 27601 acgcactgga aacattaaat gaattgcttc agcaaggaaa agatccagct aagctgatag 27661 aagatatgat tttctatttc agggacatgc tgctgtacaa aacagcccct ggcttagagg 27721 gagtgcttga gaaagtaaaa gtcgatgaaa cgttccggga actaagtgaa caaattccgg 27781 ctcaggccct atatgaaatg attgatattc tgaacaagag ccatcaggaa atgaaatgga 27841 caaatcatcc gcgtatcttt ttcgaagtgg ccgttgtgaa gatttgccaa acctcacatc 27901 aatctgctgc tgatctcccg gaagtggata tgctgatgaa aaaaatccag cagctcgaac 27961 aggaagtaga gcggctcaaa acaacgggca taaaagcagc tgcggaaagc ccgaaaaaag 28021 aagcgccgcg tgtgccaaag ggcgggaaat ccaattacaa agcgccagta ggcagaattc 28081 atgagatttt gaaggaagcc acaagaccgg atcttgatct gctcagaaac agttggggca 28141 agcttcttgc tcatctcaaa cagcaaaaca aagtatcaca tgccgctttg ctgaatgaca 28201 gtgaacctgt ggctgccgga tcggcggcat ttgttctgaa attcaaatat gaaattcatt 28261 gtaaaatggt cgctgaggat aacaacggag tccggactaa tcttgagcag attttagaat 28321 cgatgctcgg aaaaagaatg gatttgattg gcgttccaga agcacaatgg ggtaaaataa 28381 gagaagaatt tttagaagat catcagcagg aaaatgaagg atcaaatgaa ccggctgaag 28441 aagacccgct tattgccgaa gcgaaaaagc ttgttggagc ggatttaatt gaaataaaag 28501 actaacaaaa tgaaagagag tgaatgctat gcgtggcgga atgggtaata tgcaaaaaat 28561 gatgaaacaa atgcaaaaaa tgcaaaagga catggcgaag gctcaagaag agcttgcaga 28621 aaaggttgtt gaaggaactg caggcggcgg tatggtaaca gtaaaagcaa acggccaaaa 28681 agaaatcctg gatgttatca tcaaagaaga agtcgttgat cctgaagata ttgatatgct 28741 tcaagattta gtgcttgctg caacgaatga agctttgaaa aaagttgacg aaatcacaaa 28801 cgaaacaatg ggtcaattta caaagggaat gaacatgcca ggtttattct agggggataa 28861 aagaacatgc aatatcctga accaatatca aagctgattg acagctttat gaaattgcca 28921 gggatcggac cgaaaacagc ggttcgtctg gctttttttg ttctaggtat gaaagaagat 28981 gtagtattag attttgcgaa agcattagta aatgcgaaac gcaacctgac atattgttca 29041 gtttgcgggc atattacaga tcaggaccct tgctatatat gtgaagatac gcgcagggat 29101 aagtctgtta tctgtgttgt gcaagaccct aaagacgtta tcgctatgga gaaaatgaag 29161 gaatacaacg gacagtatca cgttcttcac ggcgctattt ctccaatgga cggcatcgga 29221 ccggaggata ttaaaatacc agaattgtta aaacgattac aggatgatca agtgacagaa 29281 gtgatcctcg cgacaaaccc taatatagaa ggggaagcaa cagcgatgta tatatcaagg 29341 ctcctcaagc cgtctggtat taagctctcc cgtattgccc acggactgcc cgtcggcggt 29401 gatttggaat atgctgatga ggtcactctt tctaaagcac ttgaaggaag acgtgaattg 29461 taaggaggaa aaagcgatcc atgggttttc ttcgcaagaa aacattaaga agagagtttg 29521 atgaaaaact aaccgagcag ctttttaagc aaaaggaaga gtggaacagg caaaaaaagc 29581 tggttgaaaa aagcttagaa ccgtctgctg aagtgttata cgaactgaaa gtagctgaag 29641 cgaagtattt tttttactta agggaagcga agcagcgaaa tttaaaaatc agccggtgga 29701 agtaagtggt ctaaactcct ggatcttctc ataagcttgt actagaacaa gcgaaggaga 29761 tgagaagatt catggagcct atttttatta ttgggattat tttaggactg gttattcttc 29821 tttttttatc aggttcagca gcgaagcctt taaagtggat tggcatcaca gctgttaaat 29881 ttgtggcagg tgctttgctg ctggtttgtg taaatatgtt tggcggcagt cttggcattc 29941 atgtgccgat taatctggtt acaacagcta tcagcggaat tttaggaata cccggaatag 30001 ctgcgttagt cgtcattaag caatttatca tttaattgat attatgtatt gacttagaca 30061 actgaaggtg ttattctaat atacgtcgct gatgacgaac agcttttttg aaaagaaaat 30121 gctaaaaagt tgttgacagt agcggcggta aatgttatga taataaagtc gcttaaacga 30181 gcggtaaaca aagttctttg aaaactaaac aagacaaaac gtacctgtta attcattttt 30241 ataaatcgca cagcaatgtg cgtagtcagt caaactactt tatcggagag tttgatcctg 30301 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 30361 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 30421 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 30481 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 30541 tgaggtaacg gctcaccaag gcgacgatgc gtagccgacc tgagagggtg atcggccaca 30601 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 30661 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 30721 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 30781 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 30841 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 30901 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 30961 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 31021 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 31081 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 31141 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 31201 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 31261 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 31321 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 31381 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 31441 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 31501 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 31561 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 31621 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 31681 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 31741 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 31801 tcggaaggtg cggctggatc acctcctttc taaggatatt ttacggaata taagaccttg 31861 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggaacttt gttccttgaa 31921 taagttaaga tgggcctgta gctcagctgg ttagagcgca cgcctgataa gcgtgaggtc 31981 ggtggttcga gtccactcag gcccaccatc ttatataacg gggccttagc tcagctggga 32041 gagcgcctgc tttgcacgca ggaggtcagc ggttcgatcc cgctaggctc caccaacgtg 32101 ttctttgaaa actagataac agtagacatc acattcaatt agtaacacaa gatatcacat 32161 agtgattctt tttaacggtt aagttagaaa gggcgcacgg tggatgcctt ggcactagga 32221 gccgatgaag gacgggacga acaccgatat gcttcgggga gctgtaagca agctttgatc 32281 cggagatttc cgaatgggga aacccaccac tcgtaatgga gtggtatcca tatctgaatt 32341 cataggatat gagaaggcag acccggggaa ctgaaacatc taagtacccg gaggaagaga 32401 aagcaaatgc gattccctga gtagcggcga gcgaaacggg attagcccaa accaagaggc 32461 ttgcctcttg gggttgtagg acactctgta cggagttaca aaggaacgag gtagatgaag 32521 aggtctggaa aggcccgcca taggaggtaa cagccctgta gtcaaaactt cgttctctcc 32581 tgagtggatc ctgagtacgg cggaacacgt gaaattccgt cggaatccgg gaggaccatc 32641 tcccaaggct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga 32701 aaagcacccc ggaaggggag tgaaagagat cctgaaaccg tgtgcctaca agtagtcaga 32761 gcccgttaac gggtgatggc gtgccttttg tagaatgaac cggcgagtta cgatcccgtg 32821 caaggttaag cagaagatgc ggagccgcag cgaaagcgag tctgaatagg gcgcatgagt 32881 acgtggtcgt agacccgaaa ccaggtgatc tacccatgtc cagggtgaag ttcaggtaac 32941 actgaatgga ggcccgaacc cacgcacgtt gaaaagtgcg gggatgaggt gtgggtaggg 33001 gtgaaatgcc aatcgaacct ggagatagct ggttctctcc gaaatagctt tagggctagc 33061 ctcaaggtaa gagtcttgga ggtagagcac tgattggact aggggcccct accgggttac 33121 cgaattcagt caaactccga atgccaatga cttatccttg ggagtcagac tgcgagtgat 33181 aagatccgta gtcgaaaggg aaacagccca gaccgccagc taaggtccca aagtatacgt 33241 taagtggaaa aggatgtgga gttgcttaga caaccaggat gttggcttag aagcagccac 33301 catttaaaga gtgcgtaata gctcactggt cgagtgactc tgcgccgaaa atgtaccggg 33361 gctaaacgta tcaccgaagc tgcggactgt tcttcgaaca gtggtaggag agcgttctaa 33421 gggctgtgaa gccagaccgg aaggactggt ggagcgctta gaagtgagaa tgccggtatg 33481 agtagcgaaa gaggggtgag aatcccctcc accgaatgcc taaggtttcc tgaggaaggc 33541 tcgtccgctc agggttagtc gggacctaag ccgaggccga aaggcgtagg cgatggacaa 33601 caggttgata ttcctgtacc acctcctcac catttgagca atggggggac gcaggaggat 33661 agggtaagcg cggtattgga tatccgcgtc caagcagtta ggctgggaaa taggcaaatc 33721 cgtttcccat aaggctgagc tgtgatggcg agcgaaatat agtagcgaag ttcctgattc 33781 cacactgcca agaaaagcct ctagcgaggt gagaggtgcc cgtaccgcaa accgacacag 33841 gtaggcgagg agagaatcct aaggtgatcg agagaactct cgttaaggaa ctcggcaaaa 33901 tgaccccgta acttcgggag aaggggtgct ctgttagggt gcaagcccga gagagccgca 33961 gtgaataggc ccaggcgact gtttagcaaa aacacaggtc tctgcgaagc cgtaaggcga 34021 agtatagggg ctgacgcctg cccggtgctg gaaggttaag aggagcgctt agcgtaagcg 34081 aaggtgcgaa ttgaagcccc agtaaacggc ggccgtaact ataacggtcc taaggtagcg 34141 aaattccttg tcgggtaagt tccgacccgc acgaaaggcg caacgatctg ggcactgtct 34201 caacgagaga ctcggtgaaa ttatagtacc tgtgaagatg caggttaccc gcgacaggac 34261 ggaaagaccc cgtggagctt tactgcagcc tgatattgaa tgttggtaca gcttgtacag 34321 gataggtagg agccttggaa accggagcgc cagcttcggt ggaggcatcg gtgggatact 34381 accctggctg tattgacctt ctaacccgcc gcccttatcg ggcggggaga cagtgtcagg 34441 tgggcagttt gactggggcg gtcgcctcct aaaaggtaac ggaggcgccc aaaggttccc 34501 tcagaatggt tggaaatcat tcgcagagtg taaaggcaca agggagcttg actgcgagac 34561 ctacaagtcg agcagggacg aaagtcgggc ttagtgatcc ggtggttccg catggaaggg 34621 ccatcgctca acggataaaa gctaccccgg ggataacagg cttatctccc ccaagagtcc 34681 acatcgacgg ggaggtttgg cacctcgatg tcggctcatc gcatcctggg gctgtagtca 34741 gtcccaaggg ttgggctgtt cgcccattaa agcggtacgc gagctgggtt cagaacgtcg 34801 tgagacagtt cggtccctat ccgtcgcggg cgcaggaaat ttgagaggag ctgtccttag 34861 tacgagagga ccgggatgga cgcaccgctg gtgtaccagt tgttctgcca agggcatcgc 34921 tgggtagcta tgtgcggacg ggataagtgc tgaaagcatc taagcatgaa gcccccctca 34981 agatgagatt tcccattccg caaggaagta agatccctga aagatgatca ggttgatagg 35041 tctgaggtgg aagtgtggcg acacatggag ctgacagata ctaatcgatc gaggacttaa 35101 ccacattttg aatgatgtca cacctgttat ctagttttga gagaacacct ctctaaaggc 35161 ggaaggtaag gaaactccgc taagggctct cacatcctgt gagaaacgcc cagtaccttc 35221 atcctgaagg catttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 35281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 35341 acgccgccaa gcaagcttaa acccagctta atgagctggg ttttttgttt actcaagatc 35401 gagaaaatca aacaaataca aacaccgagg gcttatatag cccatatact gatttaaagt 35461 ttcaaaaagg tctaaatagt gtatacaata tccgttttaa ggggaggcta actgtacgga 35521 ggtggagaag atggacgaaa cagttaaact taatcataca tgtgtgattt gtgatcaaga 35581 gaagaataga ggcattcatc tttatacgaa attcatatgc ttagattgtg agagaaaagt 35641 aatttctaca tcaacttctg atcctgacta tgcgttttac gtaaaaaaac taaagagcat 35701 tcatacaccg ccattatatt catagacctg aaaaggtctt tttttgtact cttaataata 35761 aaaagaagat gaaacttgtt taaggattga acgtagtaga taataatatt aaaactgagt 35821 atagacacag gagtcgatta tctcatgcag agattttttc actttttggt gtggagttta 35881 actagcagtg cgacttttgt tttcattgga atattgagct tttttggttt aaaccagtcg 35941 atttttttat ctattgttta tgggcttgct tctggagcag ccgtatatat agctggcatc 36001 tggaatgcaa gacggttatt tcttaaaaag catgaattga caggaagaga gtatgcttac 36061 attaagaaaa acttagagga agcaaggcag aaaatggtcc gtcttaggaa agccttgttt 36121 caggctaaaa gcattcaaat gtttaagcaa aatgcagaaa tgctaaggat tgtgagaagg 36181 atttatctcc tcaccaaaaa agagccaaag cggttttatc aggcagaacg atttttttat 36241 caaactctcg attcggttgt tgaattgaca gagaagtatg cttttctatc atctcaccca 36301 aaaaaaagca aagaactgtc gatgtcgtta agtgagacac gcatcactct tactgaattg 36361 accaagcgtt tagaggaaga tttaactcaa gcaatgggtg atgaaattga cgagttgcag 36421 tttgaattag acgcagcaaa acattcatta aagaaataag ggaagagggt aagagcgatg 36481 aaccgagacc aaagcgacct tcatatagat gaattattgg cagatccttt tggtggtaac 36541 atagagatac caggttcgga ggctgtaaaa gcagagaaag agcaagtacg gcttgttgat 36601 gttcttcctg aggaaaacaa ggaaaaagca attcagcttg ctggacagat tgatcataaa 36661 aatatgcaaa gcattgtctt atacggttca caagctcaat ctaaactgct gaacttttct 36721 catgatatga ttaatcatgt tcaaaagaag gatgtcgggg agattggcga aatacttgga 36781 gagctgatga aaaagctgga gcaagtaaat cctgatgatc tccaatctaa gaaaaagggt 36841 tttttggcac gcatgtttgg aagagtatca agttctcttc aagaggtgct gtctaaatac 36901 caaaagacca gtgtgcagat agacagaatc agcttgaagc tggagcactc taaaaatgct 36961 ttaatcagtg acaacaagct gttagagcag ttatatgaaa aaaataaaga atatttcgca 37021 gcgctgaatg tttatattgc tgcaggagaa ctgaagctgg aggaattaaa aacaaaaacg 37081 attcctgaac tgaagcaaca ggctgaatcg agtgatcata accaaatggc cgttcaagag 37141 gtgaatgatt taattcaatt tgctgaccgg ttagataaaa gggtgcatga tttgctgctg 37201 agcaggcaaa ttacaatcca aagtgcaccg caaatcaggc tgattcaaaa tacaaaccaa 37261 gcgttagctg aaaagattca gtcatccatt gtgacagcga ttccgttatg gaaaaatcaa 37321 gttgccattg cactgacgct tttaaggcag cgcaatgcag tggatgcaca gcagaaagta 37381 tctgatacaa ccaatgagct tttgctgaaa aatgcggagc ttttaaaaac caatacaatt 37441 gaaactgcac gggcaaatga aagaggcctt gttgatatag ataccttgaa gaaggtgcag 37501 gaaagcttaa taagcacgct tgaagaaaca ctgactatac aagaagaagg acgaatcaaa 37561 cgccgtcagg cagaagaaga gctcatgatg atggaaggcg acctgaagca aaagctgatt 37621 acaataaagg aaagatgatt accagtaagt ctggctttaa gttctgtcag aggcacgata 37681 taataaggtg taagaagaca cattcaaagg attgttttca tgaacacacc tttatataaa 37741 gcattaattc aacatgcgag aagaaattct cattcatttc atgttccggg acatcacaat 37801 ggagatgtct tttttgatga cgctaagtca atattcgatc cgcttctcac cattgatgta 37861 actgaactgg caggactgga tgatctccat catccttctg gggtgattaa ggaagctcag 37921 gagcttgcca gtcaattata tggatcggcg gaaagttttt ttctggtaaa tggtacgact 37981 gtcggaaact tagcgatgat tttatctgtt tgtgaacctg gtgatacaat tctggttcaa 38041 agaaactgtc ataaatctgt atttcatgct gttgatttgt ccggtgctga gccggtttat 38101 cttgcacctg acgttgattc agcgatgcat gtgcctacgc atgttccgct tggaacaatt 38161 aaagaggccc tggaagcata tccagatgcg aaaggcttgg tactgaccaa tccgacatat 38221 tacggacata gtgctgattt gactgagatc attactgaag cccatcatta cgggattcct 38281 gttttggtcg atgaagcgca tggcgcacat tttattttag gtgagccttt tccggtctca 38341 gctttaaaaa tgggggcaga tattgttgtt cagtcggccc acaaaacgtt gccagccatg 38401 acgatgggtt cttatttgca tctcaacagc agctgcagga ttaacaggga tcgggtggca 38461 gagtatttaa accgattaca aagcagcagc ccgtcttatc cgattatggc ttcgttagat 38521 attgcccgcg cttatgtaca gcatattata gaagaacaaa agctttctga cattctgcag 38581 cggatagaaa cacttaaaca aacgtttgat tcacttacaa atgcagaagc tgttaaccct 38641 gctaatccac tgatcatcac ggatccgcta aagctcacaa ttcgttcaaa acgcgggcat 38701 tctggctata cgctgcaaag cattttagag cgtgccaaca tattcactga gcttgctgat 38761 gaaaatcaag ttctgctcgt tctcccattg ggaggaaaac ggagaataaa cgctgaaatc 38821 attagaagca tcgatgaaga gattgagaaa acgcctccgg atcagacgtt tgtttctgca 38881 gaatggggtg tgcagcctgt tactgtcttg ccttatccaa aaaaggtctt acattcgttt 38941 aagaaagaat atgtgagctt tgaggaagca gctggccggc ttaatgcaga agatatcatc 39001 ccttatcctc cgggtatccc gatgattatg gcgggagaaa gaataacaaa agaaagtgtg 39061 caaaagctca gccgcttgat cagcatgaaa acgcatgttc aagggaatat gaaaatcaaa 39121 gagaaacaac tacttgttta tatagaagag gagaaatcat gagcggttta tttattacat 39181 tcgaaggtcc tgaaggtgca gggaaaacga ctgttctgca ggagatcaaa aacatactga 39241 cagcagaagg ccttcaggtt atggcaactc gagagccagg cggaatagat attgcagaac 39301 aaattagaga ggttattctg aatgagaaca atatattaat ggacccaaaa acagaagctc 39361 tcttatatgc ggctgcaaga cgccagcatt tagttgaaaa agtaaaacct gctttagaac 39421 aggggtttat cgttctttgc gacagattca tagacagttc tcttgcgtat caaggatatg 39481 caagagggct tggaattgat gaggttctgt ccattaatga atttgccatt ggagatatga 39541 tgccccatgt aacggtttat ttttcaattg atccggaaga aggactgaag cgtatttacg 39601 caaacggctc acgggagaaa aacaggctcg atttagaaaa actggacttt catacaaaag 39661 tacaagaagg ttatcaagag ctgatgaagc gatttccgga aagatttcat tcagttgatg 39721 ccgggcaatc caaagacctc gtcgttcagg atgttctaaa ggtgatcgat gaagcgttga 39781 aaaaaattca attgtgacct gtttcccaat agttgatata ataatgtaaa cgagatcacg 39841 ttgtttccaa tctaaaggag gccttcacag atgaaattga tagtggcagt tgtacaagat 39901 caggacagca acagactttt gaaaacctta acggatcaca acttcagagt cacaaagctt 39961 gcaacgacag gaggatttct taaatcaggc aatacaacgt ttatgatcgg tgtcgaggat 40021 atacgcgtca ataaagcgtt gagtctcatt aaagaaaacg ggcagaaacg tgatcagatg 40081 attgcccctg tatctccaat gggtggaaat gctgattcct atgtccctta tccagtcgaa 40141 gttgaagttg gcggagcgac agtatttgtc cttccagtcg atgaatttca tcaattttaa 40201 ggatctgaaa ctgtgaaaat taataaagat atacgtacat ttatagataa taagcagatt 40261 ccctctgtga aaacatctga gatcacagca tcgtttaaaa catcaatgga aaaccaaagc 40321 agcaaaatga agcttgatca gcttaccagg ctgttatctg atatagaagc atttggaaaa 40381 aggctaacga aatctcggaa ttttaaagac ttagcgagat ttaaaggact tgtgaaacgt 40441 tttgtcaaag aagctgtgga cagcggtctt tcacatgaaa catcgaaaag ctttgacctt 40501 tacgggaaca gcagaacgct gggacttgtg aaagaaatag atgacaaatt gatacagctt 40561 acggaagaga tgatggatca ggaaaaaccg gcaattgatt tgctggagcg tattggcgaa 40621 ataaaaggtt tattaattaa cctttacaca tagagagtga tacaatggca atatcctgga 40681 aggaaatgaa cgagcttcag cccagagtga tgaagctttt atataatagt attgagaagg 40741 acagactatc acacgcttat ttgtttgagg ggaaaaaagg aacaggcaag cttgatgccg 40801 cgctgcttct tgcaaaaagc ttcttttgtc tggagggtgg cgcggagcct tgtgagagct 40861 gccgaaactg taaacggata gagtcaggga accatcctga tctccatctt gttcagcctg 40921 atggcttatc aatcaaaaag gcgcaaattc aagcgctcca agaagagttt tctaagacag 40981 gacttgaatc gcataaaaag ctgtatatta tttcgcacgc agatcaaatg acagcaaatg 41041 cggcgaacag cctgctgaaa tttttagaag aaccgaacaa agacacaatg gccgtcctca 41101 tcactgagca gccccaaagg ttattggata ccatcatttc aagatgccaa acccttcctt 41161 ttcagccttt gcagccgaaa gcaattgaag acagactgat cgaacaggac gtctcgcctc 41221 atatggcaag gcttctggcc aacatgacta ataatgtagc agaagcagtc gaattaagtc 41281 gaaatgatga gtttgcagag tctagagcga aagtgataaa attgtatgaa gtcctacacc 41341 agcggaaagg acatgctttt ttctttattc aagatcaatg gatgcccttt ttcaaagaaa 41401 aaacccatca agaaatgggt cttgatatgc tcttattgat atatcgtgat gtgttgtcca 41461 tccaaatagg aaatgaagat aaattgattt atcaagactt attccaatca ataaaacagc 41521 atgcgctaca atcaacacaa caaagcgtta cgaatcagat acttgctgtt ttagaagcaa 41581 agaaacggct tcattccaat gtgaatgtac aaggattaat ggagcacttg gtgttaatgt 41641 tgcaggaggg ataagcttgt acaatgtaat tggtgtccgc tttaagaaag cgggtaaaat 41701 atattatttt gatccgaatg gatttcatat agaacatgac agctgcgtaa ttgtagaaac 41761 tgtcagaggc gttgagtacg gccaggtcgt aattgcaaat aaacaggtgg atgagcatga 41821 tgtggtgctt ccccttcgaa aagtgatacg tgtggcagac gatcgcgatc ttctcattgt 41881 agaagaaaat aaacaggaag cactatcagc atttgatatc tgccaaaaga aagtgattga 41941 gcatggcttg gatatgaagc tggtcgatgt tgaattcacg tttgatcgca ataaagtcat 42001 tttttacttc actgctgacg gccgagtcga ctttagagag cttgtaaagg atttggcttc 42061 tatctttaag acaagaattg agctgcgcca aatcggagtg agggatgagg caaaaatgct 42121 cggaggaatc ggtccttgcg gaagaatgct ttgctgttca acgtttcttg gagattttga 42181 acccgtttcc attaaaatgg ccaaggatca gaacttgtct ttaaatccta cgaagatttc 42241 gggtctttgc ggacgattga tgtgctgtct aaaatatgag aacgatgagt atgagacggc 42301 aaaagaacag cttccggata taggagaaat gattacgaca gcaaacggtc ccgcgaaggt 42361 cgtcggacta aatattctgg aacgggtgct tcaggtggaa ctgataaacc gtgaaaaagt 42421 gatagaatat acttgggaag agctcttgga agagggcgtc gtatccgcac aaaccacaga 42481 ttaacgaggt gtggaacctt ggataaaaaa gagttatttg atacagtcat taacttagaa 42541 gaacaaattg gctcactgta ccggcagctg ggggatttga agcagcatat cggtgagatg 42601 attgaggaaa atcatcattt acagcttgaa aacaagcatt tgcgcaaacg gctggacgat 42661 acgacgcagc agattgaaaa gttcaaagct gataaaaaag aatcaaaaac acagaagaca 42721 gagcaaactg atatagggga aggatatgat aatctggcac gtctgtatca agaaggattt 42781 catatctgca atgtccacta tggaagtgtt cgaaaagagg attgtctttt ctgtctgtca 42841 ttcttaaata aaaaataggg aaaaggcttc cgcataagac gggagccttt ttcaaaggta 42901 ctgaaaggat aagaagatgg tttcattaca tgatgatgaa agattagatt atttgctggc 42961 agaggacatg aaaatcatac aaagcccaac agtgtttgct ttttcgttgg acgctgtgct 43021 tctgtccaaa tttgcgtacg ttccgattca aaaagggaaa attgttgatt tatgcaccgg 43081 caatggtatt gtgccgctgc tgctcagtac aagatcaaaa gcagacattc tgggagtcga 43141 aattcaagaa agactgcatg atatggctgt tcgcagcgtg gagtataata agttggacga 43201 tcagatccag atcatacatg atgacctgaa aaacatgccg gagaaacttg gacataatcg 43261 atatgatgtt gtcacctgca atccgccgta ttttaaaacg ccgaaacaaa ctgaacaaaa 43321 catgaacgag catctccgaa tcgcaagaca tgaaatccac tgcacgctgg aggatgtcat 43381 ttcagtcagc agcaagctgc tcaagcaagg gggaaaagca gctcttgttc accggccggg 43441 aaggcttctg gagatttttg aactgatgaa ggcttatcaa atcgagccga aacgtgtaca 43501 atttgtctat ccgaagcaag ggaaagaagc caataccatt ttggttgaag gtatcaaagg 43561 cgggcgcccg gatttgaaaa ttcttcctcc cttattcgta tatgatgaac aaaatgaata 43621 tacaaaagaa atcaggacca ttttatatgg agacaaataa ccatttcttc tacgtcgtga 43681 aatgtaagga caatagctgg tatgccgggt ataccaacga tctgcataaa cgagtgaaaa 43741 cgcacaatga tggaaagggc gcaaagtaca caaaagtaag acgtccggtt gaattaattt 43801 ttgccgagag cttttcaaca aagcgggaag ctatgcaggc ggaatattat ttcaaaaaac 43861 taactcggaa gaaaaaagag ctttatatag aagaaaagcg gaacagcaag gaggctgtat 43921 atgttaaggc gccaaatgag ctttaatgga aagtcggaca tggggattct ttacttggtc 43981 ccaaccccaa tcggaaattt agaggatatg acattccggg cgatcgacac gctgaaatca 44041 gtggatgcga ttgctgcgga agatacgagg caaacgaaaa agctttgtca tgtatatgaa 44101 attgaaacac cgctcgtcag ctatcacgaa cacaataaag aaagcagtgg gcacaaaatt 44161 attgaatggc tgaaatcggg aaaaaacatt gctcttgtca gtgatgccgg tctgccgacg 44221 atttctgatc ccggagcgga aattgtaaag gattttacgg atataggcgg ttatgttgtt 44281 ccgttgccgg gagcaaatgc tgcattaaca gctcttattg cttcaggtat tgtaccgcag 44341 ccttttttct tttacggttt tctcaacaga cagaaaaaag aaaagaagaa ggagcttgaa 44401 gcccttaaaa aacggcagga aacgatcatt ttttatgaag cgccccacag attgaaggaa 44461 accttgtcag cgatggcaga gatattagga gatcgggaaa ttgctgtaac acgtgaactc 44521 actaagaaat atgaagagtt tatccgagga accatatctg aggtcattgg atgggcaaac 44581 gaggatcaga tacgcggcga gttttgtctt gtcgtagaag gaagtaataa tgaagaggta 44641 gatgaggaag aacaatggtg ggaaaccctc actgcgaaag aacatgtcga gcattacatt 44701 tcgaaaggcg ctacgtctaa agaagctatt aaaaaagcag cagtcgatcg caatgtacca 44761 aagcgtgaag tgtacgatgc ttaccatatt aagcaataaa aaaacgttct tgtgtcataa 44821 caagaacgtt ttttgtacaa gaaatgatta tttaaggttt tgaagctggt tttggatttc 44881 gctgatgatt tgctcagcgc cttctttact aagaaccaat ttaccgcctg caagtttaag 44941 gttatcatca gaaacttcac cagttacttg gcaagtcatg tttggtttat attttttaag 45001 gatgattttt tcatcatcaa catagatttc aagagcatct ttttctgcga ttccaagagt 45061 acgacgcagt tcgataggaa taactacacg tcctaattca tcaactttac gtacaatacc 45121 agtagatttc ataaacattc tcctcccaag agatacttat ttgtttaaat tatatttttc 45181 ttcgtcatta ttcgacaaaa tccttacctt catagcataa caaggtttcc aataatcgtc 45241 aatcattttg tttactattg attgtaagaa ttagttctta tagtcagtaa tgtcttggaa 45301 actaccgaaa taacagcatt ttataaatat ttaataaagc tattatccta ctaaaaatcc 45361 ttttaaatca agactttcga accaaagttt tttatttcat ttgattatat acgacaaaat 45421 tcgacacgaa cagacttttt ttattttcat taaagatttt taattttaat tattcttttt 45481 cagggcgtat gtatatattc ttgatcttaa aggctaagat ggtatcatag ataaaggata 45541 aatataaata atattcatat atgatttgca cttatcgccg ctctcgtcct ttgggcggga 45601 gctttttgac attctgatta ggaggtttca agatgccgca agaaaacaat acattttaca 45661 ttacaacacc gatttattat ccgagcggaa aattacatat cggccatgca tatacgacag 45721 tcgcaggaga tgcaatggca cgttacaaaa gattaaaagg gttcgatgtt cgctatttaa 45781 cgggaacgga cgagcatgga caaaagatcc agcaaaaagc tgaacaggaa aacattacac 45841 ctcaggagta tgtggatcgc gcagcggcag atattcaaaa actgtggaag cagcttgaaa 45901 tctcaaacga cgactttatc cgcacgacag aaaaacggca taaagttgtc attgaaaaag 45961 tgtttcaaaa gcttcttgat aacggggaca tctatcttga tgagtatgaa ggctggtaca 46021 gcatccctga tgaaacgttc tacacggaaa ctcagctcgt tgatattgag cggaatgaaa 46081 agggagaggt catcggcgga aaaagccctg acagcggtca cccagttgaa ttgatcaaag 46141 aggaatctta tttcttccgc atggggaaat acgcggatcg tcttctgaaa tactatgaag 46201 aaaacccgac attcattcag ccagaatcac gcaaaaacga aatgattaat aactttatca 46261 aacctggact tgaggatttg gcagtatcac gtaccacttt tgattggggc gtgaaggtgc 46321 cggaaaatcc aaagcatgtt gtatatgttt ggattgacgc actatttaac tatttaacgg 46381 cactcggtta tgatacagaa aatgatgagc tttatcaaaa atattggcct gccgatgttc 46441 atttagtcgg taaggagatt gtacgattcc atactattta ctggccaatt atgctgatgg 46501 cgctggatct tccgctgcca aagcaagtat tcgcgcatgg ctggcttttg atgaaagacg 46561 gaaaaatgtc gaaatcaaaa ggaaacgttg tagatccggt tacattaatt gaacgctatg 46621 gtttagacga acttcgctat tacttgcttc gcgaagtgcc gttcggatca gacggtgttt 46681 tcacgccgga aggatttgtt gagcgaatca actatgattt agcgaatgat ttaggaaatc 46741 tattgaatcg tactgttgcg atgattaata agtattttga cggacaaatc ggttcttaca 46801 aaggtgctgt tacggaattt gaccatacgc tcacttctgt tgctgaagaa acagtgaaag 46861 cttatgagaa agcaatggaa aatatggagt tctcggtagc actttcgact ttatggcagc 46921 tcatcagccg cacaaacaaa tacattgatg agacagctcc atgggtgctt gcgaaagatc 46981 cggcaaaaga agaagaattg cgatcagtta tgtatcatct cgctgaatca ttgcgtattt 47041 cagcggtact gcttcagcca ttcttaacaa aaacacctga aaaaatgttc gagcagctgg 47101 gcattactga tgaatcttta aaagcttggg acagcattac agctttcggc cagctgaaag 47161 atacaaaagt acaaaaaggc gagccattgt tccctcgttt agaggcagaa gaagaaattg 47221 cttacatcaa agggaaaatg caaggttcag caccagcgaa agaagaaaca aaagaagaag 47281 agcctcaaga ggtcgatcgt ttacctgaaa ttacgattga tcaatttatg gatgtagagc 47341 ttcgcgtagc tgaggtcatt gaggcagagc cagtgaaaaa agcagaccgt ttattgaagc 47401 tgcagcttga tcttggtttt gaaaagcgcc aagtggtatc cggcattgcg aagcattata 47461 cgcctgaaga gcttgttgga aaaaaactcg tttgtgtaac aaatctaaaa ccggttaaac 47521 tcagaggaga gctttctcaa ggtatgatcc ttgcaggaga agcagacggc gttttaaagg 47581 tcgtatctat cgatcagtcg ttaccaaaag gcacaagaat taaataatga taaacaaaag 47641 gtgtttcacg tgtaacaatt cgtcgaacac cttttgtgtt tcgacaagaa aggagttttt 47701 cacttatgtt gtttgacact cacgcgcatt taaatgcaga acaatatgat actgatcttg 47761 aagaggttat tgaacgggca aaagctgaaa aagttgaacg aattgtcgta gttggttttg 47821 accgtccgac gattacccgt gcgatggaaa tgattgagga atatgatttt atttatgcag 47881 ccattggctg gcaccctgtt gacgctattg acatgacaga ggaagactta gcgtggatta 47941 aagagctttc tgctcatgag aaagtggtag cgatagggga aatgggactg gattatcatt 48001 gggataaatc acctaaagat attcaaaaag aggtgtttag aaatcaaatc gccttagcga 48061 aagaggtcaa tttgcctatt atcattcata accgtgatgc aacggaggat gtcgtgacca 48121 ttttgaaaga ggaaggcgca gaagctgtgg gcggaatcat gcactgcttt acaggaagtg 48181 cggaagtggc aagagaatgc atgaaaatga atttttattt atcatttggg ggaccggtga 48241 catttaaaaa tgcgaagaaa ccgaaggaag tagtgaagga aattcccaat gaccggctgc 48301 tgattgaaac ggactgcccg tttctcacac cgcacccttt ccgcgggaaa agaaatgagc 48361 caagctatgt gaaatatgtg gcagaacaaa tcgccgaatt aaaagaaatg acctttgaag 48421 agattgcttc catcacgact gaaaatgcga aaagactttt ccgtataaac tgacaaaaaa 48481 cgctagcggg ttttgtaaga gcttgtccct tacagcgttt ttctataaaa gttctacatg 48541 ctttcttctc ctcataggat aggtttgtcg acaagtcttt cttccgtttc tcagtgtatt 48601 tcaggataat gaagaggaca ctgagctttt gggagaaaga gaagggaggg ttgacagcct 48661 tttagatact ctatataatc tctccgagga gaaggaggcg tttttcatca cacaaaaaat 48721 gaaaaagctg ttttccgtaa agcttagcaa aagcaaagtc attctggttg ctgcttgttt 48781 gcttttggca ggaagcggga ctgcgtacgc ggctcatgag ctgacgaaac aatcagtctc 48841 agtttctatc aatggcaaaa agaaacatat acgcacacat gcaaatacag tcggtgatct 48901 tttggagacg cttgatataa agacaagaga cgaagacaag atcacacctg ctaaacagac 48961 aaagataaca gcagacatgg acgttgtgta tgaggctgca aaacctgtga agcttacaat 49021 aaacggggaa gaaaagacgt tatggtcaac agcaaaaacg gtcggtgcat tactggacga 49081 acaagatgtt gatgtgaaag aacaagatca aattgatccc gcaatagata cagatatttc 49141 gaaagacatg aagattaaca tagagcccgc atttcaggtt actgtgaatg atgcagggaa 49201 acaaaagaag atctggacga cttcgactac ggtcgctgac tttttaaaac agcaaaagat 49261 gaacataaaa gacgaagata aaatcaagcc tgcgttagat gcaaagctga cgaaaggaaa 49321 ggctgatatt acaattactc gtatcgaaaa ggtcaccgat gtagttgaag agaagattgc 49381 gttcgatgtg aaaaagcaag aagacgcttc tcttgaaaaa gggaaagaaa aggtcgtcca 49441 aaaaggaaaa gaaggcaagc taaaaaaaca tttcgaagtc gttaaagaaa acggtaaaga 49501 agtgtccaga gagcttgtaa aagaagaaac agctgaacaa agcaaagata aagtgattgc 49561 tgtcggcaca aagcaaagca gtccaaaatt tgaaacggtc agtgcttcag gtgattcaaa 49621 aacagttgtg tcccgcagca atgaatcaac aggcaaagtc atgactgtat catctacggc 49681 ttatacggca agctgcagcg gttgttcagg acatacagcg acaggcgtca atttaaaaaa 49741 taatccgaat gccaaagtca tcgctgtgga tccaaatgtc attccgctag gctccaaagt 49801 ccacgtggaa ggctatggat atgccattgc tgcagatacc ggttcagcga ttaaagggaa 49861 caagatagac gtctttttcc cagagaaatc atcggcgtac cgatggggaa ataaaacagt 49921 caaaattaaa atcttaaatt agtatatact tatgtattca gagggttttg cgccctctgt 49981 ttttttcgtt ataatagaca aagtgcattt tctgcttatt agacgctcga tataagaaaa 50041 agtttcatga atatacaaaa gtttttattt tgtcttggag gaaataatga aaattaaaga 50101 gatcattgtg gtcgaggggc gtgacgatac ggcccgcatc aaattggctg ttgatgcaga 50161 cacaattgaa acaaatggtt cagccatcga tgatcatgtg attgaccaaa tccgtttggc 50221 ccagaagacg agaggcgtca ttattttaac ggatccggac tttccgggag agaagattcg 50281 caaaaccatc tcagaggctg tacccggctg taagcatgca tttttgccaa aacatcttgc 50341 caaacctaaa aacaagcggg gaattggtgt ggagcatgca tcggttgaaa gcattagggc 50401 atgtttagaa aatgtgcatg aggagatgga agcgcagccg agtgacattt cagctgagga 50461 tttgattcat gccggactaa taggcgggcc tgcggccaaa tgccgccggg aacgactggg 50521 tgatctgttg aaaatcggct atacaaatgg caaacagctt caaaaacggc tgcaaatgtt 50581 tcaaattaaa aaaagtgatt ttatgagtgc gctcgatacc gttatgcggg aggaacagaa 50641 tgaataaaga tattgcgaca ccgattagaa cgaaagagat actgaagaaa tacggttttt 50701 cttttaaaaa gagcttagga cagaatttct taattgatac gaacatttta aacagaattg 50761 ttgatcacgc ggaagtgacg gagaaaacag gtgtcattga aatcggcccg ggaatcgggg 50821 ctttaaccga acagcttgcc aagcgggcga aaaaggtcgt ggcatttgag attgaccagc 50881 gattattgcc gattctgaag gatacactgt caccttacga aaatgtcact gtcattcatc 50941 aggacgtgtt aaaggctgat gtcaaatcag tcattgaaga acaatttcaa gattgtgatg 51001 agatcatggt agttgccaac cttccttatt acgtaacaac accgattatc atgaaactgc 51061 ttgaagaaca tcttccgctg aaagggattg tggttatgct gcaaaaagaa gtggctgagc 51121 gcatggcggc tgatccttca tctaaggaat acggctcgct ttcaatcgcg gtgcagtttt 51181 atacagaagc caaaacggtg atgatcgtcc cgaaaaccgt atttgttcct cagcctaatg 51241 tcgattccgc agtcattcgt ctgattctcc gagacggccc ggcagtggac gtggaaaacg 51301 aatccttttt ctttcagctc atcaaggcaa gctttgcaca gcgccgtaaa acgctgctca 51361 ataacttagt taacaatctg cctgaaggaa aagcacaaaa atcaacgatt gaacaagtgc 51421 tcgaagaaac aaatattgac ggtaagcgcc gaggtgaatc cctgtctatt gaggaattcg 51481 cagcgctgtc taacggattg tataaagccc ttttctaaaa gggctttttg ttttgcgcac 51541 cacatggact gccgctacat aggctagaga aggacctttc attcaatgat aagaaaaaac 51601 ttggactcag cgaaaaaagg cgctttctca aggctctttc tttcatgatg aggcttagtc 51661 tatgtgtgga gtgaggaacg tgcaatttca aataggggat atggtagcca gaaaatccta 51721 tcagatggat gttttgtttc gaattatagg aatagagcaa acaagcaaag gaaattcaat 51781 tgccattttg catggagatg aagtcaggct gattgctgat tcggattttt ctgatctggt 51841 ggcagtgaaa aaggatgagc agatgatgcg gaaaaagaaa gatgagagca gaatgaatga 51901 gtcgctcgaa ttgctccgcc aagattataa gctgctcaga gaaaagcagg agtactatgc 51961 gacaagccaa tatcagcatc aggagcatta tttccatatg ccgggcaaag tgcttcatct 52021 ggatggtgac gaagcatatt tgaaaaaatg cctgaatgtc tataaaaaaa ttggagtgcc 52081 ggtctatggc atccattgcc atgaaaagaa aatgtctgct tctattgaag tattgctcga 52141 caaatatcga cctgacatcc tggtgatcac agggcatgat gcgtactcga agcaaaaggg 52201 cggtattgat gatttgaatg cgtacagaca ttctaagcac tttgttgaaa cagttcaaac 52261 agcccgaaaa aagatccctc acttagatca gcttgttatt tttgcggggg cctgccaatc 52321 ccattttgaa tcactcatca gagcgggtgc gaattttgca agttcaccgt caagagtcaa 52381 tattcatgcg cttgatccgg tatatatcgt cgcgaagatc agctttacgc cgtttatgga 52441 acggattaat gtatgggaag tgctccgtaa tacgctgaca agagagaaag ggcttggagg 52501 tattgaaaca agaggagttc tgagaattgg tatgccttat aagtccaatt aacagttgaa 52561 aacctgcata ggagagctat gcgggttttt tattttacat aatgatacat aatttaccga 52621 aacttgcgga acataattga ggaatcatag aattttgtca aaataatttt attgacaacg 52681 tcttattaac gttgatataa tttaaatttt atttgacaaa aatgggctcg tgttgtacaa 52741 taaatgtagt gaggtggatg caatggcgaa gacgttgtcc gatattaaaa gatcgcttga 52801 tgggaattta ggtaaaaggc tgacgttaaa agcaaacggt ggccgccgaa aaacgattga 52861 gcgttcgggc attttagctg agacgtaccc ttctgttttt gtgatacaac tagatcaaga 52921 cgagaactcg tttgaaagag tttcatacag ttatgctgat attttgactg agactgttga 52981 gctgacattt aatgatgacg ccgcaagctc agtggcattt taacgggcag tgaacctttt 53041 gtttactgct ttttgttttg cccttttttg gtttccaata attttaacga aagttccatc 53101 tgatttaaca aaagataaaa cagtcacata ttatcgtgac gtgcacgaat ggctatcact 53161 tctaaaaaag gagttgtttc gtttgggcag acgtcgtgga gttatgtcag atgagtttaa 53221 atatgagctg gctaaagacc ttggttttta tgacacagta aaaaatggag gctggggtga 53281 aattcgggcc cgcgatgccg gtaacatggt gaagcgtgct attgaaatcg ccgaacagca 53341 aatggctcag aatcagaata accgataagg atgtgacccg ggggacgtgc tgttccctgg 53401 tttttttatt ttggatataa atacataatg ggctgaatat ggatatgttc atcctgtact 53461 tcaaatgtga tacaatgttc atacttatgt ttagatggag aagtaggtga aagctatgcg 53521 tattttagaa aaagcgccag ctaagatcaa tctgtcactt gacgtcaccc gaaaacgccc 53581 ggatggctat catgaagtcg aaatgatcat gacgacaatt gatttagctg atcgaattga 53641 attgacggag cttgcagagg atgaagtgag ggtttcctcc cacaaccgat ttgtgcctga 53701 tgaccaaaga aacttagctt atcaggctgc caagctgatc aaggacagat acaacgtgaa 53761 aaagggagtt tccatcatga ttacgaaggt aattccggtg gctgccggtc ttgccggcgg 53821 aagcagtgat gcggcggcga cactcagagg gctgaacaga ctgtggaatt taaatctgtc 53881 cgcggaaacg cttgctgagc ttggagcgga aattggctct gacgtttcat tttgtgtcta 53941 tggcggaact gcattagcaa cagggcgcgg cgagaaaatt aaacatatca gcacgcctcc 54001 gcactgctgg gtcattttag cgaagccgac aatcggtgtt tcaactgctg aagtgtacag 54061 agcgctgaaa ctggatggta tagagcatcc cgatgtacaa ggcatgatcg aggcgataga 54121 agaaaagagt tttcagaaga tgtgcagccg gttaggcaat gtgcttgaat ctgttacact 54181 cgatatgcat cctgaagttg cgatgatcaa aaaccagatg aaacgctttg gtgcagatgc 54241 cgtgttaatg agcgggagcg gcccgacagt gtttggactg gttcagtatg agtcgaaggt 54301 gcagagaatt tataacgggt taagaggctt ctgcgatcaa gtttatgcgg tgagaatgat 54361 cggcgaacag aacgctcttg attaaatccg tatgttaagt tatattgatc ttaaaatatt 54421 cggattttgg gggtgagttc atgaagtttc gtcgcagcgg cagattggtg gacttaacaa 54481 attatttgtt aacccatccg cacgagttaa taccgctaac ctttttctct gagcggtatg 54541 aatctgcaaa atcatcgatc agtgaagatt taacaattat taaacaaacc tttgaacagc 54601 aggggattgg tactttgctt actgttcccg gagctgccgg aggcgttaaa tatattccga 54661 aaatgaagca ggctgaagct gaagagtttg tgcagacact tggacagtcg ctggcaaatc 54721 ctgagcgtat ccttccgggc ggttatgtat atttaacgga tatcttagga aagccatctg 54781 tactctccaa ggtagggaag ctgtttgctt ccgtgtttgc agagcgcgaa attgatgttg 54841 tcatgaccgt tgccacgaaa ggcatccctc ttgcgtacgc agctgcaagc tatttgaatg 54901 tgcctgttgt gatcgttcgt aaagacaata aggtaacaga gggctccaca gtcagcatta 54961 attacgtttc aggctcctca aaccgcattc aaacaatgtc acttgcgaaa agaagcatga 55021 aaacgggttc aaacgtactc attattgatg actttatgaa agcaggcggc accattaatg 55081 gtatgattaa cctgttggat gagtttaacg caaatgtggc gggaatcggc gtcttagttg 55141 aagccgaagg agtagatgaa cgtcttgttg acgaatatat gtcacttctt actctttcaa 55201 ccatcaacat gaaagagaag tccattgaaa ttcagaatgg caattttctg cgttttttta 55261 aagacaatct tttaaagaat ggagagacag aatcatgaca aaagcagtcc acacaaaaca 55321 tgccccagcg gcaatcgggc cttattcaca agggattatc gtcaacaata tgttttacag 55381 ctcaggccaa atccctttga ctccttcagg cgaaatggtg aatggcgata ttaaggagca 55441 gactcatcaa gtattcagca atttaaaggc ggttctggaa gaagcgggtg cttcttttga 55501 aacagttgta aaagcaactg tatttatcgc ggatatggaa cagtttgcgg aagtaaacga 55561 agtgtacgga caatattttg acactcacaa accggcgaga tcttgtgttg aagtcgcgag 55621 actcccgaag gatgcgttag tcgagatcga agttattgca ctggtgaaat aataagaaaa 55681 gtgattctgg gagagccggg atcacttttt tatttacctt atgcccgaaa tgaaagcttt 55741 atgacctaat tgtgtaacta tatcctattt tttcaaaaaa tattttaaaa acgagcagga 55801 tttcagaaaa aatcgtggaa ttgatacact aatgctttta tatagggaaa aggtggtgaa 55861 ctactgtgga agttactgac gtaagattac gccgcgtgaa taccgatggt cgcatgagag 55921 cgattgcatc catcacgctg gatcacgaat ttgttgtaca tgatattcgt gtgattgatg 55981 gaaacaatgg tcttttcgtt gcgatgccga gtaaacgcac ccctgatgga gagttccgcg 56041 atattactca tcctattaat tcaagcacgc gaggaaagat tcaagatgcc gtgttaaatg 56101 agtatcatcg tctgggtgac actgaagcat tagaattcga agaagctgga gcttcttaaa 56161 aaataaccaa aaagcaagga ctgctgaaag ggctgacata agccttttgc cggcggtcct 56221 tttttaattc tgatttttca aacttagttg cactcaatag aaaattcttg cacttcatga 56281 agtctccttg aaatcagaag atatttagga tatatttttc tatggataaa agggatattg 56341 gaggccaata aatggataag cggtttgcag ttgttttagc ggctggacaa ggaacgagaa 56401 tgaaatcgaa gctttataaa gtccttcatc cagtttgcgg taagcctatg gtagagcacg 56461 tcgtggacga agccttaaaa ttatctttat caaagcttgt cacgattgtc ggacatggtg 56521 cggaagaagt gaaaaagcag cttggtgata aaagcgagta cgcgcttcaa gcaaaacagc 56581 ttggcactgc tcatgctgta aaacaggcac agccatttct tgctgacgaa aaaggcgtca 56641 caattgtcat ttgcggagat acgccgcttt tgacagcaga gacgatggaa cagatgctga 56701 aagaacatac acaaagagaa gcgaaagcta cgattttaac tgcggttgca gaagatccaa 56761 ctggatacgg ccgcattatt cgcagcgaaa acggagcggt tcaaaaaata gttgagcata 56821 aggacgcctc tgaagaagaa cgtcttgtaa ctgagatcaa caccggtacg tattgttttg 56881 acaatgaagc gctatttcgg gctattgatc aggtgtctaa tgataatgca caaggcgagt 56941 attatttgcc ggatgtcata gagattctta aaaatgaagg cgaaactgtt gccgcttacc 57001 agactggtaa tttccaagaa acgctcggag ttaatgatag agttgctctt tctcaggcag 57061 aacaatttat gaaagagcgc attaataaac ggcatatgca aaatggcgtg acgttgattg 57121 acccgatgaa tacgtatatt tctcctgacg ctgttatcgg aagcgatact gtgatttacc 57181 ctggaactgt gattaaaggt gaggtgcaaa tcggagaaga tacgattatt ggccctcata 57241 cggagattat gaatagtgcc attggcagcc gtacggttat taaacaatcg gtagtcaatc 57301 acagtaaagt ggggaatgat gtaaacatag gaccttttgc tcacatcaga cctgattctg 57361 tcatcgggaa tgaagtgaag atcgggaatt ttgtagaaat taaaaagact caattcggag 57421 accgaagcaa ggcatctcat ctaagctatg tcggcgatgc tgaggtaggc actgatgtaa 57481 acctgggctg cggttcaatt actgtcaatt atgatggaaa gaataagtat ttgacaaaaa 57541 ttgaagatgg cgcgtttatc ggctgcaatt ccaacttggt tgcccctgtc acagtcggag 57601 aaggcgctta tgtggcggca ggttcaactg ttacggaaga tgtacctgga aaagcacttg 57661 ctattgccag agcgagacaa gtaaataaag acgattatgt gaaaaatatt cataaaaaat 57721 aatcctaaat tcggaggttt atccatgtct aatcaatacg gagataagaa tttaaagatt 57781 ttttctttga attcgaatcc agagcttgca aaagaaatcg cagatatagt tggagttcaa 57841 ttagggaaat gttctgtcac aagatttagt gacggggaag tccaaattaa tatcgaagaa 57901 agtattcgcg gatgtgattg ttacatcatc cagtctacaa gtgaccccgt taacgagcat 57961 attatggaac tgctgattat ggtagatgcg ttaaaacgcg cttctgcaaa aacgattaac 58021 attgttattc cttattacgg ttatgcgcgt caagacagaa aagcaagatc ccgtgagcca 58081 atcacagcta aacttttcgc taacctgctt gaaacagccg gtgcgactcg tgtgattgca 58141 cttgacctgc atgcgccgca aattcaagga ttctttgata taccgattga ccacttaatg 58201 ggtgttccga ttttaggaga atattttgaa ggcaaaaatc ttgaagatat cgtcattgtt 58261 tcaccagacc atggcggtgt gacacgtgcc cgcaaactgg ctgaccgact aaaagcgcca 58321 attgcgatta tcgataaacg ccgtccgcgt ccaaacgtgg cggaagtcat gaatattgta 58381 ggtaacatcg aagggaagac tgctatcctc atcgatgaca ttattgatac tgcaggtacg 58441 attacacttg ctgctaatgc gctcgttgaa aacggagcga aagaagtata tgcatgctgt 58501 acacaccctg tactatcagg ccctgcggtt gaacggatta ataattcaac aattaaagag 58561 cttgttgtga caaacagcat caagcttcct gaagaaaaga aaattgaacg ctttaagcag 58621 ctttcagtcg gaccgcttct ggccgaagcg attattcgcg ttcatgagca gcaatcagtc 58681 agctatctgt tcagctaaac catttttcga ggtttaaatc cttatcgtta tgggtattgt 58741 ttgtaatagg acaactaaaa cgacaagagg atggtgctga atatggcaac tttaacggca 58801 aaagaaagaa cggactttac tcgttcgtct cttcggaata tccgtacttc aggacatgtt 58861 ccaggtatca tatatgggaa ggatacgggt aacaaacctg tgtcattaga cagtgtggag 58921 ctcatcaaaa cgctgaggga cgaaggcaaa aatgcagtca ttacgcttga ggtcagcgga 58981 gaaaaacact cagtcatggt aacagacctg cagacggacc cgctgaaaaa tgaaatcact 59041 catgctgatt ttcaagtagt taatatgagt gaggacattg aagtggaagt tccgattcat 59101 ctgaccggag aagccattgg agtgaaaaac ggaggcgtac tgcagcagcc gttatatgca 59161 cttactgtaa aggccaagcc aaaagccatt ccgcaaacga ttgaggctga tatttcaagc 59221 ctcgatgtaa atgaagtact gacgattgcg gatttgcctg ctggcggtga ctactccttt 59281 aatcatgaat cagatgaggt tgtggcttca atccttcctc cgcagcagca ggaagcagct 59341 gaggtcgatg aagaggaatc tgccgatgct cagcctgaag gtgaaaacga acaataatag 59401 cttaaggcgt aaccctcccg cggttacgtc ttttgtgcta gaatgagaag aattatagcc 59461 cgtttatgaa gacgggagtt atgtgactaa gggaggattc gccatgcttg tgattgccgg 59521 tctcggaaac ccggggaaga actatgaaaa tacacggcat aatgtcggat ttatggtgat 59581 agatcagctt gcaaaggaat ggaatataga gctgaatcaa aataaattta acggattata 59641 cggaaccgga tttgtttccg gcaaaaaggt tctacttgtt aaaccgctta catatatgaa 59701 tttatcagga gaatgtttgc ggcctttaat ggactactat gatgtcgata acgaagattt 59761 gacagtcatt tacgacgacc ttgaccttcc gactggcaag atccgtttaa gaacgaaagg 59821 aagcgccgga gggcacaatg gcatcaaatc actgatccag catcttggaa cgtccgagtt 59881 tgaccgtatc cgcatcggaa tcggccggcc tgtaaacggc atgaaggtcg ttgattatgt 59941 gttaggctcc tttaccaagg aggaggcacc tgagatcgaa gaagcggttg ataaatctgt 60001 gaaggcttgt gaggcttctt tgagtaaacc gtttttagaa gtcatgaacg aatttaacgc 60061 aaaggtataa aatgtaacaa caaagtccat actacaccaa aatgactttt tcatcaggag 60121 gacccttgta tggctttgca ttattattgt cgtcattgcg gagtgaaagt aggcagtctc 60181 gaatcttcaa tggtatcgac agactcactt ggatttcagc acttaacaaa tgaggaaaga 60241 aacgatatga tttcttataa agaaaatgga gatgtccatg ttttgacgat atgtgaagac 60301 tgccaagagg cgcttgaccg aaatccgcat taccacgaat atcacacatt tattcaataa 60361 aaagctttgg tgtagacact agaccaaagc gtttttctgt tctcgcagga aacagagagg 60421 aggggccata tggacaacat tcaaaccttt ataaaagaaa gcgatgactt taaatccatc 60481 atcaacggtt tacacgaggg cctgaaggaa cagctgctcg cgggtctgtc gggttccgcg 60541 cgttctgttt ttacttctgc tctggctaat gaaacgaata agcctatctt tctcatcacc 60601 cataacttat atcaagccca gaaagtaaca gatgatctga cttcacttct agaggatcgg 60661 tctgtccttt tgtaccccgt caatgaactc atttcatcag aaatcgcagt tgcaagccct 60721 gaattgcggg cgcagcgatt agatgtcatt aatagactaa cgaatggaga agcgccaatt 60781 gtcgttgctc cggtagctgc aatcagaaga atgctgccgc ctgttgaggt gtggaaaagc 60841 agccagatgc tcattcaagt aggccatgat attgaacctg accagcttgc ctcacggctg 60901 gtagaggtag ggtatgagcg gtctgatatg gtttctgcgc ccggggaatt cagtattcgc 60961 gggggaatca ttgacattta tccgctgact tcagagaatc cggtgagaat tgaacttttt 61021 gacaccgagg tggattcaat ccgcagcttt aattcagatg atcagcggtc aattgagacc 61081 cttacctcga tcaatatcgg tcccgcgaag gaattaatta tcagaccgga agaaaaagcg 61141 cgggcgatgg agaaaatcga tagtggtctt gccgcgagct tgaaaaaatt aaaggctgac 61201 aaacaaaaag aaatacttca tgcgaatatt tctcacgata aagaacgctt gtctgaaggc 61261 cagacagatc aggagctcgt gaagtatctc tcatatttct atgaaaagcc tgctagttta 61321 ctagattata cacctgataa tacacttctg attttggatg aagtcagtcg gattcatgag 61381 atggaagaac agcttcaaaa agaagaagcg gagtttataa caaatcttct tgaggaaggg 61441 aagattttgc atgacattcg tttgtcattc agcttccaaa aaatagtggc tgagcaaaaa 61501 cggcctctgc tgtactactc tttatttttg cggcatgtac accatacgag cccgcaaaat 61561 atcgtcaatg tgtcaggccg gcaaatgcag agtttccatg gccaaatgaa cgtgcttgcg 61621 ggcgaaatgg agcgttttaa aaaatcaaat ttcactgttg tgttcttagg agcaaacaag 61681 gaacgtacgc agaaattgtc atctgttttg gctgattatg atatcgaggc cgccatgaca 61741 gacagcaaaa aagcgcttgt tcagggacag gtctatatca tggaaggcga gctccaatcg 61801 ggatttgagc tgccgttaat gaagcttgcc gttatcacgg aagaagaact gttcaaaaac 61861 cgtgtaaaga agaagccgcg aaaacagaag cttaccaatg cagagcgcat caaaagctat 61921 tctgagcttc aaattggaga ttatgtcgtt catattaatc acgggatcgg aaaatacctg 61981 gggattgaaa ctcttgaaat caacggcatt cataaagact atttaaatat acattatcag 62041 ggcagtgaca agctttacgt ccctgtagaa caaattgatc aggtccaaaa atatgttggc 62101 tccgaaggaa aagagccaaa gctgtataaa ttaggcggaa gtgaatggaa gcgggtcaag 62161 aaaaaagtag agacatccgt tcaggatatt gctgatgact taattaagct gtatgccgaa 62221 agagaagcga gcaagggcta tgcgttttct cctgaccatg agatgcagcg tgaattcgaa 62281 tcggctttcc cttatcaaga gactgaggat cagctccgtt ctattcacga aatcaaaaaa 62341 gacatggaaa gagaacgtcc gatggaccgc ttgctgtgcg gagatgtggg ctacggtaaa 62401 acagaggttg ccatacgtgc cgcgtttaag gcgatcggtg acggaaagca ggtagctctg 62461 ctcgttccga caaccatttt ggcacagcag cactatgaaa ccataaaaga gcgcttccag 62521 gactatccga ttaatatcgg ccttctcagc aggttcagaa cgagaaaaga agcaaacgaa 62581 acaatcaaag ggctgaaaaa tggaacggtt gatatcgtca tcgggacgca tcggctgcta 62641 tcaaaggatg tcgtgtataa agacttaggg ctcctcatca ttgatgaaga gcagcgtttc 62701 ggtgtaaccc ataaagaaaa gatcaagcaa ataaaagcca atgttgatgt attaacgtta 62761 acagcaacgc cgattccgcg tacgctgcat atgtctatgc ttggcgtaag ggacctttca 62821 gtcatcgaga ctccgccgga aaatcgcttc cccgtacaga cgtatgttgt ggaatataac 62881 ggcgctcttg tcagagaggc gattgaacgt gagcttgcac gcggaggcca ggtctatttc 62941 ttgtacaacc gggtagagga cattgagcgg aaagcggatg aaatttcaat gctagtccct 63001 gacgcgaagg tagcatatgc gcatgggaaa atgacagaaa atgaattaga aaccgttatg 63061 ctaagcttcc ttgaaggaga atcagacgtt ctcgtcagca caaccattat cgaaactggc 63121 gtggacatcc caaacgtcaa tacgctgatc gtatttgacg ccgacaagat gggactttct 63181 cagctttacc agctgcgggg gcgtgtcggc cgttctaacc gtgtggcgta tgcgtacttc 63241 acgtatcgcc gggataaagt gctgacagaa gtggctgaaa aaaggctgca ggctattaaa 63301 gaattcacag agttaggttc cggttttaaa atcgcaatgc gtgacttaac gattcgcgga 63361 gccgggaatc ttcttggtgc ccagcagcat ggcttcatcg attcggtcgg atttgacctc 63421 tattcacaaa tgctgaagga ggccattgag gagcgtaaag gagacacagc gaagacagag 63481 cagtttgaaa cagaaattga tgtcgagctt gatgcgtata ttccggaaac ttatattcaa 63541 gacggcaaac agaaaattga tatgtataaa cgcttcaggt ctgtggcgac aatcgaagag 63601 aagaatgagc ttcaagatga aatgatcgac cgctttggaa actatccaaa agaagtcgaa 63661 tacttgttta ctgttgcaga aatgaaagtc tatgcgagac aggaacgtgt cgagctgatt 63721 aagcaggata aagatgctgt cagattgacg atttctgaag aagcaagtgc tgaaattgac 63781 gggcagaagc tgtttgagct tggcaatcaa tatggcagac aaatcggact gggaatggaa 63841 gggaaaaaac tcaaaatctc catacagacg aaaggccgta gtgctgatga atggctcgac 63901 accgtgctgg gcatgctgaa gggcttaaaa gatgtgaaaa agcaaaccat ttcatcaacg 63961 taaattttgt tactctctgg tgtatattac atttgatgtg acggatacta atttcaagcg 64021 aggcggaagg tacataaagt aactgcttta ggtctttccc acatgtatat accatcaaat 64081 gaaagagagg caccagagat gaaagcaacc ggtatcgtac gtcgtattga tgacttaggt 64141 cgggtcgtga ttcctaaaga aattcgaaga actctgagaa tcagggaagg cgatccgctt 64201 gagatttttg tagatcgtga cggagaagtg attttgaaaa agtactctcc gatcagtgag 64261 cttggagact ttgcaaagga gtatgcagac gcgctttacg acagcctcgg ccattcagtg 64321 ctgatttgtg atcgtgatgt atatattgcc gtgtccggca gctccaaaaa agattactta 64381 aacaagtcaa tcagcgaaat gctggaaaga acaatggatc agcgcagctc cgtgcttgag 64441 agtgatgcga aatcagtaca gcttgtgaat ggaattgatg aggacatgaa ttcttatact 64501 gtaggcccaa ttgtggcgaa cggtgatccg ataggtgctg tggtgatctt ttcaaaagat 64561 cagacaatgg gcgaagtaga gcataaagcc gttgaaacag cagctggatt tttggctcgt 64621 caaatggaac agtaggtctt attcctttct tcgaaaatag gtatgtaaag aacagctctc 64681 cttgggacgc tgttcttttt catgcgtgcc gaaaaaggaa tccaagggtt gggatgtggt 64741 ataataacct cgtttttatt tgtgccgcgg taatacgtga accgtattgc ccctgacgtt 64801 gggaaggagc ttttggatgg acgattcaat aggcgttaaa cggcattgga tttggcaggg 64861 ggcttttgtt ttaattctgg caggcgtcat cacaaaaatt ttaagcgctg tttacagagt 64921 cccgtttcaa aacattgtcg gcgatgttgg attttatata tatcagcagg tatacccctt 64981 tcttggtatt gcggtcatgc tgtccacatc aggatttcca gtcattattt caaagctgat 65041 gaatgattat agtgaaaaaa atcatcacac catattaaaa atatcagcgt tgtttttgtc 65101 tttaatcggt attttattat ttctttgttt atatctgggt gctgttccta ttgcactctt 65161 tatgggagat tcgcatctag ccgtgttaat tcaagtggcc gcatacgcgt ttctgctttt 65221 cccatttgtc gcgttgctaa gaggcggttt tcaggggcgg cacgaaatgc tcccttcagc 65281 cttatcacag atgacagagc agtttctgcg tgttgcggtg ctcttgggtt tatcattttg 65341 gctcgtgaaa aagggagcct cgctttatac tgcgggagcg gcagccgctt caggctctct 65401 tgccggaagt ttggttgcat tgataatact ggggtttttt tggttcaaaa cgaaaagaga 65461 caaccaaacg gataggcaaa acgaaaatgt catcacaaca aaagaattga cgaaaaaact 65521 gcttttatat tcggtcacaa tttgtgtaag cagtttgctg cttttgttta tccagcttgt 65581 tgatgctttg aatttatatg cattgctttc gggtggtgag gcaagcgaag aagcaaaatg 65641 cctaaagggg atctatgatc ggggacaacc cttgttgcag ctcggttcag tttttgccgt 65701 aagcattgcg acgtcactcg ttccgtatat ttctatggct gtaaaaaaca aagagctgaa 65761 gatcatgaaa gaaaaaatca cgtcatcttt gaaactatgc cttgtgctcg gtacaggcgc 65821 atcggctggg ttgatttgca ttctaaagcc ggtaaatatc atgctgtttc aaaatggaga 65881 agggacaggt gcgttacaag tatttagctg ctccattttg tttgcatcct tggcggtaac 65941 ggcagcggca gtcttacagg gagcgggata cacagttttt cctgcgatag cggtgggcgc 66001 gggtgttgcg gtgaaatggg tgttaaacac acttttggtt ccgcgctatg ggattgaagg 66061 cgcatcgctt gcgacagcgg cttcctttgc ggctgtcgcc ggccttaact tgtatcagct 66121 tcggcaaaag gaatggctcg ataagcttag aggcgttttg attccgatta ttggatctgc 66181 tcttttgatg tcagctgttt tgcttgcgta tacgcgtctc tggactttct tgtttcctgc 66241 aacaggaaga ggagcggctg tgattgagag tctttctgct gttgccattg gtggcgcggt 66301 gtttatttat tgtatgatga gattgggaat atttacagat gaagagctga acagtgtgcc 66361 attcggcagc aagttaagca aattcatgag aaggagagaa caaaatggcg ggtaaaatta 66421 cagtcgtcgg acttggtgcc ggagacatgg accaattgac aattggtata cacaagctgc 66481 tgacgaaggc agatacgctg tatgtcagaa ccaaggatca tcctttaatt gaggagcttg 66541 aaaaagaaac gaagaacatc cgtttctttg atgatatata tgagaaacat gatcagttcg 66601 aggcggtata tgaagaaatt gcagatatcc tctttgaagc ggcgcggcgt gaggacgtgg 66661 tttacgctgt gccgggacac ccttttgtcg cagaaaaaac agttcagctg ctgacggagc 66721 ggcaggaaaa ggaaaacgtt caagtgaaag tcgcgggggg acaaagtttc cttgatgcca 66781 cattcaatgt cttgcaaatt gacccgattg aaggttttca atttgtggat gccggcacat 66841 tgtccgcgga tgagcttgag ctcagacatc atctgatcat atgtcaggtt tacgaccaaa 66901 tgacggcttc tgaagtcaag ctgacattga tggagaagct gcctgatgat tatgaggtcg 66961 tcattgtgac tgcagcaggc agccgtggcg aggagatcag gacagtgcca ttatttgagc 67021 tggaccgcaa tgtcgctttg aacaacttaa caagtgtgta tattccgccg attaaagaag 67081 agaagctgct ttatcacgaa ttctccacgt tccgaagcat catcagagag cttcgcggac 67141 ctaatggatg tccgtgggat aaaaagcaga cgcatcagtc attaaagcag tacatgattg 67201 aagaatgtta tgagcttctc gaagctattg acgaagaaga cacagaccat atgatcgaag 67261 agcttggcga cgttttgctt caggtcttgc ttcacgcgca aattggtgaa gatgaaggtt 67321 atttcacaat tgatgatgtc ataaaaggaa tcagtgaaaa aatggtccga agacatcccc 67381 atgtgtttaa agatgttaag gttcaggatg aaaacgatgt tttagccaat tgggaagata 67441 taaaaaaggc cgaaaaaaat acatctgaat catcattact agacagcgta ccgaaaaccc 67501 ttccagctct ttcgaaagca gctaaattgc agaaaaaagc agcgaaggtc ggttttgact 67561 gggaagacgt cagcgatatt tgggaaaagg taagtgagga aatgaaggaa ttttcttctg 67621 aggtttctga agctcctcac gaacacaatc ttaaagctga gtttggcgac attttgttcg 67681 cgctggtgaa tgtagcccgc ttctacaaaa tagagccaga ggaagcgctg accatgacta 67741 atgacaaatt ccggagacgg ttctcgtaca ttgaggaaac agcgaaggaa gagggagtcg 67801 agttggctga tatgtccctt gaggacatgg acaaactgtg gaatgaagca aaagaaactg 67861 agaggagatc atagatatga gattagataa atttttgaaa gtatcacggc tgatcaaacg 67921 gcgtacacta gcgaaggaag tagctgacca aggacgaatc tctattaacg gaaaccaagc 67981 taaagctagc tctgacgtaa aaccgggaga tgaactaacg gtccgcttcg gccaaaagct 68041 tgtaacggtt caagttaatg aattgaaaga cacgacgaaa aaagaagaag ctgcaaacat 68101 gtacacgatt ctaaaagaag aaaaactcgg cgaataggct tgttctaaaa aaacccccca 68161 cctcatacaa tgcagtaata atgctaaaag tatcgaggat atgggggctg aatagatgaa 68221 ttcatattat gatcaaaaag gttcttcgtc tgttccggaa cagcatgatg tgacaatgaa 68281 aggccggaag catttagata tttctggggt taagcatgtg gagagttttg ataacgaaga 68341 attcctgctg gaaacggtga tgggaatgct ctccgtcaga ggccaaaacc tgcagatgaa 68401 aaatcttgat gtggaaaaag ggattgtttc gattaaaggc agggtatttg atttagtgta 68461 cttagacgaa caacaagggg ataaagctaa agggtttttt agcaagttgt ttaaatgacg 68521 ctgacgacac aattctatac aatgctagcg atgtccggta tgggtctctg gcttggtgct 68581 tcgcttgata cataccggct ctttgtcatt cgtgccaaaa cagccagatg gctattattt 68641 attcatgata ttcttttctg gattatgcaa gggctgcttt tcttttatgt cttgcttcat 68701 gtaaatgagg gagaattcag gatttacatc tttttagcgg ttctgctggg cgttgcgacg 68761 tatcagagcc tttgcaaacg aatctatata aaaatactga aattcgtcat ttaccttgtt 68821 gtttctgttt atcaattctt caaaaaactc attcagcacg tgttatttcg tcctattgtg 68881 tggacatgcg gagcgatcat ctggctggcg gcatttttat tcaagaaaac atacagcctg 68941 ataggttttc tcctgctgtg tctatataaa atagtcatgg ttctgtgttt tccgatccgt 69001 tttatcgcga aacaatgttt gaaacttctt cctgtgaaaa tgcgtctaac ttttagacgt 69061 tattttgaaa aaggtgcagg atttctcaaa aagaagaaga aactattgat aaccataaga 69121 acgaccatca cacggttttt gaagagatga aaggaggacc gtctggtttg aatttttcca 69181 gggaacgaac gataactgaa atacaaaacg actataaaga acaagtagaa cggcaaaatc 69241 agctgaagaa acgaagacgc aaagggctgt acagacggtt aactgtattc ggcgccctag 69301 tattcctgac ggcaattgtg ctggcaagct ctgtatggtc ccaaacatct tcccttagtg 69361 caaaagaaga aaagaaagaa cagcttgaaa aagaactgaa aagtttaaag acaaaacaaa 69421 cggatttaaa agaagaaata tccaaattga aggatgagga ttacgtcaca gagcttgcca 69481 gaagggactt attcatgtct ggagacggag aaattatctt caatgtggag aagaagagca 69541 agtagccttg ttgacactta aatttttatt taggtataat taagcaaacg atctttttat 69601 aagcctaagg aggagcactt tttttatgtc gattgaagtt ggcagcaagt tgcaagggaa 69661 aattacaggt attacaaatt ttggagcatt tgttgaattg cctggaggct caaccggtct 69721 cgttcacatt agtgaggtag ctgataatta tgtcaaagac attaacgacc acttaaaagt 69781 cggcgaccaa gttgaagtga aagtcatcaa cgttgaaaaa gacgggaaaa ttggtttatc 69841 tattaaaaaa gctaaagacc gtccgcaagc cagacctaga aatgatttcc gtccgaaaga 69901 atcttttgaa cagaaaatga ataagttttt aaaagacagc gaagatcgct tgtcatcttt 69961 aaaacgcaat acggaatcaa aacgtggagg gcgcggagca agaagaggat aacttgctgc 70021 tttctataaa ataaatgaag catccgttca tcccgacgga tgctttttta ttatcctcat 70081 tctctttaag agtcagaaaa ttacaacatt aaagtttctg ttgacgaaag agacaaacct 70141 ttgtattata taacttgtgc ttagaagcac aaaacaatat ggcggtgtag ctcagctggc 70201 tagagcgtac ggttcatacc cgtgaggtcg ggggttcgat cccctccgcc gctaccatat 70261 ttgtttggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 70321 cgaatcccgt acgggtcatc ctaacaaatc ggtttctctt gcagaagccg atttttttca 70381 tttttagaca acattccgga aattcttttc ataaacgaat atcaaggcag aaaccgtcga 70441 agatttcttt ggtattgtta ccttcttttg acaaaatcct atctgtgctt tcgctataat 70501 gacaggcaac gaatataaca ggtgggagat gagaggaatg gaaaaagcag aaagaagagt 70561 gaacgggcca atggcgggac aagctttgga aaaactccaa tcgtttttta acaggggcac 70621 gaagctggtg actcatcatt tgcattcact gtttttctat aaaggattca tttatgttgt 70681 catcggattt ttgcttggac gggctttcat attatccgag gtgcttcctt tcgcacttcc 70741 tttctttgga gcgatgcttc ttatcagaag agacaaagcg ttttatgcgg ttttggctgt 70801 gcttgcaggt gcgctgacca tatctccaaa gcactcattg ctcatactgg cggcattgct 70861 ggcattcttc gtattttcta aagtggctgc cttcattacc gacgatcgtg ttaaagcgct 70921 cccgattgtc gtgttcttct ccatggctgc agcaagagcc gggtttgttt atgcccaaaa 70981 tggcgtattt acaacctatg attatgtaat ggctatcgtt gaggctggac tatcgtttat 71041 cttaacactg attttccttc agagccttcc gatttttact gtgaaaaaag tgaaacaatc 71101 attaaaaata gaggaaatca tttgctttat gattcttatt gcctctgttt taacggggct 71161 ggctggcttg tcctaccaag ggatgcaggc agaacatata ttggctcgtt atgttgtgtt 71221 gagtttttcc tttattggcg gagcaagcat cggctgtacg gttggggttg tgaccggcct 71281 gattcttggc ttggcgaata tcggaaacct atatcaaatg agtctgcttg ctttttccgg 71341 tttattgggc ggtttgctga aggaagggaa aaaagcgggt gcagcaattg gtttgatcgt 71401 tggatcactt cttatatctt tatatggtga aggctctgcc ggtctgatga caacgctcta 71461 tgagtcatta atcgcagtct gcctgttttt gctcacacct caatctatta cgaggaaagt 71521 ggcgagatat attccgggaa ctgtcgagca tcttcaagag caacagcaat acgctagaaa 71581 aatccgtgat gtcactgctc agaaggtaga ccaattctcc aatgtatttc acgcgctgtc 71641 tgaaagcttt gcaacctttt atcaagcatc agacgaacag acagatgaca gcgaagttga 71701 tctgttctta agcaaaatca cggagcattc ctgccagacg tgctacaaga aaaacaggtg 71761 ctgggtacag aactttgata aaacatatga cttaatgaaa caagttatgc ttgaaacaga 71821 ggaaaaagaa tatgcatcaa accgaaggct gaaaaaagag tttcaacagt attgttctaa 71881 atccaagcag gttgaagagc tgattgagga tgagctcgca catcatcatg cccatttgac 71941 actcaagaaa aaagtccaag acagcaggcg ccttgttgct gaacagcttt taggcgtttc 72001 tgaggttatg gccgactttt ctcgggaaat aaaaagagag cgagaacaac actttctgca 72061 ggaagagcaa atcatagaag cgcttcagca tttcggaatt gagattcagc atgtcgagat 72121 ctatagtctt gaacaaggaa atatcgatat tgaaatgacc attccgttca gcggacatgg 72181 agaaagtgaa aaaatcattg ctcctatgct ttctgacatt ctggaggaac aaattcttgt 72241 gaaagccgaa cagcactctc cgcatccgaa tggatacagc catgtcgcct ttggatcaac 72301 aaaatcatac agggtgtcca cgggagctgc tcacgctgcg aagggcggcg gccttgtctc 72361 cggtgacagc tacagcatga tggagcttgg agccagaaaa tatgctgcag caatcagtga 72421 cggaatgggc aatggcgcaa gagcgcactt tgaaagcaat gaaacgatca agcttcttga 72481 aaaaatcctt gaatcgggca ttgatgaaaa aatagcaatt aaaacgatca acagcatact 72541 gtctctaagg acaactgacg aaatatattc cacgcttgac ctatctatta tcgatcttca 72601 agatgccagc tgtaaatttt tgaaggttgg atcgacgccc agctttatca aacggggtga 72661 ccaggtcatg aaagttcaag cgagcaatct gccaatcggt attattaatg aattcgatgt 72721 ggaggttgtg agtgaacagc tgaaagcggg tgacctctta attatgatga gtgatggcat 72781 ttttgagggg cctaagcatg tggaaaatca cgacttatgg atgaagcgta aaatgaaagg 72841 gttgaaaaca aatgacccgc aggagattgc cgatttgctt atggaagaag tcatccgcac 72901 aagatccggc caaattgagg acgatatgac tgttgttgtc gtccggattg atcacaatac 72961 accgaagtgg gcatccattc ctgttccggc aatctttcaa aacaaacaag aaatttcata 73021 acgcttccgt ataaatcaaa tttcttctgg cgaagatggg aatatatgaa tctgagaatc 73081 ctcgtattct ccaggaggaa tgaatgtgaa caacggacat ttaaatcaaa ttttgctgat 73141 aacggatggc tgctcaaacc atggggaaga cccgcttgca atggctgctt ttgctaaaga 73201 gcaggggatt acggtaaatg tcattggtat aatggaagaa aatcaaattg accctgaggc 73261 aatgaaggaa gtcgaaggga ttgcacttgc cggaggaggc gtgcaccaag tcgtttatgc 73321 atctcagctt tcacaaactg ttcaaatggt aacaaagaaa gcgatgacgc aaaccttaca 73381 aggtgtagtc aatcaagaac tgaaacagat tctcggaaag aatgtggaaa tggaagagct 73441 ttctccggaa aaacgcggcg aagtcatgga agtggtagac gagcttggag aaacggtgca 73501 tcttcaggtt ttggttcttg ttgatacaag tgcaagtatg gcgccaaagc ttccaacagt 73561 aaaagaggcg ctgattgatt tgtctgtaag cctcaattcc cgaattggga ataacgaatt 73621 tgcgatgtgt atatttcccg ggaaaaaaca agaggtcgag cttgtgctga actggacacc 73681 gaagctgcaa tctctttcca cactctttgc aaagctttcg acaggcggca tcacgccgac 73741 aggtccggcg attcgtgaag cgacactgca gtttgaaaaa atacgctcaa gaaggggcat 73801 gctggcagat gatgaacgac gctttgacga gtttggcatg tagcctcaag ccgggtacga 73861 caatcaaagg caagtggaat ggaaacactt atacattgcg taaacagctt ggtaaagggg 73921 ccaatggaat tgtgtatttg gcagaaacat cagatggaca tgttgcctta aaggtgagtg 73981 atgacagcct gtctattact tctgaagtga atgtcttgaa atctttctca aaggcccagt 74041 ccgttacgat ggggccttct ttttttgata cggatgatgc ctatattccc agtgccaata 74101 cgaaagtttc attttatgca atggaataca taaaagggcc gctgcttttg aagtatgtca 74161 gtgataaagg agcagagtgg ataccggtat taatgattca gctgttatcc agcttatcgg 74221 tgcttcacca gcaaggatgg atattcggcg atcttaaacc tgataatctg atcgtaactg 74281 gtccgcccgc aaggatccgc tgcattgatg tgggcggcac gacaaaggaa ggccgggcga 74341 taaaagagta tacggagttt tatgacagag gctattgggg gtatggaaca agaaaggcag 74401 agccatccta tgatctgttc gcagttgcca tgattatgat caacagtgtg cataaaaaag 74461 aatttaagaa aacgaaccag cccaaagaac agcttaggtc tctcatcgaa ggaaacccgc 74521 tgcttcaaaa gtataaaaaa gcgctttttt cagccttgaa cggagattat caatccgcag 74581 atgaaatgaa aaaggatatg ctagacgcgg ggcaaaaagc agcacaaaga aaacagccta 74641 taaaagcatc accgcagcct gccacacgac aaagacagca aaaaccgcgc caaggaaaaa 74701 taacgaagac gcgatatacc ccaaaacaga aaccggctaa gtcggggggg ttatttgaaa 74761 caacgcttat cgtgatcagt gttttagcgc tttatttcgc ctatattatc tttttcttaa 74821 tctgaatggt gcaaactgca gagcctatgc ttcttctttg cttggagggg ttgaaagtgt 74881 taggatatga atatctttaa aatacctgct cattgtgagg aggacattgt gaaaagtgtc 74941 aaagattttt taaacaaaca caatcttacg ttaaaagggg cgacaatcat tgtaggcgtt 75001 tccggcggtc cggactcaat ggctcttctt cacgcgttgc atacgttatg cggccgttca 75061 gcgaatgtta ttgcagctca cgttgaccat cggttcagag gtgcggaatc cgaggaggac 75121 atgcgttttg tccaagctta ttgtaaagct gaacagctcg tgtgcgaaac ggctcaaatc 75181 aatgtaaccg catatgcaca ggaaaaagga ctcaataagc aggctgcagc acgcgattgc 75241 cgctaccagt tttttgagga aatcatgtcg aagcaccaag cggactatct ggctcttgcg 75301 catcatggtg atgaccaggt tgaaacaatg cttatgaaac tggctaaggg tacgcttgga 75361 acgggacttg cgggaatgca gccggttaga cgttttggga cagggcggat catcaggccg 75421 ttcttaacca ttacaaagga agagatcctt cactattgcc atgaaaacgg cttgagctac 75481 cggacggatg aaagcaacgc caaagatgac tacacaagaa acagattcag aaaaacagtg 75541 ctcccgtttt tgaagcagga atctccggat gtgcataaaa ggtttcagaa agtgagtgaa 75601 gcactgacgg aagatgagca attcttacag tcattaacga aagatgaaat gaataaagta 75661 atcacaagcc agtctaatac atcagttgaa atcaattcct ctcaattgct tgccctcccg 75721 atgcctttac aaagaagagg agttcaacta atattaaact atctttatga aaacgttcca 75781 tcatcctttt cagcccatca cattcagcag tttctcgatt gggcggaaaa tggcggtcct 75841 tcaggagtac tggactttcc gaaagggctg aaggtggtca aatcatatca gacatgtttg 75901 tttacatttg aacaatggca gtgcaaaaat gttccctttg aataccaaat tagcggagct 75961 gctgatgaaa cggcagtgct ccctaatgga tatctgatag aggcaaggca ttatgcggac 76021 tcgcctgaag aacatgggaa tgctgttttt atcacaagtg aaaaaaaggt gcgatttccc 76081 ttaacaatcc ggacgagaaa agctggagac cggatcaaac taaaagggat gaacggctca 76141 aaaaaggtaa aggatatatt tattgataag aaattgcctc tccaagaaag agacaactgg 76201 ccgattgtga cggacgcaag cggtgaaatt atctggatac ctggcttgaa aaaatcaatt 76261 tttgaagatc ttgtgattcc aaacagcgac cgcattgtat tacaatatag acagcatgaa 76321 aagtgtaggg ggcaagcaaa atcatgatga aacatgatat cgagaaagta ctgatctcag 76381 aggaagagat acaaaagaaa gtaaaagagt taggtgcaga attaacgagc gagtatcaag 76441 atacatttcc gttggcaatc ggtgtgttaa aaggagcact tccttttatg gcggatctta 76501 tcaagcatat tgatacatat ttggaaatgg atttcatgga tgtatcaagc tacggaaatt 76561 ctacggtttc ttctggagaa gtaaaaatca ttaaagattt ggatacatct gtagagggcc 76621 gggacatctt aattattgaa gatatcatcg acagtgggtt aaccttaagt tatctcgtag 76681 agctcttccg ataccgtaaa gcaaaatcaa ttaagattgt tacccttttg gataaaccga 76741 gcggaagaaa agcggacatc aaagcagact ttgtcggttt tgaagttcct gacgcgtttg 76801 tagtgggtta cggacttgat tatgctgagc gctatcgcaa tctgccttat atcggagtgt 76861 taaaaccggc agtttatgaa agctgatcgg cagcctgctt ccgagatggt tattgtttgt 76921 attggaatga ttttctatgg tactattgaa catagttgtg cttactgtgg gaggaggtaa 76981 ggaatgaatc gggtcttccg taataccatt ttttatttac ttattttatt agtagtaatc 77041 ggggttgtga gctacttcca gacctcaaat ccgaaaacag aaaatatgtc gtacagtacg 77101 ttcatcaaaa acctggatga cgggaaagtt gatagcgtat cggttcagcc tgtcagaggt 77161 gtttatgagg taaaagggca gctgaaaaac tacgacaaag atcaatactt tttgactcat 77221 gttcctgaag gaaagggagc agaccagata tttaacgctt tgaaaaagac agacgtaaag 77281 gttgagcccg cgcaagaaac aagcggatgg gtgacgttcc tgacgaccat catcccattt 77341 gtcattatct ttattctgtt tttcttcctg ctcaatcagg ctcaaggcgg cggcagccgt 77401 gtcatgaact ttggcaagag taaagcgaag ctgtatacag aggaaaagaa acgcgtcaaa 77461 tttaaagacg ttgcaggggc tgacgaagaa aagcaagaac ttgttgaagt tgttgagttt 77521 ctgaaagatc cccgcaagtt tgccgagctc ggcgccagaa taccgaaagg cgtgctttta 77581 gtcggacctc cgggtaccgg taaaacattg cttgccaagg cttgtgcagg agaagccggc 77641 gtacctttct tcagcatcag cggatctgat ttcgttgaaa tgtttgtagg ggtcggtgct 77701 tcccgtgtgc gtgacttgtt tgaaaatgcg aaaaagaatg cgccttgttt gatcttcatt 77761 gatgaaattg acgcagtcgg acgccagcgt ggcgctggtc tcggcggtgg acacgatgaa 77821 cgtgaacaga cgctaaacca attgcttgtt gaaatggacg gattcagcgc taatgaagga 77881 attatcatca ttgctgcgac gaaccgtgcg gacatcttgg acccagcctt acttcgtccg 77941 ggacgttttg accgtcaaat cacagtggac cgcccagatg tcattggccg tgaagctgta 78001 ttgaaagtcc atgcgagaaa caaaccgctg gatgaaacgg ttaacctaaa atcaattgcc 78061 atgagaacac caggcttctc aggcgctgac ttagaaaacc tcttgaatga agctgcgctt 78121 gtagcggctc gtcaaaacaa gaaaaaaatc gatgcgcgtg atattgacga agcgacggac 78181 cgtgtaattg ccggacccgc taagaagagc cgcgttatct ccaagaaaga acgcaatatc 78241 gtggcttatc acgaaggcgg acacaccgtt atcggtctcg ttttagatga ggcagatatg 78301 gttcataaag taacgattgt tcctcggggc caggctggcg gttatgctgt tatgctgcca 78361 agagaagacc gttatttcca aacaaagccg gagctgcttg ataaaattgt cggcctcttg 78421 ggcggacgtg ttgctgaaga gattatcttc ggtgaagtca gcacaggggc gcacaatgac 78481 ttccagcgtg cgacgaatat tgcaagacga atggttacag aattcggtat gtcagaaaaa 78541 ctgggaccgt tgcaatttgg acagtctcag ggcggtcagg tattcttagg ccgtgatttc 78601 aacaacgaac agaactacag tgatcaaatc gcttacgaaa ttgatcagga aattcagcgc 78661 atcatcaaag aatgttatga gcgtgcgaaa caaatcctga ctgaaaatcg tgacaagctt 78721 gaattgattg cccaaacgct tctgaaagtt gaaacgcttg acgctgaaca aatcaaacac 78781 cttatcgatc atggaacatt acctgagcgt aatttctcag atgatgaaaa gaacgatgat 78841 gtgaaagtaa acattctgac aaaaacagaa gaaaagaaag acgatacgaa agagtaattc 78901 gctttctttc taaaaaaact gccggctgac gctggcagtt tttttatgta aatgattggc 78961 tcagctgcgg cttttacaat catccaattc tggtatcgat ttgtttacaa atgagccgct 79021 gatcgtgtat ggtattgtag aatgtttgta aaaagtaaag tagagaaact attcaaaagt 79081 ggtgatagag gttgttactg gttatcgatg tggggaacac caatactgta cttggtgtat 79141 atcatgatgg aaaattagaa tatcactggc gtatagaaac aagcaggcat aaaacagaag 79201 atgagtttgg gatgattttg cgctccttat ttgatcactc cgggcttatg tttgaacaga 79261 tagatggcat tattatttcg tcagtagtgc cgccaatcat gtttgcgtta gaaagaatgt 79321 gcacaaaata ctttcatatc gagcctcaaa ttgttggtcc aggtatgaaa accggtttaa 79381 atataaaata tgacaatccg aaagaagtag gggcagacag aatcgtaaat gctgtcgctg 79441 cgatacactt gtacggcaat ccattaattg ttgtcgattt cggaaccgcc acaacgtact 79501 gctatattga tgaaaacaaa caatacatgg gcggggcgat tgcccctggg attacaattt 79561 cgacagaggc gctttactcg cgtgcagcaa agcttcctcg tatcgaaatc acccggcccg 79621 acaatattat cggaaaaaac actgttagcg cgatgcaatc tggaatttta tttggctatg 79681 tcggccaagt ggaaggaatc gttaagcgaa tgaaatggca ggcaaaacag gaaccaaagg 79741 tcattgcgac aggaggcctg gcgccgctca ttgcgaacga atcagattgt atagacatcg 79801 ttgatccatt cttaacccta aaagggctgg aattgattta tgaaagaaac cgcgtaggaa 79861 gtgtatagga ggtttagtaa tggattattt agtaaaagca cttgcgtatg acggaaaagt 79921 tcgggcttat gcagcgagaa cgactgatat ggtaaatgag gggcagagac gccatggtac 79981 gtggccgaca gcatccgctg cactaggccg tacaatgaca gcttcactta tgctcggcgc 80041 tatgctgaag ggcgatgata agctgaccgt gaaaatcgag ggcggaggtc cgatcggagc 80101 tattgtagct gatgccaatg ccaaaggaga agtcagagcc tatgtctcta acccgcaagt 80161 tcattttgat ttaaatgaac aaggtaagct tgatgtcaga cgtgcggttg gaacaaacgg 80221 aacgttaagt gtcgtaaaag atttaggttt gcgcgagttc ttcacaggac aagtagaaat 80281 cgtttcagga gaattaggag atgattttac ttactatctt gtgtcatctg agcaggttcc 80341 ttcatcagtg ggcgtaggtg tgctcgtaaa tcctgacaat accattcttg cggcaggggg 80401 ctttattatt cagctgatgc cgggaacaga tgatgaaaca atcacaaaaa ttgaacagcg 80461 tctatctcaa gtagagccga tttctaagct catccaaaaa gggctgacac cagaagaaat 80521 tttagaagaa gtcctaggcg agaaacctga gattttggaa acgatgcctg tcagattcca 80581 ttgcccttgt tcaaaagaac ggttcgaaac agccatttta ggactaggca aaaaagaaat 80641 tcaagatatg atagaagaag atggacaagc cgaagcagta tgccattttt gtaatgaaaa 80701 gtacttattt acaaaagaag agctggaagg gcttcgtgac caaactaccc gctaagctct 80761 ttagcgggtt tttaatttga gaaaaggggc tgaaagcagg tttgaaatca agaacaatct 80821 ggaccattat tttaggggcg ctgttggttt gctgtattgc tgttgcatat acgctgacga 80881 aatcccaagc cggcgcatcg tcatccggtg agtctattgc gactatcgga ggcaagagtg 80941 tgacaagaga agaatggctg aaagaaatgg aagatcagta tggtaagtca acgcttgaag 81001 atatgatcaa tgtccgagtt gttgagcagc tggctaaaaa gaacaaactt aaaatatcca 81061 aaagcgaagt tgatcgtgag tttttgctga ttaaagcggt caataattcc ttttacgaag 81121 atgaacatac gacggagaaa gagtggaaag accaaattcg ttataatatc ctccttgagg 81181 atttgttaac aagggatatc gatatctcaa acaaagaatt ggaatcattc tataataaaa 81241 ataaggaact atatcagttt gatgattcgt atcgaattcg gcacattgtt gtaaaagatg 81301 aagaagaagc aagagaagtc ctgaaagaac tgaaaggcgg atcaagcttt gaagctgtcg 81361 ctgccgaaag atctacagac agatatacat caccatacgg cggagattta ggttttgtca 81421 cagaggcatc agacaacatt ccatcagcat acattgaaga ggcgaaaaca ctcaaagagg 81481 atgaatggtc tcaggaacca ataaaggtca gcaacggata tgccattatc cagctgaaag 81541 aaaaactaaa ggcaagaacg ttctcatttg atgaagtaaa ggaccagatc agacggcaaa 81601 tcgcaatgga tcagctaggc gataaagcga cagttaagac actttggaaa gaagccgatg 81661 tatcttggtt ttatggggaa aaaagtacta agtgattgac aaaaaatttt gaaattgata 81721 gattatatac ataataccaa tacaaatagt cggaaattga ggtgtcgaga atggtacgtg 81781 tagcaaactc cattactgaa ttaattggga atacgccaat cgttaaatta aatcgccttg 81841 cagatgaaaa cagtgcggat gtatatctaa aacttgaata catgaaccct ggaagcagtg 81901 taaaagaccg tatcggttta gctatgattg aagcggctga aaaagaagga aaattaaaag 81961 ccggtaatac aatcattgaa ccgacaagcg gaaatactgg aatcgggctt gcaatggttg 82021 ctgctgctaa aggattaaaa gccattttgg ttatgcctga tacaatgagc atggagcgcc 82081 gcaaccttct tcgcgcatat ggtgctgagc ttgtgctgac tcctggtgcg gaaggcatga 82141 aaggtgctat taagaaagct gaagagcttg ctgaaaagca cggatacttt gtgccgcagc 82201 agtttaacaa cccttctaac cccgaaattc accgccaaac aacgggtaaa gaaatcgttg 82261 agcaattcgg tgatgatcag cttgacgcat ttgtagccgg aatcggaacg ggcggaacga 82321 ttacgggagc gggcgaagtg ctgaaggaag catacccttc catcaagatt tatgctgttg 82381 aaccgtcaga ttccccagtg ctttcaggag gaaaaccagg cccccacaaa attcagggaa 82441 tcggagcagg attcgtgccg gacatcttaa acactgaagt atatgatgaa atcttccctg 82501 tgaagaatga agaagcattc gaatatgccc gcagagctgc acgtgaagaa ggaattctcg 82561 gaggcatctc atcaggtgcg gcaatttatg ctgctcttca agtagcaaaa aaactcggaa 82621 aaggcaaaaa agtattggcc atcattccaa gtaacggcga acgttatcta agcacgccgc 82681 tgtaccaatt cgattaaaaa aagccaaaac tcccggttcg ccgggagttt ttttatattt 82741 cgtgcatcaa atatgccatg tctgcgacga atgttattct tggaagagaa attcactttt 82801 ttcactaaca acattgcttt acaattaaaa acaagtaaaa aagaaaatag aggaatgata 82861 caaatggcac aacgcagacc ggcaggcaaa aaaatacctt ttcaaaaaga ctcattctta 82921 caacaatttg agaaacttgc gcaatcccgg aaacatcatg tacttctcga aagtgcaaga 82981 ggcggcagat atagtatagc cggtcttgat ccaattgcga ctgtgaaagg aaaagacgga 83041 ataactacaa ttaagcatgg tgatgagatg ctgtttaaag aaggtgatcc attacgggcc 83101 ttccacagct ggtttaaaac actggaaaca gaaacgaatc atgagttccc tgactttcaa 83161 ggcggggcaa tcgggtttct cagctatgat tacgcacggt acattgaaaa ttttaaaatg 83221 ctctcattag atgatttaga aacaccagat atttattttc ttgtttttga tgatatagca 83281 gtttatgacc atcaagaaga gtctctatgg ctgattactc atgttaatgg ttctgatcag 83341 gaaacagcgg atgtgaagct atctgagtta gagcagatgt ggttgactga gcttcccgct 83401 gtcacttcgc gagagatgaa gcctgaaaca gctggttctt tcgcggcgcc atttaccgag 83461 gatgggttct cacaagctgt agagaaaatc aaacaataca ttgccagcgg agatgtgttt 83521 caagtcaatc tatcaataag gcagtcacag tcactgtctg tccacccata tcaaatttac 83581 aaaaccttga gagaagtaaa tccttctcct tatatggcgt atttagaaac acctgatttc 83641 caaatcattt gcggatcgcc tgaactgctt gtcagcaaaa agggcaagct attagagacg 83701 agaccgattg cgggcacccg ttccagaggg aaaacaaatg aagaagacga ggcgcttgca 83761 aacgaattga tacacaatga aaaagaacgc gcggaacatg tcatgctggt tgatcttgag 83821 cgaaatgatc tgggaagagt atcacgttac gggtctgtgc gcgtaaatga attcatggca 83881 attgaaaaat actcgcatgt gatgcacatt gtgtctaatg tccaaggtga actgcaggat 83941 gggtatgatg ctgtagatat tattcatgct gtgtttcccg gaggaaccat tactggtgca 84001 ccgaaagtaa gaacgatgga aattatagaa gaacttgagc cgacacgccg agggctttat 84061 actggatcta taggatggtt tggatataat cacgatctgc agtttaatat cgtcattcga 84121 accatttatg caaccggagg gcaggcattt atgcagtccg gtgcaggagt tgtgattgat 84181 tctgttccga agcacgaata caaggaatca ttcaaaaaag cttttgcgat gcaaagagca 84241 ttagagctga gcgaagaaga gacaaaaatt agatgaggtg agcggagaaa tgattttaat 84301 gattgataac tacgattcat tcacgtacaa cttggtacag tatttgggcg agcttgggga 84361 agagctggtt gtgaaacgca atgacagcat cacaatcgat gaaattgaag aactgtctcc 84421 ggactttctg atgatatctc ccggaccgtg cagccctgat gaggcgggaa tcagcctcga 84481 agcaattaaa catttcgcag ggaaaattcc tattttcggt gtatgtctcg gacatcagtc 84541 catcgcacaa gtgttcggtg gtgatgttgt tagggcagaa cggcttatgc acgggaaaac 84601 ctcggatatc gagcatgacg gcaaaaccat ttttgaaggg ttgaaaaatc cccttgttgc 84661 gacgcgatac cactcgctga tcgtaaaacc tgagacgctg ccaagctgtt ttacagtaac 84721 agcacaaacg aaagaaggag aaatcatggc tattcgccac aatgacctcc cgatagaggg 84781 tgtgcaattt cacccagagt ctattatgac ctcctttggg aaagaaatgc tcagaaattt 84841 tattgagaca tatcgcaagg aagttattgc gtgatgatat atgtgaacgg ccggtatatg 84901 gaggagaaag atgcagttct ttctcctttt gaccatgggt ttttatatgg gatcggtgtt 84961 ttcgaaacct tcaggctcta cgaaggctgc ccgtttttgc ttgattggca tatagagagg 85021 cttgaacgcg cgcttaagga tctgcaaatc gaatatactg tttcaaagca tgagatcctt 85081 gagatgctgg acaagctgct taagctaaat gatatcaagg atggcaatgc ccgcgtcaga 85141 ctgaacatat cagcgggaat cagcgataaa ggctttgtcg cccagacgta cgataagccc 85201 accgttttat gctttgtgaa tcagctgaaa ccagaaagtc ttcctttgca aaaagaagga 85261 aaggttttat cgatacggag aaacactcca gagggatcgt tccggttaaa atctcatcat 85321 tatctaaata atatgtatgc gaaacgggaa attggaaatg atccgcgtgt cgagggaatt 85381 ttcttaacgg aggatggagc tgttgcagag ggtatcatat ctaatgtctt ctggagaaaa 85441 ggtcgctgta tctatacgcc atcgcttgat accggtattc tggacggcgt cacgagacgt 85501 tttatcatag aaaatgcaaa ggatatcggc ctggagctca aaacgggccg atatgagcta 85561 gaagctctct tgacagctga cgaagcgtgg atgacgaact cggttcttga aatcatcccg 85621 tttactaaaa tagaagaagt aaactatgga agccaaagcg gagaagcaac ctccgctctt 85681 caattgttat acaaaaaaga aataaagaac atgattcatg aaaagggagg aagagcatgg 85741 cgcagcacac aatagatcaa acacaagtaa tccacactaa gcccagcgct ttatcatata 85801 aagagaagac gctggtgatg ggaattttaa acgtaacgcc tgactctttc tcggacggcg 85861 gaaaatatga cagcttggac aaggcgctgc tgcacgcgaa agagatgatc gatgatggtg 85921 cccatatcat tgatattgga ggggaatcga caaggcctgg cgctgagtgc gtatctgagg 85981 atgaggagat gtccagagtc attccggtga ttgagcggat tacgaaagag cttggtgttc 86041 ctatttctgt agacacgtac aaggcttctg tcgcagatga agcagtgaaa gccggtgcat 86101 ccattatcaa tgatatttgg ggagccaaac atgatccgaa gatggcttcc gttgcagctg 86161 aacataatgt tccaattgta ctcatgcata accgccctga aagaaactac aatgacttat 86221 tgccggatat gctgtcggac ttaatggaga gtgtaaaaat tgctgttgag gccggagtag 86281 acgagaagaa cattattctt gatcctggta tcggtttcgc gaaaacctat cacgataact 86341 tggcagtgat gaacaaacta gagattttca gcggattggg atatccggtt cttctggcaa 86401 cctcccgaaa aagattcatc ggacgtgttc tggatcttcc gcctgaggag cgggctgagg 86461 gcacaggcgc gactgtgtgt ctcggcattc aaaaaggctg tgacattgtc agggtccatg 86521 atgtaaagca aattgccaga atggcgaaaa tgatggacgc gatgctgaat aagggagggg 86581 tgcaccatgg ataaagttta tgtagaaggt atggagtttt acggatatca cggtgtgttc 86641 acagaagaaa acaaacttgg ccagcggttt aaagtcgatt taaccgctga gctggattta 86701 agcaaagctg gacagacaga cgaccttgag caaacgatca actatgctga gctctatcac 86761 gtatgtaaag atatcgtgga aggggagcct gtgaaattgg tggaaacgct ggcggaacgt 86821 attgctggca ctgttctcgg aaaatttcag cctgttcagc aatgtacggt gaaagtgatt 86881 aagccagacc cgccaattcc cggacactat aaatcagtag caattgaaat tacgagaaaa 86941 aagtcatgaa caacatagct tatattgcac ttggatctaa tattggagat agagaaacgt 87001 atttaaggca agcagtggct ttactgcatc agcatgctgc ggtgacagtc actaaagtgt 87061 cgtctattta cgaaactgac ccggtcggat acgaagatca agctcaattt ttgaatatgg 87121 ctgttgaaat caagacatca ttgaaccctt ttgaactcct tgaactgacg cagcagatag 87181 aaaatgaatt aggcagaaca agggaagtaa gatgggggcc gcggacggca gaccttgaca 87241 ttttgttatt taatcgtgaa aatattgaaa cagagcaact aattgttccg catccgagaa 87301 tgtatgagcg tttgtttgtc cttgcgccgc ttgcggaaat ttgccagcag gttgaaaaag 87361 aggctacaag cgccgaaaca gaccaagaag gtgtaagagt atggaagcag aaatctgggg 87421 tagacgaatt cgtgcattca gaaagctgaa aggttatact caagaaggat ttgcaaaagc 87481 attaggtata tcagtttcta ttctcggcga aattgaacgc ggaaaccgat tgccgtctgc 87541 tgccatcatt caagatgcag cagatgtttt aaatataagt gcggacgaat tggcgccgcc 87601 agaaaaatag aacaaatgaa aggaggagaa aaattgttca aaatcggaga tattcaattg 87661 aaaaaccggg ttgtgctcgc acctatggct ggtgtctgca actctgcgtt cagattgact 87721 gtaaaggaat tcggagccgg attggtatgc gctgaaatgg tcagtgacaa agcgatcctt 87781 tacaacaatg caagaacaat gggtatgctt tatattgatg aacgtgagaa accactgagc 87841 cttcaaattt tcggaggaaa aaaggaaacc cttgtggaag cggcgaagtt tgtagaccaa 87901 aacacaactg ctgatatcat tgatattaac atgggatgtc ccgtgccgaa gattacaaaa 87961 tgcgatgcgg gagccaaatg gcttctcgat cctgataaga tttacgaaat ggtttctgca 88021 gtagtggatg ctgttaataa gccagttaca gtgaaaatga gaatgggctg ggatgaagac 88081 cacattttcg cagtgaaaaa tgcacaggct gtagaacgtg cgggcggtaa agcagtggcg 88141 cttcacggcc gtacgagagt gcagatgtac gaaggaacgg caaactggga tatcatcaaa 88201 gaagtaaaac aatcagtatc gattccggtt atcggaaacg gcgatgttaa gacaccgcag 88261 gatgctaagc gtatgctcga tgagacagga gtagacgggg tcatgatcgg acgcgctgca 88321 ttgggtaacc cgtggatgat ttaccgtacg gttcagtatc ttgaaacagg taaattaaaa 88381 gaagagccgc aagtacgcga aaaaatggcc gtatgcaaac tgcatcttga ccgcctgatt 88441 gacttaaaag gtgaaaacgt agcggtaaga gaaatgagaa agcacgctgc atggtatctg 88501 aaaggcgtga aaggcaatgc gaacgttcgt aatgaaatca atcattgcga gacgagagaa 88561 gagtttgtac agcttttaga tgcatttacg gttgaagttg aggcaaaaga gcttcaaaat 88621 gcaaaagtag gataatactc acctctattt gctgctcact gctagtttta cgctggcagt 88681 ttttctgctt ttttcatgaa acaatatctg taatggagtg ataacaatga gtcaagaaga 88741 gcataaccat gaagaattga atgatcagct gcaagtcaga cgcgataaaa tgaatcagct 88801 gagagataac ggcatcgatc cattcggcgc acgttttgaa agaactcatc agtctcaaga 88861 agttatttcg gcatatcaag atctaaccaa agaagagtta gaagaaaaag cgattgaagt 88921 tacaatcgca ggccgcatga tgacaaaacg cggcaaagga aaagccggct ttgcccatct 88981 tcaggattta gaaggccaaa tccaaatcta cgtaagaaaa gacagtgtcg gtgacgacca 89041 atatgaaatc ttcaagtctt ctgacctcgg tgatcttatc ggcgtaaccg gaaaagtctt 89101 caaaacaaat gtaggcgaat tgtctgttaa agcaacttcc tttgaattgc tgacaaaagc 89161 gcttcgtccg cttcctgaca aataccatgg tttaaaagac gttgagcagc gctaccgtca 89221 gcgctatctg gatcttatcg taaacccaga cagcaaacat acgttcatta cacgaagcaa 89281 gatcattcaa gctatgagaa ggtaccttga tgatcatgga tacttagaag tagaaacacc 89341 tacaatgcac agcattcctg ggggagcttc tgcacgtccg tttatcactc accacaacgc 89401 gttagacatt ccactctata tgcgtattgc tatcgaactg cacctaaaac gtctaattgt 89461 cggcggttta gaaaaagtat atgaaatcgg ccgtgttttc cgtaacgaag gtgtctctac 89521 acgccataac cctgaattta caatgattga gttatatgaa gcatatgcgg actataaaga 89581 tatcatgagc ttaactgaaa accttgtcgc tcatatcgcc caagaagtgc ttggcacaac 89641 tacgattcaa tacggggaag agcaaatcga ccttaaaccg gagtggaaaa gaatccatat 89701 ggttgacgca gtcaaagaag cgaccggcgt tgatttctgg gaagaggtta ctgttgagca 89761 ggcgcgtgaa tatgcaaaag aacatgaagt agaaattaaa gactctatga cagtaggcca 89821 tatcatcaac gaattcttcg aacaaaaaat tgaagaaacg cttattcagc caacgtttat 89881 ttacgggcat cctgtagaaa tttctcctct tgctaagaaa aaccctgagg acccgcgttt 89941 tacagaccgt tttgagctgt ttatcgttgg ccgtgaacat gccaacgcgt ttacagagct 90001 gaatgatcct attgatcaaa gagaacgctt tgaagcgcaa ttaaaagagc gtgaagccgg 90061 taatgatgaa gctcatttaa tggatgaaga ctttgttgaa gctctggaat acggtatgcc 90121 gccaacagga ggtttaggca tcggtatcga ccgtctggtt atgctgctga cgaatgcccc 90181 ttctattcgc gatgtgctgt tattcccgca aatgagacaa cgctaataaa aaagagcggt 90241 atcctccata gggaaaggat gccgctcttt ttaaatccct tagtatttct tcaaaaaaac 90301 tattgcacta ttatttacta ggtggtatat tattattcgt tgccgctaaa caaggcgata 90361 acgaaaaaaa gaacttcaaa aaaagttatt gacttcactg agtcaacgag ttataataat 90421 aaagtcgctt gaacgaagtg aacaaaatga tctttgaaaa ctaaacaaga caaaacgtac 90481 ctgttaattc agtttttaaa aatcgcacag cgatgtgcgt agtcagtcaa actactttat 90541 cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac atgcaagtcg 90601 agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt aacacgtggg 90661 taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg gatggttgtt 90721 tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttgcaga tggacccgcg 90781 gcgcattagc tagttggtga ggtaatggct caccaaggca acgatgcgta gccgacctga 90841 gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg aggcagcagt 90901 agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag tgatgaaggt 90961 tttcggatcg taaagctctg ttgttaggga agaacaagtg ccgttcgaat agggcggtac 91021 cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg cggtaatacg 91081 taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg gtttcttaag 91141 tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg gaacttgagt 91201 gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat gtggaggaac 91261 accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa agcgtgggga 91321 gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct aagtgttagg 91381 gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg ggagtacggt 91441 cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga gcatgtggtt 91501 taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca atcctagaga 91561 taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc agctcgtgtc 91621 gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt gccagcattc 91681 agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg atgacgtcaa 91741 atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga acaaagggca 91801 gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat cgcagtctgc 91861 aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc gcggtgaata 91921 cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac acccgaagtc 91981 ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg gggtgaagtc 92041 gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa ggatatttta 92101 cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt agttttgaag 92161 gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc acattcaagt 92221 aatacaagat atcacatagt gattcttttt aacggttaag ttagaaaggg cgcacggtgg 92281 atgccttggc actaggagcc gatgaaggac gggacgaaca ccgatatgct tcggggagct 92341 gtaagcaagc tttgatccgg agatttccga atggggaaac ccaccactcg taatggagtg 92401 gtatccatat ctgaattcat aggatatgag aaggcagacc cggggaactg aaacatctaa 92461 gtacccggag gaagagaaag caaatgcgat tccctgagta gcggcgagcg aaacgggatt 92521 agcccaaacc aagaggcttg cctcttgggg ttgtaggaca ctctgtacgg agttacaaag 92581 gaacgaggta gatgaagagg tctggaaagg cccgccatag gaggtaacag ccctgtagtc 92641 aaaacttcgt tctctcctga gtggatcctg agtacggcgg aacacgtgaa attccgtcgg 92701 aatccgggag gaccatctcc caaggctaaa tactccctag tgaccgatag tgaaccagta 92761 ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga aagagatcct gaaaccgtgt 92821 gcctacaagt agtcagagcc cgttaacggg tgatggcgtg ccttttgtag aatgaaccgg 92881 cgagttacga tcccgtgcaa ggttaagcag aagatgcgga gccgcagcga aagcgagtct 92941 gaatagggcg catgagtacg tggtcgtaga cccgaaacca ggtgatctac ccatgtccag 93001 ggtgaagttc aggtaacact gaatggaggc ccgaacccac gcacgttgaa aagtgcgggg 93061 atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga gatagctggt tctctccgaa 93121 atagctttag ggctagcctc aaggtaagag tcttggaggt agagcactga ttggactagg 93181 ggcccctacc gggttaccga attcagtcaa actccgaatg ccaatgactt atccttggga 93241 gtcagactgc gagtgataag atccgtagtc gaaagggaaa cagcccagac cgccagctaa 93301 ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt gcttagacaa ccaggatgtt 93361 ggcttagaag cagccaccat ttaaagagtg cgtaatagct cactggtcga gtgactctgc 93421 gccgaaaatg taccggggct aaacgtatca ccgaagctgc ggactgttct tcgaacagtg 93481 gtaggagagc gttctaaggg ctgtgaagcc agaccggaag gactggtgga gcgcttagaa 93541 gtgagaatgc cggtatgagt agcgaaagag gggtgagaat cccctccacc gaatgcctaa 93601 ggtttcctga ggaaggctcg tccgctcagg gttagtcggg acctaagccg aggccgaaag 93661 gcgtaggcga tggacaacag gttgatattc ctgtaccacc tcctcaccat ttgagcaatg 93721 gggggacgca ggaggatagg gtaagcgcgg tattggatat ccgcgtccaa gcagttaggc 93781 tgggaaatag gcaaatccgt ttcccataag gctgagctgt gatggcgagc gaaatatagt 93841 agcgaagttc ctgattccac actgccaaga aaagcctcta gcgaggtgag aggtgcccgt 93901 accgcaaacc gacacaggta ggcgaggaga gaatcctaag gtgatcgaga gaactctcgt 93961 taaggaactc ggcaaaatga ccccgtaact tcgggagaag gggtgctctg ttagggtgca 94021 agcccgagag agccgcagtg aataggccca ggcgactgtt tagcaaaaac acaggtctct 94081 gcgaagccgt aaggcgaagt ataggggctg acgcctgccc ggtgctggaa ggttaagagg 94141 agcgcttagc gtaagcgaag gtgcgaattg aagccccagt aaacggcggc cgtaactata 94201 acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc gacccgcacg aaaggcgcaa 94261 cgatctgggc actgtctcaa cgagagactc ggtgaaatta tagtacctgt gaagatgcag 94321 gttacccgcg acaggacgga aagaccccgt ggagctttac tgcagcctga tattgaatgt 94381 tggtacagct tgtacaggat aggtaggagc cttggaaacc ggagcgccag cttcggtgga 94441 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 94501 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 94561 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 94621 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 94681 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 94741 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 94801 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 94861 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 94921 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 94981 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 95041 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 95101 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 95161 atcgatcgag gacttaacca tatttttgaa tgatgtcaca tctgttatct agttttgaga 95221 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 95281 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 95341 acgccgccaa gcaattgcac gttagtgcaa ttatggagga ttagctcagc tgggagagca 95401 tctgccttac aagcagaggg tcggcggttc gagcccgtca tcctccacca ttatgccggt 95461 gtagctcaat tggtagagca actgacttgt aatcagtagg ttgggggttc aagtcctctt 95521 gccggcacca cttttatatg atataatact caagtctctt gtagaagagc cattagctca 95581 gttggtagag catctgactt ttaatcagag ggtcgaaggt tcgagtcctt catggctcac 95641 cattttacgc gggtgtggcg gaattggcag acgcgctaga cttaggatct agtgtcttta 95701 tgacgtgggg gttcaagtcc cttcacccgc attatatagg ataacagtta gaaaaactgg 95761 acatcctgtc tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 95821 gggttcgaat cccgtcttcc gctccaacta taccatccac gccggggtgg tggaattggc 95881 agacacacag gacttaaaat cctgcggtag gtgactaccg tgccggttca agtccggccc 95941 tcggcattat gttttgcgcc cgtagctcaa ttggatagag cgtttgacta cggatcaaaa 96001 ggttaggggt tcgactcctc tcgggcgcgc catatctttt aatagaatag ataggaaatc 96061 gggaagtagc tcagcttggt agagcacatg gtttgggacc atggggtcgc aggttcgaat 96121 cctgtcttcc cgaccatttt tttatggggc cttagctcag ctgggagagc gcctgctttg 96181 cacgcaggag gtcagcggtt cgatcccgct aggctccacc aaaagttttt aaaaaagttg 96241 ttgactttga agaagtgacg ttgtatacta ataaagttgc tttaacaaag cggacaaaca 96301 aaatgatctt tgaaaactaa acaagacaaa acgtacctgt taattcagtt tttaaaaatc 96361 gcacagcgat gtgcgtagtc agtcaaacta ctttatcgga gagtttgatc ctggctcagg 96421 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc 96481 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 96541 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 96601 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 96661 acggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 96721 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 96781 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 96841 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 96901 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 96961 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 97021 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 97081 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 97141 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 97201 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 97261 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 97321 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 97381 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 97441 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 97501 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 97561 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 97621 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 97681 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 97741 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 97801 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 97861 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 97921 gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc ttgggtctta 97981 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 98041 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 98101 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 98161 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 98221 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 98281 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 98341 tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga ggcttgcctc 98401 ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg aagaggtctg 98461 gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc tcctgagtgg 98521 atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc atctcccaag 98581 gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg tgaaaagcac 98641 cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc agagcccgtt 98701 aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc gtgcaaggtt 98761 aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg agtacgtggt 98821 cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt aacactgaat 98881 ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta ggggtgaaat 98941 gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct agcctcaagg 99001 taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt taccgaattc 99061 agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt gataagatcc 99121 gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata cgttaagtgg 99181 aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc caccatttaa 99241 agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc ggggctaaac 99301 gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc taagggctgt 99361 gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt atgagtagcg 99421 aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa ggctcgtccg 99481 ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga caacaggttg 99541 atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag gatagggtaa 99601 gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa atccgtttcc 99661 cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga ttccacactg 99721 ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca caggtaggcg 99781 aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca aaatgacccc 99841 gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc gcagtgaata 99901 ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg cgaagtatag 99961 gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa gcgaaggtgc 100021 gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta gcgaaattcc 100081 ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg tctcaacgag 100141 agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag gacggaaaga 100201 ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta caggataggt 100261 aggagccttg gaaaccggag cgccagcttt ggtggaggca tcggtgggat actaccctgg 100321 ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc aggtgggcag 100381 tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt ccctcagaat 100441 ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga gacctacaag 100501 tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa gggccatcgc 100561 tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag tccacatcga 100621 cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag tcggtcccaa 100681 gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg tcgtgagaca 100741 gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct tagtacgaga 100801 ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat cgctgggtag 100861 ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc tcaagatgag 100921 atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat aggtctgagg 100981 tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact taaccatatt 101041 tttgaatgat gtcacatctg ttatctagtt ttgagagaac actctcaatt tgtttggtgg 101101 cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc tcttcagcgc 101161 cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa gcttaaaccc 101221 agctcaatga gctgggtttt ttgtattttg gtttattggt atcataaaat tccacttaac 101281 tgtataatat aataacttta taccgaattt taaatcagca atcaggtttt gtggaccggg 101341 aaaatggaaa taatgaagga tagagcgaga aagttgaaaa ttctcgagaa acggcttata 101401 gtaagattaa agtcaaatat agtcaaagtc agtaaaggag ggggttgagt gggacataat 101461 atttctgaca tcattgaaca atatttaaaa cgagtgttag atcaaaatgg caaggaaatt 101521 ttagagatta aacgaagtga aattgcagat aaatttcaat gcgttccttc ccaaataaat 101581 tatgtcatca acaccagatt tacaagcgaa agaggatata ttgttgagag caaacgcggg 101641 ggcggcggtt acatcagaat cattaaaatt aaaatgaaca atgaagttgt cctgatcaat 101701 aatataattt ctcaaattaa tacccatttg tctcaagcag cctctgatga cattatttta 101761 aggctattag aagacaaggt aatttcagaa agagaagcaa aaatgatggt cagcgtaatg 101821 gaccgctcag ttttacacat tgacttacct gaacgtgatg aattaagagc gagaatgatg 101881 aaggcaatgc tgacttcttt aaaattaaaa taagcgggtg aaaagattga tttgtcaaga 101941 gtgccacgag agaccagcca cttttcactt tacaaaggtt gttaacggag aaaaaataga 102001 agttcatatt tgtgaacaat gtgccaaaga aaatagtgat tcatatggta taagtgcaaa 102061 tcagggtttc tctattcata atttactttc gggtttactg aacatggatt cttcatttca 102121 aaatgcagga actcaaatgt tcagtcactc ggagcaaata tctgcttgtc cgaaatgcgg 102181 aatgactttt cagcaattca gaaaaattgg ccgttttgga tgttctgaat gttacaaaac 102241 atttcatagc aacattacac caatcctacg taaagtgcac agcggaaaca ctgtgcatgc 102301 aggtaagata ccgaaacgaa taggcggcaa tcttcatgtc agacggcaga ttgatatgct 102361 aaaaaaggaa ttagaatcct taatccatca agaagaattt gaaaatgcag ctcatgtaag 102421 agatcaaatt cgtttattag aacaatcact caaaagtaca gatagtgagg aggaacagga 102481 gtaatgtcgc taaagcattt tattcaggac gcactaagca gttggatgaa gcagaaagga 102541 cctgaaagtg acattgtact cagcagccgc atacgtttag caagaaactt tgagcatatt 102601 cggttcccta cgcggtattc caatgaagaa gcctcatcca tcatacagca atttgaagat 102661 cagttttcag agcaagaaat tcccggaatc ggcaaatttg ttttgattag aatgaatgat 102721 gcacagcctt tagaaaagcg tgtacttgtt gaaaaacatc taatcagccc gaatttgaca 102781 gagtctcctt ttggcggctg tttgctttct gaaaatgagg aagtaagcgt catgctaaat 102841 gaagaggacc atattagaat tcagtgtctt ttccctggat ttcagctttt agaagcaatg 102901 aaagccgcaa accaggtcga cgactggatt gaagaaaaag ttgattatgc attcaatgag 102961 caaagaggat acttaaccag ctgtcctaca aacgtaggta ctggtttaag ggcttcggtc 103021 atgatgcatc tgccggcgct ggttttaact aggcaaataa atcgaattat accggcaatt 103081 aatcaattag gcttagttgt tagaggaatt tatggggaag gcagcgaagc agtagggaat 103141 atctttcaaa tttcaaatca gatcacgctt ggtaagtcag agcaggatat tgtagaggat 103201 cttaacagtg ttgctgctca gttgattgaa caagaacgat ctgcccgaga agcgatttat 103261 caaacttcta aaatcgaact tgaggatcgg gtatatcggt catatggggt cttgtctaat 103321 tgccggatga tagaatcgaa agaaactgca aagtgccttt cagatgttcg gttaggcata 103381 gacttaggca taataaaagg actttcaagc aacatactta acgaacttat gattttgacg 103441 cagccagggt ttttacagca atactcggga ggcgctttgc gaccgaacga aagggacatt 103501 cgaagagcgg ctctcatcag agaacggctt cacttagaaa tgaatgggaa aagacaggag 103561 gatgaatcga tatgatgttt ggaagattta cagaacgagc tcaaaaagta ctggcgctag 103621 cacaggaaga agcacttcgg ttaggtcata ataacattgg cactgagcat attttattag 103681 gactggtaag agaaggagag ggcattgctg ctaaagctct tcaagcgctt ggactcggtt 103741 cagaaaaaat tcagaaagaa gtagaaagtt tgatcgggcg cgggcaggaa atgtctcaaa 103801 cgattcatta tactcctaga gctaaaaaag tcattgagct ttcaatggat gaggcaagaa 103861 aactcggtca ttcttatgtg ggaacagaac atattcttct tggtctgatt cgtgaaggag 103921 aaggtgttgc tgcgagagtt ctgaataatc tcggtgtcag cttaaataaa gcaagacagc 103981 aggtgctcca gcttctagga agtaatgaaa caggatcatc agcggcagga acaaacagca 104041 atgcgaatac gcctacgctt gacagcttgg caagagactt aactgctatt gcgaaggaag 104101 acagccttga ccctgtaatc ggcagaagca aggagatcca gcgtgtcatt gaagtgttaa 104161 gccgcagaac gaaaaacaac cctgttctca ttggggaacc aggtgtaggt aaaacggcta 104221 tcgcagaagg tttggcacag caaattatca ataatgaagt acccgaaatt ttgcgtgata 104281 aacgtgtgat gacattagac atgggaacag ttgttgccgg cacaaaatac cgcggagaat 104341 ttgaggatcg cctgaagaag gtcatggatg aaattcgcca ggcaggaaat atcattctat 104401 tcatcgatga gctccataca ttaatcgggg caggcggagc agaaggtgct attgatgcat 104461 ctaatatttt aaaaccttca cttgctcgtg gcgaactcca atgtattggt gcaacgactc 104521 ttgatgagta ccgtaaatat attgaaaaag atgcagcact ggaacgccgt tttcagccga 104581 ttcaggttga tcagccatct gtagatgaaa gtattcaaat tttacaaggt ctgcgtgaca 104641 gatacgaagc ccaccaccgc gtttctatca ctgatgatgc cattgaagct gcggttaagc 104701 tttctgacag atatatttct gaccgcttcc ttccggataa agcaattgac ttgatcgatg 104761 aagcgggttc aaaggtgaga ctgcgctcat ttacaacgcc tcctaactta aaagagcttg 104821 agcagaagct tgatgaggtt cgtaaagaga aggatgcggc agtgcaaagc caagagtttg 104881 aaaaagctgc ttccttgcgt gatactgaac aacgcctgcg cgagcaagta gaggatacga 104941 agaaatcatg gaaagagaag caagggcagg aaaactcaga ggttactgtg gatgatattg 105001 cgatggttgt atccagctgg accggtgtgc ctgtatctaa aatcgcccaa actgaaactg 105061 ataagcttct caatatggaa aacattcttc actcccgtgt catcggccag gatgaagcag 105121 ttgtagcggt tgcaaaagcc gtcagacgtg caagagcagg attgaaagat cctaaacgcc 105181 caatcggctc attcattttc ttaggcccta caggtgtagg taaaacagaa cttgcacgag 105241 cacttgctga atccattttt ggcgatgaag aatccatgat cagaattgat atgtctgaat 105301 acatggaaaa acattcaact tcaagacttg ttggttcacc tccgggttat gtgggatatg 105361 atgaaggcgg tcaattgaca gagaaagtca gaagaaaacc ttactctgtc gtgcttcttg 105421 atgagatcga gaaagcgcac cctgatgtct tcaatatcct tctgcaagtt cttgaagacg 105481 gacgattgac tgattctaaa ggacgcacag tcgatttccg caataccatt ctgatcatga 105541 catcaaacgt cggagcaagt gagctaaaac gcaataaata tgtcggcttt aacgttcagg 105601 atgaaactca aaatcataaa gacatgaaag ataaagtgat gggtgaatta aaacgagcgt 105661 tcagacctga gttcatcaac cgtattgatg aaatcattgt cttccattca cttgagaaaa 105721 aacatctcac tgagattgtg tcattaatgt ctgatcaatt aacgaaacgc ctgaaagaac 105781 aagatctttc tatcgaattg acagatgctg caaaagcgaa agtcgcggaa gagggcgttg 105841 acctggaata cggtgcccgt ccgttaagaa gagcgatcca aaaacatgtc gaggatcgtt 105901 tatctgaaga actcctcaga ggaaatattc ataaaggaca gcatattgtt cttgatgtag 105961 aagatggcga atttgtcgta aaaacgactg ctaaaacgaa ttaatataga agacggaaat 106021 gaggcataca gcatgtaagt gtatgcctca ctttcatatc aagaaataga acaagggaga 106081 ggtcttacac tatatatggc taaaacaaaa tcgaagttca tctgccaatc ctgcggctac 106141 gagtctccaa aatggatggg gaaatgtccg ggctgtggtg cttggaatac aatggtggaa 106201 gaaatgatta aaaaagcacc ggccaatcgg agagcggctt tttctcattc tgttcaaact 106261 gtacagaaac cttcacctat tacatcaatc gaaacatcag aagaaccccg cgtcaaaacc 106321 cagcttggcg agtttaacag agtactcggc ggaggtgtcg ttaaaggctc cctcgtttta 106381 attggcggtg atcctggtat cggaaagtca acgctattac tgcaggtttc cgctcaatta 106441 tcaggctcat caaacagtgt cctgtatatt tcgggagaag aatctgtaaa gcaaacgaag 106501 ctgcgagcag accgtctcgg cattaataat ccgtcactgc atgttttatc tgaaaccgat 106561 atggagtata tttcgtctgc tatacaagag atgaatccat cgtttgtcgt tgttgactct 106621 attcaaacgg tttaccaaag cgatattaca tctgctccag gcagtgtgtc acaggtcaga 106681 gaatgtaccg ctgagctgat gaaaattgca aaaacaaaag gtattccgat ttttatcgta 106741 gggcacgtga cgaaagaagg gtctattgca ggtccgagac tgttggagca tatggttgac 106801 actgttttat attttgaagg agaacgccac catactttcc gtattttgcg ggctgtaaaa 106861 aaccgtttcg gatctacaaa cgaaatgggc attttcgaaa tgcgggaaga ggggctcact 106921 gaggttttga atccttcgga aattttctta gaagaacgct ctgctggttc cgcaggctcg 106981 agtatcactg cctctatgga gggcactaga ccgattctcg ttgaaattca ggcactcatc 107041 tcgccaacaa gttttggcaa cccaaggcgt atggcaacgg gaatagacca taacagggtt 107101 tctctgttaa tggctgtgtt agaaaaaaga gttggactgc tgctgcaaaa tcaggatgct 107161 tatttgaaag tggctggcgg cgttaagctt gatgaaccgg caattgatct tgcgattgtg 107221 attagtattg catcaagctt tagagacaca cctccaaatc ctgcagattg ttttattgga 107281 gaagtgggat taaccggaga agtccggcgg gtttcaagaa ttgaacagcg tgtgaaagaa 107341 gcggcaaagc ttggttttaa acgcatgatc atacccgcgg caaatctgga tggatggaca 107401 aaaccaaaag ggattgaggt tatcggagta gcaaatgttg cagaagcgct tcgtacttca 107461 ttaggaggat aatagatgga aaaagagaaa aaaggggcga aacacgagtt agacctgtca 107521 tctatattgc agtttgttgc tccgggtaca ccgctcagag cggggatgga aaacgtcttg 107581 agagcaaata caggcggtct gattgttgtt ggatataatg ataaagtaaa agaagtggtg 107641 gacggcggct ttcacataaa cacggctttt tctccggcgc atttatatga gctggctaaa 107701 atggatggag cgatcatttt aagtgattct ggtcaaaaga tcctatacgc gaatactcag 107761 ctgatgccgg atgccacaat ttcttcatca gaaacaggaa tgcggcacag aactgccgaa 107821 agagtagcta agcaaactgg ctgtcttgta atcgccattt ctgaaagaag aaatgtcata 107881 acgttatatc aggaaaacat gaagtataca ctaaaagaca taggatttat tttaaccaag 107941 gcgaaccaag ccattcaaac acttgaaaaa tataagacaa tcctcgataa aacgattaat 108001 gcactgaacg cgttagagtt tgaggaactt gttaccttca gtgatgtctt gtctgtcatg 108061 catcgttatg aaatggtact gagaatcaaa aacgaaatta atatgtatat caaagagctg 108121 gggacagaag ggcatctgat caaactgcaa gtcattgaat tgattacgga tatggaagaa 108181 gaggccgctt tatttattaa ggactatgta aaagaaaaga ttaaagatcc gtttgttctc 108241 ttgaaggagc tgcaggatat gtccagttat gatctgctgg atgattccat tgtgtataag 108301 cttctcggtt accctgcttc tactaatctt gatgattatg tattgccgag aggatacagg 108361 ctgttaaata agataccgcg tcttccgatg ccgattgttg aaaatgttgt agaagcattt 108421 ggagtcctgc caaggattat tgaggcgagt gcagaagaat tagatgaagt agagggaatc 108481 ggtgaagtac gagcccaaaa aatcaaaaaa ggattaaaac gcctgcaaga gaagcattat 108541 ttagacagac aactgtgatt tcggttaaaa ccttatgaat acgggtatat taatgttggt 108601 ttttgtttat tctgatattc gtaggatgca taagactttg tgaaattaaa atgttaaaaa 108661 aggaggtggg ggtatgttaa aacgaatagt tcaggcgttc ttcattattt ttggcggcgt 108721 tgttggtata tttttgatac ctgaattgtt tgtactgtta aatatacagg acataccttt 108781 aataacaaac gcatatacgt ctgcggcaat aggagcaatt atcttttttc tcatcagtat 108841 atggggtaca gaatacgttg tgaactgggt gaagtggata gaggattcat tgttaaaagc 108901 gccggttcca gatttgttat ttggaagtct tggcttagtt tttggactta taattgctta 108961 tcttatcgta aatgttattc ctttagacaa tataccttac cgcatattca gcacaataat 109021 tcctgtattt ttggctttct tcctcggtta tctcggcttc caggtgggct ttaagaaaaa 109081 ggatgaattg atcagcctgt tttccatttc cgccagaatg caaaagaaaa aaggaacagc 109141 tgatgaagaa catgaggttc aagacaagaa gctgaaaatt ttggacacta gtgttattat 109201 tgatgggaga atagcagata tttgtcagac tggtttttta gagggagtta tcgtgattcc 109261 gcagtttgtc cttgaggaat tgcagcatat tgcagactct tcagatgttt taaaacgaaa 109321 cagaggacgc cgcggtcttg atatcctgaa ccgcattcag aaagaattag acattgaagt 109381 tgaaatttac gaaggcgact ttgaagatat tcaggaggtt gacagcaagc tcgtcaaact 109441 tgctaagctg acatccgggg tcgttgtgac gaatgatttt aatttaaata aagtgtgcga 109501 gcttcagaag gtagcagtat taaacattaa tgaccttgcc aatgcggtta agcctgttgt 109561 gcttcctggc gaggaaatga atgttcaggt cattaaggac gggaaagagc ataatcaggg 109621 agttgcctac ttggatgacg gtacgatgat tgtcgttgaa gaaggacgga attatatcgg 109681 caagcatatt gatgtactcg tcacaagtgt gctgcagaca gcagcgggac gaatgatttt 109741 tgcgaagcct aagctgttgg agaaggcgct gtaaagggag aagaaacaat gagttatgat 109801 gtggtgattc ctgcagccgg acagggaaag cggatgaagg cagggagaaa taaactgttc 109861 attgagctga agggagaccc ggtgatcata cacacgttaa gagtgtttga cagccaccgg 109921 cagtgcgata aaatcatttt ggtgattaac gagcaggagc gggagcactt tcagcaattg 109981 ctgtccgatt acccgtttca aacttcaatt gagcttgttg caggcggaga tgagcgacag 110041 cacagtgtgt ataaggggct gaaagccgta aagcaggaaa agattgtcct tgtacatgac 110101 ggtgcccgtc catttataaa acatgaacaa attgacgaac tgatcgcaga ggcggaacag 110161 acaggagcgg ccatccttgc tgttccggta aaagatacga ttaaacgcgt tcaagattta 110221 caagtcagtg agacgattga acgttcaagc ttgtgggctg tccaaacgcc acaagctttt 110281 cgtctttctt tattgatgaa ggctcacgct gaggccgagc gcaagggatt tttagggacg 110341 gatgacgcca gcctcgttga acagatggag ggcggttcgg tccgtgttgt agaaggcagc 110401 tatacaaata ttaagctgac gacgccagac gatttgacgt cagctgaagc tatcatggaa 110461 tcagaaagtg ggaataaaca tgtttagaat tggacaagga tttgatgtgc atcaattagt 110521 ggagggccgt cctctcatta ttggcggaat tgaaatcccg tacgaaaaag ggctgcttgg 110581 ccattctgat gcagacgtat tgttgcatac cgtcgctgac gcctgcctgg gagctgtggg 110641 tgaaggagac ataggcaagc attttcctga cacagatccc gagttcaagg acgcagattc 110701 tttcaaatta cttcagcatg tctggggaat cgtgaaacag aaggggtatg tccttgggaa 110761 cattgattgc accatcatag cgcaaaagcc gaagatgctg ccgtacatag aagatatgag 110821 aaaaagaatt gctgaaggcc ttgaggcaga tgtttctcaa gtaaatgtaa aagcaacaac 110881 gacagaaaag cttggattta caggccgggc ggaaggaata gcggctcagg cgacagtact 110941 gatacaaaaa ggctaacttg ttttgatgcc gggtctattt ggtggtagaa tagattcata 111001 catttttgcc tgaggccata catgacatga aaggaagtat ttgaaaatgg gaaacgaagt 111061 acgcgtccgt tatgcaccga gtccaaccgg acatttgcat attggaaatg ccagaacggc 111121 gctttttaat tatttatttg cccgcaatca aggcggtaag tttatcattc gagttgagga 111181 tactgataaa aagcgcaata ttgagggcgg agaacaaagc cagctgaatt atctgaagtg 111241 gctaggtatt gactgggatg agagtgtgga tgtcggagga gagtacggtc cataccgtca 111301 gtcagagcgt aacgatatct ataaagtgta ctatgaagag cttcttgaaa aagggcttgc 111361 ttataaatgt tactgtacgg aagaagagct tgaaaaagag cgtgaagaac agattgcccg 111421 cggagaaatg cctcgttatt ccggaaaaca cagagacctg actcaggaag aacaggagaa 111481 atttatcgcc gaaggcagaa aaccaagtat tcgtttccgt gtgccggaag gaaaagtcat 111541 cgccttcaac gacatcgtaa aaggcgaaat ttcttttgaa tcagatggca tcggcgactt 111601 cgttattgtg aaaaaggacg gaacgcctac ttataacttc gcggtagcta ttgatgacta 111661 cttaatgaaa atgacacacg tgctgcgcgg tgaggatcat atttctaaca caccgaaaca 111721 gattatgatc tatcaagcat tcgggtggga tattcctcag ttcggacaca tgacgctgat 111781 tgtaaacgaa agccgtaaaa agctcagcaa acgtgatgaa tccattattc aattcatcga 111841 gcagtacaaa gagcttggct acctgccaga agcgctgttc aactttatcg gcttgttagg 111901 ctggtcaccg gttggagaag aagagctttt cacaaaagag cagtttattg aaatttttga 111961 tgtaaatcgt ttatctaaat caccagcttt gtttgatatg cataagctaa aatgggttaa 112021 caaccaatat gtgaagaagc tggatcttga tcaggttgtt gaactgacgc ttccgcattt 112081 gcaaaaagcc ggcaaagttg gcactgagct ttctgctgaa gaacaagaat gggttcgtaa 112141 actgatttcc ctgtatcatg agcaattaag ctacggtgcg gaaattgttg agctgactga 112201 tttgttcttt acggatgaga tcgagtataa tcaagaagcg aaagctgttc tggaagaaga 112261 acaggttcct gaagtgctca gcacattcgc agcgaagctt gaagagcttg aggagttcac 112321 tccggataat atcaaagcat cgatcaaagc agtgcagaaa gaaactggcc ataaagggaa 112381 aaaactgttt atgccgattc gtgttgctgt aacagggcaa actcacggtc cggaactgcc 112441 gcaatcaatt gaattgatcg gtaaagagac tgcaattcag cgtttaaaga atatctaaat 112501 aaatgattgt tgacagggaa gagtataaag ctttaggcca ttacagaaag gatcttcatt 112561 ggctgagaga gatccatgag ccgggtttta gaagtgcgcc cttaagacct ttgaagaacg 112621 ttttttgaaa tcagtattca aaggcggccg ccgccgttac aggctgaagt tgggagagca 112681 gaagtctgct tttcaaacag agtggaaccg cgcggttaaa gcgtctctgt catgtttaca 112741 tgcagagacg ctttttttat tgggtagagg aaatcagata gagaaacggg gggaagcatg 112801 tgttttttag aatgctcaaa gaagacattg atactgtgtt cgatcaagat cccgcagcaa 112861 gaagctattt tgaagtgatt ttaacttatt ccggtttaca tgctatatgg gcgcatcgga 112921 ttgcacatgc tttatataaa cgaaaatttt atttccttgc acgccttata tctcaagtaa 112981 gccgattttt taccgggata gaaatccacc ccggcgctac aatcgggaga agatttttca 113041 tagaccacgg catgggggtt gtcattgggg agacatgtga aatcggcaat aacgtaaccg 113101 tttttcaggg ggttaccctc gggggaacgg gaaaagaaaa gggaaaaagg cacccaacga 113161 ttaaagatga cgcattgata gccacaggtg ctaaagtgct cggttctatt acggtcggtg 113221 aaggctcaaa gattggcgct ggttcagtag tgctgcatga tgttcctgat ttttcaacag 113281 ttgtcggtat ccctggacgg gtcgttgtac aaaatggcaa gaaagtaaga cgcgatttaa 113341 accatcagga tttgcccgat ccagttgctg accgctttaa gtctttggaa cagcagattt 113401 tagagctgaa ggcagaactt gaagacagaa aagaaaggat caatcaaaaa tgacaatcac 113461 actttataat acattgacta gacagaagga aacattcgtt cctcttgaag agggaaaagt 113521 gaaaatgtat gtatgcggac ccacggttta caattacatt catatcggga acgcgcgtcc 113581 ggcaatcgtt tacgatacgg ttcgaaacta tttagagtat aaaggctatg atgtgcagta 113641 tgtctctaac ttcacagacg tagacgataa attaattaaa gcggcaaatg aactcggtga 113701 ggatgtaccc accatttcag agcgttttat taaagcatac tttgaagacg taggtgcgct 113761 cggctgccga aaagccgacc ttcatccgcg agtaatggag aacatggatg ccattatcga 113821 attcgtagat cagctcgtga aaaagggcta cgcatatgaa tcagaaggtg acgtatattt 113881 caaaaccaga gcatttgaag ggtacggaaa gctttctcag caatcaatcg atgaactaag 113941 atcaggtgca cgcatccggg tcggcgagaa aaaagaagat gctcttgatt tcgcactgtg 114001 gaaagcggca aaagaaggag aaatctcttg ggatagccct tgggggaaag ggcgtccggg 114061 ctggcacatt gaatgctcag caatggtgaa aaagtatctc ggtgaccaga ttgatatcca 114121 tgcgggcgga caggatttaa cattccctca ccatgaaaac gaaattgcgc aatctgaggc 114181 gctgacaggc aaaacgtttg cgaagtactg gcttcataat ggttatatca atattgataa 114241 tgaaaaaatg tcaaaatcac taggcaactt tgtgcttgtg catgacatca ttaaacagca 114301 tgatccgcag cttttgagat tctttatgct atctgttcat tatcgccatc cgattaacta 114361 ttcagaagag cttctggaga atacgaaaag cgcgttcagc cgtttaaaaa cagcgtacag 114421 caatcttcag caccgtctga acagcagtac gaatttaacc gaagatgacg atcaatggct 114481 tgaaaaggtt gaagaacacc gcaaagcatt cgaagaagag atggacgatg attttaatac 114541 ggcgaatgcc atttcagtct tgtttgactt agcgaaacac gccaattatt atcttcagaa 114601 agatcatacg gctgatcatg tgattacggc gtttattgag atgtttgacc gcattgtttc 114661 tgtcctcggt ttttcgttgg gtgagcagga acttctcgat caagagattg aagacttaat 114721 cgaaaagcga aatgaagcgc gccggaatcg cgattttgca ttgtcagacc agatccgcga 114781 ccagctgaaa agcatgaata tcattcttga agatacggct caaggcactc gctggaaacg 114841 gggagaataa cagatgcttg aatttgatac gataaaagat tctaagcagc ttaacggtct 114901 tgcgcttgct tatataggtg atgccatttt tgaagtgtat gtcaggcatc acctgcttaa 114961 gcagggcttt accaaaccaa atgatcttca taagaaatca agccggattg tttcagcaaa 115021 gtcacaggct gagatcctat tttttctgca gaatcaatca ttttttacgg aagaagagga 115081 agcggtgctg aaaagaggca gaaatgccaa gtcagggaca acacctaaaa atacagatgt 115141 tcagacgtac cgctacagta cagcatttga agcgcttctg ggctaccttt ttctagagaa 115201 aaaagaggaa cgacttagtc agctcgtagc cgaagctata caattcggga cgtcagggag 115261 gaaaacaaat gagtcagcaa catgattacg tcatagggaa aaatgcagtg atcgagacgt 115321 taaaatctga tcggaagctg tataagctgt ggatggcgga aaacaccgta aagggacaag 115381 cacagcaagt gattgagctt gccaaaaagc agggaatcac gattcaatac gtcccgagaa 115441 aaaaactcga tcaaatggtg acaggacagc atcagggcgt agtggcacag gttgcagcgt 115501 atgaatatgc agaactggac gatttatata aagcagccga agaaaaaaat gaacagcctt 115561 tcttcctcat tctggacgag cttgaagacc ctcataatct tggttccatt atgaggacag 115621 cagatgcggt cggcgctcat ggcatcgtca ttccaaaacg gagagctgtc gggctgacaa 115681 caacagtggc aaaagcttca acaggagcaa ttgagcacat tcctgtagca agagtcacca 115741 atttggcacg gacgttagaa gagatgaaag agcggggaat ctgggttgtc ggaacggatg 115801 cgtccgcgcg tgaggatttc cgtaatatgg acggcaatat gcctttggct ctagtcatcg 115861 gaagtgaagg aaaagggatg ggccgccttg tgaaggaaaa gtgcgatttt ctcattaaac 115921 tcccgatggc cggaaaggta acttcactaa atgcatctgt cgcggctggt cttttgatgt 115981 atgaagtcta ccggaaacga aaccctgtgg gagaataaag acccatggat atcctgttag 116041 tagacgggta caacatgatt ggagcctggc cgcagctgaa ggatttaaaa gcgaacagtt 116101 ttgaagaggc gagagacgta ctgattcaga aaatggcgga atatcaatcg tatacaggaa 116161 acagggttat tgttgttttt gacgcgcatc tcgtaaaagg gcttgagaaa aaacagacca 116221 accatagagt tgaagtaatt tttacaaaag aaaatgagac ggctgatgag cggatagaaa 116281 agctcgctca ggctttgaat aatattgcga ctcaaattca cgttgcgacc tctgactata 116341 ctgagcagtg ggcgattttc ggacaggggg cattgcggaa atcggcccgg gagcttctga 116401 gagaggtaga aacgattgaa aggcgaatag agagacgggt aagaaaaatc acttccgaaa 116461 agccggcggg taaaattgct ttatcggaag aggttttgaa aacgtttgaa aagtggaggc 116521 ggggagactt agattaagtt gacgcttttt tgcccaatac tgtataatat ttctatctac 116581 gtgcgccggg gggatcggag tgaatctaca gaacaacaag ggaaaattca acaaagagca 116641 gttttgccag ttggaggacg agcaggtcat tgaaaaggtt catgttgggg acagtgatgc 116701 gttagattac ttgattacga agtaccgaaa ctttgttcgg gcaaaagcaa gatcctattt 116761 cttaataggg gcggacagag aggatattgt tcaggaaggc atgataggcc tctataagtc 116821 tattcgtgac ttcaaagagg acaagcttac ctcattcaaa gcttttgcag aattatgtat 116881 tacccgccaa attattaccg caataaagac agctactcgc cagaaacaca ttcctttgaa 116941 ttcctacgcc tcattagata aaccgatctt tgatgaagaa tcagaccgaa cgctgctgga 117001 tgtcatttca ggagcgaaaa ccttaaatcc tgaggaaatg atcattaatc aggaagaatt 117061 tgatgatatt gaaatgaaaa tgggagaact attaagtgat ttagagagaa aagtactcgt 117121 cttatatctc gacgggagaa gttaccaaga gatttctgat gaactgaacc gacatgtgaa 117181 atcgatcgac aatgcccttc agcgtgtgaa acgcaagctg gagaagtact tggaaattcg 117241 cgaaatcagt ttgtaatagg aatttatgct atattgacag tatttttctg actatgatat 117301 gttactaaag ataagaacta atgtctattt agaaaaaggt gtaatgacat gagaaaaaag 117361 attacgttag catgcaagac atgcggaaac cgtaattata cgacaatgaa gagctctgca 117421 tcagcggctg agcgattaga agtaaagaaa tactgcagta cttgcaattc acatacagct 117481 catcttgaaa caaaatagtt tttgcgcttt taaattgtgg aggtctttta catgcgtatt 117541 atgaaattct ttaaagatgt tgggaaagaa atgaaaaagg taagctggcc taaaggaaaa 117601 gagttaacgc gttataccat tacggtaatt tcaacagtta tcttttttgt tatctttttt 117661 gccctccttg acacaggaat ttctcaatta attcgtttaa tagttgaata atgatcagca 117721 atacgtgcta taatagatca taatattact tgccaaaacc cgttcagcgg gttttttatt 117781 gtggcttaaa atgaaagtta tcataggctt gccgcctatt ttttgaagcg ttatggtaat 117841 tcactaaaac caaatgcggg gagggaagga ctggacagtc ctgaatagaa tggaaaagaa 117901 ttggtatgtt gttcacacgt actctggtta tgagaataaa gtaaaagcca acttggaaaa 117961 gcgtgttgaa tcaatgggga tgcaggataa aattttccgt gtagtcgtac ccgaagaaga 118021 agaaacggat atcaaaaacg gcaagaaaaa agtcgtgaaa aagaaagtat tccctggtta 118081 tgtgcttgtt gaaattgtaa tgacagacga ctcttggtat gtcgtccgca acacgccggg 118141 cgttactgga ttcgtaggat ctgccgggtc aggttcaaaa ccgacgccgc ttcttccggg 118201 ggaagcagaa accattctga agagaatggg catggatgaa cgaaaaactg atattgactt 118261 tgaactgaaa gagacagtga aagtaataga cggacctttt gctaacttta caggatcaat 118321 tgaagagatt gattatgata aaagcaaggt caaagttttc gttaatatgt ttggccgtga 118381 aacgccggtt gagctggaat ttacccaaat cgataaattg taatgtgaaa aaacttgaaa 118441 ttgctatata taaatgataa tatagcaaag gtacgtcttg gacttatcca aggcaactag 118501 catgatattt cgtcattcat ataaagaatg aaaccttgag tgggagggtt taccctatta 118561 ccacatcacg gacttaagga ggtgtgtctc gtggctaaaa aagtagttaa agttgtaaaa 118621 ttgcaaattc ctgctggaaa agctaaccca gcaccaccag ttggacctgc acttggtcaa 118681 gccggtgtta acatcatggg attctgtaag gagtttaacg ctcgtacagc tgaccaagct 118741 ggtttaatca ttcctgttga aatttcggtt tacgaagacc gttcatttac atttattaca 118801 aaaactccac ctgctgcagt attgcttaaa aaagcagctg gaattgagtc tggttctggt 118861 gaaccaaacc gtaataaagt ggcaaccgtt aagcgcgata aagtacgcga aatcgctgaa 118921 acgaaaatgc ctgacttaaa cgcagcagac gttgaagcgg caatgcgcat ggttgaaggt 118981 actgcccgca gtatgggtat tgtaatcgag gattaatttg tttcttgtcg ggttgcgagt 119041 tttaacaagt tcgcaaccct tattcgtggg aggttattcc gctataacca cataaggagg 119101 aaattttaaa atggctaaaa aaggtaaaaa gtacgttgaa gctgctaagc ttgtagaccg 119161 ttctaaagct tacgacgtct ctgaagcagt agctctcgtt aaaaaaacaa acacagctaa 119221 attcgacgct acagttgaag tggctttccg tttaggggtt gaccctcgta aaaacgacca 119281 gcaaatccgt ggagcagttg tgcttccaaa cggaactggt aaaactcagc gcgttctcgt 119341 tttcgcaaaa ggcgaaaaag cgaaagaagc tgaagctgct ggtgcagatt tcgtaggcga 119401 tactgactac atcaacaaaa ttcaacaagg ctggttcgat ttcgatgtta tcgtagctac 119461 acctgacatg atgggtgaag ttggtaaaat cggtcgtgta cttggaccaa aaggtttaat 119521 gccgaaccct aaaactggta cagttacttt cgaagttgaa aaagctatcg gcgaaatcaa 119581 agctggtaaa gttgaatacc gcgttgataa agctggaaac attcatgttc ctatcggtaa 119641 agtttctttc gaggatgaaa aacttgttga gaacttcaca acaatgtacg atacaatcct 119701 taaagctaaa cctgctgcag ctaaaggcgt ttacgtgaaa aacgttgctg taacttctac 119761 tatgggacct ggtgtcaaag tagactcttc aacttttaac gtaaaataat attgacatga 119821 catcaacatt ctgatattat tcaaaatgtt gtaaaataga atatcattta taccgtagac 119881 agtaggggcc taaccgctta attatcctac cgaggtgtat attatcacag ctattacgtt 119941 acgtatgctt gtatatacag cctccatgtc tcatggaggc tttttatatg gaatccgtcg 120001 tctcagtcgt gatcacctaa cggtataagt gttacacaag aatctacagg aggtgtaacc 120061 atgagcagcg caattgaaac aaaaaaagtt gttgttgaag aaattgcttc taaactgaaa 120121 gaaagtaaat caacgatcat cgttgactat cgcggactta acgtttctga agtaactgaa 120181 cttcgtaaac agcttcgcga agctaacgtt gagttcaaag tttacaaaaa tacgatgact 120241 cgccgtgcgg ttgaacaagc tgagcttaat ggtttgaatg atttcttaac tggaccgaac 120301 gcgatcgcat tcagcactga agatgttgtc gctccggcta aagttcttaa tgacttcgct 120361 aaaaatcacg aagctcttga aatcaaagct ggcgttatcg aaggtaaagt ttctactgtt 120421 gaagaagtga aagctcttgc tgaacttcca tcacgcgaag gcttgctttc tatgttgctt 120481 agcgtacttc aagctccagt tcgcaacctt gctcttgctg caaaagctgt ggcagaacaa 120541 aaggaagaac aaggcgctta atctaatcag tttttcataa attaaaacaa aatggaggaa 120601 ttacaaatgg ctttaaatat cgaagaaatc attgcttccg ttaaagaagc aactgtactt 120661 gaattgaacg acctagtaaa agcaatcgaa gaagaatttg gcgtaactgc tgctgctcct 120721 gtagctgtag ctggcggagc tgctgctggc ggagctgctg aagagcaaag cgaattcgat 120781 cttatccttg ctggtgcagg atctcaaaaa atcaaagtta tcaaagttgt acgtgaaatc 120841 actggtcttg gcttgaaaga agctaaagag cttgttgaca acactccaaa accacttaaa 120901 gaaggtattg ctaaagaaga agctgaagag cttaaagcta aacttgaaga agttggcgct 120961 tctgtagaag ttaagtaatc ttcacttacc tgtaggggaa gctcgctttt atgaggcgag 121021 ctttttcttt gccattcttt aagccatgaa aaaaggaggt tctaataatg agtgagcact 121081 attattcaga aaaaccttca gtaaaaagca acaagcaaac ctggtctttt aggcttcgga 121141 ataaagattt cacgtttacc agcgacagcg gggttttttc taaaaaagaa gttgatttcg 121201 gctcccgcct gctgattgat tcttttgaag agcctgaggt tgagggcggc attttagatg 121261 taggctgcgg atacggcccg attggtttat cgctcgccag cgactttaaa gaccggacca 121321 tccacatgat tgacgttaat gagagagccg tagaactatc aaatgaaaat gcggaacaga 121381 acggaataac aaacgttaag atttatcaaa gcgatttgtt ttcaaacgtt gattctgctc 121441 aaacatttgc ttctattctt acaaatcccc caatccgagc cggaaaaaaa gttgtccatg 121501 ctatctttga gaaaagcgct gaacacttaa aagcttcagg tgaattgtgg atcgtcatac 121561 agaaaaagca aggcgcgcct tctgccattg aaaagctcga ggaactgttc gatgaagttt 121621 ccgtcgttca aaaaaagaaa ggctattata tcataaaagc aaaaaaagtt tgactcggta 121681 ttttaactat gttaatattg taaaatgcca atgtatatat tttgcttgat atgatgaatt 121741 gtcaatatct atgtataaat tatacaagta tggaaatgct aataaaatcg gtatttgttt 121801 ttggatgtgg ttttcttaat tagaaaccct tttttctttt gtcttgtaaa agtattttct 121861 ttctttggaa gaaatgctta ttacacatat aatacgcatg atttgagggg tgaatcagtt 121921 gacaggtcaa ctagttcagt atggacgaca ccgccagcgc agaagctatg ctcgcattag 121981 cgaagtgtta gaattaccaa atctcattga aattcaaacc tcttcttatc agtggtttct 122041 tgatgagggt cttagagaga tgtttcaaga catatcacca attgaggatt tcactggtaa 122101 cctctctctt gagttcattg attatagttt aggtgagcct aaatatcctg tagaggaatc 122161 aaaagaacgt gatgtgactt actcagctcc gctaagagtg aaggttcgtt taattaacaa 122221 agaaactgga gaggtaaaag accaagatgt cttcatgggt gatttcccta ttatgacaga 122281 tacaggtact tttatcatta acggtgcgga acgtgttatc gtttcccagc ttgttcggtc 122341 tccaagtgta tatttcagtg gtaaagtaga caaaaacggt aaaaaaggtt ttaccgcaac 122401 tgtcattcca aaccgtggcg catggttaga atacgaaact gatgcgaaag atgttgttta 122461 tgtccgcatt gatcgcacac gtaagttgcc ggttacggtt cttttgcgtg ctctcggctt 122521 cggctccgat caagagattc ttgatctcat aggagaaaac gaatacctgc gaaatacgct 122581 tgataaagat aacacagaaa acagcgacaa agcgttgctg gaaatttacg agcgtctccg 122641 tcctggagag ccgcctacag tagaaaatgc gaaaagcttg cttgattctc gtttctttga 122701 tccgaaacga tacgatcttg ccaatgtagg acgctataaa attaataaaa aacttcatat 122761 taagaatcgc ctcttcaatc agagacttgc tgaaacgctt gttgatcctg aaacaggaga 122821 aatccttgct gaaaaaggcc agattcttga tagaagaacg cttgataaag tactgccata 122881 cttagaaaac ggaatcggtt ttagaaagct gtatccgaat ggcggcgttg ttgaagatga 122941 agtgactctt caatcaatta aaatctttgc tccgactgat caagaaggag aacaggttat 123001 caatgtaatc ggcaatgctt acatcgaaga agagattaaa aacatcacgc ctgctgatat 123061 tatttcttca atcagctact tcttcaacct gctgcacgga gtaggcgaca cagatgatat 123121 cgatcatctt ggaaaccgcc gtttacgttc tgtaggcgag cttctccaga accaattccg 123181 tatcggttta agccgtatgg agcgtgtggt tcgtgagaga atgtcaattc aagatacgaa 123241 tacaattacg cctcagcagc tgatcaatat tcgtcctgtt attgcgtcca ttaaagagtt 123301 ctttggaagc tcacagcttt ctcaattcat ggatcagacg aacccgcttg ctgaattaac 123361 gcacaagcgt cgtctgtcag cattaggacc gggcggattg acacgtgagc gtgccggaat 123421 ggaagtgcgt gacgttcact actcccacta tggccgtatg tgtccgattg aaacgcctga 123481 gggcccgaac atcggtttga tcaactcact atcatcttat gcaaaagtaa accgttttgg 123541 ctttattgaa acgccatatc gccgcgttga ccctgaaaca gggaaggtaa cgggcagaat 123601 cgattactta actgctgatg aagaggataa ctatgttgtc gctcaagcga atgctcgtct 123661 tgatgacgaa ggcgccttta ttgatgacag catcgtagct cgtttccgcg gggagaacac 123721 cgttgtttcc agaaatcgtg tagactacat ggatgtatcg cctaagcagg ttgtatctgc 123781 tgcgacagca tgtatcccgt tcttagaaaa cgatgactcc aaccgtgccc tcatgggagc 123841 gaacatgcag cgtcaggctg tgcctttgat gcagccggaa gcgccatttg ttggaactgg 123901 tatggaatac gtatcaggaa aagactctgg tgccgctgtt atttgtaaac accctggtat 123961 cgttgaacgc gtagaagcca aaaacgtttg ggttcgccgt tatgaagaag tagacggtca 124021 aaaagtaaaa ggaaacctgg ataaatacag cctgctgaaa tttgtccgct ctaaccaagg 124081 tacgtgctac aaccagcgtc cgatcgtaag tgtcggcgat gaagtggtaa aaggagaaat 124141 ccttgctgac ggtccttcta tggagcttgg tgaacttgca cttggccgta acgtaatggt 124201 cggcttcatg acgtgggatg gctacaacta tgaggatgcc atcatcatga gtgaacgcct 124261 agtgaaggat gatgtttata catctatcca cattgaagaa tacgaatcag aagcacgtga 124321 tacgaaactt ggacctgaag aaatcactcg cgatattcca aacgtcggtg aagatgcgct 124381 tcgcaatctt gatgaccgcg gaatcatccg tattggggca gaagtaaaag acggagatct 124441 tcttgttggt aaagtaacgc ctaaaggcgt aactgaactg actgccgaag aacgccttct 124501 tcacgccatc tttggcgaga aagcccgcga ggttcgtgat acttctcttc gtgtgcctca 124561 tggcggcggc ggaattatcc atgacgttaa agtcttcaac cgtgaagacg gagacgaact 124621 tcctccaggt gttaaccagt tagtacgcgt atatatcgtt cagaaacgta agatttctga 124681 aggggataaa atggccggtc gtcacggtaa caaaggtgtt atctctaaga ttcttcctga 124741 agaggatatg ccttaccttc ctgacggcac accaattgat atcatgctta acccgctggg 124801 cgtaccatca cgtatgaaca tcgggcaggt attggaactt cacatgggta tggccgctcg 124861 ttaccttggc attcacattg catctcctgt atttgacgga gcgcgagaag aggatgtctg 124921 ggaaacactt gaagaagccg gcatgtctcg tgacgccaaa acagtgcttt acgacggacg 124981 tactggagag ccgtttgata accgtgtatc tgtcggtatc atgtacatga tcaaactggc 125041 tcacatggtt gacgataaac ttcatgcacg ctctacaggc ccttactcac ttgttacgca 125101 gcagcctctt ggcggtaaag cgcaatttgg cggacagcgt tttggtgaga tggaggtttg 125161 ggcacttgaa gcttacggtg cggcttacac tcttcaagaa attctgactg ttaagtctga 125221 tgacgtggtt ggacgtgtga aaacatacga agccatcgtt aaaggcgaca atgttcctga 125281 accaggtgtt ccggaatcat tcaaagtatt aatcaaagaa cttcaaagct taggtatgga 125341 tgtcaaaatc ctttctggtg atgaagaaga aatagaaatg agagatttag aagacgaaga 125401 agatgcgaaa caagctgacg gcctggcatt atcaggtgat gaagagccgg aagaaacagc 125461 atctgcagac gttgaacgcg atgtagtaac aaaagaataa tctctagtta taaaggcaag 125521 tgacatcggt taatccgaag ataaaaaggg aggtaggccc cttgctagat gtgaacaatt 125581 ttgagtatat gaacatcggt cttgcttcac cagataaaat ccgttcatgg tcttttggtg 125641 aagtgaaaaa gcctgaaacg ataaactatc gtacgttaaa acctgaaaag gacggtctat 125701 tctgcgaacg cattttcgga ccgactaagg actgggaatg tcattgcggg aagtacaagc 125761 gagttcgtta taaaggcgta gtttgtgacc gctgcggagt cgaagtaaca cgggctaaag 125821 tccgtcgtga gagaatgggg cacattgaac tggctgcccc agtttcccac atttggtatt 125881 tcaaaggtat tccaagccgt atgggtcttg tgctggatat gtcacctcgt gctttagaag 125941 aagtcattta ctttgcttct tacgttgtaa ctgatccggc gaatacaccg cttgaaaaga 126001 aacagcttct gtctgagaaa gaataccgtg cttatcttga taaatacggt aataaattcc 126061 aagcatctat gggtgctgaa gcaattcata aacttcttca agatatcgat cttgtaaaag 126121 aagttgatat gttaaaagaa gagctgaaaa cttcacaagg acaacgccgt actcgtgcga 126181 tcaaacgtct tgaagtttta gaagccttcc gtaactcagg aaacaagcct tcttggatga 126241 tccttgatgt gcttcctgtt attcctccgg agcttagacc gatggttcag ctagatggcg 126301 gacgttttgc gacttctgat ttgaatgacc tttatcgtcg tgtcatcaac cgtaacaatc 126361 gtttgaaacg ccttttggac cttggtgcgc ctagcatcat cgttcaaaac gaaaagcgta 126421 tgcttcaaga ggctgtcgat gccctaattg acaacggccg ccgcggacgc cctgtaacag 126481 gtcctggaaa cagaccgtta aaatctcttt ctcacatgct gaaagggaag caaggccgtt 126541 tccgtcaaaa ccttcttggt aaacgtgtcg attactccgg acgttctgta atcgttgttg 126601 gtcctcattt gaaaatgtac caatgcggat taccgaagga aatggcactt gaacttttca 126661 aacctttcgt tatgaaagaa cttgttgaaa aaggtcttgc tcacaacatt aagagtgcga 126721 aacgcaaaat tgagcgcgta cagcctgaag tttgggatgt actagaatca gttattaagg 126781 agcatccggt actgctgaac cgtgccccta cacttcacag attaggtatc caggcgtttg 126841 aaccaacgct tgttgaagga cgcgcaatcc gtcttcaccc gctcgtatgt acagcttaca 126901 acgctgactt tgacggtgac caaatggcgg ttcacgtacc attatctgct gaagcacaag 126961 ctgaagcacg catcttgatg cttgctgctc aaaacatctt gaaccctaaa gatggtaaac 127021 cggttgtaac accgtctcag gatatggtac taggtaacta ttacctgaca cttgagcgtg 127081 ccggtgctgt cggtgaaggt atggtcttca agaatacaga cgaagcgctt cttgcttatc 127141 aaaacggata tgttcacctt catacgagag tagctgttgc agctaactca cttaagaatg 127201 tgacatttac cgaagaacag cgctcaaaat tgttaattac aactgtcggt aagcttgtct 127261 tcaatgaaat tcttccggaa tcattccctt acatgaatga accaacgaag agcaacattg 127321 aagagaaaac acctgaccgt ttcttcttag aaaaaggtgc tgatgttaaa gctgttatcg 127381 cacagcagcc aatcaatgcg ccgtttaaaa aaggcattct gggtaaaatc atcgcggaaa 127441 tctttaaacg attccatatt acggaaacgt ctaaaatgct tgaccgcatg aaaaacctag 127501 gtttcaaata ttcaactaaa gctggtatta cagttggggt ttctgacatc gtcgtactcg 127561 atgataaaca agaaattctt gaggaagcgc aaagcaaagt tgacaacgtt atgaagcaat 127621 tccgccgcgg tcttatcact gaagaagaac gctatgagag agtcatctct atctggagtg 127681 ctgcaaaaga cgttatccaa ggcaaactga tgaaatcact tgatgaactc aacccgatct 127741 acatgatgag tgactctggt gcccgtggta acgcatctaa ctttacgcag cttgccggaa 127801 tgcgcggcct gatggccaac ccggctggac gtatcattga gttgccgatc aaatcaagtt 127861 tccgtgaagg tctgacagta ttggagtact ttatctccac acacggtgcg cgtaaaggtc 127921 ttgccgatac cgctcttaaa actgctgact caggttacct tacacgccgt ctcgttgacg 127981 ttgctcagga tgttatcatc cgtgaaactg attgcggaac tgaccgaggc attcttgcta 128041 agcctcttaa agaaggaact gaaacaattg agcgcttaga agaacgctta atcggacgtt 128101 ttgcaagaaa acaagtgaag caccctgaaa caggtgaagt gcttgtgaat gaaaacgaac 128161 tgatcgatga agataaagca ctggagattg tcgaagccgg cattgaagaa gtgtggatcc 128221 gttctgcctt cacatgtaat acgcctcatg gtgtatgtaa acgatgctat ggccgaaatc 128281 ttgcaactgg ctccgatgtt gaagtcggtg aagctgtcgg aatcattgct gcccaatcaa 128341 tcggtgagcc tggtacacag ttaacaatgc gtacattcca tacaggcggg gttgccggag 128401 acgatatcac acagggtctt ccgcgtatcc aagagctttt cgaagcgcgt aatccgaaag 128461 gtcaggcaac aattacagaa atcgacggta cagtcgttga gatcaatgaa gttcgtgata 128521 agcaacagga aattgtggtt caaggcgcag tggaaacacg ttcttatacg gcaccttaca 128581 actcccgcct gaaagtagcg gaaggagata aaattactcg aggccaagta ctgacagaag 128641 gttcaatcga tccgaaagaa cttcttaaag tgactgacct gacgactgtt caagagtatc 128701 ttctccatga ggttcaaaag gtttaccgta tgcagggtgt tgaaatcggt gataaacacg 128761 tagaagtaat ggttcgccag atgcttcgca aagtacgcgt gattgatgcc ggtgacactg 128821 atgtgcttcc aggtacattg cttgatattc accaatttac tgaagcgaac aaaaaggtat 128881 tgcttgaagg caaccgacca gctacaggcc gtcctgtctt actcggtatt acaaaagcat 128941 ctcttgaaac tgattcattc ttatctgctg cttccttcca ggaaacaaca cgtgtcctta 129001 cagatgcagc gatcaaaggt aagcgtgacg agcttctcgg cttgaaagag aatgttatca 129061 tcggtaagct tgttccagca ggtacaggaa tgatgaaata ccgtaaagta aaaccagtat 129121 caaatgttca gccgactgac gatatggtcc cggttgaata actgatttaa ctctgctgaa 129181 agactgcaaa aacagtcttt cagcagatat atttatgaaa aagtcactct atgagaagaa 129241 cgaatctaaa aaatgtcata ccttgttgac attcgtctcc tagaatgata atataaccaa 129301 ggtgctcgaa ataaacctgt tactttggag gatatgttta tgtcttatga taaagtatca 129361 caggccaaat caattattat tggtacgaag caaacagtga aagctctaaa gcgaggttca 129421 gtaaaggaag tagtcgttgc aaaagacgca gatccgatac tcacgtcaag tgttgtttca 129481 cttgctgaag atcaaggtat ctctgtctca atggttgaat ccatgaaaaa gctcggcaaa 129541 gcctgcggaa ttgaggtagg agcagccgct gttgccatta ttttataacg tacttttgtt 129601 tttgcgtaag attccatctt gtgtaaagac attgtttttt gccttttgat gaaccacctg 129661 ggtatgtggg ttataaaacg taatgaaggg aggaaaaatt catgcctaca attaatcagc 129721 taattcgcaa aggacgcgtg agtaaagtag aaaactcaaa gtctcctgca cttaacaaag 129781 gatacaacag ctttaaaaaa gagcacacta acgtatcttc tccacaaaaa cgcggggtat 129841 gtactcgtgt tggtacaatg acaccgaaaa aaccgaactc agcacttcgt aaatatgctc 129901 gtgttcgttt gactaacgga atcgaggtta ctgcttacat tcctggtatc ggtcacaacc 129961 tgcaagagca cagtgttgta cttatccgcg gcggacgtgt aaaagactta ccaggggtac 130021 gttaccacat cgttcgtggt gcgcttgata ctgctggagt tgaaaaccgt gcacaaggcc 130081 gttctaaata cggtacgaaa aaacctaaag caaaataata tacgaaaata cgcataattg 130141 atgaagggag gatattcaga tgccacgtaa aggtcctgta gcaaaaagag atgttttacc 130201 tgatccgatt tacaactcta agcttgtatc tcgtttaatc aacaaaatga tgatcgatgg 130261 taaaaaaggt aagtctcaaa cgatcctata caagtcattc gatatcatta aagaacgtac 130321 tggcaatgat gcaatggagg ttttcgaaca agcattgaaa aacatcatgc ctgtacttga 130381 agtaaaagca cgccgtgtag gtggtgcgaa ctaccaagtt cctgtagaag ttcgtcctga 130441 acgtcgtacg actcttggac ttcgctggtt agttaactac gctcgtcttc gtggagaaaa 130501 aacgatggaa gagcgtttag ctaacgaaat ccttgacgca gctaacaaca ctggtgctgc 130561 tgttaagaaa cgtgaagaca ctcataagat ggctgaagca aacaaagcat ttgctcacta 130621 tcgctggtag gatttataga ttaacaaaac acaatttcct aataaggaag gagaaattac 130681 ccaatggcaa gagagttctc cttagaaaaa actcgtaata tcggtatcat ggctcacatc 130741 gatgccggta aaacgactac tacagaacgt atcttgttct atactggtcg tatccacaaa 130801 attggtgaaa ctcatgaagg agcttcacaa atggactgga tggagcagga acaagaacgt 130861 ggtatcacaa tcacttccgc tgcgactact gcacagtgga aaggataccg cgtaaacatc 130921 atcgatactc caggacacgt agacttcaca gttgaagttg aacgttctct tcgtgtactt 130981 gatggtgctg ttgctgtact tgacgcgcaa tcaggcgttg agcctcaaac agaaactgtt 131041 tggcgtcagg caacaactta tggagtaccg cgtatcgttt ttgttaacaa aatggacaaa 131101 atcggtgcag acttccttta ctctgtagga actttaagag accgtcttca agcaaacgct 131161 catgcaattc aattgccgat cggtgctgaa gataacttcg aaggtatcat tgaccttgta 131221 gaaaacgttg cgtatttcta cgaagatgac ctcggaactc gttctgatgc aaaagaaatc 131281 cctgaagagt acaaagagca agctgaagag cttcgcaaca gccttattga agctgtatgt 131341 gagcttgatg aagagcttat ggataagtac cttgagggtg aagaaatcac aattgacgag 131401 ttaaaagcag gaattcgtaa aggtacatta aatgttgaat tctaccctgt tcttgttggt 131461 tctgccttca aaaacaaagg tgttcaacta gtacttgatg ctgttcttga ctaccttcct 131521 gcaccaactg acgttgctgc aatcaaaggt acacgtcctg atacaaatga agagattgag 131581 cgtcattctt ctgacgaaga gccattctct gcattagcat ttaaagttat gactgaccct 131641 tacgttggta agttgacgtt cttccgtgtg tactctggaa cacttgattc tggttcatac 131701 gtgaaaaact ctactaaagg caaacgtgag cgtgttggac gtattcttca aatgcacgct 131761 aacagccgtg aagaaatctc tactgtatac gcaggggata tcgcagctgc tgtaggtcta 131821 aaagatacaa ctactggaga tactctatgt gatgagaagg atcttgttat ccttgagtca 131881 atggaattcc cagaaccagt tatcgacgtt gctattgagc ctaaatcaaa agctgaccaa 131941 gataaaatgg gtatcgcttt agcgaaactt gctgaagaag atcctacatt ccgtactcaa 132001 acaaacccag aaactggcca aacgatcatc tctggtatgg gtgaacttca ccttgatatc 132061 attgttgacc gtatgaaacg cgaatttaaa gtagaagcca atgttggtgc tcctcaagtt 132121 gcgtaccgtg aaacattccg taccggtgca aaagttgaag gtaaattcgt acgtcagtct 132181 ggtggacgcg gtcagttcgg acacgtttgg atcgaattcg aaccaaacga agaaggcgct 132241 ggctttgaat ttgaaaatgc gattgtcggt ggggtcgttc ctcgtgaata catcccagct 132301 gttcaagcag gtctggaaga tgcactcgaa aatggtgtac tagcaggctt cccgcttatc 132361 gacattaaag ctaaactttt cgacggttct taccatgatg ttgactcaaa cgaaatggca 132421 tttaaagtcg ctgcttctat ggcattgaaa aatgcagtca gcaaatgtaa cccagttctt 132481 cttgaaccaa tcatgaaagt ggaagtggtt attccagaag aatatatggg agatatcatg 132541 ggtgatatca cttcacgtcg cggacgcgta gaaggtatgg aagcacgcgg taacgctcaa 132601 gttgttcgtg ctatggttcc tcttgctgaa atgttcggtt acgctactgc acttcgttct 132661 aatacgcaag gtcgcggtac gttcactatg cacatggatc actacgaaga agtgccgaag 132721 agcgtcgcag aagaaattat caaaaaaaat aaaggcgaat aattgatttt gccgcttaac 132781 tcaagtataa ctactattgt aagatgagga agtgaaagct ttctttcact tcctatcact 132841 ctatacatta ctaattaaaa gctcttaagg aggattttag aatggctaaa gaaaaattcg 132901 accgttccaa atcacatgcc aatattggta caattggaca cgttgaccat ggtaaaacaa 132961 ctttaactgc tgctatcaca acagtacttc ataagaaatc tggtaaaggt acagctatgg 133021 cgtacgatca aattgatggt gctccagaag aacgcgagcg cggtatcaca atctctactg 133081 cacacgttga gtacgaaact gaaactcgtc actatgcaca cgttgactgc ccaggacacg 133141 ctgactatgt taaaaacatg atcactggtg ctgcgcaaat ggacggagct atccttgtag 133201 tatctgctgc tgatggccca atgccacaaa ctcgtgagca catccttctt tctaaaaacg 133261 ttggtgtacc atacatcgtt gtattcttaa acaaatgcga catggtagac gacgaagagc 133321 ttcttgaact agttgaaatg gaagttcgcg atcttcttag cgaatacgac ttccctggtg 133381 atgatgtacc agttgttaaa ggttctgctc ttaaagctct tgaaggagac gctgagtggg 133441 aagctaaaat cttcgaactt atggatgcgg ttgatgagta catcccaact ccagaacgcg 133501 acactgaaaa accattcatg atgccagttg aggacgtatt ctcaatcact ggtcgtggta 133561 cagttgctac tggccgtgta gaacgcggac aagttaaagt cggtgacgaa gttgaaatca 133621 tcggtcttca agaagagaac aagaaaacaa ctgttacagg tgttgaaatg ttccgtaagc 133681 ttcttgatta cgctgaagct ggtgacaaca ttggtgccct tcttcgcggt gtatctcgtg 133741 aagaaatcca acgtggtcaa gtacttgcta aaccaggtac aatcactcca cacagcaaat 133801 tcaaagctga agtttacgtt ctttctaaag aagagggtgg acgtcatact ccattcttct 133861 ctaactaccg tcctcagttc tacttccgta caactgacgt aactggtatc atccatcttc 133921 cagaaggcgt agaaatggtt atgcctggag ataacactga aatgaacgtt gaacttattt 133981 ctacaatcgc tatcgaagaa ggaactcgtt tctctattcg tgaaggcgga cgtactgttg 134041 gttcaggcgt tgtttctaca atcactgagt aatagtatgg ttttaaacga gacccctgtg 134101 ggtctcgttt tttgtttgct tatctttttc ttgtataata ggatctatca tattcgaggg 134161 gttaatattt atgattcctg aaaagaaatc aatcgcaatc atgaaagaac taagcattgg 134221 aaatacaaag caaatgctga tgattaatgg agttgacgtg aaaaatccat tgctgctttt 134281 tttacatggc gggccgggaa cgccgcaaat cggatatgtt agacattatc aaaaagagct 134341 ggaacagtat tttacagtag ttcattggga tcagagagga tcggggcttt cttattctaa 134401 gcgaatttcg catcactcta tgacaataaa tcacttcatt aaagatacaa tccaagtcac 134461 tcaatggctt ttagctcatt tttcaaaatc aaaactttac ctagccggtc attcttgggg 134521 atcaatactg gcgcttcatg tgctgcagca gcgtcctgat ttattttaca cgtattatgg 134581 aatcagccag gttgttaacc cgcaagatga agaatcaact gcttatcaac atattcgtga 134641 aatttccgaa tcaaaaaaag ccagcatatt atctttcctt acacgtttca ttggtgctcc 134701 gccttggaag caggatatcc agcaccttat ctatcggttt tgtgttgagc taaccagggg 134761 aggattcact caccgtcatc gtcaatctct cgctgtatta tttcaaatgc ttactggcaa 134821 tgagtatgga gtgcggaaca tgcacagctt ccttaatgga ttgcgcttca gtaaaaaaca 134881 tttaactgat gagttgtacc ggtttaatgc ttttacatca gttccttcta ttaaagtacc 134941 gtgtgttttc atttcaggga aacatgactt aattgttcct gcagaaatat cgaaacagta 135001 ttatcaagaa cttgaggcac ctgaaaagcg ctggtttcaa tttgagaatt cagctcacac 135061 cccgcatatt gaggagccat cattattcgc gaacacatta agtcggcatg cacgacacca 135121 tttatgatag atccttgata aataagaaaa acccctgtat aataaaaaaa gtgtgcaaat 135181 catgcatatt ttaaataagt cttgcaacat gcgcctattt tctgtataat ggtgtatgtt 135241 ggtctttgac tgcgatgaag tgagaggttg ctgacacacc cggccgcttt gccatggcaa 135301 ggtgttcagg tttttctcac ggagaactgt ctaacgtgat gtaggcgaaa aggagggaaa 135361 ataatggcaa aacaaaaaat tcgtattcgt ttgaaagcat atgatcatag aatccttgat 135421 caatctgcag agaagattgt tgaaacggca aaacgttctg gtgccagcgt atctggtccg 135481 attccgttgc caactgaaaa atcagtttac acaatccttc gtgcggtgca caaatacaaa 135541 gattctcgtg agcaatttga aatgcgtaca cataaacgtt taatcgacat tgtgaaccca 135601 acaccacaaa ctgttgatgc tcttatgcga ttagacttac catctggtgt cgatatcgaa 135661 attaaacttt aattctaaaa tatagaatga tcttaatagg aggtgtgacg aatgaccaaa 135721 ggaatcttag gaagaaaaat tggtatgacg caagtattcg ctgagaatgg tgatcttatt 135781 ccggtaactg ttatcgaggc tgctccaaac gttgttcttc aaaagaaaac agctgaaaac 135841 gacggttacg aagcaatcca gcttggtttt gacgacaagc gtgaaaagct ttctaacaaa 135901 cctgaaaaag ggcacgttgc aaaagcggaa actgctccta agcgcttcgt taaagaatta 135961 cgcggagtgg aaatggatgc gtatgaagtt ggtcaggaag tcaaggttga aattttctct 136021 gctggagaaa tcgtagatgt aacaggagta tctaaaggta aaggtttcca aggtgcgatc 136081 aagcgccacg gacaatctcg cggacctatg tctcacggtt cacgctacca ccgtcgtcct 136141 ggttcaatgg gacctgtaga tcctaaccgt gtattcaaag gtaaattatt acctggacgt 136201 atgggcggag agcaaatcac tgttcaaaac cttgaaatcg taaaagttga tgcagaacgc 136261 aatcttcttt tgatcaaagg taacgtacct ggtgcgaaga aatctttaat cactgttaaa 136321 agtgctgtta aatctaaata attctcttag gaaaggagga aattgattat gccaaaagta 136381 gcattataca accaaaacgg ttctactgct ggtgacatcg aattaaacgc ttctgtattt 136441 ggtatcgaac caaatgagag tgttgtattc gacgctattc ttatgcaaag agcttcctta 136501 cgtcaaggaa ctcacaaagt aaaaaatcgt tctgaagtac gcggcggagg tcgtaaacca 136561 tggcgtcaaa aaggtactgg acgtgcccgt caaggttcaa tccgttcacc gcaatggcgc 136621 ggaggtggtg tcgtattcgg cccaacacca cgcagctatt cttataaatt acctaaaaaa 136681 gttcgccgct tggcaatcaa atcagtattg tcttctaaag tgatcgacaa caacatcatc 136741 gttcttgaag atcttactct tgatacggct aaaacaaaag aaatggcagc tatccttaaa 136801 ggattatctg ttgagaaaaa agctttaatc gtaactgcgg atgcaaacga agcagtagca 136861 ttatctgctc gtaacattcc tggagttact gttgttgaag ctaacggaat caacgtttta 136921 gacgttgtca accacgagaa gcttctgatt acaaaagcag cggttgaaaa agtagaggag 136981 gtgcttgcat aatgaaagat cctcgtgatg ttctaaagcg ccccgtcatt actgaacgtt 137041 ctgccgattt aatgactgaa aaaaaatata cttttgaagt tgatgtaaga gctaacaaaa 137101 cagaagtgaa agacgcggtt gaaagcatct ttggagtgaa agttgacaaa gtcaacatca 137161 tgaactacaa aggcaaatca aaacgtgttg gacgctacac tggtatgact agccgtcgca 137221 gaaaagcgat cgtaaaactt actgcagaca gcaaagaaat cgaaattttt gaagcttaat 137281 tatctgtaaa aagaaggagg gaaattcaaa atggcgatta aaaagtataa accgacctct 137341 aatggacgtc gtggcatgac aacttcagat tttgctgaaa tcacgactga caagccggaa 137401 aaatccttgc ttgctcccct tcacaaaaaa ggcggacgta acaaccaagg taaattgact 137461 gtacgtcacc aaggtggcgg acataaacgc caataccgtg ttatcgactt caaacgcgat 137521 aaagatggta tacctggacg cgttgctaca gttgaatacg atccaaaccg ttcagctaac 137581 atcgctctaa tcaactatgc agacggagaa aaacgttaca ttcttgctcc taaaggaatt 137641 caagtaggta ctgaaatcat gtcaggtcct gaagctgaca ttaaagtagg taatgcactt 137701 ccacttatca acatccctgt tggtacagtt gtgcataaca ttgaattaaa acctggtaaa 137761 ggcggacagc ttgtacgttc agctggtaca tctgctcagg ttcttggtaa agaaggtaaa 137821 tacgttcttg tacgtcttaa ctctggtgaa gttcgcatga tcctttctgc ttgccgtgct 137881 tctatcggtc aagtaggtaa cgaacagcac gaacttatca acattggtaa agctggacgt 137941 tctcgctgga aaggcatccg tcctacagtt cgtggttctg taatgaaccc taacgatcac 138001 ccacacggtg gtggtgaagg acgtgcgcca atcggacgta aatcaccaat gtctccatgg 138061 ggcaaaccaa ctcttggatt caagactcgt aagaaaaaga acaaatccga taaatttatc 138121 gtacgtcgtc gtaaaaataa ataacggggt tgtctacggt tcttttcgga ccgtagtgca 138181 atcacgaagg gaggttccaa aatggctcgc agcttaaaaa aaggaccatt tgtcgatgga 138241 cacttgatga ctaaaatcga gaaattaaat gaaacagaca agaaacaagt cgtaaaaact 138301 tggtctcgtc gttctactat tttcccacag tttattggtc acacaatcgc agtctatgac 138361 ggacgtaaac acgtgcctgt attcatctct gaagatatgg tagggcacaa gttgggtgaa 138421 ttcgctccaa ctcgtacgta caaaggtcat gctagtgatg acaaaaaaac aagacgctaa 138481 gagaggaggc ttttaaatgc aagctaaagc tgttgcaaga acagtccgta ttgctcctcg 138541 taaagcacgt ctagtaatgg acctgattcg aggcaagcaa gtaggtgagg cagtatcaat 138601 cttgaacctt acaccaagag ctgcttctcc aattatcgag aaagtattaa aatccgctat 138661 tgcaaatgct gagcataact atgaaatgga cgctaacaac ctggttattt ctcaagcatt 138721 cgttgacgaa ggccctacgt taaaaagatt ccgcccacgt gctatgggac gtgcgagcca 138781 aatcaacaaa cgtacgagcc acattacaat cgttgtatca gaaaagaagg agggataagt 138841 agtgggtcaa aaggtaaatc cagtcggtct tcgtatcgga gtcattcgtg attgggaatc 138901 taagtggtac gctggtaaag attacgctga cttcctgcac gaagatttaa aaattcgtga 138961 atacattagc aaacgccttt ctgacgcttc tgtttctaaa gtagaaattg agcgtgcagc 139021 aaaccgcgtt aacattacga tccacacagc taagcctggt atggttatcg gtaaaggcgg 139081 ttctgaagtc gaagcacttc gcaaagccct taacagcctt actggcaagc gtgtacacat 139141 taacattctt gaaatcaaaa gagcagatct tgatgcacag ctagttgctg acaacatcgc 139201 tcgtcaatta gaaaaccgtg tttctttccg ccgtgcgcag aaacaacaaa tccaacgtac 139261 tatgcgtgct ggagcacaag gtgtgaaaac aatggtttct ggtcgtcttg gcggtgcaga 139321 tatcgctcgt tctgaatact acagtgaagg aactgttcca ttgcacacat tacgtgcgga 139381 cattgactat gcaacatctg aagctgatac tacttacggt aagcttggtg taaaagtctg 139441 gatctatcgt ggagaggttc ttcctactaa gaagaaaaat gaggaaggag gaaaataata 139501 tgttattacc aaaacgcgtt aaatatcgca gagagcatcg cggaaaaatg cgtggccgtg 139561 cgaaaggcgg tactgaagta catttcggag aattcggtat ccaagctcta gaagcttctt 139621 ggattactaa ccgtcaaatc gaagctgcac gtattgcgat gactcgttac atgaaacgtg 139681 gcggtaaagt ttggatcaaa attttccctt ctaaacctta cactgctaaa ccacttgagg 139741 tacgtatggg atccggtaaa ggggctccag aaggttgggt agctgttgta aaaccgggca 139801 aagttttatt tgaaatttct ggtgtgtctg aagaggttgc tcgtgaagcg cttcgccttg 139861 catctcacaa attgccaatt aaaacgaagt tcgtaaaacg tgaagaaatt ggtggtgaat 139921 caaatgaaag ctaatgaaat tcgtgacctt accactgctg aaattgaaca aaaagtaaag 139981 tctcttaaag aagaactttt caatcttcgc tttcaattag cgacaggaca acttgaaaat 140041 actgctcgca ttcgtgaagt gcgcaaagct atcgcgcgca tgaaaactgt gattcgtgaa 140101 agagaaattg ctgctaataa ataatcactg aggggaggtc gtgagcatga gcgaacgtaa 140161 ccaacgcaaa gtttaccaag gccgtgttgt ttctgacaaa atggataaaa ccattactgt 140221 tgttgttgag acatacaaaa aacatacact ttacggtaaa cgcgtaaaat actcaaaaaa 140281 attcaaagca catgatgaaa ataatcaagc taaaatcggt gacatcgtta agatcatgga 140341 aactcgtcca ttgtctgcaa ctaagcgttt ccgtctagtt gaagttgtcg aagaagctgt 140401 tattatctaa taaagttcgg aattcttttt ccgaagggag gtaacaaata atgattcaac 140461 aagagactcg tttaaaagta gctgacaact ctggcgcacg tgaagtactt actattaaag 140521 ttcttggtgg ttctggacgt aaaacagcta acattggtga tgtaattgtt tgcacggtta 140581 aacaagcaac accaggaggc gttgtcaaaa aaggtgaagt cgtaaaagct gttatcgttc 140641 gcactaaaag cggagcgcgc agaagtgacg gttcatacat cagcttcgat gagaatgcat 140701 gtgttatcat ccgtgacgac aagagcccac gcggaactcg tatcttcgga ccagttgctc 140761 gtgaattgcg tgaaaacaac tttatgaaaa ttgtttctct agctccagaa gttatctaat 140821 tgaaataaat gccttactca aggaggtgcg atcaggatgc atgtaaaaaa aggcgataaa 140881 gttatggtta tctctggtaa agataaaggc aaacaaggaa caatccttgc tgctttccct 140941 aaaaaggacc gcgttttagt tgaaggtgtt aacatggtaa agaaacactc taaaccaact 141001 caagctaacc ctcaaggcgg tatttctaat caagaggcgc caattcatgt atcaaacgtt 141061 atgccgctcg atcctaaaac aggtgaagtg actcgcgtag gatacaaagt ggaagatggc 141121 aaaaaagttc gtgtagcaaa aaaatctggg caagttctag ataaatagta ttaaaaggaa 141181 gggaggtcta tctcatgaac cgccttaaag aaaagtacaa taaagaaatt gcacctgctt 141241 taatgactaa gttcaactat gattcagtca tgcaagtgcc taaaatcgaa aaaatcgtaa 141301 tcaacatggg tgttggtgac gctgttcaaa acgccaaagc aatcgacagt gctgttgagg 141361 aattaacgtt tatcgcaggt caaaaacctg tcgttactcg tgcgaagaaa tcaattgctg 141421 gattccgtct tcgtgaggga atgcctatcg gtgcgaaagt aactcttcgc ggagagcgca 141481 tgtatgattt ccttgataaa cttatttctg tatctttacc gcgtgtacgt gacttccgcg 141541 gggtttctaa aaaatctttc gacggtcgcg gtaactacac acttggtatc aaagaacagt 141601 taatcttccc tgaaattgac tacgataaag taacaaaggt tcgcggaatg gacatcgtta 141661 tcgtaacaac tgctaatact gacgaagaag ctcgtgagct attaactcaa gtaggtatgc 141721 cgttccagaa ataatcaatg aaagggaggc gaaatcgtgg ctaaaaagtc tatgattgcg 141781 aaacaacaac gtacaccaaa gtttaaagta caagagtaca cacgctgtga acgctgcgga 141841 cgtccgcatt cagtcattcg taaatttaaa ctttgccgta tttgtttccg tgagcttgca 141901 tataaaggac aaattcctgg cgtgaaaaaa gccagctggt aatccccaag aaagggaagg 141961 aggtaattat ataatggtta tgacagatcc aattgcagat atgctaactc gtattcgcaa 142021 tgcaaacatg gtacgtcatg agaagcttga aattcctgct tctaaattga aaagagaaat 142081 tgctgaaatt ttaaagcgtg aaggtttcat tcgtgacgtt gagttcgtag aagacagcaa 142141 acaaggtatt atccgcgttt tcttgaaata cggacaaaac aacgagcgcg ttatcactgg 142201 tcttaaaaga atcagcaagc ctggtttgcg tgtttatgct aaatctaatg aagtaccccg 142261 cgtacttaac ggtcttggaa tcgcgattat ttctacatca caaggtgttt taacggacaa 142321 agaagcccgt gcaaaacaag ctggtggaga agttctagca tacgtttggt aagaagttta 142381 acatgaatgg aggtgtttgg tatgtctcgt gtaggtaaga agctacttga gattccttct 142441 gatgttacag taacgttaaa tgataacaac actgtagctg tgaaaggacc aaaaggagaa 142501 ttaactcgta cgtttcaccc tgatatggag attaaagtag aggacaatgt gcttacagtc 142561 gctcgtcctt ctgatcaaaa agagcaccgt gccctgcatg gtacgactcg cagtctgctt 142621 ggcaacatgg ttgaaggtgt atctaaagga tttgaaagag gtttggaatt agtcggtgtc 142681 ggttaccgtg cttctaaatc cggaaataaa cttgttttaa acgttggata ctctcatcct 142741 gttgagatcg ttcctgaaga aggcatcgaa atcgaagttc cttctcaaac aaaagtagtt 142801 gtaaaaggta cagacaaaga acgcgtagga gctattgctg ctaacatccg cgctgtacgt 142861 tctccagagc cttacaaagg taaaggaatc cgctacgaag gtgaagttgt tcgccgtaaa 142921 gaaggtaaat ctgctaagta agatcgctta aagtgaagaa aggagtgacc tagatgatta 142981 cgaaaactag caaaaatgct gctcgtctta aaagacacgc tcgtgttcgc gctaaacttt 143041 ccggtactgc tgaaagaccg cgcctgaacg ttttccgttc taacaagcac atttacgctc 143101 aaatcatcga tgatgtaaat ggtgtaacac ttgctagtgc atctactctc gataaagact 143161 tgaacgttga aagcactgga gatacttctg ctgctactaa agttggagaa ttagttgcaa 143221 aacgcgctgc tgaaaaaggc atttctgacg tagtatttga ccgtggcgga tacttatacc 143281 atggacgtgt aaaagctttg gctgatgccg ctcgtgaagc tggacttaaa ttttaataaa 143341 agaaggaggg acacatgatt atgcgtcgta ttgacccaag caaattagag ttagaagaac 143401 gcttagttac ggttaaccgc gtagcgaaag ttgttaaagg tggtcgtcgt ttccgcttcg 143461 cagctctagt cgttgtcggt gacaaaaacg gacacgtagg attcggtact ggtaaagcac 143521 aagaagtacc agaagcgatt cgcaaagctg ttgaagatgc gaaaaagaat ttgattgaag 143581 taccaatggt tggaactaca attccacacg aaatcatcgg acgtttcggt gcaggtaaca 143641 tcttgttaaa acctgcttct gaaggtactg gagttatcgc tggaggccct gtacgtgcgg 143701 tacttgagct agctggtgta gctgatatcc tttctaagtc tttaggttct aacacaccga 143761 tcaacatgat tcgtgcaaca cttcaaggtt taagtgaact taaacgtgct gaagacgttg 143821 cgaagcttcg tggaaaatct gtagaagaac tgttaggata aggagggaac attaatggct 143881 aaattagaaa ttaccctcaa acgaagtgta atcggtcgcc cggaagacca acgcgttact 143941 gtaagaacac ttggtttaaa gaaaacaaac caaactgttg ttcatgaaga caacgctgcg 144001 atccgtggta tgattaataa agtatctcat ttagtttctg ttaaagaaca ataaaaatat 144061 ttgatcggat aaggaggtgt cctaatgaaa cttcatgaat taaaaccttc agaaggttca 144121 cgcaaaacgc gtaatcgcgt aggtcgtggt attggttctg gcaacggtaa aacagctggt 144181 aaaggtcaca aaggtcaaaa cgctcgttct ggcggcggtg tacgccctgg attcgagggg 144241 ggacaaatgc ctttattcca acgtcttcct aaacgtggtt tcactaacat caaccgcaag 144301 gaatacgctg tagtcaacct agacaaattg aacggttttg cagaaggaac ggaagtcact 144361 cctgaacttc ttctagagac tggtgttatt agcaaactta atgcaggagt aaagattctt 144421 ggcaacggta aattagagaa aaaattaact gtaaaagcca ataaattctc tgcttctgcg 144481 aaagaagctg ttgaagctgc tggcggtaca gctgaggtga tctaacttgt ttaaaacaat 144541 ctccaacttt atgcgtgtga gtgatatcag gaataaaatc atattcactt tactcatgct 144601 tatcgtcttt cgcataggtg cgtttattcc tgtgccttac gttaacgctg aagcgttaca 144661 ggcacagtct caaatgggtg tttttgatct ccttaataca tttggcggcg gtgcgcttta 144721 ccaattttcc attttcgcaa tgggaattac tccttatatc acggcttcga tcatcattca 144781 gctgcttcag atggatgtgg taccgaagtt taccgagtgg tctaagcaag gtgaagttgg 144841 ccgccgtaaa ttagctcagt tcacaaggta ctttacgatt gtgcttggtt tcatccaagc 144901 gttaggtatg tcatatggat tcaacaatct ggcaaacggt atgctgatcg aaaaatccgg 144961 tgtatcgaca tatcttatca ttgctttagt gctcactggc ggaactgcct ttttaatgtg 145021 gcttggggaa caaattactt ctcatggagt aggcaacgga atatcgatca ttatcttcgc 145081 ggggattgtg tctagtattc caaaaacaat tgggcaaata tatgagactc aatttgtcgg 145141 cagcaacgat cagttgttta ttcatattgt gaaagtcgca cttcttgtga ttgcgatttt 145201 agcagttatt gttggagtta ttttcattca gcaagccgta cggaaaattg cgattcaata 145261 tgctaaaggc acaggtcgtt cacctgctgg cggaggtcag tctacacacc ttccattgaa 145321 agtgaatcct gcaggggtta ttccggtaat ctttgcggtt gcgtttttga taacgccgcg 145381 gacgatcgcg tcattctttg gaacaaacga tgtgacaaag tggattcaaa acaactttga 145441 taatacgcat ccggtgggta tggcgatata tgttgcgttg attattgcct ttacgtactt 145501 ttatgctttt gtacaggtaa accctgaaca aatggctgat aaccttaaaa aacagggtgg 145561 ctatatcccg ggggttcgtc cagggaaaat gactcaagat agaattacga gcattttgta 145621 tcgacttacg tttgtgggtt ctatattctt agccgtgatt tccattcttc ctatcttttt 145681 cattcaattc gctggattgc ctcaaagtgc acaaattggc ggaacatctt tgttaattgt 145741 tgtcggggta gccttggaga caatgaaaca actagaaagc cagttggtga aacgaaacta 145801 ccgtggattt atgaaaaact agaggaaatg gatttatcca ttccctctta ataaagagag 145861 gacgggggaa atccgaatga acttagtctt aatggggctt cctggtgccg gtaaaggcac 145921 acagggcgaa cgaattgttg aggattatgg gattcctcat atctcaacag gagatatgtt 145981 ccgtgctgct atgaaagaag aaacaccact cggactcgaa gcaaaatctt atattgataa 146041 gggagagctc gtacctgacg aagtcacaat cggaattgta aaagagagac ttggcaaaga 146101 tgattgtgaa agaggttttc ttctggacgg atttccgcga acagtcgctc aagccgaagc 146161 tcttgaagaa attcttgagg aatacggcaa gccgattgat tatgtcatta acattgaagt 146221 cgacaaagat gttctgatgg aacgtctgac tggacgcaga atttgcagtg tttgcggcac 146281 aacctatcat ttagtcttta atccgccgaa aacgccgggt atttgtgata aagacggagg 146341 cgaactctat caacgggcag atgataatga ggaaacagtc tctaaacggc ttgaggtaaa 146401 catgaagcaa actcagcctt tactcgattt ctattcagag aaaggttatc ttgcaaacgt 146461 gaatggccag caggacattc aagacgttta tgcagatgtg aaggatcttc ttggaggatt 146521 aaaaaaatga ttatctgtaa aaccccacgt gaacttggta tcatgcggga agcagggcga 146581 atcgtggctt taactcatga agagttaaaa aagcacatta aaccaggaat ctcgacaaaa 146641 gaattggatc aaattgccga acgttttatt aagaagcagg gtgcaatccc atcttttaag 146701 gggtataatg ggtttcgcgg gagcatttgc gtatcagtta atgaagaact cgttcacggc 146761 atacctggca gcagggtgct gaaggacggt gacatcatca gtattgatat cggtgctaaa 146821 ttaaatggtt atcatggtga ctctgcatgg acatatccgg taggaaacat cagcgatgat 146881 gacaaaaaac ttctggaagt gacagaggag tctttatata aaggcttgca ggaagcaaaa 146941 ccaggtgaac gtttgtcgaa tatttcccac gcaatacaaa cgtatgtcga aaatgagcag 147001 ttttcagttg ttagggagta tgtcggacat ggtgttggtc aagacttgca tgaggacccg 147061 caaattcctc attacggtcc gcccaacaaa ggaccacggc ttaaacctgg catggttctc 147121 gctattgaac ctatggtgaa cgctggcagc cgctacgtga aaacattggc tgataactgg 147181 acggttgtaa cggtagatgg gaaaaagtgt gctcattttg aacatacgat tgcgattacg 147241 gaaacgggtt ttgatatact gacgagagtc tagatgatga aaataattcc gaagacagat 147301 gtttttcaag cttgataggg cagaaagctt gggtgaacat tggcaagacc gaattcatct 147361 tgcttcttgt cgttggaatt ttaaccatca tcaatgtact aacagcagac ggagaaaagc 147421 gtacatttca ttctcctaag aaaaagaata tcaatcattt aaccctttat gattgcgtat 147481 ctccggaagt tcagaacagt ataaacgaaa cagggcgtgt gacaaacttc ttttgaaatt 147541 tgtcagaaag caagttactg atttgaagaa gggagaacac ttgaatggcg aaagacgatg 147601 taattgaagt ggaaggtact atagtcgaaa cactgccaaa cgcgatgttc aaagttgaac 147661 ttgaaaatgg ccacactgtt ttggctcatg tatctggtaa aatccgcatg cacttcattc 147721 gcattttacc tggagacaaa gttacggtag aattatctcc atatgactta actcgtggca 147781 ggattacgta ccgttacaaa taaagcactc cggaaactga aggaggttgg aaacacatga 147841 aagtgagacc atcagttaaa ccaatctgcg aaaaatgtaa agttattcgc agaaaaggaa 147901 aagtaatggt gatctgtgaa aatccaaagc ataaacaaaa acaaggataa tttataagga 147961 ggtgcccaga gaatggctcg tattgctggt gtagatatcc cacgtgacaa acgtgttgtt 148021 atttctttaa catacatctt cggaattggc cgcacaacgg ctcagcaagt tttaaaagaa 148081 gctggagttt cagaagatac tcgtgtgcgc gatcttactg aagaagaact tggtaaaatc 148141 cgtgatatta ttgacaaact gaaagtagaa ggtgaccttc gccgtgaagt ttctcttaat 148201 atcaaacgtc tgatcgaaat cggaagctac cgcggaatcc gtcatcgcag aggattacct 148261 gttcgcggac aaaactctaa aaacaacgcg cgtactcgta aaggtccgcg tcgtactgta 148321 gctaacaaga aaaaataagt aagggaggtt cttaaacaat ggctgctgct cgtaaatcta 148381 acacgcgtaa acgtcgcgtg aaaaagaata ttgagtctgg aattgctcat attcgttcaa 148441 ctttcaataa cacgatcgtt acgatcactg acactcatgg taatgctatt tcttggtcta 148501 gtgccggagc tttaggattc agaggttctc gtaaatctac tccttttgct gcgcaaatgg 148561 ctgcagaaac agctgctaaa ggttcaatcg aacatggtct taaaactcta gaggttactg 148621 ttaaaggacc tggttcaggc cgtgaagctg caatccgtgc acttcaagct gctggactag 148681 aagtcactgc tatcagagac gtaactcctg ttcctcataa cggatgccgt ccaccaaaac 148741 gtcgccgcgt gtaatttgtt tgtatagatt ttgtgtccct gtcaataatg ggttatgata 148801 cagttattta tgaaacgaat gcaccgactc gttgcctgag cacatacggg actaaacaat 148861 ggggaatttc ggatggaatc tcatatgatt ctattcgagg tttcgacgtt ttgaaggagg 148921 gttttaagta atgatcgaga ttgaaaaacc aaaaatcgaa acggttgaaa tcagcgacga 148981 tgccaaattt ggtaagtttg tcgtagagcc acttgagcgt ggatatggta caactctggg 149041 taactcctta cgtcgtatcc tcttatcctc actccctggt gccgctgtaa catcaatcca 149101 gatagatggt gtactgcacg aattctcgac aattgaaggc gttgtggaag atgttacaac 149161 gattatctta cacattaaaa agcttgcatt gaaaatctac tctgatgaag agaagacgct 149221 agaaattgat gtacagggtg aaggaactgt aacggcagct gatattacac acgatagtga 149281 tgtagagatc ttaaatcctg atcttcatat cgcgactctt ggtgagaatg cgagtttccg 149341 agttcgcctt actgctcaaa gaggacgtgg gtatacgcct gctgacgcaa acaagagaga 149401 cgatcagcca atcggcgtga ttccgatcga ttctatctat acgccagttt ctcgtgtatc 149461 ttatcaggta gagaacactc gtgtaggcca agttgcaaac tatgataaac ttacacttga 149521 tgtttggact gatggaagca ctggaccgaa agaagcaatt gcgcttggtt caaagatttt 149581 aactgaacac cttaatatat tcgttggttt aactgacgaa gctcaacatg ctgaaatcat 149641 ggttgaaaaa gaagaagatc aaaaagagaa agttcttgaa atgacaattg aagaattgga 149701 tctttctgtt cgttcttaca actgcttaaa gcgtgcgggt attaacacgg ttcaagagct 149761 tgcgaacaag acggaagaag atatgatgaa agttcgaaat ctaggacgca aatcacttga 149821 agaagtgaaa gcgaaactag aagaacttgg actcggactt cgcaaagacg attgactagt 149881 ttcccttgtg aactaggatt ttcgtgtgtt tattattcag aaacagcatt ccaataaagg 149941 aggggacatc acatgtcata cagaaaacta ggacgtacga gtgcacagcg taaagctatg 150001 cttcgtgatc ttacaactga tttgatcatc aacgaaagaa tcgaaacaac tgaaacacgt 150061 gcgaaagaac ttcgctctgt agttgaaaaa atgatcacgc ttggcaaacg cggtgatctt 150121 cacgctcgcc gtcaagctgc tgcatacatc cgcaacgagg ttgcaaacga agaaaataat 150181 caagatgcac ttcaaaaatt attctctgac attgcaactc gttacgagga gcgccaaggt 150241 ggatacacac gtattatgaa gcttggtcct cgccgtggtg acggagcacc aatggcaatt 150301 atcgaattgg tttaatcaca tatttttgtg tatctaaaga agggcgggac agtttctaac 150361 tggatctatg cccttttttt agatactgca acttttaata gagagaaaag cagagcatta 150421 gctgagagga ggccggtttt ccatgaatca aaatcagttg atatcggtag aggatatcgt 150481 atttcgatat cggaaggacg cagaaagacg agcactagac ggcgtctccc tgcaggtgta 150541 tgagggtgaa tggcttgcaa tcgtaggtca taacggttca gggaaatcaa cactggcccg 150601 ggcattgaat ggtttaattc ttcctgaatc aggcgacatt gaggttgccg ggattcaatt 150661 gacagaggaa tctgtttggg aagtgcgtaa gaagataggt atggtctttc aaaatccgga 150721 taaccaattt gtcggaacga ctgttcgcga tgatgtggct tttggtttag aaaacaatgg 150781 tgtaccgcgg gaagaaatga ttgagagagt agactgggca gtaaaacagg tgaatatgca 150841 agattttctc gatcaagagc cgcaccatct ctccggaggc caaaagcaga gagttgcgat 150901 tgcgggggtt attgccgcac gtcctgatat tattatctta gatgaagcaa catccatgct 150961 tgatccgatc gggcgagaag aagtgcttga aacggtaaga catttaaaag agcagggcat 151021 ggcgactgtc atatccatta cacatgacct gaatgaggca gcaaaagcag acaggatcat 151081 tgtcatgaat ggcggtaaaa aatatgctga agggccgcct gaagagattt ttaaattgaa 151141 taaagaactt gttcgaattg ggcttgattt acccttctca ttccagctta gccagctttt 151201 aagagaaaat ggactggctt tggaagaaaa ccatttgact caggaagggc tggtgaaaga 151261 gctgtggaca ttacaatcaa agatgtagag catcgctatc agatgaagac cccgtttgag 151321 cgcctagcac tgtatgatat caatgcatcg attaaagaag gaagctacgt agccgttatc 151381 gggcatacag gctctggcaa gtccactctt ctacagcacc taaatggtct cctgaagccg 151441 acgaagggac agatatcact aggcagcact gtcattcagg cagggaaaaa gaataaagat 151501 ctgaaaaaac ttcgtaaaaa agtcggaatc gttttccaat ttcctgagca tcaattattc 151561 gaagaaacag ttcttaaaga tatttcattc ggaccgatga actttggtgt taaaaaagaa 151621 gatgctgaac aaaaagcgag agagatgctg cagcttgtag gtttatcaga agagcttttg 151681 gacaggtcac cctttgaatt aagcggggga caaatgcgca gagttgcaat tgccggcgta 151741 cttgcaatgg accctgaagt gcttgttctg gatgaaccga ctgcaggatt ggacccaaga 151801 gggcgaaaag agattatgga catgttttat gagcttcatc aacgtgggaa cttgacgacg 151861 atccttgtga cacacagcat ggaggatgca gctgcatacg ctgatgaaat gattgttatg 151921 cataaaggaa cgatacaagc atcaggcagt ccgcgtgatc tgtttttaaa gggtgaagag 151981 atggccggct gggggctgga tcttcctgaa acaataaaat tccaaagaca ccttgaagct 152041 gcactgggtg tgagatttaa tgagcctatg ctcacaatcg aagatgccgc tgccgaaatc 152101 cgtgctcttt ttcagggaga gaagacttta tgatggacag catgattatc ggcaagtatg 152161 taccggggac ttcacttgtg caccggcttg accccagaac aaaactgatc acgatctttt 152221 tatttgtctg cattgtattc ttagccaata atgttcagac atatgcgttg cttggtttat 152281 ttacaattgg cgtcgtttct ttaacaagag ttcctttctc ttttttaatg aaagggctga 152341 agccaatcat ctggattgtc ctttttacgt tccttcttca cattcttatg acacatgaag 152401 gaccgattat ctttcaaata ggttttttca aagtctatga gggcggtctg gttcagggga 152461 tattcatttc tcttagattc gtctatttga ttttaatcac aaccttatta acgcttacga 152521 ctacaccgat tgagattacc gatggaatgg agcagctgct gaacccattg aaaaaattaa 152581 agcttcctgt tcatgagctg gctcttatga tgtcaatttc tttacggttt attccgacac 152641 tgatggagga gacagataag atcatgaagg ctcagatggc gcgaggcgtt gattttacaa 152701 gcgggcctgt caaagaaaga gtgaaggcta ttgtcccgct tcttgtcccg ctcttcgtca 152761 gcgcatttaa acgcgccgaa gagcttgcgg tggcaatgga agcaagaggc tatcaaggcg 152821 gagaaggacg tacgaaatat agaaagcttg tatggacagg aaaagacact tctgtcattg 152881 tcagcttaat tgtattagct gctttgttat ttttcttaag ggcttagagg tgctgtatga 152941 gactgaaatg cacgatttct tatgacggac atttgtttaa cggttatcag gttcagccgg 153001 gcaaaagaac ggttcaggat gaactggaga aggctttggc tgtcctgcat aagtcaaaag 153061 acagaattcc ggtcgtttcg tctggaagaa cagacagcgg ggttcacgca gccggacagg 153121 tgattcattt tgacactccg ctgtctatcc cggctgagag atggccatat gccttaaatg 153181 cactgcttcc ggacgatatc gcagtcaaac aggcagaaat tgcggatgat gggttccatg 153241 cacgatttag cgcagtcaaa aaagaatatc gctactttgt atacacggag aaacacccgg 153301 acgtatttaa acggcattac gcttaccatt tttcatatcg ccttaatgtg caggacatga 153361 gagaagcggc aaagcatctt atagggacac atgattttac gagcttttgc gcggctaaaa 153421 cagaagtgca ggacaaggta agaacgatat acgaacttga ttggactgag acggctgacg 153481 gcctgcaaat gcggatcaca ggcagcggtt tcttatataa tatggtcaga attattgcgg 153541 gtactttgct tgatgcaggt attggaaaaa tttctcccga tgaggtgaaa tccatgctgg 153601 aagcgaagga tcgcgaagcg gcagggcgca cagcgccggg gcacgggcta tatttatgga 153661 acgtttacta tgacaactaa accaggtgta taatattttc ttgacagagt ctgcataaag 153721 ttataagata tcatatggta tgtatttcaa ccccacgata agccccggaa cttattgtgt 153781 tgtgaaatag aacgtaatcg aagtttattg aaaatgacag atcatttagg agggaaattc 153841 aatgcgtaca acacctatgg ctaacgcaag tactattgaa cgcaagtggt tagttgttga 153901 tgctgctggc aagactttag gtcgtctttc ttcagaagtt gcagctatcc ttcgcggaaa 153961 acacaaacca acttacacac cacacgttga tactggagat catgtgatca tcatcaacgc 154021 tgaaaaaatc gagttaactg gtaaaaagtt aactgacaaa atctactacc gtcacactca 154081 acatccaggc ggattaaaat caagaactgc tcttgaaatg cgtacaaact accctgagaa 154141 aatgcttgag cttgctatca aaggcatgct tccaaaaggt tctctaggtc gtcaaatgtt 154201 caaaaaattg aacgtatacc gtggttctga gcatccacac gaagcacaaa aacctgaagt 154261 ttacgaactt cgcggttaat taaaaaggag gttaccaatt tggcacaggt tcaatattac 154321 ggtactggcc gtcgtaaaag ctctgtagcg cgtgtgcgtt tagttccagg agaaggccgt 154381 atcgtcgtta ataatcgtga aatcagcgaa catatcccat ctgcagcttt aatcgaagat 154441 atcaaacaac cattaacttt gactgaaaca gctggcactt atgatgtttt agtaaacgta 154501 catggaggcg gcctatctgg tcaagctgga gcaatccgtc acggtatcgc tcgtgctttg 154561 cttgaagcag atccagaata ccgtacaact cttaaacgtg caggtcttct gactcgtgac 154621 gctcgtatga aagaacgtaa aaaatacggt cttaaaggcg ctcgtcgtgc acctcagttc 154681 tcaaaacgtt aattttacgt tttcaaaaag ctctcgacct tgggttggga gcttttttct 154741 ttcaataaaa cgtggcagtc ccgcataaaa ataacaactg aatggacgct tgacggggtt 154801 aagcaaattg tttgtttata aacggtctct ttgtaataat catggtagat ttcattctta 154861 ttcaattgga agttcggtca atgtttatta tcgttatgtg atcagcccag ctccatctaa 154921 ccactgtatc tcatccgtta aagttcactg ctgattctta acccggagaa acaatagctc 154981 tcattgctaa tggctttatg taacgaagta aaagtaaatc tgatgatata aatcacatat 155041 ctcctttgtg atttttttgc gtttttatga acttttttct aaatatgcaa agggaaagcg 155101 atatcaatct agaaatattt gttatactct atacattaaa gtaaggagaa gattcatgaa 155161 tgcgttagta gctcataata gcaaagcctg ggataaaaaa gtagaaacag gcaatgaatg 155221 gactgttgct gttgaacagc aggttatcga acaagcaaaa aaaggcaatt gggatataag 155281 ggtaacacca atgaaagatg taccgaagga ttggtttccg cctatcaaag gtctgaaagt 155341 actctgttta gcatcaggcg gcggccagca gggtccagtt ttggcagccg caggcgcgga 155401 tgtcactgta ttagataact cagaaaaaca gctgaatcag gatagaatga ttgctgagcg 155461 agatggtctg acgatacaca ctgtcaaagg aagcatggac gatttaagtg tatttaatga 155521 tgaatcattt gatgtcattg tacatcctgt tgccaatgtt tttgttgaga atgtcctccc 155581 ggtatggaag gaagcgtacc gtgtgttgaa aaggaacggc attctaatct cgggttttgt 155641 caatcctgtt gtatttctgt ttgatacaga attagaacag caaggtgttt taaaagtaaa 155701 acactctatt ccatacgctg acccagaaga tcttccgaaa cataaagtga aaaaactgat 155761 cgaaaataat gaggctctgg aattcggcca ttccttagaa gaccaaatca aaggccaaat 155821 tgatgccggt tttatcgtta ctggttttta tgaagataaa ggcggttttg tattagacca 155881 atatatccat acatattctg caacaagaag cgtgaaagta tgaaaagcag cgacctgtta 155941 gaggggctgc ttttttcata accaattaca gaacatttgt tcctcaccct gcagaaagct 156001 gattttttat caatgttaca ccttcatttg ggcgaatttc caaccgaatt cgggcattgt 156061 ttcatcatcc aaacctcaaa ataatcggta aaaggagagt gaatttatat ggcagaagta 156121 ctgtctttta tggatgtgaa acgccaaaag gattttgaat tagaaaagaa cttgctcaaa 156181 gaactctctc tgagacaaat tatccagtct gttaaggatt gtttggaacc attatttcca 156241 tttttacatg atgaacgaga tattattacc gaaggctgta ttgattttgc gattgaagct 156301 tatttgttag gcgggcgttt tgggatattc ggctattacg gagaatcaat gcagagtatc 156361 agtgcccgct ctgcaagaga agaagaagag ctgcgtatgg agttttttga ttatctctat 156421 aattggatac acgagcaata cgcaacattt gataaaaaca ctgtttatga agcggcacgc 156481 aagttcatta aagattggtg gacagcaggg tttgttcaaa gagaaaaaca gtgtaagctt 156541 cgcatgcggt aatcatattt cccgaccctg tcccatagtt atgtaataac ggacaagcgg 156601 gaggggaagg gatgaggaaa aagcttaaat ggctcagttt tttgctaggc ttcatcatat 156661 tactatttct gttcaagtat cagttcagca ataacgactc ttggaagccg tggagcctgc 156721 ccttgagcgg taaaatcatt tatctagatc caggtcatgg cgggcctgac ggcggagcag 156781 tcggcggaaa gctgttagag aaggatgtta ccctggaagt ggcctttaga gtcagggatt 156841 atcttcaaga acaaggagcg cttgttatca tgaccagaga aagtgatact gatctcgctc 156901 cagaaggaac aaaaggctat agccgacgaa aagctgagga tctaagacaa cgagtcaaat 156961 taataaacca ttcagaggcg gagctctata tcagcattca tcttaatgcg attccgtcac 157021 aaaaatggag cggagcccaa agcttttatt acgggaaata tgcggaaaat gagaaagtcg 157081 caaaatacat tcaggatgag ctgagaagaa atctggaaaa cacaacccgg aaagcaaagc 157141 ggattcatgg tatctactta atgcaaaacg tcaccaaacc gggggcgctt atagaagtcg 157201 gatttttatc caatccaagt gaagcaacgt tgctcggtaa accgaaatat caagacaagg 157261 tggcatcttc catatataaa ggcattttgc gatatttcac agaaaaagga gaccctccgg 157321 agtaatggag ggttttcttg tggttctaag cataagacac ccgccattta tgtatgatat 157381 aataataatt gtaaacgaat acacaaaagg gtgaggttcg atgataagag aagatgaagt 157441 aagaaaacta gtcggagaaa tgcgcgaacc ttttcttcaa agacctctgg gagaattgga 157501 tgccgttaag gaaattaaaa taaagcctga aaaacggcat atcagtgtaa aagtcgctct 157561 tgcaaaaaca ggaactgcag aacaaatgca gattcagcaa gagatcgtaa acgtattaaa 157621 aggggcagga gctgagacag tcggccttcg atttgaagag ctgcctgaag aaacggttgc 157681 taaattccgg gcgccgtcag ctgagaaaaa aacattatta aatatggata acccgccagt 157741 ctttcttgct gtagcaagtg gaaaaggcgg cgtaggcaag tcaactgtgt cagtaaacct 157801 agctatttct ctggctcgtc tagggaaaaa ggttggttta attgatgcgg atatttatgg 157861 gttcagtgtg ccggacatga tgggtatcac tgtgcgtcca acaattgaag gagagaaact 157921 tcttcctgtt gaacgctttg gagtaaaggt catgtcaatg ggctttttcg tagaagaaaa 157981 tgccccggtc gtatggagag ggccgatgct cggcaaaatg ctgaataatt ttttccatga 158041 agtagagtgg ggagaagtag actatatcgt tcttgatctt ccgcctggta caggggacgt 158101 tgctctcgat gtacatacaa tgcttccgag ctgcaaagaa attatcgtat ctacgccaca 158161 tccgacagct gcttttgtcg cggccagagc gggctctatg gcgattaaaa ccgatcatga 158221 ggtcgtgggt gtcatagaga acatggctta ttatgaaagt gcaaagacag gggaaagaga 158281 atatgtgttt ggaaaaggcg gaggagataa actggctgag gaactaaacg tgcctttgct 158341 cggcagaatc ccattgaaac agcccgattg ggataaggac caatttgctc cgtctgttta 158401 tgacgaaaat catccaatcg gagaaatata tcaggacatc gcaaaaaaaa tagatgcaaa 158461 aatgtcagtg caggtataaa aggtgaaccg ggattccaga tcccggcttt ccctttattc 158521 actttctttt gctgtgtctt ttgctgcttt tttcagctca tcttcgaact gctttttgta 158581 aagcggacta gaaagtgttt cgttaataac ctcttctaaa taactgcgga attcttggct 158641 ttttgccagc tggctgtact ttttatccat gccgggatcc tgcataacgc tcatcagcat 158701 cttctggtaa tctggatcct tcatcagctt tttaatcact ttttcatgct ctgtctgaag 158761 agttttggca aagccctcag caaaatcagt gtcttcaaag atgtttttcc aaaattcttc 158821 acctttttta gatgtgagtg ttttttctat tgttccttta attgcatctt ggtcaatcac 158881 cagcgcttca ttcatggcat catcatttaa taattcctta atagctttct ttccatcatc 158941 agtttttaat atatcaacaa ccattttttt ggtctgatca tagtccatat ccgctgcttg 159001 gtcttttgga gcgcaagctg ttacagataa taacaaaaaa cagctcatca atagcgtttt 159061 ggcttttgac atgcttaagc tcctttcaca tacttgtctt acctttaata tgattcatct 159121 gtttggaatt atacataaca aaatatcgct gttcgcgatt tttgagggga tgaataaaga 159181 aatgaaaagc cgtggtttag ttcgtttttt cttttctatt ttagctgtcg gggcgcttat 159241 cacgagtatt gtgggttttg ctttaaagtg gggagaatat agagggctgt ttctaacatt 159301 tgaagcggga cagattttct ctgttttatt ttggtttatc ggtgtaggca tgattttcag 159361 tgtgatcagc caaatgggtt ttttcgtgtt tttaacagtt catcggtttg cgcttgagat 159421 attaaggtcc tcctctttgt ggaatttgct gcagttgttt ttcatcctgt ttgttgcttt 159481 tgatttaatg tacgtgcgtt ttttattttt tggagagagc ggagaatcgc tggctggcta 159541 tgcgtggtta ccggtgtttt tattgatctt tggagtgatt acagcttata taaagcaaaa 159601 gcagtcctct aagaaaacat ttgtgtcatc gttatttttg atggttgtga ttaccgcatt 159661 agaatggttc cctgcattaa gagtaaatga tgaggactgg ctttatttaa tgctttttcc 159721 gttaatggca tgtaatgcct tccaattgct gatgctgccg aagtttgcag caaagtaatt 159781 actttacctc tgcggatttg gcatcagaat ttgcgatgag atcacccacg gttacatttt 159841 ttaatccttt ttctttcagc tgatggatga tatcaggcaa tgcttcttct gtttgttttg 159901 cagaatcgga ggcatgtaaa agaataatgt ctccaccgga aacttgcttg gtcacattgt 159961 cgatgatttt ttcaactccg ggatttgtcc agtcttgaga gttcacactg taatgaacga 160021 ctgtataatt gtattgcttt gcgaccttta gaacattctt attgaattgg ccggtagggg 160081 gtcttaatag ctgtatgtct ttgaccccta acttttcaaa ggctgtttgc gcacggttca 160141 tgtccttttt tatttcgctg ctctctaaat tggcatagtt tttataagcg tagcccatgc 160201 tcccgatttg atggccgtcc tttacgatac gggccactgt gtcgggatgg cgttctgccc 160261 aagaagcgga caggaaaaac gttgcgtttt taatcccgtt tgctttcaga gtattaagta 160321 tcggttctgc tctctcatca ccccagctga tatcgaaagt aagtgaaata tctttagagt 160381 ctgtttctcc tttataaatg gctttaggtc cggtgtcagt tgaaaacacg ggaagcggga 160441 cagctctttg gatataaaaa aagctggcag ctgcaaatgc ggcgataagt ataataatta 160501 attgttttac ccgtttaatg tgccacacat agaagtgatt cactgatgat gcctccttat 160561 cttgtccatc attcttgttt tacatcttat gagcatggac aattgaatat aaccgataaa 160621 atgtctcttc acatacagcc taaattgggt gttgaccttt tgataatatc cgtgatatat 160681 tattattcgt cgctgataaa cagctgacat caactaaaag cttcattaaa tactttgaaa 160741 aaagttgttg acttaaaaga agctaaatgt tatagtaata aagctgcttc gttaagcggc 160801 agtaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcat ttttataaat 160861 cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat cctggctcag 160921 gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg gagcttgctc 160981 cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta agactgggat 161041 aactccggga aaccggggct aataccggat ggttgtttga accgcatggt tcaaacataa 161101 aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag ttggtgaggt 161161 aatggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc cacactggga 161221 ctgagacacg gcccagactc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 161281 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 161341 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 161401 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagctt tgtccggaat 161461 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 161521 accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca 161581 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 161641 gtctgtaact gacgctgagg agcgaaaacg tggggagcga acaggattag ataccctggt 161701 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 161761 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 161821 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 161881 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 161941 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 162001 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 162061 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 162121 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 162181 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 162241 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 162301 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 162361 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 162421 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 162481 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 162541 ttgaaaacta gataacagta gacatcacat tcaagtaata caagatatca catagtgatt 162601 ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta ggagccgatg 162661 aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg atccggagat 162721 ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga attcatagga 162781 tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag agaaagcaaa 162841 tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga ggcttgcctc 162901 tggggttgta ggacactctg tacggagtta caaaggaacg aggtagatga agaggtctgg 162961 aaaggcccgc cataggaggt aacagccctg tagtcaaaac ttcgttctct cctgagtgga 163021 tcctgagtac ggcggaacac gtgaaattcc gtcggaatcc gggaggacca tctcccaagg 163081 ctaaatactc cctagtgacc gatagtgaac cagtaccgtg agggaaaggt gaaaagcacc 163141 ccggaagggg agtgaaagag atcctgaaac cgtgtgccta caagtagtca gagcccgtta 163201 acgggtgatg gcgtgccttt tgtagaatga accggcgagt tacgatctcg tgcaaggtta 163261 agcagaagat gcggagccgc agcgaaagcg agtctgaata gggcgcatga gtacgtggtc 163321 gtagacccga aaccaggtga tctacccatg tccagggtga agttcaggta acactgaatg 163381 gaggcccgaa cccacgcacg ttgaaaagtg cggggatgag gtgtgggtag gggtgaaatg 163441 ccaatcgagc ctggagatag ctggttctct ccgaaatagc tttagggcta gcctcaaggt 163501 aagagtcttg gaggtagagc actgattgga ctaggggccc ctaccgggtt accgaattca 163561 gtcaaactcc gaatgccaat gacttatcct tgggagtcag actgcgagtg ataagatccg 163621 tagtcgaaag ggaaacagcc cagaccgcca gctaaggtcc caaagtatac gttaagtgga 163681 aaaggatgtg gagttgctta gacaaccagg atgttggctt agaagcagcc accatttaaa 163741 gagtgcgtaa tagctcactg gtcgagtgac tctgcgccga aaatgtaccg gggctaaacg 163801 tatcaccgaa gctgcggact gttcttcgaa cagtggtagg agagcgttct aagggctgtg 163861 aagccagacc ggaaggactg gtggagcgct tagaagtgag aatgccggta tgagtagcga 163921 aagaggggtg agaatcccct ccaccgaatg cctaaggttt cctgaggaag gctcgtccgc 163981 tcagggttag tcgggaccta agccgaggcc gaaaggcgta ggcgatggac aacaggttga 164041 tattcctgta ccacctcctc accatttgag caatgggggg acgcaggagg atagggtaag 164101 cgcggtattg gatatccgcg tccaagcagt taggctggga aataggcaaa tccgtttccc 164161 ataaggctga gctgtgatgg cgagcgaaat atagtagcga agttcctgat tccacactgc 164221 caagaaaagc ctctagcgag gtgagaggtg cccgtaccgc aaaccgacac aggtaggcga 164281 ggagagaatc ctaaggtgat cgagagaact ctcgttaagg aactcggcaa aatgaccccg 164341 taacttcggg agaaggggtg ctctgttagg gtgcaagccc gagagagccg cagtgaatag 164401 gcccaggcga ctgtttagca aaaacacagg tctctgcgaa gccgtaaggc gaagtatagg 164461 ggctgacgcc tgcccggtgc tggaaggtta agaggagcgc ttagcgtaag cgaaggtgcg 164521 aattgaagcc ccagtaaacg gcggccgtaa ctataacggt cctaaggtag cgaaattcct 164581 tgtcgggtaa gttccgaccc gcacgaaagg cgcaacgatc tgggcactgt ctcaacgaga 164641 gactcggtga aattatagta cctgtgaaga tgcaggttac ccgcgacagg acggaaagac 164701 cccgtggagc tttactgcag cctgatattg aatgttggta cagcttgtac aggataggta 164761 ggagccttgg aaaccggagc gccagcttcg gtggaggcat cggtgggata ctaccctggc 164821 tgtattgacc ttctaacccg ccgcccttat cgggcgggga gacagtttca ggtgggcagt 164881 ttgactgggg cggtcgcctc ctaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg 164941 ttggaaatca ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc 165001 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc 165061 aacggataaa agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg 165121 gggaggtttg gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg 165181 gttgggctgt tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt 165241 tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg 165301 accgggatgg acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct 165361 atgtgcggac gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat 165421 ttcccattcc gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg 165481 gaagtgtggc gacacatgga gctgacagat actaatcgat cgaggactta accatatttt 165541 tgaatgatgt cacatctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg 165601 atagcgaaga ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg 165661 atggtagtcg ggggtttccc cctgtgagag taggacgccg ccaagcagat ttattaattc 165721 taccatgttt gtttatgaag ctttatatct cattccgcag tagctcagtg gtagagctat 165781 cggctgttaa ccgatcggtc gtaggttcga atcctacctg cggagcattg cttccatagc 165841 tcagcaggta gagcacttcc atggtaagga agaggtcagc ggttcgagcc cgcttggaag 165901 cttaaatgta ttattaccaa ggtttctcat aaggagaaag ctttttttat tgcgatatgc 165961 ggaagtagtt cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc 166021 gtcttccgct ccatttacct aacgggatat tgtaaattga attgcgcccg tagctcaatt 166081 ggatagagcg tttgactacg gatcaaaagg ttaggggttc gactcctctc gggcgcgcca 166141 tatcttttaa tagaatagat aggaaatcgg gaagtagctc agcttggtag agcacatggt 166201 ttgggaccat ggggtcgcag gttcgaatcc tgtcttcccg accatttttt atggggcctt 166261 agctcagctg ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg 166321 ctccaccaaa agtttttaaa aaaggttatt gactttgaag aagtgacatt gtatactaat 166381 aaagttgctt taacaaagcg gacaaacaaa atgatctttg aaaactaaac aagacaaaac 166441 gtacctgtta attcagtttt taaaaatcgc acagcgatgt gcgtagtcag tcaaactact 166501 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 166561 gtcgagcgga cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 166621 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 166681 tgtttgaacc gcatggttca aacctaaaag gtggcttcgg ctaccactta cagatggacc 166741 cgcggcgcat tagctagttg gtgaggtaac ggctcaccaa ggcaacgatg cgtagccgac 166801 ctgagagggt gatccggcca cactgggact gagacacggc ccagactcta cgggaggcag 166861 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 166921 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 166981 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 167041 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 167101 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt 167161 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 167221 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 167281 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 167341 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 167401 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 167461 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 167521 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 167581 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 167641 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 167701 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 167761 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 167821 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 167881 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 167941 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 168001 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 168061 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 168121 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 168181 aagtaataca agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg 168241 gtggatgcct tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg 168301 agctgtaagc aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg 168361 agtggtatcc atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat 168421 ctaagtaccc ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg 168481 gattagccca aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac 168541 aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt 168601 agtcaaaact tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg 168661 tcggaatccg ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc 168721 agtaccgtga gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc 168781 gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa 168841 ccggcgagtt acgatctcgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga 168901 gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt 168961 ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc 169021 ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc 169081 cgaaatagct ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac 169141 taggggcccc taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt 169201 gggagtcaga ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag 169261 ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga 169321 tgttggctta gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact 169381 ctggcccgaa aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac 169441 agtggtagga gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt 169501 agaagtgaga atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc 169561 ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg 169621 aaaggcgtag gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc 169681 aatgggggga cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt 169741 aggctgggaa ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata 169801 tagtagcgaa gttcctgatt ccacactgcc aagaaaagct ctagcgaggt gagaggtgcc 169861 cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg agagaactct 169921 cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgcc ctgttagggt 169981 gcaacccgag agaaccgcag tgaataggcc ccaggcgact gtttagcaaa acacaggtct 170041 ctgcgaagcc gtaaggcgaa gtatagggct gacgcctgcc cggtgctgga aggttaagag 170101 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 170161 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 170221 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 170281 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 170341 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca cttcggtgga 170401 ggcatcggtg ggatactacc ctggctgtat tgaccttcta acccgccgcc cttatcgggc 170461 ggggagacag tgtcaggtgg gcagtttgac tggggcggtc gcctcctaaa aggtaacgga 170521 ggcgcccaaa ggttccctca gaatggttgg aaatcattcg cagagtgtaa aggcacaagg 170581 gagcttgact gcgagaccta caagtcgagc agggacgaaa gtcgggctta gtgatccggt 170641 ggttccgcat ggaagggcca tcgctcaacg gataaaagct accccgggga taacaggctt 170701 atctccccca agagtccaca tcgacgggga ggtttggcac ctcgatgtcg gctcatcgca 170761 tcctggggct gtagtcggtc ccaagggttg ggctgttcgc ccattaaagc ggtacgcgag 170821 ctgggttcag aacgtcgtga gacagttcgg tccctatccg tcgcgggcgc aggaaatttg 170881 agaggagctg tccttagtac gagaggaccg ggatggacgc accgctggtg taccagttgt 170941 tctgccaagg gcatcgctgg gtagctatgt gcggacggga taagtgctga aagcatctaa 171001 gcatgaagcc cccctcaaga tgagatttcc cattccgcaa ggaagtaaga tccctgaaag 171061 atgatcaggt tgataggtct gaggtggaag tgtggcgaca catggagctg acagatacta 171121 atcgatcgag gacttaacca tatttttgaa tgatgtcaca cctgttatct agttttgaga 171181 gaacactctc aatttgtttg gtggcgatag cgaagaggtc acacccgttc ccataccgaa 171241 cacggaagtt aagctcttca gcgccgatgg tagtcggggg tttccccctg tgagagtagg 171301 acgccgccaa gcaattgcac attagtgtaa ttttttaaaa aagttattga ctttgaagaa 171361 gtgacattgt atactaataa agttgcttta acaaagcgga caaacaaaat gatctttgaa 171421 aactaaacaa gacaaaacgt acctgttaat tcagttttta aaaatcgcac agcgatgtgc 171481 gtagtcagtc aaactacttt atcggagagt ttgatcctgg ctcaggacga acgctggcgg 171541 cgtgcctaat acatgcaagt cgagcggaca gatgggagct tgctccctga tgttagcggc 171601 ggacgggtga gtaacacgtg ggtaacctgc ctgtaagact gggataactc cgggaaaccg 171661 gggctaatac cggatggtta gtttgaaccg catggttcaa acataaaagg tggcttcggc 171721 taccacttac agatggaccc gcggcgcatt agctagttgg tgaggtaacg gctcaccaag 171781 gcaacgatgc gtagccgacc tgagagggtg atcggccaca ctgggactga gacacggccc 171841 agactcctac gggaggcagc agtagggaat cttccgcaat ggacgaaagt ctgacggagc 171901 aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct ctgttgttag ggaagaacaa 171961 gtaccgttcg aatagggcgg taccttgacg gtacctaacc agaaagccac ggctaactac 172021 gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt ccggaattat tgggcgtaaa 172081 gggctcgcag gcggtttctt aagtctgatg tgaaagcccc cggctcaacc ggggagggtc 172141 attggaaact ggggaacttg agtgcagaag aggagagtgg aattccacgt gtagcggtga 172201 aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga ctctctggtc tgtaactgac 172261 gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt ccacgccgta 172321 aacgatgagt gctaagtgtt agggggtttc cgccccttag tgctgcagct aacgcattaa 172381 gcactccgcc tggggagtac ggtcgcaaga ctgaaactca aaggaattga cgggggcccg 172441 cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg aagaacctta ccaggtcttg 172501 acatcctctg acaatcctag agataggact gtcttcgggg gcagagtgac aggtggtgca 172561 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 172621 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 172681 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 172741 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 172801 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 172861 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 172921 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaagtggga 172981 cagatgattg gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc 173041 tcctttctaa ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc 173101 tgtcttgttt agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac 173161 agtagacatc acattcaagt aatacaagat atcacatagt gattcttttt aacggttaag 173221 ttagaaaggg cgcacggtgg atgccttggc actaggagcc gatgaaggac gggacgaaca 173281 ccgatatgct tcggggagct gtaagcaagc tttgatccgg agatttccga atggggaaac 173341 ccaccactcg taatggagtg gtatccatat ctgaattcat aggatatgag aaggcagacc 173401 cggggaactg aaacatctaa gtacccggag gaagagaaag caaatgcgat tccctgagta 173461 gcggcgagcg aaacgggatt agcccaaacc aagaggcttg cctcttgggg ttgtaggaca 173521 ctctgtacgg agttacaaag gaacgaggta gatgaagagg tctggaaagg cccgccatag 173581 gaggtaacag ccctgtagtc aaaacttcgt tctctcctga gtggatcctg agtacggcgg 173641 aacacgtgaa attccgtcgg aatccgggag gaccatctcc caaggctaaa tactccctag 173701 tgaccgatag tgaaccagta ccgtgaggga aaggtgaaaa gcaccccgga aggggagtga 173761 aagagatcct gaaaccgtgt gcctacaagt agtcagagcc cgttaacggg tgatggcgtg 173821 ccttttgtag aatgaaccgg cgagttacga tctcgtgcaa ggttaagcag aagatgcgga 173881 gccgcagcga aagcgagtct gaatagggcg catgagtacg tggtcgtaga cccgaaacca 173941 ggtgatctac ccatgtccag ggtgaagttc aggtaacact gaatggaggc ccgaacccac 174001 gcacgttgaa aagtgcgggg atgaggtgtg ggtaggggtg aaatgccaat cgaacctgga 174061 gatagctggt tctctccgaa atagctttag ggctagcctc aaggtaagag tcttggaggt 174121 agagcactga ttggactagg ggcccctacc gggttaccga attcagtcaa actccgaatg 174181 ccaatgactt atccttggga gtcagactgc gagtgataag atccgtagtc gaaagggaaa 174241 cagcccagac cgccagctaa ggtcccaaag tatacgttaa gtggaaaagg atgtggagtt 174301 gcttagacaa ccaggatgtt ggcttagaag cagccaccat ttaaagagtg cgtaatagct 174361 cactggtcga gtgactctgc gccgaaaatg taccggggct aaacgtatca ccgaagctgc 174421 ggactgttct tcgaacagtg gtaggagagc gttctaaggg ctgtgaagcc agaccggaag 174481 gactggtgga gcgcttagaa gtgagaatgc cggtatgagt agcgaaagag gggtgagaat 174541 cccctccacc gaatgcctaa ggtttcctga ggaaggctcg tccgctcagg gttagtcggg 174601 acctaagccg aggccgaaag gcgtaggcga tggacaacag gttgatattc ctgtaccacc 174661 tcctcaccat ttgagcaatg gggggacgca ggaggatagg gtaagcgcgg tattggatat 174721 ccgcgtccaa gcagttaggc tgggaaatag ggaaatccgt ttcccataag gctgagctgt 174781 gatggcgagc gaaatatagt agcgaagttc ctgattccac actgccaaga aaagcctcta 174841 gcgaggtgag aggtgcccgt accgcaaacc gacacaggta ggcgaggaga gaatcctaag 174901 gtgatcgaga gaactctcgt taaggaactc ggcaaaatga ccccgtaact tcgggagaag 174961 gggtgctctg ttagggtgca agcccgagag agccgcagtg aataggccca ggcgactgtt 175021 tagcaaaaac acaggtctct gcgaagccgt aaggcgaagt ataggggctg acgcctgccc 175081 ggtgctggaa ggttaagagg agcgcttagc gtaagcgaag gtgcgaattg aagccccagt 175141 aaacggcggc cgtaactata acggtcctaa ggtagcgaaa ttccttgtcg ggtaagttcc 175201 gacccgcacg aaaggcgcaa cgatctgggc actgtctcaa cgagagactc ggtgaaatta 175261 tagtacctgt gaagatgcag gttacccgcg acaggacgga aagaccccgt ggagctttac 175321 tgcagcctga tattgaatgt tggtacagct tgtacaggat aggtaggagc cttggaaacc 175381 ggagcgccag cttcggtgga ggcatcggtg ggatactacc ctggctgtat tgaccttcta 175441 acccgccgcc cttatcgggc ggggagacag tgtcaggtgg gcagtttgac tggggcggtc 175501 gcctcctaaa aggtaacgga ggcgcccaaa ggttccctca gaatggttgg aaatcattcg 175561 cagagtgtaa aggcacaagg gagcttgact gcgagaccta caagtcgagc agggacgaaa 175621 gtcgggctta gtgatccggt ggttccgcat ggaagggcca tcgctcaacg gataaaagct 175681 accccgggga taacaggctt atctccccca agagtccaca tcgacgggga ggtttggcac 175741 ctcgatgtcg gctcatcgca tcctggggct gtagtcggtc ccaagggttg ggctgttcgc 175801 ccattaaagc ggtacgcgag ctgggttcag aacgtcgtga gacagttcgg tccctatccg 175861 tcgcgggcgc aggaaatttg agaggagctg tccttagtac gagaggaccg ggatggacgc 175921 accgctggtg taccagttgt tctgccaagg gcatcgctgg gtagctatgt gcggacggga 175981 taagtgctga aagcatctaa gcatgaagcc cccctcaaga tgagatttcc cattccgcaa 176041 ggaagtaaga tccctgaaag atgatcaggt tgataggtct gaggtggaag tgtggcgaca 176101 catggagctg acagatacta atcgatcgag gacttaacca tatttttgaa tgatgtcaca 176161 cctgttatct agttttgaga gaacactctc aatttgtttg gtggcgatag cgaagaggtc 176221 acacccgttc ccataccgaa cacggaagtt aagctcttca gcgccgatgg tagtcggggg 176281 tttccccctg tgagagtagg acgccgccaa gcaagcttaa acccagctca ttgagctggg 176341 ttttttgttt tatatctgtg ccgatttgct ttcgtcagta tccattttat caagcttctg 176401 ctttttaaag ttttctaata cttttgaatt ccaatacaat ccctagcatg atcaacatga 176461 gagtcataaa taatcaaaat gcagtttgta cgggagactc atccagactc catccgactg 176521 cgattggcag gatagagccg ccaatccatt ggcagcgaac agcatgcttg tcgtttgttc 176581 tgtttttcca tgataaaatt gattggtgac aataaaataa tggcgaacat gccggccata 176641 aataagtcct aagaaaaaac taagaataat ccctgcaaaa gctgttttat tgattgccaa 176701 aatacagagt taaatgaggc cgctcatatt tatcagcctg agataatgat gataggttat 176761 tttttcggaa accagctcgg gttgccaaat gagagaaaag atattactgt cattaaaacg 176821 attcttggtt tcatccggat atgataaaat gtctcagact atatttgagc catttttttc 176881 ttcagcaatc atcttgcgta attgataaaa atttattatg atactctttg tatgacaact 176941 ccttgcctca atacaatata ctcaacgttt ccccgttttc tccggtcgtt tttcttttca 177001 ttttctcccg taaaataaaa aaagctccca atacaataga tatggtgcgg atttattttt 177061 tactaaaaag gagtcgttat atttgaataa tagttttaca ttaaaacagc aatggttcgg 177121 gaatatccga aaagacattc ttgctggcat tttagttgcg ttagcgttaa tacctgaagc 177181 gattggcttt tctattatag ccggtgtgga tccgatggtc ggtctttatg cgtcattttg 177241 catagccatt attatttcta tttttggtgg cagacctggc atgatttcag ctgcgacagg 177301 ctcaatggca gtcgttatgg tgtcgctggt tgctgatcat gggcttcagt atttatttgc 177361 ggctacgatt ttgacaggca ttattcaggt gattttaggt atcagtaaaa ttgcaagatt 177421 aatgaaattc atcccgcgtt ctgtgatgat cgggtttgtg aatgcgctgg cgatccttat 177481 cttctctgcg cagcttcccc agtttgaagg tgcttcttgg agcatgtatg cgatgcttgc 177541 cgggtcgttg gttattattt atgtgctgcc aaggtttacg actgctgttc cgtctccgct 177601 tgtggcgatt attgtgatga caattattgc ggtcactttc catgtggatg tgcggacggt 177661 tggtgatatg ggcaatattt ctagttcatt gcctcatttc ttaatccctg atgttccgtt 177721 tacctttgaa acactgcaaa ttatttttcc ttattcaatt gctttagcgt ttgtcgggtt 177781 gcttgaatct ttgctgacag cacagattat tgatgaaatg acggatacgg atagtgataa 177841 aaataaagag agccgcggac agggaattgc gaatatcgtg actggattct ttggcggaat 177901 ggcaggctgc gctatgatcg gacaatctgt cattaataca aaagcgggcg gtcgcggacg 177961 tttgtcagca tttgttgccg gtgcttttct gatgttttta attgcggtgt taagtcatgt 178021 cgtggtgaaa atcccaatgg cggcgttagt agctgtaatg gttatggtgt ctgtcggcac 178081 ttttgattgg tcttctttaa aaggtctcaa aaaagcgccg ctcacggact cgattgtcat 178141 ggttgtgact gtggttacgg ttgttgtgac ggatgactta tctaagggtg tatttgtcgg 178201 tgttctttta agtgccgtgt tctttgtagc aaaaatctcg aagctgaaaa tcgtttctca 178261 tgcagaggat caaaagctta gaacgtatca agtgaagggg caaatctttt ttgcgtcagt 178321 gactgatctt acgaatgcgt ttatatatca agaggatatt gagcgggttg tgattgactt 178381 aactgaagct cacgtatggg acgattctgg tgcggccgca cttgataaga ttgttgcgaa 178441 gtttaaggaa caaggcattg aagctgagtt aaaaggtttg aataaagcga gtaaatctct 178501 aatgaaacag atggcataaa atagagaagc ccagatgaat gagatctggg cttttttata 178561 taacatacac ttaagcagca ttgatataat agagagaaga gaaattttaa ataggggact 178621 tgcatatgat gcttcagaag ctgaaccgtg tattggggag agtgatgccg ctgttaacgc 178681 cgactagtgt ggtgctgggc gtgctgctgt ctcagttttt aaatgggtat gaatgggctg 178741 tgccttggat ctttgctttt attacgtttg caggcagttt gagcgcgaac tttcaatctt 178801 tgagacatgc attgtctcat cctctcccta tgattcttgc actattcgtt cttcatattt 178861 tcatgccgct ttttgcttgg ggcagcggcc atcttatatt taaaggtgat cctttgacga 178921 ttaccggttt aacattggct gttgtgattc ctacggggat tacaagcttg atttgggcag 178981 cgatgtacaa agggaatgtc ggtttgacac tttcgattat tttagttgat actgtgctgt 179041 caccgctaat cgtaccgctg agtctttcat tgctggccgg cgctcaggtt cacatggatg 179101 tgtggggaat gatgaaaggt ctgattgtaa tggtcgtgat tccttctttt ttgggcatgc 179161 tgtttaatca gatgtcatct ccagaaagaa ctgcgtttgt gagcagtgcg ctgtcgcctt 179221 tttcaaagct ttgcttgatg gcagtgattg cgattaacag ttcagcgatt gctccttatt 179281 tcaaatccat tgatttgaga tttgcaggaa tagctgtaac ggtattcttt atcgcgttaa 179341 caggttatgc cgctgcttgg ctgatcggaa aaatgatgaa aaggcggcaa gaggaaatag 179401 tctctcttat atttacggga ggcatgagga atattagtgc cggcgcagtt cttgccgtta 179461 cgttcttccc gtctcaggtt gccgttcctg ttgtgatcgg catgctgttt cagcagatat 179521 tggctgcttt gtttggctat atgctgaatc gttttgaatt aaaaccaatg ttgcagaagg 179581 cataaaaaaa ccgctcatag ggttgagcgg ttttttccgt atagccattc gagcgcgttg 179641 atgaactgtt tgcagaaata cttgtggtgg tgcaccgctc ctttttcaat tgaaagacac 179701 aactggtctt cagtgaagcc tttttctttt agactttgat gaacttgctt tgtttttttc 179761 agcatatgtc gctgaatgga ttgtttttca cggccttctt cactcccgat agacatgaaa 179821 acacgtgcag tgccgggctt taaagaagat atatgaatgg tttccgctgc gttctcgtac 179881 cagtatgaac ctgatataga gcctattttc ccgaacattg acggatattt taatatggcg 179941 aacattgaga tgaggccgcc taatgaggca ccgatcattc ctcttgactg cggttccctg 180001 gtgacgttcc agttttcttc gattagcgga atgaactggt tcgttatatc agacagatag 180061 tgatatccca ttccgccgaa gtccgtgaac cgatcactga gtgatgcagc cggccatggg 180121 gtgtattcat caagccggtt ttcgggttcg ataccgatca gcacgagttc agggagcctt 180181 tgctgttgaa aggcgctttc tagtaattcg atttggtttt ggaacaaaga actgccatcc 180241 tgcacgtaaa cagcaggaaa tcccccgctg tctgtgctgt aggaaggagg gaggtacagc 180301 gtgaacctcc tgttgccggc tttgtgttct gaaagagatc ctttcaagca ttctccccct 180361 ttttttgctt gaaaagcaga tataagaaat aaggaactcc gaggatcgcc aaaatgatgc 180421 ctgcgggcac ttctgcgggc tgaaaaaaca gttttccggc aaagtctgcg cttatcacaa 180481 gaagcatccc gattaaaccg ctcagtggca ggatatagcg atgttcgacg ccagccagtc 180541 tccgtgagat atggggagca attaagccga caaacgccat acttcccgct acggagacac 180601 aggcgctgat gattgctaca caggcaacga gaaggatggt tttttcttta tttgatgaaa 180661 taccgaggct tctgactgtg tcttcatcaa aacgaatggt gtcgagcagg cgggatttgc 180721 cgataagaat cggtataaac agcagcatcc atgggagtac agctgtaata tacgtccagt 180781 tggcagacca gatgcttccg tttttccaca ccatggccat ttgatagtct tgcgggtcca 180841 tttttaaaga taaaaacaaa gacagggcgc tgaatcctga attgatcgca atccctacca 180901 aaataattct tcctgaatct aaattgcctc tgtgccatgc aaatatgtaa atcaggatcg 180961 ccgcgatgag cccgcctatc aatccaaaga gcggcattcc catcgctgca gctatggatg 181021 tcacttcctt ctggccttgg aataagagca taaacgctac aatgccagct cctgcccctg 181081 cgttgattcc gagaattcca gggtcagcaa gcccgtttct cgtgatggcc tggataacag 181141 cgcctgcaat gccaagaccg agtccaataa tagcagccat gacaacccgc ggcagtctta 181201 aatcgaacag caaaatttca tactgcggat tcgggtcgat ttgaaaaaga gtggagagca 181261 gctcagcagg acgaacagaa aatgatccgc tcgttaagct gaaatagctg acaacaagaa 181321 tcaaagcgat gaacaatgca tattttttag ccattttgct cccctccttt tcgtttaatt 181381 aaataaagga agaaaggtac gccgataatg gatgttacga cctcaatcgg tgtttcaaac 181441 ggatagttga taaatctgct tgcgagatca cacagggtta aaaagattcc gcccaaaata 181501 caggaacacg gaatcagcct gctgtaatca gagccgacga gaaatctcgt gatatgcgga 181561 acaaccaacc cgacaaacgc aatttttccg gccagcgcta cggcactgcc ggttagaatg 181621 atgacggaaa gcatcgccat gattttaatg gtttttttct tttgccccag gcttttagaa 181681 atgtcgtccc ctaatgatac agcggttacc tttttgctga gagaaatggc cattataatg 181741 ccaatcagga aaaacggagc ggcaagcttc aggaaatctg gactcatttg atgaagtctg 181801 gcactgtacc agaaactgag atcctgagaa atttgaaaat aaatcgacat ggccgctgat 181861 aagctgctga gcagcatgct tgtgactgtg ccgatgatgg cgagctgcac gggggtaaat 181921 ccgtttggca tcatggcggc aaggccgaat actaacaccg ctcctaacgc tgagccgata 181981 aaagagtata tcatcatttc aatcgaagat gattgcggga gcagaaccat gcaaagcgta 182041 atgataaacg ctgaaccatc tgaaacaccc ataatggatg gcgaagctaa ataattgcgc 182101 gtaatgccct gcataagcgc tccagaaaca gcaagggctg cccctatgag cagagcgccg 182161 gcagcccttg gaatccggga atgccatata atttgatggt ctgtgtttcc cggatcgaaa 182221 tgaataagag atgtaaaaac aatatctgtg ctgagatgct ttgccccata aaggattgaa 182281 agcaaaagtg acagcgctat agcaaatgga gaagtaatca atatgatacg tgtccactgt 182341 tttgaataca tacaaaaacc tactctgaat tagttttgtg tcaatttttc agcagccgct 182401 ttcaggaaac ggactttgct ccaagctgtg ccgccttgtg cgagagggtc cactgagttg 182461 acatacacat ggtcttcttt gactgcttta aggcttttcc agattggatt tttctctaaa 182521 tcttttaagg catcaggttt gtctgcattt tcatcatcag aaaattggac gaaaatatgg 182581 tccgggttca tttcacttaa tttttctaat gaactcagct cttgcgcttt tgcagccttt 182641 acttcgttcg gcgccttaag gcctaaatca ccgtatagtg tggagttgaa atacacctgt 182701 tcagggtaaa tgtaaatgtt gccttgtctg attctgatga caagcgcttt tgaatctttc 182761 gctttatcgt tgatttttgt ttttatttct tttagatcct gttcatagtc tgcaataatt 182821 ttctttgctt ttttctcttt tccagtcagc tgggcaagaa gcatcatgtt ttccttccag 182881 tttgaagaga tatgagaaac tgggatcgtc gtgcctgctg tgctgatttt ttgcagcgtt 182941 ttttccggaa actttgttga agcaaggata acatctggct tcatttcaag aatcttttca 183001 atatttggct ccattttttc tccggttggt tcggctttat cagtgatgtc tttgaacata 183061 tcagggaatt tgccggagaa tgaaattgcg ccttgcggat gaacgtcaag caatttcgcg 183121 tcttccattg attcaacgct tcccgtaatg gcaattttgt ctgtcggtac agttacttca 183181 tatgttttat caaggtattc aattttcttc ttctcagatg ctgtgccgct tgccttgctg 183241 gcagttgatt catttttgct gccgcaagct gccgccgtca gcgcgagaag taagattaat 183301 aaggtaagag atatcttttt catctataga gcctcctgtt caattgataa ctattatcaa 183361 ttggaattat agagaatgaa cagatataac accatggaca aattcctgat ttatcatgga 183421 caatctccgg atagtaaaga aacagtttgc tgaacgatgc gttcgtgccc gcaagctgag 183481 tattcattcc acgggtcaag ggatagaaga taaacacggt tatctcgtac cgcgcttagg 183541 ttttgccatg cttctgtctg ctgtaattgc tggtagtaag ctatggtctc cggctcttta 183601 aaaagaaaaa gcatcataca gtcagcttgg taatttgcga tattttctaa cgaaatcgct 183661 tgttctgaag gtgtgtcagc cgttgttgcc gagctgaatc ctaaatcccc aaagaaaact 183721 tcgcggacac ttcggttatg agccagatag aagttttgct tatgcagcct caaaaagaga 183781 aaacgcagcc cttgaacgtg ctgaagtgtt tttttggcgg ccgttgtctg ctggtcataa 183841 tccgctagcc acttttctgc ttcggactcc tcctttaaaa atgaggcagt ttgcagaaag 183901 tgggttctcc agctttcttc tgaaggaagg tacatgactt ctgcgatgcg attcaggcga 183961 tcttgttctt ctggagaaat agaatccatg ctgacaatca catctggttc tgcctgtgat 184021 aacgtgtaca ggttttcttc ccacttttca ttaaaccggt atgcactgag ctggacgggt 184081 atatctgtcg aataatgctg atagtagtaa gacgtccatt tcggatgcag agcggccgca 184141 aaaggtatgt ggtgaagagg gatgagatgg cccattgtgc cccttccgta tgcggcgatt 184201 ttctttcggc gttttttcat atagcttgta ggtgaacagc ctgtatattt tttaaagatt 184261 ctgctgaaat aaaattcatc ttgataaccg gtttggtgtg cgatttcttt caatttgcag 184321 tttgattttg ccatgagccg ttttgccttt gtgattcgtg ttttcgtaat aaattctgtt 184381 acgctctgtc ctgtccattt tttaaagctt tcactgtagt gtttggcact gattcctgcc 184441 atttgcgaca gctgggcaag cgtgattttt gtatcggcat gggtttcgat atagtgtttt 184501 gttttttcga ttgctgaatg tgtatccgtt tgatcagata aactggcagt aaaaagatca 184561 taaatcaggc tttgtacttc aatcacacat tttagctgag aaagctgaga cgattcattc 184621 catagtgcgg caagctcttg aagccggact gcaagatttt cgatatgtga aacattcata 184681 agcttcagtt tggctaattc cgattctgtg cacggtgtga aaatatcttg cccggtttcc 184741 ttgatatagc ttagaagcct gattatacag gcatctatat gtccatcggc tgctggcgta 184801 aagccaaagg tctcgttagg cggacaaaca taaagtgtct ttttttgcag aggattggtg 184861 tttgttccga tcgaaatata gccgtttcct tttaaatgaa aaatcagcac gaatgaatcg 184921 gctaattgct gttctgagaa gagatcactt gtctttttta gatattcaat ttgtactggt 184981 tgataaatca ctgcattttg cacgagtaga ccaccttttc agaagctttc aattgataat 185041 cattttcaat aaaaattgta ccaaataaat gaaagttttc ctatataaag cgggtgggtt 185101 tttagcatga aaaaaaccct tacttatgtg taaaagtaag ggtctttcgt tcaataagaa 185161 tatgttacac gtgtaacata cgatgcttat gttctaataa atgagatact tttttcttgt 185221 tttgctgaat tgttggagtg ttttttcata gctgtttatg atgttctcaa ccgaagttcc 185281 attttcaatt tttgtcctga tccagccgtt gcctgccagt ttatcgaatg aacctgttga 185341 caggaactca aaatcctcag gatagagatc gtgtatggtt ttaatgactg aaagacccgt 185401 tttaacggct tcaaacttat ctctgtctgt cacatagagc tgcacaccgt ggcaaagcgt 185461 tccttgatgt ttagaaaacg tcggtgtgaa ggatgctgcc ctaaatgtaa cgcccggcaa 185521 atggaggctg tttaatgttt cttcaagttc tgtgcttttg ataaagggag ctccgatcaa 185581 ttcgaatggc tttgttgtcc ctcgcccttc ggatatattt gttccttcaa tcagcccggt 185641 tgcaggataa acaaatgtgc tttccaccgt cggcatgtta ggcgaaggga ggacgaaagg 185701 caatcgggta tcgtcaaaat ccatttttcg tttccagtgt ttcattttta ccactgtaag 185761 atcggcatca atactaaatt ctttgttgaa cagtgaagcc aattcgccta tcgtcatccc 185821 atgcttcaat ggaatgggat acaatccgac aaatgaggcg tattcaggtt ctaagattgg 185881 tccttcaata tgattcccgc cttgaggatt cggacggtcc agcaccataa atggaatgcc 185941 gttttcttta gcggcttcca ttgcgtatgc cattgtataa atgtacgtgt agaaacgggt 186001 cccgacatcc tgaatgtcaa acattagaat atcgacattt ttaagcattt ctggagtcgg 186061 ttttttcgtt tttccgtaga ggctgtatac gggaaccccg gttttttcgt caatgtaaga 186121 gcctacttcg tctccagcct gggcgtcacc gcggacgccg tgttcagggc cgaataaagc 186181 tgtcagtttg atatccgggt tctcgtaaag gatatcgaca ctgcttttta gagatgtgtt 186241 tactccggct ggattggtga tcagtccgat gcgttttccc ttgagctgtt ttttatagtc 186301 tggcaagagc gtgtctatcc cagtctggac tttaggtttt ttagctgttt gattctttga 186361 atcgggtgaa gcagaggcag cggttatcgt tccgaacatc atgagccctg tcagaaaagc 186421 gaatattgtt tttctcatgt gtccctcctt attaaagcgg tcttcccgtt ttgatattta 186481 atccgtagcc aagtgggtaa agggtgttcc ctggtttcgt gactgacgga atgtcaactg 186541 gaagtgtgcc tttaggtttt gcctggccga atatcgccat cactccggcc ggaatattag 186601 gttgaagata acggccattt gcgtatcctt taaagccata gactgcaatc agtgcttttg 186661 cttcttcgaa attggctgcg tcataggggt tgcgcaggct cattaagaca aatggtttgt 186721 tgtgctgcag tgcggctttc atgacagctc tcggaaacac ggtggcccat ttgcttgaat 186781 ctgatattgt gtcgtcgatg acaccgtcgt tgacgacagg gtcatttttg acgacatagg 186841 agccggtaat gatataatca gcctctttta cttgtttttc atgctcggtc ttaaatactt 186901 ggctggcaaa gttcattttg ctgagggata cgggtttgat tttctttcgc ttgatgagat 186961 cgtgaatggt ttgttcgatt gaagcagttt gttcttcgta aggtgccaca attaagattc 187021 ggctgccttt tttaggcttg aacggcaaag tgtgctgttc attttttaat acagttactg 187081 ctttttcagc taattttttc tctgctttca ggtgctgctt gcttcctacg atttttttgg 187141 ctttggctat tttttctttt gtactgtcgc tgtttcgcgc tggatacatg ccgcgtttta 187201 ttttcaggga aatgattctt tcaactgaat tgttgatttg ttgttcagga atatccccgt 187261 ttttcacggc ttctttcaaa gcttgaataa cacgtgcgaa tttctgttct tctttcaatg 187321 aagtgactga ggctggcatt aatgcaatat cgacaccagc ttttacggcc atgaccacag 187381 cctcttcctg tccgaaatga tctgcgattg ccttcatatt gagcgcatcg gtaacgatga 187441 ccccattaaa gcccatttcc tgacgaagaa gacctgtcat cacttttttt gaaagtgtag 187501 ctggaaccag aatgtccgat ccatcgagtt tgcttttgta agtggtgtca tcaaaggcgg 187561 gaaactgaac atgggctgtc atcaccatat cagcaccagc atcaattgct ttttgaaaag 187621 gataaagctc gacctcacga agccgttctt ggccatggga aacgagcggc agtccataat 187681 ggctgtcaac gtccgtgtct ccatgtcccg ggaaatgttt gagggcagac gcgatatcct 187741 gccgctgcaa ccctttcatc gtatataaac cgaggcgtga tgtcagttct cgattggagc 187801 tgaatgaccg tacgccgatt acaggattat caggattatt gttaatgtcc acgacagggc 187861 tgaaatctgt attgatgcct aaggcagaga gctcttttcc gatgatgctg ccggtctgat 187921 acgcattgat tctgcttctg gctgcgccca gcgccatatt ccctgggaaa ttagtgccct 187981 cccctaacct cgttacaatg ccgccttcct gatcaatact cagcatgagc gggatttttg 188041 gacttgcctt ttggtaatcg tctgtcagtt ggacagtttg ttttgttgtt tttacatttt 188101 ctgcaaaaag gatgatgcct ccgaattgat atttcttgac gaggctggcg acttcatcat 188161 tcatttttgt aagggcttgc ggagaggact cgccttcctt ttgccaattt ctaaaatcag 188221 gcatcagcat ctggccgagt ttttcatcta acgacatacg attgacaatc tgattggcat 188281 cgattgcacg tttggatgca gaggcttctg tctgtctggc cccgaaaaag catgaaagaa 188341 agagaacggc tgaaaggata agcggaaaga caggtctcat agaaacttcc tcctatcgtc 188401 taatcattca ctccatcgct tcataaatcg cggttatgac acttccataa ctgcctgttg 188461 gaaattggtc accttcaaag acgttcggat tttcttccgg atcaataact ggtgtatgct 188521 ttttatttgt taacaatgcg atgcctaaat tgtatgctgg atcaataatt gtaactgtcc 188581 ccgtccagcc ggtatgcccg taagcatttt cgctggcatg agggccaaac atccattcca 188641 tgcttttact tccgttccgc ctccagccaa gagcgaatgt cggatctgtt gctgaaggtg 188701 ctgtaaacag gtcggctgtt ttctgatcaa ataaagaaat gtttcggtat gaacctttgt 188761 ttaacatgac ttgcagcagt atggccatat catctgcatt tgagaacaat ccggcatgcc 188821 cagacacgcc gtccattgag taaaacgctt tttcgtcatg cacctctcct tgcagcgtgt 188881 ttgtgcggat gttagggaat tgaataacgc cgtcacgtgt attgcccatg cgttcagtag 188941 ctgcgaactg tttcggttta aagccctttt gcagcggatt gtacaaggta tgcttcagcc 189001 tgagcggttt gtagagctct tgctccgtgt agacatcaag cggtttgccg gtgagttttt 189061 cgacaataca tccgagtagc atatatccaa tgtcactgta tacgtgtttt gtcccggttt 189121 gataatcgag cggaattttc gtcaaatatt caatcgtttt gtcccgttct tgggaatagt 189181 acttgccggc tttttccggc gtgtaaaagt aaaagcttga tgggagccct gattggtgct 189241 ggaggacatc aatgacacgt atcttgtctt ttccttttat gaggtcaccc ggctgatcct 189301 tgaaacccgg caaatatgca gaaacttttt catagacgtc aagttttcct tggctgacta 189361 agcgctgcaa tgcaaaattt gttgcgtaca tttttgtatt tgaggctaag tcaaacatcg 189421 tgcgggtttt cattttggcc ggacggcgca gcagttctga tccttcgtac tttttactgt 189481 agccgtatgc tgcttttttt atgatgcgtc catccttcac caccacaaga acggcgcctg 189541 gaaatcctgc tgcaatatcc cgttctatca tctgatctac cttccttagc ttcttcgtcg 189601 agaattgtgc agtttctgca tttatgattt tcggctcaat caagttgcct gctgtttgtg 189661 cgaaggtttc atttggcgca aatatcgata gggttaaaat ggcactgaat atgaacagtg 189721 tctttgtttt cacaggctag cccctttctg tgcttctatc ccgtttacta tccctaaaac 189781 agaaacaatt taatcgaact gagaagccat ttcatcttta tatccgaatg cataggtcaa 189841 taaaaaaccg gccgcgtagg aaataaagag cccaacgata tacaggatga tttgcgaagg 189901 caggactaga aaagatagcg gcagtccgga gacaccaatc gcaatggtgg ctacttgaaa 189961 ataagcttga aaggcgccgc cgattccagc tcctaaacat gctgttaaaa acggacggcc 190021 aagcggcagc gtgactccga aaataagcgg ttcaccaatg ccgagcagtc ccgatggaag 190081 cccgccggcg attgctttcc tcagtgttgt ttttttcgtc ttcacgaaaa cggcaaaggc 190141 cgcgcctacc tgtcctgcac ctcccatagc caaaataggg agcagaggat cattgccaat 190201 tgaattgatc agttccatgt gcacaggcgt caagccttga tgcagtccgg ttacgacgag 190261 aggaaggaag gttgcgccca gaataaagcc cgcagcgatg ccgccgatgt ccaggatgga 190321 cagtaggccg gatgtaatag catcagaaat gaatccgcct aaaggcataa atacgacata 190381 cgttacgatt ccggtgatta acagtgaaac ggtgggtgtg acaatgatat caagtgattg 190441 aggaataaaa cggcgaataa attgttcggt gtaagcaatg aatatggctg cgaaaaggac 190501 gccgatcaga cctcccctgc ccgggagaag ctcttctcca aataaactga tttttgcgat 190561 ctccggattg ataatcaaga tcccggccaa agccccaagt gcgggtgtcc cgccaaattc 190621 tttcgaagcg ttaataccga cgagaatgcc gagataagtg aacagccctg atccgatgac 190681 tgtcaggata atcgcaattt gtgagtctgc agagagccag cctgcttgaa taattgcttt 190741 ggtaatccca gtaattaaac cggaagcgac tagagcggga ataagaggga taaaaatgct 190801 ggcaatttta cgtaagaaaa gtttaaaagg agtggcattt ttccgattga tatcggcttt 190861 ctttttggcc gctgcttctt tgacatcggc accttcttct gctgacacga gctttgagaa 190921 agcagctgta acatgattga caactcctgt gccgaggata atttgtaagg tttcagcttc 190981 aacgaccccc aatacgccgt caagctttct taaagcctga gcatccgctt tgctttcatc 191041 gtaaggcgta atgcgcaggc gtgtcatgca atgcgtatat gaagaaatat tggattttcc 191101 tccgcatagc tcaaggattt tctgtgcgag atgatggtag ttattttctt tgctcattaa 191161 aacccctccc cttcaagatg ccttatttta ttctcataga ttgtatggct gctctcgttt 191221 tatctatata accggttgtc gtttcatact gctcagccgc catgcctaaa aacaaaacat 191281 caattataaa aagctgggcg aggcgggaag aagtggctgc acttcgaatc aaggcttcat 191341 tggaatgggc tgtatacaaa gggacatcag ccagtgcgga gacggatgtc tgactgaatt 191401 gtgtgaggct gatcgttgtg atgccttttt ccttagccat ggcgaacagt tcaacgattt 191461 cctgtgtctc tcctgaaaac gaaatggcga atacgatgtc gtctttatct gcatttgcga 191521 ttaaagatgc cacaagatga gtgtctgtaa acgcggttgc ttgtttatga atgcgaagcc 191581 acttttgctg ggcgtccttg gcgacaatgc cggaagcccc gaggccgata aaatgcacgg 191641 tatgagcttt gagaagcaga gaaaccgctc gttcaagctc tttgtagtcc atcaggtctg 191701 aagtatcctg aatggcttga atggcattgc cggccgtttt ttcggaaatg gagggcagcg 191761 gctcgtgggg aacaatatcc cggtagccct gaaacgtagg ctttgccaga tcgcctgcta 191821 ctctcatttt taaatcttga aatcctttta aaccgagtga tttgcagagc ctgatgacgg 191881 cagcgtcact tgaattggct aaggcgctga tttcgttgac cgtgctttcg attgctttgt 191941 ggggatgggc taggatataa tctgcaagtt tgcgctcgga tggagggagc ttatgcttca 192001 ttgattggat gatcgctaaa ccgcctgtgg ccattctagt tctctcctta tcatggatgg 192061 taatgttcga ttgctttgtc aatgaaaccg tttgcttcat cgagtaatgt ctgtgcttgt 192121 ttctgatctg tgcttgtttt gagcatgacg attgctgttt tgacgtgatg atcggcttgt 192181 tccagagtgt atctggctgt gtcgtatgaa gcgtttgtaa ggctttggat gatgctgatg 192241 gcgcgttctt ttagtttttt gttgctgacg ttgacgtcta ccatcaagtt ttcgtaaacc 192301 ttgccgattt tgaccattac agcggtagat atcatgttta gaatcatttt atgagcggtt 192361 gcggctttca tacgtgttga tcctgtaatg gcctcaggtc cgacgacaac ctcaatgctg 192421 tgatccgcat ccttgctgat ggcggaattt tcattgcaag taagggcgat ggtgtgtgct 192481 ccgactttac gggcgtatct tagggcgcct gcggcgtagg gtgtgcggcc gcttgctgcg 192541 atggcaatga cggtgtcatt tgaagtgagc tgtatgtttc ttaaatcttc agctcctgct 192601 tcttcactgt cttcaatgcc ctctgctgcc tgtaaaaagg cttcggggcc tccagccatg 192661 attccgatga cctgatctgg gcttacgctg taggtgggag gacattcaac agcatccatg 192721 acgccgagtc tgccgcttgt gccggcgcct gtatatatga gccggcctcc attttgaaac 192781 gattcatatg cgcagtctac agctgttttg atgtcgggga gaacctcctg aacggctgca 192841 gcgactttca tatcttcgtt gttgatcatt ttaaggatgc cgagagtgtt tgctttgtgg 192901 atttcaactg tttgactatt gcgtgattcc gttgtaagac ggtgaaggtt taatggttct 192961 gacatgagga tgccccctgt tttaaaatga tatatctcaa tattcagtat attcatttct 193021 gttatgatat ttcaactatg tttttaaatt tttgaaattt tatttcactt aagactataa 193081 gaaatgatga aggatcaact gttctccaag cggcccgatt cttcgccgtc ctttatcaag 193141 gaacccgctt ttcatataaa ggtgttttgc gcgtatgttc agatgattga cggccaagat 193201 gatttcgtcg caccatggaa aatatccgct cacaaaagcg ggaagcaaaa gcatggcttt 193261 tttcgcatag ccttttccgt gatgcacagc ggttaaagac agggagctga gcagtaaagc 193321 aaatggattg ttagaatagg aagcaagcgt ttcttttgat gcatgtaaaa tgaaaaaacc 193381 gactggaagg tcgtctttta agatgacaac cgggtatcgg tcctgtatgc ccagagcctg 193441 agacagcacc tctttcggga gggaggtaaa gcgtttgtca tcgttggtga gcgtgaatga 193501 ttggagctcg ggcaagtgtt caggcttata gaaggataaa gaaatgtctt gagtcatggg 193561 gtggcctcct tacaatatgt cgttaagctc gttttccgaa atgacgcggt agcccgcttg 193621 ttttaacagt gcggcggtta ctccgctgcc ggtgattttt ttgccagaga atgtgccgtt 193681 atagataaaa ccgcttccgc aagatggact gttttctttt aatatgacgg cagaagcgtt 193741 gatttctttt gcgtaagcca atgttttcgc ggcgccttcc atatatagtt ctgtgacgtc 193801 ttctcctgaa gctgtcacga ttttcgctgt tccattgagg acatcctcgc cagtgcctcc 193861 tatgatttct gcgggttcgc gtggggtaga gaagccgccg agaagttcag ggcaagccat 193921 gactgctttc ttttcatcga ctagttttct gattttctcc gacgctgcgt gagagccgtt 193981 atatctgcat tcaatgcctc caaggcaaga actgactaga atcatattgg tttctcctct 194041 cttgctttgc ttgtctctat cataaaataa atggctttag ttgggaggct ttttcagtta 194101 aaaaaggagt taaaaagttt gaaaataaaa aatttaattt tcctctttac aaacaggggg 194161 tgacctgtat ataataactt ttgtcagctc gacgagaaca caacggcccg ttggtcaagc 194221 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcaccat 194281 ttggaggatt agctcagctg ggagagcatc tgccttacaa gcagagggtc ggcggttcga 194341 gcccgtcatc ctccaccatc ttgccggtgt agctcaattg gtagagcaac tgacttgtaa 194401 tcagtaggtt gggggttcaa gtcctcttgc cggcactgtt ttttcaaaat tttatgtgga 194461 ggggtagcga agtggctaaa cgcggcggac tgtaaatccg ctccctcagg gttcggcagt 194521 tcgaatctgc ccccctccac cattattggg ctatagccaa gcggtaaggc aacggacttt 194581 gactccgtca tgcgttggtt cgaatccagc tagcccagtc acagacacct ttgatcaaaa 194641 ggtgtctttt ttcttttcgg aaaaatcatt ccaacttcta actgttcagt ctgtataata 194701 attttaaaaa tatgttaagg tagtttattc acgaattacc atctacaccc tgccaaaaat 194761 ttgataaact tattttataa aaaaattgaa accttttgaa acgaagctcg tatacataca 194821 gaccggtgaa ggcagaggtt agataaatat ggaaatgatg attaaaaaaa gaattaaaca 194881 agtcaaaaaa ggcgaccagg atgcatttgc ggacatcgta gatatttaca aagataaaat 194941 ttatcagctt tgctaccgta tgcttggcaa tgtgcatgag gcggaggata ttgcacagga 195001 agctttcatc agagcgtacg ttaatatcga cagttttgat attaaccgga aattttcaac 195061 ttggctttat cgaatcgcga ccaatttgac cattgaccgc attcgcaaaa agaagccgga 195121 ttattacctc gacgcagagg tggctggtac ggaaggcttg accatgtatt ctcaaatcgt 195181 cgcagatggt gttttgcctg aagatgcagt tgtatcgctg gagctctcaa acacgataca 195241 gcagaaaatt ttaaagcttc ctgacaaata cagaacagtc atcgtattaa agtatattga 195301 cgaactctca ttaattgaaa tcggggagat tctaaacatt cctgtgggga ctgtgaaaac 195361 gcggattcac agaggcagag aggctcttag aaaacaatta agggatcttt aagtggggtg 195421 atgaaatgag ctgtcctgaa caaattgtgc agcttatgca tatgcatctt gatggagata 195481 tccttccaaa agatgaacac gtattaaatg aacatctgga gacatgcgag aaatgcagaa 195541 agcattttta cgagatggag aaatccatag cgctcgtacg gagcacatcg catgtcgaag 195601 cccccgcgga ttttaccgct aatgtcatgg caaaattgcc taaggagaag aaaagagctt 195661 ctgtaaaaag atggttcaga acccatcccg ttatcgcagc tgctgcggta ttcatcattt 195721 tgatgggcgg gggttttttt aacagctggc ataatgacca caatttcagc gtgtccaagc 195781 agccgaatct tgtggttcat aaccatactg tgaccgtgcc agaaggtgag acggtcaaag 195841 gtgatgtcac tgtcaaaaac ggcaagctga ttattaaagg caaaatagac ggggatgtaa 195901 ccgtcgtaaa cggcgaaaag tatatggcct ctgctggaca agtcaccggt cagattgaag 195961 aaatcaatca gttattcgac tggacatggt acaagatgaa gtctgcgggg aaaagtgtac 196021 tcgatgcatt caatccgaac ggagaagagt aaagcgcgtt agccgctttg ctcttttttt 196081 gcgggctgag agggctggca catttcactt gctaaatcga aatgtggtat aatgggctcg 196141 ctatgtaaag tacatatgcg taacacgtaa aacacaaaat acgaaatgac tgaaatcttg 196201 gaggacgagg aaatggcttt tgaggatatc ccttttttgc agtacctcgg caatgccgtt 196261 gatattctcc ttgtttggta tgtgatatat aaattgatta tggtgatacg cggcacgaaa 196321 gcggttcagc tgttaaaagg aattgtagtc atcgtgcttg ttcgtatggc cagccaatat 196381 ttgggcctca gcacacttca atggctgatg gaccaagcga taacatgggg atttttagca 196441 attattatta tttttcagcc tgagctgaga agagcgcttg aacagctagg ccgcggccgc 196501 tttttttcga ggagcggcac gcctgttgaa gaagcgcagc agaaaacgat tgaggccatt 196561 acaaaagcaa tcaattatat ggcgaaacgc cgtataggcg ccctgctgac cattgagcgg 196621 gatactggaa tgggcgatta tattgagacc ggcataccac taaatgccaa agtcagctct 196681 gagctgctga tcaatatttt tattccaaac accccgcttc atgacggtgc ggtaattatg 196741 aaaaataatg aaattgccgc ggccgcctgt tatctgccgc tttctgagag cccgtttatt 196801 tcaaaagaac tgggcacgcg gcacagagca gctgtcggta tcagtgaagt aacagacagt 196861 ttgacgatta ttgtgtctga agagaccggc ggcgtcagtg tggcaaagaa cggcgacctt 196921 cacagagagc ttacagaaga agcgctgaaa gaaatgcttg aagccgagtt taagaaaaac 196981 accagagaca cttcttctaa ccgctggtat tggaggggca agaaaaatgg ataaattctt 197041 aaacaaccgc tgggctgtga aaattattgc tctgcttttc gcgctcttgc tttatgtggc 197101 ggttaacagc aaccaagcac cgactccaaa aaaaccgggt gaatctttct ttccgacatc 197161 aacaactgat gaagcaactc tgactgatat tccggttaaa gcgtattatg atgatgaaaa 197221 ttacgtcgtg acgggtgttc cgcaaacggt taatgtcacg ataaaaggct cgacaagcgc 197281 cgtgaaaaag gctcggcaga ccaaaaactt tgaaatatat gccgatatgg aacatttgaa 197341 aaccggcaca cataaggttg agcttaaggc caaaaacgtg tcggatgggc tgacaatctc 197401 aattaatccg tctgttacga cagtgaccat tcaggaacgg acgaccaaaa gttttcccgt 197461 agaagtggag tactacaaca aaagcaagat gaaaaaaggc tattctccgg agcagccgat 197521 tgtcagtccg aaaaatgtgc agattaccgg atcgaaaaat gtgatcgata atatttctct 197581 tgtaaaagct tcagtgaatt tggaaaacgc agatgaaacg attgaaaagg aagcgaaagt 197641 gactgtctat gataaagacg gaaacgcgct tcctgtcgac gtggagccct cggtcatcaa 197701 gattaccgtt ccggtgacaa gcccgagtaa aaaagtgccc tttaaaattg aacggacagg 197761 aagccttcct gacggtgtca gcatagcgaa tattgaatcc agccccagtg aggtaacggt 197821 ttacggctca caggatgtgt tggattctct tgaatttatt gacggcgtca gcctagattt 197881 aagtaaaatt aacaaggatt ccgatatcga ggcagatatt ccgcttcctg acggtgtcaa 197941 aaaaatctca ccgtcaaagg tgactttgca tatagaagtc gatagtgaag cggatcagaa 198001 gttcgagaat gtccctatca agactgtagg gctgagcagc tcacaaaaca ttgaatttct 198061 tgatcctgaa tcacaagcga tagatgtaac ggctaaaggc tctcccacga atataaataa 198121 actgaaaaaa tcagatattg aattgtatgt gaatgtttca gatttagagg acggggagca 198181 tagcgtgaag cttgaagtga acgggccaca gaatgtaact tggtccttgg ggcggaaaaa 198241 cgccaaaatc aagctgacgt ctaagaaaag caatacatca acgaatgata acagcagcaa 198301 tacatcaggg aaccaggaca cagataaaca aacaaatgat caaaagaaca atcagcaaga 198361 agatacaaag aacactgata aaaacaacaa cgatcaaaac caagacggaa ataaagatca 198421 aaaccaagat caggatgagg atgaatccac tgcgaattca caatcctcat cggaataaaa 198481 aaggagcgat tataaaatgg gcaagtattt tggaacagac ggtgtaagag gtgtcgccaa 198541 tagtgagctt acacctgagc tggcctttaa agtcggacgt ttcggcggtt atgtgctgac 198601 aaaagacaaa caacgtccaa aagtgctgat aggccgcgat acacgcatct ccggccatat 198661 gctggaggga gcccttgtcg ccggactttt atccattggc gcagaagtca tgcgcctggg 198721 tgtcatttct acaccaggtg tatcttattt gacaaaagcg atggatgcag aggcgggcgt 198781 catgatttcc gcttctcata acccagtgca ggataacggc atcaaattct ttgggggaga 198841 tggatttaag ctttctgatg aacaggaggc tgaaattgag cgcctgatgg acgaacctga 198901 ggataagctg ccaagacctg tcggagcaga ccttggactt gtaaacgatt attttgaagg 198961 cggacaaaaa tatctgcaat tcttaaaaca gacagctgat gaagatttca caggcattca 199021 tgtggcattg gactgtgcca atggcgcaac gtcatccttg gcgacacacc tgtttgctga 199081 tttagatgca gatgtttcta caatggggac ttccccgaac ggattaaaca ttaatgacgg 199141 cgtcggttcg actcatcccg aagcgctcag cgcgtttgtc aaagagaaaa acgcggatct 199201 cggtcttgcg ttcgacggtg acggcgaccg cctgattgct gtcgatgaaa aaggaaatat 199261 tgtagacggc gaccaaatca tgtacatatg ctcaaaacat ctgaaatcag agggccgttt 199321 aaaggatgat acagtggttt caaccgtgat gagcaacctc ggcttctata aggcgctcga 199381 aaaagaaggc atcaaaagcg tgcagacagc tgtcggcgac cgctacgtag tagaagcaat 199441 gaaaaaagac ggctacaacg tcggcggaga gcagtcagga catcttattt tccttgatta 199501 caacacgaca ggggacggat tattgtctgc tattatgctg atgaacactt taaaagcaac 199561 aggcaagccg ctgtcagagc ttgcagctga aatgcagaag ttcccgcagc tgttagtcaa 199621 tgtgagagtg actgataaat ataaagttga agaaaatgaa aaagtaaaag cagttatttc 199681 tgaagttgaa aaagaaatga acggcgacgg ccggattttg gtgcgccctt caggaactga 199741 accgctcgtc cgtgtcatgg ctgaagcgaa gacgaaagag ctgtgcgatg agtatgtcaa 199801 tcgcattgtt gaagtcgtcc ggtcagaaat gggattagag taacgaagtc tattatcaga 199861 gagtgaacaa gacaagcgag gtttacataa gataattgtg agacatacgg caaagttgct 199921 taaaaaacaa ttgaccgttt atgccacatg ttgtaaaatc aagcttgtct tgttcttatt 199981 ttctcaatag gaaaagaaga cgggattatt gctttaccta taattatagc gcccgaacta 200041 agcgcccgga aaaaggctta gttgacgagg atggaggtta tcgaattttc ggcggatgcc 200101 tcccggctga gtgtgcagat cacagccgta aggatttctt caaaccaagg gggtgactcc 200161 ttgaacaaag agaaatcaca tgatcttcca aaaaacatgt aggaggggac gattgaaagt 200221 ccccttgaaa tttgactttc ttcgtctcct tttacaatct taggaggaag aaaaatatgt 200281 gtggaatcgt aggttatatc ggtcagcttg atgcgaagga aattttatta aaagggttag 200341 agaagcttga gtatcgcggt tatgactctg ctggtattgc tgttgccaac gaacagggaa 200401 tccatgtgtt caaagaaaaa ggacgcattg cagatcttcg tgaagttgtg gatgccaatg 200461 tagaagcgaa agccggaatt gggcatactc gctgggcgac acacggcgaa ccaagctatc 200521 tgaacgctca cccgcatcaa agcgcactgg gccgctttac acttgttcac aacggcgtga 200581 tcgagaacta tgttcagctg aagcaagagt atttgcaaga tgtagagctc aaaagtgaca 200641 ccgatacaga agtagtcgtt caagtaatcg agcaattcgt caatggagga cttgagacag 200701 aagaagcgtt ccgcaaaaca cttacactgt taaaaggctc ttatgcaatt gctttattcg 200761 ataacgacaa cagagaaacg atttttgtag cgaaaaacaa aagccctcta ttagtaggtc 200821 ttggagatac attcaacgtc gtagcatctg atgcgatggc gatgcttcaa gtaaccaacg 200881 aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgatgaccaa gttgtcatca 200941 aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt gatgccagtg 201001 atatcgaaaa aggcacgtac cctcactaca tgttgaaaga aacggatgag cagcctgttg 201061 ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtct gtgcctggcg 201121 atatcgctgc cgctgtagcg gaagcggacc gcatctatat cattggctgc ggaacaagct 201181 accatgcagg acttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg ccggttgaag 201241 tgcatgtagc gagtgaattc tcctacaaca tgccgcttct gtctaagaaa ccgctcttca 201301 ttttcctttc tcaaagcgga gaaacagcag acagccgcgc ggtactcgtt caagtcaaag 201361 cgctcggaca caaagccctg acaatcacaa acgtacctgg atcaacgctt tctcgtgaag 201421 ctgactatac attgctgctt catgcaggcc ctgagatcgc tgttgcgtca acgaaagcat 201481 acactgcaca aatcgcagtt ctggcggttc ttgcttctgt ggctgctgac aaaaatggca 201541 tcaatatcgg atttgacctc gtcaaagaac tcggtatcgc tgcaaacgca atggaagctc 201601 tatgcgacca gaaagacgaa atggaaatga tcgctcgtga atacctgact gtatccagaa 201661 atgctttctt catcggacgc ggccttgact acttcgtatg tgtcgaaggc gcactgaagc 201721 tgaaagagat ttcttacatc caggcagaag gttttgccgg cggtgagcta aagcacggaa 201781 cgattgcctt gatcgaacaa ggaacaccag tattcgcact ggcaactcaa gagcatgtaa 201841 acctaagcat ccgcggaaac gtcaaagaag ttgctgctcg cggagcaaac acatgcatca 201901 tctcactgaa aggcctagac gatgcggatg acagattcgt attgccggaa gtaaacccag 201961 cgcttgctcc gttggtatct gttgttccat tgcagctgat cgcttactat gctgcactgc 202021 atcgcggctg tgatgtggat aaacctcgta accttgcgaa gagtgttact gtggagtaat 202081 aattaattaa cccctttgga taagaaggtc ttcacatgtg ctgctaggct ccaaatgtac 202141 acctttccgt aagggcaaag tcaaatgtga aaaaaaactg ttccaaagtt aatcagaaat 202201 ttattttcat attgtatcct tcggtatcaa gtgaaaggag catcatatga aaacattatg 202261 gaaagtcctc aaaattgttt ttgtcagctt ggctgctttg gttttgcttg tatccgtctc 202321 ggtatttatt tatcaccatt tccagctaaa taaggaggcg gcactgctga aaggtaaagg 202381 cacagtagtc gatgttgacg gtaaaaagat gaatgtgtat caagagggaa gcgggaagga 202441 tacgtttgtg tttatgtccg gttcgggtat tgctgcgcct gcttatgaaa tgaaggggct 202501 gtacagcaag ttttcaaaag aaaataagat tgctgttgta gatcgggcag gttatggata 202561 cagtgaagtg tctcacgatg acagagatat tgatacggta ttggaacaga cgaggaaagc 202621 gcttatgaaa agcggaaata agcctcctta tattttaatg cctcattcga tatccgggat 202681 tgaagcgatg tattgggcac agaaatatcc taaggaaatc aaggccatta ttgcgatgga 202741 tattggattg ccccagcagt acgtcacgta taaattgagc ggagttgacc gattgaaagt 202801 gagagggttc cacctgttaa cctcgattgg ttttcatcgg tttatacctt ccgctgtata 202861 taatcctgag gtgattcgac agtcgttttt aactgatgaa gaaaaagaaa tctataaagc 202921 cattaacttt aagcaatttt ttaatgcaga tatggagcat gagcttttac agtcttacca 202981 aaacggcagc aaatctgtga atctgcctgc gccaaaggaa actcccgtct tgattttaga 203041 tgcagtctct gaccaaaata gacattcaaa gtatgctata caaaaccgaa aagactatga 203101 agcgtttgcg gctcaattca atactgccga tataaaggaa ctgaggggaa cacacagtat 203161 ttatttatat cagcctgatc aaatatataa actgtccatg gagtttatga gaaaggttcg 203221 ctaggatgaa gggttatcgt attttaatcg ttgaggacga tgtgatgatt ggtgatttgc 203281 tgcaaaagat tttgcagcgc gagggatatc gtgtgatatg gaaaacagat ggagcggatg 203341 tgctttcggt gattcagaag gtggatttgg tcattatgga tgtgatgctg ccgggtgaag 203401 acgggtatca aatgtctgca aaaatcaaaa agctggggct gggcattccg gttatttttc 203461 tctcagcccg caatgacatg gacagcaagc ttcaaggttt gcagatcggc gaggattata 203521 tggtaaagcc ctttgatccg agagagctgc tattaagaat gcggaatatg cttgagcatc 203581 attatgggac ctttacgcaa atcaaacatt tgtatattga tgcggtaacg aaaaaagtgt 203641 tcaatgaaag cctgcatgat gaggtattat ttactgcgat tgagcggaaa attttctttt 203701 atttatatga aaatagagac agtatcctga caaaggaaca tttctttgaa tatctatggc 203761 agctcgaaga tagaaacccg aatattgtca atgtgcatat taaaaaaatt agagctaaaa 203821 tcaatgatca agcgggtgag atgattgaaa atatatatgg agaagggtat cggctgaata 203881 ccgttgtgaa gaaatgaagc tcaagacaaa atatcagttg ttattgttta cggccgtcat 203941 tagtgttccg atgctattgc tggcggtcag tgttttgatg tcggtgattt atgacagcat 204001 gtttaaaccg atgaatcatg gtatgccctt tcacaggtcg tttgcatacc cggcaatgat 204061 cgttgtattt ttgatatcac tcttattgtt agctttttta ttttcaaagt cgattcattc 204121 tctgttgcat aaaatcaatc tattaaatca aaccattcgg catttggcga gtgatcaaag 204181 ggtgcccgat aaaattgaag tgaagcgtgc tgatgaaatc ggggaactga tcaagtcggt 204241 caatttgtta attgaacgga cgacatatcg tgaactggag ctgagacagc aggaggaaat 204301 caaaaaggag cttttgcaaa aactgcggca tgacattaat acacctttaa cggctctcag 204361 gctgcagtta ttttatttgg aagaccaatg tcatggtcag gctgtattcg aatcattgta 204421 tcagcaaatc gaatatatct cggaattaac taatgaattc aatctatatt ccgctgagac 204481 gctggaaagc tcttatattg taaatgaaga agtgcgtcta aacgagctat tagaaacagc 204541 ggtgaaaaag tgggattatt tatacagtat gagtgggatt gagctgcact ataagccggc 204601 agatcaagat gtgatatgga tgagcaacac gttatggatg gaaaggctgt ttgataatat 204661 ttttcaaaat acgttaaggc attcaaaagc taaaaagatg gaagtcacga ttgaacatgg 204721 cgatgttttt attcgtgatg acggtattgg atttgatcgg aatgagagca gtgagggact 204781 tgggttaaag attattgagg atacatgcag gctgcttgcg attacttatg agctgcatac 204841 aaatgataac ggaacggggt tcttgttttc aaaagagtga ccccgctgat gtttttcttt 204901 ctcctataaa atttatataa tagggagaaa gaaatggggt gaacatcata tgtttaaaaa 204961 aatcatcaaa acgattaagt acctctcaag cagttctagt gaccgatatc gcagacaccg 205021 gcattacagc agcagccggc gcagacatta tcgcagctac agcagcagtt cgggcaaaag 205081 aagacactac gaccgttatg gcggcagtca tcgttacaaa cgccggagct acagcagcag 205141 ttaatccaaa aaaagttctt gttccgcttt tgggacaagg gtttttttat gtgaccgatt 205201 gaatggcccg gtttagatcc tcgcgaatgg aagcggtgtg ctgatactct tcctcaatgc 205261 ccaataatct tttcagcagc aaggttactt cctttgtcag tgttaattcc tccagccaag 205321 tgccgttttt cttctttttt cctttatatt gagagtacag caagaataac agcgtttctc 205381 cgagatcgaa gaagtcatcc tgttttcgta cctttatttc ctccatttct tcaggagtca 205441 attgtttggc aaggccgaaa tcgatgaggc agagcctgcc atcattgatg atgatattag 205501 gcgttctgat gtcgctgtgg aagataaggc gatcatgcag gtattctata atctcaagca 205561 gctgcgaaat cagttgtaac gccataagct ctgtgaacgg ctgttttcga aaaaataata 205621 attcttctat attctctccc tcaatgaact gcatgacata ataagcctgt ccgtctatga 205681 tgaattcatc tatgaagccc ggaatttgcg ggtggtgaat gtttttgagc agttttattt 205741 cctgctggaa tcggactttc tctttttcct ttttggcttt tgtcggccga agctgtttta 205801 agacataagg tgtttgagct aggatatcgg tgcacaaata aaccaaaccg tagcctccca 205861 taccgaggca ctcttcgatt ttgtattgat gatttaagat aacgccgttc tttagagggc 205921 ggtcaaatag cagttttttt agaagtttta atgccatgtc tgcacttccc ttggttgtac 205981 tgactatagt ttaccttcta gacggagaat aaaaaagagc cggataaccg gctcggtata 206041 agttaaaact gctttgtcac gtcgtattca taatctattt ttgcttttac gttgctcatc 206101 gtcgatctgg ctgtcgctaa tgtattatat ttaaaactcc atacctttgc cacactgagt 206161 tgatccgaca aagagatatc ataagaccct gaagtcgagc tgtttacaag ggcacggctc 206221 cattcgttat tttcgcttgt catgatcaga tggcgtgtat ttccctggct tggtgtttga 206281 gtggcggttg tttgaactct ggttacaatg gcatcacgcg gtatcccaga ttggtttgtt 206341 aaatcaacct tgatcacgct ggagtcagaa cctgaggggc taaggcttgt atttccttta 206401 ttttcagcaa cgccgctgaa ttggaacgtt ccgctgcctg atttgattcg gtcttcaatt 206461 gaaagcgtaa agtacatgtt tccagtatag gtgcctcgtg acactttcac atagaaggta 206521 tccgtcgtgt tttgggcgtc tgcatttgca taaataaaag aagaaaacgt attagggtta 206581 ataacttctg tcccttgaga aacaggtatt ctgttcttgt cataaatttc aattttcatc 206641 cctgtatacg cgctctggta tgtactcctc atgtatactt tttctccctt attagccgta 206701 aaagtgaaat aggcttcatc ttgaccagct tccagtattg ttgtatcgat atttttatat 206761 ttccaataac cgatcggcat tgcggtatca aatgaattgt ttcctgtgat agcagtgact 206821 ccgacagctg atgccgaata cgtaaaggta gataagacag aaagcataac agcgaattga 206881 ataagccatt ttttcaccat gcaaacaacc tccttttatt tccatcatac ataataacga 206941 tttaggtgta aataaatgtt ttttgaggtt aatatataca ttatattcgc cgataaaaaa 207001 gaataagaga gaatactcgg gagggaattc aatgcgtctg aatcggcaat ttatccgcac 207061 tcagctgatt gcacagaaca tattgagcaa gaatgcgcct gccaaacggg agaatgcgac 207121 tgaaaatcca gcggcagttc tggaaaaggc atatagcagg cttaagtcac aatcttcaac 207181 tgggggaatc aatcagttca attattctaa aaccagcgtg tcgggaaaca gcgggacgtt 207241 cagcaaagtg tatcaatcag cgaatgatcg aacagtgaca gacacagggg aagaaacagt 207301 gattcaatcc caaaacccct atgaatctga gagtgatatc agaatcaaaa tactagatga 207361 aaaatacagc aggatgaatg cgattaataa aacaaagtct gatccattag gctatattaa 207421 ggataagtac caaaattcaa agtctcctta tttcagaagt gatctgtcag ctgcagaaag 207481 acaggccgct tacgataatg aaacagaatg gttattcaaa gggaaggcgc aaaactataa 207541 ccttcaggat gctgtgtttc ggaatgtcac atttcatggg gaagtggaag ctgagaatga 207601 aaaggtgtat cagcggggac aggttaacca gcagctgcaa gtactgttga atcgaaacca 207661 tattcatatt ccagagggga cagagctgac gtttacaatc acaccgattg actatcaggt 207721 gcgggtaagc gggacagacg atcaggatct gatcaagcaa attgagcaag tgctgcaatc 207781 tggagacaac agcaaagaac tatttttaca catcatgaaa agtcaaagca gtgattcagc 207841 acaattttcc gaagaggcct ataaaaagta tcaggcagct cgtgagatgt atgaagttac 207901 aggctaccat ttgaaggatt tagaagtgat tgatgggcgg tacgtcacgc ctgagggacg 207961 tgacttaatg gatgtatata aggaagagct tgaaaaagat ccagtgcaga aacaaacggc 208021 ttcttatgct atatcttact atcgttcaga gctcagtaaa atcgcggaag ccgggtataa 208081 tgccattccg gatttcatcc tatcaattga ttacagcaat ggatctctga gagatgtggg 208141 acaaagcaag agctatggga ccggagatac cgggtggctt gaagcattaa agcgtcaaac 208201 gggtgtgaat tattaggtaa gctgttcatg taggacagct tattttttat gagaatctaa 208261 ggggtgaatt aatcccaata ttcaaataat tttattattt ttatataaaa gattttaaaa 208321 gaagtgaacg attcaaaact ctgaacaaag gtgtttacct gaaaaaaaca attgtatttt 208381 ccagagaaat ttattatgat gaaataagta atttaggaga ttatataaca attttaagtt 208441 tgaattttct gattgttatc actgattcat gtgaaggcaa gcaggtctgc tgttttctca 208501 tttatgagta ttttgttagg aggaggaaga ggagtggcaa ataaagaatt aaagaggggc 208561 ctgggcgcgc gccatattca gatgatcgcc ttgggcggta caatcggtgt tggcttgttt 208621 atgggttctg ccagcacgat ttcatggact ggcccatctg tccttctggc ttatgcaata 208681 tgcggaattt ttatcttttt tattatgcgt gcgatgggtg aaatgctgta tgtcgagccg 208741 agcacaggtt cttttgcgac gttcggccat caatatattc atccgatggc aggttatata 208801 acagcatgga gcaactggtt ccagtggatt atcgtcggca tgtcagaaat tatcgctgtc 208861 ggttcttata cgaagtattg gttcccggat ttgcctgctt ggatacctgg tatcgtggca 208921 atggtgattc ttggtgcggc gaatttaatt tctgttaagt cgtttgggga atttgagttt 208981 tggtttgcga tgattaaaat cgtgacgatt atcttgatga ttattgcggg aatcggaatt 209041 attttcttcg gttttggcaa tggcggagat gcgatcggtt tgtcgaacct gtggtctcac 209101 gggggcttct ttgcaggagg tttctcaggt ttcttctttg cactgtctct tgtcattgca 209161 gcctatcaag gagttgagct gatcgggatt acagcgggtg aagcgaagga cccgcaaaac 209221 acgctaagaa atgcgattca aagtattatc tggcgtattt tgattttcta cattggcgct 209281 atttttgtga tcgtgacggt gtatccttgg gatgagctca actcactcgg aagtccgttt 209341 gtgtctacgt tctcgaaaat tggaattacg gcagcggccg gcattattaa ctttgtcgtg 209401 attactgcgg caatgtccgg ctgtaacagc ggtattttca gcgcgggccg catgctgtat 209461 acactgggtg tcaatggaca agcaccgaaa ttctttaaga agatttcacg caatggtgtg 209521 ccgctgtatg gcacaattgc ggtgctgatc ggtttggctg tcggcgttgt actgaactat 209581 atcgcgccgc cgaagatctt tgtctatgta tacagcgcaa gcgtgctccc agggatgatt 209641 ccttggttta tcattttgat cagccatatc ggattcagaa aagcgaaggg tgctgcatta 209701 gataaacatc cattcaaaat gccgtttgct ccttttacaa actatttgac gattgctttc 209761 ttgctgatgg ttctggttgg catgtggttt aacgatgata ctcgtatctc cctgattgta 209821 ggcgtgattt tcttagcgct tgtggtcatt agttattatg tgtttgggat tggcaaacgc 209881 acgcaggcca atttgacaaa aagcgaacaa gcagctgaat aacgataaaa aagagacatt 209941 cacggatgtc tcttttttta tttttcgcgt atggattttc cctattttag caagctatag 210001 ggtaaagata gcagaaggaa aggtgttcat aaaatggatg ttacactcgg ttatttgcgc 210061 gaatcacttt cgaatcatct agaaaatgaa gtctgccagc gtatttgcaa gaagatgctg 210121 gcgaagcgtt atgcaaatga agaggaattt gtaaaagact tagatgataa tgaaatgtct 210181 tttttgaacc atgtattaga aaaagaaatt aagtatgccc agaatgaaca ggatcaaaaa 210241 cgggccaagg aattaaacga ggtgtatgaa ttactgcttt gagaaaggcg ggtaagaaat 210301 gggagcaatt gaacgaagcg gatatacatt tcagccggag tttagcgttg tccgtcaaaa 210361 cggagccatc catgtgtacc atcaaggaga atttgtggaa gaaatcgaat ttgaatttaa 210421 cggggaatat cccgatcatg atttgattga agagcttgtg aatcattatt gttttgagca 210481 tgagatttag agccctgccg tgcagggctc ttttatttag gatgtaatca ggccatactt 210541 tttcaggata tccacggtga tgtttttggc ttttgtgccg gaatcatcga cattggtgac 210601 aaagacataa gagccatgct ctgttttgat gaatccgaca aaccatccta atcccatatc 210661 agtcaggcgg gttccggttt tcccgtagag cgtgtaatga tcgccttcct cttgaatcat 210721 catgcgcttg acgattttca tcaccggctt gtcaaatgga agctcctctt tagccagttt 210781 ctccaaaaaa gtttcttgtt ccagcggaga tattgtgagc gagctttgca gccaaaactg 210841 gtcgattccc ccgctgatat cctcgttgcc gtaagataga gtatgaagcc atgttttcat 210901 tctttcctcg ccgatatctc tcgctaatgc ctgataatac cagattgcgg attcgcgcat 210961 ggccgagcca agcgtatggt cgcggttcca tgattcgaat tcacgcttga ccccgtccca 211021 tcgtttaaca tcgtattcat ctcttacagc tttgacctgc aaaccgatta aagcgttcac 211081 gactttaaag gtggattgcg gagtttgtct ttgatttgcc cgttttctgt tatagacaaa 211141 tgtctgatcc ttttgtaaat cgtgaagaat gaaggttcca tccgtatcct tgaattcatc 211201 atcgacattc attttgctga cattcaagtg tttttcatga gcagatgatg ctgcgtggac 211261 ggagaagccg ccgatccctg caatactcag cacaagcaca acatatatcc attttttcat 211321 tttgttctcc ccttcgtttt gattaactac cttttctctc tttcgtttgt tcttccttta 211381 aaaaataatc aaaaagcgct taaatttggt tttgcaaaca aatactgtta ctgggtttat 211441 agtcggaaga taacgtgaaa atagagggta aaaaggaagg cagggtaagc ggatgaatga 211501 gcagattcca catgacaaaa gtctcgataa cagtctgaca ctgctgaagg aagggtattt 211561 atttattaaa aacagaacag agcgctacaa ttcagatctg tttcaggccc gtttgttggg 211621 aaaaaacttt atttgcatga ctggcgctga ggcggcgaag gtgttttatg atacggatcg 211681 attccagcgg cagaacgctt tgcctaagcg ggtgcagaaa tcgctgtttg gtgttaatgc 211741 gattcaggga atggatggca gcgcgcatat ccatcggaag atgctttttc tgtcattgat 211801 gacaccgccg catcaaaaac gtttggctga gttgatgaca gaggagtgga aagcagcagt 211861 cacaagatgg gagaaggcag atgaggttgt gttatttgaa gaagcaaaag aaatcctgtg 211921 ccgggtagcg tgctattggg caggtgttcc gttgaaggaa acggaagtca aagagagagc 211981 ggatgacttc attgacatgg tcgacgcgtt cggtgctgtg ggaccgcggc attggaaagg 212041 aagaagagca aggccgcgtg cggaagagtg gattgaagtc atgattgaag atgctcgtgc 212101 cggcttgctg aaaacgactt ccggaacagc gctgcatgaa atggcttttc acacacaaga 212161 agatggaagc cagctggatt cccgcatggc agccattgag ctgattaatg tactgcggcc 212221 tattgtcgcc atttcttact ttctggtgtt ttcagctttg gcgcttcatg agcatccgaa 212281 gtataaggaa tggctgcggt ctggaaacag ccgggaaaga gaaatgtttg tgcaggaggt 212341 ccgcagatat tatccgttcg gcccgttttt aggggcgctt gtcaaaaaag attttgtatg 212401 gaataactgt gagtttaaga agggcacatc ggtgctgctt gatttatatg gaacgaacca 212461 cgaccctcgt ctatgggatc atcccgatga attccggccg gaacgatttg cggagcggga 212521 agaaaatctg tttgatatga ttcctcaagg cggggggcac gccgagaaag gccaccgctg 212581 tccaggggaa ggcattacaa ttgaagtcat gaaagcgagc ctggatttcc tcgtccatca 212641 gattgaatac gatgttccgg aacaatcact gcattacagt ctcgccagaa tgccatcatt 212701 gcctgaaagc ggcttcgtaa tgagcggaat cagacgaaaa agttaaatta aaaagctctc 212761 ttcctttatc gaagagagct ttttgattac ttcttttttt catcgtagta ttggacggga 212821 tacatggagc cttctgatac cattttgttg tcctcgatat cttgcgggtc cgggtggccg 212881 gctttatcaa ctgggaacgt ttccatgtct ggctgttttg ttattttcat cttcatgctg 212941 tgaatgaatt ctcttgcctt ttggcgattt gacgggtctt ttaatagata agaagtgatg 213001 ccgacagttg aaacagcgag acctgaaagt aacagctttt gtttcatggt gatactcctt 213061 tctattttaa gaatagtgtt tcctgtatca ttcccgtttt ggaaattgct aaacctgttg 213121 tgtttttatc attggaatta acagtaaatt ccatttaaga agaaactagt gacttcattc 213181 ctgtattgga aggtaatata cattgactta ttatagattt cagtcaaaat tcgataaata 213241 ttgacaaagt aaagtaatca gaataataat ataattagca agagaatgtc atcatacatg 213301 aaaggtgttt acgatatgaa tcaattgcat cgaagaatgg gaacgttttc cctcatgatg 213361 gtcgggctcg ggtcgatgat cggttcaggc tggctgttcg gggcttggcg tgcggctcaa 213421 atagcaggac cagctgctat tatttcatgg gttattggaa tggtcgtcat tttatttatt 213481 gctctttctt atagtgaact aggttctatg ttccctgaag cggggggaat ggtcaaatac 213541 acgcaatatt cacacggttc gtttatcggt tttattgcgg gctgggccaa ctggattgcg 213601 attgtgtccg tcattccggt tgaagcggtg gcctccgttc aatatatgag ttcttggcct 213661 tgggaatggg cgaaatggac aagcggtttg gtgaagaatg gaacgctgac tggggaagga 213721 ctagcgtttg cctctgtatt gcttctcatt tattttctgc tgaactactg gacagtcaat 213781 ctattttcga aagcgaattc attaattacg atttttaaaa ttattattcc gggtcttacg 213841 attggagctt tgctgtttgt cggattccac ggagaaaact ttactggcgg tcaaagcatt 213901 gcgccgaatg gctgggcaag tgtgctgacg gcggttgcca cttccggtat cgtttttgcg 213961 tttaatggtt tccaaagccc gattaatatg gcgggtgaag caaaaaatcc ggggaaatca 214021 atcccgattg cggttgttgg ctctcttttt gttgcgacag tgatttatgt cctgctgcag 214081 atcgccttca ttggagctgt gaatccttct gatattgctc acggctggag ccatctgaat 214141 tttaattctc cttttgctga tctggcgatt gcgctgaata ttaactggct tgttattgtg 214201 ttatatgcag atgcatttgt atcaccgtct ggaacgggga ttacgtatac ggcgacaacg 214261 tcccgaatga tttacggaat ggaaaaaaac aaatacatgc cgagtatatt cgggaagctt 214321 catccgattt acggcgttcc gcgacaagca atgttcttta acttgattgt ttcgttcatc 214381 tttttgttcc tgttcagagg atggggcgta ttagcggaaa ttatttctgt tgctacgtta 214441 atttcttata tcaccggccc gatcacagtg atgacattga gacggacggg gaaagacctg 214501 tacaggcctc ttcgtttaaa aggcttaaat gtgattgctc cgcttggatt tatctttgcg 214561 tcactggtgc tgtattgggc gcgctggccg ttaacaggac aggttctgtt tattatcctg 214621 atcggtcttc cgatttattt ctattatcag gcgaaggcga aatggaaagg gtttggccgg 214681 aactttaaag ccggcgtctg gatggtgttt tatctgctgg ccatgatggt tatttcttat 214741 ttgggcagtg ataaattcgg cggcctgaat gtcattcatt atggctggga tatggttctg 214801 attgcgatgg tatcccttgt attctatgtg tgggcgctga agagcggcta ccagacagaa 214861 tacttaaagg atgcgaaaga gataaattct cagctgctta atggacagtc agaagctgct 214921 gccggaaaag aataaaatat agaagaaaac cttgcgatag ttgtcgcaag gttttttgct 214981 tttaataacc cttttttact ttgtggaaaa gatcaggata gttggtgaac actcctgtta 215041 cgccccaatc aagcaggcga tgcatatcag cttcattatt gactgtgtaa ggatgaagca 215101 ggaggccgtg gctgcggatc atacggacgt tttcttgatt taaagcttta taatccgggc 215161 ccgcaccgac agcgtatgtt ttgatttctt ccagggcagc atctgtcatt gacgccattt 215221 gtttggcttc cagcaattga acggtcggca ggtttggctg taattgatgg acttttacca 215281 ggctttcttt gctgaacgat tgaatgatca cctggcctgg cttagaatgc tttcccagta 215341 atttatgttt ctgcaaagaa gcgatcagtt tttcttccat acctgggtag gtgtcaggcg 215401 attttgtttc aatgtagtag ttcgcgtgct ttccgaaacg gtctaatacc tcttctaatg 215461 taggaacttt aaggccgacg tactgcggct ttgctttttc cggataggct tcattaaacc 215521 aagaaccggc gtcaagcttc ttaatgtctg cgagcgtatg gtctttcacc caacccattc 215581 cgtttgtggt gcggtccagt ttttcgtcat gcatgacaat caattttccg tcttttgtca 215641 tttgcagatc caattcaata aaatcagctt tcattttctg agcggtttcg taagacagaa 215701 tcgtgtgctc aggcacatat ccagaagccc ctctgtgcgc gacggtcagg atacggtcag 215761 gtgacagcag gtttcctttt gacgctgccg acactggcgt taccataaat gagagtaagc 215821 ccagcgacag aacaaacaag gccagtattc tattttttct catgatttct cctccttata 215881 gataagcact acctgtcttt cataataaaa aacggatgta aacggcgtgt tggaaaacta 215941 ttaatctttt atgtgtcttt cttaaacatg ctctgcccgt tttcctgtat tccacgtcaa 216001 agccaagaag acgatggcaa gaatgcagga tgagatcagc atgataaagc cgccgttcca 216061 gttaaaacgg tccacgacaa agcccataat ggcgtttgcg aaggcggatc cgccgatgta 216121 tccgaaaaat ccggtcaaac cggctgcagt tccggctgct tttttcggtg ctaggtcaat 216181 tgcttgaagg ccgatcagca taacaggtcc gtagattaag aagccaatgc tgatcagggc 216241 gatattgtcc acgagcggat tgccggccgg attcagccag tacaccaata cggcaatgaa 216301 aacacccgcc ataaacaaaa cgcctgccgg tgcccggcgg cttttgaaga atcggtcact 216361 gatccagccg cacaagatcg ttcccggtat gcctgcgtat tcgtaaagaa aatacgacca 216421 gcgtgagtct tcaggagaaa agcctttggc ttctgttaag taagtaggcg cccagtcaac 216481 cacgccgtat cgcacgaaat aaacaaatac attggcaaaa gcgatgtacc aaagaaattt 216541 gttgttcagc acatattgaa aaagaatttc ttttgttgtt aattcttttt cctgattttt 216601 aaaagcgtgt tttggatagt cattccgata ctcttcaatt ggcgggagtc cgcaggattg 216661 aggcgtatca cgaaccaata aaacaattaa aaatgaaatg ataatggcga tgatggcagg 216721 gaagaaaaac acgcttttcc aagtgacgaa catcgcgatc ccaagagtga caagcggagc 216781 aagaataccg ccgcctatgt tatgggcgac attccagatc gacatttttg tgccgcgttc 216841 acttatggag aaccaatggg ccatcgtcct gccgcatggc ggccagccca ttccttgaaa 216901 ccatccgttg ataaacataa aaataaacat gatggtgacg ctcgaagtca cccaaggcat 216961 tgaaacgaat agaatattaa cgattgctga taaaaatagg cctgtcgcca gaaaatatct 217021 cggattacag cggtcagaca ccattcccat gatgaatttg ctgaagccgt acgcaatgga 217081 cacagcggcc agcaccaaac ccagttctgt tttcgaaaat ccctgttcct gcagataagg 217141 aatggcaaag gcaaagtttt tccgcagcag gtagtagcct gcgtagccaa tgaaaatacc 217201 aatgaatact tgcagtctga gccgtttgta tgccgcatcc atctttgaat catccagtct 217261 ctcaatatga ggagccggtt taaatatatt aagcattaat aattatcccc ctttgctgtt 217321 tgtgctggat gtgtggcgtg cctcctttcc cgaaaaacaa aaagagccag aaaacacccc 217381 ttgtcaaaag gggttggatt cctggctctc ctcatctcca tccaagctat taacttatca 217441 tgatagcgct ttcttaaatt atcatagtcc ggagcgaatg taaacgggta attttcaaat 217501 tgggccttag ggaagtgaat attatccttt tactaaatgc aattatattt ttttactagt 217561 aacataaaaa tctggaggga ggctgtttaa agatggatga attagatatc gcattcttta 217621 ttttaccgtt aggaattatg ctgctatcga ttgtcgggac ctgtatttgt aaaaacccgt 217681 atctgatgcc aatgcttagt ttggtgattt ctcttgtgct cacctttacc atttttaatc 217741 aatcattttt gggatgggct gttgtctata gcttggtttc tctggcttta tcctatatca 217801 cattgattgt ggtaaggaaa aggaaggaat caggaaatta aaaagacctc actttctaac 217861 atatcgttga ctaaagcaac tatatgtgat tataattgct ttagtcaacg atattagaaa 217921 gtgggaattg atttgaaaac aagagaatca tctgtcgggt taaaattcag aaagttcaat 217981 cgattttata caaacgtcct tggtttcctt aatgagcaca tttacgacag cccgttttcc 218041 ttaacagaaa cacggatttt atttgagatt tataatacgc ctaattgtac ggcaaaagct 218101 cttcaggata agctggggct tgaccgggga tatgtcagca ggattgtgaa gcagtttgaa 218161 aaagaagatt tgatttataa acagaggagc aaagatgacg cccgccacca ttacattttt 218221 gtcacagaaa caggaaaaac gatttataaa aagctggagg agaaagccaa cgaacaagta 218281 gaactgatgc tgaaggtaat caaccaaaag gagcagcaca agcttgccga ggcgatggca 218341 gagattgaag cgatcctttc acagtcgctt tctgccagag catcagagat atcgattaga 218401 gattattttc tttcggagga tcttcaactc cttattgaga aacaaagaca attttacgcg 218461 gaggctcacg gttgggatga cacgttttta gcttatcttc aggagacatt tgacgctgac 218521 atcgaaaaaa tatggattgc ggaaagcggc gggaaatttg ccggctctgt cgggttggtc 218581 aagcacgatg aaaagacagt ccagctcaga tggtttctgg ttgatgcgga ttttcggggc 218641 agggggcttg gcacgcaatt gctggagcat ctggttgcat actgccaaga catgaagttt 218701 gaccgcattt tcctttggac ggtgagcacg atggctgagg ctcgtccgct ctataaaaaa 218761 tttggattca ggataagtga agtaaaacaa gaagcgccat tatggggaca gcagctgaca 218821 gaagaacggt gggatttgga gctgtcatga aaagactgca ttatgcgtgg atcatcgtct 218881 ccgtcacctt tttgatctta ttggcggttc agggggtgcg gctgtcgttt ggtgcgtttg 218941 tggagccgtg ggaacggcag ttttcaatcg atagaagcac catctcgctg atttcgacgg 219001 tgagttttat tgtttatggc atatcacagc ctgtgatcgg tcggcttgtg gacaaatggg 219061 gtgcccgggc tgttttggca tggagtgcgt tactgacagg agtcagcatt ttcttaacat 219121 accttgtgac ttcgccttgg cagctgtttt tgctttacgg gctgggtgtc tcgcttggag 219181 tgggcggagc atcgaatgtg gcggcaagtg tattggtcgt caattggttc agcaaaaagc 219241 ggggactagc ctttgggatc atggaagcag gctttggcgc ggggcaaatg cttctcgttc 219301 ccggctcact catgttgatc cattggttta gctggaagct gacggttgtg gtgttgggac 219361 tgctgttaat cgtgattgtc tttccggctg cgctgctgat gctgcggaac aatccttcag 219421 aaaagaatac agagccgata ggcggactgg ctgcatcaga aaaagaaaca gcacccaaaa 219481 caacagctct ttcagtggcc gggatgtttc gtatgaggca attctggttc ttgatttttc 219541 cgtttttgat ctgtggattt acgaccgtgg ggctgatgga tacccatttg attccgtttt 219601 ctcatgatca tggcttttca acgacagtca cgagtgctgc tgtcagtctg ctagcaggct 219661 ttaatattgc tgggatcttg ctgtccggaa ttgtagcgga ccggtggagc agccggaaaa 219721 tcctgtgcat tttatatgcg gtgcgggcgc tgtcgatcgt gattcttatt tacagccacg 219781 agccctactt gcttttagcc tttgcgattc tgtttggatt agtggacttt gcaacggtag 219841 caccgactca aatgctcgcc acccagtact ttcaaaacta ctcgatcggc ctcatgattg 219901 gctggctgtc actcgcccat cagatcggat cggcactagg tgcgtatgtg cccggcgtca 219961 tctacacggt aacgggtgag tatacactgg ctttttattt gtcgattgga atgctcgtgc 220021 ttgcgagcgt aatgaatgtg atgctgaggg agccagctgc ggttacgcgt gacagtgcgg 220081 ctgtggtaga caagtgatga ggacaaaggg aaagcatctc tgatttcgag attattcaga 220141 gatgcttttt ttgtattttt gttctaatac gaagtcgatc ataccgacta tgcgggcgtt 220201 ttcggatttt tgtttgaagc gttcagaaat ttgaactttt cttgaaaatg gggaaacaat 220261 aaaaacccaa aaaaggccga tcaaggcaaa aaacatttgt acagctaatt ctattaattc 220321 attaaaacga gtgctgaaaa aatagaagta taacgttatt aatgtcacag tacatacgat 220381 tttggcaagt gtgtttgaat gtaagcaatg gttcactaaa gaataccttt aattgattca 220441 gcatgattga atcatatttg tttaggaaaa taagaagttc tttatcatct tttttatgtt 220501 ctaaaataaa gttgctgttt ctgtttcttt atatgtatgg tggtctacat tcaatatata 220561 catctcttaa agtataaaaa ttgagtattt cttagtaagg atgaaacaaa attacatgat 220621 ttttttgtta tatctttcag ttagaataaa atctataact cctctcattc gcaaatattc 220681 ggctctctgt gcaaagtgca gaacagtatg taattgtcct tttctagata tatttaaaag 220741 ctttatcaaa tcaataagga ttttcaagaa aataattaat aatagaaaga taaaaatgtg 220801 tggtatgtca atgtaattga tttgtcctga aaataaagaa gttgcataga caacaataat 220861 acttccgcaa aacatcaaac tcatataatg tggaagggaa aatggacgag ttgaaaaata 220921 tgcttttaat tggcttagca tagcattatc tcttgtatct aagtagccca aaagctcttt 220981 atcattttta ctaattgtaa gaacatgatt caatacagca ctaaaattca ttgaatcttc 221041 attatcagag gcagtatgtt tattagcctg tatgttttgt tgatccattt tatatttttt 221101 ataaagtatt gtattaatta acttgttttt ctcatagaat tcagatcgtt gattaaggga 221161 tgcttttcct ttgtttttat ttcctttttt tatgatttta gtataagtca taaaaataca 221221 aatgactgta aaaatagaaa acactgcagg tgaaatatct gaaagaatag tattggtgaa 221281 gacttctttt gcttggatga aaaggaaaga agctaaagtc atagatataa acatgcataa 221341 aactgctact ttcacaagaa actgaagcgg aagagaaggt tccgaataat agtgcttcaa 221401 ctggttgagt gtcagagaat cttggcgaaa aagataatct attatctcct gctgattttg 221461 catctgattg atatcatgag cgatgttttt tgttttttca aaaactattt gatcattttt 221521 catttttgat aaacctccaa aagacgatag ataaactaaa aaaactgcat gagcatattt 221581 taacttatgt tcatgcagtt ttgtattaaa gttagctagt ataataagca aaaatggcca 221641 gtaacatagc agataatgcg gtagcgactt tgactccttt attgttcgtt aaatcactgc 221701 ccatattccc aattagtaaa agtgcagcaa cacctacaac agggaataaa tattgatcat 221761 aagacggcca atctaacgct aattcactct cgggagacgt aactggtact cccttgtacg 221821 tctttatttt aaacgtaatc gtagtcgtta gtccagttgt gacattgtca ccgactggaa 221881 tatcaggtgt atagatttta atttgaatgt ttaaagattc agctgttgga tttacataaa 221941 cctccaaata accgttgcgt actgataagc tcagactatt taaaaggttt tgataagagt 222001 cgatttgtga cgcagtgaga gacgtttgag tgtcgcccaa taaacccgtg atataggcac 222061 ctggtttacc atttgtaatg gtaattgtgt ttggtgaacc ttcacttggt atggttgcca 222121 gaagtgaagt tgatagaata atatccaact caggtgatgt gaaaatggtt tctgtcgtat 222181 caaattcaaa catcgcgttt gccagacttg ttagattttc taaagctgga atggtagata 222241 aaatgtctgt cagtgtacgc agtcttgcat catataccgg atcagacggc ggatttacat 222301 tgcttgcacc tgagtctctt cctgaatacc cgtctttatc aatcccgatg cttccagagc 222361 cgcttccgat ggttccttca taaaattgat caaaggccca gttgtttggc atcggatagc 222421 cgagattgcc gctaaatcct gttgacatat ttgccacaaa actatacttt gtcagtcctg 222481 cttcagatgt acggatacaa atgtttcttg gtccgtaaac ccctatttca tacttaggtg 222541 cggttgaaaa tgtctgcatt tttgtaaatg ctgacttaat ctcttggaaa taaggaatga 222601 ttttatcggt cacttcataa tcgtatgcat caaaatcgac agcgaaataa atggtcgtgc 222661 ctgacggaaa acctaatctt ctagcagcag aagcggcact atatgcatct cttgtgcctt 222721 ggtctttgac aaaataagaa gattcatagc cgccgtcttg ataaattggg aaaaccttca 222781 atccggcatc aagaataact gcaagctctt tagatgtcag ggctttagat gtgaggccgc 222841 tgcttgtccg cacatttccg gtcaaatatc tgccaaccgt tttataaccg ttattccgca 222901 gtgtttgagc tttttctgcg gttataattg tagcagtgtc acaagcagaa gcggtgcgag 222961 ttgtgtctcc tgagcttgat aataaagctt taatggttgg catatctgca taacctgttt 223021 gcggcaggca catgaactct tgaaatgctt taacagctga aacaacaccc acaccatatt 223081 tgccgtcaaa ctcaccagga tcgaacgatt ttccgttaca atagagggcg tactgaacaa 223141 ttaagacaaa tcctgttctt gaatcgccgg gagttaaagt agggcacaaa cttgtggtgc 223201 cgtttccgaa aaatccattg gcaacacttg tgctcatgcc ttcttctttt tgcagggcat 223261 aaataagagc tttatttgta tcgcggccat acagtccgtc acaaggcatt aacccgatat 223321 agtcattgta gtctcgattt aagttttgtt gaatctggcg aattcttgaa tcacccccag 223381 acaccagctt aaaagcgctc atgtctaata aggctttcat aattaacgtg gtgacaatcc 223441 catcctgtgt tgtcagtccg gcagcttttt gaaattcttt taccgcattt tctgtttttt 223501 cgtaaaagac gcctgtaaaa ccgccgggat taaagccttt acaccataaa gccccttgta 223561 aaataaaatt catgttgctt ggttttgaat ctggagcttg gcgtttaaga ggcttaaata 223621 agcgctgtgt tgtcggcccg aagttatcgg ctggctctga gatacccaat tcaatttgaa 223681 gcgcccgagt cagaccgtag atcgtatccc acccagtttt cccgctttct tcaactgggt 223741 tatacccatg tttgccgctg tacgtatcgt tcagccattg ctgtgtgatt aagaccattt 223801 catcaaccat ttcgattcct cctttgttag attgcgttca tttataggtg gcaaacgtag 223861 gacaaaataa aaaaatggat gccgttaagc atccatttta catccgttct ccaacagctt 223921 cgctttcggt ttcagctctg aaatgtagag gcctaaaagt gtaagcgcgc ctcctagaag 223981 agcgatccat gtcatgtttt cgtgcagaat caggacagaa gcggcgatcg tgataaccgg 224041 gaccatgtaa atatacgcac tggatttgac ggctccgagc actccaactg aataattcca 224101 agtggcgaag cacagggcag aagcgccaat ccctaagaaa agcatgttga gtatatttga 224161 agcagatgaa aatcggctta ggtcaaaatg gaagtcgaac aaaaataaag cgggaaccat 224221 aaacaataaa ccatacaaaa atactctctg tgtcagctcg atgatgtggt attcgtaggc 224281 gcttaatttt ttcatgaata tcgagtatcc gccaaacacg agagcagccc cggctgccat 224341 gatgtctccg agcggattta gacgcagtac cacattgccg ttaaacgtaa tcaataaaag 224401 cccgatcagt gccgagataa atccaatcaa aaaagtcaga cgcaattttt cgccttcgag 224461 cagaaaatgg gccaaaaccg cagtgatcat cggtataatg gacacgatca tgccgacatt 224521 ggaggcgtat gtataggtga gagctatatt ttctaataga aagtataagg ttacgccaaa 224581 taaaccagct ccggcaaaca acagctcctg ccgccaattt ctgaacggaa tcatgttggg 224641 acggacgagg ataagagcga taaagcccat caaaaaccga taaaataata tttccattgg 224701 agagaagtca gccagcagaa cttttgtcga aataaaggtc gtcccccaaa tcagaatggt 224761 cacaatggct gcgatatgcc ccgaagtttc tctttgtatg ttcatctgtg aagctccttt 224821 tcaaaaatct tcatgtattg cttcggcgtc agccccacct gccgtttaaa aaacttcgtc 224881 atatgactct gatcgctgaa tcctgtctga aatgccgcat caatcggcct taccccttgt 224941 tcaaggagtt ttttggcttg attaatccgg attgtttcca tgtagctatt aggggtaatg 225001 cctttttgtt ttgtaaatga acgcaataaa tgatacttgc tccagcctgt taattcactc 225061 aaatcattga gtgtaacatt ttcggcataa tgctcttcta aaaattcaca aaccattttg 225121 acttcgtctg atggttctgg aacgctgcta aggaacgtga catctgaata atggcggatc 225181 agctcctcta atagatgaag aaacagctcc tccttacgca aagcttgttt ttcctcggat 225241 atcaaaatat gcaattcctg caggctggct gtcagctcat ggcggaataa cacatgctgg 225301 gagaaataag ggagatgccc ggagccagta atctctttca ccgccttctc catgatatcc 225361 ggcatgacat tgatacaccg ataatcaagc gtccggccgt caatctgttc acagctatgc 225421 gtgtcacggg ggttaaagag gagaagatca cctggattga tgatatattc ttgatcctga 225481 caggccagat accgttgccc tttttcaata aatccaatca cataataatc gtgaaagtgg 225541 ttcgggaact tctgcataat tcccttgaag cggtaggctt ctatatgaag gtgtgggtca 225601 agctgcagtg tgcgggtttc gttttgcatg ggatgcctcc tgtcggtgtg gtggtcttgg 225661 attaagtgta gcatgatttt gggggatttc ttgtatgatg ttgctgttta ggaatagaga 225721 aagcagaccg ttatttgtct gctttcgttt aagaatttaa aagattttaa ccctcaataa 225781 taattttatc ttttttaata aaaatttatt tttcaaatat ttcagttata atggtttgga 225841 acagatagga ggggcaaaga tgtatcaatc aaagaaggtt ttattgttag gttcaggtga 225901 attaggtaaa gaggtagtga ttgaagccca gcgtcttggg gtacagacgg tggcagttga 225961 cagttacgag catgctccgg cgatgcaggt cgcgcataac agttatgtcg ttgatatgct 226021 ggacccagag cagatcagaa ccatcattga gaaagaaaat ccggatttga ttgtgcctga 226081 ggttgaggcg attgcgacgg atgaattgct gaagcttgaa gaggaaggat ttcacgttat 226141 cccgaatgcc cgtgcggcca agctgacgat ggatcgggaa ggcatcagac gacttgcggc 226201 ggaaacgctt ggacttgcga cagctggcta tgaatttgcg aatacatatg atgaatttat 226261 acaagcggca gctcagatcg gttttccttg tgtcgttaaa ccattgatga gttcttctgg 226321 aaaaggccaa agtgtgtgcc gctctgaagc ggatttagag agctgctggg agacggcgat 226381 ggaaggcgga cgggtgaaaa acggccgcgt gatcgttgag gagtttatcc ctttcgaatc 226441 agaaatcaca ctcttaaccg tacgtgcggt taacggtacg gcattttgtg agccgatcgg 226501 tcatgtgcaa aaggacgggg attatatcga atcgtggcag ccgcatgata tgacagagca 226561 gcaaatagaa gaagcgaagc atattgcgaa aacgatcacg gatgagcttg gcggatacgg 226621 cctgtttggt gttgagctgt tccttgcgaa agatagggta tatttcagtg aggtatctcc 226681 tcgtccgcat gatacgggtc ttgtcacgct ggtgacgcaa aatttgtcag aatttgcgct 226741 gcatgtccgg gcgattctcg gctttccgat tacagaaatc acacagcttt ctcctggcgc 226801 cagcaggccc ctcaaagcgc cggaagaatt agcggattac actgttgaag gattggaaaa 226861 cgcactggca gtcccaaaga ctcaagtgcg cgtctttgga aagccgataa caaaagccgg 226921 acgtcgtatg gcagttgcgc tttctgctgc tgattcagtt gaaacggcaa gagagaatgc 226981 aaagaaagcg ttggaccagc taattttaaa atagagtttg aacaggtctt gtcatgggac 227041 aaggcctgtt tttttctttc tccgtaaaag ttttatcata agaatcagaa acctgattat 227101 aatgtaaaag tcttccatcg atacgggtgg ttgacactaa aggagggaga tgacaaaatg 227161 aaattagttc caagattcag aaaacaatgg ttcgcttact taacggtttt gtgtttggct 227221 ttggcagcag cggtttcttt tggcgtaccg gcaaaagcgg cagagaaccc gcaaacttct 227281 gtatcgaata ccggtaaaga agctgatgct acgaaaaacc aaacgtcaaa agcagatcag 227341 gtttccgccc cttatgaggg aaccggaaaa acaagtaaat cgttatacgg cggccaaacg 227401 gaactggaaa aaaacattca aaccttacag ccttcgagca ttatcggaac tgatgaacgc 227461 accagaatct ccagcacgac atcttttcca tatagagcaa ccgttcaact gtcaatcaag 227521 tatcccaaca cttcaagcac ttatggatgt accggatttt tagtcaatcc aaatacagtc 227581 gtcacggctg gacattgtgt gtacagccag gatcatggat gggcttcgac gataaccgcc 227641 gcgccgggcc gcaatggttc gtcatatccg tacggtactt attcaggcac gatgttttac 227701 tccgtcaaag gatggacgga aagcaaagac accaactatg attacggagc tattaaatta 227761 aacggttctc ctggaaacac ggttggctgg tacggctacc ggactacaaa cagcagcagt 227821 cccgtgggcc tttcctcgtc agtgacagga ttcccatgtg acaaaacctt tggcacgatg 227881 tggtctgata caaagccgat tcgctccgct gaaacgtata agctgaccta tacaaccgat 227941 acgtacggct gccaaagcgg ctcgcctgtt tatcgaaact acagtgatac agggcagaca 228001 gctattgcca ttcacacgaa cggaggatcg tcatataact tgggaacaag ggtgacgaac 228061 gatgtattca acaatattca atattgggca aatcaataaa tacagcaaac tagccatatt 228121 catgtctatt ttgtttttat gcgggtgcag ttcgcagacg cattcttctc aaaaagaaac 228181 gactattcct gtcactcttc atgtggagga tgctaagggg ctgccggtcg aaggggttca 228241 agtgacgatt gtcaaagcgc cctcttcaga tgaggagccg agtacagaga ttggcgagat 228301 actcggtaaa acagacaaaa acggagatat caaatgggat accggcagaa aaggcgatta 228361 ctcagtcgcg ttgacgaagg gtgaaacatc agtaacccat cacatctcgt taacagagga 228421 taaaaaagat catgccattc cattagtctt caaagaatag cagtttcctt gattttaagg 228481 gaactgcctt ttttatttat tgcaggaaac caaactatat actggaaatt tattatgtga 228541 gataataaga aataggtatt ttttcttacg agacaaaagg ggcgttatcc tttatatcaa 228601 tcaaacccgg aggaaaaaga agaagatgat acaagattca atgcagtttg ccgcggttga 228661 aagtggtctg cgcttttacc aggcatatga tcaaagcctt tctttgtggc cgattgagtc 228721 ggaagcattc tatgtttcta ctcgttttgg aaaaacacat atcattgcaa gtgggccaaa 228781 ggacgcacct tcgctcattt tgcttcacgg aggccttttc agctctgcga tgtggtatcc 228841 gaatatcgca gcgtggagca gtcaatttcg tacatatgcg gtcgatataa taggagacaa 228901 aaataaaagt ataccatcag cagccatgga aacgagagct gattttgcag aatggatgaa 228961 agatgtcttt gattctcttg gacttgagac ggcacatctg gccggccttt cgcttggcgg 229021 gtcccatatc gtgaatttct tactccgcgc gcctgaaaga gtagagcggg cggttgttat 229081 cagtcccgct gaagcgttta tttcatttca tccggatgtc tataaatacg ctgcagagct 229141 tacaggggca agaggagctg aatcatatat caagtggatc acaggcgaca gttatgatct 229201 gcatccttta ctgcaaagac aaattgtggc gggcgtggaa tggcaggatg agcaaaggag 229261 cctgaagccg acagaaaacg gctttccgta cgtgttcaca gaccaggaat tgaaatcaat 229321 acaagtcccg gtacttctga tgttcggtga gcacgaggct atgtaccatc agcaaatggc 229381 ctttgagcgg gcttcggtat tggtgccggg aattcaggct gaaatcgtaa agaacgccgg 229441 acatctgtta tctctggagc agccagagta cgtcaatcaa cgcgtcttgt cctttttatg 229501 cggggggata aaatagtaag gaacatgaaa agattggcat tcatttttca aaaggtaaca 229561 aatgttgtat aataatagaa tttgaatgct gctttttttg ggagcattct atgttatcat 229621 gcttattgga gaaaaatttt tcctgtaacg ctattcgatc actatcgtca aataatatag 229681 atggttttac aattggaggt ttggttacac tgtgaattac atcccctgta tgattacgat 229741 aggaaacttc atttgcggat tgctggcgat tcattccttg ctatatcaca acattcattc 229801 agcagtgctt tttattttta caggcatgtt ccttgatttc tttgacggga tggctgctcg 229861 taagctgaat gccgtttctg atatggggag agaactggat tcgtttgccg atctggttac 229921 gtttggggtg gctccttcta tgcttgctta cagtgtcgcg ttgtataccc tgccatttat 229981 cgggatctta tgcgcattga cgtacagcat ttgcggaatg cttcgcctct ctaaatttaa 230041 cattgaacaa agcaagctcc cgacgtttat cggtatgccg attccgtttg cgggcatgtg 230101 tctcgttatt ctaagcttca cctataaccc gatccttctg gcaatcggca cttgcggact 230161 ctcatatttg atggtgagta aaataaaatt ccctcatttt aaaaaacatg cggcagaaaa 230221 cctggagtct gggagatgga attagttcag cagctcatag cggattacgg ttatctcgct 230281 atttttttga tgctggtatt aggaattgta ggattgccga ttccagatga agtgatgatg 230341 accgttgttg gctatttcac gcataccgat gtattgaatt atgagctttc gatattgatt 230401 agttttgtcg gggctttgtt aggtatgctg atcagctaca tgattggcag aaaagccgga 230461 cgcccgttta tcgacaagta cggcaagtgg gtcggcttaa aagaaaaaag aatgatgaaa 230521 gtggaaaaat ggatgaagaa atacggtcca tattctctta ttttaggtta ttttattccc 230581 ggcgtcagac atgtgacgtg ctacttttcg gggatcggca aaatggatct gaaaacgtat 230641 gttgcgtttg ctgcaatcgg cgccttttta tggtgctttg tttttattac aatcggaagg 230701 gttataggga ttattcatgt ttaatacggc tgtaaagatt ctgtatcgat cattgataga 230761 gctgacgaat catcgtctgt catcctatct gattaaagga ttttgcgagt cgaaaatcag 230821 caaaccggtc attccgcttt tctcaaaaca ttttcggctg aattgggatg atgtggacgg 230881 tacggctgct gattacggat cgctgtccga attgttcatt cgacaaataa atctggagcg 230941 gcgccctgtg tcaaaagagg cgcatgcggt ggtcagccct gttgacggtg tggttcagac 231001 ggtaggaatc atcaacccga atcaaacctt tacggtgaag ggaaaagatt actcattcgc 231061 tgagctgacc ggctgtaaaa gcgcagacca tcaatacaac ggcggatatt tcgtcgtgct 231121 gtatttaagc ccgaggcatt atcaccgttt ccattctccg atcagctgca ggtatcaaaa 231181 gctggccgag ctcggaaatc gctcataccc ggtaaatcaa ctaggcttaa aatacgggaa 231241 agatgtgctg tcgaaaaatt atcggtttgt gtacgagctg aatagcggca gccgaaatgt 231301 cctgatgatt cctgtcggcg cgatgaatat taattctatc gtgcagacga atacccgtac 231361 tgaattggag atcggcgagg agctgggata cttttcattt ggctcaaccg tcattttggt 231421 ttttgaaaaa gacgcgttcc agccgtccgc ccatttagca gaaggccaag aagtccaagt 231481 cggagaactg ataggttacg aagaataaaa agaggagctt gcataaacgc agcgcctctt 231541 tttttgaaga aaggtgagat tcatggagaa acaaatcatc agctggatta cagattatca 231601 gaacaccgga gatgaagccg tcctgcggca agtgcgagaa gtgtgctggc cgatcgttga 231661 agcggttttg caagagaaag taatggatga tgaacaagcg aacaatttgc gcgaaaaagg 231721 aatcgagcgg tttccattca tcatcagcaa ataccaagcg gatgtgcagc ttccggttga 231781 gacattttta caaaatacgt atcggtttta ctttcatcag gtgatgagag aatccagcta 231841 aagcttcttt caacagagaa gctttttttt gttggcagga aaaggaaact ttttctatat 231901 ctatctcgta atgactagag aacctagcag aaaaggagag atagaattga aacgaatgat 231961 agtgagaatg accctgccgc tgctgatcgt ttgtctggcg ttttcttctt tttcagcctc 232021 agcccgtgct gcttctgaag aaaaatattg ggatcactgg attgaacgac atgcacagcc 232081 tctggatgct tccaatgctt caaacaaaga ccttcgattt ctaaaaaagg tgctgaaggg 232141 aaaacgaatc gttcagttag gagaaaccac acacggtgct ggcgaaatca atgccacaaa 232201 ggtcagaatg atcaaatacc tccacgaaga gctgggatac gatgtattgg cctttgaatc 232261 cggctttcct gatacaaatg catcctacct taatatggac caattaaccc ctaaaagcac 232321 gatgaaaaac tccatttacg ctgtatggca cacagaagat gtcgtcgaat tgtttgatta 232381 catgaaagag caaaaagaga aaggcgatcc gctgatcctt accggttttg atattcaaag 232441 catgaagaat tcattcaatg tagctgcgac tcaatgggta aaagcggtgg accctgagaa 232501 agcagagttg ctctcccaat cagaaaatga tttttcaaca ttagtgacag acagcaatac 232561 gtttgatgaa ttttcgcaaa agaaggaaaa gcttgtgaaa aactatcaga agctgatcaa 232621 gttcactaaa acacatgctt cagagctaaa agaaaacctt ccaaaagagc cgaaagctta 232681 tgagatgttt atgcattctc ttcagctgag aattgacgta atggaaacat atatgctgga 232741 agaaatgaaa gaaaaactag aggagtatcc ggagaatatt gaggattttt cattctttat 232801 gagagaccgc atgatggctg aacaatttca gtgggtagcc gacacccttt atccgaaaaa 232861 gaaaatcatt gtctggggcc acaattacca tctacgcaaa cagaatacga agatgataaa 232921 ggactgggta cagctaaacg gccctaacat gggtgattat ttgccggagc ggctgaaaaa 232981 acaaacatat acgattggca tttatgctta ctcaggtgcg agtcttgata gctccgataa 233041 taagactgtt aagccggtta caagcccgcc gccgtctggg agccttgaag ctttgctgaa 233101 agcggcggac cgaccggctg tttttgttga ttttctccat acaaaaaaca agaaaggcac 233161 ttcgtggatg tataccccgc ggactgcgct ctattggggg tacatggaag agcagatgat 233221 cctgaaggaa caatatgacg gtgtcatttg gctggagcat atcacgccct ctgtcattat 233281 caagtgagcg gtgtcccctg tggtaaacag gggattttta catatcgcaa aaataatcaa 233341 aacatataat ccgtgatcca ttattctaaa acagaaagga gattggagcg tgcaatgtat 233401 tatgaaaaag ctgtccagaa aacaatcaat tggattgaat cacatttaca tgagcaaata 233461 tcaaacgagg atattgttaa cgtttcaagc ttttcaaaat tccattttca tcggattttt 233521 caaaaagaag tcggcatgtc ggttgcttct tatattcggt taagacgtct tgcgaatgcg 233581 gcggcagctt tgctttatac agatcatcgt attatcgata ttgctttgta ttatcagttt 233641 gaatctcaag aagcatttac gaggacgttc aaaaagatgt atcacatgcc gccaggagca 233701 taccgaacat ttatgaaacg ctttacttca aaaaaggagg aatcttacat ggagaaaaaa 233761 atgaaaggct gggtattgag cgggagccat ccgttccaat tcgaaatggg gattgaccgg 233821 gaaaatgtac atcagggaaa agcttcaggg tatttaaagt caacgatggt tcaggatatc 233881 ggtgaatttg cgacgatgat gcagcaattc aaagcagatc gctatctagg aaaaaggctt 233941 cgtctatcaa gttttatcaa aacaaagggg gtgcagcatt ttgcctcact ttggatgcgg 234001 gttgacagtg ctgctgatga tgttctccaa tttgataata tgagcaacag acctattacc 234061 ggaacaacca attggaatca ttatgctatc gttttagatg tcccagaaaa tagcgctgtg 234121 atatcttttg gcgttcaatt atctgggccg ggtcaggtgt ggatggatca tgttgttttt 234181 gaagaggtag atgagagcgt tccttcaaca aaccttgaaa tgccgggaga acttttagat 234241 gaaccggtaa atttatcttt tgaagaggaa ctacaaaaat agttttcaga caactacttt 234301 tattagtgag ttaatggaaa atactatttg ttattaataa acccttgtgc tgcttaggtt 234361 tgtaagagct tggatatttt tatcagtctg ggcggatctg ttcatctttg cggcattttc 234421 ctgtatgata tagtaagagt gtgcatagca actaactata attgaacagg gtgtttaaaa 234481 catggaaaaa caatacagag tattacttta ctataaatat gttccgattg aagatccaga 234541 ggcgtttaga gagcagcatc tggctttttg taaggagctt ggtttgttag gccgtatcct 234601 tgtttcttct gaaggaatta acggtacggt atcaggtacg gttgaacaga ctgaaaaata 234661 tatggaaaca atgaaagctg atcctcgctt tgcggacatg gtatttaaaa ttgatgaagc 234721 agaaggccat gccttcaaaa aaatcttcgt ccgccataaa aaagagcttg taacgcttcg 234781 tcttgaagat gatgtcgatc cgaacgaaac aacaggccag catttgaagc ctgcagaatt 234841 ttatgagaag atgcaggatc caaacacaat tgtcatcgac gcgcgtaacg attacgagta 234901 tgaccttggc catttcagag gtgcggtccg tcctgacatc gaagccttcc gtgaattacc 234961 tgaatggatt gaagagcaca aagatatgct tgaaggcaaa aagattttaa cgtactgtac 235021 aggcggcgtg cgctgtgaaa agttctcagg atggctggtg aagcaaggct ttgaagatgt 235081 agctcagctt gatggcggaa tcgtgacata cggaaaagat ccagaggtgc aaggcaagct 235141 ttgggacggc cagtgctacg tatttgatga aagaatcagc gtgcctgtca accgtgtcga 235201 gcatgtgatt gtcggcaagg actactttac aggagaaccg tgtgagcgtt atgtgaactg 235261 cgcaaatcca tcttgcaata aaaaaatgat atgcacaccg gaaaatgagt ataaatatat 235321 gcgcagctgc agccacgaat gccgcacgaa cccaagaaac ctgtatgtga aagagcataa 235381 tatgacagaa gaagaagtaa acgcaagact ggcagcgatt gaaacagaag atcacgctgc 235441 tgctgaataa aaaaagaaca cctcgtattg aggtgttctt tttttctata tgctttcagt 235501 ttggctgttt gcggaaaccc attctttttg gcggaaggcc ttttcccatt ttgataccac 235561 gatacaggcg atcgcatgtc ccggtacgtt cacgcctgtt ctcgccatgt ccatgacgcg 235621 gtcaacaccc gcgataatgg caacgccttc agccggcagt cctacagcat tggcagtcgc 235681 cagaagaact acaagcgatc ctgagggtac agctgcaatg cctttactgg tcatcacaag 235741 cacaagcatc atgagcagct gctgggacaa tgtcatgtct acttgaaagg cctgtgcgag 235801 aaagatacaa gaaaccgata aatataagct ggagccgtca cagttcaatg acaagccgga 235861 gggaacgaca aatgatacca ctcgtttggg acagccgtat ttctccattc tatccatcag 235921 ctgagggaga atggtttcag tgcttgtggt ggaaaatgca attaaaaaca gatcccatat 235981 cattttcaat acttcgaaat acttaatctg aaagatgaga ccgacaagcg gaaagaggac 236041 aaagaggatc aggaacaggc caaggaatac ggtgccaacc agcttaaaca tagggaggag 236101 gagttcaatg ccatattggc ctacagaagc agccatcagg gctaacacgc cgataggagc 236161 agtgaccatg acgatttgcg tgagcttgaa cataatctga gctgtagatt caaaaaactt 236221 cattactggt tcagaagctt tgccgatacc agctgcggcg acaccaaata aaatggcgaa 236281 gaaaataacg gcaagcaaat catttctggc catgacatca ataatgtttg tagggataat 236341 atccaggatc atttgcttga aatcaacaac tttgtctgtg tagccggaaa gttcatgaat 236401 atcttttttt gccaaatggg agaggtcaag cccgacacct ggttttaaga cattcgctaa 236461 taaaagtcca agccctaata ccaacgttgt aatcacttcg aaccaaatga tcgtcttgat 236521 gccgagactg cccatttttt tcatgcttcc gcttcctgcg gctccaatga caatggtaga 236581 aaatacaatc ggcacaacaa tcattttaat caggcggata aatccatctc cgacaggcct 236641 cagtgccatc ccgaaatcag gaaaaaagtg gccgatcacc gcgccgacag ccaaagcgat 236701 taaaatttga aacgcgatta attttttcaa atgaatcccc ctttagaacg atagaatgta 236761 ggcatattca tatcattcgt gattcaaatg caaacacctt ttttcaagtt attttatttt 236821 gacagcgctt tcattatgtt ggcgaaaaag tcccccgcag caggggggac ttttttactt 236881 catttgaatg tgctttagat cttcttcaga ggtatttgtg aaaataaccg gtgttatggc 236941 tgaagcggca tgctgcttga tgtaattgag atcaaaggtg agaagcagtt cgccttgttt 237001 gacggcttgt ccgcttgtga catgtgcttc aaagccttcc ccattcagtt tgacggtatc 237061 gatgccgaca tgaatcagga tttcagtgcc gccggcgctc ataaagccga tggcgtgttt 237121 tgtcggaaaa atcgagacga tctcgccgtc cgcaggtgca acgacttttc cttctgatgg 237181 tataatcgca aatccctcgc ccatcatttt ttctgaaaag acctgatcag gcacatcccc 237241 taaagagact gtttctcctt taatcggata aataaaggtc tcatcggaat cgggcttcag 237301 cggtttgtca gttaccgtgt ccagcgcggc ggcggtggca gggacgcctc cggccatgat 237361 tgttttgatg tcgtctttta aggcatcgga cttggttccg aatattgcct ggaagttgtt 237421 gttgacctcc agcacaccta ctgcaccaag ccgttttaat tcatccttgc agacttggct 237481 tggctgatga acggtcacac gaagccttgt gatacatgca tccaggttag cgatattttg 237541 ctgtccgccc aaggcctgca gcacgtgaaa ggcaagctgg tcttttgcaa ctggagcttt 237601 ctcctcattc tgaccgtctt catctgtctc acggccgggc gttttcaaat tccatttcag 237661 aatcgcaaat cggaacaaat aataataaat gaaagcaaac acgatcccga caggaatgac 237721 aacccagccg tttgtagaca gtccgtagtt caagacgtag tcaattcctc cgcctgagaa 237781 cgtatagccg tggcggacat ggaataaatc acaaacgaca aagatgacgc cggcaagaat 237841 agagttaatc aaatagagca cgggcgcaac gaacaagaaa gaaaactcaa ccggttctgt 237901 aattccggtc agcatagatg tgagcgccgc agaaatcatc acgccggaga tcattttttt 237961 cttttccgga cgcgcggtat ggataatggc aagagcaacg gccggcagac agaaaatcat 238021 gtaagggaaa tcccccatca taaagcgccc ggctgtcggg tctcccgcga aaaaccttgt 238081 caggtcgccg gttacggtgt tgcctgttga tgggtctgtg tattctccca tcataaaata 238141 gaaaggcgta taaaaaatat gatgcaggcc aaaaggaatc agcaaacgat agatcgttgc 238201 ataaaagaac aggccgactg ttgaatcggc aattaaactg ctggctgcgt taattccgtt 238261 ttggatcagc ggccaaacga atgagaaaat gacgccgatc accaatgaac tgacggaagt 238321 aatgatcggg acaaagcgtt ttccagagaa aaatccaagg accggatgca gctcgattga 238381 tgaaaatcgc ttatataaat aggcggcgag aagcccgata atgattcctc cgaaaacccc 238441 catatcaatc aggtgctcgg ctccttcata cggaggctga aggccgagta attttcccat 238501 attgtcgagg gtgacggtta aaattaagta tccgatgaca gcggcaagtc cggctacacc 238561 ttctccgccg gctaatccga tcgcgacccc cacggcgaaa atcagcggaa ggttatcgaa 238621 tacaacgccg cccgcatcct ttataatagg gatgttcagt aaatccttgt ctccgaaacg 238681 gagcaaaaga cctgctgccg gcaggacggc aaccggagtc atcaacgcgc ggccaagctg 238741 ctgcagaatt tgaaatgcct ttttaaacat gacagtctcc ttttattgtg ttatgagaat 238801 gatgcactct ttaatttttg agctgcttta taatcggcga taacggttac atgattgtgt 238861 ttttgaagaa tggaggctgg tacatctgtc gtgacaggac cttcagccat cttttgaatg 238921 gcgtctgctt tttcctcgcc gcttgctaaa agcacaatat gtttgctgaa ttccatgatg 238981 gttttaatgc ccattgaaat cgcgagtctc ggaaccagca ccggatcgcc gccgaagaat 239041 ctggcatttg cctgtatcgt gctttccgag agcttcacaa cacgtgtccg gtcttcaaaa 239101 tcagatcccg gttcattaaa accgatatgg ccattggcgc cgatgccgag aatttggaca 239161 tcaatgcctc ccgcctggcg gatgagatcc tcgtatactt tgcatgccgc ctcaagctgc 239221 ggattgtctc cttgcgggat atgaatatga tcaggctgca tattgatatg ctgaaaaaga 239281 tgctcatgca taaaatggtt ataactttgc ggatgagatg gagagagacc agcatattca 239341 tccaaattaa atgtagtaac ctttgaaaaa tcaatttcgc ctgcctgata gtctgaaatc 239401 aactgcttat acaagccgac cggtgtgctt cctgttgcca ggccgagaac ggcatctttc 239461 ttagcttgta tttgttcttt aataatggca gcgcttaact tacagagttc ttcgtagtgc 239521 tcggcgatca gaatcttcat gtgacacccc ctcaaagaga tagacaagca ccatatttgt 239581 tatgaccaat ttatgatact tgtcattacg aatttagcac cgcccttatc aaactgtcaa 239641 tattaatttc tgaaaatttg ttataaaaga aggatacaaa tctttcatat tgggagggca 239701 aatggtatta tggtctcaat gaaaaagaac ggattgcata cagaatgggg agaatgaaat 239761 gacagcttta tattctgtta tcaagtttaa aatcattgag ttaattaaat cgggcaaata 239821 tcaggcgaat gatcagctgc cgacggagag tgagttttgc gaacaatatg atgtcagcag 239881 aacaactgtg agactggctc tgcagcagct agagcttgag ggatatatta aaagaattca 239941 aggaaaaggg acatttgtat cggcggccaa aatacaaacg ccgattccgc ataagattac 240001 gagctttgca gaacaaatga gaggacttcg ttctgaatca aaagtgcttg agcttgtggt 240061 gattcctgcc gatcattcca tcgccgagct tttgaaaatg aaagagaatg aacctgtcaa 240121 caagcttgtc agagtcagat acgccgaggg ggaacctttg cagtatcata cctcatatat 240181 tccctggaag gcggcaccgg ggctggcgca ggaggaatgc accggctcgc tgtttgaatt 240241 gttaaggaca aaatacaata ttgaaatcag caggggcacg gaatcgatcg aaccgatttt 240301 aacggatgaa acgatcagcg gacacttatt aaccaatgtc ggagcgcctg cgtttttatc 240361 agaatccctt acctatgata aaaatgaaga agtggtggaa tatgcgcaaa ttattacacg 240421 gggagaccga acgaaattca ccgtagaaca gtcatatcat tcataaagca atgtgtttta 240481 agaagggaat ggtggttcta tgtttttatt tacgaatgga aaagtgctgt ggggagcagt 240541 gattgctgca ttcatccttt caattgtatt ttaccctttt ctgccgacgc agatgccgat 240601 tcattatgat gttgcgaaca gtccggatct gacggttaac aagctggcgg ggactgtgat 240661 gctgcctgtt ttgatggtgg tgtttgcatg ggcgcggaag atcaattggc aatttgtatt 240721 cgcagtgtat attttgctga tttgccacat tgtcgtcctt tgtttagcgc tctaaatcaa 240781 acagccagaa taaaactggc tgttttcttt aatttcagct tcatctgaca atgaatgtgg 240841 tgtataatag ctgatgatcc taaagaatat tctgaaattt ataggtgtga agcggcgtat 240901 tattaaagga aaggctgtat actttttgca gctttaaaaa gactgaatat ttaaacaatt 240961 atgtgaaagg tgtgctgatt agattgaata agcttattga acgagaaaaa actgtatatt 241021 ataaggaaaa gcccgacccg tcttccttgg ggtttggaca atattttaca gattatatgt 241081 ttgtgatgga ctacgaagag gggattggat ggcatcatcc gagaattgcg ccgtacgcac 241141 cgcttacgct tgatccgtct tcatctgttt ttcattacgg ccaggctgtt tttgaaggat 241201 taaaagcata cagaacagac gacggcaggg tgctgctgtt ccgtccggat caaaatatca 241261 aacggctgaa cagatcgtgt gagcgcatga gcatgccccc tttagacgaa gagctggtgc 241321 ttgaggcatt gacgcaatta gttgagctgg agaaagattg ggttccaaag gaaaaaggaa 241381 cgtcactgta tattcgtcct tttgtcattg ccacagaacc gagtctcggt gtgaaggcat 241441 ccaggagcta tacatttatg atcgtgcttt cgcctgtcgg ctcctattat ggcgacgatc 241501 agctgaagcc ggttagaatc tatgtcgaag atgagtatgt gagggcggtc aacggaggag 241561 tcgggtttgc aaaaacggct ggaaactatg ccgccagtct tcaggcacag cggaaagcga 241621 atgaactggg ctatgaccag gtactgtggc tggacgccat cgaaaagaaa tatgtggaag 241681 aagtagggag catgaacatc tttttcgtca taaacgggga agctgtcaca cctgctttaa 241741 gcggaagcat tttaagcggg gttacacgtg cgtctgcgat tgaattgatt cgaagctggg 241801 gcattccggt tcgtgaagag agaatatcga ttgatgaggt gtatgcggcc tctgcacgcg 241861 gagaattgac agaggtcttt ggcacaggca cggcagcagt cgttacgcct gtcggtgaac 241921 tcaacatcca tggaaaaacg gtgattgtag gcgacgggca aatcggggac ctctcgaaaa 241981 agctgtatga aacgataaca gatattcagc ttggcaaggt aaaaggcccg tttaactgga 242041 cagtggaagt gtgaaaatcg aaaaagaacc tgcccggagg caggttcttt ttattttgaa 242101 tgagtcatat cagcagccgg ctggcttttg cggtttttta cataatatat tgcatagcaa 242161 atggccataa atggaacgcc gcaatagagt gcgattcttt gattcggatc aaaggcaatg 242221 ccaacgacgg aagccaggca taacaggaac gcagcaatcg gcacgaacgg atacaaaggg 242281 gttctgtatt tcaaatcagt aaccttgttt cccgcttcga tataacgttt tctgaacatg 242341 aattgagaag cagcgattcc catccacacg acaacgacgg caaaaccgga aatcgacacg 242401 agcacaacgt atacagtgtc tggcgcaaat acgctggaca gcaacgacag aatgccgccg 242461 atcatgctga acaccagcgc gttaaaaggg gttccttttg acgtcagctt tgcaaatgtc 242521 ggatgaagcg ttttttcttt tgataaagac cacagcatcc gggaagaagc gtagagtccg 242581 gaattagccg ctgacaggat cgctgtcagg ataacaaagt tcatgatatc ggctgcgtat 242641 ggtacaccga ctctgtcaaa gacagcgaca aacgggcttt tgatgacacc tgcatcttga 242701 atcggaatca gccctgacag cacaaaaatt gttccgacaa agaagagcga gagacgccag 242761 accgttgttt ttatcgcttt tggtatcgtc ttgtcaggat caacgctttc accggctgcg 242821 attccgatta gttccgttcc cgaaaaggca aaattgacgg acagcatcgt catcaaaatc 242881 gggacaaatc cattgggaaa aagcccgcct tccgccgtga agttggacag catcggagcg 242941 gcttctccgc ctttgatcgg gatgatgccg aacatggcag agccgcctaa aagaataaat 243001 aatacaatgg ctaatacttt gatgctggaa aaccaaaatt ctgattcagc gaaaaacttg 243061 accgaaaatg cgttaagcaa gaagatgaac agcgcaaaga cggcactcca catccaaacc 243121 gatgtatggg ggaaccagcg ctgcattaac aggccggctg ctgtgaattc tgatcccaat 243181 gccacggtcc atgtcagcca atacagccaa gcgaccgtaa atccggtgcc cggccctatg 243241 tatttggctg cataggtgtg aaaggcgccg gtcacaggca tggcgactga cagctcaccg 243301 aggcatagca tgaccagata gacgatgccg gccccgacta agtaggcgag tatcgttccg 243361 gccgggcctg cttgctgaat ggtataacct gagcttaaaa acagcccggt tccgatgaca 243421 cctcccaagg aaagcataaa gaggtgccgg cttttcatac ttctctgaaa ggttgtctca 243481 ttcttgttgt gggcagagtt catctttttc caactttcta tcagcgattt atttccttcc 243541 taataaaaaa tctcatgtca gaaagtgaca cgagactccg gcgaaccggc tttaagttag 243601 aatatacaaa ctattccgat aagtcaagtt gtttttaaag agcgggccca agccgcaatt 243661 tcttgaatat tttcgggttt tgtccggcag cagccgccaa tcagcctcgc tcctttttca 243721 tgccaggtgc gggcgctcgc cccgtaagat tctgcgcatg ctgcgccgtt ccacgttttt 243781 gtttccggat catattgctc acctgaattc gggtagacaa tgatcggttt tgacgtgttc 243841 ttttttaact cctctatcaa ggaagggata tgctgaagcg gcgtgcagtt gatgccgagt 243901 gctgcaattt ggcggtgttc atcaagccac gatgcgcagt cagctgcagg tgttccgtca 243961 ctgatatgca agccgtcttt agcactgaag ctgatccatg catacgtttc aggaaattcc 244021 ttcaacagcc gaacaatcgc tttggcttca gtcagacacg gaatcgtttc gcatgccaat 244081 acatcagctc cggcttcaat cagcgccttc atccgggggc gatgaaattc aatcagttca 244141 tcttctgata ttgcgtagtt gccgcgatac tcagacccgt ctgcaagata agcgccataa 244201 gggcctatag aagccgcaat gatcggtttt ggccgattca aacggttctc ttcaagcgac 244261 caaaattcat cacgtgcttc agctgcgatg ctgacggaca actcgatgag ccggcgtgct 244321 tccgcttcgc tcagcccgcg tgcggcaaag ccttcaaatg tagactgata gctggcggtg 244381 attgcacaat cggcgcctgc cgcaaaataa tcagtatgaa cttgtttaat cagctccggc 244441 tcttccatca ggatttttgc cgaccacaga ctgtcattca aattacagcc cttgcgttca 244501 agctcggtcg ccatggcgcc gtctagcaca ataagcgggt atgtatctaa tatgtgttgg 244561 ataggattca tagaatgtac cgatgccttc tttcagattt ttttgaaaaa gatatgaaaa 244621 tcgtaatgga ggcttacgtg tttgtcaata aacgcaaaaa gagaaaggtg ttcagcccat 244681 atgtctgaac acccttttct tatgatattt gtttgttgtg cgtgtcagtc tttgtgtctg 244741 aaaccggcca gcactcaatg ccattatggt ttttgagcac atctttataa aagaccggat 244801 ccttgcctgc ttttttctgg cgtgtatagt ctttcagcgc cgtaaaaacg acctttgata 244861 gtaagaaaat cgcgattaaa ttcacgatga ccatcaaacc catgaacaaa tcagcaagat 244921 cccagacgag ctggactttg gcaacacagc caaacacgat cattgccagc acgccgatac 244981 ggtagacaaa aatcagtttt ttgcttttgt tcaaaaagcc gatattggtt tcgccataat 245041 aatagtttcc aattagagca cagaatccga ataacaaaat cagaatcgcg agaaagcctg 245101 atgcccatga tccgacatgg gagctgaggg aggcttgtgt caaggcgatt ccgctcagac 245161 ccggagtatg ataggcatcc gaaaacagaa tgataaaagc ggtgcttgta caaatgacca 245221 gtgtatctgt cagtacacca aaagcttgga tcagcccctg tttgacggga tggcttgttg 245281 tggcggtggc agcggcattt ggtgcgcttc ccattcccgc ttcgtttgaa aagattcccc 245341 gtctgacgcc ttgcatgagt gccgcgccca aagccccgcc ggcggcctgg tcaaaaccaa 245401 acgcattttt cacgattagc gcaagcacac ctggcagctg cgtaatgttg gagaaaatga 245461 cgaaaaacgc aactccgata tacaggacag ccaatacgac gacaatggat tcagccagct 245521 ttgcaatgcg cttgactccg ccaaaaataa tcgtgccgaa tacagcaatt aaaatgagtc 245581 ccaatgtcag gcggtttgtg ccaaacgcgt tttcaaaggc aaggctgact gtattggatt 245641 gaaccgagtt gaagacgata ccgaacgata aggtgattaa cacagcgaac agcgcgccca 245701 tccacctttt gttcagccct ttttccatgt aatacgccgg cccgccgcgg aagccgttta 245761 catcttttac tttataaatc tgagccagtg tgctttccac aaagctggat gctgatccga 245821 taatggcgat aatccacatc cagaagattg caccgggccc gccgagtgca atggcgatag 245881 caatgcccgt aatatttccc gttccgacac gggccgccat gctgatgcaa aaggcttgaa 245941 acggagaaat gctgtttttt gaccgggaag cagcaccttc tcttaatacc ctgaccattt 246001 ctttcagcat gcgaacctgt aaaaacttaa gcctgaacgt aaaatagatt ccaaaagaaa 246061 ggagcaaaac aattaatagc tttgaccaca aaagatcatt tgcaataccg acgatatgtt 246121 ctaggatttg ctgcatagaa tcacctcttt tttcatgttt aaaaaatgct gagctcccat 246181 tcctgcgcca tatgcttcag cagcataccg ccagtgaggc tgttgccgta ttcatcaatg 246241 gcaggcccgt aaatgccgat gccgcatccg gattgaaaag gctgttctct tctggcgctt 246301 ggaggcacca gcgccatgat gccgccggag acgccgcttt tggccggcac gccgacaaac 246361 gccgcatatt tgcctgaagc gttgtacatg ccgcacgtca gcattaatgc cttggccaat 246421 tttgccacat cttttggaat cacctgctcg tgtcgaatcg gatgataccc gtcatgagca 246481 aggatcaggc cgatcaacgc aatatcttct gtagtgctct ccatagcgca ttgcttcaag 246541 tacacctcaa gtgtttcttc tacttcagct tctaaaaagt ttgtttcttt taaatagtag 246601 gccagcgctc tgttgcggtg ggcggtttcc cattcagaac ggaatacttc ttcatgaatt 246661 cttggccgtt ttcctatcaa agtttccatc accgagtaaa gaaactcgag cttttcgtat 246721 gcagattctc cgggaaggat cgaagcgatg gtgagggcac ccgcgttgat catgggattg 246781 aagggctttc ccggcttgtt gatttcgagc cgaatgattg aattaaaggc gtcacctgtc 246841 ggctcgacat ctacgcggtc aagcacatag ggaatgccgc ggctcatgca ggcggcaata 246901 aagctaatca cttttgaaat gctttgcatg gtaaaagaga cgttccagtc gccggcgtgt 246961 atcatcgttc catcaggctc caatacacag atgccgagct gtgaatcatt gacttttcct 247021 aaagcgggga tatagtttgc gctttgtcca ttggcggcaa aagggcgata gtattcaacc 247081 caatcatgaa gctgtaacgc cgggtttatg tctttctggt gctcttttat caattctttc 247141 atcgaattcc tcctcactga tttttttctt aaaggactga ggtgtatcaa aacgaaggct 247201 aagggggcgt taaacgcttt cataatagcg gaaggtataa ttactgtata atggagacta 247261 cagaatcata caaaatacga caaaaacatt ttgaaaataa gcagtaagat ttataaaaac 247321 ctcatgttct gggtcaaaag caatttgcag gttttctccc gattccccaa aataaaaagc 247381 gaggatgtga tcaacataaa actggaacgg tttattgaaa aagacggata tatactggcc 247441 ctcatgctga ttacggtgcc gctggccggt gaactgaaat tttatcccct caatgaagaa 247501 ttccgggtca gctttggggc accggttttt ttcttctttt tatcattgtt gcggcatgtg 247561 cccgctgtgc tgccgggttt tctgactgga gcggctgttt tcatctttcg cgtctttctg 247621 gaattatggg gcggaggaca caatgggctg actccgattc tgtatgatca agcgtctggc 247681 tttttctttt atatgactta cgcctgtctg ttttccatat taaaggccaa tcgtttccgt 247741 gaacggccga ttatgctcgg tttcattggg tttatgattg aagttgtgtc agattgtgtc 247801 gagctaactg tgcaatttct catttttcat acggttgtca cgcctgagaa aatcactgac 247861 attgcggtga ttgcgatttc tcacacattt attgtgatga gcttttatag tgtgctgaag 247921 ctgtatgaaa cacaatcgag agaaaaacag acaaggcagc agcacgagca catgctgatg 247981 atcgtttcca atttatatga agaaacggtg cacctaaaaa agacattgaa aacgacagag 248041 aaagtgacaa acgattcgta tcagctctat cgggaaatga agggcaagga tgttcagctg 248101 agcggcagaa tcctgagact ggccggagag attcatgaag tgaaaaagga caaccagcgg 248161 atattcgcag ggctttcaaa actgatttcg aatgagagtt tgagagatta tatgagggct 248221 tctgatttgc tgcagctcgt gattcgaatg aatgaaaagt acgctgaagc actagggaag 248281 cagattgatt tttactgctc gatcgaggga gagcatgacg aatatcacgt atttatcgtg 248341 ctttcgatca ttaataatct aacagcaaat gcggtagagg ctatggatga agagggaatg 248401 gtcagcctga ggctccgtaa gccaaatgag agtatggtag aattccaggt ggaagacaat 248461 ggccccggga tttccgagaa aatcggagac attgtgtttg acccgggctt tacttcaaaa 248521 tatgacgaat ttggcacgcc ttctacgggt atcggacttt cctacgtaaa ggaaatcgtg 248581 acagagctag aaggggatat cacgtttgat aatcagcagc ggggagtggt gtttgccatc 248641 aggctgcctg tccggcattt gattcagaaa gggtgaacca aaagctatgc gtttttttat 248701 tgcagatgat gaccgtgcgg tgcggtcaat tttaaggcag atcattgagg acgaagatct 248761 cggggaagct gctggtgaag cagacgacgg aagccaagtg gaagggcata tgctgcaatt 248821 taagcagatt gatattttat taatcgatct gttaatgccc ggaagagacg gcattgagac 248881 gattcgtcag atccagaata cgtactccgg caaaatcgta atgatctctc aagtggaggc 248941 gaaggaaatg gtcggggaag cgtactcgct cggcatcgaa tattttatcc ataagccgat 249001 taaccgcatt gaaattgtca cggttctcca aaaggtgaag gagcggatcg agcttgaaca 249061 ctcgattgga gccattcagc attctctaag ccggcttgtc aatcggactg aacggaaagc 249121 gcgtccccag cagaagagtg acagcggttt aaaagaggca ggaacattcc tgttgtccga 249181 gctgggcatg atgggagaag gcggcgcaca tgatctcatg gcggtcctgc agtatttagc 249241 agaacacgag caatccgagc cgcacgaaaa acaaagccct tcgctaaaac aaatattcac 249301 ccaagtagcg gtacggaagc tggggacagg agcctcacag acggaagtca atcgcgaaat 249361 gaaagcctcg gagcagcgta tccgcagagc gattattcat tcgctgcacc attttgcttc 249421 actgggcaca actgattttt cgaatccaaa atttgaaacc tatgcatcga aattctttga 249481 ttttccggtt gtcagccaga aaatgaaaga actccaatcc aaggatgcaa aaccccttgc 249541 acctgctaga ataaatatga aaaaattcat ccacgtgttt tttttggaag caaagctttt 249601 gcatgagacg atgaaacaaa gaaggatata aaccaaacag ccggctgacc aggctgtttt 249661 tttgctgcgc agaatcccgg ccggacagtg atttaccgct tttttataaa atatcagaaa 249721 ataaagatat tgacttattg tttatttgtc ttacaattaa acaaaaggat atatgggaag 249781 gagcggatgt gaaagaaaaa ttaataaaag cgcttacaga tagaggccgt atacacaaat 249841 aacaggaggt tatgttgatg agccgtatca gaaaagcacc cgctggaatt ttaggttttc 249901 cggttgctcc ttttaacaca caaggaaaac tggaggaaga agctcttttt caaaacattg 249961 agtttttgct gaatgagggc ttggaagcga tatttatcgc ttgcgggtct ggtgaattcc 250021 aatctctcag ccagaaggaa tatgagcaaa tggtggaagt cgcagtctcg gcagccggag 250081 gaaaggtgcc ggtctacacg ggggtgggcg gcaacctcag cacagcgctt gattgggcgc 250141 agctgtcgga gaaaaaaggc gccgacggct acttgattct gcctccgtat ttggtgcatg 250201 gcgaacagga ggggctgtac cagtatgcga aaacgattat tgaaagcact gacttgaacg 250261 cgattcttta tcagcgcgat aacgcagttc tctctgttga acagatcaaa cgtctgaccg 250321 aatgtgaaca gcttgtcggt gtcaaagacg gggtaggaaa tatggatttg aatatcaatc 250381 tcgtctatac gatcggcgac cgcttgggat ggctcaacgg aatgccgatg gctgaagtga 250441 cgatgccggc ttatctgccg atcgggttcc actcttactc ttcagcgatt tcaaattata 250501 tcccgcatat ttcgcgaatg ttctatgatg cattgaaaaa cggaaatgac gagcttgtga 250561 aggaactcta tcggcatgtg attctgccga tcaacgacat tcgcaaacaa cgaaaaggct 250621 acgccgtatc cttgattaaa gccggtatgg aaatcatggg tttgaatgta aggaatacag 250681 ccagaccgcc tgtcggcccg gttgaaaaag atcattatca gcaattggaa gcaattttga 250741 agcaggcggc tgaccgtttt ccgaaaaaag ccgcgacggt ttgaccagaa aaaacacgaa 250801 aggggcaatg ggcatgtctg tgatcacgga acaaaacacg tacctcaact ttattaacgg 250861 agagtgggtt aagtctcaat caggcgatat ggtcaaagtc gaaaaccctg ccgatgtgaa 250921 tgatattgtc ggatatgtac agaattcaac ggctgaagat gtggaacgtg ccgtcaccgc 250981 cgccaatgaa gccaaaacgg cttggagaaa gctgacgggt gccgagcgcg gccaatactt 251041 atacaaaaca gcggatatca tggagcagcg cttggaggaa atcgccgcct gtgcaacgcg 251101 tgaaatgggt aaaacattgc cggaagcgaa gggagaaaca gcccggggga ttgccattct 251161 gcgctattac gccggagagg gcatgcgaaa aacgggtgac gtcattccgt ctactgacaa 251221 agacgcgctc atgtttacca cccgtgttcc gctcggtgtg gtcggtgtga tttctccgtg 251281 gaacttccca gtggcgattc cgatttggaa aatggcgccg gcattggtat acggcaatac 251341 cgttgtcatc aaaccggcga cagaaacagc tgtgacatgc gcgaagatca ttgcctgctt 251401 tgaggaagcg gggctcccgg caggggtcat caatttggtg acaggcccgg gttctgttgt 251461 cgggcagggg cttgctgagc atgacggtgt aaacgccgtt acgtttaccg gttcaaatca 251521 agtcggaaaa atcatcgggc aagccgcttt agcgagggga gccaaatatc agcttgagat 251581 gggcggcaaa aaccctgtca tcgtagctga tgacgctgac cttgaagctg cggcagaagc 251641 tgtcataacg ggggccttcc gttcaaccgg ccagaaatgc accgcgacaa gccgtgtcat 251701 cgtacaaagc ggaatttacg agcgctttaa agaaaaactg ctccagcgca caaaagatat 251761 tacaatcgga gacagcttaa aagaggatgt ctggatggga ccgatagcca gcaagaatca 251821 gcttgataac tgcctgtcat acattgagaa aggcaaacag gagggcgctt cccttttaat 251881 aggaggagaa aagctggaga acggaaagta tcaaaacggc tattatgttc agcctgccat 251941 ctttgacaat gtgacatctg agatgacaat tgcccaggag gaaattttcg gtccggtgat 252001 cgccttgatc aaggtggact cgatagagga ggcgctgaac atcgccaatg atgtgaagtt 252061 cggtttaagt gcatccatct tcacggaaaa catcggccga atgctttctt tcattgatga 252121 aatcgatgcc gggctggttc ggatcaatgc agaaagcgca ggtgttgagc tgcaggcgcc 252181 ttttggcggc atgaagcagt cgagctccca ctcccgagaa cagggtgagg cagcgaagga 252241 ctttttcaca gcgatcaaaa ctgtttttgt gaagccgtaa tggtgctgga aagaggcgtg 252301 cgtctctttc ccggtttatc acaaccagca tatgattctc tactttgaaa aggagaagat 252361 actatgaaaa aagactttgc gagtgttact ccggcgggca aaaaaacgtc cgtgcgctgg 252421 ttcatcgtgt ttatgctgtt tcttgtgacc tctattaact acgcggatcg agcgacgctt 252481 tccatcaccg gagattccgt ccagcacgat ttgggattgg actcggtcgc catgggatat 252541 gtcttttctg cctttggctg ggcctatgtc atcggacagc ttccgggcgg ctggctgctg 252601 gaccgttttg gttcaaagac tatcattgcg ttaagcatct ttttctggtc gttttttacg 252661 ttgctgcaag gggcgattgg ctttttctcc gccggcacag cgattatcct gctgtttgca 252721 ctgcgttttc tggttggttt atcagaagcg ccttcatttc ccggaaacgg cagagttgtt 252781 gcctcatggt ttccaagctc cgagcgcggg acagcttcag ccttttttaa ttcagcacaa 252841 tacttcgcaa tcgtcatttt ttctccttta atgggctggc ttacccactc tttcggctgg 252901 cattccgttt tcgttgtcat gggtattgca ggcattcttc tggctgtcat ctggctaaaa 252961 acggtgtatg aaccgaaaaa acatccgaag gttaatgaag ctgagcttgc gtacatcgaa 253021 cagggcggcg ggctgatttc catggatgac agtaaaagca aacaagaaac agaatcgaaa 253081 tggccgtata tcaaacagct gttaacgaac cgcatgctga ttggcgtgta catcgcgcaa 253141 tactgtatta cgactctcac ctatttcttt ctcacatggt ttccggtata tttggttcag 253201 gcccgcggca tgtctattct tgaagctggg tttgtcgctt ccctgccggc gctgtgcgga 253261 tttgccggcg gcgtgcttgg gggcattgtg tcagacatct tactcaaaaa aggccgttca 253321 ctgacctttg caagaaaagt gccaatcatt gccggcatgc tgctgtcttg cagtatgatt 253381 gtctgtaact acacagattc agcatggctc gtcgttgtca ttatgtcgct cgcgtttttc 253441 ggaaaaggct tcggcgcatt gggttgggct gtcgtgtcgg acacgtctcc gaaagaatgt 253501 gcaggattaa gcggcggttt gttcaacact ttcgggaata ttgcctcaat tacaacaccg 253561 attattatcg gatacattgt caatgccact ggatctttca atggcgcgct tgtgtttgtc 253621 ggcgctaacg cgattgcggc gatcctcagc tatttgctgc tggtcgggcc gatcaaacgg 253681 gtcgtgttaa agaaacaaga acaagacccc gatcaatcgt tgcctgtcta atatttatga 253741 aagcgcttta taaagggagg aaaatgcatg agttcaccga tacaagagca ggttcaaaaa 253801 gaaaaaagat cgaatattcc ctcaatttct gaaatgaagg tgattcctgt tgcgggacat 253861 gacagcatgc tgctgaatct aagcggagca cacagcccgt tttttacccg gaatatcgta 253921 atcttaacag acagcagcgg aaatcaggga gtcggcgagg tgcctggcgg agagcatatt 253981 cgccgcacac tggagctgtc agagccgctt gttgtcggaa aatctatcgg tgcgtaccag 254041 gcgatattgc aaacggtcag aaagcagttt ggcgatcagg acaggggagg gcgaggaaac 254101 cagacgtttg atttgcgcac cactgtgcac gccgtcaccg cactggaagc ggctttgttg 254161 gatttgcttg gaaagtttct tcaggaaccg gtcgcggctt tgctgggcga agggaagcag 254221 cgtgatgaag taaaaatgct cggttacctc ttttacatcg gcgaccgaaa tcggacgacc 254281 ttgccgtatc aaagcgatga gcagtcagat tgtgcgtggt tccgtctgcg ccatgaggaa 254341 gcgctgacgc cggaggccat tgtgcgtctt gccgaatccg cacaggagcg ctatggcttt 254401 caggatttca aattgaaagg cggggtgctg cggggagaag aggaaatcga agctgttacc 254461 gcattatcga aacgttttcc agaggcaagg atcactcttg atccgaacgg ggcatggtca 254521 ttagaggaag ctattgcatt atgcaaagga aagcaagatg tgctcgcgta tgcggaagat 254581 ccatgcgggg atgagaatgg ctactccgct cgtgaagtaa tggctgaatt ccgccgcgcg 254641 acagggcttc cgactgcgac aaatatgatt gcgactgact ggcgggaaat gggtcacgcg 254701 attcagctcc acgcggtcga tataccgctg gctgatccgc atttttggac gatgcaaggg 254761 tcggtgcggg ttgcgcaaat gtgccatgat tggggtttga catggggctc gcactccaac 254821 aaccactttg atatttccct tgcgatgttt acccatgtgg cagcagcggc tccggggcgg 254881 atcacggcga ttgataccca ttggatctgg caggacgggc agcgattaac gaaacagcct 254941 tttgagattt cttctggctg tgtcaaggtg ccggataagc ctggactagg cgtcgatatt 255001 gatatggaac aagtggaaaa agcgcatgag atctatcgga aaatgaattt aggcgcacgg 255061 aatgatgcga tcccaatgca gttcctgatc agcaactggg aatttgaccg gaagcgcccg 255121 tgtcttgtgc gataagtttg attgtaaata ttgtcatatc cgctattttg tcttacaatt 255181 gaacaactga agggagagtt gttcgtgtac gaaggtttag aggatttgaa agtcgataca 255241 gtcaatcgga aaacattagc caagcaggtc atcgaacgga ttgtccattt attatcgagc 255301 ggacagttga gggccggaga caaattgccg acagaaatgg aactgatgga cattttgcat 255361 gtcagcaggc cggtgctacg ggaagcactc agttcacttg aaacgctggg cgtcattacg 255421 agaaaaacac gagggggcac atatttcaac gataaaatcg gcatgcagcc attttccgtc 255481 atgcttgctt tggccactga taatcttccg gctatcattg aagcgcggat ggcgctagaa 255541 ctcgggctcg tgacaattgc cgcggaaaaa atcaatgagg aagagcttca gcgtttgcag 255601 aagacgatcg acgatattgc caacagcact gacaatcatt atggtgaagc ggataaagag 255661 ttccatcgaa ttattgcgtt aagcgccaat aaccccgtcg ttgaagggat gattcagtcc 255721 ctgctgatca cccatgcgaa aattgacagc caaattccgt acagggagag agatgtaacg 255781 gtcgaatatc acaaaaaaat ctacgacgcc cttgccaaaa gagatccgta caaagcacat 255841 taccacatgt atgagcatct gaaatttgtc cgtgacaaaa ttctaaaagg aatggatgaa 255901 aaataatggt gagcaaccgc agttgaaacg taagagctgc ggttttttta aaccaattta 255961 gaaaacgctt actaaaatat gaggagtgat tttcatatgg cgatgaacct caggaagaac 256021 caagcccccc tttacatcaa agtgcatgaa atagataaca ccgcgattat tgtaaatgat 256081 ggagggctgc caaagggcac tgttttctca tgcgggctcg tacttgaaga ggatgttcct 256141 caaggccata aggtggccct caccgatctc aatcaagggg acgagatcgt gcgttacgga 256201 gaggtgatcg gatttgctga tgagacgatc aaacgcggga gctggatacg ggaagccctc 256261 gtgagaatgc ccgctcctcc ggcgttagac gatcttcctc tcgcaaacag ggtgccgcag 256321 ccgcggcccc cacttgaagg atatacattt gaaggatacc gaaatgcgga tggcagtgcg 256381 gggacaaaaa atatcctcgg catcacgaca agtgttcaat gtgttgttgg cgttttggat 256441 tatgcagtca aacgaataaa agaagagctg ctgccgaaat acccaaatgt cgatgacgtt 256501 gtgccgctgc atcatcaata cggatgcggc gtggcgatca atgcgcccga cgctgtcatt 256561 ccgatccgca cgattcaaaa tcttgcgaag catccgaact tcggcggtga agtaatggta 256621 atcggattgg gatgtgaaaa gctcctcccg gaaagaattg cctccgaaaa tgatgatgac 256681 attctatcgc tccaggatca ccgaggtttt gcggcgatga tccaatccat tttggaaatg 256741 gcggaggaac ggttaatcag gctgaacagc agaacccggg tgtcatgccc tgtttcggat 256801 ctggttatcg gcctgcaatg cggcggcagt gatgcgtttt ccggcgtgac ggcgaaccct 256861 gccgtggggt atgcggctga tttattggtt cgcgcaggtg caacggtttt gttttctgaa 256921 gtgacagagg tgcgggatgc cattcattta ttaacgccgc gggctgtcag tgaagaggtc 256981 ggacaatcgc tgatcaaaga gatgaagtgg tatgacagct atcttcggcg gggagacgca 257041 gaccgtagcg caaacccgtc accaggcaat aaaaaaggcg gattatccaa tgtggtggaa 257101 aaagcgttag gttcggtagc gaaatcaggc acaagcccca tctccggcgt gctcggccct 257161 ggtgaaagag caaagcaaaa aggcctgctg ttcgcggcga caccggcaag cgattttgtg 257221 tgcggcaccc tgcagctggc tgcgggcatg aatttgcagg tgtttacgac agggagagga 257281 acaccatatg gcctggctgc tgcgccggtt ctgaaagtat cgacgcggca ttccttatca 257341 gagcattggg ctgatttaat cgatatcaat gccggccgaa tcgcgacagg agaggccagt 257401 atcgaagacg taggctggga aatcttcagg acgattttgg atgtggcaag cggccgcaaa 257461 caaacgtggg cagaccgttg gggtcttcat aatgatttgt gcttgtttaa tcctgctcca 257521 gtgacttgat tcatgttttt atagcggaaa gatggaatat gctgtaaaat gaaaatcagc 257581 gtataggaaa cggaggggtt acagcatggc attcattaga ttccgagtga cacgaattca 257641 atagtgaaca actctcgcct gaatgcgaga gaatcgggat gaatccgcct atgtatgagc 257701 ccttatatgg ttatcaaaaa agagggtggc gtgcctgccc ttttttgtgc cttcaagcat 257761 cccttctctc tactgcaggc cggagcatga gaaaggggaa atgggatgac aaaccttaac 257821 gaaaaacagc ttatcactga gattgtcggg cttgcacgca gccaaggttt gacggttcat 257881 tctgagaacg cgcaattgaa tgaaaccgga atggactttc aagttgtatt tgccaaggac 257941 gacacaggta tgccatgggt gctgcgaaaa ccgcggcgaa gtgatgttgt ggaaagagca 258001 tctgcagaag gcataacgct tgcctttctc cgcgcgaatc tgactgctga tgtgccggat 258061 tggagaattc atacaccgga attgatcgct taccccatgt taaaaggaac gccggctgct 258121 ggaattgact tggaacaaaa gcaatatgta tggaatatgg atcatcagcc gccgtcagac 258181 gactttgtcc gcacacttgc cgacatactg gctgaattac atggcacgga tcaaatatct 258241 gctgggcaat ccggaataga agtgataagg ccagaagatt tcaggcaaat gacagcagac 258301 tctatggttg atgtgaagaa taagcttggc gtatctacga cgctttggga aagatggcaa 258361 aagtgggtag atgatgatgc atactggccg ggtttctctt ctttgataca cggcgatctc 258421 cacccgccgc atatccttat cgatcaaaat ggacgtgtca caggacttct ggattggaca 258481 gaagcgaagg ttgctgaccc agccaaggat tttgttcttt atcaaaccat tttcggagaa 258541 aaagaaactg cccgtttgct tgaatactat gatcaagcag gcggccgaat atgggcaaaa 258601 atgcaggaac acatctcaga gatgcaggcg gcgtatccgg tggaaatcgc caagctagct 258661 ctgcaaacac agcaggagga acacatcaat atggcgctgg aagcacttgg tgtaacatcg 258721 gattaagaat tgacttcgtt tcatgaaccg agtattataa actctacaaa taatagaacg 258781 gattaacaat cgtgaggaag agcaagtacg catcagaatg gaggttcaga gagtcggtgg 258841 caggtgtgaa ccgatcctcc cctgatgccg aatgggcttc tgaattgctt tgctgaacgg 258901 atagtaggcg atgccgggtt tctctccccg ttaccaagag aggagtatcg aaacataggt 258961 tttctgtact tagagtgaac ggctgtatag ctgttaataa aggtggtacc gcgagaccct 259021 cgtcctttgc ataggacggg ggttttttgt gtttcttaaa ggaggtgacg gccaatgtac 259081 gatggctggt ggtggcatag cagatgagtt agaaaggagg atatcaaatg gtcattgcaa 259141 ctgatgatct tgaggtcgca tgtcctaaat gtgaaagagc gggagaaatc gaaggaacac 259201 cttgcccggc ctgcagcgga aaaggtgtta ttctgactgc tcaaggatat acgcttctcg 259261 attttatcca aaagcatttg aataagtaaa ggagaaaagc tgagctgaga tgagagcaga 259321 agagcagagt aagattcgtg aggccgcagc aggtacgatt tttttgctga tcggaacagt 259381 ttgttttgcg tctaaatcga tttggataaa atgggcatac caaatgggtg ctgagccaga 259441 tgccgtgctg ctatacaggc agctgctggc tgttccgctg ttttggctga tttttttaat 259501 ataccgtcct ccaatgccag acggtaagaa aaaaggagac ctatggaagg cttgtggcgc 259561 gggagtgttt tgtttttttc tgtctccctt gcttgatttt atcgggctga accatgtatc 259621 cgcaatggtt gaacgtatat tgctgatgag ctatccgttg tttgtgtttg gattcaccgc 259681 gtgtcgtgac cggaaaatgt cctcaattca ggaccttttc gcagttctgg cggtcatgtt 259741 tgggcttttc ttggcgctgg gcggctggaa tgctgagctt ttccaggcga atatgattgg 259801 agctgtattc attttgttat cttcggccgt ctatgctggt tatcttgtcc tttccgggca 259861 tctcgtccat caaatcggag ggatccgtct caatgcatac gggatgacag ctgctggagc 259921 tgccatgatg ctttacacag ggataaaatc ggcggctggc atgaatacgc caatggcagc 259981 atatccgctt tctatgtatg gtttgttcgc agtaattgca gtcgttacca cagtgattcc 260041 atttgtgcta atgcttgagg gcataaaacg aatcggggca cagcgagccg ccgccatttc 260101 aatggcaggg cctatcctga cgattttcta tggagcttta tttctcggtg aacggctcgg 260161 gctcattcaa gtcattggat gcggtggcgt attttttgtc attacgggca tggaatacag 260221 gaagctgaaa acaggaaaaa aagaataatt tttataaaac acacacgttt ttcaattaca 260281 ataagtgtaa ttacgtgtgt gttttttgat tttgtaaagg ttaggtgagg agatgcagcg 260341 catattgctt gtagaagacg accactcaat cagtgaaatg gtggatcatt atttaacaaa 260401 agaaggcttt ggaattgtgc atgctttcga cggagaagag ggcatccggc tgtttcagca 260461 gggttcatac gatttggtcc tccttgatat catgctcccg aagctgaacg gcatggattt 260521 tctgaaaatc atccgggaaa aaagcaatat accggtctta atgatttcgg caaaagatgg 260581 agatgtggac aaggcattgg gactgggctt tggggcggat gattatatcg ccaaaccgtt 260641 ttcgatgatt gagctgacag cccgagtaaa agccgcgata cggcgggcga cgcaatattc 260701 ggcagaggag ccggctgtga ataaggtgat ccggattcac cagcttgcga tagatataga 260761 caatgtttcc gttttgaaaa acggagagcc gctccagctg acgtcaacag aatggcagct 260821 gctgtgctta tttgcatcaa atcctaaaaa agtgtttacg aaagaacaaa tctaccgttc 260881 cgtttggaat gaagagtact ttgatgatca gaacatcatt aacgtacata tgcggcggct 260941 cagagaaaag attgaggatg acccctcctc ccctcaatat attaaaacgt tatggggcat 261001 cggttataaa ttaggagagt tttagaatga cagtgctatg ggtggccgct gtcatcgctc 261061 tggcgtgtct gaatgtgatt caattcataa tgaaaaagaa gcgggacggg aatctggctt 261121 acacggctga ccagcttagc tacatgctca gccgggattc ggcaggacaa attttgcttc 261181 ctacagacga tcatgcgctc aaagacttgc ttgttaacat caatcttatc gttgagaatc 261241 gtcagcagat cagcgcccaa tttgccaaaa cagagcaatc catgaagcgg atgctgacca 261301 atatgtcgca cgacctgaaa acgccgttaa cggtcattct cggttatatt gaagccattc 261361 aaagtgaccc gaacatgccg gacgaagagc gggaaagatt gctggggaag ctccgccaga 261421 aaacaaatga acttattcag atgatcaatt ccttttttga tttagcgaaa ttagaatctg 261481 aagataaaga gatcccgatc accaaagtac atatgaacga catatgcaaa cgaaatatcc 261541 tgcactatta tgacgctgtt cagtcaaaag gctttcaagc agccatcgat atccccgata 261601 cgccggtgta tgcgcaggcg aatgaagagg ctctggacag aatcctgcaa aacctattgt 261661 ccaatgcgat tcaatatggc gcggccggca agttaatcgg gctgacgctg tcttatgatg 261721 agaggaacat cgccatcacc gtatgggatc gcggaaaagg gattagtgaa accgatcagc 261781 agcgggtgtt tgagaggctg tacacactgg aagaatccag aaataaagca tttcaaggaa 261841 gcggcttggg tttaaccatc acaaaacggc ttacagaaaa aatgggaggc atcatatccg 261901 tccaaagcaa gccgtacgaa cggactgcat ttacgatcac attgaaacgc atgacatatt 261961 aatcgtaaga atttcttaag gtttgagaaa taaaaatgac agggctcgcc gctacaatag 262021 aaaacaggaa aagagaggga aggagaaaca aagttgactt atatcgtaca aacaaacggg 262081 ctgaccaaaa catatcaggg caaagaggtc gtatccaatg tcagcatgca tattaaaaaa 262141 ggtgaaatct atggctttct cggcccgaac ggcgcgggga aaacaaccat tatgaaaatg 262201 ctgacgagcc ttgtcaaacc gacaagcggt gaaatcatca tccttgggaa caagttcacc 262261 cacacgtcat atgaggtgct ggggaacatc ggcagcatga ttgaatatcc gattttttat 262321 gaaaacctga cagctgaaga aaatttagat ctgcattgtg aatatatggg ataccacaat 262381 aaaaaagcca tacaagaagt gctggatatg gtgaatttaa aacaaatcga caaaaaaccc 262441 gtcaaaacct tttccctcgg gatgaagcag cgccttggaa ttgcgcgtgc catcctcacg 262501 aagccggacc tgcttattct ggatgagccg gtgaatggtc ttgaccctct cggcattaaa 262561 aagatcaggc aattgtttca agtgctgagc aaagagtacg ggatgacgct gctgatctca 262621 agccacctgc tgggtgaaat cgaacaaatc gcggacacaa tcggcgtcat tcgggacggc 262681 aggctgcttg aagaggtatc aatggaggat gtcaggggcc agaacactga atacatcgag 262741 cttgtcacgc cgaatcagac aagggcctgc tttgtgctgg agaaagagct gcaattaacc 262801 aactttaaaa tattaaatga gaaaacgatt cgaatttacg aggctgaagc ctctcaggct 262861 gccatatcca aagcattgat tttaaatgat gtagacattg aatcaatgaa caaaaagtat 262921 acgtcgctgg aggattattt tatcaaattg atcaacggca atagcatcag tgcgtaaagg 262981 aggagagaca cgttgatgaa tttgatcaga atcgaattaa gaaaaatgaa aatgggctgg 263041 tatatcagag gtgccctcat tgccaacgtg atcattatgg gttttatgtg gctgatcagt 263101 tattccgaaa aagccgatgg cggggtttcg ttccaaagta cggatgaagc attcctcatc 263161 atcggcacct tcgtcagagc ggtatttatc gtatttggcg ctgtgctgat cgtaaaattg 263221 gtgatttcgg aatataaaaa caaaaccatt cttgtgatgt tcacgtaccc gatcagccgt 263281 aaaaagctgc tcaccgctaa gctcatgatc gcgggcggac tgacgtttat cacgatttta 263341 ctttcaaata tactcatagc cgccggtttc ttttggctga actcgatctg ccatttcata 263401 ccgggagagc ttacttccga gatcatttct caacaggcgg tcaaaatggc ggttttcgct 263461 tttggcgccg ctggaaccag tttagttccc atcttttttg ggatgcgtag acactcggtt 263521 ccggcgacca tcatttcatc tgtagtaatt gtgatgctca tcagctcaac aagtccgggc 263581 ttctcgattt catctgttgt gtatatcccg ttatcgttag cggcattcgg tttgttcttt 263641 tcctacatgg cgatcaggaa tgcggacaag caggatgcgt aaacaaaggc gcccaatatg 263701 tataaaaggc cgatgctgtc agcaccggcc tttccattat gagtctgttc ttgtttcaag 263761 ataatgcttc ttgccaatct ctttgctcat catatagaaa tggaagcaat attcaccgat 263821 tgccatgacg atcgcgccga ataaagccgc caatgcaact tcaccgccag tcatccccat 263881 agaaagcggc atgcccatca gccagatcac gagaaaggcc aaaccaaaat cagccaaagt 263941 tgcaatcata ttattccatt tcggcaatac ataaagatcg cccagcaaat aagaaataac 264001 ccctaacaca atcgtcatta gcagcgtatc accaaacgtg aaaccaaagc ccagaccaag 264061 caccagatac aacacaataa tcgtcataat acctttaata gcgagcgctt tcacatgtgt 264121 cattacaatt cctccttttg tcatttgatt tgttatgtat aattcctcaa atgtaaaaag 264181 ttaaacctta tttcttttcg gaggcgggtg caaatctgct ggggagaggt caatgatgtg 264241 aatccaggaa ttgaggctgc ggcgcttcga cagcggaaac gtgaagcttg tactgcaccg 264301 gacgctgctt tgatgcccaa cagcccatta tgtttgctgt ttttagatga ataaatttaa 264361 aaacttctcc tgtccctccg tcatcacttc tgaagtaatg aaatatgatg aaaagagatc 264421 aaggggaggt gacgtgatgg cggtcgtgag agcaacgagt gcggatgtcg atttgatggc 264481 aaggctgctc agagcggaag cggaaggcga aggcaagcag gggatgctgc ttgtcggcaa 264541 cgttggaatt aatcggctgc gggcgaattg ctcagatttt aaaggcctcc gcaccatcag 264601 gcagatgatt tatcagccac acgcgtttga ggctgtgact catggatatt tttatcaaag 264661 ggcgcgagat agcgagcgtg cccttgcacg ccggtcgatt aatggtgaaa ggcgctggcc 264721 tgcaaaattt agtttatggt acttcaggcc gcagggggac tgtccagccc agtggtataa 264781 ccagccgttt gtggccagat ttaagtcaca ctgcttttat cagccgacgg cggagacgtg 264841 tgaaaatgta tataacacat tttagagaca ggacaccgtt caaattgaac ggtgtttttc 264901 tttgaaaaga tgcaatgcaa aatattcctg tgagataatc aaagaaaaaa gagctgacgg 264961 agatgacaga atggcaacaa ttgacctgca aaagaaaagt gtaaagatcg tactggagaa 265021 aaagcagtta acgaaggtga cggctcgtgt tggactggtt cttgatatta cgggatcgat 265081 gagaccgctc tacaaaaacg ggacggttca aaatgtggtg gagcggattt tggcagtggc 265141 tgatcagttt gatgataacg gtttgctgga tgtatgggtg tatgataatg aattttcccg 265201 attaaagcca gtttcagaaa aggatttttc gggctatgtc gatcgtgaaa ttttaaataa 265261 tgaccgcttg cataaattcg gcagaaatga tgagccgcca gtcatgaagg acgtgctgcg 265321 caaatatgtt acggaggaac cgagctcgta tcctgctttc attgttttta tcaatgacgg 265381 gggctgtaaa aagtcaatca aaccgataat tgaagcttct tctgataaac cggtgttctg 265441 gcagtttgtc ggcatcggaa acggaaactt tgattttctc aataaactgg atacgttaga 265501 agggcgtgtc attgataaca cgaacttcct gcatatcgaa gagattgacc gcatttctga 265561 tgatgagctt tatgatgctc tgcttgctga atttccattt tggctgaaag aagcgaagga 265621 aaaagggatt gtaagagaac aagagcctcc tgctgaaaag ccgaaaaaga agggcttttt 265681 cagcagattg ttttcgaaat aactgataaa gagcactgag tcattctgcg aaatggctcg 265741 gtgtttttgt ttttttaaga tcatgtgaag aaaaataggc cgaatgggcg gcttgcaaac 265801 gacaggatat gcagaaaacg cgtcattcag ccagctttcg gcatgtttca gcagcaggct 265861 tgtgagggaa gacctgtttt taatgttcag cgcttacaat cagttcacac ttcttcacag 265921 tcgtttaaca atgatttcct ataatggaga cgatcaatga ggagagaggg gatcttgaat 265981 ggcatacgac agtcgttttg atgaatgggt acagaaactg aaagaggaaa gctttcaaaa 266041 caatacgttt gaccgccgca aatttattca aggagcgggg aagattgcag gactttctct 266101 tggattaacg attgcccagt cggttggggc ctttgaagta aatgctgcgc ctaacttctc 266161 aagctatccg tttacattag gggtagcgtc aggtgatccg ctttctgaca gtgtcgtgct 266221 ttggacacgt ctggcaccag atccgctgaa tggcggggga atgccgaagc aagcagtgcc 266281 tgtcaaatgg gaggtcgcaa aggatgagca tttccgcaaa atcgtaagaa aaggcactga 266341 aatggctaaa ccaagtcttg cccattccgt tcatgtggaa gcggacgggc ttgagccaaa 266401 caaagtgtac tattaccgtt tcaaaaccgg ccatgaacta agccctgtcg gaaaaacaaa 266461 aacactgcct gcccctggcg ccaatgtgcc gcaaatgacc tttgcatttg cttcctgcca 266521 gcaatatgag cacggatatt atacggccta caagcatatg gcaaaggaaa agcttgatct 266581 tgtcttccat ctcggtgatt acatatatga atacggccca aatgaatatg tatcaaaaac 266641 aggcaatgtc cgcacgcaca acagcgcgga aatcattacg ctgcaagact atcggaaccg 266701 tcacgctcaa taccgttctg acgccaatct taaagctgca catgcggcat tcccttgggt 266761 tgtaacttgg gatgaccatg aagttgaaaa caactatgcc aataaaatac ctgaaaaagg 266821 acagtcggtt gaagcattcg tgctccgccg cgcggcagca taccaggcat actatgaaca 266881 tatgccgctc cgcatttcct ctttgccgaa tggcccagat atgcagctgt accggcactt 266941 tacgtacgga aacctggcgt ccttcaatgt gcttgatacc cgccagtaca gggacgacca 267001 agccaataac gacggcaata agccgccttc tgatgaatcg cgcaatccga atcggactct 267061 gcttggaaaa gaacaggagc agtggctctt caacaatttg ggcagctcga cagcccactg 267121 gaatgtgctg gcgcagcaga ttttctttgc caagtggaat ttcgggacaa gcgcaagccc 267181 gatctacagc atggattcgt gggacggcta cccggctcag cgcgaacggg ttatcaattt 267241 cattaaaagc aaaaatctga ataatgttgt cgtactgaca ggtgatgtac acgcaagctg 267301 ggcatcgaat ttgcatgtcg atttcgagaa gacaagttca aaaatattcg gagccgaatt 267361 tgttggaacc tcgatcactt ccggagggaa cggagcggat aagcgagcgg atacggacca 267421 aattttaaaa gaaaatccgc acatccagtt ctttaacgac tatcgcggat atgtccgctg 267481 tacagtgacg cctcaccagt ggaaagccga ttatcgggtg atgccatttg tgaccgagcc 267541 gggcgcagcc atttccacgc gggcttcatt cgtttaccag aaagaccaaa ccgggttgag 267601 aaaggtatca tccacaacaa tccaaggcgg ggtgaagcaa tccgatgagg tcgaagagga 267661 tcgtttcttt tcgcacaaca aagcccacga aaaacaaatg attaagaagc gtgcaaaaat 267721 cacgaattaa ggagtggaaa ttatgttttc aaacattgga ataccgggct tgattctcat 267781 cttcgtcatc gccctcatta tttttggccc ttccaagctg ccggaaatcg ggcgtgccgc 267841 cggacggaca ctgctggaat ttaaaagcgc cacaaaatca cttgtgtctg gtgatgaaaa 267901 agaagagaaa tcagctgagc tgacagcggt aaagcaggac aaaaacgcgg gctgaatgct 267961 gatgaggcag acaccgggtc tgcctctttt tttatgaaag ggagggcttt tttgaatgga 268021 taaaaaagaa acccatctga tcgggcattt agaagagctt cgccgccgga ttatcgtcac 268081 ccttgcggca ttttttctat ttctcatcac ggcttttttg ttcgtacagg acatttatga 268141 ctggctgatc agggatttgg atggaaagct ggctgtgcta ggaccgagtg aaatcctctg 268201 ggtgtatatg atgctttccg gcatttgtgc cattgcggct tctatccctg ttgccgcgta 268261 ccagctgtgg cgtttcgttg caccggcgct gactaaaacg gagcgcaagg tgacgctcat 268321 gtacatacca ggtttatttg cgttgttttt ggcgggcatc tccttcggat actttgtctt 268381 gtttccgatc gtgctcagct ttttgactca tttatcctcc ggccactttg aaacgatgtt 268441 tacggctgac cgctacttta ggtttatggt gaatttgagc ctgccgttcg gcttcttgtt 268501 tgagatgccc ttggtggtga tgtttttaac aaggctgggc atcttaaatc cttacagact 268561 ggccaaagcg agaaagcttt cctattttct gctgattgtc gtgtccatat tgattacacc 268621 gcctgatttt atttctgatt ttctcgtgat gatcccgctt cttgtcctgt ttgaagtgag 268681 tgtcacccta tcggcgtttg tctacaaaaa gaggatgagg gaagaaacag cggcggccgc 268741 ttagtgcagc gtaccacccg gtgacttcac atcctcatca tattgtgcgg ccgtaacagc 268801 ggcgattctc aatgcccgga caatcgtgtc caggctgagg ctcggcgctg ttttgtcgat 268861 tgtttgctgc ggaatgtaag gaatatgaat aaaaccgccg cgaatgtgtg gggatgtccg 268921 gctaatgtga tccattaacc cgtagaacaa atagttgcat acaaaggtcc ccgctgtgta 268981 ggaaaccgca gctggaatgc cgtgttcctt catcttagca gtcattcgtt tcacgggaag 269041 ccttgtccag taagcggcgg gcccatctgg agaaatctct tcatcaatcg gctgatgtcc 269101 ttcgttatcg gggattcgcg catctgcaag gttgattgcc actcgttccg gtgtaatctg 269161 catccgtcct cctgcttggc cgacacaaat tacgatatct ggctgatgtt tttgaatggc 269221 ttggcgcaga gtgtccagag cggatctaaa gacggttgga atttgttccg ctgtaataat 269281 ggcttcttct gtctcgaagc cattaagccg tttcgccgct tcccatgatg gattgacggt 269341 ttctttgtca aaagggtcaa agcctgtgat cagcactttt tttctcattc tcccatctcc 269401 tttttctttt attctattgt ttatttatgg gtttttcatc aaaataatgt aaaggagtga 269461 atcataatgg agcatttgcc ggagcagtat cgccagttat tcccaacctt gcagacgcat 269521 acgatgcttg ccagctgttc tcagagcgca ttggcagagc ctgtatcaag ggcgatccag 269581 gattattatg atagcctgct gtataaaggg acgaactgga aagaagcgat tgaaaaaaca 269641 gagtttgcga gaaacgagtt tgcaaagctg atcggggctg aaccggatga agtggcgatt 269701 gtgccgtcag tttctgatgc actggtttct gtagcatcgt ccttaactgc atttggaaag 269761 aagcacgttg tatatacaga tatggatttt ccggcggtgc ctcatgtttg gcaggcacac 269821 tccgattata ccgtatccgt cattccatca atagacggcg tgctgccgct tgaacaatat 269881 gaaacgcata tttcggatga aacagtactg acgtgtgttc ctcacgttca ttatcgtgac 269941 ggctatgttc aggatataaa agcgattgcc gagatttctc agagaaaggg ctctttattg 270001 tttgtagatg cttatcaatc agccgggcat attcccattg atgtgaagga atggggcgta 270061 gatatgctgg cagcaggcac ccggaagtat ttgctcggca taccgggtgt ggcgtttctt 270121 tatgtgagaa aggagctggc tgacgcactg aagccgaaag catcagcttg gttcggaaga 270181 gagagcggat ttgatggggc ttatgcaaaa gtcgcgcgcc gttttcaaac gggcacccca 270241 gcttttatca gcgtatacgc agctgcagcg gctttatcgc tgctgaatca tattggggtt 270301 tctcatatca gggatcatgt gaaaacgatc tgtgccgatg cagttcaata tgccgctgaa 270361 aaaggcctgc agctggcggc ggcacaaggt gggattcagc cgggcatggt tgcgatccgg 270421 gatgagcggg catcggaaac ggcggggttg ctgaagaaga aaaaagtgat ttgcgcgccg 270481 cgggaaaatg ttatccgtct cgctccccat ttttataata cgaaggagga aatgcggcac 270541 gcgattgatg aaatcgcggc gaaaacgatc cacaagtaaa catgaaaaag cccctgaaca 270601 ctagtcaggg gcttttcata ttaatgatct actttaacgc gtttcataaa gaaagcgcca 270661 attaaaccga taatggcaac aatcattgca aacacaaatg cgtgctgtac gcctgctgtc 270721 aaagcttgcg ggatgactgc cggatcggca gggtttttaa ctgtactcat ataatcatgc 270781 tggcctgcag ccataatgct gaccgcaacc gctgttccga tagcgccggc catttgctgc 270841 agcgtgttca taatggcggt gccgtctgga taaaattcac gcggcagttg gtttaaaccg 270901 tttgtctgtg caggcatcat gatcatagaa atcccgatca tcaagcaggt gtgcaggatg 270961 ataatcagca cagctgttga agtggtcgtg acatttgaga agaaccatag tacaacggtg 271021 acaatcacaa atcccggaat gacaagccat ttcggcccgt atttatcgaa caagcggcct 271081 gtaacagggg acataaatcc atttaaaata ccgcccggca agagaacaag accagatgca 271141 aatgcagtga ggactaagcc gccttgcaga tacatcggca gaagcagcat agatgacaga 271201 atgaccatca tacaaatgaa caccatgatc acacccaaaa taaacatcgg gtatttgaac 271261 gcacggaggt tcatcatagg ctgcttcatt gtcagctggc ggattgaaaa taagataagg 271321 ccgacaacgc cgacaatcag cgacacgata acagtcgggc tggaccatcc cccggagcct 271381 tcacccgcgt tgctgaatcc gaatacaatg ccgccgaagc caatcgtcga caggatgata 271441 gacaatacat cgattttcgg ctttgtcgtt tcagatacat tttgcatata tgcgataccg 271501 aaaacaagcg ccagcacaag gaatggaaga gagatccaga aaatccagtg ccagttgaga 271561 tgctccagaa ccaatcctga gaaagttggg ccgatggcgg gcgcgaacat aatgacaagc 271621 ccgatcgttc ccattgcggc accccgttta tgaggcggga aaatcaccaa gattgtgtta 271681 aacatcagcg gcagtaaaag accggttcca agtgcctgaa cgatccttgc cgctaataaa 271741 aacgagaagc tcggcgcaag cgccgcaatg aatgtaccta aaattgaaaa gataagtgac 271801 acggtaaaaa gctgtcttgt tgtgaaccac tgcaacagca gtcctgaaac aggaacaagg 271861 ataccgagta caagcaggta gcccgtcgtt aaccattgga cggttgccgc tgtaatgttc 271921 aattccttca taaggtcggt taacgcaata ttcagcgctg tttcactgaa catgccgata 271981 aaaccggcca acagcaagga aatcataatc ggcatcactt tgtattgctg agatgcttta 272041 gctgttgttt ccaaaatcat ttcccctctc tatcaactgc atgtagtatg tcgttttttt 272101 tatctcttca gcaggtcagg aatgcagctg gagatatgaa ggagcggcgt actgtttttt 272161 gccgtcaaag ataaaaggat gccgccttca atcatcgcgt taaccacagt gctggcttct 272221 tttgcacggc tctcgctgca gccagtctgc cgcagttttt cctcatacac agaggcccat 272281 tctttgtagg cttcatgaca ggcttcgcgc aacggttcgc ttttcaatga cgtctcagcc 272341 gctagcaagc ccacaggcaa gccttcaatg tcttccgtac atgaaaactg gcaggagagc 272401 tccttcaaaa aggcttgaat gccttccgct ggatcggtgc aggcttccat gcagtccgcg 272461 attttctgac ggatatactc cttcatctca ttcacggctt cgatcgcaag ctgttcttta 272521 cccccgggaa agtggtagta aagagagcct ttaggcgcgc cgctttcctt tataatctgg 272581 ttcagccccg tgccgtaata cccttgcagc tgaaaaagcc gggtagctgc cgaaaggatt 272641 ttctcacggg aatctccata actcataaca ttcccacctt actgaattgc aatcaaaaat 272701 atagtgactg gtctattatc ttgattcaat catcaattgt caagaaaaat tcattgtatg 272761 aaaagacaaa aaaagaagga tatgacaaca aaaaatactg agagaaaagc tgactgatct 272821 tttgactgaa tagataaaat gtacaatgat taatcatcat atggatgtaa ggagagaaat 272881 agatgaaaaa acaacgaatg ctcgtacttt ttaccgcact attgtttgtt tttaccggat 272941 gttcacattc tcctgaaaca aaagaatccc cgaaagaaaa agctcagaca caaaaagtct 273001 cttcggcttc tgcctctgaa aaaaaggatc tgccaaacat tagaatttta gcgacaggag 273061 gcacgatagc tggtgccgat caatcgaaaa cctcaacaac tgaatataaa gcaggtgttg 273121 tcggcgttga atcactgatc gaggcagttc cagaaatgaa ggacattgca aacgtcagcg 273181 gcgagcagat tgttaacgtc ggcagcacaa atattgataa taaaatattg ctgaagctgg 273241 cgaaacgcat caaccacttg ctcgcttcag atgatgtaga cggaatcgtc gtgactcatg 273301 gaacagatac attggaggaa accgcttatt ttttgaatct taccgtgaaa agtgataaac 273361 cggttgttat tgtcggttcg atgagacctt ccacagccat cagcgctgat gggccttcta 273421 acctgtacaa tgcagtgaaa gtggcaggtg cccctgaggc aaaagggaaa gggacgcttg 273481 ttgttcttaa cgaccggatt gcctcagccc gatatgtcac caaaacaaac acaactacaa 273541 cagatacatt taaatcagaa gaaatgggct tcgtcggaac aattgcagat gatatctatt 273601 ttaataatga gattacccgt aagcatacga aggacacgga tttctcggtt tctaatcttg 273661 atgagctgcc gcaggttgac attatctatg gataccaaaa tgacggaagc tacctgtttg 273721 acgctgctgt aaaagccgga gcaaagggga ttgtatttgc cggttctggg aacgggtctt 273781 tatctgatgc agccgaaaaa ggggcggaca gcgcagtcaa aaaaggcgtt acagtggtgc 273841 gctctacccg cacgggaaat ggtgtcgtca caccaaacca agactatgcg gaaaaggact 273901 tgctggcatc gaactcttta aacccccaaa aagcacggat gttgctgatg cttgcgctta 273961 ccaaaacaaa tgatcctcaa aaaatccaag cttatttcaa tgagtattga agaaaagaag 274021 gcgaataagc cttctttttt ttggcttttt aggaccaata atgacctctg aatcttaaaa 274081 tttctttaaa aataagccaa aattaccctt tacttaatta atttggtaac gtaatataat 274141 tggagaattt gttacaaaaa aaggaggata ttatgaaatt tgtaaaaaga aggatcattg 274201 cacttgtaac aattttgatg ctgtctgtta catcgctgtt tgcgttgcag ccgtcagcaa 274261 aagccgctga acacaatcca gtcgttatgg ttcacggtat tggaggggca tcattcaatt 274321 ttgcgggaat taagagctat ctcgtatctc agggctggtc gcgggacaag ctgtatgcag 274381 ttgatttttg ggacaagaca ggcacaaatt ataacaatgg accggtatta tcacgatttg 274441 tgcaaaaggt tttagatgaa acgggtgcga aaaaagtgga tattgtcgct cacagcatgg 274501 ggggcgcgaa cacactttac tacataaaaa atctggacgg cggaaataaa gttgcaaacg 274561 tcgtgacgct tggcggcgcg aaccgtttga cgacaggcaa ggcgcttccg ggaacagatc 274621 caaatcaaaa gattttatac acatccattt acagcagtgc cgatatgatt gtcatgaatt 274681 acttatcaag attagatggt gctagaaacg ttcaaatcca tggcgttgga cacatcggcc 274741 ttctgtacag cagccaagtc aacagcctga ttaaagaagg gctgaacggc gggggccaga 274801 atacgaatta atgaaaaaca aaaccttgaa gaatgctatt cttcaaggtt attctgcttt 274861 cagcacaatg gttttcgcag ccatatcatg aacggtttgt tttttcttcg taaatgcggc 274921 agtcaaatag atcaggcggg agaacacatg cacccacgct atcaggtaac ggacaatggc 274981 ttgcgggaag gatatttttt tatatgtttc gtccctcacg atttgcagcc cgatgatttt 275041 tttgcccagt gtgcccttcc aatttgtcag cggcatcagc aaagggtaca caatcagcat 275101 caatatggcg acaataatga caccggcgga cccatcgcca aacgtaaatc cggctgccaa 275161 aatcactgct gcggcaatga ttacatcaag taaaagagcg caggcgcgca gcatgaaacc 275221 agctagttcc aatagaaaca ctccttaaaa tgttaaataa acacctaatg attgtaaaaa 275281 agaagggcct aaagtgggaa taggtgataa gccttaaatc acaaaagttg gtgaaaatgt 275341 cataggtaaa ttggcataat cagccagctt atcacattac caaattcttt tttagcccga 275401 aaccaagccc tcagaagtta tttttgttaa aatagaaaag ttacaacaga attcggaggg 275461 tttattgtgg gaaaagtgaa acgaaatgcc ccttgcccat gcggcagcgg caagaaatat 275521 aaaaaatgct gcggaagtaa agttgtcgac ttcccggcgg aactagcggc aaaagaagcg 275581 aaacaaattc aggaagactt agtggagtat gccttcacag tacatagaga aagcatttca 275641 ggctttatca accagcatga ttttctttct gctatggaca gacagacgaa agacatcagc 275701 gtatttaact taggaatctg gggaatcttc ttccacccgc ttgctggtga gaagacaatc 275761 ttcgaagagt accttcagaa aaaaggcgat tcgatcactc gtccgaaaac gcgtgagatc 275821 gtagaatcat ggcagagcat gacgcctgct ttattgctgc tgaaggacct gaaggaaggc 275881 atcattcact ttgaagatgt cattacggca aaacaattcg aagtggaaat ggacgccagc 275941 aatcaagacc ttcctccagt gggaagcctg attcttggat acccaatcca cgaagcggaa 276001 aaagcagaat tcttcatgca gttcacgatc ttcccggtga agagaacaga agcgctgatc 276061 agcaaggtga agaaatatgc ggatgccgct gtgaaggacg gcaaaacgcc ggaggacttc 276121 atgaagcagg aattcaacaa cgttctgttc gcgttgttag ctgagaaaga tgaagagcca 276181 caagcagaga aagcggaagt aagcactgtt gagtgggcaa acgacttgga gaaagaaacc 276241 gctgcggcta ttgaagaagg catgagcggg gaagagtatc cgactgaatt gatcccagct 276301 gttattgaca tctggaaaac attctgcgag aaaaaatcac ctgtcatcag aaagccggaa 276361 gcttttgcgg cggcagttga atattatgta aacgcaattt ctcttaacgg cgcgtccgtt 276421 tcccaggcta aactggcgaa aaaatacggc gttagcgcat caacgatttc cagccgttac 276481 aaagaaattg aaagcacgct gcaagatgaa gcagatcgtt ttgcacaagc gttatcctca 276541 taatggaaaa aaccttgaaa agccaggctt ttcaaggttt ttttatttct gaaacggaat 276601 tttgatttct aaccggaaga tggggtggcg gtaggtaaaa tccagcctgc caaaagcgcc 276661 cttcaccagt ttttgaatga tatatgtgcc catgccttca tgagcgccgt ttttcgttga 276721 gcggccaaac gattgataaa ttgtatcgag cacttttggg tccatcccgg gagtgctgtt 276781 ttcacaagtc agtacataaa gcccgctgcg cagtgaagtc tccagtttaa tctctgcttt 276841 ttctcgggcc tccgccgcgc tgtcgagcgc attttctaat atgttgccga ccaagctgac 276901 ctgatcagca ggcgaaaacg gaagggaaga aagcggtgta tgcatatgca gcgaaacact 276961 cacattcgag gcgcgggctt tttctaaaaa atcataaagc acccctgcaa cgtacgcgtt 277021 ctctcctttc aaaaaacggt catattggct gtattgatcc gcccagtttt gaatatatgc 277081 ttgtgtatct gccttgggct gagctgattt gattgcagtg atatgtttca ttgtgtcatg 277141 attccggctt ctgacatcaa tcagcatttg attggcgtgc tgttcagctt gagtcagctt 277201 atcaatttga tcagaaagcc ttgcctgcaa agcagactgt ccgatacgga gcccttcaca 277261 ccctgcaaat atcgcgatta cacataatac cggcatgatg tctgtgccaa tcaacaccac 277321 tcccaccgac atcacttgaa tcaccgcaat ccacgcacaa agccctgagg aacagtgttt 277381 ccacacccgc ttcgtattcc aaatgtacaa tcctgcagca gctgcgccta aagcagcggc 277441 gagccaagag gcggctgtgc tgtgtgaaaa agcagcagct ccctgataac atatgaaact 277501 aaataaaatc agataaagac attgaaaaag ggtaatcacg tactaaactc ctcaaaaata 277561 gtagttttga aaataatcaa gctgctgctt agtgatcatc gcttttttag acgttccctc 277621 aaaggaaact gtgaatgaat gcttggtata agcggaaaaa tgctttatgt aatgaatgtt 277681 gataataaag gaacgatgcg aacgaagaaa atctttttcg ggcaggtcgc ctttaatatc 277741 atttaatgtt tgatacgttt gcacctcttc ggcggttgtc acaatcgtcg tcgaacgtcc 277801 cgtccgttct gcgaaaataa tatccttctt ttgcaggacg tgcatttcag acttttgctt 277861 tatcaatata cgcccattca aactcgtttc cgttttcttt ttcaagtacc ggtcgaagga 277921 agcggccaga cggtcggcat agtacggctt cataatataa tcatggacgt tcaggtcaaa 277981 ggcgtgaacc gcataaccgc cgtggccggt aacaaaaatc acatccacat caagtgaatg 278041 ggatttgatc aaatcagcaa gctcgtagcc agacatatgg ggcatctcga tatcggcaag 278101 cagcagatca atgtctccgt tctttacccg cctgtaggct tccttcgctg aatcggtgga 278161 aaagacaatt tcgacgtcct gcattctgga cacgatcgct tctaacttct ctaaatctac 278221 tcgataatca tctacaagtc cgacttttac cattatcatt cccctagtta catagaatca 278281 tctttattct atcccatttc acgacataaa aagaactctt cgcgacaact ttatccaact 278341 aatccagctt ttcgtatata gtcattacta gaaataaaga taagggagat tgtgacatga 278401 ttacactgac cgattgcagc cgcaggtttc aggataagaa aaaagtagtc aaagcggtgc 278461 gagatgtaag cttaacaatt gaaaaaggag aagtcgtcgg cattctcgga gaaaacggtg 278521 ccggcaaaac gacgatgctg agaatgattg cttccttgct tgaaccatca cagggtgtaa 278581 tcacagtaga cggctttgac acggtcaagc agccggctga ggtcaaacaa agaatcggtg 278641 tcttattcgg aggagaaacc gggctttacg acaggatgac cgctaaagaa aatctccaat 278701 acttcggcag gctgtatggg ctgaaccgcc acgagatcaa agcaagaata gaagatttat 278761 cgaaacggtt cggcatgcgc gattatatga accggagagt gggcgggttt tcgaaaggca 278821 tgaggcagaa agtcgccatt gccagagcgc tgattcacga tccggacatc attttatttg 278881 atgagccgac aactgggctt gatattacgt caagcaacat cttccgcgaa tttatacagc 278941 agctgaaaag agaacaaaaa acgattcttt tctccagcca cattatggag gaagtgcagg 279001 cgctctgtga cagtgtcatc atgattcaca gcggagaggt gatttaccga ggggcgcttg 279061 aatcactata cgagagcgag cgcagtgagg atttgaatta catctttatg tctaagcttg 279121 tcagggggat ttcttaaatg ctgagccata tttataaaaa agaaatgatc gacgctttac 279181 gcgacagaaa aacgatatta ctcacaatct tagtgccgat gattatgatg cttggacttg 279241 tcttttttta tgaaagcatg ctgtccgaca aaggggagca gtacacgctg gctgtcggcc 279301 attcgcttcc gcccgcactg gaaagcaagc ttaatgagat tgacgaaatc agcgtaaaaa 279361 catttgcaaa gcctgaagag gcagttgatg aaggaaaagc agatgcctat ctgaacgtcc 279421 cgaaagagtt cgactcatat gtcaacagca tgacaccttt taaggttgat gtttacggca 279481 attcaatcga tcaagggtcg tcaaatgcca tgcagcttgt gcagtctgcc ttagatcagt 279541 acaaaaatga aattgtgcag caacgtttaa caaataagca tattgatcaa tcggtgatcc 279601 agccgtttac aattcagcaa aaggaagcgg atgaggagaa agggacttcc gctattatgc 279661 tttccgccat tctgcccatg ctgattctga cttccattgt ttccggcgca atgccgatcg 279721 ctcttgatat catggccggt gaaaaggacc gaaagtcaat cgaggcgctg ctattaacgc 279781 cagtcagcag aaacaaagtg ctggtcggca agtggcttgc ggtttccact tttggcgtgg 279841 cttcaggtgt atttgctttg gtgtttttga ttttgtccac cgtgttattt accgaaaatt 279901 taaaaacggc cttccagctg ggagatcata tgtggagtgt aatcggcgct tcagccttaa 279961 tcattgtgct ctctgcattg ctgatatctg cgatggagct tttcatcagc atcatgtcca 280021 gctcggtaaa agaagcgcaa agttatatgt ctctcgtcgt ctttctgcct gtgttcccga 280081 tgtttttcat cttcagcaag gcaccgaacc aatttgactt atcatacttt ctcatcccgt 280141 ttctgaacct gcatgcgtta tttaaacagc ttttattcgg gatggttgac ccggctacca 280201 ttttgtctac gtcaggaacc atcgccgtgc tcatcgccat cttcttttta ctagccagag 280261 cctgcttcct gaaagacaaa tgggttcttc caaaataaac ttgcgaaagg agaaatacac 280321 tttctccttt ttgtatatcc tgaaaaaaga aggaaaatag aaaaaggata tctaatacaa 280381 aaagtgaccc tgcactattt ttcatcaaaa ttggtttcaa aggagaagga acaatggatc 280441 aaacacgtac actcggcaaa acgaagctga aggtgaagcg gatcggattc ggcgcgaatg 280501 cggtcggcgg gcataatcta tttccaaatc taaatgatga aacagggaag gatttagtgc 280561 gcacggcatt ggatggcggc gtcaatttta tcgataccgc ctttatatat ggattggggc 280621 gatctgaaga attaatcggc gaagtcgtac aggaacgcgg cgtgcggaat gagctcatca 280681 tcgccaccaa aggagctcat aaagaagtgg acggcagcat tgaattagac aatagccggg 280741 agtttcttcg cagcgaggtg gagaagagcc tgaagcggct gaaaacagat tacattgatt 280801 tgtattatgt tcactttccg gatggaaaaa cacctctcgc tgaagtggcg ggcactttga 280861 aagagctgaa ggatgagggg aaaatcaaag cgatcggcgc ttcgaacctc gattatcagc 280921 aattgcagga ttttaatgct gacggctatt tggaggtctt ccaggccgaa tattctctca 280981 tacagcgtga tgccgagaaa gagcttcttc catactgtga aaaacaaggc atctccttta 281041 ttccttactt tccgcttgcg tccggactgc tgacaggaaa attcacgcaa gacacagtct 281101 ttgatgattt cagaaaggat aaacctcaat ttcagggtga aacgtttatc cacaatctca 281161 aaaaagtaga taagctgaaa gcagtagcgg aggaaaaaca agcggatacg gcacatgtcg 281221 ccttggcgtg gctgttaacg agaccggcga ttgatgccat tattccagga gctaaacgac 281281 cggagcaatt acaggataac ctgaaaacct tgaacattga actgaccgaa gatgaagtga 281341 atttcatcag cgacattttc aaataaaaaa ggaaatagcc gtcatggcta tttccttttg 281401 gtgttttatt ctttgatgaa tgcttcgact aattctgctg ctctgtaatc atccatatca 281461 agctgccatt ggtcgatgtc atttttcttc attttcactt caactgtttt ttcagatgaa 281521 gcaggtccaa gctttttgaa ttcctcagga tagacttgaa gcgcgtattt cactgcctct 281581 tcatagctgg cactagagtt tttactgtag tagtctttca ctttgtcttc gatgcggtct 281641 gaaagagaag atgcatctac aggtttaact gtggcttcaa caattgcttc gtctttagag 281701 attgaagtcg tttttgcttg aatggaagag tttttgctta atccctcttt aatgccgttc 281761 acgatattat caagcgcttt gctgtccgca tatgtgctgg aaaggccgga agctgagaga 281821 taaccgtctt tggctgattc attaaaatca tttacaattt catttttgtt agcgccggtg 281881 attttttcga aatcggcgtt atctttgccg aaaagaagga catcaacata agctgataac 281941 gcttttgcag aatcttggag cttatctgcc gtcgccagga tttttttgtc ttttccgtca 282001 attttaaaag taactgattt tggcttttta tcaccgtaag attccggcgt atagttaagc 282061 tcgtattgct tgcctttatc tacaacgaag aaaagatttc cttcaacgga tttgtcagcg 282121 ttaatcgtgc tgccctgaag cttttcgcta tagtcttcag ggtctgtgtc agacattttg 282181 gtatcacctt gatacaatgt gaaatccata ctgtctacat tcagcgggtc ttttcctgtg 282241 tttttcaccg cgacattgac ttttaacaca agctggtcat ctgaagtgga cttatcatat 282301 ttagacggaa gtgtgtaaga gacatccttg attttgactt gagctatatc tgagcttttt 282361 tctgtttctg attctttctt ctccgcgctt gttttgctgc cggaacaagc agctgtaaac 282421 atcatcagca gaagaattag gaaaacagcg tacgtttttt tctgaaacat tcatttttcc 282481 tcctcaaatg gtttaggaaa ggggagtctt ttgtctttga gaaatggatc tttttgaatg 282541 gattagcatc atataaccaa aaaaatcagt tcttttctca cggttttcac cggattttct 282601 ggaaactccg ccctcctttg tcatgaatgg acctataaaa agttacaacg gaattaattt 282661 taagattatt agcttttata ttgaataggt tcatcatcct atttttggtg aaaaatgttc 282721 tggtaaaact ggtaaactca gaaaactgtg tattttagac tattactttt tgattagttg 282781 gagggaactt aagaaggatg aaaggggccg cctttgtgaa gaaagaggga ctgaaacaaa 282841 aagcactgga aatcggccgg gtgccgacac acttaaaact ggaaattgaa gattatggcg 282901 gtgatgataa aagagctcat ttttgttggg cagatcctca ggatgagaat accggcatta 282961 tcgtggagct tggaccggac ggagagctgg aatccctttc ccgtgatatt gagcctgaaa 283021 gcggagaaag gctgtctgag gagaaactag aggatatcat gcgccaattt gtcgagactc 283081 atcatccggg ggcactctct gcctttgttc gtgaagaaaa tgaccgtgca tacggcgata 283141 aagtgagatt ttcatatgtt caaatggagg ctgggcttcc tctccccatg agcggattta 283201 tggctgatgt ttccttatca ggtgagattg tttacttccg ttattacggc gaagcgggca 283261 gcatcatcaa gccaaagcgg gtcgcggatg ttgaagaggc acttgccttt atcaagaagg 283321 acgtggagtt cgaccttttg tttgaggttc tccatcgttc tgtttacaaa aacggagatg 283381 atcagccgca tttggtgtac gagcctgaag gtagggcgat taccgtacct gcggatttgg 283441 ttcaagaaga acaagcagtt gatgatgacg atgattacag ggagccggag agctttcctc 283501 tccctttatt cgagggcatc cgcgaaaagg ccgatcctga cagcatgatt ggtattgaaa 283561 atgggtttgt caaagagcgg gaagcggatt tgggagatgg gagaattgga atcgtttggc 283621 ggaatccgga tgaccctgtg tatcagccgg cggataaaag catggacagc tggtttaagg 283681 gacggactca tcaagtgctg aaaaccatct ataacaaaga aaccggaaaa ctcgaaggcg 283741 tcatgtcatt tatggagaaa aaagggccgc tgacagtaac cttggcagag tgtgaaaaaa 283801 tcgcgcttcg ctttctattt gctttatttc cgaatgccga tcaatatttt aggatcagat 283861 acgacgaaaa agatgaagaa gaaaacgcag tcgctggttt tacgtttgaa gcgcattgtc 283921 acggagttcc gctccgattt gggcagatca gaatttgtgt cagccgccag acagggtata 283981 tcaccgttta tatgggaccg gatattgacc caaataagct ggcaaccatt gatcctgtgc 284041 cggctatttc agttgaacaa gccaagtcta tcttttggca gcattttaaa gttgagcttg 284101 gctgggaaag agagtacggg gatgatgaag aacacagcta ccggctcgtc tataagccgg 284161 tgtatccgca ttttatcgat gcacatacag gggagcctgt cttcagcata tggtgaaaca 284221 gccaaaagtc acgcaattgc ctcagatata gaagagagta tgtgatgaaa gtaacagaaa 284281 gaatctcaaa aaacaatgac aataatagaa aaggaccttt cttcacttta aatgaagaaa 284341 ggtcttttta tataataaac aggattctct ttgtcgtaga ctctttgaaa gggatgactt 284401 cattggttaa taaacagctg aaaaagaagg cgcaggagat cggaaatgta ccgacgcatt 284461 atgagcttga gatagaagat tacgaccaaa agcaaaagaa gtacgggcag gcatatttta 284521 tctggaagga ccctaaagat ccggaaaagc acattacagt tgaacttaga aatgacggcg 284581 ccttgctcac cttttcaaca actgtccact ccgagacaga caaaaaactt ccagatgccg 284641 agctgaagct gacggctctt cagtttgccg ctgccaatca tcccggcaca tttatgaatt 284701 ttcattttca aggcaaggaa gaaagggggc agcacatccg gtttgtctat accaaaatgg 284761 agctggggct tccgattccc aattcaggct ttttaattga tatgacacga agcggtcaga 284821 ttgtccactt tctatattac ggggaagggc ataaagccga agttccgacg gaatttgtag 284881 caaaagagaa ggttgtatcc cattacttaa acacaatgtc ttttgagctg atgtacgatg 284941 tcattgatgg cgaacaggaa ccaaggcttg tatatgaacc gattctaccg ggatacagct 285001 atcccgcaga tgtagacgaa attgtgcccg accagcatat cgcagatgaa agaatagaaa 285061 acacggcgcc actgccgccg cttcagaaca aggaagaagt tgatatattt gccttgctgg 285121 gttttacctc tgatatgcag aaagtcagtg aaagagactt tggagaacaa attggaagca 285181 cgtggcgcag gggcgctgcg ccggagcgta aggatttaag cataggaagc tattttgaaa 285241 cgagaaataa aaatacaatc aaaatgaaga cggataaaag aaccggaaaa ttaaaagcag 285301 cgctttcttt tatggactgg cggaacaacc tccaatgctc cacggaagaa tgccaagaga 285361 tagcgcttca atttttgtat gccctctatc cgagagcggc tgagtttttc agggtgaatc 285421 ccgtccgaat tgatgaaaga gggagagtcc gcaaccattt ttctgtctgg tataaaggag 285481 tgccgctgcg gttcggcgct gcccgcatca ttgtcaatcc ggaaactggg ttgattgacg 285541 cttttatggc gcctgatatt gaacctgaac aattggaagc gataaatcac aggccggatg 285601 tttccgctga agaagcgaaa gaagcatttt tagccgcttt tgatgtgaaa ctggaatggc 285661 agcctgattt tacagcaggc agtgaccagc actgcaaact tgtctataag ccggtttacc 285721 cttcctatat tgatgcgcac ataaggaaaa agaaaaggct gtgaggggtg tctagttagg 285781 aatcatctcc aagtgggggt agtccttgaa tcgtttccaa tccccgcccc attcgaaacc 285841 gagtgtctta gcgatctcga caacctccag ccaatctgat tttccgtttt gattgccgtc 285901 atattccata tcccatatga tgctgccatc ctttttttga agggcgaaat caatcgctaa 285961 accatagtta tgatacgatt cccctcctct tgcataggtg acaatattcc ctttttttgt 286021 acgtccctgt ttatataatt catcttgttc cttaaaggac ctgaatcctt cagtaatgac 286081 gacgtcaatg cctttattcg ctgcagcggc tttgagtgca tcggcattct gcttcacaat 286141 cggatgaaga tccgagggga caggcatgtc ctgcaaggcg ttttgagaat gccattcatg 286201 ccgaatataa ctaaaacaaa gatctagaag aaatagaata cataagataa caaatgtttt 286261 tgcgggtaag ttcatatcgg tctcactttc tcaagatgtg ctgaatgtta acgcttttaa 286321 gtgattgact ctctctaaaa gcgaacagct atgataaaat ataacataaa tagtagcagg 286381 aggaaggagg cagaccgatg agagcaaaga ttccatcaga agaagtagca gtaaagctga 286441 atgaatggta caagctcatt cgcgcatttg aagcagatca agcagaagcg ttaaagcagg 286501 agattgaata tgatttagaa gatatggaag agaatcagga cttgctttta tatttttctt 286561 tgatggaatt ccggcatcga atcatgcttg ataagctgat gccggtgaaa gacagcgata 286621 ccaagcctcc gttctctgat atgctgaacg aaattgaaag caatcagcaa aaactcacgg 286681 gcttactgga atactacttt tattatttca gaggaatgta cgaattcaag cagaaaaatt 286741 tcatattagc gattgaccat tataaacatg ccgaggaaaa gctcgagtat gtcgaggatg 286801 agatcgaaaa agctgagttt ctttttaaag tcgcagaagt gtattatcac atcaaacaaa 286861 cgtatttttc catgaattat gcgagccagg cgcttgatat ctatacgaaa tatgaactgt 286921 acggtcgccg ccgggttcag tgtgaattta tcatcgccgg aaatttgacc gatgtgtatc 286981 atcatgaaaa agcactgacc cacttgtgca gcgctttaga acatgccagg cagcttgaag 287041 aagcgtacat gatcgctgct gcctattata atgtcggaca ctgtaagtac agtctgggtg 287101 attacaaaga agcggagggc tatttcaaaa cagccgccgc catttttgag gagcacaact 287161 ttcagcaagc tgttcaagct gtattttcac tgacccatat ctactgtaaa gagggaaaat 287221 acgacaaggc agtagaggct tatgaccgcg ggataaagag cgcggctgaa tgggaggatg 287281 acatgtactt gacgaaattc cgcctcattc atgagctgta tcttggaagc ggcgacctga 287341 acgtgcttac agaatgcttt gacctgctgg aatccaggca gcttcttgct gacgccgaag 287401 atctgctgca tgatacagcg gaacgtttca atcagttgga acattacgag tccgccgctt 287461 tcttttaccg caggctgatg aatattaaaa agaagcttgc cgagcagcgt tttcaatagg 287521 aaatggcaga gaactacagg ttctctgctt tttttgtgct gttttcaact cggaaaaaca 287581 gggtattttc cactgcatag tgagaaacag aggaggatat caagtatgta caaagattta 287641 accggaaaaa cagcgattgt gacagggtct tcaaaaggaa tcgggaaagc cattgcggaa 287701 cggttcggaa aggagaaaat gaatgttgtt gtaaattacc acagcgaccc gtctggagca 287761 gatgaaactc tggaaatcat taagcagaac ggagggaaag ccgtctcagt tgaggcggac 287821 gtgtcaaaag aagaggggat tcaggcgctc ttggacacag ctttagagca tttcggcacg 287881 ctcgatgtga tggtaaacaa ctccggtttt aacggcgttg aggcgatgcc gcatgagatg 287941 agtcttgaag attggcagag agtgattgat gtcaatgtta ccggaacctt tctgggagcg 288001 aaagcagcac ttaaccacat gatgaaaaac aatatcaagg gcaatgtgct gaatatctca 288061 agtgttcatc agcagattcc gcgccctgta aacgttcagt attccacatc caaaggcggc 288121 atcaagatga tgacggaaac gctggcgctc aattatgcgg ataagggaat ccgcgtcaat 288181 gcgatagcgc ccggcaccat tgccacagaa tcaaatgttg atacgaaaaa ggaagagagc 288241 aggcaaaaac aattgaaaaa aatcccgatg aaagccttcg gaaagcctga agaagtggcg 288301 gcagcagcag cttggctcgt atctgaggaa gcaagctatg tgaccggcgc aacacttttc 288361 gtcgacggcg gaatgacact ttatccatct cagcttgaat agaagacaaa acagggggat 288421 tgcgggatga aaacagactg gtggaaggat gcagtggtgt accaaattta cccgagaagc 288481 tttcaggaca gcaatggaga cggaattggg gacttgcggg ggattatttc ccgtcttgac 288541 tacataaagg agctcggggc agatgtgatt tggatttgcc cgatctatcc ttctccgaat 288601 gttgattacg gctatgatgt gacaaaccat aaggcgatta tggattctta cggaacaatg 288661 gacgattttc acgagctgct ggaccaggtg catcagcggg gattaaagct ggtgatggac 288721 tttgtgttaa atcacacctc ggtcgagcat ccgtggttta aagaagcgga gctggacaaa 288781 aacagcaaat accgtagcta ttattattgg cgtcccggca caaagaacgg cccgccgacg 288841 gactggctct caaactatgg atgcccggtc tggcaatacg aagagcacac cggagaatac 288901 tatctccata tgaatgccgt caaacaagct gatttaaact gggaaaatcc cgaagttcgc 288961 caggcggtgt atgacatgat gaaattttgg ctcgataaag gggtcgacgg tttgcgaatt 289021 gatcagctcc atctcatttc taagaaagaa tatcttcctt cgtatgagga ctatatcaat 289081 cagcaggcag agccgaagcc ctttcagcca aatggcgaac gaatccatga ctatttaaaa 289141 gaaatcacag atgaagtgtt ttctcattat gatgtcatgt ctgtcggaga ggtcggcagt 289201 gtcacaccgg aagaaggcct gaaatatacg ggaacagata agcatgagct gaatatgatt 289261 tttcactttc agcatatgga gcttgatcag cagcccggaa aagaacattg ggatttgaag 289321 ccccttgagc tttctgattt aaaatcggtt ttgacaaaat ggcaaaagaa gcttgaacat 289381 caaggctgga atacattgtt ttggtgcaac cacgaccagc cccggattgt gtccagattc 289441 ggagacgatg gggaataccg caaagcatca gcgaaaatgc tggcagccgt aatttatttt 289501 atgaagggca cgccgtatat ttatcaggga gaagaaatcg ggatgacaaa cgcgccgttc 289561 acccggattg aagactacaa agatatccaa acgatcaata tgtatcataa acgggtgttt 289621 gaaaaaggct atgatccaaa tgatgtgatg agatcgatct tagccaaaag ccgggatcac 289681 gcccggaccc cgatgcagtg gaacagcggc aaaaatgccg gatttactga cggcacgcct 289741 tggctgaagg tcaatccgaa cttcaccgca atcaatgtgg aggaagcgca gggagatcct 289801 gattctgtct taaactatta caaaaagctg atcagcctga gaaagcagta cgctgacctc 289861 atgaaaggga gctttgatct tttgcttccg gacgatccgc agttgtttgt atacatgaga 289921 gaaaacagta aacaacagct tttgtcggtc aataattttt caaaagagca ggctgttttt 289981 cagtggccta agaactgcgg caaagctcag gcctcactgc ttctcagcaa ttataacaac 290041 gatgatcttg atgacgaaat ggtgttccgg ccttatgaga gcagggtcta tcttctggac 290101 aaaacaaact aatgattgaa gtagcccggc atttttagcc gggttttttt agtacatata 290161 ttcgctctgc aggcgggaag aataaatgaa aatgaaattt attcttgcaa aacgtaatga 290221 cttcggttta ttatgatata ggattacaaa atcgttatca ttttgattta aagttactga 290281 aaaagagggg atatacgata tgtttaaaaa atggagcggt ttgtttgtga ttgcagcgtg 290341 ctttttatta gttgcagcat gcggcaactc atcaacaaaa gggtcggcgg attcaaaggg 290401 tgataaactg cacgttgtca caacgttcta cccgatgtat gaattcacaa aacaaattgt 290461 aaaagacaaa ggcgatgtgg atctgttaat cccatcttcc gttgaaccgc atgattggga 290521 accgacgccg aaagacattg ccaacattca ggatgctgat ttgttcgttt ataatagtga 290581 atacatggag acatgggttc cgtcagctga aaaaagcatg ggccaaggcc atgccgtttt 290641 cgttaatgca agcaaaggca ttgatttaat ggaaggctct gaagaagaac acgaagagca 290701 tgatcatggg gagcatgagc acagtcatgc aatggaccct cacgtatggc ttagccctgt 290761 tctggcacag aaggaagtta aaaatattac ggctcaaatc gtgaagcagg acccggataa 290821 caaagaatac tatgagaaaa atagtaaaga atatattgca aaactgcagg atcttgataa 290881 actatatcgt acaaccgcaa aaaaagcgga gaaaaaagaa tttatcacgc agcatacagc 290941 ttttggctat ctggcaaaag aatacggctt gaagcaggtt ccgattgcag ggctttcacc 291001 tgaccaagaa ccgagcgcag ccagcttggc aaagctgaaa acatatgcca aagaacataa 291061 tgtaaaagtt atttactttg aagaaattgc atcctcaaag gtcgcagata cgctcgccag 291121 tgaaatcggc gcgaagacag aagtgctgaa tacactggaa ggcttgagca aagaagaaca 291181 ggataaaggt ttagggtata tcgacattat gaaacaaaac ctcgatgccc tgaaagattc 291241 actattggtt aaatcataag atagtgtgcg ccggaggggt gcacactatt tctttgtgag 291301 aaaggaagat taacatgaat ctcgtctcat tgaaagatat cgttttcggc tattcccata 291361 cgcctgtttt agataaagta tcacttgata ttgaaagcgg tgagttcgtc ggcatcactg 291421 gaccaaacgg cgcctctaaa tcgacgctca taaaggtaat gctcggcatg ctgaaaccgt 291481 gggaaggcac agtgacgatc agtaaaagga atacagaagg gaaacgcctg accatagggt 291541 acgtcccgca gcaaatttct tcatttaatg ccggatttcc gagcacggtg ctggagcttg 291601 ttcagtcagg ccgctataca aaagggaaat ggtttaaacg tttaaatgaa gaagatcatc 291661 ttgaagtaga aaaagcattg aaaatggtgg aaatgtggga cctccgccat cgtaaaatcg 291721 gtgatttatc aggcggacag aaacagaaaa tctgtatcgc cagaatgctc gccagcaacc 291781 cggatctgct gatgctggac gaaccgacga cagctgttga ttacgacagc agaaaaggat 291841 tttacgaatt tatgcatcat ctcgtgaaaa atcacaaccg cacagttgtg atggttactc 291901 acgaacaaaa cgaagtacag caatttttag ataaagtgat tcgattagag agaggagaaa 291961 aaggcggatg gaaatgtttg acttggaatt catgcgacga gcttttctag caggcggcat 292021 gatcgccgtc atggctccga tactaggagt gtatctcgtt ctcagaagac aggccttaat 292081 ggctgacaca ctttcacata tctcattgtc aggtgttgcc atcggctttt ttctcagcac 292141 caatataacc gcagcaagca tagtcgtcgt gaccatcggc gcgatcggaa ttgaatacat 292201 gcggcgggcg tatcggactt attcagaagt gtccattgcc atcttaatgg cagctggttt 292261 gtccttcgcg atgtttttaa tcagcctttc caaaggcaca gccaatatga gcatcgatca 292321 atacctattt ggatcgcttg tgacagtaaa ccagcagcag gtctatatta tcagtattat 292381 cacactgctg atcctgcttt attttattgt actgagaagg ccgctctacc tgctgacgtt 292441 tgatgaagct acagccaaaa catcgggaat caatacaaac gttctctcgt tgtcattcag 292501 tattgtcaca ggccttgcga tttcagtcat tattccgatc atcggggtcc ttcttgtatc 292561 ggccctgctc gtattgccgg cagccttcgc catcagaatt gcaaaaggct ttaacatggt 292621 tttcattaca gccatactca tttcattatt cagcgtattt acgggactga catcatccta 292681 tcagctcggg acgccgccag gtccgtctat taccctgcta ttgatcgttt tgctattaat 292741 cggatttgca gttcagggag tttggacgtt tatcaaaaaa gaagctcagc gcaaaaaaag 292801 aagccgataa catgaaaagc agttttccct agggaaaact gcttttttta tagaaacaat 292861 tcggcaaggc gctcataaga ttcttttttc gcctcaaaat caaacacatt gcacagaacc 292921 atgatttcat ttgtttcgta gcagcctgtg aggtctaaca gctgttgttt gacagtggtg 292981 ggagaaccga tcaccatccg ctttctgttt tcttctatga gttttttatc ggacgctgta 293041 tagggatgag ctttcgcttc ctcgatgctt ggcacgcggc tgtccaagcc ttttccgacg 293101 cgaagaagcc acagatcctg gcttaatgcg agttcttctg cctcttcatc tgtttttgcg 293161 caaatgacaa aaatcgtaaa cagtgcggat ggattcgaaa aatgggctga gggccgaaag 293221 ctttcccggt agatgcggaa tgcattttct cctcgctcgg gattaatgaa atgcccaaat 293281 acatatccaa tcccctggtg cgccgcgcgt cttgcgctgt tttcaccaag accgagcacc 293341 catagctcgg gtgccgtacc aataaggggc gccgctttga ttccggcata cggatggtcg 293401 ggaggaaggg aatctgttag aaaataagag acatcctgca gctgtctgtt aaattcggtt 293461 aagctttttt tcaccccgtc cgttaatgca agtctggttt ttgtcgtgcc gccgggggag 293521 cgaccgacgc cgaggtcaat ccggtttgga tacagggcct caagctggcg aaaggtttca 293581 gccactttaa atgggctgta ttggggcaga agcacgccgc ctgatccgac acgaatggtg 293641 tttgtctgtg ctgcgatgcg ggcgatcatg atttcaggcg ctgtgcttgc cagtcctttc 293701 gtgctgtgat gctcggcaaa ccaataacgc ttatagcccc actgttcgct taattgggca 293761 agctcaaccg aatgctggag agttgtcaca gggctttctc ctttagaaac aggtgcctga 293821 tcaagtatgc ttaaatgaat caaaaggccg cttcctttct gtctgttttt agatggtgac 293881 accagaatag gcaaaatgac ttgcccgcgt caaatggttt gtttaagaag cgcactttat 293941 agcatttgca aatcatatat caaatatgga agtttttttt cgaggttttt cgtcaattat 294001 tcttaacttt tacgaaactt tgatataata acaaacgtat atattagtaa tttacggctt 294061 attttccttg tgagcgtaaa aataaatgtg actatcttca cattttgatg agtaggagtg 294121 aatcgtgtgg caatttcttt agaaaaaggt caacgaattg atttaacaaa aggaaaagcc 294181 ggtctgtcaa aattgatggt cggtctcggc tgggacccag tgtcctcagg cggaggattc 294241 ttcagcaaac tgcttggcgg aggcggtccg aatatcgact gtgacgcttc agtgctgatg 294301 ctggaaaacg gaaaattcac cgataagaaa aacctgattt atttcggcaa cctgaaaagc 294361 cgctgcggcg gtgtacagca tacaggcgac aacctgacgg gtgacggtgc gggcgatgac 294421 gagcaaatta tgatagattt agataaagtg cctggaaaca tcgataagct tgtatttgta 294481 gtgaacattt acgattgtgt cagaagaaaa caagatttcg gcatgattca aaatgcgttt 294541 atccgcgtag ttgatcaatc taatcacgag gaaatgctca agtacaattt gagagacaat 294601 tacgccggca gaacaagcct gattacagca gaaatctacc gcagcggcag tgagtggaag 294661 tttgcggcgg tcggtgaagg cacaaacgat acgagattag aagatattat cagtcgatac 294721 gtataaaaga aaaggagtgg atgaaacatg acaatttcat tggcaaaagg acaaaaagta 294781 gatttaacaa aaacaaatcc gggtctttca aaggttgttg tcggtttagg ctgggatacg 294841 aacaagtatg acggcgggca cgactttgat cttgactcaa gtgtgtttct gttagacgcc 294901 gcgggcaaat gcgcgtcacc aaacgacttt attttctaca accagcttga aggcggcaac 294961 ggttcagtcg ttcattcagg cgacaacctg actggtgctg gcgaaggcga cgatgagaat 295021 gtaaaagtaa atctcagcgc tgtaccggca aacattgata aaatctcatt tgttattacc 295081 attcacgatg cagaagcgcg cagccaaaac tttggacaag tatcaaacgc gtttgtccgc 295141 atcgtaaatg aagaaacaaa tgaagagctc atccgttacg atcttgcaga agatttctct 295201 attgaaacgg caatcattgc aggggagctt tacagacata acggcgagtg gaaattctca 295261 gcaatcggct caggctacca aggcggcctt gcccgcattg caacagacta cggtttgcaa 295321 gtcggttaag acaaatacga agagcagaaa ggagagaggc agtatggcca ttcaattatc 295381 aaaaggacag cgcattgatt taacaaaaac aaatccggga ctgactaaag cggtgatcgg 295441 cttaggctgg gatacaaaca agtactccgg cggacacgat tttgacctgg atgcttcggc 295501 ctttttagtt gatgcgcatg ataactgcgt aaatgatctc gatttcgtct tctataataa 295561 ccttgaacat ccgagcggcg gtgtcatcca tacgggtgac aaccgcacgg gtgagggcga 295621 cggagatgat gagcagatta tcgttgattt ctcaaaaatc cctgctcaca ttgagaaaat 295681 cggcatcaca gtgaccattc acgacgctga agcacgcagc caaaactttg gacaagtttc 295741 caatgcattt gtccgcgttg tggatgaaga aacgcagaat gagcttcttc gcttcgattt 295801 gggagaagac ttctccattg aaacagctgt tgtcgtttgt gagctttaca gacacggcgg 295861 cgagtggaaa ttcaatgcaa tcggcagcgg attttccggc gggctggctg cattgtgccg 295921 gaattacggt ttgcaagtgt aagcgagtga caaatagaga agtcaccgtt tcaaattata 295981 ggaggaaaaa acttggactt tttacatcat attttgtcta cgtatgcttc atttttcgat 296041 tggaaaatgt ggggggaagt tctgactgat cctgtttcct ggggtttgat cggttccctt 296101 gttgttctgg aaggcctttt atcggccgat aacgcgcttg ttcttgcggt catggttaaa 296161 cacctgccgg aaaaacagcg gaaaaaagcg ttaacgtatg gtttgtttgg agcttatatt 296221 ttcaggttta ttttcatcgg gctcggtatg cttctcatta aattctggtg gatcaaggtg 296281 cttggcgcgc tttacctggc ttggctcgtc attaagcact tctggatagg cgaaaaagaa 296341 gaggaagcgg acggcatgaa gaaaaactct tggatggtcc gcacgttcgg gatcttctgg 296401 gcgactgtca tttcagtaga attaatggat cttgccttct ctgtggacag catcctggcc 296461 gcgtttgcag tatctgaaaa agtatgggtg cttctgattg gcggtatgct tggtatttta 296521 atgatgcgta cagtggcaaa agtgttcctt gtgctgattg ataaaattcc tgagctggaa 296581 aacacagcat tcgtcttaat cggcattatc gcgctgaaaa tggcggggag cgctttccat 296641 tacgaaatgc cgcactctgt attcttcatt atcattatcg ctgcatttgc ggtaacattg 296701 atcattcact acatcaataa acaaaagcag gtgcgcgaac aaacagccgc ttcaaaagaa 296761 gaataaaaca aaacaaggag ggaggttcaa tgtccttcct tttttgttac cgaaatatcg 296821 tttcaatgac aaaccggaaa ggaggatatg atgagacaag aagaactaac cattcataaa 296881 gcacttccgg ctgatggcga ttggaaaagc ctgctgtttc agccattgcc ggagcgggat 296941 cactatgaaa ctgcacaagg cctttctttt tctcgtcttg ccggtcagat attgggcacg 297001 cctattgatg agacggacta ctataacgag ctgtatgagc tgtctgtaaa cgaccgcata 297061 acgattttga gtgaaacgct tgataaaaca atcgaaccgg aaacatttca aaagcttcag 297121 catattcatt ccatcaatca gaaagaaaaa gggctgtcag tcagccgctt tgttgccttt 297181 ctggacgggg aaaagctgat tgcgaagcac tcaaatccct tgatgcaccg ccatttaaga 297241 aaagcgttga tgacgctttt acataccttt gcggacagtc atgaaaaggg gctgaatcat 297301 cctgattttc gcagagtgct gcttgatgtc tcgaagtttt ccttaaacca tctgaaccct 297361 tggctggaaa aaaccgatat agagcgggag atgccgaagg ttgtttggta tggagatgcg 297421 acgaaaagcc agctctattt cttatattat ctgatgctgg tcggctgtga tgtactgctg 297481 ttccatccgg cgggaacgga tcagctggcg cttgtcgacc cgaagcagga gctcggtttt 297541 acggaaaagc tcccggatgt ttcggagctt cagccgtttc cgaaagaaaa accagaccgg 297601 aaatcaacag tggcttaccg ctcaacaaag gaaattgaac atgtgctgaa tcacgaggaa 297661 tccatgctat ataagccgtg gcagttcaga gatcacacac cggtgtccgt tacgctgaaa 297721 acgacctatg atgaattgtt tttaatcacg aaagaacgcg cctttattcg gccgaatttc 297781 aaagctgata aacattccat tgagattccg aatgtattcg ccaaaattat gggcgtgtcg 297841 aaagacaata aggaatattg gaacaggctt catactctag cggattatca ggaaacagaa 297901 atggtcagaa gctttccatt tacagaagaa ataaagtcga actatcaatt tcactacagc 297961 cacgcacttg atcaagaagg gaacattgat ccggacaagc tgatggcaag caatgtgtgg 298021 cagtacaaac agctgccggc gggcgttcag actgccattg ccaaaacgat ttcgagaatg 298081 tgcaggtacc cgcggcttaa agccttgcat caggaacaag tcaaggatgt tcaaatctat 298141 ttgtttaaac aaacaacaaa cctgcctgct aatctgctga aattgattca aatgttcgac 298201 tatgcgcaaa ccgttccgaa actcgtttta tatcatacgg aaatgagcgg cggactcacg 298261 cgttcggatg ctgccgccct gctgttcctg aatgaaatcg gaatcgatat catcatttat 298321 aatccgcccg gacaccaaga tattgagcag tttattgaag aggatcagta tgatatccac 298381 tggctggatg acatggtgtt tcagcaggac tacaaagagc cttcgcttgt gaaaaggctc 298441 ttcagaacca ttacccaaaa ataaggagag aagaaaagca tgacaacaga aaatcaaaat 298501 ccgcttgttc tcgataaaaa tgaagagatt tcccagcaaa aagctgacga tatccgtctt 298561 cagctccgtc aggaaccaga agtgaagcgg cttgctcaac aaattgacgt caaaaaccaa 298621 atggagctgc ttgagtacgg caaggagccg gccgttgaaa tatccaagtt ctctgaccgc 298681 atcttgggga tgatgaaaac aacaagcgtg acagactccg gcacaatgct gactcagctt 298741 gggaaaatca tggaccgctt cgacaaaaat gattttgatg agccaaaggg attaatggcg 298801 aaaattttca aacgcggcgg cagcatgatt gaaaaaatct ttaaaaagta tcagacgctt 298861 ggcggagaga ttgaaaaaat ccacgttgag atttcaaaat acaaagatga gatgacgaag 298921 acgaactaca cgctcgatga aatgtatgaa aacaatatca aatactatat ggagcttgaa 298981 aaatacgtcg ttgccgggca gatgaaactg gaagagatgc agtcgatcct tccttcatat 299041 gaggaaaaag cggcaagcgg gaaccagctg gcgcaaatgc agctcgatac gttgcgcaac 299101 ggcattcagg cgcttgagga acgggtgtat gatcttgaca tggcacggat ggtggcgctt 299161 caaaccgcac ctcaaatccg tctcctgcag cgaggaaatg caaagctgat cgggaaaatc 299221 aactccgcgt ttatcattac cattccgatt ttcaaaaacg gcattattca ggctgttacg 299281 gtaaagcggc aaaagcttgt ggctgattcc atgagcgagc ttgaccgccg gacaaacgag 299341 atgctgaaac gaaatgctga aaacatctcg agccaaagtg ttgaaattgc gagaatggcc 299401 ggcagaccga gcatagatat tgaaacgatt gaatcgtctt ggaacacgat tgtcagcggc 299461 atgcaggaaa caaaacaaat cgaagaagaa aacaagcgcc tccgcgaaga cggcgcgaga 299521 cgaattgccc agcttcagga taatattaaa aaagcagcat tgcagcaata ataaaaaccc 299581 cgcttgtgga acataagcgg ggtatttcaa ttacatcatt tagttaatga caatgtgtaa 299641 agacaggtgt aaacttaaac ggtaatcatt ttgcatatca gaggtgttgg caatgggaaa 299701 acaacagcct atatcccagc gtaaactgct gggcgtcgcc ggtttggggt ggctgtttga 299761 tgcaatggat gtcggaatat tatcgtttat tatcgccgcg ctccatgtag agtggaatct 299821 gtcgcccgaa gaaatgaaat ggatcggaag cgtcaattcc atcggcatgg ctgcgggtgc 299881 gtttttgttt ggtttgcttg ctgatcgaat cggccgcaaa aaagtgttca tcatcaccct 299941 tttatgcttt tccatcggaa gcggcatttc cgcttttgtg acgagcttat cggcatttct 300001 aatccttcgt ttcgtgattg gtatgggact tggcggcgag cttccagtcg cttcaacact 300061 cgtttcggaa gcggttgtgc ctgaaaagcg gggcagagtg attgtgcttt tggaaagctt 300121 ttgggccgtg ggctggctcg cagcggcctt gatttcttac tttgtgatac caagcttcgg 300181 ctggcaggct gcccttctgt taactgcgct gactgctttt tatgcgctgt acctgcggac 300241 gagtctacct gattcgccga aatatgaatc gctttctgcc aaaaagaggt cgatgtggga 300301 gaatgtaaaa agcgtctggg caagacagta tatacggccg acggtgatgc tgtcgatcgt 300361 ttggttctgt gtggtgtttt cttattacgg catgttccta tggctcccga gtgtcatgct 300421 gctgaaaggc ttcagcatga ttcaaagctt tgaatatgtc ctgctgatga cgcttgctca 300481 gctacctggc tatttctctg ccgcatggct gattgaaaaa gcgggccgga agtggatact 300541 cgtcgtttac ttgattggca cagcaggaag cgcctatttc ttcggaacgg cggattcctt 300601 aagtcttctg cttacggctg gagtgctgtt atcgtttttc aatctcggtg cgtggggcgt 300661 gctgtatgct tataccccgg agcaataccc gactgcgatt cgagcaacag gttcaggaac 300721 gacagcagcg tttggaagaa tcggcggcat cttcgggcct ttgctcgtcg gaaccctggc 300781 agcccgtcat atttcgtttt cggtcatctt ttcaatcttt tgcattgcaa tcttacttgc 300841 ggttgcttgt attttgatta tggggaaaga aacgaaacaa actgagctag aataggaaaa 300901 gcacctctta aaagaggtgc tttcagcgtg tcgacaaacc ctcgcattcg ttgtcaggac 300961 tgcgcttcgg tgctcaatgc gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa 301021 acgccgtcgt catcacatcc tgtgaatgtc cgctcctatg ctcgtccttc ctagacttca 301081 agggttttca atcacgctga aaagattttg tcaacaatct gaggcacctc ttgaatgagg 301141 tgctttttta caattgcgcc cgggctgtgg attggcgttt cccggtttta ctgattgtct 301201 ggtagagcgt catagaaagt atgaacagaa tggcagtaaa tcctgtgaca gctccgaaat 301261 gctgtgtgct ttgatataaa aaacctgcaa tacttgtacc gacagtggtt ccggcataca 301321 tagcggcatt ggaaagggaa gcgatggttc ctcgcgcatt tggtgcaatg gattgaaaga 301381 cacccatcat taacggaaag atgatgccag ctgtaaagaa cgtgagaaaa aagccggctt 301441 ctactaaaaa caagtttgga aagaacggaa gagcgaaata gagagcgccc attagcagca 301501 tcccgctgat cagtgtttta aacatgccca gcttttctga aacccggctg ccgataaggc 301561 tcccgagcat atttcccagt ccgagtacaa gcatagctgc gccaatttgt gacacggtta 301621 aatgataatc cgcggaaagc caagtaccca gaaagctgaa cgatgcgaag tttccggttt 301681 gaaacagaaa ataggcaagc agaatgaccg atgttttcgg caatgaaaaa agctcccgat 301741 aggggttgac aattgatggg cgcgccaatg gttcagaagg ccggatgcca ggcatgaccg 301801 ccgccaggat caatagaaga ataagcgagc acgctgacaa aacgaaaaat ggcgtatgcc 301861 atgtaaagga agcgagaaac cctccaatag gaagtccgag catttgtgaa gcggccaaac 301921 ctgctgtcgc aatccccatg ccttttatga tctgagaagg ctggacaatg actgggatgg 301981 acgcccaaat ttgaggcgtc acaaacgcag cgctaacgcc tgcggcaaaa cggaacaggc 302041 acatggcggc aaaagaggga gcgatgccgc ataaaaatgt ggatacgata aagcctgcaa 302101 gtccccacag catgactgtt ttcctgttca gccggtctga gattgggcct gcaatgaaag 302161 cgaagagtgc ataaccgagt gcataagcac tgaccatcca gcctgacaaa tcagtagaga 302221 catgaaactg atcctgtaaa agggggagaa gcggcgaaag caaaaaggta tccgtgccaa 302281 tgacaaacat gacactgaag aaaagccaaa tgcgattcaa attttatcac tcctattgtt 302341 ttataacttt aaaactatga aacagatatg tatagagaaa accctttgtt agagggtttc 302401 caaaaagcca ggcaggtatg tttgaaatgt gtcttcacgc agactgacgt attttgtccg 302461 cgaatctttc cgggttgccg tcaatcccgc ttcacgcagc gttttaaaat gataagatgc 302521 cgtggttttg acaatattgc acttttcacc tacttcaccg cagctgagtt cttttccgct 302581 gacataaagc gtacgaataa tggcaagcct tgattcatca gacagtgctt taaaaatttg 302641 cgctctgatt tgatcatctg attgtttcat agtcatgaaa ctataataca taatgggtgt 302701 tgaaaaagca acttattttt ccagtaaagg agcaggaagt cataagagga aggaggaatt 302761 caattccaat aaaagcgttt tcaactaaag gtaggagaaa aatcacccgt aaaatacaat 302821 catataggag gattacagag catttagaag cataaataag atcatgtggt cacatggatg 302881 tttataaaga aatggtacag aataaaagag aatatgctgt ttgtgtggga agttacataa 302941 atgttacggt aataaagatt gcttaatatg gagggaaaat atgagtgtag atgagaaacc 303001 aattaagata aaagtcgaga aagtctctaa gatttttggg aaacaaacaa agaaggcagt 303061 tcaaatgctt gccaacggaa agacaaaaaa agagatcctg aaagcaaccg gatcaaccgt 303121 tggggttaat caggcagatt ttgaagtata tgatggtgag atatttgtca tcatgggtct 303181 atcagggagc ggtaaatcaa ctttagtacg gatgttaaac cggcttattg aaccgactgc 303241 cggaaatatt tacattgatg gtgacatgat aacaaatatg tcaaaagacc agctccggga 303301 agtccgccgg aaaaaaatca gcatggtctt ccaaaagttc gctctgtttc cgcacagaac 303361 gatacttgaa aacacagaat acggactgga gcttcaaggt gtagacaaac aagagcggca 303421 gcaaaaagcg cttgagtctc ttaagctcgt tggactggaa ggatttgaac accaatatcc 303481 cgaccagctt tccggcggga tgcagcagcg tgtcggcctt gcccgcgcgt tgacgaatga 303541 cccggacatc cttctgatgg acgaagcgtt cagtgcgctc gatccactga ttcgtaaaga 303601 tatgcaggat gagcttcttg atcttcacga taatgtcgga aaaacaatta tctttattac 303661 gcatgacttg gacgaagcgt tgcggatcgg cgacagaatt gtcctaatga aggacggcaa 303721 catcgttcaa atcggcacgc ctgaagaaat cctgatgaat ccatctaacg aatatgttga 303781 gaaattcgtc gaagatgttg atttgtctaa agtcctcaca gcaggccaca ttatgaaacg 303841 cgctgaaaca gtgcggattg ataaagggcc tcgcgtagca ttgacactga tgaaaaacct 303901 tggaatttct tcaatttatg cagtggataa acaaaagaaa ttattaggtg ttatctatgc 303961 gtctgatgcg aaaaaagcgg ctgagtctga tttgtcactt caagacatct tgaatacaga 304021 atttacgact gtaccagaga atacgtatct gactgagatt tttgacgttg tgtccgatgc 304081 gaatattcca attgcggttg tggatgagaa gcaaagaatg aaaggaattg tcgtaagagg 304141 cgcgctgatt ggcgcacttg ccggcaataa cgagtatatc aatgctgaag gcactaacga 304201 acaaacacaa gatccttctg cacaggaggt gaaataagat ggatagactg cctagaatac 304261 ctttagcaga tattattgac cgttttgttg actggattac gatgacgttt ggcggattct 304321 tcgacggaat cgctaacgga ttggccgctt ttgtaaatgg aattgtcacc ggtcttggat 304381 ttattccatc tattttgtta acgattattt tcgccgcact tgcgtggtgg atcagtacaa 304441 ggggaattgc gttatttacg ttgattggat tcctcctgat cgattattta ggatattggg 304501 acccaatgct gcaaacattg gcgcttgttt tgacatctgt gattatttcg attgtggtcg 304561 gggttccgat cggaatttgg gcgtctcaga aagaaacggt tcgccgtatt gtaacgccaa 304621 ttcttgattt aatgcagaca atgcctgctt tcgtatatct attgccggcg attttcttct 304681 ttaacatcgg tgttgtgccg ggtgttgttg catctgttat cttcgcgatg ccgccgacaa 304741 tccgcatgac tgttctcggt attaaacaag tgccggcgga tttgattgaa gcgactgagg 304801 cattcggttc tacaacagct cagcgtttgt ttaaagttca gctcccgctt gcgacaaaaa 304861 cgattttggc cgggatcaac cagagcatca tgcttgcgtt atcaatggtt gttatcgccg 304921 caatggtcgg tgcaccggga cttggttctg aagtatacag tgccgttaca cagctgaaaa 304981 ccggggtcgg agtagaggcc ggtatcgcca tcgttatcgt tgccattacc ctggaccgta 305041 ttactcaaaa tattaaagtg aagaagaaaa gcagggggaa tgcctgatgc ttaaaaaaat 305101 cataggcatc ggcgtttccg ccatgctggc gctctcactt gcggcttgcg gttcagaaaa 305161 cgatgaaaat gcatccgcag cagaacaagt gaataagacc atcatcggga ttgaccccgg 305221 ttcagggatt atgtccctga ctgacaaagc gatgaaggat tatgacctga atgactggac 305281 attgatttca gcgtcaagtg ctgcgatgac cgctacgctt aaaaagtcat acgaccgtaa 305341 gaaaccgatt atcattacag gatggacacc gcactggatg ttctccagat ataagctgaa 305401 atatctcgat gatccgaaac aatcttatgg cagcgcagag gaaatccata cgatcacacg 305461 caaaggcttc agcaaagagc agccgaatgc cgcaaagctt ctgagccagt ttaaatggac 305521 gcaggacgaa atgggcgaaa tcatgatcaa ggtggaagaa ggcgagaaac ctgccaaagt 305581 tgctgctgag tacgtcaata aacacaagga tcagattgcc gaatggacaa aaggcgttca 305641 aaaggtgaag ggagacaaaa tcaaccttgc ctatgtggcg tgggacagtg agattgcaag 305701 tacaaacgtc ataggcaaag tcttagaaga cttgggctat gaggtaacac ttactcaggt 305761 agaggctggg ccgatgtgga ctgcaattgc gacgggaagt gcggatgcat ccctttccgc 305821 atggctgccg aatacccata aagcatacgc cgctaaatat aaaggcaaat atgatgatat 305881 tggcaccagt atgactggtg tgaagatggg gcttgttgtt cctcaatata tgaaaaatgt 305941 caactcaatt gaagatttga agaagtaatc aaaaaagcag cctgtgtcag gctgcttttt 306001 ttgcgttaag aagcgttagc ggcagcaagt gattccgcct tctgaaatgt tttgagcacg 306061 gcgttcgcca aaatatgaat gccggtaaac atcgcatttc tgtcaaaggt catgtgcgga 306121 tgatggagcc ccggctggag cccgcagcct agtccgagca tcgttgtttt cagattcggc 306181 accttcacgg cgtaaaaatg gaaatcctcg ccgccggtgg tgacaagcgg gtcatcaagc 306241 cgctcagccc cgatgatttc cgtaatggct tctgccatga tcgcttcagc ttctttattt 306301 tgtgttgccg caggaaggct gtgttctttg tgcagctcga tctttgcgcc aaatgcagcg 306361 gcggccgctt cacaggctct ttctgtttcg gcgattaatg cctccatggc ttcattggtc 306421 tgtgcgcgca aatcaaggct gaacgatgct tttcctggaa tgatgttaga gctttcaccg 306481 ccggcttgca gttttgtcat tttgacggta tgcgggattt gcgggtcaat atgaatgagt 306541 ccgagcttgt gtacaagaaa tgccgcaatt tcaatgctgt ttttcccgag gtgcggacgg 306601 gcgccatgag cctcttcccc gatgatcgtt ccctcaatgt gctggcttga tccgtgcaga 306661 atagaaggag cgcagcggcc gttctgtgtt tcctggatcg gacggacgtg aacgccatac 306721 aaatagtcga tatcatcaag cacgccttct tctatcattt tcaaggcgcc gccgcctttt 306781 tcttctgccg gctgaaagat aaaacggatt gtgcccttcg gaagctcagg ttgttttttt 306841 agcagcatta acgtgcccaa tgccattgtc atatgtgaat cgtgtccgca ggaatggttg 306901 gcgcgaaatg tgccgttaac ctcctgccac agcgcgtcaa tatcagcgcg taccgctaca 306961 acaggtgagc ctgagccgat ttcgccgaca accccggtgc agtctgaaaa cgtgcgcgtc 307021 cggcacccta aatcctcaag cttttgtttc aaaaatgaag ttgtctcata ttccttccag 307081 ctgacttcag ggttcgcgtg cagatgctcg aagatgtcca taatggtttg tttcatttct 307141 tctgaaagct tttgcatggt aagaaatacc tccttctatc agaatgaatt tttaccttct 307201 ttactttatt tatattgaaa caggaagata ggctgtatat aatatagcac atattgctac 307261 tattcagaat aattaatatt ttcaaacaga ggggatggat cgaaatatga gtatgccagc 307321 agccgaaaca cagcctaaga aaaaacgtat gacatttaaa atgcctgacg cctatgtcct 307381 cttatttatg attgctttca tttgcgcaat cgcttcatat attgtgccgg caggtgaatt 307441 tgaccgcgtg acaaaggggg atgtcacgac cgctgttccg ggaagctatc attcaattga 307501 acagtctccg gtcagattga tcagcttttt tacttctcta caggatggaa tggttggatc 307561 agcacccatc atctttctga ttttattcac aggcggcacc attgctattc tagaaaaaac 307621 gggtgccatc aatggcctga tttacaatgt catcagcaaa ttccgcacaa agcaattatt 307681 atttatttgt attgtcggcg cattgttctc cattctcgga acaaccggga ttgtcgtgaa 307741 ttcagttatc ggttttatcc ccatcggcct cattgtggca cgatccttaa aatgggacgc 307801 agtcgcggga gccgctgtta tatacatcgg ctgctacgct ggatttaact ccaccatatt 307861 atcaccgtca ccgctcggtt tatcacaatc aatcgcggag ctccctcttt tctcaggaat 307921 cggcctgcga gttgtgatat acatatgctt tttgctgtct tctattattt atatctattt 307981 gtatacgaga aaattaaaaa aatcaaaaga tgccagtgtg ttaggaacag attggttccc 308041 tgcggcagga atgggcgaag ccggtaaaga agaagatcag tcagtgccgt ttaccgttcg 308101 ccataagctg attttggctg tggcgggact ctcacttgtc ggatttttat acggcgcttt 308161 gaagcttggc tggtcagatt cccaaatggc tgcgacattt atttttattt ctgtccttgc 308221 cggtttaata ggcgggcttg cggcgaacga tattgccaaa accttcatta cgggctgcca 308281 aagtcttgta tacggggcgc tgattgtcgg gatggcacga agcatttccg ttatccttga 308341 aaatggaaag cttctcgata ctgtcgtcaa tgctttggct tcacttttgg atggattcag 308401 cccgattgct ggggcaatcg gcatgtatat cgccagtgcg ctgcttcatt ttctcatctc 308461 ttcaggttct ggcgaagccg ttgtatttat tccaatcctg gcgccgctcg ctgatttgat 308521 gggaatcacg agacaggttg cggttgaagc ggttatgctt ggagaagggg tcgtcaactg 308581 tgtgaacccg acatccggcg ttctcatggc ggtgcttgcc gccagcggta ttccgtatgt 308641 caagtggctg cggtttatgg tgccgcttgc tctgatttgg ttcttgatcg ggcttgtctt 308701 tatcgtgatc ggagtcatga tcaattgggg gccgttttaa cgattgctgc ccgccggctt 308761 gtacggcggg cttttgagtt attcattgca gaagcgcagg ctgttattgt aacatgtaag 308821 ccataagcca ttcgtaaaag tgcgggagga aggtcatgaa taatctgcgt aatagacttt 308881 caggcgtgaa tgggaaaaat aagagagtaa aagaaaaaga acaaaaaatc tggtcggaga 308941 ttgggatgat agcgggagca tttgcgctgc ttgatgtgat catccgcggc attatgtttg 309001 aatttccgtt taaagaatgg gctgcaagcc ttgtgttttt gttcatcatt atcttatatt 309061 actgcatcag ggctgcggca tccggaatgc tcatgccgag aatagacacc aaagaagaac 309121 tgcaaaaacg ggtgaagcag cagcgaatag aatcaattgc ggtcgccttt gcggtagtgg 309181 tgcttacgat gtacgacagg gggattcccc atacattctt cgcttggctg aaaatgattc 309241 ttctttttat cgtctgcggc ggcgttctgt ttctgcttcg gtatgtgatt gtgaagctgg 309301 cttacagaag agcggtaaaa gaagaaataa aaaagaaatc atcttttttg tttggaaagc 309361 gagggaagcg ttcacagttt cgggcagctt tttttatagg aacattgatt tgtattcact 309421 ctgccaagtt gttttgatag agtgattgtg ataattttaa atgtaagcgt taacaaaatt 309481 ctccagtctt cacatcggtt tgaaaggagg aagcggaaga atgaagtaag agggattttt 309541 gactccgaag taagtcttca aaaaatcaaa taaggagtgt caagaatgtt tgcaaaacga 309601 ttcaaaacct ctttactgcc gttattcgct ggatttttat tgctgtttca tttggttctg 309661 gcaggaccgg cggctgcgag tgctgaaacg gcgaacaaat cgaatgagct tacagcaccg 309721 tcgatcaaaa gcggaaccat tcttcatgca tggaattggt cgttcaatac gttaaaacac 309781 aatatgaagg atattcatga tgcaggatat acagccattc agacatctcc gattaaccaa 309841 gtaaaggaag ggaatcaagg agataaaagc atgtcgaact ggtactggct gtatcagccg 309901 acatcgtatc aaattggcaa ccgttactta ggtactgaac aagaatttaa agaaatgtgt 309961 gcagccgctg aagaatatgg cataaaggtc attgttgacg cggtcatcaa tcataccacc 310021 agtgattatg ccgcgatttc caatgaggtt aagagtattc caaactggac acatggaaac 310081 acacaaatta aaaactggtc tgatcgatgg gatgtcacgc agaattcatt gctcgggctg 310141 tatgactgga atacacaaaa tacacaagta cagtcctatc tgaaacggtt cttagacagg 310201 gcattgaatg acggggcaga cggttttcga tttgatgccg ccaaacatat agagcttcca 310261 gatgatggca gttacggcag tcaattttgg ccgaatatca caaatacatc tgcagagttc 310321 caatacggag aaatcctgca ggatagtgcc tccagagatg ctgcatatgc gaattatatg 310381 gatgtgacag cgtctaacta tgggcattcc ataaggtccg ctttaaagaa tcgtaatctg 310441 ggcgtgtcga atatctccca ctatgcatct gatgtgtctg cggacaagct agtgacatgg 310501 gtagagtcgc atgatacgta tgccaatgat gatgaagagt cgacatggat gagcgatgat 310561 gatatccgtt taggctgggc ggtgatagct tctcgttcag gcagtacgcc tcttttcttt 310621 tccagacctg agggaggcgg aaatggtgtg aggttcccgg ggaaaagcca aataggcgat 310681 cgcgggagtg ctttatttga agatcaggct atcactgcgg tcaatagatt tcacaatgtg 310741 atggctggac agcctgagga actctcgaac ccgaatggaa acaaccagat atttatgaat 310801 cagcgcggct cacatggcgt tgtgctggca aatgcaggtt catcctctgt ctctatcaat 310861 acggcaacaa aattgcctga tggcaggtat gacaataaag ctggagcggg ttcatttcaa 310921 gtgaacgatg gtaaactgac aggcacgatc aatgccaggt ctgtagctgt gctttatcct 310981 gatgatattg caaaagcgcc tcatgttttc cttgagaatt acaaaacagg tgtaacacat 311041 tctttcaatg atcaactgac gattaccttg cgtgcagatg cgaatacaac aaaagccgtt 311101 tatcaaatca ataatggacc agagacggcg tttaaggatg gagatcaatt cacaatcgga 311161 aaaggagatc catttggcaa aacatacacc atcatgttaa aaggaacgaa cagtgatggt 311221 gtaacgagga ccgagaaata cagttttgtt aaaagagatc cagcgtcggc caaaaccatc 311281 ggctatcaaa atccgaatca ttggagccag gtaaatgctt atatctataa acatgatggg 311341 agccgagtaa ttgaattgac cggatcttgg cctggaaaac caatgactaa aaatgcagac 311401 ggaatttaca cgctgacgct gcctgcggac acggatacaa ccaacgcaaa agtgattttt 311461 aataatggca gcgcccaagt gcccggtcag aatcagcctg gctttgatta cgtgctaaat 311521 ggtttatata atgactcggg cttaagcggt tctcttcccc attgagggca aggctagacg 311581 ggacttaccg aaagaaacca tcaatgatgg tttctttttt gttcataaat cagacaaaac 311641 ttttctcttg caaaagtttg tgaagtgttg cacaatataa atgtgaaata cttcacaaac 311701 aaaaagacat caaagagaaa cataccctgg aaggatgatt aatgatgaac aaacatgtaa 311761 ataaagtagc tttaatcgga gcgggttttg ttggaagcag ttatgcattt gcgttaatta 311821 accaaggaat cacagatgag cttgtggtca ttgatgtaaa taaagaaaaa gcaatgggcg 311881 atgtgatgga tttaaaccac ggaaaggcgt ttgcgccaca accggtcaaa acatcttacg 311941 gaacatatga agactgcaag gatgctgata ttgtctgcat ttgcgccgga gcaaaccaaa 312001 aacctggtga gacacgcctt gaattagtag aaaagaactt gaagattttc aaaggcatcg 312061 ttagtgaagt catggcgagc ggatttgacg gcattttctt agtcgcgaca aatccggttg 312121 atatcctgac ttacgcaaca tggaaattca gcggcctgcc aaaagagcgg gtgattggaa 312181 gcggcacaac acttgattct gcgagattcc gtttcatgct gagcgaatac tttggcgcag 312241 cgcctcaaaa cgtacacgcg catattatcg gagagcacgg cgacacagag cttcctgttt 312301 ggagccacgc gaatgtcggc ggtgtgccgg tcagtgaact cgttgagaaa aacgatgcgt 312361 acaaacaaga ggagctggac caaattgtag atgatgtgaa aaacgcagct taccatatca 312421 ttgagaaaaa aggcgcgact tattatgggg ttgcgatgag tcttgctcgc attacaaaag 312481 ccattcttca taatgaaaac agcatattaa ctgtcagcac atatttggac gggcaatacg 312541 gtgcagatga cgtgtacatc ggtgtgccgg ctgtcgtgaa tcgcggaggg atcgcaggta 312601 tcactgagct gaacttaaat gagaaagaaa aagaacagtt ccttcacagc gccggcgtcc 312661 ttaaaaacat tttaaaacct cattttgcag aacaaaaagt caactaaccg caactttaga 312721 gtaaagggct gattgtcaat gtgggagcag ttgtatgatc cgtttggaaa cgagtatgtg 312781 agcgcacttg tggcgctcac tccgattctc ttttttcttt tggctttaac tgttttgaaa 312841 atgaaaggca ttcttgcggc atttcttacc ctagccgtca gtttcttcgt ctccgtttgg 312901 gcatttcata tgccggttga aaaagcgatt tcttctgttt tgttaggaat cgggagcggg 312961 ctgtggccca ttggctacat cgtcctgatg gcggtgtggc tgtataaaat cgccgtgaaa 313021 accgggaaat ttaccattat tcggtccagc attgccggca tttcgcctga ccaacgatta 313081 cagctattat taattggttt ttgttttaac gcgtttttag aaggcgcggc cggttttggt 313141 gttccgattg cgattagtgc ggcgctgctc gtcgaacttg gttttaaacc gttaaaagcg 313201 gcggcgctct gcttgattgc aaacgctgcc tccggagcct ttggggcgat tgggattcct 313261 gtcatcacag gggcgcagat tggtgatttg tctgctcttg agctgtctcg gacattaatg 313321 tggacactgc cgatgatctc atttttaata ccattcctgc ttgtattctt attagaccga 313381 atgaaaggaa tcaaacagac atggcccgct cttctggttg tgagcggtgg gtatacagcg 313441 gttcagacac tgacaatggc ggtgctcggg ccggaattag caaacatttt ggcggcctta 313501 ttcagcatgg gcgggcttgc cctcttcctc cgcaaatggc agccgaaaga gatttaccgc 313561 gaggaagggg ccggcgatgc tggtgagaaa aaggcatacc gtgccgctga cattgcgaaa 313621 gcgtggtctc ctttctacat tttaactgcg gcgatcacca tctggagcct tcctgccttc 313681 aaagcgcttt tccaagaagg cgggctgtta tatcaatcaa cgctcctgtt caaaatgcct 313741 tttctgcatc agcaaattat gaaaatgccg ccgattgcgc catctgccat gccgttagat 313801 gcagtcttta aagttgatct gctgtcagcg actggtacag cgattttagc ggcggtcatc 313861 gtgacagggc tgttcagcaa aaagttctcc tctcgggatg cctttgcttc cttgaaggag 313921 acgggaaaag agctgtgggt gccgattatg acgatctgct tcgtgatggg gtttgccaat 313981 ctggccaact tcgcagggct cagctcttca attgggttag cattggcgaa aacaggagac 314041 ctgttcccgt ttgtcagtcc tgttctcggc tggattggcg tgttcatcac cggttctgtt 314101 gtcagcaata atgctttgtt cggccatttg caggttgtca cgggagcgca gatcggtgcg 314161 ggttcagatt tgctgttagc cgcaaatacg gcgggcggtg tcatggcgaa acttgtttct 314221 cctcaatcta tcgccatcgc tgccgcagcg gtcggccaaa caggcaagga atctaaactg 314281 tttaaaagga cagtggcgta cagcctgatt ctgttattga tcatttgtat atggacgttt 314341 attcttgcaa gattaggagt gtaatagaaa aaagcagtac atgcccagca tgtactgctt 314401 tttttatgtt aatttgcttt ctttgtcatt tcggctgttg ttttcactct ggcttttccc 314461 ataaataaaa tggtaaccgc cgcgaggaca attggaatca aagcgagcaa aaagacatac 314521 gtgatacttg atgacatcgc gtcaataatg cgattcagga tcgcatcagg aatctgggaa 314581 cgtgttcccg cttggaatat ctcctgcggg tcgccaatat tttgcgcagc gcctgatccc 314641 gctgagcctt tcataccgct gaaggcgtca ttcagcttgt ttgtgaatac gtttgtttgc 314701 accgttccga aaatggtgac acctaaggtc atgccaaatg atcgcaaaaa tgaatttgta 314761 gagtttgccg ttccccgaaa gcgaggttca agatcattca tcgatgccgc cggcagcagg 314821 gagaagttaa agcctacacc aaagcctgaa atcatcataa agactgtcag ccatacccgt 314881 gctgtgtcag gcgtcatatt ggaaagaagc agcatgccga taaagaaagc tataacagat 314941 atcagcatca aattgcggaa gcttgccttc gtttggaaga tcccgccgat catgcttccg 315001 atgactgatc caatcatcat cggcgtcaga atgaagcccg cgcttgtcgc cgagctgccg 315061 tagaccgcct gaacgaaaat cggaataaat accgctaaaa taataaatgt tccgccatac 315121 aggaaagcga gaatctgtgc tgtggcaaac aagcggttct taaacatcca gaaagaaata 315181 atcggctctt ctgcttttct ctccacaata aaaaaggcaa tgaagaaaac ggcgaataca 315241 ataaacagcc cgatgatctg aatggagttc caatcgtatg ttttgccgcc aagctcaagg 315301 gcgaacatca ggcatacaat ggatacgact aaggtaatcg cgccgcccca gtctattttc 315361 tgctttctgt gctccagaga ttctttgtag tagcgaataa tgaaaaacaa tgacaatgcg 315421 ccgatcggca cattgatgta aaacacccag tgccagctga tcgaatctgt aatgatcgcg 315481 cctaagagcg gaccaagaac actggataat ccaaatacag caccgaacat gccggacatt 315541 tttccgcgtt tttccggcgg aaacaaatca aagataatgg taaaggcaat cggcaggagc 315601 gcgccgcctc cgatcccttg aatggcccgg aagatgatca gctgattcat cgtctgggca 315661 atcccgcata aagcagaacc gattaagaaa aaaataagtc caaacaggaa aaaacgtttt 315721 cggccgtaca tatcggaaag cttgccgtaa atcggcatgc cagccataac cgccaccata 315781 taggatgccg tcacccaggc aaatttatcg aagcttccaa gatcggctac gatattgccc 315841 atcgcggtgg caacaatcgt attgtccatt gcagacatca agatgcccag caggagaccg 315901 aggaccacaa atttggtgga agcctgtttt gctgttgttg tgtccatttg ttctacctcc 315961 tcttactttt ctatgtaagt tctgatatca tgataatagt ttgattgttg aatatctcga 316021 ttatcaagat aaactcgatt ttatagggag gactgtcagt tgtcaacaag aaattccaga 316081 agtgagttgg aaaagactgc tgttcagctt tttcgaaaac tgggcacaag aacggttctg 316141 tttcatcagg cagccgctca agctctcggt ctgtttccca ccgatttgaa atcagctgac 316201 attttaaatg aagcagggcc gatgacggcc ggagagctgg ggaaaaaaac cggcctcagc 316261 acgggttccg tcacggcgct tgttgaccgg ctggaaaaag cggggtatgt ggctcgtgaa 316321 aaggacccga acgatcgcag gagagtcgta atcgtccctt tgactgcttc gaaaaaacat 316381 ataaaggatt tgttccgtcc tctgtctgag tcaacgatgg atttgtgccg cgaatatacg 316441 gaagaggagc tggaactcat tttcagtttt gtaggcaaag ctgccgatat tatggaggaa 316501 gagcttgaac gtctgaaaca gtaagtgaat ttgtgcatag cttggcccgt tcccgaataa 316561 attgtacaag ttacataaga gaagggagta cgggccggtg aacatttttt tgagctatat 316621 tgtgctggga ctgtccttgt ctgcgcctgt ggggccagtg aatgcggcgc aaatagacaa 316681 aggaattaaa aacggttttt ggcatgcatg gattttcggt ttaggcgcca tgacagcgga 316741 tgggctgtac atgcttttta tctatttcgg gctgtcgcag ttcttgaccg ctccatttgt 316801 gaaaacgttt ttgtggctgt tcggcttttt tgtcctgacc tataccggaa ttgaaacgct 316861 gaaaaacgtc agagaaccga tggatgtgcg aagctcgcgg gggaaaccgt catacaggaa 316921 aacattcgca tcgggttttc tcatttcatt gtcaaaccca ttgagcatcc ttttttggct 316981 tggaatttac ggaagcattc ttgcgaaaac agcagaggcc tacaatatga atcagcttct 317041 aatctatagc tccggcatca tgatcggcat tttaatctgg gatttctgca tggctatcac 317101 agccagtacg ttcagaaacc tgcttcatga aaagctattg agaggattga ccggaatcgc 317161 cggtgtatcc ctccttgtgt ttggctttta ctttggttat cagggcatca aacagttatt 317221 gggctgattc atgaaggaca gtcacctgcc gcttccagtt ttaatatagt atccagatga 317281 tactggaggt ggatcaatgg tgaatgggat ttacaccaaa agttttctgg aacgtattca 317341 ggaagagctt cctgaatggc aaagaatcgc ttttgagctg ctggcagaaa ctctggggga 317401 cgacgcggat acatttccgt gcattcccgg acgccaggcg tttctgactg atcagcttcg 317461 gattgctttt gccggagatc cgcgggaaaa ccgcacagcg gaggaactgg ctccgttgct 317521 tgcggagtac ggcaagatat cgcgggacac gggaaaatac gcatccctcg ttgtgttgtt 317581 tgatacaccg gaagatttgg cggagcatta ttcgattgaa gcgtatgaag agctgttttg 317641 gcgcttttta aatagactga gtcatcaaga cgaaaaagaa tggccggaag acattccggc 317701 cgatcctgag cattataaat gggagttttg ttttgacggc gagccgtatt tcattctgtg 317761 cgctacaccg gggcacgagg caagaagaag ccggagcttt ccttttttta tggtcacgtt 317821 tcagccaagg tgggtgtttg atgacctaaa tggatcaact gcatttggcc gtaacatgag 317881 caggctgatc cgatctcgtt tagaggccta tgatcaggct ccgattcacc cgcaattagg 317941 ctggtacgga ggaaaagata atcgtgaatg gaagcagtat ttcctccgtg atgacgaaaa 318001 acaggtatcg aagtgcccgt tttcttattt aaagaacatg ttcaacaaaa tgaaataaat 318061 caaggactgg cagggcgatc tttatgaccc tgcttttttt gatagatcat ggtaacgatg 318121 gcgataatca cgagaaaacc tatgctgacg aaaaaaccgg gccggcttga tttttcaaac 318181 aatgtaccgg acacagctgc agcaatcaga accatcgcta aataaatttg cgtttttccc 318241 atgccctcgg gatcagtcag ctttttgctg gagaacagga taaacagcca agtgtataaa 318301 agcataagcc ccgcagctgt tgtcatatgc tcataaatgt ttttaggcag cactaacgac 318361 aaaataatgg agaggacaag ccccgcaaac gtcagcccaa gtgccggcca gcatattttt 318421 ttgccttcct ttagagtaaa gcatttcggc gcgtcgccgt catcagccat tgtacaaagc 318481 aatgtcgtaa ccgcaaatag cgaagcgaca agggtcgaga accctgcgat gatgaaaatc 318541 ccgttaaata tatcaaggat gatctcaagg ttatatcctt ttaatgacgt aatgaacgga 318601 ctgtcctgtt cagtaaacgt gtgtaacgga accaaaagca gagcaagccc gattgaaatg 318661 atataaataa tcgccagcgt cgccagcatc agtttccctg atttagacgc ttcctcaggt 318721 ttttttaagt gaaccgccat cagccccatg acctcaattc cgccaaaagc gtaaaacgcg 318781 tagattaaac ctgtccacag ccccatggcg ccgtatggga aaaactcact cgtcttattt 318841 ggaacatgta tgccatgatt tccgccggac aggataccgc ataaagccag gatggcaatg 318901 acaataaaca taaaaatagc agctgtttta atgactgcca gcacgttttc tgttttttca 318961 aagacggaca ggccggtgaa aataataagg agcccaagta ctgcgtagat tgaggcaaac 319021 acccatagcg gcacttgagg aaaccaatgc ttcgtaaaga gcgaaatggc tgtcagctgg 319081 cttccggtaa tcagcatttc tgatgtccag tacacccagc cgttgctgaa gcctgcccat 319141 ttgccgaatg cttttcgggc atacgcacaa aacgagccct tttccggctg cttcgccgat 319201 agcttggcga gctgttcaaa gacaaaatac gtaccgatcc ctgcgatcag aaatgaaagg 319261 agaacggaaa aaccgctttt tacaattgcg atgctggaac cgagaaagaa gcctgttcca 319321 atcgtgcagc cgactccgat cagtgacagc tgccaccaag ccagattccc ttttggctgg 319381 tctttttttg tttggctcat tatttattca acccctttta tctaaggtta gattgtgatc 319441 tgtccaaagc ttatatacat cggatttttg cctcttttta catggagaag gaagcagacg 319501 ctcatactaa tgaaaaaagg agcaaaccaa tgacacagca atatattgtg gagccgaaaa 319561 aagggcttgg gctgaagctg aaaaaggggc agattttaaa ggtggttgat gtagaagggc 319621 agcaggtggc tgattttgtc gcataccatg ccaaggattt ttatgaacac cttgatcagg 319681 gagcgacgat agacgccaat cactccattc atgtgaaggt caacgaccat ctctactcca 319741 acctgtataa gccgatgtta accctgattg aagatacggt cggcaagcat gatctgctgt 319801 tgcccgcctg ccgtcctgat atgaacaggc tcttatatgg gaagcaaaag gatgagtttc 319861 aggatacgtg ctatgacaat atgaaccgtg cgcttgagca gtttggcgta ccgaagcccc 319921 acatgcatta cccatttgcg atttttatga atactgtcct tgatgagaaa gggaatctgt 319981 ctgtggaaac gccgctttcg aatgccggag attatgtaag gctcagggcg gagatggatt 320041 taattgtcgc gttttcttcc tgcccgattg aaaaagggaa atgcaatggc gacagtgtga 320101 catccatacg ggttgaagtc agctgatctc tcttgttcac agtgaatgaa gacctgtgct 320161 atatttaata gggatacata acagtcatga ttcattttca ttgatttagg gaaatgatca 320221 gtaataaggg aaaatgtaca ggaggaatga ttgggatgag catgcaggaa aagattatgc 320281 gtgagttaca tgtgaagccc tcaattgatc caaagcaaga aattgaggac cgagtcaatt 320341 ttttaaaaca atatgtaaag aaaaccggtg ctaaaggctt tgtattggga atcagcgggg 320401 gccaggattc aacacttgcg ggaagactcg ctcagcttgc ggtggagagc attcgcgagg 320461 agggcggaga cgctcaattt atcgcggtcc gtcttccgca tggcacacag caggatgaag 320521 acgatgccca gcttgctttg aagtttatta agccggataa atcatggaag tttgatatta 320581 aatcgacagt cagcgctttt tctgatcagt atcagcagga aacaggcgat cagctgacgg 320641 actttaataa aggaaacgta aaagcaagaa caagaatgat cgcgcaatac gcgatcggcg 320701 gccaggaagg tcttcttgtg ttaggaacag accatgctgc tgaagcagtg actggtttct 320761 ttacgaagta cggtgacggc ggagcagacc tcctgccgct gacaggcttg acgaagcgcc 320821 agggaagaac cttgctgaaa gagctgggtg caccggaacg cttatactta aaagaaccga 320881 ctgccgatct gctcgacgaa aaaccgcagc agtcggatga aacagagctt ggcatttcct 320941 acgacgagat tgacgattat ctcgaaggaa aagaagtatc agcgaaagta tcagaagcgc 321001 tggaaaaacg ctacagcatg actgaacata aacgccaggt tccggcgtct atgtttgatg 321061 actggtggaa ataagttgaa gaaagcccgc tctcggagcg ggcttttgtc gtgtacagaa 321121 gctttatttg atgcggatat gattcagctt taccattaat ctgtcggcga accttcggag 321181 gctgcctctt gtatcaggat ctaatgggag ttcggctctc gcggcaatgt tctctgccac 321241 atcctgaatc gacaggttgt ctgtttgaat gtggtcctca aaaatgggtg atgataatcc 321301 ttcaacacag cggtcaattt gtttggcggc ccatgagttt tttccttctg ctctggtgcg 321361 cagccttttt aacaaggttt cctttgaagc cattagtgta aagtggtgaa cgatcctgcc 321421 ttcctgtctg agcctgccga tgatctcatt gaagtattca gggtgtacaa tcgtcatagg 321481 cacaataagg atgccgcggt atgtatctgt cagagaagct agcaaactgt aattgaacgc 321541 ccgccataaa ggatagcttt gaaaatcgtc ctttgcgatc tcctgcggca ccatggagcg 321601 cagcgcaaaa cccattttct cgggatcata cacgtaagat gggttcagcc ttctgtgcag 321661 ttcgaaggct gtttgtgttt ttcccgaacc gaatgccccg tttatccaaa tgatcatcgc 321721 catttctccc ttcctattta tcatacagaa aaagaccctt ccatcgaaga gtcagctgga 321781 aaaacaataa aggcggaagg ttttaacgct tttttgcgtc gaagtattaa aatacctgca 321841 gaaatgttgt acaatgaatg tcattcaggc aaaaatggct acaacaaagc gcactataag 321901 cttgaccggt aaagccggta tctatataaa tattcgctaa ataagcatat aatgaatata 321961 taatttcatt ccttaggagg atttcgccga agatgaacgc taaacgagcc atcccagtaa 322021 gagaaagaaa tatcgtcctg atcggattca tgggtgtagg aaaaacaaca atcggccaat 322081 tggtcgctaa aaaattatat agagatttta ttgatattga ccagcagatc gaaaaggatt 322141 tcaatatgtc aattcctgag atatttgaga aaaagggaga agactttttc cggaaaacgg 322201 agaaggaata tattttagac atctgccatc ataaacgatt caaaatcgta tctctgggcg 322261 ggggatcttt taaacaagaa gaaatcagaa attgctgtct ggaaaactgt ctcgtgcttc 322321 atctggacct gtcatgggag aactggaagc agcgcgcgga tttattgatc gaaagccgcc 322381 ctgtactgca taaccgttca atggatgaaa tggaacagct gtttaacgaa agaaaagtca 322441 tttatgacaa gcacaattca aaagtggcaa cagacaacct ttccccggaa gaggttgccg 322501 attacattgt tgagacatta aaaattggct gggatcttta tcagccgatg taaaaagccg 322561 tgcgcagcgc acggcttttt ttatcgtttt atcccttgta tcaaaatcgc ttttaaacaa 322621 aaggagatgg gctgtccgtt ttggttcaat gtaatacaga acgtgtcgcg tgcttcgtct 322681 gatgcgtgat tcaagtgggt aatgatttgt ttttctcggt cagcgggggt tccgcctcgt 322741 ttgatccagc tatcgtattg aatcggcaag ttccactttt ggatgtcttg ataggccagt 322801 tgattggcgc tgaacatcgc ctgccattct gataatgagc tttcacgaac atgggaaggg 322861 tctcgaagcc ggttcaaatg attgacaaac tcatcaagaa cgggatcttc aggcgcgtaa 322921 tgatcaacta agagaaaacg tccgtcctgt tttagtacgc gtgcaacctc tctgacagct 322981 ttgcggacat ctgaaaaatg gtgggctgcg tatcggcagg tgatgatgtc aaatgaatcg 323041 tcggggaagg ggagtgactc tgccgttcct tgctgaaagc gtacgttttc aactcctttt 323101 tcttgcgcga aggaggacgc aacctcaacc atctctttcg ttgcatcaac accgatgcac 323161 tcctgtacat aaggagaaaa tgccagcgcc gtatggccgg cgcccgctcc tatatccagc 323221 actcgatgct ctgcccggca ttccgctgtt ttgatcatca accccaaatc ttccccctcg 323281 gcaaatacct tttcatcccg atacatctcg gcgtttttag aaaacggtgt ttcatttgtc 323341 atttgaacca gctccttctt ttcgtaaatg atgatatgga ttatgttagc aatttctgtt 323401 atgattcgtc caagatataa aaatgatgaa aatgataggt tcaacctatg gaggctgaaa 323461 tggatattaa agtgatggaa tatgcagcgg aaattgcccg gcgccaaagc tttacaaagg 323521 cggcggaaca tcttcatatc gcacagccgt ctctcagcca gcaaatcaaa aagcttgagg 323581 ctgagctggg gcttaccctt tttcacagat cccatggctc tgttacactg acacctcacg 323641 gcaggcgttt cattgaaaaa gccgaggaca tcattcgttc cagagatgat ttgcttcggg 323701 aaatgcagga gcgatcacag ggaatcggtc ataaattatc catcgggatt cctgctgtaa 323761 cagggagata tctctttcct ccgctgctga agcagttttt ggcgcgctat cctcatgtgg 323821 aggttcagct tgttgaaaaa gatccggttt cattagagaa gatgacggca aagggagaag 323881 ttgacctttc tgttttatcc ttgcccatcg aggatgaacg gctctccatt acacccttgc 323941 tcacggaacc ggttgttctc gcggtgccga aggaaaaaca aaggtggatg ccgccggaat 324001 tggtcgcgct gattgagaaa gcgctggaag aagatgaggg acgccagccg tgtgtgccga 324061 ttgacatggt aaggaacgtg ccctttattc tgttaaaaga aggcttcggc tttcgcagga 324121 cagttctcga tctctgtgcg gaaagcggct ttaagccgaa tgctgccttt aagacgagcc 324181 atattgaaac cgcccaatct cttgtggcta acggattagg tgtgacaatg gcaccgaata 324241 tggtcagaag ggataaagat ccgggtgtga tctatttatc gattcaatcc gcgccatcac 324301 gaaccctcgt ctttgtcttt ttaaagaacc gctatgtcag tctgacggcc caggccttta 324361 tggaactaag ccgggaaagt cttaaacaaa cgtttgatga aggctgtctg ggaaacaaag 324421 atgaaaatat ttagaaaaca aagacgaaac gtggtagtat aggaatacaa actaaatctt 324481 ataaaacaaa ggggaataat cggaaatgca actattcgat ctgccgctcg accaattgca 324541 aacatataag cctgaaaaaa cagcaccgaa agatttttct gagttttgga aattgtcttt 324601 ggaggaactt gcaaaagtcc aagcagaacc tgatttacag ccggttgact atcctgctga 324661 cggagtaaaa gtgtaccgtc tcacatataa aagcttcgga aacgcccgca ttaccggatg 324721 gtacgcggtg cctgacaagg aaggcccgca tccggcgatc gtgaaatatc atggctacaa 324781 tgcaagctat gatggtgaga ttcatgaaat ggtaaactgg gcactccatg gctacgccac 324841 attcggcatg cttgtccgcg gccagcagag cagcgaggat acgagtattt caccgcacgg 324901 tcacgctttg ggctggatga cgaaaggaat tcttgataaa gatacatact attaccgcgg 324961 tgtttatttg gacgccgtcc gcgcgcttga ggtcatcagc agcttcgacg aggttgacga 325021 aacaaggatc ggtgtgacag gaggaagcca aggcggaggt ttaaccattg ccgcagcagc 325081 gctgtcagac attccaaaag ccgcggttgc cgattatcct tatttaagca acttcgaacg 325141 ggccattgat gtggcgcttg aacagccgta ccttgaaatc aattccttct tcagaagaaa 325201 tggcagcccg gaaacagaag tgcaggcgat gaagacactt tcatatttcg atattatgaa 325261 tctcgctgac cgagtgaagg tgcctgtcct gatgtcaatc ggcctgattg acaaggtcac 325321 gccgccgtcc accgtgtttg ccgcctacaa tcatttggaa acaaagaaag agctgaaggt 325381 gtaccgctac ttcggacatg agtatatccc tgcttttcaa actgaaaaac ttgctttctt 325441 taagcagcat cttaaaggct gataaatgtg aaaagccgcc gcatatcatc aggcggtttt 325501 tttctgcaaa ctgccggaat gagaacagac tggagacgaa tagatatgaa acaaagaatc 325561 attgatgaat taaaacggat cgagcagtca tacggagtca aaatcgtgta tgccgtcgag 325621 tcaggaagcc gcgcatgggg atttccctcg caggatagtg attacgacgt ccgctttatt 325681 tatgttccga aaaaggagtg gtacttttca attgagcagg agcgtgatgt cattgaggaa 325741 ccgattcacg atttgctgga tatcagcggc tgggagctga gaaaaacgct tcggcttttc 325801 aaaaagtcaa accctccgct actcgaatgg ctgtcctcag acattgtgta ttatgaagca 325861 tttacgaccg cagagcagtt aagaaaactc cgcacggagg catttaagcc tgaagcaagc 325921 gtgtatcact atatcaatat ggcgagaagg aacgtcaagg attatctaca aggacaagag 325981 gtcaaaatta aaaagtactt ctacgttctt cggcctattt tggcctgcca atggattgaa 326041 aagcacggaa ccataccgcc aatggacttt actgttttga tgaatgaact tgttgctgaa 326101 cccgagctga aggctgaaat ggaaaccttg cttgaacgga aaagaagagg ggaagagctt 326161 gacctcgaag caagaatcga tgttattcac caattcattg aaacggaaat cgaaagaatc 326221 atggaagcgg caaaagaact gaaggcagag aaaaaagata tgacatctga attgaaccgt 326281 ttgcttttga atacggttga agaagtgtgg aaggatggag gaagctgatg ttttttgtcg 326341 cttccttttc tcctttattc gacagaatcc ccccccgact ttctaactat ctgattgtgg 326401 caaacccaca aaaataatca gaatctttgt attttgagaa tattgtgaac gctggttttg 326461 tccatttaca ataaactcat acaaatactt cttagattgc ggggtgttga ggttggaagt 326521 gatcacaaga gattttttct tatttttatc caaaagcggc tttctcaata aaatggcgag 326581 gaactgggga agtcgggtag cagcgggtaa aattatcggc gggaatgact ttaacagttc 326641 aatcccgacc attcgacagc ttaacagcca aggcttgtca gttactgtcg atcatttagg 326701 cgagtttgtg aacagcgccg aggtcgcacg ggagcgtacg gaagagtgca ttcaaaccat 326761 tgcgaccatc gcggatcagg agctgaactc acacgtttct ttaaaaatga cgtctttagg 326821 tttggatata gatatggatt tggtgtatga aaatatgaca aaaatccttc agacggccga 326881 gaaacataaa atcatggtca ccattgacat ggaggacgaa gtcagatgcc agaaaacgct 326941 tgatattttc aaagatttca gaaagaaata cgagcatgtg agcacagtgc tgcaagccta 327001 tctgtaccgg acggaaaaag acattgacga tttggattct ttaaacccgt tccttcgcct 327061 tgtaaaagga gcttataaag aatcagaaaa agtagctttc ccggagaaaa gcgatgtcga 327121 tgaaaattac aaaaaaatca tccgaaagca gctcttaaac ggtcactata cagcgattgc 327181 cacacatgac gacaaaatga tcgactttac aaagcagctt gccaaggaac atggcattgc 327241 caatgacaag tttgaatttc agatgctgta cggcatgcgg tcgcaaaccc agctcagcct 327301 cgtaaaagaa ggttataaca tgagagtcta cctgccatac ggcgaggatt ggtacggcta 327361 ctttatgaga cgccttgcag aacgtccgtc aaacattgca tttgctttca aaggaatgac 327421 aaagaagtaa aaaaggagag attatcatga caacacctta caaacacgag ccattcacaa 327481 atttccaaga tcaaaacaac gtggaagcgt ttaaaaaagc gcttgcgaca gtaagcgaat 327541 atttaggaaa agactatccg cttgtcatta acggcgagag agtggaaacg gaagcgaaaa 327601 tcgtttcaat caacccagct gataaagaag aagtcgtcgg ccgagtgtca aaagcgtctc 327661 aagagcacgc tgagcaagcg attcaagcgg ctgcaaaagc atttgaagag tggagataca 327721 cgtctcctga agagagagcg gctgtcctgt tccgcgctgc tgccaaagtc cgcagaagaa 327781 aacatgaatt ctcagctttg cttgtgaaag aagcaggaaa gccttggaac gaggcggatg 327841 ccgatacggc tgaagcgatt gacttcatgg agtattatgc acgccaaatg atcgaactgg 327901 caaaaggcaa accggtcaac agccgtgaag gcgagaaaaa ccaatatgta tacacgccga 327961 ctggagtgac agtcgttatc ccgccttgga acttcttgtt tgcgatcatg gcaggcacaa 328021 cagtggcgcc gatcgttact ggaaacacag tggttctgaa acctgcgagt gctacacctg 328081 ttattgcagc aaaatttgtt gaggtgcttg aagagtccgg attgccaaaa ggcgtagtca 328141 actttgttcc gggaagcgga gcggaagtag gcgactatct tgttgaccat ccgaaaacaa 328201 gccttatcac atttacggga tcaagagaag ttggtacgag aattttcgaa cgcgcggcga 328261 aggttcagcc gggccagcag catttaaagc gtgtcatcgc tgaaatgggc ggtaaagata 328321 cggttgttgt tgatgaggat gcggacattg aattagcggc tcaatcgatc tttacttcag 328381 cattcggctt tgcgggacaa aaatgctctg caggttcacg tgcagtagtt catgaaaaag 328441 tgtatgatca agtattagag cgtgtcattg aaattacgga atcaaaagta acagctaaac 328501 ctgacagtgc agatgtttat atgggacctg tcattgacca aggttcttat gataaaatta 328561 tgagctatat tgagatcgga aaacaggaag ggcgtttagt aagcggcggt actggtgatg 328621 attcgaaagg atacttcatc aaaccgacga tcttcgctga ccttgatccg aaagcaagac 328681 tcatgcagga agaaattttc ggacctgtcg ttgcattttg taaagtgtca gactttgatg 328741 aagctttaga agtggcaaac aatactgaat atggtttgac aggcgcggtt atcacaaaca 328801 accgcaagca catcgagcgt gcgaaacagg aattccatgt cggaaaccta tacttcaacc 328861 gcaactgtac aggtgctatc gtcggctacc atccgtttgg cggcttcaaa atgtcgggaa 328921 cggattcaaa agcaggcggg ccggattact tggctctgca tatgcaagca aaaacaatca 328981 gtgaaatgtt ctaagcggga ctaaatgggc atcctccctg cgggggtgtc catttcatcc 329041 atatactata aaaaagagga ggaagtgcca tagaaaacac acagctgatt atttcgattt 329101 gtatttatat ggcgggaatg ctgctaatcg gctactttgc ttacaagcgt acgtcgaatc 329161 tgacggatta tatgctggga ggacgctctt tgggtccggc agtaaccgct ctcagtgccg 329221 gcgctgccga tatgagcggc tggctgctaa tggggcttcc gggcgccatg ttttctactg 329281 gtctgagcgg cgcttggatc gtcatcggac tttgccttgg agcgtgggcg aactggcttt 329341 acgtcgcacc acggctgaga acctatactg aaaaagcggg gaattctatt acaattcccg 329401 gattcctgga aaatcgcttc ggagatcaaa caaagcttct cagactgttt tcgggaattg 329461 tcattttagt ctttttcacg ttttatgtat cgtccggaat ggtgtccggc ggcgtcttat 329521 tcaacagcat cttggggatg gattatcaca ccggcctgtg gattgtgacg ggtgttgttg 329581 tggcatatac cctgtttggc ggctttttgg cagtcagctg gacagatttt gttcagggga 329641 ttattatgtt tgccgcactc attcttgtgc cgatcgttac gtttttccac acgggaggag 329701 caggtgatac agttgctgaa atccgctctg tagatcctga tatgtttaat attttcaaag 329761 gaacgagcgt ccttggcatt atttctttgt ttgcctgggg gctgggatac tttggccagc 329821 cgcatattat tgtgcgtttt atggcgataa cgtctgtcaa agagatcaaa agagcgcgca 329881 gaattgggat gggctggatg attttgtctg cagtaggcgc agtgctgacc ggtttgggcg 329941 gaatcgctta ttaccatcag cgcggcatga cactgaagga cccagagacg atttttattc 330001 aattagggaa tatcttgttc catccgatta tcacgggttt tctgatttca gcgattttgg 330061 ccgcgattat gagtacaatt tcttcccagc tgcttgtgac atcaagctct ctggtagaag 330121 atttgtataa gtcgatgttc agacgctcag cttcagataa agaactggtg tttttaggcc 330181 gactggctgt tctggctgtt tcaattgtcg cgttggttct ggcttgggag aaaaataaca 330241 ccatccttgg attggtcagc tacgcgtggg cgggcttcgg tgcatcattc gggccagttg 330301 tactgctcag tctgttttgg aaacgaatga ccaaatgggg ggcactcgcc ggcatgattg 330361 tgggagcagc gactgtaatc atttgggcga atgccggtct ttcggacttt ctgtatgaaa 330421 tgatacctgg ttttgctgcg agtctattat ctgtcttttt tgtcagcata ttgacgcagg 330481 ctccgtcaca agctgtcaca gaccagttca acgactacca agatacaatg tcgcaataaa 330541 gatcgaaagg aggaggaagg ggctgtccct ttttcctctt ttctcctttt aagcggccat 330601 ttttttcttt tggaaacaaa cgtatttttt tctatacaaa aagaccccgt atggatatga 330661 ttaaagtaaa aaaagtatag gagaaaaagg tatggaagag cttttagaga gagttttttc 330721 attttcagat gttgataagc taattgattt tattagctat gaactgcaaa agccagtgat 330781 actggaaagc gcggatttct ttttgttagc ctataattct tactatatta accattttga 330841 ttctgccaac cagcagacta ttttttcgaa aaagtgtccg gtccagattt ttgagaggtt 330901 tctgaaggac ggaattattg aaaaattgaa aacagagcct gagccttttc gcgtcaataa 330961 aattgaaagc attgggttaa accagagggt ggtcgtgagt gcaaagcaca aaggggaagt 331021 catgggctac atctggattc aggagctgga ccaaaatctg acggatgaag agctcgactt 331081 tttgtacgag acctccttcc atgtcgggaa aatcatttat aaaacgaata aattgaaaca 331141 ggaaaaggaa gaaaaagcag aggatctcat caaacgggcg atctatcagc aatttacctc 331201 tgagaaggaa ctcagacggg aagctgaaag gatcaacacc gtgctgcctt ccatgttttc 331261 agttgttatc ctgcacgccg caaatgggga tggggaagcg gttgaggatt taaaggaaaa 331321 tatcaggtcg tacctgaatt tacgggataa ggtcagtcat gtcttaacga tcgaatcaaa 331381 cattgtcatc gtcgtagcga gtttttccca aaaaagctcc gtctcctcag cagcttctga 331441 gtttattaac aagctgttaa cacattttca ctttcaaaaa atacctaccc ctatttatat 331501 cggtatcgga aacgaatata atcacctatt aaaacttggc aagagctaca cagaagcact 331561 tgaagtcatc aaagccgcag aaatcaccgg caatcaggaa aacattccat atgaatatgc 331621 caaactcggc atttaccgct atttagaaag catcgaacag aaaaatgaat ttttagaata 331681 cgagaataaa gatttagctt tattaaaagc aaaagacgaa gaaagcagca ctgagctgct 331741 caaaaccttg gaaatctatc tcctcaacaa ctgcaaaaca aaaccagcgg cagaacagct 331801 gtttattcac caaaatacat tgaattaccg catcaaacag attactgaga tgacgtcgat 331861 cgatttaagc gatttcagaa cgcggtgcca gctctatctc gatttgatgc tgatgaaaaa 331921 gaaataaaaa agaaaccagt acttgtactg gtttcgtctt cacttaaaat cctctgtaaa 331981 catacggatc atcaggtttt ttaatggtat tccagtcagt tactttgacg acagggagag 332041 ttgacttgaa tggctggtaa tattctgagg ccagagtgcc cttaatgtga atccattcat 332101 catccttgat gtccatgtcc ttcggaaatt ccacaagcat cccgtacacg ccggaatcag 332161 cgatacagtg aatgatgcca aaccttaata cgaacagctg atttttgtta attgcgtttc 332221 ctttgtaagc aaatccatga aattctatcg tccgtccgag aaattcaccc ggatagttat 332281 agatggtttc cattcctttt aggaaatcgt catcggtcag agaaatctct tttttgctgg 332341 aatacttatt aaacagctgt ttcatttgtt tgtcatagct gtcttgcgcg taataaaggc 332401 tggcatcagg ccgcaaatac tgtgtttggg agtagtgatc tccgctctcc atcgccttaa 332461 acgagaaccc ttttgttttg actatggatg agtcaagcgt tgcaatcggg aagaagatgc 332521 ctgacaccaa aggaaaaaga aaaacaacat aaatcaaata acgctgataa aatggcttgt 332581 tttgttcatg gtcatgctcg tgatcatggc cgcacccgca atcatggtca tggtgatgtc 332641 cgcttttttc aggcgacttg ataaatagat atgcttggac ggcggtcaga atggccagca 332701 ggaagatcgc aataaaggaa agataggcat atttcatatt gatatatttt gttagatttc 332761 ctgaggcatg cagatgataa aagaaaaacg taaatcccat cagcaccaat aaacgaaaca 332821 tccaatcacc cctttaccag tagtgatccc gctaaaacaa tcacgacaat gtatgtaatc 332881 agcaggaaaa caaatcgttt tttgaaggcc gcaagcatca tcaatagatt cttaatatcc 332941 accattgcac caaagacgag aaaggcgatt aacgatccta atgaaaacgt gctgctgaag 333001 gaagacgcga tgaacgcatc aacttctgaa caaagcgaca ggacaaacgc cagacccatc 333061 atcacgaggg aagaggatac atcattctgc ccgatcgcaa gcagagtgga tgttttgaca 333121 tacgtctgca tagcggctgc gataaaggcg ccgatgatta aatatttccc cacggagaaa 333181 aattcatcaa tggcatgccg caaggtcccg cccagttttt ggagcaaggt gccgtgatga 333241 tgatggtggt gcccgggttc atcaggcttt aaaagctggt tatccttaaa ttgataggat 333301 aagatgaccc cgatgatcag cgaaacggcg agagccagtc cgcctctgta aaagaccacg 333361 ctccatctat tcccgaacgc aatataagta gaaaataaaa cgataggatt aatgataggc 333421 gcggtcagca tgaaagcaac gcccgcatgc agaggaactc cctttaacag aagccgcctc 333481 gtaatcggga tgatgccgca ttcgcaggcg ggaaataaaa cgccggccag cgcaccgaat 333541 aaaacggcga gaaaacggtt tttcggcatg attcttgcaa tcatttcttc agaaacaaac 333601 atttgaatga ttccggaaag tatgacgcca atcagaataa acggaatggc ttctattaaa 333661 atgctgataa aaatagaatt cagctgaaga aaagatgatt gtgctgtcac aataaaacct 333721 ccgctcatgt taagctgcct ttcttatgat accagaaaaa aaggcactgc ttgtttgacg 333781 gaggagggga aaggatcgtt tcactttggt taggattcca aaaagccgag taggatactg 333841 cctgtttctg cagcttcttt tccgagccaa atcaggtgtc cccatgagtg aagcaaacag 333901 agaacagcgc cacgaatgtg ctcttttgca tgatgtgcat gtgacaagtc aaccaatccg 333961 tcataaacac tttgcataat cagcacggga catatgatgg cttgcaggtc ttttaaagag 334021 acagcggcgg tttgtgacaa gtcaatcaga aatccttcac ccgagcgctg ccggctgttc 334081 attttccgaa atgcttctat gtctttttca ttcatcaagg acttgattcg ctgaaacgga 334141 agcgtgctga attgggggct catagctcga aacatcaaac gcgggaaagc gttattcaag 334201 gaagaaatca gcttccatat ccacttttcc accggcgggc ggaagagaat ttcccccaat 334261 ttatattcag tgtcttttgg ggtgagccac tctttggtga ctgcggattg cagggtcaat 334321 gtatttactc tttccggata atgtgaggca aagcatatgc cgctcggccc tcctgctgag 334381 atggcgatca catggacact ctcgatttgt agatgatcta ataatttcac atagaaacgg 334441 caggcattgg caagactttt tccaatttct tttgacgtcc gtccatagcc aggccttgaa 334501 ggcgtaatga tggaataccc ttgttcaatc aacgctgtgt atccgaattc ctcgtaacaa 334561 tttgaatgcc cgccatgcat gacaaggatc ggagttccct tgcctgtcac agaatattct 334621 agtgtaccgc catcgaaggt gatcgtttca actcgtcttt tcatctgttt cacccaattg 334681 gtttttgcct attatagagt tttcagcaat tgaccacaag gtagaagaaa tgaataaaca 334741 aaggcccttg aaatatgata tactttgtat tgatattcat tctcaattaa aactttgata 334801 tagatgtgaa cgggaggcag gacggatggc tgagaatcaa gaggtatatg acgttacgat 334861 tataggcggg gggccgatcg ggctgtttac tgctttttac tgcgggatgc gggagctgaa 334921 aacaaaggta atcgaatttt tgccgaagct cggagggaag gtgtctttat tctttcctga 334981 gaaaatcatt cgcgatatcg gcggcatacc ggggattgcg ggaaagcagc tgatcgagca 335041 gctgaaggag caggcggcaa cgtttgatcc tgatatcgta ttgaatcagc gtgtgaccgg 335101 gtttgaacgc ctagatgacg gcaccattgt tctgacgggt tctgaaggga aaaagcacta 335161 tacaagaact gtgattttgg cttgcggcat gggtacactt gaggtcaatg agtttgacag 335221 cgaggatgcg gcccgatatg cgggcaaaaa tcttcattat ggagtggaga agctcgatgc 335281 gtttaaaggg aaacgcgtgg tgatatcagg cggcggagat actgcggtcg attgggctaa 335341 tgagcttgaa ccgattgcgg cgtctgtgac tgtcgttcat cggcgtgagg aattcggcgg 335401 aatggaaagc agcgtgacga aaatgaagca atcatcggtg cgggtgctta cgccttatcg 335461 gctggagcag ttgaacggag atgaagaggg catcaaaagc gtgaccgttt gtcatactga 335521 gtctggccag aggaaagaca tagaaattga tgagctgatc attaatcatg ggttcaaaat 335581 tgatctcggg ccgatgatgg agtgggggct ggagattgaa gaaggaaggg tgaaagctga 335641 cagacatatg cgaacgaatc ttccgggcgt gtttgtggcg ggcgacgcgg ctttttatga 335701 aagcaagctg agattgattg ccggcggatt tacggaaggc ccgacagcgg tcaacagtgc 335761 caaggcttat ctggacccta aggccgagaa tatggcgatg tattccaccc atcataaaaa 335821 attggtgcat aaataaaaca gcccttgagg aaaagggctg cttgccatca ggtgtgaagg 335881 agttttttct ctgcatgttg attgtggatg aaagctagca attcatcctg ttcttgtacg 335941 gctgtgaatc cataaatgcc ggcagctgag tcatcgccta tgcagacgat aggagggcgg 336001 cttgctgacg gttccggcaa aatgccaatt tgttcgccac cattgatcaa ttgctgaacg 336061 gacagcttgt ttgggcaaat gaccatgtgc agcggggatt cactgatggt acgctgaatc 336121 atgtgggtga accggtcatc tatgacgttt tcatgagtga tataaaacga acaggattca 336181 tgcttttgca tgttttccac tgcatggcgg ctcccgacaa caagacgttt ctctgaatca 336241 ggctgaatgg cggtgacaag aaagccccgt ttctcaagct ctgtctttgc ttgctcagat 336301 gctgcactca gtttggctgt cagctggcgg atgtcgattt tctgagaagc cagtgctctg 336361 aaaaattcac aaaccgcccg gcgcgatgtg aaaaaaacgt cttcaaaggt gccaatcttt 336421 cgaagaattt cttcattgac aggcatgttt tcggtccgcc atttcggcca ctcgatgaga 336481 tcggcgccgg aatcgcgcag cttgtctgca agcgggtctt catcttcgcc atgagtcaca 336541 accatcaaat gccgtccgat gagcggtttg ctttcaaacc agctgtgtgt ttgaaagttg 336601 acgatgtctc cgatgacgat aatcgcaggg tttgtaatct ggtgttcctg cactttttgc 336661 tgaatgttct caagtgttcc tttcacactc cgctggcggc cccacgttcc ccattggatg 336721 acaatgacag ggacagaagg cgatttcccg tatgaaataa gctgctggca aatataagac 336781 aagttcttga cacccatgta aaaaacaagg gtttgaacgc ttcgggccag cccttcccag 336841 tcaaggttcg gcgtgccttt taatgattta tcatgcgctg taatcatggc aaaagacgat 336901 gcaaaatccc gatgcgtgac ggggatgccc gcatatagcg gcgctgcaat tccagaggtg 336961 attcccggca ccatttcata gcgaatgccg tgctcatgaa gagcatctgc ttcctcgccg 337021 actctgccga atacgctcgg atctccgccc ttcaagcgaa cgacggttaa cccatttaat 337081 gctttttcaa ccagcagggc gttaatttct ttttgtttca taaaatggcg gtttggcagt 337141 tttccgcaat aaataaactg gcagtccggt gatgcaaatt cgagcagctt cgggttggcg 337201 agccggtcat ataaaatcac atctgcttcc ttgagcgcct gttttccttt gatggtgagc 337261 aggcctgggt cgccgggtcc ggctcccacg aaatatacga ttccgttctt catgatcatg 337321 tcatccttcc gtcactgtaa aaaatgaagg accactagaa aagtgatccg gtcttttgat 337381 caatatacga gataaacatg ttctccttcg atcagcgttt catatgtttt gacgcatccg 337441 tggtcaggtt cttggacgat tccgtcttct aaggaaattt tccagtcgtg catcgggcag 337501 aaaacatatt gaccgctgac gatgccttct gccaggacgc cgcccttatg cggacagcgg 337561 ttttcaatgg cgcggatgct tccgtctgaa agcttgaaaa ccgcgagctc cttatcttca 337621 atatacactg ttttgcctaa ttgttcaggc aattcttcaa tttttccgat acatactttt 337681 gttacgtctt tgtttaccat gtccattcct cctcaatgat agtttttgtc attatgatgt 337741 ggtcacgaca ttttcaaata attctttaga ggtttgttta tcctctaaaa agtctttcca 337801 cggatccttg tggacagaga gtgtttcatt cattcggccg ttcagctcct gccgcttttc 337861 cggatcgttt aacacggatt ggacatggga taaaccgacg cgctcaagcc atgcggacgt 337921 acgctccaga tagtttgcgg tttccctgta atattgcagg taagcgcccg cgtattctaa 337981 gacttcttca tttgttttca ccttcatcag caaatcgccg gcacgcaaat gggttccgcc 338041 gtttccgccg acataaagct cccagcctcc gtcgatgccg acaacgccaa ggtccttaat 338101 gccggattcc gcacagtttc gcgggcaggc agacacggcc attttgactt tgtgaggcgt 338161 gttcagccct tcgaattttt tctcaagcgc aatgcccagt gccatggagt cttgtgtgcc 338221 gaagcggcag aattgctcgc ctacacatgt tttcactgtg cggagcgttt ttccgtacgc 338281 gtagcccgat ggcatatcaa gatcttccca taccttcgga aggtcttctt ttttcacgcc 338341 gataagatca attcgctggc cgcctgtcat tttcacgagc gggatctcat atttgtcaac 338401 gacatcggcg atcttgcgca aatctgtgga gttggtcacg ccgccgtaca tccgaggaac 338461 gactgagtat gttccgtctt tttgaatatt ggcgtgcatt cgttcattaa caaagcggga 338521 tgtccggtca tcctcgtatt tggttggatt gatcatgcct aagtagtagt tcagagcggg 338581 tcggcattta gaacagcctt ctggcgtttt ccagccgagc acattcatga cttctcttgt 338641 atgtgacagc cctttggctt tgatttcttc tacgacttca tctctcgaca atgtggtgca 338701 gccgcaaatg gcttcttttt gcgctgacgc atcaaagtct gatccgagcg tatgctggag 338761 gatttcttct acgagcggct tacagcctcc gcatgagcgg gatgcgccgg tgcatgcttt 338821 gatttcgtcc gttgacgagc agcccttttc ctgtatggct tgaataatcg caccttttga 338881 cacgccgtta cagccgcaga tgatttcatc gtcgctcatc gctgcggtta tgcttgtgcc 338941 tgcttcctgg ctgaggggct gtaagattga tattttagag gtttcagaga tatcggcttc 339001 tttttgaatc atagaaaaca ggcgattgcc ttcgctgctg tcgccgaata aaacagcacc 339061 gacaatttga ttgcctctca ggacaatttt tttatagatg ccgtcctgct catcgaagac 339121 tttaatcgct tttttctcct ctgattcgtt aaagtcaccg gcagagaaga cctcgacgcc 339181 tgataccttt aactgtgtgg agagaacgga gccctcatac ggttttgttt cgatgccgca 339241 catatgcttt gccagcactt ttgcctgttc atacagcggc gccacaagcc cgtaggcgat 339301 tcctcggtgc tcggcacatt cgccgaccgc gtaaatgtgc gggatttcag tctgcatata 339361 atcgttgacg atgatgccgc ggttaaccgg aatgccgctc tcggccccga gcgttgtatt 339421 tgggcggatg ccgacagcca tgacgactaa atcagcttca atgcttgtgc catccttgaa 339481 tcggaggcct tcgacacggt cgtcaccgac aatttcttct gtttgctttt caagtaaaaa 339541 ggtcatacct tgtttttcta actcgttttg cagcaggcgt cctgccgttg catcaagctg 339601 gcgctccatc aggaatgggg caaggtggat gacggacacg tccatgccga gattcagcag 339661 tccgcgagct gcttccaaac caagtagtcc tccgccgatg acggcagctt ttttatattg 339721 ttttgacgcg gcgagcattg tgtctgtatc ttttatgtcc cggaaagctg tgacgccttt 339781 tttgtctgcg cccggaatcg gaaggataaa agggaccgat cctgtcgcca ggatcaattc 339841 atcgtaaggc tggattctgt ctgcatctgt gatgactgtt ttgttttccg tgtccacttt 339901 gatgactgtt tcatttgtat acaattgaat gttgttttct tcgtaccagt cccaatcgtt 339961 taacgtaata tctttaatat ctgtatcgcc ttgaagcact tttgacaaaa ggattcggtt 340021 gtaattggga tgcggttcgg caccgaaaat tgtgatctga aactcgtctt tagcaacact 340081 cagtatctct tcaatggccc ttaccccggc cattccatta ccaacaagaa ctagctgttt 340141 ttttcccatc agatgatccg ctccttatca aatgtttttt ccagcgtagc acagcaaaaa 340201 ggaatattta agatacatgt tataaaatgt aacaaaatat acgaaaagtt ctaaaaattt 340261 tatgaaaaat ttaaataggt atgattcgga cggcgcatac cttaaaaccg ggcattttac 340321 aggctggatc taaggcttcc ccgattaaat cattcacatt ttgagcgtct gcccaatgga 340381 tgggaacaaa aacggtatct tttctgattt gttctgataa tttgctgcgg acggtgatgc 340441 ttccccgcgg cgattctatt tttaccagta cacggtcctc gatattgtag gtcgctgctg 340501 tttgcggatg gatctccata aacgattcaa aatgtctcgc ggcaagggcg gcgctttttc 340561 ttgtttggac gcctgttaag tagtgagaca tgactctgcc tgtcgttaaa taaagcggat 340621 aatcggctgt cggcttctct tttggaacag gtggttcgtt tggaatcaca cttaatgccg 340681 ctttttgatc cggatgagca aatgattctg taaacaagcg cccagttccg ggatgatcag 340741 attccggaca cggccaatga atgccgcctt cacgtctgag cctgccgtat gagatgcctg 340801 aataatcggc aatcccgcct cggctcgctt ctctcaattc attgaaaata tcctccgctg 340861 acgtataaga aaagtagcgg cccttgccga gagcggatgc gagatcacaa atgatctgcc 340921 aatcatgctt tgcttcgccg gggcatggcc ggcttgcttc tcttaatgtc acgcgtcctt 340981 ctacatttgt catggtgcct tcatcttcta agtaagagga ggcaggtaaa atcacatctg 341041 cgtatttcgc agtctcagaa ataaacaaat cgattgcgac aaagaatgtc agtcttctta 341101 aagccttttt cacgagattt gcatttggac tggaaacagc agggttggag cacatgagga 341161 acagtccttt gatgtcgccg tcattgattt tttccatcat ttcataggct gagacacctt 341221 ttcgcgggag ttcatcctga tggattcccc acactttcgc aatatgcgcc cggtgttctt 341281 cgttttcgat agaacggtag cctggaagct gatcggcttt ttggccatgc tctctggcgc 341341 cttgcccgtt gccttgtccg gtgatcgccc cgtagcccga gtaaggtttg ccgatttttc 341401 ctgtgatcag caccatgttt aagaagcctt tcacagccgc tgttccatcg gtttgctgtt 341461 caatcccgcg ggctgtaaac agcatgccgg acgtttcctt ggcaaacttc acagcagctt 341521 ttcttatatc caccagcgag acactcgtct gttcggcgat gtcattcagg tccaacgagt 341581 cagtatgctg cttcagctct tcgaatccat ttgttcgtga ttgaatgaaa tcctcgttta 341641 taagctgttc gtcaatgatg attttgacga gaccgttggc aagggcggcg tctgtgccgg 341701 gtttgatttt cagatgaaga tcggcgattt tcgttgtcgc tgtttcacga ggatcaatgg 341761 caatgaagta agctccgttt tctttcgctt tttcaaaata cggcataatc gtaggctggc 341821 attccgcaat attggtgccg gccagaatga tcacacgggt gtgggggatg tctgataaag 341881 gattcgttaa gcctctgtcc gcgccgaatg tttggttggc tgcggtggct gctgcggaca 341941 tacaaagtct cccgttgtag tcgatgtatt ttgtctgtaa gcctactcgt gcgaacttcc 342001 ctaacaaata cgcctcttca tttgtaatcg aggcgcttcc gtataccgcc atggcgtcat 342061 gtccgtgttc agtttggatc attgtcactt ggtctttgat atgattcagt gcttcttccc 342121 aggaaacagg cataaactcg ccgtttttct tcagcagcgg ccgggtgatg cgggaggagt 342181 tcaaggcatg ctggtgagca ttcatgccct tgatgcatag ccgaccctgt gtcgtaggat 342241 tatcaatccc gatcgcagtg tactttttgc gcgtgacgat ggtttgttcc acgagctgca 342301 ttttgcactg catgctgcaa aacgggcatt gagtgtcata tgttttttct gattggacgt 342361 cttgctgttt atcacggaaa tatctaagca gtcgttcagt caaaatgcct catcctttct 342421 tatatgcgcc cgtctctaca gtcgggtttt gaatcagtga cagatctgtt tggaggcttt 342481 ccagcagctg tgcccttagg tcttcttcga atagcacttc tctgatatga acgatcccga 342541 gacggtctat ccactgatga acaccttcta agtaatgagc cgtttcccga taatactgga 342601 tcagtccttt gatcatgccg gcagtgctgt cttcgttctc agtcacgcaa aacaaagctc 342661 ctgaacgggc atgagttccc cggacgccgc cgatgtgaat gtcccagcca gcttgtgtcc 342721 gaattgcgcc gacatcttgc agggcggcct cggtgcagtc tgtttcacat gataagctga 342781 tagaaatggg agcgggtaag ggaagcatct caagttgtct ttcgatttgg gctgccagct 342841 gctgaatcga tcgattttgc ccgcatgtac atgctttgat gctttgcagc gcgtgtcggt 342901 gttcattagt gtaaacgggc attttcaggt cttttttcat gttcgggaga tccgcaggct 342961 tgatcccgga aagcttcagc ctttggccgt gagtgatgga tacgtcggga atgctgtatg 343021 cctcaatgat gttggcgatg gttcttagct gctccgcgtt tgtccgcccg ccgtacattt 343081 gcggaatcag gatgcatgtc tcttcagtgg ctggctcagg ctggacaaac ccagggtaca 343141 gcatttccag atagtattga atcgcaggaa cacaagtact gcatccgttt tttgttttcc 343201 agtcaagctg gttcatcact tctgccggat tagtgaatgg cctgcgctga agctcagcga 343261 tgatgtcgtc ttctgtaaaa tcagtacagc tgcaaaacga aggtgtgctg gcgggcttcg 343321 tatattcgct gttggtcatg tatctcaaaa ggtcttcaac gagcggtttg catcctccgc 343381 aggacccagt ggctttggtg cagtgcttga cttcctcaac agttgttaag ctattcgtgt 343441 gcaccgcgtc ttcaatcgcg cctttcgtca ctgtgttgca ttggcaaatc gtttcactgg 343501 aaggcatgga ttcaaataaa gggccgcttg tctccggttc gatgatctgt tttttggcaa 343561 tggagatgtc tcgttgttta agcaggctgt cgagaagccg ctgcttgtca cgggtgtctc 343621 cgaataaaat aacgccggcc agtttgtcat ctacaaaaag cgctttttta taaacgcctg 343681 cttgttcgtc gtagattttg atgctcgtcg tgcgttcatc ctcttggatc tttcctgctg 343741 accacacatc gattccagct atttttaacg ccgcagatgg tgctgagcct tgatattcct 343801 cacatggaac gccgcaaata tgactggcga gcgcttttcc ctgctcataa agcggagcca 343861 ccaatccgta caccgttccg ttatgctcag cgcattcacc aacggcgtag atattcggtt 343921 cgcttgtctg catgaagtca ttcacgatga tcccgcggtt cactttgatt ccagcggata 343981 cagccaattc aatattcggt ttgacgccgg ccgccatcac aatcaagtct gcttttaatg 344041 aagagccatc tttaaaatgg attcggtctg ccttcgtggc gccggaaatg gagacggtgt 344101 ctttctccaa aagaaaggtt aggccttttt gttccagctc tgtttgcagc agccgcgccg 344161 ctgtttgatc gagctgtttt tgcataatgc cggcggagtg gtgaatgacg ctgacatcca 344221 taccgagatg ctgtaaacct actgcagctt ccagtcctaa taagccggct ccgattaccg 344281 cagccttttg aaagtgctgg gccatgttca tcagcgcttg gcagtcttct attgtccgaa 344341 atccatagac accttttttg tctgccccgg ggatagggag aatatgaggg gaggagcctg 344401 ttgccactat taatttgtca tacgacagag tgcgtttccg atctgtgatg acctgctgct 344461 gatctgtatc aatctgaata accgtttcgc ctgtgtaaag cgtgatcccg tgcttgtcgt 344521 accaatcctt gctgttcagt gtaatatcat cgagtgacgc ttcaccctgc aatacagagg 344581 ataagagaat gcgattgtaa ttgggatgcg gctcgcttcc gaaaatgaca atctcaaaca 344641 tgtggcgatt cagctttaat acttcttcaa tacagcggat tccggccatg ccgtttcccg 344701 ctaacactaa tctttgtttc ttcatgtatc agacctcctt tggcgaagct cgtaagtttt 344761 ctcctattaa aaattatgtc acaatgcatt gttaacgcat taaacgtgtc acaaaaactt 344821 acacatgtct tttccagaaa ataatggtcc tatatccttg attcagaaaa tgtaaaataa 344881 tgagggtcta gaaaggggaa tcttatgaag ctgtcggaac tgaaaactag cggtcatcca 344941 ctcactttgc tctgttcctt tttatacttt gatgtcagtt ttatgatatg ggttatgctt 345001 ggggcgctgg gtgtttatat ttctcaggat tttggcctgt ctccttttga gaaagggctt 345061 gtcgtagctg tgccgatttt atctggatct gtgtttcgta tcattcttgg tattttaacg 345121 gacagaatcg gaccgaaaaa aacggcagtg atcgggatgc tggtgacgat gattccgctg 345181 ctttggggga cattcggcgg ccgttccctg actgagctgt atgccatcgg gattctgctt 345241 ggcgtggcgg gagcaagctt tgctgtagcg ctgcctatgg ccagccgctg gtatccgcct 345301 catttgcagg gacttgcgat ggggattgcc ggagcgggga acagcggcac gttgtttgca 345361 accctgtttg gccctcgtct ggcagagcag ttcggctggc acattgtcat gggaattgcg 345421 ctaattccat tattgatcgt ctttattctt tttgtatcca tggcaaagga ttcccctgca 345481 cagccgtctc cccagccgct caaaagctat ctgcatgtgt ttgggcaaaa ggaaacatgg 345541 tttttctgcc tgctgtacag cgtcacattt ggcggatttg tcgggctctc aagcttttta 345601 tctattttct ttgttgatca ataccagctg tcaaaaattc acgcagggga cttcgttaca 345661 ttatgtgtgg cggcggggag ctttttccgg cctgtcgggg gcttgatttc agatcgtgtc 345721 ggcggcacga aagttctttc tgtattgttt gtcatcgtgg cactgtgtat ggccggagtc 345781 agtagcctgc catctctctc aatggttatt gttctattgt ttgtcggaat gatggggctc 345841 ggaatgggaa acggcgcagt attccagctc gtgccgcagc gcttccgcaa agaaatcggc 345901 atggtgacgg gaatcgtcgg tgcggccgga ggaatcggag ggtttttctt gccgaacatc 345961 ttaggatctc tcaaacagat gacaggcaca tatgctatcg gttttatcac gttttcctgt 346021 atcgcgctgc tggcgtttgc acttgtgctt gccgcaggct attactggcg gaaaagctgg 346081 agcgcggaaa gcagcccggc ggatgtttag gattttgacg gacacgcgtt tgtgcgtgtc 346141 ttttttattt tctcttgatt ttcaacagtg aaccgatcaa aataaatagt aattattacg 346201 atttgttagt gagaggagtt ttctgaatga atcaacatac gctgctcccg aaaaaaacgg 346261 agcgtcttca atactttgga tcggtcagtc cgatcaaagg cgagaaacca gtggaaaaag 346321 agaaaatgaa ggacctgcaa aatatcagga aggattattt ttttgacatt cagcatgtag 346381 gtgtagctaa tgtgtcccat ccagtcacaa tcacttctgc catgatgcct gccgagcaaa 346441 caacggctgc gaactttaca atgacttgta atttgccgag aaatcagaag gggattaaca 346501 tgagccggtt aacagagctg ctgcaagtct atcatcaaaa tggctggatt ctctcatttt 346561 cctctcttca gcaatttacg aaagagcttg cagaaaacat ggacacatca tctgccacag 346621 ttgaagtgag gtttccgtgg tttttcgaac ggaaaagccc gaagcttgag aaagcgggtt 346681 tgatgcatgc tgatatattc atgtctgtca cctatcgcaa agatcagccg tttaaacagc 346741 gtgccggcat ctcagcaaaa gtaacgactc tgtgcccttg ctccaaggaa atcagcgaat 346801 acagtgccca taatcagagg ggaacggtca gcatttgggc ggatattcac ccggccgcat 346861 cgctgccaag tgatgttaaa gctgatttgc ttcacgccgc agaatcaaat gcttctgcga 346921 gactgcatcc ggtattgaag cggcctgatg aaaaagccgt gacagaaacg gcctatgaaa 346981 acccgagatt tgttgaggat ctcgcccggc tgattgctgc agatttgttt gagcttgaat 347041 gggtgtcagc ctttgagatt gaatgccgaa atgaagaatc gatccatctt cacgatgcct 347101 atgcgaagct gtgtttttcg aaggaagtgg ataaaatatg aaactctcat tattcattat 347161 tgcagttctt atgccagtca tcctgctgtc agcctgctcc gatcatgcag aagaacacgc 347221 aagtatcaat acaaagaaaa cggtcgaaaa cataacggac gttcgaaaaa cagcaaaaac 347281 aagcattgat tggacaaagc cttcgggcgg agaatacccg gatattaaac agaagcatgt 347341 ctggattgat gtgaatgtga aggagcagaa ggcttacatc aaggaaggaa gcaacaccat 347401 ctatacaatg atgatttctt ctggtcttga tcaaacaaaa gatgatgcta cgccaaaggg 347461 caccttttat gtagagcctg aacggggaga atggtttttc tccgaaggat accaggaagg 347521 cgcagaatac tgggtatcat ggaaaaatca cggtgaattt ttatttcata gtgtgccaat 347581 gactaaggat caaaaagtca tcaaaacgga agcagaaaaa ctaggaacga aagcatctca 347641 cggatgtatc aggctgacca ttccagatgc gaaatgggta tatgaaaata tccctgaaca 347701 tacaaaagtg gtgatcagct gaattgaaaa ccgttgacaa aaaggaaaaa agaccataca 347761 atttaaatcg taacaattac gttttatgat aaatggctta tcattgtctg tgcatctgtg 347821 aaaagcggaa aggcatcgat taaggatctt gctgtcggca aaggcaagga tttgcgatgg 347881 ggaaaaggat taaacgcggt tggagtcttt actgatttag aaatcgggcg gcagcgagaa 347941 atgagcgcga aaagctgctc tacaccattg tacatacggc gaagtattca atttaaatcg 348001 taatcattct attttaatgg aggcactatt atgaaaaaaa ttccggttac cgtactgagc 348061 ggttatctcg gtgcgggaaa aacaacattg ctgaacagca ttttgcaaaa tcgcgaaggc 348121 ttgaaaatag cggttatcgt aaacgatatg agcgaggtga acattgacgc gggcttggtt 348181 aagcaggaag gtggcctttc cagaacagat gaaaagcttg tggaaatgtc aaatggctgc 348241 atttgctgca cgcttcgcga agacttatta attgaagttg agaagctggc aaaagacgga 348301 cggtttgatt atatcgtcat cgaatcgaca ggaatcagcg aaccgatccc ggtggcccag 348361 actttctctt atatcgatga agagatggga atcgatctta caaaattctg tcagctggat 348421 acgatggtga cggttgttga tgccaaccgt ttttggcatg attatcagtc aggcgaaagc 348481 cttctggacc gcaaagaagc attgggggaa aaggatgaaa gagaaatcgc cgacctcttg 348541 atcgatcaaa ttgagttttg cgatgtactg atcttaaata aatgtgattt ggtcagcgag 348601 caagagctcg aacagcttga aaacgttctt cgtaaactgc agccaagagc caggttcatt 348661 cgttccgtca aaggaaatgt aaaaccgcag gagattttgc atacagggtt atttaacttc 348721 gaggaagcga gcggatcggc cggctggatt caagagctga cggcaggcca tgcggaacac 348781 accccggaaa cagaagaata cggtatctct tcatttgtat ataagagacg tttgccgttt 348841 cattctacac gattttaccg ttggttggat caaatgccaa agaacgtggt acgtgccaaa 348901 ggaatcgtct ggtgcgcatc tcataacaac ctcgctttgc tgatgtcgca agcaggtccg 348961 tcggttacga ttgagcctgt atcttattgg gtggcggcgt tgccgaagct tgagcaggag 349021 caagtcaaac agcaggagcc ggaaatcctg gaggagtggg acccggagtt cggcgaccgc 349081 ctaacgcagc tagtttttat cggaactgac ctggatgaag aaacgatcac gaaagagctt 349141 gatcaatgcc tgttgactga gtatgaattt gattccgact ggtcgctgtt tgaggacccg 349201 tttaaatgga agctgaatca atagaaaaaa agccgtccca tggggaacgg ctttttttaa 349261 tgaaacgttt gtttaaacat aatgagcgta ttttttctca aggatattct gaaagaccgc 349321 ggcaatggag cagatggccc aataaatgag agcggtcaga atatacatgg tcatataatc 349381 aaactctctg cccccgatga ttttcgcatg ctggagcaat tccggcactg taatcatcgc 349441 agcgagagag gacgccttga tcaagtcgag caatacattg gcaagcggag gcagcgcaat 349501 acgtatcgat tgcggcaaaa tgatgcccct catcgtctgc caataggaaa gacccagcga 349561 ggatgcggct tcccactgtc ctttttcgac ggatgaaatg gctgaacggt taatttccgc 349621 aatgtaggcg gcgctgttta ggctaaagcc gattaaagca gccgtgacag cggaaaattc 349681 aatgccgata taaggaaacc cgaaataaag gataaacaaa atcaccaaaa tcggaacgcc 349741 tcgcataaat gagatataga gcttcgccgg ccatcttaac aaagcaagtt tagacattct 349801 ggcgagtgat atgaacaggc cgatcacagt tcccgcaaac atgcttacaa aagagatgag 349861 cagtgtataa ccaatgcctt ttatgacata agggaacgat tcaatggcca gcttcgtgtt 349921 gaaaatatat tcccactgaa tgctattgat catggcgtcc gattacaaat caacgtcctg 349981 aacgtcggca tcaatttttt ttgatacatc tgctttattg aagaattgtt tcgacagttt 350041 agtcaaagag ccatccttgc tcatctcttt caatgcttcg ttcatctttt tctgaagtgc 350101 cgcattgctt tttttcatga caagggcctg tttgttcggc atgtacttga tgtcaggatg 350161 aattgtaatg ttgagatccg ggaatgccgc gagcgcaagt gtctgcaggt aatagtcgtt 350221 taaaatgacg tcagtgcgtc cgttggcaac atcttttaaa tattgctcat tcgtcgcatt 350281 atcataaatc acttctttgg cgccgtattt tctcgcgacc tccatgtaga cggttgtagc 350341 cgcgccagcc gctttcttcc cttttaaatc cttgagcgtt ttaatccctg ataaatcgtc 350401 ttttcggaca attgccgtgc cgtatgaata tttatatgga gtggaaaatg cgaacttctc 350461 ctcacggtcc ttcgtcacat cgatgtcatt cgcggctgcg tcaacctgtc cgctgttcac 350521 cgctgtcagc atcccgtcaa tgcccatctc cttgaactca accttcagcc ccaagcgttt 350581 tgccgcttca cgaacaactt caacctcgta gcccgtcagc ttatcagagc cagagtcagt 350641 atcgtgataa gaagtgggat agagcgtacc tgatgtagcg actacgattt tccctttatc 350701 cttaatctgc tcccagcctg tatccttgga atcggcttca tttttgccgg aacaggctgc 350761 caatataaga aagaaagcca ttgtgaaact gaatataacg gctttggaat gcatgaatga 350821 tttcacctat agttccccca atctgttaat caactaaaaa gatagcattg aacataaggg 350881 gttgcaatat gttgatcgcg ttttcaaaaa gttcgaattg tgtatacaaa aagcatgggt 350941 gggtgtttaa aagcgtctat gaagggaaga ggtgatgaaa aaaggaattg tccaaggatg 351001 aatgccagac gtaccaagga aacgcatgtg aaagtgaagg atgcagcaga cccgtcactc 351061 atctatgcca ataccggaag aaatggtcaa gaggcatgaa accgatcttc agaataaatt 351121 taagtcttgc tgatgcccct aaggcatatg atatattcga tgagaaagaa aatggaaaca 351181 tttaaaccat aatggggagt caaatgaata tttacaaacc agccggattt tggatcagac 351241 ttggagctgc attgttagac tacattatag tctccgtgcc gcttttgctg atctattggc 351301 tgattacagg aaaagaccca aacgacagca tgttcatcag tttggttgtt ctgctgtatt 351361 ctattttgct gccgatgttt tggcgcggtt atcttatcgg aaaaaggatc tgcggaatca 351421 gaatcgtaaa aaaagacgga tcacaggtca gtctgttaac aatgttttta cgggttattg 351481 tagccggcct ggtttactgt ataaccttcg gactcggctt gatcgccagc ctgattctga 351541 ttgccgtacg agaagacaaa cggaccctgc atgatttaat cgcgggaaca tatgtcactt 351601 atgcgacacc aggtgaagag gaacttaatg ctgacgaaga gattagaaag agcgaataat 351661 ggttcgctct ttttattttt atgcataaaa aatacaaggc agcaaaacat atgaaaaata 351721 ggattggagg aataaaatgg atgaaacgaa taaccatcaa cattatcaca atgttcattg 351781 cagcggctgt catttctctg accggtacag ctgaggccgc tgaaaaacag cagcagtctc 351841 ccgcaaatgt tacactgaca gatcagcaaa agaaagagat tgaacaactg gaagcagaga 351901 ttcttaaaaa gcgcaaagac gtgatctcaa agtatgtaca atacggtatc ctgcctaaag 351961 aaagaggaga acacatcaaa aatcacttgg acaaacactt tgaaatgatg aaacaaaacg 352021 gctttgttcc aaagcaccat cctcatccgc ataaatttga aaaaagacat taagatttta 352081 agcatccaat gggaattggg tgcttttgcg ttatttacag gtaggcaata ttagctgagc 352141 tgttccgcga ctaacatcga gttgatatga aacgcgtttc atagcctatg ataggtttat 352201 caaataattc aggagtgata aacactatga tccaccagca tccagaatct tttccgaaac 352261 attttttgtg gggctctgct tctgcagcgt accagattga aggcgcttgg aatgaagatg 352321 gcaaaggccc ttctgtttgg gatgtgttta cgaaaatacc gggcaaaacg tttaaaggaa 352381 ccaatggcga gattgcggtt gaccattatc accgatttaa agaagatgtc gctctgatgg 352441 ctgagatggg gttaaaagca tatcgatttt ccgtcagctg gccacgggtt tttccaaaag 352501 gaaaaggaga gatcaatgaa gcaggtctag cgttttacga tagtctgatt gatgaattgc 352561 tttctcatca catcgagccg gttctgactt tatatcactg ggatttgcct caagcgctta 352621 tggacgaata cggcgggttt gaatccagaa acatcataga ggattttaat cactactgta 352681 ttactcttta taaacgtttt ggagacaggg tgaaatattg ggttacgtta aacgaacaga 352741 actacaattt taatcacgga tttattacag ccatgcatcc gcctggagtg aaagacagaa 352801 aacgatttta cgaagcaaac catattgcgt ttctggctaa tgcaaaagcc atcgaatcat 352861 ttagagaata tgtgcctgaa ggcaaaatag gtcctagctt tgcttattct ccggcttacc 352921 ctttatcaag tcatccagag gatatactgg catttgaaaa cgccgaagaa tttacgaaca 352981 attggtggct tgacatgtat tgctggggaa cctacccgca aattccattc cgctgcttgg 353041 aaaaacaggg atgggcgccg acaattgaag caggagatat ggacctgctc gccaaaggga 353101 agcctgattt tgtaggtgtc aattattatc agacgatcac ctatgaacga aatccgcttg 353161 atggtgtgtc agaagggaaa atgaatacga caggccaaaa gggaaccaat caggagacgg 353221 ggatacccgg agtgttcaaa acgaaaaaaa atccgcatct gacaacgagc aactgggatt 353281 ggacaattga cccaattggg ctgcgtatcg gtcttcgccg aattacaagc cgctatcagc 353341 ttccagtgtt tataacagag aacggtttgg gtgaatttga taaagttgag gacggcactg 353401 tacaggatga ttatcgaatt gattatttgc gttcgcatct tgagcaatgc agacaagcca 353461 tcagtgacgg tgtcgattta atcggctatt gcagctggtc gtttactgat ctgttaagct 353521 ggctgaacgg ctaccaaaaa agatacggat ttgtatatgt caatcgtgat gaagaaagca 353581 catccgattt aaaacgcttg aagaaaaaaa gcttttattg gtatcaagat gtcatcaaga 353641 caaacggaga aagtttataa agagtccctg agagttattc tctcaggggt ttttcattac 353701 acagaaacag catcaataat ataagtgtcg gcgtgcaaat ctgacatttc agccggcaca 353761 gtccagcatg tcaattgata gtctccttta ggcagatcaa aggacagtct tttagacatg 353821 atgctttcaa tatgaattcc gttttctgtg acatgaaaag gaacagtcac ttttttttcg 353881 taggagttta ctgtttctga actgttcagg cgaaaaagaa taaaggcctt tgtatttcgc 353941 tgtgcctcaa aggaaatggc tccgtctgcc gcagcatatc ctttttcaat cgcttcgtca 354001 gtccaatcca ttacaggagg tgtagaatcc ttttgaaata cagtaaattg atgatatgaa 354061 atcgaaagtt cttgcggctt ccatgatttg atcaatgtgc tgttcctcct ctatgtactg 354121 tttactgaat tgtgaataaa acctttgtgc cgtctgggta atcggtaagc cgatgcccga 354181 cccaagagcc tgctccgcgg ttgtcagcgg gagaaatgta ttctacagaa gctccctcac 354241 cgccttcttt gcacatggcc attggccatt catctctgtc ataccccttt ttggaaggta 354301 cgtcctttaa tgattgctcg cggcgttctt cagctccgtc tctgtcaata gtgcacacct 354361 ctgagtgccc ctcatttatc gcatccttaa tatgcttggc agtttcggga taccggtcag 354421 atgggaaggc cattgtttca tcatattctt tcgtttgaga cgttttttga tcagctgaga 354481 aaaagtctcc ttttatcagg ccgacagctg cagctgctat gatgacgatg acgagaagta 354541 tcgtttttat gatgtccgtc gtgatgttca cctcccgctt ttaaaactga cacaagagta 354601 atccagaaag catttggtgt aaaggtttaa attttatgtt ttacgatcag tttattgcag 354661 aaatcgtaat tttagcagat cgaaatattt gttttcagca aaatacgatt gccaatttac 354721 aataatgata gtaagtcatc agccgttttc ggcttgatta atcattttaa attggcttat 354781 gataccggta agctcctcag ctaattgaga aagtgtttca gaagctgcgg taatctcctc 354841 cattgcagca aattgctcct ctgttaatgc agccgcttgc cgggtatttt tagtagattc 354901 tttaatgtcg gccgtattgg ctgcaaagga atcatttatt tgatgtgcac tggctgaaat 354961 gtttgttaca gatgctgata aatcactaat ctcggcgctg atttcacctg ttgcagctgc 355021 aatttcctta aatgcatctc tggtgcgctg gatcatggtg actccttctg cagcttctgt 355081 tttcacatgc tcaacagatc ttgcagaccg gttcatatcc ttttgtattt ctatgatcag 355141 ttttgaaatc tgccccgcag actgttgaga ctcttctgct aatttccgta cttcatcagc 355201 aacaacagca aagccttttc cttgttcacc ggctctggca gcttcaatcg ctgcattcag 355261 cgcaagcagg tttgtctgat cagcaatttg ggtgatgacc gataaaattt gctcaatttg 355321 tttagagcgg ccgtctaact ggtgtatgat ttctccgctt ttctgaattg actggtgaat 355381 cgcatccatt tgcgcctgta catttgcaat ttccttttgt ccaatgtctg cttttgattg 355441 agcgagctgc cctttgtcag cgatagcggc agtatttgca gaaatatccc ggatgtctgc 355501 tgaagcttgt tttaatgagc tttcactatt ttcaattcgg gtgatctgat cttgggctcc 355561 atttgcaatc tgctgtacag cttctgtgat tttttctgaa gcttgatttg tttcctctgc 355621 tccggctgag agctgctgag aggctgacgc aagctgaagg gctgattgtt gtacggtttg 355681 tatggtatcg ttcagcttca ttctcatctt attataatag acgcttagtt ctgaaagctc 355741 gtcaccggtt ttgtctgaca cctctattgt catatctccg tttccggcac tttcaaaggc 355801 gctttttaaa gcgttcagcc gcttgttgat ttttctggtg aaaaccaaga caaggatgac 355861 tgataccata atgacgataa caagaacgat agcgaattga gtgaaaagtg attgtgtaag 355921 tgatgctaaa atactttgat tagctccggt atacagcatg ccgatgatgt tcccattttg 355981 atcttttaac ggcatgtatg cagtctgata agaagaacct gctacatctg cttgtccgta 356041 aaaacgcttt cctttcttta aaacagcggc aataacttca gaagaagcct gggtgccgac 356101 ggctctttcg ccatttttca tgacattggt tgcaacacga gtatcgcctt ggaaaatggt 356161 aatggtatca cctgtctttt caccaagcag atcaacaata tcttcatttc cattgatttg 356221 tgtttgccct ttatagagct tattgttttt cacctgccag tcgcctgaca tgacatcatc 356281 aatataagtg ctgcttaaag cgagatcacc tttcgctttt tcagttgcca tttgtttcat 356341 gctttctgta atttccttaa gcatcacagt gccaactgat gccgaaaaca aaagaatcac 356401 cacgaaaacg aggcaaagaa ttttagttcc tagcttcatc ttaaatcgtt ttatcaacat 356461 aattcctccc tttacgattt gcaggtcata ttacttatcg ggtttttggg tttaaagttt 356521 tattttagaa aaaataaaac cggcctgatc ttcaggccgg ttgtgtgatg ctattcaagg 356581 tttgcgtggt gagtgaacat agtttcagaa tcgagacctt ttttctccat gagttttaaa 356641 atcactgcat catagaagag cagcaaagtt tgttcaaata atgatcccat tggctgaatg 356701 gttttatagc ttccgttaga ctggtcttta ggggaaccag gcattctgat gatgaggtcc 356761 gcttgttttc cgatgcttga ttccggattg atggttaaag cggcaacaat tccgtgtaag 356821 ctttttgctt ttgctgcggt atgaatcaag ctctttgtct cgcctgatcc tgagccgata 356881 ataactagat ctccttcggc gagcggcgga gtgagaatct cacctactat atgggcgttg 356941 aagcccatgt gcatcagtct catcgcgaag gattttgcca tcaggccaga ccgccccgca 357001 cccgcggtga aaatttggtg ggatgaaaga atgtgatcgg caagctggtc agcttcttca 357061 ttagaaatat aagctgctga attgtgtaac tcattgagaa tttccgctac gtattcagtc 357121 gttttcatcg gagttatcct tggacaatca gctgcttcat ttttgaagct gtttccgcct 357181 tatcagctgc gcttgtaatt ccgcccccga caatgacaag gtcaggcttt tgctggatca 357241 cttctggcag tgtatcaagt ttgatgccgc ccgcgattgc ggtttttgcg ttttttacgg 357301 tatttttgat tgtcgttaat tcttcgaaag agtttttgcc ctctgcttga agatcatagc 357361 cagtgtggac gcagatgtag tcaacaccga gtgcgtcaat ttctttcgca cgggattcga 357421 tatctttcac gttaatcatg tccactaaga ttttcttctt ttgttttttg gcttcttcta 357481 ctgcgccttt aatcgttgca tcgtctgtag cccctaaaac ggtgatgatg tcagcgcctg 357541 cttccgacgc tttcataatt tcgtagcctc cggcatccat gattttcagg tctgcaagaa 357601 ccttcaattg aggaaatgct tcttttattt ctttaacggc tcttaggcct tcattgatga 357661 cgaccggtgt tccgatttca actacgtcga tgtattgttc tacctctttg acaagctcaa 357721 tggcttccgg gatgttgacg aggtctaatg caagctgtaa ttccattgtt gatccactcc 357781 ctttttcgaa ttattgttca ttctataggt tccttctttt gttgagaagt aggcactttg 357841 aagtcaacaa gttacttgga ggatactgtg aggagagaca atcagatttc tttcgcttga 357901 ttttatgagt gagtataatg aaaaaagagt ctgcaaaaaa gtaagtaagt gatgatacgt 357961 atctaacata caaaaaggtt actaaggggg gggattctat tgagccggat ggacgacaaa 358021 aggtttaatt gtgagaagga attaacgctt gcagtgattg gcggtaaatg gaaaatgctc 358081 attttatggc atttaggaaa agaaggcaca aaacggttca atgaattaaa aacattgatt 358141 cctgatatta cgcagaagat cctcgtgaat cagctgagag agcttgagca ggatatgatt 358201 gttcacaggg aagtgtatcc agttgtcccg ccgaaggttg aatattctct gaccccgcac 358261 ggagaaagcc tcatgcctat tcttgaagcc atgtatgagt gggggaaagg ctatatggaa 358321 ttgattgata tcgacaaaaa tgtcatgaaa gaatcgttgt aagacgctct tcgcaagggt 358381 gtcttttttt gccttttttt cggtttttgc gcggtacaca tagtcatgta aagattgtaa 358441 attgcattca gcaataaaaa aagattgaac gcagcagttt ggtttaaaaa tttttatttt 358501 tctgtaaata atgtttagtg gaaatgattg cggcatcccg caaaaaatat tgctgtaaat 358561 aaactggaat ctttcggcat cccgcatgaa acttttcacc catttttcgg tgataaaaac 358621 atttttttca tttaaactga acggtagaaa gataaaaaat attgaaaaca atgaataaat 358681 agccaaaatt ggtttcttat tagggtgggg tcttgcggtc tttatccgct tatgttaaac 358741 gccgcaatgc tgactgacgg cagcctgctt taatagcggc catctgtttt ttgattggaa 358801 gcactgcttt ttaagtgtag tactttgggc tatttcggct gttagttcat aagaattaaa 358861 agctgatatg gataagaaag agaaaatgcg ttgcacatgt tcactgctta taaagattag 358921 gggaggtatg acaatatgga aataactttt taccctttaa cggatgcaca aaaacgaatt 358981 tggtacacag aaaaatttta tcctcacacg agcatttcaa atcttgcggg gattggtaag 359041 ctggtttcag ctgatgcgat tgattatgtg cttgttgagc aggcgattca agagtttatt 359101 cgcagaaatg acgccatgcg ccttcggttg cggctagatg aaaacgggga gcctgttcaa 359161 tatattagcg agtatcggcc tgttgatata aaacatactg acactactga agatccgaat 359221 gcgatagagt ttatttcaca atggagccgg gaggaaacga agaaaccttt gccgctatac 359281 gattgtgatt tgttccgttt ttccttgttc accataaagg aaaatgaagt gtggttttac 359341 gcaaatgttc atcacgtgat ttctgatggt atctccatga atattctcgg gaatgcgatc 359401 atgcacattt atttagaatt agccagcggc tcagagacaa aagaaggaat ctcgcattca 359461 tttatcgatc atgttttatc tgaacaggaa tatgctcaat cgaagcggtt tgaaaaggac 359521 aaggcgtttt ggaacaaaca atttgaatcg gtgcctgaac ttgtttcctt gaaacggaat 359581 gcatccgcag ggggaagttt agatgctgag aggttctcta aagatgtgcc tgaagcgctt 359641 catcagcaga ttctgtcgtt ttgtgaggcg aataaagtca gtgttctttc ggtatttcaa 359701 tcgctgctcg ccgcctattt gtacagggtc agcggccaga atgatgttgt gacgggaaca 359761 tttatgggca accggacaaa tgcgaaagag aagcagatgc ttggcatgtt tgtttctacg 359821 gttccgcttc ggacaaacat tgacggcggg caggcgtttt cagaatttgt caaagaccgg 359881 atgaaggatc tgatgaagac acttcgccac caaaagtatc cgtataatct cctaatcaac 359941 gatttgcgtg aaacaaagag ctctctgacc aagctgttca cggtttctct tgaatatcaa 360001 gtgatgcagt ggcagaaaga agaggatctt gcctttttga ctgagccgat tttcagcggc 360061 agcggattaa atgatgtctc aattcatgta aaggatcgat gggatactgg gaaactcacc 360121 atagattttg attaccgcac tgatttattt tcacgtgaag aaatcaacat gatttgtgag 360181 cgcatgatta ccatgctgga gaacgcgtta acgcatccag aacatacaat tgatgaatta 360241 acactgattt ctgatgcgga gaaagagaag ctgcttgcga gggccggcgg taaatctgtg 360301 agctaccgta aggacatgac gataccagag ctgttccaag aaaaggctga actgctttct 360361 gatcatccag cggttgtatt tgaagatcgc acattgtcct atcgaacgtt acatgagcaa 360421 tctgcacgca tcgccaatgt gctgaaacag aaaggggttg gcccggacag tcctgtcgcg 360481 gttttgattg aacgctctga acggatgatt acagctatca tgggaatttt aaaagccggc 360541 ggagcctatg tgccgattga tccgggtttt cctgctgagc gcattcaata tattttggag 360601 gactgcgggg cggatttcat cctgactgaa tcgaaggttg cggcgcctga agccgatgct 360661 gagctgattg acttagatca ggcgattgag gaaggtgcag aagaaagcct gaatgcagat 360721 gtgaacgctc ggaaccttgc ctacattatt tacacatcgg gaacaaccgg acgcccgaaa 360781 ggcgttatga tcgagcatcg ccaggttcat catttggttg aatctctgca gcagacgatt 360841 tatcaaagcg gcagccaaac cctgcggatg gcattgcttg cgccgttcca ctttgatgcg 360901 tcagtgaagc agatcttcgc gtcgcttctt ttgggccaaa ccctttatat cgtaccgaag 360961 aaaacagtga cgaacggggc cgcccttact gcatattatc ggaagaacag cattgaggcg 361021 acggacggaa caccggctca tttgcaaatg ctggcagcag caggcgattt tgaaggccta 361081 aaactgaagc acatgctgat cggaggagaa ggcctgtcat ctgttgttgc ggacaagctg 361141 ctgaagctgt ttaaagaagc cggcacagcg ccgcgtttga ctaatgtgta cgggccgact 361201 gaaacgtgcg ttgacgcgtc tgttcatccg gttatccctg agaatgcagt tcaatcagcg 361261 tatgtgccga tcgggaaagc gctggggaat aaccgcttat atattttgga tcaaaaaggc 361321 cggctgcagc ctgaaggcgt ggcgggtgag ctttatatcg cgggagacgg tgtgggccga 361381 ggctatttac atttgcctga attaacggaa gagaagtttt tacaagatcc attcgtgccg 361441 ggcgatcgca tgtaccggac cggggacgtg gtgcgctggc ttccagatgg aacaatcgaa 361501 tatttaggca gagaggatga ccaggtcaaa gtccgcggat accggattga gcttggggaa 361561 attgaagccg tgattcagca ggcgccagac gttgcaaaag ccgttgtttt ggcacgccct 361621 gacgaacagg gaaatcttga ggtttgcgca tatgttgtgc agaagcctgg aagcgaattt 361681 gcgccagccg gtttgaggga gcatgcggcc agacagcttc ctgactatat ggtgccggct 361741 tactttacag aagtgacaga aattccgctt acaccaagcg gcaaagtcga ccgccgcaag 361801 ctgtttgcac tagaggtgaa ggctgtcagc ggcactgcct atacagcgcc gcgaaatgag 361861 actgaaaaag caatcgcagc catttggcag gacgtgctga acgttgagaa ggcggggatc 361921 tttgacaatt tctttgaaac tggcggacat tcattaaaag ccatgaccct tttaacaaag 361981 attcataagg aaacaggcat tgagattccg cttcaatttt tgtttgagca tccgacgatt 362041 acggctcttg cagaggaagc tgatcacaga gaaagcaaag cttttgcggt gattgaacct 362101 gctgaaaaac aggagcatta cccgctttca ttggcacagc agcgaacata tatcgtcagc 362161 cagttcgagg atgcgggagt cggctataac atgccagcag cagcaattct ggaagggcct 362221 ttagatattc aaaagctgga gcgcgcattt cagggattaa tccgacgcca cgagtcattg 362281 agaacatcat ttgttcttga aaacagcacg ccgagacaga aaattcacga tagcgttgat 362341 ttcaacatcg aaatgattga aagaggcggc cgctcagatg aggcaattat ggcttcattc 362401 gttcggacat ttgatttggc gaaagctccg ctgttcagaa tcggtttgct ggggcttgaa 362461 gagaaccgtc atatgctgct gtttgacatg caccatttga tttctgacgg tgtatccatt 362521 ggcattatgc tggaggagtt agcacgcatt tataaaggcg aacagcttcc tgatcttcgt 362581 ctccagtata aggactacgc tgtatggcaa agcagacagg ctgctgaagg gtacaagaag 362641 gaccaggctt attggaagga agtctttgca ggcgagctcc cggtgcttca gcttctgtcc 362701 gattacccaa gaccacctgt tcaaagcttt gaaggggatc gggtgtcaat caagctggat 362761 gcgggggtaa aggatcgcct caatcgtttg gctgaacaaa acggcgccac tttatatatg 362821 gtgatgcttt ccgcttacta tacgcttttg tcaaagtata cggggcagga tgacatcatt 362881 gtcgggacac cgtcagcggg cagaaatcac tccgatacag agggcattat cgggatgttc 362941 gtcaatacgc ttgcgattcg cagtgaggtg aagcagaatg agacgtttac ccaattgatc 363001 tcgcgtgtcc gcaaacgggt gctggatgcc ttttctcatc aggactatcc gtttgagtgg 363061 cttgttgaag atttgaacat cccgcgtgat gttagcaggc atccgctgtt tgacacgatg 363121 ttcagccttc aaaacgcgac agagggcatt ccggctgtcg gcgatctttc cttgtctgtt 363181 caagagacca atttcaagat tgccaaattt gatttgacgg tgcaggcgag agaaaccgat 363241 gaaggcattg agattgatgt ggattacagc acaaagctgt ttaaacaaag cacggcagac 363301 aggctgctta cgcattttgc gcgtttgctt gaagatgctg cggctgatcc agagaagccg 363361 atttctgagt ataagcttct ttctgaagag gaggctgctt cgcaaattca gcagtttaac 363421 ccgggcagaa caccttatcc gaaagataaa acaattgttc agctgtttga ggagcaagcg 363481 gcgaatacgc cagaccacac tgcgcttcaa tatgaaggcg aatcactcac ttatcgtgaa 363541 ctgaatgaac gggccaatcg tttagcccgc ggcattcttt ctcttggagc tggcgaaggc 363601 agaactgcgg ctgtcttatg cgagcggtca atggatatga ttgtgtcgat cttggcagta 363661 ttaaaatcag gttcggctta tgttccgatc gatccggaac atccgattca gcggatgcag 363721 catttcttcc gtgacagcgg agcaaaggtg cttctcactc agaggaaatt aaaggctttg 363781 gcggaagaag cggaatttaa gggcgttatc gtgctagccg atgaggaaga aagctatcat 363841 gccgatgcgc gaaatctcgc actgcctctt gattctgcag caatggccaa cctgacgtat 363901 acttccggaa cgactggaac acctaagggg aatatcgtga cacatgccaa tattctccgc 363961 acggtgaagg aaacgaatta tctcagcatt acagaacagg atacgattct cggtctttcc 364021 aattacgtgt ttgacgcgtt tatgttcgat atgttcggct ctttgttaaa cggagccaag 364081 ctggtgctga taccgaagga aaccgttttg gacatggctc gcctgtcccg cgtcattgaa 364141 cgggagaaca tcagcattct catgattaca accgctttgt tccacttgct tgtggacttg 364201 aatccggcat gcttgtcaac gcttcgcaag attatgtttg gcggggaacg ggcttcggtt 364261 gagcatgtca gaaaagcttt gcaaacggtt ggaaagggca agctccttca tatgtatgga 364321 ccgtctgaaa gcacggtttt cgcgacgtat catccggttg atgaattgga ggagcacacg 364381 ctgtctgttc cgattggaaa accggtcagc aatacggaag tatacattct tgaccgtacg 364441 ggacacgtgc agcctgccgg gattgccgga gagctttgcg tcagcggcga aggactcgtg 364501 aaaggctatt acaaccgtcc agaactgact gaggagaaat ttgttcccca tccgtttaca 364561 tccggcgaac gcatgtataa aacgggagac cttgcgagat ggctgccgaa tggcgacatc 364621 gaatttatcg ggcgaatcga ccatcaggtg aagattcgcg gacagcgcat cgagcttgga 364681 gaaatcgaac atcagctgca aacccatgat cgtgttcagg aaagtgttgt gcttgccgtt 364741 gatcaaggag cgggagataa actgttgtgt gcttactatg tcggagaagg agacatctca 364801 tcacaagaga tgagagagca tgctgcgaag gacttgccgg catatatggt tcctgcggtg 364861 tttatccaaa tggacgagct gccgctgaca gggaacggaa aaattgaccg gagagcgctg 364921 ccgattcctg atgccaacgt ttcaagaggt gtttcatatg ttgcgccacg caatggaacg 364981 gaacaaaaag tcgcggacat ttgggcacag gtacttcagg cagaacaagt cggcgcttat 365041 gaccacttct ttgacattgg cggacattca ttagcaggca tgaagatgct tgccttggtt 365101 catcaggaac tgggcgttga gctgtcactc aaggatctct tccagtcacc gacggttgag 365161 ggcttggcac aggtgattgc ctctgctgaa aaagggacag ccgcaagtat cagcccggca 365221 gagaaacaag atacgtatcc tgtttcttca ccgcaaaaac ggatgtacgt gcttcagcag 365281 cttgaggatg cgcaaacgag ctataacatg ccggcggttc tgcgcctgac aggtgagctt 365341 gatgttgaaa ggcttaacag cgtcatgcag cagttaatgc agcgtcatga agccttgaga 365401 accacgtttg aaataaaaga tggagaaacg gtgcagcgga tctgggaaga ggctgagtgc 365461 gagatagcct atttcgaagc cccggaagaa gagacagagc ggatcgtttc tgagtttatt 365521 aagcctttca aaatcgacca acttccactg ttcagaatag ggcttatcaa gcattcagac 365581 actgagcatg tgctgctgtt cgatatgcat catattattt ctgatggtgc atctgtcggt 365641 gtgctgattg aggagctttc aaagctgtac gacggagaaa cccttgagcc gctccgtatt 365701 caatataagg attatgccgt gtggcagcag cagttcattc agtctgagct ttacaagaag 365761 caagaagagc attggctgaa ggagctggac ggagagctgc cggtgctgac gcttccgact 365821 gattacagtc ggcctgccgt tcaaacattt gagggagacc gcattgcatt ttcattagaa 365881 gcaggcaaag ctgatgctct gcgcaggctt gcaaaagaaa cggattccac gctttacatg 365941 gtgcttctgg cttcatacag tgcgttttta tcaaaaatta gcgggcaaga cgatatcatc 366001 gtcggttcac ctgtggccgg acgatctcaa gcggacgtca gccgcgtcat cggaatgttc 366061 gtcaatacat tggcgctgcg cacgtatccg aagggtgaaa agacgtttgc tgactatctt 366121 aacgaagtga aagaaacggc actcagcgct tttgatgcgc aggattaccc acttgaggat 366181 ttgatcggaa atgttcaggt tcagcgtgac acaagcagaa atccgttatt cgatgcagtt 366241 ttttcaatgc aaaatgcgaa tataaaggat ttaacaatga aagggattca gcttgagccg 366301 catccgtttg aacggaaaac agccaagttt gacctcacgc tgacggctga cgaaaccgac 366361 ggagggctta cattcgtact cgaatacaat acagctctgt ttaagcagga aacgattgaa 366421 cgatggaagc aatattggat ggagctttta gatgcagtta ctgggaaccc gaaccagccg 366481 ctttccagcc tgtcactggt caccgagaca gaaaagcaag cgcttcttga ggcatggaag 366541 ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga agagactgcc 366601 cagcgccaca aagaccgccc ggctgtcaca tacaacggcc agtcttggac gtacggcgag 366661 ctgaatgcga aggcaaaccg tctcgcgcgg attctgatgg actgcggcat cagcccggat 366721 gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt gctcggcgtc 366781 ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact atccggatca gcggattgag 366841 tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat ttcagtgccg 366901 gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct aagcctgccg 366961 cttgatgaaa acgacgagga aaatccagaa accgctgtaa ccgcggagaa cttggcgtac 367021 atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga gcaccatgcg 367081 cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga ggaccgcagt 367141 gcgaagtacg cgggctttgg gttcgacgct tccatttggg agatgttccc gacctggacg 367201 atcggtgccg aacttcacgt cattgaggaa gcgatccgcc tcgatatcgt ccgcctgaac 367261 gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct tgcggaacag 367321 ttcatggagc ttgagaacac atcacttcgc gtattgctta ctggaggaga caagctgaag 367381 cgcgcagtga aaaagccgta cacactcgtc aataactacg ggccgacaga gaatacggtc 367441 gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg aagggccatt 367501 gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga aggcgtagcc 367561 ggagagcttt gcgtggcggg gcgcggactg gcacgcggct atctgaatcg agaagacgaa 367621 accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg agcgcatgta ccgcaccggc 367681 gatttggtga aatggacggg cggcggcatc gaatacatcg gccggatcga ccagcaggtc 367741 aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc ccagctttct 367801 gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaacac agcgatcgcg 367861 gcgtatgtca caccggaatc agctgacata gaagcactga aatcagcact gaaggaaacc 367921 ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc ggttacggca 367981 aacggcaaag tggaccgcaa agccttgcct gagccggaca tcgaagcggg aagcggagaa 368041 tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca ggacgtgctt 368101 ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga ttccatcaaa 368161 ggaattcaaa tggcgagccg cttgaaccag cacggctgga agctggaaat gaaagatctc 368221 ttccagcacc cgacgatcga agagctcacc cagtacgtag agcgtgccga aggcaaacag 368281 gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg ctggttcttt 368341 gaaaagaact tcacgaacaa gcaccactgg aaccaatctg tgatgcttca cgccaagaag 368401 ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca tcatgacgcg 368461 ctccgcatgg tctatcgtga gggacaggaa gacgtcattc aatacaacag aggtcttgaa 368521 gctgcttcag ctcaattgga ggtcatccag attgagggcc aagctgcaga ttacgaagac 368581 cgaatagaga gagaagcgga gcgtttgcaa agcagcatcg acttgcagga aggcggcttg 368641 ttaaaagcag gcttgttcca agcggaagac ggagatcact tgcttcttgc cattcaccac 368701 ttagtggttg acggcgtgtc gtggcggatt ttactggagg atttcgccgc ggtatataca 368761 cagcttgagc aaggcaatga accggttctc ccgcagaaaa cacattcatt tgcagagtat 368821 gcagagagat tgcaagactt cgcgaactcc aaagcctttt tgaaagaaaa agagtattgg 368881 agacagcttg aagaacaagc tgttgcggca aagcttccga aagaccgcga atctggtgat 368941 cagcgaatga aacatacaaa gacaattgaa ttctcgctga ctgctgaaga gacagaacag 369001 ctcaccacaa aggtgcatga ggcatatcac acagaaatga atgatatttt gctgacggca 369061 ttcggattgg caatgaagga gtggacgggt caagatcgag taagtgttca tttagagggg 369121 catggacgtg aagaaatcat agaagacctg accatttctc gcacagtcgg ctggtttaca 369181 agtatgtacc caatggtgct cgatatgaag catgcggatg atctgggcta ccagctgaag 369241 caaatgaaag aagatatcag acatgtgccg aataagggag tcggatacgg cattctgcgc 369301 tatctgacgg caccggaaca taaagaagat gtggcgttct cgattcagcc ggatgtcagc 369361 ttcaactatt taggtcagtt tgacgaaatg tcggatgcag gtttgtttac gagatcagag 369421 ctgccatcag gacagtcatt aagccctgaa acagaaaaac cgaatgcgct ggatgttgtc 369481 ggatatatcg aaaacggaaa actgacgatg tcactggcct atcattctct tgaatttcat 369541 gaaaaaacag tacaaacatt cagtgacagc tttaaagcgc atcttctcag aatcattgaa 369601 cattgcctat ctcaagatgg tacggaactg accccgagtg atcttggtga cgacgatttg 369661 acgctggatg agctggataa attaatggaa attttctaat agaggtggca tatgagcaaa 369721 aaatcgattc aaaaggtgta cgcactgaca ccaatgcagg agggaatgct gtatcatgcg 369781 atgcttgatc cgcattcttc ctcgtacttc acacaattag agcttgggat tcacggcgct 369841 tttgatcttg aaatctttga gaaaagcgtc aatgaactga ttcggtcata cgatattctc 369901 cgtacggtat ttgtgcatca gcagctgcaa aaaccgcgtc aggtcgtgtt agcggaacgc 369961 aaaacaaaag tgcattatga ggatatcagt catgcagacg aaaaccgcca gaaagagcac 370021 attgagcgtt acaaacaaga cgttcagcgc caaggcttta acctggcaaa agacatattg 370081 ttcaaggtag cggttttccg ccttgctgca gatcagctgt atcttgtctg gagcaatcat 370141 catattatga tggacggctg gagcatgggc gtcctcatga aaagcctgtt ccaaaactat 370201 gaagcgctca gagcaggcag gacaccggca aacggtcagg gcaagcctta ttccgattac 370261 atcaagtggc ttggaaaaca ggacaatgaa gaagcggaga gctactggag cgagcgcttg 370321 gcgggttttg aacagccaag cgtgctcccg ggccgcctgc ctgtgaaaaa agacgaatac 370381 gtcaataaag aatattcatt tacatgggac gaaacactgg ttgcccgtat tcagcaaacc 370441 gcaaatctcc atcaagtgac agggcctaac ctatttcagg ccgtttgggg cattgttctc 370501 agcaaataca actttacgga tgatgtgatc ttcggaacgg tcgtctcggg acgaccgtct 370561 gaaatcaacg gaatcgaaac gatggcgggg ctgtttatca acaccattcc agtgcgggtg 370621 aaagttgaac gagatgctgc attcgctgat attttcacag ctgttcagca gcatgcagta 370681 gaggcagagc gttacgatta cgtgccgctc tatgagattc aaaaacgctc agctcttgat 370741 ggcaatctct taaaccatct ggtcgcgttt gaaaattatc cgcttgatca agagcttgaa 370801 aacggcagca tggaagaccg cctcgggttt tcgattaagg tagaaagcgc atttgaacaa 370861 acgagcttcg atttcaacct gattgtgtat ccgggcaaaa cgtggaccgt caaaattaaa 370921 tataacggag ccgcctttga ttccgctttt atcgaacgga cagcggagca ccttacccgc 370981 atgatggaag cagctgtcga tcagccggcc gcttttgtgc gtgagtacgg gcttgtggga 371041 gacgaagagc agcggcaaat tgtcgaggtg tttaacagca cgaaagccga actccctgaa 371101 ggaatggctg ttcaccaagt gtttgaagag caagcgaaac ggacgccggc gagcaccgcc 371161 gtcgtatatg aaggaaccaa gctgacgtac cgcgagctga atgcagcggc taaccgtctg 371221 gcgagaaagc ttgtcgaaca tgggcttcaa aaaggggaaa cagcagcgat tatgaacgac 371281 cgctcagtag aaaccgttgt cggcatgctg gctgttttaa aagcaggcgc cgcatatgtg 371341 ccgcttgatc cagcgcttcc tggggatcgt cttcgtttca tggcagagga cagctccgtt 371401 cgaatggttt tgatcggaaa ttcttataca gggcaggcac atcagctgca agtgccggtt 371461 cttacactgg acataggctt tgaagagagt gaagcggctg acaatctcaa cctgccatcc 371521 gccccgtctg atttggcgta catcatgtac acatccggtt caacgggcaa accgaaaggc 371581 gtcatgatcg aacataaaag cattctgcgc ctcgtcaaaa atgccgggta cgttcctgtt 371641 actgaagaag accgcatggc gcaaacggga gctgtcagct ttgatgccgg aacgtttgag 371701 gtattcggcg cactgctgaa tggcgcagca ctttatccgg tcaaaaaaga gacactgctt 371761 gatgcgaaac aatttgctgc attcctgcgt gagcaaagca tcacaactat gtggctgaca 371821 tcacctttat tcaaccagct tgctgcaaag gatgcgggta tgttcggcac actgcgccat 371881 ttaatcatcg gcggagatgc ccttgtcccg catattgtca gcaaagtaaa acaggcatcg 371941 ccgtcgcttt cattgtggaa cggatacggc ccgacagaaa acacgacgtt ttcaaccagt 372001 tttctgatcg accgcgagta tggcggctct atcccaatcg ggaagccgat cggaaattcc 372061 actgcctata ttatggatga gcagcaatgc ctgcagccaa tcggcgcgcc tggtgagctt 372121 tgcgtaggcg gaatcggtgt agcgcgtggg tatgtcaatc tccctgagct gacggagaag 372181 caatttctgg aagacccgtt cagaccgggt gagagaattt accgcactgg tgacttggca 372241 agatggctgc cggacggcaa tatcgaattt ttaggcagaa tcgacaacca agtgaaggtg 372301 cgcggcttcc gaattgagct tggcgaaatt gaaacaaaac tgaacatggc tgagcatgtg 372361 acagaagccg cggtgatcat acgcaagaac aaagcagacg aaaatgaaat ttgcgcgtac 372421 ttcacggcgg atcgtgaagt ggctgtgagt gagctgagaa aaacactgtc tcagtctttg 372481 cctgactata tggtccctgc ccacctgatt caaatggaca gcctgccgct cacgccaaac 372541 gggaaaatca acaaaaagga actgcctgca ccgcaatcag aagccgtgca gccggaatac 372601 gcagcaccaa aaacagagag tgaaaagaaa ttagcggaga tctgggaagg aatactcggc 372661 gtcaaagcag gcgttaccga taacttcttt atgatcggcg gccattcttt gaaagcgatg 372721 atgatgacgg cgaaaattca agagcatttt cataaggaag ttccgataaa agtgcttttt 372781 gaaaagccga ctattcaaga actggcactg tatttggaag agaacgaaag caaggaggag 372841 cagacgtttg aaccgatcag gcaagcatct tatcagcagc attatcctgt atccccggcc 372901 cagcggagaa tgtatatcct caatcagctt ggacaagcaa acacaagcta caacgtcccc 372961 gctgtacttc tgctggaggg agaagtagat aaagaccggc ttgaaaacgc gattcagcaa 373021 ttaatcaacc ggcacgaaat cctccgtaca tcgtttgaca tgatcgacgg agaggttgtg 373081 caaaccgttc ataaaaacat atcgttccag ctggaggctg ccaagggacg ggaagaagac 373141 gcggaagaga taatcaaagc atttgttcag ccgtttgaat taaaccgcgc gccgctcgtc 373201 cgttcgaagc ttgtccagct ggaagaaaaa cgccacctgc tgctcattga tatgcatcat 373261 attattactg acggaagttc aacaggcatt ctaatcggtg atcttgccaa aatatatcaa 373321 ggcgcagatc tggaactgcc acaaattcac tataaagatt acgcagtttg gcacaaagaa 373381 caaactaatt atcaaaaaga tgaggaatac tggctcgatg tctttaaagg cgaactgcca 373441 atactggatc ttcccgcgga tttcgagcgg ccagctgaac ggagctttgc gggagagcgc 373501 gtgatgtttg ggcttgataa gcaaatcacg gctcaaatca aatcgctcat ggcagaaaca 373561 gatacgacaa tgtacatgtt tttgctggcg gcgttcaatg tactcctttc caagtacgcg 373621 tcacaggatg atatcattgt cggctcgccg acagctggca gaacacatcc tgatctgcaa 373681 ggtgtgccgg gtatgtttgt caacacggtg gcactcagaa cggcaccagc gggagataaa 373741 accttcgcgc aattccttga agaggtcaaa acagccagcc ttcaagcatt cgagcaccag 373801 agctatccgc ttgaggagct gattgaaaag cttccgctta caagggatac aagcagaagt 373861 ccgctgttca gcgtgatgtt caacatgcag aatatggaga ttccttcatt aagattagga 373921 gatttgaaga tttcctcgta ttccatgctt catcatgttg cgaaatttga tctttccttg 373981 gaagcggtcg agcgtgaaga ggatatcggc ctaagctttg actatgcgac tgccttgttt 374041 aaggacgaga cgatccgccg ctggagccgc cactttgtca atatcatcaa agcggccgcg 374101 gctaatccga acgttcggct gtctgatgta gatctgcttt catctgcaga aacggctgct 374161 ttgctagaag aaagacatat gactcaaatt accgaagcaa cctttgcagc actttttgaa 374221 aaacaggccc agcaaacacc tgaccattct gcggtgaagg ctggcggaaa tctgttgacc 374281 tatcgcgagc ttgatgaaca ggcgaaccag ctggcgcatc atcttcgtgc ccaaggggca 374341 ggaaatgaag acatcgtcgc gattgttatg gaccggtcag ctgaagtcat ggtatccatt 374401 ctcggtgtca tgaaggcggg ggcagctttc cttccgattg atcctgatac acctgaagaa 374461 cgaatccgtt attcattaga ggacagcgga gcaaaatttg cggtcgtgaa tgaaagaaac 374521 atgacggcta ttgggcaata tgaagggata attgtcagcc ttgatgacgg taaatggaga 374581 aatgaaagca aggagcgccc atcatccatt tccgggtctc gcaatcttgc atacgtcatt 374641 tatacgtccg gtacgaccgg aaagccaaag ggcgtgcaga ttgagcatcg taatctgaca 374701 aactatgtct cttggtttag tgaagaggcg ggcctgacgg aaaatgataa gactgtattg 374761 ctttcatctt acgcatttga ccttggctat acgagcatgt tccctgtact tctgggcggg 374821 ggcgagctcc atatcgtcca gaaggaaacc tatacggcgc cggatgaaat agcgcactat 374881 atcaaggagc atgggatcac ttatatcaag ctgacaccgt ctctgttcca tacaatagtg 374941 aacaccgcca gttttgcaaa agatgcgaac tttgaatcct tgcgcttgat cgtcttggga 375001 ggagaaaaaa tcatcccgac tgatgttatc gccttccgta agatgtatgg acataccgaa 375061 tttatcaatc actacggccc gacagaagca acgatcggcg ccatcgccgg gcgggttgat 375121 ctgtatgagc cggatgcatt tgcgaaacgc ccgacaatcg gacgcccgat tgcgaatgcc 375181 ggtgcgcttg tcttaaatga agcattgaag cttgtgccgc ctggagcgag cggacagctc 375241 tatatcacgg gacaggggct cgcgagaggg tatctcaaca ggcctcagct gacagccgag 375301 agatttgtag aaaatccata ttcgccggga agcctcatgt acaaaaccgg agatgtcgta 375361 cgaagacttt ctgacggtac gcttgcattt atcggccggg ctgatgatca ggtgaaaatc 375421 cgaggctacc gcattgagcc gaaagaaatt gaaacggtca tgctcagcct cagcggaatt 375481 caagaagcgg ttgtactagc ggtttccgag ggcggtcttc aagagctttg cgcgtattat 375541 acgtcggatc aagatattga aaaagcagag ctccggtacc agctttccct aacactgccg 375601 tctcatatga ttcctgcttt ctttgtgcag gttgacgcga ttccgctgac ggcaaacgga 375661 aaaaccgaca gaaacgctct gccgaagcct aacgcggcac aatccggagg caaggccttg 375721 gccgcaccgg agacagcgct tgaagaaagt ttatgccgca tttggcagaa aacgcttggc 375781 atagaagcca tcggcattga tgacaatttt ttcgatttag gcggccattc attaaaaggg 375841 atgatgctga ttgccaacat tcaggcggaa ttggagaaaa gcgtaccgct taaagcactg 375901 ttcgagcagc cgacagttcg ccagctggcg gcttatatgg aggcgtctgc tgtttcaggc 375961 ggccatcaag tactcaaacc ggctgacaag caggatatgt atccattgtc atccgcacag 376021 aaacgaatgt acgtgctcaa tcagcttgac cgccagacga taagctacaa catgccatct 376081 gttcttctaa tggaaggaga gcttgatatt tcgcgcctgc gcgactcact caatcagctt 376141 gtgaaccgtc acgaatcatt gcggacgtca tttatggaag ctaatggtga gcctgttcag 376201 cgcatcattg agaaggcgga ggttgatctt catgtgtttg aagccaaaga agacgaagcg 376261 gaccaaaaga ttaaggaatt tatccggcca ttcgacttaa acgacgcacc gctcattcgc 376321 gcagctttgc ttcgaataga agcgaaaaaa catttgctgc ttttagatat gcatcatatc 376381 atcgcagacg gcgtctcaag aggcatcttt gtaaaagaat tggcgctgct ttacaaagga 376441 gagcagcttc cggagccgac gcttcattat aaagatttcg ccgtttggca aaatgaagct 376501 gagcaaaaag aacggatgaa ggagcatgag gcgtactgga tgtcagttct ttcaggcgag 376561 ctgccagagc ttgatctccc gctcgattat gcccgtccgc ctgtgcaaag ctttaaagga 376621 gatacgatcc gtttccgtac gggaagtgag acggcaaagg cggtagaaaa actgcttgcc 376681 gaaaccggaa cgaccttgca catggtgctc catgctgttt tccacgtctt tttaagcaaa 376741 atttccggac agcgggatat cgtcatcggc tccgttactg ccggccggac gaatgctgat 376801 gttcaggaca tgccgggaat gttcgtcaat acacttgccc tgagaatgga agcgaaagaa 376861 cagcaaacat ttgcggagct tttggagcta gcaaagcaga cgaacctgtc agcccttgag 376921 catcaggagt atccgtttga agatctggtt aatcagcttg atctccctcg ggatatgagc 376981 cgaaacccat tgtttaatgt gatggtgacg acagaaaacc ctgataaaga acagcttaca 377041 ttgcaaaatc tgagcatttc accttatgag gctcatcagg gaacttctaa gtttgatctg 377101 acactgggcg gatttactga tgaaaatggc attggcttgc agctcgaata tgcgacagat 377161 ctgttcgcaa aagaaacagc tgaaaaatgg agcgaatacg ttctgcggct actaaaggct 377221 gttgcggata acccgaacca gccgctttcc agtctgttac tggtcaccga gacagaaaag 377281 caagcgcttc ttgaggcatg gaagggcaaa gcgctgcctg tgccgacaga caaaacggtt 377341 catcagctat tcgaagagac tgtccagcgc cacaaagacc gcccggctgt cacatacaac 377401 ggccaatctt ggacgtacgg cgagctgaac gcgaaggcaa accgcctcgc ccggattctg 377461 atggactgcg gcatcagccc ggatgaccgc gtcggcgttc tcacgaagcc gtcgcttgaa 377521 atgtccgccg cggtgctcgg cgtcttgaaa gccggagcgg cgtttgtgcc gattgatcct 377581 gactacccgg atcagcggat tgagtatatt ttacaggaca gcggcgcgaa gcttctcttg 377641 aaacaggaag gcatttcagt gccggacagc tatacgggag atgtcattct tctcgacgga 377701 agccgcacga ttctaagcct gccgcttgat gaaaacgacg agggaaatcc agaaaccgct 377761 gtaaccgcgg agaacttggc gtacatgatt tacacgtctg gaacgaccgg acagccgaag 377821 ggtgtcatgg tcgagcacca tgcgcttgtg aacctgtgct tctggcacca cgacgcgttc 377881 agcatgacag cggaggaccg cagtgcgaag tacgcgggct tcgggttcga cgcttccatt 377941 tgggagatgt tcccgacctg gacgatcggc gctgaacttc acgtcattga tgaagcgatc 378001 cgcctcgata tcgtccgcct gaacgattat tttgaaacga acggcgtaac gatcacgttc 378061 ctgccgacac agcttgcgga acagttcatg gagcttgaga acacatcact tcgcgtcctc 378121 ttgaccggag gagacaagct gaagcgggca gtgaaaaagc cgtacacact cgtcaacaac 378181 tacgggccga cagaaaatac ggtcgttgcc acaagcgcag aaatccatcc ggaggaaggc 378241 tcgctttcca tcggacgggc cattgccaat acgagagtat acattctcgg cgagggcaat 378301 caggtgcagc cggaaggcgt agccggagag ctttgcgtgg cggggcgcgg actggcacga 378361 ggctatctga atcgagaaga cgaaaccgcg aagcggtttg tcgctgatcc gtttgtgccg 378421 ggtgaacgca tgtaccgcac cggcgacttg gtgaagtggg tgaacggcgg catcgaatac 378481 atcggccgga tcgaccagca ggtcaaggtc cgcggctacc ggatcgagct ctcagaaatt 378541 gaagtccagc tcgcccagct ttctgaggtg caggatgcgg cggtgacagc tgtcaaagat 378601 aaaggcggca atacagcgat cgcggcgtat gtcacaccgg aaacagctga catagaagca 378661 ctaaaatcaa cactaaagga aaccctgccg gattacatga tcccggcgtt ctgggtgacg 378721 ctgaacgagc ttccggttac ggcaaacggc aaagtcgacc gcaaagcctt gcctgagccg 378781 gacatcgaag cgggaagcgg agaatacaaa gcgccgacga ccgacatgga agagctgctt 378841 gccggcatct ggcaggacgt gcttggaatg tctgaagtcg gtgtcaccga caatttcttc 378901 tcgcttggcg gagattccat caaaggaatt caaatggcga gccgcttgaa tcagcacggc 378961 tggaagctgg aaatgaaaga tctcttccag catccgacga tcgaagagct cacccagtac 379021 gtagagcgtg ccgaaggcaa acaggcagac caaggcccgg tggagggcga agtcatcctg 379081 acgccgatcc agcgctggtt ctttgaaaag aacttcacga acaagcacca ctggaaccaa 379141 tcggtgatgc ttcacgccaa aaagggcttt gatcctgaac gggtggagaa aacattgcag 379201 gcgctgatcg agcatcatga cgcgctccgc atggtctacc gcgaggaaaa cggggacatc 379261 gttcaggtgt ataaaccgat cggtgagagc aaggtcagct tcgaaatcgt ggatctgtac 379321 ggctccgatg aagagatgct gagaagccag attaagcttc tcgcgaacaa gctgcaaagc 379381 agtctcgatc tgcgaaacgg gccgctttta aaggcggagc aatatcgcac agaagctggg 379441 gatcacctgc tcattgctgt acaccatctc gtggtcgacg gtgtgtcatg gcggattttg 379501 cttgaagact ttgcttcagg ctacatgcag gctgagaaag aagagagcct tgtcttcccg 379561 caaaaaacaa actccttcaa ggattgggcg gaagaactgg cggcattcag ccaatcagcg 379621 catcttttac agcaggctga atactggtcg caaattgccg ctgaacaggt ttctccttta 379681 cctaaggatt gtgaaacaga gcagcggatc gtcaaggata catcatctgt cctatgtgaa 379741 ttaacggcag aagacactaa gcatctttta acagatgttc atcagccata tggaactgaa 379801 atcaacgata ttcttctcag cgcgctcggt ttgacaatga aagaatggac aaagggggcc 379861 aaaattggca ttaaccttga gggacacggc cgggaggaca ttatcccgaa tgtgaatatc 379921 tccagaacgg tcggctggtt tacggcacaa taccctgttg tgctcgacat atctgacgca 379981 gatgcctcag ctgtgatcaa aacagtcaaa gaaaacctgc gccgcattcc ggacaaaggt 380041 gttggctacg gcattcttcg ttatttcaca gaaacagcgg aaacaaaggg cttcacaccg 380101 gagatcagct tcaactattt gggccaattc gacagtgaag tcaaaaccga tttctttgaa 380161 ccgtccgctt tcgatatggg gcgccaagta agcggagaat cagaggcgct gtacgcatta 380221 agcttcagcg gcatgatcag aaacggccgg tttgtgcttt cctgctccta caatgagaag 380281 gagtttgaaa gagctacagt cgaggagcaa atggaacggt ttaaagaaaa cctcctgatg 380341 ctaatccgcc attgcacgga aaaagaagac aaggaattca caccaagcga cttcagcgcc 380401 gaagaccttg aaatggacga gatgggagat atctttgaca tgcttgagga gaatttaaaa 380461 taaaacgcaa gggaattaca gaaggcggga gcgaaacata tgagtcaatt tagcaaggat 380521 caggttcaag atatgtatta cctatcgccg atgcaggaag ggatgctttt tcatgccatc 380581 ctgaatcccg gccaaagctt ttaccttgaa caaatcacga tgaaagtaaa aggcagcttg 380641 aatatcaaat gtcttgaaga aagcatgaat gtgatcatgg accggtacga tgtatttcgt 380701 accgtgttca ttcacgaaaa agtaaaaagg cctgtccaag tcgtattgaa aaaacggcag 380761 ttccatatag aagaaatcga tctgacacac ttaacgggca gcgagcaaac agccaaaatc 380821 aatgagtaca aagaacagga taagatcagg ggttttgatt tgacgcggga tattccgatg 380881 cgggcagcca ttttcaagaa agctgaagaa agctttgaat gggtgtggag ctaccaccac 380941 attattttgg acggatggtg cttcggcatc gtcgtacagg atctatttaa ggtatacaat 381001 gctctgcgcg aacaaaagcc gtacagcctg ccgcccgtca aaccgtataa agactacatc 381061 aagtggcttg aaaagcagga taaacaagca tcactgcgtt actggcgcga atatttagag 381121 ggctttgaag gacaaacgac gtttgcggag caaagaaaga aacaaaagga cggctatgag 381181 ccgaaagagc tgctcttttc actgtcggag gcggaaacaa aggcctttac cgagcttgca 381241 aaatcgcagc ataccacttt gagtacggcg ctgcaggcag tctggagcgt attgatcagc 381301 cgctatcagc agtctggcga tttggccttc ggtacagttg tttcagggcg tcccgcggaa 381361 atcaaaggcg ttgaacatat ggtcgggctg tttatcaacg ttgtcccgag acgtgtgaag 381421 ctgtctgagg gtatcacatt taacggcttg ctcaagcggc tgcaggagca atcgctgcag 381481 tccgagccgc atcaatatgt gccgctttat gacatccaaa gccaggccga tcagccgaaa 381541 ctgattgacc acatcattgt ttttgagaac tatccgcttc aggatgcgaa aaatgaagaa 381601 agcagtgaaa acggctttga tatggtggat gttcatgttt ttgagaagtc gaattatgat 381661 ctcaacctga tggcttcccc gggagatgag atgctgatta agcttgccta taatgagaat 381721 gtgtttgatg aggcgtttat cctgcgcttg aaatctcagc ttcttacagc aattcagcag 381781 ctcatccaga atcctgatca gcctgtcagc acgatcaacc tcgttgacga cagggagaga 381841 gaatttttgc taaccggctt aaacccgccg gctcaagctc atgaaacaaa gcctctgacg 381901 tattggttca aggaagcagt gaacgccaat ccggatgcac cggcgcttac gtattccggc 381961 cagaccctgt cttatcgcga attagatgag gaagcgaacc gcattgcacg ccggctgcaa 382021 aaacacggtg cgggcaaagg ctctgttgta gcgctgtaca cgaagcgctc acttgaactg 382081 gtgatcggca ttctcggtgt attaaaggcg ggagcagcct atctgccggt tgatccgaag 382141 ctgccagagg accgaatctc gtatatgctg gctgacagtg cggcagcctg tcttctgacg 382201 catcaggaga tgaaagaaca agcggctgag ctgccgtata caggcacaac gctcttcatt 382261 gatgatcaaa cacggtttga agaacaggca agcgatcctg caaccgcgat tgatcctaat 382321 gatccggcat atatcatgta cacgtccggc acaaccggaa agccaaaggg caatatcacc 382381 actcatgcca atattcaagg attggtcaag catgtagact acatggcatt ttctgatcag 382441 gatacgttct tgtctgtttc gaattacgcc tttgatgcat ttacctttga tttctatgct 382501 tctatgctga atgcggcacg gctcattatc gcagatgaac atacgctgct tgatacagaa 382561 cggctcacag atctgatcct gcaagagaat gtcaatgtca tgtttgcgac aaccgcacta 382621 tttaatcttc tcacagatgc gggagaggat tggatgaagg ggcttcgctg tatattattc 382681 ggcggagagc gcgcgtcagt gcctcatgtc agaaaagcgc tgcggatcat ggggccgggc 382741 aagctgatta actgctacgg gccgactgag ggaacagtgt ttgcgacagc tcacgtcgtg 382801 catgatctgc cggattccat ctcctcattg ccgatcggaa agccgatcag caatgccagt 382861 gtttatattc tgaatgagca aagccagctc cagccattcg gggcggtcgg tgaactgtgc 382921 atcagcggaa tgggcgtgtc aaaagggtat gtaaatcgtg ctgacctcac gaaggaaaag 382981 tttatcgaga acccgttcaa gccgggagaa acgctttacc gtacagggga tttagcgcgc 383041 tggctgccgg atggaacgat tgaatacgcc ggccgtattg acgaccaggt caaaatacgc 383101 ggacaccgga ttgagcttga agaaatcgaa aagcagctgc aggaataccc aggtgtgaaa 383161 gatgcggtcg ttgtggcgga ccgccatgag tctggcgatg catcaatcaa tgcctacctt 383221 gtgaaccgaa cgcagctttc agctgaagac gtgaaggcgc acctgaaaaa acagcttcct 383281 gcttacatgg tgccgcaaac ctttaccttc ttggatgagc ttcctttaac gacgaacggg 383341 aaagtcaata aacggctgct cccaaaacct gatcaggatc agctggcgga agaatggatt 383401 ggaccgcgga acgagatgga agaaacaatc gcacaaatat ggtctgaggt tctcggcaga 383461 aagcaaattg gcattcatga cgatttcttt gcgctcggag ggcattcctt gaaggccatg 383521 accgccgcgt cccgcatcaa gaaagagctc gggattgatc ttccagtgaa gcttttgttt 383581 gaagcgccga cgatcgccgg catttcagcg tatttgaaaa acgggggctc tgatggcttg 383641 caggatgtaa cgataatgaa tcaggatcag gagcagatca ttttcgcatt tccgccggtt 383701 ctgggctatg gccttatgta ccaaaatctg tccagccgct tgccgtcata caagctatgc 383761 gcctttgatt ttattgagga ggaagaccgg cttgaccgct atgcggattt gatccagaag 383821 ctgcagccgg aagggccttt aacattgttt ggatattcag cgggatgcag cctggcgttt 383881 gaagctgcga aaaagcttga ggaacaaggc cgtattgttc agcggatcat catggtggat 383941 tcctataaaa aacaaggtgt cagtgatctg gacggacgca cggttgaaag tgatgtcgaa 384001 gcgttgatga atgtcaatcg ggacaatgaa gcgctcaaca gcgaagccgt caaacacggc 384061 ctcaagcaaa aaacacatgc cttttactca tactacgtca acctgatcag cacaggccag 384121 gtgaaagcag atattgatct gttgacttcc ggcgctgatt ttgacatgcc ggaatggctt 384181 gcatcatggg aagaagctac aacaggtgtt taccgtgtga aaagaggctt cggaacacac 384241 gcagaaatgc tgcagggcga aacgctagat aggaatgcgg agattttgct cgaatttctt 384301 aatacacaaa ccgtaacggt ttcataaatg aagtgatgaa aggaggagac agccaatgag 384361 ccaactcttc aaatcatttg atgcgtcgga aaaaacacag ctcatctgtt ttccgtttgc 384421 cggcggctat tcggcgtcgt ttcgccctct ccatgctttt ttgcaggggg agtgcgagat 384481 gctcgctgcc gagccgccgg gacacggcac gaatcaaacg tcagccattg aggatctcga 384541 agagctgacg gatttgtaca agcaagaact gaaccttcgc cctgatcggc cgtttgtgct 384601 gttcggacac agtatgggcg gaatgatcac cttcaggctg gcgcaaaagc ttgagcgtga 384661 aggcatcttt ccgcaggcgg ttatcatttc tgcaatccag ccgcctcata ttcagcggaa 384721 gaaagtgtcc cacctgcctg atgatcagtt tctcgatcat attatccaat taggcggaat 384781 gcccgcagag cttgttgaaa ataaggaggt catgtccttt ttcctgcctt ctttccgatc 384841 agattaccgg gctcttgaac aatttgagct ttacgatctg gcccagatcc agtcgcctgt 384901 tcatgtcttt aacgggcttg atgataaaaa atgcatacga gatgcggaag ggtggaagaa 384961 gtgggcaaaa gacatcacat tccatcaatt tgacggcggg cacatgttcc tgctgtcaca 385021 aacggaagaa gtcgcagaac ggatttttgc gatcttgaat cagcatccga tcattcaacc 385081 gtgatcaaaa gcggacagct tcggctgttc cgcttttttt gtgttgaatg ccaatttctg 385141 catggtataa tagtcgaaat actcaaataa aggcaggtcg aaacatgcgc acgtctccca 385201 ggatgaaatg gtttgtattg ctgtttacgt ttgttttcgc catcggaatg aactcattca 385261 gaaattcctt tcaatttttt atgctgccaa tggcagacgc cttccatgcc gacaggtcgc 385321 tgatttcggt ttctgtcagc atttttatga tcacaaccgg catcgtccag ttttttgtcg 385381 gtttttttat cgaccgtttc agtgtcagaa aaattatggc gctgggagct gtttgcatca 385441 gcgcaagctt tttggtgctt ccttattcac cgaatgttca tgtgttttcc gccatttacg 385501 gtgtgcttgg cggaatcggg tattcctgcg cggtcggcgt gacgacccag tatttcatca 385561 gctgttggtt tgacacacac aaaggtctgg cgcttgctat tttgaccaat gccaactctg 385621 cgggcctgct gcttctctcg cccatttggg ctgcggctcc gtatcatgcc ggctggcaga 385681 gcacctatac cattttggga atcgtcatgg cggctgttct gctgccgctc ctcgtctttg 385741 ggatgaagca cccgccacat gcgcaagcgg aaactgtgaa aaaatcttat gattggcgag 385801 ggttttggaa cgtgatgaag caatcccgcc tcattcatat cctgtacttc ggcgtgttta 385861 cttgcggatt tacaatggga attattgatg ctcacctcgt cccgatactg aaggatgcgc 385921 atgtctctca tgtcaacgga atgatggccg cgttcggggc atttatcatc attggcggat 385981 tattggcggg ctggctgtca gatctcctcg gcagcagaag cgtcatgcta tccatcttat 386041 ttttcattcg gctgctcagc ctcatttgcc tgctcattcc cattctcgga attcatcaca 386101 gcgacctttg gtacttcggg tttatcctgt tattcgggct cagttacaca ggcgtgatcc 386161 cgctgaccgc ggcgtcaatt tcggaaagct atcaaacagg attgatcgga tcgctgttag 386221 gcatcaattt ctttatccat caggttgccg gagctctcag cgtgtatgcg ggcggtttgt 386281 tttttgacat gactcatggt tatttactga ttgtcgctgt gtgcatcgtg tttgtgggtt 386341 tatcggctgt aatagagctg gtgccgtttt tagataaaca gaaggcaaaa gaaacccacc 386401 attcaatata aaaggatcag cactgtcaat gctgatcctt tttaaatttg agtttttttg 386461 tttcggtatt tttaaggata atctccttga atctgttcat ctcctcttcg gagtgaaaaa 386521 aatgtttggg gatcgcaata tattggccac ttgatgtatt gaccctgaag atatttttat 386581 attcgaaaac agctgtaatt tcatcccaat tgaaaatgag gtcatatttt ttagaacata 386641 tacgaattcc ttcttggttc agagtatatg ttcttttgga tttcatccgt tcgttcttct 386701 tgtatgctct ggaaaacttc acatatagaa gaaggaggag cagcagtgta aacagaacgg 386761 acatcacgat aatcaacata ctgttcataa acaagttaag cgcgtcactt ccataaacga 386821 tacggggcca tccgttaatg aagttaactg cagcaaatat ggcgcaaaac aatagaaagt 386881 aaaagcatga tatttttgcg atttgataaa aaaagatttc tcttacatcc ttaaaagtga 386941 tttctcctgg aagattgata ctttcactag catattgaat catacggtaa acctacacct 387001 ctaaccatgt ttttcctttt agtctagcat aatttctcat ttttttgcag gcataccagg 387061 gcgctttgtt tttttctcca gattgatatt gctccccacc acgccaatca taatacaaac 387121 agccccggca agatgatacc aggccaggct ttcgttgaga atcacaaatc ctgcaatcat 387181 cgtcacaatg gtagatacat gattaaaagc gctcatttta aacgcctcaa ttcgcgacag 387241 cgtatagtta gacagaaatg aagtgacaag tgaagacagc acgcccaaat acacaatggc 387301 gagaacgaag ccgggctccc ggaacggcag aaaataagtg ccgactgttc ccgccgctcc 387361 gtgacgcaca agggcgatgg cgttgaagac gacaaagccg atggctgaca tgatgtaggt 387421 gagctcggtc agcttgaacc gctgcgtcat ttttctggca gcagtattgt acatcgctga 387481 agacaaagcg gacaatagga tcagcaaaga cccttttaag ctggctgatt ccacgtcaac 387541 gcctttcatc acaaaaataa acatgacgcc ggcaacggat aaaaccgtga accccttttg 387601 cgtccacgtt gggcgttcct ttaaaacata agcggcaaag accatcgtga aaatcggaat 387661 ggctgcctga ataattcccg cttcagagga ggacgagtac acaaggccga atgcctgaaa 387721 gctgaaaaat aacgcgggat acagcagggc gagcggcaaa atgtcaatga cgtcctttac 387781 gcggattgat agctttaccc agccgaataa gatcggtaca gtggccgcag caaacgcaat 387841 ggtgaaccga tgcgccaaaa tatcaaacgg ctctgctgtt tgcagtgcga tttttacgaa 387901 tagaaaggat aaaccgataa tgaacgaata taaaatagcc gctatataag cgggggtttg 387961 ctgatgttta accataatgg gaagggctcc tttacctgaa ttgcagcgcc ggtcgctccc 388021 tttattgtat ggccgcggtc agaacggtac aatgagaaaa acaatgaact gtaccggtac 388081 aaaacagggg gagaaggcat ggagaaatat atgagtctat taacgaggat agaggagatg 388141 atgcaaagca cctcatatca agaaggagac aggcttccat ctatccgtca gctgtccgcc 388201 cgctaccaag tcagcaaaag cacagtgatc cgcgcgctgc aggagctgga aaagcgccac 388261 cttatctatt ctgttccgaa aagcggctat tatattgtga aaaagtcagg gaaatcaaaa 388321 agcgggcagc ctggccccat cgactttgcc acatctgcgc cggatcccga tgtgtttccg 388381 tatcttgatt ttcagcactg catcaacaaa gcgattgata catacaaaaa cgatttgttt 388441 atttatggga cgccaaaggg gcttccatca ctcatccgcg tactccgaaa gctcttggcc 388501 actcaacagg tatttgcgga tgaacggcat attttcatta catcaggtgt ccagcaggcg 388561 ttatccttgc tttgtgccat gccgttccca aatgggaaag agaagatcgc cattgaacag 388621 ccgggctacc atttgatggt cgaacagctt gagacacttg ggattcccgc catcggggtg 388681 aaacgaacgg aagaagggct tgatatagcc aaggttgagc ggttatttca aacagaatcg 388741 attaaatttt tttatacgat gccgcgcttc cataacccgc ttgggtgctc attgtcagag 388801 cgtgataaac aggagcttgt gagactggca gaagcgtatg atgtctatct cgttgaggat 388861 gattacctcg gtgatctgga ggaaaataaa aaggcagatc cgctgtacgc atatgatctg 388921 tcctcacatg tcatctattt gaaaagcttc tcgaaaatga tgttccccgg cctccgcgtg 388981 ggggcggctg ttttgcccga agcgctgact gacacgttct atgcgtacaa aaagctgaac 389041 gacatcgact gttcgatgat ttctcaagcg gcattggaga tttacctgaa aagcggtatg 389101 tacggcaggc ataaggagaa aatcagagat tcttataaag agcggtcgct gaggctacat 389161 caagccattc gaactcacag gcagctggga agcggacgct ttacgttctc cagcgggcag 389221 gcaccctgta tgcacaccca tctggtgctt cctcaggatc tgcccgcctc aagagtgatt 389281 catagactgg aaaaacaagg ggttctcctt gaggcgatag accgtcatta tttatcagat 389341 tatccgaaag aaaatctatt aaaaatcaat atttccaatg tgaaaacgga agatattgag 389401 cgcggtgtca agctgttgat gagccattta taaaagctct tcgtacgaga ccattgtgat 389461 atcctcgggg aaatcagggt gtacggcgca tacagccatt ttgtagccgg gatcgacctc 389521 atacgttttg atatagcatg gggaatggct gtccggaagc tcaatggata cttgtccgtc 389581 ctggtgcagg cgcactgaaa aggaatcaag cggaagcgat aagcctttgc cttccttgtt 389641 tgataaagct ttctttcatt gaccatagat gataaaaata gtctgtctgc tcgtccttgt 389701 cttttgctaa aaggtcgctg tactctgttt ttgaaaagaa gcgcttggcg atctcaaggc 389761 tgatcggttt cgttttttcg atatctatgc cgatcggctg tgaatcaaac gcgcaaatga 389821 cccagcgtcc ggagtgagaa atgttgaaat gagcgtcggg aagatcaggg atgcacggct 389881 tcccgtattc ctgcgtgcta aagcggatat cggatttgtc caactgatac tgcctgctta 389941 tgactgagcg aacgagcaca tctcccagca gggtgcggtg agcatcttct ttatgataaa 390001 atctccggca tttctcccgt ttttcaggtg atatgaaaga catgaaccgt tcattttctt 390061 cctgtgaaag cgggcggtcc atataaattc cgtaaatctt cattctagat cctccgtctg 390121 caaaagattg tcaaaaccat cctatcatac ttccacaaga ctcatataga ggagaaaata 390181 aaaaaacaaa gccaaggcgg ctttgtttta gtgtacaggc ggagatgctt tcactgcggc 390241 tgtccgcctt gccacagcat aattcagcaa ctggattgac tggggcaatg aaaaacgcaa 390301 aataagtccg gtgaggatgg cggtcaaaat ggtgccaaaa ccgatcggtc cgcccatgcc 390361 ccatgccgca aacaaaatgg ttaattccat gccgttccgc acccattgca cattccagcc 390421 ggttttttct gtaatcagca tcatcagtga atcacgcggc cccgcgccaa ggcctgctga 390481 tacataaaca ccgacgccgt aaccaatcag caccacgcct agagagaaga cgatgatcga 390541 gcctgtgtag gtcgagaggg caggcagaat gaaattgaaa aaatctataa atacaccaat 390601 gagcaccata ttcaggaggg caccaatttt cggccaagct ctcgtaaaca atgacgtgaa 390661 tccgacgatg agcgctccaa taatgatgga ccactggccg acggtaagcc cgaagtgctg 390721 aaacaggctg taatgaaatg catcccacgg actaatgccg agtgcttttc cttctatcgt 390781 cagggataca ccaaaagcca aaatgatcaa accggcaaaa taaaatgtcc agcgcagaac 390841 aagttcttgc ttcacgtgag gtcccttctt tcgtaaaaat cagtcgattg tcattgtagc 390901 acatctgaca gaagggcgga ataggcgaaa ggggctcaac aaaaaaacag ggccgccgga 390961 ggcgccctgt ttcagcgtgt tggcaaaccc ttgcattcgt tgtcaggcct gtgcttcggt 391021 gctcacgaat ttaacattag ctgtgctcca atgctcgccc ttcctagact tcaaaggttt 391081 tcaatcacgc tgaaaatcac aaaatcctaa aacgaatatc gttttaggat tttgtcaata 391141 atctgaaaca gggcgctgac gctctgtttt tcttattaca gcgggttcaa aatccggttt 391201 aagaaccgct gtgtccgttc ttcttttggt gcggagaaaa tttgctccgg cggtccctgc 391261 tccacgataa cgccgccgtc gatgaagatg acttcatccg caacctcctg cgcgaacttg 391321 atttcgtggg tcacgacgac catggtccag ccttcattgg ccaagtcctt gataaccttc 391381 agcacctctc cgacaagctc gggatcaagc gctgaggtcg gttcgtcaaa cagcatgagc 391441 tcaggctgta tcgccagtgc gcgggcgatg ccgacgcgct gctgctggcc gccggaaagc 391501 tggaacggat ataaatccat tttgtccttc aatccgactt tatcaagaag ctgaatcgct 391561 tcttttctga cttcctcttt gttccgtttt tgcacctgaa cagggccctc catcacgttt 391621 tcgagggctg tgcggtgcgg gaacaggtga tacgcctgaa acaccattcc ggattttcgg 391681 cgaagcttta ggatatccgc ctgtttcacc tttttggaga aatcgatgga gaaatcatca 391741 aatgcaagct ctccgcgatt cgggatctcc agagcgttca ggcagcggag cagcgtcgtt 391801 ttccctgaac ctgaaggccc aagtatggcg atgacttttc ctttttcaat cttcatatct 391861 atctttttta aaatttcatt ttcaccgaat gatttgttta atcctttaac ggtaagcata 391921 ctcggaacct ccttatttgg ccacgtagcg gtcaagacgc cgttcgatga catgctggac 391981 gagtgagagc aggaagcaga taatccaata aataaaggct gcttcaatat agatcactaa 392041 aatttgatca agattccgcg cgccgatttc ctgggctttt ctgaacagct cagcgaccag 392101 aatttgagag gcgagggatg tatctttaat caggctgata aaggtattgg ataatggcgg 392161 gatcgacaca cgaaacgcct gcggcaaaat gacgcggaac agcgtttttt gatgtgtcat 392221 gccaattgtg tagccggctt cccattgccc tttcggcacg gataaaatag atgcccgaat 392281 gatttcagat gcataggcgc cgacgtttaa tgaaaaggcg ataactgcgc ttggaaatgg 392341 atctaatgtg acgttaaagg ccgggaacag atagaaaatg atgaacaatt gaacgagaag 392401 aggagtgccg cgtattgcgg atacgtatac gctgaacacc catctcaaag gtctcacttt 392461 cgacattctg gcaagcgccg taatcagcgc caggatcatt ccgaatataa aggaaagaat 392521 cgtaagggga atcgtatagt agattccccc tgaaagtatc ggccagaatg actgctgcac 392581 cagatcccac gggatcgccg tgccaagcgt caatgccggc agattattta gaaacatctt 392641 cgccgaacca ttttttagaa attttagaaa gagtcccgtc ctctttcatt tcttttaatg 392701 ctttgttgac ttgatcaaca acctcgccgc ttcctttacg gaacgtgaaa tatgttgact 392761 gaggctcacc tgtttcaaac gcgattttca cgtttttatt gccagatgtt tttaagtagt 392821 tcaatacggc aagcttatcg ttgtatgtca tatcgacgcg gccttgctgg atcatttgaa 392881 gggcctgcgc catgccttca acgccttcta ctttagcgcc ggcatttgta gctaatttgt 392941 tgtagttgct tgtcagtgat tgagctgacg tttttccttt tacatctgct tcagacttaa 393001 tatcgttgtt gtcttttttc gttacgacaa cggctcttga tgttgtgtat ttatctgaga 393061 aatcatattt gtcttcacga tctgtttttc cgacttggtt ggcaacaacg tcaaaccgtt 393121 tggaattcag gccggcaaac atactgtccc attgtgtttc cttaaagtcg actttaagcc 393181 cgaggcgttt tgcgacttct gtgataactt cgacatcata gccagtcagt ttatcagtgt 393241 ctttgtcgtg gtaagtgaac ggctcatatg ttccttccgt tccgactgtg agcacacctt 393301 ttttcttaat tgaagcccaa agatcgccat ctttggcatt atcttttgac tgattgtcat 393361 ttcctgctcc gcaagctgca agagctgcaa tacttacgac catgaataaa gccaataatg 393421 cttttttcat cttattcccc acttttctgg ttgattttat tgaaataaaa aattagctta 393481 caaatctaaa ggataacttt tttttagtat gagtcaagta tttggttttc ataagacaaa 393541 atcttttaaa ataaatccaa aaattgctgt gccggtttag gcaaataact gtccgttctc 393601 cacatgacag ccggtgtcat aatgaaggga ttattttcga tatggacggt gtgaacgtga 393661 tttctcatat gaacgggaat cattgtgaca ggcaaaatag acgcgccgaa tccggatgac 393721 acgaggctga gcaaagttgc agagtcgtgg cattcacaaa caatgcgcgg ctccaggttc 393781 aaacgatgaa attcattcat gacctgatta tagacgcctt ttccgttgac aggccgcagc 393841 aggatcagcg gaaatgaagg aatgtccacc atcttaatgg tgtctccgca cggatatccg 393901 gcttcatctg aaagcacgag cacacatgga atgtcatcaa gctgcttgaa ttgtactgtg 393961 tcacttttga tcagtgttgt cgtgaccgcc gcatcgattt gccggctttc cagcagttcc 394021 aacagtgtcg cgggttcatt ttcccaaata ttaaaggtga gatgggggta tctctctttg 394081 atctgtgtta ctttttcaag catcagagcc gcgcaataaa tcgttgatcc cacggcaagt 394141 gtaccggcta cttcctcctt cagctcctgt acctcaatga ctgcatcttc aaacctatgc 394201 agaatctctt ttgctctttt tagaaaaaca gctccttcat atgtaagagt catttgtttt 394261 ttcttgttac ggtcaaacag aacaacacca agttcgtcct ccagctgttt gagctgcctg 394321 cttaaaggcg gctgcgccat gtgaagcttt ttggctgcgg acgtaatttt ctgttcttgg 394381 gcaatggtaa tgaagtatcg aagctggcga atatccaaaa gaaagcgcct ccttatcata 394441 ccttttaggt attaattata gatttaatag atatttttca tatggatata tcaggagtat 394501 gattgaaatg aaagcagaat tcaagcgtaa aggagggggc aaagtgaaac tcgttgtcgg 394561 aatgacaggg gcaacagggg ccattttcgg ggtcaggctg ctgcagtggc tgaaggccgc 394621 cggagtggaa acccatctcg ttgtgtctcc ttgggcaaac gtcacgatca aacacgaaac 394681 aggctatacg ttacaagaag tagaacaact ggccacatac acttactcac ataaggatca 394741 ggcggcagcc atttcaagcg ggtcgtttga taccgatgga atgattgttg cgccgtgcag 394801 catgaaatct ctcgcaagca ttcgcacagg aatggcggat aatctgctga cacgtgcggc 394861 ggatgtcatg ctcaaggaga gaaaaaaact cgtcctctta acgagagaga cgcctttgaa 394921 ccaaattcat ctcgaaaata tgctagcgct tacgaaaatg ggcaccatca ttcttcctcc 394981 gatgccggca ttttataatc ggccgagaag cttagaggaa atggttgacc atattgtttt 395041 tagaacgttg gaccaattcg gcattcggct tcctgaagcg aagcgctgga atgggattga 395101 aaaacaaaaa ggaggagctt gatcatggct tatcaagatt tcagagaatt tctcgctgcc 395161 cttgaaaaag aaggacagct gcttacagtg aatgaagagg taaagccgga accggattta 395221 ggggcctccg cacgggcagc cagcaatctt ggcgataaaa gccctgcgct cttatttaac 395281 aacatttacg gctatcataa cgcgcgaatt gcgatgaatg tcatcggctc ttggccaaac 395341 catgccatga tgctgggcat gccgaaagac acaccggtaa aagaacagtt ttttgaattc 395401 gcaaagcgtt atgaccagtt tccgatgccg gtcaaacgtg aggaaacagc gccatttcat 395461 gaaaatgaaa tcacagaaga tatcaatttg ttcgatatac tgcctctttt cagaattaac 395521 cagggtgatg gaggctacta tttagacaaa gcatgtgtca tttcccgtga tcttgaggac 395581 cctgacaact tcggcaaaca aaatgtcggc atttacagaa tgcaagtcaa aggaaaagac 395641 cgccttggca ttcagcctgt cccgcagcac gatattgcaa tccatctgcg ccaagctgaa 395701 gaacgcggca tcaaccttcc ggtcactatt gcgctcggct gtgagccggt cattacaacg 395761 gcggcatcga ctccgcttct ctatgatcaa tcagaatacg aaatggcagg tgcgattcaa 395821 ggcgaaccat atcgcatcgt caaatcaaag ctgtctgatc ttgatgttcc gtggggcgct 395881 gaagtggtgc ttgaaggtga gattattgcc ggagagcgcg aatatgaagg gccgttcggt 395941 gaattcacag gccattattc cggcggacgc agcatgccga ttatcaaaat taaacgcgtc 396001 tatcacagaa acaatccgat ctttgaacat ttatacttag gcatgccttg gacagaatgc 396061 gattacatga tcggcattaa cacatgcgtg ccgctttatc agcagttaaa agaagcgtat 396121 ccgaacgaaa ttgtggcagt gaacgccatg tacacacacg gtttaatcgc gattgtttcc 396181 acaaaaaccc gctatggcgg atttgcgaaa gcggtcggca tgcgcgcact cacaacgccg 396241 cacggactcg gctactgcaa aatggtcata gtcgttgatg aggatgtcga tccattcaac 396301 cttccgcagg tcatgtgggc gctttcgacc aaaatgcatc cgaaacatga tgcggtcatc 396361 attccggact tatctgtcct gccgcttgat ccgggatcca atccatcagg aatcactcac 396421 aaaatgattc tcgacgccac tacaccggtt gcgccggaaa caagaggcca ttattcacag 396481 ccgcttgatt ctccgctaac aacgaaagaa tgggaacaaa aactaatgga cttaatgaat 396541 aaataaggaa aggatgttcg aaatgcatac atgtcctcga tgcgactcaa aaaagggaga 396601 agtcatgagc aaatcgcctg tagaaggcgc atgggaagtt tatcagtgcc aaacatgctt 396661 ttttacatgg agatcctgtg aaccggaaag cattacaaat cccgaaaaat acaatccagc 396721 gtttaaaatt gatccaaagg aaacagaaac agcaattgaa gttccggcgg tgccggaacg 396781 aaaggcttga tccgcgtgaa ctgtatgtca gaccgtctct ttgagctgct tgacgggagc 396841 tgcctgaatg agaagcagca tgaggccttc gttctgcaaa cagtatcaga ggatggctgg 396901 ccgcatgccg ctatgatcag tgcaggtgaa atcatcgcgc tgagccgaac tgatatccga 396961 atcgctctgt ggaaaaacac aatgacttcg gccaacatcc ttcgcacagg aaaagcacag 397021 ttcacggcgt ggtggaaggg agcggcctat tatgtaaagc ttgaatgcgc gcctttaccg 397081 cctttgaaag atgccgaata tgaaagagac cgtttttcct gccgcatcgt ttcagtgaaa 397141 gaggacgttg cgaaatacgc tgatttgact tcaggtgtcc gtatacagct tcacagccct 397201 gaagaggtgc tgagcagatg gaaaaagacc ctggaagatt taaaacggta atatcgatag 397261 cctgacgcca tgcgtcaggc tttttttata taatgaaaac aaaagggggc gtgagaaatg 397321 gaacgtgcgg ggatctgtca ctcggacggc tttgatttag cttatcgaat tgagggcgag 397381 ggcgcaccca tccttgtgat cgggagtgcg gtttactatc cgcgcctttt ttcctcagat 397441 atcaaacaga aatatcaatg ggtctttgtc gaccataggg gatttgctaa gcctaagcgg 397501 gagcttcgtg cggaggattc gaggcttgat gctgtcttgg ctgatatcga aaggatgaga 397561 acatttcttc agcttgagga tgttactatc ctgggacatt ccgggcacgc ttttatggct 397621 ttagagtatg ccaggacata tcccaaacaa gttcggaagg tggcgctctt taatactgcg 397681 cctgataaca gtgaagaaag acagcgaaaa agcgaatcat ttttcatgga aacagccagt 397741 cttgagagaa agaaacgctt tgaaaaagac atcgagaatt tgccgcagga catcgacaaa 397801 gatcctgaaa ggcgctttgt gcacatgtgt attcgcgctg aagcgaaaag cttttatcaa 397861 gagcggccgc atgctgctgc cttatgggac ggtgtattca cgaatatgcc gatcattgat 397921 gaattatggg gcaatacatt tgcccggatt gatcttcttc agcggttagc tgatgttcgt 397981 atgccggtgt atatcggatt agggagatat gattatttgg ttgcgcccgt ttcgctatgg 398041 gatgctgttg acggtttata tccccatgtt gataaggtta tttttgaaaa gagcggccat 398101 cagccgatgc tggaagaacc ggaagccttt gatcaaagct tcaggaaatg gcttgatcaa 398161 taaaaaacag cccgcagatc aacatccgcg ggctgtttct gattataaga cccctttcat 398221 cgcgcgtttg atcaccggcg agagcagcag gagaatgccg ccaagaacga tagaaatcaa 398281 accgatggtg ccgaagtaca ttgtttcagg aattttatca aacaatccgg ctacttgggc 398341 attgatcgct tgggctgctg cgttcgtcag aaaccacata ctcattgtct gtgcagagaa 398401 ggcagctggt gccagtttcg ttgtcacgga taaaccgact ggagacaggc acagctctcc 398461 aagcacgaca agcaggaagc tgagaacgag ccaaagcggg cttacgagtg cttcttttcc 398521 ttgcatagca gggaatacca taatgataaa tgacaatccg gctaaaataa ttccgattga 398581 gaatttaact ggtgtagacg gctgacgttt gccaagcttc atccagagcc atgcgaatat 398641 tggcgcaaaa atgacaacaa acaatggatt taatgattgg aaccatgatg actgaagttc 398701 gaatccgccc aatgaaagtc ttatgcgttc atcagcgtat accgcaagaa tggtcgctcc 398761 ctgttcctga atggcccaga acatgacagc accgataaac aaaggaacgt aagcggcaag 398821 acgggatttt tctgttttgt ccgctttttt gcttgtaaac atgatgatga aataaatcac 398881 aggaatcaaa ataccgagaa tacttacaag gtcaatgaaa cgtttgatcg tcagcacgcc 398941 tgtttgtaca gagataatca ctgcgatcgc cacaatgata acaccgattc cggtgccaat 399001 tgcagatttt ttagacagcg gattcggcac attggaacct gcaagcccga ggtttttctt 399061 tcttgtcaaa gcaaatacga taagtccgag aagcattccg accgcggcag ctccgaatcc 399121 gagatgatag ttgtacttct gtccgagtgt tccgacaatt aacggcgcga gtaaaccacc 399181 gaggttaatc cccatgtaga aaatactgaa acctgagtcg cggcgcgggt cttctttcgt 399241 gtaaagatcc ccaactacgc ttgaaacgtt tggttttaat aagcctgttc cgacaatgat 399301 aagcaccata ctgatataga atgctatcga actgcccgga taggcgagtg caatgtggcc 399361 gaacataatg aatatgccgc cgtaaaacac ggtgtttgcg gtaccgaata cccggtcagc 399421 gagccatccg ccaataatgg tggacatgta tacgagtgat ccgtaaatcg acataatggc 399481 aaccgcagtg cccttgtcaa agccgagccc tccgtttacc gtctctgtat acaaatagta 399541 aagtaagatt gctctcattc catagtaaga gaaacgctcc caaaattcgg tgaaaaatag 399601 tgtaaatagt cctcgcgggt gaccaaagaa ccctttttgc gggacgcttt taatgatact 399661 ttcgttatca atcgaagcca tgtcagccaa accctttcta aaaaaagtgt attataaaaa 399721 tcatattctt atataatact tgtgtcaata taatttatac tcatttcaaa tagttccata 399781 ttggaaaaat tataaatacc taaaaatagt gatttcctcc taatttttaa actttttatc 399841 gtgagatttt cttacacaac tattccttta tattttttta ataaaatttt agagaaatgt 399901 acaagcagat cgggcctttg tgagtaacat gatagtaatc atagagaagg aggctcgcaa 399961 ttggctgaat tcatattaaa tgcagcggat ttcggtgttc ctagagatgg taaaacggat 400021 tcgacagaac ggattaatca gtgcctcagt acagctgttt cgaaaggcta tcatactgtc 400081 tggtttccaa agggaacata tttaatagac gcaacgcttg gcggagatct taatcagagg 400141 tttcgaaacg cggggatcat tgttcccggc aaccttgaga ttatgatgga ccccgaatgt 400201 atcatgaaag tgataccgaa tagttcgtgg ggttattccg cattttatgt aggcaagcaa 400261 gagaatataa ctatttccgg aggacaaatt atcggcgaac gggatgagca tacgtatgcc 400321 tcggcgggga taaggtcaac ccatgaatgg ggctttggca tatgtattga aggatgctcg 400381 aatgttgtca ttgatgatgt gaaaatttcc gattttaccg gcgatgggat catagtcagc 400441 ccaaggggat taaagaccaa tcaagattat cgaacgtcag agcaaattat catccgccgc 400501 tgtgaggttc ggcggtcgag gagaaataac atttccatta ccggatgtga catggtcacg 400561 gtggaggaat gcttgattga agatgccgga acggggaatg gaacagcgcc gaaattcgga 400621 attgacattg aaggatatgg cgaaggtgac gttgattatg aggaaccgat taatgtatca 400681 attcgcaata accactttgt tggaaacgtt tcaagttctg tgaccaattt taacgggtat 400741 ggcattttaa tagaaggaaa tcactcagac aatacaatca gctacggata tgggacgcaa 400801 acagtgatca agggcaatat tctgagacgc cctgaagacg cggcggctgc gccaagagtc 400861 gggataaccg gactcggtgt atcacaagga aaagagacca gtgatgcagt gatcgctggc 400921 aacctcatta ccggattttc aactggaatt gatgtcaggg gaaagagcgt tcttgtgacg 400981 aacaacaaaa tcagcaactt tgaaaacaca gggatattgg tttatcagtc ctccgacgta 401041 aaggtagacg gaaaccaaat tcaaaacgga ctgtctgaaa caaggcgcag catcggtctt 401101 cgcgcagtgc tgtcagatga catcgcattt ctgaataact gtctcattca agtcgttgac 401161 ggtgtgaacg tttccggcgg aaatatgatc attaaagata atctcctgag aaaattcagc 401221 cggggcattt ggattgctca agggaacgcg gtgattgaag ggaatacact gaatcctgac 401281 gcgtttgaag cagtgccgga atcatattct gtttccgtca caaacaatgc cggcgccatc 401341 atcaaaaaca atacatttaa agagttcaaa aattacccca tttattgctc cacaagtgca 401401 aaaacctcaa ttatcggcaa ccacttagag cgatccccgc ttttggtcac catctatatc 401461 agcgcaggtg tgcatgagat ttttgataat accatttcag tcaacagaac agccgggaat 401521 ccgattgtga tttatctcaa tggctctgca ggctctatca tctctggaaa caccatcaat 401581 aacctctccg cgggcactgc gacagctatt caaacaaaca cgtcaaccaa ttccaaaatc 401641 atcggcaacc gcatttttaa agggaccatc aacaaacaca gcagtgatac aatagacggc 401701 aatatgattg tctgaaaaaa gcgcccccct ttaggggttc ttttttttcg atttatagat 401761 cacgtacatt tctctcacaa gtactaacac aaaaaataaa agcacgaccc attccgcaaa 401821 tgttgtcatc ttaaagctgg acatattgtt ataaacggct tttgttaaac tgaacccttg 401881 aagcatgtcc atcaacacag aaatagctaa taaacaaatt aatatgaatc cggtcacgcc 401941 caatatcttc atgcttcatc atcctccgct tttagtgtct atctttggcg gagaagttat 402001 accgcatcta accctaatgc ataatctcaa ttttaaaagg aagaatatga gaaaacgaca 402061 aggaaaggta tttgtgtatg cctttatttt ctaagcgaaa gaacaatacc gattcaaaag 402121 acaagcagaa tacagacgaa aggaatcagg aacagcagca agaaaaagaa aggccggttc 402181 tcatttctcc aagtttagca aagaatatag cggaaacgaa aaaggaagtc ggaagcagct 402241 ctgacgtcat cattcgcgag attaaaatcg gggagcagga tcatgtccac ctagctgtta 402301 tctatatttc tgggctggtc gataataaca cgatccatga gtcgttaatt gacccattgg 402361 tacaggatga gtctatccag aatactcatg cgatccagca aattcttgaa aaaacgctcc 402421 cgctgggcgg ggtgaaagcg gaaaagagct gggacaagct tttttccgag ttaatgcttg 402481 gcaatgcgct catttttgct gatggccatg atgaagcttt gatttgcagc actcaagggg 402541 gagagcagcg ctccatccaa gagccgagca cccaggtgtc attccgcggc ccgcgccaag 402601 ggtttacaga gtctctgcaa accaatattt ccatgatccg gcgatacatt aaaaatccga 402661 atttatgggt tgaaaaaatg aaaaaaggtt ctgttacgaa tacggatatc gctctcatgt 402721 acattcaagg aatatgtgat gaaaaggtgc tgaaggaagt gaaacagcgc ctggaaaaaa 402781 tagatattga cagtattttg gaatctggat atattgagca gctgattgaa gatgaaacct 402841 ttacgacgtt tccgactatg tatcatacag aacgccctga tgttgtagcg ggtaatctgt 402901 tagaaggaag attcgcgatt attgtggacg gaacaccgtt tgtgcttatt gccccagcct 402961 tatttgtcca gttttttcag tctgttgagg attattattc gcgttttgac attgcgacaa 403021 gcataagaat tcttcgtgtt ttagtctttt tcatttcgct tgtggcacca gctgtatacg 403081 tggcagccac gacgtttcat caagaaatga taccgactca gctgttagtg gtcattgcgg 403141 cccagcggga aattgtcccg tttccggctg ttgtggaggc gctgacgatg gaggttgctt 403201 ttgagattct gagggaagcg ggagtcaggc tgccccgggt tgtcggctcg gcagtgtcaa 403261 tcgtaggcgc gctcgtaatc ggccaggctg ccgtacaggc tggtatcgtc tctccggcaa 403321 tggtgattat cgtggcactc accgcgattg cgagcttcgc aacaccggcg tttgcaatgg 403381 cgatttcagc ccggcttatt cggtttatct ttattattgc ctcagctgtt atgggttttt 403441 acgggctgat tttagggatc attatgatgt ttgtccactt atgcagtctt cgttcattcg 403501 gcgttccata tatgtcgccg cttgcacctt tttcttcaca aggcgtaaag gacgcgcttt 403561 tccgggttcc gtggtgggcc gatgaaaaaa ggccggaatc ggtcagcaag gaagataagg 403621 tgcggcaggg gaaagatcaa cgcccagagc cggccgcttc acgaggaatg gtgaacaaag 403681 atttggaaga aggggatcag aatggtacgt aaatgtctat tagccgttct catgcttttg 403741 agcgtcattg tgctgcccgg ctgctgggat aagcgggagc tgacggatct tgcgattatc 403801 tcggcgattg gcatcgatcg gacaaacgac agcaactacg tgctgcatct tcaaattatc 403861 aatccaggaa atgttgccgg cggccttcag ggaggcggtg ctggagacag gccgcctgta 403921 tctgtctatt cgattgaagg taacaatata acggaagcac tcagaaaagc ctccatgaag 403981 gtatcacggc ggctttattt tgcccatacc aatctagtcg tgatcaatga aaagctggca 404041 aaagaagaag gtttggattt tgtattagat aatcttgacc gggacacaga attcaggaca 404101 acagcaacat tcgtcgttgc ccataaaaca aaagcagaaa atattgtgaa aatcttgacg 404161 ccgattgata aaattccgtc aaataaagtc aataaaacac tcgatttcac ggaggcacaa 404221 tacgggcggg tggtcaaaat caatattcag gacgttttga aaacacttgc cgccaacact 404281 atggcaccgg tcatccccgg atatatgatg attggtgacg ataaaaaagg agtcagcatg 404341 gaaaacacgc aggcgactga cccgaaagcc attcttcagg cagatggttt ggcggttttt 404401 gataaggcag gatatttaaa gtattggctg gaagatgatg aaagcgtggg ggcagtctgg 404461 cttatgaata agatccagca tacgtttatt aatgctgact ggggcaagac gaaggatgcg 404521 gtcagcttgc aggttaccca tcaagataca aagctggtac cgaaaatgcg gaacggacgc 404581 ccgtacatcc atgtgaaagt gtcggttgaa ggtattatag atgctgtcaa ataccctttc 404641 caattgtctg atcccaaggt gctggccgct attgaaaaag cgctcaacaa agagcttgaa 404701 aaggaaatca gccatactgt gaaaaagatt aagaagaata aaatagattt tatcggtttt 404761 ggtgacacga tatatagaaa gtatccggag cagtgggaga aaatgaagga cacttgggac 404821 aaagaatatt tgccggaact gcccatcgat gtgaaggccg agacgtatat cagaaggacg 404881 ggattgcgaa acaatccgat caaacaccag tttaaagatg attaggtctg aagaaagggg 404941 aagtgacaga tggaaaaagc cagaataagc ataaggcagt tgtttgtcat gattatcatt 405001 tttgaactgg gcagctcctt attgattaca ccgggatcaa tggcgggcag ggatgcttgg 405061 atagcagttt tattaggctg tgcgatcgga ctgtttcttt tctatttgta tcaaggcatt 405121 tatcaatgtt atccgaattc ttctccgaaa gaatatatgg atgatatgct gggaaccaag 405181 ctgagctggc tgttttcatt tctctatatc ttgtactttg cctatattgc cgcaagggtg 405241 ctgcgtgact ttggagaaat gctgctgacg tttgcttatc atgatacacc tatcattatt 405301 gtaaatgctt tattaatggt agtaagcata tatgccgtaa gaaaaggaat tgaagtactc 405361 gcacgcgcgg ccgaacttct tttcggggcc atgtatttac tgggcgcgat cggccttgtg 405421 ctgattattg tctcagggac tatagacccg cacaatttaa agccggtttt ggcaaacggc 405481 atttctcctg tccttcactc tgttttcaca cagaccatgt acgttccatt tggtgaagtt 405541 gttttatttg tgatgatttt ccctaacctg aatgacagaa aagatgtgaa aaaaatgggg 405601 atgatcgcca tggctattag cggattgatt gtggcgctca ccgtggcgat taatattagc 405661 gtgcttgatg ttgatcttac actcagatcc cagtttccgc ttttaagcac gatccagaca 405721 atcaaggtcg aagaattttt agaccggctc gatgtctttt ttatgctggc gctgatcatc 405781 ggcggcttct ttaaggtcag cctctactta tatgccactg tggttgggac atctacgctc 405841 tttaaggaaa agaacccctc tcaattggct tatccgatgg gattgggcat cttaatcctt 405901 tctataacga tcgcgactaa cttttcggag cacttgaatg aaggcctgaa cgtggtgccg 405961 ctgtatattc atttgccttt tcaattattg tttccgctct ttctgtttat tgtggccgtt 406021 tggaaaaaga aacgaagaga gaagtcaaaa ggggaggaag caaaaaaatg ataaaaagag 406081 cggggggatg cggccgccgc tctttttatg ttcacttcta tataaaaggg ggatataggg 406141 tgcgcccctg tctgcactgg cagaggcgcg ttttgttata cgactgcgac gttttccttc 406201 acagtaaaac ttcctcttga aagtctgata ttgatgtctg acacttttgc aatttgttca 406261 tcgtgcgtca ccataatgac gcatttatct tccttgtgcg ccagatcctg aaagagccgt 406321 acgatctctt ttgatgtgtc ctcatcaagg tttccggtcg gttcatcggc tacgataaga 406381 tccgtgtcac agcagaaagc ccttgtaatt gatacccgct gctgctgtcc gccgctcagt 406441 gtgagcactt tttgccgggc ttgtttttcg ttgatgccaa ccttctgcag catgtcaagc 406501 gcatatgatt ctttgttctt ttctttagaa cctgtgattt ccatagcggt tgtgacgttc 406561 tgcaaagccg tcatatacgg gagcaggttg tacgcctgaa agacgattga tacatattga 406621 tttctgaaat tggttaagcc gattttagaa accgcttttc cgtcgtaaag gatgtttcct 406681 tcttttggtg cgtcaagtcc gcctgccaga gacaggaaag tggttttccc cgtccctgat 406741 gttccgacga ttgtgtagaa ttttcctttt tgaaagctga tgttaatatc ctgaaacaat 406801 ggctggcttt tgtttttata ccagtagccg acttgttgaa attgtaataa gctcataggt 406861 tccgcctctt tctattcctg ttttgtcaat atcgttttcg gatgaagccg cagtactgaa 406921 attgacggca gcaatgttgc aatgattgcg attaggatgc cgatcccgcc aagtataagc 406981 atgtcgttca tagaaaccgc gacgttcagt gaatcgataa cgtccacgtt ggatgaactg 407041 tggccgaaca ttttgccgcc catgccgcca ccgccgccgg gcatttgtcc gcttgcggtt 407101 tgcgttgaat cggttgatga actgatttgc tgggataaaa gctgatttcc aagctgattc 407161 gcgacgagat ttcccgtcac agatgcaagg ccgatagcga taacggccac aatcagaatc 407221 tcagtcaaga actgtccaat caatttccat cgtttttcac cgatggccat taacacgccc 407281 atttcgtatt tgcgctccct gattgacatc atgacaatca ggccaagaat gacggcgcct 407341 gccactgata caagatacac cacgttttta gagaaagaag ccacattttc aatcggtccg 407401 accatttgct ggtaaagctg atcgtttgta ttcagtgtgt acgtatcaaa gtcaattgat 407461 gttttcttcg ctgcttttac gaaagtatcc atatttttcg cgtcgtccat atagtaaaca 407521 gctgagtcaa tcgtattttt atagtcgtcg cctttcaatg ccgctgttgc tgtgtaaggc 407581 gtataaagct tgttataagg atttaagaaa gagaaatttt gggcttggtc atcacctgaa 407641 gatgttgttt tataaatacc gacgatcttc agttttactg ttgtatcctc atccgttgct 407701 gattcaattg tgatcgaatc gccaacgctt aaatcatttt cttccgctaa tgtttcgttg 407761 atcactgtta cttttttgcc gacatctgat tttgtaatcg cgcgtccgtc tgtgattttt 407821 gaatctccgt cagagaaatc atcgactaac gctgtgctga tgacaccttc aatagaaaga 407881 tcagcttgaa ccatttgcgg tccgccttgt cctccgcctt gactgttttt agcgtttgag 407941 cttgaactgc tggagctgga atcacttgaa ctagagcttt caatcgcatc aaagtttccc 408001 gcgttggctg aagctgatgt ggtgtaattg tagctcttca catgatcaag cgctgcaagc 408061 ttattcgcat cagacacttt gatcggtgtg gattcgaagc tgcgcttttc accgctgtcc 408121 tgctgttttt ccatttgctt ttggcggtca acctgaagtg tcacgcttcc accgagttcc 408181 tgtctggcca gttcgcttga cttttgtgct gccgactgga tggcgaggcc tgatagaaca 408241 aagacacata tgactgtaaa cacaaataat tgcaataacg tttttccctt tttagccttc 408301 atattccaaa aggcccgttt gataaagttc atttatgttc ctccgtatag gtatttttat 408361 tgataagacc gcctctgggg cgcgtcccct tgctgataaa ttaatagtag tccaaaggta 408421 tgaaaaaaat atgaacaatc tatttctagt tgatgaaata aaaactaaca attgtgaaac 408481 gcaaaacctt ctgtttaaaa tggtgctatt atataaaaaa gcatcaaaac aaccggagga 408541 tataatgaaa atattaatga tagaagataa tgttagtgta tgtacgatga cggagatgtt 408601 cttttttaaa gaaggttttg aagccgaatt cgttcatgac gggttagaag ggtaccagcg 408661 ttttacggaa gaaaattggg atctaatcat tttggatatc atgcttccat ctatggacgg 408721 cgtgaccatc tgcagaaaaa taagagagac aagcacggtg ccgattatca tgctgactgc 408781 caaagacact gaatcagatc aggtcatcgg ttttgagatg ggggcggacg attatgtcac 408841 aaagccgttc agcccgctga cattggttgc ccgcatcaaa gccgtcatca gaagatataa 408901 ggcgacaggc aaagcggtta ttgatgaaga tatgattgaa acggaatgct ttaccattaa 408961 taagaagacg agagaagtat tattaaacgg agagcctgta gaaaatctca cgccgaagga 409021 attcgatctg ctttattacc ttgtccaaaa tccgcggcag gtgttctcca gagaacagct 409081 gcttgagcag gtatggggct atcaatttta tggagatgag cgaacggttg acgttcatat 409141 caaacggctg cggaaaaagc ttgccagcga ggacaagcct ttcctgtata ctgtgtgggg 409201 agtagggtat aaatttgatg aagattaaat atttatatca gctgctgcta agccatatca 409261 gcattttgat tttagcgttt gtcattatca tttctctgtt ttcccacttt gtgaaggaat 409321 ttgcctatca gaacaaagta gaggaattga cgtcatatgc ggtgcagatt gcaaatgaat 409381 tccaatccgg ccaggtggac atgcgcaggc tctatcctta tcaggacatt ttaagcacaa 409441 gaaagacgca atttatcatc tttaatgaag agcagcagcc ttattttctt cctgaaggct 409501 ttcatcaccc accaagggaa cagctgaaga aatcagaatg gaataagctg aaaaaagggc 409561 agactgtcac gatcagggca gatggccgtt ttgatgatga agtgtccctt gtggcgcagc 409621 ctatatttgt tcagaacgaa tttaaaggcg ccgttctgct gatttctccg atcagcggtg 409681 ttgaacagat ggtcaatcag gtcaacctct atatgtttta cgctgtgatc agcacgcttg 409741 tgattacgat tcttgtgagc tggcttctgt ccaaattcca tgtcaagcgg attcaaaagc 409801 tgagagaagc gacagataaa gtggcttccg gcgattatga catccatttg gaaaacagct 409861 acggggacga aatcggcgta ctggcgtctg actttaatat catggcgaaa aaactaaagc 409921 agtcaaggga tgaaatcgag cgccttgaga agcggagaag gcagtttatc gctgacgtgt 409981 cacatgaatt aaaaacaccg ctgacgacga tcaacggttt ggttgaaggg ttgaacagcc 410041 atacgattcc tgaggataaa aaggataaat gcttctcgct gatcagtgag gaaacgaagc 410101 gcatgctgcg gctcgtaaaa gaaaatctgg attatgaaaa aatcagatcc cagcaaatta 410161 ccttgaacaa gctagacgtt cctctgatcg aggtgtttga aatcgtgaaa gagcacttgc 410221 agcagcaggc ggaagaaaaa caaaacaagc tgatgatcca agtagaggat cacgtcatcg 410281 tacatgccga ttatgaccgg ttcattcaaa ttctcgtcaa cattacgaaa aacagcatcc 410341 aatttacgca aaacggtgac atttggctgc gcggaatgga aggttataaa gagacgatta 410401 ttgaaattga agacacgggt atcggcattc caaaagagga tattgagcat atttgggagc 410461 gattctataa agcagatatt tcaagaacga acacagcata cggtgaatac ggactcggtc 410521 tctcgatcgt caggcagctc gttgaaatgc accagggcac agtagaaatc aagagtgaag 410581 aagggaaagg cacaaagttc atcatccgcc ttcctttaac ggcaaaacag caatagcata 410641 cagggcggcg catcaactga tgcatccgcc ttttttgcac accgcttcgg tttattgcgt 410701 gctcccgaaa acaaagattg cgtgtttttc gggttgggac ggcctataaa catgataaaa 410761 tatgacataa acagtttttg atgggagagg gtgaaggaat gaagagtggg gtaattcctt 410821 cttcagcggt cggtcaaaaa attaacgagt ggtacagata tatccggaca ttcagcgtgc 410881 cggatgccga agtgttaaaa gctgaaatcc agcaggaact gaaacacatg cagcatgatt 410941 ccaacttgct gctttattat tcactaatgg aattccggca ccagcttatg ctggattatc 411001 ttgagccgtt agagaaatta aatatcgaag accagccaag cctgtctgaa ttatcaagaa 411061 acattgacag caaccaggca gatctcaaag ggctgctcga ctattacgtg aatttttttc 411121 gcgggatgta tgaatttgat aagcgggaat ttatttctgc cattacatac tataaacagg 411181 cggagaaaaa gctctccttt gtcgcagacc atattgaacg ggctgaattc tattttaaaa 411241 tcgcggaagc ttattattat atgaagcaaa cgtatttttc attgattaat ataaaaaacg 411301 cctatgaaat ttacgtggag caggaaacct ataatgtgag aatcattcag tgccatttcg 411361 tcttcggggt caacctgatg gatgaaagaa atttcgaaca agccgcacgc catttcaaat 411421 tggcgctcaa catggcccaa gcagaacaaa aagcccagct ggttggaaga gcatactaca 411481 atctcgggtt atgctattac aatcaagacc ttctagaccc tgccattgat tactttgaaa 411541 aagcggtctc cacatttgaa agcagcagga tcgtcaattc tctcccgcaa gcctattttt 411601 taatcaccct gatttattat aaacagggaa aacatgataa agcttcggaa tatcacaagc 411661 ggggctatga atatgctaaa gaaacagacg atgcagacta tgccgtaaaa ttcgagtttt 411721 tgcaatccct atatctggat cagcccaatg aagaaggaat cgaacgatgt ttccagtact 411781 taaaaaataa aaatatgtac gctgatatag aggatttagc cctagaagta gcaaaatatt 411841 actatgaaca gaaatggttt aaactgtctg cttcctactt tctacaagtt gaagaggcaa 411901 gaaaacaaat acaaaggagt gaaggtttgt atgaaattga aatctaagtt gtttgttatt 411961 tgtttggccg cagccgcgat ttttacagcg gctggcgttt ctgctaatgc ggaagcactc 412021 gactttcatg tgacagaaag aggaatgacg taagaacaag ccccttctca ttagcgagaa 412081 ggggtttttc ttttcaaaaa aacaccgcaa gacatagtct tgcggtgccg ccttcatgga 412141 gattacgttt atttagtagc ctcctacaaa tgcagttccc acaatgatca agaggataaa 412201 taacacaaca atcaaagcga aagaagttcc gtaacctgac attttgtgca cctccttgcg 412261 agattgcttc agcaaatgct gcaaaactgt ggcggacagg gtcccgcaga gacggtcagc 412321 agcttagaag ccgccaacaa acgcagtccc tacgataatt aatagaataa acaatacaac 412381 gattaaagcg aaagaactga tgccgccgta accgccgccg ttagagtatc ctgacataag 412441 gtttcacctc cctatgaagg atactataag atatgctgaa ccgatccatt tggcagggat 412501 aatagtggac aagagaaaaa atgaagaatt cggctatatg aaggtgatat aaaaaaatag 412561 cgggcgctgc cgcccgctat ttatgtacga ttaagagatc agcacgcccg cgaaaaattc 412621 ctggtataac gcttgaacgg cttttctttc ttcggcttct tttacgccaa acatcatgct 412681 cacttcagaa gacccctgat tgatcatttc gatattcacc tgtgcctctg ataatgcttt 412741 ggcggctctt gccgttgtac cgacattgtg gcgcatcgct tcccctacaa ccataatcag 412801 ggcgagatga tgctcgacga tgacttcatc ggcatgcaaa tcctcttcga tccgtttgat 412861 gacgctgcgt tcagtggcgg catccatttg cccctgccgt aaaatgattg tcatgtcatc 412921 gattcccgat ggaacatgct catacgtcaa accatgctcc tccaggattt gaagggctct 412981 gcggccaaaa ccgatttctc tgttcatgag atacttgctg atataaatgc tgcaaaaacc 413041 ggtgtcgctg gcaatgccga cgacaggccc gtttgtgtta tcccgcttgc tgacgacgcg 413101 ggtgccttcg gctgaggggt tgttcgtatt tttgatctga acaggaatcc ccgctctgaa 413161 tgccggaatg agcgcttcat catgaaacac tgaaaaaccc gcgtaggaca gctcccgcat 413221 ctctctatat gtcagctcgc tgatttcctt tggattctca acgaaggacg gattgacaga 413281 atacacagcg tctacgtctg taaagttttc gtacaaatcg gcttgtagtc cgttggcaag 413341 aatcgaaccg gtaatatcag aaccgctccg tgagaatgtg atcacatcgc catccttgct 413401 gaatccgaaa aaaccgggaa aaatgatgag tccgtcacgt tcccgaagac gatagaggtt 413461 ttgataggat tcaggaagaa cttgcgcgtt gccgggttca tttgtcacaa agaggccggc 413521 atccttcggg tttacatatt ccgctttgac gcctttataa cggaagtaag cggcgatcag 413581 tttggcattg ttatcctctc cgctggcctt gactgcgtca aggtattgtt cgggattgct 413641 tttgtctcct tctaaaagcg taaacagatc atctctgatt ttttcgataa tgctttgccc 413701 cagctgaagc tcattggcga tgagagcgta ccgttccaca acagcttccg ccagttcagg 413761 tgcgctgcct gttgccaaat attgttctgc acatgcgatt aagagatcag tcactttcgt 413821 atcctcggca tagtgttttc ccggagctga aacgactaca gctttccgtg ccggatctga 413881 ggtaacgatg tgaaacacct tgtcaagctg ggcgcctgaa gcaagtgagc tgcctccgaa 413941 tttaacgacc ttcatgttta catctcctaa tgtttaaaat tttcacacaa atttagtatt 414001 tattatctct ctttcagtac tgtaaatcaa gggggaattt ctttctcagg agaacatttg 414061 tatttttcac gaggaataat gttaggtttg ctgaccgtat gcctgcgtta taaagataaa 414121 tatggtaaac agcctaacgt tttgggatgg aaaatggtta gaatgattag taaaattgat 414181 aaatgactag gttaatattt ttaaagaata ttgactaacc ctataaaaat ggtaatatgt 414241 aaatgataat gataatcaat tactatatgg ccatattgtt ttgagtcctt gcggagtagg 414301 agatacgttc tttttgctgt aaggatgtaa ggaggcagca tgaagctacg ttacttattt 414361 attctactta tcatattagc agtcacatct gtatttatcg gtgtagaaga tctgtcgccg 414421 cttgatctct tcgatttaag caaacaagag gcgtcaacgc tgtttgcaag ccgtttgccg 414481 cgattgatca gcattgtcat tgcgggatta agcatgagca tctgcggttt gattatgcag 414541 cagatcagca gaaataaatt cgtgtcaccg acgacggcgg gcacgatgga ttgggcgagg 414601 ctcggcattt taatttcctt gctgctgttt acatccgcca gtcctttaat caaaatgctg 414661 gtcgcgtttg tctttgccct tgcaggaaat tttctgttta tgaaaatcct tgaaagaatc 414721 aagtttaacg acaccatctt tattccgctt gtcggtttaa tgctcgggaa tatcgtcagt 414781 tcaatcgcga catttatcgc atataaatat gacttgatcc agaatgtgtc atcatggctg 414841 cagggagact tctctttagt cgtgaaagga agatacgagc ttctttatct gagtattccg 414901 ctcgtcatca ttgcctatgt gtatgcggat aaattcacat tggccggtat gggtgaaagc 414961 ttttctgtca acctcggcct caagtataaa cgggttgtga acatcgggct cattatcgtg 415021 tccctgatca cgtctcttgt cattttgact gtcggtatgc tgccgtttct cggtttaatc 415081 atcccgaata ttgtatcgat ttacagagga gacaatctga agagcagcct gccgcatact 415141 gtgctgttgg gagcggtttt tgtgctgttt tgcgatatac tgggcagaat cattatcttc 415201 ccttatgaaa tctcgattgg cctgatggtc ggaatcatcg gcagcggcat tttcctgttt 415261 atgctgttaa ggagaaaagc ctatgcgtaa ccagatgaaa atagctttgc tcgttggttt 415321 agccattgta tgtattggct tgtttttgtt ttatgactta ggcaattggg attacaccct 415381 gccgagacga atcaaaaaag tcgctgccat tgtgctgact gggggagcga ttgcgttttc 415441 gaccatgatc tttcaaacga ttacgaacaa ccgcatcctg acgccgagca ttttgggcct 415501 tgattctctc tacatgctga ttcagactgg cattatcttt ttgttcggtt ctgcgaatat 415561 ggtcatcatg aataaaaaca tcaactttat catctctgtt ctgctgatga tcctgttttc 415621 tcttgttttg tatcagatca tgttcaaggg tgaggggaga aatatctttt tccttctgct 415681 tatcggaatc gtgtttggca cgctgttcag cagcctgtct tcttttatgc agatgctgat 415741 tgatccgaac gagttccaag ttgtgcagga caagatgttt gccagcttta acaatatcaa 415801 tacggatttg ttatggctcg cgttcatcat cttcctgctg acaggcgttt atgtctggcg 415861 ttttacaaaa tttttcgatg tgctgtcgct cggacgcgag cacgccgtga atttgggcat 415921 tgactacgac aaagtggtga agcagatgct gatcgtggtt gcgattttgg tttctgtttc 415981 aacagcgcta gtcgggccga ttatgttttt aggccttctg gtcgtcaacc tggcgagaga 416041 attcctgaaa acatataagc attcatactt aatcgcaggc tccgttttca tcagcatcat 416101 tgcgctggtc ggagggcagt ttgtggttga gaaagtgttt accttctcaa cgacgctgag 416161 cgtcattatt aattttgccg gcgggattta ttttatctac ttgctgttaa aggagaataa 416221 atcatggtag aggtcagaaa tgtaagcaaa caatatggcg ggaaagttgt tcttgaagag 416281 acgtcagtca cgattcaaaa gggcaaaatc acctcgttta tcggtcctaa cggcgccggc 416341 aaaagtacgc tgctgtctat catgagccgc ctgatcaaaa aggattccgg cgagatttac 416401 atagacggac aagagattgg agcatgtgac agcaaagagc ttgccaagaa aatgagcatt 416461 ttgaagcagg cgaaccaaat caatatcagg ctcacgatca aagacctcgt cagttttggc 416521 aggtttccgt actcacaggg ccggctgaca gaggaagact gggttcatat caaccaggcg 416581 cttagctata tgaagctgga agacattcaa gacaaatact tggatcagct gagcggcgga 416641 cagtgccaaa gggcatttat cgccatggtc attgcccagg acacagatta tatctttctg 416701 gatgaaccgc tgaacaatct ggatatgaaa cactcagttg aaattatgaa actgctgaaa 416761 cggctggtag aggagcttgg aaaaacgatc gtgatcgtca ttcacgatat caattttgct 416821 tcagtctatt ctgactatat cgtcgctttg aaaaacggcc gaatcgttaa agaaggaccg 416881 cctgaagaaa tgatagaaac atcagtgctt gaggaaatct acgatatgac catcccgatt 416941 cagacgattg ataatcaaag aataggtgtt tatttttctt aatatataga agaggtgagg 417001 agcatgaaaa agttcgcgtt actattcatc gctttggtca ctgccgttgt catttctgca 417061 tgcggaaacc aaagcacaag cagcaaaggt tctgatacaa agaaagaaca aatcacagtg 417121 aaacaccagc tcgacaaaaa cggcacaaaa gtaccgaaga accctaaaaa agttgtcgta 417181 tttgactttg gaagcttaga tacattagat aaactaggac ttgatgatat agtagcgggc 417241 ctgccgaaac aagtccttcc taaatatctg tccaaattca aggatgacaa atacgctgat 417301 gtcggcagct taaaagagcc agacttcgac aaagtggcag aattagatcc tgatctgatc 417361 attatttcag caagacaatc tgagtcttac aaagaattct ctaaaattgc gccgacgatt 417421 taccttggtg tagatacagc gaagtacatg gaatcattta aatcagacgc tgaaacaatc 417481 ggtaaaatct ttgataaaga agacaaagtg aaagatgagc tcgcaaacat tgatcactca 417541 atcgcagatg taaagaaaac cgctgaaaag cttaacaaaa acggtctcgt catcatggcg 417601 aacgatggaa aaatcagcgc gttcggccct aaatcaagat acggcctgat ccatgacgta 417661 ttcggcgtgg ctccggctga tcaaaacatc aaagcgtcta cgcacggaca aagtgtttct 417721 tacgagtaca tttcaaaaac aaaccctgat tacttgtttg ttattgaccg cggtacagca 417781 atcggagaaa catcatctac aaaacaagtc gtggaaaacg attatgtgaa aaacgtaaac 417841 gcagtgaaaa atggtcatgt catctacctt gattctgcta cttggtattt atcaggaggc 417901 ggacttgagt ctatgacgca aatgattaaa gaagtgaaag acggtttaga aaagtaaaac 417961 caaaaagagc ctccgctaaa tagcggggct ctttttttgt taatcagcgt gccggctgct 418021 gttcggcagg gcgctgaggt ttctttaatg tgaatgagag aaggaagccg acaagtgcaa 418081 tgacggcagc cactataaaa gcggcgttca tgccgtgcag ggcggcgtgc ttcacatttg 418141 tcgtgcctgc atgtgccgcc tggttgctca tcacggaaac caatagtgcg gttccgatcg 418201 agccgccgac ttggcgaatc gtgttgttca tcgcagttcc gtgcggaatc aagtggcgcg 418261 gcagcgcatt gattccggct gttgtcaccg gcatcatgat catggcggtg cctaagagac 418321 gaacggtgta taaaacgaca atccaagcga gtgacgtatg gtcagtcagc tgcataaacg 418381 gcagagatgt caggaagatg atgcagaaac cggcaatcgc cagccctctt ccgccgacac 418441 ggtcaaaaat tctgccgata atcggcgaca taaagcccat cacaacggct cccggcagga 418501 gcataagccc tgtatcaaaa gctgtgacgt ctctgacatt ttgtgtataa agcggcagga 418561 tggtttccgt accgatcaat aatgcaaaga cgagggttcc cagcagtgtt gttaagctga 418621 aaacgccaaa cgtgaagacg cggaattcca gcatcggttt tttaagcttc atttgtcttg 418681 tgataaacaa gagcagcgcg atgacaccca ccagcagtga aatcaagacg gttgaactgg 418741 accagccata agagccgacg cttgagaagc cgtacagaag gccgccgaac ccaaatgttg 418801 aaaggatgac tgataaaata tcaatctgtg tttttcttaa agtcgtcacg tttttcatca 418861 ggatgctggc aagaatcaaa tcaatcacag caaacggaag aataatataa aacaatgatc 418921 tccaagagaa agcttcgaca gcccatccgg aaagagtcgg tccgatcgca ggcgcgaatg 418981 agatgaccaa tccgaccata cccatagcct ggccgcgctt ttcaatcgga aagattgtca 419041 ggaatacagt ctgcatgagc ggcatcataa tgccggctcc agccgcttga atgatacgcg 419101 ctgtcagcag aaccgggaag ttcggcgcga acgctccgac gactgttccg gcagtgaaaa 419161 tgctcattgc tgtgatgagc agcgcccggc ttgtgaattt ctcaattaaa aacgcggtaa 419221 tcggaattaa aatcccgttg gttaacataa atgatgttgt cagccattgt gcttggttgg 419281 catcgacatt gaaatccctc atgatatggg gaagtgcagt aatcaacaat gtctggttca 419341 aaatcgccac aaacgctccg gctaacaaaa tgccgacaat gacagaacgg ttaaaaggtt 419401 tttgttcaat acttgtgttc aatacatatc ccttcttttc tctaagtaat taacagtgtt 419461 tttaacatgg aaacgggctg tgttaaaaca ccggtttgtt ccagatagcc aatcagtgat 419521 ttgagtaaaa aagcgcgggg ttcttccttc ttcgcttctt cctccagcat agcggctgcg 419581 gatgtcagtt catctacgtc atagtccgcg gcggacaggg aagagatgcc tttatgtaat 419641 tccttcaggc tttccgataa taggactgat ttatcctttg gcttgtagga ggatgctgaa 419701 tgaatataaa gctcgatggc ttcgggcgga agaagagact ggcgggtttc cctgtttttg 419761 ataatctgat tgagggtgct gatgataaac tctgcgatcg ggtcaagctc aagcggtttt 419821 tcctcgattt tgatcagcat taaaaactca cgcatcatgc cgtgaagaat gataaccaaa 419881 tcccacacaa acgggagaat ggtttctcca tacgcctgga tcagcgaatc gcggtgccag 419941 cagataatcg tcgatctggt ctgatggata tgctgtttga cccggtcatt gtgcagcttg 420001 gggtttccgt aggtcagcat attgaaaaac tgctgattcc gcctgaagcc ctccagttcc 420061 attttgacct tttgcgtcaa acgctcctcc ggtgtaagtg ctgtattttc ctgaagtctt 420121 gaggccgcgg ccaccatttg cttctggtta aatgacagca gctccaaaag cagatcttct 420181 ttagattgga acagcttata tatcgaagct tttgacatct tacattcttc tgcgatcgcc 420241 tgcatggaaa ccgacgtaaa atccttttcc gaaaaaagct ttcgcgcggc taacaagata 420301 tctgtttttt tatcaagcat ctcatggctt ccttctttct tgaacattag aaaacccatt 420361 ggttcacaga aaaccaatga gtaacaatga aaaaatttta ccagataaac aaaatagaag 420421 tcaatggatt ttaaccgggt aaatgaaagg cctgccggaa aatccgacag gccgaataag 420481 agcttatttt tcaactttaa atccttgttt ttcaagcatt tcacggatgt gcggatagta 420541 caggcgctca tagtaggaag cgatgctctg tgaccagttt cttgtttctt ttccgtttgt 420601 ccgtttattc atgtattcag acatctgttc gtcgtatgcc tgaatgtgag acgtcagctc 420661 atcctgattc aaataagttt cctgatgatt gacagcttcc tgcggcaagc gcggtttttt 420721 cgctgaacgg tcggcaggat gcccaatgac aaggccggat aaagggaaca cgtatttcgg 420781 aagctcaagc agttcgatca gctcttgagg gtttccgcga actgcaccga tcggaactgt 420841 gccaagtccg agtgactcag ccgctgctgt tgctgtgccg agggcaatac cagcgtctac 420901 tgcgccgaca agaacagatt ccaatccatt tgtgatttcc attttgaaat catgcagatc 420961 ttcaagcgca attttggccc ggttaaaatc tgcgcagaac agcaggaaaa caggagcttg 421021 atcgatccat ggctggccgc ctgccagctc ggagattttc tttttgcgct ctttatcctg 421081 gactgtgatc acagtcactt gctgtccgtt gatagaagaa ggggctgatt gcaccgcttc 421141 aatgatttgg tccaattgct cctgagctac aggctcatct gtgtagctgc gaatcgagcg 421201 gtggtctgtt aaagatttaa tcacttcatt catatgagac acccttcctt tactcgctaa 421261 gctctgtgcg gacaacatca agaggagcgc tcagcagttc ttttcctttt gcgacaaacc 421321 cttggaaatg cgcagtttcg ttatggaatt tcattgccgc ttcatctttc catttttcaa 421381 gcatgacaaa tgtattttct tcgcctactt tttcgaatag gtcgtattgc gcgttgcctt 421441 cctcagctct tgaatgctga acaagtgatt gagcctcgct caaaaattcc tcgcgttttt 421501 ctggttttac tttgatgtaa gcttgtaata cgatcatgta aatctcctcc gtcgttatgc 421561 gaatttattg ttcgaatttc atcgaactaa atgtaacatg tattctaaat gaggtaaagg 421621 aaaaaccctt atatagtaaa attgtcattc taattgttgt atgatacatt tgtgtcatga 421681 acattccaaa ccatccagaa acagaaacat tgcagctgac aaaggttctt catgcactta 421741 gtgatccgct tcgtttagag ctcgtcaagc aattagctga agcaaaagaa aaaacgtgca 421801 gcacctgtgc agatgtgcag gttgccaaat cgactttgtc gcatcatttt aaagttttga 421861 gagaatcagg catcgctcaa gttcggatag aaggaaagcg ccggtattat tcgcttcgcg 421921 ctgaagacct tgaaaaggca tttccgggac tgcttgaagc cgtgctgaat gtagaccagg 421981 accgctggtg aatcaatccc ctgtaacggg gattttttta tgtccgtaaa ccgctttgaa 422041 aagccgctgc acaccctcct gaatatcttc ttccttcagc cgtgcaaagc cgataatgag 422101 agcaggcctg cccgtttgcc gcttgttttc cttcaagtta aatcggctca ttccgaatat 422161 ttcaagctgc agcccggcag catgtgacag gatgtcttgt tcggtgcgcc tggtatcaaa 422221 ttcggtaaca aaatgcagcc ccgcatttgc cccttttacg gtaacctctc cgctgaactc 422281 tgcttctaaa gcggtgatca ggcgttctct cttttcttta taatgctgct tcattttttt 422341 tatatgcttc tgatattcac cagactcgat aaattcctgc agggtgagct gtgtgagtga 422401 tgagcaagtc tgcagatcat agccccgctg tttgtatgcc ctcaacagct caggcggcaa 422461 caccatatag ctgatccgta agccggggag aagggacttt gaaaaggttc ccatatagat 422521 gacattttga aaacggtcga ggctttgcag cgccggaata ctgtctacat catatgtgaa 422581 ttcactatca taatcgtcct caatgatata tcggcgcggc tcctcggctg cccagttcag 422641 cagctgaatt cttctggata caggcataat cgttccggac ggaaactgat gcgacggggt 422701 ggtcaccagc acatctggct gctgtctggt gatttcagca atcgacatgc ctttttcatc 422761 cagcatgatc gtctttactt gttttccggc attcttcaaa agctgataca tgcgcctgta 422821 gccaggctcc tccatcgcat acacggcttc cttgggtaaa agctcagtca acagctgcat 422881 gagcacctgt gtgcctgccc ctatgatcat ttgttccggc ctgcatttta cacccctcgt 422941 cagggaaatg agcctcgtaa tggccgctct cacttcatat atcccttgcg gatgtgacat 423001 atcgccgagc gtgcggtatg agcgggaggc cgctttttgc tcgcagcgga accagctttt 423061 gatcggaaaa tggtctgtat cggaactcat gtgtgaaaac gatatccaat cgctctggtc 423121 gatgtgaatc tcttttaggt catccggcag tgcaaatgga gggtgctcct cggcggaaaa 423181 catgtctagt tcctccacga agaaaccctt tcgttcaatg gcgtacaaat acccctcagc 423241 cagcagctgc tgataggctg aattcactga atttacgctg accttgagat tttcagccag 423301 ctcccgcttg gagggaacct tcgagtgcgg cagcagattg cggctgagga tttctttttt 423361 cagcttttga taaatttgct gatagatata atcggcttgt tctgaacgat cgagtgtaat 423421 cgtgatatcc attttgtagt ttctccttct gataccatca aaaagttata attggtactt 423481 ttcatcatac caaagagaag tcagaatgat aagaaaatac cgacaggggg atattcacat 423541 gagtcaaaca acagcaagca tcacaactgc acaatggcag caaaaacggg atcaatttgt 423601 gtcaaaaggt gtgagcaacg gcaaccgcag tctggcggtc aaaggagaag gggccgagct 423661 gtacgatctg gatggccgga gatttattga ttttgcaggc gccatcggca cgttaaatgt 423721 cggacactcg catccgaagg tggttgaggc tgtgaagcgg caggcggagg agctgattca 423781 tcctggtttt aatgtcatga tgtacccgac ttatatcgaa ttagcagaaa aactgtgcgg 423841 catcgcgccg ggcagccatg agaaaaaagc gatttttctt aactcagggg cagaagcggt 423901 cgaaaacgct gtgaaaatcg ccagaaagta tacaaagcgc caaggcgttg tctcgtttac 423961 acgcgggttt cacgggcgca cgaatatgac gatgagcatg acaagcaagg taaaacctta 424021 taaattcggt ttcgggcctt ttgcgccaga ggtttatcaa gcgccgttcc cttattatta 424081 tcagaagccg gccggcatga gtgatgaaag ctatgacgat atggtcattc aagcattcaa 424141 tgatttcttt atcgcttcag tggcgcctga aacggtggcg tgtgtcgtga tggagccagt 424201 gcagggagaa ggcggattta ttattccttc gaaacggttc gtacagcacg tcgcttcatt 424261 ctgcaaagaa cacggcattg tttttgttgc tgatgaaatc caaaccggct ttgccagaac 424321 tggcacttat ttcgcaattg agcactttga tgtagtgccc gatctgatca cggtttctaa 424381 atcgcttgcg gcaggcctgc cattaagcgg tgtgatcggg cgtgcggaaa tgcttgatgc 424441 ggcagcgcca ggggagctgg gcggcacgta tgccggcagc ccgctcggct gcgcggcggc 424501 tttggcagtc ttggatatta tcgaagaaga aggactgaat gagcgatctg aagaaattgg 424561 caaaatcatt gaagacaagg cgtatgagtg gaaacaagaa ttcccgttca tcggtgacat 424621 ccgcagactc ggggcgatgg ccgcaatcga aatcgtcaag gatcctgaca cgcgtgagcc 424681 tgataagaca aaagcagcag cgatcgcggc ctatgcgaat caaaacggat tacttttgct 424741 gacagcggga attaacggta atatcatccg ctttttgaca ccgctcgtca tctcagacag 424801 cctattaaat gaagggctca gcatcttgga ggcgggcctg cgagcttaat cattggaaag 424861 aaaatggccg ggtctgctat cattttaagt aatcatgaaa agaaaggaat gttcaatatg 424921 ccagatcaat taacggtcta caacccggct acgggcgagg agatcaaaac gattcctcag 424981 caatcagcca cagaggtaga agaagccatt gaacgttcac atcaagcgtt taaaacgtgg 425041 tctaaaacat cagcgaacga aagaacgtct cttttgaaaa aatggtatga gctgattgtt 425101 gaacataaag aagagcttgc agatttaatt acaaaggaaa acggaaaacc ataccaggaa 425161 gcagtcggcg aggtacttta cggcgcaggc tatatcgaat ggttcgcaga ggaagcgaag 425221 cgtgtgtacg gaagaacggt cccggccccg acaactggta aacgaattgt tgtcacacgc 425281 cagccggtcg gccccgttgc tgctatcacg ccctggaatt tcccgaatgc gatgattaca 425341 cgcaaagcgg cgcctgctct tgccgccggc tgtacattta tcatcaagcc ggcgccggac 425401 acaccgctgt ctgcttatga actagcgcgc ctcgcatatg aagcgggcat tccgaaggat 425461 gttcttcagg ttgtgatcgg cgatggagaa gaaatcggaa atgtgttcac aagcagtccg 425521 aaaatccgca aaatcacgtt cacaggctca acacctgtag ggaaaatcct tatgaaaaac 425581 agcgctgaca ccgtaaagca cgtctcaatg gagctcggcg gacacgcccc gctgatcgta 425641 gatgaagatg cggacattga ccttgccgtt gaacaggcga tggcgtccaa ataccgaaac 425701 gccggccaaa cctgcgtatg tgccaaccgc ctgatcgttc atgaatccat taaagatgaa 425761 tttgctgcga aactgagcga gcaagtgtct aagctgaaag tcggaaatgg acttgaggaa 425821 ggcgtcaatg tcggcccgat tatcaacaaa cgaggcttcg aaaaaatcgt cagccaaata 425881 gatgatgcgg ttgaaaaagg cgcgaaagtg attgctgggg gcacatatga ccgaaacgat 425941 gacaaagggt gctactttgt gaatccgaca gtgctcaccg atgtcgatac gtccatgaac 426001 atcatgcatg aggaaacatt cggcccggtc gccccgatcg tcacgttttc tgatattgat 426061 gaagcgattc agcttgccaa cgatacaccg tatggcttgg ctgcttactt cttcacagaa 426121 aactaccgcc gcggcatcta tatttccgag aatctagagt atggcattat cggctggaat 426181 gacggcggac cgtcagcggt tcaagcgcca ttcggcggaa tgaaagaaag cggcatcggc 426241 cgtgaaggcg gttcagaagg tatcgagccg taccttgaaa caaaatattt gtccatcggt 426301 ttataaaaga atgcacgctc ctgagagctg ccggattttc cggcagctct ttttgtgttc 426361 cggcgaataa tcacaacaat tccagccaaa ataacagcaa atacattttg aaagaaggtt 426421 ccccaacaat ggatttatta ttggctcttc tcccggcttt gttttggggg agcattgttc 426481 tcttcaatgt gaaattaggc ggcgggccgt acagccagac actgggaacg acgatcgggg 426541 cactcattgt ttctatcgtt atttactttt ttgttcagcc cgttctgtcc cttcgcattt 426601 ttattgttgg aatcgtatcc ggcttatttt ggtcacttgg acaggccaac cagttgaaaa 426661 gcattcaatt gatgggcgtg tcgaaaacaa tgccgatttc cacaggaatg cagctcgttt 426721 ccacctcgct gttcggtgtg atcgtgttcc gcgaatggtc aacaccgatt gcgattacgc 426781 ttggcgttct cgctttgatc tttatcattg tgggaatcat tctcacgtcc ttggaagata 426841 agaatgataa aaaagagggc gagccaagca atttgaaaaa gggcattttg attctccttg 426901 tttcgactct tggttatttg gtttatgtag tcgtggctag attattcaat gtgtccggct 426961 ggtccgcgct gctgccacag gcaattggca tggtggtcgg ggggttagtt ttaacctata 427021 gacacaaacc ctttaacaag tatgcgatca gaaatattct cccagggtta atctgggcag 427081 gcggaaatat gtttttgttt atttctcagc cgcgagtcgg cgttgcaacg agcttttccc 427141 tttcacaaat gggaattgtc atttctacgc tcggcggtat tttcatcctg cgtgaaaaga 427201 aaacgaaacg ccagctaata gcaattgcga tcgggattat cctgattatt gccgccgccg 427261 tattcttagg aatcgccaaa acaaattcat aacaaatgga ggaggatgta tatgtatccg 427321 gatttaaaag gaaaagtcgt cgctattaca ggagctgctt cagggctcgg aaaggcgatg 427381 gccattcgct tcggcaagga gcaggcaaaa gtggttatca actattatag taataaacaa 427441 gatccgaacg aggtaaaaga agaggtcatc aaggcgggcg gtgaagctgt tgtcgtccaa 427501 ggagatgtca cgaaagagga agatgtaaaa aatatcgtgc aaacggcaat taaggagttc 427561 ggcacactcg atattatgat taataatgcc ggtcttgaaa atcctgtgcc atctcacgaa 427621 atgccgctca aggattggga taaagtcatc ggcacgaact taacgggtgc ctttttagga 427681 agccgtgaag cgattaaata tttcgtagaa aacgatatca agggaaatgt cattaacatg 427741 tccagtgtgc acgaagtgat tccttggccg ttatttgtcc actatgcggc aagtaaaggc 427801 gggataaagc tgatgacaga aacattagcg ttggaatacg cgccgaaggg cattcgcgtc 427861 aataatattg ggccaggtgc gatcaacacg ccaatcaatg ctgaaaaatt cgctgaccct 427921 aaacagaaag ctgatgtaga aagcatgatt ccaatgggat atatcggcga accggaggag 427981 atcgccgcag tagcagcctg gcttgcttcg aaggaagcca gctacgtcac aggcatcacg 428041 ttattcgcgg acggcggtat gacacaatat ccttcattcc aggcaggccg cggttaaaca 428101 taaaaagcga cccagacatg acatctggat cgctttcttt attaggcacg ctttttcttt 428161 acaagtgctg ctacagataa aataatggca gccgcagaca gcaccatcgc tgtaatgtct 428221 agagctgaag aacctgagtt ttcggaatcg tcttctgttt tcgtggcgcc gtgctcatct 428281 gtcacttgct ttgcagacgt gatgtttgta atggaatgag gtgtatcggc atcctcgtca 428341 cctgtccact caacaatgct gccgtctttg taatattggt atgcgtccca agcagcttcc 428401 tccgctttgt cagggttttt ggcaacaaag gtaaactgct ggaactggcc ttcctgaatg 428461 cctccgtcag tcgcctccca tgtcacggat actgatttgt catcatgttt ttgagtggaa 428521 accttccagc ccggaattgg ctcatattgc tggaattcaa catccttcgg cattttgagg 428581 acaaccttcg ttgtcggcag atttttctca gaaggaacct tcattgtata cgtttcccaa 428641 gagcctgcag cagactcagc cggttttaca gaaacatgcg cgctggcagg ggccgtaaag 428701 aataagaggg agccgacaat agccggacat agtgtcaatg cgattttttt caacaacgta 428761 aacactcctt aattggtctt tgtaaacatg atattgattt cgttaaagtc gccggtcagg 428821 ccgtggactt tgatcttcca gtttcctttt tcattaatcg acaggttttg atcttggaag 428881 acgccttttg ttttttcttt taatgtaaag gtgcttttgt tttcgctgcc tgacaggcct 428941 gttttataaa cggttaacgt gatttgctgg atgtttttca cgggatcacc gttatggtcg 429001 gtgacccgca gctcaaaaac attttttcca ggctggtttg ggctgatgct gagagaaacg 429061 ctttgtccgt tctctatcgc tttggtttgg tagaacggtt ccggcgctgg ctcaggcggg 429121 cttggcaggc ttgtaaacac ggccgctgtg atcaatacag cgatgccgat tgcccactcc 429181 gctttcaacg ttcggctgat tcctgtgcgg cgctgctttc tggtaagcag aaaatgaatt 429241 gcgcctaaga ccagcatgaa aacaaacagc ccgcttttca ctaaaagagc ttgtccgtac 429301 gctgtatgga acagtgaatc cattgaacga atgatgaaaa atccattgag caagcctgaa 429361 aacaaaatga cgccgactgc agtgagcgcc catggggaga accgtctgac cgtctcccac 429421 gcgagcgttt tgtcaggctg cctccattct tttgagagca gcaaaacgag tgccgctatt 429481 ccgccgaccc agatggaagc ggaagttaaa tgaaggaaat ccatcaaaat gccgaccgtt 429541 ttttcttcaa cgacagcagc atgcccggta aacgccttgg caagcaggag accgaaaaag 429601 aaaatgagcg gcgctgtcca atagccaaag gatgaaaagc ggtttttccg tatcgcaggg 429661 atgacagaca gtgcgagcag cacgaacagc gcagcctgta tgatccaaat ggagccgcct 429721 gctgtctcaa acagtgtttc tctgatgtag cccggctgga atgcgctgcc ccagccgccg 429781 cctgcgttcg cttttgtctg aatcggaagc tgaagcaaaa gcgccagccc caatgctgcg 429841 atcgagccgg tcaggatacg tctcgtccgt ttgacgagct gttctgattt ccctttatac 429901 cagaaaagat ggaagaaaac cgttccgata aacagagata aggctgtata cagaatcgcg 429961 cgatctgctg ctgttcccgg attcagcgct gaatcggctg ctttttggct gctgaatccg 430021 ccatccgctt tcccgatact gaacggaatg acgccggaaa caggatgtcc atccgcggat 430081 acggcattcc attccgctct gtacacatct ttaggcagat tcttcttcag cttcactgtc 430141 atgatgtgat gattatcttt tttgatttca gtcttgtccg tatccacacg gtcgccgttt 430201 gaattataga ctttaatgta atgaaaccct tcttcaaccg gttcattaaa ttcgatttcc 430261 acctgcgcag gggcgctttt taattcgctg ttttccccag gtgaagattt gacaatatag 430321 gcgtgagcaa agcttgtttt cggcaggaaa acaagaaaaa gcagaaggat gatccaccat 430381 ctgtttcgct tcatcactca gacaccacct tccgctgtat gtgttgtgtt atttcttggt 430441 gcaggtgcag cgtttctttc ggtcttgaag catgtcttcc agcgcttggt cgaaagtgca 430501 gacggctccg ccgaatcctt tttgaaatcg ttcggcatgg tcaagtgtcg caaacggaat 430561 ggcctgcggc tggcagcagt gcaggtttaa ttcagcattt acgacgaaat aagccgaacc 430621 ggcactgacg gttgtctgta acagaaaatc tctgcaaatc aagtgtgaaa cctcttccgt 430681 tttatccgcg taacgcaaaa acgcgcaatg tgcgcagcat agctgttcaa tgtcttggtt 430741 taccgtaatc agctgaaccg aatgagcttg attgacgggc ttcaagcaat agctgcacat 430801 atgatctgtt tgaggtgttc ggacggggag cgtgatgccg ccggccgttt taatgacctg 430861 atttgactga accagctgat tgacatctct atataccgtc atttccgaaa cgccgaacct 430921 tgcgctgatg tcagaaattc taagcgagcc ttcttctttc agccacttca gtatgtgttg 430981 ctgtctatta atcggaagca ttcatacacc ctcttcatta agatctattt aagcgtagag 431041 gattttagag acggagacaa gtaagtggat gataaaaaat gtgaaaatgt gttgaacagc 431101 aacaaaacga aacagaaggg actctggtat aatagacaga tggaatagaa agtgaggaat 431161 accctatgaa agaaacacca tgcccgaact gcggcaaacc tttgacaggc gatatggtca 431221 gatcatcaaa tgtgccttgt caatttcgct gcggccactg ccgggaacgg ctttatgaat 431281 ataaagtttc agctccgatt atgctggtat cattagcggc catcgtgctg cttatttatc 431341 ttttgatgct cctccgcaat gcggcaggct cagtgctgcc agctgtacag cacgtgccga 431401 tggctgtatt tgcgcttgtg tgcgcgtatc ccgtttttat tgtgagtgag cggatgattg 431461 caaagtacgt gattcaaaat ggcaacatca tttatagagg aaagagaaaa ggctcctgaa 431521 accaggagcc tttttatttt taaaaaattg tcacagtcat gtgccaaagt cctctttact 431581 ttcaattgta tagggactgt aagcgtttta acatagagtc aaagggaagc atcattctct 431641 gaacatattt ttgtatctta cagcgacaaa caaaacaggg agggtttata tatgcagcag 431701 caagaacagc agcaaggcgg catgaaagtg aaagtgcaac gctttgggag ttatttgagc 431761 ggaatgatca tgccgaatat cggcgcgttt atcgcgtggg gtatcattac cgcgctgttt 431821 attccggcag gatggtttcc gaatgaacag ctgaacacgc tggtcagccc gatgattacg 431881 tatttattgc cgcttttgat agcgtataca ggcggaaaaa tgatctacga ccaccgcggc 431941 ggagttgtcg gagcgacagc ggcaattggg gtgattgtag gatcggatat tccaatgttt 432001 ttaggcgcaa tgattatggg tccgcttggc ggatacctca ttaaacagac tgataaatta 432061 ttcaaggata aagtcaagca aggctttgaa atgctgatca acaactttac ggcagggatt 432121 gtcggcgcgg ctttaacgat tctcgcgttt tacgccatcg gcccggttgt cttgacgcta 432181 aataaattgc tggcggctgg tgtggaagtc attgtacacg ctaatttact gccggtagcc 432241 agtgtttttg tagaaccggc gaaagtgttg ttccttaaca acgccataaa ccatggaatc 432301 ttaagcccga tcggaatcga gcaagcatct caaacaggaa aatcaattct gtttttagta 432361 gaagcaaacc ctggaccggg gctcggcatt ttgctggcct acatgttctt tggcaaagga 432421 tcttcaaaat caacggctcc cggtgcggcg atcatccatt tcttcggagg gattcacgag 432481 atttacttcc cgtacattct gatgaaaccg gccctgattc tcgcagccat tgccggcgga 432541 gcaagcggac tcttaacatt tacgatcttt aatgccggac ttgtcgcggc agcgtcaccg 432601 ggaagcatta tcgcattgat ggcaatgacg ccaagaggag gctatttcgg cgtattggcg 432661 ggtgtattgg tcgctgcagc tgtatcgttc atcgtttcag cagtgatcct gaaatcctct 432721 aaagctagtg aagaagacct ggctgccgca acagaaaaaa tgcagtccat gaaggggaag 432781 aaaagccaag cagcagctgc tttagaggcg gaacaagcca aagcagaaga agcgtctgag 432841 ctgtctcctg aaagcgtgaa caaaattatc tttgcgtgtg atgcgggaat gggatcaagt 432901 gccatggggg catccatctt aagaaacaaa gtgaaaaaag cggagcttga catcagtgtg 432961 accaacacgg ccattaacaa tctgccaagc gatgcggata ttgtcatcac ccacaaagat 433021 ttaacagacc gcgcgaaagc aaagctgccg aacgcgacgc acatatcagt ggataacttc 433081 ttaaacagcc cgaaatacga cgagctgatt gaaaagctga aaaagtaatc ttatagaaag 433141 agagtgattg tcatgcaagt actcgcaaag gaaaacatta aactcaatca aacggtatca 433201 tcaaaagaag aggctatcaa attggcaggc cagacgctga ttgacaacgg ctacgtgaca 433261 gaggattaca ttagcaaaat gtttgaacgt gaagaaacgt cttctacgtt tatggggaat 433321 ttcattgcca ttccacacgg cacagaagaa gcgaaaagcg aggtgcttca ctcaggaatt 433381 tcaatcatac agattccaga gggcgttgag tacggagaag gcaacacggc aaaagtggta 433441 ttcggcattg cgggtaaaaa taatgagcat ttagacattt tgtctaacat cgccattatc 433501 tgttcagaag aagaaaacat tgaacgcctg atctccgcta aaagcgaaga agatttgatc 433561 gccattttca acgaggtgaa ctgacatgat cgccttacat ttcggtgcgg gaaatatcgg 433621 gagaggattt atcggcgcgc tgcttcacca ctccggctat gatgtggtgt ttgcggatgt 433681 gaacgaaacg atggtcagcc tcctcaatga aaaaaaagaa tacacagtgg aactggcgga 433741 agagggacgt tcatcggaga tcattggccc ggtgagcgct attaacagcg gcagtcagac 433801 cgaggagctg taccggctga tgaatgaggc ggcgctcatc acaacagctg tcggcccgaa 433861 tgtgctgaag ctgattgccc cgtctatcgc agaaggttta agacgaagaa atactgcaaa 433921 cacactgaat atcattgcct gcgaaaatat gattggcgga agcagcttct taaagaaaga 433981 aatatacagc catttaacgg aagcagagca gaaatccgtc agtgaaacgg taggttttcc 434041 gaattctgcc gttgaccgga tcgtcccgat tcagcatcat gaagacccgc tgaaagtatc 434101 ggttgaacca tttttcgaat gggtcattga tgaatcaggc tttaaaggga aaacaccagt 434161 cataaacggc gcactgtttg ttgatgattt aacgccgtac atcgaacgga agctgtttac 434221 ggtcaatacc ggacacgcgg tcacagcgta tgtcggctat cagcgcggac tcaaaacggt 434281 caaagaagca attgatcatc cggaaatccg ccgtgttgtt cattcggcgc tgcttgaaac 434341 tggtgactat ctcgtcaaat cgtatggctt taagcaaact gaacacgaac aatatatcaa 434401 aaaaatcatc ggtcgctttg aaaatccttt catttcggac gatgtgaccc gcgtagcgag 434461 gtcacctctc agaaaactgg gagaaaatga tagacttgta ggcccggcaa agaaaataaa 434521 agaaccgaat gcactggctg aaggaattgc cgcagcactg cgcttcgatt tcaccggtga 434581 ccctgaagcg gttgaactgc aagcgctgat cgaagaaaaa ggatacagcg gcgtacttca 434641 agaggtgtgc ggcattcagt cccatgaacc gttgcacgcc atcattttaa agaaacttaa 434701 tcaataaccg accacccgtg acacaatgtc acgggctttt tttactatct cgcaatctag 434761 tataatagaa agcgcttacg ataacagggg aaggagaatg acgatgaaac aatttgagat 434821 tgcggcaata ccgggagacg gagtaggaaa agaggttgta gcggctgctg agaaagtgct 434881 tcatacagcg gctgaggtac acggaggttt gtcattctca ttcacagctt ttccatggag 434941 ctgtgattat tacttggagc acggcaaaat gatgcccgaa gatggaatac atacgcttac 435001 tcaatttgaa gcagtttttt tgggagctgt cggaaatccg aagctggttc ccgatcatat 435061 atcgttatgg gggctgctgc tgaaaatccg gagggagctt gagctttcca ttaatatgag 435121 acccgccaaa caaatggcag gcattacgtc gccgcttctg catccaaatg attttgactt 435181 cgtggtgatt cgcgagaaca gtgaaggtga atacagtgaa gttggcgggc gcattcacag 435241 aggcgatgat gaaatcgcca tccagaatgc cgtgtttacg agaaaagcga cagaacgtgt 435301 catgcgcttt gccttcgaat tggcgaaaaa acggcgcagc catgtgacaa gcgccacaaa 435361 gtctaacggc atttatcacg cgatgccgtt ttgggatgaa gtctttcagc agacagccgc 435421 tgattatagc ggaatcgaaa catcatctca gcatattgat gcgctggccg ctttttttgt 435481 gacgcgtccg gaaacgtttg atgtcattgt ggcgagcaac ttgttcggtg atattttaac 435541 cgacatcagc tcaagcctga tgggaagcat cggcattgcg ccttctgcga acatcaatcc 435601 atccggcaaa tatccgtcca tgtttgaacc ggttcacggc tcagctcctg acattgccgg 435661 acagggcctt gccaatccga tcggccagat ttggacagcg aagctgatgc tcgaccactt 435721 cggagaggaa gaattggggg cgaaaattct ggatgtaatg gagcaagtga ctgccgacgg 435781 catcaaaaca cgcgacattg ggggacaaag cacaacggct gaggtcactg atgaaatctg 435841 ttcgcgctta agaaagctct gatgaatcag gccggtggca gatggctgcc ccggcctgtc 435901 catttcctta cgaaaatttc cacgaaagtc taaccaagca gatccaaatg ctgtataata 435961 atttggaatt cttaggaaag catcgggtga aggaagttga atgcaaaaac aatcacgtta 436021 aagaaaaaaa gaaaaatcaa aacgatcgtt gtactcagta tcattatgat cgcagctctc 436081 atttttacga tcagattggt gttttacaag ccttttctta ttgaaggatc atcaatggcc 436141 ccaacgctta aagactcaga aagaattctg gttgataaag cagtcaaatg gactggcggg 436201 tttcacagag gagacatcat agtcattcat gacaaaaaga gcggccgctc atttgtcaaa 436261 cgtttaatcg gtttgcctgg tgacagcatt aaaatgaaaa atgatcagct atacataaat 436321 gataaaaagg tggaagaacc atacttaaag gaatataaac aggaggtcaa agagtcgggt 436381 gtaaccttaa caggtgactt cgaagttgag gttccttccg gtaaatattt tgtgatggga 436441 gataaccgtc tcaattcact ggatagcaga aacggaatgg gcatgccttc tgaggacgat 436501 atcatcggta ctgaatctct cgtcttttat ccattcggtg agatgagaca ggcaaaataa 436561 aatgcaatgc aaaaagaaca tggaacatga cggcaccgat aataaagcgc cgtgcacgtt 436621 taaaaaaatg atgatgaaac ggtgcggagc cggctttccg ccccgttttt tatgatagaa 436681 agcgttttga agaaaagggc cctgttgaaa taaacagaat caggattggc gaagccgtga 436741 agcgcatcga attggtaaat ctcaagatgg gtatgctgtt tttcccgcag ttttttgata 436801 agaagcgcta cgtcaaacga cggctcataa ttagggaaaa acaataggac cgggcaggct 436861 ggcatgtgat gaagagagtc gcgtatccgg gaaccgtaat aacaaaccga tccgctcacc 436921 tcaggcatac tgctgcattt ccatgcgata gtagccccca cgctgaatcc aatcacaaag 436981 atgtgccgtc cggcgttttg cctgatcaca ttctggatga tggtttctcc cgttttcagc 437041 ctttcgtgtt ttgtaaattg ttcgtatgcc gttttttctt ctttcagtgt gtagacttca 437101 tcctcgccga gcaggttggg cgtcaacaca tcatatccag ccattttgat cagccggccc 437161 atctttttca tatggctgtt tacaccatat atttcgtgtg cgagaatgac aagcggtttt 437221 gggaacataa cggcctcctt ttgtgttttt tccattatat cctatcgttt cactttaggc 437281 tgagatataa tggtcaaaaa aaggagatat aaaatgaact cattatcttt gcctcaccgc 437341 tatccatttt tgtttattga tggcgtgacg gatagcgagc ccggcaaaca tgcggcagct 437401 tataagctga ttagtgagaa cgactggttt atcactgata cgcaaacaga aatgccgttt 437461 tcacttgtga ttgaagcgct tgcgcaaacc gcggctttta caggaattac agatgagaac 437521 agcttgggat tattgtcttc ggtgaagaaa gcggaaaagc tgggagaagc tgtgcctggt 437581 gaccggcttg atcttacgtt tgaagtcacg cgcaatcggc gcgggtttgt gttcggacat 437641 gccaaggcat cagttggaga gcagcctgtt gctgaagctg aaatcggcat ctatattgaa 437701 aaatgaaaaa aacccttcac aacattttgt gaggggttct attttgtgtc gtaatcccgt 437761 tcgctttgag agttatctct ttgctggcgt ttgtgttttt catcattcat attttccttc 437821 agctcttcat taggaatcgg atcggttaag tcgttgtgct cggggttttc atttggtttg 437881 ttttgctgtt ttttttctgt catgtttgat cacctcaccg tttgttttcc tcttattcat 437941 tctcctcaaa cataggaaat cgcttttttg tcccgctggg tataatgtat tagaatagag 438001 agaagcacaa caaaaagata aagagaggta catatatgtc tgttcaaaga gaagatgtag 438061 atatcaagct gatcgcaatt gatatggatg gtacactgct gaacgacgag cagctgatct 438121 cggatgaaaa ccgcaaagcc attcgtgaag cggaggataa aggtgtgtat gtggtgatca 438181 gcacgggccg gacgctgatg acgtgcaggg agctggcgga atcgctaaag ctgtcatcct 438241 ttctaatcac ggcaaacggc agtgaaattt gggattcgaa ttttaatttg gtggaacgga 438301 agctgcttca tacggaccat attcaaatga tgtgggattt gcggaataag cacaacacta 438361 atttctgggc ttctacggtg aataaagtat ggagaggcga gtttccggaa aacattacgg 438421 atcatgaatg gctcaaattc ggctttgaca tcgaggatga cgatatccga aacgaagtgc 438481 ttgaggagct gagaaaaaac aaagagctcg aaatcacaaa ttcaagtccg acaaacattg 438541 aagtcaacgc gcttggcatc aacaaagctg cagcccttgc caaggttacg gaaaaactcg 438601 gctttacaat ggagaatgtg atggcgatgg gcgacagcct taatgacatt gcgatgatca 438661 aagaagcggg tcttggcgtc gcaatgggca atgcgcaaga catcgtaaaa gaaacggctg 438721 attatatcac ggatacaaat attgaggatg gtgtcgctaa agcgattcgc cattgggtac 438781 tataaaaaaa gagagtccta agatggactc tcttttttag tttggcaggt tttattctgg 438841 gaccatggta ggttttctga caaaagtatt tcacaaactg atatgattca cttataatga 438901 aataaagttc aaaaattcgg aatagtcgtt ccgaatttcg ggacaataaa tgacataaag 438961 catatcgttt gctttggcag gagggattct gtgtttcaga ttgatttaaa ctgtgattta 439021 ggagaaagct tcggagccta caagataggc cttgaccaag atattttaga gtatgtgaca 439081 tcagcgaata tcgcatgcgg atttcatgca ggagatccta gtgttatgcg aaaaaccgtc 439141 gcgcttgcag cagaaagagg cgtgaaaatg ggtgcgcatc cgggcttgcc ggatttactc 439201 ggttttgggc gccgcaatat ggcgatttct cctgaggaag cgtatgatct tgtcgtttat 439261 caaattggcg cgctctctgg ctttctaaaa gcagagggac ttcacatgca gcacgtcaag 439321 ccgcatggcg ctttatacaa tatggcggca gtcgatcaaa aactgtcgga tgctatcgcg 439381 aaagctgtct ataaggttga tcccggcctg attcttttcg gtcttgctga gagcgagctt 439441 gtaaaagcgg gagaacggat cggacttcag accgcaaatg aagtgttcgc cgacagaaca 439501 taccaatcgg acggcacgct gacaccgcgc tcccagccgg acgcactcat tgaaagtgat 439561 gatgccgccg tcacccaggt catcaaaatg gtgaaagaag gggcggtcaa atctcagcaa 439621 ggacatgatg tgtcattaaa agcagataca gtctgcattc atggagatgg agcccatgcg 439681 ctgacatttg cgcaaaaaat cagaaaacag ctcaaagcgg ctggaattga agtgacagct 439741 atttcagaac agaggtcaac ataaaggagg aacaatagat ggagcagcag aaaaagacag 439801 caggaaaaaa agcgggcagc tggtcattgc tgatgggcgc cgccttttta atggcgacat 439861 cagcaatcgg accgggtttc ctcacccaaa ccgcaacatt cacaaacaca ctcgcagcaa 439921 gcttcggttt tgtcatctta atctctatta ttttagatat tttcgcccaa accaatgtgt 439981 ggcgcatcat cgcagtttct ggaaaacgag gtcaggaaat tgcgaatatg gtgcttcccg 440041 gactggggta tttcatcgcc attctcgtcg tgcttggcgg actagctttt aatattggga 440101 atatcggagg ggccgggctg ggacttcagg tgctgttcgg cattacacct gaaacaggcg 440161 ctttaatcag tgccgttatc gccattttga tttttgtcat caaggaagca ggaaaagcga 440221 tggaccgttt tacgcaaatc gcggggttcg tgatgattat tttaacggtc tacgttgcgg 440281 cgacgacagc tcctccggtc ggacaggcag tcgcaaatac attcgtcccg gaacacatca 440341 gcatatttgc cattgtcacc ctagtgggcg gaaccgtcgg cggttatatc acatttgccg 440401 gaggacaccg tttgcttgat gccggaatta aaggaaagga atccattccg caggtgacaa 440461 agagctcggt tgtcggcatt ttaattacat ctgtcatgcg tatcgctctt tttcttgcgg 440521 ttctaggcgt tgtatcgaaa ggcctgcaca tcgatgaaag caacccggcg gcttctgtct 440581 tcaagctggc tgctggaaat gtcggttata aaattttcgg attgatcatg tggtctgcgg 440641 cgattacgtc tgttattgga gcagcctata catctgtttc attttttaaa accttttctc 440701 caaaaattga aaagaattca cgcggtatta ttatcggatt tattgtggtt tctacgttag 440761 cttttgtcac aatcggccag cctgcgaaga tcctcgtcct tgtcggttca ctgaacggct 440821 taattctgcc gattgcgctc ggaacgctgc ttgttgccgc ctacaagaaa aacattgtcg 440881 gtgattataa gcatccgctt tggctgacaa gcacaggcgc gcttgtagtg attgtaatgg 440941 cagttatggg aatctacacg ttatgtacac aacttcctca attgtggagc tgatataagt 441001 ggagcaatta aacaaaatgg cgccaaagga tgtacgcgcc ctgatacgag aggggaaaat 441061 aaacgggccg accgcaggca tgtccggcgg ctacgcccaa gcgaatcttg tggttttgaa 441121 aaaggacctt gcgtttgatt ttctgctgtt ttgccagcga aatcaaaagc cctgccccgt 441181 gctggatgtg actgaagcag gttcgcctgt gccgtctctg gctgcgccgg atgctgatat 441241 cagaacggac tttccgaaat accgtattta caggcacggt atcctaacgg aagaagtatc 441301 tgatattacg ccatactggg aggacgattt tgtcggcttt ctgatcggat gcagtttctc 441361 ctttgaacag gcactgatca ataatgggat agctgtccgg catattgatg aggggacaaa 441421 cgtctcaatg tataaaacga atatcgattg tgttccggcg ggggcgtttc acggacagat 441481 ggttgtcagc atgaggccgg ttcctgaacg gctggctgta cgtgctgcac aagtgacctc 441541 gcgttttccg gctgtgcacg gagggccgat ccatattggc aatccgggag caatcgggat 441601 tcgcgatctc gggaaaccgg atttcggaga tgccgtttcc attcgtgacg gcgaggttcc 441661 tgttttttgg gcatgcggag tgaccccgca agccgtggct atgaatgtaa agcctgaaat 441721 ggtcatcaca catgcgccgg ggcatatgct catcacagat attcgagacg agtcgcttgc 441781 ggtgctgtag cctctcgtca tcctgatgaa cgagaattaa aagaggtgag aaagatgact 441841 gtacgatatc aaatcgaaca gctcggtgat tctgcaatga tgatccgatt cggagaagaa 441901 atcaatgaac aggtcaacgg cattgtccat gcagcggccg cttatataga agaacagcca 441961 tttccgggat tcattgaatg tatcccggct tttacaagtc taaccgtatt ttatgatatg 442021 tatgaagtgt acaagcattt gcctcaaggc ataagctcac cttttgagag tgtcaagcgc 442081 gatgtcgaag agcggctggc agaaatagcc gaagactatg aggtcaaccg ccgtattgta 442141 gaaattcccg tttgctatgg cggtgaattc ggtccggatt tagaagaggt ggcgaagatc 442201 aatcaactgt caccggagga agtaatcgac attcatacaa acggtgaata tgtggtgtat 442261 atgcttggct tcgcgcccgg ttttcctttt ctaggcggga tgtcaaaacg cattgcagct 442321 ccgagaaaat catcgccaag accgtcgatt cccgcaggtt cggtcggtat tgcgggattg 442381 cagacaggcg tttatccgat ttcaacgccg ggcggctggc agctgatcgg caaaacgccg 442441 ctggctcttt tccggccgca ggaaaacccg ccgacattgc tgcgggcggg agatattgtg 442501 aaattcgttc gcatctcaga aaaagactat cacgcctata aggaggagtc caattgagca 442561 tgaaagtatt aaagcccgga ctgctcacaa cggttcagga tataggcaga acgggttacc 442621 aaaaatacgg cgttctggcc agcggcgcta tggacacggt ttcactgcgc attgccaatc 442681 tgttgatagg aaacggcgaa aatgaagcag gtctcgaaat aacgatgatg gggcccggtc 442741 cgtcgtttca tttttcaaaa cagacactga ttgctgtgac aggggcggac ttcacgctgc 442801 gtattaatga cgaggaagcg cctttatgga agcctgtgct catcaaggaa aacagcacgg 442861 tcagctttgg cccctgcaaa ctcggcagcc gtgcttattt ggcggcagct ggcggcattg 442921 aggtgcctgc cgtcatggaa agtaaaagca catacgtcag aggaagcatt ggcggacttc 442981 atggcagagc gcttcaaaaa gaagatgaac tgaacattgg agagatgtca gctctttcgc 443041 aaaccatcct ttctcgctta agttcgcagc ttggaaaaca gggatttgca gcaccgaagt 443101 ggtcagtcag ccgcggcaga tttctgccat tgaagaagaa tcccgtcatt cgggtgctgg 443161 aaggaaagca atttgccttt ttcacagaag aatcaaaaac gcgtttttat gaagaagcat 443221 ttcgtgtcac gccgcagtcc gaccgtatgg gctacaggct caaaggagaa ccgctcgaac 443281 tgaaggcccc gcttgagatg gtgtcggaag cggtttcatt cggaacagtt caggtgccgc 443341 ctgacggcaa cccgattatc ctgcttgcag accggcagac gactggcggc tatccgagga 443401 tcgcgcacat catatccgct gatcttccga ttgtttccca aatcatgccg ggcgagcacg 443461 ttcagtttga gcctgtgtcc ctccaggagg cagaagcgct tgcggtagaa cgggaacagc 443521 atataaaaga actgaaaacg agaatgaaga tggaatggct gacatagcaa aggggatgaa 443581 tgatgcagaa taaaaataaa accgtagtca aatctatggc gctgcttaat ttgtttttgc 443641 ataaaccaag cctaacctta agtgaactgg tgtcgctgac gggaatgccg aagacctctg 443701 ttcaccggat ggtcagctcc ttggaggaaa tggggttcct cagtcgggat gcgtccggcg 443761 cttattcgct gggattggtg tttttggaat tcggacagct tgtcgctgac aggctggata 443821 tcagaaaaat agcgaaaccg gtgatggaag agctgtgccg ggaagtggat gaggccgtgc 443881 agttgatcat gagggacggc aatgaagcga tatacgttga gaaaatagaa gggacacaga 443941 ctgtgcggct gtatacggcg atcggcaggc gttcccccct atacgcggga gcgtgcgcca 444001 gaagcattct gtcctttctt ccccgtgaag aaatcgaagc atacatcaaa caaaccgagc 444061 tcatttcgat tggctccgga acgattaccg atcccgaaaa actgcttcag gagattgatg 444121 cctctgtgca aaatggctat actgtcagct attcagagct cgaaaactat acggcggcga 444181 tcggcgcccc gatctttaac catgagcgcc aggtggcagc cggcattagc attgcaggct 444241 ttgaagcgag atttacagaa gacaggctgc cctatttaac agaaaaggtg aaggacgccg 444301 ctttacagat ttcaagaaaa ataggatata cataagtagc caatcttttc tctgctgcgt 444361 acattaacgt atcgacgttc aagagtggag gaaagaacat ggtgcttcga tatacagctc 444421 tgggcgattc cttgacgaca gggagaggct ccgggctgtt ttcacccggc ttcgtccagc 444481 gttttgggga catgatggaa gctgacttga aaacaagaac ggcaataaac atatttgcca 444541 gatcaggtct gaatacagaa gagattttgg gactcctgtc atatccctat gtgcaaaaat 444601 gtattcgaga tgctgatatg ataacgatca cagggtgcgg aaacgatctc atcgattcgg 444661 tcttagccta ccaaacctct aaggatgaaa cgattttcag ccgtgtatcc gcccattgcc 444721 atgagaattt tgaaaagatg attgccaaag tcgccgagat taaaggagaa aatccttccc 444781 cgtacgccat tcgtgtgttc aacttataca atccgtttcc cgaaattgat atcgccggca 444841 aatggatcac ttcgtttaat tcacatttag aaacacttgc atcagcaccc catgtcaaaa 444901 tcgcggatgc ctatagcatc ttcaaaggca aagaacagga atatctgtcc tttgacggtg 444961 tccatccgaa cagcaaaggc tatcaagcga tggctgaagc cgttcacaag ctaggctata 445021 aagaattatc agtttcatag aaaacgcgcc tcatgacagg cgcgtttttt atgtgtgatc 445081 gaaatattaa aagaaactta aaattctctg tcttctgttc tacagacaaa caaagtgcgc 445141 tagaataatg gagggcgtag gcaaatatag ccataacgtt caatatttcg tatataagga 445201 aggatggtcc ttttgtttcg gatttttaaa atgtcttttg cggttatcat tattatactg 445261 gcgcttattg cttttaacta tacggaacac acctctgtaa tccaatcggt catgctcgtc 445321 tttcttggtg cggtcatgtt tatgcagggg cttgaagagc gcaaaaaaga aaatgacggc 445381 tcaggcgctt ttaatattta taccgccgtt tttgtatggt ctgtctccct tatcggtttt 445441 acacttcata ttatataaat ctattacaca tcctgaaaat gctcgaccgt cgggaacggg 445501 gtatagaacc gatgaagcaa ggctttccac tcttgatact ctgaagaacc gcgaaagcct 445561 tccgtatggt cctcaagtgt ttcccactcc acaagaagca gatatttatg cgtttcctcc 445621 atgcattttg ataacgagtg agtgatatag cccttcatgc cggaaataat cggcgcagct 445681 tgccggaatg catcctcaaa ctcttgttca aggccttctt taatgtgaag cattgctgcc 445741 tctctgacca tgctatccct tctttctgtc ttttcaaata gtctacagca aacgatagga 445801 gatttctgca aaatcggtga acttttcctt cattttcaaa aaaatcttgc acgcaccaat 445861 tcaattaaga gaaaataaca agtggaaggc aggggaaagt catgttaaaa aagtgtattc 445921 tactagtatt tctatgcgtc ggattgattg ggttaatcgg atgctccaaa acagattcac 445981 cagaggatcg catggaagca ttcgtgaaac agtggaacga tcagcaattc gatgacatgt 446041 atcaaagcct gactaaagat gtcaaaaaag aaatctccaa aaaagatttc gtcaacaggt 446101 ataaagccat ctatgagcag gccggcgtaa aaaatttgaa agtcactgcg ggagaagtag 446161 ataaggacga tcaagacaac aagacgatga aacatatccc gtataaagtc agcatgaaca 446221 caaatgccgg caaagtcagc ttcaagaata ctgctgtgct gaaattagaa aaaacagatg 446281 acgaggagtc atggaatata gattgggacc catcgtttat tttcaagcag ctggctgacg 446341 acaaaaccgt gcaaattatg agcattgaac cgaaacgagg ccaaatttac gataaaaatg 446401 gaaaaggctt agccgtcaat acagatgttc cggaaattgg aattgttccc ggagagcttg 446461 gcgataaaaa agagaaagtc ataaaagaac tcgccaaaaa acttgatttg actgaagacg 446521 acatcaagaa aaagctggat caaggctggg taaaagacga ttcgtttgtg ccgctcaaaa 446581 aggtcaagcc tgaccaggag aaattagttt ctgaagcgac gtcattacaa ggcgtaacaa 446641 gaacgaatgt cagctcccgc tactatccgt atggcgaaaa gacagcccat ttgacaggct 446701 atgtccgcgc cattacagcg gaagaactga agaaaaagaa agaaggaacg tacagcgata 446761 cgtctaacat cggtatcgcc ggacttgaaa atgtgtatga agacaagcta agaggcacaa 446821 ctggctggaa aatctacgtg ccgcaaaccg gggaagtcat cgctgaaaag aaagcaaagg 446881 acggcgagga tcttcacctc acaattgata tcaaaacgca aatgaagctg tatgatgaac 446941 tgaaggatga cagcggggcg gcagtcgcgc tgcagccgaa gacaggcgaa acactcgccc 447001 ttgtcagcgc gccttcctac gatccaaacg gatttatttt cggctggagc gataaggaat 447061 ggaaaaagct aaacaaagat aaaaacaatc cgttttcagc gaaattcaat aagacatacg 447121 cgccaggttc taccattaaa ccgattgcgg ctgctattgg aatcaaaaac ggcaccctta 447181 aagccgatga gaagaaaaca atcaaaggca aggagtggca aaaagattca agctggggcg 447241 gctattcagt gacacgtgtg tctgagagac ttcaacaagt cgatttggaa aacgccctta 447301 ttacgtcaga caatatttat tttgcccaga atgcgcttga tatgggagcg gacaccttta 447361 caaaaggctt gaagacattc ggtttttcag aggacgttcc gtacgaattc ccgatccaga 447421 aatcgtctat tgcaaatgac aagcttgatt cagacatttt gcttgcggat acaggctacg 447481 gacaagggca aatgcaaatg tctccgcttc acttggcaac tgcttacacg ccatttgttg 447541 acaatggaga ccttgtcaaa ccgacgctga tcaaaaaaga ttcacaaaca gctgatgttt 447601 ggcacaagca agtggtcacg aaggaaggag cggcagacat tacaaaaggt ctgaaaggcg 447661 ttgtggaaga tgagcgcgga tcagcgtatc agcctgtcgt gaaaggaatc acagtggctg 447721 gaaaaacagg aacagccgag ctgaaaacat caaaagatga taaagacggc acggaaaatg 447781 gctggtttgt cggctacgat tacgaaaaca aagacctgct tgtcgccatg atgatccaaa 447841 atgtgcagga ccgcggcggc agccactatg tcgttgagaa agcgaaaaag caatttcaat 447901 cgaattaaaa tgtcttttta aaaggagcga aaggaaaaag gggatctgag gccgaatgaa 447961 ctagtaaggg ggcaaaaccc ggtttataca aagaaaagag ggattttgca tgcagcgtat 448021 tcaattggcg gaggatcttc aattttcaag agtcatacac gggctttggc ggctgaatga 448081 atggaactat tcagatgctg aacttctaag cctcattgaa tggtgtatcg atcacggcat 448141 cacgaccttt gatcatgcgg atatttatgg aggctatacg tgcgaaaagc tgtttggaaa 448201 cgcccttgcc ctttcgcctg gattaagaga aaacatagag ttggtcacaa aatgcggtat 448261 cgttcttgaa tcgcctgaac ggcccgctca cagatcgcat cattataaca caagcaaatc 448321 gcatattttg gcatccgttg agcaatcgct tatgaacctt aggacggatt atatcgatat 448381 gcttttgatt cacagaccgg acccgctcat ggatccggag ggggtagcag aggcgtttca 448441 ggccttgaaa tgctctggca aggtcaggta ctttggcgtt tcaaatttta aagatcacca 448501 gtatcggatg ctggaatcat atttgcctga gaagctcgta accaaccaga ttgagctttc 448561 cgcatacgaa ttagaaaata tgctcgacgg cactttgaac ctgtgccagg aaaaacggat 448621 tccgccgatg gcttggtcgc ctctggcagg cggcaaagta ttcactgaaa acacggataa 448681 agaccgacgt gtccgtacgg cgcttgaatc cgtccaaggg gaaatcggcg ccgcttcatt 448741 ggacgaggtg atgtacgcat ggctgtatac gcatccggcc ggcatcatgc cgattgtcgg 448801 aagcggaaag cgcgagcgga tttccgccgc gataaatgcg ttgtcataca agcttgacca 448861 ggatcaatgg ttccgcattt ttacagccgt acagggttac gatattccat aaaaagcatc 448921 agtttaccag ctgatgcttt ttcaatattg tcacaccgct tagtgccaaa ttaccattta 448981 taagtgattg attctttctt gaaagcgttt tatattaaaa ggaaacctct ctatatcctc 449041 tactgcatct ccttgcgact tcatccgcac atcaagattg gctaggaggt cttttttatg 449101 tatatgactg ccagagaaca aaagctgtta aagcacttat tattacaaaa cagatatata 449161 accgtaactg agcttgctga gctgatgcaa gtcagcacga gaaccattca cagggaactc 449221 aaatcaatta aaccgctgat ggaaaccgtg gggcttacgt tagataaaca gcccggtaaa 449281 gggttgaaag cagtgggaag tcccgagggt aaacaaaagc tgcttactga tttatcatat 449341 gaacagcatg aatacagcgc cgacgaacgg aaactgctca ttctttgttc gttattagag 449401 tctcaggagc ccgtcaaact gtacacgctt gctcatgatc tccaggtgac gaatgccacg 449461 gtcagctatg acttagatga gctcgagaag tggatttctc cctttggact gacactgatc 449521 cgcaaaagag gttttggcat ccagctcata gggccggaga atgcgaaacg gaaaattgtc 449581 ggcaacttga ttgtgaaccg tctcgacatc caaatgtttt tggaagcggt tgaattaaac 449641 atcaaaggaa aaaccgattc ttcagagaaa atgttcgggg ttgtcagcaa aggtgagctg 449701 ttaaaaatgg agcgcatctt atttcagctc aaagaaaaaa tcgctttttc attgtccgac 449761 agctcctata tagcgctcgt cgtccatctg acgtatgcga tcgaacgaat taagcttggg 449821 gaaactatca ccatggagca aaatgagctt gaggaactga tgaatgcgaa ggaatacagc 449881 tccgctcttg aaatcgcggg cgagcttgaa cgtgccttcg gcgtgacgat tccagaggcg 449941 gaggtcggct atattacaat ccatcttcga agcgccaatc gaaaatacaa aacagaatac 450001 aaagcgcagg aaattgagct ggaaacagcc ctgcaaacaa agcggctcat tgcttttatt 450061 tcagacaaaa tcagaatgga tctgacgaaa aactactctt tatatgaagg cttgattgcc 450121 catttggagc cggccgtcag ccgcataaaa gaaaatattg agatatacaa tccgatgaag 450181 gaacagatca agcgcgatta ttttctgctt tatatggcga tcgaagaagg tgtcgaaaag 450241 tattttccgg gcatgtcctt ttctgatgat gaaatcgctt ttatcgttct tcactttggc 450301 tcggctcttg aaatcaaaaa agaagaagca aaagtgaaag cgcttgtcgt ctgctcaagc 450361 gggatcggct cctcgaaaat gcttgcctcc agactgaaaa aagagctgcc ggaaattgaa 450421 tcgtttgata tgtcatctct gatcgagcta aaggggaagg atgttcaagc ctatgatatg 450481 attgtgtcca ctgtaccgat tccttatgaa aacattgatt acatcatggt cagcccacta 450541 ttaaatgagg aagacgcaaa ccaggtcaag cagtatatca agcggaagat tccccttatt 450601 cttaacaaaa aaagaagctc gaaggaagag gcgcagcaag ctgatgtacc tgacatgctg 450661 gaggcggcgg aaagcatagg gcggtatatg gaagttatcc aagatgttct gcgccatttt 450721 acgctagctc aactcaaaac aaacccggac catagcatgc ttctgctaga gctttttcaa 450781 cagctgaaga aggatggcct gatccgtgat ccggaaaaag ccgcggtttg cctggctgag 450841 cgggagaaac aagggggatt gggaatcccc ggaacaaaca tggcgcttta tcatctcaaa 450901 aatgatgaaa tcgtcctgcc ttttttcaaa atgtttgatc tcagcacccc ctatgaagtg 450961 gatggcatgg acggaaatac cctcaggatg acacgcattc tcgtcatgat ggcgcctggc 451021 tcattatctg ctgaaggctc ggagatttta agcgcgatca gctcggcaat tatcgagagc 451081 ggagaaagca tggcggggtt tcaggaagaa ggaggacaag aattgtatca gcggttaaac 451141 cgcatatttt tcacatggat gaaagaaaaa aacatactgt aaacctgcat ggcacacgtc 451201 aaaaatttgg cgtgtgtttt tctgtggatg gggaacaaaa taagaaaatg tgggactatt 451261 ttatcattca gtattggaat aattccaaaa tgaaatagtt ttacaagtta tcttttttgg 451321 gttaaaatgg gtgaggtaag gaagaaaatc taacaaatta ttgaagattc aagagaatat 451381 aggagatgac gatatggaaa cattacagca tctgattctg catgacatgc cgaatagcga 451441 agaaatagag gctgtaaaaa gcggagacca tacactgaca tataaaggtt accgtaaacg 451501 gattaatcag ctggcgaatg ccatgcttca aaaaggaatt caaaagggcg accgtgttgc 451561 attgctttgc aaaaacggcc atcccgcctc aactgttatg ttcgccgcac ttgaaatagg 451621 tgctgttgtc gtacctgtca gctggcagct gaaaccatat gaaatgacag gcattttaaa 451681 agcaagtgaa ccaaaagcga tgttttacgg agcggagttt aaagagatac tggatgaagt 451741 tcttcctgaa ttgtcctcac tgtgtgtaac aatggaaaca ggaacagctt acgaaacatc 451801 tgctgaattt gaagcgctgt ttgcaggtcc tgatcatttg ccagagacgg aaatggtttc 451861 acctgatgat acagcacttc tgatgtttac atctggaaca acgggaaacc cgaaaagatg 451921 catgattaca catggcggca tatacagata cgttaaaaaa tccaacagct caatagcacg 451981 tatgaagggc cttcgttttc tcgcgtgcca tccgatttat catacgagtg cgctcatttg 452041 catcatgctt ggaacgtttg cagaaacaac atttgtgttt acaaaggatc aagatcctgt 452101 tcacatgctg aaggtcattg aagaagagaa gattcagacc gtgatggctc ttcctgtgtt 452161 ctacacgtat ttgcttgagg cgtgggaaaa gcaccaaact gacttatctt cgcttgttat 452221 tttaatgaca ggcggaacaa aagtgccgag cagcctaata agccgctatc ttgatattgg 452281 cattccgctt gcgcatggct atggaagtac tgaggcttgg ggcatcagca catggacgcc 452341 tgatatggga atggataaag cggcatctgc aggaaaacct gtggcaggtg ttaaagtcaa 452401 agtggaagat cctctgaccg gagaagaact tcctcaagga gaaatcggcg aaatcgttgt 452461 tcatactcca ttcttattta aaggctatga agacaatcct gaagcaacag cgaaagtgct 452521 gcaaaatgga tggtttagaa ccggagattc aggatatgta gatgaagatg gctttatttt 452581 catcacggga cgctacaagg atgtcattat ttacggaggc gataacgtct atcctgatca 452641 ggttgaagaa gttatccagc agatcccggg aatccttgaa acggctgtgg tcggtattcc 452701 tgacccgctt tacggtgaaa aaccgaaagc ttttatcgtg aaaaatggcg gccagcgcat 452761 cacggaagag gatgtcatcg cattttgtaa agaacgcctg tccgcttaca aaatacctga 452821 agttgaattt gttaacgaac tgccgaaaaa caaccttggc aaggtgaaaa aagacgtcct 452881 gcgcaatcag gctgtacatt cataaaagaa gaagcccgtc cactttatgt ggcgggcttc 452941 tttgcagttg cacagacgga aagctcaggc ttaatgttct taaattgtat atcaatgtct 453001 tcgaagccgg ctgctttaaa gtcagcaatc atctgtcttc caaatgattt ggttttctca 453061 ggactggcat ccgcttcccg cggctgcatc gtaatggctg ctttgccgcc tggctttaat 453121 gcccgataaa tctgttttat gccttttgtt tggtcattcc aaatggtgta gttgttaacg 453181 gaaatcactt tatcataaaa cgaggcgggg agaggaaatg tctcgatgct tccttgtatc 453241 aggcgtacgc cctttggttt cactctgcgg gcggccagct tcagcatggc ctctgataca 453301 tcaatcccat gaagatgaac atccttctcg cgtttcagca tctgctgcat gcagtatccc 453361 gggccaaacc cgacttctaa aatgctgtcc ccgcgcgtga tacccagctg attgattgtc 453421 cactgattca gtgtttgatt ttcagcagcc atgatgtacc cggcaatcat gccgatgacg 453481 ccctttggcc tgctgaatct tctagaaagc atgttaatca ttcagcaacc aacccccttt 453541 ttgagttaat ttcctctcag cgttccatgt gaaacatttt tctgataaag caatgcgaag 453601 gtgccaagcc atgtttatcc aaagagtgtg tgaggtacac aacaaataga catgaaaaca 453661 aaggaggaga atcatcatgg caaattatcc aaaagaactg ccggcacaaa ctcaaagtcg 453721 ccagccggga attgaaagcg aaatgaatcc aagtccggtg tatgagtacg aggattataa 453781 aggagcagac aaattaaaag gaaaagtagc tcttattaca ggcggcgaca gcgggatcgg 453841 acgcgcggtt tccgtcgctt acgcaaagga aggcgcagac atcgccattg tgtataagga 453901 tgagcatgaa gacgctgagg agacgaagaa acgtgttgaa caagaaggcg taaaatgcct 453961 gctgattgct ggtgacgtag gtgaagagga attctgcaat gaagcggttg aaaaaacggt 454021 caaggaacta ggcggccttg acatccttgt caacaatgca ggtgaacagc acccgaagga 454081 aagcatcaaa gatattacga gcgaacagct tcaccgcaca ttcaaaacaa atttttattc 454141 tcaattttat ttgactaaaa aagcaattga ttacctgaaa ccgggcagcg ccatcatcaa 454201 tacgacatcc atcaacccgt acgtagggaa cccgacactg attgattata cagcgacaaa 454261 aggggcgatc aatgccttta caagaacaat ggcgcaggcg cttgtcaaag acggcatccg 454321 tgtaaatgca gtcgcgccgg gtccaatttg gacgccacta atcccagcta cgttccctga 454381 agaaacagtt gctcaatttg ggcaagatac gccgatgggc cgtcctggac agcctgttga 454441 gcacgtcggc tgttatgtgc ttctggcatc agatgagtcc tcttacatga caggtcagac 454501 cctgcatgtc aacggcggaa actttgtgac gacataagag ggagtgagac atatgggcat 454561 cacgaaagaa gaagtgaaca gctactatca aaaagcaggg attgtattaa cggacgagga 454621 agtagaccaa atccagctga tggattacgg cttaggaaaa gaaagaaaag tcgggctcca 454681 gctcttcgtc tacgtcaata cagaccgtta ttgttcaaag gaattggtgc tgtttccggg 454741 acagacttgc ccggaacacc gccatccacc ggtcgacggc caggaaggca agcaggagac 454801 cttccgctgc cgctacggaa aagtgtatct ttacgtagaa ggagaaaaaa cgccgcttcc 454861 aaaagttctc cctcctcagg aagacagaga acactatacg gtctggcacg aaattgagct 454921 agaaccgggc gggcaataca cgattccacc aaacacaaag cattggttcc aggccgggga 454981 agaaggtgcc gtcgtgacgg aaatgtcatc gacgagcacg gataaacatg atatctttac 455041 cgatccaaga atataaggat gggcttaaca gcccatcctt tttgtattga aaaaaacaga 455101 atcatcgcta taatgggtaa aaaaggaaag agggcgaggc aatgttcact tgcaaggtaa 455161 atgagcacat caccatccga ttattggagc cgaaggatgc ggagcggctg gccgaactca 455221 ttatccaaaa tcagcagcgg cttggcaagt ggctgttttt tgcggaaaat ccaagcagcg 455281 ctgacacgta ccgagaaaca atcattccag attggcggcg ccagtatgcc gacctgaacg 455341 gcattgaggc gggtctcctt tatgacggca gcctatgcgg catgatcagc ctgcataacc 455401 ttgatcaagt gaatcgtaag gcggaaatcg gatattggat tgccaaagaa tttgaaggga 455461 aaggcattat tacagctgcc tgccgaaaac tcattacgta tgcttttgaa gagcttgagc 455521 tgaatcgtgt ggcgatctgt gcggctgtcg gaaacgaaaa aagcagagcg gttccggagc 455581 ggatcgggtt tctagaggaa ggaaaggcac gggatggctt atacgtaaac ggcatgcatc 455641 acgacctcgt ctactacagt ctgttaaagc gtgaatggga aggcgaaaaa taaagagcac 455701 actttcttgt ttaaatcttc cccggatgtg gaaaagtaac agcggagacg ttaaaaagga 455761 gtgattcgag atgaatcagc aagacattaa acaaaaagtg cttgatgttc tagatcacca 455821 taaagtaggt tcgctcgcaa cagttcaaaa gggcaaaccg cattcccgct acatgacttt 455881 tttccatgac gggctgacga tttacacacc gacaagcaag gaaactcata aagcggaaga 455941 aattgagaac aaccccaatg tccacatttt attaggctat gattgtgaag gttttggcga 456001 cgcatatgtc gaagttgccg gaaaagcaaa gatcaacaat tcggcagaac tcaaggacaa 456061 aatatggagt tccaaattag agcgctggtt tgacggcaag gatgatccga atctggtgat 456121 tcttgaaatt gaaccggagg atatcagatt aatgaatgcc ggggagaaaa caccggtctc 456181 actcgaacta taaaaaattt gtgttttcag gggcgatatg ttattatgaa tagctagtaa 456241 gaaaaataag caaataaaaa agaaagtaaa cttctttttt ctgttttgag agagaagctt 456301 accgcttccc aagcagcata accagctgcc cttattcttt tccttcataa caaatcgccc 456361 ctaacgatga gatggaaaaa agactttttt gttttacaat tcacaccggc gcggcttcgg 456421 agccgcagtg acgattgaga ggtagggctt tcgttgtctt gtgttcaaga aatttccatg 456481 gtgtttactt tccagaatga ttcttcggaa caatgcttta tgaatctaac ccgcctgact 456541 tggcggatga tataatcttt atttgcgtat agaaaagaat aagacaaacc gcccggcgta 456601 cgccggacgg tttttttatt gcaaaaaaca catcgtactg aaacctcctt gtcttctttc 456661 cagtcttatc tctaggatga aattggagga agaataacgt gcatgtcatt acaacacaag 456721 tactttttat tttttgtttt ttattgctga ttcactcgat agaaacctta gcctatgcga 456781 caaggctttc cggagctcgc gttggattta ttgcgtccgc gctttctctg tttaatgtca 456841 tggtcatcgt atccagaatg tcgaatatgg tgcagcagcc ctttactggg catttaattg 456901 atgatgctgg aaaaaacgca ctggcgattg taggggagca gttccgcttt ttaattttcg 456961 gatcgacagt cggcaccatt ttgggcatta tcctgctccc gtcttttgtc gctctttttt 457021 cacgggcgat tattcacttg gcgggcggcg gcggctccgt ttttcaagta ttccgaaagg 457081 gattctcgaa acaaggattc aaaaatgccc tttcctattt gcgtctgccg tccatttcat 457141 atgtaaaagg atttcatatg cgcttgattc cgaagcgttt gtttgtcatc aacatgctga 457201 tcacatcgat ttatacgatt ggtgtgcttt cggctttata cgcaggcctt ttggcgccgg 457261 agcgcagcac gacagccgtc atggcttcgg gtttgatcaa cggaattgca acgatgctgc 457321 tggctatttt tgttgatcct aaggtatccg ttcttgctga tgatgtggca aaaggaaaac 457381 gaagctatat ctatttaaaa tggacctctg tcacaatggt cacatcaagg gtggcgggca 457441 cactcctcgc ccagctcatg tttattcccg gggcctacta tatcgcgtgg ctgacaaagt 457501 ggttttaata agaaaggctg gatcataaag atccagcctt tttgcgcttc cttatttata 457561 gttccttaat ccgcggtcgt acaaaaaatt tccgaatggg acgaaagcgg cgatgaagcc 457621 ggcagctgac catttcagcg gccatttgac agagaaggtt gcataagcca agacaagcaa 457681 atacaaaatg aacaacccgc cgtgaaccga accgacaatt gtcaccgcaa gcggaaggcc 457741 tgcccaatat ttaagcggca tagcgatgaa caacaggatt aagagtgaca ttccttcaat 457801 aaaacccatc gtgcgaagtc ttccgatcgg cgtgtgcagc ataaatcgcc ctccttgtgg 457861 acacgttttc attttatact ataaacaatc cgggggggca tatgacagct ttcaaaaaat 457921 gttcggaaaa cattcatttt tacatgcctt ttctagggaa ctgtacttgt catttacaaa 457981 aatacccgag ataatgtgta caaaatcaaa aaagaaggat gttgaaatga aacttgacca 458041 gattgatctg aatatcattg aggagctgaa gaaggacagc cgtttgtcga tgagggaatt 458101 aggcagaaaa attaagctgt cgcctccatc tgtaacagaa cgggtaagac agcttgaatc 458161 gtttggcatc atcaagcaat acacgctgga ggtcgaccag aaaaaactgg ggcttcccgt 458221 ttcctgcatt gtggaagcaa ccgttaaaaa cgcggattat gagcggttca aaagctatat 458281 tcaaacattg ccgaatattg aattttgcta ccggattgcg ggtgcagcct gctatatgct 458341 gaaaatcaat gccgaaagcc tcgaagcggt agaagatttc attaacaaaa catcgcccta 458401 cgcgcaaacc gtcactcacg tcattttctc agaaattgac acgaaaaacg ggcgcggtta 458461 gagagtgccg cgcgaagtct gttataataa caggatgagc gtgaaagaaa gagaagtgat 458521 caagcatgtc aaaaacagtt gtattagctg aaaaaccttc agtcggccgg gatttagccc 458581 gggtactgaa gtgccataaa aaaggaaacg gttatctcga aggcgatcaa tatattgtga 458641 cttgggcttt aggccatttg gtgacgcttg ctgatccgga aggctacgga aaagaatttc 458701 aatcatggcg cctagaggat ctgccgatta tcccagaacc cttgaagctt gtggtgataa 458761 aaaaaaccgg aaagcagttc aatgcagtca aatcccagct tacccgtaaa gacgtcaatc 458821 agattgtcat cgcgactgac gcaggccggg aaggtgagct tgttgcgcgc tggatcattg 458881 agaaagcgaa tgtccgaaaa ccaatcaagc ggctgtggat ttcatctgtg acggataaag 458941 cgatcaagga aggttttcaa aagctgcgca gcggcaaaga atatgaaaac ctgtaccatt 459001 ctgccgtcgc cagagcggaa gcggattgga ttgtggggat caacgccacc cgtgcactta 459061 ccacaaaatt caatgcccag ctctcatgcg ggcgtgtgca gactccgacg cttgccatga 459121 ttgcaaagcg cgaggcagac attcaggcgt ttacgcccgt tccgtattac ggcatacgtg 459181 ctgcagtcga cggcatgacg ctgacgtggc aggataagaa atcaaagcag acgagaacgt 459241 tcaatcaaga tgtaacaagc cgtttgctaa aaaatctcca aggaaagcaa gcggtcgtag 459301 ctgagctgaa aaaaacagcg aaaaaaagct ttgcgcctgc gctttatgat ttaacggagc 459361 tccagcgtga cgcccacaag cgcttcggtt tttctgccaa agaaacgctt tctgtcctgc 459421 agaagctata tgagcagcat aagctcgtca catatccgcg gacggactct agatttttat 459481 ccagtgacat cgtcccgacg ttaaaagacc gtctggaagg catggaagta aaaccgtatg 459541 cccaatatgt cagccaaatt aaaaaacgcg gcattaaatc tcataaagga tatgtcaatg 459601 acgcgaaggt gtcagaccac cacgcgatta tcccgaccga agagccgctc gttctcagca 459661 gtctgagtga taaagaacga aagctgtatg acctgattgc gaaacgtttc ctggctgtat 459721 taatgcctgc attcgaatat gaggaaacaa aggtcatcgc agaaatcggc ggagaaacct 459781 ttacggcgaa aggcaaaacc gtgcagtcgc aagggtggaa agccgtttat gatatggcgg 459841 aagaggatga tgagcaggag gatgacagag atcagacact tcctgcgctt caaaaaggcg 459901 acacacttgc cgtccgcacg ttaacggaaa caagcggcca aacgaagccg cctgcccgct 459961 ttaatgaagg gaccttgctg tcagcgatgg aaaacccaag cgcgtttatg cagggagaag 460021 aaaaaggcct cgtcaaaacg cttggagaaa caggcggcct cggcacggtg gcaacgcgtg 460081 ccgacattat tgaaaaactg ttcaacagct ttttaatcga gaaaaaaggc caagatattt 460141 ttatcacatc taaaggaaaa cagctcctgc agcttgttcc ggaggatctg aaatcaccgg 460201 ccttaacagc agaatgggag caaaagctgt ctgcgatcgc ggccggcaaa ttgaaatcgg 460261 ctgtttttat taaagatatg aaggcttacg ctcaccaaac ggtaaaagaa atcaaaaaca 460321 gcagccaaac cttccgacat gacaacatta cgggaacggc atgtccggaa tgcggcaaaa 460381 tgatgctgaa agtaaacggc aaacgcggga cgatgctcgt gtgccaagat cgtgaatgcg 460441 gaagcagaaa aacgattgcc cgaaaaacaa acgcacgctg cccaaattgc cataaaagaa 460501 tggagcttcg cggccaaggc gagggccaaa cctttgcgtg tgtgtgcggt caccgtgaaa 460561 agctctctgt atttgaaaaa cgaaaaaaca aagacaaagc gcgtgctacc aaacgggacg 460621 tatcctctta tatgaaaaaa caaaataaag atgagccgat taacaacgcg ctggcagaac 460681 agctgaaaaa actcggtttg gataaataat aaaaaaacct gtgcctatcg cacaggtttt 460741 ttattggact taggtcctgt tttcttaatg ttcaaaaagg gaaaaaaaag ctagcaatct 460801 gcattttttt tcttttatag taaatgtact ttgtaacatg gcagtcatat tttcgtctat 460861 aactatttgt gagcgtctga tttgcttcag gcgacaaagg gggatttgcc tgtgaggcat 460921 gtactaattg ctgtcatctt attcttctta tctatcggac tttccgcagg gtgtgctgaa 460981 gctggaaaca agacccaaaa tcagtcggcg acagaagtga atgccagccc gctccagccg 461041 gcggaatatt tcatctatca caatttaatg aatgacaaag ggctgatcaa aaccgatttt 461101 tcagaccagc cttcttactt gtcggaatct ctcggactgt ggatggagtt tctgctcagc 461161 aaaaatgacg caccacattt ccaggatcaa tatcagcatc tgactgattc atttctgatg 461221 agcaatcact tggtgacgtg gaagattcaa aatggccaag cgagcgggac gaatgcgctg 461281 atagatgata tgagaattat gctgtctctt gaccaagccg ccgcaaaatg gggccgcagc 461341 gactacgcgc aaacggctag ggatatcggc acgtctttga agacatacaa tatgaacaac 461401 gggtttttta cagactttta cgactcacag gccgcttcaa aggatgtgac gctttcatac 461461 gtcatgcctg atgccttagc tgtcttaaag aagaatggaa tcatagacga agaaacagaa 461521 cagcggaatg ccaatgttct ctattcagct cctttaaaaa atggctttct gccgaagaca 461581 tacagctcgg agacgaagga atacacatat gatagtgaaa tcaacctgat tgatcagctt 461641 tacgctgctt ggcatttgcc ggaaggggat gaaaaagcat ctgttttagc ggactggatc 461701 aagcaggaat ttcagaaaaa cggaaagctg tacgggcggt attcggcata tacgaaggag 461761 cctgccgtcc aatatgagtc tccatccgta tatgccttag ccgtattgtt tttgacaaaa 461821 cagcatgaaa acagttctgt catcaaagcc atatatgata gaatgaatga ctttgaaatt 461881 catgatccgg tgaaatcgta ttatggaggc tatatgagcg gcactcagac gcattcattt 461941 gacaatctgc tgccgctgtt agccgaaagg aagcttttta atgaaaatat cattcagtga 462001 atcacaaaaa ttatttgctt atttttcagg gctcatcgcg gccctgtctt tgtttattta 462061 ttatgtgtca gcccagcaat cagaaggtgc tctgatcctt tgcatcacat ttggcgtcat 462121 cgccgcaggc atctggttcg gcccgattta cgcgctggca gtgaccttaa tcgtactctt 462181 tgttctcggc accttaatga tgtttttcca gactggacag acatcgctct ttccggctga 462241 ggaagggctg cgaatgcttg tcgtgtgggg aatcgcgctt ttgctgtttt cttttatttc 462301 tggaagaatc cacgatatta cagcagagct tcggcgctca atgacacggc ttcaatccga 462361 aattaaaagc tatgttgctg ttgacagagt gactggtttt gataacaagc aaaggatgaa 462421 gctggaactt tcagaagaaa tcaagcgggc ggagcgctac ggcaattctt ttgtgttttt 462481 gctgctccat atgcattatt tcaaagagtt taagtctttg tacggtgaaa aagaaacgga 462541 ccgcctcttc caatatgtcg gtcagcaaat caggacaagc gttcgggaaa cggataagaa 462601 attccgtccc tctgacgagc gtatcgggat cgtgctgacg cacacgcctg ctgaacatat 462661 gccggccgtt ctgactaagc tgaagaaaca attggataca tatcagctgg aaaatggaaa 462721 gtatgtgtcg cttacgttcc acgtttgcta tttgccctac cgcaacgata tccaaacagc 462781 tgatcaattt ttagaagaac tggaaaacga gatgatgatg aatgaactat aaaggaatca 462841 cattgctatg cgtcatgatg cttctatttt cagctattgc gtcttttccc gtttctgcgc 462901 aagcgaaaga tcaggatgcc ggcattctca tcatctactc aaccttggac ggcaaagagt 462961 cgtcacaagt caaaatgctc gatttgcttg cgggccactt tacatcccat gtgacagtca 463021 aaaaagattc agacgttgaa gcgtcggatt tcaaagggaa agaccatgtg atttattacg 463081 gccaaacgaa aagaaagctc agccaaaaat tgctgtctct tatcagcggc gtgaaaaaac 463141 cggttgtcgc cattggctat aacgcaggcc aaatcagcca attttctggg ctttcattag 463201 cccgcaaaga aaatgtgttt caggttcaca gcaggtcaga aaaggccgat gtgtctctgg 463261 aaagcgggct taacgtgctg agtgtatcag gcctgaaagg aacggcgctt tacaccttca 463321 aagcggatga aggcacaacg cattctttta tatggaaaac aaaaaaaggg aatgtgtaca 463381 ttggattaac aaatttgtta aatgacaatt tgatcgtggc gaaacagctc agagaagctt 463441 tcggagagaa ggcggggacg acgttattgt atttgcgtct cgaggatatc agcccgatgt 463501 ctgatgaaaa actgctgctt caagccggta catacctgca taagcggcat attcctttta 463561 tcctggcggt cattccggtt tacttgaatc cggaaacagg cgacaaagtg tatttgtcta 463621 atcaaccgaa gatggtcaag gtgctgaaga agctgcaaag catgggcggc agtatcatag 463681 ttcacggcta tactcacgct tatcgctaca gtgaaacagg agagggattt gaattttggg 463741 atgcaaaggc ggatcagccg attacatccg gaaatgccga agaccccccg tccattttgg 463801 agaaagaaca ggacttcccg aacgaacaag cctatcacag ctatcttgaa ccatttcggg 463861 aaaaggaaga aacgtataca aaacaaaaac tgacgcgtgc cattgaggat ttgacatcat 463921 cgggtcttta cccgctggcg tttgaagcgc cgcattacac gatgtccgaa tatggctatc 463981 aaatcgcctc gcagtatttt acaagcattt tcggccaggt ccagctcagc agcacaacat 464041 ggaaaacatc cggtgcacct ccgtttgtga ctgctccttc gatgctgcac ggaatgacgc 464101 tttatccgga aacgatcggc tttgtcgaca catcgaagca aaacccgctc ggtgagatgg 464161 aggagcatat ctcccagatg attgattttg aaggcggagt agccggagga ttttatcacc 464221 cgtaccttgg gatgaaatat ctgcctgagc tggttgatca gatggaacgc attccagaca 464281 gtgaatggct tgatttaaag aaaacgaaac aaaccgtcaa aacagacaaa gtggaaattc 464341 atacaagcgg tgacggaacg attcaggtga aaaacggcgt aagccccatt tacgagtttt 464401 tcgatcatca ccggcaaacc cctctggaaa aggcgttatg gattctctcc gctgttgtgc 464461 tcttatttgt catcatgttt gtcagttata cgttttactt gagagccaca ttgaaaaaac 464521 gaatttttaa ggagagaaga agccttgggt aatacgctgt tctttatctc gctaagttta 464581 atatgggtta tgcttctcta ccacatgttc ctcatgcagg gcgggtttcg ccactatatg 464641 accttcgaac ggaatatccc gaagtggaga gaaaatatga aggaactgcc gaaggtcagc 464701 gtcctcatcc cggcgcataa cgaagaggtt gtgattcggc agacgctgaa ggccatggtc 464761 aacctttatt atccgaagga ccggctggag attatcgtcg ttaatgataa ttcatcagac 464821 cggacgggtg atatcgtcaa tgaattttcc gagaaatacg atttcatcaa aatggtgatt 464881 acgaagccgc caaatgcagg aaaaggaaaa tcctctgcac ttaactcggg ttttgccgaa 464941 tcgaacggcg atgtgatctg tgtgtatgac gccgacaaca cgcctgagaa aatggccgtg 465001 tattacctcg tgctcggcct gatgaatgac gaaaaggcag gcgccgtggt agggaaattc 465061 cgcgtcatca atgcggcaaa gacgctgctg acgaggttta ttaatatcga aacgatctgt 465121 tttcagtgga tggcccaggg aggcagatgg aagtggttca aaatcgccac gatcccaggc 465181 accaacttcg cgatccgcag aagcattatc gaaaagctcg gaggctggga tgacaaagcg 465241 ctcgctgagg atactgagct gaccatccgg gtatataatc tcggctatca catccgcttt 465301 ttccctgccg ccatcacgtg ggagcaggaa ccggaaacat ggaaggtatg gtggcgccag 465361 cgcacccgat gggcgcgcgg caatcaatat gtcgtgctca aatttttggc gcagtttttt 465421 aagctgaaac gaaaacggat tatctttgat ttgttttatt ttttctttac gtacttcctg 465481 tttttctttg gcgtgatcat gtcaaatgcg atttttgtag tgaatttgtt ttatgatttg 465541 catttgtctg ttggattttt ggcaatgatt ctctggattt tggcgttttt cttatttatg 465601 acagaggtca tgattacgtt gagcattgaa aaaacagaaa tgaacaagca aaactttttt 465661 atcgtatttc tcatgtactt cacatactcg caggcatgga ttgtgcttgt tatctactct 465721 ttattcgtag aaatcaagca ccgtttattc aagcaagagg tcaaatggta caagacagaa 465781 cgatacaatc aacataaaag cgggtgacct ttttgaaaca aataatgatt tttctcacaa 465841 gcttcatgct gctggcgatg actggacaaa cggctcttgc caaagacgta caggtcagcg 465901 gttcgctcct tgggaaaagc agccaagaac aagccaaaca gcaggtgctg acaagcgagc 465961 tgattacact gtatggatca aaagacagcg cagagctgac gtatcagatc ccggcaggcg 466021 cctcttcggg caatcagcaa ttggtaatcg aatacgaggc atcaaatctt ttaatttctc 466081 catcatcgtt aacggttgtc attgatgatg aaccggtcaa gacgttaaag cttgatggtg 466141 attccaaacg gaaaacagtg aagctgaatc tgaataaaag ccagtctgcg caaggctatc 466201 acaacgtatc gctgaaattc tacggcgtaa tgaaagaggg cgtgtgcgtc agacaggata 466261 catcaggcaa ctggatcaaa atttatccgg acagccggct gacacttgct gacagcagtg 466321 aagcgaaggg aacgtcgctg gaccattatc cgtatccttt cgcccaatct ggaaatacag 466381 cggaagaaac agctatcgtc attccggata acccaagttc agcagaaata gaagctgctg 466441 ttaaaacaga aggctatttg aaaacggtgg acagcagtgt cagtattgcg tatgtcacgg 466501 aatctgaact gaaaaaaatc gataagccga cgattgttat cggcgtggac aagcattgga 466561 acggcaaagt gaaaaaactg ttgaaacaag ccgggctaca ggcaaaagga gaaaaccttc 466621 tgcttgcgga gcgggtgctg aaagcagagg gcaaacagca gccggttctg tttgcgcaag 466681 cggcgtccga ggacgcgctc acaaaaaaaa tcagcgtgat gacagatcag acatatacag 466741 gccagctcag cggcgataca ctttcaatca gcaagcttca gcagactgaa aaaaaagaaa 466801 gcgataagct gacccttgag aattttggag cgggtgatat cacaattgga gccgacaaaa 466861 catcttcagc acattatttt tatccggctt cggctgtttt agatgaaaac caatcggcga 466921 agctgtcgct taaactgaaa aagtctgaaa cgattcaagc ctcaacggct gaaaacgagt 466981 cagcctctca ggctgcagaa ctgaaagtga tgatcaacgg ccagccgcac tcggtccggc 467041 ttgatgaatt aggaaaagaa gataaaaacg gattctatca tgtcacagtg aaagtggacc 467101 ctaagctgct gcaaaaaaac cgctacattg atattcagtt cgtcacgacc ggtttaaagg 467161 aaaacaaccc ttgtaacacc actgatgaag aaaagtgggt ttttatcgat aaaaacagta 467221 cattatcata cgccatcaaa ggcatgtccc cgtcagcgga ttttcaagag tggccgctgc 467281 cttacgccgg aaaccaggat caaacaacgt taatcgtgct tcctgacacc gtaagccaat 467341 cgaagctaga ggagctttct ctcgtaacag aatcctttgg caacgaagca cagcattcat 467401 atacggtaaa gaaatcatct gacgttacag caaatgatgc gaaaggacga aacctcattt 467461 tcataggagg gatcaatcaa ttttctcttc tgaaggagaa atcatcagat ctgcttgtgc 467521 cgcaggaaaa gaacggctcg tttgatgtat ctagtttcga gatgctgaat gagacgacaa 467581 aacaagtggt atttacccaa gcatcggttt gggattcacg ctatacaatg gctgtctttg 467641 caccgtcaaa aggagatggc acggctgtca caaaagagat catcagttat ctgaacagca 467701 acgatgagtc ggcaaccgtc cttaatgaaa caaacagcca gcaggtgttt acaaaccacc 467761 agcagctcaa atcggaaaca aacagttccg atgcagaaca accaacacag gatcatagcc 467821 agaaatggat gtatattggt gtgctggcac tcattatggt ggttgcggca gtgttcattt 467881 ggattgccgt aagacgcaaa aaaagaaaga cagatacaga ataaaacaga ggcgatttta 467941 gcctctgttt ttttattttt ggtaagtaaa ttccatttgt ggaacctgtc attttatttt 468001 tttctctcag ccaataagcc tctttacaac gtgcgggaac gggagtatga tctcttttag 468061 aaaacaaatc gcttaatctg aaatcagagc gggggaccca atagaacggc tttttgccgt 468121 tggggtgaat cctttttagg tagggctaac tctcatatgc ccgaatccgt cagctaacct 468181 cgtaagcgtt cgtgagagga gatgaatgaa acctgtgttc gatgttatgg cacaggggca 468241 tccgtttgcc tctgtgtttt ttgttgttca tttttgaatg caaatcgcat acagagacat 468301 catagcagaa aggactatca tcaacatgtg agagcaagac actgatggat gttttattgt 468361 tttaattgaa aaatgagaaa ttaaaagggg aagacatcga tgtatcattc aatcaaacgt 468421 tttttgattg ggaaaccact aaaatcccaa gcagctggag agcaaaaact gacgaaatta 468481 aaagccttgg ctatgctttc ctcagatgcg ctgtcatctg tcgcatatgg gacagaacaa 468541 attctaatca ttttggcaac aatcagtgca gccgcatttt ggtactccat tccgattgcg 468601 gttggcgttc tcatcttgct gctcgcactg attctttcat acaggcaaat tatttacgct 468661 tatccgcagg gcggcggggc gtatatcgtt tctaaagaaa atctcggtga aaaaccggga 468721 ttgattgcgg gcggttcatt gcttgttgat tatattttaa cagtagcggt aagtatttcc 468781 gcaggcacgg atgccatcac gtcagccttt cctgcattgc atgattatca tgtgccgatc 468841 gctatttttc tcgtgttagt gattatgatt ttgaacctgc gcgggctttc ggaatcagca 468901 tccatacttg cctacccggt ttatctgttt gtggtggcgc ttttggttct cattgcagtc 468961 gggttgttta aacttatgac aggacaaata gaccagccag cccatcatac atcgctcggc 469021 acacctgtag ccggcattac gctatttttg ctgcttaagg ctttttcctc cggatgctca 469081 gcgttgaccg gggttgaggc catttctaat gcgattcctg cattcaaaaa cccgcctgcg 469141 cgaaacgcgg caagaacgct tgcgatgatg gggattttgc tggcgattct gttttccggc 469201 atcacggttc tcgcgtacgg gtatggtacg gcgccgaaac ctgatgaaac agtggtttca 469261 caaattgcgt ccgaaacctt tgggcggaat gtgttctact atgtcatcca aggtgtcaca 469321 tcgcttattt tggttcttgc ggcaaatacg ggattctcag ccttcccgca gcttgccttc 469381 aacctggcga gagaccagta tatgccgcga atgtttacag tcaggggcga ccgcttaggc 469441 ttctcaaatg ggattatctt tttaggcttt gcctccattg ttctcattat cttattcggg 469501 ggacagacgg agcacttaat cccgttatat gctgtgggcg tatttattcc atttacgctt 469561 tcacaaaccg gcatgtgcat gaaatggatc aagcaaaaac caaaaggctg gatcggaaaa 469621 atgctgatca actcctgcgg cgctctgata tcatttatgg ttctatccat tctgtttgtg 469681 acgaagttta atgtcgtatg gcctgtgtta atctttatgc ctatcgtcgt tttgctgttt 469741 tttgcgatta aaaatcacta tactgcggtt ggtgaacagc ttcgcatcgt agacaaagag 469801 ccggaagaaa tcaaaggcac cgttgtgatt gtgcctgtgg ccggtgtcac caccgtcgtg 469861 caaaaatcga ttcactatgc gaaatcactg tccgatcagg tgatcgccgt tcacgtgtca 469921 tttgacagag aacaggaaaa gaaattcgaa aaacgttggg aagagcttaa taacggagtg 469981 cgtctcgtga cgcttcactc ctcttacaga agccttgtcc atccgtttga taagtttttg 470041 gaaacagttg aggcaaaagc gaagaaggag cagttttccg ttatggtgct gtttccgcaa 470101 tttataacga aaaaacgctg gcacaccatc cttcacaacc aatcggcctt cctcctcaga 470161 gtccggctgt tctggaaaaa ggacataatg gttgccacac tgccgtatca ttttaaaaag 470221 taaagctcta ggaccaaggg aatcaccttg gtccttttta gcgggaaaag gaggtatggg 470281 ggtgtataca caaggtgctt ttgtgatcgt attgaacgaa agtcagcaaa ttctgctggt 470341 gaaacgaaaa gatgtccctc tatgggattt gccgggcggc agggttgatc ccggggaatc 470401 ggctgaggaa gcggcagtgc gggagatatt ggaagaaacg ggatacaatg cagcgctttc 470461 tgcgaaaata ggtgtttacc aaaggccaaa gtttcaagat gaacagcatc tgtttttcgg 470521 aagcattaca ggcggacaag caatggctga cggcacagag acagcgggat taaagtgggt 470581 ttccccgggg cgtttgccgc tttttatggt gccgaatcga aaaaggcaga tcaatgattt 470641 caagaacggc gctcaagatg taaatgtcac cgtcaaggat agcgggttgc tcgcggcgat 470701 cgacctgttg aaaagaagac tgggcaagtg attcaggtct ccgggtttta aagcctttct 470761 cctgtggtat tgaaaaaagg aaaaaggagg atacgttatg gcacacaaaa ctgcaggaca 470821 agcaatgaca gagctgcttg agcaatgggg agttgatcat gtatacggca tccccggaga 470881 cagtataaat gagtttatcg aagaattaag acacgaaaga aatcaactga agttcattca 470941 aacccgccac gaagaggtag cggcactggc agccgcggct gaagcaaaac tcaccggcaa 471001 gatcggagtc tgtctgtcaa tcgcagggcc gggagcggtg cacttattaa atggtttata 471061 tgatgctaaa gccgacggcg cccctgtgct ggcgattgca ggacaggttt cttctggcga 471121 agtcggacgg gactatttcc aggagattaa gctggagcaa atgtttgagg acgtggccgt 471181 gttcaacaga gaggtacata gcgcggaatc acttccggat ctcttaaatc aggcgatcag 471241 gaccgcctac agcaaaaaag gcgttgcggt attgagcgtg tcagatgatt tgtttgcgga 471301 gaaaatcaaa cgggagcccg tgtatacttc accggtgtat attgaaggga acctagaacc 471361 gaaaaaagaa cagctcgtca cctgcgccca atatattaat aacgctaaga aaccgattat 471421 cctggcaggg cagggaatga aaaaggcgaa acgggagctc ttagaatttg cggacaaagc 471481 cgccgctccg atcgttgtta cactcccggc aaagggtgtt gttcccgata agcacccaca 471541 ttttctcggc aacctcggtc agatcggaac aaagccggct tacgaggcaa tggaggaatg 471601 tgatttatta atcatgctcg gaacgtcatt cccgtaccgt gattatttgc ctgatgacac 471661 gccggcgata cagctcgatt cagacccggc aaaaatcgga aaacggtatc cggtgacagc 471721 gggccttgtc tgtgattcgg ctctcggttt gcgcgaattg acagagtata ttgaacgcaa 471781 ggaagacaga agattcctga atgcctgcac agaacatatg cagcattggt ggaacgaaat 471841 tgaaaaagat gagacagagg caacaacacc gcttaaacct cagcaggtcg tggcccgtct 471901 tcaggaagcg gcagccgatg atgcggtgct ctctgtagat gtcggcactg tgacagtctg 471961 gatggcgcgt catttcaaaa tgaacgcgaa tcaggatttc atcgtttcca gctggcttgc 472021 gacaatgggc tgcggcctgc cgggagcgat tgcagcgagc ttgtccgaac cggaacgcca 472081 ggcgatcgcc gtctgcggtg acgggggatt ttccatggtc atgcaggacc ttccgaccgc 472141 cgttaaatat aagctcccga tcacagtcgt tattttaaac aacgaaaatc tcggcatgat 472201 tgagtacgag cagcaggtca aaggcaatat cgactatgtc acaaaacttc aaaatgtcga 472261 ctatgccgca tttgcagaaa gctgcggagc aaagggcatc aaagtgacca aagcggaaga 472321 gcttgcgccg gcttttcatg aggcgctgca ctctgaccaa ccggtcgtag tggatgtcat 472381 gattggaaac gaaccgccgc ttcctggcaa aatcacctac gggcaggcga aaggctttag 472441 caagtacatg ctgaaaaact tcttcgaaaa ccaaaaattt gaaatgccgt cactgaagaa 472501 aagtttgaaa cggttatttt aaaaaaacag gggccctaag agcccttgtt tttttttttt 472561 tttttggaaa caaatgtatt ttcagcatgt ttgaattcat aaaatgatcg gtatatgtat 472621 taggaactga tttcgccata ctcgaaacag acaaaaggac aaatgcatct tgtttcaaag 472681 gaagatgcat ttgtccttgc atgcttattc ttatcaaatc ttacagaact cttctcataa 472741 taggttattt ttcttttttc ttcagcccga agaagaaagg aaaagcagaa ccgaccaaga 472801 aggtgccgaa taaaaacatg ccgccgataa acacgtggaa atttgtgtgt ccggccgtaa 472861 acgccgtgat tagggaaatg atactgagca cgatcatggc aatgccgggc gcgactctca 472921 tttttccctt ggatttatgg gcagcaacag aacataaaat gccgataaca ataggaacaa 472981 tccacaaata aaacagaata aatactgaca tcatcaaaac tccgattttt cttctatcat 473041 aacaaatttc tgtcaaaaag ggtatcaatg agcttttgcg gaaaaataaa aaccggcttt 473101 agaagccggt ttttttatcg aaacgtatct acaattaaaa acacattcaa agcaacgatc 473161 aatacagcaa tcagccaaga caccactgtg atccatttgg cgttgatcag agatcccatg 473221 atccgtttat tgcttgtaaa cataataagc ggaatgaggg caaaggcgat cccgaaggac 473281 agcacgacct ggctcagtac gagagcggtc gtcggattaa cacctgacgc gatgatcaag 473341 atcggcggaa tgatcgtgat aaaacgccgt acatacagcg gaatgcggta gttgataaat 473401 ccttgcataa tcacgtcgcc tgaaagtgtg ccgacagacg aactggatag accggcaacg 473461 agcagcccga tcccgaacaa agccgcagac atagggctga caagatgtcc gaattgctga 473521 aatgcgacgt cgagatcctc aacaaacagg ccgtttttga agaataatgc ggcagccaca 473581 atcagcatac ttgcattaat agcccctgca atcagcatcg ctattaaaat atcaataaat 473641 tcaaacctaa agattttttt ccgttctgca tcagttttgc caaccacccg ccgctgtgta 473701 agggcagagt gtaaataaat ggcgtgcggc ataacagttg cgccaagaat acccgctgca 473761 agaagcacac tgtcggtgcc atgaaacgcc gggacaaaaa ggcccttcat cactgacacg 473821 gcatcaggct ttgcgaaaaa ggtctgcaac gcaaaggcga tcacgaccac aaacagcata 473881 ccggcaatac ctgcttcaag tgagcgataa ccacggcgct gaagctccaa tatcgcgaaa 473941 gaaccgatcg ccgcaataat agacgcttca agcatcggaa tgccgaacag caaatacagt 474001 cccagagccg ctccgataaa ttccgccaga tcagttgcga taatgaccaa ctcgccctga 474061 atccataatc cgatcgagac aggcttcggg aattcttcac gggcaacctc aggcagattt 474121 ttgcctgtcg caataccgag tttggcggat agggattgaa ttaaaagcgc catgatattg 474181 gaaaataaga tcacccataa gagcatatat ccgtatttag aacccgccga aatattcgtt 474241 gcgaagttgc cgggatcaat ataggcaatg gctgctataa atgcagggcc gagaaaaggg 474301 agcagccctc tgaatcctct gattttcccg tcaagcgcat cttggacggc tttggaacgg 474361 ggagattgtg ctgtgatgtc cttgttcatc atgtctcacc tgaattctgt ttgtttttgc 474421 cgtacaacaa agagtttcct taaggcaaat tattttatct acatcatatg accatcccgg 474481 tttcttgtca accgaaaatg ttcaaaatac acttctgaat ttttccctgt tatgtaacat 474541 gatatgtagg gattcgtgat aaggtcccat ataaaaagac atcgtttcat ttcgaaacga 474601 tgcctcctgt atctaatgag tctaggcttc cttccgcagc ccgcggaata taaggcccag 474661 caagaacacg aagatggctg ccccgatgat ggccgggaaa atagcaaagc cggcgaggct 474721 cggtccccat gtgccaagaa gtccgtgccc aatccaagcg ccgatcagcc cggcaatcat 474781 agagccgaaa attcctcccg gcagccggtt tcctacaatg gcgctcccaa ttaatccgat 474841 aacaattgca acaactaatg aaaccaaaaa gctaagcatc atgatcacct ctcataaatg 474901 atttaccaat caataaccgc tcctgatcat ttcgaaacac ttgaaagcat attcctttat 474961 gatcctgttt taatctttct ctgcacactg ccgtcagcta aatgaacaat gacctcagtg 475021 cctttatgcg ccgcgatttc ctttgcccgt tcaatcgctt ctttctttgt atccttgatt 475081 tcagacacac gtttggcgcc ctcggctttg actgcccagc cttttttatg cttaataaca 475141 tgctctgctt tattcatgag ctcggggccg ctgccgctgc ttggatcagc atcgcgttct 475201 gtctcatcat catgcgtcag gaaatcatca atttcatctg tagaggcgtt ttccgcccat 475261 tccttcgctt tgcttgtcgc aattggaatc gcgcgccctt cctcatagcc ttcatcaatc 475321 atcgcattcg caatgtctat cgcctttttt ctcaccggct tctcaagatt ttttaatgaa 475381 gcaggataat ccttcatcga ccaaggcatg tctatcactc cttttccttt tataaaaatg 475441 gtacccgcag gtgaaaaata aaaacgcatc cgaaaaaatg aaggtatact atatagtaga 475501 aaaaacggaa gggaagtgcg ggttgggtgc caacagaacg aaaagaagac ttacatcagc 475561 aattaaaaga gatagagaaa tgggaaaaag atcagcaaaa agtctggttt tgggaaaagc 475621 tcagccgtct cccgtttcaa ctcctggaca agctgacacc agaattcatc cagaaaaaga 475681 tcggcaagct cttggatgag gtcggcagct ttgttcaaac aggcggacag tacctgacat 475741 ctgaaaaaca gattatcagg atgtttcaaa agaaactgcc ggaggagatc tttgaatcgc 475801 tggaggacat ccggaaagcg cctcttcctg tcatggatga aattgcggaa ggaatgggca 475861 aaaacagaac caacgcagca accgttcaag gcgcgacaac cggtgtgggc ggcgtgttta 475921 cgctggcggc agacattccg gcagtgcttg gcttatcact aaaaacatta caggatatcg 475981 cagtcgcata cggctatgac ccaaaggaga aaaaagaacg agtcttcatt gtgaaatgcc 476041 tgcagcttac gtcggctgat gttgtcggca aaagatcgat tttgcaggaa ttaaaacact 476101 acgatcaaga ccgtacatat aagaatgtcg cttctcaaat ccaaggctgg cgagaagtcg 476161 ttttgggcta tcgagacacg tttggctgga aaaaactttt ccagatagtg ccggttgccg 476221 gaatggtttt tggcgccgct gccaatcgct caacattaaa cgacattacc gagacaggca 476281 tgatgctgta caaaaagagg cgcattcttg aacgactgaa agaaacagaa cgagagatgg 476341 aatagcagaa agcagacgga caccgcgatc cgcctgcttt ttttagtgga aacataccca 476401 atgtgttttg tttgtttaaa agaattgtga gcgggaatac aacaaccaac accaattaaa 476461 ggaggaattc aaaatggcag acaataacaa aatgagcaga gaagaagcag gtagaaaagg 476521 cggagaaaca acaagcaaga accatgacaa agaattctat caagagattg gtcaaaaagg 476581 cggagaagcc actagcaaaa accatgacaa agaattctat caggaaatcg gcgaaaaagg 476641 cggagaagcc actagcaaga accatgacaa agagttctat caagaaatcg gtgaaaaagg 476701 cggagaagcc actagcgaaa atcatgacaa agaattctat caagaaatcg gccgaaaagg 476761 cggagaggca acaagcaaaa atcatgataa agaattctac caagaaattg gctcaaaagg 476821 cggaaacgcc cgcaacaacg actaatcaaa agcataaagg cagacaacct gtaaataaaa 476881 aagcgatccg gcacatcagc tggatcgctt ttttttggaa tcttctcaat ttatgccgct 476941 attgagatac aataagtgaa aaaggggttt tcgctaatgt ccaagatgca aaacttgctc 477001 gccatcgcaa atgaagtcaa agaaaagcac gccaattttt caatctcaga ggtcaacgac 477061 cactgcgtgc gccttgcggt gtttacggga gaatatgact ggcaccatca ccctgactca 477121 gacgaattgt ttattgttct tgaaggggag ctgctgatcg attttaagga caaagaaacc 477181 gcggtgctca aagcaaatga cagcctgctg atccctaaag gcacggttca ccgcacacgc 477241 tcttacgtca gaacggtaaa tctctgtgtg gagcataaac aagccgaaac cgtcatcata 477301 gaggagcagc catgctaatc aaaaagatga tatgtgaagt agatgctgca aacgctgaag 477361 catttgcaaa agcgcagtca cagtgggaag cgttatcgca tataagcggc tttatcaaac 477421 aggccggcgg ctggcgaaaa acgatagacg agccgctcac cgcagaaatc atcagtgtat 477481 gggaaaacag agaagcctat gatcatttta tggagaacga acatgacagc atatacgagg 477541 aaaacgatca gaaggctgta attctttcga tagaggtgac ggtgtacgaa gaggataaac 477601 cgttcgttca cgatctgtta cataaccccg atatccggta cgaaccaaac tggacggttc 477661 tgaaggcata atcaaagccc aaaacatcat gttttgggct tgtctcttta ctcgcgtccc 477721 ggaagtgtat tatgaacaaa aggcggtgct ggttttaact ccggtttttc tccaaacgtt 477781 tttgcttctt tcacatattc aaaggcttct ccgtccggcg ctttttcatt cagccagttt 477841 tgctcggcgc ttacttcgcc ttcagagaaa ttgataagct gatgtgagaa ctcttgtttt 477901 tcgagcgctt tcgggaatgt acccggcaca accggacctt cctgtgcttc taattcttta 477961 atggcggcga gccattggtt ctggtgcatc gtgtcacgcg ccagcaggaa gctgagcata 478021 tctttgacgc ctttgtcatc cgtcatttca aacaggcgtg cgacctgcag acggccctga 478081 gattccgcat tcaggttggc gcggaagtct gccagcaggt ttccgcttgc tacgatataa 478141 ccgccgctcc aaggtacgcc tgtactgctt tccggcatgg cgccaagtcc tgatacaatc 478201 gcatggtgag ggttcatgcc gcctaggatg gagccgatga ccggatcttc agcagctttt 478261 tcctgctgat caagaggggc atcctcaaga agtctggcaa tcatcgttgc gatcatttca 478321 acatgcccga gctcctcagt tgccgtatcc atcagcaagt ccttgtattt ttcatttcct 478381 cttgtgttcc agccttgaaa taagtactgc atggcaactg aaatttctcc gaattgcccg 478441 cctaaaattt cttgcatttt tttagcgaat aatggatctg gacgatctgg tttagcagga 478501 tgctgcagca tttttgtgtg cttaaacatg tacccatctc ctttttcgtt tatctctttt 478561 tatatttccg atcgatagaa agataaacga aaaacagcgt atcgagatgg gaactatgaa 478621 tcttttcgca gctccaacag ttcccggatc agctcccggc caaagatggg ctcatactgc 478681 cggtaaacag ggtcaagacg cttcatccat tcttgtttct ctttatctga cagctcataa 478741 atatgtatag cagaattctt tttgatttct tccagctgct ccttgttcat ttgttcggca 478801 tacgtttcat tccactccgt tgtctccttc atcgcttcag tcaaaatgcg tcttgtttct 478861 ggtgtttgcg ccttccagaa gtgttcatca gtcatgacag cgtagccgag ataaccgtgg 478921 ctgcttattg tcaaatagtc ctgaacatta taaaattttt tagaatagat gtttgaaatt 478981 gtattttctt cgccatcgac tacattgttt tctaacagct gaaaggtaga attgaaggat 479041 tcctgatgag gtgttgcgcc aagcagcttg aactgatcct caatcacatc gctttgcata 479101 atgcgcagat cctgcccttt taagtcatcc ggtgttttga ccggcccttg atttgttgtg 479161 atttgcttaa agccgttcgt ccaataggcc aatcctttca attggttttt ctttagagaa 479221 tcaaacagct gtgtgccgat gcttccgttc agcccttttt tgacggcgtt gtaatctgta 479281 aatgcatacg gcagatccag cactccccat tcaggcgaga gcatgccgag cttcgatgtg 479341 gagggggcga taaattgaac atcgccgttt tgcaatgctt caatttcttc aatgtccgag 479401 tacaggcttc cattcggaaa tacttctatt tttatttttc cgcctgattt ttcgttcacc 479461 agatcagcga atttattggc ggccagccct tttggcgtat tttcagcaac cacgtggctg 479521 aatttaaaca cgatttgatc ctgcaggcct tcctggtcgt catcataaac aatcttttta 479581 ttgccggtat gatcatggaa tccgataaat aaagcggttg caattccagc gatcatcagt 479641 gcgagacatg caagcaaact cttcatgaaa agccctcccc tatgttaagg ataatggggg 479701 ctatgacatt cgtaaagacc tgaaaggaga agctgatgaa caaaaagaag ctctcaatcc 479761 gttggaaaat cacgatctta tcctatatac tcgtcatttt ctcctttttg atcggcggca 479821 ttgtgctcat cggcaacatt cagcatacag aggagcggga gctgaaaaag cggctgatga 479881 atacggcccg gacggtgtca gagatgacag aagtgaaaga agccttggcg cgaaaaaaac 479941 aaacagaagc ggttcgccat gcggttgaag aaatcaggat gattaatgaa gcagactata 480001 ttgtcgtcat ggatatgaat cacatccgat atacgcatcc tgtcagcaca agcattggca 480061 agaaatcaga aggtgcagac gaggaggcag cttttgcgga gcacatttat ttctctgaag 480121 caaagggcga gatcggcacg gcggttcgcg ctttttatcc ggtaaaggat caagacctga 480181 accaaatagg cgtggtgctt gtcggaaaaa cgctgccggg gatcgctgac atcctgcttc 480241 atttaaagcg tgatatcgcc ttcatcgttg tgctgacact cggctttggc cttgctggtt 480301 cctttttgct ggcccgccat atcaaaaaac aaatgtttca gcttgaaccc catgagattg 480361 tccgaatgta tgaagaacgg acagcgacgt ttcactcgat gaatgaaggg gtgatcgcta 480421 ttgacaatcg tctcgtcatt acgatcttca atgaaaaagc gaaacagatc tttgaagtgc 480481 agggggatct aatcggcaag gtgatttggg aggttctcaa ggattcgcgc ctgcccgaaa 480541 tcgtggagcg gaacaaagcg gtttataatg aagaaattcg tgtcagcggt aaggtgatca 480601 tgagcagcag aattccgatc gtcatgaaga aaaaagtgat cggcgccgtt gcgatttttc 480661 aggacagaac ggaagcggcc aagatggcag aggaattgac tggtgtcaga aactttgtgg 480721 aggcgctccg tgtccaaaac catgagcata tgaataagct gcacacgatc gccggtctca 480781 tccagctggg gaaatctgaa aaagccttgc agcttgcatt ccaggcgtca actgagcagg 480841 aaaatgtgac tgaatttctg caccgctcga ttcaaaatga cgctgcggca ggccttctat 480901 taagtaaaat cagaagggga agagagctcg gcattgctgt tcatatagat gaaaacagca 480961 gtcttcagca atttcccgag catgttgatc agcatgatat tgtcgtgctt ttggggaatc 481021 tgattgaaaa tgccttcggc tcatttgaaa ccgttcaatc tgaagacaaa cgaattgaca 481081 ttagtatcga acaaacagat gatatccttg ctattttaat agaagataac ggctgcggaa 481141 ttgaaccgac acatatgcct cgcctttatg acaaaggttt tacggtcaat aaaactggcg 481201 gcacaggcta tggcctgtat ctagtgaaac aaatcataga caaaggatcg ggcacgatag 481261 aagttgattc acatgcgggg caggggacat ctttttctat cgtttttcca atgaaggggg 481321 aggaagcaca gcatggctcg taaagaatgg aaggttctgc tcattgaaga cgatccgatg 481381 gttcaagagg tcaataagga tttcattaca actgttaaag gcgttactgt ctgtgcaacg 481441 gcaggaaacg gagaggaagg catgaagctg attaaagaag aacagccaga tctcgtcatt 481501 ctcgatgtgt acatgccgaa aaaagacggc atcaagacct tgcaggagat cagaaagcaa 481561 aagcttgaag tggatgtcat tgtcgtctcc gctgcaaaag acaaggaaac gatctcactc 481621 atgctgcaaa acggggcggt tgactatatc ttaaagccgt ttaagcttga gcgaatgaga 481681 caggcactcg aaaagtacaa gcaatataaa caaaaaatcg aagcgaatga tacgctgtcc 481741 caggaacagc tcgatgcgat cctgaatatt ccgcagcagg ccgtacagga tctgccgaaa 481801 gggttgaatc acttcacgat gaatgaagtc actgcttttt tgaaacagca aaccgcatcc 481861 ctttctgctg aagaggttgc caaggcgctc ggcatcgcca gagtgacagc cagacgatat 481921 cttgattact tagaaaaaac cgggatcatc aaattggacg ttcaatacgg cggagtcggc 481981 cggccggtca accgctacgt gttaaaagga taaacctgag accaaaaaga ccaaaatgtc 482041 cgttatgatc ataaacttcc ccagactgta tgaaaacgct atcattctag taagaaagac 482101 acaaaaggcg aataggacag ggggatgaag gatatgaaac tgtttaaaaa tttaacagtt 482161 caggtcataa ccgcggtcat catcggggtc attgtcgggc tggtctggcc ggatgtcggc 482221 aaagaaatga aaccgcttgg tgatacattt atcaacgctg ttaaaatggt gatcgcacca 482281 atcattttct tcacaatcgt tctcgggatt gcaaaaatgg gcgatatgaa gaaggttgga 482341 aaagtagggg gaaaagcgtt tatctatttc gaggttgtca ccaccctcgc actcattatc 482401 ggtttatttg tcgtcaatat tatgaagccg ggtgcgggtc ttgattacag caagcttgaa 482461 aaaggagatg tatcacaata cacgcaaaat ggcggtcagg gaatcgactg gattgaattt 482521 attacacaca ttgttccgtc caacatggtt gatgccttcg caaaagggga cattttgcag 482581 gtcttattct tttctattct tttcggagtg ggtcttgcgg cattaggcga aaaaggaaaa 482641 agcgtcattg atttcttcga caaggtttct cacgtttttt tcaaaattat cggctacatt 482701 atgcgtgccg cgccaatcgg ggcattcggg gcgatggcgt atacaatcgg acacttcggg 482761 ctcgattcca tcaaaccgct ggcaagctta atgatgtctg tttatattac gatgttcctg 482821 ttcgtatttg ttgctttaaa tatcatctgc aagctttacg gattcagcct gtggaattac 482881 cttcgcttca ttaaggatga gcttttgatc gtgcttggca caagctcttc cgaatcggtg 482941 cttccgcgta tgatggataa aatggagcgc tacggctgtt ccaaatccgt tgtcgggctt 483001 gttattccga cgggctattc gtttaacctc gacggcacat ccatctattt atcaatggcg 483061 actgtctttt tggcacaggt gtttggagta gacctcagca tcggccagca aattacgatt 483121 atcctcgttc tgatgctgac atcgaaggga gcggcaggtg tgacgggaag cggatttatc 483181 gtccttgcct caacgctgtc agcgctgcag gtcattccgc tggaggggct tgcactcctg 483241 ctcggggtcg accgtttcat gagtgaagga agagccattg tgaacctgat cggaaacgga 483301 atcgccacga tcattgttgc caaaagcgaa aatgaatttg atgaagcaaa aagcatagag 483361 gctgttgaag gcatgaaaaa aatgaaaaca gcagtctgaa aaaagaacgg cccatccatg 483421 ggccgttttt ttaattgttt aagaattatt aaggtaagga cagagacctc agcatttttt 483481 tgttatataa tttacaaatg gatactatat tgaatgaagg acgtttgtcc taacaggagt 483541 gtataaatgg ccgctttagt taaatttttt cagcacccgg gagtaaggcg tttctccatc 483601 tttgtcgtgt taactggtgt gttatatcta tttaagagca tgatcaactt aatattgctt 483661 accttcattt tcacatttct aatggatcgt ttggagcttg tcgtgcggca gtttgtaagc 483721 cagttcttcc gcgtgagcca gcgggttgtc attacgtttc tttacatgtt gctggctgtg 483781 ctgcttacag tcgggggctt tgtgttttat ccggtcgtcg cggcgcagat ccagcagctg 483841 gtaaagcaga ttaaacatat tgcgtatcat cctgacagca tccctttctt tgatgagatc 483901 accagtgtct tcggagatat taacatcagt tcatatgtca aagagggctt caatgtagtg 483961 tatacgtatc tggccgatat cagcacattc ggcttgcagg tcgtgatggc gctcattctt 484021 agcatgtttt tcttatttga gaaaaaacgg ctttctgaat tcatggcgaa atttaaaacg 484081 agcaaactta gggtctttta tgaggagatt gcttttttcg gaagcaaatt tgcaagaacg 484141 ttcggcaagg tgctcgaggc tcaatttatc attgcgctcg tcaactgtat tctgacgttt 484201 atcgcgcttt ggattatgca ttttccgcag ctgtttgggc tttcgattat ggtgttcttc 484261 cttggattga tccctgtagc aggcgtcgtc atttccctga ttccgctcag cattatcgcc 484321 tacagcactg gcggtggaat gtatgtgctc tacattgtcc ttgtcatatt cgccattcat 484381 gcgatcgaaa cctatttctt aaatccgaag ctgatgtcgg cgaaaacaga gctgccaatc 484441 tttttcacct tcacagtact cattttctct gaacacttct tcggcatttg gggtttaatt 484501 atcgggattc cgatctttgt gtttctcctt gatattctgg atgtcaccaa caaggaagat 484561 aggtctaaag gaccccgaga gaatagcgat aaaaagtagt ttaaaatcga ataatgagtg 484621 tgcctcgatc tgccggcctg cctgttcagg gcatggaatt aagactcgga atcggagctt 484681 ggcattgcct tgcacagtgg tgaacacaac aggtgacaat gcttgtcatc agtacggaaa 484741 ctgaaaagaa caaacagtcg gagcaaacgc tcatcatcgg tttaaccaaa catttggaag 484801 caacaaatgc tataatacaa acagtgccta atgttgggca ctgtttattt tttgtcgaaa 484861 aaggaggaag gctttatggc tgagccgatt ttacatattg aaggcctcga taaaaaaatt 484921 gggtctaaac agattttaaa acagatcagc atggacgtca tggagggtga aatcatcggc 484981 cttctcggtc cgaatggttc cggaaaaaca acactcatcc gtatcatcgt cgggctgttg 485041 aaacaaaaca gcggaagcgt gacaatcagc ggattccagc atgatacaga gtttgaaaaa 485101 gcgatggaag cggttggagc gattgttgag aaccctgagt tctatccgta cctgacaggc 485161 tgggaaaacc tcaagcactt tgcgaatatg cacaaaaaaa tagcggatga acggcttgat 485221 gaagtggtgg aacgtgtcgg gctgacgtca gcgattcatg ataaggtgaa aacctattcc 485281 cttgggatgc gccagcgtct gggaatcgcc caggcaattc ttcaccggcc gaagcttctc 485341 attctagatg aaccgacaaa cggcctcgat cctgcgggga tgaaggattt tcgggatcat 485401 attaaggaac tcgcagaaat ggaaggaaca gctgtcctgt tcgccactca tttattgcgc 485461 gaggttgaag acttgtgcga ccgtgtcatc atcattcaaa aaggtgagat caaagcggaa 485521 gtcagcttac aaggaaccga tcaaaccaca gaaaaagcga ttatagaagt gcagccgcaa 485581 gaaaaagcgc tcaattggct gacaggcaat caatatcaag ctgagagcca agacgggacg 485641 attgtagttg aggtggcaaa agaaaacata ccggagctga accgatcact tgtcggacaa 485701 gatctgaatg tattttccat tacgccttac acgcagtcac tggaagacga atttataaaa 485761 gcgacaacag ctcatcaaga ggagggagaa gagcttgtct aaattaattt ggaatgaaca 485821 tatgaaactt tttaatcgga aggtcacttt ggtttctctt atcctgatgg ctgtctttca 485881 attcttcatg gcattgatca ttaaacggat tgtcatcagt gccggaacag atgaaaactt 485941 catcggctat ttatcgtata caccgagcct gaacattttg ctgcaggctt taacgatcgt 486001 aattgcagca acaattgttt cgatggaatt tgataaaaag acgatcaaat ttttgctcat 486061 tcgtccggtt aaacgccaaa aggtcttttg gtcaaaatta atcacagtcg tgatggtcag 486121 cttctatttg tatttggcat actacattct ggcattatta ttcggtctct tgttttttgg 486181 cacatcggtg actgcggaat caaagacatt gctggtcaac accttggcgc tgatcgggtc 486241 aaactggctt gaagctgtaa tgatgggatt attcgggctg ctttgttctt cgctgttccg 486301 caatagcgcg gtagcagttg ttgtttcttt tgtcgtttta tacggagcga gtacacttgt 486361 tcagctcatg aagttgtttg aaaacaagtg gggcagcttt ttgctttttg cgaacactga 486421 ctttacgcaa tacagaagcg gagagacagc gttgttttca ggcatgacgc cattgttttc 486481 aattggaatt ctcatcatac atgccatatt cttcatcgtt gttggctggt ggtgcttctg 486541 taaacgggat gttcgggtct aaaggcaagg aatgacattt ttgtgaaaaa gctcacgtaa 486601 atcaatatca tttgatattt tggtttatac taaaggtact gacggaggtg tctcgattga 486661 ggaactttat taccgcttta ccgatcgtat tgctgcttgg attctcattt gtgtcattca 486721 tgtttcagtt tgaacatctt gtttatttca ggctcgcgct tgggttgttt tctctcgtgg 486781 gactgtacat gatatataaa atgaagacgg gcatccgcta ttttatcatc tatctgtatg 486841 ccagctggat tgtgttggcc gcagtgaccg cttttgaaga gccgattttc tcaagctttt 486901 tctttggcgg cctggtgatg acgatgggtt acctgacata tatgctgatt tatctcggca 486961 tgaaacaaga ccgggatgca aatcctgtgt aatcgcgctg ttcccttggg gaacggcgtg 487021 tttttctata ctgggcaaaa ggttaacagt tgcggaaaaa tggcaggaaa tctataatac 487081 atattaaatt tatcggaatt aaaactgggg ggctgccgga tgtcattatt tatacaaaac 487141 gatcaacagc ggcaatggat ggagaaaatc ggacggattg cggatgaatt tcagcaaaca 487201 gctgctgaag atgacgaaca gggacgtttt cctgcagaga aaatacaaaa actgcgtgat 487261 gctgggtata cagcattaac attgccggca tctcatggcg gagggggcat ttctgtttac 487321 gatatgctct tgtttcaaga acggcttgca cggggagatg ctccgacggc tcttagcatc 487381 ggctggcatt tgagcgtgat cggggagctt ggagaaggca acagctggga tgaagacgta 487441 tttgcatttg ttgccaagga agtccaaaac ggagccgtca ttaacagggc ggcgactgaa 487501 gcgaaaaccg gaagcccgac aagaggaggg cgtcccggta cacacgccgt caaaaaggat 487561 ggcaaatggg cagtgaacgg gagaaaaacc tttacgacga tgtcacaagc tctggattat 487621 tttttagtaa ccgcatggat tgaggacaaa caaacaacag gcgtgtttct cattcataaa 487681 gatgatcccg gcttgtcgat tgaagaaacg tgggatatga tggcgatgcg ggcgactggg 487741 agccatgacc ttgtactgaa cgaagtaatg cttgatgaga ataagctggt ggaactgctt 487801 caagggcctc gtggagctaa gccgaatggc tggctgcttc acattcctgc gatttatctt 487861 ggtgtggctc aagctgctcg tgactatgca gtgcaatttg catctgagta ttctccaaac 487921 agcttgaatg gaccgatcaa gaatgtcccg gccgtacagc aaagaacagg cgaaatggag 487981 cttgaactgc tcaatgccag acactttctt ttccatatcg ctcaattgta tgacgatccg 488041 gtgcggcgtc cacacttgac cagcgagctc ggtgcggcga aacatatcgt cacaaacgct 488101 gcgctgtctg ttgttgataa agcgatgaga attgtcgggg ccaaaagcct ggaacgaacc 488161 aacccgcttc agcgctatta ccgtgatgtg cgcgccggtc ttcacaaccc gccgatggat 488221 gacgccgtga tacacaagct ggcagctgaa gcgtttgagt cataaaaaaa agagccttac 488281 cggctctttt tatgtattgt tttgctcttg cagatttttt tgatgcttgc ggtcgatcct 488341 gtcataaata acgttcatca gctttggatt gcccataatc gcctctttgt tttcctggat 488401 cagctgttgg taagttttca ctttacgctt cggcatgctc cggcgccctc ctgacatgtt 488461 tgtattcact ttctaactcc gtcagcgaca attcatacag atgacgcttt gactttttgt 488521 atataccatt ctgtattaac agatgaatga gctgtttttt tctgatttct gcagactgag 488581 gtgtcattgt gtcaccaacc tccaatcaaa cgatattgat aatcattatc aattaacttc 488641 agtatacaat gtccgcaata gcctgtaaag atgaaaagag tcctattctt ggccaattta 488701 caaacattca acaaatcgac aaaaagtttc ccgggcaata atttgctgtc gaaatattcc 488761 gcttcattga acgcaccctg ctatttttca tgttttgaac catactatgt aatagaatgg 488821 aggctggtat tcaatggagc ggacagaaaa tctgaaaaag ggagaaaaag gggcgctcct 488881 caatattttt gcatatgtca tccttgctgt tgtaaagcta gttatcggga ttctatatca 488941 ttctgaagcg ctgagagcag acgggttaaa taatggaaca gatattgttg cgtcagtagc 489001 agtgctgata ggattgcgga tttctcaaag accggctgac agcgatcatc catacggcca 489061 ttatcgggct gaaacaattt cgtctcttgt tgcgtctttt attatgatgg cagtcggcat 489121 tgaagtgtta atcggcggag gaaaagcgat tgcgggcggc acaacggaaa cgccaaatct 489181 tatcgcggca tggacggcgt taggcagtgc tgtgtttatg tatggcatct atttatataa 489241 caaaaggctg gcagcgtcca ttaaaagctc tgccctgatg gcagcggcaa aggacagcag 489301 gtcagacgct tttgtaagtg ccggcgcgtt tatcggtgtt ttttcgtccc agctgaagct 489361 gccgtgggtt gatccggtaa cggcttttat catcggcatc atcatttgca aaactgcgtg 489421 ggatatcttt aaagacgctt cacattcctt aacagacggc ttccatttaa aagatcttga 489481 gccttacaaa cagaccgtcg gcaggatcga aaatgtgcat cgcctaaagg atgtgaaagc 489541 gaggtattta ggcagtacag ttcatatcga gatggtgatt acggttgatc cgaagcttac 489601 agtagaagaa ggccatggag tggcggatga agtagaagac aaaataaaac atgaacacga 489661 tgtcactcat gttcatgttc atgtagagcc tgacgacata aaataaggct gtttaacgaa 489721 ttagcttata tgttcagata aaaattcagt cacttcttca ggcgttttgg cattggcgct 489781 gtgaaggtga gctgtttttt caccgttctt gaaaataagc aggctgggaa tgcccattac 489841 ttggtatttt tcagccaggt caggaagctc gtccttattc agctcatacc agtcgttttg 489901 gttgtattct tccaaaatat cgccgatgaa catattcatg cgtgtgcagt ctgggcacca 489961 atcagcataa aactttacaa tgatttcttt atcagattga atcagttcat taaattgttc 490021 gtttgttgtg atttttttca tatgtcacat ctccttttca atgccatttt aatataaaat 490081 aaaaaggaat tacatacaaa tgcattcaac atcagcatgc ccaaaaataa ttagatcatt 490141 ttccggtgaa aatgataaga tagtaaagat gaattgtagt ggggggagta tccattgaaa 490201 acaagtctag gattagtgta cggaggaaag tcggcagaac ataatgtttc cctgcagaca 490261 gctctggctg taatcaaagc gctaaatact gagaagtttg atatacatcc gatttatata 490321 acagaaaaag gcgaatgggt tagaggcgcc cgtttaactg aacctgtttc aaacgtgaaa 490381 atgcttcaat ttgagcaagg aggcagtgct ttttctccag ctgccctgaa ccaggagatg 490441 tttccgcagg aagcgtcaca gcaaaatgaa gccatcgacg tcgtattccc gctcctccac 490501 ggaccgaacg gagaagacgg tacgatccag ggaatgctcg agctgttgaa cattccttat 490561 gtcggcaacg gagtgcttgc ttcctcagct ggcatggata aagttgtcat gaaacattta 490621 tttgcgcagg ttggccttgc tcaggctaaa tacgcagctt tccttaagaa agactggact 490681 cgttctccga aagaaagctg tgaggaggtt gaacaggaat taggctaccc ttgcttcgta 490741 aaaccggcga acctcggctc aagtgtcgga atcagcaaat gccgaaaccg tgaagaactg 490801 caaaaagcgt ttgagcttgc tttccaatat gaccgcaaag tcgtcgttga agaaggaatt 490861 aacggccgcg agatcgaaat cggcgttctt ggaaatgatg atcctaaatg ctctgttgtg 490921 ggagaaatcg caccgaagac agatttctac gattacaaag cgaaatatga ggatggagat 490981 actgatctga tgattccggc gattgtgact gatgaggaat acgcaacaat cagtgatatg 491041 gcgatcaaag cgtttaaagc gatcgacggt tcaggactcg tcagagcgga ctttttcctg 491101 acagctgacg gcgaagttct gatcaatgaa gtcaacacaa tgcctggctt tacacctttc 491161 agcatgttcc cgttgctctg gaaagaagcc ggagtggaat atgctgacct gattgaacag 491221 cttgtggagc ttgcaaaaga acgccacgct gaaaaacaat tgattaagca tacattctaa 491281 tgaagaagga cactgccggt aaaagggcag tgttttttcc cgtatataca aaagaaagag 491341 agggacctta cttgattaag cgaacagtaa aaaacattgc cgaaatggtt aaaggcacac 491401 tagcaaatcc gcaatatgaa caaacagtca ttcatggagt ggcaaccgat acaagaaaac 491461 tggaacaaca tcagctcttt attccgctga aaggggaacg ttttgacggc cactcttttg 491521 tggagcaggc ctttgaagct ggtgtagcgg ctgttctttg ggatcggtca gtaccaaatc 491581 cgcccgagaa tcacgccgtc attttagtgg acgataccct tactgcactt cagcagcttg 491641 caaaagctta tttgcaggag cttggcacgc gtgtcatcgg agtaaccgga agcaatggca 491701 aaacgacaac aaaagatatg attcacgccg tattggggac ccagtaccgt gtccacaaaa 491761 ctggaggaaa cttcaataat catatcggtt tgccgctgac ggttttagcg atgcctgaaa 491821 atacggagat cgccgtattg gagatgggaa tgagcgccaa aggagaaatt gacctcttga 491881 gccgactggc aaacccggat gcggcagtga ttacgaatat cggcgaatcg catatgcaag 491941 acctcggctc tagagagggc atcgcggagg cgaagcttga aatcataaac gggcttaaag 492001 aagacggagt gctgatttat atcggggacg aaccgcttct tcaaaatgca tacagctgcc 492061 agacgaaaac gtacggtacg ggaacgcata atgattatca gcttcaggat gtcagccaga 492121 gtgaggaagg aacccatttt acaatcaaag ggatagaaaa cacgtttttt attccaatac 492181 tcggcaagca caatgtgatg aacgccatgg ctgcaattgc tgcaggggct tattttggca 492241 tcgcgcctga ggatgcggca aaaggactga gcggcctaaa ggtaaccggg atgaggcttg 492301 aactcatcaa aacagacagc ggcctttcga taatcaatga cgcttataat gcgagcccga 492361 cttccatgaa agctgcaatt caattgacag aaagccttga aggctacggc aaaaaaatgc 492421 tcgtgctcgg tgatatgctt gaactcggcg atcttgaaga aacgttccat aaagagtgcg 492481 gcgctgtgat cagccctgat aaaattgacc gcgtctttac gtacggaaaa ctgggagctt 492541 ttatcgcgga aggcgccctg aaacactttg agaaagaccg cgtcagccat tacactgaga 492601 aaaaagatct ccttcaagct gtgaaggaaa acgcatcaaa aggcgatttg attttattca 492661 aagcgtccag aggtatgaag cttgaagaaa tcgttaaaga tttaatagag agcccgcttt 492721 cataagaaaa tattttgcga aaaaacgcat attgcatcat aaaataacct gatatgcaaa 492781 cactaatgta tgccggccga aaattatgta tatctggccg gctgcggcta tgatacaata 492841 tatataggtt atttcgcgat acgaacatat tcgtccggac ttttcatcgt gacccgaagt 492901 tctccgctgg attcttggga gcggatggag cagcagccgg catattcgag atgccgatct 492961 gcttctcatc ttattgaaaa acaaatagtg taatggtaag ataaaactta aagtaattcg 493021 ggctttgtat acggatggat cctgtccttc ttgtctaaag ggcagtttta taagtggtaa 493081 atcacgacat tactgaaaca gcaattagaa ggagtttgaa taatttgact ataacgtttc 493141 aagattttaa tttaagttct gatctcatga aagcaattaa tcgtatggga tttgaagaag 493201 caacaccgat tcaggcacaa acgataccgc tcggactttc aaataaagac gtcattggac 493261 aagcgcaaac aggtacaggt aaaacagctg cgtttggtat accccttgtt gaaaaaatta 493321 accccgagtc tcctaatatt caagcaatcg taatcgcgcc aacccgtgaa ttagccattc 493381 aagtatctga agaattgtat aaaatcggac aagataaacg tgcgaaggtt cttcctattt 493441 acggcggaca ggatattgga cggcaaatcc gggcgttaaa gaagaatccg aatattattg 493501 tcggaacacc tggacgtctt cttgaccaca tcaaccgccg caccattcgt ttaaacaatg 493561 taaataccgt tgtaatggat gaagcggatg aaatgctgaa catgggattc attgacgata 493621 ttgaatctat cctttcaaac gtgccaagcg agcatcagac acttctgttc tctgccacaa 493681 tgcctgcgcc gatcaaacgc attgcagagc gcttcatgac tgagccggaa cacgtaaaag 493741 taaaagcgaa agaaatgacg gtttctaaca ttcagcagtt ctatttggaa gtgcaagaac 493801 gtaaaaaatt cgatacactg actcgccttc ttgatattca gtctcctgag cttgcgatcg 493861 tattcggacg tacaaaacgc cgtgtcgatg agctggctga agctctgaac cttcgcggat 493921 atgcagctga aggtattcac ggtgacttaa cgcaggcgaa acgtatggtt gcgcttcgta 493981 aatttaaaga aggcgcaatc gaagttctag tcgcaactga tgttgccgct cgcggacttg 494041 atatctcagg tgttacacac gtatacaact tcgacgtgcc tcaagatcct gaaagctacg 494101 ttcaccgtat cggaagaacg ggccgtgcag gaaaaacagg tatggcgatg acgttcatta 494161 caccgcgtga gaaaagcatg cttcgcgcaa ttgaacaaac aacaaaacgc aaaatggacc 494221 gcatgaagga gcctacactt gatgaagcgt tagaaggtca gcaacaggtt actgttgaac 494281 gtcttcgcac aacaatcagt gaaaacaacc tgaacttcta catgacagcg gcagctgagc 494341 tgcttgaaga tcatgatgca gtaacagtgg ttgcggcggc tatcaaaatg gctacaaaag 494401 agccagacga cacaccggtt cgcttaacag acgaagcgcc gatggtcagc aaacgctaca 494461 agaaccagcg ctcttctaaa cgcagagacg gtcaaggcgg cggctaccgc ggcggaaaag 494521 ggaaaagcaa caaccgttct tcctatgaca aaaagcgttc aaacgatcgc cgttcttcag 494581 gtgacagacg ccagaaaaaa tcttactaat ttgatcgatt cagagcccaa aacatgatgt 494641 tttgggcttt tttatgttcg tgatttgtta ttcagcaaac tttcagctga cggaagccat 494701 ttttctctgt atgcttaaga atgaaacctt tctgtaaaag agacgtataa ataacgacga 494761 aaaaaaggga ggtaggtatt tttgagagag cagccaaaaa accaaatcag tccagacgga 494821 ttaaaggttt ggcgacttca agagatcatc atatccgctg tttgcttgct tattgtcatt 494881 gcagttgcag tgttaagcta ttattttcat tggccgtact ggatcagcgg cgtgctcggc 494941 gctgtttggc tgctgggatc gattgtgacg gtctttatca ttccgaaggt ccgtcataag 495001 gtgtggcgat atgaagtcca tgaacatgaa atagatattc agtcaggtat ttttgtggtg 495061 acacgtgtga ttgttccgat ggtcagagtt cagcacgtcg atacgtcaca agggccatta 495121 ttaaaaaaat acaacctggc aacggtgaaa atttccacag ccgcgaccgt tcattcgatc 495181 cccgctttag agatggagga agcggatcgg ctaagagact ccatttcccg tctggcgagg 495241 gtgactgacg atgatgtctg aaccgaaacg cctgcacccg gtggcagtca ttttgaattt 495301 atgccatacc attattcaaa cgataaaaaa tatcattctg ccattctttt ttgtgtatat 495361 tgtcaattca aaccatactg tccgttttta cggagccatt gcgctcggtg tgctgttcat 495421 ctggcttgta gcggcaagca ttatcaaatg gagaaggttt acctatcgaa ttgaagatga 495481 tgaatttaga attgaagaag gcttatttgt tacgaaaaaa cgatacatat cgattgatcg 495541 gattcaaaca atgaatacga gcgcgggcct tgtccagcaa atctttaagc ttgtgaagct 495601 gcaaattgaa acagcaggcg gaggcaagga ggcagaagcc gttctttctg ctatttctgt 495661 tgaagaagcg gaacgcatca aagaagctgt ctttaagaaa aaagcgcaaa gacgagaaaa 495721 tgaacttgat gaagaacggc ttgaagctga agaggagttg gatccgtccg ttgaggtgca 495781 agagcactat cgcatgaacg cgaaagaatt gctcatggcc gcttctacct ccggcggaat 495841 cggagtcatt atctccgctg tatttgcact tatttcccag cttgatgaag tgctgccgat 495901 ggattggtta ttcgataaat tttccttcct tcagcacgcc agcatcggta tttatgcggt 495961 actcattttt atcggtttat ttatcgcctg gattttcagc atcgcgggca tgatgtttag 496021 atacgcgaac tttcaaatca taaaaaaaga gcaggaactg gtgatttcaa ggggaattat 496081 tgaaaaacat caagtcacga ttccgctgcg aaaaatacaa gccattaaaa tcaaagaaaa 496141 tatcattcgc cagcttttcg gctttgtaac ggtgtccatc gtcagcgcag gaggcggcga 496201 ccgggaaaaa gaagaaggcg ctttgaccat tctctttcca atgattcata aaaaaaagct 496261 tccgcacatg ctccgaacat ttacgccgga atacacgctg gaagaaaact gccgccgcct 496321 gccgcggcgc gcgttgaaac gctatttgtt ccgttctgtc attttttcac tctttttgat 496381 catcccgtta tgtatcttct ttcagccatg gggctatctg tcagtgatcc tgctgccgat 496441 agaattgctc ttcggctatc tcgcgtataa agaggctgca tggacgatca acggggaccg 496501 tcttcagctg acgtctagat ttataggcag aacaaccgcc attgtactga aaaaacgaat 496561 gcaggtctgc aagttcagcc aatcctattt ccaaaagaaa ggccgcttgt ataccatttc 496621 tacttcggtg aaatcatcga gccatatgga agagttaacg gtgagggacg taggtgaaga 496681 ggatgcagcc ttcattttaa agtggtactc atatgaaaaa gcggacggtt aataccgccg 496741 ctccagcgtg tcggcaaacc ctcgcattcg ttgtcaggac tgcgcttcgg tgctcaatgc 496801 gaagtggatc aacggctaaa ttctcaggcg tcctgcctaa acgccgtcgt catcacatcc 496861 tgtgaaagtc cgctcctatg ctcgtccttc ctagacttca tgggttttca atcacgctga 496921 aaagatgaca aaatcctaaa atgaaaacca ttttaggatt ttgtcaacaa tctgaagcgg 496981 cggttaatac cgccgctctt ttttttgcac gcataaaaac gaaagaagaa acccgccgca 497041 tagtccaaac aaatgggcca tcatgttaat attggagttg ataaacgaca tgagaacggc 497101 aaatgcgagc agtgtgatga tcattttgga atgctcctgc ccaattaact cattgcgaaa 497161 aagaaccata aacaggtata cgccaaatag cccgaaaatg gcgcctgaag ccccgacatg 497221 cacgtaatca agcggctctg taacataagt gccgatattg ccgatgatgc cggagccggc 497281 gtatacaaga aggaaacgcg cttttcccag catgcgttcc aaagccgggg caaataaaaa 497341 gatggacatg gaattaaaca gcagatgtgt gaaaccggcg tgcagcaaaa tcggtgtgat 497401 aagccgccac cattcaccgt ttgcgacacc tagattatag cctgtgacgg tatccctcca 497461 taacacgact gaatgggcag gaagtgaaaa aaacagccag agaacagctt gcaaagccaa 497521 tataaaggtg acaacggggt aaagcctgat aaatgtttga aaattttcag tccgtataaa 497581 cattccgagc cccttttctt cattttggta tatctatagt aacacgttta tgagacaaac 497641 catttaaata gtacgtacgc aaaggaggtt atcatacatg atttacggca ttgggctgga 497701 cattaccgag cttaaacgga tcgcctctat ggctgggcgc cagaaaaggt ttgccgagcg 497761 gattttgacg cgaagcgagc ttgaccaata ctatgagctt tcagagaaaa gaaaaaacga 497821 atttctcgcg ggcagattcg cggcaaaaga agcgttctcg aaagcatttg gcaccggcat 497881 tgggaggcag ctcagctttc aggacattga aattaggaaa gaccaaaatg gcaagcccta 497941 tatcatttgt acgaaactga gccaggccgc cgttcacgta tcgatcactc atacaaaaga 498001 atacgctgcc gcgcaggttg tgattgaaag gttgtcaagc tagtctgcat attagggaaa 498061 ccccactcat atatttgata gtgcattaag ggagacaagt tgtttgaggc ttttatggta 498121 cgcatctgtt ctgcctaaac gtgtaccgag cgtaccgtta aagtcaaaca agcgatttct 498181 tccttttaca tcaattgaga aaaaggggtt gaaaaaggtg agaaaaagct ttgttttgct 498241 tttaacggga ctgcttgctg ttcttattct ttctgcctgc gggcaaaaaa cacagcaaga 498301 tattgtggcc gggttagatg aaaaggcgaa agaatacacc tcgtacaaag caaaagcgaa 498361 aatgaccatc gagacaggga gtgagcctca agtatacaat gtggaaatct ggcacaaaaa 498421 gccgtctctg tacagggttt atttagaaaa tccgaaaaag gaccaaaacc aagtcatttt 498481 acgaaatgaa aacggagtat tcgttctcac gccgtcttta aataagagct tcagatttca 498541 aagcgattgg ccgaacaaca gcagccaggt ttatctgttt gaatcgctcg taaaggatgt 498601 tcaaaacgat tcggatgcag ttttcacagc gaaagaaaag aaatacgtat ttgaaacaaa 498661 aacaaactat cagcataaca aaatgctgcc cacgcaagaa atcacattta acaaaaaaga 498721 tatgagcccg tcatctgtca aagtgatgga tactgaccgg aaagtgatgg tcaaagtaga 498781 attcagcagc tttgaattta ataaacaatt tgataaagaa tcatttgatg aaaagaaaaa 498841 tatgaccctt tctcaaatgg atgtcgccac aagcgcaaag ccttccgata catttgcggt 498901 caaaacgccg ctggaactgc cgcttggcgt caagctgctt gaagaaaaag atatatctac 498961 tgaagacggg aagcgcatca tcatgacgta cggaggagaa aaatcattta cgttaattca 499021 ggaaaaagcc cagattgcca aggcttcctc ctccgttacg ctgaacggcg aaccggtaaa 499081 tctcggctac accatcggcg ccctgtcgga tgcatcatta tcatggacat atgacggcgt 499141 agattacctt ctctcttcta aagatctttc taaagaggaa atggtgacag tagcgaaaag 499201 catgcaggga caatcatcga aataaccgcc aaaggccaaa catgatttgg cctttttttc 499261 gttagacatc gtttcccttt agcctttaat tttagtatga tatgtaaatg atattgaata 499321 aaagctagga agtgtcgtaa tgagcacaaa acctttttac agagatacgt gggcggaaat 499381 tgacttgtcc gcgataaagg aaaatgtcag caatatgaaa aaacatatcg gtgaacatgt 499441 ccacttgatg gcagttgtga aagcaaacgc ctacgggcat ggtgatgcag aaacagcaaa 499501 ggctgctctt gacgcaggtg cttcatgctt ggccgtggcc attttggatg aagcgatttc 499561 actgcgcaaa aagggattga aggcgcctat attggtgctt ggcgcggttc ccccggagta 499621 tgtggcaatc gctgctgagt atgacgtgac cttaacaggt tattctgttg aatggcttca 499681 ggaggcagcc cgccacacga aaaaaggttc tcttcatttt catctgaagg tcgatacggg 499741 gatgaacaga cttggtgtaa aaacagagga agaagttcag aacgtgatgg caattcttga 499801 ccgcaaccct cgtttaaagt gcaaaggggt atttacccat tttgcgacag cggatgaaaa 499861 agaaagaggc tatttcttaa tgcagtttga gcgctttaaa gagctgattg ctccgctgcc 499921 gttaaagaat ctaatggtcc actgcgcgaa cagcgccgct ggactccggc tgaaaaaagg 499981 cttttttaat gcagtcagat tcggcatcgg catgtatggc cttcgcccgt ctgctgacat 500041 gtcggacgag ataccgtttc agctgcgtcc ggcatttacc ctgcattcga cactgtcaca 500101 tgtcaaactg atcagaaaag gcgagagcgt cagctacgga gccgagtaca cagcggaaaa 500161 agacacatgg atcgggacgg tgcctgtagg ctatgcggac ggctggctcc gaaaattgaa 500221 agggaccgac atccttgtga agggaaaacg cctgaaaatt gccggccgaa tttgcatgga 500281 ccaatttatg gtggagctgg atcaggaata tccgccgggc acaaaagtca cattaatagg 500341 ccggcagggg gatgaatata tttccatgga tgagattgca ggaaggctcg aaaccattaa 500401 ctatgaggtg gcctgtacaa taagttcccg tgttccccgt atgtttttgg aaaatgggag 500461 tataatggaa gtaagaaatc ctttattgca ggtaaatata agcaattaac ttacctaaat 500521 ggagaattca taaaacagct ttgcttgaag agtgaataat ggtatcatta tcactggatg 500581 gataaaagag tcgtatccgt aagtttggtg gaggtgtatg ttttttgtct gaatccagcg 500641 caagaaccga aatgaaaatc agcttgcccg aaaacctagt agctgaattg gatggtgtag 500701 cgatgcggga gaaacgaagc agaaacgaac tgatatcaca agcagtgaga gcgtatgtca 500761 gcgaacgaac aactcgtcac aaccgtgatt tgatgagacg cggctatatg gaaatggcga 500821 aaatcaacct gaatatttct tctgaggctc actttgcgga gtgcgaggct gaaacgacag 500881 ttgagcgctt agtcagcgga ggataatcat ttgattgtga aacgcggcga tgtttatttt 500941 gctgatttat ctcctgttgt tggctcagag caaggcgggg tgcgcccggt tttagtgatc 501001 caaaatgaca tcggaaatcg cttcagccca actgctattg ttgcagccat aacagcacaa 501061 atacagaaag cgaaattacc aacccacgtc gaaatcgatg caaaacgcta cggttttgaa 501121 agagattccg ttattttgct ggagcaaatt cggacgattg acaagcaaag gttaacggat 501181 aagattactc atctggatga tgaaatgatg gataaggttg atgaagcctt acaaatcagt 501241 ttggcactca ttgattttta gacatatttg caggttgctc aaatagagca actttttttg 501301 ttttcaaaaa acataaacga tataatagtg aaataacgaa aaaatatgtt gttttttatt 501361 gggaggtaag cgaatttgat gtcgaaccag actgtatacc agttcattgc cgaaaatcaa 501421 aatgaactgc tccaactgtg gactgacaca ctaaaagaat taagcgagca agaatcctat 501481 cagctgactg accaagtgta tgaaaatata tctaaagaat atatcgacat tctgctgctg 501541 tctgttaagg acgaaaatgc tgctgaaagc caaatcagcg aactggcgct tcgagcggtc 501601 caaatcggac tgtctatgaa gtttttggct actgcacttg ccgaattctg gaagcgtctc 501661 tacacgaaaa tgaatgataa gagattgcca gatcaagaga gcacggaatt aatctggcag 501721 attgatcgct ttttcagccc gattaacaca gaaattttta atcaatactc aatctcatgg 501781 gaaaaaacag tatccctgca aaaaatcgcg ctgcaagagc tgtctgcgcc gcttatcccg 501841 gtgtttgaaa atatcactgt gatgcctctt gtcggaacaa ttgataccga acgcgcgaaa 501901 cgaattatgg aaaaccttct taatggcgtc gtcaaacacc gttcccaagt cgtgctgatt 501961 gacattacag gtgtccctgt cgtcgatacg atggttgccc atcatattat tcaggcatca 502021 gaagctgtaa ggcttgtcgg agcaaaatgc ctgctggccg gaatccgtcc ggaaattgct 502081 caaacaatcg tcaacctggg gattgattta tcccaagtta taactaagaa taccctgcaa 502141 aaaggaattc aaacagcatt ggaaatgacg gatcgaaaaa tcgtttcatt gggggaataa 502201 cattttgaga catccgaaaa tcccgatctt gaaactgtat aattgcttat tagtgtccat 502261 tcagtgggaa cttgatgacc agacagcatt aacttttcaa gaagacttat taaataaaat 502321 atacgaaaca ggtgctaacg gagtcgtcat tgacctgaca tctgtggata tgattgattc 502381 atttatcgcg aaagtgctgg gggacgtcat tacaatgtct aagttaatgg gggctaaagt 502441 cgtcttgacc ggcattcagc ccgctgtggc agtgacgctg attgaacttg gaatcgcgct 502501 tgaggaaatc gaaactgcgc tcgacttaga gcaggggctt gagacattga agcgggaatt 502561 gggggaatag cgaatgaacg accaatcctg tgtaagaatc atgacagaat gggatattgt 502621 ggccgccaga cagctgggac gaaacgttgc gaaagaactg ggtttcggca cggtagacca 502681 ggctagaatt acaacggcta tttcagaatt agccaggaat atttatttat atgccggcaa 502741 agggcagatt ggaattgaac aggtcgcaga cagaggaaaa aaaggcctga aaatcatagc 502801 ggaagaccaa gggccgggaa ttcctgatat ccgaaaagtc atggaagacg ggttttcaac 502861 gtctggagga cttggtgcgg gacttcccgg ggtcaaaagg ctgatggatg aattcagctt 502921 aaattccgta gcgggggaag gaacagagat acaagccatc aaatggcttc ggtaggaggt 502981 aagaacgtgg attttaggga ggttattgag cagcggtatc atcagctgct tagtcgatat 503041 atagccgaat taacagaaac atctttatat caagcccaaa aattcagccg aaaaacaatc 503101 gagcaccaaa ttcctccgga agaaatcatc agcattcaca gaaaagtgct gaaggagctg 503161 tatccaagtc tcccggaaga tgtgtttcat tcgctggatt ttttaataga agtcatgatt 503221 ggctatggaa tggcttatca ggagcatcaa acccttagag ggatacagca ggaaatcaaa 503281 tcagaaattg aaatcgcggc aaatgtccag cagacgcttc tcggaactaa agttcctcag 503341 gaggaagcgc tggatatcgg cgccatcagt gttcccgcta aacagatgag cggtgattac 503401 taccactttg tcaaagacaa ggaatccatc aatatcgcaa tcgcggacgt gatcggaaaa 503461 ggcattccag cggctttatg catgtccatg attaaatacg caatggactc tttgccggaa 503521 acgggcatac acccttctca agtgctgaaa aatttgaatc gtgttgttga acaaaacgtt 503581 gatgccagta tgtttattac gatgttttat gcgaattaca atatggacaa gcatcaattt 503641 acatatgctt cagcgggaca tgaaccggga ttctattatt ctcaaaaaga caacacgttt 503701 tacgatttag aggccaaagg actcgttctc ggcatctcgc aggactatga ctacaaacaa 503761 ttcgatcagc atctggaaaa gggcgatatg attgttttat tttctgacgg cgtcacagaa 503821 tgcagaacgg aaaacggttt cttggagcgt cctgatctgc agaagctcat tgaggaacat 503881 atgtgttcct ctgcgcagga aatggtcaaa aacatttatg acagcctcct caaattgcag 503941 gattttcagc ttcacgatga ttttacgtta attgttttgc ggagaaaggt ttaacgtctg 504001 tcagacgagg gtataaagca actagtgatt tgaaggaaaa tttgaggtga tacgaatgaa 504061 tataaatgtt gatgtgaagc aaaacgagaa tgatatacaa gtaaacattg caggagaaat 504121 tgatgtatac tcagccccgg tgcttagaga gaagctcgtt cctctggcag aacaaggagc 504181 tgacttaaga atttgcctga aagatgtcag ctacatggac agtaccggat tgggcgtttt 504241 tgtagggacc tttaaaatgg tgaaaaaaca aggtggttcg ctgaaacttg aaaatctttc 504301 tgaacggctg atccgactgt ttgacattac aggcttgaag gacatcattg atatttctgc 504361 aaagtcagaa ggtggagtgc aatgaagaat aatgctgatt acatcgaaat gaaagtgccg 504421 gcccaacctg aatatgtggg aattataaga ctgacgctgt caggggtcgc aagcagaatg 504481 ggctatacgt acgatgaaat tgaagacttg aaaatcgcag tcagtgaggc gtgcacaaat 504541 gcggttcagc acgcttacaa agaagataaa aatggggaag tgtcaatacg attcggtgtg 504601 tttgaagacc gtttagaggt tattgtggcg gatgaaggag acagctttga ctttgatcaa 504661 aagcagcagg atctagggcc gtacacacct tcgcacacag ttgatcaatt atcagaagga 504721 gggctcggtc tatatttaat ggaaacgctc atggatgaag tcagagtgca aaaccactcc 504781 ggcgtcaccg tagcgatgac aaagtattta aatggggagc gagttgatca tgacacaacc 504841 atcaaaaact acgaaactaa ctaaagatga agtcgatcgg ctcataagcg attaccaaac 504901 aaagcaagat gaacaagcgc aggaaacgct tgtgcgggtg tatacaaatc tggttgacat 504961 gcttgcgaaa aaatactcaa aaggcaaaag cttccacgag gatctccgcc aggtcggcat 505021 gatcgggctg ctaggcgcga ttaagcgata cgatcctgtt gtcggcaaat cgtttgaagc 505081 ttttgcaatc ccgacaatca tcggtgaaat taaacgtttc ctcagagata aaacatggag 505141 cgttcatgtg ccgagacgaa ttaaagaact cggtccaaga atcaaaatgg cggttgatca 505201 gctgaccact gaaacacaaa gatcgccgaa agtcgaagag attgccgaat tcctcgatgt 505261 ttctgaagaa gaggttcttg aaacgatgga aatgggcaaa agctatcaag ccttatccgt 505321 tgaccacagc attgaagcgg attcggacgg aagcactgtc acgattcttg atatcgtcgg 505381 atcacaggag gacggatatg agcgggtcaa ccagcaattg atgctgcaaa gcgtgcttca 505441 tgtcctttca gaccgtgaga aacaaatcat agaccttacg tatattcaaa acaaaagcca 505501 aaaagaaact ggggacattc tcggtatatc tcaaatgcac gtctcgcgct tgcaacgcaa 505561 agctgtgaag aagctcagag aggccttgat tgaagatccc tcgatggagt taatgtaatg 505621 atccaggttg aagaaaacga gcatattcaa actctagtat atcaactgaa taaagaaggg 505681 aaatcgattt gcggtgacag tttttttatg aaagctgatg ataaggagtt aatttgcgcg 505741 gttgctgacg gactgggaag tggatcactt gctaacgaat cctctgcagc catcaaagac 505801 ttagtggaaa actatgcgag tgaagacgta gaaagcatta tcgaacgctg taatcaggcg 505861 atgaaaaaca aaagaggcgc tacagcatct atcctgaaaa tcaattttga gcaaaggcag 505921 tttacgtact gctctgtcgg aaatgtacgg tttattctgc attccccgtc tggtgaaagc 505981 ttttatcctc tgccgatttc gggctattta tcaggcaagc cgcaaaaata caaaacgcac 506041 accgccacct atgaaaaggg ttcaaagttc attatacata cagatggact caacgtacct 506101 gatatccgct cccatttgaa aaaaggccaa tcggtagaag aaatatcgaa ttcgctgaaa 506161 atgtatacga catcgagaaa agatgacctg acctatattc tcggacagct gtcctaaaaa 506221 accagaaaaa gaagctggac atccggcttc ttttttttgc ggttgactat taataagtgc 506281 gcttattata attaataagt gaacttatca ttctgggagc ttatgggatg tggaattatg 506341 aatacacagc gatagctgat gtggatgtgg gaaaacctgg aactgttatc aggaaacaga 506401 aacaatggat caatgggaga cgggtattgc atcagattct ttgaaaggac aatttcaaaa 506461 tggaacggaa ggaacattgc ttctgcaagg aaaaacaatt ctcttatggc ttgagcatgt 506521 ggagaaacat cgggcgtttt ctgtcatggt caacatgccc gcatagcaat gtaataatgg 506581 agttttttca cgtgcttcaa aagcaaaaag aagatttgtg tatcacatat ggaattgtat 506641 tagaaggcgc tgaagcaaaa aagtggggag aaatcattgg gactgaactg tctaaagaca 506701 tgccgacggc tgtcagcagg cttgtccatc tttacggagg agtgataaaa tgaacacaaa 506761 ttactggatc ggcgttgtgt cagagcaaca tgtattaaaa ggcgctgccg gcggttttgc 506821 acagctgtgc catggaaaaa aagccccgct cgccaaaatg aaagagggag attggctgat 506881 ttattattct ccgagagacg catatccaga cggcaaactg ctgcgaagct ttactgcgat 506941 cggcaaagta aaaagcggaa acatctatcc gtatcaaatg gctccgaatt ttattccata 507001 ccgattagat atagactatt atccatgcca taaaatcggt ttttacgaca ttaaatcaaa 507061 gcttgaattt gttcaggaaa ccaagcatct tggcttttta tttcgcagag gacactttga 507121 aataagcaaa aaagattttt tgacaatagc acaagcgatg ggagttaaca taagtggaat 507181 ggcactctaa atttagcggt ccgaacacaa gcccgggctt tttattatgg caggccacgc 507241 aaagttggca gcggaaagta ggaaaagcat tggctgagtt tgacctgacc cacgttcaat 507301 ttgttctgct gacctcgtgc aagtatatga ttgctcacgg agaaaccgtc acgcaaaaaa 507361 aacttgcaag cttcagccag accaatatca tgatggtttc ggaggttgtg cggacgcttg 507421 agaaaaaagg atttatcgaa agaagcaaaa atccccagga taaaagagag gtcctcctgt 507481 ctcttacaga aataggagga gaaaaagtaa cagcggcttt gccaattgtt gagaagattg 507541 atcaagcctt ctttgcagct gcgatgaaaa aagagaattt tctgagcggc ttacaggaac 507601 tattgaaaca tgagtaaaga tacgggcagc gccagctgtc tttttttatg tgtttttttc 507661 ggtttttgat acactagaga aagaacgaca aaattggagg ctttggttac atggaaacgt 507721 cagccctttt aaaacagcaa attgcgaaag aaataggttt atcacaaaaa cacgttgaaa 507781 gtgtcatccg cctgcttgag gacggcaata cagtcccgtt tattgcccgg tatcgaaaag 507841 agcagacggg ttcaatggat gaggttcaga ttcagacgat ttctgaacgc tggcaataca 507901 tacaaaacct gaatcagcga aaagaagaag tcatcaggct gattgcagag caggataaac 507961 tgacagataa tctaaaacgt aaaatcgagc aatcggtgaa gcttcaggaa gtggaagacc 508021 tttaccgccc ttataaacaa aaacgtaaaa caaaggcgac agtcgccaaa agcaaaggcc 508081 ttgagccgct tgccgactat atcctgacac ttccccaaga tgatcatctg gcagcaactg 508141 cagaccaata catcagcgaa gaaaaagaag tgttcacacg agaagaagcg attgaaggcg 508201 ccaagcacat tattgcggaa caaatctcag acgagccgac cttcagaaag tggattcgcc 508261 aggaaacctt caaaagagga accattaagt ctgcagccgg aaagtcggca gacaccgatg 508321 agaaaaatgt gtatgaaatg tattacgagt atgaagagcc aattgcaaaa gttgttccgc 508381 atagggtgct ggcaatgaac cgcggcgaaa aagaagacat tttaaaggta gcgatcgaac 508441 cgcctgcgga tcacattaag gcgtatttag aaaaacaaat catcaaaaat cgctcaacat 508501 ccgtaagaga gattttgcag gagacaattg aagacagcta taaaaggctg atccagccgg 508561 caatcgagcg tgaaatcagg aaagagctct cagaaaaagc tgatgaacag gcgattcata 508621 ttttctcaga gaacttgaga aagcttcttt tgcagccgcc gatgaaaggc aaaaccgttc 508681 tcggtgttga cccagccttt cgaactggct gtaagctcgc tgtgtcagat gagaccggaa 508741 aagtcttgaa aattgatgtg atctatccgc atgcgccagt caacaaaaca aaagaagccc 508801 atgaaaaagt gaaaaagatt cttgagcagt atcaagtcga gatggtggcg atcggaaacg 508861 gcacagcatc cagagaaaca gagcaattca tcgtcaatgt actcagagac atgccgcgca 508921 aaatttatta tgtgatcgtc aatgaagcgg gagcaagcgt ctattcggct tcagagcttg 508981 ccagagaaga attccctgac cttaaggttg aagagcgcag tgccgtatct attgctcgga 509041 gacttcaaga cccgctcgcg gagctcgtta agatcgatcc gaagtctgtt ggtgtcggac 509101 agtatcagca tgacgtcagc caaaaacgct taaatgaatc tctgcggttt gtcgtcgaaa 509161 ctgtcgtaaa ccaggttgga gtaaacgtca acacagcctc cgccgcgctg cttcaatatg 509221 tagctggatt atcgaagtct gtagcaggca acgttgtcaa aaaacgtgag gaaatcggaa 509281 agttttcaaa tcgaaaagaa ctgaaggaca tcccaaggtt aggtgcgaaa acctatgagc 509341 aatgtatcgg tttcttaaga gtgcaggaag ggacagagcc tttggataga acaggcatcc 509401 acccggaaag ctataaagaa acaaaagcac ttttgaaaaa actcggactt tcaacagaac 509461 atatcggcac ggcggaattg aaggacaaaa tcaatcagct ggcgctctct gaaacggcaa 509521 aagagctggg aatcggcgaa atcactctga aagacatttg tgaacagctg acaaggccgg 509581 aacgcgatcc acgcgataag gtgcctaagc ctttgctgaa aacagacgtc cttcagctgg 509641 aagatttgaa agagggaatg gaactgcagg gcaccgtgcg caatgtagtg gacttcggag 509701 cgtttgttga tatcggagtc aaacaagacg ggcttgtgca tatctcaaaa ttgagcaatc 509761 aattcgtcaa gcatcctctt gatgtcgtat ctgtcggcga tattgtgaca gtttgggttg 509821 acggcgtaga tgtacaaaaa ggcagagtat cgctgtctat ggtaaaataa aagcactgct 509881 tacgagcagt gttttttcct atagaaatac cagcattgat tcagcagttt aatttggtaa 509941 ttatcttttt caaggaacgc tttttgcatc tgctttttaa gccaatttgg cataggctca 510001 ttcctcctca gcttttatca taagagggac agtgattacc atattgtatg cgaacggtga 510061 attgtcccgt tcaatgtttt ttaagtgagg tgcaccatgg ataacaaaga gcttcaaaag 510121 ctgacagagg atatttctga aacatatttt aaaaagccgt tccgccatca ggcgcttttt 510181 aatgaccggc ttaaaaccac tggcggcagg tacctgttaa cctcccataa cattgaattg 510241 aacagaaaat atttgattga acacggcagg gaggaactga ttggcatcat caagcacgag 510301 ctctgccatt atcatcttca tcttgaagga aaagggtaca agcacagaga cagagatttt 510361 agaatgctat tgcagcaggt caacgcgccg aggttctgta caccccttaa gaaaaaagcg 510421 gaaaacaaaa aaacttatat gtatatctgt acgacctgcg gccaacagta tataaagaag 510481 cgcgccatga accctgacag atacagatgc ggaaaatgcc gcggaaaaat aaaaagaatt 510541 ttttcgtgaa aaaggttgac gaatatggca agcctatgtt acattataaa agtcgtcacg 510601 agagataaat aaaaacattt acctcttgac actgcaaatc aaggctgata taataagtct 510661 tgtctcatta ttccacagta gctcagtggt agagctatcg gctgttaacc gatcggtcgc 510721 aggttcgaat cctgcctgtg gagccatatt ggagaagtac tcaagtggct gaagaggcgc 510781 ccctgctaag ggtgtaggtc gcgtaagcgg cgcgagggtt caaatccctc cttctccgcc 510841 ataagatttc gatataagtt ctcaaccatc ggcccgttgg tcaagcggtt aagacaccgc 510901 cctttcacgg cggtaacacg ggttcgaatc ccgtacgggt cattccattt cgttgggcta 510961 tagccaagcg gtaaggcaac ggactttgac tccgtcatgc gttggttcga atccagctag 511021 cccagccatt tttatttttg aaatctaata gtaagagcca ttagctcagt tggtagagca 511081 tctgactttt aatcagaggg tcgaaggttc gagtccttca tggctcacca tttgtctttt 511141 tgcgggtgtg gcggaattgg cagacgcgct agacttagga tctagtgtct tacgacgtgg 511201 gggttcgagt cccttcaccc gcactttatt tacaaagtgc acgcaaatct gttttactag 511261 gttaagagcc tactaaacca gcacaacaca atttaatgat cacgcggtcg tggcggaatg 511321 gcagacgcgc taggttgagg gcctagtggg tgaataaccc gtggaggttc aagtcctctc 511381 ggccgcatca atgataccaa gggttttgac acccttggta tttttttgtg tttattttca 511441 aatgatttac tgcccacaaa ctgcccactt acctaaagta agtcatctaa tttatcagcc 511501 atttcctttt gcttgtttgg atataggtgt ccataaacat caattgttgt ttttacagaa 511561 ccatgtccta aacgctcttt aattgttatg taatcttctc cttggtgtat taatagtgca 511621 acgtgtgaat gtctaaaatc atgtaaacgt ataggagtaa gatcgctatc cttgcaaaag 511681 tatttaattt tccgactgaa aatatctttt cttgaaggtg tatctttata ttgaaagata 511741 taggtatcat gtgaatgtct aatacctaat tcattaaaca actcttcttg tgcttctttc 511801 caacgttcta gtagcttaag caatttttta ttgatgctaa ctcgccgaat cgaattttta 511861 gtttttggag tagtaacaac aaattgacca tcaagccagg tgcacgattt atgcacatct 511921 atttctaata agattttgtc aatatctttc cattgcaggg cgagcatttc accacatctt 511981 agtccagtta aaaaagcaac agtgtaaaag gttttaaaca ataattgatc ttgaggaatt 512041 aaactaataa attttttgaa ttcttctggt ctccaaaact tcattttctt tcttgttaaa 512101 ggtaatcgtt taacgttgtc acacggattt ctttttaaga tttcttcatg tacagctgta 512161 tcaaaaattt tgcttagact agtcattata ttattaaccg atttattgct tagacctgtt 512221 tccattaaat gttttctgaa atcagttatt tctctatgtg tgattttttg tatatcagat 512281 ttcaaaaagt aatcagatat atgtttgttt ataatgtact tctgattctg ataatagttt 512341 ggtttactat ctatttcaca acttgctaaa taaattgaaa ttagagtcgg aaagcttact 512401 gatctggact ttcttgctct ttcttcttga aattctcttc ttaattttgc ttctaattct 512461 aaagcctctt ttctggttga tgctactggt ctcgtcctaa ttctttctcc agtaatcggg 512521 tcaaatccaa agctaacgtc aacttgatat tgaccatttt caagtttttt tacagacatt 512581 ttatttctcc tttaaccaaa agcgcttatt tcgtgtgaat agattctgtt actaaatgag 512641 ccaatttgag aaagtttata atcagtaaca aatgatggta cgttgaagta tgctgctatt 512701 tgttctttgc taaaaccctg tatatatgga agggcttcat taagcatttt atctgtcagt 512761 attaattctg atgcaaatag gcttgcttga tgctcaagtt tatcttttag aactttagag 512821 caattcacaa ctttaaaagt gttcaatctt ttatggagaa agtaatgccc taattcatgg 512881 gcaattacaa attgttgatg ttggaggttc tcgttgatat ggattaaata ttgatctgtg 512941 gctttgtcat gttgtagtaa accgtttgct tgtccaagat catttttgag tatataaatt 513001 ttttggatgt cacaaatttc atagacatta tttgtaccat gtgtcttaat tactgattgc 513061 actttatgtt taattccttt gcttgtataa attgttatca ctctttcttc tttaattcgt 513121 caatgaattt aattccgttt tttaatgctt ttttaacaag gcgtgcagtt tcctcatcaa 513181 attcaccatc attcataaaa aggagtgtat cttcatcctt taattcctgt atggcttcat 513241 taattgtttt attgagtaaa tcagtttcgt ttttcttgct tacttcatcc tttcctaata 513301 aatagtctgt agatacgtta tataagttgc tcaattttaa gagtgtgtct gtatcaggat 513361 ctctgtaatc tctttcgtaa ttagacaagt tattgttacc gatattaagt ttctctgcgg 513421 cttctttctg agtgtaccca gctttttgtc gagcttcttt taatcgtttg cctaggctca 513481 tttttatcat ccatttcaca aagagttgat ttttataaaa ataataacaa cattttttgg 513541 agaattcatt aatttcacct ataagttaaa taaataattc taaattctcc ttttaggagt 513601 gtttgtttct tctttatgga gagtttaatt atcaatattt ccatatatgt tcaaaaaaat 513661 acactttaag gtgaattttg tgttgactta cacgaaaagg agttttataa taaagttaat 513721 tcacaaagag ttgagttaac gaggaggtga tattttgaaa ggagagtttt taactgcgag 513781 agatattcaa aaaattcttg gagttaaaca ggctaaatct tatgacatca ttagaacttt 513841 gaatgctcaa atgaaagaag aaggatatat ggtcattcaa ggtaaggtga gtagagctaa 513901 gtttgaagag tgttattgtt acaaaggccc aaaatctcaa acggggtgat ttttataaac 513961 attgatataa caaactcgtt tatgaaagaa gctgtccctt tagctagaca aatggaaggt 514021 gattggatag cacgaatgaa aattgctctg aattcagtca ttataaatca ttatttaaac 514081 cttcccttaa caattgaaaa tgttaatgaa ttactgcgaa aaggcgtttc atatcgcagg 514141 atatgtaagc attacggcat tggaagaaaa gacattgaaa agcttcggca atcatccgta 514201 gtgtgacgtt atataccact atagggagcc gttaagaatc ctttgaaagg agggatgcga 514261 tgaaaataag agtgaatgca acaatcatta ctgatgttga agctttaaag gctgataagg 514321 atttgaatca ttttaaagac tatgccactt gtgaaacatt cgttgttgat gctgataatc 514381 atttgaaggc taatgaagaa atatctgagt tgttaaaagg ctgggattgg tggtgtatct 514441 ggtcaactcg tccattgagt aaaaaggata accaagtgtt tactttgtat aacgatgatt 514501 tgtataactt atgtcgatag gagtgtttgt tccttgaaaa ctacatatag acaaaaaaag 514561 cgccttgacg aatgatcatc aagaacgccg gaaaataaaa actagacact tttattatac 514621 ggtattcttg ttgaaatgtc atgcgtgagt atttgagtga tgaacagcaa tcactttaaa 514681 tgctgtagca ggctagaata agcgtgcgga atagctgtag tcagcttgat ggctataatt 514741 agcctactag gttgccatga gggcgtaaag ccgttagcaa ctgataagcg ccaagatgga 514801 tacagaaccg gagcgaatca aaaacataaa atcgaaatta atgttctttt gtaaataaat 514861 tataaaaaaa tgaaatgggg atatgaaaaa tgaacttaaa ctttattgta ccggatatca 514921 atatgacttt tggagacatg aaattcatgg gacttaacag agaaaggtat gtttatgatc 514981 gtgaaaataa taagcgtact gacgtactgg aatctaggat ttataacatt gctagtgctg 515041 tccaaggtgg tcaaattgaa gtaactattc ctgagtatgc tggggcaaaa gaaattcctc 515101 cttttgcaga tattgagttg aaaaatccaa aaattagcgc tatggcgact agtcaaaggg 515161 attcgacgta tgccaatgtg atgtggaaac ttgaagctga tgatattgtt gttaaaggtg 515221 gctcttctgt gaaacctgcc gcggcaactg gcgggaatga aaagaaataa catgatgctc 515281 tcatatcggc aggcgggtga tgtatatgag tgatttctta aacaaaagat tttggaaata 515341 caggggcaaa cgaatccgcc cgtacatgag aaacaacgta aagttagcag gcgcaatcat 515401 ctttgtgcct gtttttttat tgtctatgtt ccttttttgg agagaacaac tcattcattt 515461 tgatctatct caagtgataa aaaattttga atggaatgtg cctttaatca ttaaaagcgt 515521 tttatgctct gtgctaattg ctgttggaag catagttgca tcttactttc ttttgtttga 515581 cagctataag aaaatccttc acaggcaaaa gattgctaaa atgattttct ctaacaagtt 515641 ttacgaaaaa gaaaacgtga aagtaagaaa aatcttttca aatgaaactg actcaaagga 515701 aaagatcaca tactttccta gaatgtatta ccaggtcaaa aacaaccaca tctatattcg 515761 tattgctatg gacatgagcc gttttcagaa tcgcttccta gacttaggaa aggatttgga 515821 aaacggctta ttttgtgact tggttgataa acaaatggaa gaaggttttg tatgctttaa 515881 gcttctttac gatgtcaaaa agaatcgtat ttccattgat gatgcagtag ctgagaatgg 515941 agtccttccg ttaatgaagc atatctcatg gcaatttgat aagttgccgc acatgcttat 516001 tgctggtggt acaggtggag ggaaaacata cttcatgcta acgatcatta aggcatgtgt 516061 tggactgggg gcagatgtaa gaatactaga ccctaaaaat gcagatttag cagacttgga 516121 agaagtactt ccgaaaaagg tctattccca aaagaacggt attcttatgt gcctgagaaa 516181 gtctgtagat ggcatgatgg aacgaatgga tgaaatgaag caaatgtcta actataagac 516241 aggtgaaaac tatgcttatt taggcttaaa acctgttttt atcttctttg atgaatatgt 516301 ggcatttatg gatttgttag atatgaaaga aagaaacgaa gccctttctt acatgaaaca 516361 gttggtcatg ttggggagac aggcggggta ttttctcgtt ttaggcgcac aacgtccaga 516421 tgcaaaatat ttagctgacg gtattcgtga tcagtttagc tttcgtgttt cattgggttt 516481 aatgtccgat acgggttacg gaatgatgtt tggcgatgtt gaaaaagcat atgtgaataa 516541 aaaggagaca gggcgaggat atgccaatgt gggcacaggt tcagtgttgg agttttacag 516601 ccctatcgtg ccgaaaggat atgattttat gtcatctatt aaaaatgcgc tggttggagt 516661 cgagggagcg caggcgacgg cagtcgccag cggcagcgta agcgaccaga cggccagcgg 516721 cgaaggagtg agcgaagcga atggatgagc taaaacaacc cccccacgct aacagggggg 516781 tagtaatcgt aaaagaaaaa aatgaagccg ttgaaagtcc tttggtatca atggttgact 516841 atattcgagt ctcttttaaa actcatgatg ttgacagaat tattgaagag gttcttcacc 516901 ttagcaaaga ctttatgact gagaaacaat ctggtttcta tggctacgtt ggcacgtatg 516961 aactggacta tatcaaagtc ttttattctg cgccggatga caacagaggt gttttgatag 517021 aaatgtccgg tcaaggttgc cgtcaatttg aatccttctt ggaatgccgg aagaaaacat 517081 ggtacgactt ctttcaagat tgcatgcaac aaggcggttc gttcactcgc tttgatttag 517141 ctattgatga taaaaagaca tacttttcta taccagaact gttaaagaaa gcccaaaagg 517201 gcgaatgtat ttcacgattt agaaaatctg atttcaatgg ctcctttgat ctatctgatg 517261 gcattacagg cgggacgaca atatatttcg gttctaaaaa gtcagaagcg tacctttgct 517321 tttatgagaa aaactatgaa caagcagaaa agtataacat tccgttagaa gaactaggcg 517381 attggaatcg ttatgaattg cggcttaaaa atgaacgtgc acaagtggcg atagatgctt 517441 tattgaaaac aaaggattta accttaatcg ctatgcagat cattaataac tatgtaaggt 517501 tcgttgatgc tgatgaaaac atcactagag agcattggaa aacgagcctt ttttggtctg 517561 attttatagg cgatgttggg agacttcctt tgtacgtcaa accacaaaaa gacttctatc 517621 agaaatcaag aaactggctt cgtaactctt gtgctcccac tatgaaaatg gtgcttgaag 517681 ctgatgaaca tttagggaaa accgatctgt cagatatgat tgcagaagct gaactggctg 517741 acaaacataa aaaaatgtta gatgtgtata tggctgatgt tgctgacatg gtcgtttaaa 517801 accaagctgc taaaccttaa taaacacagg tgatgcgatt aaacgtatgt gtcaacggta 517861 ccggaacgaa gtgaggataa ggagttgaca tattcagcgc tacccaaacc ctcttggcat 517921 tgaacaaaca accgtttgtt cctgcctacc ggcgagggag tcccccgatg attcggggga 517981 atagggggat agattaacag caatccaacg agctaccgtt ggtgggtttg ggtgaaaccc 518041 aagaactaac ttggagggat aagatgcata atgtcaatct gttgaatcag gctggactgg 518101 aaaatgcttt ggaatcagtt ggctgtttag atattgtaga agatttaata gaaaagatgc 518161 aggaatatgt tttgtatcat accgaaactg ccgaaagatt tgcgattgat atctttacag 518221 tagtaaacaa ctacactaaa aaggttcatg cgatatttaa tgttcttgaa aatgaagacg 518281 gtgagacaaa tgttaaaaat gtagaatttg aagtaatgca ttttacggag taaggacaat 518341 tttccttatg actttaaagg gggaacatca ggtgtttaat attaatctgt tgaatcaggc 518401 ccgacttgag agtgatttgg attcccttgg gtgtttggat attgctgagg aactgattga 518461 aaaaatgatg gaagatgttt tttacagtga tgtagctcaa agaatcattg ttcaaacact 518521 tgctgttata aataacgcca atgcaaaact tcaagctacg tttaacatct tagaagatga 518581 agatatggag acagacgaac gaagcgtgga gtttgaagga attagctact acgaataagg 518641 ggtgaaaatg tgcggtgtct gctgtagata aacgattcaa aagcttaggt tttaatgtgg 518701 gcattccctc tttagttttt gtgagaagtt taagcagaga ttgcatgttg gttgttgaag 518761 gagaacgagt aaaaggattt gctgagtatc gttacacatt ctataaaaca agatacttgc 518821 cagacggtcg aatgactagc ttaaaagttt atatggagaa tcaaagcata aaaagggtgt 518881 tacatcgtgt agcatccttt ttatctttct tggaaagaac gaaacaaatt gaacagaagg 518941 agtgtgaaaa agttgctcaa taaagaaatt ggctctgata agaaggaaga atcctttttt 519001 cggtctgctt ttcaaaaact gaaacgaatt gaaagaccgg aaaaagacaa acaaaaagta 519061 ccccgtgaca ggtcaaagct gatagccgtc acactatggt cttgtgtagg gagcttgcta 519121 tttatctgtc tgcttgctgt gcttctgtca attaatactc gctcccaact taatgacatg 519181 aaagacgaaa cgaataagcc aacaaatgac gataaacaaa aaatttcggt gactgctgcc 519241 gaaaactttc tgtcagggtt catcaatgaa tatatgaatg tgaagaacga tcaagaatct 519301 attgaaaaac gtatgcagag ccttgaaagc tatatggtta aacaggaaga taaccatttt 519361 gaagatgaag aacgcttcaa tgtggatggt ttaaaaggtg atcgagagtt aaagggttac 519421 agcttatata acgtgaaaga aggtgataaa aacagccttt ttcaatataa ggtcacatat 519481 gaaaatctat accctgtaga aaaggaagtt gaaaaagaag ttaaagacgg aaagaagaaa 519541 aagaaggtga aagaaaaggt taaaacaaac gagaaatacg aaaaacaaat gttgctgaat 519601 attccagtca caaataaagg tgattccttt gcggtgtctg ctgtccctta ttttacacag 519661 atttatgatc tgaaaggcga tattgctttt aagggtaaag aagaaactag agacgaatat 519721 gcaggcgaga aaaaagaatc tatcgaatca tttcttcaaa atttctttga gaaatacgct 519781 tctgaaaaga aagaagaaat ggtttatatg atgaaaaagc cggaagcatt ggaaggaaac 519841 ttgttatttg gggaagtgca gtcagtgaaa atcttcgaga cgaaaaaagg tttcgaggtt 519901 ttttgtgctg ttcgatttaa ggaaaaagaa aatgacattc cggtaaatga aaaattcagt 519961 ctagagatta cggaaaacag cggtcagttt tatgtaaata aactcaaaca tcaataggag 520021 gtttaaatat ggatttcatg aatttcttta ttcttggcgc agaccttcca acacttggag 520081 gggtaaaagg ttgggcatca gatgttgtta tccaattcat tacgattgtg gtcatgttca 520141 tagccgcaaa gaatctgatg aaattaaaaa tgggcggcat tatctttgtt tgctgtattg 520201 gcagtgcggt aacgtgggtt attaaacact ggtcagaatt ctccggctgg atcaatgcgc 520261 taatggaaaa attgtaaggg ggcatctgaa tggggcgtct ggtgttcaac taccggaagg 520321 caatgagaga gccgaaaaaa atccaacaat taaccgaaaa ttattcgtta ccctttgcag 520381 ttgagttaat accggctatt aactatttca tttttgttgg cttatgcttt ggattctggt 520441 acggcgtgag gatgattttc cctcacgctt ttgataacag ttacgtcatt gtgatttttg 520501 ggataccatt ttttttaacg atgcttgtaa cgaaaataaa gccggaaggc aaaaacatct 520561 atatatattt ctttgatttc gcaaagtatt acttcttcat caagcttcca caaaagaagt 520621 attgcaatga tcgaaagatt gatttaagta acgaaaaaca aattgagttt cgaaaacttg 520681 tgaaggtggt ggattattca aatgagacta aaaacgccta tgaaggcaat acacaagaat 520741 ttgctgttaa caagaacggg cgacgtgtgg gcgtactacc gaataaaaag caattcgatt 520801 cctatgcaaa ataaagaaaa agttgaatcg tataaaaaga agtggcagca tctttttgaa 520861 gaaattacat cttatgagga ttttcacttg atgatgtatc caagtgagta tgaattagaa 520921 aaacgattta aggatttaga aacagatatt gcggcagatg caatggatgt ggcacgttac 520981 tacaatgaag aaaccgtaag gctgttagaa cagcgattag gaaggctgac aaagtacgac 521041 ttcattttag gtgtaaaact gaaaagcagt cttgtaaata ttagtgtcga acttaaagac 521101 aatatactat cttttttcaa tacagcgact gatacagtcg tgaaaatgct cgggtgggaa 521161 caaaatgttt ccacctcttt ttttgaaaaa tatgaggaag tcgaagaaac actagcgaat 521221 atcatggctt ctgttcgcgg agaacggctt tcagaaacag aaatgacata cattaaccgt 521281 tatcactttg tacgtgggtt aaagcaccaa acgaatgaag aaagtgagat aaaggatgtt 521341 cgctctatta caaacacgat catagacccc actgacccat cagtattgca tttgcatagt 521401 gatcaagatg aaggctattc agcttttgtc gtgattgacg aatttcttca caatatgtcg 521461 gaaagtgatt tgttttatga agcacagtct cttcccttcc ctgttgaagt tcagatgaaa 521521 attcaaacgg aatcaaagtc cattaccaag cctgccctca acctcaaaag acagcaattg 521581 aaagaagaac aaaaagaaca acaaagcaca ggcgatcgaa gtgatgtttc cactgtcaca 521641 agtgccacaa tgataaggca tttacaagat gaaataaaga aagaagatgt gcatgtgatg 521701 aactggctgt cggtgatagt cgttcatgga aagacaaaaa aagaatgtgt gggaaaagca 521761 acgattgtca aaaggcattt aaaaggcgct ggcattactt gtcggcttcc ggtggctgat 521821 caattgaacc ttttttataa aatgcttcct ggtgaaaagt tagacataac cgataagaac 521881 tggattcaaa aaacaacgca agacggtgtg gctgaaagtc tgtttgctgt taactctgat 521941 attggttcga aaatcgggtt ctttctcggt tgggttgatc gtttccaaga gcacaccgac 522001 ttagaaagtg ccattatgtc cagccgtgat tttgtcttat tccacccttt cttagcgaat 522061 cagcagttaa aaggttcaaa gacacgttct cctcactgct taatcacagg agacacagga 522121 aacggcaagt catatctagc gaaattgatc tttaactata tcagcatgtt aaacatcaaa 522181 tctctgtata tagaccctaa aaaggaaatg agaaagtgga ttcaaagagt cttgaatgat 522241 gagtacatta gagagaactt tcccttatat attgcacatt tagagaaata caactatatc 522301 acgctagatc atgaaaacac gcacaactgg ggagcgcttg accctatctc cttcctccct 522361 cctatgaaag caaaagagct agttcaagtc atttttgaac aagtatatga ctttaaaggg 522421 aaggacgaca taaacacagc tttccttcgt gctacgtcag aagtgattga tgcgaaacaa 522481 aaaggtgaac aggtcggctc acttgatatt attcggaaga tgcagagcca tcccgaagaa 522541 gctgtacaaa aagctggtga ctatttaaat gaggtcgtgt cagattccat tttgaaactt 522601 tgtattcatg atggttcaaa tcctgcattg tcactagaaa agcgaattac cattttagaa 522661 gttgaaaata tggatttgcc ggatcatgct gagcgacttg aaaactacac gatatcacaa 522721 ctaaagtcta gtgcggtcat gtttgcacta ggtaagttct gcgagctatt cggcatgaat 522781 caagacgaac agactgttga atttatagat gaagcttgga tattcaccac gtcacaacaa 522841 ggaaaaaaag tagaaagaca aatgcgccgg attggtcgct catacaacaa tgcggaatac 522901 ttcatttctc aatccacaaa agacgcttta aaagaagagg attctggaaa ctttggcgtt 522961 gcctttgctt ttgacgaacc aaacgagcgt gaagaagtgt tgaaatggat gaacatggag 523021 gtcacaaaag ataacaaaaa aatgatggaa tccatgtttc aaggtcaatg cttatttaaa 523081 gattactatg gccgcacctc taaaatttcg attgaatgcc tattcgaaga atggcaaggt 523141 gctctgaaaa cagttgagaa aaaagccgtc gcatatgcgg aagaaaaata tttgtaaaaa 523201 ggggttgaat cgtacatgga aatagctttc ttaaactctc ttgttgtcac gagtccaggc 523261 ttttataaag ctgagaaaat cacattggac gaagttaaac aatggctgaa gcattatgat 523321 ggtcgataca aaagttttat cggacataaa tcaacggcac agtttctgca aaaattatta 523381 ggtatcagaa ttgagcaaaa tcgaaagact ttcagacata tgaaatatca aaaagcaatc 523441 tgtttctctc tgtatgaacg atatcctgaa aacgtgttgc taacgcaaag agacttagag 523501 aaagccagat accaatttta tttattaact cggttagatt aggaggtggt tgtaatgaaa 523561 aagaaaagaa ttttgattgt gtcggctatt gtgttgctgt ttttaactgt tgcttcagct 523621 gtaacggtat tttcggctga tggagataca acgacgcagc caaaagtcga aaaagctggc 523681 ggcgtggaat tgaaggtgaa aaggtttcca atctcacgct atcaagcgaa taatgaagca 523741 tctgacgatt taatcaaggg ggcgtttgtt gggctgacaa acgtcacttt ttcttttgcg 523801 ggaaacattg tccgtgtggt tgatacgggg atggatattt tgtataactt gcaaccgatt 523861 gacgagttcg caaattctat tacaaacgtc tctaaaacag tttataaaac actgaaaaag 523921 aatttcggtg aagctttatt tattttcacg tgcgcctatg ttgtctacct attctgtgtg 523981 agaggtagcg taaaagaagc aatgcggcgg agtattctat ttatttgtgt catggtgatc 524041 ggtgggcttt ggatgtcgaa cgctggttat tacatgaaag tattgaatgc cttgtctgta 524101 gaagctcaag gaaagctttt aactgcgggg aatggattgg ttggcattgt tcaagatgaa 524161 ggcaattttg cagacagttc agcgattgaa aaaggaaaag aaatggaagg cacagttgcg 524221 gttatgcgta atctttactt tgacattgct ttgatgaagc cttttttaat tgtgaatttt 524281 gatgaaacaa gcgaaaagaa aatcaatgag gaagatacag ataaaggcgg acttaatcgt 524341 atagataaac tgctttctta taagctttca gaggatggag aaaaagataa aaaagattat 524401 ataaaagaga ctgaaattga tgattataaa aatgaatcta tgacttctgg aaatgtgttt 524461 aatcagctgg gagagtcttt tatcgctgtg gtcgcttcta ttgtcattgg gataccattt 524521 ttagcattag cgttctttaa tttcttgctt caagttgtcg ctttagtgat agttttcttt 524581 gtgccatttg ctttcatctt agcgtatgtt cctcaattag cttattcggg atttgttacg 524641 cttggacgct tggggagtgt ttacctactg aaagcaatgt taggggttat cgttctgttt 524701 gtgtacgtga cttgttttat tgttgacaag ttaataccgc caaatggttt tggaatgtat 524761 cttttaaatg ttgctgtcct tgcttcaatc ttgtggattg gttttcacaa gagggatgcc 524821 attatcaagt ttgtgactgc tggaaaagtt gtttcagttg ataataatat gatggaaaac 524881 atgagacaaa acattgttca gcctgcttgg gaacaagcga agaaaatagg tggagtatgg 524941 ggtaacggag gcggcgtatt tactgacttt acaaagcatt ttgggggaag aaaagacggt 525001 tcgaatgctg atggcgtaac tggtgctcca agtggtggcg gtaattcacc gagtgggact 525061 gctatgggat atgataatac tcatgctatt tcaagaaccc cgcaaaaaga aacagctaac 525121 ggaatagcta atcataacag tcgaagctta aaacgcaatc ctcaaactct atcgaaagaa 525181 caagaaaagc aaaaacaaaa agaagccttt gcaaatgcaa aagaaaataa acagcaatcc 525241 catttagcca gattgagaaa agacggaata aactctccta tgttgaaaga tgctttgaat 525301 gaagggaatg aggatttatc caaacgagca cctatcttgc aggataaaaa agatgaatca 525361 gcacgaacag atcaaaaaga atatgtggaa cagcttctta aacagcccaa taaccagcaa 525421 caaactgacg atgcatcatt acagcatgaa gaagaatcta cttctaatcg tgcgcctgtc 525481 ttacaagaga atgaaaaaga tacagaacgt actgatcaga aagcgtatat ttatgacgaa 525541 caaaatcaga atcttgaaac agatcagcaa caagattttg aagtccagaa agatgattct 525601 gtttccaata gtgagcctgt agcacaagag aaaacagcag aaatcaaacg atcagatcaa 525661 aaagtcatga tgaatcaacc tgaaccgcag ctcggttttg aaagtcctca atctacaaaa 525721 gtagaaaatc aacctattgc caataacgaa cgtaaaatca gaccatctga acccgcaaaa 525781 gttcattcag atggtattcg tgttgatgaa aaacaggctg ttgctcctgc tgaaaataag 525841 actgtatcaa gagaaaaaca gccttcatca caaacaatta aacggactga acaaagcgtt 525901 aattcatttg accaagtgtc tttgaatgaa attgcaagac gctcttcatc aaaagtagaa 525961 gatcgactga gaagggatga aagaacaaga tgataagtaa aaaggtagtt cttcctttgg 526021 tattctcggc tccttttatc ttcttttttg ttttatgtat cgtagtggtt atgacgattt 526081 caagagaaaa tcaagtcggg gacgatttta taggcggcgg ggatggcgaa tatgaaacag 526141 ttggaattgc gccggaagtg gaacgattta gagcagtatt tgagaaatat gcccgtcaag 526201 aaggcgtttt tgaccaagtg aatattatta tggcgctcac catgcaagaa agtggtgggc 526261 gttctttaga tatcatgcaa agttccgaaa gtatcggctt acctcccaac tccataactg 526321 acccagaacg ttcaattgaa gtcggcatta aacattttaa gaaggttttt aaacaggctg 526381 gcggtgatgt tcgtttaacc ttacaggcat acaactttgg ttctggattt atagactatg 526441 tcaaaaagaa tggcgggaaa tacacaaaga aattagcact tgatttcagc cgattgcaag 526501 cttttaaaat gggctggaaa agctacggtg acccaagtta tgttgaccat gtcatgaggt 526561 atgtgaaagg ctctgataaa aatgtgaagc ctgtgaaagg ctctatggat ttctatgaaa 526621 cggtcatgaa agaagctttg aaatatgaag ggcaaccgta tgcctgggga ggttcaaacc 526681 cggaaactgg atttgattgt tctggccttg ttcagtggtc ttttgcgaaa gctggaatca 526741 ctcttcctag aacagcacaa gaacaacatg gggcaaccaa gaaaataagt gaaaaagaag 526801 cgactgcggg tgacttagtg ttctttggcg gcacatacga aggaaaagcc attactcacg 526861 tcggcatcta tgtaggcaat ggcagaatgt ttaattcaaa tgacagtgga atccaatatt 526921 ctgatctgaa atcaggttac tggagagatc accttgtatc ttttggacgc attaaataac 526981 taggagtgaa aatatgaaaa cacatattgc atgggcttca gcttgtttat tattagtcat 527041 gttaactgga tttttcacga ttggacagca aacgtataag attgaaaagt taaaagataa 527101 aaatgaagtt ttgagcgaaa aaattaagga attgaaccat atagaatcaa caagtagcgc 527161 ttcggaaaat aaggcatttt ttgaagcgtt ttttaattac tccgacatag atatacgata 527221 tgaaacagtt aagaagcaca caactggaaa agggtttgat tatgcattcc cttctcgttc 527281 tgatcaaaag cacacagtca gcgtgcaaag tgaattacta tcactagaga gttattcaaa 527341 gccgttagat gagtctcatg aattgttttt aaacattgtt gaagtcgcca caactgcaaa 527401 ttcagtcact acgaatcaag tgttaattgt acaaacgact atgaaaaaag aaaaggatgg 527461 ttggttagtc gataatgtgc aggttaaggg aaatggataa aaggtggaaa agatcaattt 527521 gtttgtttat actaaatatt gaaaaaggag gtaatgttta ttttgaaaaa cctttttatt 527581 ttccttagtt tgatgatgat gtttgtttta actgcatgtg gtggaagcaa gtatgatgat 527641 gcgattgatg atgtaattag ccaatataaa gagcataaag gaaatgacac agagataaat 527701 attaaaagag agaatgcgat tgttagagtc tatgaagggg gcaaatatat tcagtttgca 527761 ttttatatgc cggataactc ttcacgtgaa ttaacaacat ttaagtatta tgaaaaattt 527821 ggagataaat atgaaaagat gactgatatg ccggggaatg gggaaaatga tcgtctgggg 527881 ttatcaaaga aaacaccaga ctatgaagaa gtaaaaggag aagagacaga gttagaggag 527941 taaaccgtgt gtttactcct cttttagttt tattgacatt ggtaaaacag agatagggta 528001 agaacttagc taattaagaa tgaaaattat aaggtttata agttggaaac taaatcaaat 528061 atgtcttcta agaatagatt tatgggtaaa agttgttttt acactattgg tgctactagc 528121 agtggcattt aagttatttt aatttcgtat taaatttagc ctttatcctt tcccattttt 528181 tatcttctaa tgtgagatca tacatacgga gtattttttc ttttaaatta aataagtcta 528241 ttggttcctc caaggagaat gcttttttat ttttatcaat tactcctttt atttcgccct 528301 taaaaccagg gaggatgaaa gtagagcagt tattgctatt cacccaagta gcccccattt 528361 cattaaggca gtatacgcta tcatagtaat tatcggataa catataaaag acatatgcac 528421 ccttaaaaag atgttttttt agatattcga aaatatcttc atctccagga ataccatgat 528481 aaggtgaaga agtgtatatt atatcttcag aagacactcc tatatcctct agtaattcaa 528541 cgaaagcatt acatacaatt ttgtcttttg aggagtggct aataaatatt tttttctcta 528601 attctctatt ttgatcactt gaaaagtgag ttatgctgct tttttcagtc tcatctacta 528661 caggcaattc atctaaaaat ttttttattt tattttctgt ttcatgatgt tcaaactcat 528721 taaaaacaaa ttcattttta tatatttcat tgcggtttcg tgcataccaa gtcttaagtt 528781 gttctagtga ataacgaatt aactcaatat catttgattc aagagatgtt cgaaattgat 528841 caataatatt tgtgagtaca ggctcgcgag agtaatctag aagtactcct ataattccat 528901 tagcctcaaa ttttaatttt tttaatgtgt ccattagatt tcctccgacc taatttaatc 528961 cattgtttgt aaacatttca tatctaatta tataacatag actcctattc taactactta 529021 ttttaaagca gtctggattg tttgggtaat tcataaaaaa ataaaagaaa gaaggaggaa 529081 tagagttttt cttttttttg tttgcaatgt tactgtcaag tcgcaaaaga attgctatga 529141 ccgaaaaaaa accgcaaagg aatagatata aggtaccttt ttgcaattca tctttgtaaa 529201 ataaaggtta ttctgacata atacaattaa tgtaaaaatt cgcacaattt tatgtaagga 529261 tgggggaatt ttcttgcggg gtgttttctt agataaagat aaaattccgt acgacttagt 529321 cacgaaaaag ttaaatgaat ggtatacatc aataaaaaat gatcaagttg agcaagccga 529381 gattataaaa acagaagtag agaaagaatt gttaaacatg gaagaaaatc aagatgccct 529441 gttatattat caactattag aatttagaca tgagataatg ctgagttata tgaaatctaa 529501 ggaaatagaa gatctcaata atgcttatga gactataaaa gaaattgaga agcaagggca 529561 attaactggc atgttggaat actattttta cttttttaag ggtatgtacg agtttaggcg 529621 taaagaatta atttcagcga taagtgctta tcgaatagct gaatcaaagt tgtcagaagt 529681 tgaggatgaa atagagaaag cagagttttt tttcaaagtg tcctatgtat attattatat 529741 gaaacaaaca tacttctcca tgaattatgc aaatcgtgca ctcaaaatat ttagagagta 529801 tgaagaatat gctgtccaga ctgtgcgttg tcaatttatt gtagcaggaa acttgatcga 529861 ttcattggaa tatgaaagag ccttggaaca atttttgaag tctttggaaa tttccaagga 529921 aagtaacata gagcatttaa ttgcaatgtc acatatgaat attgggattt gttatgatga 529981 attgaaagaa tataagaagg cttcacaaca tttaatttta gcgttagaaa tttttgaaaa 530041 atcaaaacat agtttcttaa caaagacttt attcactcta acctatgtag aagcaaaaca 530101 acaaaattat aatgttgctt tgatatactt taggaaaggg cgatttattg ccgataaaag 530161 tgatgataag gaatactcag cgaaattcaa aatattagag ggattatttt tttctgatgg 530221 tgagactcaa ttaataaaga atgcattttc atatctggct tcgagaaaaa tgtttgctga 530281 tgttgaaaat ttttcgattg aagtcgctga ttattttcat gaacaaggaa atttaatgct 530341 ctctaatgaa tattatcgta tgagtattga agcaagacga aaaattaaaa aaggggagat 530401 tattgatgaa aatcagccgg attctattgg cagcagtgat tttaagtagt gtattttcaa 530461 taacttattt gcaaagtgat cataatactg aaattaaagt tgctgcagat cgggtagggg 530521 catagcttag ataattggaa aagaggaaaa aagcttaatc ttttttcgaa ggttaagctt 530581 tttcttttat ttataaaaag tgaactaact atcagaaaga aattatatta aattttattt 530641 ttttgtttaa aaagtagatt atataaaggc aagctaggtg ggggaaaata tgtttaaaaa 530701 agaaaaagtc acagaataca tttggactat actaatacca acaatcatca cttttatcat 530761 tagttgggtt gggtcttatt acaatggtac ttcgacagtt agtattggac aacctacaaa 530821 agtttccggt cagtatatca cgccaataaa tataagtccc tatcatgata ttaaggaatt 530881 aagaataact tttccgcaaa aactagatgt aaaacaaatt agttcaaatg agcctataaa 530941 tgtaaaatca gataagaaca atataggagt tgaaagtaat tccacttttg agattgcgaa 531001 aatcgttgaa aataatagcg ttcagttgct aattacaaca caaaaaaagt taaacgataa 531061 ggaaattaga attgataaaa atggaaataa catttctgta aattatgaat ctcagattgt 531121 taatcctgca aaaaaacaat taatcaatct tataattacg tcatctattt attttataat 531181 gcttaatata ctagcattga ttatgaacaa aagatgggat aagtattatg caaaaatgaa 531241 aaatgaaatc aaagaatttg aggataatgc aaaagatctt gataaaaaat caaagaagaa 531301 aagcgaggaa ttatcggagc tgcgaaagac cttgaaccaa gcgtttgagg aaactgatag 531361 gataaaatat catgagaaga aaaaacaaat cctcctctta gctaagttaa acgattataa 531421 aaaagaacta accttttgga gaaatacaat aagaaaagtt ctttatgaac ttcctgatgg 531481 agataaaaaa gcagataaac taatagggac agttacatca tctttaaaaa cgtacggtac 531541 agtcgaaaaa aacgagcatg attatgaaag tttaaaagta gcagctgcct tactaaatga 531601 ttctgataag agatcgtaat gtactggatt ttaataaact attagaaaga agattagctg 531661 caaacatcag aacgaccaaa caatggtggt atgtttatag agtttagttg ttgaaaaggg 531721 cgaactatga gtttgctgcc catttactgc ccagaataaa taacaaatca tgaaaatcag 531781 tgtaaataaa ataacttaat gctataaata aaggcttttg taaataaaga tatgatttta 531841 ctaggttgag ggcctagtgg gtgaataacc cgtggaggtt caagtcctct cggccgcatc 531901 tcaataatac caagggttta accacctttg gtattatttt tttgtgtgga aaatacggct 531961 atgggagaag acttgctcac caaaactcac cagttactta aagtaagtca tccaaacggt 532021 cggcggttcc ttctgtttat taggaaaaag atatccgttc attgtaaaag aaacgaacca 532081 tgtcctattc gttcaaaaaa actaaagggt gatacatatt atacatgatt aatatgtatc 532141 acccttttct ttcttgttca acaatcgcgc ttgaggagaa cataagctaa tacaactgac 532201 tcgatttcta aagttgctcc attctttttt taaacaactc atccacaacc tgttttaaaa 532261 tctcgtacga ctgaatttcc ttgctcaatt cgtaaatatt agataacaca attaattcat 532321 ctgcgtgata catttgttgg aaatcaatta gttcgcgacg aattgtttct cgatcaccca 532381 tgattgtata ccccagtcga ctgtggagaa tttctaattc aaactgtgat aacgattcta 532441 ggaagttttc agtgggtgga ataagcttac ttaaattatt tgtataaata tcaatataca 532501 cctgcaaatg acttgcagaa ataaaagatg cctcgtctat agattctgct gcaatcacat 532561 taatgcaagc gatcacataa ggttcttgta aataagaaga cggttggaaa ttttctcgat 532621 aaatagagag cgcttcttcc atcgaatggg gtgaaaattg agcgccaaat gcatagggta 532681 aaccaagctt tgcagcaatt tccgctgaat ccgttgagga tcctaacaca aaaacaggca 532741 catgcgttcc aatacccgga taagcgcgaa cctcaccctg tacactctta tccccgacaa 532801 aacgcaaaat atcatttact tctctttcaa agaaaaacac tccattatgg ttggaacgac 532861 gaatcacatc ggccgttttt tgatccgttc cgggtgcgcg tcctaatgcc aaatctacac 532921 gatttggata taatgtttca agtgttccaa attgctccgc tacgattaat ggggaatgat 532981 ttggcaacat aataccccct gaacctacgc gaatgtcttt tgtatttgct aatatatgtt 533041 gtacaattga tacggttgct gcacttgcat aagcgtcgtg attatgatgc tctgcaaacc 533101 aaatccgttt atagcccata ttatctacag ctttagctaa tgacactgca gaatcaatcc 533161 cttgtttcat tgtttctcct tgtcttaatg gagcaactga taaaacagat atatcaaatt 533221 ttttcataat ttcacctcta aaataatgaa cttatacaag atcaatggaa aaaacatttt 533281 gaaaaattgt ttcatattaa atggtgtcca ttcctctttg atttgcatgc aaataaatat 533341 atactttctc aaacgatcaa tacataggca aaataaagtt atttcacaat ttcactttac 533401 ttttaaagtt ttaagcaaac ataaaaaaat gttcagtgaa caaaatatgt aaaatacatc 533461 ttatttttca gaaaggatac aagaaaatga ttgatgaaat agataaaaaa atacttgatg 533521 agctgtctaa aaatagtcgc cttacaatga aaaaattagg ggaaaaagta catctcactg 533581 caccagcaac cgcatcaaga gtagtaaagt taatagacaa tggcataata aaaggatgta 533641 gtatcgaagt gaatcaagtg aaattaggct tctctataca tgcttttctt aatatttata 533701 tcgaaaaaat ccatcatcaa ccctatttag cttttataga aacacaagat aactatgtaa 533761 taaacaatta taaagttagt ggagacggtt gctatttgct tgaatgtaaa tttccttcaa 533821 acgaggtatt agatcaattt ttaaatgact taaataaaca tgcaaactat aaagtgtcga 533881 ttgttattgg taaatagtta actttataaa acggagatgt gcggtcatat aacatgatat 533941 atatgctcta aaaaagccct aggttggata tggaatttac caagctgggg cctttttata 534001 cattataata acaagcgcat tattcatcag acattaatga agtattataa tgctttttta 534061 cttccttaat agacaaataa agctgatagt ttccatactt caataaatca ttcagaaggt 534121 gatttaaaac ttcttgtgaa tgaaccgtta ccttcagaag ataacatgca tctcccgaaa 534181 cacgatgagc ttcgctaatt tcattacgag tagcaataaa tttcaataaa tcatcatgca 534241 tatatgcatt catgaaaaag aagacaaagg ctgtaaaaga aaaccccatc ttcaattcat 534301 caaccacaat cgaatatgct ttaatgatac cgttatcctc catttttttg atgcgattgc 534361 ctaccgcttg tcctgtcata tgaatttttt caccgatttc tttccattgt atccgagcat 534421 ttttatttaa taattggaga atttgaaaat caattgaatc aatttgcata gtaactcctt 534481 tcacagtgaa aaagttttac aaaatagtat ttcatgagac catcgaaaat tcaatggaaa 534541 ttatatatcc ttatacagta taaaaatttt aagaggtgaa aaaatgacaa cagctttatt 534601 agtgattgat attcaaaatg attactttcc aaatgggaag atggctttaa caaacccaga 534661 gaaagcagca caaaatgcgg ctaaactact ttcacacttt agaaacacag gcgcacctgt 534721 ctttcatgta cagcatatca cagaaggtaa catcgctcat tttttccatc caaatacaga 534781 aggtgtcgaa attcatgagt cagtacgtcc attagagaaa gagacagtca ttgtaaaaca 534841 tatgccgaat agctttttca atacagattt aaatggaaag ctacaagaag aaggggttaa 534901 agaattagtt gtttgcggta tgatgtccca tatgtgtatt gatgcaacag ttcgttctgc 534961 agttgaacat ggttatgtat gccaagtggt agaagatgct tgcgcaacaa caacattgca 535021 aattgaagat aaaatcgttc ctgctgagca tgtccattac gcatttatgg ccgcattaaa 535081 tggtgtctat gcaacagtaa aaaccacaga ggcattttta aaataaaaga atttcctgcg 535141 cgaacataac gtctttcttt tcacaagaaa gatgattcaa caacttaaaa aaggatgttc 535201 agaaaaatac ttctggacat cctttattca ttatctttta ttgtttttca gtatcattat 535261 tcccatctga taaaagatca agatgtcctg tttttgatcc atagtaagac catatacagg 535321 gattgttttt gccataaata tagatattga tgaaggttta cataaagcac ctaattgctt 535381 gatttacttt aatgttagat ccctcaataa ctccattctc ttctaatttc tctactctag 535441 ctgtagctgc tgggcatgtt aaatgtactc tctcccagat ctttcattga attcggctat 535501 tatacataat ttctctataa ttttttatct gtttgatcta tttgaacgtt aattcctttc 535561 gaaaataaag tcaaagagtt aaaacacttt tttttatcta tgtattcgaa cactgctgat 535621 attatacact taactctgtc gatctaagac aaataaaaaa agaaagtgag ttgtaaatat 535681 gaatattaca caaattcgaa atgcaacaat tgttgtaaaa tacgcaaata aaaaattttt 535741 gatagatcct atgttagcag agaaaggtac gtacgctact ttccctgaaa cgatcagaca 535801 agatttattt aatcctttgg tgagtttgcc aacatcaatt gataacattc tggatggcgt 535861 agatgcggta attgttactc atctacacct agatcacttt gatgatgtgg caaaaaacgt 535921 attgccaaaa aacatcaaaa tgtttgttca aaatgaagca gatgcaaaag aagtaaaagc 535981 aagtggtttc aaaaatgtag aagtgctaca tcaagacact gtttttgaag ggatccaatt 536041 agtaaaaaca aaaggtgaac atggcagagg ggaagagtta ttaaacttaa tgggtgatgt 536101 ttgtggatta gtattcaagc acccaagtga aaaagtttta tatgtagctg gggatacagt 536161 ttggtatgat gctatcgaag acgagattca tacacatcaa ccagaaatca ttgtggttaa 536221 tggtggagac aatcaaagat tagatttagg ttcactcatc atgggaaaag aagacatcta 536281 tgaagttcac aaggctgctc ctcatgctaa gattatatct gttcatatgg aagctgttaa 536341 ccattggaca ctatctagag aagaattaaa aaactttagt aaagaaaaag gattctcaag 536401 taatatttta gtgccagaag atggcgagtc ttacacattt taatatgaac accgacaaat 536461 aaatagaaga agctcataat tataaaaact aatcatgagc ttcttctaat aatgaatatt 536521 ttaaatttta aatatatcga aaatcctaaa tatacggaat aacaaaaatg gaatgttcca 536581 atgatgacaa aaaaacttga aaagcaacaa agatgtgtcg ttaggaggta gaattcatgg 536641 taatgacaaa aaaagataca aatatatcaa cacagcagcc tctttggtta caaggttata 536701 ttgattcacc agaaaaacaa aaccaacttt ataaaaaaac attaaaaatc ttgatttttt 536761 cacaaatatt tgggggagca ggacttggag ctgggataac agttggggcg cttcttgcac 536821 aagatatgat aggatcggaa aatgtagcag gaattccaac tgccctcttt acttttggat 536881 ctgccgtagc tgccctgctt ataggagcat cctcacaacg ttttggtcgc agagctggac 536941 ttgcaggtgg tttccttata ggcggattag gtgctatagg tgtgataatc gcggctttaa 537001 ttaacagcgt tgccctatta tttgtttctc ttcttattta tggagcaggt atggcttcta 537061 atcttcaagt tcggtatgct gggacagacc ttgcaaatga gaaacaacgg gcaactgctg 537121 caagtatggc cttagtttct actactttag gagctgtagt aggtcctaac ttagttaata 537181 caatggggga atttgcagat tcaattggtg ttcccaattt agctggtccg tttattatgt 537241 caggagcagc ttttataatt gctggaatta ttctcttaat ttttcttcgt ccagatccgc 537301 tgtttgtatc aacagctatt gcgaatgctg agaaaaaaga cgataaagta caaataggag 537361 gaagtctaaa aaatcctgct atagacaaaa aaggaataat ggtaggagct gtcattatga 537421 ttttagctca actaatcatg acagctatta tgacaatgac accggttcac atgggtcatc 537481 acggtcatgg tttaagcgaa gtgggattag ttataggact ccatattgca gcgatgtatc 537541 ttccttcacc attgactggt ttattagtag ataagtttgg tcgcacaact atggctattg 537601 cttcaggtgc cacacttctt gccgctgggt tggtggcagc tattgcaccg gcagactcat 537661 tatcattgct aatcctagca ctagtattac taggggtagg ttggaacttt ggtttactaa 537721 cgggaactgc ccttattata gattcaacac atccatctct acgtgcaaaa acacagggaa 537781 cattcgatgt tttattagca ctatcaggag cagcaggtgg agccttgtca ggaatggttg 537841 ttgcacattc tagttataca atactatcaa tttctggagc cgttttatca ttgttactca 537901 ttccagtagt tatttggtat tttagaagga ttcaggaaaa agcataagct tatataactg 537961 tctttgaaga acctaagtag acattacttt accggaacct cctttttcta tttattatag 538021 taaggagttg acatggcatt agtggcatgt gtataactac acaattattt gggattcaga 538081 gagcatgtaa tgaacggaag agataattat ttatcacttt tattattgta cggtgttctt 538141 gtggcattaa gttcagtcaa ttttggtcta actgttttct ttttgttttc atcacctctc 538201 catattatta acaaacacga aaaggatttt aatgaaaata aaatgattag cgtatgtatc 538261 tctaattttc aaaatgaatg aatagtcctt tttaagattt acacacttat tctccaagga 538321 aaaatgactc aatttttcga ttttttatgt aaatcaaaaa agaatcatgt tagagtaggt 538381 gtgctgaaaa taattcaaaa aattattttg cgatatgatt aaagtaatat tgccagagag 538441 tttcaattgg acaaaattgt aagtgtttaa tacactgggg ctgcaatcaa atatgcacct 538501 ggaatcaatt gctaaacggg ggagtttata tgaacaacaa gaaaaatatc tttgatattg 538561 ttatgtacat tattttcggt gtgttaagtc tttttctagt tgcaaaaact gattatggca 538621 ctggagtttt agtgtttgtt gcaattttat acctcgctgt tattgcttat aaaattaagc 538681 aagtatttag taattcagat tcttaaggtg taacacaagg aggatttcaa ttgagaaaga 538741 aaagagttat tacttgtgtt atggctgcat cattgacttt aggctcactt ttacctgcag 538801 gttacgcttc tgcaaaggag gactctaaga caaccccttc ttacgaagaa ctagctctac 538861 attacaaaat gaaaagtgaa aagatttcat cgaacgggaa attagttgaa attgagtatg 538921 tgagtggaaa tgaaactcac aaagttcaga tgaacggaaa taatcatact gtaaaagtcg 538981 atggcataga acaaaaaggt ttaaactttg agtatgatga aaatgttgct aaaagaacaa 539041 attatgaaaa caataatttg aaatcaaatg aattcacaac acaggctgca aaacctaaaa 539101 agggatacca ttatgtgggg actttatctg ggcatacaaa agcagctaaa aatgcgttat 539161 cagttacaat gtcattagtc ggtattgtcc ctggcttggg atgggggagt aaggctgcca 539221 ctattttatt ctcttattgg gcaaaagaac aaatccctga tgcgtattat aaatatgatt 539281 tatacgaaaa aggagcaatg actgatagtt ggtatcagta tgctacagtt caattttttg 539341 aagataaagc tcataaaaag aaaatgggca aaccttggac aagtactcct gcaaaagtag 539401 atttacctaa tagctaattt taaaatcact ttgtctttat aaaggacaaa gtgatttttt 539461 gttatacaga agtaaaatcc ctcgtctgag gaatcttgga aaaaacttgg ttcaattttg 539521 atataacatg tttttttctt gctaatttag tttttctatg tatcgctaca cattctaaat 539581 aataagatat tagccggacg gttgatgcca agctcaaaag tttatatgga agtcaaagca 539641 taaaaaaggg tgttacaacg tgtagtcttc tttttatttt gccaacgtaa caagtgtgaa 539701 agtaatgatt tgtaggatca gttaagaaag gtttaagatt agatattgaa aaattttata 539761 tattttcaat aaaatactgg tactataata aatgtataca gattgtatgg agatgtaatt 539821 aattaaaaag gagtttttaa ttgcgttgga gtaaatggtt caatgttttt tgtatagtag 539881 cattgggatc aatatatggt tataaattat ttactaacca agaagtcagt actactcgtt 539941 taataatagc ttctgtaatt gtgttgtgga atattgttgg actttttagc aaagaatcag 540001 taaaacaagc acagcaagca aattaaaagt cataaagttg ggaaagaagg atgttactta 540061 tgtagtatcc ttctttatta ttccttgaaa aatgaaacaa attggagatt acagcttata 540121 taatcaattg aagtcgttga ttattttcat gaacaggaga tttaatgctt tctgatgaaa 540181 tattatcgta tgaatgttgc aagaggaaac gttactcaaa gattacaggg atgtgatgaa 540241 cactcctctt tatcgcactc acctgacccc aaattgttgg ggaagggcag gtacggaaga 540301 tagagtattt tttcttcgta acaaatcgaa aaggttggat aataaaaaac ttataatcta 540361 aggcggtata tagttgtgaa aaaggcgtta tttcttatat tagaccagta tgcagattgg 540421 gaaggtgttt acttagcatc tgcattaaat caaagagaag attggtcggt tcacactgtt 540481 tctttagacc ctattgtaag ctcaataggt ggttttaaaa catctgtcga ttacataata 540541 gggttagaac ctgcaaattt taatttgcta gttatgattg gcggggattc ctggagtaat 540601 gacaataaaa aactattaca ttttgtaaaa actgcatttc aaaaaaacat tccaatagca 540661 gcgatatgcg gtgcagtgga ttttttggcg aagaatggtt tgctgaataa tcatagccat 540721 acaggtaatt ttgtttactt atggaaagat tacaaacaat ataaaccgat tagcagtttt 540781 gtagagaaac aagcagtaag agataaaaat ttggttactg ctaatggaac tgcccctatt 540841 gaatttacta atttaatttt agagatgatt gattttgata ctcctgagaa catagagaaa 540901 atgatgtata tgaatcgtta tggtttttat catttttgtg ataaatatgg aaatccattt 540961 gttgattaat ttgctggaaa tgattttccc gaataggggg ctttgcgatt gagttgaatt 541021 tcctaataaa gcaaagaaag atgatttgag gtcaagttta acaaataatg ccatcaatat 541081 taatttgcag ttatttccga ttcctgatat aataaagaag aattattttt gttcggtgta 541141 aaggatagta tgaagattga cttttcgtct tgatgatact ttgggcaagg atagtatata 541201 ctgtgtggtt acacactagg aggcaacaaa aatggaacaa ggtacagtta aatggtttaa 541261 tgcagaaaaa ggttttggct ttatcgaacg cgaaaatgga gacgatgtat tcgtacactt 541321 ttctgcaatc caaagtgacg gattcaaatc tttagacgaa ggtcaaaaag tatcgtttga 541381 cgttgagcaa ggtgctcgtg gagctcaagc tgctaacgtt caaaaagctt aatcttcaat 541441 cgtttataca aacaggctct ttatataggg cctgtttttt tatgtctata tcatactcaa 541501 taaaaaaccc tactcaacgt tcgagtaggg agatgctaca aggtaataga aaaagattta 541561 aaacttcaaa ggtttgttta cagtataaca tactggattg acaatatgcg gaatgtatat 541621 aaattattta atgttttgtt caaatataga taactgactc tttttttcac taacctgttc 541681 gttcatttaa gtaagattag atgaattata aaaatggttt catctaaatg ttatcaactc 541741 gcatatctct tttatgagaa gaagataaac aattattatt caatgttgca gtggatataa 541801 gaaattctta aaaataatga ggagatcgat tgtttttttc tcctggaaat aatcacttag 541861 agatacctaa aacaatgaaa gccctacctc tcttccatcc ttacggctcc ttgtccgtgc 541921 cagtgtgaat caggatacta aaaaaagtga ctattttatt gagttttttg gtaaaacttc 541981 aatcttcgca gaagaaatgt aaataataaa aatggattag aatgtaggaa taacaaaaga 542041 ggtcgttaat gttctaaaca taagttggag aagatttgct tttcatcata atattccgaa 542101 atatcttttg ggatgtatct aaccaaaact ttttatttgt ttttcagtga ttcctttaat 542161 tacttccagt tcactaatca aaaattcata tgcattatcc agcatttttt tttcgcttgc 542221 attaagtgct ttttctttct tcatacgcat taaatcacgt acaacttcag caccttcttg 542281 tatttcacct gtttttattt tgtccgtgtt tattttgtac ctttgcttcc atggcagtaa 542341 cctatcggat tctccatgct gaaaaatgtg cataatgtgt tttaatgcaa gtatatcggt 542401 aactggtcgt atattcgaac tcaatatttt actcgttgga atcataactg tcatattact 542461 gattgacatt cttatgacat aatactgttg tttttcctct aagaattctt tttcttctat 542521 ggcttcaatt atacctgctc cgtgcattgg ataaacaatg ttatcgccaa tttgaaacat 542581 atcatccacc tccatatatg gtatccttct taagattacc atatatggag gtgtaatatc 542641 aaaattttaa taataacatg atcgaatttt tgatgtcaat aacttttttg aaaaaacaga 542701 tcaagcaaaa acaataggga acgtgtcgga tttccaatca ggaaaaggtc aattgatccg 542761 tgtgagcagt ttttcattgg ctcaatgaca ttacagaaat gatttgagta gataagaaag 542821 aacgatattc gtgaaatgtc agctaaaaat atttaaagca catgattaag ttctaatttc 542881 tttaccgatt tgatatggat aacggccgac ttacttaatg atgcattttc acttatcttg 542941 caagcagaaa aaggtttgtt gataaacatt tagccaccaa attggcatta ttatcaggga 543001 aattgacaac cttcaaatgg gtattgaggc gagaagaaaa ataaagaaag gagagattat 543061 aaatgaagac cagaacataa agaagtaaag gggaaagaac aaggttaatt gaaaagcaaa 543121 ctatataaaa tagtttgctt ttttttgtta tgacttcact tctttttctt tctctttaat 543181 gactaataaa acaccgctca gaattaaaaa cgaacctatc caaaatgtcc cgcctatttg 543241 ttctccaagc agaatccatc cgagtaaggt tccaaccaga ggctgaaaaa agaaaaagag 543301 gcctccactt gaggcattta ataattgtaa gccgtggttc cacaataaaa atgcacaagc 543361 tgttgaaaca attcccaaat acaaaaggcc acctagaatt ttagggtcaa gcagtagtgg 543421 cgtaaaaatc gtgctagggg agtaccatta acagggactc catttattaa tagaataaac 543481 tttatgaatt catttttttg tatgataatg gcgtcatatt catcgcttgt tgaaatttac 543541 ttatgaaata actggtactg ttaaatccaa cttgataaga cacttctgtc acattggatt 543601 cagggtgttg cagtaataat aagctttttt gaattctata atccattaca taacgtaatg 543661 gcgtcttatt cagcattcgt ttaaaataac ggcagcattc agaacggctc agttggccag 543721 cttttgcaat gtcctctaat gtgatttttt caacataatg gagatggatc cagtttaaca 543781 tttgtttcat tcgatgactt tttatcattt cagattgatc gtactctaat tgaaaaccat 543841 taacgaccag gtttttccac attaacgtta attgcatcgt aatgtcaatc tcatagagcg 543901 atgtcttttg ttgaatcaat tgatttattt ttttaacagc atctagaata ttttttgccc 543961 actgttgatt tccagccaaa aataaatagg gcaaattggt tgaaaacata tagggctgaa 544021 catagcttga atacagttcc tgagataaaa cgaaatgggg tgacacattc aagcaaatat 544081 acgtacaatc cgagccttcc ttttcttcgg ccatgtgcag gtagccgcta ttgataaata 544141 atccatcccc ttcgtgaacc tctatttttt cttcatttat ttgaaagaga gctatccctt 544201 ttagtatcaa aacaaattgg atttcatcat gccaatgaag cggaatatag ccatttatat 544261 tttgattgat cgttgtcttg tagcaggcaa ctggcaattc taccgttcgg tgctctgtta 544321 attcttttaa attttgatcg atcacaaaat tcttcattct gacttcacac ctcaatatat 544381 ttatattttt tcattcaatt tgagtatttt ttatcatgtt ttgcatttat tataacacta 544441 ttattatatt tattagtgag gagtcatgta tgaatacttc caatagaaga atgggattgt 544501 tctatgttat cacaggggcg acatgttggg ggattggagg cacagtagcc aaaaaacttt 544561 ttcaagaata tcaaattgat gtcaattggc ttgtaacgac acgcttgctt acggctggaa 544621 tgttactttt aatgctgcaa ctgttcagaa aggatcgttc ccaggttatt gaggtgtgga 544681 aacacaaagc gtcggctggc cagcttctaa tttttggcct attgggaatg ctagctgtgc 544741 agtacacata tatggcatcc attcaacatg ggaatgctgc cgttgctacg ttattgcaat 544801 atttatcccc agtaatcgtc attatctaca cgctgttgcg aaaacaaacg gttcttacca 544861 aacaagatat cataactgtt gtacttgctt tagtgggttg cttttttttg ttaacaaatg 544921 gttcaatgtc tcaactttca gtgccggcag ctgcagtagt atggggagtt ttatcaggat 544981 tcgcggcagc tttttatact ttgtatgccg ttggtttatt aaataaattt gattctcttg 545041 tcgttgtagg ttgggctatg attattggcg gttttgcatt gggttttatc catccgccat 545101 ggcaactgga ttttcaacga ttaactgctg aggcgtatgc atatatctta ttcgtgatat 545161 tatttggaac aatgattgcg ttctggttct tcataaaaag cttggaaagc ctctctccaa 545221 aagaaacaag cctactaggc agtctagagc ctctatcagc tgttgtaaca actgtcgttt 545281 ggttaaaagc gccatttggt tcttttcaat ggattggtgc tatttgtatt atagggataa 545341 ctttaatatt ggctttacat aaagagcctt ctatggagag tgaaaaatcg atattaaaga 545401 ttaggaatca tgcaaatcgg gatatatagg ggcttttttt gcttacatga ccggtccggc 545461 aatgaaaaac actggtggag tttgagccct ctcggcagta tcaaaaatac caagggtttt 545521 gacgccctag gtattttttc ttcaagaacc ttcaattttt cttctctgat tgaaaaacgt 545581 attacttttt tgtgattggt atccaaattt cacttttaaa agatggtgat gttacatcct 545641 tatgctcgtt ccacaatatt tctggacctt ctatttgttc gtaatttgac gatggaaacc 545701 attcggaata aatgcgtccc catacttctt gcagtgtatc cggaaatggc ccgattgatt 545761 cgaatacagc ccatgttgag gcaggaactt caagccgtga gaagttatct ggacaccgtt 545821 tcgttgtggc tgcgccaata tagtgatcga gctctccgtt ttcctctgtc cgaccttcag 545881 aaaaattcgt ggatgcacta atgaggcctg atggtgctac attagatagc tcttttagtt 545941 tatttattgc tttttcatct aaactttccc acatagatgc aatttccgga ttaattcctt 546001 tgaaaataat aggaactctt tttttaatgc caacgatgcg aaatgcctct ttttcttcaa 546061 tacggtagtt catttcattt cctcctttaa ttgttagctg gaaggtcatt cgtggataag 546121 ctttaaggga atggccatta aatctggctt ttgatgggtt tatgccatgt aaattttgga 546181 atgcccgtgc aaaagaatct ggtgagttat aaccgtactt tattgcaata tcaatcactt 546241 ttacattgct gtctttcagt tcaaaagctg caagagtaag acgtctgcga cgaatatatt 546301 ccgataatga aatacctgca aggaaggaaa acatcctttt aaaatgatat tcagagcaga 546361 aagcaagctt tgctgcctct tgaaaatcaa tatcattagt gaggttttct tcaatatact 546421 ttaacgccct attcatactt ttaagcaaat ccatttattt ggcctccttt aaccaaagaa 546481 taacaggagt gaaatgtatt tatccgacat tctgtgcaca gttttgcagg atgacttata 546541 tgaaataaag taagtgattc acttgtattt gtacaggttt tattgaagca tgctgttcat 546601 aaaaaggcat caataaaaga aagttataat tgtcttataa acggcacatt catataattg 546661 agtgaaaaag gatgcgtatc atgcctatca attcttttga aaattatccg atgagctgga 546721 agccatcgat tgataaagct gaaaagccta tttataaagc acttgcaggg caattggaac 546781 aggatatttt aaacggagtt ttattacctg gaacaaaact tcctccacag cgagaattgg 546841 ccgattatct agatttaaat gtgagtacga tttcaaaagc atttaaagtg tgtgagttaa 546901 aagggctgct gagtgcgact gtagggagcg gcacatttgt atcgtatgat gcgttgtcga 546961 atgcgtattt acttgaggat actaagccga cacatttaat tgaaatggga gcaatacttc 547021 cagatcacgc ttcatatgag cccttgttat accaactgaa aaacatggtt catgaggagg 547081 attatgaaaa atggtttagc tatggccggg caggtgaaag cctttggcaa aaagatgcag 547141 ctgtaaagct catccaaaga ggcggatttg aaacatccgt tgatcacatt ttatttgcaa 547201 atggagggca aaatgcgatt gcagcgacat tggcgagtct ttgtaagcct ggagatcgca 547261 tcggagttga ccatcatacg taccctggat taaaaactgt tgcatcattg cttagtgtgc 547321 aaatcgtacc gataaaatca gaaaacgatg aaatgagtcc ggagtcactt gaatatgcgt 547381 gtaaaaacga aaatattaaa ggtttgtatt taatcccgga ttatcataat ccgacgactt 547441 cctttatgtc tgttgagaat cgaagaatgg ttgcagacat tgtaaagaaa tataatctgt 547501 ttgttattga ggatgcatcg taccatcttc tcaacaaaaa tccgcttccg gcactcgcct 547561 cattcgcacc gcaacaggtt attcatattg caagtttatc aaaatcgtta gcgccaggcc 547621 tgcgtttggc ttatgtagca gtgccgagac aatataagga gccaatatca aaggcgcttt 547681 ataatttaaa tataactgtt tccccgctat tagctgaact tactgctcgc acgattgtat 547741 caaatcaatt tgaagtctta attgagagtc atcgtgaaca aaccattcgc agaaatcaac 547801 tcgtaaaccg atatgttgcg ggatatacat gtttaggtgt tgaaacaggc atttttcgtt 547861 ggttgttgtt accgggtaaa atgtctggtg ccgaatttga agaattggct gctcgacttg 547921 gcgtgcaagt gtatgcggct gaacgctttg tagtgggaaa tagttgtcct gaaagggctg 547981 taagggtttc tgtctgtgca ccaaaaacac ttgaagagct tgaacaagga ttaatgatcc 548041 tgagacgttt gctagacgat cttacctaat attgtttgcc atacaattat gacattgtat 548101 ggcttttttg tgcgtgttat gatgatccac atctagaggg aggtttatac aaaattggct 548161 tttagaaagg aaggtcagat gatgttagac aaggacagcg taaaagcaat agatgttcaa 548221 actgcttcat tacagagcta catcagttca ccagaaaaac aaaaatcgtt atacaagcgt 548281 acactattcg ttgtgagtat ctcacaaatt tttggcggtg cggggctggc ggcaggagtg 548341 actgtcggtg cgcttattgc acagcaaatg cttggcactg atgcgtttgc tggtttgcct 548401 tctgctttat ttactttagg gtcagcagga tctgcattaa ttgttggaag actttctcaa 548461 cgttatggcc gtcgaacagg tctttcagct ggctttatga ttggcggact tggagcaata 548521 ggcgttatta tggcagcaat cataaatagt attttcttgt tatttatttc gttgcttatt 548581 tacggtgcag gtacagccac taatttacag gcccgttatg caggtacaga cttagcaaat 548641 cataagcagc gagcgactgc tgttagtata accatggttt ttactacatt tggcgcagtg 548701 gcaggtccaa gcttagtgaa tgtgatgggg gatttcgctc tttctattgg tgttccatca 548761 cttgctggcc ctttcatttt agccgcagca gcatatatgt tagcaggtgt ggtccttttc 548821 attatgcttc gtccagatcc attagttata gcaagaacaa tagaagcggc aaatgaagag 548881 cctggtgata aaggacattt ggcggcaact gagcatacag aaaacaaaaa agggataatc 548941 gttggggcaa cggttatggt tcttacccaa atagtaatgg tagctattat gacaatgaca 549001 ccggttcata tgagacatca tgggcatgac ttgggtgcag tcggtcttgt tattggtttt 549061 catataggtg ctatgtatct cccttcactt gttacaggtg ttcttgtaga taggttggga 549121 cgtaccgcaa tggctatttc ctctggaaca acgttgcttt tggcaggtgt aatagcagca 549181 tttgctccgg gagaatctat gattcttctc gtcattgctc tttctttact gggattaggg 549241 tggaattttg gtttgataag cgggactgcc cttattgtag attcaactga tactgccaca 549301 cgagctaaaa cgcaggggac agtggatgtt ctgattgcgt tgtcaggagc tgctggcgga 549361 gcattatctg gaatgattgt ggcaggttca agttacctcg cattatcact tattggaggg 549421 attttgtcct tattactcat tccggtggtg gtatggtcta ggggccgcta aagggtagga 549481 ttgtttaatt tacattaatt tgttatattg ttagataaag tatattgcag catctaatat 549541 tctaacgaac tatagttgct ccattaaatc tattataaag atttgaccag gattccttat 549601 agctgtgtca ctcactgcat attctttaat tgaatcacat aaaatggtta tcggatttga 549661 aaaaggcagg attactcgct ttaggtaaag gagtcataac gttgttaaaa aggttttctc 549721 ttgttattgt tacactaatg atgtctatcg ttgttgtttt agcggctgct aaagagtcgc 549781 ctggagatca tgtcatctca tttgatgaac ctattatctt gatgatctca attggaatcg 549841 ttgtattttt attgatccct ccattagtca tgtccttttt tggcaatttg gttgtaagaa 549901 taatatctgg tgtataccaa tgttttatcg ttttcacttt tctggggctc attccaattg 549961 gatttcttat tcccaatggc tttttgacaa ttctagtttc tattgcagga actttagtca 550021 gtatagctag tgttgccgta accttatgca ttggcaagaa taaaaaagat atataatcat 550081 cgaattgtta ttttttcaga ttgtcagtga aataattata caaaaagaga aggcttgtgg 550141 gccttctttt tttgttgttg catcatcccc actttgagct taatctattg aataataaga 550201 gaaggaacct atagaagaat aaaataaata ccgagatgtc aaaaataaaa ctggacttca 550261 ttattgtgaa ttcacgtaaa tgtaaaaaga ttggaaagag gggaattcct tcatgacaaa 550321 tagcagaaca aatccgaagg ttgatgaatt tttaagtaaa gcgaaaaagt ggaaggaaga 550381 atttgagaag ttgagaacca tcattcttga ctgtgagctg actgaagatt ttaagtggat 550441 gcatccttgt tacacatatc ataataaaaa tattgtttta atacatgggt ttaaagaata 550501 ttgcgcgctt ctgttccaca aaggcgtctt attacaggat acagatggaa ttctcattca 550561 acaaacggag aatgtacagg cggcgcgcca gattcggttt acaaatgttc aggaaataaa 550621 tgagctagaa aacattttga aagcctatat tcacgaagcc attgaagttg aaaaagccgg 550681 tttgaaagtg gatgttaaca aaaatattga attgaacatt cctgaagaac ttcaaaataa 550741 attcgatgaa atccctgcat tgaaaattgc ttttgaagct ttgaccccgg gacggcaaag 550801 agcgtacact ctttattttt ctcaagccaa acaatccaaa acccgagaat cgagagtcga 550861 aaaatatgtg caaaaaattc tcgatggaaa gggattaaag gattaggcac gccaaggttc 550921 aggctaaagg aatagcatca tagcgtaata agatcatttc tatagaagaa aaacaagcat 550981 agtaagatgc ttgttttttc ttaggacaac attcacttac tgctgaaatg cttctaacat 551041 tgtatgccac tagacagcgt tataaaatat taatgcaaca cctagaaatc tatccaatga 551101 aatagctcaa tggtatggct cattacattt agaatgccta ggagaactaa tagaaccgga 551161 agatttttag caagttacta cactccaaac tttgtttttg tattaatata ccttattaac 551221 cattgttttt agtcaggtgc agacaaacga atactgatta atgaatcatc atgatatcaa 551281 tgagccgctt gattttttca tcgtcgcctg tatcaacgta cactgttttt ctgtttttta 551341 tgatactctc agtcacttcc cgcatgacgc ctttttctat atcatcagcg gaatcccagc 551401 gtaaaggcac attatataca tgaattgtgc catccccatt gccatgataa gtgactgatc 551461 catccactaa acgagaacct gccaactggg tcacattttc tggatagctg gcacttgtat 551521 catcattagg attaattggc tcgccagccg caatatgtcg aacatttaat tcatctatct 551581 cttgattagg tccaagttga agccaaactc tggcatattc aattttttcc gaagagtatg 551641 ctgccaatac attgtcttct ttgcttttct cttctgctga agaggtatca tttgcagctt 551701 ttgttgcgga ttcttctgat tctgttattg gctccgcttc atccttgcgt attttggtgc 551761 tctcttcagg ctcagtgtgt ttttcgtcag tttgcacagc agaagcttga tttgaaggtt 551821 gttgtgcttc tccatcctta ctgtccgtac atccagcaag caaaatcata agcagcaggg 551881 cagtattgca ataacatatc tttctgcgtt tcttcatttt ttcattcctc tctattaatt 551941 caggtcagct tcatatataa gtttatgtat ctaaatatta ccatggaata gataggatga 552001 tattgaaaac tgtttaagaa gaggaaacga tcttgaatag catcgcgaaa acctaagaat 552061 cttaagaagt tttgcccctt tttcttcagg tattgaatgt aaagtgggat ataaatgcaa 552121 acaaaaacga aatgccttat ccacctcgtg tcatggcaga aaaagtgggg gatttattag 552181 agcggatttg ataatggcgg caggtaaatg ggtgttgact tatatgtcta agcgggagac 552241 tcaagtctgc tcgatcgcat acaaaatacc aagggccagc aacccttggt atttttatac 552301 cttcatgcat ttttgaagtt tatgcttaaa ggtctgcctt actttgcaaa tcgccgagct 552361 gctgcaacgc acatgataac ggcgatattc actgctacga gtgcccagcc cactttctcg 552421 tgcagaatca ctgaggcaag cagcagtcca aaaaaaggct ggagaagctg gagctgccca 552481 accgctgcaa ttcccccttg ggcaagacct cgataccaga acacgaagcc aatcagcatg 552541 ctgaataagg atacatatgc aagactgagc agtgcgggaa cgccgatcgc cgaccatgag 552601 tccggcgtaa aaaagaacga caatggcagc ataagaggaa gcgacagaac gagtgcccat 552661 gagatcacct gccaattccc cagacgccgt gaaagtttgg ccccttctgc ataaccaaga 552721 ccgcatacga caatagaagc cagcatgtac gcgtcgccaa gcggggatga acctcccccc 552781 tgaatgaggg cgaaacctgc tactaacaag ctgccggcag ctgagaaaat ccagaagacg 552841 gggcgagggc gttcaccccc gcgcagtacg ccgaagactg ccgttgcgag tggaagaagt 552901 ccaatgaaga caatggcgtg tgcggatgtg acatgctgaa gcgctaaagc tgtcagcaac 552961 gggaaaccaa tcactacgcc gaacgctacc actaacaatg aaatgagatc tcttttggca 553021 ggatgctgct gccggaagat gagaaggaga cctcccgcca gtacaccagc tatcgcagca 553081 cggcaaactg tgagaaataa cggatcgaag tctgacacag ccaaacgggt cgcaggcagc 553141 gagccgctga aaatgagtac gcctataaaa ccatttatcc agccatttgt tgttttgttc 553201 attataatca ctccacatat ctttcttgtt cattgtctgt attttcttaa caaaaccagc 553261 agctaaggat tacaatgact ataaactgga attggccttt tataaacagc cagttttcat 553321 aaaaaaatgc ataccagtta ggagaacaac gcgcaaatgg atatcacgcc ttttttgaat 553381 agaactctgg atattccgct ttatcagcag ctttatcggt attttaaaga aaatatgcat 553441 cggggccgta ttcaaaaagg aatgaagctt ccttcaaaaa gactcctggc gaatcagctt 553501 tccatcagcc aaacgactgt agaacgtgcc tatgaacagc tcgctgctga aggttatatt 553561 gtgagcaagc caagaagcgg gtggtttgct gattatcatg attctgattt tgcttatgat 553621 agaatgccaa gcacaacacc cattcaacaa gaagcagaag aaaataaaca atggattgat 553681 tttcattatg ggaatgtaga ttcttcttac ttcccttttt ccgcatggcg aaaaagcatg 553741 gtcaatagct tagaccaata tggacacgag ctttatcggc cgggacatgt tttaggagag 553801 tttgagctga gaacactcat tgcagagtac ctgtatcaat ctcggggggt tcattgcggc 553861 cctgaacaag tgattatagg tgccgggaac cctattctgc tgcaaatctt gtgccaagtt 553921 tttgagccga atatttctat agggtatgag gatcctggtt atccaagagc acgcaagatt 553981 tttgaagcca accgcatgaa tattgttcct ataccagtcg atgatgaggg aatctgtata 554041 cagaagatca aagaacagca gccaaacctt gtatatgtca caccttccca tcaatttacg 554101 ctgggaacca taatgacaat aaacagaaga attcagctgc tcaaatgggc ggccgaaaat 554161 caatccttta tcatagagga tgattatgac ggggaattta ggtacacagg acagccggtt 554221 ccttctctgc aagggcttga tcagcataac cgtgtcattt atatgggcac tttttctaag 554281 tctcttttgc cctcgctgcg tatcagctat atgattcttc cttcgcctct tttaaaaaag 554341 ggtcatgaaa tcacgtcctt atataagcag acagtgtcct gccacagtca gctaacccta 554401 gctgaattta taaaaaatgg agagtggcaa aaacacatca acagaatgag aaaactttac 554461 cgcaaaaaaa gagccattgt attagaggca gtgcaaaggg aattaggaga gcatgtcaga 554521 atccgcggag aaaactctgg gcttcgtatc ttacttgacg tttatttgcc atttggtgaa 554581 aaagagttaa ttgagaaggc gaaaaaacat ggagtaaaaa tttatcctgt ttctctttct 554641 tatcaacatc atcctcctac aaaaacggtc tcgctcgggt ttgcaggggt ttctgaatcc 554701 gacataagag aaggcataaa aaaactgaag gctgcctgga agatatgagg gagctttcag 554761 tttagcaaaa cggccaagtg acgactaagt gttgagagct gttcaatatt ttttaagtat 554821 atgatgagtg cctgcagtcc aggccacgat acgtctgttt agcgaaaaac agaatttttt 554881 atttgctcct cacagtgcta aaataaacaa aatagacaat tgaaaaaata gaggtgtaag 554941 aatgaagtta gatgagttta caattggcca ggtcttcaaa acgaaatcat taaaagtatc 555001 aaaagatgat attatgcggt ttgcgggtga atttgaccct cagtatatgc atgtagatga 555061 agaaaaagcg agtaaaggca gatttaatgg aattatcgct tccggcatac aaacactggc 555121 catatctttt aaactttgga ttgaagaagg tttctatgga gacgatatta tagccggaac 555181 agagatgaat catatgacat tcataaaacc cgtatatccg gatgatgaat tgtttacaat 555241 tgttgaggtt cttgataagc agccaaagag aaatgaattg ggaatactca cagtattgct 555301 atctacttat aatcaaaaag aagtaaaagt gtttgaaggt gagttatctg tattgatcaa 555361 acgataactc agaaagcccg cttttcgcgg gctcgattga agcagatggg tgaaagatgt 555421 tagcgggttt cctttgaaaa ataagaggtt aaaacatcat aaacaatagg caaagaagta 555481 aatccctcat cttctagaaa atgacctccg tgctgaactt catataacgc agcatcaatt 555541 tgttgtgcca gatccttgct gaatgaaaaa ggcacaattt ggtcgtcctt agaagcaatg 555601 acagcacggt gcttcgcgga ctcgatgatt ttttgatgat caaacgatcc ctgtgtaaat 555661 tcatctaaca tctgtaaagt gggcaatgat ttggcaaagc cggaaacaag tatgattccg 555721 ccaagctgtt ttcgtaattg aagatgttcc aaaaatctca aaatggcggg gcaacctaag 555781 ctgtgcgcaa ccaaatacgt attttcatgt aaagtgtgct gatataaaga gagtgtatcc 555841 agccaatcct caagtcttgg ctggagcgga ttaggcatgt ttaaaatgtc tgcttggacc 555901 ccatctgcga gcagacgttt tttcagccaa gggaaccaat gatttgttga ggaggctctg 555961 tagccatgaa tgatatagac ttgttttgtc attatttcct cctaagaaat attttcattc 556021 agtataaaat tcctctcatt gggaaacaag tacgcacttt tttgtaagta gctttacata 556081 tgaggccctc cttgtgccat tccccactta cacatctcat ctatgagggg atacaaagat 556141 cgccctctgt cagataacga atactctact ttcagtgggg tgtgagaaac ctcagaccga 556201 tgaataaggc cgtcagtttg caattcctta agctgtgcgc ttaacatttt atgggtgatg 556261 aagggcatag cccttttcag ctcgccgtat ctcatcgttt tttcacaccc taactcatag 556321 agaattctca ttttccattt gccccctata agagataagg tgtattcaaa tggggcttgt 556381 ttactgcggc acaggctatt cattgtaatc aaacctcctt ttttaagtat catatcagaa 556441 taaattagga ttttcggtgt tgaagtttga gggcgattca cgatctgaag tgaaaggggc 556501 cgcttgctca acaggcggca cggtacatga atgttctaag tcaaagaggg ttaccttact 556561 gttagttact ttatttaaaa aaacgcatgt ttttagctga aaatatctat tatggtatat 556621 ttaaatataa agaaatattt gagaaatgag gaatggtatg aatacaccca aaaaacataa 556681 gaaatttaaa gcgaaaatga ttctccaaat catcatggtt atcattggag gaatcatagc 556741 ggcatatgga ctagaaacag tgctcattcc aaacagtgta tctgatggag gggtgacggg 556801 tcttagcatc gttggttcac agctattcaa cttgccgctg gggattttga ttgctgtgat 556861 caacattcca tttgtctggt taggatataa gcaaattggg aaaagctttg cattattatc 556921 aattatcgga atcgtatcgc ttgccgcggg gacaagcttt ttccaccaca cacccgctat 556981 catagaagga gataccctgt taattaccgt tgtcggcggg attatccttg gattcggaat 557041 ggggctggcg ctgcgtaatg gcggcgcatt agatggaatt gacatgcttg ctgtgctgct 557101 atcccgaaaa ctgccattcg gaacgagcga tctcattcta ttcttaaacc tatttgtgtt 557161 tatttttgtt tccacagtat ttggcttaca aggggcattg ctttcagtca ttgcttacta 557221 cattgcatcc aaagtgattc atgttgtgga ggaaggctta agcggctcta aaacctttca 557281 aattattaca acccaacctg aattaatggt agagacaata cgtgatcaat taggccgaag 557341 cgccacatat aaagaagctt acgggggttt ttcccacgag aaatttaaag aaatcacatg 557401 tgtcatcaac cgtttagaag aaaccaaact aaaggaaatt attaatgata ttgataaaac 557461 tgcctttgtt accgtgtatg atgtagctga agtgaagggc agcaatttta gaaatcttaa 557521 tcatcactaa aaaatagaat gaccttttta accgtaactg acatgccgcg ggtaatttaa 557581 tcaaaaacac ttttttgagg cttgtgggtg aataaccggt gaaggtctga atcacagaaa 557641 taccaagggc gtcaaaaccc ttggtatttt ttctggttat tagattttat cttcagcttt 557701 acgtgctgct tcgagcttat caatcctgtc tttatatttt tctccccagt ccttcatgtg 557761 caggataaca ggttctaatg ttcttccaaa ctcagttaaa gagtattcga cttttggagg 557821 gacctgttta taaacctcgc ggtgaatcac gccatcccgt tccaattctc ttaattgtag 557881 cgtgagcata cgctgggtaa tttttgggta tagttttcga aactcattaa acctcttttt 557941 accgtcaatg agatgataaa gaagaatgcc tttccactta cctccgatga tatctaatgt 558001 tgtctccacc ggacatcctt caaagtcatc agaagaataa tcaatgccga gtttacgatt 558061 tctcaagctg ttcactccta atagtatact ttttgatact atatacattc aatgtgcgta 558121 ctttttatat tttaatatac atcatataat gatgtcacat ctaaggaatg aaaggaatgg 558181 atcatatgaa aacactcgta ctcgttgtac atccgaatat agaatcctct cgtatcaata 558241 aaaagtggaa agaagccgtt ttaagtgaac cagatgtaac tgtccatgat ctttatgaaa 558301 aatatcgcga tcaaccaatt gatgtggaat ttgaacaaca gcagctcctg gcccatgacc 558361 gtatcgtttt tcagtttcca ttatactggt acagcagccc accgctttta aaacagtggt 558421 ttgatgaagt gtttacgttt ggctgggctc atggtcccgg cggaaataaa ttgaagggga 558481 aagagtgggt aactgccatg tccatcggtt cacctgaaca ctcttatcaa gccggcggat 558541 ataacttgtt ttcgataagc gagctgacaa aaccgttcca agcatctgcc catttagtag 558601 gcatgaccta tctgccttcc tttgccgaat atcgcgccaa tacaatcagt gaccaagaaa 558661 ttgccgaaag tgcgaatcgg tatgtaaagc atattacaaa tatagaatta aacccgaagg 558721 ttcgcctgca aaggtatttg aaacagctgg agagtgtcga tttaacataa agattgattt 558781 ttgaaaatcc tgtactcacc aagcaggatt ttttcttgtt cagcagaggg attttaacat 558841 atagcaaaaa aagaagaagc caccaaaaat aagctatttg cttggtcctg actgcttatt 558901 tttggtgaaa tacttatttc tctgtgatga aataaagcaa agcgatgacc ggaaaagcga 558961 ttccaatcca taatgctgta ctccatccgc ctgaggcata tgcccatcct ccaattgatg 559021 accctatcgc accgcctaga aagaagatcg ccatgaataa tccgtttaat cgactgcgaa 559081 tttcaggcgc caacgaaaaa atagcacgtt gactgagcac aaggtttgca gatacaccca 559141 tatctaacag aatagcagcg gccactagaa ctgttatacc gacgggggag ctgctctgaa 559201 tcatgagcgg cagtaataaa gagacaacga caacaccgag agcgattcca gtggcaagcc 559261 tggttaagcc tcgatcagcc aggcggccgc ctattggtgc agtgactgca cccgcaatgc 559321 ccaccaatgc gtagagtgct attgccttct gagaaaaatg aaaatcagga ccggacaata 559381 ataaaggaac agttgtccag aacaagctga aagctccaaa tacaaacgca tgatagatgg 559441 cacggcggcg taagactgga gtcgtgcgca gcagcttcca cattgaaccg agtaaggcag 559501 tatagtttgt atttgctgtt ggttttctgg caggaagcac ttttgataat acgatggcca 559561 ggataacact taccacggcg gacaaagcga atattgcatt ccacccccag atatcagcga 559621 ctagactaga tatcggacgg gaaagcataa taccgagtaa taagccgctc atgacattgc 559681 caacaacccg gccgcgtgca gcgtctgatg caaggtatga tgcaaatgga acaagcactt 559741 gggctgcgat tgatcccaat ccgacgaaaa acgcagctgc taaaaacagt gttccatgct 559801 tcacaaatgc tgttagtgtc aaagccgctg cgcttagaag gagcgataca acaataagtt 559861 ttttgttttc gataatatct cctaaaggga caaggaatag taagccggca acgtatccga 559921 tttgggtgag tgtgacaatc aatccagcac cgcttggaga aagtccaatt gccttactaa 559981 ttaatccgac caagggttgt gcatagtaaa gattagcaac aatgataccg catgcagttg 560041 cgagaagaag ggttaaactg ggtgaaatcc tctgacctgc ttgtttgttt ccattagcca 560101 tatgaatgaa ctccttttta agtggttttt tgagtgtaat catgacttct cacaagtgat 560161 tttataaact gaacgttcag tttcgtcgat taataaaaat aatatactaa acgttcagtt 560221 ttgtaaatgg atttctgttt tcttttttta ttcaatttaa gtatactgaa cgtatagttt 560281 atattgcggg aaggaatgat ttatgtgcag agtaaacgag ggcggccgcg tgatgaagga 560341 acgcataagg cgattctctc tgcagcctat gacctattgc tggaaaaagg cttcgatgcg 560401 gtgacagtcg ataaaattgc cgagcgtgcg aaagtgagta aagcaacgat ttataaatgg 560461 tggtctaaca aggctgccgt tatcatggac agctttcttt cgaccgcgac ggacaggctg 560521 cctgtgcctg atacagggtc gtcagtacaa gatatagtaa cccacgccac gaatttagct 560581 aggtttttga caagccggga aggaaccgtt attaaggaat taataggtgc agggcagttg 560641 gatgaaaaat tggcagaaga atatcgcacg cgatttttcc agcctcgccg cctccaagcg 560701 aaaggccttc tagaaaaggg aattcagaaa ggtgaattga gagagaatct tgatattgaa 560761 gtaagcatag atctcattta cggaccaatt ttctatcgtc tgcttataac aggggatgag 560821 gtgaatgatt cctatgtgcg tgatttggtg atgaatgcgt ttaagggagt tcaagctacc 560881 tctgctacag agagtatgta gctgataaga actgcaaaag ctgcggatta tatgacaaat 560941 tggttccatc gtacagtgaa atataagatt tttgttgctg agcggaatca tcgagggaaa 561001 agttctctta tcggatgtcg aaaaagaagt cattcaatcg tgaatacata acatcatatt 561061 attacattcc ttttcatcga ttggaacaag ggttctatac ttcaatggaa taccgcaaag 561121 ttggagtatt taaacaacag gggaaaatcg atggccatta tgtaggtgtc atggcaatgg 561181 aaaaaatact tgcaatgtaa acaggcctct aaagagacct gttttttaat atccagatga 561241 ttgtctagtt tcagcttggg ctctatgacc actcccataa ctgaaatagt ctaatattta 561301 taccagaagg gattgtttat ataaataaaa gtttatataa tgacgggggc gctaaggaaa 561361 cgcggggagc gactcaggtt ttcgtttcaa agttttgatc cttaagatat acggagcgct 561421 acatatggaa acgtaaaggg gaatgtataa tcatttggcg tgtatataac gatttgctta 561481 tatattgatt tgggaaggag gagctcatat gacgattgat gttgcggcga tgactcgttg 561541 tttgaaaaca cttagtgatc aaactaggct tatcatgatg agattatttc ttgaacaaga 561601 atattgtgtc tgtcaattgg ttgatatgtt cgaaatgagc cagcccgcca taagccagca 561661 tttgcggaaa ttaaaaaacg caggttttgt gaatgaggac agaagaggcc aatggcgtta 561721 ttattcaata aatggttcct gtcctgagtt tgatacattg caattgatct tacatcaaat 561781 tgatcaagag gatgaattgt taaaccatat caaacaaaag aaaactcaag cgtgttgcca 561841 gtaaggaggc attagattga catcaatgat tttggcagta ttcatctttt tattaactct 561901 agtattggtc atatggcagc cgaaaaattt atctataggg tggtcagcct gtggaggcgc 561961 agttttagct ctaatagcag gtgttgtcaa ttttcatgat gtgttaactg tgacagggat 562021 tgtttggaat gcgaccttgg cttttgtggc catcatactg atatcgttaa ttcttgataa 562081 tatcggtttc tttgaatggg cagcgcttca tatggctaag gctgcaaaag gatacggtgt 562141 gcggatgttc gtttatgtat ctctattagg agctatcgtc gccgcgttat ttgcaaatga 562201 cggtgcagct cttatattga caccaatcgt attagcgatg gtcagagcat tacattttaa 562261 tgaaaaatta gtttttcctt ttatcattgc cagcggattt attgcggata ccacttcgct 562321 tccttttgta gtaagcaatt tggtcaacat tgtttcagcg gactattttc atattacgtt 562381 tattgattat gcatccagaa tggttgtccc gtacctgttt tcgctgctgg cgagcatcat 562441 tgtactttac cttttcttta gaaaaagcat accaaaacgc tatgatctga ctgaggttaa 562501 aaaacctgtt gaagcaatta aagatcaaaa catgttcaga ctgtcatggt atatcttagg 562561 gctgctgtta attggatatt ttgcaagtga atttttttct atccctgtat cagtggtagc 562621 gggcagcatt gcaatcattt tcttaatcgc tgcgcaaaag agtccggccg tccatacaaa 562681 gaaagtggtg aaagaggcgc catgggctat cgtattcttt tcaattggca tgtacgttgt 562741 tgtgtatggt gtccgaaatg ccggattaac ggatgtcctt tcagatgtga ttcaagccgc 562801 agctgatcaa ggattgtttg ctgggacaat tggaatgggc tttattgcgg cgattctttc 562861 ttccattatg aataacttgc cgactgttat gattgacgca ttggccattg ccggtacaga 562921 tacacatggg atgatgagag aagcgcttat ttatgcaaat gtgatcggtt cagatttagg 562981 gcctaaaata acaccgattg gttccttagc gacattatta tggcttcatg ttctttcgca 563041 caaaggtatg aagatttcct ggggcacgta ttttaaaaca ggaattatcc tcacgatacc 563101 cactttattg atcacacttg tcggcctgta tatttggctg ctgataatcc attcttgttt 563161 ctaaaaggac aaggtcacta tatcaaggaa aacaatgcac tggtaactct tgccgcagcc 563221 aaatggctga agggtggggg agaaaatacc ttggggctaa gtggaatgtg tacagcgcag 563281 gaatcgaagc tcaaggatga catcgagtgc tgtcaaagca atgaaagaag cagggattga 563341 tatttcaaat caaacatcgg agaaatttga tgatccggca aaagcacacg gaacagaaga 563401 agtgtttcca aagggtccgt gatgaaattg gtgaccgttt aaaacagttt gctgtaactg 563461 gggaataaag aatcgatata ttcagcgttt tcttgggtta tataatacaa tgtgttgttc 563521 aacaggtgtc tgcgagctga gtgcagacac ctgtttttgt ttttatttgt ctgagattcg 563581 taacagggaa gttatttagc tggtgacaga ggaaaattga tttgtgaaca gaatcatgaa 563641 ggagacggtg ttttaaagga gttgtctgtt ttgcaggaat taacaaaaaa aaaatacagt 563701 agcttaaaaa caatgtttga tgacaaatat tgtcccacat ttgtctattc aatattagac 563761 caaaccattc cgggagctgt ttatgcagat gatcaaacct ttcctaaatc gttttttata 563821 ggaactgaat caggcattta ttttattgcg ggagaccaag ggaatcggga ttttcatgat 563881 ttcattgcag gatattatga agaacaagtg aaatcatcaa aacgatttac cttgttttct 563941 tccagtgata catgggatag cgtactgaaa cccatactga aagatgactt aaaccaaatg 564001 agaagagctg cattttctta tcaaccaaaa tctttcaaaa agactttgca actgccaaag 564061 gggcttgtat tgaaaagaat tgacgaagac atcatttcac atagcacagc gtttaacagc 564121 gcgtattatg aggagtattg gaattctgtc tcacagtttg cttcaaaagg ttttggattt 564181 gccgtattac atggcaatca cgtagtaagt gagtgtacct ctatattttt agggcataat 564241 cgagcggaaa tggatatcta tacacttgaa gaatatagag gactggggtt agcttattgc 564301 gtagcaaata ggtttatagc gttttgtatg gaaaatggga ttgttcctag ctgggattgt 564361 gatatttgca acaattcgtc cattgcatta gcagctaaac tagggtttaa gacggtaacg 564421 gaatacacta tttactactc tggctaacct taatgaaaga accttaaaag gagataccaa 564481 ccgatgttgg tatctttttt gttttagagt ttttttaccc ttttagcaga aaaatgggtg 564541 atgaaaatct tattcatttt atttactttt aggtaggtaa aacatacccc gccaactgta 564601 accactccgc ctagcagaga gagcagtgtg ggtatctcgc cgatccagag ccaagatatg 564661 atcaaggcta aagccggtgt aacataaagt gaaagggttg cttctgaagc accgacgaat 564721 gaagtgacat atgctagtgc gaagtaagga ataaccgtcg gcaataatcc taagtaaacg 564781 atagacaaag ttgcgcttat tgaagcgttc atcatctctt cgcctaagcc tggcagaaac 564841 acaagcatag gtattgttcc gccccaaatg gtgaatgtaa cgaatggaat aaaaccatat 564901 ttttttatat agcgggcttg aaaaacgaaa taaatactct ccgaaaatgc tgccagcagg 564961 atgaccaaga taccgctcat tgaatatgta aagtctcccg ccccaaatgc aatcaataat 565021 acacccaata aactgatcat agagccaagc catttcgtaa atccaaaatg ctctttataa 565081 aacaggcggg atagcatggc tgagaagatc ggtgccgtag taacgagtaa gcttgcaact 565141 ccggcactaa ctgttttttc accgatgttc agcaaaatgt gatagaatgc aaatcctaaa 565201 aaccctaaaa gaaaaatggc aggaatgtct ttcaagtcgg gtaggcgcat ctgagtcaaa 565261 acagcaaaaa gcaataatgc catagagccg attaacaaac gaaataaagc aaggtgttct 565321 ggcgtgtacc cttcaagtcc tgcgcgaatt cccggaaaag cagatgccca taaaccaatc 565381 atgagactat gagatatcat tatttgaact gttttctttc gcattcctct cactcctctt 565441 tacaaaaacc aaccagttat ttaatgtgtt tctatactaa taaagatttg atgatatggc 565501 ttcaaccagt tcaatagatt ttgacccaac caatttattt taaggagacc gattctatga 565561 gctttccaga agaaaaaaag atgaaaaagc tccctaagta cagacaaatc gttcatttta 565621 ttaaagagaa aataggaaat ggagagtggc cgattggaag caagattcca agccagcgca 565681 cgcttgcaaa agattttcag gtaaatcgga gcacagtgat tacagcgtta gaggaattga 565741 tggccgatgg gctaatagaa ggcacaatgg ggaaaggcac agttgttatc aacaacacat 565801 ggacactgat ggctaagaat tctgctcccg attgggatca atatgtcacc tctggcattc 565861 agatgccaag ccgaaaaatc gttcaagaga taaatcaatc agaatcaaat acagacctta 565921 tacagctcag taaaggtgaa ctttcagctg agatttttcc tttggctgtt atgaaagaga 565981 tgatggggaa ggtatctcaa cacatggagg cattcggata tgaagaacca aaaggttact 566041 tacctttgag ggaggcatta agcaactatt taaaaaccat tggaatcaac gtctcatctt 566101 cttccattct gattgtctca ggagcgttgc aagccttgca gctgatatca atggggctgt 566161 tacaaagagg atcaaccgtt tatcttgatc agccctccta cctttattca ttacacgtat 566221 ttcaatcagc tggtatgaag ctgactggac ttcctatgga taatgaagga cttttgcctg 566281 aaaatgttca tttaacaaga ggagagcggg gaagggctat cttatataca aatccatgtt 566341 ttcacaatcc gactggtatt cttatgtcta aaaagcgacg ggaagaaatc ctagcagtaa 566401 gtgagaatac acagcttcct attattgaag atgacattta tcgtgagtta tggatcgatg 566461 aaattccgcc atatcctatt aaaacaattg ataaaaatgg acacgtactg tacataggaa 566521 gtttatcgaa aacattaagc ccaggtttga ggattggatg gatcgtcgga ccggaaccgg 566581 tgattgaacg tttatctgac attaaaatgc aaacagatta cggatccagt tcgctatccc 566641 agagagtagc ggcagagtgg tttacttccg gccactacca gcagcatgta gaaaaggtta 566701 ggcagcaatt aaaggtgaga agagaattgg ccttgagtgc tttagaaact catttgaaag 566761 aagtggcgac atggaatatc ccaaaaggag ggttttttgt ctggataaaa atattgcctt 566821 ccatatcaat gaaattactt tatactaaag ccttatcaaa agggattctg atcaatctcg 566881 gcagtatcta tgctcaggaa aaagggaatt atattcgctt atcatatgct tatgcatctc 566941 ttgaagacct tcaaaagggg atttatgagt tgggtttaat gattaaagaa ttggcaagca 567001 ggtaactttt atatccttaa atggatgttt cactaaaaaa gagatcaagc ctaatgatcg 567061 cttgatctga taataacaag ggttactaga atagaccaaa tcatggttcg gtcttaaaat 567121 aatcatgtct ctgaacgaaa agtctttccg acttctcttc ctaaaccaaa gtagtgtctg 567181 aaattataga taagcgggct ccatttggaa gggttgatat ggttttcgtc cagaatgata 567241 ctttcctcgg catgaaaatg tagtgcctgc gtctctacaa ttgcgaatga cgattcatat 567301 tctggaagcc gaatgtgttt cacttcggct tcgatttgga tagggcattc tttaattcgt 567361 gttggtgata ctgtttttga ttgtaaaggc gttaaccctg ctgcctcgta tttttctttt 567421 ttatatgtaa atccgatctg cttctttaaa ggcggtatac tcttttttcc gctataagat 567481 gaaattcttt caacgttttc ccataaatcc gggccaggca agtttatgac acactctttg 567541 tgtctttcca aattgtcgat ggcttttcct cccagtccta ctccaaggat tatataatgt 567601 ccaagagccc aagaagaaga cataggacta atattagtgg ttccatcctc attcaatgtg 567661 gttagaagaa atgtcgaggt accataatac atgatcttgg gtttgatttc cttaaatcga 567721 cgagtgtctt gttttttgat gtccaacgtt ttttcctcct tgtcacgctt acatttatat 567781 tgtaaaggat taacatttca actatcatcg aaatatgaat gtaaggagga aaatcatgaa 567841 tcctaatatt gcaaaaatct cttcgttgct atcagatccc tcgcgttctt ccattcttct 567901 cagtctgatg gatggaagga tacaccctgc gggagagctt gcatatctcg ctaacattaa 567961 acctcaaact gcaagttttc acctgaataa attgcttgaa gcaaagctga ttagcgtaga 568021 gaagcatggg agacatcggt attacagatt ggctgactca gatgctgcaa atgtgatcga 568081 acaattgctt catattgcgc ctaaagcaaa agtcaaatct ttaaaagagt caaaagagaa 568141 aaaggacttg catttcgccc ggacctgtta tgatcatttg gcaggttatg tgggcgtgca 568201 aatggcacat tcactagttg agcaggggat gttaaaaaaa gttgatttaa actttgaggt 568261 gacttcagag ggtgctttat tcttttcgaa gttaggcatc aatgaagagc aacaacggaa 568321 taagaggaga gcctttgccc gctgctgttt ggattggagt gaacggcagc atcatattgc 568381 aggagcatta ggaaacgccc tattggtgcg catgttagaa gaagaatgga tcgttcgtat 568441 gcctaaaacg agagcgatta ggattacaca aagcgggaaa atcgcgtttg aaaagcacct 568501 aaacgtgaag atttaggatt ttgaagcgga aacatcagat gatgaggcac gatatctagg 568561 aggagtaaga tttgttctaa tcttactcct tcttcttatt ttgaagcagc tcgattcccc 568621 attgcaatag agatgcggtt ccaactgttt atttgattaa tgatcagaac aaggtcaaca 568681 tattgttcct catcataatg ttcccgcacc cgatgatata gctcatcagg aaccctttta 568741 gatggaatga gcgtgatgtg ttcagatagt tcgagagccg ctttctcttc aggtgagtaa 568801 aaatcacatt cattccaagc atgtaaacag taaattcgct gttcagtttc tcccattttg 568861 cgggcatcgg acgtatgcat atctatgcag aaggcacagc cgttcatttg agagactctg 568921 attttgatta gttctctcgt cgttcggtta attgaggatt gtttcgtgta tttctccata 568981 tccatcatga ttttcatacc ttcaggtgca atctcatagt aggacactct ttgactcata 569041 aagcaagact cctttccata gaatacctag attgtatccc ggtattgatc attttaccaa 569101 tgtgcggttt gaatgacagc tgtttcagcg tcttttggaa agaagcttct ttgaataaaa 569161 ataagggtag ccagcaatga tgagtggagc tgctaatgca agcagtatcc atgagcctga 569221 ttggctgtct ctagtgactc taatgaatat ataagtaccg atcagaaaat ataataaagc 569281 acctagaaac caatacatgt tcattcctct ttttccttgc tttttggttg cgcatttttg 569341 tctgtcatat ggcttaatcg atcagggttc tgatttttta ataccttttc ggtccggatt 569401 ccttttctct ttaatgataa aattgtgaga tcaatcgatt tcaatgatga tcattccttc 569461 aatgaatagt aagttcctta tgattttaaa ggtaaatttg aaaagataaa acgtacatag 569521 aggcagaacg ttcatgtacg tttgggcaat gatcacttgt tggaaactct aatgtttccc 569581 tgcacctgat attgttgtgt tccttctctt cctataaaat gattggatac atgtatgttt 569641 gcacgttgaa atatgggttc gattttcatg aatctctatt cggtgaaaca ggtaaaggaa 569701 gtggataagg tttgcttata aggaatcctt ttaaagataa atattactca catgataggc 569761 gggcattaaa catgcttgca ctcagagtgc cgggcctggc ttttattctc atgatctata 569821 tagcctctat cgtgctgcaa tttgtttctg ggggctggtc cattttattg ctttatgcgt 569881 ttaccatatt aatcgccatt tttgctttgc ttcattggca ctcatatcgc tgggttaaga 569941 aaagagtgat tctgtatttc gcggtacaag gtttgatcac ctttgcactt gctaatctca 570001 tgactggctt ctttatactt gtgattatcg gcctttatgc atttttaatt ggacaaatta 570061 taggaatggc agacagaaga aggacttttc tcattcttta tctattgctg ctgctggtca 570121 taaattcggc gtatcacctt cataaaggtg aagttttgca ttttattgtt attgctgcgc 570181 cgatcatgat tgtcatcatc acttatgccg caacattttt tgcccaagtc gatgaaaaaa 570241 taaaagctca attgactctt gaaaggctgg agctggctca tcagcaggta gaacagctga 570301 cgctgcagaa cgaaagacag cggatggccc gagacttaca cgatacgctt gctcaaggtc 570361 ttgtcagttt aaatatgcag ctggatgcga ttcatgttca tctcgccaaa ggcaacacag 570421 agagagcgaa ggaaatcata caacaatcga tgaaaagagt gaaaagcaca atagctgatg 570481 cacgttcagc tattgacgat ctccgcagca aatcagaaga aatcggtgtt ttaaaagaaa 570541 gaattacctc gctaatggat cattttatag agtcgacagg catggcttgt ttattagatt 570601 acagattgca tcaggtgctg gatgtgcgta cagctgaaaa ctgttattac atcattggag 570661 aatgcatgac gaatgcggca aagcatgctg aggcgaaaac aatctggata tccatttggg 570721 atgatgaaaa gggaaggctc catttaacag ttaaggataa cggcaaggga tttgatgttg 570781 aaaaaggaaa gaaaaagaga ggacattatg ggcttcttgg catacaagaa cgcgtcaggg 570841 caataaatgg ccaattcaat atcaagagta caaaattgaa aggaacacaa attgagatca 570901 ctgtaccaat tcagggagag atgcaagatg aataaggttt taatcgttga tgaccatctt 570961 gtcgtgaggg aaggtctgaa gcttttaatt gaaacgaatg atcaatacac cattatagga 571021 gaggcggaaa atggaaaagt agcagtccgt cttgcagatg aattagaacc ggatatcatt 571081 ctgatggatt tgtatatgcc ggagatgagc gggttagagg ccattaaaca aataaaagaa 571141 aaacacgata cccccatcat tattttgact acatataatg aagatcactt aatgatcgaa 571201 gggattgaat taggagcgaa aggatatctg ttaaaagata cgagttcaga aacccttttt 571261 cacacaatgg atgcagccat cagaggaaat gtgctattgc agcctgatat ccttaaacgt 571321 ctgcaagaaa tccaatttga gcggatgaaa aagcagcgca atgagacgca gctgacagaa 571381 aaggaagtca ttgttctaaa agcaattgct aaaggtctta aaagcaaagc gattgccttt 571441 gatttgggcg tctctgagcg aacagtaaag tccagattaa cgtccattta caataaatta 571501 ggcgcgaatt caagaactga ggcagtaacg attgccatgc aaaaaggtat tctgacaata 571561 gacaactaaa ctgcatattt gaaaattgcc caaacgtaca tgcccgaatg tacgtttttt 571621 tcatttcatt gtcaactaca atgagaaaga atgtgatcaa gcaatgtgtt gaaaggagat 571681 tatcatgtca aaaatgttat atacattagg aggatgggtt gctcgcaatc gcataaaagc 571741 aatatgtgcg tggatcgttg tgttagttgc tgcgataggc cttgcagtga ccttgaaacc 571801 aagtttttct gaggatatgt ccatacctga cacaccttcg gaaaaagcga tggatgtgat 571861 tcaaaaagaa tttcctcatg gtcctgataa agggagcata cgggttattt tcggtgctgg 571921 tgatggggag aaacttactg ggaagccagc aaaaaaagca atagaagata cgttcaaaga 571981 aatcagtaaa gatgattctg ttgactcgat tgcaagtcct tttgtgacag ggacaatcgc 572041 gaaagatggc acagttgcct atgctgatat ccagtataaa tcatcagcag atgatataaa 572101 ggattactct atcaaacact taaaagacag tttgaaaatg gctgatgatg aaggattgca 572161 aactgagcta agcggagatg taccgggagc ggagatggag ataggcggtg tctctgaaat 572221 tgtcggcatt atcttggctt ttgtcgtttt agccattaca ttcggttctt tattaatagc 572281 aggtttgccg attttaactg cactgattgg tttaggtgta agtattggac tggttttgat 572341 tgggacacaa gtatttgata ttgcttctgt cagtctttca ttagccggaa tgattggcct 572401 tgctgttggt attgattatg ctttatttat ttttacgaaa caccgccagt ttttaggcga 572461 aggcatacaa aagaatgaat caattgcgag agccgtggga acagcgggaa gtgcagtggt 572521 ttttgccgga cttactgtta tcgttgcact ttgcggatta actgtcgtta acattccttt 572581 tatgtctgcg atggggctga cagcagggct tagtgtactg atggctgttt tggcttccat 572641 cacacttgtg cctgcggtct tatcgattgc agggaagcgg atgattccga aatcaaacaa 572701 gaaaatagaa aaacaaagca ctgaaacaaa tgtctgggga cgctttgtca ccaaaaatcc 572761 tatcatgcta agtgtatgca gcattctgat tttgatcgtc attagtatcc catctatgca 572821 tttggaactg ggcttgcctg atgctgggat gaaagctaag gataatccgg atcgccgggc 572881 atatgacttg cttgccgaag gctttggaga aggatttaat ggccaattaa caatcgtagc 572941 ggatgccaca aatgctacag aaaataaggc ggaggctttc gcagatgcag tgaaagaaat 573001 aaagggctta gaccatgtag caagtgtcac tcctgcaatg cctaataaag aagggaactt 573061 tgccatcatt acggtcgttc ctgaaacagg tccaaatgat gtcacaacga aagatttggt 573121 acatgatgta cgcagtttat cagataaaaa cggagtagat ttgcttgtta ctggatcaac 573181 tgcagtgaat attgacattt cagatcgcct gaatgatgcg ataccggtgt ttgctgtact 573241 tattgttggc tttgcgtttg tattgctgac catcgttttc cgttcgctgc ttgtgccgct 573301 tgttgctgtt gcaggtttca tgttgacgat gacagccact cttggaatct gtgtatttgt 573361 cttgcaagac gggaatctca tcgacttttt caaaatacct gaaaaagggc cgatactcgc 573421 gttcctgccg attttatcga ttgggattct gttcgggtta gccatggatt atcaagtatt 573481 ccttgtcagc agaatgcgtg aagaatatgt aaaaacaaac aatccagtac aagccattca 573541 ggctggatta aaacacagtg gtcctgttgt tacagcagcc ggcttgatca tgatcttcgt 573601 ttttgcagga tttatctttg caggcgaagc ttctattaaa gccaatgggc tggctctttc 573661 ctttggtgta ctctttgatg cctttattgt aagaatgaca ctgattccaa gtgtcatgaa 573721 gctgatgggg aatgcagcct ggtatttgcc gaaatggtta gacaagatta ttccgaatgt 573781 ggatatagaa gggcatcaac tgacaaagga aatacagccg gaaatagatc atgaacaaaa 573841 gaaacaaatc agtgtgtaat agaaaaagca gatcttttat gatctgctct tttgcttatg 573901 gtagtattta gaagatgaag tcggcagtta aaaggagacg cttatggcgc catcactcat 573961 tttcgatatg gatggaactt tgtttcatat tggcagaagc tgcatcatac tagcaggcat 574021 cccaggagaa gtgacatgat tttttgactt tgcattcact acttgatgcc aaggatcttg 574081 agaatccttc ttgaaaataa aggattttac aactgatcat ataagaaacc taaagaaaca 574141 agcacacaaa accagctgcg ggttttgtcc aagaaaaata gagtccataa gagggactct 574201 attttttgaa gtgcccggct agaagcatat tgcaggactt tatgaatgca aatcactatc 574261 ttataagccc ttaccgtgaa atgcctgttt ctgcattgaa aaaacgcatt acacgttcat 574321 ttacgtaagt gggttgttcc atcgataaaa catgtccggc atttttaatg acttccgcct 574381 caatatctgg aacgaatgaa gaggctcggt gcagggctga gtggggatca tagatgactt 574441 catgttcacc aagtaataat aggataggaa ctcttgctga acgtaattcc tcatcggtaa 574501 aaacatacgg aaatccgtcg gcattaggat ttggatttct tgatccatcc tgccacatta 574561 cccctgcctt aaactgcttc acaaaaatcg ggtgcagcac attctgatca ttcatcatcc 574621 aatttaagaa tgtttcaact ccatttgacg ctgtaaggcc aagagcgtat ttgtagaaat 574681 cgtgatgaaa tggcaaaaac gtttctgccg gactcagtat agctgcgctt tttactctct 574741 caggcatacg taaaaggaaa ttcatcgtat ggagaccgcc aagcgaaagt ccgatcatgt 574801 gggacttttc gatccccaga ttgtcaaaca catcaagaag ccaattggcg taatccgttc 574861 ttgtaccgct tacattctca ggaatactct tgtttttatc acctatgata tcaactgcat 574921 aagttctgta tttactgctc caatcggcga tgttgggata ccacatcgtc gagctgaata 574981 atgctccgtg gagtaataca agcggcgggg catcctctgg gccgcttgca atcacatgtg 575041 tttgaccaaa acgagtagat atatagaatg atttacaacg gaccggccaa agactaaggc 575101 tttcattata agtttgataa tagcggatac cgttgtcact taattcggga atactagatg 575161 aatggtttga catacaaatg cccctcccaa ttttgtttaa atgaatgtgc cgtttcgtga 575221 tggggaatct gattttgata taacagactt tatttacaat ataatacagt tgttattaga 575281 cgtcaaatcc aagatgaaaa ggaaaaaaac gattgaaaca gattattgaa aatcaatata 575341 acagaatatt aacctccttt gtggagccgc ttcattaaaa ccgcaatcca aatgcatgaa 575401 tcacaaaaat cacaacagga gggatcagga gggaaggcag cagattcagt gttttgaact 575461 tcttgattcc aagaatgctt agacctgaac tgaggatgag tatgcctccc acaattgtga 575521 tttcattaat aaggtctgta ttgattgcgc tctccattac ttgtgcaaat aaatagatgg 575581 agccctgcca ggaaaataat acaagtgcgg cagccgctat tccaaaacca aaagttgaag 575641 cgagcacaat ggaggtgatc ccatctaaca tcccgtttgt cagaaggtat gtataatctc 575701 catgcaaagc ggcttcaaca gggcctaata ttgacagcga acctatacaa aataataaga 575761 ccgcagttga taagccctct gctaaattgc ttttagaaaa tttgttcacc agcttgttga 575821 atcgtaattc taaattgatg atctggccta gcaaacctcc aatggctaaa ctcacgatga 575881 atagaatggg gtatttacta tcaggcaaat gctgtgtaat ggcgttgatc cccagtgcga 575941 ccgcagcgaa tcccattgcc tgcatcaaaa tatcctggta ttcatcttta atgccttttt 576001 tgaatatccc cccgattatg cttcctgcaa tgatcatcac tgtgttaaaa atcgttccaa 576061 acataagctt tctcctccaa aaatcattcc tgcataaaaa ataaaccctc tagttagtag 576121 agagtcaagg gagatcaaaa catattcatg agattatttg atgggcagca ggatttcagt 576181 cacgtaatta tctaggttat tcgtaatgcc ataatcaatg agtgtgattt cgattgagtc 576241 ccctgctacc tcataatgat gttctttcat atatgccagt aattttttgt agtatggttc 576301 ggcttctgga tgtgaccctt taaacctaat ttgcagatat tctcttgaag gaaagatgat 576361 ttctgaagaa gttttttcat tttcatcttc aagaatcata aatatactgg aatatttgtc 576421 aaactgtttt gctttcacat ttgctgcaga aatggataaa ccaatcttgc ctatgaatat 576481 atcttcgttt acattcaggt gggttctcaa ttcagctaac gaatgttcga tatcatggcc 576541 gagaacatat tcatgctgca aataggccac acgcattgcg ggaagtttga tttttgaaat 576601 ttgatgtaac ggcatgttaa cggcatcttc tatatgtgtg atgcgtcggg agatctttcg 576661 ttcaatgcgt tccaattctt tcttcttgcg atcaatttca acctgctggc tttttagtaa 576721 atgaagaaga gtgtttgtat tttgagagtt ataaaaatca agaagcttat tgattggcag 576781 gcctagggcc ctcaaatact tgatggtatc cagccgctca aactgttggg tagaataata 576841 tctatagttc gtttgctcat ctttatattc cggtttcaaa aggccgattt catcataata 576901 ccgaagagca gagattttca cattgaataa ctttgacact tctccaatcg aaaaaaattc 576961 cttcattcta acaacctttc tgtcctatga ttgatataca cacattatat agtacggcga 577021 gtactaaagg taaagtttgc agcataaaga aaaaactcct tctaaaaagg agcttttcat 577081 tcttcgaaat aaggatttac atggatgagc acttcttcta catctgaaaa ctgtcttttg 577141 atttcatttc gaatttcgcg ggcaatgtcg tgtccctgct taattgtcaa atcatgatcc 577201 aaagataaac ggacatcaag caatttatag tggccatgtt ctcgcgcgcg gattctatca 577261 attcgtttta cctgatcaca ttgaaaaata acagctttat attcctctat cagctcggga 577321 tcaacactct tttccatgag cacatcaaca gacggcctga ttaattccat tgaaatctta 577381 aaaatgaggt aagcaacgat tgcactggca atggcatcgg cgtacaacag ataggaccat 577441 ccacggctgt ttccgatgat agccaacagg acgccgataa aagcggcaag agaggcaacg 577501 atatcgcctt tatgatcgta cgcaatcgct ataatcgctt tgctgttcca ttttttccct 577561 tgctttatag aataacgata taagatttcc ttagccacgt acgaaatcag agccgcaaac 577621 aatgcgctgt attggggaac gcttggccct ttaacaaagg acagaatcgc ttctatgagg 577681 atataaacgg atacgatcac taagataatt cctacaatcg cctcactaat gacttcagct 577741 tttccgtgac caaaaggatg gtcttgatcg ggcggtttat tggaaattcc gatcactgcc 577801 aagactgcaa tcgaagcaac gacatctgcc gcggaatgta ttccgtctgc aaacacggct 577861 tcactatcgc ctaccagccc aaaaaagacc tttcctgcca ttaagatcag attggcgatc 577921 aatgcaatca aagcaacttt tctgcttatt tgttctcttt cacttgccat tttttcctcc 577981 tataaaactg cacaaaaaaa taggagtgct ctatatacgc tctccgtatc ctttcctgtg 578041 taatcacttt gtttatcata ccaattcaat ttcgagtggg tctatagcaa cgttgtttcc 578101 tgtttactaa taaataaggt gacagaaaaa aagttggagc tatgctaaaa aggtcataca 578161 gcaaacaaat gagttcttat gtaacaacag tgatgattcg ctattaaaat gctgccgtca 578221 gtgaaaaatt tccacctaat tttcaaaaac ctattgacat gagaagatct gtattttact 578281 attatctcat attcaagata ttttaatttg agatatttgg tcggaaagat cagcgatcaa 578341 gcgcaactct aagtgttcaa tcgttgtcag ttcttttaca caatattcaa tatgattttt 578401 tataacataa tatctcgaat tcgagataaa agggagtgta gcgtaatggc tgaatttact 578461 catttagtca atgaaagacg atctgcaagc aattttcttt caggtcatcc aatcacaaaa 578521 gaagatctca atgagatgtt tgaattggtt gcattggcac catcggcttt taatttgcag 578581 catacaaaat atgtgacggt tcttgaccag gacgtaaagg aaaagctgaa gcaggccgca 578641 aacggacaat ataaagtggt tagctcttct gcggttctct tggtattagg ggataagcag 578701 gcatatcaac aagcggccga tatctatgaa ggtttaaagg tattggggat attaaataag 578761 caagagtatg accacatggt gcaagacacc gtttcgtttt atgaaaacag gggagaacaa 578821 tttaagagag atgaggcgat aaggaatgct tcactttctg cgatgatgtt tatgctgagt 578881 gctaaggaaa aaggctggga tacctgcccg atgatcggct ttgatgcgga agccgtaaaa 578941 cggattttga acatagacga ccaatttgag gttgtcatga tgattacgat tggaaaagaa 579001 aaaacagaga gcagaagacc gcgcggctac cggaagcctg tgaatgagtt tgttgagtat 579061 atgtaaaagg agcggataaa aatggctaaa aaaacgatgg gaattcatca tattacagcg 579121 attgtcggtc accctcaaga gaacacagat ttttacgcag gagtgcttgg gcttcgtttg 579181 gtcaagcaaa ctgtcaattt tgatgaccca ggtacgtatc atctttattt tgggaatgaa 579241 ggcgggaagc cgggaacaat cattaccttc tttccgtggg ccggagcccg ccaaggcgtc 579301 attggagacg gtcaagttgg cgtgacttcg tatgtcgtgc cgaaaggggc tatggcattt 579361 tgggaaaaga gactagaaaa gttcaacgtt ccctacacca aaatcgagcg ctttggggaa 579421 caatatgtag aatttgatga tcctcatgga ctgcacttag aaatcgtgga aagagaagaa 579481 ggagaggcta atacgtggac tttcggagaa gtaacgcccg atgttgccat taaaggtttt 579541 gggggtgcaa ccctattatc agagcagcct gacaaaaccg ctgacctttt agaaaacatc 579601 atggggctgg agcgagtcgg caaagaagga gacttcgttc gttatcgttc cgccggtgat 579661 atcggaaatg tgattgacct taagttaacg cctattggcc gcgggcaaat gggggccgga 579721 acggtgcatc acatcgcttg gcgggctaac gatgatgaag atcagttaga ttggcaaaga 579781 tatattgctt cccacggata tggtgtaact cctgttcggg atagaaacta ctttaatgcc 579841 atttacttca gggaacacgg ggaaatcctg tttgaaatcg caactgatcc cccaggcttt 579901 gcacatgatg aaacacagga aacaatgggc gaaaaactga tgctgcctgt gcaatatgaa 579961 ccgcatcgca cacaaattga acaagggctg ctgccgtttg aagtaagaga gttagattga 580021 tttgacacat aaaaaataaa gaaacatata ttcaattgat gattgctgga tggtactgtc 580081 agcaaagaat cagataaaat caaagatgag gagagataca aatggaagat gcaggactgt 580141 tgcttattcg tataatgatt ggtgtggtgt ttttgtttta tggcacacaa aaattattcg 580201 gctggtttgg cggatacggg attaaaggaa ccggacaatg gttcgaatca attggggtga 580261 aaccaggaaa cgttgcggcc gctctatcag gtcttgggga gttagtaagc ggaattctat 580321 ttattttagg cgtattcctc ccgcttggag ctgctatcat aacaatcatc atgttaggtg 580381 ctatcgtaaa agtccatgga gcgaaaggtt ttgcgaatgg cgccggaggt tttgaatata 580441 acctggtgct cattgcagtt tccatagggg ttgcactcat cggttcagga gcttacgctt 580501 tgcattttta atacgaaagt atgtaagaac agttgctgct tgtcagtaac tgttctttta 580561 ttttcacatt ttcggcaagc ttgcaggtac tctgcaaagc aaaaaagcgg atatcataaa 580621 tataaatctg tatagtgaat gatacgtatt gatgagcttg gtcatgaaaa acagacctat 580681 ttgaaggagt aaatggatga aagagatgac aggattacat tcattagttt ctatagaaaa 580741 ctttatcaaa cagcacaaat tcagttttat ttatatatca aggcctggct gtacagtatg 580801 tcacgcagtt ctgccccagc tcagaatagt attggatcag tttccaaaca tcaaattggg 580861 gcatatcaat gctgacgatg tagcagaggt cgccggcaga ttttcagttt tcaccgttcc 580921 tgtgcttctt ttgttcattg atgggactga gtttctaaga gaagcccgtt ttgttcattt 580981 tgaacagctt gaacaaaagc tgaaaagggt ttatcgatta tatgaaggcg aataaaggaa 581041 taaggcaaaa aaagaactca aatgagttct ttttttattc ttcactaggc gaagaagggt 581101 tatcaacctg cccttgatca cttgtatcat tatcacaact tgctgaaata ataattgaat 581161 gagaaggaga gtaatctcct aatgtgaaat tcactccgta atttttgctg ttcgcagtat 581221 ggctgttttg caagttttgt ccgatatctg tattggcgtt ttgtgtcatt ccatttatcg 581281 tgagatttga gatgttgatt tgagatcgca tgcttcaaaa actcctttca ctcagaagta 581341 gctgtcataa aggacgctgg cagtctattt acttctatga tattgcgttt ttatatcatt 581401 gcatcaacat aatggtaaaa ataatagcga gtgaatgatc atcttttgaa gatgatcaac 581461 ctatcagcag aaataaagcc gcctgataaa gaggcggcag atcgttatat gtcatctatg 581521 aatttgatgt atcgtttttc gtttgcctga aggataagat agtcgttttt aatgatgagt 581581 aggagcctat agcagcgtag ccataaaacc agcccataaa tacgccagaa aagaggctgt 581641 gtcgatggct tatgaaaaca gaaatgacaa ggcctgttat taaggcaact gacggtacaa 581701 aagttttggg gattttcaat aatattttga ggatttgggt tatcaatatg atgattggaa 581761 cagctatcac agcatcccaa aagttcgtgt gaataattgg aaaagccata cggcacctca 581821 tgaagtgttt atttcttaat ttttacgcta aaagcttgga aagcagctct tggatcgcat 581881 atgttacatt ttgggcttga ttggcggagc ttgtttggct taaagcattg gattcaaaaa 581941 ccaaacctgt attactccca ccggaaccct ctgttgtttt agacacagag aacgggctga 582001 tggaaactgc aaatccgtta ttaaaaacgc tgttcccgga tatcgaatga atataaactg 582061 ggaatttcat cattcatctc tcctctctgt tatgactgtt tatacaatat ggtgtgtgag 582121 cagcagttgc ttaaacaaaa cggcaaaaac tttcagtaag agacaaaaac ctgcaaaatg 582181 ccacaagcgc cttttgttaa tgcagctttt tagggacgtt ttttttattt tttttgccaa 582241 cttcatcaaa aatattctga ttgccagact gggcttgtcc gtccttattt atgaaatcgg 582301 ggtgaatgag ttttttcaga tccctgactg ttaaaggctt ggcgtcatca gttaattcta 582361 ttcctaattg cccgtttgcc tctaatgtcg caattttgac atcttgtata gccgtaacgc 582421 cgtgaagcct tagctgcatt tcaagctggt cagctgtaag tctcatcttc tttaagtttt 582481 cgatatgaag ctgtccgttt tcaatgacga tttttgcttt tccggttaac atcttttcaa 582541 tggtgttcga tttcatttgg atccattcca taacgatgag tgtgcttgtg aaaattgccg 582601 ctgcaattaa tgttttgaag aggctgtact cgatgattgg ctgaacgata atagttccga 582661 tcgaaatcat gacaaccgtt tgagtcgacg tcatttgtgc gattgatttc cttcctgaaa 582721 ttctcagcaa aatgaccccg gctacaatga gaacaagaga ttcccaagtg aaattcatgc 582781 taccacctga ccaatgatga attagatttg tcatgggatt ggcttttctt ccggccaatc 582841 gcaatttaat atatccgaaa ggcagtcggt tcattctgtc ctgaaccgaa caatattttt 582901 ggtatagatg gatatattaa gccaaacaat gatagcaaca ggagtttttt ggccgaaaca 582961 atctgggaag cggggagcgc cataacatga ttgaacttga agttgtcatt agaacggttg 583021 ccagctttgg cttgctgtta atcgcagaac gaattttagg caaacagaca atctctcaaa 583081 tgacgatttt tgattttatt gcggcgatca cactaggggc gattgctgcc ggattagctt 583141 acaatacttc aataaaaccg cacaatatgg ccatttcgtt tagtattttt gtgctaacca 583201 tttttctaat ttcgtttctg tcgataaaga acaggaagct gaggaaattt tttgccggag 583261 atccaacagt gctgattcaa aacgggaaga tacttgaatc aaatatgagg aaaatgcgtt 583321 acacacttga ttatttaaat cagcaattac gggaaaaaga aatatttaat atcgaagaag 583381 ttctttttgc cattcttgaa acgaatggtc agctgactgt gttaagaaaa ccgcaattcc 583441 ggcatgtgac caaacaggat ttaatgattg cggtaaacca agaacaaagg cttccgatag 583501 aacttattat ggacggagaa atcattgaga ataatttaaa gcagaatcgt ttgacggaat 583561 cctggctttt ggaagaattg cgaaaaagag acataaaggt gaaagagacc gtgtacgcag 583621 tgctgctggg taatggggat atttatgtgg atcaatataa agaccatata tcagtcccta 583681 tggataagga atgaaggaac aatcaatctt aaagcccctt attgaacgca acggtttcaa 583741 cttgtcttgg gtacgaaata tgcagaagcc cgtttaacag ctgaatctgt aacaaatgag 583801 tttcagcggc ttcgggaagc tgaatgattc gctcaatttc tccgtaatac cgttcacgca 583861 gcacttccat ttcggctgga aaaacaggcg tgatcgttcc tttgatcagc agctgggttt 583921 tagacagtaa acggatcgtt aattcttcct catacacacc gggcatttcc acaatgataa 583981 aattatattc ctcatcttga taaaagtcgt aaacaaacgt agaagcttcg gaatcaaaaa 584041 aatgttccgg ggctttatat ttgagcacat ttgtccaaaa gtcactttgt ttatattcat 584101 tcgtaatctc aagccacttt cgaatttttt cgaaatccat atgagattct ccttaaattt 584161 gatttgaaat cggcgcagaa gggtttccga tttggtcttg gtcactaacg tctgaatcaa 584221 tatttccagt gtttaaaagt gaagacgtag gcgaaagatc ccctaaggaa aagtttgctc 584281 caaaatattt gctgttcgca gtatggctgt tgtgcacagt cggaccgaca tctatatttc 584341 cgttttgcgt gacgccgttg atcttaatat ttgcgatatt aatttgatat ggcatagacg 584401 aaaccccttt aatctaaaat tggcggtggt gcaatcggag gagcattaac gttggatgta 584461 tcagagttgc cgatagatgt ctggtcattt acatcaggat cgtttaagaa gttttccatt 584521 acggattctg taggtgatgt atcaccgaaa gaagagttgg tcccttgaga tttttgattg 584581 ttggtagggc tgttataagc agcttcgcct attgtaattg aaccattgcc cgaaatactg 584641 ttgatcttca aataatatag gttgattact gtagacggca tcccatcaca cccttccatc 584701 tttctgtaca gtacattatg cgccgctgca cccaattgtt ccttgcattt acgggcaaaa 584761 ctctatctgg ccccggagtg atgctcaatt atcagtgaat gaaaagccat tgatatagga 584821 atcaatgaat tgattcagtt attcgaaatg catgagacct tttaataaag gaagctggca 584881 aacaggatca gtttgaaata attgacaatg aagctaatgc catgaaataa tactcgtgag 584941 taacattact cgtgggtatt atttttgggg tggtcctagt tgaaaagtaa aggagtagaa 585001 agccgaaaac gattacttaa agctgccgct aatgaatttt cggttcgggg attccatgac 585061 gcgaaggtaa gtgaaattgt gaaaaaagct gggttcacgc agccttcatt ttacctgtac 585121 tttcaaagca aagaagccat ctttgccgag ttaataaccg attttcactc tcgagtcaga 585181 aagctgacag agtcacttct tctggaaaac ggattaaaca cggaggatgt gtcaaaacgg 585241 gtactgctag ctgtagagac tgtttttcaa tttttggatg aggacaagga tttaaccaag 585301 atcggctttt ttctcaaccc ggaagcaaaa caaatgaaaa aagacttggc gatggttttg 585361 aaagagaact tagaagcaga acagcggctt ggctattttc actctgaact ggatatggaa 585421 actgtcgctg agtgtttggt cggcatgatt gaacatttaa ccgaatcatt tttgttaacc 585481 ggaatcaaag atccggcaag cctcgcagca gaggttgtga atcttttaat ttacgggatg 585541 cttccgaaag ggaatgatgt aagatgatat ctattatgat gaaagtcagt ttggcagttt 585601 ttatgcttgc gggaggcatc ataaaggtaa gccgcgttcc ctttcaagtt gagcattggc 585661 ggcattatca atatccatta tggtttctga ctgttactgg cattcttgaa atagccgggg 585721 cacttgctat gacagcggga atttggaatc ggtatgcagc aattggagca ggtgttctgt 585781 ttgtcgttct catggcggga gcaattcatg cgcatatgtt tcgagcaaga caatctgtca 585841 tcatggcgat acaagcgatg atttgtttga ttgtttcaat catgatcatc atggggagtt 585901 acacgtaagc ttttcactaa tgtttaagaa caagcccatt tgcaggaaat ctccttttct 585961 tatcgaataa tagaaagtcc aggaattaac tgaatcagta aaatagagct ccatttctgt 586021 gttattcgtc cggcatcagc tgggcttttt ttataaagga ggaatacagg atggcattca 586081 ctttggaaga catgactgag gaagagttcg aagcctttcg cgggatgtcc gtgcaaaatt 586141 ttgcgaaaca aaacataacg tcaggaactt ggacggaaaa agaggcattt gagaaatcgg 586201 agcaggcata tgagaacatg attccgaatg ggcgagacag cagcaatcat tatttttgga 586261 acatcacaaa tgaccaagga gaaagaatgg gctggctctg gctgtatgct gatccattac 586321 atccgcaaaa ggaagcgttt atctattcct ttggattgta tgaagccttt cgcggaaaag 586381 gacttgctca attggcgctt caaacgcttg atgaaagagc aagagagctt ggtgcggaaa 586441 ggctggctct acatgtattt gcacacaacg agacagccgt ctatctttat cagaagatgg 586501 gctatgccat gaccaatata cgtatgcgga aacagctatg ctgaaaagcc gcttacgtta 586561 cccaaataca acatgcctat ctggaagcgg tggcagggta ctataagtca tcattagaaa 586621 gattaaggtc atgggaggct tgaacatata aagaaaaagg acaacagctg ttgtcctttt 586681 caatgccgct tgaactttct ccctcagtct tttttgtctt gatgatccag ctcttttatt 586741 cgtttcgtaa gctcattgaa agcctgatca agctccttat accctttatc atttggcgtc 586801 ataaaactga gctttcccag cacttcttgt ctttctgtct caagctttaa ccgaagctcc 586861 tcccgctcat ttctttctga aggaacgtcg tttaactgct tttcgatgcc gttgtttgag 586921 atgacgagtt tactgtttgt tgttttttcg agaaagtatc ggtcatgtga aaccgccagc 586981 aatgtgccgc tgtattgtga cagtgtttct tccagctgtt cgcgtgacgg caggtcgaga 587041 tggtttgtcg gctcatctaa aatcagcacg tctttttcct ccagaatata tgccatcagc 587101 ttgatcttta cacgctcacc catactcata tgcttgatcg gttcagtcca ttgggcggct 587161 gtaaaaccta agtgcctcat cagattttga acgtgccccc ttgctttgaa tgtttcattc 587221 tcaaataact cttccggtgt ttgttctaaa ggcaaatcaa acacctcctg cgttaaatag 587281 ccgatgtttg cggacggcga cacccataca cttccttctg ctgtttcctg tcccagaatg 587341 atgttcagta atgtcgtttt tccgctgcca ttggggccta tgatcgcaac cttttcgccg 587401 tgctgaattg taaagtttgc gtttttaaag agagtccttt ctccaaacgc ttttgttaca 587461 ttctgaactt ctaaaaaacg ttttcctgtt ttgtgggttg tatcgattga aaagcggact 587521 gtatattctg gggtaacggg ttccgccttt gctttttcaa gctctttttc aagccgcttc 587581 tgcttggatt ttatctgggc atccgtacgc ttcgctttta cccggtgata ttctttaaac 587641 ccttcctttt tcgtcgattg agcatgggct ttttccgacc aagaagcgag cccattcatt 587701 tgtgcttcaa tccgttcaac cattttttgc tgcttttcat attcacgctg ctgggtgagt 587761 cttttcttct cccggaactt catatacccg gagtaattcc ctttgaattc aatcagcgtc 587821 tgatcctcaa gcgaccatat ttttgttgcg gcttcgtcta aaaaatatcg atcgtgagaa 587881 acgagaatca cagtgccgtt ataatgtttc agctgttgga tgagaaattg caagcttttt 587941 tcatcaaggt ggtttgtcgg ttcatctaac agcagcagat ctgcatcctc tgatagtcct 588001 ttcgccagcc gcgctttcag tttttcaccg ccgcttaact gatgaaaatc acgaagaggc 588061 acatgccatt tctccagtaa cttcttttcg gcaggtgtct gatccgcaaa ggaatacgcc 588121 gcggtttcct gttcaaccaa agccagtttt atatccttcc gaaggatttg accctgtgca 588181 ggggctaagt cattgtgaat gaggtgcagc aacgtagatt tcccagcgcc gtttttgccg 588241 ataatcccaa tgatatctcc ttgctgaaca ctggcgttta catgtttaaa aacagtttga 588301 tcctttactt catagctaac gtttgttaat gttacgatct ctttcatcca tatccctcgc 588361 tttaaaggga gaataaaaaa atcctcccaa atgtgttgga aggattagcc gtgcctgtgc 588421 atgatcaaat aagctatttt ttataaatag cagtgtcgta tatatagaaa atgggcagac 588481 taatcctatt ttttgatttg aaatattgat ttcaaacggt aaaaataaga ttagttaatc 588541 attgtccacc catcatccct tcttgttttg attacaaaca ctatagcata cctttaaatt 588601 caaaagcaaa ggtcattttc atcaaaaaaa ctcctgctct catttttgag gcaggagttt 588661 tgagtcttat tgatgcttcg cttttctcac tttataaatc acaatcagca aaataaacca 588721 aaccggtgtg acaaataagg aaacacgagt atcctgtgcc agtgccagca caaccagaac 588781 aaacgccagg aacgcaagaa tcaggtaatt tgtaaacgga taaagcggaa gcttaaactt 588841 gtttgttttc gctaattcag gtcttgtttt gcggtatttc atatggcaga tgaccgtaat 588901 cccccaaatg tagataaagc atacggttga aatacttgtg atcagggtga atacgccttc 588961 tggcatgatg tagtttaacg taacaccgat taaaatcacg atagctgaaa agaataaagc 589021 atttctaggc actttacgct gagtcagttt cgccattgac tcaggcgcat tgtgatcttt 589081 cgccagggaa tagaccatac ggcttgtact gaatacagcg ctgttgcatg ctgaagcagc 589141 ggatgtcaac acaacaaagt tgataatact tgcagccccg acgatgccaa cagcgacaaa 589201 tacttgtacg aatgggcttt cgctgggatt gatgatatcc caaggataga tgctcataat 589261 cacgagaaga gccccgatat aaaaaagcag cacacggaca ggaatattgt tgatcgcctt 589321 agggattact ttttcagggt tttctgtttc accggccgta agcccgacaa gctcaatgcc 589381 gacaaaagca aacacaacca tctggaacga gaggataaac ccgtgcatgc cattcgggaa 589441 caggcctccg tggctccaga ggtttgtgaa gctggacact cctgagcttg tggaaaagcc 589501 tttgaaaatc atcacaaggc caatgacgat taacgccaaa atggcaatga ctttaatcaa 589561 agcgaaccaa aattctaatt ctccaaaaag cttgactgtc gccagattca taatcagtaa 589621 aataataaga gcgattaagc caggcaccca ttgcggcaca cccgggagcc aatattgagt 589681 gtagagcccg actgctgtca gatcagccat cgcaatggaa atccagcaga accaatatgt 589741 ccagccggtg ataaaagctg ccatatcgcc taggtagtct tgtacaaaat ccacaaaaga 589801 gtgatagttc aagtttgata acagcagttc acccagcgat ctcataatta aaaagcaaat 589861 gatccctgtg atcatataag caaataaaat cgaaggtccg gcaaaatgaa tcgatttgcc 589921 cgagccgaga aataagcctg tcccaatggc tccgccgatg gcgatgagct ggatatgcct 589981 gtttttcaag cctctctgca acgtttgctg atttatattg tctttcgtca tgtcgtctgt 590041 cactttatgt gttcctccat tgaaaattgt ttattgagtc agcaatctat ttttaatgat 590101 tattataaca ctaaaatttc tatctttttt actaaaaaag gattgatgaa aagaatttta 590161 atgtgatttg gactatttcc cgaaaaagcg gctccattta gggagccgct tttttatgct 590221 ttttcagttt ttgtcataaa caggtagagc ccgtaatctg tcggtgcgga tgcgtagcct 590281 gcctgccgca gcattgctgt gatattgccg cggtggtatg tcccgtgatt gacaacgtgg 590341 ggaagcagtt cggaaacagt tgttttcatg attccgcttg agggattttg aatctggagt 590401 ggcttattga gctgttcttt ttgctgtaaa aatagtatat agcgctcgga taacctcaga 590461 aaaaggtctt ccatttcctc tatttcttta gcctctgtct gttctttaag ctgttcagct 590521 aaagccaacg catcgctcaa ggttttgccg gaaaacactt caatccagcc gagatcagaa 590581 agataaacat gagacaatac atgggatatt gacggaaaca cgctttgaat ttcttgatgg 590641 tatatctctt ttggaagctc ttttaatcgg ttgaatattt gttgattggc ccagacgtta 590701 tattcataca atttgaatgc aaaatctgac atgttaaaat tccccctttc gtgtgtatag 590761 ctttcattat acacgaacat gagttcttat gtagagtgct cgaaaataaa atttgttgac 590821 atatatagtt tagaggaata aactaattga cattgaacat aaagtttagc ggggtaaact 590881 ataatgagga ggggaagata ttgaatgaac aaaagctatg tcaggcgata aacctgtttg 590941 tggaagtcct gcttgaaggg acagaatttg tgcatcgtga aatcaatcag gatgtcttca 591001 agcatatctc aagggaacag gcagacctgt tgaaaatttt aaaagtcaag ggcccaacct 591061 ctcccggcag cctggccatg taccaaaatg tacataagag cgcgatctct aacagactga 591121 aaaagctgct cgaaaaggga ttggttcaat gggacgactg tccggaaaaa agtgataggc 591181 gctctaagct tattaacatt acacccagtg gtgaacacat actagaagaa ttagattctg 591241 ccatctttaa cgcgctcaaa ccgttgattg atgatataga tgaggaacac ttacattcta 591301 tcatcgagat attcaccatt ttaaaaagca aatttaaagg aggagattct gccgaatgag 591361 agcaatcatc aaattcaagt gggcaattgc agccatagta ttagcactta ccgtcgtttt 591421 gagtttgttt tctccgaact taacggagct ggccaatcaa aaggggcagg cccagcttcc 591481 cgctgatgct gtttcagaaa gggcaaacgc cattttaaaa caagcgggag aagacaataa 591541 ttcgatcagt gtagtcttta cattagacaa cgctataaag aaagaaacag agaatcagct 591601 ccggataata attgataaaa tcaaaaagat cgacggtgta gaagaggtaa catctcctct 591661 gtcagcggaa aaagaagtca aagaccagtt gatgtcgaaa gacaagaaaa ccgttctcat 591721 gcctgtcacg attacaggtt ctgataaaaa ggcggaaaaa attgcggacg agatttatca 591781 aatcgttcct gatgacttga cggcatatat tacgggagct tcccttatca accaggattt 591841 cgctcacagc tcagaggaag ggcttaagaa aacggaagtg ataacagtct gcctgatcat 591901 cggtttactg ttgatcgtgt tccgatctgt tgtgacgcct tttatcccga ttgtggttgt 591961 cggtttttct tatctgatca gtcaatctat actgggcatc cttgtataca atgttgattt 592021 tcctatctcg acgtttacgc aaaccttctt agttgcgatc ctgttcggca ttggaacaga 592081 ttactgcata ctgcttctta cacggttccg tgaagaattg gcaaacgggc atgataaaaa 592141 agaagcggcg cttatcgctt accgcacagg gggaaaaacc ttatttatca gcggatttgc 592201 ggtattgatc ggattttccg ccttaggatt tgcgaagttt gcgattttcc aatccgcagt 592261 aggggtagca gtcggtgtgg gaattttaat gatcatcctc tacacactgc tgccattatt 592321 tatggtgacg ctgggtgaaa aattattctg gccttctaag aaagtgctgt cacacagtga 592381 taacaaacta tgggcgtttc tcggcagaca ctccgttgcg cgtccgtttc tgttcattgt 592441 catcacggtg gtgattacgc ttccgttcat cttgacctat gatgaccaga tttcattcga 592501 ctcaactgcg gaaatcagca gcgattataa atctataaaa gctctcgagg ccattaagga 592561 tggattcggg gaaggaaaag cgttcccgat caatgttgtc gtaaaaggag acaaagatct 592621 tacaacagct gatacaatcc cctatctagg aaatatcagc aaagcgatcg agaaagttga 592681 tcatgttgac tctgttatga ccattacgca gccgactggt aaaaaaatca aagatttata 592741 tattgataac cagctaggat cggtttcaga cgggctggat aagacggtga aagggattgc 592801 cgatgtccaa agcggattaa cggatataga aaacggactg aatcaaatgg cagggcaaac 592861 cggctcggcc tcaaatggag ggtctggcgg ttcactgggc gatgcggcag atggcttggg 592921 caaaatcaat cagcagctgc agctcgtgag caaacagatt tcccaaaccg gcaataccgc 592981 acagaccgtg cagcagctta cggcaataag cggacagctt ggccagattc aaaccggcct 593041 tgaacaagcg aaccaacagc tctcaggcca gcaggcacaa gccggaacgc tgacagaaag 593101 cctgaaaaag ctgtccgaag gcgtgaaaag cgcaaatgag ggcctgacga aagtctctga 593161 cggtattaca gcttccagtg atatattaga ggacatgagc aaaagtccaa ctgtaagaga 593221 tactggcata ttcattcctg atcaagtaat gaaggacaaa gactttaaga agtcaattga 593281 ccagtattcc tttgcagacg gcaaaggtgt tcaattaagt gtcgttctgg attcaaatcc 593341 gtactcagaa caagctatta cgacaataaa ccaaatcaaa aaagctgtcg caaacgaagt 593401 tgacggcact cctttggaga atgcacagat cgtgtacggc ggggtcacga gtatgaatgc 593461 ggacttaaag gagctatcca caacggactt ctccagaaca atggtgatta tgattatagg 593521 cctgtttatc gtgttaacca ttttgttccg ctcaatgatc atgccgattt atatgatcgc 593581 gtcattgctg ctgacgtact atacgtcgat atccataaca gaattaattt ttgtaaacgg 593641 cttaggaaac gcgggtgtca gctgggcagt gccattcttc agctttgtca tcttgatcgc 593701 gttaggggta gattattcga tcttcttgct ggatcgattt aaggaagagg tgcaccttgg 593761 cattgagcaa ggtgtcgtca ggtcaatgag caaaatggga tctgtcatta ttacagctgc 593821 cattatattg gccggtacgt tcgcggcgat gatgccttca ggtgtcaata cactgatgca 593881 ggtggcaagt gttatcatca tcgggctctt gctttacggc cttgtcatac ttccgctctt 593941 catcccggca atcattgcga cctttggaga aggaaactgg tggccgttcg gcaggaagaa 594001 aggaaaagag taatcgagag aagagtgatg aatggtcatc actctttttt catgactaaa 594061 cgactaactt cagacgtgtt acccaaaaag atcagacgat caaacggcgg ctgtacttaa 594121 aaacaaagag cccggaaaac attcccgggc tctttgtttt atttccattc tgcaattgta 594181 tcaatcggca gacggtagga agcatagcct tcgtctgctg cttttccgat agaaagtagc 594241 ataaccggta cataacgttc tttatctaat ccgaaggttt ccgcgatgtt ttctttatcg 594301 tatccgccga tcgggtttgt atcgtagcca tgcgcgcgtg cagtcagcat cagctgcatg 594361 gaaacaagac ctccgtcaat caggatcgtt tcacggttga cctgtgccgg aagcttttca 594421 aaatgtgcgg tcagcgcggc gatttgtctg tctttgacct cctgcggcat gtaaccaagt 594481 tccacggctt ttgaatagat ttcttctaga tagtctgcgt tgttcatgtc tgcaaataca 594541 gcgatgacag cagatgatgt tgtgacttgt gtttggttaa agcttgcaag cggtgcgagc 594601 ttttcttttc cttccgggct gtcaatgaca agaaaacgcc atggctgcgc gttaacagaa 594661 gatggggcag ttgttgcttc ctctaagatc tctgtcattt cttctttgct gatttttact 594721 gccggatcat agttgcggat agaacggcgg cctttcataa tttccataaa atcgtttgtt 594781 ttgatcatgt tgatacactc ctcttaagct tcgatattat ttatattgtt tcgcatgcgc 594841 gccagcacat caatgagcag gcggcgttct tctgcgctta catttgcgag catttccttc 594901 atgaaacgct ccttttcctt cttagaagac tcaattcgct ctcttccttg gtctgttaac 594961 cgaacaaggg tgatgcggtt gtcctcaggc ttgcgccgcc ttgataccat gcctttggat 595021 tccagctgtt tcaggtgtct ggtaacggct gcgctatcga tatttacttt cttttgaagg 595081 tcgctttgac tgatctcatc tgcatgataa agcaatgtca gcaattccaa acgagattgg 595141 ctgatgcccg tgcatgcctc gaacttcacg ccaatcacct tgttcacgcc ttgcagctga 595201 tataaaatct cggcttcctc tgaacaaaat gacgccaaaa cccatccctt ctttcctgtc 595261 aaaactatta attgatatat caatgattga cacgtcaatt aatatacaac gattgatttc 595321 atcttgcaag ccatttgcac ttttgaacaa cctcccagcg cataaaattc gctaggctag 595381 aacttagcaa aaaaagctgg ccgcttcttc agatgatgct ggtcacgatg attccctgca 595441 tcattcccat ttataggtgt tcggaatatc actttgccgg cccgtgctca agcggctttc 595501 acaggctgaa agttatgata caatatacaa atgtttcaca gcttcaatcc atagttggag 595561 ctgacatcca ttatataagg gactaggttg aagggaaggt ttgataacat gctgcacaat 595621 ccaactggaa aagaacgctt ggcactagcg tttctgctcg gcatgcttgc tatattgggc 595681 ccgcttaata tagatatgta tttgccaagt tttcctgaaa tcgcgaaaga tttatcagca 595741 agtgcttcac ttgttcagtt aagtttaaca gcctgtctgg tcgggcttac gatcggccag 595801 ctgattgtcg ggccggtcag cgatgcgcag ggaagacgaa aaccgctatt aatctgtatt 595861 tttttatttg cgttatcttc tctgttttgt gcactgtcgc ccaatataac aactttagtg 595921 gctgcgcgtt ttttacaagg cttcactgct tctgcagggc ttgtgctgtc tcgcgcaatc 595981 gtccgcgatg tgtttaccgg aagagagctt tctaaatttt tctcgctgtt aatggtcatt 596041 accgcggtgg cgccaatggt tgcgcctatg acaggcggtg ccattttgct tttgccgttc 596101 gcaacgtggc atacaatttt tcacgtctta atgatcatcg gatttttact agttcttctg 596161 attgcattga ggttaaaaga aacgcttccg ctggaaaaac ggattccaag ctcaatcgga 596221 acatccgtca aaacgatggg cagcctgctg aaggatcgat cctttatggg gtacgcgtta 596281 actgtcggat ttattcacgg gggaagcttt gcatatgtgt ctggtacgcc ttttgtatac 596341 caggatatct acggggtgtc tccgcaggta tttagtattc tttttggcat taacgggctg 596401 gcgattatat cgggcagctt tatcatcgga cgctttggcg gaatcattca tgaaaaaagc 596461 ctgcttcgta tagcggtcat tacggctatg attgcgacgg ctgtgctatt aaccatgacc 596521 atgattcacg gtcctcttgc tacattagtc atatccattt tcatttacat gattacgatc 596581 ggcatggttc tgaccagcac gtttacccta gccatggaaa agcaggggca ccgcgccgga 596641 agtgcaagtg cgctgcttgg aatgcttccg ctgctcctcg gttcaatcgt gtcaccgctt 596701 gtaggcatta atgagacaac agccgttccg atgggagcca tcatgtttgt gacagctgtc 596761 atcggctcac tggcgttttt tggattaacg aaagaacgag tagggcagaa ttcataaaaa 596821 aacctgacat gacgtcaggt tttttgtttt atttagaata acaacagcag gcctgcaatc 596881 gccggagtca aaaagatggc tgatttcaaa accacctttg gcatgaggtt ggtgaatttc 596941 gcgcctacat aggccccgca cattgtcccg accagaactt tgacaagtaa aacgtaatca 597001 acaaaacctt ctgtaatata tccgatgcct ccacctacag ccagagggat gatcacaagc 597061 atcgtcgttc cgacagaatg gcgaatggac agattcagca taatcattaa accgatttga 597121 ataaaaggtg ccgacccgat gccgaatgtg ccggaaagaa cgccggctgc aattcctaag 597181 atgaccgctc tcgtatacgt tgaaagagtg ctttgattca cttgagcctt ctcttttaaa 597241 ataaataatc tgattaaaat gagaattgct gataaaaata acattccagc cgtcaaataa 597301 tgaagcaaat cagccggaat aaaagaagtc agcttggcgc cgaaaaatga gccaaccgca 597361 gcaaagcctc cgactattaa gccgattttc atttgaatgt taccctcgcg atagtggctg 597421 tatgcccctg ataagcttgt aaaagccatg ccggcaagcg aagtgcctaa agccgtatga 597481 atcgggatat ggaaaagaag cgttaaaagg gcaatgacaa agccggctcc accggcgcca 597541 ataaagccta aaataattcc tagaagaaac ataacaagaa taatgagcat attttttcct 597601 ccattgaaaa gatgtaaaaa tgtaatcgtg cgctattctg gcggaggtat ggtgtcctat 597661 tgacgaagaa aaacacgccg ttttttcagt tgccagtagt ccgtcgaccg tcgttcagca 597721 aacatatcgt acctcaaatt cagggatctg acaaggcagt ttgttgcttc ccattaccat 597781 ctgttatatg attttgatga agaaaagccc ttgaatatat tcaaaagagg tattatatat 597841 ggacgatttt aaattagata agccgactcc ctactacctg caattttata accagctaaa 597901 aaaaatgatc ttcaacggga cttttaagcc tggggaacgg ataaacgaaa cacagctggc 597961 gaaaagcttt ggcgtcagcc gctctccgat aagggaagcc atgcgattgc ttgagaaaga 598021 tggtttgtta aaagcggatg accgaaatgg gttttcgatc acgtcgttaa cggcaaaaga 598081 tgtagatgag atttataaaa tcagaattcc gctggagcag ctggcagtcg aattagtcat 598141 agacgaagcg gacgaagaag agctgaccat actcgaaaaa cagcttgaag aaacagagaa 598201 agcgattcac aacggcacgg aagatacaga aatcattcgt ttaaaccaaa aatttcatga 598261 gctgctggtt gatttcagcc ataacagaca tttgaaaaat ttgcttgagc atgtaaatga 598321 cctgattcat ttttgcagaa tccttaatta taccggcgac caccgcgcag aaacgatact 598381 gcgtgagcac cgcaggatat ttgaagaagt gaaaaagaaa aacaaagaag cagccaaaca 598441 acatgtgctg gctcatttca atcatgactg tgagcatttg aagcatgtgc ttgaagaagg 598501 taaagagaat tgatttgtat gatccggtac caagggagag cagaaccctt ggtatttttt 598561 tatgtattca ccacatatct aagaggcccc gttaataaga ttttatgatg gtttgactaa 598621 cgaataatgg gggttaaata tgtttatcca tatcgtcggg cctggtgatt ctttgttttc 598681 gataggcaga agatacggtg cttctgttga tcaaatacgg ggtgtgaatg gtttagatga 598741 aacgaatatc gtgccggggc aggctctgct tatccctctt tatgtatata cagtccagcc 598801 gagagatacg cttaccgcca ttgcagctaa agcgtttgtg ccattagagc gactgcgagc 598861 ggccaatccg ggcatcagcc caaatgcttt acaagcggga gcaaaaataa cgattccttc 598921 gatctcaaat tacattgcgg gaacgttaag tttttatgtg ctccgaaacc cagacctcga 598981 tcgggaatta atcaatgatt atgcgccata ctcgtcttcg atttcaattt tcgaatacca 599041 tattgcaccg aacggcgaca ttgcaaacca attgaatgat gcggccgcta ttgagacaac 599101 ttggcaaaga cgagtcacgc cgctggcaac aataacgaac cttacatcag gaggcttcag 599161 tacggagatt gttcaccaag tgctaaacaa tccgacagcg agaaccaatc tggtcaacaa 599221 catttatgac ttagtttcca caaggggata tggcggtgtc acaatcgatt ttgagcaggt 599281 gagcgccgcg gatcgcgatc ttttcactgg atttttacgc cagctgagag atcgacttca 599341 ggcgggaggg tatgtgctga cgatagctgt tcctgcaaaa acaagtgata atatcccatg 599401 gctgaggggc tacgattacg gggggatagg agcggttgtc aattatatgt ttatcatggc 599461 ttatgattgg catcatgcgg gaagtgagcc gggtcctgta gcgccgatta ctgaaataag 599521 gagaaccatt gagtttacga ttgcgcaggt gccgagcaga aaaatcatta tcggagtccc 599581 gctctacggg tacgactgga tcatcccgta ccagccgggc acagttgctt cagcgatttc 599641 aaatcaaaac gcaatcgaaa gagcgatgag gtaccaagcc ccgatacaat attcagccga 599701 atatcaatca ccgtttttcc ggtacagtga tcagcagggg cggacgcatg aggtatggtt 599761 tgaggatgtc agaagcatga gccggaagat gcagatcgtc cgtgaataca gattgcaggc 599821 tattggcgct tggcagttaa cgctgggctt tacgccgggc ccatggcttc tgcggaaatt 599881 ttttacgatc agaaaagtgt aaaaaaagac accagagctt gggtgtcttt tttttgatta 599941 agtccagagc agcagaatag ttcattcatt tgtaccttgc atgggttgtg ttcccatttt 600001 acgattagta gtagtctgat caaacaaaga gtcagaatac gatttgagag ggagttgtct 600061 acatgaagac agtattgatt ttgaattttc ctgcggaagg ccatgtgaat cctactttag 600121 gcattacgaa agcgttttcc gataagggat atgatgtcca ttatatatcc actgaaaaat 600181 ataaaaaacg attagaagca gcgggagcaa cggtccatct tcaccgggat ctgctgcgaa 600241 cgacacctat tcatgtcggt tcgcccaatg gcattcttga tttcgtgaaa atccatatca 600301 aaacgtcatt ggacatttta cagattgtca aagacttatc taagagcatt caatttgatt 600361 ttgtttatta tgataaattc ggcgcggggg aattggtgag ggattactta gatattccag 600421 gggtctcttc atcggcgtct ttcctgtttg gcgaggagca tctgaaaatc ctgccgctgc 600481 atccggagtc tggagcgccg cttgaattgg atcaagagtg cgaagacctt ttggcaaaaa 600541 tgaaagaaac gtacggtgtt gccccgaaaa acctggttca attcatgaac aataaagggg 600601 aattgaacgt agtgtataca agccgttatt ttcagccaga aagtgatcgt ttcggggatg 600661 aatgtctatt tatcgggccg agctttccaa agagagcgga aaaaacagat ttcccgattg 600721 aacagctaaa agatgagaag gtcatttata tttcaatggg gactgtactg gatcatacag 600781 aggatttctt caacctttgt attgatgcat tttcaggctt taacggaaaa gtcgtcatcg 600841 ctgccggaga aaaagcggac ctgaccaaat taaagcaggc gccggaaaac tttatcattg 600901 ctccgtatgt ccctcagctg gaagtgctgg agcaatcgga tgttttcatt acacacggcg 600961 gaatgaacag cgtaaacgaa ggcattcatt tcagcgtgcc actggttgtc atgcctcatg 601021 acaaggatca gccgatggtg gcgcagcgtc tctctgaact ccatgcaggc tatgtcatct 601081 ctaaagatga agtcaatgcc caaatattaa aacaggccgt agatgaggtt ttgcgcaacg 601141 atcagtatac ggcaggcatt aaaaaaatca atcaaagctt caaagaatgt atggacatgg 601201 aagaagtgat ggagcggatt gatgagttga ttcgccaaaa aaacaaataa gaaaaagaac 601261 tcccgtacct tgtacgggag ttcttgattt aaaacttgat tttgattttt tgagcatcac 601321 tgattttctt atggttatgg tcaaagacgt cacttgtcgt gatttcgatc cacttgatct 601381 cttttgtttt cttctcagca tccgcggcct tatcatgagc atggccgctt gatgcgttca 601441 caataaagcc gagatttccg gacttttcgg cgccgccttc caattcgccg tttaactctt 601501 caagataaat atctttgttc caatcaaagg tttcacccgt atttgttttc atcaatgcaa 601561 tcggcgcaac atttactttt tttgtagagg tgttcttgat atcaacgaaa accttaacga 601621 aatcaaactc ttcatcgtgt gttaactcat gaaagtaatc aatcatgctg tagtccgggc 601681 gcaagtggat cagcttcatt tcttttactg ttaactccac gtcgccaatt ttataggttt 601741 tgttcacttg tttgatatct tttaagacag cttttccttt atcatctgaa aacgtttggc 601801 cgaccttatg caatgtccgg tcatcagtta cctgggaatt aggctgataa tcatctgtgc 601861 tgtccttctg ggatgaagtg ctttgcggct cagcttttac tgttttctcc ccgcctgcat 601921 gctgtttttc agtactggcg tttgatgagc agcccgcaag catgatagca aaaacgagaa 601981 ttgaaagaat tcttctcatg atgattcctc cattaaaaag agatcccgtt acttcataca 602041 agcaacggga caccttgtat tcttttactt atcgttaatc ttaatgttgt attgtaaagc 602101 cttgaaaaca tttttggcga tttctgtatt gtcgatttgg ccggcaaatg tctcactaga 602161 cggaccgtat gcatagacgg gaacatcttc accggtatgt ccgcctgttg tccatccagt 602221 gtgagagcgt ttattaaaga tgttctcgat tgcgttatcg atatccagta cttccttcga 602281 ttttgccgct tcttcaacag attgaatttc ggcttttgtt aaagccaatt tcttttgatc 602341 gatatatgtt ttcaacgttt tttcaacatc cgcgccgtca gcgatctttt ctgccataaa 602401 gtctggtgtg cgctttgcgg ctttaatggg ttcactgaac cagttgtaga tgccgtccgc 602461 accgatggaa tatccgccgg ttgagtggtc agccgttgcg acaaccaatg tgtgcttgtc 602521 ttttttagcg aaatcaatag ccgccttata agcttgttcg aagtcttcca tctcgctcat 602581 ggcgccaacg atatcattgt catggcccgc ccagtcaatc tggctgcctt ccaccatgag 602641 gaagaatccg tctttatcct tgtttaattt tttaatggct gtgtttgtca tatctttaag 602701 tgatggaata tccttcgtac ggtcaatctt tttaggcagg ccgccgtcag cgaataggcc 602761 gagaacttgg ctgtctttgt ttttcagcat gtccttgcga tcatccacgt agctgtaccc 602821 cgcctttttg aattccttaa tcaaattacg gtccttacgg tcaaaattgc tctttcctcc 602881 gcctagaagg acatcaattt tgtgcttgcc gttgaccatc tcatcaaaat aatcatccgc 602941 aattgagttc atattttttc ggctgtggtc gtgtgaacca aaagaggccg gagtggcgtg 603001 tgtaatttct gaagtggcca caagtcctgt tgcttttcct ttttctttcg cagcttcaag 603061 caccgttttg gcttctgacc cgtcgttatc aacggctatg gcattattgt atgttttaat 603121 tcccgcagac atagccgttg ccgccgctgc agaatccgtt acattttgtt caggatcatc 603181 ggggtaagtt gtttgctggc cgacaagata ctgatcaaaa gccgtaggct ccacaacttt 603241 tgtcttttta ttatccttta agtatcgata agcagacgta taagacacac ccataccatc 603301 accaatcaga acaataacat ttttaatttc gtcttggttc ccctttttct tttcctgggc 603361 gctggcttca ggcacactgc cgctggctaa gctgctgaac gcaattgatg ataaaaccgc 603421 gataggcagt aatttcttcg ggaatttttt caactggata acctcctaaa tatagatgaa 603481 tctcaatgac aacccaatta tatttttaaa ctgttaagct agtattaatc gattttaaag 603541 attggattta caagaataat gaactggcac ccttaaataa tggttattct tttatgagaa 603601 gttttagaag gaaagagcga tagtactaaa gaaataaatt ggaggaatag atactggccg 603661 tggataggcg gactgaaatc tgctatagtc gcatagaagc aacccgctta catcttgaac 603721 aatttaaagt attacgttgg aaagaggtat tgtgtaagca catgtctgag cagttcatat 603781 ggagtggcat cattttattt taggagggaa caacatggac gttttttctg agtacttagc 603841 ggggattgct gacccgttcc accgagaaag aacggaagag gtgttaactt ggataaaaaa 603901 taaatatcca aatttacata cagaaataaa atggaatcag ccgatgttta cggatcacgg 603961 tacatttatt attggcttta gtgtttctaa aaagcattta gctgtcgctc ctgaaaaagt 604021 aacgatagcg cacgtagagg atgatattgt gaaggccgga tatgattaca ccgagcagct 604081 gatacgtatc ccttggaacg gtccagttga ttatacgcta cttgagaaaa tgattgagtt 604141 taatattctg gacaaggcgg actgctccac tttttggcgg aaatgaagaa aaaggcataa 604201 catatgagct gtataaaata tgttacgcct tttcatttgt ctatttttcg ttttgatcat 604261 ctattgctgc ttttcatcaa acaaggtctt ttcattgagc gtaagctgac tcgcagaata 604321 atgattacct tgtttccatt tcacttcaat cgtaatatca tggccttcaa gctcatgttc 604381 atctaaccgc tctaaaaaag aaacggactt ttcttttgcg cttccatcag aaaaagtgcc 604441 tccagcataa tcatgcatcg ggatttccgt gtcagaactc agcagaactt catcatcctt 604501 ttttacaatc agtgattcca gataagtgtt gtctatttca attgtatcac cgatccaata 604561 aagtttgccg ctgtattcat tcggtgcatc ttcatttttt gtgaaaacag cttcccaatt 604621 ctgatctttg ctttctccct gccaatttgg atactccaaa cgaacatgat gaatcaggtg 604681 ataggaaaaa aagatcaagc agaaagcgat taataggaat gccgtgaaaa tgagagggta 604741 tttataatga ctggacataa aagactccta ttcgtttaat caattacctt cgaaaataga 604801 atttcatccc gaatcaaaat gccgttttca gccacctcgg gaatctccgg cttgagtcgg 604861 cgcgcttttt caactgcgtt cggaaacact gcggcgaatt gatagcctct cttttgataa 604921 aacgctatcg catttacatt atcattcgtt gtgataagct ttattcgttg acaatgtgca 604981 tgtttagcct tctcttcaac ctgctgaagt aaagctgtgc cgattccttt attttcaatc 605041 atactatcta atgaaataat ttcacaatct ttcccatcta ttgtgtatgt aatacagcca 605101 atgatttcgc cgctttcatt tactgcggca aatccatcta attcatcaca ccgaaaaatg 605161 ccgctggaaa tcgccatctc gggtgtaccc caatgcttgg caaaaaaatc ggtcaacata 605221 tgtttcgcta tctcattgtt tgggatgatg atcatcataa cactcctcta ttgaaagatt 605281 gcatatgtac tatcaatata aacaatatat aacaaaaaaa atagatgttg aggtgacggc 605341 atggaaatca gcgatatcat ttacgggcag caccatatag acggagtgct ggaagagctt 605401 atcaaaagcg ctcctgtgca aagattaaaa ggaatctatc aaggcggagc aagcttttta 605461 gtcaatcgaa agtggaatgt gaccaggtat gagcactcca tcggcgtgat gctcctcatc 605521 aaaaagctcg gaggaacgat agaagaacag attgcgggtc tgctccacga cgtatcacac 605581 acagcttttt ctcatgtggt cgacgttgtc tttgaaaatc aagcagaaga ctatcatgaa 605641 aacatctttc aacaagtcat tgttcactct gaaatcccgg acattttaca aaaacacggc 605701 tatcatactg aagaactttt atctgacgat tcaaggtgga cattgctcga acagcccgca 605761 ccggagctgt gtgctgatcg gacagactat acgctgcgtg atatgtaccg atatggacac 605821 attaacctgc acgaagcgca aacctttttg gatcatctta ttgtgagaaa cggaaggatg 605881 tttcctgata gtattgaagc cgccgaatgg tttgtcagtg tgtactacaa ggaagtaatt 605941 gatttctttt tgaatcctgt gaatgtatat ggatatgaat atttagcgcg agcattgaag 606001 gcagcgctgc ggcatgatgt catatctgca gaggatctgc tgaaaacgga ccaagaggta 606061 ctgaacatcc tgcgtgcatc aaaaaatgaa gaagtcctga gcttgcttac atccattcat 606121 cccggcatac aagtaataga ggatgacatc cagtacgatt tccatcaaaa gaagaaaatg 606181 cgcctaatcg atccatccat ttttcttgat gacaaatgga tcaaatcctc aggtgtttct 606241 gaaaaggtga ggaaaatggg tgaggccgct tatcaaaaag caaaaaaagg tgtgtatata 606301 aaaatcttaa agcagtaatt gccgcctgac agcggctttt tttatgtttg gctttgcaaa 606361 caaaggggaa taggacaaac tgcgggaacg ctttatgaga atatcagcgt atttacatac 606421 cgttcggggg tatagtatta tcgagagggc atgttttcat tgtctgcggg caaaagttac 606481 aggaaaaaaa tgaagcaaag gagaatgaac atgaaaatct ctaaatatgc actgggaatt 606541 ctgatgttat ctctagtttt tgttttatca gcatgcggca ataacaacag tacgaaagaa 606601 agcacacatg acaatcattc agactcctca acacatgaag agatggacca ttccggatca 606661 gctgacgttc cagagggatt acaggaatct aaaaatccga aatacaaagt aggcagccaa 606721 gtaatcatca atacttctca tatgaaaggc atgaaaggtg ctgaagctac ggtaacaggc 606781 gcctatgata caacggcgta tgttgtttct tatactccga ctaatggggg acagcgtgtg 606841 gatcatcaca aatgggtgat ccaagaagaa atcaaagatg ccggagataa aacgttacaa 606901 cccggagatc aggtgatttt agaggcttct catatgaaag gcatgaaagg agcaacagcc 606961 gagatcgatt ccgcggaaaa aacaactgta tacatggttg actacacatc gacaacgagc 607021 ggcgaaaaag tgaaaaacca caaatgggtc acagaagatg agctttcagc taaataataa 607081 aaaatcctcc ttttacaagg aggatttttt tgctgtttga acaggtcttg ttaaagaaat 607141 gaaagcaaac aggacagcga tgatcacaat cgatccgccg caccatgccg ttgacaccac 607201 agtacccgtc tgatccaaaa caacaccgcc aatggctgag ccaagggcaa ttccgacttg 607261 gagggccgat gtgttaaagc tttgctgaat gtcagacgaa tcaggtgcaa tttcaattaa 607321 atagctttgc tgagccgggg cgaggctcca gctcagaaga ccccaaatca ccatgacagg 607381 caaaaagaaa atcatagacg atgtagacag cggcagtaag aacataatga tggcaaagga 607441 accggtcacc agcaaaatgc tcttaaagga accaagccgg tcagatagcg ctcctccgaa 607501 agggcctccg catacagcag atatcccgaa aaggaaataa caaatgctga cccagaaaga 607561 gctcaggtga agagtctctt ctaaaaacgg cgcaaagtaa gcgtaaagcg tgtagtggcc 607621 agctaatgta aacatcgtga cgaggtgtga actcgcgatt ttcagattac cgatcgtctt 607681 gagttgttcc cggaaaggaa tcattttctc cgccggtatt ctttcaaaga agattgaaat 607741 aatcagcatg gagatcagtg ccaacaggcc gatgccaagg aacaaaatcc gccacccgaa 607801 ggaatcgctg attaagattc cgagcggcac gcctaatgcg atagcagagc tgaatcccat 607861 aaaaataatt ccgattgcgc gggctctgta ttcaggcgct acaattttcg gggcaattgt 607921 taaagaaagc acaacaatca gccctgtact cattgctgcc aataccctag ataccatcag 607981 tgttgcgaaa ttagggctga aataggcgac aagattgcta aggaagaaaa caaataaagc 608041 aattagatat aagcgcttcc gctcaatctt cgcagtcaat gccaaaagca gcggcccaga 608101 tactgcatat cccagcgcaa acacactgat cagctgtccg gctgaaacaa tggaaatgtc 608161 taaatcattt gcgatctgag gaagaattcc ccccacaatt aactcaacca atccgactgc 608221 aatcgtagaa gctgcaagca ggaaaacttt gaaattcata acaaactcct ttacttaaat 608281 gttttgataa ataaaaaaaa tcctgattac aaaaaatgtc ataaacaaat tttgtaatca 608341 ggattttacg gttcctggta gacaccctca aaccatatta ttgaggttat acaagtgata 608401 atagctattt aattgattcg tttccgttga tgagtgtacc acattatgaa tgaatcttcc 608461 atagaaaaat ttataaaacg gtgaaccgga aaaaaatatg attatattta ttttataaaa 608521 gtatagacat ttaaaattaa atgactataa taatcaatgt aagcgtttta ataacagggg 608581 ggatagcagt tgaaaaaaat attactcgcg tgcagttcag gaatgtctac cagtttattg 608641 gtgacaaaaa tgaaggaata cgcacagtct atcggtgagg aagcggagat ttgggctgtt 608701 ggccaggata aagcaaaaga agacatgaga aaagcggatg ccgttttgat cggtccgcaa 608761 atgagctttc tgaaaagcga gctccaaaaa gaagcagatc aatacaacat tcaagttgaa 608821 gtcattgaca tgatggccta cggaatggca gatgggaaaa aagcgtatga gcaggcattg 608881 tccttaatgg tgaatcaata atggaacaga tgaaaatcac gaatttaaca gacgagcaaa 608941 tcagttttca gctaatcctg cacagcggaa atgcccgcag ctgcatcata caatcactgc 609001 gcgcctataa agaagggaaa aaggacgagg ctgatgccct cattgccaag gcggagcagg 609061 atttatccgc ggcccatgac attcactttc aaatgataca gaaggaatcc ggcggagaag 609121 caacagcttt ttcattgctg cttatgcatg cagaggatca tctgatgtca acattatcca 609181 tgaaagaatt agtgaaagag atgcttgatc tctttaaaac caagaatata taaaaaatcg 609241 gggtggatag ggtgttcgag aaaatcagcc aattccttgt tccaattgca gggaggttaa 609301 acaataaccg ctatttgcaa gtgttgcgtg atgcatttat gctggctttc ccgctgacga 609361 tattcgggtc catttttgtc gtgttaacga atttgccgtt tctaaacaaa atcatgaacg 609421 cctcaatgct tacgtcgttt cagtctcatt tcggcattgc ctccacggcg acaatgggca 609481 ttatgtctgt ctttgttgtg ttcgggatag gctattacct gtcgaaaagc tatcaggtcg 609541 aagctgtatt tggcggagcg atcgctttgg tttccttttt gctcttaacg ccatttatca 609601 ttcagccgga aacaggtgat gccattacag gggttatccc ggtcgatcgt ctcggtgcaa 609661 aagggatgtt tcttgggatg attacggcat ttctttctgg cgaaatttac agaagaatcg 609721 ttcaaaaaaa cctgacaatc aaaatgccag ccggcgttcc gcctgctgta gcaaaatcat 609781 tcgccgcact tattccggct tttatcacat tgactgtatt tttgctgatt aacgtaatgg 609841 tgactctgtt ttttaaaaca aatatgcacg acgtcattta tcatgcgatt caggctccgc 609901 ttgtcggact tggaagcggt atcattccaa cactgattgc cgtgtttttc attcaaattc 609961 tttggttttt cggactgcat ggacagatca ttatcaactc cgtgatggac ccgatttgga 610021 atacactgca ggtagaaaac ctttctgctt acacggcggg aaaagaaatc cctcatatta 610081 tttcaaaacc gtttatggag atttatacag tagggatggg cggaacaggg atgacgcttg 610141 cgattgtgtt taccattctc atattcatga aaagcaggca gatgaagcaa gtatcaaaac 610201 ttggcctcgc tcccggtatt tttaacgtaa acgaaccgat tatctttggg cttccgattg 610261 tcatgaatcc gatcattatt gtgccttggg tgctggcacc gatggttgtt acgctcgtca 610321 cctatctggc tatgtcagcc gggctcgttc cgcctccaac tggtgtgaca gtgccgtgga 610381 cggttccatt attcattaat ggcatcatgg cgacgaactc aatcatgggg ggcgtgatgc 610441 agcttatcaa tctgctgatt gtcttcgtga tctggtttcc gttcctaaaa gcaatggata 610501 aattaaatct ggcaaaagaa aaagaacagg ctgtgcagga gacagctgct cagcaaaatg 610561 ataacagcat aaaaatgtga cataagggga gagagacttg gcacatacag aacaatatcg 610621 ttttccaaag gatttttggt ggggatcatc cgcttcagca acacaaatgg agggtgccgc 610681 cgacagagac ggaaaaggcc agaatatatg ggattattgg tttgaaaaag aaccgcatcg 610741 tttttttgat catgtcggac ccgcagacac atcccaattt tacgacaact ataaagaaga 610801 tatcaggctg atgaaggaac ttggccacaa ctcgttccgg atgtcgattt cctggtcacg 610861 tttaatacca aacggaacgg gcgagatcaa cgataaagcc gcagatttct ataacaatgt 610921 cattgatgag ctgatcgcta acggaattga accttttgtc aatttgtttc atttcgatat 610981 gccgatggcg cttcaaaaaa tcggcggctg ggtcaacaga gagacggttg acgcgtatga 611041 aaactatgca agaacttgct tccgtttgtt tggcggccgg gtgaaaaaat ggttcacgca 611101 taatgaacca atcgttcccg tagaaggcgg atacctatat gattttcatt atccaaacaa 611161 ggtcgatttt aaagaggccg tccaggttgg atttcatacg atgctatcaa gtgcccgcgc 611221 cattcaggct tacagggaga tgaagcagga cggaaaaatc ggcatcatct taaatttgac 611281 cccttcatac ccgagaagca gccatccggc ggatgtgaaa gccggggaaa tcgcagacgc 611341 gttttttaac agatcttttt tagacccatc tgtcaaaggc gaatttccca aagagctggt 611401 tgacattttg aagcatgaag gctttatgcc tgattacaac gctgaagatc tcgacatcat 611461 caaaaagaac acggttgacc tgttgggagt gaattattac cagccgagac gtgtgaaagc 611521 gaaagaacat cttccgaatc ccgacgctcc ttttttgccg gacaggtatt ttgatcccta 611581 cgtcatgccg ggccgcaaaa tgaatccgca tcgcggctgg gagatctatg aaaaaggcgt 611641 ttatgatatt ttgatcaatt taaaagaaaa ctacggcaac atcgagtgtt ttatctctga 611701 aaacggtatg ggggttgaag gtgaagagcg attcagggat gaacaaggca tcattcagga 611761 tgattaccgg attgaattta taaaagagca cctcaaatgg attcaccgcg ccatacagga 611821 aggctcgaac gtaaaaggct atcacttatg gacgttcatg gacaactggt cttggacaaa 611881 tgcctataaa aaccgatacg gatttgtatc agtcaatctt gagaaagacg gagaaagaac 611941 cgtcaaaaag agcggaaaat ggttcaaaga ggttgctgag catagcggtt tctagatttt 612001 cctaaaggtc aagatcttcc ggcaatcatc ataacgaata gagatgacga aaatccgcaa 612061 cattgatgaa atagggaaaa gaacttatga tatccgtaaa agcttatgtg atatcaaaca 612121 gctgccggag gataccaatg aataaatacg aaatcattgc aaatgaaatg agaaatagaa 612181 ttaaaaataa cgtatatccg atcgatcagc ccattcctga tgaagtatct cttgcaaaag 612241 aatttaactc aagccgcatg acgatgaaga gagccttgga taatttagtt gccgagggtc 612301 tgctgtttag aaaacgaggc catggcacgt ttattattca atctgcaata caggatgacc 612361 atgtccatgt agtcagcaat gagattctcg gattgaccaa cttgctgaaa gataaaaaaa 612421 tcaaaagcaa ggtcattcag tttgaagtgc aatttcccac tgaggaagtg gccgcccatt 612481 tgtctattga tcagaaaaca ccggtttatt atgtcgttcg gctgcgaatt gtagaaggtg 612541 aaccctatgt attagaaaaa acatatatgc cgactcattt aataccgggc attaatgacg 612601 atgtccttca tgattcgatc tacaatcata ttacaaatgt gctgcagctc aaaatcgccg 612661 gaacgcatcg gaaaatcaga gcctgcaaat ctgatcatat tgaccagcag catctgggct 612721 gtaaacagga tgatccaatt cttgaagtgg aacatgtggg cttcttagat accgggattc 612781 catttgaata ttccttttca cgtcatcggc atgacaagtt tgttgtgact tctgtaaaca 612841 tacggcgctg attgcggaga caacaaggag gccatctgca tgcttggcgg tattgaagca 612901 ggcggcacaa agtttgtttg tgctgtcggt agagaagatg gaacgatcat tgacaggata 612961 gaattcccca caaagatgcc ggatgaaacg atagagaaag taattcaata ttttagccaa 613021 ttttcattac aggcaatcgg catcggctcc tttggtcccg ttgataacga taaaaccagt 613081 caaacatacg gtaccattac ggccacgccg aaagcgggct ggagacacta tccctttttg 613141 caaaccgtta agaacgaaat gaagatccca gtcggattta gtacagatgt caacgctgcg 613201 gcgctgggtg aattcctttt cggtgaagcg aagggtcttg acagctgcct gtatataacg 613261 attggcactg gcatcggagc gggggctatt gtagagggga ggctccttca ggggctgtca 613321 cacccagaga tgggccatat ttatatccgg aggcacccgg atgacgtata ccaagggaag 613381 tgcccttatc atggagattg ctttgaaggc ttagcttcag gccccgctat cgaagcccgc 613441 tgggggaaaa aagccgcgga tttatcagat atagcacaag tctgggaact ggaagggtac 613501 tatattgccc aagcactggc tcagtatatt ttgatccttg cacctaaaaa aatcattctt 613561 ggcggcggcg tcatgcaaca gaaacaagtg ttttcttata tctatcaata tgtaccaaaa 613621 atcatgaaca gctacttaga tttttctgaa ttatcagatg atataagtga ttatattgta 613681 cctccacgtt taggcagtaa cgccggaatc atcggcacgc tagttttagc gcatcaggcc 613741 ttacaagcag aggcagcatc cggggaggtg cgatcatgac gcatccatta tttttagagc 613801 ctgtctttaa agaaagacta tggggaggga cgaagcttcg tgacgctttt ggctacgcaa 613861 taccctcaca aaaaacaggt gagtgctggg ccgtttctgc acatgcccat ggctcgtcgt 613921 ctgtaaaaaa tggcccgctg gcaggaaaga cacttgatca agtatggaaa gatcatccag 613981 agatattcgg gtttccggat ggtaaggtgt ttccgctgct ggtaaagctg ctggacgcca 614041 atatggatct ctccgtgcaa gtccatcctg atgatgatta tgcaaaactg cacgaaaatg 614101 gcgaccttgg taaaacggag tgctggtata tcattgattg caaagatgac gccgaactaa 614161 ttttgggaca tcatgcaagc acaaaggaag agttcaaaca acgaatagaa agcggtgatt 614221 ggaacgggct gctgaggcga atcaaaatca agccaggaga tttcttttat gtgccaagcg 614281 gtacactcca tgctttatgt aagggaaccc ttgtccttga aatccagcaa aactctgata 614341 caacatatcg cgtatacgat tatgaccgct gtaatgacca gggccaaaaa agaactcttc 614401 atatagaaaa agccatggaa gtcataacga taccgcatat cgataaagtg catacaccgg 614461 aagtaaaaga agttggtaac gctgagatca ttgtttatgt gcaatcagat tatttctcag 614521 tgtacaaatg gaagattagc ggccgagctg cttttccttc atatcaaacc tatttgctgg 614581 ggagtgttct gagcggatca ggacgaatca taaataatgg tattcagtat gaatgcaatg 614641 caggctcaca ctttattctg cctgcgcatt ttggagaatt tacaatagaa ggaacatgtg 614701 aattcatgat atctcatcct taatgaatgg gggagttgca tttgtttaag aaacatacga 614761 tctctttgct cattatattt ttacttgcgt ctgctgtttt agcaaaacca attgaagcgc 614821 atactgtgtc gcctgtgaat cctaatgccc agcagacaac aaaaacagtg atgaactggc 614881 ttgcgcacct gccgaaccga acggaaaaca gagtcctttc cggagcgttc ggaggttaca 614941 gccatgacac attttctatg gctgaggctg atagaatccg aagcgccacc gggcaatcgc 615001 ctgctattta tggctgcgat tatgccagag gatggcttga aacagcaaat attgaagatt 615061 caatagatgt aagctgcaac ggcgatttaa tgtcgtattg gaaaaatggc ggaattccgc 615121 aaatcagttt gcacctggcg aaccctgctt ttcagtcagg gcattttaaa acaccgatta 615181 caaatgatca gtataaaaaa atactagatt cttcaacagt agaaggaaag cggctaaatg 615241 ccatgctcag caaaattgct gacggacttc aagagttgga gaaccaaggt gtgcctgttc 615301 tgttcaggcc gctgcatgaa atgaacggcg aatggttttg gtggggactc acatcatata 615361 accaaaagga taatgaaaga atctctctat ataaacagct ctacaagaaa atctatcatt 615421 atatgaccga cacaagagga cttgatcatt tgatttgggt ttactctccc gacgccaacc 615481 gagattttaa aactgatttt tacccgggcg cgtcttacgt ggatattgtc ggattagatg 615541 cgtattttca agatgcctac tcgatcaatg gatacgatca gctaacagcg cttaataaac 615601 catttgcttt tacagaagtc ggcccgcaaa cagcaaacgg cagcttcgat tacagcctgt 615661 tcatcaatgc aataaaacaa aaatatccta aaaccattta ctttctggca tggaatgatg 615721 aatggagcgc agcagtaaac aagggtgctt cagctttata tcatgacagc tggacactca 615781 acaagggaga aatatggaat ggtgattctt taacgccaat cgttgagtga atccgtaatg 615841 tcacaattaa gaaggtgctc aagaagtttc ttgagcacct tcccactgga ttaagcattc 615901 atatcgccta acccaggact gtgttcattt ggtatttcag gaagcactgg tacgggaaac 615961 cctgccggag gatctattac ttgtaactct ccgccatttc ggcttggaga tttcccttga 616021 tagatttcac tgattctcgt ttcatccaac ctaaagttaa aatgtgtatt atggtagcct 616081 aattcgacat actttctgca ctcaggatat ttattaatgt cataattcgg cacagggagc 616141 agcttcgccc attcaacgcc caatgtctcg agcgctttcg cgaatgcatt ctggtgagca 616201 ttgtcgcgta caatcagaaa agcaagtgtt tcgcggaacg tctgattaga gctcatttca 616261 taaattcttg ttttttgcag cacacctgtc gactcaagaa gcaggttatc cagcaggtca 616321 gtaattaagt ttccgtggtt atacacccac gacccgttcc acggattgcc ccctgcatca 616381 acaggaaggg aactttgcgc tccaataata taatgatgag gattagcatg tttaaccgct 616441 tcatcaagtg gcgcttgatc tgtaccttga ctgccgacac cttcaccgcc tgattcatct 616501 aataaagcat tgattgtgtt ttgaaccagt tcaacgtggg caatctcctc taaaaaaatg 616561 ccgcgaagca gatcgcggta ctgtttctgc tttcctctga aattagagct ttggaaaaaa 616621 actgcatcat tgtacgcatt tctccgtaat gaccgcctaa tatctcctgc aggaccttag 616681 cagctgccgg gtctggcttg tccggtttaa tgatattaat cagttcctct ttgtagtaat 616741 acataacacg cctcatttct tcttaagaga ttttcttata ttatttgtaa gatgagataa 616801 aatatataca tgataagcat gggaaggcgt gaaagaagaa aataaaaaaa tacaggaaaa 616861 gtgttgacca aataaaacag gcatggtata ttattaaacg tcgctgatga acagcgtgaa 616921 acaaaacaga aaaacaaaaa agttttccta aggtgtttac aagattttaa aaatgtgtat 616981 aataagaaaa gtcgaattga aaaagattcg aaaaaacatt aaaaaacttc ttgacttcaa 617041 catcaaatga tagtatgata gttaagtcgc tcaataagcg cccgtagctc aattggatag 617101 agcgtttgac tacggatcaa aaggttaggg gttcgactcc tctcgggcgc gccatataag 617161 ataccacgcg ggtgtagttt agtggtaaaa cctcagcctt ccaagctgat gtcgtgagtt 617221 cgattctcat cacccgctcc attattgaat gatctttgaa aactaaacaa gacaaaacgt 617281 acctgttaat tcagtttttg aaaatcgcac agcgatgtgc gtagtcagtc aaactagggc 617341 ctgcacgatg caggtcacac aggtgtcacc gcgggatgcg gtggacttaa cctgtgatcc 617401 atttatcgga gagtttgatc ctggctcagg acgaacgctg gcggcgtgcc taatacatgc 617461 aagtcgagcg aacagatggg agcttgctcc ctgatgttag cggcggacgg gtgagtaaca 617521 cgtgggtaac ctgcctgtaa gactgggata actccgggaa accggggcta ataccggatg 617581 gttgtttgaa ccgcatggtt caaacataaa aggtggcttc ggctaccact tacagatgga 617641 cccgcggcgc attagctagt tggtgaggta atggctcacc aaggcaacga tgcgtagccg 617701 acctgagagg gtgatcggcc acactgggac tgagacacgg cccagactcc tacgggaggc 617761 agcagtaggg aatcttccgc aatggacgaa agtctgacgg agcaacgccg cgtgagtgat 617821 gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa caagtaccgt tcgaataggg 617881 cggtaccttg acggtaccta accagaaagc cacggctaac tacgtgccag cagccgcggt 617941 aatacgtagg tggcaagcgt tgtccggaat tattgggcgt aaagggctcg caggcggttt 618001 cttaagtctg atgtgaaagc ccccggctca accggggagg gtcattggaa actgggaaac 618061 ttgagtgcag aagaggagag tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg 618121 aggaacacca gtggcgaagg cgactctctg gtctgtaact gacgctgagg agcgaaagcg 618181 tggggagcga acaggattag ataccctggt agtccacgcc gtaaacgatg agtgctaagt 618241 gttagggggt ttccgcccct tagtgctgca gctaacgcat taagcactcc gcctggggag 618301 tacggtcgca agactgaaac tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat 618361 gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc 618421 tagagatagg acgtcccctt cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct 618481 cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca acccttgatc ttagttgcca 618541 gcattcagtt gggcactcta aggtgactgc cggtgacaaa ccggaggaag gtggggatga 618601 cgtcaaatca tcatgcccct tatgacctgg gctacacacg tgctacaatg gacagaacaa 618661 agggcagcga aaccgcgagg ttaagccaat cccacaaatc tgttctcagt tcggatcgca 618721 gtctgcaact cgactgcgtg aagctggaat cgctagtaat cgcggatcag catgccgcgg 618781 tgaatacgtt cccgggcctt gtacacaccg cccgtcacac cacgagagtt tgtaacaccc 618841 gaagtcggtg aggtaacctt ttaggagcca gccgccgaag gtgggacaga tgattggggt 618901 gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg atcacctcct ttctaaggat 618961 attatacgga atataagacc ttgggtctta taaacagaac gttccctgtc ttgtttagtt 619021 ttgaaggatc attccttcga aacgtgttct ttgaaaacta gataacagta gacatcacat 619081 tcaattagta atacaagata tcacatagtg attcttttta acggttaagt tagaaagggc 619141 gcacggtgga tgccttggca ctaggagccg atgaaggacg ggacgaacac cgatatgctt 619201 cggggagctg taagcaagct ttgatccgga gatttccgaa tggggaaacc caccactcgt 619261 aatggagtgg tatccatatc tgaattcata ggatatgaga aggcagaccc ggggaactga 619321 aacatctaag tacccggagg aagagaaagc aaatgcgatt ccctgagtag cggcgagcga 619381 aacgggatta gcccaaacca agaggcttgc ctcttggggt tgtaggacac tctgtacgga 619441 gttacaaagg aacgaggtag atgaagaggt ctggaaaggc ccgccatagg aggtaacagc 619501 cctgtagtca aaacttcgtt ctctcctgag tggatcctga gtacggcgga acacgtgaaa 619561 ttccgtcgga atccgggagg accatctccc aaggctaaat actccctagt gaccgatagt 619621 gaaccagtac cgtgagggaa aggtgaaaag caccccggaa ggggagtgaa agagatcctg 619681 aaaccgtgtg cctacaagta gtcagagccc gttaacgggt gatggcgtgc cttttgtaga 619741 atgaaccggc gagttacgat cccgtgcaag gttaagcaga agatgcggag ccgcagcgaa 619801 agcgagtctg aatagggcgc atgagtacgt ggtcgtagac ccgaaaccag gtgatctacc 619861 catgtccagg gtgaagttca ggtaacactg aatggaggcc cgaacccacg cacgttgaaa 619921 agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc gaacctggag atagctggtt 619981 ctctccgaaa tagctttagg gctagcctca aggtaagagt cttggaggta gagcactgat 620041 tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa ctccgaatgc caatgactta 620101 tccttgggag tcagactgcg agtgataaga tccgtagtcg aaagggaaac agcccagacc 620161 gccagctaag gtcccaaagt atacgttaag tggaaaagga tgtggagttg cttagacaac 620221 caggatgttg gcttagaagc agccaccatt taaagagtgc gtaatagctc actggtcgag 620281 tgactctgcg ccgaaaatgt accggggcta aacgtatcac cgaagctgcg gactgttctt 620341 cgaacagtgg taggagagcg ttctaagggc tgtgaagcca gaccggaagg actggtggag 620401 cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg ggtgagaatc ccctccaccg 620461 aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg ttagtcggga cctaagccga 620521 ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc tgtaccacct cctcaccatt 620581 tgagcaatgg ggggacgcag gaggataggg taagcgcggt attggatatc cgcgtccaag 620641 cagttaggct gggaaatagg caaatccgtt tcccataagg ctgagctgtg atggcgagcg 620701 aaatatagta gcgaagttcc tgattccaca ctgccaagaa aagcctctag cgaggtgaga 620761 ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag aatcctaagg tgatcgagag 620821 aactctcgtt aaggaactcg gcaaaatgac cccgtaactt cgggagaagg ggtgctctgt 620881 tagggtgcaa gcccgagaga gccgcagtga ataggcccag gcgactgttt agcaaaaaca 620941 caggtctctg cgaagccgta aggcgaagta taggggctga cgcctgcccg gtgctggaag 621001 gttaagagga gcgcttagcg taagcgaagg tgcgaattga agccccagta aacggcggcc 621061 gtaactataa cggtcctaag gtagcgaaat tccttgtcgg gtaagttccg acccgcacga 621121 aaggcgcaac gatctgggca ctgtctcaac gagagactcg gtgaaattat agtacctgtg 621181 aagatgcagg ttacccgcga caggacggaa agaccccgtg gagctttact gcagcctgat 621241 attgaatgtt ggtacagctt gtacaggata ggtaggagcc ttggaaaccg gagcgccagc 621301 ttcggtggag gcatcggtgg gatactaccc tggctgtatt gaccttctaa cccgccgccc 621361 ttatcgggcg gggagacagt gtcaggtggg cagtttgact ggggcggtcg cctcctaaaa 621421 ggtaacggag gcgcccaaag gttccctcag aatggttgga aatcattcgc agagtgtaaa 621481 ggcacaaggg agcttgactg cgagacctac aagtcgagca gggacgaaag tcgggcttag 621541 tgatccggtg gttccgcatg gaagggccat cgctcaacgg ataaaagcta ccccggggat 621601 aacaggctta tctcccccaa gagtccacat cgacggggag gtttggcacc tcgatgtcgg 621661 ctcatcgcat cctggggctg tagtcggtcc caagggttgg gctgttcgcc cattaaagcg 621721 gtacgcgagc tgggttcaga acgtcgtgag acagttcggt ccctatccgt cgcgggcgca 621781 ggaaatttga gaggagctgt ccttagtacg agaggaccgg gatggacgca ccgctggtgt 621841 accagttgtt ctgccaaggg catcgctggg tagctatgtg cggacgggat aagtgctgaa 621901 agcatctaag catgaagccc ccctcaagat gagatttccc attccgcaag gaagtaagat 621961 ccctgaaaga tgatcaggtt gataggtctg aggtggaagt gtggcgacac atggagctga 622021 cagatactaa tcgatcgagg acttaaccat atttttgaat gatgtcacac ctgttatcta 622081 gttttgagag aacactctca atttgtttgg tggcgatagc gaagaggtca cacccgttcc 622141 cataccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 622201 gagagtagga cgccgccaag cattactttt atcatcgcgg ggtggagcag ttcggtagct 622261 cgtcgggctc ataacccgaa ggtcgcaggt tcaaatcctg cccccgcaac caaatatatg 622321 gttaaataag gagtgcccta agggtgcaac caaaataatc ctatacaaat atggtccggt 622381 agttcagttg gttagaatgc ctgcctgtca cgcaggaggt cgcgggttcg agtcccgtcc 622441 ggaccgccat taatgtaaac gaaacgatca tgttttcgtt ttttttgtgt tttcttttac 622501 tgtatcttct gcttggtgtc atagccaagc tttctttata tcgggaacat cttggatatt 622561 ccagcaaaat tcgataaact aggaagagca caaataggca taagcagggt tgaaaggagg 622621 ttttggttca tggatgaatt tgatttgata catagcatta ctccgcggac cattcaccat 622681 tcttccgttg atgtaggaat aggtgatgat gcagcgctct acactgcgaa acacggcgtt 622741 caggaaattg tttgtgttga tactatggta gaagacgtgc acttcaaatt acactattcc 622801 tcacctgaag atatcgggta caaggcgtta gccgttaata taagtgatat tgccgcgatg 622861 ggaggcattc ctaagtttta tctggtatca cttgcggtac cttcaaaatg gactgaatct 622921 gaaatcaagg cgatgtatga aggaatgaat gaactggcga aactatatca tatggatctg 622981 attggcggcg atacagtttc taccgctgac aaattagtcg ttacagtcac tgtaatcggt 623041 gaaattgaaa agggacaggc ctgtttgcgc agcttggcaa aaccgaatga tattgtgttt 623101 gtaaccggtg aaatcggttc ttctgcagca gggctttctt tattgctgga agagactaat 623161 cctcaaaact catctgtgga aacggattac tttatccaca ggcataaacg gcctgagcca 623221 agagtaagcg tcggcagatt atgctcgatt tttaaacggg cagctttaaa tgatgttagt 623281 gacggattgg ctagtgaact gaacgagatt gcagaagcca gctgtgtttc aattgaaatt 623341 gttgaaagca tgcttccaat tcattctgat ttgcctaagc ttcatcctaa ctggaaagaa 623401 tgggctttgt ttggcggtga ggattttgag ctgacaggga cggtttcaaa tgaggagtgg 623461 gaagtgttga agcaggagtg cgcagcgctt catcttccca ttacaaagat tggctatgtc 623521 agggaaaaaa caaaatctaa agtgatccta aaaacagatc aaacatcaat gatcttagag 623581 aaaaagggat ataatcattt taaataagac gggtgactcg tgtgaagcaa ttaaaatgga 623641 gaactgtaaa tccagaagaa acaaaagcaa ttgccaagct gacggcagcg tttgctaaac 623701 cgggagacgt cctgacatta gagggcgatt taggtgcagg aaaaacgact tttacgaaag 623761 gttttgcaga agggctggga attacacgta ttgtaaacag tccgactttt acaattataa 623821 aagaatataa cgatggcgta cttcctcttt atcacatgga tgtgtataga atggaagatg 623881 aaagtgaaga tttgggactt gatgaatatt ttcacggaca aggtgtctgt ctcgttgaat 623941 gggctcattt aattgaagaa cagctgccac aggagcgact gcaaattgtc atcaaaagag 624001 ctggtgatga tgagcgggaa attaccttta ctgctgtcgg gaatcggtat gaaatgcttt 624061 gtgaggagtt aagtagacat gacaatatta gcaattgata catcaaatta tacattgggc 624121 attgcgctgc ttcgagaaga cactgttata gcagaataca ttacatattt gaaaaagaac 624181 cactctgtaa gagcgatgcc tgctgttcat tcattgctga atgattgtga tatggcaccg 624241 caggaccttt ctaaaattgt cgttgcaaaa ggccctggtt catacacagg agtaagaata 624301 ggtgtgacgt tggccaaaac acttgcctgg tctttagaca ttccaataag tgctgtatca 624361 agtcttgaga cgcttgcggc aaatggccgg cattttgacg gtctgatcag cccaatcttt 624421 gatgctagac ggggacaggt gtacacaggt ctgtatcaat ataaaaatgg gcttttagag 624481 caagttgttc cagatcaaaa tgtgatgctg gcagattggc tggagatgct aaaagaaaag 624541 gaccgccctg ttttgttttt aggccatgat acttctcttc acaagcagat gatcgaggat 624601 gtgcttggaa caaaaggatt cattggaact gccgcccagc ataacccgcg cccttcagaa 624661 ttggcttttc tcgggaagga aaaggaagca gctgatgttc atgggcttgt cccggattac 624721 ttgcggctgg cagaagctga agcgaaatgg attgaaagtc aaaagtaggg tgataggatg 624781 aaaacaaaag cagcggtcag aaatatgcgg cttgaagata tagatcacgt atacgaaatc 624841 gaagcatcct cctttacgtc tccttggacg aaggattcgt tttatcatga gctgctggaa 624901 aatccgtatg ctcattatct cgtgattgaa aaggacggcc atcttgctgg gtattgcggg 624961 atttggattg tgatggacga tgcccagatt acaaatatag cgataaaacc agagtatcgc 625021 ggccagtctt taggagaaac gctttttcgc tcagctgttg aactgtgcaa agaaaaagac 625081 gcaaggcggc tttcgcttga agtgagggtt tcgaatcatc ctgctcaagg cttatataag 625141 aaattcggga tgcagcccgg cggaataaga aagaactatt atactgataa cggggaagat 625201 gcgttaatta tgtgggtgac gataaatgag tgagcaaaaa gacatgtacg tattaggaat 625261 tgaaacaagc tgtgatgaga ctgctgcagc tattgtgaaa aacgggaaag agatcatttc 625321 aaacgtagta gcctctcaaa ttgaaagcca taagcgcttc ggaggcgttg ttccggaaat 625381 tgcttcaaga catcatgttg aacaaatcac tttggttata gaagaggcgt ttcgcaaagc 625441 tggcatgacg tatagtgata ttgatgcgat tgcagtaaca gaaggtccgg gactggtggg 625501 agcgcttctt atcggagtga atgccgctaa agcattgagc tttgcatata acattccgtt 625561 agtaggcgtt catcatatag ccggtcatat atacgcgaac cgtcttgtag aagacatcgt 625621 gttcccggca ctggcattgg tcgtttcagg aggccataca gaactggttt atatgaagga 625681 acatggatca tttgaagtca ttggggaaac ccttgatgat gcggcaggag aagcctacga 625741 caaagtggcg cggacgatgg gattgccata tccgggtgga ccgcaaattg acaagctagc 625801 tgaaaaaggg aatgacaata ttccgcttcc tcgcgcatgg cttgaagaag gctcttacaa 625861 cttcagcttt agcggattga agtctgcggt gatcaatacg cttcataatg catcccaaaa 625921 agggcaagag attgctccgg aagatttgtc tgccagtttc caaaatagtg tgatcgatgt 625981 cttggtaacc aaaacggcgc gcgcggcaaa ggaatatgat gtcaaacagg tccttttagc 626041 cggaggagta gctgcaaaca gaggcctcag agctgcatta gaaaaggaat ttgcccagca 626101 tgaagggatt acgcttgtca ttcctccatt agctttatgc acggataatg ctgcgatgat 626161 tgctgctgct ggtacaattg cttttgaaaa aggaattcgc ggtgcatatg atatgaatgg 626221 ccagcccggc cttgaattga cttcttatca aagtctcacg agataatagc gtgagacttt 626281 ttatctgttt gttattaaca gacaattcac aatttatcca catatctgtg agtaattata 626341 gagatattga tggataaagg gctgaggtca ctgttaataa agtggataaa ttcagaatat 626401 tttgtggata gtgtgtataa agcgcttact ttgtttattt attaggggat gttctgtgga 626461 taaaaagcac ctctaaaaag aggtgcttga cttttttaat cttcttctgt ggatagttct 626521 tcccattcgg acaaaagaga ttccagctcc tgattaagct tctcattgtc tgcatggata 626581 gcttgtactt tttcatgatc ctgatagact tcagggtcac atagcaattc atcattgcgg 626641 ctgatgttct cctcaatggt ttgaacggtg gtttcaattt cttcaatccg acggagtcgt 626701 tggcgctctt tctttttcca ttctttttct tcctcgtagg aacgtttgga gtcagacttc 626761 actgtagctg gcgttttatc agtttcctct tgctgattca ttttctccaa ttcaagctgc 626821 tctgtttttt tctctgtata ataatcgtaa tctcccagat actcctctat atggcttgaa 626881 gaaagctcca atactcttgt ggcgattctg ttaataaaat atctgtcatg tgagacaaat 626941 aacagtgtgc ctggataatc aatcagcgcg ttttcgagaa cttctttgct gtctaaatcc 627001 agatggttcg tcggttcatc aaggatgaga aagttggctt tttgaagcat cagcttagct 627061 agagccaatc ttgctttttc gcctccgctc agtgaatgaa ctggtttcag cacatcatct 627121 ccggagaata agaaatttcc gagacacgtt ctgatttctt tttctgggag cccggggtac 627181 tcgtcccaca gctcatcaag gacacgttta gaggaagtca actcagcctg ttcctggtca 627241 taatagccga cactgacatt tgagccgtaa gaaattgttc cctgatctgg ttttagggtg 627301 tctattaatg ttttcagcaa tgtcgattta cctattccgt tagggccgac aagcgcagcg 627361 ctttctcctc ttgtgagcat gaatgacact tctgttaaaa gcggcggctg gttttcatag 627421 ctgattgtga gatcctgaac acgaaggact tcatttccgc tctgttttgt aatatcaaaa 627481 tgaaagtttg cggatttttc atcgccaagc ggttttgaca tgacatccat tcgctcaagc 627541 tgctttctgc ggctttgcgc ccttttggtg gtagaggctc tcgccagatt tcgatctacg 627601 aagtcctgca gctttgcaat ctcgtcctgc tgcttttcat acattttcag atctttttca 627661 tactgcgcgg ctttttggtc gagataagcg ctgtagttgc cgtgatactt tttgctttct 627721 gctcttgata cctcgtatac ctggtttact actttgtcca aaaagtagcg gtcatgcgaa 627781 acgatgagaa tggcgcctga atagccttgt aaataatgct caagccaggt aagcgtatca 627841 atatccagat ggtttgtcgg ctcatcaaga atgagcaaat caggctgtgt taatagaagc 627901 ttacctaaag ccagtcttgt tttctggcct ccgctgaggc tttgaacctg tgtagaatcg 627961 tcaaaatggc tgaagccgag accatgcagc acagatctaa catccgcttc atattgataa 628021 ccgcctttat ctttgaattc ctgctgaaga cggtcgtagg ttttcatgat gctttctaat 628081 tcacccgggt cagctgccgc cattttttct tccatagccc gcatttcctt ttccattgct 628141 tttaagtggt caaaaacagt cagcagctct tcttttatgg taagcttaga atccaagcca 628201 gtatgctggg cgagatatcc cattgtaata tctttcggtt taataatttc gcccttttca 628261 tacgaaagct ggcctgcgat aattttaagg agcgtggatt ttccggcgcc atttcttcct 628321 acaatggcga tgcgatcacg atttctgact tccagcttta tattgtttaa aatagtatca 628381 gcaccaaatg atttggacag ctgattaact tgtaagatca tcatattatt tcacctctgc 628441 tataataagt taagtgtagc ttatgaacca gaagtcagca aacaatacat tggccatata 628501 agacatagag aagaaaatag tgtatgatct gtttaaggag cgttttaata tgaatggatt 628561 ttctcatttt aatgaacagg gcagagccca gatggtggat attagcgaaa aatcttcgac 628621 tgtccgtact gcggcggctg tttcaagcgt acacatgaag aatgaagtgt acgagaaaat 628681 acaaagtcac gatatcggca aaggagatgt actggctgtc gcacaggtgg caggcattat 628741 ggccgcaaag caaacgtcga atatcattcc gatgtgccat ccgctttcat tgagcggggt 628801 agatatatcg tttgactgga aaataaaaga agcagaagtt atacttcata taaaagcaca 628861 ggtcaaaacg aaagggagta caggtgtgga aatggaagcg ctcacttctg catcggtgtg 628921 cgctcttacc gtttacgata tgtgcaaggc ccttgataag ggaatggtca tcggccctac 628981 tttcttgctg gagaagacag gcgggaaaaa cggtgacttt aaaagagaac tatccgagta 629041 taatttggag gaccaaaaat gaataaggat caatcaaaaa ttccgcaggc gacggcgaaa 629101 cggctgccgc tttactatcg ctttttaaag aatctgcatg cgtcaggaaa acagcgtgta 629161 tcatccgctg aactcagtga tgccgtaaag gttgattctg ccacgattcg gagggatttt 629221 tcctattttg gagctcttgg caaaaaagga tacggatata atgtggatta tttgctgtct 629281 tttttccgga aaacgcttga tcaggatgag atgacagacg tcatcttgat tggtgtcggg 629341 aacttgggaa cggcatttct tcactataat ttcacaaaaa acaataacac aaaaatttct 629401 atggcttttg atataaatga gagtaaaata ggaactgagg taggcggcgt gcccgtctat 629461 aaccttgatg accttgaaca acacgtaaaa gatgaatcag ttgccattct tacagtgcca 629521 gcagttgccg ctcaatccat tacagacaga ttggtcgcat taggaatcaa gggaatcctt 629581 aattttacgc cggcccgttt gaatgtgccg gaacacattc gaattcatca tatagattta 629641 gcagttgagc ttcagtcact ggtttatttt ttgaagcatt attcagtttt agaggaaatc 629701 gaatagaggg aaaggaggag cccaaatatg ccgatcggtc ctggaagcct tgctgttatc 629761 gcaatcgttg ctctgattat cttcggtccc aaaaagctgc ctgaattggg gaaagcagcg 629821 ggagacacac ttcgtgaatt taaaaacgct actaaaggat taacgagtga tgaagaggaa 629881 aaaaagaaag aagatcagta agttaggatg acacgaatga aagtgaatca aatgtcgctg 629941 ctggagcata ttgctgagct tcgaaaacgg ttgctgattg tagcgctggc gtttgtcgtt 630001 ttctttattg ctggattttt tttagcaaag ccgattattg tgtatctgca agaaacagat 630061 gaagcgaagc agcttacgct taacgcgttt aacctgacag acccgcttta tgtgtttatg 630121 caatttgcgt ttatcatcgg catagtcttg acctcgccgg ttattcttta tcagctttgg 630181 gcttttgtga gcccgggcct ctatgagaaa gagcgcaaag taacgctcag ctacattccg 630241 gtctctattt tgctgttttt agcgggctta tctttttcat attatatttt atttcctttt 630301 gttgttgatt ttatgaagcg gatttctcag gacttgaatg tcaatcaggt gatcggaatt 630361 aatgaatatt ttcattttct tctgcagctg acgattccgt ttggactgct gttccaaatg 630421 ccggtcatcc tcatgttttt gacaaggctc ggaattgtga caccgatgtt cttggcgaaa 630481 atcagaaagt atgcgtattt tacgctgctg gtgatcgcag ccctgattac accgcctgag 630541 cttctgtccc atatgatggt cacagtcccg cttttgattt tatatgaaat cagtatcctt 630601 atatcgaagg ccgcttatcg gaaagcacag aaaagcagtg ctgccgatcg ggacgtgtct 630661 tctgggcaat aataaaaaat ccatttctca tgcgagaaat ggattttctt tatttttggt 630721 tctttttgat tttaaatgaa aaggcgaaca tcttaaaaga aatgctgatg ttgtaagcgg 630781 cgaacaccat cagcaggatg gagtaaaatg accacatgct gcctggcgag cttgcggcaa 630841 gataagtaaa gatgcaccct acggcaaagt agatcattcc ccaaactacc gggtttctca 630901 taaaaataat cctccaataa tcaattgcat ttgtgtgctc tgctgttcaa ggtaattacg 630961 aacaggctca agctgcatga tgacgacgaa tgtattcatc attaaatggg cgaaaatcgg 631021 cacccatatc cgttttgttc tcgcatataa aaaggcaaag gtaaagccca ttgctgtata 631081 tagaaggaga tgcttcaaat cagcgtgaac aataccgaag ataaccgagc tgatcagtcc 631141 tgcgaaaaag aaattcgttt tttcgtacag cgcgccgaaa atgatttttc tgaagatgat 631201 ttcttctaat ataggcccga cgatggaaga aacgataatc atgagcggga ctgcctgaat 631261 gacatccaga atcgcttgtg tattttctga ttctcttccg atgccaaaaa cataatattc 631321 aatagagcct gctattcctt gagagaaaag ggcaatgaaa aaaccggcta tcgcccaaag 631381 gatagaaagt ccgattgagt ccttctgtcc gtttcgcagc gtttctttcg gaacggttct 631441 cagaatgagc agaacaacaa cgagacaggc gataaagctg ataacggacc ataatccttg 631501 tgcatgcagc atattttcat ctgtaggctg tcctccggca taaccgaatt taaataacaa 631561 gggaatcgcg attaatgcgg aaaactgcat gatgatatat gtcaaaataa taaaccaata 631621 ctgttttctc aaatggtatg tactcctttg ttaagtgggt ttcgttcatc tacagctatt 631681 gtaacataat cggtacgggg gtgaaaaagc taacggaaaa gggagcggaa aagaatgatg 631741 taagcgtgaa aaatttttta tcttatcact tgaaattgga agggagattc tttattataa 631801 gaattgtgtt agcactcttt agtgctgagt gctaaaatta catattcata ctattgagga 631861 ggttatttca ttgttaaagc cattaggtga tcgcgttgtc attgaactcg tagaatctga 631921 agaaaaaact gccagcggaa ttgtgttgcc ggattctgca aaagaaaaac cgcaagaagg 631981 caaaatcgtg gcagctggtt caggtcgcgt gttagaaagc ggagagcgcg ttgctttaga 632041 agtaaaagag ggcgaccgca ttatcttctc aaaatacgca ggtactgaag tgaaatacga 632101 aggtactgaa tacttaatct tacgtgaaag cgacatttta gctgttatcg gctaattctt 632161 aaataaacaa tacttaaaac atttgaggag gtcttgtaaa catggcaaaa gaaattaagt 632221 ttagtgaaga agctcgccgc gcaatgcttc gcggtgtcga tgcacttgct gatgctgtta 632281 aagtaacttt aggaccaaaa ggacgcaacg tggttctaga gaaaaaattc ggttctccgt 632341 taatcacaaa tgacggtgta acaatcgcta aagaaatcga gctagaagac gcgtttgaaa 632401 acatgggtgc taagcttgtt gctgaagtag ccagcaaaac aaacgacgtt gccggtgacg 632461 gtacaacaac tgcaacagtt cttgcgcaag caatgatccg tgaaggcctt aaaaacgtaa 632521 cagcaggcgc taaccctgta ggcgtgcgta aagggatgga acaagctgta gcggttgcga 632581 tcgaaaactt aaaagaaatt tctaagccaa tcgaaggcaa agagtctatc gctcaggttg 632641 ctgcgatctc tgctgctgat gaggaagtcg gaagccttat cgctgaagca atggagcgcg 632701 taggaaacga cggcgttatc acaatcgaag agtctaaagg cttcacaact gagcttgaag 632761 ttgttgaagg tatgcaattc gaccgcggat atgcgtctcc ttacatggta actgactctg 632821 ataagatgga agcggttctt gacaatcctt acatcttaat cacagacaaa aaaatcacaa 632881 acattcaaga aatccttcct gtgcttgagc aggttgttca gcaaggcaaa ccattgcttc 632941 tgatcgctga ggatgttgaa ggcgaagcac ttgctacact tgttgtgaac aaacttcgcg 633001 gcacattcaa cgcagtggct gttaaagctc ctggtttcgg tgatcgccgt aaagcaatgc 633061 ttgaagacat cgctgtcctt actggcggag aagtcatcac agaagatctt ggccttgacc 633121 tgaaatctac tcaaatcgct caattgggac gcgcttctaa agttgtcgtt actaaagaaa 633181 acacaacaat cgttgaaggc gctggcgaaa cagacaaaat ttctgcccgt gtgactcaaa 633241 tccgcgctca agtggaagaa acaacttctg aattcgacag agaaaaatta caagagcgtc 633301 ttgctaaact tgctggcggc gtagctgtca tcaaagtcgg cgctgcgact gaaactgagc 633361 tgaaagagcg taaacttcgc atcgaagacg ccttgaactc aactcgcgca gctgttgaag 633421 aaggcatcgt atccggtggt ggtacagcgc ttgtaaacgt atataacaaa gtcgctgcag 633481 ttgaagctga aggcgatgct caaacaggta tcaacatcgt gcttcgcgcg cttgaagagc 633541 caatccgtca aatcgcacac aacgctggcc ttgaaggatc tgtcatcgtt gagcgcctca 633601 aaaacgaaga aatcggcgta ggcttcaacg ctgcaactgg cgaatgggta aacatgatcg 633661 aaaaaggtat cgttgaccca acaaaagtta cacgctcagc tcttcaaaac gctgcgtctg 633721 tagctgcaat gttcttaaca acagaagctg ttgtcgctga caagccagaa gaaaacggtg 633781 gcggcgcagg aatgcctgat atgggcggca tgggcggtat gggtggaatg atgtaataaa 633841 gggatattaa cccttataca tcaatgtttt aaccgtctta aaaaactaga caaagcgtga 633901 ataaaaaaag agaaggtctt tcatcagttt actaaactgt tgggagacct tttctccata 633961 ttagcggtca tatgagcata aatgtccatc gtcgtattta tgtccgaatg accaaattgt 634021 tgctggattt ctttaatgcc tactcctgcc tcaattagta aggaggtatg ggtatgccta 634081 aaagagtggg gggtgacatt ctttttatcc cagctttttt gagcagccgt ttaagtctag 634141 tctcaataac ctttcttaat tgcggatgac catcctcccg ctcaaaaata aatgatgagt 634201 cttgataaat caatctattt ttaagcttaa tttcattttg ataaatttta ttttttttta 634261 gtagattgac atcgtttcat caattcgaac gatatcaaca gatcctgttg ttttaggtgt 634321 tagcaattgg tatttttcaa tttgattgtt aggggtgtat agggtctttg tgacctggct 634381 tatcattgaa atctgtccat tttaaagcaa gaagttcacc aattcttagg tcggtctagg 634441 caagtacggt aaagaccaaa tggtccattt ctagcccgtc agattgagcg agctttagaa 634501 aatgtgtcag cacctctttt tccaatgctt tgttgcttct tgggtaattg aaaatcccca 634561 gttgggttca ttttaataat cccttgagtt ttagcttttc ggaaaatcat acggccgcag 634621 gcatgaatac ctcccaaaca attgtgactg tattgctcgt tcagttctaa cgtgcggtct 634681 tcatacattt ttttgtgttt tgctaatcgg gtattgaccc aatactgcga taaaatgcat 634741 cattttcttt tcactggccc gtacactgct tatttttacc ccactccggt tgtaaatctt 634801 aagccaacct tttgcaaatg ttttgaaggg catatctgac tccttaataa aagtcccgtt 634861 gtcgttttgg agttctacgt gacgggctgc tactggggct tctttctttg ttttaaatct 634921 tcctttggat atttctagac gttttttggt taaagggtca atgcctagta gatatgataa 634981 ctccacgtct taccgcattg cttgagtttt gccatttatt tgtccctaac taattttttt 635041 tcatcaaatt ggtctttaag tgagtttaat aatttttgtt tctctcgact ggtcaataat 635101 tgcccttcat atttcaaaag attggataaa tttgagatgg aatcaatcct gatggattct 635161 aaaagctttg taaatttcta attttatcct ggcctactgt gcaacagacc ttcttaatcg 635221 agcctaattt tccatctatt tgattgggga acaaatggct ttttaacaag aaagaagtcc 635281 aagaatacat tgattggtgg tcaattgagg ttaaaaggaa aaagagggcc tgatatatct 635341 ttcactttcg cctaactagc aaaatttaat aaaacgataa gcgatgtgag gtgaaaatta 635401 tgctaagtga taataatttt gtttccgaaa cactggagaa tgtacagtat ctattgccag 635461 gtgcaaaagt aatcaaattg aggggataca gcagggccca caaagtatac accattgcaa 635521 aatccccggt agaaaagtgg aaggtcgccg caggtttatc cggatcagag atagcaattc 635581 tgattagaaa aggtcattgg attggtgcaa gcattccagc tggcggaatt gtcatcgata 635641 ttgatgattc aaaacaggga gagctagtga aaggtttact agatgcgcaa aactttcatt 635701 gtcattgtat taggacccta atgggtggca gtttattttt aaggataacc aacatgggga 635761 aaagaaaatt aaacaaataa ccaaattttt tactcaaata ggtatcatag tcgatgctgg 635821 gatcgctggg gcaggctata ttgttttccc aacaagtaac actgaggacg atatatagta 635881 actaagagtc ctaatgagtt agatgaaata cctaattatc tgaggcctgt acggaattct 635941 gttaatgtaa aggacaacaa cactggtgaa aaatatgtat tccctgtacc aatcgacaga 636001 gttggtagca gaaatgatac tttaaatttg ctacacattt gaaagcctgg aaggtggaac 636061 catacgaaat tagcaaggcc atggaattga tttataaata ccttctgctg gataaaaaag 636121 atttctcttt ggaggaattt tataaactca ccatatatgc tatcaaatgg aaactggaac 636181 aagctcagtt tccattgtat ttagaatcca caaaaaaatc gcatcaaaat gttattcccc 636241 agccgtttaa gataaaagga aatgtcttat ataaaacggt aatcaagaat agcggggact 636301 ttgaagaata gctcatcatg gcgtgtagga gtgattcacc cttttaagaa actgtctaat 636361 atcgaaagaa acagtgttca ttatgaacta gcctcaaacg ataacggacg cgaaaaaaag 636421 gatatagttc ctgctagtgt tatatcacca agcgggagtt gcttttcatt ggcggataat 636481 gggctagttg agaaggaagg gcaaaaaatg aagctgacag agagacaacg acgcttttgt 636541 gatttcttta cagaaactag aaatacaaca gaggctacgc gtctagccgg aaacaaaggg 636601 aaaaatctca acagagtagc ttctcaaaac ttgtcaaaac tagacattca aactatatag 636661 agcaaagaaa taatcaacta gaagcggagc gcatagcaaa cattattgag gtaaaaatgt 636721 tttggacaat tattatacgc gatggaatag ttcggttaaa gagcgactaa aggcgtctga 636781 gtatattact aaaacaaatg cggccttcaa ggaatagatt gaacatactg gtgaaattaa 636841 aacagggaat gaggaagaag ctaaattcga atgagagtga tctaaggctt ctagaattgt 636901 atatggaggt gtggtaacgt gagcaagctt atatagaagg attaagtgat caagtttagt 636961 gtaatactag gaatgataag gtgttcatta acgcacatta caactaaaaa taccgtaaat 637021 gccctcaaga ggatgatata tccaaagcaa aaaccttcat tctttcatga atttaaagta 637081 ttatataagc tactgaaaaa gttttgtata aaaggtataa tgataaagaa cattcgttct 637141 tgtatggggt actttctctg agaatgaaaa taatgtctta gggtgatata atgacaaatt 637201 ttattttaaa tgaaaataaa cagttatcat tggcaattga agatgagaac atagaaaatt 637261 tttatataga tggtacagat ttagtccgaa agataatccg tagatcaggt tcaggagtta 637321 catcacgggt tccggtcctt agcacccaag atttagaaaa caagaacctt catgaattat 637381 acgatgaatc ttggctccgt atgaaaaaca gacccaatac tgagctcact actgagagta 637441 taaatattgc ggatttattt agtggatgtg gaggtctatc cttaggggtt tgggaggcat 637501 gccgtgccct ggggataaat ccaagatttt cgtttgcttg tgatcttaac gaagctgcct 637561 tatctgtgta cgaaaaaaac ttttctcccg attttagctt gaatgaatcc atcgaaaaac 637621 atattaatgg cgagttaggt gctccattaa ctgttgaaga gcaaagaata aaagataagg 637681 tgaaaaaaat agatttcatt ctagcaggtc ctccttgcca agggcattct gatcttaata 637741 accatactag acgaaaagac cctagaaacg ctttactaat gagagtaagt agagttatag 637801 agttgttcca accttcttca gtattagtgg agaatgtacc aggaattatt catgataaat 637861 ctggttcttt taaagaattt aagaatcatt taaagacaca aggttattac ttcgatgaaa 637921 tcgtactaaa tgctgaaaaa ctaggtgttt cacaagcacg tcgtagatat tttatttttg 637981 cttcaaaaac tcctgtatct tccttaaatc aaataaatga attttattca accaatagta 638041 ggccaattag ttgggcaata tcagatttag tagaaaatgt aggtgatgat atattcaaca 638101 ctgcttccga gcattcattg gaaaacaaaa ggagaataga atatcttttt gaaaataact 638161 tgtttgaatt acctaattca gaaagaccgg attgtcatcg gctaaaacca cattcataca 638221 aatctgtgta tggcagaatg tattgggata gacctgctcc cactataacc agagggtttg 638281 gatcaacagg tcaagggaga tttgttcatt ctttgttaaa gagaacgata actccccatg 638341 aagcagctag gattcagttc ttcccggact tttttaactt tggtgacctt cggaggagac 638401 agtatcaaga cgttatcggt aatgctgtgc cttccaaact atcctattta ttagcattac 638461 atcaattaag ataaaaagat ttgaggttga tatctttgaa agttgttagt ttattctccg 638521 gcataggcgg aatagagctt ggccttcatc agtcaggaca tacaacagaa atattttgtg 638581 aggttgatcc tttggcaaaa gctgttttat caaaaaactt ccctggcgtt aagatagaag 638641 atgatattaa tgaaattaga gagttaccaa gctgtgattt agttgcggca gggtttccat 638701 gccaagattt aagtcaagct ggaggtaaag aagggattga cggatcacgc tccggtttag 638761 ttaagaaact atttgaactt atagaaaaga aagaacatgc aaatcgccct ccatggatac 638821 taattgaaaa tgtcccatat atgttaaggt taaaccgtgg taaagctatg tcatatttaa 638881 catctgtcct ttctgaatta ggttatactt gggcatatcg aactgttgat gctcgttgtt 638941 ttggtttacc gcaacgaaga catagagtta ttttgttagc ctctttattt gaagatccaa 639001 aagatgtgat tttttcacag gatcattcag aaccagattt agatggaaag ccttctgttg 639061 tggatcattc caactattat ggtttttatt ggacggaagg gttaagaggt gtcggctggg 639121 cacgtgaagc agttccacct ataaaatgcg gatcgtctgt aggtatagcc tctccacctg 639181 cagtttggtc tccttacgag gatatagtag ggaccattaa tataagggat gctgagcgcc 639241 tacaaggatt cccggaagat tggacaaata tcactactga aacaggtaag gatataaaag 639301 aaggtgccag atggagattg gtgggaaatg ctgtttcggt aagggtttct aaatggattg 639361 gtgaaaactt aagtcagcca aaagggtcga tatcagattt tgaaggtgaa ttagtgacca 639421 agacttggcc aagtgcagca tgggggtacg gagataaaaa gtataaagtt cccgtatcaa 639481 aatgggttgc aaacacagaa caaatagcta tttcagagtt tttaaatcat ccattaaaac 639541 ctttatctgc tagggcatta aacggttttt taggtagagc agccaggtgt acaaatgtaa 639601 attattcgga tgaatttatt aactcgttag aacgttgtaa ggataggcaa cttcaaaagg 639661 tttaactttt cacattaaag agagcatact aaaaagtatc ggagctggat aaaaccagct 639721 ccgtttttta tctttaattt tttttgcatt attccatctt ttattcgacc agttccataa 639781 actccttttc aattctttgg gggtttcggg tctcggcaag actttcatct accctgaagt 639841 agaatttgat ttttggttct gttcctgaaa gtcgcaggca catccaggga tccgacttca 639901 agaaaacatt taagaacatt tgactgtgga aggcccatga gttcctcagg gccttccaca 639961 gtctctcgat tccggtcaag taatcctcaa cagtggtaac cttgacggaa ccaaagctgg 640021 ccaaattcag aacggaaggc agcgagggtc tgctgaatca gttctgcccc ttcttttccc 640081 tttagtgtta atgagcgcag gccttcctga aagtagccat attcttcaat actaaggaga 640141 gcttcgtata gtgaaatcct tttttcttat agtaagcaca tacctcaact gcaaggacat 640201 ccgtctgaac agcatccttg tctcggacaa agtcgccaat cagatagcca tagctctctt 640261 cgtacccaaa gaggaaatta tgttctcctg tcttgtagta gccattaatc tttctggcaa 640321 tgaacttaaa tcccgttaat acaccgattg tttcgactct gaaagaggtt gcaacttccc 640381 tcccaagctc cgaggtaaca atcgttttaa gaacgatccc attagatgga agtgttcctt 640441 tcttttttat ttgggttaag atatagtgga gcagaagtgg ctcggtttga tttccggtta 640501 aaaccgtata ctcaccattt tcatttttaa cagcaattcc aagcctgtct gcatcgggat 640561 ctgttgcaat taaatatcgg cgtcaatttg ctgccttccc tgatggccag ctcaaacgcg 640621 gcatgttctt cagcatttgg actggtgata gtggaaaaca gagggcaggc tgctcctgtt 640681 cttttcccac cgctacatgc ttgtagttca ttgccgccaa ggccattgca gtagatttgc 640741 tgtaccatga agcggcgtaa atacaacctt gatgtctgtt tcatcttaaa tatttgagtt 640801 ttctgaaata gttcaaggta tgccttgtcc acctctgcgc tatattttga tcaggccctt 640861 tgctaggagg aagctggccg ccatctggcc cataaacttt atatccattg tattcaggcg 640921 ggttatggct cgcagtcaca acaataccgg caaaaccatg aaggtgacgt actgcaaact 640981 taacacggtt gtaggcctta atgactcgaa aacgtatgcg ctggatgcca gtgtcctggc 641041 ggcttccatt ataaaagccg ccaacccagc agaaactttc cttaacgtat agatgtcatc 641101 cggtttgttc cagctccaat ttccccgcgc atgcctcctg ttccatatcc caaattcctt 641161 ataaaaagca tcttccaggt ctttctcatt ccttcctgat ttacccaacc ccgattttag 641221 ctcggtgcaa gttgactaaa ctgtagccat ttttctgttt tgtttttcca gcctatgatt 641281 gacctacaat aaaataacat tattgttcat tataatatag tctagaggtt ttcgaacgac 641341 gactttctga cataaatcga gtgctcttgt ctgattatgt ctagttatag ttggtttttt 641401 ttattttgtc tctaaatttg atgagatcat ggtggcgagg aatttctttt tcgacagccc 641461 caatcagtac caattcgata tttgaattgg tctctcaaac aattccatcc tctttattta 641521 ttatgataca attatattaa ttagaaaata catacatatt agcttgtgtg attttatggg 641581 ggtaaaatca atgactttta taaaaagatt agaggacgct tatgaaactc tattagggaa 641641 ttaccctgcc ggagtatcta gtaccagtac tagtaagtat aacgaaatac gaaagattgt 641701 ttcagaagcc ttcttgatcg gtgaaaatga agtgtatgta acgggaacat caagaaggat 641761 tagcaatttg gacactcggt ttgctcaagg aaatcaacgg aataaacata cccggatggc 641821 agttgctttt atttctatac cttctgtgga cgattcggaa ttagatgaac taattataag 641881 aacgagaaat agtgcaatta caacctcatc taaattctgt aacggggaag aaaggggcac 641941 gatttttgac ggaatattac tttttttagt atttgagggt gaaaccaaag tgtatccgct 642001 agcattctta gttttcgaga acgattttga attaaaggaa aaggctgagg aattgattcc 642061 aggaattgaa ctcaaagaat acccgcgagc taatcaatcc ccagcccagg aaaataacaa 642121 aagcgctaaa aatgaagatg aggaaagtgc aaagagctat gtagtcttcc ttgatattga 642181 ggaagatggt tctattgtgg aatttgtaga agataaagac aaaacctata gaattggtga 642241 tatgatttgg acggcttcac atactaatgg ttcatcagct atcacacgca gactggaagt 642301 aattgaagtc gttgaaaatc ttgtggtgtg taagataaaa cataaatata atgaacctgt 642361 tgataagaat tcactgctta agtttgtaaa tattgaacaa gatttgattt catttctaga 642421 cttacatcca aatgtccaaa atggaagtga gggatttgta tctggggaca ttgttgatga 642481 gaacgctact acatcatcgg atgacttacc ggaagacttt gaaaataact aagcgataaa 642541 ctttaaatag gggaaatgaa ctgatggaaa tatccaaaca aacttcagat ttattattga 642601 gcctagaaaa gaaaaaaggc actttaccaa aattcagcgt tttacgcagt attcctagga 642661 ataggattat ttatggtgca ccaggaacag ggaagagtaa ttatctagaa agggaagtgg 642721 gaaagatctt tggtgataat ccatatgtat tcacccgagt tacttttttc cctggttata 642781 catatggaca atttataggt gcttataaac cggttcctat atataaaaaa ttaagcggtg 642841 aggaagagat atttagttca aactttaggg ataagatgga aaactttgag ccaatgattg 642901 attatcaatt tgttcctggc ccatttatcg atgtattaat taaagctctg aaaaatagat 642961 acactaattt tatattaatt atcgaagaaa ttaatcgtgc caatgcagca agtgtttttg 643021 gtgatatttt tcaattatta gacagaaata aaaacggtga aagtgattat cctgttacat 643081 tcgggccgga cattatgaat tatttagcga gaaacggaat taaagatgaa atgattaagc 643141 taccatccaa tttctttatt tgggcaacta tgaataatgc ggatcagggt gttttaccgc 643201 tcgataccgc ttttaagaga aggtggtcat ttgaatattt agagttggaa aagtatagaa 643261 aggcagtgga ctcttggaag ctgagcctca gatataaagg tcataataaa gtaattatgt 643321 ggaatgattt ccgagacatt attaataagc gtcttaaagg aaaagtacca gaggataagc 643381 tgcttggacc ttttttcctg aaagaaagtg aactgtggaa tcagaatgta tttaaaaata 643441 aactgcttta ttatttgaag gaagatgttt tcaagcataa tccaacgatt gattttttaa 643501 atgctagtac tttctctgag ctaattgaaa aatatgatgg ctcggataac atttttactt 643561 ttgacataga tgattcgtct tttgtgagtg attaactatg gataagtcaa gtaagttctt 643621 ctttgaagat caaaaataca ataaagaaag gattgtacgt gtactcggtg gtaatttagc 643681 tttactcaaa agtaaaggta tattatatga agattctagt ggggatttaa tatttaacta 643741 tgtaggtgtt atatctaatg ggcgcaatgt aatattcatt ttgcctaaat actgtaacag 643801 gcacttagat gaacattcaa agcggacttt gtttaataag ttgctgaaga tttttaaaaa 643861 atattcaggt ttaaataaaa gccgggaatc tgattatttc gtatcggagc tagatagtga 643921 tgaagtctcc gactttatga tagcagatta tttgcttaat gatttctcat tgaatgggta 643981 ttatcaaaaa aaatttactg aatatgaaat tgatggagaa ggaattatag attggagtaa 644041 gacagttaat gaaattaccc cagtattctc aaagggagtt ccatattatt tcagtactta 644101 taatgaagtg gtacaaaaag acgagtatca cttgatagtt aaaattcata aatgggcttt 644161 aagtaaatat tttaatgatt tcggagtcat tttaggtttt acgggactag aatttgataa 644221 atcctgtgat ggtatgaaaa ttttggacta cgctgatttt tttggctcag taataaataa 644281 agaaatcgtg aacacatatg ttgatcgtga cgttaaattg ttaaaggcat tgaaaaccgc 644341 aattgatagg gaagagaatc agttttctaa acgacccact ctttctctgt atggaacaaa 644401 atactttcac agagtatggg aggaagtatg taagaccgta ttttcccatg ttaatgaata 644461 cgtaaaaaag atatcaaggc caaattggat taactttacg gatatagagg ttaataaaga 644521 gaaaaaaaca ctagaacccg atattattaa ggctttcgaa taccgttcaa aagaatactt 644581 tttaatatta gatgctaaat attataatat aaattttgac ggaaaaaagc tggaggggaa 644641 tcctggggtt gaagatataa ctaagcagct gttatatgat aaggcacttg aaaaactgtc 644701 cagaggtaaa acaaaacata atgcttttct gtttccttcc tctaattcaa ccaatacctt 644761 taaagtattt ggttctgttg attttgattt tcttgatata gccgctgtaa ctcttgttta 644821 tatttctgct gaacaagttt ataacttata tcttgaaaat aaaacatttt ccactgatga 644881 cttatttaaa tttgtaagtg aaattaataa gtcaaaaaaa cgacatagcg ttataacttc 644941 aacattgtat ggtaatatgt ttttgtttac aaaaagatta agtgataaaa attagttcta 645001 gaaggttaaa agccgataac ataatacttg tcctcggttt tgtcctccta tagttttaaa 645061 aatatttatc agcattaaat gttaagtcta aaaaacagta ttttgagctg gtttttttaa 645121 tactattttc aactgttatt agtcggaatg aatgggttgc atgatgtaaa accgacaaaa 645181 aactcttgat aaacaggggt ttgtcggcaa cggactttta tttttgatgc ccttttggcc 645241 atttgcaaat tttcaaggct tctcatgagt tcaccgaact tgtgagaagc ttcttttttg 645301 atgtataaat aaacatgtgt agtgtgtaca agcttacatg gcatttcatt tatggaccgc 645361 ttctctctct attgcagaca ggatacccta ttggtatact ctcatacgac acaaaaaaga 645421 cccagttatc taaataagta gtgccaccca ctcttagact gtttccccta gaaaagcact 645481 gtcaaagagg aatcctgtta aatcttgtgc ttctttgctt ttttagctaa aagacgatgt 645541 tttccttgca ataaggaact cgtcttttat gttaaatata aagagcgaca gaataatgac 645601 atctgatccc caaaaattca ctgtcgatgg agttagattc ttccaacagt accttaataa 645661 aatccgtccc gacgctatgg agatagacaa cctaattatc aactctgata ttatcaagga 645721 ggacttaata gtgcatgtct caaaaatgat agatcgtttg gctttatatg atttacacag 645781 aaaaagaagc atagataaac atttttctgc tgcttttaca gtcgatatca atgatagaga 645841 ggaattttac agtgcaaata tagctgatgt ttcaattgat ttgaatgaat ctagtggtgt 645901 ttaattgaat ctcatattct tcagaagaac cattcaatac ttcttgaaca atatttaaag 645961 tattcatcag cttcctctac tgaaacaata tcttcaatga aatcggaaaa gtattctagt 646021 tctgttcttg ttggaagaac tattcttaag tatcctaaag ggtctctttt aaatgaatat 646081 accatgataa atcagtcttt cctttctgtt tattcttagt taatattgat cgtacaattg 646141 agtcgacaag acaggctatt gtagatttac gggcgttcat tcactggata aaagcaaata 646201 aaaaagggcc tgttatcata gtcggagtaa gccttggggg atgggttact aatctaattg 646261 ctaccctgga atcgaaaatt gatgtagtgg tatctatctt ttatgccaat cgcctttctt 646321 attcgatatg gaacacgatc ccaggtaaat acataagaga agaattagaa caaaatggtg 646381 tgacctataa tgagttaata aaatattggg atatcacaga tcctagtcaa gccttgccga 646441 aagttaataa agataacgta ctgctgattt ctgctaaaca tgatcaatat attgacttga 646501 aagatgcaga ttatttatgg gaaagttggg ggagacctac aagatatgtc tacaattgtg 646561 gtcattccgg tattgttctt tgtcgcaaaa agctggcaaa tgatacgctt tcctttatac 646621 gagaaaaact ggtttgatac atttgtagac tttaataaga aacgaaaggc caactgcgac 646681 ttcagttggc ctttcctatt tataataaag aaattgagtg agattgctga cagaactacg 646741 tactactcgt tttctttagt tgcccttgct aatcgttcaa cctctccccg aatcccaatc 646801 gcaggctccc acgaatcaat caaacgaatc gccttctgat tagattccac cgctttcgtt 646861 ttctctcctt tacgatacaa cagctgcgcc attccgtagt gatagtagat cagttcaact 646921 tgattggcgt tatgtttgtc atagagcatt tgctcaaagg cttcttccgc tttttcaaac 646981 tgatcacatt tcacgtaagc gacacccaga ttgaaatagg cttctatcgt tttttcgccg 647041 ccgtatgtgg agctgatttc atttgccgct tcgtataatt gaatggcttc tacatgataa 647101 cctctcgcaa agcttaagtc accgcgaacc aatagaactc tgtgttgaat ggtaggggaa 647161 atcggttgat tttcgatttc gtttaaaatt gtctctgctt tttcctgttg cccgtctttt 647221 aaaaacagcc ttgctttgag tgcatgtccc caaaccttta gatcataggc atcgtgagcg 647281 tctgattgtt caagaatctt cagcccggct tctatttgct gaagcgctcc gtctaaatca 647341 ttgacttcca tcaatgccca gcctgaggtg tcgattcgga agtacgcttc tcgtgtgtgt 647401 tggcctaagt gatgggcggc gtcggccgct ttgcgtccgt attcgattcg caggggcagg 647461 ttgattctgc ttagaaaatg gctaatgcgg gtgatgagtt cgattaggat ttctttttgt 647521 tcagtttcac ttgcccattg gatgaccttt aagatgtttg gccattcttg tttcatttga 647581 tctaagttcc gtcccagcag gtagctccaa tagatagagt tgggctgttc ccgctttaaa 647641 tgggtttcgg cataatcaat ataatagtgc gcccagcgat tgcgggcttc tttttcatat 647701 tcgtgctgtt cggacaagtg ctgttctccg taagcgacaa cggtttggtg cgctaagtat 647761 tgtgtcctgc cttggcttcg ttccggctga atcagcgcat atgaccgcat ttgttccata 647821 gcgtaatgaa aacggcgggc gtctaatccg gctgctgccg ccaggctttt ttcatcaggc 647881 ggcttgctga aaaagcaaag cgtctgccag agctttcgcg tatcttcatt gcatctatcc 647941 caggtgcggc caaagaggaa ttcaaacaat tccagcagtg agtagcctgc ttttccaagc 648001 tcatgaatca gctgctgagc ggggatgtca tcgtctgaca tataggcaat gctgagtgcc 648061 atggctttcg ggtttccggc agtcgctgaa atgaattcgt ttttcaggtc agatgataga 648121 tgtaacagct gctccagctt ttcccgttta cgtgggaggt tgcatgtttg taagcagtga 648181 tgcacttctt gttgaaaaaa ttcgtgggca tctgtttggt caagaccgct tagctgaatg 648241 gctgtcattt ctccgaagct ttcccgataa gtttgcttta cgttttcccg cgctgtaagg 648301 agaactttta cgccttgcgg aaggctggtg ataaattcat gaatgtcacg ttctgcagta 648361 tcaatgctgt caacgatcag caggatcggt ttttctctag tgtaattggc taacgcattg 648421 cggacgacaa accgttttac attgattgat ttatcgattt gttctttgcg tccgagctga 648481 taggcgatcg tatttaaaaa atcgctaaag cttaatcctt tccaatcagc gctgacccag 648541 atgatgctgt tgaatgccgg ccaaactgaa gtatcgtcga cacaggaata ggcggcttca 648601 agagcaattg tggtttttcc catgccggcc cagccggtga ttaaacagac tggtgatgga 648661 gaaagcatcc attgccgtat cgcttccata tcaaagctgc gtccgataaa gcgtccggac 648721 cagcgtgagg gtaaattatg cgtgatgggc tgttctgtaa gcgcattcgt ttcttggccg 648781 ggtctgtcat gaaacagccg ttttactaca ttttcaattt cgccttcact cggagccccg 648841 aataatccgt cttttcgcag tattttcgct tttttcaaac aggatgctgc ccatacaggc 648901 aatgcgggtt tgatgactgg gatagtggtg gcttccagca agtcggtcaa ccactcgata 648961 tccaagtcgg tcttttcgag aatgatccag atcattccga acagttttcc gtcgtcgatt 649021 cttccgggaa tgtagtttgc ccccatctgt ccgatccagc ttttgatcgt gtttggggag 649081 actcccagct ggagtgcgat tttatctatg taagactgtc ctgttttttc attctttttc 649141 cttctgactt tataatcagg atgaagtttt agcgttttga cgccaggtgc cagcatttgt 649201 gcaaattgtt ttcggttttc aagttcagcc ataagcctgc acctcctatt agtactattt 649261 tatcaatcca gcgttttttg tatatgaaaa aataaaagta cagtgccgct gtccttttat 649321 acagcaggaa aggctgttga acgtgttaaa aagcagataa aatgggggca gtaacagaga 649381 aaacaaaaat gtatgcactt acattttatt ttctaaagaa aggaacttgc caaatgactc 649441 acacagtacc tcaaaacatg aaagcggctg ttatgcacaa cacaagagag atcaaaattg 649501 aaacattgcc tgtgcctgat atcaatcatg atgaagtgtt gattaaggtg atggctgtcg 649561 gaatttgcgg atctgatctg cattactata caaatggccg aataggcaac tatgttgtgg 649621 aaaaaccatt tatccttggg catgaatgtg cgggtgaaat tgccgctgtc ggatcatctg 649681 tcgatcaatt caaggtggga gaccgcgtcg ctgtagagcc gggtgttacg tgcggacgct 649741 gtgaggcgtg caaagaagga cgctataatc tttgcccgga tgtacagttt ttggctacac 649801 cgccggtaga cggtgcgttt gtccaatata ttaaaatgcg tcaggacttt gtttttttaa 649861 tcccagactc actttcttat gaagaagctg ctttgatcga gccgttttct gtcggtatcc 649921 atgcggcggc cagaacgaag ctacagcccg gatcaacgat tgcgattatg gggatgggcc 649981 ctgttgggtt aatggctgtt gccgcagcta aagcatttgg ggcaggcaca atcattgtca 650041 ccgacttaga gccgctgcgg ttagaagctg cgaaaaaaat gggagcgact cacattatta 650101 atatacgtga acaggatgca cttgaagaga ttaaaacgat cacgaatgat agaggcgttg 650161 atgttgcttg ggaaacagca gggaatccag cggcattgca atccgcactg gcttctgtgc 650221 gccggggcgg aaaattggcg attgtcggtt tgccttcaca gaacgagatt ccgctcaacg 650281 tgccgtttat tgcggataat gagattgata tttacgggat cttccgttat gccaatacgt 650341 atccaaaggg aatcgaattt cttgcttcag gcattgtgga cacgaagcat ctagtaacgg 650401 accaatattc gctggagcag acgcaagatg cgatggagcg ggcgcttcaa tttaagaatg 650461 aatgtttaaa agtgatggtg tatccaaatc gctgagtgaa cagggaggat cttcgtattc 650521 tccctcttgt ttactggaaa tgaaaacgga ttcttggggt gggaaatgat gattggaaca 650581 gaaaaagtaa cggcattgaa ggcgaagcat cagtcaaaat ccagcaccgg cctgtcctgg 650641 tttgaacgaa tcggttatgg attcggcgat atgtcgtata atattatctt tcagtttgta 650701 aacgcatact tattatttta ttatacagac gtcggcggca ttcagcctgc ggtaatcgca 650761 actttgtttc ttgttgtgcg tgtgctggat gctatttttg acccgatcat gggattgatt 650821 ttagataaaa cgaatacaag gtggggaaaa gcaaggccat atttgctgtg ggtggcattt 650881 ccttttgcgc tattcacatt cttatgtttc acgacgcctc atttcggtga gaccggaaat 650941 atggtatatg cgtatgtcac ttatattctg cttgggatgt cctttagtat gcaaacgatc 651001 ccggtgaaca gcttaacggg gcggatgacg aattcggtgg aggaacgaac ggttctgacc 651061 acaacccgga tgattttggt gtatatcggc attcttttat ccatttcctg tgcgacaccg 651121 cttgcaactg ctatcggagg agaggatcag gcgtttggat ttcagatgac ggcgctcatc 651181 tatgcggctg tcagcatcgt tttgaatcta tttagtttct ttactgtacg ggagcggatt 651241 cagcctaaaa agagaaaaaa acaagggatc aaaaagacgt tatccgtttt attcaaaaac 651301 aaacccttgc tcatgttaat ttcatcattt ttggcttttg cgatcgggtt taatattaag 651361 ctcagcacga tggtgtatta ttttacgtat aacgtaaacc ataaagagtt cgtgtttatg 651421 ggcaccgttt tatttttcgg ggcagcgctg atcagcaatt tgtttattcc tttcttttct 651481 gagaagtggg gcagaaaaca agtcatgatt atcacggcag ctctatcgct tatttcttat 651541 gccggcctgc attttacgcc gtattcttca attccactca ttttcatttg gcttttcgct 651601 tcgggatttt tcacaacgcc tttaaatacg cttgcttggg gaatggttgc ggattgcgtc 651661 gattatgcgg aatggaaaac cggaattcgc gcggatggtg ttgtgatttc gagcatgagc 651721 tttattaata agctgggtgt tgcgttagcc gggtcatttt cggccattta tttaggaatc 651781 gccgggtatg tggcgaatac agaccagaca gttgcgtcgt tgaatgcgat taaaaatatg 651841 aatgctttga ttccgggatt tttcattttg ctttctatta ttcttatcgc cttctatcct 651901 ttaacggaaa aaagatataa acacatcatc tctgagctgg agcaaaggtc tgcgagataa 651961 atagatgtaa aatttttaat attcaatgtt gtatttatgg caaaaagtaa tatactgaga 652021 ctgtaatcta gactttataa atgagtgtga taatatgcgt agtcattctg tagtttgtat 652081 tggggaattg ttgattgatt tcttttgtac cgatgttgac gttgatttaa tggaagggcg 652141 ccaattcctg aaaagtgccg gcggggcacc ggcgaatgtg tcggcagcga ttgccaagct 652201 gggcggagac gccgctttca gcggaaaagt aggaaaggat ccgtttgggt attttctgaa 652261 gcgaacattg gacgctgtac atgtcgatac ctctatgctg gtgatggatg agaaagcgcc 652321 tacaacgctt gcttttgttt cattaaaaca aaatggagag cgtgactttg tttttaatag 652381 aggcgcggac gctttgttta cgctggagga cattgaccag gaaaaactaa acgaagcgaa 652441 aatccttcat ttcggctctg cgacggcact gttatcggat ccgttttgct cagcctattt 652501 acggttgatg tcgattgcga aagacaatgg acagtttatt tcgtttgacc ctaactaccg 652561 tgaagattta tggaggggaa gagtctcaga gtttgtaagt gttgcgaaaa aagcgatcgc 652621 tgtaagtgat tttgtgaaag tcagtgacga ggaacttgag attatcagcg gtgtgaagga 652681 tcatgaaaag ggagttgcga tccttcatga gatcggagcc aacattgtcg ctgtgacact 652741 tgggaaaagc ggaacgcttc tttccaatgg aaaagaccgt gaaatcattc caagcattcc 652801 ggtgacatca attgactcaa caggggcggg agatgctttt gtcggtgcgg ctttatatca 652861 attggcaaac acggatcaga ttcaatctgt agatgctgat tttgtgaaac tgcgtgagat 652921 tgtggcgttt gccaataagg tcggagctct tgtgtgcact aaaattggag cgattgatgc 652981 actgccgagt ttggatgaga ttggagtttc tttgtaaatc attgaagatg tttcttgaaa 653041 gtctttggac ttttgggggc atcttttttt attgcttaca tttttgttca ggtaaaaagt 653101 tgtatatttt ttgtttgaaa tgtcattttt tattaaaaaa gtgaaacttt taacgataat 653161 aaatagtata tgtaacaagg gttaccgaat tagctttagg aggaacgata taatgagtat 653221 aattggaaga tttaaagata ttatgtctgc gaatatcaat gctttattgg acaaggctga 653281 aaatccggag aaaatggtag atcaatattt aagaaatatg aatagcgatt tggctaaggt 653341 taaggcagaa acagcagctg ttatggctga ggagcagaga gcaaaaagag aatatcacga 653401 atgccaggcg gatatggaaa agatggaaag ctatgcaatg aaggcgctgc aagccgggaa 653461 tgagagcgat gcgagaaaat ttcttgaaag aaaaacatct ttggagtcaa agctttctga 653521 gctgcaggcg gcgaatcaaa ttgctgcaac caatgccgca cagatgagaa agatgcatga 653581 caaattggta tctgacattg gagagctgga agcacgcaaa aatatgatca aggcgaagtg 653641 ggcagtagcg aaaacgcaag aaagaatgaa caaactgggc gcttctgttt caagtacaag 653701 ccaatcaatg tctgcattcg gccgaatgga ggacaaagta aataaggcac ttgatcaggc 653761 caatgcaatg gctgaactga acagcgctcc gcaggatgat atggctgatc tgtctgcaaa 653821 gtatgacact ggcggttcaa gccaggttga tgatgaactt gcggcgttaa aagcgaaaat 653881 gatgctcgat aagtaataca taggaggccg cagctttcgg ctgcggcgtc attttatcat 653941 aaaatgtgag agggaacggt aatgataata tcttataagt gtccgaactg cggcagtgat 654001 atggcatttg acagtgaaac cggctcgtta tcctgcagca gctgcggaag acaggacaat 654061 attgaaagcc ttccgaaaga aaacattgcg gcacggtttt ctgatgatga agcaaaagaa 654121 tatcaatgta aaaactgcgg tgccgttttg atcacggaag ctgaaacgac agcaacgacg 654181 tgcagcttct gcggaggtgc tgcaatactt gccgatcgtt tatcaggaca tttggcgccg 654241 gcgaaggtca ttccatttac aatcagcaag caagaagcgg agcaggcatt tcgaaagtgg 654301 tgcaaaaaag gccttctgac accaagaggt ttcatgtctg ctgatcgtat caaaagcatc 654361 accggcatgt atattccatt ttggatgttt gatttaaata gtgaagtaca ggtgagagca 654421 aactgtacca gagtccatca atatgaagaa ggggattata tttgcacgga aacagagcac 654481 tttgaagcgt ttcgtgatat caatctcgat tatttgaaaa tccctgtcga tgcctctgaa 654541 aaaatgaaag acgaattaat ggacaaattg gagccttatt catacgaaga gctgaaggac 654601 tttcaaacgg catatttggc cggttatatt gcggaaaagt acaattatac cgatgaggag 654661 ctttttccga gggcaaaaga gaaaatcagc agttatatag attcatacat ccattctact 654721 ttttccggat atacgtcagt caatgtgagg gacaaacata ttcacacgaa aaacgtgaac 654781 agcttttacg ttttgcttcc tgtttggatg gtcagttacg attatgaaag agcggagcat 654841 atctttgcga tgaacgggca aacaggaaag gtcgttggaa agccgccgat cagtcgagga 654901 aaagtggctg catggtttag cggaatagca ggcgggacat ttcttgcgtt gaagctcgtc 654961 tcattgatga tgggaggcgg attttgatgc gtggattttt tgggaaagcg atctttgttg 655021 tgctggctgt tttcatcatg atgcctttac tgggtatcga agcggtaaga gcctctgaat 655081 tgcagcagca tgtgtacgat cgcgctcatc tattgtcaaa agcggagatc ggaaaacttg 655141 aatctctctc ggcaaagctg ggtgcaaaga gggacactga tttcatcatt attacgacca 655201 aaagcacaaa cggtgaagat attgcagact ataccggcga tttttatgat cgttacggaa 655261 aaggcagtac agccattctg acgattgata tgacaaacag agaagtgttt atcgcaggct 655321 ttaaaaaagc cgaacagtat ttggacaaca gcaggctcaa tagcatcaga aatacgattt 655381 catctgattt atccaatgaa aattattttg aagcttttga gacatatatt cagctttcct 655441 ataaagatat gggcataaaa ccgggagtaa accctgacaa catattcttt acatggtggt 655501 ttcagctgat tgctgccatc gcagtcgggg gaattgcggt ttcaatcatg ctttatcatg 655561 caggcggcaa agtaacggtt aatggaagta catatatgga tcagcgtacg tctgatgtga 655621 ttgatcaata cgacacttat attagaacga ctgtaacaag agaaagaaaa ccatcagata 655681 aagacagcgg cagcgatggc ggtgttacga aaggcggcac gtcatacagt gggagccggg 655741 gcagttttta aatgtaagaa atagagaaag ggagaggcgt aatgtcgttt ttcagaaatc 655801 aattagcgaa tgtagtagag tgggaagaat ttagagatga tatgattttt tataaatgga 655861 acaatcgtga aatcaaaaaa gggagccgtt taatcattcg tcccggacag gatgctgtct 655921 ttttgaacaa tgggcgggtt gaaggagtct ttcaagatga tggcgattat gatattgaat 655981 cagaaattat tccattcctt tcaacgttaa agggctttaa gtttggcttt aacagcggca 656041 tgcgagctga ggtgctgttt gtcaatacga aggaatttac cgtaagatgg ggaacaaaac 656101 aggcgataaa tattccggca gcgggaatgc caggcgggat gcccattcgc gcaaacggca 656161 catttaattt caaggtgcag gactatatca gcctgattga taaaatcgct ggcgtgaaag 656221 atcaatattt tgtagaggat attaaaaccc gtatcatttc tattctggat cagcttctca 656281 tgaagtggat cacaagagaa gggaaagata tgtttaatct tcaagcaaac gcttttgata 656341 ttgccaaggg aattcaagag gacttagata tgcaattaat aagcgacggg atgacggtca 656401 ctggttttca aatcatgagc tttaattatc ctcaagaggt tcaagatatg attacaaaga 656461 acgcttccta cggtatggtt ggggatgtga acagatacca gcaaatatca atgacggatg 656521 gaatggcatc cggaaagatg agcggaagcg gagcggcttc ggatatggct ggaatgatga 656581 tgggaatgaa tatggccaat cagatgatga accaaatgaa tcagaatcag caggcacagt 656641 catcaggccc acagtcaact ggcagcggaa gcaaaccgaa tttctgtcca aactgcggaa 656701 caaaaacggg cgaagccaat ttttgtccga attgcggcca gaagcttgta taagaatcat 656761 acagtgaaaa gtccggagtg atcagcactc gggacttttt tatttaggag aataagcatt 656821 acctattgct tgctcctgaa caggccattt tcgagccccc gcttggataa ttcccagcag 656881 caattgacga cgttccttta ttgaattgac ggcaatttga aatgtttgct ttgataaagc 656941 cggtatgcct gattgttgaa gctttgagat gtctggttct ggcggcgctt gttctgcagg 657001 atggatatag gcagtatgaa cggtatccag atagtttttg atacttgagc gcgcttcttt 657061 gatatgaagc tgattcggct gatattgttc aggaattccg tatttgaaaa tggttagagc 657121 ctcatccaat acagcaacag ctataatgga tgattcctga tgctgcgtgc tgtggtaaaa 657181 atgaaggatg gggaaggcgt tatgctgagc ggtcagcttt cccagttctg atgaggcagc 657241 gacaagaaga aaatcaatgt cgtgaaaatc tttgccattc catgcattat ggacgatttc 657301 agttccgtca tgccctagac ttaatacact ttgggcaaag gagcgttttt gattaaccgc 657361 actcaagacg gaaatcaaat acgtgacaga aaatgtgatg gtaagcagtc cttgagctgt 657421 ttcaataatc gtgacaagct tccataggcc tccgttcgga gcgaggtcgc catttcctaa 657481 tgtaaacatg acatagccgg aaaaataaat tcggtctgac caggaagccg gttcttttga 657541 ttgagtttcc ataagtgagt gagggtcact cgagtaaatc aaaacccacc cgctccaaaa 657601 tagactgatc catatcacta acgtcaggca taacagcaga ggaccagcca tacttagaac 657661 ctttgcgtgg tcaccgctga ttttgcggca gcccttccac agccaggcag acaggcatct 657721 tgtgatcggg ccggcaccgc tctctaacca taacgtggtc cataaaaaat caatcatccc 657781 cgctgtcaat aataaaaggc ctgcaatgat ataaccctca ttcattttgg ttgcctccct 657841 taagtcagcc ttcttttatt ttcttctcta tttcctttta tcctgagtct gaaacaattg 657901 aacgaatgtt tgattttaca gagaaaaata ggtgggagtt acccaacact tactcatttt 657961 tcaatatgaa cagaaaatca caagattttt gacttgattc acacattttc atgaagaaaa 658021 acgttcattt tccccttgaa ttggtgattt tccttttata gagtaaaaaa ttttcagaaa 658081 tttatattga ctgaaagcgt ttttataatt atgataatat cagatataac aaaaatgtca 658141 ctataacatc actacaattg aactattaag tgactaataa ataccaaatg aacgaggtta 658201 tgcacaaaga aatgaccatt gttcttttaa cgagaaatga aatcgcttcc atagggattg 658261 acatgctaag aagaagggaa ggttatgagg ttattggata aaaacatgaa caactatttt 658321 ctgaagcctg cttacgaaat gtgaggaagg cagcagccct ggaataagtt tttgacatac 658381 gcattttgaa aaagactggg ggaaacagta tgaataaaca aggaaatcaa atgtcatttt 658441 tacgtacaat tattttagtc tccactttcg gcgggcttct ttttggctat gataccggtg 658501 tgctcaatgg agctttgccg tatatgggag agccggatca gcttaatctc aatgccttca 658561 cagaaggcct tgtcaccagt tcacttcttt ttggagcggc actgggtgct gtgtttggcg 658621 gcaggatgtc tgattttaac ggccgccgca aaaatatttt gttcctcgct gttatatttt 658681 ttatttcaac gattgggtgt acgtttgcac caaatgttac ggtcatgatt atttcccgtt 658741 ttgtgctcgg tattgcggtt gggggtgcat ccgtaacggt gcctgcctat ttagcagaga 658801 tgtctcctgt ggaaagcagg ggacggatgg tgacgcagaa cgaattgatg attgtatcag 658861 gacagctttt ggcctttgtt tttaatgcga tccttggaac aacaatggga gacaactccc 658921 atgtgtggag gtttatgctg gtcattgcgt cacttccagc cttgttcctg tttttcggca 658981 tgatcagaat gcccgagagt ccccgttggc ttgtttctaa aggaagaaaa gaagatgctt 659041 tgcgtgtatt gaaaaaaatc agggacgaaa aacgggcagc agctgagctg caagaaattg 659101 aattcgcttt caaaaaagaa gaccagcttg aaaaagcgac atttaaagat ctttcagtcc 659161 catgggtgcg ccgtattgtg tttattggat tagggattgc gattgtacag caaattacag 659221 gtgtgaattc gattatgtat tatgggactg aaattctaag aaattccggt ttccaaacgg 659281 aagccgcttt aatcggaaat attgcgaatg gcgtgatttc ggtattggca acattcgtcg 659341 gaatctggct gctgggaaga gtggggcgcc ggccgatgct gatgacaggc ttgatcggta 659401 cgacaacagc attattgcta atcgggatat tctcacttgt acttgaagga tcaccggcac 659461 ttccgtatgt agtcctgtca ttaacggtca catttcttgc ttttcagcag ggcgccattt 659521 caccagtgac ttggctgatg ctatctgaaa ttttcccgct tcgccttcgc ggactgggaa 659581 tgggtgttac ggtattctgt ctgtggatgg tgaattttgc agtcagtttc acgtttccga 659641 tattgctggc agctatcggg ctgtccacaa cgttctttat cttcgttgga ttaggaattt 659701 gctctgtctt gtttgtgaag aggtttttgc cggaaacgaa agggctttcg cttgagcagc 659761 tggaggaaaa cttccgcgct tatgatcaca gcggggcaaa gaaggattct ggggctgaag 659821 tgattggata atttaaaaaa gaatccgcac ccgagtgcgg attctttttg gtttcaaatt 659881 agttaggtct aacaaggatt ttgacttggc ttttctcttt aataagagcc ccgaagcctt 659941 cctcgatcaa atcatctagt acgatttttt tcgttacgag tttgtcggct gagaaatagc 660001 cttctttcat taatgacaat acagccggga agatgtcgcg gtatccgata attcctttta 660061 ctgtacgttc tttgattacg atatcgttcg gatggatttc agcacctttt tcccaaatgc 660121 tgacgatgac ggtttcaccg gcaattgtag tggactggat ggcttgtcgt aacaccactg 660181 ggacaccagt gacttcgaat gctacgtcaa caccgcctcc tgtacgttct gcaatctcag 660241 cgactacatc gtctgtttta gacggatcaa cgatgatcgc gccaagctcc tcagcttttt 660301 gctggcgttc aggagaaagc tcaacagcgt aaatatcagt tgcaccggca gccttcagcg 660361 cttcaatgac aagaagtccg atcgggccgc agccgaatac agccgctttg tcgcctgctt 660421 tgagtttgct tgagcggaca gcgtatagag caactgcaga aggttcaacg agcgcgcctt 660481 gttcatatga taattcatca ggaagtttga acaaaagctc ttcatccaca gagacgtatt 660541 cagagaaacc gccgcctccg ccggctaagc cgaggaatcc catttgttca tcaaggttgt 660601 aggcgccttg gtggccgtgt gtagcaaaaa tcggctcgac tacaacgcgg tctccaactt 660661 tataattttc aacgccttct ccgacttcga caacttcacc ggagaattca tgccccattg 660721 tgacaggtgc cgtttcattt gttaatgggt gcggtttgtc aaccggaata aagatcgggc 660781 cgcccagata ttcgtgtaaa tcacttccgc agatgccgca ccatttgact ttgatcttta 660841 cttttcccgg ctccgttttt ggctcttcga tatgttcaat acggatatcc ttttggttat 660901 gccatcttgc tgccttcatg gattaccact cctataactt ttgatgtgag taattccgca 660961 ccggtcaata tgaactgttc acaaaatcgc catttttaaa accaaaaaag aaatgaaatt 661021 tttatataat ataatctacg tttttttgaa aaaaagaaac tttaaagaaa aaagggtctc 661081 gcacactctt ttttctttat atgagagtat caatcgttta catagctatg aatttggttt 661141 gaacaatacg gtaatggttc gttcatattg aatgcgacaa ctactctatc aataattata 661201 actctaatac tgctattata ataggataat cttccatggt ttattttagc agaggtaact 661261 tttttgactt tgtaacatta ctgtaaggat attgaaataa aaaatagctg gttgatcgtg 661321 tataatcttc ctagatgtta acaaacaggg ggacgaaatg ttgaagaaag tcattttagc 661381 cgcttttatc ttagtaggaa gtactttggg agcttttagt ttttcatcag atgccagtgc 661441 gaaacatgtg aacggaaata ttacttggta taatggagtc gggaaaaaag gctcttcagg 661501 taagaaactt ggacattggg attgtgcgac caaaatcgga tttgatgttc ctagaaacgg 661561 gacaaaaatc agagcttatg caaaagcgaa gcctaaaaag gtgattacgg tttataaaaa 661621 tgatgttggc agaatgccta atgcagtgct ggatgttagc cctaaagcgt ttaaagcgct 661681 tggataccca ttaagcaaag gtaaagtagc ggggcattac agctattaat gtacatatat 661741 aatctggaaa gcaagaagtc acattcttgc tttttctatt ggtggagata aaagatgaaa 661801 aaaagaatca tattattatt agcagtgata atagcggcag ctgccgcggg ggttgcgttt 661861 tatgttgcaa aggataaagg ccatgagaag gctgctgatg tttcagtcaa taccgaaagc 661921 ggtgatgagc tgctggtttc aattacagat acggatctgc tgacaaagta ttatgaaaat 661981 gacaaggtga tccatgagga gaagctgacc agctatccgg catttgcctt ggatcaaaaa 662041 cagcaggtgc tctattatac gggcaataat gaacagaatg aaatgaggct ttttaaattg 662101 gatctgaagt ctcataaaaa aacgatgctt tataaaggcg cggagagtgc ggacagttta 662161 tttttatcaa aggaccgttc aaccatctat ttccgcttag gaaaagcgga cgaaagcaat 662221 tttcgaatcg ccgcttttga tctgaagacg aaaaagtata aaaatcttta tcctgccgct 662281 aatgatcagg atgacaccgt cagcagcttc ttttataacc aaaaaaacga ttcatttgca 662341 ttgcttcatt attctgtaga agaagactac aagaaaacag atgaagcaaa cgaaaagggc 662401 atcgaccctg aaccgacaac gattcatttt gcggaaggcc gccaaaataa atttaatgag 662461 ctgaaaagcc tgaaccaatt tatcagcgat attgctgttt ctgatgatga taaacgtatt 662521 ttattcacat catatacgca aaaaggaacg gagcaaaccg cttctattca aatgctcaat 662581 gcggatacga aaaaatatga aagcatcatc tcaaatcaaa aatcatttaa gctgttaatt 662641 gacgcacagc ctcagttttc taaggatggg aagaacattt attttcttgc cgaagccaag 662701 ggggctaaaa agctgaagga cgaaacaggg cgtgaagcta aggtgcggac gatttattcc 662761 tatagccttg agaataagac cttcaaaaaa gtatgggaaa atccgaacgg catcatcaac 662821 agcttttttg tgattaacta ataaaaacca ctcggcatga gctgagtggc ttttttaatg 662881 gatgaggtgc agggctaatg atccgagcca tttaaagata tgaatcagag gtaccgacaa 662941 aaacagaagt tcaacatatg agttcattgc aacattcagc tttttgaacg cagctctttt 663001 tttcaagtct ttttgctgct ggtttgagat cacgttatca ctcctcttat atccatatta 663061 taccattaaa acagacaaaa aagccctaaa cgtttacagt tttgggcttc tttcttcgta 663121 tttggcctct tgcaatgaga ggcttttatt ctgaaatata gaattttgtc tccgttcggg 663181 gtttgtttgc ttgcgggaga ctgcatttgt tatagggaag aactagcttg ttttcgtttg 663241 gctgttgttt tggagattca ctaatgaacg gatgccgtcg accattttac ttccgcacaa 663301 agggcacaat ggcgtatcac tgctggcgaa gttttttcgg gtccagccat tacagtcttc 663361 ttttgtgcat tcccaagtac tcacatcttc ctttggcagc ggttcttgat ttcgtttgtt 663421 atagtaagac ataaagtcac ttcttccctc atgtatttta ctgcacattt cctattgtct 663481 catacttttc cctaatctcc taattccttt ttctttatga ctttccaata accccatcta 663541 aaaaggagag gagtgtgctg ttaaaagcat ctggctcttc taaaaacggg caatggctgc 663601 ttttaggaaa ggtaacgagt gtcgcgtttg gaatattgct gcgcaagtgt tccccagctg 663661 ctgtagagaa aaatttcttg tcttccccga agcacagcaa tgccggcaca ttgatgtttt 663721 ggagggtgcc ccggtaatca gcggccgttt ggttaaataa aatcgtgcta gaaatggcag 663781 ccggctgttt gaggatttct gccagcatcc attctgtttc ggtctcggca ggcggttctg 663841 cgaacatatt ctggatgaag ctttcgtaga aaggcagcgg gtcagtttga atggcgtgca 663901 tcgctgtttt taagccgtca aaatcaaatg gaccatgttc ccagccctcc cattgatagt 663961 ccgaagcgga ttgatcgatg atcacagcgg cttgaatgtt atcattccca aactgattga 664021 gataatccca tacgacaaaa gcacccattg accagccggc aagaacgaca tgatcaagct 664081 ccattgcatt tagaaattcc cttatgtcac gggcatattg ggaaatggtg tggccgtgaa 664141 gcactttgtc agattcgccg tgtcctctaa gatcaagacg aatacattga taattggcag 664201 aaagcaccga aaattgtttg tggaaaaatt gtccgctcat cagcacccca tgtataaaca 664261 ggatcggcgt cccgctcccg tgtgtttcat agtaaaggcg tgtctgatct tctaatatga 664321 tgtatggcat gtttctcctc ctttagtttc catcatgagt atggctggct gctgttgagc 664381 tgatgatggc agctgtcgcg gctgcctgct gcgcttgaat gactgtttcg atagcggtgt 664441 atagtcctga ttccatcagc agatttttct ccatatgctc actgagatag aggctgacag 664501 caattttaaa gttcatttcc ttttgccatt taaaagcttt ttcctggttt aattcgtcag 664561 tgatgcacaa aacggttttg atatctggct cttccagaaa tgtgaggaga gcaaggtctg 664621 gataatgata atcctttgtt tttttgacag attcagtgat cgattgatat atctgtttgc 664681 aagcggaaac aagcatttcg ggctcttttt cactttgcaa ggccagaata tggctgacct 664741 gatgtaagta ctgtcctttt ttaaagccgt tggctgccag cagttgatag catgtttccg 664801 ccttctgtag cgcctgcaaa ccttttccgt tttctccaag cagtacggca agcggaacat 664861 tctgagttga agtgaggaaa taatgatttt tcttcatctg ctgataaaca gctagcccca 664921 tgttcatctg ttctttttgg tttgtcgttt cagatttgcc ggtgagcaag atcagagcgg 664981 aaaggtatgt gaacatatcc cgcttatacc ctagcttcac catttcattg tatacatcga 665041 tgaaagtctg aaatgtttgt tttgcctcat gctgaaaatg aatgtccaga atagatgcaa 665101 cagtaaagcg gtggtgtgaa ttgagtgttg agaagctgcc gatgtttgat ttgatatagc 665161 tgctcaaatc ataaaagcgc tgaaaatcaa actctctttt attcacaata tatgcagaag 665221 aaatgagcat taatatctga tcgtgtgaaa ctttccattt taattttgtt tttaattcag 665281 cataaatgga aatgtaatgc tttgtttttt catgtagatc gtgtgtgagc ataaaaagca 665341 gctccttttg ttgtttttac gtaatacgat aaatagggcc aaaggtttca taaagaaaaa 665401 acttgcctgc tagaggcaag tttgtcgggt tatttatggg gatcagttat atccatcggt 665461 ctcatcatgt catagtcttc atgctctaga atatggcaat gccatacgta tcgtccgctg 665521 tacggaccga atgtcgccgc gattctcagg acttcacctg catgcgcttg aatggtgtct 665581 ttccagccct tttcacttgg cggcggcggg acagccggac cggtatagga caattccccg 665641 ctttcttgat aacgggcgat atcaaacggc cgccggtcta atacacggaa ggagactaga 665701 tgcaggtgga tcggatgtgt tccgcgtgtc gggttgataa tggaccatat ttcagttgtg 665761 ccgacttttg gtgtttctgt gacgggatcg tgccagcgtt tgttattaag cagaaggacg 665821 ggtctgccgt attcgtcctg ggtgcctgcc agttttaacg ttctgatgtt ttgtattctt 665881 tcatgctgta ccgaagggta tgaggcgagg tacttcggct ttctgctttc gtctttttgt 665941 gccaatggtt ttgtgactct gaattgcatg atattcgcat ctgtttcagg attgacgtca 666001 ccgccgcagc ccgcgctgtt tgccaaaatg atcgattctc cttcatatgc tgtgaagtca 666061 atgatgatat cgtaacgttc agcaggcgca aggctgaaag aattcagttt aacagatcgc 666121 ggcaggagcc ctccatctga accaatctga ataaaatctc cgccattatc gagtgacagg 666181 ttataggttc ttgtattgga ggcgttgatg acacggaatc ggtatttcct tggctcgact 666241 tccaagtatg gccatacctt cccgttgacg agtatggttt ctccgcaaaa agccggaacg 666301 attgaaggat taggcagtga cggagaaggg ttttccggtg cgctcggata aaacaaagaa 666361 ccatcctcat tgatcgtgcg gtctgtgata agaagcggca catcgtattc gtctgaaggc 666421 agttttaagc gtttttcctt tgggtcatga atgatatatg caccgacaag tccggcatag 666481 acatttagcc tggtgagcgc catggcgtga tcgtgatacc acaatatagc cccgcgctgc 666541 tggtttggat aatgataaac ctctcttttg aaataaggtc ctgtttgttc aaagtctttg 666601 gaaaaccaag cctccggata cccgtcacta tcatctggcg tgacgccgcc gtgtaaatga 666661 acaacagtct ttacctcggg ctcttcatgc tggctgtcac tgtgatgaat ggtgtgatca 666721 atcggaagga aatgcgtgga aggaaggtta ttcatccatt ttacatatac gttttcattt 666781 cttttaacct caatggtcgg tcccggaaat aagccgttgt agccccacag gcgggttgga 666841 gggagatcgc gatggagctg atgagtgcat tcctccatgg tgacttcgta gtatgttttt 666901 tcttttgatt gctgtactgg ctttagtgta tctgggattg ggagagcatc cacaaatttt 666961 tcaagtgtca ttttcatctg tccttatcta aattttccaa attggtacta tagttaatga 667021 caataaggac gtgatggtta caaaaaatct tcgtgctgca gcccgcccga agaagaaaat 667081 aacaaaatcc taaacggcag gccgtttagg atttgatcag cattaaggca ggatatcggg 667141 ttgctgctgt gtgactgggt tggcagccgc tttctcgctc accttgcgtt ttctgaacac 667201 aaggtaagaa atcagaacga ttcccgtgat gacgcctgtc agcagcagct cgtctctcat 667261 ggaatcaata aacgccatgg acactaaaat tccgcaaatg gcgatgatgg tcaagtaggt 667321 taggaaaggg aagagccaca ttttgatctt caatgcttct gggtttgttt tttcgagttt 667381 tttccgcatt ttcagctggg aaacggcgat gacaagatag acgagtaaag cgattgcgcc 667441 tgatgagttg actaagaata aaaagacggt atccggtgaa aaatagttca ttacgaccgc 667501 gatataagag aaaaatgtcc cggccacaat ggcttgtacg ggaacgcctt ttttgctcaa 667561 tttcataaaa cggcgcggcg cttcatttct ttctgcaagt gaatacagca ttctggatgt 667621 ggtatacaaa cctgaattca ggcaagagag tacggctgtg aggacgataa agttcataat 667681 ctgtgcggct gcgggcactc ctatatgctc aagtacagcg acgaaagggc tttctaaaat 667741 atttgctgaa ttccatggca acagcgccac gacaatggcg attgagccca cgtaaaagac 667801 gatgatgcgc catacaacgg atctggtggc ttttgtcaca gattcgatcg ggttggatgt 667861 ttcccctgct gcaatggcaa cgatttcagt tcccataaaa gagaagatga caacgacaat 667921 gccgagcaat acggagctga tgccctccgg gaaaaatccg cctttgcctg taagattcga 667981 aaaaccgact ggctcactgc ccggtgcaaa gccaaaaata aaggcaaaac caacgattag 668041 aaaagcaatg atagtcacaa ctttaatgag ggagaaccaa tattcaaact caccgaaaga 668101 cttaacggag tagacgtttg tcagggtgag cacaatggtc aagatcaaac ttgtcagcca 668161 cagcggaata tcatggaacc agtattgaat aatgccagca ccggcaatgg cttcgatcgc 668221 tatgacgatc acccagaaaa accagtacag ccagccgatt gtaaatcctg cccacggtcc 668281 gatggcgtcg tgagcgtatt gagaaaacga tccgctcgtc gggtttacgg cagacatctc 668341 accgagcatt ctcataataa aaatcaccaa taatccggct aacgcgtaag aaacaacggc 668401 acccggaccg gtcgagtgaa tcactgaacc gctgcctaca aataggccgg ctccgattac 668461 accggcaatc gaaatcattg tcatatggcg ggtctttaat tcctttttta atcctgattg 668521 agactggttc ataagttacc tccttttaaa atgcaatcat tactgaatat tatgataatt 668581 gaaactctat cataaatata cagtttgtcg aaaattcgtg taagaaaata taccagctta 668641 tttcaaattt gtagtgtttt gtttgcgctt tcagcgaatg tgtggaaaaa atgtttcgtt 668701 ttttattcgc tgtgtgattt tgcgtaatat ttacaattcg atagaatgcg agaagcactg 668761 gtgtccttgg gtttgatggg atttttggcg gagcaaataa attggatgag agaaaaagtg 668821 ttccttcgtc actatttttc tgtggcgggt gaatcatgtt tctgtagacc cactgcggat 668881 cagctttgta agataataat aggaaaatgt gagcgagagg aggttttgta tggagagata 668941 tgatgaactg aaaaagggag aatccggagc gctggtcagc attgccgcgt atctagttct 669001 ttccgcaatt aaactgatca tcggttatct ttttcactcg gaagcactta cggcagacgg 669061 gttaaataac acaactgaca ttattgcttc tgttgctgtg ctgattggcc tgcgcatctc 669121 tcaaaagcct cctgacgaag atcatccata cggccacttt cgagcggaaa cgattgcatc 669181 gcttatcgca tcgtttatta tgatggttgt cggactgcaa gtgctgttca gcgccggaga 669241 atctattttt tctgctaaac aagagacgcc agatatgatt gcggcttgga cggcagcggg 669301 cggggcagtc ctgatgctga tcgtttaccg gtacaataaa aggctggcca aaaaggtgaa 669361 gagccaggcg ctccttgctg cggctgctga taataaatca gacgcattcg tcagtatcgg 669421 cacatttatc ggcattgtgg ctgctcaatt ccatcttgct tggattgata cggtcactgc 669481 gtttgtgatc ggtctgctta tttgcaagac cgcatgggat atctttaaag agtcatctca 669541 ctctttgaca gatggattcg acataaagga catttccgct tataaacaga caatcgaaaa 669601 aatctccggt gtgagccgtt taaaagacat aaaagcaaga tacttgggca gtacggttca 669661 tgttgatgtg gtggttgagg tatcggcaga tttaaatatt acggaaagcc acgatatagc 669721 caatgaaatt gagcggagaa tgaaggagga gcatgcgatt gattattcgc atgttcatat 669781 ggagccttta gaacaaaaat aatggagctt cctgtcacag gaagcttcag cgtgtcgaca 669841 aaccctcgca ttcgttgtca ggtctgcgct tcggtgctca cgaattagaa cattcgctcc 669901 gctcctatgc tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagatgacaa 669961 aaccctaaaa tgaaagccat tttaggattt tgtcaacaat ctggagcttc ctgccacagg 670021 aagctttttt gtgtgttttg gccagcttta ttggtaacaa tttgctagaa tcgttttttt 670081 atacagattg ctttttgtgg taaagttagg ttacattatg atgaattttg tagatgacta 670141 ggaggaaaat aatggcatat caagaagacc tgcatccttt gctggggaaa gcagttgaac 670201 atattaatag agtaatggtt ggaaaacgag acatcgccat actcagctta gcagcccttc 670261 ttgccaaagg gcatgtgctg cttgaggatg tacccggagt cggaaaaacg atgatggtcc 670321 gcgcgctggc aaagtcaatc ggcgccgatt tcaaaagaat ccaattcact ccggatttgc 670381 tgccatctga tgtaacaggg gtatctatct ataatgcgaa aacgatggaa tttgaatatc 670441 gtcccggccc aattatggga aatatcgtgc tggcagatga aatcaaccgt acctctccga 670501 agacacagtc ggctttgctc gaagcgatgg aagaggggag cgtcacggta gatggccata 670561 cgatgcagct tgccgatccg ttttttgtga tggcaacgca aaacccggtc gaatatgaag 670621 ggacctatcc tttgccggaa gctcagcttg accgtttttt attcaaactt cggatgggtt 670681 atccgtcctt taatgaagag cttgacgtct tatctcttca ggaaaaaagc catccgattg 670741 agacgcttga gccggttatt gcaaaagaag acttcatctt tttacagagg gaagtgcaaa 670801 atgtccgtgc tgatgacagc attaaggaat atatcgttga aattgtgcag aaaacgagac 670861 agcatccttc tgttcaatta ggcgtcagtc cgcgcggctc aatcgccctc atgaaagcgg 670921 cacaggcata cgcgctgctg catcatcgcg actatgtcat accggatgat attcaatatt 670981 tagctccttt cacgctgccg caccggatga tgcttcatcc tgaggcaaaa tttgaaggga 671041 ttcaggcaga agcgatcgta agggagatca tgtcagctgt gaaggtgccg gttcaaaggt 671101 cggcggtccg ctgatgaata agaaatggca atggctcgta tatggttgga agctgattat 671161 attaacttta ttgacggctg ctgttttttc ttatgcgatg tttcagggcg gctttgtcag 671221 ctggtttttg ttttacgcgt ttctcccttt tgtcttgtat gccgggctgt tggccttgta 671281 tccgctccgt tcttttcagg cttcaaggca aatggataaa acacaattgc atgcggggga 671341 caggctgggc gtaacggtta cgctgagaag aaagctgcca tttccgctga tgtatatggt 671401 gattgaagat tgcctgccag aaggtatcga gtcattaaat cgagacggag ccgcggccaa 671461 acggctcgtt tttccttggt ttaaacggag catgacgatg tcgtatgaat tagctcgggt 671521 accgcgcgga gagcatcact ttcattctgt cagggtgcga accggggatg ttcttggctt 671581 gattgaaaaa acagcatttt ttgagctgga tgataccttg tttgtttatc cattctatca 671641 gcgtttttcc tatcaggtga atgagaggca tcaggaagac ggtgtaagcg gttcttctcc 671701 tattcatcag caccattcct cagtcgcagc aagtgtgcgg aattatcagc cgggagaccg 671761 gtttgctgcg ttagattgga agacatctgc acggcggagc cagctgatga cgaaggaatt 671821 tgagccttct cgcagcaaaa atctgtttct gctgatggac cgtttttcct cagacgcatt 671881 cgaagaggtc gtttcagtga cagcttcgat tcttcattct gttttaaaaa acggcgcggg 671941 tgctggtctg gcttccatcg ggaaggaaaa aaacattttc cctattcagg aaggggatca 672001 gcattttaag cacatgcttc ggcatttagc catcgctcat tgtgatgcgg cagacccgat 672061 aagccgatat gcacgggaag agctgggaaa gccatctgtt cgccaagctg atcaagttgt 672121 tgtcacggga cagttaacgg aagatatgct gcacctcgca gaaataggag gcggccgggt 672181 tacggtgata ctggcaaaag agaaagatgc tgagctctct caagctgaaa atgtcatgat 672241 tgaacgcatg atgaaacgcc aaatcagagt tcggatcatg aggggcgggc gagtttcgcg 672301 tgttgtttag aaagagaggt gactggttca catgccgcac gatgatcaca agggaagccg 672361 tttgagcttg ctgttatttt attttctggc ttttttattg ctgtgggagt ggcttaggcc 672421 gcttgacagt tttactgaaa cgaaacatac aggctttttt agtgtcttta tcggcttgac 672481 gtttctgctg acttttttca ggatgaggtg gtttgtcacc gttccttttt gtgtcatatt 672541 tacattgatc tcgatacaca tcctgtttta tcaaggatct atattcgact tgagctgggt 672601 cagctctttt ttgcaggatg tctatctgaa tatcacgctg attcaatcag ggcaatggaa 672661 tgacatgatt ccttcatttc ggaccctgct gttttttgtg ctgctgtggc tgctggtcta 672721 tctcctgcat tattgggtga tttaccagag aagaattttg tttttctttt tgatgacagt 672781 agcgtatatt acgattcttg atacctttac gccatatgat gccacttttg ccgtaatccg 672841 tatcgtgctg atcggcttct ttatgctggg ccttttatac ttggaacgca ttaagctgat 672901 ggaaagaatc acactgccaa aaacatctgt cctgaaatgg tttcttcctt tatctgtatt 672961 ggttttggct gcaacgggat tcggactcgc cgctccaaaa tcagagccgg cttggcctga 673021 tccggtgcct tttcttaaaa aaatcactca tcaagaccgc gtgtctgcag gggaaagcaa 673081 aatcggatac gggaatcatg atgaatcact cggcggcccg ttccagcagg atgctacacc 673141 tgtttttaca tggcagggaa aagagcgtac gtatttccgt gtggaaacga aggacacgta 673201 taccggaaaa ggctggattg aaacagacac aggcatgtcg tatcagctta gcaatggaaa 673261 agttgaaaat ctgtggtttg accataaggt tgcgacagag cgccgcaccg tccgtgtaaa 673321 agtcgataag cactacgggt ataaccatct gatgtatccg attggtgcgg aaaccattca 673381 gccaaagcag gctgtctcac ttgaaatgaa cggcaacacg gagcaaattt ctccgatcag 673441 tgaacaagcc ggtgaaatca gaaatatggg gaattataca gtaacgtaca attccccggt 673501 ctataagctg gatgaactga gaaaggtaaa agtgagaaaa aacagtgagg agtacacatt 673561 cagcgatcgc tacatgcagc ttccagattc actgccagag cgggtgagaa cccttgcgat 673621 caaactgact caggatcacg acaatatgtt tgataaggtg aaagcggttg aggactattt 673681 agggtcaaat gcgttcacat atgaaacaga aaacgtgacc attccgaaga atgatgaaga 673741 ttatgtcgat caatttctct ttgaaacgaa aatgggttat tgtgataact tttcttccgc 673801 catggtggtg ctcttgcgct cggccggcat tccggcccgc tgggtaaagg gttatacgtc 673861 cggcgaatac aaagaagcag ggaacaaaaa tggcagcatt tacgaagtga caaataacaa 673921 tgcccattcc tgggtagagg tgtatttccc ggaacagggc tgggttacat ttgagccgac 673981 taaagggttt acaaatccgg ctcaatttac atcttctgac acaaaagact ctggcagcga 674041 tagcagcagc tcgccgaaga aagcaaaaga gaaacagaaa gaagagaaaa aacagccgca 674101 aaaagaggaa aaacaaaagg aaaagcggga gccagctgtt tctaaaaagc cgtccgcttc 674161 gcatactaat gccggtgcgg gcttgtatgc agcgcttgcg gttcttgcag tcctcctggt 674221 ggcagctgta ttgctgtatg ttttccgctc gttatggatt cctgttttcg ccgtgaggaa 674281 attgaagcgg cgcagtgatc agcacgcgtt ttttgaggca tatggcgcgc tgctgaaaca 674341 actgaagaga aaaggactgc cgaaacgaga cagtgaaacg ctgcgtgatt atgcaaaacg 674401 aattgatgaa aaatacgaca tagaagacat gtcaaagctg acattaagct atgaaagggc 674461 gctttacaga aatgaagatt cttcggcgct atggaatgat tcgagagagt tatgggaaaa 674521 tttaattaaa agaagatggt cttgaccgct tatcgacgtg ttgttagaat tagtgaatat 674581 tatcggagtc tgggagcgag ttggcctgac tccggcaaac ggccttgcca aagagggcgg 674641 agcgagcttc atatctgtcc tcgttttttt ctgtgtcaaa aaacttagag gagattaggt 674701 gacaaccatg acaaagttag tgaatgaaat gattcttgtc cttgatttcg gcagtcagta 674761 taaccagctg attacacgcc gtatccgtga attcggtgtt tacagcgagc tgcatccaca 674821 tacattgacg gctgaagaaa ttaaaaaaat gaatccaaaa ggaattattt tatccggcgg 674881 tccaaacagt gtgtatgatg aaaactcttt ccgctgtgac gagaaaatct tcgagcttga 674941 tattcctgtt ttgggaattt gctacggcat gcagctgatg actcattacc ttggcggtaa 675001 agttgaagcg gcaagccagc gtgaatacgg aaaagcaaac atccgcatcg aaggcacacc 675061 tgatttgttc agagatcttc cgaatgaaca agtggtttgg atgagccacg gcgatttggt 675121 tgtagaagtt cctgaaggct tcactgttga cgcgacaagc catcactgcc cgaactcagc 675181 aatgagcaaa gcggacaaaa aatggtatgg cgttcagttc cacccggaag tgcgccactc 675241 tgaatacggc aatgatcttc tgaaaaactt tgtattcggt gtttgcgaat gcgaaggcga 675301 atggtcaatg gagaacttta tcgaaatcga aatgcaaaaa atccgtgaaa cggtcggaga 675361 caaacaggtt ctttgcgcgc taagcggcgg cgttgattcc tctgttgttg ctgttttgat 675421 tcataaagcg atcggcgacc agctgacttg tatctttgta gaccatggtc ttctccgtaa 675481 aggcgaagct gagggtgtta tgaaaacatt cagcgaaggc tttaacatga atgtgattaa 675541 agtagacgca aaagatcgat tcttaaacaa actaaaaggc gtttctgatc ctgagcaaaa 675601 acgcaaaatc atcggtaatg aattcattta cgtgtttgat gatgaagcgg acaagctcaa 675661 aggcatcgac taccttgcac aaggtacgct ttacacagat atcatcgaga gcggtacagc 675721 aacggcgcaa acgatcaaat ctcaccacaa tgtcggcgga cttcctgaag acatgcagtt 675781 tgagctgatc gagccgttaa atacgctctt caaagacgaa gtgcgcgcgc ttggcacaga 675841 gctcggcatt ccggatgaaa tcgtatggcg tcagccgttc ccaggaccgg gactcggaat 675901 ccgcgttctt ggcgaagtaa cagaagaaaa acttgaaatc gttcgtgaat cagatgcaat 675961 cttgcgtgaa gaaattgcaa atcacggctt agagcgtgat atctggcaat acttcactgt 676021 tcttcctgac atccgcagcg ttggtgttat gggtgacgca agaacatatg attacacaat 676081 cggaatccgc gccgttacat caatcgacgg catgacatct gactgggcgc gtatcccgtg 676141 ggatgtgctt gaagtcattt cgacacgtat cgtaaacgaa gtgaagcaca ttaaccgcgt 676201 ggtgtatgat attacaagta agccgcctgc gacgattgag tgggaataag aatcaattaa 676261 tggaaaccat ctttttggca attttgccgg gaagatggtt ttatttgttt attacgaaca 676321 aaatccgatt ttgcgcgact attgttcgct ttttgtattg ttttttcaaa atgaacttgg 676381 tacaatagac acagaaatca aataagatga attcgtataa tcgcgggaat atggctcgca 676441 agtctctacc aagctaccgt aaatggcttg actacgtaaa catttctttc gtttgatata 676501 aataaaacac ggttatttat tcaaactgaa atccgtctgt agtcaagcgt cccaaaatgt 676561 attgggacgt tttttatttg gcgttttcag gacagaataa atagcaaaga gtgaagggag 676621 tcaaatagct tgaaaacgtt ttttcagttt gatgagctgg gcaccagcta tcgcaatgaa 676681 atcattggcg gattaacgac ttttttatct atggcatata ttttgttcgt caatccgatt 676741 acgcttgctt tggagagcgt gaaagatttt ccggaggcgc tgagaattga ccagggtgcg 676801 gtctttacgg cgacagcgct ggcgtctgca gcaggctgta tcttaatggg attaatagcg 676861 agatatccga ttgccatcgc gccgggtatg gggctgaacg cgttttttgc gttttctgtt 676921 gtccttggta tgggtatttc atggcaggca gctttgtccg gtgtttttat ttcaggtctt 676981 attttcgttg ctctttcttt aacaggtttt cgtgaaaaaa tcatcaacgc cattccgcct 677041 gagctgaaat tggcagtcgg tgcggggatc ggcctgttta ttacatttgt tggattacaa 677101 ggttcaggaa tcattacagc gaatccttct acgctcgtca cgatcggaaa cattcacagc 677161 ggtcctgtgc tgttaacgat tttcggtgtg attgtcacgg ttattttaat ggtgcttcgc 677221 gtgaacgcag gcgtgtttat cgggatgcta ttaacagcgg tagccggcat gattttcggt 677281 ttggttccgg ttccgactca aattatcggc agtgtgccaa gccttgcgcc gactttcgga 677341 caagcgtgga ttcacctccc ggatattttc tctgtacaaa tgctgatcgt tattttaaca 677401 ttcttgtttg tcggattttt tgatacagct ggtacacttg ttgctgtggc aacacaagct 677461 ggtttaatga aggaaaacaa attgccgcgt gcgggccgtg cgcttttagc tgattcatct 677521 tctattgtga tcggtgccgt gcttggtacg tctacaacaa cttcttacgt ggaatcaagc 677581 tcaggtgtcg ctgcgggtgc ccggtcagga tttgccgcaa ttgtaacagg gattctcttt 677641 ttactggcta cgtttttctc gccgctccta tcagtcgtta cgtcaaatgt aacagcgccg 677701 gcgcttatta ttgttggtgc attgatggtg gcgccgcttg gcaaaatcgc ttgggataag 677761 ttcgaagtgg ccgttcctgc tttccttacc atgatcatga tgccgttaac gtacagcatc 677821 gcgactggta ttgccatcgg atttattttc tatccgatta caatggtgtg caaaggaaaa 677881 gcaaaagagg ttcatccaat catgtacggg ctgtttgtcg tatttatcct gtactttatc 677941 ttcttaaaat aaggaatgaa aaaccagctg cactggcagc tggttttttt gttgcaaaag 678001 ataaaaccat ttcatacgat ataccgtcat gtagatgtgc cgccatgctt tacttaaatg 678061 gaaatgactt gactgttcag gaaggcttcg gtaccttata taagtgtttt attttcttgc 678121 tgaatggtat tccgccgtat ttttttgata ggagttgctg acatgacgga agaaagaaaa 678181 gaaacgtttg aagaagaaat taaccagagt gaaagaatag atgcagatga agaaccgcta 678241 tcgagaatgt ccagaaaggc gagccggcaa agcaagcaga agcaaaaaca aaagcagaaa 678301 ccgcgccagg aacgcggtga atcaactgtt aaagacaagc ttgcgtctgt ttgggcagcc 678361 atcaacagat attgcggttt tgcgttctcg attttaaaat ctccggcgaa aactgtcgta 678421 acggatggtt tttctcatta taagtacggt ctgatttcaa tgcttatatt cagtatcatt 678481 ttttcaattg ggaattggtt tcagttaaag gcaagctgga atcggccgct cggtttcgga 678541 gaacgccatc atgctttcta tgacgggttt ttagttgttc ttgtgtattt gctgatcttt 678601 ttcgcggtaa tggtctttgc tatatgggct gtctcccgct atatgatgaa gcagaaggtg 678661 acgttcagag aagcggctgc cgtattgggt tcattgcttg tacccgtaat tgctgtttca 678721 atcctttggc tgatctttgc gatcgtaaat atcccaatgc tgacagtact gtttacggtg 678781 ctgatcttgt tttccatctt ttttatcatc gcgctgtatg tacagcgtgt gtaccaggcg 678841 gcacaagatg caccaattga ttatatctat tgtgtatttg cagtagttgc gatagcgctg 678901 ctgtttacgg cagtgacttg gccgtttatt tctgaatata ttacggcgtc gttgattccg 678961 ctttaatgaa aaaaccggct aatcctagcc ggttttttta tgtcacactt tttacaaata 679021 tatctaaaaa acatagttga tttgtaggat taacccgtgt atgatgggga aaatgctgaa 679081 aacgtccagc gcaaaaacct ttatgtttaa ggaggatgat ggacatggct gatgtacttc 679141 gccgagcaat taaccaaaag aagcaatttt taaaaaccaa attactgctc tcggaatttt 679201 atcaaggaag aggggaacag cttgctgact acacgctgag tgagcttgag aaagaataca 679261 agtcccttca gaaaatgaaa aaagagatct gacaatagat ataaagaggt gagtctgctg 679321 aaaagcgggc ttttttgttt tgattttgaa aaggcgagaa agagggtaaa ctactactgt 679381 tcaacacata aaagcgtgtc gaaatatttt gcttaagctt acgggcgaag ctgattgtaa 679441 acggctcatt tctctagtag aatatgaatg ctttgtgcaa gctgaagagt agggggatga 679501 ataaaatgat gcaaaccatc ttatcaaatg ggatagccat ggttctcata attctcatta 679561 ttaatattgt ctatgtgtca ttttttacga taagaatgat tttaacgctg aaaggacagc 679621 gttatttagc ggccggcatc agtacgattg aaatactggt ttatgtgaca ggactgagtc 679681 tggtgctcga taacttagac cagattcaaa atgtgatcgc gtacgcgctc ggttacggtc 679741 ttggcgtaat tgtcggcatg aaaatagaag aaaaattggc gcttggctat attatggtca 679801 atgtgattac gaaggagctc gatcttgatc ttccgaagca gctccgtgaa aaaggctacg 679861 gcgtgacaaa ctgggtggca ggcgggcttg aaggcgaccg cacagccctt cagatcctga 679921 cgccgagaag atatgaactc cagctatatg atacgattaa aacacttgat tcaaaagcct 679981 ttattattgc gtacgaacca aaaacaatcc acggcggctt ctgggtcaaa gcggtgaaga 680041 agaggagaat taaagaataa tggcaaagcc gaagaagaaa aagtttgaag tgacagagca 680101 gcaaacgatt gatgcggtgc ttcagcaaat gaaagaagaa ggatatctgc ctgtaaggcg 680161 aatggaagag cctattttta tggaaaaaaa ggaaaatggg tcaattcaga tcgttccgtg 680221 cgggaaaaaa atcgtatttg aagggaaatt gatctaaaac acgaacatta gtagaatgaa 680281 tttttgtatc gttcgataat atcgttgaca ttatccatgt ccgttgttaa gataaacatg 680341 aaatcaaaac acgacctcat ataatcttgg gaatatggcc cataagtttc tacccggcaa 680401 ccgtaaattg ccggactatg caggaaagtg atcgataaaa ctgacatgga tatatcgcag 680461 aagcgaacga ctgacgatac atgtaccatg cccggtttgt attgcttcct cataagtgca 680521 atgcagagcg ggtatttttt attttctgaa aacaaaagca ttagaaggtg gggaacagaa 680581 tgcagccgct agtaggaatc atcatgggaa gcacttccga ttgggagaca atgaaacacg 680641 catgcgacat acttgacgaa ctcaatgttc cgtacgaaaa aaaggtcgtt tccgctcacc 680701 ggacgcctga tttcatgttt gaatatgctg aaactgctag agaaagaggc atcaaggtga 680761 ttattgccgg tgccggagga gcggcgcatc tgccagggat gacggctgcg aaaacaacac 680821 tgccagtcat tggagttccg gttcagtcca aggcgctgaa cggaatggat tcacttcttt 680881 ccatcgtcca aatgcctgga ggcgtgcctg ttgcgacaac atccatcggc aaagcgggtg 680941 ctgtgaacgc aggcctgtta gcggcgcaaa ttttgtcagc atttgacgaa gaccttgccc 681001 gtaagctgga tgagagaaga gaaaatacaa aacagacagt gttagaaagc agtgatcagc 681061 ttgtctaaac aaatcatcta tccgggagct gtaatcggca ttatcggcgg cggccagctt 681121 gggaaaatga tggctgtgtc cgccaaacaa atggggtata aagtcgcggt cgttgatccg 681181 gtgaaagatt cgccgtgcgg gcaggttgcg gatgtcgaaa ttaccgctca ttataatgac 681241 cgtgaagcga ttcgaaaatt ggctgaaatc agcgatatca tcacatatga gtttgaaaac 681301 atcgactatg atgcgctgca ttggctaaaa gatcatgcgt atctcccgca aggaagtgag 681361 ctgctgctta ttacccaaaa ccgtgaaaca gagaaaaaag caattcaatc cgcgggctgt 681421 gaagtcgcac cgtacagcat cgtcaaaaca aagaatgaat tgaaacaggc agtacaggag 681481 ctcaggcttc cggcagtgct gaaaacatgc cgcggcgggt acgacggcaa aggccaattt 681541 gtgataaaag aagaggcgca aatggagcag gcagccgctc tgttagaaca cggaacttgc 681601 attcttgaaa gctgggtttc ttttaaaatg gaactgtcgg tgatcgtcgt tagatcggta 681661 aacggtgaaa tttcaacatt tccgacagct gaaaacattc accacaacaa tattcttttc 681721 caaagcatcg tgcccgcacg ggtagagaaa gggattcagc agaaggctgc tgatctcgca 681781 gttaagcttg cagatgagct taaccttgtc ggaccgcttg ctgttgagat gttcctgaca 681841 gaggacggag agcttttggt caatgaactg gcgccaagac cgcacaattc agggcattat 681901 acgctggacc tttgcgagac gagccagttt gagcagcata tcagagcggt atgcgggctt 681961 ccgcttggga agacagattt gctgaagccg ggcatgatgg tgaatcttct cggcgatgaa 682021 gtgaagcttg ttgaggaaga cccggagctt ttaaaagagg caaagctata tatatacgga 682081 aaacatgaaa tcaaaaaagg ccgcaaaatg gggcatatta catttatgaa gcagcctgaa 682141 gacgaatgga ttcaggagat cacaaataaa tggatgaata gagacggagg acaagcagaa 682201 tgatcgaacg ttattcaaga cctgaaatgt ccgcgatttg gacggatgaa aacagatttc 682261 aagcatggtt agaggttgaa attcttgcct gtgaagcgtg ggcggagctt ggcgtcattc 682321 cgaaagaaga tgtaaaggtt atgcgcgaaa acgcgtcatt tgacatcaac cgcattttag 682381 aaatcgaaaa ggacacgcgc catgacgttg tcgcttttac gcgcgctgta tccgaatcac 682441 tgggcgaaga aagaaaatgg gtgcattacg gcttaacgtc aactgacgtt gttgatacgg 682501 ctctttccta cttattaaaa caggcaaacg atattttgct caaggatctt gagagatttg 682561 ttgacattat aaaagaaaaa gcgaaagaac ataaatacac agtcatgatg gggcgcacac 682621 acggcgtaca cgctgagcct acaacattcg gcttaaaact tgcgctttgg catgaagaaa 682681 tgaaacgtaa tcttgagcgc ttcaaacaag cgaaagcagg catcgaggtt ggaaagattt 682741 ccggtgctgt cggcacatat gcgaacattg atccatttgt tgaacaatat gtctgtgaga 682801 agctcggatt gaaagcagca ccgatttcca ctcaaaccct tcagcgtgac cgccatgctg 682861 actatatggc aacacttgct ttgatcgcga caagcatcga gaaattcgct gtggaaatcc 682921 gcggactgca aaagagtgaa acacgtgaag tagaggaatt tttcgcgaaa gggcaaaagg 682981 gttcatctgc aatgccgcat aaacgaaatc cgattggctc tgaaaacatg acaggcatgg 683041 cgcgcgtgat ccgcggctac atgatgacag cttacgaaaa tgttccatta tggcatgagc 683101 gcgatatttc tcattcttca gcagaacgaa ttattcttcc ggatgcgaca attgcgctga 683161 actacatgct gaaccgcttc tccaacatcg tgaagaactt aacggtcttc ccggaaaaca 683221 tgaagcgcaa catggaccgc actctcggcc ttatctattc tcagcgtgtg ctccttgctt 683281 tgattgacac aggcctgact cgtgaagaag cctatgatac agttcagccg aaagcaatgg 683341 aagcgtggga aaaacaagtg ccgttccgcg agcttgtgga agcggaagag aaaatcacgt 683401 cacgtctttc tccagaaaaa attgctgact gctttgatta caattaccat ctgaaaaatg 683461 ttgatctgat ctttgaacgt ttaggtttag catagaagaa gcttttagcg gcttcttcta 683521 agccgccgca gtttgaaaat tcccaacatt cgggttagga ggccttccgt gaatattgtg 683581 aagaatgaac ttttatacga aggaaaagca aaaaagatct acaaaaccga tgacgaaaac 683641 acgctgtatg tcgtgtataa agactccgcc actgccttta acggcgagaa aaaagcagaa 683701 atcagcggaa aagggcgctt aaataatgaa atttcaagcc tcattttcaa acaccttcat 683761 gctaagggca ttaacaatca ttttatcgag cgcatttcgg aaacggagca gctcattaaa 683821 aaggtaacga ttgtgccgct tgaagtcgtg gtaagaaatg ttgtggcagg aagcatgtcc 683881 aaacgtctcg gcattccaga aggcacggag cttgagcagc cgattatcga gttttactac 683941 aaggatgacg cgctgggtga tccgctcatc acagaagatc atatttggct tttgaaggcg 684001 gcgactcctg agcaggtaga aaccattaag tccattacaa caatagtaaa tgaagagctt 684061 caaagcatct tcgacgattg tcatgtcaga ttaatagatt tcaagcttga attcggttta 684121 gatgcagaag ggcaagtgct tttggcggat gaaatatctc ctgacacatg ccgcttgtgg 684181 gataaagaaa cgaacgaaaa gctggacaaa gatttattca gacgcaatct gggaagctta 684241 accgacgcat acgaagagat tttcaataga ctgggaggca ttcatcatgt ataaagtaaa 684301 agtttatgtc agcttaaaag aaagtgtact agatccacaa gggagcgctg tccagcatgc 684361 cttgcacagt atgacttaca acgaagttca agatgtgcgc atcgggaaat acatggagct 684421 taccattgaa aaatctgacc gtgatcttga cgtgctagtg aaagaaatgt gcgaaaaact 684481 tcttgcgaac acagtgattg aagattatag atatgaggtt gaggaggtag tcgcacagtg 684541 aaatttgcgg tgattgtgtt acccggctcc aactgtgata tcgatatgta tcatgctgta 684601 aaggatgagc tcggccatga agtggaatac gtctggcatg aggaaacaag ccttgacggc 684661 ttcgacggcg tgttaattcc gggaggattt tcttacggcg attacttaag atgcggcgcc 684721 atcgcccgat ttgcgaatat tatgccagct gtcaaacaag cagcggctga aggaaaacct 684781 gttcttggcg tctgtaacgg attccagatt ttacaggagc ttgggctgct gccaggcgca 684841 atgagacgca acaaagatct gaagttcatt tgccgtccgg ttgaattgat tgttcagaac 684901 gacgaaacct tattcacagc ttcctacgaa aagggagaat cgattacaat cccggttgcc 684961 catggtgaag ggaatttcta ctgtgatgac gagacgcttg ctacattaaa ggaaaacaat 685021 caaattgctt tcacatacgg ctctaatatt aatggaagtg tcagcgacat tgccggtgtc 685081 gtgaatgaga aaggcaatgt attaggcatg atgcctcacc ctgagcgcgc ggtcgatgaa 685141 ctgcttggaa gcgccgacgg tcttaaattg ttccagtcta tcgtgaaaaa ttggagggaa 685201 actcatgtca ctactgcttg aaccaagtaa agaacaaata aaagaagaga aactgtatca 685261 gcaaatgggt gtcagtgatg atgagtttgc attgatagaa tccattcttg gaagattgcc 685321 gaactacaca gaaatcggaa ttttttctgt catgtggtct gagcattgca gctataaaaa 685381 ctcaaagccg attctgcgta aattcccgac aagcggcgag cgtgtgctgc aggggccggg 685441 ggaaggcgcc ggaatcgttg atatcggtga taaccaagcg gttgtgttca aaattgaatc 685501 acataaccac ccatcagctc tcgagcctta ccaaggcgct gcgactggcg taggcggaat 685561 tatccgtgat gtattctcaa tgggtgcacg cccaatcgct gtattgaact ctcttcgatt 685621 tggtgaactg acttcacccc gcgtgaagta cttgtttgaa gaagtagtag cgggtatcgc 685681 cggatacggc aactgtatcg gcatcccgac agtcggcgga gaagtgcagt ttgacagcag 685741 ctatgaagga aatccgctcg tcaacgcaat gtgcgtcggt ttaatcaacc atgaagacat 685801 caaaaaaggc caggcaaagg gtgtcggcaa cacagtaatg tacgtaggag cgaaaacagg 685861 gcgtgacggc atccacggcg ctacgtttgc ttctgaagaa atgtcagact cgtctgaaga 685921 aaagcgttct gctgtccaag tcggcgatcc gtttatggag aagcttttgc ttgaagcatg 685981 tctggaagtc atccaatgcg acgccttagt cggcattcag gatatgggag ctgccggttt 686041 aacaagctca agtgcagaaa tggcaagtaa agccggttct ggcattgaaa tgaatcttga 686101 cctgattcct cagcgcgaaa caggcatgac cgcgtatgaa atgatgcttt ctgaatcaca 686161 agaacggatg cttttggtta ttgagcgcgg acgtgagcag gaaatcatcg atatttttga 686221 caagtatgat cttgaagcgg tttctgtcgg acatgtgaca gatgataaaa tgcttcgcct 686281 gacacataaa ggagaggttg tgtgcgagct gcctgttgat gccttggcag aagaagcacc 686341 ggtttaccat aagccttctc aagagcctgc ttactatcgc gagtttttgg aaacagacgt 686401 tccggctccg caaattgaag atgcgaatga aatgctgaag gcccttcttc agcagccgac 686461 gattgcgagt aaagagtggg tttatgatca gtatgactac atggtgcgca cgaatacagt 686521 tgtcgctcct gggtctgatg ctggtgttct cagaatccgc ggaacgaaaa aggcgctggc 686581 gatgacgaca gactgtaacg cgcgttatct ctatcttgat cctgaagtcg gagggaaaat 686641 tgctgtcgct gaagcagcgc gcaacatcat ttgctcaggc gcagaaccgc ttgcggtgac 686701 agataacctt aacttcggaa accctgagaa gccggaaatc ttctggcaga tcgaaaaagc 686761 ggcagacggc ataagcgaag cgtgcaatgt tctcagcact ccggttatcg gcggtaacgt 686821 atcgctttat aacgaatcaa acggcacggc gatctatccg acaccagtta tcggcatggt 686881 cggcctaatt gaagatacag cgcacattac aacacagcat ttcaaacaag caggagatct 686941 cgtatacgtg atcggcgaaa caaaaccaga gtttgccgga agcgagctgc aaaaaatgac 687001 agaaggccgt atttacggca aagcgccgca aatcgatctt gatgtagagc tgtctcgtca 687061 aaaagcactg cttgacgcga ttaaaaaagg cttcgttcaa tctgcgcatg atgtgtctga 687121 aggcggctta ggcgtagcga ttgcggaaag tgtcatgacg acggaaaacc ttggcgctaa 687181 tgtgactgta gaaggggaag cggcgttatt attctctgaa tctcaatctc gcttcgtcgt 687241 ttcagtgaaa aaagaacatc aagctgcgtt tgaagcaact gtcaaagatg cagttcatat 687301 tggtgaggta acagctgacg gaattctggc gattcaaaac caagacggac aacaaatgat 687361 tcatgcgcaa acgaaagagc ttgaacgcgt atggaaagga gctatcccat gcttgctgaa 687421 atcaaaggct taaatgaaga atgcggcgtt tttgggattt ggggacatga agaagccccg 687481 caaatcacgt attacggtct ccacagcctt cagcaccgag gacaggaggg tgctggcatc 687541 gtagcgactg acggtgaaaa gctgacggct cacaaaggcc aaggtctgat cactgaagta 687601 tttcaaaacg gcgaactcag caaagtaaag ggaaaaggcg ctatcgggca cgttcggtac 687661 gcaacggctg gaggcggcgg atacgaaaat gttcagccgc tcctcttccg ttcccaaaac 687721 aacggcagcc tggcgcttgc tcataacgga aatcttgtca acgccactca gctgaagcag 687781 cagctcgaaa atcaagggag catctttcaa acctcttcgg atacagaggt tttggctcac 687841 ctgatcaaaa gaagcggaca cttcacgctg aaggatcaaa ttaaaaactc gctttctatg 687901 ctgaaaggcg cctacgcgtt cctgatcatg accgaaacag aaatgattgt cgcacttgat 687961 ccaaacgggc tgagaccgct atccatcggc atgatgggcg acgcttatgt ggtcgcatca 688021 gaaacatgcg catttgacgt cgtcggcgca acgtaccttc gcgaggtaga gccgggagaa 688081 atgctgatca ttaatgatga aggcatgaaa tcagagcgtt tttccatgaa tatcaatcgt 688141 tccatttgca gcatggagta catttatttc tccagaccag acagcaatat tgacggtatt 688201 aatgtgcaca gtgcccgtaa aaaccttggg aaaatgctgg ctcaggaatc cgcagttgaa 688261 gctgacgtcg taaccggggt tccggattcc agtatttcag cggcgatcgg ctatgcagag 688321 gcaacaggca ttccgtatga gcttggctta atcaaaaacc gttatgttgg cagaacgttt 688381 attcagccgt cccaggctct gcgtgagcaa ggcgtcagaa tgaagctgtc tgcggtgcgc 688441 ggggttgtag aaggcaaacg cgtcgtgatg gtggatgact ctatcgtgcg aggaacaact 688501 agccgccgga ttgtcacgat gctaagagaa gcgggtgcga cagaggtgca tgtgaaaatc 688561 agttcaccgc cgatcgctca tccgtgcttt tacggcattg acacttccac acatgaagaa 688621 ctgatcgcgt cttcgcattc tgttgaagaa atccgtcagg aaatcggagc cgataccctc 688681 tcatttttga gtgtggaagg gctgctgaaa ggcatcggca gaaaatacga tgactcgaat 688741 tgcggacagt gtctcgcttg ctttacagga aaatatccga ctgaaattta ccaggataca 688801 gtgcttcctc acgtaaaaga agcagtatta accaaataaa acttgaaaaa tgacataaag 688861 gcagcgcagt tcggctgcct ttctctttct gccctcgttc ggggagatat tttgaaaagc 688921 gccttaaagg agtgaatagg atgtctgaag catataaaaa cgcaggagtt gacatcgaag 688981 ccggatatga agctgtaaaa cgaatgaaaa aacacgtgga gcgcacgaaa cggcttggcg 689041 ttatgggcag ccttggcggt tttggcggca tgtttgacct gtctgagctt tcttatcaaa 689101 aaccagttct catttcggga acggacggtg tcggcacaaa attaaagctc gctttttcca 689161 tggataagca tgacacgatt ggcgtggatg ctgttgcaat gtgtgtcaat gacgtgctgg 689221 cacaaggtgc agagccgctg tttttcctcg attatttagc ggttggcaaa gcggacccag 689281 tgaaaattga acagattgta caaggtgttg cggaaggctg tgagcagtca ggttcagcct 689341 tagtcggcgg tgaaacggct gaaatgccgg ggctctatac agctgatgaa tacgatattg 689401 ccggtttctc agtcggagtg gcagaaaagg acgaaatcgt gactggagaa aaaattgaag 689461 agggccatct gttgatcggc ctcagctcca gcggccttca cagcaacggc ttttcccttg 689521 tcagaaaagt gcttctggat gatgcggagc tggacctcga tacaacatat gagccgtttg 689581 aacgcccgct tggcgaggaa ttgcttgaac cgacaaggat ttacgtgaag cctgtgcttg 689641 ccgcggtcaa aagcggaaaa atcgacggca tggcgcacgt gacaggcgga ggatttattg 689701 aaaatattcc gcgtatgctt ccggaaggct taagtgcgga aattgatcat ggctcatggc 689761 cgatcccgcc gattttttct ttcttgcaag agtacggcaa gctaaaggaa gaagacatgt 689821 tcaacgtctt taatatgggt atcggttttg ttttggcagt caaagaagag catctgacag 689881 atgtgatcgg aacgcttgaa agccatggcg aaaaagccta tttaatcggg cgtgtgaaaa 689941 aaggtgaagg cgtcacattc ggcggtgcgg cactttcatg aaaaagtttg cggtatttgc 690001 atcaggaaac ggttcaaact tcgaagccat cgtcacgcgt ttgaaggagg agaactggga 690061 tgcgtcagca gcgctcctcg tttgcgacaa accgcaggcg aaagtcatcg aacgggcgga 690121 agcattccac attccatcct tcgcatttga gccgaagtct tatgaaaaca aggctgcatt 690181 tgaacaagcc atcattgaac agcttcgtct tcacgaggtt gaattgattg ctcttgccgg 690241 ctatatgagg ctgatcggtg atacgctcct tcaagcatat gggggaaaaa tcattaacat 690301 tcacccatcg cttcttccgg cgtttcctgg aatcgacgca gtcggacagg cgttccgggc 690361 gggtgtgaag gtggccggaa tcaccgtgca ttatgtcgat gaaggaatgg atacaggtcc 690421 gatcatcgct caaaaggcaa tcgaaattga tgaacatgat acattggaaa caatcgaaca 690481 gcgaattcac aagcttgagc ataaatggta tccgagtgtg attaaacagc tattaggatt 690541 aaataacaga ggtgaaaagg catgaccatt aaacgtgcat taatcagtgt ttcagataaa 690601 acaaatctcg ttcctttcgt aaaagaactg acagagcttg gcgttgaagt catctccaca 690661 ggcggaacga aaaagcttct tcaagaaaac ggtgtggatg tgatcggaat ttctgaagtg 690721 acaggctttc ctgaaattat ggacggccgg ttaaaaaccc tacacccgaa tattcacggc 690781 ggccttctgg cggttcgcgg caatgaagag catatggcgc agatcaatga acacgggatt 690841 cagccgattg acctcgttgt cgtcaacctc tatccattta aagaaacgat ttctaaagaa 690901 gacgtcacgt atgaagaagc gatcgaaaat atcgacatcg gcggacctgg catgctgcgc 690961 gcggcatcaa agaaccatca ggatgtcacg gttatcgtcg atccggccga ttacagccca 691021 gtgctaaatc aaatcaaaga agaaggcagc gtatctcttc agaaaaaacg cgagctcgcg 691081 gcaaaagtat tccgtcatac tgcggcatat gatgcactga tcgctgacta tctgacaaat 691141 gttgtcggtg aaaaagaacc agagcaattc actgtgacat ttgagaaaaa acaatcgctt 691201 cgctatggag aaaacccgca tcaggaagca actttctatc aaacagctct tcctgtcaaa 691261 ggctccattg cgcaagcaga acagcttcac ggaaaagagc tttcttacaa caacattaaa 691321 gacgcggatg ctgcagttca aatcgttcgt gaattcactg aaccggctgc tgttgctgtg 691381 aagcatatga acccgtgcgg cgtgggaaca ggaaaaacga tcgcagaagc gtttgacaga 691441 gcgtttgaag cggataaaac atctatcttc ggcggcatta tcgcgctgaa ccgtgaagtg 691501 gacaaggcaa ctgccgaagc gcttcacaac attttcttag aaatcatcat tgcgccttca 691561 ttcagccaag aagcgctcga cgtcctgact gcgaagaaaa atctccgtct gctgacgctt 691621 gacgtatccg ccgctgttca aaaggaaaaa cagctgacat ccgttcaagg cgggctgctg 691681 attcaagatt tagatatgca cggcttcgat gatgctgaga ttagcattcc gacaaaaaga 691741 gagccgaacg agcaagagtg ggaagacttg aagcttgctt ggaaagtcgt gaagcatgtg 691801 aaatcaaatg cgattgttct cgcgaaggac aacatgacag tcggcgtggg agcaggccaa 691861 atgaaccgcg tcggatcggc aaaaatcgca atcgagcaag caggggaaaa agcgaagggc 691921 agcgcgctcg gttcggatgc atatttccca atgccagata ctgtcgaaga agcggcaaaa 691981 gcgggcgtta cagccatcat tcagccaggc ggatcgatcc gagatgagga ttccatcaaa 692041 aaagcggatg aatacggcat tgccatggta ttcaccggca tcagacactt caaacattaa 692101 ggggatgaaa acgacgtgaa tgtattaatt atcggtaaag gcggaagaga acatacgctg 692161 gcgtggaagg cagcgcaaag cagcctcgtc gagaatgtat ttgccgctcc cggaaatgac 692221 ggcatggcag cttccgctca gcttgtaaac attgaggaaa gcgaccacgc agggcttgtc 692281 tcatttgcaa aacaaaatca ggtcggcctg accattgtcg gccctgaggt tcctttaatt 692341 gaaggtctgg tggatgaatt cgaaaaagcg ggcttacatg tgttcggtcc gtcaaaagct 692401 gcggcgatca tcgaaggaag caaacagttc gctaaggatt taatgaagaa atacgacatt 692461 ccgaccgcag aatacgagac gtttacatcc tttgatgagg cgaaggcata tgtgcaggaa 692521 aaaggtgctc cgattgtgat aaaagcagat ggacttgcag ctggaaaagg cgttactgtg 692581 gctatgacag aggaagaagc aattgcgtgc ttgcatgact ttcttgaaga tgaaaagttc 692641 ggtgatgcga gcgcgtccgt tgtcattgaa gaatatcttt ctggtgaaga attttctcta 692701 atggcctttg tcaaagggga aaaggtgtat ccgatggtga ttgcccagga tcacaagcgg 692761 gcgtttgacg gagacaaagg cccgaataca ggcggcatgg gcgcctactc gccagttccg 692821 caaatttcgg aagaaacggt ccgccatgct gtagaaacga tcgttaagcc ggctgcaaaa 692881 gcaatggtac aagaaggccg ttccttcact ggcgttttgt acgctggatt gatgcttact 692941 gaaaacggct cgaaggtcat tgaatttaat gcccgtttcg gcgatccgga aacacaggtc 693001 gtgcttccgc gcatggaatc tgatctggta caggtgcttc ttgatctttt agatgataag 693061 gaagttgact taagatggaa ggataccgcg gcagtgagtg ttgtgcttgc atcagaaggg 693121 tatccggaaa gctatgcaaa aggcacgccg atcggcagcc ttgcagcaga aactgagcag 693181 gtcgtggtct tccatgccgg aacgaaagca gaaggtggag agttcgttac aaacgggggg 693241 cgcgtcgcca atgtgacggc ttttgatgaa acgtttgaag cggctagaga ccgagtgtac 693301 aaagcggttg atgaaatttt caaaccggga ctctttttca gaaaagacat tggggcacgc 693361 gctttaaagg ctgcccaaaa ataagtgagg aaaacccgca gaatagctgc gggttttttg 693421 ttatcaaaaa gcgggatggc agctagaaga agaaagcaca acgagcgtgg ttggttttcc 693481 atgggccatc gaggtgtcaa taaaatcctc aagcgtatgt accgattcag tcacgacctt 693541 tgtcacatag ctgtacatcc ccgtgatgcg gtggttttct gctacatcag gatgcgatgt 693601 tgcaaaggcg gcgtagtgct tgcagctttt cggctccatg agaataaaag cggtgacatg 693661 cttgtttagt ttttcgtaac agatattcgc gctgtagccg gtaatcactc ctttgtcttc 693721 cagcttcctg acacgctccg ccgcgcttgg cgagctgagt ccgacaagct ttcccagctc 693781 aaccatcgtt aatctgccgt ttcgctgcaa atgcgagaga atctgaaggt ctgtatcgtc 693841 catttgtctg gctcctttac atatttaggc gaatgaatga aaattccttt gatcgtaagg 693901 taatgctgtt gatttaactt cattgtagca tatggatgcc gtcttatttt ttctataata 693961 aagccatcaa tcagagaggg ggcatcatgt tgccagaatt gcagcgctct attacttgga 694021 tacaagggac ggcgttaacg attggggcgg ttttaggatg cgggatatta atcctgccgt 694081 ctgtcaccgc ggacacggcc ggccccgctt ctttatttgt ttgggtgttc atgtccttct 694141 tatccttttt tcttgtcggc acgctggccc ggcttgtgaa aatagcgcct agcgcgggag 694201 gaatcacggc ttatgtgcag ctggcctttc agaaaaaagc cggggctatt ttgggctgga 694261 tcatgttagg gtccgttccg atcggcgttc ccatcatcgc tttgactggc gcgcattacg 694321 tcagttacat cacagaggcg gccgattggc agattacatt gattgctggt tgcatgctgg 694381 ctatatctat tttgcttcat atgagaggga ttcaactatc agcaaacatt agtacactcg 694441 ttatatgtgt catcgtattt ctgcttgtca cttctattgc tgtgtcattg ccacacgtca 694501 cgatagcaga attcaagccg tttcttccgc atggctggtc tgccgctgga tctgtttctg 694561 ttatgatttt tttctctttt gtaggctggg aaatgattac cccgttggct gaggaatttc 694621 atcgtcctga aaaagatgtc ccgctcagct tgtttttggc agcgtcttgt gtggcggggc 694681 tgtatatcat gctgtcattt gtgaccgtgg gtactcattc atatggagag aatggagaaa 694741 ttgcatcgct tgccatgctc atttcaaaag gagcaggaga aagcggtgta tatgtcacgg 694801 tatgtttagc gctgtttatt acattcgcca ccatccatgc caatattgcc ggtttttcaa 694861 gaatggtgta cgcattggcg agagaggggc acatacccgt attttttgga aaactcagtg 694921 cgacaaaacg tacgcctatt cgcgttttga cagcgatggc cgcagtgttt ggcttagtgc 694981 ttgcagcgca tggtctgttt caaatcgatt tgacgactct gttgaaaggg ccgagcgcgg 695041 cttttatcgc atcttacata tgtacaatgg cggcagcact gaaactgctg ggcaggagag 695101 atataggctg gtggatggcg ctcggggcat ttgtggcgtg cgcggtgatt tattcattca 695161 gcggctgggc actgctttat ccggcagtgc tggcagctgc aggatatttc tatatgaaaa 695221 caaagggtgg gcataaaaaa aagcttgatc acgttttgtg atcaagcttt tccatttatc 695281 cgttttgatg ctcgttattt ccagaatcgc tgtgttgaaa catgtaggtc acaggacaga 695341 agcgcaagat tcccgaaccc gctttcatgg cccccataaa gatgtaaaag agatgcattc 695401 tgcaccaagg ttttttcgta aactttgcac tggcggctga cataatcgtc aatccgcagg 695461 cgattctgaa cacggcattg atgagactga tgtttggctt caaggaaatc cgctcctttt 695521 acttaaaaaa gttttttaat cgaaccttca aaaatttgta acgtttttat cgtgcgtgat 695581 gaggaaggat gtgataccat gagtctaata catgtaaagg agagtatgtg aatgtccgaa 695641 cgcaccttta actggaaaaa caaagacatc agggcacagg ttgatgttgt agactcaaag 695701 ctgcttccaa cgctcctttt acggaatgct ctcgtcttaa atccatatgt aaaacaatgg 695761 ctgaaaaaaa acatttggat ttatcaggac cgcattgttt atgtgggtca tgaacttccg 695821 aatagagccg aagaaattca tacgattgat tgtgaaggaa aatacattgt gccaggttat 695881 attgaaccgc acgcacatcc ttttcaaata tataatcccc aaacactggc ggaatatgtg 695941 tctcaatacg gaacaacgac attcgtgaat gataacttat ttttgctttt gcaaagcgga 696001 aaaaagaaag cgcttacgat tttgaatgaa ctcaaaaagc agcctgtcca gtatttttgg 696061 tggtcacgct atgacctcca gaccgaggtt ctgaacgagg accacgtcct tccatttgac 696121 gtcagaaaac agtggattga acatccggat gtgattcaag gcggagaaat gaccggatgg 696181 cctcgcctgg tagatggtga tgatttaatg ctccactgta tgcaagctac aaagaaacag 696241 agaaaacgta ttgaagggca ttttcccggc gcttctgata aaacgcttac aaaaatgaag 696301 ctgttcggtg cggattgtga tcatgaagcg atgacaggtg atgaagtgat gagaaggctg 696361 gaactgggct attatgtttc ccttcggaac tcttccattc gccccgatgt aagaaaaatc 696421 ttgcaagagc tgcatgagaa gggcttccgc tattatgacc acttctttta cacgacagat 696481 ggcgcaaccc cgaatttcta taaaggcggc atgacaaacg agctgattcg cattgcgtta 696541 gaagaaggcg tacctgcaat cgacgcctac aatatggcat catttaatat cgcaaagtat 696601 taccaaatgg atgattattt aggagttgtc ggaccgggca gactggcatc gctaaacata 696661 ctggaagatc cgttaaatcc gaatccagtg actgttctgt caaaagggac cattctgcgt 696721 gaaaacggct gtgatttgaa ggcgtttaca aagacggact ggcacaaagg cggtcttgtc 696781 ccgcttgagc tttcatatga tatgacgatg gatgacttgc agttttctat gccgatgggc 696841 gtgaaaatgc ggaatgcggt tattatggag ccatatatga ttgagatcga caattcgatg 696901 gaacagctct cgtttgacca tgatgaaagt tatttgacga tgctcgacag acacgggaaa 696961 tggcgcgtca atacgatgat aaaagggttt gcctcaagcg tgcagggatt tgtaagctcc 697021 tttacgacga cgggcgacat tgtcgcgatt ggaaaaaata aagcggatat gctgctcgct 697081 ttcgcccgca tgaaagaaat cggaggagga attgttttag cggagaacgg aaacattctg 697141 catgaaatcc cgcttgcgct gtgcggctgc gcctcttcgg aagcgtatga agacgtgctt 697201 gagaaggaac aaaagctgag agatcttttg actgaaagag gctatgagtt ttgcgatcct 697261 atctatacgc tgctcttttt gcaaagtacg caccttccgt atatacgcat tacgccaaga 697321 ggaatattcg acgtcatgaa aaaaactgta ctctttccat cgataatgcg ttaaaatata 697381 aaagagcagg gagccgacat atgaaaaaat ggatgacagt ttgcgcgctg tgtttcgtgt 697441 tttttctgct ggtatcctgc cagcagaagg atgctgtccc ggatactgca aagaagctga 697501 aagctccttt aacggggcta aagactgaac agaaagtgac tgaacgccgc cctgttgctg 697561 ttgtggtgaa caatcacccg aaggcgaggc cgcagtcggg tctgtctaaa gccgacattg 697621 tcatagaagc gctagccgaa gggcaaatca caagatttct ggccattttc caaagccaga 697681 tgcctgaaac tgtcggacct gtgcggagcg cgcgggaata tttcgtcact ctcagcaatg 697741 gctttgacag catatttgtc catcacggct ggagtcccgg cgccaaaaag cagctggaat 697801 ccggagctgc cgattatatg aacggattgg attttgacgg aagcttattt tggagagctg 697861 atttcagcaa accgccccac aattcctata cgtcttatga ttacataaaa aaggcggcag 697921 aacaaaaggg ttataagctg aagcaggaaa caaatccgct gctgtttcaa acatcagatg 697981 caaaacctgc aaatgaatct tacaatgttc gggtagatta tggaacaaat aacgttacaa 698041 atcttgtcga atacaactat gataaaaaag ctgaatttta tacaagaagc tctgatggtg 698101 tcataacgac agaccgggaa accggaaagc cggttgcaat gcaaaatatt ttcattgttg 698161 aagccagcca tcatattatt gatcaagatg gaaggcggga catcgacttg gaatcaggag 698221 gaaaaggtct gttgtttcag cacggaaacg tcattgaaac agactggaaa caagtgaatg 698281 gcagaattgt gccggtaaaa gacggcaagt ggcttccgtt tgtgccagga aagacttgga 698341 tcaatatcgt acctgatctt gatgcggctt ccattagtaa aggagaaggt gtgtaacgat 698401 gcaaatcgat aaattacgcg gcaaagagct ggaccagtta tttaactcga tcttatcgct 698461 gaaagacctg gaggaatgtt accgattctt cgatgatcta tgcacaatta acgaaattca 698521 atcgctggct cagcgccttg aagtggcgcg catgcttcgc gaaggaaaca cgtatcataa 698581 gattgaaaca gaaacaggcg cttccacggc tacgatttcc cgtgtgaaac gctgcttaaa 698641 ttacggaaat gacgcttatg aaatggcgct tgaccgtgtg aaggagacgg aaacagagtc 698701 ttcttccaaa taaaaaaccg ccctgccgtc tggcaagggc ggtttcttta tgaaacaaat 698761 tgatggatca ggttgtcgat attgatgata ctgccatcct ctttccgata gacaacatgc 698821 tccttggaaa aatgaatcgg cgaattaatc cctgctgcgg ctgcaaggtt aaatagtccc 698881 tcgcgcaatg aaataacgta gttgcagaca cgatgctgtt tttcctcaac gctcagtgct 698941 ttttgcaatt tcggatctgt cgtcgccaca cctgccggac aggtgttggt gtggcagacg 699001 agagcgcgga tgcagccaac ggaaaacatc atgccgcgtg cgatgttaac aaagtcagcg 699061 ccgagggcta aggcgaccgc gattttatca ggagtcagga gctttccgga agcaaagatt 699121 ttcagctggc tgcgcaagcc gtactgttta agaagcgtgt ccacaatagg cagcgctgtc 699181 ataatcggaa ggccgactgt atccgcgagc tcgtaaaagg aagctccggt accgccttca 699241 cttccgtcga tcgtgataaa atccggatgc tttccgcttt tctgcatatg agagaaaagc 699301 tcatgcaatt cttcaggatg ccctgcgacc agtttgatgc cgactggctt ttgtccgaca 699361 tctctaagtt tttcaataaa gtcgagcatt tcaggagggt ttgagaattc ataaaagcgg 699421 ttcgggctgt caatcgactt tccaggttcg acattccgaa tgtctgccac ttcctctgat 699481 actttggcgc cgtccacatg gccgccgcgg gttttcgctc cttgtgccag ctttagctca 699541 aacgctttaa tctggtcaat cctgcttttt cttttaaatt cctcccacga aaattccccg 699601 tttcttttgc gcacgccgaa taggcccggt ccgatttggc aaatgatatc ggcgccgccc 699661 tttaagtgat attcagacaa tcccccttca cctgtattca tccaggtgcc gcctgccaga 699721 tggagccctt ttgagagcgc cgtaacagcc cgttctccaa gagaaccgta gctcatggca 699781 gactggccga ctaagccctt cacataaaat ggcttctcgc atgtatgctc gccaatcacc 699841 tgtacatcat caggatggag aaaatacggg tctgccttga tatgttcggc atgctccttg 699901 cgtttgaaca gattgtcagc atccatttta tagatttggg tttcaatttt tggcgtttga 699961 tttacatgca tttcttccct ttgttttgga aacatagcgt tacggatata atagccaggt 700021 ttatcaaaat ctcttacaga tccaaagccc atcattctgc ttttgtattt gccggagatg 700081 acggtttgct catattcctt tcgtgaaaat ggctgctctt cattgtcatt gctgtataaa 700141 tactgtctga gctccggccc gattttttca aggatatacc gaaaccttcc gatgacggga 700201 tagttgcgaa gaattgagtg ctcctgctgt ttttcatcct ttatgtagat ccaggcaaac 700261 aagacgatcg ggatagcgat gatcccaatg ataaatgcga tgagtgctat tatgatggtt 700321 tccatctctc agcctccctt tttatgtaac catttccaca gtagaacact ttccaaacaa 700381 tagcagaagg aatctggtga aaaatgtgtg ctcctgccga tacaggactc accatgcagg 700441 tactgccata tgctctcttt ttttatgaaa aaagaatcaa aacacctttt tcagtgaata 700501 acgagattaa cggctttttc cgtttttccg cgctatgtga atttgttata atgtttaaat 700561 ggtaacaaac gaatggagga acgtatgacg tgtacgatgt aacggagtgg aagcatgtct 700621 ttaaactcga tccaaataaa gatttgcctg acgaacagct ggagattctt tgcgaatcag 700681 gaacggatgc ggtcattatc ggaggaagcg atggtgtgac agaggataat gtcctgcgga 700741 tgatgtctaa ggtaagacgg tttttggtgc cgtgtgtcct agaggtatca gcgattgaag 700801 cgattgttcc cggctttgac ttatatttta ttccgagtgt attaaacagc aaaaacgcgg 700861 attggattgt cggaatgcac cagaaagcca tgaaggaata cggagaactg atgtctatgg 700921 aagaaatcgt ggcggagggc tactgcatcg caaatccaga ttgcaaagcc gcggcactga 700981 ctgaagcgga cgccgatctg aatatggatg atattgtcgc ctatgcgcgt gtgtcggagc 701041 tgctgcaact gccgattttt tatttagaat acagcggcgt gcttggagac atagaagctg 701101 tcaagaaaac gaaggctgta ttggaaacgt ccaccttgtt ttacggcggc ggcatcaagg 701161 atgcggaaac ggccaagcag tacgcagagc atgcggacgt gatcgttgta ggcaatgcgg 701221 tgtatgaaga ttttgacagg gctttgaaaa cagtagcggc tgtgaaaggc gagtagtaaa 701281 ttgtacggat ttggtttatg atagaacgta tgttttgtat aggcgggtga acaaattttg 701341 aattatatta gcaatcaatt actaagcggt ttaaaccccg ttcagcagga agcagtcaaa 701401 acaacggacg ggcctctttt gctgatggcg ggagcgggta gcggaaagac gcgtgtcctg 701461 acccatagaa ttgcttattt aatggcagaa aagcatgtgg cgccgtggaa cattctggcg 701521 atcacattta caaataaagc ggcacgcgaa atgaaagaac gtgtggaaag catcctcgga 701581 cccggcgcgg acgatatctg gatctccaca ttccacagca tgtgcgtgcg gatcttgcgc 701641 agagatatcg accggattgg gatcaaccga aatttctcca tccttgatac ggctgaccag 701701 ctttcagtga tcaaggggat tttgaaggag cgcaatcttg atccgaagaa gtttgacccg 701761 agaagcatcc tcggcacgat cagcagtgca aaaaacgaat tgaccgaacc ggaggaattc 701821 tctaaagttg ctggcggcta ctacgatcag gtggtcagcg atgtatatgc tgattatcag 701881 aagaagctat tgaaaaacca gtcgctcgat ttcgacgatt taattatgac gacgattaaa 701941 ctgtttgaca gagtgcctga agtgcttgaa ttttatcagc gcaaattcca gtacatccac 702001 gttgatgagt atcaggatac gaacagggca caatacatgc tcgttaagca gcttgccgag 702061 cgtttccaga acctttgcgt tgtgggggat tctgatcagt caatctacag atggcgcggc 702121 gcggatatca ccaacattct ttcatttgaa aaagattatc cgaatgcaag cgtgattttg 702181 ctagaacaaa actatcgttc aacgaaacgg attttgcgcg cggctaacga ggtcattaaa 702241 aacaactcta accgcaaacc gaaaaatttg tggacggaaa atgatgaagg catcaagatt 702301 tcctattatc gcggtgataa tgagttcggt gaaggacagt ttgtggccgg caaaattcat 702361 cagcttcaca gcacaggcaa gcggaagctg tcggatatcg ccatattata ccggacaaac 702421 gcgcagtccc gtgtgattga ggaaacgctt ctcaaagcgg gcttgaacta taacattgtc 702481 ggcggcacaa agttctatga cagaaaagaa attaaagaca ttcttgcgta cctgcgcctc 702541 gtatccaatc cggatgacga tatcagtttc acgcgcattg tcaatgtgcc gaagcgcgga 702601 gtcggcgcga catcacttga aaaaatcgct tcgtatgcgg ccataaacgg cttgtccttt 702661 ttccaagcga ttcagcaggt tgattttatc ggcgtcagtg ccaaagcggc aaacgcgctt 702721 gacagcttta gacagatgat tgaaaacctg accaatatgc aggattactt atccattaca 702781 gagctgacag aagaaattct tgataagacg gaatacagag aaatgctgaa ggctgagaaa 702841 tcgatcgaag cccaaagccg tttagaaaat atcgacgagt tcctgtctgt tacgaaaaac 702901 tttgaacaga aaagtgaaga caagacactc gttgcgttcc tgacagactt ggcattgatc 702961 gcagatattg atcagctcga tcagaaggag gaagagtcag gcggcaagga tgcgatcacc 703021 ctgatgacac tgcacgccgc gaaaggactg gagtttccgg ttgttttctt gatggggctt 703081 gaagaaggcg tcttcccgca tagccgttca ctcatggagg aagcggaaat ggaagaagaa 703141 cgccgccttg cgtacgttgg gattacaagg gcggaacagg agctttatct gaccaatgct 703201 aaaatgcgca ccttgtttgg ccggacaaat atgaacccgg aatctcgctt cattgctgaa 703261 ataccggatg atttattgga aaacctaaat gagaaaaaag aaacaagagc gacgtctgcg 703321 agaaaaatgc agccgagacg cggccctgtt tcacgcccgg tatcctacgc cagcaaaaca 703381 ggcggcgaca ccttgaactg ggcagtcgga gataaggcgg gccataaaaa atggggaaca 703441 ggaactgtcg tcagcgtgaa aggcgaagga gaagggacag agcttgatat tgccttcccg 703501 agccctgtcg gcgtgaaacg cctgttagca gcatttgctc ctattgaaaa gcagtaattg 703561 aagaggaaag gaagaagcag atggacaaag aaacagcgaa gcagcgggca gaagaactgc 703621 gccgcaccat caacaagtat agctatgaat attacacctt agatgaaccg agcgtcccag 703681 atgccgaata cgacagattg atgcaggagc tgatcgcgat cgaggaggag cacccagacc 703741 tcagaacgcc tgactctcct acgcagcgcg tcggcggagc cgtgcttgaa gcgtttcaga 703801 aagtcaccca cggcacaccg atgctcagtc tgggcaacgc ctttaatgct gatgatcttc 703861 gtgatttcga ccgccgtgtg cgccagtccg tcggcgacga tgtggcgtat aatgtggagc 703921 tgaaaataga cggtcttgct gtttctctcc gttatgaaga cggctatttt gtcagagggg 703981 ccacaagagg tgacgggacg acgggagagg atatcacgga gaatctgaag acgatccgca 704041 atatccccct taaaatgaac cgtgagctgt cgatcgaagt gcgcggcgag gcgtatatgc 704101 cgaagcgttc gtttgaagca ctcaatgagg aacggattaa aaatgaggaa gaaccgttcg 704161 ccaatccgcg aaatgccgcg gcgggatctc tcagacagct cgatccgaaa attgcagcga 704221 aacgaaacct cgatatcttc gtctacagta tagcggagct tgacgagatg ggtgtagaga 704281 cgcaaagcca agggcttgat tttctcgacg aactcggatt taaaacgaat caggaacgaa 704341 aaaaatgcgg cagcatagaa gaagtcatta cgctgatcga tgagcttcag gcgaagcgcg 704401 cggacctgcc gtacgaaata gacggcattg tcattaaagt cgattctctc gatcaacagg 704461 aggagctcgg ttttacggcg aaaagcccgc gctgggccat cgcgtataag tttcctgctg 704521 aagaggtcgt gacgaagctt ctcgatatcg aattaaatgt cggcagaacg ggtgtgatta 704581 cgccgactgc gattcttgag ccggtaaaag ttgccggcac aacggtctca agagcatccc 704641 ttcataacga agatttaatt aaagagaagg acattcggat tttggataag gttgtcgtca 704701 aaaaagcggg cgatatcatc ccggaagttg tgaatgtcct cgttgaccag cgcacaggag 704761 aagaaaagga attcagcatg ccgacggaat gtcctgaatg cggcagtgaa ctcgtccgga 704821 tcgaaggaga agtggcgctt cgctgcatta accctgaatg tccggcgcaa atccgggaag 704881 ggcttatcca tttcgtttcc cggaatgcca tgaacattga tgggctcggc gaacgagtga 704941 tcacacagct gtttgaggaa aaccttgtcc gcaatgtggc agatttatat aagctgacga 705001 aggaacgagt catccagctc gagcgcatgg gcgaaaagtc cactgaaaac ctgatcagct 705061 ccatccaaaa atcaaaagaa aattcgttag agcgcctgct gtttgggctt ggcatccgtt 705121 ttatcggatc aaaggccgca aagacgcttg ccatgcattt tgaaagcttg gagaacctga 705181 aaaaagcctc taaagaggaa cttctcgcgg tagatgaaat cggtgaaaaa atggctgatg 705241 ctgtgatcac ctattttcat aaagaagaaa tgcttgaact cttgaatgaa cttcaggagc 705301 tgggcgtaaa cacgctctac aaaggcccga aaaaagtaaa agcagaggac agcgactctt 705361 actttgctgg taaaacaatt gttctgacag gaaagctgga agagctgtca agaaacgaag 705421 ccaaagcgca aatcgaagcg ctgggcggaa agctgactgg aagcgtcagc aaaaacacag 705481 acttagtcat cgccggagaa gcggcgggaa gcaagctgac aaaagcacaa gagctgaaca 705541 ttgaagtgtg gaatgaagaa cagttaatgg gagagctaaa gaaataagag gagtgttttc 705601 tattgaaaaa gacgttggca ttggcggcaa cggcggcagt attaatgctg tctgcctgct 705661 cgtcaggttt cgggggggag aaggaggaag agattacgca aaagacggcg aaatcgtcag 705721 aaaaagcgat tgtcccgaaa tataatatct ctgactccta ttacaaaatg gtgctgccgt 705781 ttaaggcagg caaagcgcgc ggcttaacaa cggaacagct gaatacaagg ctggacattg 705841 acgaatttga aacagggctg atgcgccttg cccaagattc tttctcaact gacgattatc 705901 tgttccaaga aggacaatat ttagatgagg atacagtatt aagctggctg gcacggaaaa 705961 aaacgggctc tgatttgaaa aaagccgaaa aagaagataa gaacttcaaa aatgaaggct 706021 tgaacccggc gctcccgagt tctggttcaa cagaagaaaa gaacgaaagc agcccaattt 706081 atttagcatc catgcttgag cacgattatt tagtcagaaa agacaagaat tctatccagc 706141 ttggcggcgt catgatcgga ctggcgttaa actcagtgta ttactatcgt gaaaaaactg 706201 gcgacccgca aaaagaagtg gagattaaag acagcacgct tcgccagcag ggagaaaaaa 706261 ttgcacagga ggttattaac cgcctccgca aaaaagataa cttgaagaat gtgccgatta 706321 ccgtggcgct ctacaagcag gcgtcaaaaa catcgattgt gccggggaac ttcatcgcca 706381 aaacagaggt caaagcaggc tctactgata tctcaaattg ggatgacatc aatgaaaaat 706441 atgtattcta tccggcggat acaaccacag cagaaaagta cccggatgac accgaggtct 706501 ttaagcggtt caaaaactca attgaagaat atttcccgaa ctatacaggc gttgtcggta 706561 cagcgctgta tgaaaatgat gaaatgaaga aaatgaagat tgacatacca atgcaattct 706621 acggaaaaag tgaagttgtc gcgtttaccc agttcttaac gggtgaagtg atggactact 706681 actctaagag ctcagttgat gtcgaagtca atatcacgtc ctcagacgga caggaagcgg 706741 tcattatccg caatgccgga gataaagagc cgactgttca catttatgac tgatagaaaa 706801 cccttgtgcc atattggcac aagggttttt atgttacaat taacaggaaa agggaaaata 706861 ttttcacttc tgccgaaaca caaatcaagg ggaggtatgt tgatgctgga aatcgtgtga 706921 aaacaatcat tatcaaatct atagcaatga aaggatgtta gacgtgcata aagatatcaa 706981 aaaaatattt catgaagagc aggttttggc agaagctgca gcgagatacg gtttctcaaa 707041 agatcaggtg cgttttctgg ctgatgcgga aaactatgta tatgaatgta tgaaagacaa 707101 tcaaccttat attttaaaga ttacccatac gattcggaga tcttctgatt atatgatggg 707161 agagatggaa tggctccgtc accttgcaat agggggaatt tcagtagcca aaccgctccc 707221 gtcgctgaac ggaaaagacg tagaagcagt gccggacgga aacggcgggt catttttatt 707281 gagagtgtat gagaaagcgc cggggcaaaa agtggatgaa tcggactgga atgaaacgct 707341 attttatgag cttggcagat acacaggcag catgcacagc ctgacaaaaa gctacaaatt 707401 gagcaatccc gctttcaaaa gacaggaatg ggatgaagag gagcaattaa agctgagaaa 707461 atatgtgcct gaagatcaga taaaggtgtt tcagcaagcc gattctttga tgaatgaact 707521 gcggaggctc ccgaaaagcc aggacaacta cggcttggtg catgcggatc tgcaccatgg 707581 caattttaac tgggatcatg gcaaaatcac ggcatttgat tttgatgata tcggctacaa 707641 ctggtttgtt aacgatatta gcattcttct ctacaatgtc ctgtggtatc ctgttgtgcc 707701 atatgatgat aaagctgcgt ttacagaaga atttatgacg cattttatga aagggtactg 707761 ggaggaaaat gagcttgacc ctgcatggct gatgataata cctgatttcc tccgccttcg 707821 ccatatgctg atttacggat tgctgcatca gatgtttgac cttaacacaa taggagaaga 707881 ggaaaaagaa atgctggccg gtttcagaag agatatagag aatggcacgc cgattacagc 707941 atttgatttt tcagcactgg tgtagataga aaaagccaat gggattccag tcccattggc 708001 ttttataatg tatcacactt cacgccgact acgccttcaa tggctttaat gtcatagtag 708061 acatcggtcg tgtatctgtt tttatggacg cggaccttca cttccataat tggaaaatcc 708121 ttttcgccta ggtcgtcgat ccgaacggag tgtgctttga tatctcttct tttcatttct 708181 tttaaaatct ctgtcatttt gtctttatca gaaagtgaca ttctgatgcg gatgtctttt 708241 tcctgcaggc ggtcggggcc gatttttctg accacccatg ggagaaattc cacactgatc 708301 aggatgaaca gaagactggc aaacgcttct ttataaaaac cggctcccgt agcaagcccg 708361 agccccgctg ccccccagat catggccgat gtcgtcaggc cggaaatgac atcattgctt 708421 tttcgcagga tgacaccggc gccgataaac ccgacgccgg agatgatttg tgccggcaga 708481 cgaagcggat ccatcatgat gcggtagtat ttagggaaat gatatgccgc attaatactg 708541 acgatcgtca gcatgcatga gctgactgcg atgacaatac aggtttttaa tccgagcggc 708601 ttatttttta attcgcgttc aagcccgatg accatgccaa tcaatgtggc aatgcccaat 708661 ttcaataaaa tatcaggatc aatataccag ctcaacagca aacttccccc ttctctatgg 708721 tgtttttaaa taaatatgat tttctcacag tatttatagc aaaacaagag cacaaaagcc 708781 accaagctgc gcttgatggc ttattgctta ctttttgcgt tttaacagct tttccatgac 708841 accgaataat cggtaagagg cttttgcagg acgttttgtg atcatgctga caatgatgcc 708901 ggcaatcata ctgagaataa acccagggat gatttcgtac acaccggttg attttgccag 708961 gccggttgta atccagatca acacggtcgc agccccgaca atcatggcag caagcgcgcc 709021 ccattcgttc attcgtttcc aatacagact gagcagaatc gcaggcccga aagctgaacc 709081 gaagccggcc caagcgtatc cgaccaaatc aagaatggtg ctgttcgggt tcaatgacaa 709141 gagtaccgcg ataacggcaa tgactaagac ggacaatcgc ccgatcatga ccaattcttt 709201 atcagaagct tttcgtctga aaaatgaccg gtataaatcc tctgttacag cacttgctgt 709261 gaccaagagc tgtgaggaaa tcgaactcat gatggcagcc aaaatagctg acaataagaa 709321 ccctgtaatt aatgggtgga acaagatttt agagaagata atgaaaatca tctccggatc 709381 ttttacagca actccgaatt tatgggcgta tgcaacaccg attaaacccg tcagcacgga 709441 acctagaact gtaatgatca tccagctcat gccgattcgg cgtgcaggtt ttaaatcttt 709501 aatgtcttta atggccataa atcggacgat gatatgaggc tggccgtagt agcccaaccc 709561 ccaggctaaa taggaaataa tgctaatgac gctcgcgcct ttaaaaatat ccaataaatg 709621 tggattaaca gcgtcgattt catggaaagt cggagcaacg ccgcccacat gggtaaaagc 709681 aacgatcggc acaagcacta gtgctgcaaa catgatcgca ccctgcacga agtcagtcag 709741 actgacagca aggaaaccgc caaacagtgt gtataacacg acaactgcgg tggtcagaaa 709801 caggcctaat ttgtaatccg caccaaaagc agattcaaac agccgtccgc cagataccat 709861 accggaagag gtatacaatg tgaaaaagat catgatgatc aatgcagata cgattttcag 709921 cagtgatgaa gaatgctgga atcgtttatc aaagaaatca ggaattgtaa tcgcatcatc 709981 tgccgcttct gtataagcac gcagccttgg agccagcagc aagtaatttg agtacgcccc 710041 gattgtaaga cctaaagcaa gccataaggt ggacagccct gtcgcaaaca tcgcgccggg 710101 aacacccatc agcatccatc cgctcatatc ggccgcgccg gcagacaaag cagtaacgaa 710161 tggtccgagg cctcttcctc caagcatgta atcattgatg tcagtggttt tcttgaatgc 710221 ataccagccg attaacagca tggcaataaa gtaaattcct aaagatataa taatttcaat 710281 actcacgttt taccctctct tcatttctaa taatgttgca tcacctctca aattgatggt 710341 gccagttaag cagcctggcg taagtgcaaa acaaaagaaa ttcttttgcg ggtgcacttg 710401 gtaacttaac ctaacaaagt attcccggcc attcaagcga tgaaacattg atcataagct 710461 ggaaataccg ttgcaaacct agaagggaat aaagaataaa acgctttcaa aaaataatta 710521 aagtaaaaat attcagaaaa atatttcgtt tctccttctc ctcattttag tataaaatat 710581 atagggtatt gtttcgaaaa cacaggcctg tctcaaggcg ttttgttgct ttaaagggct 710641 tgtttttgat atgatcagta ttatatgact taacggagaa atatgtggag gtggatcata 710701 tgtcacgaat ttcaatagaa gaagtaaagc acgttgcgca ccttgcaaga cttgcgatta 710761 ctgaagaaga agcaaaaatg ttcactgaac agctcgacag tatcatttca tttgccgagg 710821 agcttaatga ggttaacaca gacaatgtgg agcctacaac tcacgtgctg aaaatgaaaa 710881 atgtcatgag agaagatgaa gcgggtaaag gtcttccggt tgaggatgtc atgaaaaatg 710941 cgcctgacca taaagacggc tatattcgtg tgccatcaat tctggactaa aggagggaca 711001 caagaatgtc attatttgat cataaaatca cagaattaaa acagctcata cataaaaaag 711061 agattaagat ttctgatctg gttgatgaat cttataaacg catccaagcg gttgatgata 711121 aggtacaagc ctttttggca ttagatgaag aaagagcgcg cgcatacgcg aaggagcttg 711181 atgaggcggt tgacggccgt tctgagcacg gtcttctttt cggtatgccg atcggcgtaa 711241 aagataatat cgtaacaaaa gggctgcgca caacatgctc cagcaaaatt ctcgaaaact 711301 ttgatccgat ttacgatgct actgtcgttc agcgccttca agacgctgaa gcggtcacaa 711361 tcggaaaact gaacatggac gaattcgcca tggggtcatc tacagaaaac tcagcttaca 711421 agctgacgaa aaacccttgg aacctggata cagttcccgg cggttcaagc ggcggatctg 711481 cagctgcggt tgctgcggga gaagttccgt tttctcttgg atctgacaca ggcggctcca 711541 tccgtcagcc ggcatctttc tgcggcgttg tcggattaaa acctacatac ggacgtgtat 711601 ctcgttacgg cctggtcgca tttgcgtctt cattggacca aatcggaccg attacacgta 711661 cggttgagga taacgcgttt ttacttcaag cgatttccgg cgtagacaaa atggactcta 711721 cgagtgcaaa tgtggacgtg cctgattttc tttcttcatt aactggcgac atcaaaggac 711781 tgaaaatcgc cgttccgaaa gaataccttg gtgaaggtgt cggcaaagaa gcgagagaat 711841 ctgtcttggc agcgctgaaa gtccttgaag gtctcggcgc tacatgggaa gaagtgtctc 711901 ttccgcacag taaatacgcg cttgcgacat attacctgct gtcatcttct gaagcgtcag 711961 cgaaccttgc acgctttgac ggcatccgct acggctaccg cacagacaac gcggataacc 712021 tgatcgacct ttacaagcaa acgcgcgctg aaggtttcgg aaatgaagtc aaacgccgca 712081 tcatgctcgg aacgtttgct ttaagctcag gctactacga tgcgtactac aaaaaagcgc 712141 aaaaagtgcg tacgttgatt aagaaggatt tcgaggacgt atttgaaaaa tatgatgtta 712201 ttgttggacc gactacaccg acacctgcgt ttaaaatcgg tgaaaacacg aaggatccgc 712261 tcacaatgta cgcaaacgat atcttaacga ttccggtcaa ccttgccggc gtaccgggaa 712321 tcagtgtgcc atgcggatta gcagacggac ttccgctcgg cctgcaaatc atcggaaaac 712381 actttgatga aagcactgta taccgcgttg ctcatgcatt tgaacaagca acagaccatc 712441 ataaagcaaa acctgaactg taaggggtga aaagaattga actttgaaac ggtaatcgga 712501 cttgaagtcc acgttgagtt aaaaacaaaa tcaaaaattt tctcaagctc tccaacgcca 712561 ttcggcgcgg aggcgaatac gcagacaagc gttattgacc tcggatatcc gggcgtcctg 712621 cctgttctga acaaagaagc cgttgaattc gcaatgaaag ccgctatggc gctcaactgt 712681 gagatcgcaa cggatacgaa gtttgaccgc aaaaactatt tctatcctga caacccgaaa 712741 gcgtatcaga tttctcaatt tgataagcca atcggcgaaa acggctggat cgaaattgaa 712801 gtcggcggca aaacaaaacg catcggcatc acgcgccttc atcttgaaga ggatgccgga 712861 aaactgacgc atacgggcga cggctattct cttgttgact tcaaccgtca aggaacgccg 712921 cttgttgaga tcgtatcaga gccggacatc cgcacgccgg aagaagcgta cgcatatctt 712981 gaaaagctga aatccatcat ccaatataca ggcgtttctg actgtaaaat ggaagaaggc 713041 tcacttcgct gtgacgccaa tatctctctt cgtccgatcg gccaagagga attcggcaca 713101 aaaacagaat tgaaaaactt gaactccttt gcgtttgttc aaaaaggcct tgagcatgaa 713161 gaaaaacgcc aggagcaggt tcttctttcc ggcggcgtca tccagcaaga aactcgccgt 713221 tatgatgaag caacgaagaa aaccattctt atgcgtgtca aagagggatc tgacgactac 713281 cgttacttcc cagagccaga tctagtcgag ctctacattg atgatgaatg gaaggaacgc 713341 gtaaaagcaa gcattcctga gcttccggat gagcgccgca agcgttatat cgaagagctt 713401 ggcttgcctg catatgacgc aatggttctg acgctgacaa aagaaatggc tgatttcttc 713461 gaagaaaccg ttcaaaaagg cgctgaagct aaacaagcgt ctaactggct gatgggtgaa 713521 gtgtcagctt acctaaacgc agaacaaaaa gagcttgccg atgttgccct gacacctgaa 713581 ggccttgccg gcatgatcaa attgattgaa aaaggaacca tttcttctaa gatcgcgaag 713641 aaagtgttta aagaattgat tgaaaaaggc ggcgacgctg agaagattgt gaaagagaaa 713701 ggccttgttc agatttctga cgaaggcgtg cttctgaagc ttgtcactga ggcgcttgac 713761 aacaatcctc aatcaatcga agactttaaa aacggaaaag accgcgcgat cggcttccta 713821 gtcggacaga ttatgaaagc gtccaaagga caagccaacc cgccgatggt caacaaaatt 713881 ctgcttgaag aaattaaaaa acgctaataa aaaagcagcc cttagaggct gcttttttta 713941 tggtcaaatt gagataaaga caagatgagg gcccgaagcc tttcaacttc tttgtcgttg 714001 gttccggcca aattggacag catgccttta ataatcggct tgcgcggttt atcctgagtc 714061 aattcttcct cgataacatc aagtgacacg gtgatatcct cgggcagcgt gctgttttct 714121 ttcactttct gaatgtcctc aagcagctgg tcttttcccg caggcatcgg gttaaaaatg 714181 tcttttgata caatcggatt gagtgcagaa cggctcagcc cctgtacaag atcatccagt 714241 ctctcaataa taaaggctga gatttcttct gcatcgatat taagctcacc gttaaatacc 714301 atcacgttca tataggaatg cacaatgcct cttgccatga tggacagatc tgcgacatac 714361 cgctcgattc cttcgccata ggataccagc aaggcgttcc ggtacagctt atccgtctcc 714421 atggttactt tgtaaaagta ttgcttgatt tcttgatttt ccggaatgat attttcggta 714481 agcaaaagaa cgataaaatc tttatgatcg cgaaaatcct caaattgagc gccaatttgc 714541 ttttttaaca cttccttagg cggctttccg gcgagatctt cttctatatt tttcattttg 714601 ttcatagaca taccgatata atattcacag gcagataaca gcagcgcttc tttcgatttg 714661 aagtgcaaat aaaaagcgcc cttcgaaatg ccgcattcac tggcgatttc ttggatcgtc 714721 gtagctgcga atcctttttt cgcaaataaa cgaatgctgg tttttatgat tctctctttt 714781 ttttcattca tgacgtgctt ccccttaatc cttgaaaaat ttagtaaaat tttctggtat 714841 atgagttgac gttgttgcgt tataacgttt agtattatat agaatgacca gtcagtcaat 714901 aaaaaatgta atggaggata tgatgaacca cgttattaat ttcgttctga aaaacaaatt 714961 cgccgtatgg ctgatgacga ttattgtaac ggcagccggc ttgtatgcgg gtatgaatat 715021 gaagcaagag tctattcctg acgtgaacat gccttacttg acgatcagca cgacatatcc 715081 gggtgcaaca ccaagccaag tggctgatga agtgaccaaa ccggttgaac aagccgtaca 715141 gaacttggac ggtgtcagcg ttgtgacgtc gacgtcctat gaaaacgcat cgtcggtcat 715201 gattgaatat gattatgaga aagatatgga caaagcgaaa acagaagcag ctgaagcgtt 715261 agaaaacgtc aacctgcctg atgacgcgaa ggatccggag atttcacgct acagcttgaa 715321 ctcattcccg attctgacgc tgagcgtgtc cagtgataaa gataatctgc aagagctgac 715381 gaaacaagtg gaggacagcc tcgtttctaa gcttgaaggc atagaaggcg ttgcgtccgt 715441 ccaagtatca ggccagcagg tggaagaggt tgaattctct ttcaaagaag acaaactgaa 715501 ggaatacggc cttgatgaag atacagtcaa gcaagtgatt caaggttcag atgtgacaac 715561 tccgcttgga ttgtacacat tcggaaatga agaaaaatct gtcgtcgtca gcggcgatat 715621 tgaaacaatt aaagatttga agaatatgag aatcccgacg gcatctgctt caagtgcagg 715681 cagcagcgca gcatctcaag caggtgcgca gagtgctcaa gcagcccaaa gcgcgcaagc 715741 ggcagcacag gtgcagcaaa gcgcaagcac agcagtgccg acggtcaagc tttctgacat 715801 tgctacaatt aaagatgtga aaaaagctga atccgtttca cgcacaaatg gcaaagacag 715861 catcggcatc aacatcgtca aagcaaacga tgcgaatacg gtagaggttg ccgacgatgt 715921 caaagctgag ctgaaaaagt tcaaagaaga ccataaaggc ttcaattaca gcgcaactct 715981 cgacatggcg gagccgatca cacagtcagt tgacacgatg ttaagcaaag ccatcttcgg 716041 tgctattttt gcgattgtga ttattctctt attcttaaga gatatcaaat caacattaat 716101 ttctgttgtt tcaattccat tatcattgct gatcgcactc cttgtgctgc agcagcttga 716161 tatcacattg aatattatga cgctcggcgc aatgaccgtt gccatcggac gtgtagtcga 716221 tgactccatc gttgtgatcg agaacattta ccgccgcatg agactcaaag atgagccgct 716281 ccgcggaaaa gccttggttc gtgaagcgac gaaggaaatg tttaaaccga tcatgtcatc 716341 aacgattgtg acaatcgcgg tattcctgcc gctcgcactt gtaggcggac aaatcggtga 716401 attgtttatt ccatttgcct taacgattgt ttttgcgctt gccgcatccc tagtgatttc 716461 aatcacgctt gtgccgatgc tcgcacacag cctgttcaaa aaatcattaa ccggtgcgcc 716521 gattaaagcg aaagaacaca aacctggcag acttgcaaac atctataaaa aagtattgaa 716581 ctgggcgctg agccacaaat ggatcacgtc tatcatcgcg gttctgatgc tccttggaag 716641 cttgttcctc gtaccgttaa tcggtgccag ctacctgccg tccgaggaag aaaaaacgat 716701 gcagctcaca tacagcccag aaccgggtga aacgaaaaaa gaagccgaaa atgaagctga 716761 aaaagcggaa aaaatcctgc ttgaccgcaa gcatgtcgat acggttcagt attcattagg 716821 ctctggcagc ccgcttgccg gaggagattc taacggtgcg ttattctata tcaaatatga 716881 aagcgacaca cctgactttg ataaagaaaa agataacgtt ctgaaggaaa tccaaaagca 716941 atctgaccgc ggagaatgga agtcacagga cttcagctct tcaggcaata ataacgaatt 717001 aacatactat gtgtatggcg attctgaaaa cgatattaaa gacacggtca aagacattga 717061 aaaaatcatg aaagatgaaa aggatctgaa aaacgtaaat tcaggccttt ccagcacata 717121 tgatgagtac acatttgtcg ctgaccaaga aaaactaagc aagctcggtt taaccgcgtc 717181 tcaaatttct caggccttaa tgtcacaaac atcgcaagaa ccgctcacca ctgtgaaaaa 717241 agacggcaaa gagcttgatg tgaacattaa gacagaaaaa gacgagtata agagtgtgaa 717301 agatttagag aataaaaaga tcacttccgc gactggccag gaagtcaaaa tcggcgatgt 717361 ggcaaaagtg aaagaaggat caacatcaga taccgtgtca aaacgtgacg gaaaagtcta 717421 tgcagatgtc acaggtgagg ttacctctga caacgtcaca gccgtatcag ctgctatcca 717481 gaagaaaatc gataagcttg accaccctga taacgtatcg attgacacag gcggcgtatc 717541 agcggatatc gctgattcct tcacgaagct cggtttagcg atgctggcag caatagcgat 717601 cgtttacctt gtgctcgtga ttaccttcgg cggagcacta gcgccatttg cgattctgtt 717661 ctcattgccg ttcacagtca tcggtgccct ggtcggactt tacgtatcag gtgaaacgat 717721 cagtctgaac gccatgatcg gtatgctcat gctgatcggt atcgttgtca cgaatgccat 717781 tgtcttaatt gaccgcgtga ttcataagga agcggaaggc ctgtctacga gagaagcgct 717841 cctggaagcc ggctctacac gactccgtcc gatcctgatg acagccattg cgacaatcgg 717901 cgccttgatt ccattagccc tcggcttcga aggcggaagc caggtcattt caaaaggact 717961 cggcgtaacg gttatcggcg gtttaatcag ttcaacgctt ctgacgctcc tgatcgtgcc 718021 aatcgtatat gaagtattgg cgaagttccg caagaaaaaa ccgggaacgg aagaagagta 718081 aaaaacaaaa agcctcagct ctgctgaggc tttcagcttg ttgaaaaacc ctcgcattcg 718141 ttgtcaggtc tgcgcgtcgg tgctcacgaa ttctacattc gctccgctcc aatgctcccc 718201 cttcctagac tacaagggtt ttcaatcaag ctgaaagaat gttaaggatg acaaaagctc 718261 aaaacaagaa tcagttttga gcttttgtgc gttttcacct gtaagattat gtacattttg 718321 ttgcgatttt tttaactcat agtataatta aaggttgtta gtgtaaaaat ggatcggata 718381 ctcttaagta ggatgatgag ataatgaaac gtgcacgcat aatatacaat ccgacttcag 718441 gacgggagat ctttaaaaag catcttgccc aggtcctgca aaaatttgaa caagccggct 718501 atgaaacctc cacccatgcg acgacatgcg caggagacgc tacacacgct gccaaggaag 718561 cggcattgcg tgagtttgac ctgatcattg cggcaggcgg agacggaacg atcaacgagg 718621 tcgtcaacgg gcttgcgcct ttagacaatc gtccgacact cggtgtgatt cctgtcggca 718681 caacgaacga cttcgccaga gcgctcggaa tcccacgcga ggatatttta aaagcggcag 718741 atacggtcat taacggcgtt gcccgcccga ttgatatcgg acaggtcaac ggccagtatt 718801 ttatcaatat cgccggcgga ggccgtctga cggagctgac gtacgacgtg ccaagcaaac 718861 tgaaaacaat gctcggccag cttgcttatt atttaaaagg aatggaaatg ctgccttcac 718921 ttcgtccgac agaagtcgag attgaatatg acggcaagct gtttcaaggt gaaatcatgc 718981 tgtttttggt cacgctgaca aactccgtcg gcgggttcga aaagctcgcg ccggattcca 719041 gcctgaatga cggcatgttt gatttgatga tactaaagaa agcaaacctt gctgaattta 719101 tcagggtcgc cacgatggcg cttcgcggag aacacatcaa cgaccagcac attatttata 719161 caaaagcgaa ccgcgtgaaa gtcaatgtat cagaaaagat gcagctgaac ctggacggcg 719221 agtacggcgg catgctgccg ggcgaattcg tgaatctgta ccggcacatt cacgtcgtca 719281 tgccgaagga gaaagcggaa cagttggatg actaaaactt ggcttggtaa gccaagctca 719341 gaatgttgac aaaatcctaa aacagttttc gttttaggat tttgtcatct tttcagcgtg 719401 attgaaaacc tttgaagtct aggaagggcg agcatcggag cacagcgaat gttgaattcg 719461 tgagcaccga agcacaggcc tgacaacgaa tgcgaaggtt tgcctacacg ctgaaacttg 719521 gcttgaatag gccaagtttt tctttcgctt aaaactagag gtgattatag atgaaaatga 719581 aacccccagt agaaaaaaat gaatactacg atgtgacatt tgaggatttg acacatgaag 719641 gagcgggcgt cgcaaaggtc caaggcttcc cgatctttgt gccgaatgcc ctacccgagg 719701 aaaaagccca aatcaaagtg acacgcgtca aaaaagggtt cgccttcggc cgcctgattg 719761 agctgaagga agaaagcccg catagaacgg acgccccatg cccgatttac aaacaatgcg 719821 gaggctgcca gcttcagcac atgacctacg aaggccagct cctgtttaaa cagaaacaag 719881 tcaaagacgt cttagaacgc atcggcaagc tggacctttc aaaagtcacc gtgcacccga 719941 cactcggcat ggaagacccg tggaactaca gaaacaaagc acaggtgccg gtaggagaac 720001 gggaaggcgg actcgtcgcg ggattctatc agcaaagaag ccatgacatc atcgacatga 720061 gcgcctgcct gatccagcaa tccaaaaacg acgaagccgt tcaagctgtc aaagacattt 720121 gcgcaaacta cggtgtcaaa gcctacaacg aagaacgcca caaaggctgg ctccgccaca 720181 tcatggtcag atacggcgtt gttacgggcg aaatgatgat cgtcttcatc acaagaacaa 720241 gcgacttccc gcacaaagcg aagatcatcg aagacatcac agcgcaattc ccgcacgtca 720301 aatccatcgt gcaaaacatc aacccaaaca aaacaaacgt catttttggc aacgaaacaa 720361 acgtcatctg gggcgaagaa tacatctacg acctcatcgg agacgtcaaa ttcgccatct 720421 ccgccagatc gttttatcag gtcaacccag agcaaacaaa agtgctctac gacaaagcgc 720481 ttgagtacgc tgagcttcaa ggggaagaaa ccgtcatcga cgcttactgc ggcatcggaa 720541 cgatttctct cttcctggca aagcaggcga aaaaagtgta cggtgtagag attgtgccgg 720601 aagcaattga ggacgcgaag cgaaacgccg aattaaacgg caacacaaac gcagagtttg 720661 ctgttggaga agcggaaacc gtgattccaa agtggtacga agaaggcatt acagctgata 720721 cgctggtcgt cgacccgcca agaaaaggct gcgacgaagc cctcctgcgg acaattgtgg 720781 agatgaagcc gaagcgggta gtgtatgtgt cctgtaatcc tggcacgctt gcgagagatt 720841 tgcgggtgct tgaggatggc gggtacgtga cgcgcgaagt gcagcctgtg gatatgtttc 720901 cgcatacgaa tcatgtggag tgctgtgtgt tgataaaatt aaaagaataa atagtcaaaa 720961 atctatgctg atggaactgt tggttctcta aaacgataat tgatttcaat ggttccattt 721021 gcatgtactt ctatttcatc tactaacaaa tgaagcattt cgggggtaag tgtaccttcc 721081 ttcatgaatt tatctaagct ctttttaaaa tcaattattt ctttttcaat cttttgaaat 721141 tctaggtcct tagatagttg gtgaagggta gtttcaaaat ttgaaatatc ttcattggtg 721201 atatttatgg ctaattggta atcttcttta gatataacac cattagcaag agagataact 721261 aaattggatt tatctctctt tttatcgttt aatttttcat taatttcgat tatcttagat 721321 tcgatttttt ctttgtactt taacgctttt tcacttaatt ctttaaaata attttcctta 721381 ctgaatttca aatatatctt atttaggttg gttattactt tatcagttaa atctatttca 721441 cttacgtaat gatcactaca tgcttttaaa ccatgtttat tataacttcc acaaacataa 721501 ccttttcgat tctttttaaa atgcattgac ctcctgcaat ctttgcaaac cgcagtattt 721561 gtaaagagat gtacttcagc ttgaggtctc cttctttttc tagttattaa aatctcttgt 721621 acaataagaa agtcttctaa aggtatgatt ggttcgtggc ttttttcaat aattatttgg 721681 ttttctaggt taactgacct tcttctttta ctggtaacac tcggtctata ttctctacat 721741 tgttgtagtg tcccagtata gtgaggattt tcgagaattt ttcttattga agatccgtgc 721801 catttgtcag tagcgttctt tttgcgggca agctgcgagg gactagtgac cccttcgtta 721861 tacaatcccc ttgctattgc atcaaagcct tttccagcaa tatattctga aaagattcta 721921 atatttacta ttttctctgc gtttgctgaa tttgagagag atatgattgt agaacgaact 721981 caagaaggta aaatgttggc caagcagaat ccggatttcc gagaaggaag acccaaaaag 722041 ttcacaaagc agcaaatcaa tcatgcatta acattactag aaaatcattc gtataaacaa 722101 gttgaagata tgactgggat atcagtttct acacttgtaa gagctaaaaa gaagaaagct 722161 gctgaagcta taaatggata aatattgtga attaattatt caatatcttg agaaattttt 722221 ataaaagtaa tcaaaagttt aatgggggaa acgaaatggc gctcattgat ttagaagata 722281 aaattgctga aatagtgaat cgagaagatc attcagattt cttgtatgaa ttactcggtg 722341 tatatgatgt tccacgagct acaattacgc gcttgaaaaa aggaaatcaa aaccttacaa 722401 aacgggttgg tgaagtacac ttaaagaata aggtgtggtt taaggaggct aagaaaggaa 722461 agctctttga cgcccttatt gatatagaac aacaagttga atatctttca gctaagccac 722521 gatatttatt agttactgac tatgatggag tattagcgaa agatacaaaa acattagagg 722581 ctcttgatgt taaatttgaa gaacttcctc agtatttcga tttcttcctt gcttggaaag 722641 gtattgagaa agtagagttt gaaaaggaaa accccgctga tattaaagca gccgaacgtt 722701 ttgcacggat atatgatgta cttcgtaaag aaaacaatat tattgagact aatagagggt 722761 tagatttatt tcttattcgt ttactgtttt gttttttcgc agaagatact gacatcttca 722821 aacgaaatag ttttacgaat ttaattaaga ctttgactga agaagatggt tcaaatctaa 722881 ataaattatt tgctgattta tttatcgtgt tagataaaaa tgaacgagac gatgttccat 722941 cttatttaaa agagtttccg tatgtaaatg gccagttgtt tactgaacca catacagagt 723001 tggaattttc tgccaaatcc agaaagttaa ttattgagtg cggtgaatta ttaaactggg 723061 ctaaaatcaa tcctgatatc tttggttcaa tgattcaagc tgttgcttct gaagaaagcc 723121 gtagttattt aggtatgcac tacacaagtg tccccaatat aatgaaggtt attaaaccgc 723181 ttttcctaga taaacttaat cagtcttttt tagatgcata cgatgattat acaaaacttg 723241 aaaatcttct aacacgaatc ggcaaaatta aattctttga tcctgcatgt ggttcaggga 723301 actttttgat tattacctac aaagaattac ggcgtatgga aatcaatatt ataaaacgac 723361 ttcaagaact cttgggagag tatctttatg taccttcagt aactttatct caattttacg 723421 gaatagagat tgaagatttt gcacatgacg ttgcaaaatt atcactttgg attgctgaac 723481 atcaaatgaa tgaagaatta aaaaatgaag ttcataatgc agtacgccca acgttaccac 723541 ttcatacagc aggggatatt cgttgtgcaa atgctattag ggttgagtgg actgaggttt 723601 gtcccgcaca aggatctgaa gaagtatatg tttttggtaa tccaccgtat cttggttcaa 723661 aaaaacaaaa caaagaacat aaatctgata tgttatcaat ttttggaaaa gtcaagaatg 723721 gtaaaatgct tgattatatt tctgcttggt tttactttgg tgctaaatac gcttcaacta 723781 caaatgcaaa agttgccttt gtatcaacaa attcagttac tcaaggggaa caggtttcta 723841 tcttatggaa tgagttattc aagtttggaa ttcaaatcaa ttttgcctat aaatctttta 723901 aatgggcgaa taatgctaaa aataatgctg cggtaattgt tgtgattgta ggttttggcc 723961 cgttagatac caaagtaaac aagtatttat ttgttgatga aacgaaaaag ctagtttcta 724021 acattagtcc ctatttaact gatggtgaaa atattcttgt ttcttctagg acgaagccaa 724081 tttcagactt acccaaactg cattttggga acatgcctaa tgatggcgga ggattactct 724141 ttaccattac ggaatataca gacgcaatca ataagtatcc tgaattagtt ccctatttta 724201 aaaagtttat aggttcagta gagtttatta atggtggttt acggtattgt ttatggctta 724261 atgaagcaaa atatgaaaaa ataaagtcta atcctctaat acaagaaaga atctcaattt 724321 caaaaaatca cagggaaaaa tcaacagata aaggaacgaa taaacttgca ttaactccgt 724381 ggaagtttag agatactcat gaaacaacta attattccat tgttgttcca tctgtgtctt 724441 ctgaaaatag attttatatt ccaatgggat tagcaggtgc agatacaatt ttgtcaaatc 724501 taatttatgt aatttacgat gcagaaattt accttctagg cattttgatg tcacggatgc 724561 atatgacttg ggtaaaagct gtagccggaa gattaaaaac tgactatagg tactctgcag 724621 gtttatgtta taacactttc cctattcctg aattatcaac aagaaggaag aatgaaattg 724681 aagaagcaat tcttgaaatt cttgatcttc gtgaagagca gggtggtaca ttagcagagc 724741 tttataaccc ttcaacaatg ccaattgaat taaaagtagc acatgaaaag ttggatggaa 724801 ttgtagaaag agcgtatcgt caaaaacaat ttgaatctga tgaagaacgc ttagaagtat 724861 tgcttaaatt gtatcaagaa atgacagaac ggtaggtgta aggtgtatgg aaaatataat 724921 tgaaattaat tataaccaaa ctggtaaaag taagaaaaca aatgaatacg gtatgcgtga 724981 aatgcaggca agagcttttg aaaaacgtaa ctcacaatat ctcttagtta aagcaccgcc 725041 agcttctggg aaatctagag ctttaatgtt tatcggtttg gataagctca taaatcaagg 725101 tttgaggaaa gtgattgttg ctgtacctga acgctctata ggttcttcat ttaaaaatac 725161 ggatttaaaa agttatggtt tctttgaaaa ttggaaagtt gatcctagaa ataatttaac 725221 tgttggcgga gataactcta aggttaaatc ttttgttcgt tttatggaat cggacgatca 725281 ggtgttaata tgtacgcact ctactttgcg atttgcgttt gaaaaaattg atgataaagc 725341 atttgataat tgtttacttg caatagatga atttcaccat gtatcggcag atgtcaattc 725401 tcgattaggt gaattgttaa gaagtattat tcataattca tcagcacata ttgtagcgat 725461 gactgggtcg tatttccgtg gagattctgt accaatttta ttaccagaag atgaggaatt 725521 atttgacaag gtaacttatt cctattatga acaacttgat ggatatgaat atctaaaggg 725581 atttggtata ggatatcact tctatcaagg ccagtacaca tcagctatta atgaagtatt 725641 ggatacaaat aagaaaacaa tcgttcatat tccaaatgta aactcagggg aatcgacaaa 725701 ggataagtac gatgaagttg gtaagatact tgatatgatt ggtgaagttg aatatcaaga 725761 tgatgatact ggaattattt atgttaagcg acattctgac ggtaaaacat tgaaaattgc 725821 agatttagta gatgaccaag ttggaagaga aaatgtcgtt gcgtatttgc gtaatattga 725881 agccctagac gatttagata taattattgc tcttggtatg gcgaaagagg gctttgactg 725941 gccgttttgt gaacatactt tgacagttgg ttatcgtggc tcacttacag aaatagtaca 726001 aataattggg cgctgtacac gtgatagtta caataaaacc tatgctcaat ttaccaacct 726061 aatcgcaatg cctgatgcaa aggatgaagt agtgacttat acagtgaata caatgcttaa 726121 agctatttct gcctcacttt tgatggagca ggtccttaca cctgacttta aatttaaacg 726181 tagaagaaat gaaagtgaaa aatcttctac tacaggagaa ttattcgtta agggattgaa 726241 agaaccatca acagaaaatg tcaaaaagat tattgaaaat gatattaatg atttaaaagc 726301 aaaaatcatg caagattcac aagtccaaaa aacatttagt ggagaagtag atcccaaagt 726361 attgaacaaa gtgttgattc cgaaagttat tcaaaaagta tatccaaatt tatcagatga 726421 ggaaattgag gaagttagac agcacgttgt tctagataca gttatgaaag gtgctaagtc 726481 tgaagttgta ggaagtaaag aatttataag aatggcagat aagtttataa acattgagga 726541 tttagatatc aatctgattg attccatcaa tccgttccaa aaagcatttg aggttctatc 726601 gaaagaattg aactcaccag tgctaaaact gattcaggaa actattgatg caaaacgtat 726661 taattttgat gaagatgaac tagtattcat atggccaaag gtttaggaat tttatcgttc 726721 aactggtaga agacctgatt caaaatctga agacccactt gaaaggcgta tgggtgaagc 726781 tgtattatac atgcaagagc ttaggaggaa acgtgaaaat ggcaagtaat agataccatt 726841 ctattaatga aatcatggaa agtcagctgt tttaccaaat cacaacacca cctaagaaaa 726901 cacaaaaagc ccagtatgat cctgaagttg aaaagttttt ggagattatt gaattcgtca 726961 aagaaaatgg gcgagaaccc caaaaagtcc ctactgattt aactgaaaga agtttagcaa 727021 gtcgattaat tgggattcgg aaagatcctg atcgtatgga atatttgaaa gagtatgatg 727081 aaattggatt acttgaagta agatcgaagg aactaacaat tcctaaaatt tcttcaattg 727141 atgatattct aaaaagtggc ttatctgcat tattaggtga taatttaaat aatgatataa 727201 ctaggtcaat ttttgataca agttcacttc aaaaggttac gacaatgcct gaatacgttg 727261 caaagcgtaa aaaaataaaa gattttggaa agtttgaaga gctattcaag aagtgccaca 727321 aggaaattac agagggtaaa cgaaaaattt taactttcaa aaatgaacaa gacatacagt 727381 caaatagttt ttatatatta aaaggagttc ttctttatgt tgaagatgtg ggagaacgta 727441 aaaaagcaaa gggaaaaacc aatgctagac ttcgatgtat atttgaaaat ggaacggaat 727501 cagatatgtt actacgttcc ttatcagcgg agttatataa acatggtaga cgtgtgaccg 727561 acaatgaaga tacattgttg gataatgtta gagaagatga tgtttcgact ggctttattt 727621 acgtactaaa atctttgagt acagatccgc aaattagttc cattaagaat ttatataaga 727681 tcggttttac aactggttca gtagaaaata gaatcaggaa tgcagaaaat caatcaactt 727741 atctttatgc tccagtagaa attgtaacca catatcaagt gttcaatatg aatgctagca 727801 aatttgagac ggcaatccat catgcgctag caaataataa tttggatgtt tctattttgg 727861 gggcaaatgg aaagatgtta gttcctaaag agtggttcgt tgtcacactt gaagatttac 727921 aagctgtaat agatgagatt gtgatgatgg ttcatcttta tgactaaatt agtatattag 727981 gattttagta ttaataataa ttttatagta gactatgaaa aaatttgatg ccataacaat 728041 aacttgttcc gctttggagt ttgtcacaat tgtagaatta tgtgttgcga gtattaatag 728101 gaaggggttg agcgaccgca aaaaaaattt tcggtgctgt ccgcaaaagg gagtttgggt 728161 gttttgcgtt atatttggtt gtgtgaaggt tagcggaaac tcaattcgtg aagttaggat 728221 tgcggttatt acgactgagt agtttcgtca tactctttta gcagtttttc tgtcttatgc 728281 atttctttga gcatcggatt catgtagtcg ttagctgatt ctagatatgc tctcgtcaga 728341 gtgtctagtt tatttctaac tttagagagg tcttcttcga attttccatc cgatgattga 728401 aggataaatt cttttgcctc ttcatatctt tttaatatgt ttttcaccat tggagttgga 728461 ttcttttgat ttattgtttt tattacagtg attgttaaat ttatttgttt tattaattct 728521 tttcttactg tcaaggtgat gctcctttta aatctctatt ctatttgaga gttgctatat 728581 ctgtttaatg gtttgataga ctactcatct ttataattta gagcaatttt tacaacttgt 728641 tccgctgtgt aatcttcatt gctccagaaa attaaatcac ttggtgccgg ataaggaaca 728701 tttttctcta ataaatcgag atattcactg actttctcat catctaatgt tgggttcatt 728761 aattccttta caagaaagat caactcttct tttgtcagtt tatccattgt ttgccctcca 728821 atagattgta tctccattga ttttacaaat gactttattt cttctgataa tgttataggt 728881 tgtttgcata atgatagata attgtcttga gaaaagttag tctcattata gagtttatta 728941 attgtattta taacaatata ttcatatgga aaacctctaa aatatcttta ttttagattg 729001 gtttataaaa aatagctcag cagagtaggg ctgagccatt ttttaattat agaccgaggt 729061 aactaattac aaattcttta tcatcctcat cttcaggcaa aataccaagg tttttatatt 729121 cccatattgc gattctttca tatccatcta attctgaggc taaaatatca tcataattat 729181 aatctaattg gaattctccg ctacgatcca atgttagtgt aaggttagtc caaacatcat 729241 cgttattatt tctgtgttca gttcttaatt cttcaaaaag ttctcttagt tctcttaaca 729301 acgtcttgaa aatatccttg cttacgttgt aatggctagg tatatcttgt gaataaataa 729361 tttgattatt ttctggtgtt ctgaaatgaa aaagaaccat tgtggaatca tctaatactt 729421 ctgcataaag atatatcttt gtccattcac caggtatgat gtcattgagt ttttctccaa 729481 taagttgata caaatcttgc atcttcctag tttccattct tctaaccccc aggctgattt 729541 ttaatagaga cgcttatttc ttttctgctc ccaattttgt aggttacatc gaaatatgat 729601 ggtctaagtg aatccccaga atagactggt tctatttgaa ctgctacttt tttaggtggt 729661 tttttgctta gggcttttgc ccactcctgc tccatctcat accatttccc accgctccta 729721 ttaatctgag aattcatcgg cacgatattg tcaaactggc ctgagccttt gaattgggtg 729781 gcgattaaat ggccgccgtc atcgtcaggc tttcggtcct ggggctttcc agcattcgtt 729841 tgtgcatatt ggtttcgttt cgcttctccc agctgcaagt ctgctttgac acttgtaatt 729901 ctaccatagt tgtcagtcgt gtacgtgtag ccttcttttg ttttgtagat gatattaggc 729961 ttcagcactt tctttctgct ccatcttgcg aaatgctcgc cgtatttgac ggttaccggc 730021 ggtacatgtg gcgctggagt tcgtcttccg cttgatgacg ttccgtatgg tttcggcagg 730081 atgaccttgg cgaatttttg cagtccttct ttaagcgtga ccccgttgac tgcgttgtaa 730141 ggaacgcctg ccggcactaa atcatgacgg ggatgatacg ggagaatatc cgcaagtgtg 730201 agatctccga tttgatttaa cttggttttg acgtgttttt ttgatacttc aatgcctgtg 730261 tttacttttt gtttgatgtg atcaacggtt tgttttgaga ctgttatggc tttttgggct 730321 gttgctgatt tgcttgctgc tgttttgact ttggtcgtca ctttggcggc tgtgccagtt 730381 tttgagacgg ctcctacgcc ttttgtgccg acaattgatg tgacaacagt gccaaccgca 730441 tatgacaccc atcttgctct tgagtaggtg tcaccattca ccatgtcttt ttgatacgat 730501 tcttcgattg ccgctgaaat ggcttcatac gttttgatcg ggtgagccat cgctccggta 730561 atcgcttcaa cggttcctcc cggatctgtg accatatccc acaggcctac gaccgcgtct 730621 ttcccggaat cataaaggcc gacggcaacc cctttgaagc ctgcttcaag ctcacgcgtg 730681 ttttcaattt gggtgaagta tctctgttgt tcagctgtca gattttcata gccgatcgtt 730741 tttgccattt cgtagaattc atcggcatct gcataatcgt agtttttcag tctttctttc 730801 agtttctcaa tctcgcgttc cttcgcttcc tctttcttaa tcttcaagta agcctcagtc 730861 cgcttttcaa tgtcgccttt tttcttatgt atgtcactct cacggtacgc cttggcgttg 730921 tagtggatgg gtgtggcgtt tttgccttta cccgttgctt cttggagctt ttggaagtcg 730981 gatttgatga attgttcgtt tggttcagac agggcgtatt ctgttttcag gtcttcgtcc 731041 aaggcgtcca atttttccag tgtttttttg cgtttgtcgt tggcatcggc cagctcgtct 731101 ttgaaggttt ctgttgaaaa caggtcgagc gggaggatgt cgtcgatatc gtttaggatg 731161 tctttcatcg cttttttctg ttcggacatg atggatttag attttttatt ggcatttgcc 731221 agttcgtgct ccaggaagga ttcttcgatg tatgcgtctg agaggccttt gtcttcggcg 731281 gctccggcga tgctgttgaa aaatgcgatt ttcatgtcga tgtagtcgat ccactggtcg 731341 gcgacgccga cgtggtcgtg atagaatgcc ttgatgttgc tggcgccttt tcctgagaat 731401 tcactgtcac tgagatcagc gactcctttt aacgcttttc tcaagttgac catttgcgtt 731461 cttagttctt tgtactcttt tgcacggtct gtcgcttccg aaagcagtgt tttcgcttca 731521 aatactttca tgaccatttc ccttcttttg ttcgctcaat atcaaaattt taccacgggt 731581 cgggataagg tgggggtgag aacgtgtttt ggtggaaaaa tgagtcattt ggcatgtgtc 731641 tttattcgtg gagggattgg aggaaacatg gtcgaaatga tattgattgc tacacatttt 731701 ttggaagttt gtattctata ttgtttttta aggagcatgt tgatgacgaa aaaacggatt 731761 acatttggtt tattagtttt aatggtatgt gtcatcctgt ttgttctgta tgttcagtta 731821 cgcaataaag atagtattcc tgtccaatct tccgccattc accccgaaga agaccgcatc 731881 ttttttattt actccaatcc tttcataaaa gaaagcgtgc tgctttcaac ctctacaggc 731941 gaacggttta acaggcgtac gtttaaggtg gcggatgtgc cttatattca aacgaaatct 732001 tatgcatcaa cagaccttgt attattggcg gaacacgagc ctttttacta cacgctggag 732061 aaggatgtga tcaaagagca tccgctgtca gatccatttg cgttttggta tgaggggaag 732121 gatgtcacta ttgaggccta taatgttgat acgacgggaa atgagatcca cataaacgac 732181 agaaaaacga aaaaggaata tacccttacc ttgcctccgc ttgtcacaat gggggccagt 732241 gatgagaact ttatttatat cattcaaagc atgtctattt acgtgattga cagaaaaaca 732301 gaggaaatga ttgagaccct gagcttagcc tcatacgctg atcaattcgc agactcggag 732361 gaatttatcg tcgcgagctc ggatcataaa ttgactgtga ttgaaaaagg gacatggaag 732421 acgacatata ttgcgtatcc tgaagatctt gaatatgcag atactgtgta ctatgacaaa 732481 gaaagcggca gtttttacgt ggcgtacgag gacaaagagg gtggagcgaa cttgctggaa 732541 tatggggagg atttttctat tcacacatac agcttgaaat tcccttatat ggaggcgaag 732601 tttaagggga atctattgta tatagttgcc caggaagagc ataaaaaggg catcggcgga 732661 tacgtgggtg tgtttgatat ccattctaag gagatgcttt atcagtttga tttgcctgag 732721 gaacaggtga aggttcagga ttttgttgtg gttgacaata agtgaatact atatgaaata 732781 gaatgacaaa gacccttgca taaagggttc ttttttatga aaaaaacaaa ttgacaggat 732841 gaaaaaacaa tttcttcctt ctatattgtt ttcaaaattt gggattgata gaatatgaca 732901 tatctcatag agaaggaggg aagccgttga gtcaagccat accgtcttcg cgtgttggtg 732961 ttaagattaa tgaatggtat aaaatgattc gccagttcag tgttccggat gctgagattc 733021 tgaaagcgga ggttgagcag gacattcagc agatggaaga agatcaggat ttactgatct 733081 attattctct gatgtgtttt cggcaccagc tgatgcttga ttatttggag ccgggaaaaa 733141 catacgggaa tcgccctaca gtgacagagc ttcttgaaac gatcgagacc cctcagaaaa 733201 aactcacagg tcttttgaaa tactactctt tgtttttccg cggcatgtat gaatttgacc 733261 aaaaagaata tgtggaagcg atcggatatt atcgcgaggc ggagaaagaa ctgccgtttg 733321 tgtcagatga tattgagaaa gcggaattcc attttaaagt ggcagaagcg tattatcaca 733381 tgaagcaaac ccatgtgtcg atgtatcata ttcttcaagc cttggacatt tatcaaaacc 733441 atcctctata cagcattaga acgatacaaa gcttgtttgt gatcgccggc aactatgatg 733501 atttcaaaca ttatgataaa gcgctcccgc atttagaggc ggcgctggaa ttggcaatgg 733561 acattcaaaa tgacaggttt atcgccattt ctctattgaa cattgcaaac agctatgaca 733621 gatcaggaga cgatcagatg gctgtagaac atttccaaaa agcggcgaaa gtaagcagag 733681 agaaagtgcc tgatctgctt ccgaaagtct tgtttggatt aagctggaca ttatgtaaag 733741 cgggccaaac acagaaggcg tttcagttca tagaggaagg attagaccat atcacagcac 733801 gttctcacaa attttataaa gaattgtttc tgttcttgca ggccgtgtac aaggagactg 733861 ttgatgaacg aaaaattcat gatcttttaa gctatttcga aaaaaagaac ctgcacgctt 733921 acattgaagc atgtgcccgg agtgctgccg ctgtttttga aagcagctgt cactttgaac 733981 aagcagctgc gttttatcgg aaagtgctga aagcccaaga agatattcta aaaggagagt 734041 gtttatatgc ctattaagaa aaaagtgatg atgtgtctgg ctgttactct agttttcgga 734101 agcatgtcgt ttccaaccct gacaaactcc ggtggattta aggaatcgac agatcgaaat 734161 acgacgtata tcgatcattc cccttacaaa cttagtgatc agaagaaagc ccttagctag 734221 ggctttttct tgctttacgg aagacgttcc attttccaca tcgcggcatt ccttctattt 734281 ctaacgcaag acactcgaaa caaccaaacc atttgaggta taatggataa agtgaataac 734341 agtatttaga ttgatatata tgaaagagag tggaacatca tgggccgtaa gtggaacaat 734401 attaaagaga agaaggcgtc taaggacgca aatacgagtc ggatttatgc gaagtttggc 734461 cgtgagattt atgtggcggc gaaacagggc gagcctgatc cggaatccaa ccaggcgctg 734521 aaggttgtgc ttgaacgtgc gaagacttac agcgtgccga aaaacatcat tgaacgtgcg 734581 atcgagaagg cgaagggcgg agcggaagag aattacgatg agcttcgtta tgagggcttc 734641 gggccgaacg gatcaatgat tatcgttgat gcgctgacga ataatgtaaa ccgtacggcg 734701 ccggaagtgc gtgcggcgtt cgggaaaaac ggcggaaaca tgggtgtgag cggatctgtt 734761 gcttacatgt ttgacgcgac ggctgtaatc ggtgtggaag gcaaaacggc tgacgaagcg 734821 cttgaaatcc tgatggaagc ggatgttgat gtacgtgaca ttttagaaga ggatgacagc 734881 gcgatcgtgt atgccgagcc tgatcaattc catgcggtgc aagaggcgtt taaaaacgcg 734941 ggtgtcgagg aatttacagt agcggagctg acaatgcttg cgcaaagtga agtaacgctt 735001 ccggatgatg caaaggaaca gtttgaaaaa ttgattgatg cattagaaga tttggaagat 735061 gttcagcagg tatatcataa cgttgattta ggtgagtaag gagtgagcag gctgttatgg 735121 cctgcttttt ttgtcccgga aattgtttta gctgtatgta ggcggccgcc tatacgatct 735181 ataagatatt ctcatactct ggactgtaac ctatgtgaag gagagagtaa atatgactga 735241 tacaagacat atgtatggcg gacctggttt tggtcattat cagggctttg gtattggcca 735301 cccgggctat ggcatgcaaa gcacaggcta tccgggctat ggcatgtatg gaggccaccc 735361 gggctatggc atgcaaggct acccagatca cggcatacat ggaggagtcg gcggctatcc 735421 gggatatggt gggtacggcg gttacccaag cggcggctat ggaggctctc cgggaactgg 735481 aagctatccg agcatgcacc atgaaaatga tggccatcac cactattatc accatcatca 735541 tgatggaaaa gataatcttc atcaccatca tcaccatgtt ggaaaggata atcatcacca 735601 ccatcatgat ggtcattatg gccaccatca tcaccatatg ggccactggg gaaaagacgg 735661 ttataaataa agaagatgat gataaaaaga ggacactctt gcagatcaag agtgtttttt 735721 tagctttttt cttgactgtt cagtctggaa aatggtaaca tttgtttcag gaggtgatca 735781 ttttttgggg aggaataaag aatttgatac ggcgcttgtt cttcacaggg cgatagaggt 735841 ttttggagag tatggctacg aaggaacgtc tcttcaggat ctgctctctc atttaggcat 735901 tgcgcgccaa agtttgtatg atacgtatgg aacgaagcgt gatttgtttt tgtccgctgt 735961 gaaatcgtat cttgaaggga aaaacgctgc cgttatggaa aggcttgaag cgccaggatc 736021 tgtaaaggaa gccattcgtg atatttttca ggagggtgtc aatgccctga gggatccgga 736081 acgggcgaag gcgtgctaca ttattaacag cgcgattgaa cagatcccgc atgaccctga 736141 gcttgcccgg tattttgaaa gacaatccaa gcagcttgag gacgcttttt atcacgggct 736201 tttaagagcg aaggatcaag gagaattgaa tggcgaagat actgatatat ctgcgcttgc 736261 tcggtacctg aatcagagca ggctgtcact gacatttatt gcaaaagtga cggcagatat 736321 ggatcggctt caggaccatg ttgacgtgag tttatcagtg cttgattaac atgtggtaaa 736381 ggattctttg cccatgtatg tactttttgg actgaatagt ctagaaataa aaatgaggtg 736441 atgatgaatg ttgatgaatg agtttgaaaa agcatgtgaa acattgagaa agtttatggc 736501 ttatatgctt gagaaggaca tgaagagctg gacggagctt tgggatgaga atgctgtatt 736561 tgagtttcct tatgcgccgg agggatcacc aaaaagaata gaaggaaaag cggccattta 736621 cgattatatt aaagattatc ctaagcagat tcatctttct tcatttaccg ctccgacagt 736681 gtaccgttca gcagactcga atacggtgat tgcggagttt caatgtgacg gccatgtgat 736741 tgagactgga ctgccttatc gccaaagcta tatcagtgtc atcgaaacga gagacggccg 736801 cattgtgcgt tatagggatt attggaatcc gcttgttgta aaagaggcct ttggaggatc 736861 atttttgcaa acagaggaga gtgggaaatg atgaaacaga atccgatttt aatcacgggc 736921 gggaccggca cagtcggcag ccgaatcgcc agccgtttaa taaagctggg atacagagtg 736981 cgtattgcaa gccggaaaaa gggcgcgctt gctgatgctg agtatgtgta ttttaattgg 737041 aagtacgcct ccagttttac gcctgctctg gaacaggtaa aacagatcta tcttgttgct 737101 ccggtcggtg tatttgatcc ggctccctat gtgcttccct ttttaaagga agcaaagcgt 737161 ctcggcgcaa agcgggtagt gatgcaaagt gcgtctgttg tctccgagaa cggtcccgtg 737221 tttggcgcgc ttcaccaggc agtgcgcgag tttccagaat ggacggtgct gcggccctca 737281 tactttatgc aaaatttcat caatgtccag caccgcatgt ctattcaaac ggaggggcgc 737341 atcacaacgg cttcgggtga aggaaaactt gggtttattg acgctgatga catcgcagaa 737401 acagccgtca gggctttgat tgatgatgtt cctcatcaaa cacatcatat tctgacaggt 737461 cccgaggcgc tgagctatgc cgaagcggcg gagatcattg gagctgcggc gggacgccgg 737521 gtggagcatg tcagcatttc tcgttccgag ctgcagcata aaatggaggc aggaggtttg 737581 cccgcggatt atgcccattt tatggcgaag cttgatgagg caattagcca tggtgcggaa 737641 catcgggtaa cggatacagt gaagcgtgtg acgggaaaag aacctcgttc gctgtcagag 737701 tttgcggctg ctcatgctgc atattggacc tcattttgga ctgaatagtc tagaaagacc 737761 ttcggcgctt ccgaaggtct tcttattgaa aaagctaagt cgtgttttag tcataatcat 737821 gcctcctgcc tcatacctat taaggtcatt gtttttgaga aaggaggagc cggaatgaag 737881 gatatgcagc cgtttacgcc tgtcaaatca tatacgccct ttcacagccg ttttgatccc 737941 tgtccgccca tagggaagaa atattacaga acgcccccta acctttatat gacctttcag 738001 cctgagcaca tggagcagtt ttcgccgatg gaggctttga ggaaaggcac cctttggaag 738061 gatctctatg atttttatga aaacccttat cgagggggag acgcacatgg caaaaaaggt 738121 tgacgccgaa tattatcgtc agctagagca aatacaggct gctgattttg tgcttgttga 738181 gctgagtctt tatttaaata cacatcctca tgatgaagat gcgttgaagc aattcaatca 738241 atattccggc tattcaaggc acttaaaaag acagttcgaa tcctcttacg gaccgcttct 738301 gcagttcggc aacagccccg cgggcaagga ttgggattgg ggaaaagggc catggccgtg 738361 gcaagtataa ggaggaatgc ctgaatgtgg gtgtatgaaa agaagctgca ataccctgtc 738421 aaggtcagta cgtgcaaccc gacgctggcg aagtatttga ttgagcagta tggcggagcg 738481 gacggcgagc tggccgcggc tctccggtat ttgaaccagc gttatacgat tcctgataag 738541 gtcatcggcc ttttaacaga tatcggcacg gaggagtttg cccatttgga aatgattgcg 738601 accatggtct ataagttaac gaaagacgcc acaccggagc agctgcgtga agctgggctt 738661 ggcgatcatt acgtcaatca cgacagcgcg cttttttatc ataatgcggc gggcgtgccg 738721 tttaccgcga gctatatcca agcgaagggc gatccgattg ccgatttata cgaagatatt 738781 gccgcagaag aaaaggcgcg ggcgacgtat caatggctga ttgatatttc ggatgatcct 738841 gatttaaacg attccctgcg ttttttgcgt gagcgtgaaa tcgtacactc tatgcgcttc 738901 agagaagcgg ttgaaatttt aaaagaagaa cgggataaaa agaagatttt ctaataggca 738961 gattggcctc tctttcatac acccttttac atacagagaa aatggtctgt ttttgcagtt 739021 tggtctgcat tataatcaag gtgtgtgtgc aagcttactt tttgattggg aggcctttat 739081 gacagctttt aagattgaga acgaaacgat tgcagatgga ttttacgcgt gtccggccgt 739141 ctatgaggat gcagaatcga ttaccgggtt gctcgtccga acagctgaat ggctccggga 739201 tcggggttct aaccaatgga gcggacttct caaagggcaa gatatacatg atatcacggg 739261 gtcaattgaa aagggacatg tgtttgtgtt taaaaaagat gaagagcttg cggctgtcgt 739321 gatgctgctg cctgcaccga gcgagtggga ccggacgctt tggggagacg atgggcatga 739381 ggagtccatt tatttacacc gcctcgcagt aagccgccgg tttgcgggac aggggcttgg 739441 agcccgcgtc cttcagtggg cggagacggg catacacttt ccggaaaaaa cgcggatccg 739501 gcttgactgt gtcgctgata gtgacgccct gcattccttt tatcggcgta tgggatatga 739561 attcatgggt gctgatgcgt ccggatatca tttgtttgag aaagagatta cggcagaata 739621 agcgtccttt gcagggggct tttttgtctt tttctaaaag ggaggcaggc gatgtgtggt 739681 caatattatt tgtgacaggg attgtgacgg cttgtctgtt tgctggcgta tccgtattga 739741 tgcggatgag atttcctgac aaaagtcggc cggaatggat gttggccggg ctgatcgtcc 739801 ttggtgtgtt tgcgatctgg tacagcctcg tgtatgtacg cggctgggaa ggggctgcgc 739861 tcggaatgct tggattcaat gtcattttcg gagccattgc cggatatttg atcgataagg 739921 ccatccggcg ttacaggaaa agataaggct gctgccgtct ctcaacaggt cgaaattttc 739981 acagaccggc aggaattttc tttcgaaagg agaaatacat attactttaa aatgaaagcg 740041 ttttccaaag caggaaggtg atgttgatga tacacagtgt ggcaaatggg ctgaatcatt 740101 tttgtacgtg ggtgatgaga ctggcctatt tgaatgtgct ttggattttg ttttctcttg 740161 caggcctggt tgtatttggg ctgatgcccg ctactgccgc gatgtttaca gtggcgagag 740221 aatgggcgaa ggggaataca gatgccccgg tgttttctgt cttttttcgg acgtttaaaa 740281 aggaatggcg ggcatcacag atcctcgggc ttatcgttgt gacggctgcc ctgtttctgt 740341 ttgcggatat gcggatagcg gctcagatgg accagcctgt gctcgtcaat gtattcgtga 740401 gcattagttt gattttcgcg tttgttgtgc tgtatgtgtt cccggtattt tctcattttg 740461 acgtaaaaat cagagaggtg ctgagcatca gctttttcat tgccttcagt cgtccggcgg 740521 tgacgctttt gatggcagcg ggcgctgtcg gtgtgctttg tctcgttctg tttcatgtca 740581 cgtttctatt gtttttcagc gggagtttac tcagcctgat cttaacgaag ctgtccttta 740641 aagcgtttcg gtcaatggat cagcggcagg agaaagaaaa ggcggcatga agaaaagagt 740701 tgctggctgg tacaggcgga tgaagattaa ggataagctg tttgtgtttc tatcgttgat 740761 tatggccgta tcctttctgt ttgtatacag cggggtccag tatgcctttc atgtgtatga 740821 tgagcagatt taccgcaagt cctcggaggt gcttcggatg tcttctgaaa ggatcgaaga 740881 cgagctgaag aagatagagg atgtgtcata tgaaatcatt acagacgaac agattcagcg 740941 catcctgagc atgcaaaatc gggatgatac gtatgatcaa tatcaaatga agcaggagct 741001 gtgggatcag cttgcgggat atgccagcga tgaaaagtac atcgattcca ttcatgtgat 741061 tgatgcccgc ggctcagagt attcagccgg aagcagttct tcagatcttt tgcagcagga 741121 gcaggaagag gtatttaagc gagcgaaagc gaaaagtgga agaaatcttt ggatgacgct 741181 cggcgggtca gaccccgtcc tgatttcagc acggcagatc aggtcctatc accagctgag 741241 tctgaacggc ttgggcatgg tactgatcca ggtcaatgta aaacagatga ttcgtgatgt 741301 gccgaaggat tggggcgatt cagtcggaga cattatgatt gctgaccaag gcggtaattt 741361 ggtgtatacg gcacatgcat cagcgcatgt tcctgaggca gcaaaagaga cgttgaagca 741421 ccccggttat gacttgataa aaaagaatgg caaacgttac tttatttctt atcttcaatc 741481 atcctaccaa aattggagct actataacgt tatccccttt gatcagatgt tcgcaaaaat 741541 ttcctttatg aaaacagtga tcggcacatg ctttcttctc tttttctgtg tggttttgct 741601 tttcggaagg aaaatcgcca acagcatcac ggagccgatt gaacagcttg tgaccgcgat 741661 gaaatcggta cagcacagcg gcattgaagc aggtgtgtcg ctttctctgc cggaacatac 741721 acaggatgag gccggcatgc tgaaccgcca ttttactgtc atgatgaaac ggattaatga 741781 gctgatggaa gaaaatgtgg aaaaacagct catcattaaa gaaaccgaat tgaaagcact 741841 gcaagcccag atcaatccgc attttttata taacacgctc gagtccatca attggctggc 741901 caaggcgaat cagcaaaagc aaatctcaaa aatggtggaa tcgctcggtt ttcttctgcg 741961 aaacagcata catatgaaga aggatatcgt gaccattcag gaggaggcgg acattgtacg 742021 tcactatatg accattcagc gatttcgatt tgaagagcgc ctgaaattca cgttggatat 742081 tgacgatgag gtgaagcatt gcctcattcc gaaactgacg ctccagccgc ttgcggaaaa 742141 tgcgattcaa tacgcgcttg aaccctttac aaggccatgc gccatccgga ttcaggcgaa 742201 aaaggcgaag ggctgtgtct gtattacggt cgaagataac ggccctggca tggatggacg 742261 gattcttgaa tcaacgggtg gaagaggaat cggactttgg aatattcgcg agcgcatcag 742321 cctgacattc ggagagccat acggattgcg gattcatagt gagcatgaaa aggggacgag 742381 gattgtgatc acaataccgt gccgaaatga ggtggtgtga tgtataaaat actgctggct 742441 gatgatgaga ggattatcct tgatggaatg gcgggaatca ttgagtggga gtcgcttggc 742501 gcctcattga tcggaaaagc gcagaacgga catgaagcat atgaaaagat tgtacataag 742561 cagccgcata tcgtcatcac agacgtcaaa atgcccggca tggacgggct tgagctgatc 742621 aaaaaggtgt cagccgtcag cccgtcggtg caatttatcg tcctgtccgg gtttggagag 742681 tttgagtacg caaaggaagc catgaaatat ggggtgaagc attatttgct gaaaccctgc 742741 aatgaacagc agattatcag ctcgctggag gaaatcattg ctgagctgaa gcggcaagat 742801 gtgcacaaaa agaaaacagc ccatctgaaa cacgagctgg accatatccg ttcctttgca 742861 gccgatcaat acttggaagg cttgatcgcc ggtgtggccc agctttctcc gccgccttca 742921 cttgccggaa aaaagatccg cctcttgatc ttaaaagggg aacaatctat tgatgctgca 742981 gccagagagg cactcggatc ggcactgaca gcggtttgca gcagcggtga atggaccgtg 743041 ctcgccgtag aggagaacgc cgctgaaaag gtggcggagg tttttgcgga ccgcaagatg 743101 gccatcagtc aggcgggaga actccggcac gcggggcagc tgtttcgtga cacagctgaa 743161 gcgtctggtg acctgcatgg gagcgcagtg atttcaaaaa tgatcaggct tattgccgac 743221 gagctcggaa atccgaatct gtccttaaaa tgggcggcga aggatatgct gtttatgaat 743281 cctgattatc tcgggaagtt atttaagcag gaaacaggcg agaaattttc ccaatatgtt 743341 acacgggtgc gtcttgagca tgcgatgaag cagatgaaaa taaggaggga cgtgagcgtt 743401 tcagaaattg ctgaagaaat cgggtttggc gataatccga agtatttcag tcttgttttt 743461 aaaaaatata ccggtctgac accgtcagaa ttcagaagaa aacagggagg cgcttccgca 743521 ggatagccat ctctgttttt ttgactttcg ccactgtttt ttgagtgttt cgccctatcc 743581 gaacgcttta aaataaaatg taagcactta cattaaaggg gggattggtt tgaagaagat 743641 ttgttacgtg ctgttatccc ttgtctgcgt ctttttgttc agcggatgtt cagcgggtga 743701 agaggcctcg ggaaaaaaag aagatgttac actcagaatc gcgtggtggg gcgggcagcc 743761 aaggcatgat tatacaacta aggtaattga actatacgag aaaaagaatc cgcacgtcca 743821 tattgaagcg gaatttgcga actgggatga ctactggaaa aagcttgcgc ccatgtctgc 743881 cgccggccag cttcctgatg tcattcaaat ggataccgct tacttagccc aatacggaaa 743941 gaagaaccag ctggaagatt taacgccgta tacaaaggat ggaacgattg acgtcagttc 744001 aatcgacgag aatatgctgt cgggcggaaa aatcgacaat aagctttatg gatttacgct 744061 aggtgtcaac gtgctgtctg tgattgccaa tgaagatttg ctgaaaaaag ccggtgtgtc 744121 tatcaatcag gaaaactgga cgtgggagga ttacgagaag ctggcgtatg atcttcagga 744181 aaaagccggt gtctacggtt ccaacggaat gcatccgcct gatattttct tcccttatta 744241 tttgcgcaca aagggtgagc gcttttataa agaagacggc actggcctcg cgtatcaaga 744301 tgatcagctg tttgtcgatt actttgaacg gcagctgagg ctagtgaaag cgaaaacgtc 744361 cccaacacct gatgaaagcg cacagattaa agggatggaa gacgatttta tcgtcaaagg 744421 caaatcagcg attacatgga actactccaa tcaatatttg ggctttgccc ggctgacaga 744481 ctcgccgctg tctctctatc tgccgccgga gcaaatgcag gaaaaggcgc tgacactgaa 744541 gcccagtatg ctgttttcca ttccgaaaag ctctgagcat aaaaaagagg cagcgaaatt 744601 tattaatttc ttcgtgaata atgaggaagc gaaccagctg attaaaggcg agcgaggcgt 744661 tccagtctcc gacaaggtgg cggatgcgat taaaccgaag ctgaatgagg aagaaaccaa 744721 catcgtggag tatgtagaaa ccgcgtcaaa aaacatcagc aaagccgatc cgccagagcc 744781 tgtgggaagc gcggaggtca tcaagctgct gaaagatacg tcagatcaga ttctgtatca 744841 gaaggtatcg ccggaaaaag ccgccaaaac gttccggaaa aaggccaatg agatattaga 744901 gaggaataat tgacgggaaa tggggctgac gcaatgaaaa aaagccggag tataagaaaa 744961 gacaatctgg cgggatatgc ttttatttct ccgtttatca tcgggttcct atgctttacg 745021 gtgattccga tgggggcgtc cctgtttctg tccttcacga gctatgactt gtttacggcg 745081 ccgaaatgga tcgggctcga caactttaag gaaatgttta cgggtgacga aaagtattgg 745141 cagtctctga aggtgacgtt tacgtatgtg cttgccgggg ttccgctccg cctcggcttc 745201 gcgcttttta tcgctgtcat tttaaacaat gcagcaaaag gaacggccat ttacagaacg 745261 ctcttttatc tgccttcgat catcggcggg agcgtcgccg tggcgattat gtggcgcaat 745321 atttttggca atgacggggt catcaatgcg ctgctgtttt ttgtcgggat tgatcaaaaa 745381 attctttggt accagaatcc gacaagtgcg ctgtggacat tgattctgct gtccgtctgg 745441 cagttcgggt cgtcaatgct gatttttttg gccgggctga aaaacattcc gtcttcgtat 745501 ttggaagcgg caagtgtgga tggggcaaat cgggtgcagc gtttcttcaa gatcacgctt 745561 ccgatcctta caccgattat tttctttaac ctagtgatgc agacgatttc tgcttttatg 745621 acatttacac ctgcctatat catttcgaag ggcgagggcg ggccgcttga cgggacactt 745681 ctctattcgc tctatttgtt ccagcgtgcg tttaactatt ttcaaatggg ctacgcatcg 745741 gcgatggcgt gggtcatgct tgtcattgtc gggctgatta cgctcatatt gtttaaaaca 745801 tcgtcatatt gggttcatta cgagtcaaag gaggaatgac ggatggagcc ggtcaaccag 745861 cctgtcagag aagccccggt ttttgagaga aaaaaagccg ggcgcgtcag tcccaaacgc 745921 atactgttcc atgtttttac ggcaacgctg gcggtgttgc tgctgtaccc ggttatttgg 745981 ctgtttgtca gctcgtttaa agaaagcgcc agtattttta caacctcaca ttctctcatt 746041 ccagaccctt ttattctcag taactatgct gaagggtgga agggcattgc gggacagccg 746101 tttctgacgt ttattaaaaa ctcggcgatt attgtcgggc tgtcaacaat cggtgccgtc 746161 atgtcatcgg ctgtcattgc gtacggattt gcgcgtatac cgtttaaggg aaaaaaattt 746221 tggtttgcgt gcatgatggg gacgttaatg ctgcctcatg aagtgttgat gattccgcag 746281 tatattatgt ttgcgaaatt agactggctg aattccttta aaccaattgt cgttccgcaa 746341 tttttcgggc atgcgttttt tatctttctg atgatccagt ttatccggac gattcccgag 746401 gagctggatg aagccgcgcg aatcgacgga tgcggacgct ttgcctgctt ttggcggatc 746461 attctcccgc tgattgcccc cgcgcttgcg acgtctgcga ttttctcctt ctattggaag 746521 tgggaggagc tgattcagcc gctcttgtat ttgaataagc cggagcttta ccctgtttca 746581 cttgcgctga agctttttct cgatacagag tcggcttcga actggggcgc gatgtttgcc 746641 atgtcagccg tctcgttatt gcctgtgatt cttgttttct ttttgtttca gaaatatatc 746701 gttcagggca tcagtacgac cggattaaaa taaaaaggag tgttgcagat ggcacagctt 746761 atctttgatg aagaaaaggt gacgtcggtt attgaccgga tcgtgaaacg gacatttcag 746821 atggattttg cgtgggattg gccgggcggc gttgcgtttt acggtgtggc ggaggcctat 746881 gaagcgacgg aaaacgagga atatatcaat ctgttaaaaa cgtgggtgga tgaacagctg 746941 gaggatgggc tgccgccgct ttcgatcaac ggagtttcca ttgggcatac gcttttgttc 747001 ctccacaagg tgacaggtga tgacgtgtat ttggaaacag cggccgagat ggcggaatat 747061 gtgctgcata aggcgccgcg ctttggcgag ggtatccttc agcatacggt gaatgcggca 747121 gaatacgtat tccctgaaca ggcatgggcg gatacgctga tgatggctgg gctgtttatg 747181 ctgagaatcg ggcgggtcat ggagcgtgag gattattttg aagacggcct gcgccagttt 747241 cacggacatg aggatgtgct tcaggaccct gtcacgaatt tgtactacca cgcctgggac 747301 aacaaagcgc aaaatcatct gtcggggatt tattggggca gggcgaacgg ctgggcggca 747361 ctcacgatgg caaaggcgct cccgcttatt gaggtgacac atccttcctt tatgatcatc 747421 gacggatcgc tcagagacca gctgagcgcg cttgtccggc ttcaggatga atcagggctg 747481 tggcatacaa ttttggatga tccggattct tatctggagg tttcggcatc agcgggtatt 747541 gcttctgctc tgatgtcgag cggaaagctg tatacaaaat atgtgcagaa atcgcttgcc 747601 gccattttgg atgcagtgga agaggacgga cgggtcagca gggtatcggc cgggacagcc 747661 gtcatgaaaa atgccgaagg atacaaacag gtgccttaca aacgaataca aggatggggg 747721 cagggacttg cgctgacgtt tcttgctgat gttttgaaaa cgaaaaaacg cttgtatcag 747781 taaagatagc ggcgggggga gagggatgaa aaaacagcct caacagaagg aacgggtttc 747841 tcgctggaag ggaacgtatt tcaaaagaaa ctttgtcttc attttgctga ttgcctgtat 747901 tcccggattg ctgactggcg gcgcaatcta ctttctttcg atcgacaagg tggagaaaga 747961 gctgcagaga tcgcatgaaa cacaggtggc gcgtgaggtc agccgaatgg atgagaagct 748021 gggagtgctt gaactggcac tcacccagat ggcctacgat tcttcactga tgaacggatt 748081 ggccgagagg gatttggaga aagactttac gttctcctat caattaacga aaaagctgtt 748141 tcttttgcgg gatcagcagc cgctgatcga gcaggcttcc atctttctga acagcccccg 748201 gccacttgtg ctgagccctg aatacagcgc tttgacagaa caggaggcgc ttcgcaagta 748261 tcgctcgctg cttgcctcag accacagcat ttattggaaa cggtcgggaa accaagcgat 748321 gctgatccag ctcattccgg gcgcggcgga gaaaccgttc ggcgcgatca tgctggcggt 748381 tgatccgaaa gaaatggaat caatcctgca aagcttgtcc ccctatcctg atggcagtgc 748441 gttgctttta gatcaaaatc gagaggtgct gtttcatgag ggggaaaaag attttgaaaa 748501 gactttactt catgagataa aaaaacagcc tgctgagaac ggccattttc agatggaatg 748561 gaaaggcaag gtgtattctg tctcctttgg agaaatgaac cggatgcatc agcaatggac 748621 ctttgtgtca gcggcgcctc tttcagctat tacagcgccg atggtgtttt tatcaaaagt 748681 gatcatcgtg atgctggtca tttgcatcgg tttggcggtg tgcatgacat ggtatgcatc 748741 aaaaaaaatc tatcgtccca tccagcattt gcttggcttg tttaccggag gagagaagaa 748801 aacatggcag gcgtccgggc aggatgaatt caaatggatt gaaaagagat ggcaggatct 748861 atcccttgaa agccggaagc tccaacagca gctcctgcgg cagacgcccc atatgaaaaa 748921 gagttttttg cagcatctct tacagagcga tttttactat gacaacgagg aaagcctcag 748981 atttcggatg gaggaggctg gctggaacat cggcggaaac gtgtttcatg tgcttgatct 749041 acaggtgaca gggctccgct gtgaaaaaag catcttccgt gaaggtgatg aacagcttgc 749101 cgtgtttaca ctgactaata tcgctgagga attggcggct aaacgcgttt ttcagctctc 749161 catacttgat atcggccggc tttctgtcac cgttcttgtg atgaaaacaa acagctctga 749221 tctgaaggcg tatataacgg agctggcacg ccaatttgga gatgtaaccg gactatgcct 749281 gacctcgaca ttgagcagca agacggagcg tgtcacggaa attccttctt tatttcagga 749341 tgtgaaatgc ggcaaatccc gcaggaagtt tgctaaccgg gatcaggtca ttgatttgca 749401 ggccgacttc cctcgggatg agcagttcgc tccttattac ccttttgagc tggaaaaaca 749461 aattgttcag accatccggc tggaaagaaa acaggaagcc aaggaactga tagatggatg 749521 tatgaaggaa ctgtcggaaa aagcggccat agacaggcat gtgcattccg ccctgattca 749581 gctgttttcc cgcattcagg aggatatttt gcattccggg ctcaatccca gcgaactgtt 749641 tcagcaccgg aatccgtttc ttgatatttc agaattgcgc gaacctaacg aagcggcggc 749701 ctggctgatg gatgtagtgg tgacgcctta cctttccaag cttgagggca gaaaaaacag 749761 acagcaaaag cagctggcag aacgtgtgat tgcgatgatt cacgaacagt atatggcgga 749821 catttcattg gaaagctgtg ccgatgcgct tggcatgaat tcctatacgt taagcaaggc 749881 atttaagcaa gtgaccggca ttaattttat cgattatgtg acccagatca gaatcgaaaa 749941 ggcgaaagaa ctgctggtca atacgaataa aaaaattcat gatgtgtctg aagaagtcgg 750001 ctatcgccac aattatttca atcggatttt taaaaaacag gtcggcatgc cgccgggtgt 750061 cttcaggcaa atgtatcagg aaacgccgtg aaaggagaga acatgtgatg aagaaaccga 750121 ttcaagtatt tttagcgggg gattccactg tgagtgactg cccgcctcat gaagcgccga 750181 tggcggggtg ggggcaggta ttcgggcaat tgttttctga aggtgtgctg gtccgcaatc 750241 atgccaaagg aggagcgagc accaattctt ttgtggagga aggaaggctt caagcaattg 750301 ccgagcacat cacacaaggc gattatttgt tgattcaatt cggccacaat gaccaaaaac 750361 cgcgggggac gaagccgtac tccacatttc agcagtttct taccttgttt gcagatacgg 750421 cacgcgaaaa gggcgcgcat cctgtgttcg tcacatcggt gcagcgccgc cgctttgatg 750481 aaaacggacg gatcgagcat acgctcggtg agtatcccga tgcgatgaaa gcactggcga 750541 aggagctcga tgtacctgtg attgatctgc ttgcgaaaac aaaggtgctg tatgaagcat 750601 acgggccgga ggagtcgaag cgattgttcg tttggtttca gccgaatgaa catccgaatt 750661 acccggacgg cattgaggac aatacgcatt tttcggaaaa aggtgcaatg gaggttgcga 750721 agcttgtggc agaaggcatt gaagagctcg gacttccgct taaggaccac cttgtgagcc 750781 gggagggaaa agaacatgta taaggaaggc gcttgcttgt accgcaatcc gctccggtct 750841 aaaagcgatg tgaaggattg gcggatggag ggaggcggac agatctcatt tgacgatcac 750901 agcttgcacc tgtcacatgt ccaggatgaa gcgcactttg tcttttggtg tccggaaacc 750961 tttccagacg gcatcattgt gacatgggac ttctctccga tcgagcagcc tggactgtgt 751021 atgctgtttt ttgccgctgc gggtattcgc ggcgaggatt tgtttgaccc aagtctcagg 751081 aaaagaacag gaacataccc tgagtatcat tcaggagata tcaatgccct ccacctgtcg 751141 tatttccgca gaaaatacgc ggaggaaaga gcgttccgca cctgcaattt aagaaaaagc 751201 cgcggtttcc atctcgccgc aatgggggcc gatccgctgc cttctccaga cgacgctgat 751261 tctccgtatc gtatgaagct gatcaaagac aaaggctatg tgcacttttc aatcaatggt 751321 ctgcccattc ttgagtggat ggacgacggc agcacatatg ggcctgtgtt aacaaaagga 751381 aaaatcgggt tccggcagat ggcccccatg aaagccgttt acagggattt tgccgtgcat 751441 caagcggtga gaagatgaag acgactgtaa cggatgcgct ttatgcaggc tgcgaagcgg 751501 tggtgaaaat agcatggctc aacgggctgt ggctgttgtt tacacttttg ggcggcgttc 751561 ttttcggatg ggcgccgagc acagctgcga tgtgtgccgt tataaggaaa tggctgatgg 751621 ggcaaaagga tgtcccgata ttttcgttat ttctcgatac ctataaaaaa gagtttctca 751681 aggttaatgc gatcggattg gcgttttcgg ctcttttgct catattgtct gccaactatc 751741 attatttttc tgccagtacg aattggctgt cctttgccgt aacaagctgc acgctgcttg 751801 cagggctttt gtatatcatc gcgctgatgt atgtgtttcc cctttatgtg cattaccagc 751861 tcccgcttcg caaatatatt ccgcaggcac tgctgtttgg cgccatgaga ccgctgacaa 751921 ctggctgtat gctgatcggg tgcggatttg tcctttattt gctgtatacg cttcctggcc 751981 tgatcccatt ttacggcccg tgtttatttg ggcttgtgtt gatgtttttt gctcttaggg 752041 gatttcaaaa gacggaggcc cagcaccatc aagccgggta acaaaaaaat gacaaataag 752101 caaaaaagtg cagtgtccga aataggcaga tgcaaaaaag tgaaattgaa gacagctcac 752161 aaagcgcata aaatccaatt taagtaagcg cttacagata aatgagaagg agctgtctga 752221 tgattagacg aaggaaacgc atgtttaccg ctgttacgtt gctggtcttg ttggtgatgg 752281 gaacctctgt atgtcctgtg aaagctgaag gggcagcgcg gcagatggaa gcgctgaacc 752341 gggggcttgt agcggtcaag acggacgggg gcatttttgt cagctggcgg tttcttggaa 752401 ccgaaaacgc atctgttttg ttcaatgtgt acagagacgg gcaaaaactg aatgctgcgc 752461 ctgtcaaaac aacgaactat gtggataaaa acggttcggc gggctcaacg tatacggttc 752521 gggctgttgt aaacggtacc gaacagccgg cttctgaaaa agcctccgta tgggcgcagc 752581 cgtatcattc cgtcccgctg gataaaccgg ctggcggcac gacgccaaag ggtgaatctt 752641 acacgtacag cgctaatgac gcaagtgttg gcgatgtgga tggtgacggg caatacgagc 752701 tgatcctgaa atgggacccg tccaactcaa aagacaattc acaggatggc tatacgggtg 752761 acgtgctgat tgacgcgtat aaactggacg gcacaaagtt atggcggatc aatctcggca 752821 aaaacatcag agcgggcgcg cactacaccc agtttatggt gtatgacctt gatggtgacg 752881 gaaaagcaga agtggcaatg aaaacggcag acgggacaaa agacggcacg ggcaaagtaa 752941 ttggaaatgc caatgcagat tacagaaatg aacaggggcg tgtgctttca ggccctgaat 753001 atctcactgt gtttcaaggt tcaaccggga aagagcttgt caccgcaaat tttgaaccgg 753061 cgcgcggcaa tgtgtcggat tggggagaca gctacggcaa ccgtgttgac cgttttctcg 753121 ccggcattgc ctaccttgat ggacagcggc cgagcctgat catgaccaga gggtattacg 753181 ctaaaaccat gctagttgcc tataacttca gggacggaaa gctgtcaaag ctttggacgc 753241 tggactcctc aaagtcagga aatgaagcgt ttgccggaca ggggaatcac aacctgagca 753301 tcgcggacgt tgacggggat ggaaaagatg agattatttt cggctcaatg gctgttgatc 753361 atgacgggaa aggcatgtac tcgaccggct taggccatgg ggatgccctc catacaggag 753421 atcttgatcc gggccggccg gggcttgagg tgtttcaagt tcatgaggac aaaaatgcaa 753481 aatacggctt atctttccgg gatgctgcaa ctggaaaaat cctttggggc gtttatgccg 753541 gcaaggatgt aggccgggga atggctgctg atattgaccc gcgttatccg ggacaggagg 753601 tgtgggcaaa cggttctctc tactcagcga aaggggtcaa aatcggaagc ggggttccgt 753661 cctcgaccaa cttcggcatc tggtgggacg gcgatctgct ccgggaacag ctggacagca 753721 accgaattga taagtgggat tatcaaaacg gcgtatcgaa aaatatgctg actgcatcag 753781 gcgcagcggc taacaacggc acaaaagcaa caccaacgct tcaggctgat ctgctcggtg 753841 actggcgcga ggaagtggtg tggagaacgg aggacagcag tgctctgcgc atttacacga 753901 cgaccattcc gactgagcac aggctgtata cgctgatgca cgatccggtg taccggcttg 753961 gcatcgcctg gcaaaatatc gcctataacc agccgccgca cacaagcttc tttttaggag 754021 acggcatggc ggaacagcca aaaccaaata tgtatacgcc ttaactgaaa gggggaagga 754081 acgggctgcg cgcagcccgt tcccatcaaa tgaaaccaaa aaagaggcaa atggaatacc 754141 tgaccagagg tttgattgcg gtacagacag aacagggcgt gtttgtcagc tggcgttttc 754201 tcggcacgga tcatgagacg acggcttttc acctttatcg ggatggaaag cggatcaccc 754261 gcgatccaat cgctgaaagc actaattttc tcgatcaaaa cggaacggct gactctgttt 754321 atcaagtggc ggctgtcaat aaaggacggg aagaaaagct ttccaagaaa gctcgtgttt 754381 ggcaggaaaa tgtcctggag gttcctcttg ccaaaccgga aggcggtgtg acgccggacg 754441 gaaagccgta cacttacagc gccaatgatg ccagtgtcgg ggatatagac ggggatggag 754501 aatatgaaat gatcctgaag tgggacccgt ccaattcaaa agacaacgct catgacggtt 754561 ataccgggga ggtgctcata gatgcctata aactggacgg cacctttttg tggcgcatca 754621 acctcggcag aaacatcaga gcgggtgctc attacacgca atttatggtg tatgaccttg 754681 acggtgacgg aaaagcagaa atcgccatga aaacagctga cggcacaaca gacgggaaag 754741 gacatatcat cggtgatgag caggccgatt ttagaaacga acagggcaga attttgtccg 754801 gtccggaata tttgaccgtg tttaaaggag aaaccggtga ggcgctcacg accgtggaat 754861 atgaaccgcc ccgcggcaag ctggaggatt ggggagacgg ctatggaaac cggatggacc 754921 gttttctcgc cgggaccgct tatttggatg gggagcggcc gagccttgtt atggcgcgcg 754981 gctactatac gagaaccgtg ctcgtggcat acgatttcag aaacggaagg ctcaaaaaac 755041 gatgggtatt tgactccaac cagccgggac atgaagcata cgcaggacag gggaaccaca 755101 gcttgagcgt ggcggacgtc gacggagacg gaaaggatga aatcatatac ggcgcaatgg 755161 ctgtcgatca tgacggaacc ggcctgtact caacgggcct cgggcacgga gacgcgatgc 755221 atgtagggga tctggacccg tcacgaaaag ggcttgaagt gttccaggtg catgaggacg 755281 ccacgaagcc gtacggactg tcgctgcgag atgccggaac cggtgagata ttatggggcg 755341 tccatgctgg aactgacgtt ggccggggca tggcggctca tattgatcca agctacaaag 755401 gatcgctcgt ctggggaatt gatccgccgg gcaatgatgg catgtcgtac gggcttttca 755461 cgagcaaagg cgaaaaaatc agcgacaaag cgccctcttc agccaatttc gccatctggt 755521 gggacggtga tttggtcaga gaactgcttg atcatgactg ggacggaacg atcggcaggc 755581 caaagattga aaaatgggat gctgaaaacg gctgtctgaa gacgatattt cagccggccg 755641 gcgtgttgtc caacaacggc acgaaaggaa acccggttct tcaggccaac ctgttcggag 755701 actggcggga agaagtgata tggagaacgg aagacagcag cgcgctccgt atctatacaa 755761 caacacatct cacccgccac tgcttttaca cgctgatgca tgatccggtt tacaggctcg 755821 gcatcgcctg gcagaatacc gcctacaacc agccgccgca cacgagcttt tacctcggaa 755881 cgggaatgaa aaaaccgccg aagcccgccc tgtacatagc gggaagcaaa gcggaggcgc 755941 cgctgtagga ggactaaggg ataagacgca aaggctgaac gctacgccaa gatgattaga 756001 gaactggcag gacgaaccaa tgctcaagcg ctgtacgcac cggttttttc aagggaagag 756061 ctatccgtga tggaagctgt ataaaaaacg aggaggaatg aaaaaatggc aaatcatatt 756121 tatcttgccg gcgattcgac tgttcaaacg tatggagaca gcacaaatca agggggctgg 756181 gggcagtttc tcggctcgca tctgccggag catattcaag tgatcaacag agcgatcggg 756241 ggaagaagct cgaaaacatt tgtggaagag ggcaggcttc aggcaatcct cgatgtgatt 756301 gagccggatg attggctgtt cgtgcagatg ggccataatg acgcgtcaaa aaataagccg 756361 gagcgctaca ccgagcccta tactacttat aaacaatatt taaagcagta tatcgcaggc 756421 gcgcgggaaa aaggcgccca tccgcttctc attacccccg tagcccgctt tcattacgaa 756481 aacggcgtgt ttttgaacga ttttcctgat tactgcattg ccatgaagca gacggccgct 756541 gaggagaatg tccagctcat tgatctgatg gagaaaagtc tcgctttctt tactgagaag 756601 ggcgaggaaa aagtgtacac ctattttatg atttcagaag ggattaacga ttacacgcat 756661 tttacaaaaa aaggcgcaaa tgaaatggcg aaacttgtgg caaaaggcat aaaggagctc 756721 ggcctgccat tgacagaatc gatcatcaaa gaaaggtgaa aatgtgatga gaaaactgta 756781 tcatggcgct tgctattatc cggaattatg ggatgaagag acgattcagc aggacattga 756841 catcatgcgt gaagttggcg taaatgttgt gcggatcggc gaatttgcct ggtcagtcat 756901 ggaacctgaa gaaggaaaaa ttgacgtcgg ttttttcaaa gaaatcatcg cccggctgta 756961 tgatagcggg atcgaaacga ttatgtgcac gccgacgcct accccgccga tttggttctc 757021 acatggccgg cccgaacgca tgcatgccaa tgaaaaaaga gagatcatgg ggcatggctc 757081 ccgtcagcat gcctgtacga acaacccgta tttccgaaaa aaagccgcca tcatcaccac 757141 agccatcgcc aaggagcttg gccggctccc ggggctgatc ggatggcagc tagacaatga 757201 gtttaaatgc catgttgcag aatgcatgtg tgagacatgc ttgcgcctat ggcatgactg 757261 gctcaaaaat cgctacgggg taattgagcg cttgaatgaa gcttggggaa ccgatgtgtg 757321 gagcgagacc tatcagacgt ttgagcaagt cccgcagccg ggaccggccc cgtttctgca 757381 tcatgcctct ctacgcacta tgtatcagct gttttcgatg gagatgatcg cttcgtttgc 757441 ggatgaacag gccaaaatca tccgctgcta ttcagatgcg ccgatcacgc ataacggatc 757501 agtcatgttc agcgtggaca atgagcgaat gtttcagaat ctcgattttg cctcctatga 757561 cacgtacgct tcgcaggaaa acgcctctgc ctttttattg aactgtgatt tatggagaaa 757621 tctgaaacaa gggcgcccgt tttggatttt ggaaacgagt ccgtcgtatg ccgcctcgct 757681 tgaaagctcc gcttacccgc acgcagacgg gtatttgcag gccgaagccg tatcgtccta 757741 cgccttaggg agccaggggt tttgctactg gctatggcga cagcagcgtt caggcagcga 757801 gatttcccac ggttcggttc tcagtgcctg gggcgaaccc accatcggct atcaaaatgt 757861 gctggcggtt gagcgggcaa gaaaggaaat cgagcctatt attctatcga ctgaacccgt 757921 tcaagccgag gcggcgatga cttactctga cagagcaaaa gcatttatta aaactgagcc 757981 tcaccgggga ctccggcatc gttcgcttgt gacgcatttt tatgaacgta ttctcaacac 758041 ggggattcac cgtgacctta ttccggaagg cgctccactg gacggctatc gcttgctgtt 758101 tacgccattt gtgccgtatt tgtcttctga atttatcaaa aaagcttcgg cattcgctga 758161 agcgggcggc atctggatca ccgggccgct gacaggagga cgcacatgcg agcataccat 758221 tcataccgat tgcggacttg gcgaacttga gaaaacgtca gggatcaaaa cactttttac 758281 ctttccgatg aatgagaacg tgaatacagg aaaagcgttt ggcatcacgg cgccgctcgg 758341 actgtggagc gcggtgtttg acacagagag cggaaacacc cttggcacgg ttgaagcagg 758401 accgggggcg ggccatgctt ttctgacgga acggaattac ggcgagggga aaattgtcat 758461 gctgggctcg cttccatccg ggaaagaagg ggatgcgatg ctggaagcgc tcgtcaggca 758521 ttatgcggag gaagctgtta tttccagccg gtcggatgtg acacccggca cgatcgttgc 758581 cccgcgtata ggcgaaaacg gccttgtgtg gatcgttgtg aatatggatg gaaaaggcgg 758641 gagcgtgaca ttgccggaat cgggaacgga tttgttgacg caccgcttgg aaaaggcggg 758701 gagactggcg gtcggaccgc atgaataccg tgtgattcaa tttgacaatc acagctgatt 758761 ctttgtatcg aatcagcttt tttctatgga gggagagaca gatgaaaaag atcaaatggt 758821 tatcaggaca gccaaaggtg acaagcggcg tgacgtgggg catgccatgg aaaaaaggag 758881 aattaaaaaa aggagaccgt ctggcgctta tgaatgaaaa cgcggaaacg cgatatgtgc 758941 aaagcgaacc gtcggcctat tggccggacg ggagcatcaa gtggacgaag cacgcggcgg 759001 tgtttggcgg tcaggaaaac caaagcttta cagtgcacaa aagagaagtg ccgcagccaa 759061 ctgaatcgct cagcattctt gagacagagc atgatatcca agtggataca ggagcactcg 759121 tttgtaccat tcataaaaca ggatctgatt tcattcaatc attgcagatc aatggaaagc 759181 cgatcgccgc aggcgggagg ctcgttgcga taagagaaac gagaaaagag tcagcggcga 759241 aaatggttct tttgcatgaa aggtctgtca gctttatcaa acgggcggcg attgagcaga 759301 gtggtcctgt caaagcagta gtcaaaatcg agggagtgca tgtgcttcat aaaacgtatg 759361 aggaatggct gccgtttgtc atccgattaa cgttttatgc cgggctgtct gagatcggcc 759421 ttgtgcacac gcagctgatt gacaggagcg gtaaactaga attcgttaag gggctcggca 759481 tcgaattcga cctttttttg gagggagagc cgtacaaccg ccatttccgc tttgcgggag 759541 agaaagggat gtataaagaa cccgcccagc tgtttggcac acgtaaattc aatgaacgat 759601 atccgcttta tgaaaaacaa atcaatggcg aaatgctgtc tccagatgaa gagcataagg 759661 aatggtttgc acatggcaca cagaatgcgg tttgggacga tgtcaagatc gtgcaagatt 759721 ccagcgatca ttacagcctg tcaaaacgga ccggaaaaga ttatgcgtgg gttggaatgc 759781 tgcatggcag ccgggcgaag gggctctgct atgcgggcgg aaaaaatggc ggtgtggctc 759841 tcggcctgcg gtatttcttt gagaaatatc cttcagcact ggaaatcaca ggtcttgccg 759901 gcagccgccc caaaatgact atctggcttt ggcctccgga cggcgaagcg atggatttgc 759961 ggcattatac aggaaacact cacgtggcca gcgcgtatga aggctttgat gaaatgcgct 760021 ctgatccgac aggcattgcg aacacaaatg aaataagcct ggcgtgcttt tcgcacatgc 760081 cgtctgacga agtcctcaat gcgctggctg acaaatggca ggcgcccccg ctcattgtat 760141 gcgagccgga cgtctattac gaatcaaaag cactcggggt atggagcatc attgacacat 760201 cccatccgct caaaaaagag ctggaagaac agcttgatgc ggcctttctg ttttataaaa 760261 aggaagtaga gcaacgcaga tggtacggtt tttggcatta tggcgatgtc atgcatacgt 760321 atgacccgat ccggcatatg tggcggtacg atctcggcgg atacgcatgg caaaacaatg 760381 agctcgttcc gaccctatgg ctgtggcagg cgtttttccg ctcaggcaga gaggatatct 760441 tccgaatggc agaagccatg acccgccata cgagtgaaac ggacagcttt cacctcggtg 760501 aatatgccgg gcttggctca cggcataatg ttgtgcactg gggatgcggc tgcaaggaag 760561 cgagaatcag catggccggg cttcataaat tctattatta tctgacgggt gatgaccgga 760621 cgggagatct tttgacagaa gtgaaggatg ccgattatgc ccttgtcaaa accgatccga 760681 tgcgcgcttt ttacgagaaa ggcaagcacc cgactcacgc cagaacggga ccggactggg 760741 cggcgttttg ctcgaactgg ctggcggaat gggagcggac cgaaaattcg gaatatctca 760801 aaaaaatcga aacgggaatc aactgtctga agcggctgcc gctccgctta ttatctggcc 760861 cgacatttga atatgatccg gcgacctcga tgcttcatca tatgggagac ggcattgcgg 760921 gcggatatca tatgatcatt gccttcggcg cgccgcaagt gtggatggag ctggctgagc 760981 ttcttgatga ctgggaatgg gaggatatgc tgagtgaatt cggcgaattt tacacactca 761041 gtgatgagga aaaacgaaaa aaaagcggag gcgctcttca tgacgggcat tttcactggc 761101 cgatgttcgc cgccggtatg acagcctacg ccgcaagaaa aaagcaagat cctcatctcg 761161 ccgccaaagc gtggaatctt ttgctagaag ataagctcag ccatacgccg cttccgatca 761221 aaccggagcg catcgagaca tggacgcagc tagaggagct tccatgggtg acaacgaaca 761281 ctgtctctca atggtgttta aatgtcatag cggcgctgga actgatcgga gattcccttc 761341 cggcaaaaaa agaaacatcg ggcaaaaaag gataacagcc ggaatttcat aggagaaatg 761401 gtgcaaaaaa tgaagattgc aagaatttat gtaagcgctt tatattgaga ggggcaaagg 761461 ggaaatgcaa attgaaaaaa gggggactta cgcaacatga aaataagaat gcgaaaaaaa 761521 tggatggcct tgccgcttgc tgccatgatg atcgccggat gcagccattc ggaaacatcc 761581 aattcagcaa gcggttcgaa agatacgatc aaaattatgg cgccgctctt atcgccggaa 761641 agcccaagtg ataagagccc ttcattaaaa gcgctcgaaa aatacacagg caaagagatt 761701 aaggtcacat gggtgcctga ttcatcctac aacgacaaat tcaacatcgt catggcttca 761761 ggagagatgc ctcacgcgat tgtcattaaa gataagtcag ccggctttat caaatctgtc 761821 aaagcagggg cgttttggga gctgtctcct tatttaaaag actacaagaa tttaagccag 761881 gcagatgaaa agattttgaa gaacagctcg gtgaacggcg aggtgtacgg aatctacaga 761941 acgagggatc tgatcagggc gtgtatgatc atcagaaccg actggctgaa aaatgtcggt 762001 ctggatatgc cggaaacgct tgatgatttc tatgaagtgc tgaaagcctt taaggaaaaa 762061 gatcctgacg gaaacggcaa ggatgatacg tacggcatgg tcgtgccgaa atggatggga 762121 ctcggcaacg gaagcccatg ggatgttctg caaatctggt tcggcgctcc gaaccgctac 762181 ggtgttgaaa acggaaagct gattccagat tttacaacga aggaatacat ggatgcgctc 762241 acgtttttta aaaagctcta tgatgagggc ttgatcaata aggactttgc tgtcatggat 762301 tctgcgaagt ggaatgatcc ggttgtaaaa ggaaaagcgg gtgtcatcgt tgatacaggc 762361 tcaagagcgt ctcaaatcca aagcgcgatg gaggaggcgg atgagtcgaa caaggatatc 762421 attgatatcg tcggctcgct tgagggaccg aatggcaagc gcaccttccc gacatctggt 762481 tattcaggca tgatcacgat accaaaatca agcgtcaaaa ccgaaaaaga gctgaaagag 762541 gtgctgtcct tcctcgataa gatgaatgat aaggaagcgc agattctcac gaacaacgga 762601 gtgaagggcc gcaattacga gctcaaggac ggcgtattca cctcacttga aaaaaacaat 762661 aaatctctcc tgtatgagca tgaaggcttg gcacagttca gcatgtcgat tccgaaaagc 762721 gagtattaca tcgaagacca gaaaaccaag ctcttccagc atcgcaagga catcataacc 762781 gaaggagaaa aaatagccgt ctttaaccct gctgagtcgc ttgtatctga tgtctatacc 762841 caaaaaggag cccagcttga caacatcatc ctcgacgcga gaacacaatt tatcattgga 762901 gaaattgatg aaaaagggtt cgatgatgcg gtggagcttt ggaaaaaaag cggcggcaat 762961 gaactgatga aggacttgaa caaattgtac caatcgtcaa aataaaccga tgcgcctgcc 763021 tttcggcggg cgccccggta tcacgaaagg agaacagata tggaaacagt gccgaagaag 763081 agagatgcac ctgttctcac cgctggaaaa ggcatcagct ggatggctgc gctcaaacgg 763141 gacaaatggc tttatcttct tcttattccc ggtctgcttt atttcttgat tttcaaatac 763201 ttgccgatgt ggggtgtgct gatcgctttt aaagactatt cgccatatct cggcttctgg 763261 aaaagcgaat gggtcggctt tgattatttc aaagactttt ttatgaatcc ggattttttc 763321 cggctgctgc gcaacaccct catgctggcg agtctggatc ttttgtttgc ctttcccgcg 763381 cctctcattt tggctctgct tttgaatgag gtaagaaagg ccgtgtataa aagatgtatc 763441 caaaccttta tttacgtacc ccattttgta tcatggacaa ttgtggtcag catcaccttc 763501 gttttcttta ctgtcgatac aggtgtgatc aacaaattga ttatgagcct gacaggtgag 763561 cagatttctt tcttgtcgga tgcagactgg ttccggccaa tgattgtgat gcaaagcatt 763621 tggaaggaga caggctgggg aacgattcta tttttggcag cgcttgctac ggttgatcaa 763681 gagcagtatg aagcggccat catggacgga gcggggcggt tcaggagaat gtggcatatt 763741 acgctgccgg cgattagaag caccattatc gttttgttga ttttaagaat cggcagcttt 763801 ttgaatcttg gctttgaaca ggtgtatttg atgacgaact cactcaaccg cagtgtggct 763861 gacatcttcg acacgtatgt gtacatgatg gggattaccc aaggggcgta tagctacagc 763921 acggcggtcg gtttgtttaa atcagttgtc gggattatct tgatttttgg cgccaattac 763981 attgcgaaaa agtttgatca ggaaggattg ttttagagga gggagaggta tggctgaaat 764041 tcacacgatg cacaacacca aagccggacg ggtgtttgac gtctgcaaca ttctgtttct 764101 cggcggtgtc ggcgcgatta ccattttgcc gtttttatat attatcgccg gttcctttgc 764161 gacagaagcg gaactcgccc agcggagctt ctttattttc ccgaaaacct ttacacttga 764221 tgcttacaag tatgtgtttt cgacaccgac gttccttcga agcatgggcg tgtccatctt 764281 catcacggtg gttgggacgg ctgtacagct gttttttacc ttcacgatgg cgtatccgct 764341 ggcgaaacgg catgtgaagg gacggaatct gctgttgaat ctggtgattt tctccatgct 764401 gttttcaggc ggcatgattc cgacgtacct tgtcgtaaaa tcacttggcc ttttggatac 764461 gtattgggca ttgattctgc cgatggcgat taatccgttc aaccttatta ttatcaaaaa 764521 cttctttcag cagctgccgc gcgagctgga ggaatcagca aaaattgacg gctgttccga 764581 aatcggcgtc ttctggcgga tcgccctgcc tctgtcaaag ccagttattg cgacctttgc 764641 gctgttttat gcggtcggga tttggaatga tttcttccac gctctcttat atatcaatga 764701 cagtgcaaaa tggccgctgc aaatggtgct tcgccaagtc acaattttat cggatttaac 764761 ggcgaccaat ggtgatacga tgcaaaatgc agttccgccg gagcagggaa ttaaactcgc 764821 tgtcattgtc attgcgacgc tgccgatttt ggcggtctat ccatttttac aaaaacactt 764881 tgcaaaagga atgctgatcg gttcggtgaa aggctgagaa agggagtgtt tcatatcagt 764941 acattagatc agattaagat tgcctatatc ggcggggggt cccaaggctg ggccagaagc 765001 ctgatgagtg atttgtcgat tgatgaacgg atgtcaggca cggtggcgct ctatgatctt 765061 gattttgaag ccgctcagaa aaatgaagtg atcggcaatc acagcgggaa cggcagatgg 765121 agatatgagg ctgtttctac tttgaaaaag gcgttatcag ccgcggatat cgtcattatt 765181 tccattttgc cgggatcact ggatgatatg gaagtcgatg tgcacttgcc tgagcgctgc 765241 ggtatttatc agtctgtagg tgatactgtc gggcctggag ggatcatcag gggcttgcgt 765301 gctgtgccga tatttgcgga aattgcccgg gcaataagag actacgcacc tgaatcatgg 765361 gtcattaatt atacaaaccc gatgtctgtc tgtacaagag tgctgtataa agtgtttccc 765421 ggcatcaaag cgattggctg ctgccacgag gtattcggga cgcaaaagct attggcggaa 765481 atggtcacgg aaaggctggg gattgaggtg ccgcggcgtg aggatatccg cgttaatgtg 765541 ctcggcatta accattttac atggatcaca aaagcctctt accgccatat tgacctgttg 765601 cctatattcc gtgaattcag cgcgcactat ggggaatcag gatatgagct ggagggggaa 765661 tgctggaggg acagcgtctt ttgttcggca caccgtgttg cgtttgattt atttgaaacg 765721 tatggcgcca tccctgctgc gggtgacagg catctggcag agtttcttcc cggcccatac 765781 ctcaaacagc ctgaagtatg gaaatttcat ctcacaccta tatcattcag aaaacaagac 765841 agagctgaga aacgacaaga aacagaacgg ttgatcgtgc aacaacgggg cgttgctgag 765901 aaagcttcgg gagaagaagg cgtgaacatc atagcggctc ttctcggatt gggtgaactc 765961 gtcacaaatg taaatatgcc gaatcaaggc caggtcttaa accttcctat acaagccatt 766021 gtcgaaacaa acgcattcat cacaaggaac cgtgtccagc cgattttgtc cggagcgctt 766081 ccgaaaggtg tggaaatgct ggcggctagg catatatcca atcaggaggc agtggcggac 766141 gcaggtttaa caaaggatac tggcctcgcg tttcaagcct tcctcaatga cccgcttgtc 766201 cagattgacc gcagtgatgc agagcagctt ttcaatgaca tgctccaatg catcatgcaa 766261 agctgagctt gccgattagc tctttccggt ttagaaagga aagcattgac catactgata 766321 gtataatcaa gaagtaggtg ctatcaatat gggaaattat ttaagtgttg cggtagaact 766381 ggtctgcggt ttaggcattt tatttatcat cttaaagctt ctcgggaaaa cccaattttc 766441 tcaaattacg ccgtttgact ttatttctgc tttaatttta ggtgaattgg tcggaaatgc 766501 cgtctacgat catgaaatca aaatcaaaga aattattttt gcttcgctat tgtggggcgt 766561 gctgatttat attattgaat ttatcacgca aaaaatgaaa tcatcgcgaa agttcttgga 766621 gggcgagccg aatatcgtca tccgcaaagg ggagcttcaa tataaagtaa tgaagaaaaa 766681 taagatagac attaaccagc tgcaaagcct attgaggcaa gctgggagct tttcgatcca 766741 agaagtagaa tatgcgattc ttgaaacaaa cgggatggtc agcgtgcttc caaaatcaga 766801 ctttgacaaa ccgacaaata aggatttgca gattccttcg aagtccgttt ctctgccgat 766861 cacgttaatc atagatggag agattgtgcg ggataatttg aaggaagcag gtgtggatga 766921 acagtggctg aaacaagaat tgaaaaagaa gaacattgat aagacagagg acgtgttatt 766981 tgcagaatgg cataaaaata agccgctgta tactgtaacg tacgaacaaa gcagatcaac 767041 atgactctta gaaaaaagct tgcagcaagg cgcaagcttt ttattgattg tatgtccctt 767101 gtttgacagc acgtacatgg tacatgctca cttcagtgct gatcagatag tcaggctttg 767161 gtttgccttt gtttgcttta tggccggcga tatgcgcatc gcttttttcc cattgcttcc 767221 agtgatcctc tgattcccag cgaatcatga caacaacttc ttcatcaccg cggcgcacat 767281 ttttctcaag cactgtcaca tcaattaaac cttcttgttt ttcaatgatt ccttcagcgc 767341 tgaaacgttc tatgacttta tctgcaaagc cttctttaac cgtcattttt ctcaactgta 767401 caaacatttg tctcactcca atcattctca catatgaata attgtaaatg aaattcattc 767461 tcaatgtcaa agaaagcgca gggcggaatc gaaccgccgt gcgcaacagt ttattctttt 767521 aataaaaaca catttccgtc ttcgtcctta aattgaacga aggtgcccca ctccatttga 767581 ttgggctcac cgagaaattc tacaccgttt gtcttcattt tctcgtatgt accaaagatg 767641 tcttcgcatt caaacacaat agaagccttc atttgctctg agcctttcat catggctttc 767701 gggtaaatga ctaaacgagt ctcggctcct tttggcgcaa cctccagcca gcttgcttca 767761 ggtcccattg ggtgatccgc tgcaatatca aagcctacct tctctgtcca aaattgcttc 767821 gctttctgct ggtcctcgac atatacagca acagtgccaa tttgtttgat catagggaaa 767881 cctccaagtt gaaaagataa taatactata acctgtttac ggccgaagta acataaaaaa 767941 atcagccggg aaaccggctg attattaaaa tgagcagctt acaacatcga tgtgatttgt 768001 gtctaaggcg aaataaaccc agcggcgccg tgaggaatcc caataaaagc cgccgacgga 768061 tcttctgcca aggatgatcg ggtaaaacca aaatgagcgg ccattggtta accagacata 768121 ggtaaatcgg aaaaggcaag gacgaatggt gattggttca actaacaaaa cggctccttg 768181 agaaccctgc ggttttgggg gtttcgctgg tatttgggaa ggaggaggtc cctgcggcgc 768241 accgccgaag cctgggctgg caccgctgcc aataccaggg ccggagccgc cgccaaagcc 768301 tggaacagca ccaccgccaa tgccaggacc ggagccgccg ccagagcccg gaacagcgcc 768361 gctgccaatg ccaggccatg gatatcggta ttcatattca aaagcaggcc aaggctcata 768421 aaaatgcccc gcaaacatat aaggatcaac ataatacatg tgataacgtc ctttctcatt 768481 gtaaactgta cattgcagtt tatgcgggcg gactcttatt ggtgcattcg cctaaggata 768541 tgaagctgga atgctctcag agagcagaat catttgattt ttctctagtc ttattcacaa 768601 ttccgattta tcattttata atgaaagtgc ttctattacg aaaaaggaga cagaccgtga 768661 atatcgatca attattatat caatatatca tagacaacac tgcggatatt actgagaaat 768721 ggttcagttt gcgttgccag ctaaaaggcg agctatattc cgccagccat ttaagtgaag 768781 aaacgaaaac acttttaacc gagcagcata catttaccaa tataacaatc gcaagcgcat 768841 ttctggagga tcaaaccgat tttcaagaaa acatgacaaa atgggcgcaa aacgttgcga 768901 aaaacagggt agagcaggat gttcaagtgc atgaggtcgt agaagccata tccaattcaa 768961 gaatctcatt ctgggacgca gtcgccacat ttataaaaga gaatcaggag attgtgacaa 769021 atgaggatgc agaccgatgg aaccgcattg tgaatcagtc gttcgataag ctgattattg 769081 aattctccga gcagtaccaa aaattcatgc tgatgaggct tacatctcag caggaactga 769141 tctcagagct tggctgcccg gtcatttcca ttgccgatgg aatcgggata ttgccgctta 769201 tcggctccat tgatacaaaa cggcacaggt cattttagaa acagtgccgg tccgctgtgt 769261 cgagagaaaa atcacaagcc tcgtcgttga tctttcgggt gttccgattg tggataccat 769321 ggtggctcag caattgtaca acctgtctaa aacacttttc ttattaggcg tcaaagccgt 769381 attttcagga attcgcccgg atgtggccca aacatcgatt caattggggc ttgattttag 769441 tgaatatgaa acgtacggca cgctgaagca ggcattagaa aacatgggtg tccgctgtat 769501 tgttgaggaa ttggaagaaa acaaatagga agtttccagg catatgattg tccgtcaccg 769561 ggtgatcata tgcctttttg atttgaacag aaatcaccat tgatttatcg aaaaaaacat 769621 aatattataa ttcttataag aatactgtga attaaaacct attcaacagg ggggaaggtc 769681 ttttggtttc taaatcaacg attgatccgg aagtgattga aaaaatcatc agctcgctgg 769741 aaacactcga tttcggcacg gttcagatta cggttcatga ttctcagatt acccaaattg 769801 agaaaataga aaagcaccgt ttttcgctga aaaggaaaga atcaaaatga taatgtaaag 769861 ggcgtttgtt ttcattaaat tctccttaaa acatatacat atttcatcca atttttatat 769921 aatagacctt taagatcatt ttttaggagg atttttgaca tgcaagctac ggttcacgag 769981 agtaagcaat cgatcatgca acgcattttg acagtctttg tcttcacatt gctgatcgcg 770041 actgtcggcc tttttatcgg ccaatttgtt cctgtcgctt tgatgctgcc gctttctatt 770101 cttgaagtgg cgatgattat tctggccttc tggatgcgca gaagaaaagc ggtcgggtat 770161 gcgtttgtat atacattcgc gttcgtttcc ggcattacct tatttccgat cgtcagccat 770221 tacgcttcca tcgccggcgc ctatgtcgtg ctcgaagcct ttggctctac atttgtcatt 770281 tttgccgtct tgggcacaat cggcgcaaaa atgaagaagg atttatcctt cctgtggtcg 770341 tttctgctgg ttgcggtgct cgcactcgca gtggtaggga ttttcaacat tttcagcccg 770401 ttaaactcag cggcgatgat ggcgtattcc gtgatcggaa ccatcgtctt ttccctttac 770461 attttgtatg atttgaacca aatcaagcac cgccacatta cggaagactt gattccggtt 770521 atggcgttat cgctgtacct agactttatc aacttgttca tcaacctgct ccgcttcttc 770581 ggcattttga gcagtgatga ttaatgaaaa agcgtctgtc attggatagg cgctttttgc 770641 catacatcaa aaaggcaggt ggagtattgg tgaaaaaaca aatgggcgca tatgtatctc 770701 tggcagcagc tatggcgatc gtcggcagtt ctgtcgttgt cggcaagctg atggtcgaac 770761 ggattccggt ctttctttcc tcaggattgc gttttttgat cgcttctgtc gtattgctca 770821 tgctgctgtt ttgcattgaa aaagggtttc cggctttgac gaaaaaagat gtgttcgtat 770881 tactggtgca atcattcaca ggcgtgtttt tgttcagtat ttgcctgctg tatggggttc 770941 aatatacgac gggaacggaa agcggcattt tgacaagcac aacccccatg ttgatcggta 771001 ttttatcctt tttcctgctg agagaaaaaa ttgagaaaaa gacgctgatc ggcattttgc 771061 tggcggtttg cggcgtaatg gcgattaatt tgtttggagc cgggagccaa gacgggacgc 771121 cgcacgcctt attcgggaac atgctgatca ttgctgcagt cattggcgaa gcgttgttta 771181 cattgatggc caagctgcta tccccgcata tttcggcact ggcgatttcg accttcgtat 771241 cgctcttcgg cttcctgttt tttctcccgt ttgctttgtt tgaggcctct tcatttgatt 771301 acagcgtgcc gactgttttg gattggtcgt atgtgctgta ttacgcgctt tttgtcactg 771361 ttttggcgtt ttacttatgg tatagcgggg tgacgaaggt gccggcgggt gtatcgggca 771421 ttttcacatc cgttcttccg gtctcagctg tcattttgtc aggcgtgata ttgaaggagc 771481 catttgagtt tgtgcatttc atcggcattg catgtgtcat cggcggcata tttgttacgg 771541 tcataaagaa aaaacagccg gatgcgtatc cggctgcaga agaaaagacg ctatagcctg 771601 tccggatcgg acgggttttt tagtctttaa acacgctcag cctttcaaaa agatcaccaa 771661 gcatcttcac gaacatgtct ttttcctcgt cgctgtagtt ttccatgaca gcggatattt 771721 tgctgaaatg gccgggcaga aattgctcca ggcgtgcttt gccttctgtt gtcagttcaa 771781 tgctgatttt tcgtttatcc tctgtgtgat gcctgcggct gacaaaaccg tctctcgcca 771841 gcccgtctag caggcctgta attgttgctt tcgtgacatt tgaccgcttg gcaagctctg 771901 tcggacttaa cctatgatcc ttggcatcaa agagcagcat caggattttg aattttcctt 771961 ctgaaagccc tcggccagca aagtaatgct ccatcacatg attcattttt tttgaaatat 772021 caaaaagaga taaaaacaat tcaagagagc cggcgtcaat attggcatac gtttcggcgt 772081 gctctgttat atgcttatat ttcggtaaat gttttaattc catcgcaatt agctcccgta 772141 cattcgttgt gacacgatta taaaggaggg aaaaccataa cgcaacttgg cttggagatg 772201 attgacagct tttcttggga catagtaagg taatatagtt aggcgcctaa ctaatacata 772261 tagagctgaa aaggtggtta ttgatatgaa acatatgtta atagcaggag gcggaatcgg 772321 cggcttgtca gcggccattt ctctccgtaa ggcagggttt tccgtcacct tatgtgaagc 772381 ggcttcagaa aatcgaaaaa caggtgcggg gattcttcag ccgcaaaacg cactggcggt 772441 gttgaaagaa ctgggcgtat tcgaagattg ctgtaagcac ggctttcaaa cagaatggtt 772501 taaaacgttt gatgaacagg ggaatttgct gtttcaagtc agtgaatcct ttttagacga 772561 ttcacttccg ggacgcaata atatcctgcg caaaacgtta aatgacattc tcatgaagca 772621 tgccgaggca gtgggtgtag acatcaagtg ggggaaaaag gttgtcgcct atgaagaaac 772681 tgctgaatcg gtcactgcct tatgtgaaga tggagaaaag atgcaggctg acattctggc 772741 gggctttgac ggcattcact ccgttgttcg tgataagatg ctgcaaaagg aaacggaaaa 772801 agagcatctc ggcatgggag cgtggcgctt ttatatcgaa cttcctgatt acacattcga 772861 ggacgcaaca ttcatgtata gaagcggaga cacacaaatc ggggtggtgc cattggcaca 772921 acacgctggc tatgtcttcg tcctccagcc ttgcacgagc gattactggg atgaggaaga 772981 tacccggttt gatagagtaa aagagattct ttctggtttt cgggggctgg attttgtcac 773041 aaagcacatg tcaaaacagc atcctgtcat ctttaacaaa ctggagcagg tcgccgtgca 773101 ggagccatgg cataaaggcc gcgtcatcat cggaggagac gccgcccacg ccggtgcgcc 773161 aaccctggca caaggagcgg caatggcgat cgaggatgcc atcgtcctcg ccgaagaact 773221 ccaaaaccac gccgaccacg aaacagcatt acaggcgtac tataaaagaa gagccccacg 773281 agcgctcaaa gtccagaacc tatcatctga aatcgtccgc cgcaggctga aaggagagcc 773341 gggagcggaa gaactgattg gggagtgcta tgcggtgttg agggaagggt attaaatagg 773401 aaaagtccag aaagtgattt ctggactttt tagtcttgct ctgttttatt ccttatccgc 773461 tcaatcacct catgcagccc ctcaggctta taaaactcca ccggtgaact gcctttctca 773521 aacgaaatcg tctcggcttc aatcagcgcg acatagcgcc cgtttacttt tgcgagatga 773581 atagaatcgc caaaatccgc tagcaatccc ttaatctctg tttctccgac tttcattttc 773641 agctgggcct ctggcgtgtg ctcgatgatt tgggcggagg cttcgatgac ttgatgggtg 773701 tcgaggcgct cttggatttc ccgtttttcg cttgcttccc aaatctcaat gtcgtgctcg 773761 aactgcttga gttcttcgct gttgtcttca aatgtctcgt agacgtgctc ttgtaccatg 773821 ttcatgacct gatttttcat gatttctggc atcgattctc cgtactcgac gaatttcaga 773881 aagtcctcaa aatagcgggc gtgcgaggcc tggtggattt tcagttcacc ttcctcgacc 773941 attccttcct ctggcatgta cgggtattgg atgcttttca tgttttttgt cgtgatcgcc 774001 atttcgactt ttttaatgag agaagacgcg tcagagatgc gggcgacctt cggctcaaaa 774061 tcacatttca taatgaagac aaatgactca tcaaagtatt ttctcggcac ggccgaagcg 774121 acgagaaaca cgccgccgcg aaccgcgctt gtgtcaaggt acgtgcggac gaactgctcg 774181 ctcagctcat tgaagtcttc ttttgtttcc gccagacgcg cgcggttgaa catgttgtag 774241 tttgggttgg aatcgagctc gtggccgggc tcgacgataa aatggccgat tttcgtcggc 774301 acctgctcgg actgcggatg gcggtcggct ttccgtttaa cgattttttt cagttccccg 774361 tcgagaaagt ccttcagctc gctttcttca aattctcccg tatcaagggt ctggaagtgc 774421 ttgaactgct tgttcgcctg ctcatctttg ccttccacct gtatgacata aaaggataaa 774481 aaccgaattt caaaatccat atataaactc accttattcg cgtattgtac agcttctcaa 774541 gtatagaaaa aacagcgatc atgcgtcaat tgggagaacg gaataatcat gaccatgaaa 774601 gggaaatgta gtcaaataga aggcatttca tacggaaagg aatggttcga tgaaggaaac 774661 aagcccgatt cctcagccga agacgtttgg gccgctcggc aatttgcctt taattgataa 774721 agacaaaccg acgctttcgc tgatcaaact ggcggaagaa cagggcccga tttttcaaat 774781 ccatacaccc gcgggcacga ccattgtagt gtccggccat gaattggtga aagaggtttg 774841 tgatgaagaa cggtttgata aaagcattga aggcgccttg gaaaaggttc gcgcattttc 774901 cggtgacgga ttgtttacga gctggacgca tgagcctaac tggagaaaag cgcacaacat 774961 tctgatgccg acgttcagcc agcgggccat gaaggactat catgagaaaa tggtcgatat 775021 cgctgttcag ctcattcaaa aatgggcaag gctcaacccg aatgaagcag tcgatgtccc 775081 gggagatatg acccggctga cgctcgacac cattgggcta tgcgggttta actaccgctt 775141 taacagttac tacagagaaa cgccccaccc gtttatcaac agcatggtgc gggcgcttga 775201 tgaagcgatg catcaaatgc agcggcttga tgttcaagat aagcttatgg tcagaacaaa 775261 gcggcaattc cgctatgata ttcaaacgat gttttcgtta gtcgacagca ttattgcaga 775321 gcgcagggcg aatggagacc aggatgaaaa agatttgctc gcccgcatgc tgaatgtgga 775381 agatccggaa actggtgaaa agctcgacga cgaaaatatc cgctttcaga tcatcacgtt 775441 tttgattgcc ggccatgaaa caacgagcgg cctgctttcc tttgcgactt actttttatt 775501 gaagcatcct gacaaactga aaaaggcgta tgaagaggtc gatcgggtgc tgacggatgc 775561 agcgccgacc tataaacaag tgctggagct tacatacata cggatgattt taaatgaatc 775621 actgcgctta tggccgacag ctccggcttt cagcctttat ccaaaagaag acacagtcat 775681 tggcggaaaa tttccgatca cgacgaatga cagaatttct gtgctgattc cgcagcttca 775741 tcgtgatcga gacgcttggg gaaaggacgc agaagaattc cggccggaac ggtttgagca 775801 tcaggaccaa gtgcctcatc atgcgtacaa accattcgga aatggacaac gggcctgtat 775861 cggcatgcag tttgcccttc atgaagccac acttgtgtta ggcatgattc taaaatattt 775921 cacattgatt gatcatgaga attatgagct tgatatcaaa caaaccttaa cacttaagcc 775981 gggcgatttt cacatcagtg ttcaaagccg tcatcaggaa gccattcatg cagacgtcca 776041 ggcagctgaa aaagccgcgc ctgatgagca aaaggagaaa acggaagcaa agggtgcatc 776101 ggtcatcggt cttaacaacc gcccgcttct cgtgctgtac ggctcagata ccggcaccgc 776161 agaaggcgtc gcccgggagc ttgctgatac tgccagtctt cacggcgtaa ggacaaagac 776221 agcacctctg aacgaccgga ttggaaagct gccgaaagag ggagcggttg tcattgtgac 776281 ctcgtcttat aatggaaagc cgccaagcaa tgccggacaa ttcgtgcagt ggcttcaaga 776341 aatcaaaccg ggtgagcttg agggcgtcca ttacgcggta tttggctgcg gcgaccacaa 776401 ctgggcgagc acgtatcaat acgtgccgag attcattgat gagcagcttg cggagaaagg 776461 cgcgactcgg ttttctgcgc gcggggaagg ggatgtgagc ggtgattttg aagggcagct 776521 tgacgagtgg aaaaaaagca tgtgggcgga tgccatcaaa gcattcggac ttgagcttaa 776581 tgaaaacgct gataaggaac gaagcacgct gagccttcag tttgtcagag ggctgggcga 776641 gtctccgctc gctagatcgt acgaagcctc tcacgcatcc attgccgaaa atcgtgaact 776701 ccagtccgca gacagcgatc gaagcactcg ccatatcgaa attgcattgc cgccggatgt 776761 tgaatatcaa gagggcgacc atcttggcgt attgccaaaa aacagccaaa ccaatgtcag 776821 ccggattctt cacagattcg gtctgaaggg aaccgaccaa gtgacattgt cggcaagcgg 776881 ccgcagtgcg gggcatctgc cattgggccg tcctgtcagc ctgcatgatc ttctcagcta 776941 cagcgtcgag gtgcaggaag cagccacaag agcgcaaata cgtgaactgg cgtcatttac 777001 agtgtgtccg ccgcataggc gcgaattaga agaactgtca gcagagggtg tttatcagga 777061 gcaaatattg aaaaaacgaa tttccatgct ggatctgctt gaaaagtatg aagcgtgtga 777121 catgccgttt gaacgatttt tagagctttt acggccgtta aaaccgagat actattcgat 777181 ttcaagctct ccaagagtga atccgcggca agcatcgatc acagtcggtg tcgtgcgcgg 777241 cccggcgtgg agcggccgtg gcgaatacag gggtgtggca tcaaatgatt tagctgagcg 777301 tcaagccggt gatgatgtcg tgatgtttat ccgcacaccg gaatcccggt ttcagcttcc 777361 gaaagaccct gaaacgccaa ttattatggt cgggccaggc acgggagtcg cgccatttcg 777421 cggtttcctt caagcccgcg atgttttaaa gcgggagggc aaaacgctcg gtgaggctca 777481 tctctatttt ggatgcagga acgatcggga ttttatttac cgagatgagc ttgagcggtt 777541 tgaaaaagac ggaatcgtca ctgtccacac agccttttcc cgaaaagagg gcatgccgaa 777601 aacatatgtc cagcatctca tggctgacca agcagataca ttaatatcaa tccttgaccg 777661 cggtggcagg ctttatgtat gcggtgatgg cagcaaaatg gccccggatg tggaggcggc 777721 acttcaaaaa gcgtatcagg ctgtccatgg aaccggggaa caagaagcgc aaaactggct 777781 gagacatctg caggataccg gtatgtacgc taaggatgtc tgggcaggga tatagataaa 777841 gaagactgga gacatccagt ctttttagtc ctttcgaaaa aatggtgatc gcgctaaaca 777901 ttgatgcata caataacttc agtccgccgg aagggcgggc tgtctgcaaa acctattttt 777961 cgtttttgct agtttatgtt attcttatac tcggtatcta tttctttttt caaaggcaca 778021 catgacaaaa gaaatccttt ttttatttcc gagaaaaaaa tgtgaaacga aatgaaggtt 778081 tctttcgtcc agtgattggt ttccaaatgg ttgtaataaa aatgatatgg tgcgaaacat 778141 aaatattccg gcttgccgcg gtgtatttat tgttgtgtga tgccttgatt ttgtttggaa 778201 agaaggaatt ggaaggcagg atataaagag caggtaaata tgaatgaaga acttaaagtg 778261 tttaagaaag tagaggttgc catgaagaaa cttttttctt acaaacttag cttttttgtg 778321 ctggctgtta tactgttttg ggcaaaaacg tatttatcct acaagactga gtttaatctt 778381 ggggtaaaag gcacaactca ggagatcctc ctgatattta acccattctc aagcgccgtc 778441 ttctttttag gactggcttt gctggcgaaa gggcgtaaat cagccattat tatgctgatt 778501 atcgatttct tgatgacatt tgtgttatat gcaaatattt tattctatcg tttctttgac 778561 gatttcttga cgttcccgaa cattaaacag tccggaaacg ttggaaacat gggagacggg 778621 attttcagta tcatggccgg tcatgatatt ttctatttct tagatattat cattttgatt 778681 gcggtattga tctggagacc tgaattaaaa gaatacaaaa tgaaaaaacg ctttgcatct 778741 ttagtgatcc tttctgggat cgcactgttt ttcatcaacc tgcactatgc ggaaaaagac 778801 cgtccgcaac tgctgacaag aacgtttgac cgcaattata ttgtgaaata tttaggttta 778861 tacaactaca ccatttatga cggtgtacag acggctcaaa cagagacgca aagagcctat 778921 gcaagcagcg atgatttaac aagtgtcgag aattacacga cgtctcatta tgcgaaacca 778981 aacgccgagt acttcggctc tgccaaaggc aaaaatatca ttaaaattca cctcgaaagc 779041 ttccagtcat tcctgattga ctacaagcta aacggtgaag aggtgacgcc tttcttaaat 779101 aaacttgcgc acggcgggga agatgtgacg tattttgata acttcttcca tcagacaggc 779161 cagggaaaaa catctgatgc cgagctgaca atggataact cgatcttcgg tcttcctgaa 779221 ggctccgcgt ttgtgacgaa aggcgaaaac acctaccagt cgcttcctgc gattttagac 779281 cagaaggaag gctatacaag cgccgtcctg catggtgatt acaaatcgtt ctggaaccgt 779341 gaccagattt acaaacatat cggatatgac aagttcttcg acgcaagcac gtatgatatg 779401 tcagatgaaa atgtgattaa tatggggctt aaggataagc cgttctttac agaatcgatt 779461 ccaaagcttg aatctcttaa acagccattt tatgcgcatt tgattacatt gacaaaccat 779521 tatccgttta accttgatga aaaagacgcg tctcttaaaa aagcgacaac aggcgataac 779581 acagttgaca gctacttcca gacagcgcgt taccttgacg aagcgcttga gcaattcttc 779641 aaggagctga aggaagccgg cctgtatgac aactcagtca tcatgattta cggtgaccat 779701 aacggtattt ctgaaaacca taaccgagcg atgaaagaga ttcttggaaa agagatcaca 779761 gattatcaaa acgcacagaa ccagcgtgtg ccgctgatga tccgcgttcc tggcaaaaaa 779821 ggcggagtga accatacgta tggcggcgaa attgacgtca tgccgacact tctgcactta 779881 gaaggaattg attctcagaa atatatcaac tttggtactg atttattctc taaagaccac 779941 gacgatacgg tggcattcag aaacggagac ttcgtaacgc cgaagtacac atcagtcgac 780001 aatatcattt acgatacgaa gacaggtgaa aaactgaaag cgaatgaaga aacgaagaat 780061 ctgaaaacaa gagtgaacca gcagctgagc ctttcagaca gtgtcctgta caaagacttg 780121 ctgaggttcc ataaactaaa tgatttcaaa gccgttgatc cgtcagacta tcattacggc 780181 aaggagaaag aaatcaaata agatgaaaaa gagccttgag cgggcgcatt gccttcgctc 780241 aaggctcttt ttttggttat acaaccaact tgaaaaaata gattccattt ggtcaccaag 780301 gctggctttc tctcatatca ttacagtaga ttttgaaacc ggattgaaat cggacaaatt 780361 atcggggaaa tgccttgata gattgtgaag atgtaccagg tttcgaactc aatattcata 780421 gagatgaggg gtagagatga aagcggtcat tctctgcggc ggaaaaggaa cgagaatgag 780481 tgaagtcacg aatgacattc ctaaaccgct cgccatgata ggcggcaaac cgattctatg 780541 gcatattatg aaaatttatc agtactacgg agtaaacgag tttattctgc ttttgggcta 780601 taaaggagaa aaaatcaagg aatactttct cgactatgaa tggaagcaca acagcctgac 780661 actcgacagc tctacgggag aggtacagat gctggggcag cctgaaacgt ggaaaattac 780721 gtttttggag actggggtag atacgctgac agccggaaga atcttgcagg cgaaagacta 780781 tatcggtgat gaaacatttc tgctcaccta tggagacggg ctggccaata tcaatctttt 780841 ccatctcatc agctatcatc agacaaaagg tgctgccgcg actgtcaccg gcattgacaa 780901 agtctcgcag tttggcacct tgacagttga ggatggcatg gcgaaaacat tttctgagaa 780961 gacatcaagt gatggaatca tcaacggcgg attcttcgtt cttagtccaa aggttttcga 781021 ttatttgccg aaggacggga acacgatgtt cgaagatgaa ccgctgaaga accttgccaa 781081 agatggggag cttgctgtgt accgccatta cggattttgg acggccatcg atacgtataa 781141 aaatctctta gaagtcaaca aaatgtggaa tcaaggacaa caagtatgga aggtatggtg 781201 aattgatttg agtttctgga aaaataaaaa cgtatttgtc acgggatgca caggtctttt 781261 aggaagctat ttggtgaaag agctgatcga acagggcgca aacgttacgg ggctagtcag 781321 ggatcatgtg cctcaatcca atctttatca gggagaacat atcaagaaaa tgaacatcgt 781381 gcggggctct cttgaggact tggctgtgat tgaacgcgcg cttggcgagt atgagatcga 781441 cacagtcttt catcttgctg cacaagcgat tgtcggcgtg gcaaaccgca acccgatttc 781501 tacctttgaa gcgaatatcc tcggcacctg gaatattctc gaagcctgcc gcaagcatcc 781561 gttaattaag cgggtcattg tcgcttcaag tgataaagct tacggcgatc aagaaaacct 781621 tccatacgat gaaaacatgc cgctgcaagg caagcacccg tacgacgtct caaaaagctg 781681 cgcagatctg atcagccaca cctattttca cacgtacggg cttccggtct gcattacgcg 781741 ctgcggaaac ttatacggcg gcggagattt gaacttcaac cgcatcattc ctcagacgat 781801 tcagcttgtg ctgaacgggg aagcgccgga aatccgaagc gacggcacat ttgtacggga 781861 ctacttctat attgaagacg ccgttcaggc ttatctgctt cttgcagaaa aaatggaaga 781921 aaacaatctt gccggagagg cctttaactt cagcaatgag atccagctga ccgtacttga 781981 actggtagag aaaatattaa agaaaatgaa cagtaatctg aaacctaagg tgctgaatca 782041 gggaagcaat gaaatcaaac atcaatattt atccgcggaa aaagcaagaa agctgctgaa 782101 ttggacaccg gcctacacta ttgatgaggg acttgaaaaa acgattgagt ggtatacgga 782161 attcttcaaa aagtaatgtg aaacgaggtg aacaagactg tgaccagcgc gtattgcacc 782221 gttttatcaa aaggaagatt atatcaggca gtcgctttgt ttaagtcgtt agagcaagtt 782281 gatcaagaca gtcccatttt tatactttgc atggatgaag atacgcaccg cgtgttacag 782341 aagctgaaga tgaagcagct gaaccttgtg ccggtggccg ctcttgaaaa tgaattgctg 782401 ctgaagctga aggaaactag agatcaaagt gagtattgct ggacgatgaa gccgatcttt 782461 ctgcaagctg tgctgaacag caatcctgag ctggagcgtg tgacgtatat tgacggggat 782521 ctctttttct atgcagatcc atcgccgatt tttgaaaacc agccggactg ctcggtgttg 782581 ctttcacgag gggatattgt aatcccttct tttgagaaag agcagattga catgctgcag 782641 cgtcttttag gcagatataa ttccgggttt atcagcttca agcatgatga tgcaggcacg 782701 gattgcttgg agtggtggaa ggaacgctgt cttgaggaat gcaaaaatgc accgggtgaa 782761 gggaaattcg gtgatcaggg ctatttggat tatatgtctg agctgtttcc gaatgtgtgt 782821 gacattacaa cacccggcgt gaacatcggc cattggaatt atggacagca tacgttttcc 782881 tggaaagatg gccggatcgt gctggaggat ggcagtccgc tgatctttta tcatttcagc 782941 ggataccgaa tcgtcagcat caatgaaatc aaacagattc atgaaacaac ccgcacagat 783001 ctgccgtttg tgcatgaact gtatcaagag acactgccgc atatcattca gcacatgcaa 783061 acgttagacc ctgaatttaa cggttttgct tcaaaagatg acaacaaata aatgagtaaa 783121 tacaggaagt gaaaatgaag tgaaagcaag cgttattatt cctgcatata attcgaagga 783181 gcgtctttac aacagccttc tgtcattaaa ccagcaggag tgcgatgaag aatttgaagt 783241 cattgtagcg gacaatggct ctgaggacgg gacgctctcg atgcttgagt catttcaagc 783301 tgattttccg ctgatcttta cacggattaa agaaaacagg ggcattgcgt acggacgaaa 783361 tcaggcgctt cgcaatgcca gaggagacat cctgattttc catgacagcg atatgcttgc 783421 ggcaaaggac cttgtggcaa aacatattaa agcccatgag aacgaagaga atctcgtcgt 783481 gtgcgggttg ttttggaaac ggatctacag tttttactat gaacgatttg aagaagaaca 783541 taaggaacag ctcgcaaagc tcacaggtga aatgccgaag aaagacaaac aaaagctgct 783601 ggaggaagcg gacatcaaaa acggaagctt tcttgataaa agctttgacc tcgataccga 783661 ctttatagac gtgctcaaga agattttaga tgagtacggc gatgacttga aaggctatca 783721 tatgccatgg cgctttttta tcacgaataa ttcctctgtg aaacgcaagc atgtggttga 783781 cctcggttta tttgacgaag gcattgtgcg gtacgggttt gaggattatg acctcgggat 783841 caggcttcat caggccggat tgaccttcag gcttcgccgt gatattgtca gtgttcatca 783901 ggaacatcca agcaattgta agtctgtaga cgatattcgg gcaaacattg cctatatgtg 783961 cgataaatac aataacatcc gctccttaga cgttcatctc gcttttaatg ggccgttccc 784021 gcctgacatg acgaacagaa tcatggctga tattcaaaag ctgctggaat cacagaaata 784081 tgatatgctg ctgaatctgt ttcttgagct tctgcatgtt gttaaagagc gcaacattga 784141 tccggattgg cgaaagaaat ccccaagggt gacggcgaaa agctttgatt tgcaaactgt 784201 ccgcaagctt ctgcctaagg cgaagaaaaa gctaggcgtg aacgattttg ccaacgcact 784261 gtatgcgctt gtcaacgatt tgctgcacgt ggatcttaga tcattggatg tggtataagt 784321 gagtacattt catttttcaa cgatagtgtc aaggacacat atctttaagc tcatgcctat 784381 gattcattct ctccatgagc attgcgatga ttttcattta tatgtgctgt gtgtcgacca 784441 gaaagcgtat gaattgcttc agcacgttcc atgggagcat gtaacctttg tgcagctgca 784501 tgaaatggaa gacccggagc tgttgaaagc gaaaagcaac agaacgtttc atgaatattg 784561 ctggacgtta aagcccgcct ttttgtttca tgtgatgagc aagtgggatg acgctgaata 784621 ctttgcccat atggatacgg atctattttt cttttctgat ccggcacgta tttttgcaga 784681 aaacccaacg gcgtctctgt atttgactga tcatcgtaat tcgccgcgct tcatgtccta 784741 ctacgaccga accggacgct ttaatacagg ctttgtcggc gccggtaata caaaggaagc 784801 atatgaagcg gtgtggcagt ggagacagga ctgtattgaa ttttgcacgg tcgaaatgga 784861 tacggaacga aagacatatg gtgatcaaag atatgtggag aaatggccgg agcagtttaa 784921 aggtgttcat gttgtcaaat ccataggagc caatacagcg ctttggaata tcgaaaacta 784981 taaggtcggg caaaaggacg gccgcgtgta tatagatgaa acgccgctga ttttctatca 785041 tttctctggg tttacgctgg tgacagaaaa agagtttaat ctttgctggt actaccggat 785101 tgaagacgaa gcgacaatta agatgattta tatgccctat atattaaatc tgaaaagatg 785161 gattgatgaa atacagtcgg cgtttccgga ctttgcggat ggctttatcc cgaagcacgc 785221 agtgcctgac actcatttta tccagctgga ttaaaaaacc ccctgccgcc tggcaggggt 785281 tttttcagct atgccattct ctcagcttct ggtcacttgg caataggaag gcaaggatgc 785341 cgaggacagg gagaaaggca atggcgatca tcgtcggggt cagtcccgcg gcatcaatca 785401 gagcgcccag cgccacagcg ccgattgcgc ccatcccgaa ggcaagcccg acggttaaac 785461 cggacattgt gccgattttt ccaggaacta gctcctgtgc gtagacgacc gttacagaaa 785521 agctcgacat cagaaccaag ccaatcaatg cgagcacgcc gtaggcgaga accgggccgg 785581 caaatggcag cacaatcgcc agcggcgccg agcataacag cgaaccgagg ataacgaagc 785641 gttttccaaa acggtctgca agcgggccgc cgagaaacgt gccgatcgcg ccgaacagca 785701 agaagacaaa aatatagctt tgtgcctgct gaatgcttac gtgataggta tccatcgcgt 785761 aaaacgtgta aaagttaccg atcgcactcg tataccaaga acgagcaaaa atgagaaata 785821 taataataat aagagcagat acaacagatt tggtgatggc cgtgttttca gccgttttct 785881 tttgcttgcc tgatttctgg gcaaggctgc cgagacgtga ggcgtaccat ttcgcaatat 785941 acatgagaaa cataacagca agcgcggcga caagcgtgaa ccaaacagcg ccgaattgcc 786001 cgagcggcac aaggatcagc gcggtgatca gcggtgccat cgcctggcct gagtttccgc 786061 ccacctgata aatcgattgg gcgagcccgc gttttgtgcc ggcggccata tacgccacac 786121 gggagccctc cggatggaaa atggccgagc ctaatccaat gaaaaacaca cagcataaga 786181 tcgttatgaa tgacggggca aatgcaaggc ccaaaatgcc aagcatgctg gcggtcaaac 786241 cgactggcag cgcatacggc cgcggccgtt tatcggtata ccagccgaca acaggctgca 786301 tgacggatga caccatgttt aatgtgaaag caatgatgcc gagctgtgta aacgtcaggc 786361 tcatggagcg ttccaaaata gggaacatgg ccggaatcac agcctgaagc gaatcgttga 786421 gcatatggca aattccgata ataatcaaaa tcggatacac cgtggtgcct ggtttttgaa 786481 ctgttttttc ttttaacggg gcggcgatag ccattgagtc tcctccttac atatataacc 786541 aaagcatacc accatattat tcataaggtg aagaatttat caagaggaaa aaagattctt 786601 atgaaagaaa taccgtcagc ctgattagca gctgacggta ttttcgatat tcaaaatgtg 786661 atatagctct tcaagcttac gaatctcata ggttggtatg atctctggca cattcggctt 786721 catgtcaggg ttcatccagc aagtatcaag cccggcgagc tgtccgcctt tgatatcagc 786781 agttagtgaa tccccgatga ttaatgtgtg ctctgctgaa aattgaggaa tccgttcaaa 786841 cacgtaattg aaatattcct tcatcggctt ttggaagccg gtgtcttcag aaacgaaaat 786901 gtccttgaag aatggaaata atcctgaatc acggagacgc ttatattgtg tgtgagacac 786961 gccgtttgtc acgatgtaca aatcaaactg ttgctgcaga tttgagatga gatcaaatgc 787021 accgtcaata agctgatgtc cttcttcaag aaagcggcgg tatttttgct caagcaaagc 787081 gccgtccgct tcgtaaccgt actccttgag caaagcggaa aaacgtgtgt ttacgacttc 787141 atcccgtgtc atcttacctt cttcaaaggc tctccagaga ccttgattga tggttttata 787201 ctgcgccttc atgtcatttg ttaaaggaat gttctgatct tcaaacagca aacgcagggc 787261 taaagcttct gccgcttgaa aatcaaggat ggtatcatct acatcaaata ataaagtgcg 787321 gtatcgcttc atctgtgtgt ctccctttct catatgtatt caaagtatag cacataaaaa 787381 aaggaaaaag ccggcgggtg aggcaccgcc ggctgaaaag agattatttg tttaataagc 787441 tgtgttttct cgaatatagg aagtaaacca gcgttccgac agcgatccag atgacaaatg 787501 aaagccatgt gacgccggga aggctgtaca tgaaccaaag gcagatgcct gcgctgataa 787561 tcggcacaac cggaacgaat ggcactctga aggacgcttt gatttcagga tgtttctttc 787621 ttaacacaat gacagcaatg gaaatgaccg taaacgcggc aagtgttccc atgttcacca 787681 gatgggccag cgttccgagg ttaataaagc cggcgattcc cgctgcaacg atccctgtca 787741 gccatgtgtt gcggaacggg gttttaaatg acggatgaac ctttgcgaac aatccaggca 787801 gaaggccgtc tctgctcatg gcaaatgtca agcggacctg tgcgtacagc aaagcgagca 787861 tcaccgtcgt aatcccgata atcgcaccga cagaaataat tccggcaaca gcgtcctgtc 787921 cgacgaattt cagcgcaaag gatacaggat ctccgacatt caatttggca taaggcatca 787981 tgcctgtcag cacaagcgat accgcgatgt acagaaccgt acagacggct agagctgaaa 788041 taatgccgac gggcatgttt ttttgcggat ttttcacttc ctctgatgcg ttagaaaccg 788101 cgtcaaaccc aaggtacgcg aagaatacag tggcagcgct aagtatgacg cctttcatcc 788161 cgaatggcat aaaaggagac cagttatccg gtttcacata gccgatgccg acaataatga 788221 acaataatat gatcgcgatt ttcatcagta cgatgacgtt gttaaagcgt gtgctttcct 788281 tgacgcctct gctgacaatc gcagtgatga ggagaatgat caccgcagcc ggaaggttaa 788341 atacggcgcc cgccatgctt cccggcgctc ctgtcagtgc agccggaata tgaagattga 788401 agccggcaag cagtgattga aagtatgaag accagccggt ggcaaccgcc gacagtgcaa 788461 tgacatattc aagcatgaga tcccatccga tcaaaaaggc gagcagctct ccaagtgtca 788521 cgtatgagta tgagtacacg cttcccgaaa tcggaatgga agacgaaaac tcagcataac 788581 agaaagcagc cagcgcacag gcgagccccg ctaaaataaa cgatatgatg agggcgggac 788641 ctgcaccggt cgctgccact gttcctgtaa tgacaaaaat ccctgtaccg atgacacaac 788701 cgataccgag caaggttaaa tcaaatgcgc ttaacgtacg ggcaaggctt tttgacttgc 788761 tctgcgcact caatgtttca agcggttttt ttctaaataa tgaactcatc aaaagttcct 788821 cctagaaata ttcaaaatat tctaatcatt atatgcagtt cttgttgtat tatattgtcg 788881 aaatttgacg tagtcaataa aatatttttc tgctttaaat gatagaagcg aaacagcgtt 788941 gtcgtatcat aggatagtaa tttttactaa tcgtatattc aattttatgc aagatgaacc 789001 gatagaaaaa atagattcgc ccatattttg atttgcggtt ataaaggaga tgctgaccat 789061 gtttcaatat gaagagttga ataaacagtt tatcggcggg aaatggcagg agggcagcag 789121 cccaaatgta ttggaaaaca aaaatcctta tactcaaaaa acattcacaa cattccgtaa 789181 agcgactgct gacgatgtag atgaagcgta tcgggcagcg gcgctggcaa agaaaaaatg 789241 ggatgcggtc aacccgttcg agaaaagaac cattttagaa aaagccgtca cgtatattga 789301 agaaaatgaa gaagccatta tttatttgat tatggaggag ctaggcggta caaggctcaa 789361 agcagctttt gaaatcggtc ttgtcaaaaa catcataaaa gaagcggcaa cgttcccaat 789421 ccgcatggag gggaaaattc ttccgtcaac aatagatggc aaggaaaaca gattatatcg 789481 cgtgccggca ggcgttgtcg gtgtcatcag tccgtttaac ttcccattct ttttatctat 789541 gaaatcagtg gcgcctgcac tcggagccgg caatggcgtt gtgctaaagc cgcatgagga 789601 aacgccgatt tgcggcggaa cgctgattgc gaaaattttt gagaacgcgg gaattccagc 789661 ggggctgctg aatgttgttg tcacagacat tgctgaaatc ggcgacagct tcgttgagca 789721 tccagtgccg cggatcatct catttaccgg ttctacgaaa gtcggcagct acatcggaca 789781 gcttgcgatg aagcatttta aaaagccgct tcttgagctt ggcgggaaca gcgccttcat 789841 cgtacttgag gatgcagata tagaatatgc ggtcaatgcg gcggtgttca gccgatttac 789901 acatcaaggg cagatttgca tgtcagccaa ccgcgtgctt gttcattctt ctatttatga 789961 caagttcctt gagctgtacc aggcaaaagt ggaatcgctg aaagtcggcg acccaatgga 790021 ccctgatacg attatcgggc cattaatcaa cagcagacag acggacgggc tgatgaagac 790081 tgtagagcaa gcaattgaag aaggcgctgt accagtgaag cttggcggat ttaacgggac 790141 gatcgtggaa ccgacgatct taaaagacgt caaaccgttc atgagcattg ccaaggaaga 790201 gctgttcgga ccagtcgtct cctttatgaa gtttgattca gaagacgaag cggtggatat 790261 cgcaaacgaa accccgtttg gcttgagcgg tgccgtacat acgtcaaatc ttgagcgcgg 790321 cgtggctttt gcgaaacgca ttgaaacagg catgattcac gtcaatgaca cgaccatcaa 790381 tgatgaaccg aatgtagcct tcggcggtga aaagcaatca ggcctcggcc gtttaaacgg 790441 tgagtggagc ctcgaagaat ttacaacgct gaaatggatc tcggtccagc acgaaaaacg 790501 cagcttccct tattaatgaa aaggagtgaa tggaattgac cataaatacg gaaaaagaaa 790561 ccgcagatat tctggacgca tttatcaaag tagcccctta tttaaacagc ctggttcagg 790621 atgatattac aatcggcatt tatgatacgg aaaaactgct cgtgaatata ccggccaaaa 790681 ccttttcgct gaacgtaaaa gccggcgatc cgctgcagga aggggatatc atcacagatg 790741 ccatccgcag caatcagaag aagacgagca tggttccgaa agaattgttc ggcttcccat 790801 tgatcgcgcg tgccatcccg ctgcacgacg agaatggaag agtcattgga ggcgtcggcc 790861 tcggaacgag ccttgaggag tcgtcaaagc tgcatgatgt cgcggaaagc ttatcagctg 790921 ttgttgaaca aacagccgcg gctatttccg acatttctga atcaattaac gggttttcaa 790981 ctcaaatgtc gggcatttcc tctcaggcga aaaaagtaag cgaaagcgcc ggtgaaatcg 791041 ccgatatttc agtaactgtt aaaggcatct cggaccaaag caatctgctc ggcttgaacg 791101 ccgcgatcga agcggcaaga gcaggggagt ccggaaaagg attctctgtc gtcgcagatg 791161 agatcagaaa gctagcgacg cattcaaaag aaaatgtcgg ccaaattgac cagattacga 791221 aaaaaatcca cagcctgctg aaagggctgg aggaatccat tgagtcgatt aaccagcata 791281 cagacggaca agccgctgct gttgaacaaa tttccgccac gatgcaggag atttcaggaa 791341 gcgcgcagca tcttgcgaaa atggccgaaa aagcgcttga ggaagagtaa gagaccgggg 791401 acaaacatcc ccggtctttt tcttatcctg catttccatg aaattcgtct gacgttttac 791461 tagttttatt ccagcggctg atttaaaatg tacacatgaa cttacgtgag gattgatagg 791521 aaccatgagc atattaaaag cggaaaatct ttataaaaca tacggagata aaacattatt 791581 tgaccatatc tcctttcata ttgaagagaa tgagagaatc ggattaatcg ggccgaacgg 791641 aacaggaaaa tcaacgctgt tgaaagtgat tgccggcttg gaatctatcg aagaaggaga 791701 aatcacgaaa tccggaagcg tgcaggtcga atttcttcat caagacccgg agctgcctgc 791761 ggggcaaaca gtgctggagc atatctattc cggtgaatcg gctgtgatga aaaccttgcg 791821 tgaatatgaa aaagcgctgt atgaactggg gaaagatccc gaaaatgaac agcgccagaa 791881 acacctgctg gcagcacaag cgaaaatgga cgcgaacaat gcatgggatg caaacacctt 791941 ggcaaaaacc gtattgtcta agctgggcgt caacgacgta acaaaaccgg tcaatgagct 792001 ctcaggcggc cagaaaaaac gggtggccat tgccaaaaac ttaattcagc ccgctgattt 792061 gctcattttg gacgagccga caaaccattt ggataatgaa acgattgagt ggcttgaagg 792121 gtatttaagc caatatcccg gcgccgtcat gctggtgacg cacgatagat atttcttaaa 792181 ccgtgtcacc aaccgcattt atgagcttga aagaggcagc ctctacactt acaaaggcaa 792241 ctatgaagtg tttttagaaa aacgcgcgga acgggaagcg caggctgagc aaaaggaaac 792301 gaagcggcaa aacctgctgc gccgcgaact ggcttggctc agacgaggag cgaaagcccg 792361 ctccacaaaa caaaaagcga gaattgaccg ggtagagacg cttaaagagc agacaggccc 792421 tcagtcatca ggttcactcg attttgccat tggctcgcac cgtctcggaa aacaggttat 792481 tgaagcggag aacgtcatga tcgcttatga cggccgcatg ctcgtcgacc gttttaatga 792541 acttgtcata ccaggtgaac ggatcgggat catcgggccg aacggcatcg ggaaaacaac 792601 gctgttaaat gcccttgccg gccgtcatac gccggacgga ggcgatatta cgatcggaca 792661 gacggtcaga atcggctact atactcagga tcatagtgaa atgaacggtg agttaaaagt 792721 cattgactat ataaaagaaa cggcggaggt cgtaaaaacg gcagatggcg atatgattac 792781 agctgaacaa atgctcgagc gtttcctctt cccgcgttcg atgcagcaga cgtatatccg 792841 caagctgtcc ggcggggaaa aacgccgttt atacttgctt caggttctca tgcaggagcc 792901 gaatgtcctg tttctcgatg agccgacgaa cgatttggat actgaaacat taagcgttct 792961 tgaggattat attgaccagt tcccaggcgt cgtcatcacc gtatcccatg accgctattt 793021 ccttgaccgc gtcgtcgacc gtttgattgt atttgaagga aatggtgtca tttcccgctt 793081 tcaaggctcc tatagcgact atatggagga gtcaaaagcg aaaaaagcgg ccccaaaacc 793141 ggcagctgag gaaaaaacgg ctgaagccga gccgaagaaa aaacggaaaa agctttctta 793201 caaagaccag ttggaatggg acggcatcga agataaaatt gcccagctgg aagaaaagca 793261 tgaacagctt gaagctgaca tcgccgcagc aggcagtgat tttggcaaaa tccaagagct 793321 gatggccgag caggcgaaaa cggcggaaga gcttgaggct gcgatggacc gctggacaga 793381 attgtccctc atgatcgaag aactggaaag ctaaaaagcg tggccgcagc aggccgcgct 793441 ttttttcaca taatggacaa aaacgaaccg gcctgcttat gttaggataa agttgtgtgt 793501 cagcggcaca tggaaaacta acggagatga tgaagtatga catgggcgat cgtgatgtta 793561 attctcatga gtctggtgaa aatcgtatta acctgtcttc ctacaggcgt catagaatgg 793621 ctgctcggca aatttgaagt gcacgccaag ctgagtgacg aaaatgcgag tctctctcta 793681 gatggaaaac gcctcgaggg tgcagagaag cagaaagtga ttgatcaatt taacgaagct 793741 atcttcctgg aaaaatatta tatctatcca ggtgatgaag agcgttattt acatccggaa 793801 aacggcggca cgcctctggt gatagataca aaaaaaggaa aaaaagacgt gaagctgttc 793861 gtgtaccgct acgacgacca tatcgacgtc gtgaaacagt acaagaagaa agtgatcgcg 793921 tatcgagtgc tttctgaaag ccttcaaaaa gagtctctgt cagtggcggg aagtttagct 793981 taaacaggaa agtgaaagac gggtgctgta tgctgctcgt cttttttatt gttttttaaa 794041 acttaacgtt tacgttaagg ttcaaaaggt gtataatggt aacagaaacg gcgaaggggg 794101 atttaccttg gaatggatga agattgatca agtggccaaa agaagcgggc tgacaaagcg 794161 gaccatccgg ttttatgaag aaatcggctt gattccggcg ccgaaacgga cagacggcgg 794221 tgtaaggctt tattcagagg atgatatgga ggagcttgag aaagtcatca gcacaaaaga 794281 ggtgctcggt ttttcccttc aggagcttca gcatttcatg gaaaccagcc gccagctaga 794341 gttaaacaaa gaggggtatt tgttgtcact ggatcctaag gaacggaaag aaaaactgga 794401 ggaaattcag gaaaccctga atcaccagct ggatttgatt gatgagaaaa tccgcacatt 794461 ccaaagcttt aaagaacgcc tgcagggcat gaaaggcaaa gcggaacgcg ccattcaatc 794521 aatcgaatga aaagtttgtt aaacgctatt tttgtagcgt ttcttttaat ggaataaaga 794581 tggaggttag gtcaaatgga taagacaaca caagtgaatc agaaaacggg tttgctcagc 794641 cagccaaaag cggtatgggc tgtcgcgttt gcctgtgtga tttcttttat gggaatcggg 794701 ctggtcgatc caattcttcc ggccattgcc gcacaattgc atgcttcacc tagtgaagta 794761 tcactcttgt ttacaagtta tttgcttgta accggattta tgatgttttt ctcaggagcc 794821 atttccagcc gcatcggcgc gaaatggaca ttaattctcg gacttatttt tattattgtg 794881 tttgcggggc ttggcggcag ctcaagctca atcgctcagt tagtcggcta tcgcggcggc 794941 tggggattag ggaatgcttt gtttatttca acagcgcttg cggtcatcgt tggcgtgtca 795001 gtcggcggca gcgcccaagc gattattttg tatgaggccg cgctcggtct cgggatttct 795061 gtcgggccgc ttgcaggcgg agagctcgga agcatttcat ggcgcgcacc gttttttgga 795121 gtatctgtcc tgatgtttat tgcgttaatc gcgatttctt tcatgcttcc gaagctgccg 795181 aaaccggcga aacgcgtcgg tgtgtttgat gcgatgaagg cactcaaata taaaggcctg 795241 ctgacaatgg cggtatcggc attcctatac aactttggat tttttatttt gctagcttat 795301 tctccgttcg tactggattt agatgaacac ggtcttggat atgtcttctt cggctggggc 795361 cttctgctgg cgattacgtc agtctttacg gcgccgctcg tgcacaaagc gctgggcaca 795421 gtgcgttcgc tagtcgttct ctttatcgcc tttgcggcca ttctcgttat tatggggatc 795481 tggacagacc atcagacttt gattattaca tgtatcgttg tcgctggtgc tgtcctcggt 795541 atggtgaata cgatcatgac aaccgctgtg atgggttctg cgccggttga acgttcaatc 795601 gcgtcttcag cctacagctc agtccgcttc atcggcggcg cgctcgcccc gtggattgca 795661 ggaatgctgt cagaacactt tactgcaagc acaccatata cagtaggcgg aatcgtcgtt 795721 tttgtcggca tgcttgtcct tctcatggga cgtaaacatc ttgctggaat taaggcgggg 795781 cattaataac gaaagacact gcgcatatgc agtgtctttt tattcgttat aatgcatcat 795841 aatcgaattg gtgcaggaaa ggacaacctt tatgacacaa ttttactatt ttccggctga 795901 aaactccctt tagaaaccgg ttttttcggt cagcaagaac ggcgttcgcg gaaagggcat 795961 ccgcttcggt caggcattga tgcggctggg atttatcttg cagaagctga gaatgtgtcc 796021 gttcatttac gattgccatt tcagtgatgg ttcatgctgt agaggggacg tttgccatgg 796081 ataaggcaaa acctgacgaa tatgatcaga aatgtttaga aacgctctat caatacatac 796141 acagcgtcat gaaaaacagc ttttctcggt cgagtggttt accgcttggg aagatgagga 796201 ggattttgag ctgtctgcca aaagagagct gacacttgat gaattcacat ctccattgca 796261 gctcatttta aaagacagag agcttttgag aatcgttcag aaaaaatggc agtaaaaaac 796321 ccgcccttta gcaggcgggt ttttttataa attaaagcac tttcgtcgtc caagactcgc 796381 agttccacgt ttctgtcgca atatccatat aaaagtctgg ctcgtgggaa atgagcagaa 796441 tggagccttt atattctttc agggcgcgct tgagctcttc cttggcatcg gcatccaagt 796501 ggtttgtcgg ctcatcgagc accagcaggt ttgtttctga gttgattagc ttgcacaatc 796561 tgactttcgc tttttcgcct ccgcttaata cggagacgcg gctttcgata tgctttgtcg 796621 tcagcccgca ttttgccaga gcggcacgga tttcatactg cgtataagaa gggaattcgc 796681 tccatacttc ttcgatgcac gtattgttgt ttgtttcctt gacctcttgc tcgaaatagc 796741 cggtatagat gtgctcaccg cgttcaacag agccttcgag cggctggatt tcaccaagca 796801 aacttttcag caatgtcgtt tttccgatcc cattcgcgcc gtaaagggcg attttttggc 796861 cgcgctccat gcggaggttg agcggacggg acagcgggga atcgtaaccg atcacgagat 796921 ccttcgtttc aaaaatcagc ttgcctgacg ttctcgccgg cttaaagtgg aattccggct 796981 ttggcttttc tgccgcaagc tcgatcatat ccatcttatc gagtttcttt tggcgggaca 797041 tcgccatgtt tctcgtgctg acacgcgctt tgttgcgggc gacgaaatcc ttcagctccg 797101 cgacttcctg ctgctgcttt ttgtaggccg cttcaagctg ctgttttttc acctcgtaga 797161 cttccataaa ctgatggtag tcgccgacat aacgtgtcag ctcttgattt tcaacgtgat 797221 aaatcaggtt gatgacacta ttcaagaacg gaatatcgtg ggaaatcagg atgaacgcgt 797281 tctcgtattc ctgcaggtag cgtttcagcc attcaatatg ctgttcatca agatagttgg 797341 tcggctcatc gagaagcaga atttccggct tttcaaggag aagcttagcg agaaggacct 797401 ttgtgcgctg tccgccgctc aaatcggtga catctcgctc taaaccgata tcgctcaaac 797461 cgagaccgcg ggcgatttct tccaccttgg aatcaatgac ataaaaatca ttgtttgtca 797521 gcgcgtcttg aatgacgccg acttcttcaa gcagcttctc gagctcgtcg ggatcagcct 797581 cgcccatttt gttgtaaatc tcgttcattt cctcttccat cgcaaataaa taatggaatg 797641 cgtctttcag gacgtcgcga atggattttc ctttttccag cacggtatgc tgatcaaggt 797701 atccgacacg gacatttttt gaccattcga cttttccctc atcaggttca agctttccgg 797761 taataatatt catgaaggtt gattttcctt caccgtttgc gccgatcaag ccgacgtgct 797821 cgccttttaa caggcggaag gaaacgttat taaaaatggc ccggtccccg aaaccgtggc 797881 ttaaatcctt tacagataaa atactcatgt ttacacctct atcgttatca aacacgcaca 797941 atcggcgtgt aatattcacc cttttgatta taaaggagga ttcggaatgt tgaaaggtat 798001 aggaaagaaa aagaaaaatt gcgttccggg cgaggttttg agatactatg gaatagattt 798061 caggaattga ggagaacaaa atgacgcaaa cttggccatt tttacataat gcacaatcat 798121 ttatacaaga gaattggaat gcttccggct ttcaaaagcc aacccctgtt caggagcagg 798181 cagcccagct gatcatggac ggaaaggatg tcattgcaga atcgccgaca ggcacaggga 798241 agacgctggc gtatgcgctg ccggtcttgg agcggatcaa accagagcaa aagcatccgc 798301 aggcggtgat tttagcgcct tcccgtgagc tggtcatgca gatttttcag gtgattcagg 798361 attggaaagc gggctcagag ctgcgcgcgg cttccttaat cggcggggcg aatgtgaaga 798421 aacaggtcga aaagctgaag aaacatccgc atatcatcgt cggcacgcca ggcagggtgt 798481 ttgaactgat taaagcgaag aaactcaaaa tgcatgaagt gaaaacgatc gtgcttgatg 798541 aaacggatca gctcgtcctg ccggagcatc gcgaaacgat gaagcaaatc attaaaacaa 798601 cattaagaga ccgccagctt ctatgttttt ctgccacgct caaaaaggaa acagaggacg 798661 tgctccgcga attggcgcaa gagcctgagg tgttgaaggt gcagcgaagc aaggcggagg 798721 cagggaaagt gaagcatcaa tacctgattt gcgaccagcg cgacaaagtg aagctgctgc 798781 aaaagctgtc aaggcttgaa ggcatgcagg cactcgtatt tgtgagagac attggcaacc 798841 tgagtgtata tgcggaaaaa ctggcatatc accacgttga actcggcgtt ttgcacagtg 798901 aagcgaaaaa aatggagcga gcgaaaatca ttgccacatt cgaagacgga gagtttcctc 798961 ttttattggc gactgacatt gccgcacgcg gtttagatat tgaaaacctg ccatacgtga 799021 ttcatgctga tattccagat gaagatggct atgtccacag atcaggacga acaggccggg 799081 ccggaaaaga aggcaacgtg ctgagccttg tgacaaaatt ggaggaatct aagctgaaaa 799141 aaatggcgaa gaagcttggt gttgagctga gtgaagctgt gtatgcaggc ggaaaactga 799201 agacgaaata aaaagaaggg cgaagagccc tttttttgtt gtaaaataat agaaaagatt 799261 ttgcgcggag gtgggaaaat ggcttcaata gacaggtttc aagtaatgca ggagccagag 799321 ctgaaaatcc ttgaacactg gtttgagaat gaggatacca gacggagaat ggatgggatg 799381 ctgctattag atgagtggta tgcacgagta aataaagata aacacgatac tgtcatcatg 799441 gcgtatgatg gacagctgcc ggcagggatg gtcgttattg agttcggaga ggagcggaca 799501 tatattggat tgatcgtcaa tcctttgtac cggcttaaag ggtatggaaa acagatactg 799561 caaaagctga tgaccgaacc tgattttact agcgtgcgag aatgggtggc atgcattgaa 799621 gaagacaatc gaatcagttt agcttgcttt caagcagcag gattcacttt agaagacacg 799681 gaacctgatg aagatggttt tcttacgctg attcttcgca actgatctca tcgaaacaca 799741 aaaggagggc aaaaagccct cccgttttca tcttcattca gctcggatca ctgaccttga 799801 tcagctgttt ccctttattt tctcccttaa ataaaccgag aaacgcgtca ggaatgtttt 799861 cgaagccttc tgtgatggtt tcctcgtaat ggagtttacc agccttcagc cattctgcca 799921 gctgttttgc tccctcagaa aaacgatcgg agtagtcgct tacgataaag ccttgcatca 799981 gcgacttcgt tttaatgagt tttgattgga cacgagggcc catgtcatct gcttcgcttt 800041 ctgcgttata ggaagaaatg gcgccgcaca ccggaatgcg ggcaaattca ttgagcagat 800101 tcatcaccgc gtctgaaatc ggtccgccga cattgtcaaa atacacatcg acaccgtcag 800161 gacaagcgtt ttgaagcgct ttttggatat catccgctgt tttgtaattg atggcttcgt 800221 caaactgaag ctcctgtttt aaatagtcga ttttttcatc agagcccgcg atgccgacga 800281 ctcgcgcgcc tttgattttg gcaatttgcc cgactgttga accgacggct ccggcagctc 800341 ctgagacaac cacggtttcg ccttccttcg ggcgtccgat gtccagcaat ccgaagtatg 800401 ctgttaagcc ggtcattccc aaaatgccga gataggccga agcgggagca aggcttgtat 800461 caatttttcg caaggcagac tcgctcacag cggaaaattc ctgccagctg agatttccga 800521 tgacgatatc gccttttttc agatgattcc cgtctgacac aacttcagcg ataacccctc 800581 cagaaagcgc tttatccaag gcgaacggct caacatatga cttcgtatcc tgcatacggc 800641 cgcgcatata agggtcaacc gatacataaa gcgttttgac aagcacttcc ccttgcttgg 800701 gttcaggaac cggaatggtt tcaaagcgaa agtcttcatg aacaggaata ccttgtggac 800761 gtcttgctaa ttgaatttgc tgctgagatg ctgtcatttt catcctccta tcacttggtt 800821 gacaccactg taacatggac aggagaggaa atacaaaagg taagctggca tacaaaaaag 800881 gttatagatg agcttatgct ttctacaagc tcttttgttt taaaagttct ctttagtcat 800941 ttatcattat tagaaaacag aacagaaaaa gagctcctgt acacctagct aagattggct 801001 agtgtgtatg tcgattcttt ttcatattct tgcaagcatc tgcgaggggg agcttagtcg 801061 ttcacatttt gctttcgcat caatctgcaa tagcaaagtc tatgcgattt ttttacatca 801121 gcaaagattt gttcaatttt ttccttttat gccgagtttt tctgaaacag ataattgatg 801181 gtactcaacc attttctttt ggtcaataaa gtaatgttta cttattaatt aaacacgcga 801241 aaaagcaaac gaaaacataa ttaaatttta tatatttatt aaaagcttat atgtttattt 801301 accttttttt tgaattgtaa ttgagaaaat ccatatattg cggacactaa taaaagaata 801361 cctgctgaaa cataaactaa acgaactcca aggaaatctg aaatagcccc tatagccaga 801421 attgaaaaca taaaaatgaa ctgtactaaa gaagaccttg cagacattat attaattcga 801481 gtttgctcgg ttgttatgtt ctgaataagt gtttcttgtg taagatctct taatatataa 801541 gccggcccca taaagagaac caaaattaga gctaagtatg aattacttat aaaaccatat 801601 attaaagtta aacttccata tgagacagcg ccaattaaca taaaattaat taacttattt 801661 tgaaatctct ccgacagctt atatattata aatcccccta tcatcgaacc taaataatat 801721 gctccattaa taaatcccca ccatgattct cctttatgca agacttcgtt aacgaaagct 801781 aaagagacag atcctatcca aatcattcct gcccatgact caattaaatc cataataata 801841 attgttctaa gtttcttttg gctaaataaa taccgccaac cacttactat actcttattg 801901 ggagaatttt tttcacgtat gacagaatta gcgtggccat gtggtagaca aaataaaaga 801961 gaaagaagag atgtaaacaa caaaaagata gtaagtataa tggtatatcc ctcacctaaa 802021 aatgcaatta tgagaccacc taaagaccag cctacaaatt gaaaagtttg gtccactgta 802081 gataataatc catttgcttt tactcttcta tcaggagaga ttatttcccc tataattgca 802141 ctttttaaag gtgagaacca tccattaaaa aaggaaatac agctaataat aataaagact 802201 aaaatgagag tttgattaga gtaagttctt aataaagcat agaacaaaca tattaataac 802261 agcatttgta tcaattgaga aataattatt gtaagaggca gttttaatcg aattgttatt 802321 aacggtaata tagcacttcc aaaaatacga aaaataatac ttattaatgt caccatagag 802381 gcgatggttg tcgaattggt cattttaaac aaaaacgaaa tcactaccat agtatataga 802441 gaaaaaccta aatttgtagt ggtctggcta aataaaatag aataataacc tttactcata 802501 tgtatcctcc cttggaataa tttttctcgg taaagagctt aaacatattt aaacacctta 802561 aaacaacaaa agtaaagaaa aaatttcctt gtaaactatt tacttttatt ctatttattg 802621 ttattgttta tttaagttct ctgactattc tatcaatatt cagggaacca catatcttat 802681 taaagggggg aaaaccatga gaaaattaag aaaaaactgg agaaaatcga ttgttagccc 802741 ggttctttat actaatgaaa aatggtaaac acttagggaa tagcatttaa tgctattcct 802801 tatttcaaca aacaaatcgg gaggttatcg taatttgact ctattaatgc aagatcataa 802861 atcaatttac aataaagata tagaaatatt aattgaagtt gaagaactta ttacttctgt 802921 tccagaaaat aaaaaaaatg attttaagag tttaatcgat aatagaatta tgactctact 802981 aaataaaatt caacaccctg tagcagcgga aaatgtgttt gggatgtgta ttgcttatcc 803041 gaatacttac ataaggtata gattaattga tttcgttgaa aaatgggtac cttatttctc 803101 tgctgtagaa actataatca atctaaccca ggatccggat gatttagttt cttttaaagc 803161 tatggatgtc tgtgcaaatc ataaaattga agaatctgta gcatatttgt cttcgattat 803221 tgatgatgtc cgggagagta taagctaccc taaaaaacct gtgggattag gggcccaaaa 803281 agtattaagt acattattag atatattcgg tgttgaaaaa catgaagagc tagtaatgct 803341 aaaaaattat tttgatcaaa atggtatact tcctaataac tttgactttg aagaaaaaat 803401 tcctcaaagt ctaatagagg aattcgaaaa aacagaagaa gatgggatga ttttaattcc 803461 gggtggcttt tttgaattcg gtttaaatga aaatgaaatt cctgacaaaa catttaattg 803521 gaaagatgct gttcctagac aaaaagtatg gttacctcca ttttttatcg ataagtatcc 803581 tgttacaaat aaagattatg atatctttac cgagttcata gaggaaaatg ggcatatatt 803641 ctgtcatcct aatgaaccgc agaataaaca acatagaaga aatacatatt gggatgatag 803701 gtatttagat aatcatcccg ttacaggtat agatttttat gatgcatttg cttacgcaag 803761 atataagggg aaagaattgc caaccgagtt tcaatgggaa aaagctgctc gaggcgaaaa 803821 gggtaatgtc tggccttggg gagataaatt tgatcctgca aaggttcaat atgctggaag 803881 tctttataat gaacccatta cttctttaaa gtcctggaga gaaaatttat taaaagctca 803941 tgctgataaa gaattaaatc atttaacaag tgatattttt gaacaaaatg gtgaaagtcc 804001 ctatggagta tgcggtatga tcggcggaac atgggagtgg actagaagtg agcttaaaac 804061 aaagagagct ttccacccta tttttgagaa tgtaccattt aatagtgtta actcatttgc 804121 cgttcttaaa ggaggatcat tcttctctca tccaggctta atgttccctt cttttagagc 804181 aaaagatatt cctttctgtc gacacaatga aatggggatt agatgcgtaa agaatattcc 804241 agtatataaa attagagaat caattaatgg gccaattact aataaagcaa tttattaatc 804301 attctaggtt agagacttga taaaagtata ctaacattgt gtagtaatgt tcagcttgta 804361 gaaaaaacaa tgttttttct acaagatttt attttaaatg cttttcaaaa ttatcaggga 804421 ttgagaatca gaaaaagagc cattaagctc gatcttagct aggtattacg atcttctgta 804481 tattattgtg agaaatatag aagattcagt tagttagcat ttcgatttta agctgagcct 804541 gcaatagcaa agcatctgtt ttgattattc tttttctgat acataagcta attttgtcgc 804601 ttttcttttt tgtcttttca cgcatttcga ggatgactta ctataattct ttcagctttt 804661 ctatgtgtta agattcgaat agatgaaata actttaacaa gttggtcaat aagaacagat 804721 ttaactttat gttaaaagag tatctcgtat agaacataag aagaatgacg agttttttaa 804781 gattatcatc aattatgtga gaataaaata ttataaggga aaatgaaggc tgtcacgttt 804841 ctcgacagcc ctagggaatt cctctccttt tcatttcgcc cgtaatttcg ggcacagtcc 804901 cgtcggcagg cacattggct tctggtcgat cgggcttctc atgatgcagc attccaagcc 804961 gaagacttca cggaaaaatg gctgggtgaa cacatcttcc ggtgttccgg cgttgtatat 805021 ttttccgtcc agcacactga tcagatagtc agcatattga gcggcttggt ttaaatcatg 805081 gagcaccatg acaacggtgc ggccatggtc gcggttcagc tttttcagca gttcaagcac 805141 ttcaatctga tgtgagatgt ctaaatacgt ggtcggctca tcaagcaaaa gcaaatcagt 805201 gccttgcgca agtgccatgg aaatccaggc tctttgtctt tggccgcctg agagggcatc 805261 aagtgtccga tccttcagtt caatcatgcc cgttgcttcc agcgcccact ctaccatgtc 805321 atgatcctct tgggtatgct tggataacag ctttttgtga ggatgtctgc caaaatagca 805381 taattcctct accgtcaatc cttcaggagc ctgaggagat tgtggaagaa tggccagttt 805441 ttttgcgact tcttttgatg gctggcggtg gatgtctttt ccttctagta gcactgtacc 805501 gctttttggg gccatcagcc tggcgagcga tttgaggatt gttgatttac cgcagccatt 805561 agcgccgatg agcgcagtga tttttccttc ttctatcttt aagtcgactc cgtcaataat 805621 cactgtactg tcatatgaaa gagtgagctg gtctgcagcc agttttccca tggtatcctc 805681 tccctactgt ttcctcgctt cgaatttcaa taaatataag aaataaggcg cgccgatcac 805741 ggctgtcagt attccggcag gtatttcaac cggaggcatg atgccgcgcc ctaacgtatc 805801 tgcaattaat aatataatag caccaatcaa tgccgatgca ggcagtaaat atttagcttt 805861 ttctccggta agccgtctgg cgatatgcgg agcaagcaag ccgataaaac cgattgagcc 805921 gacgacggct acacagcttc ccgccagcgc caccgcggtg aaaatcagga tgaatctcag 805981 ccggtttgcg ttttctccga gaccctgtgc aagctcatcc ccgagtgaca taagatccag 806041 cttcggtatg agtatgcaga cgatcggaaa aagaatcaaa agccatggcg caagcagctt 806101 gacttcttcc cagtttcttc cccagaggct tcctgtcagc caaatgagtg cagcattcac 806161 gtcgcctgga aacttgacca tcatatattg cattccggcg tggcagaccg cgcctaaagc 806221 aatgcctgat aaagccagtg aagagggctg aatgctcttt tttcgggcta tcattaataa 806281 tagtacagca ataatggcgg ctccggcaaa tgcggagaac ggaagcacgt ataccggcga 806341 ctcaggaaag atgagaatca cagccatcgc cgcaagtccg gagccttttg aaatgccgac 806401 aacgtccggg gaagcgagcg gatttcggat cacaccctgt aaaatcgctc cggcagcggc 806461 aagtccagca cctgccaaaa tcgctaatat aatgcgggga aggcgatatt gctggatgat 806521 aaattcaaag gaatgatcca gtcccagcag attcgtcact accgcatcag gtgaaatgta 806581 taatgcaccg attccaatgc tgatgacgga cagaacgatt aaaatcacgg ccaatatgag 806641 tatcgccagt aaggggcgtt tttgttttct ggttgttttc ttcatttcag gtttcgccct 806701 ttccttgcca aatataagaa aaacggcgtt ccgataatcg cggtgacaat gccgaccggt 806761 gattcataag gaaatgcaat ccatctggcc agaacatctg cgtacaccag caaaatggca 806821 ccgaacagtg ccgaaaacgg aagcacgtat tgataatgtt ctccgatcag cttgcggaca 806881 atatgcggga cgagcagccc gacaaagcca atcggcccgg cgacggctac ggaagcgccg 806941 gaaagaatta aaataatcaa actgatcaga atcctgatgc cgttcatatt ttgtccaagc 807001 ccttttgctg tttcgtctcc gagaccgaga acagaaacag aaccggaaaa tacgagggca 807061 agcccgatgc caatgacaga aaaaggagcg atggttatga cgtcctgcca gttgctgccg 807121 tcgattgcgc ctgtcatcca gtacagaaca tcctcacctg actcatttaa aataatgatg 807181 gcctgtgtca tagaggagag gaacaagtgc acggccattc ctgacagcgc cagcttgaca 807241 ggcgtcattc cgccggatga ggcaatcata tacacaatcg cgccgcctgc tgccgcaccc 807301 gcaaaagcga atataacaga tgaatagggc gatgccggca gaatgacgag agaagcaaca 807361 acaaaaagcg atgcacccgc attcacaccg aaaatttggg gtgaagccag aggatttctg 807421 gtcatagcct gcatcagcgc ccctgctaca gctaggctgg cgccgacaaa aacgccgatt 807481 aatgtgcggg gaaggcgaag agtagagatg atgagctgtt cctttgaacc gtcccataca 807541 aaaagatatt tcaatgaatc tatgatgctg atgtctgagg ctcctactga aagattcagc 807601 ccaagcccaa atataaaaat aatcagtgca atgataaaca tcatcagtct tgatgatgag 807661 cgccgtttgg ctgaatgata caacagtctc acttccttac tgcgtctggt tgcaaaaacg 807721 aagaagcaag gattcccctc gcttctcatt tgtcctattt attatacact tttttaagca 807781 catctttggc gcttgtttca ctagacttga tgcctctgaa tcttgtccaa gtgtcacggt 807841 ccgcatcata gacttgtcca tttttcaccg ctttgagatt tttccagagc gggttcgttt 807901 tccactcatc tacaatggtt ttgccttcgt tggctgagat gaacaaaata tcaggatcga 807961 ttttgctcaa ttgctcaagg ctgacctctt gataggcgtt atctgacttc acagcgtgtg 808021 taaagcctag cattttaaag atttctccgt cataggatga tgatgtatga agctggaagg 808081 aatccgctct tgcaacgccg agaacgatgt tgcggttttc atctttcgga agttcggctt 808141 ttagatcgtt gatgactttt ttgtgctcgg caagcttttc ttttccttca tcttctttat 808201 ttaatgcttt agcaatggtc gtaaagctgt cgatcgtttc gtcatatgtc gcttcacggc 808261 tttttaattc aatcgtcggg gcgatttttt tcagctgttt ataaatgttt ttatggcgct 808321 cagcgtcagc gatgattaaa tcaggcttca aggaactgat gacctcaaga ttgggttcgc 808381 tgcgtgtgcc tacagatgtg taatcaatgg agctgccgac aagcttttta atcatatctt 808441 ttttgttgtc atctgcgatg cccaccggcg taatgccgag attgtgaacg gcatccaaga 808501 atgaaagctc aagcacaacc acccgcttag gtgtgccgct tactgtcgtt tttccttctt 808561 cgtcatggat cactctggaa tccttagact cgcttttgcc gcttccgttg ttattctggc 808621 ttgatgaaca gccggataca atgaggcagg cgagcaataa aacactcatg atggcaatca 808681 acttgttaga ataggtgcgc atgtcattct tccttttttc agatttagta atgagaatca 808741 ttatcacatg taacactata atagcatggc ttatcatgtc aatatttttt tagtaaagaa 808801 agctgcgttt ttactgcttt ctcatgaaag catcatcaga cacaaataag tggtatgcag 808861 cgttaccgtg tcttcgagac aaaaacgcat gggcgttggc tttagaggtt tcgaacatat 808921 cagcagtgac ataaggaagg agagtgctga gataaccgga caatttcttt tctatttcat 808981 ctgttagtgc aaattcaatg tcgccgatat tcatgataat cgagaaaaca aagtcgatat 809041 cgatatgaaa atgttcctcg gcaaaaaccg caagctcgtg aattcctggt gaacatccgg 809101 cacgcttatg gaaaatctgt ttgactaaat cactcacaat ccaagcattg tattgctgtt 809161 ctggtgaaaa gtattgcatt agacatacct cctgctcgta cggataaagg cagcgtttca 809221 tggtcgtgtg ctccgtgcag cggcttctcc ttaattttga tttttctgaa aataggtccc 809281 gttcctatca ctttaccatg gacggaaaac aaatagctac taccattcct cctgtttttc 809341 tcttcaatgt tctggaatct gtttcaggta cagacgatcg ggtatgaaag aaatatagaa 809401 aacatgaagg aggaatatcg acatgaaacc agttgtaaaa gagtatacaa atgacgaaca 809461 gctcatgaaa gatgtagagg aattgcagaa aatgggtgtt gcgaaagagg atgtatacgt 809521 cttagctcac gacgatgaca gaacggaacg cctggctgac aacacgaacg ccaacacgat 809581 cggagccaaa gaaacaggtt tcaagcacgc ggtgggaaat atcttcaata aaaaaggaga 809641 cgagctccgc aataaaattc acgaaatcgg tttttctgaa gatgaagccg ctcaatttga 809701 aaaacgctta gatgaaggaa aagtgcttct ctttgtgaca gataacgaaa aagtgaaagc 809761 ttgggcataa agcaaggaaa aaaccaaaag gccaatgtcg gccttttggt ttttttgcgg 809821 tctttgcggt gggattttgc agaatgccgc aataggatag cggaacattt tcggttctga 809881 atgtccctca atttgctatt atatttttgt gataaattgg aataaaatct cacaaaatag 809941 aaaatggggg tacatagtgg atgaaaaaag tgatgttagc tacggctttg tttttaggat 810001 tgactccagc tggcgcgaac gcagctgatt taggccacca gacgttggga tccaatgatg 810061 gctggggcgc gtactcgacc ggcacgacag gcggatcaaa agcatcctcc tcaaatgtgt 810121 ataccgtcag caacagaaac cagcttgtct cggcattagg gaaggaaacg aacacaacgc 810181 caaaaatcat ttatatcaag ggaacgattg acatgaacgt ggatgacaat ctgaagccgc 810241 ttggcctaaa tgactataaa gatccggagt atgatttgga caaatatttg aaagcctatg 810301 atcctagcac atggggcaaa aaagagccgt cgggaacaca agaagaagcg agagcacgct 810361 ctcagaaaaa ccaaaaagca cgggtcatgg tggatatccc tgcaaacacg acgatcgtcg 810421 gttcagggac taacgctaaa gtcgtgggag gaaacttcca aatcaagagt gataacgtca 810481 ttattcgcaa cattgaattc caggatgcct atgactattt tccgcaatgg gatccgactg 810541 acggaagctc agggaactgg aactcacaat acgacaacat cacgataaac ggcggcacac 810601 acatctggat tgatcactgt acatttaatg acggttcgcg tccggacagc acatcaccga 810661 aatattatgg aagaaaatat cagcaccatg acggccaaac ggatgcttcc aacggtgcta 810721 actatatcac gatgtcctac aactattatc acgatcatga taaaagctcc attttcggat 810781 caagtgacag caaaacctcc gatgacggca aattaaaaat tacgctgcat cataaccgct 810841 ataaaaatat tgtccagcgc gcgccgagag tccgcttcgg gcaagtgcac gtatacaaca 810901 actattatga aggaagcaca agctcttcaa gttatccttt tagctatgca tggggaatcg 810961 gaaagtcatc taaaatctat gcccaaaaca atgtcattga cgtaccggga ctgtcagctg 811021 ctaaaacgat cagcgtattc agcgggggaa cggctttata tgactccggc acgttgctga 811081 acggcacaca gatcaacgca tcggctgcaa acgggctgag ctcttctgtc ggctggacgc 811141 cgtctctgca tggatcgatt gatgcttctg ctaatgtgaa atcaaatgtt ataaatcaag 811201 cgggtgcggg taaattaaat taagaaagtg aaaaacacaa agggtgctaa cctttgtgtt 811261 ttttaattaa ttaaaatgtt tattaactta gttaaggagt agaatggaaa aggggatcgg 811321 aaaacaagta tataggagga gacctattta tggcttcaga aaaagacgca ggaaaacagt 811381 cagcagtaaa gcttgttcca ttgcttatta ctgtcgctgt gggactaatc atctggttta 811441 ttcccgctcc gtccggactt gaacctaaag cttggcattt gtttgcgatt tttgtcgcaa 811501 caattatcgg ctttatctcc aagcccttgc caatgggtgc aattgcaatt tttgcattgg 811561 cggttactgc actaactgga acactatcaa ttgaggatac attaagcgga ttcgggaata 811621 agaccatttg gcttatcgtt atcgcattct ttatttcccg gggatttatc aaaaccggtc 811681 tcggtgcgag aatttcgtat gtattcgttc agaaattcgg aaaaaaaacc cttggacttt 811741 cttattcact gctattcagt gatttaatac tttcacctgc tattccaagt aatacggcgc 811801 gtgcaggagg cattatattt cctattatca gatcattatc cgaaacattc ggatcaagcc 811861 cggcaaatgg aacagagaga aaaatcggtg cattcttatt aaaaaccggt tttcagggga 811921 atctgatcac atctgctatg ttcctgacag cgatggcggc gaacccgctg attgccaagc 811981 tggcccatga tgtcgcaggg gtggacttaa catggacaag ctgggcaatt gccgcgattg 812041 taccgggact tgtaagctta atcatcacgc cgcttgtgat ttacaaactg tatccgccgg 812101 aaatcaaaga aacaccggat gcggcgaaaa tcgcaacaga aaaactgaaa gaaatgggac 812161 cgttcaaaaa atcggagctt tccatggtta tcgtgtttct tttggtgctt gtgctgtgga 812221 tttttggcgg cagcttcaac atcgacgcta ccacaaccgc attgatcggt ttggccgttc 812281 tcttattatc acaagttctg acttgggatg atatcaagaa agaacagggc gcttgggata 812341 cgctcacttg gtttgcggcg cttgtcatgc tcgccaactt cttgaatgaa ttaggcatgg 812401 tgtcttggtt cagtaatgcc atgaaatcat ccgtatcagg gttctcttgg attgtggcat 812461 tcatcatttt aattgttgtg tattattact ctcactattt ctttgcaagt gcgacagccc 812521 acatcagtgc gatgtattca gcatttttgg ctgtcgtcgt ggcagcgggc gcaccgccgc 812581 ttttagcagc gctgagcctc gcgttcatca gcaacctgtt cgggtcaacg actcactacg 812641 gttctggagc ggctccggtc ttcttcggag caggctacat cccgcaaggc aaatggtggt 812701 ccatcggatt tatcctgtcg attgttcata tcatcgtatg gcttgtgatc ggcggattat 812761 ggtggaaagt actaggaata tggtagaaag aaaaaggcag acgcggtctg ccttttttta 812821 ttttcactcc ttcgtaagaa aatggatttt gaaaaatgag aaaattccct gtgaaaaatg 812881 gtatgatcta ggtagaaagg acggctggtg ctgtggtgaa aaagcggttc catttttccc 812941 tgcaaacaaa aataatgggg ctgattgcgg ctctgctggt ctttgtcatt ggtgtgctga 813001 ccattacgtt agccgttcag catacacagg gagaacggag acaggcagag cagctggcgg 813061 ttcaaacggc gagaaccatt tcctatatgc cgccggttaa agagctcatt gagagaaaag 813121 acggacatgc ggctcagacg caagaggtca ttgaacaaat gaaagaacag actggtgcgt 813181 ttgccattta tgttttgaac gaaaaaggag acattcgcag cgcctctgga aaaagcggat 813241 taaagaaact ggagcgcagc agagaaattt tgtttggcgg ttcgcatgtt tctgaaacaa 813301 aagcggatgg acgaagagtg atcagaggga gcgcgccgat tataaaagaa cagaagggat 813361 acagccaagt gatcggcagc gtgtctgttg attttctgca aacggagaca gagcaaagca 813421 tcaaaaagca tttgagaaat ttgagtgtga ttgctgtgct tgtactgctg ctcggattta 813481 ttggcgccgc cgtgctggcg aaaagcatca gaaaggatac gctcgggctt gaaccgcatg 813541 agatcgcggc tctatatcgt gagaggaacg caatgctttt cgcgattcga gaagggatta 813601 ttgccaccaa tcgtgaaggc gtcgtcacca tgatgaacgt atcggcggcc gagatgctga 813661 agctgcccga gcctgtgatc catcttccta tagatgacgt catgccggga gcagggctga 813721 tgtctgtgct tgaaaaagga gaaatgctgc cgaaccagga agtaagcgtc aacgatcaag 813781 tgtttattat caatacgaaa gtgatgaatc aaggcgggca ggcgtatggg attgtcgtca 813841 gcttcaggga gaaaacagag ctgaagaagc tgatcgacac attgacagag gttcgcaaat 813901 attcagagga tctcagggcg cagactcatg aattttcaaa taagctttat gcgattttag 813961 ggctgcttga gcttggggag tatgatgaag ccattgatct gattaaagag gaatatgcga 814021 tacaaaatga acagcatgat cttttattcc ataacatcca ttcgcagcag gtgcaggcca 814081 ttttgttagg gaaaataagc aaggcatcgg aaaagaaggt caagctggtg attgatgaga 814141 acagctcact cgcgcctctt cctgcgcata tcggcttgtc ccatcttatt acgattattg 814201 gcaatttaat tgataacgct ttcgaagctg tagcggagca aagcgtgaag gaagttttgt 814261 tttttatcac ggatatgggc catgacattg tcattgaagt atcagacaca gggcccggtg 814321 tgccgccaga gaaaatagaa gctgtgtttg agagaggcta ttcttcaaag gggatgagga 814381 gaggctacgg tctggccaat gtgaaagact cagtgcgtga actgggcggc tggatcgaac 814441 tggcgaatca aaaaactggc ggggcggtat tcactgtatt tataccgaag gagaaacaaa 814501 gggggaatcc atttgattca catcgcgatt gcggaggatg attttcgagt tgcgcaaatc 814561 catgagagat tgattaaaca gcttgatgga ttcaagatta tcggcaaggc ggctaacgca 814621 aaagagacat tggcgctttt gaaggaacac aaggctgatt tgcttctgct ggatatttat 814681 atgccggacg agcttgggac cgcgttgatt cctgatatac gaagccgatt tcctgaagtg 814741 gacattatga ttatcacagc ggcaacagaa acccgtcatt tgcaggaagc gctaagggcg 814801 ggaattgccc actatttgat caaacccgta acagctgaca agttcaggca ggtgctgctt 814861 cagtataaag aaaaaaggaa gctgctcatg tctcagccgg aggtcagcca atccatgatc 814921 gaccatattt ttgggaacgg tgtgaagaca gctttgccgg cagaggattt gccgactggc 814981 attaattcga ttacactgcg aaaaattaag gaagcgcttc agactgcgtc agaaggattg 815041 acagcggagg aacttgggga aaaaatgggg gcgtcacgaa caactgcccg ccgttatgcc 815101 gagtaccttg tgtcaaagga agaagcaaga gccgagcttg aatacgggat tatcggcagg 815161 ccggagagaa aatattattt ggcggcggat tagatatgaa aaaatctata atcctattga 815221 atattctatt gatctttatg cagggtgata tcaggcaggc ggctgcgccg cgcctgccgg 815281 acgggccgat agaaattgtc gtccctgccg aaccttctgg cggctgggat gtcacagcgc 815341 aggcgatcca atcagttttg aggcagaagc agatcgtgaa ggatgatgtt catatcgtct 815401 ataaatccgg cggcggggga gagaaaggct ggaaatatgt caacaaaagc agcaaacaaa 815461 ccatcagcat gacgtccagc ctaatattga gcaatgatct tctcgggcaa agcaaattaa 815521 aaatgtccga ttttacgccg ctcgccattc tctccaagga atggcagacg gttgcattgc 815581 caaaaggatc agcgttaaca aatggcaagg atgtgctgaa tgagatcaac atgcatcccg 815641 gcaaggtgag aatcggcttt gccccggggt ttggcaatga tgatcagctc tcgttcgtca 815701 gagcggcaga tatgtacggc attgacccgt ttgacattca attctcacag tatgacagca 815761 gcgaacagct cattcaggcg ctgatcagac atgagataga agcggcttcc atgacacttt 815821 ctgaagcgaa accatatgaa cgaaacggcg atatcacgtt agccgctgta acgtctgata 815881 aaagacttcc cggttttcca aatgtaccga cgtggaagga gcagggaatc ccgtttgttt 815941 tttctcattg gagagggatt ttgggcccga aaaatatgtc tgaggaagag atttcttact 816001 gggatcaagc gctaaagaag gtcacctcct cacctgaatg gaagcggaaa ataaacgaac 816061 aggactggga aagcttttat ttaaacagca gggaaacgaa acggttttta gaagagcaat 816121 ctgcttttta tcaaagcatc atgacaggaa attaaaatcc cgacatcccg ggattttttt 816181 catgccgaaa attgatcaaa aagaacaaaa cggttttaaa aaattaaaaa tacaaaaaaa 816241 ccaaattatt tacttgcggt tggttttccc atacgatggc aaaaaggcaa gacaaaaagg 816301 ggagtaaggg agaaaaaaat gtaagcggat tcatttaagg gggaatggat gtgttagcaa 816361 tcttaggctt tctcatgatg cttgtgttta tggcattgat catgacaaaa cggctttctg 816421 ttttaacagc attagttttg acgccgattg tgtttgcgct tatcgccgga tttggattta 816481 ctgaagttgg ggacatgatg atttcgggga ttcagcaagt cgcgccgact gcggtcatga 816541 ttatgtttgc gatcttatat tttggaatta tgattgatac aggcctgttt gatccaatgg 816601 ttggcaaaat tttaagcatg gtcaaaggag accctttaaa aattgttgtc gggacagcgg 816661 ttcttacaat gctcgtcgcc ttggacggag atggctcgac aacgtacatg attacgacaa 816721 gcgccatgct tccgctctat ttgctgctag gcatccggcc aattatcttg gcaggaatcg 816781 cgggagtcgg catgggaatc atgaacacga ttccatgggg aggtgcgacg ccgagggcgg 816841 cgagtgcgct gggggttgat ccagctgagc ttacagggcc gatgattcct gtcattgcaa 816901 gcgggatgct ttgtatggtg gcagttgcgt atgtgcttgg aaaagcggaa cgaaagcgcc 816961 ttggtgtgat tgaactgaaa cagccagcca atgccaatga accggctgct gcggttgaag 817021 atgagtggaa gcggccgaag ctttggtggt tcaatttatt gttaacgctt tctttaatag 817081 gatgtttagt atcgggtaaa gtcagtttaa ccgtactgtt tgtcattgcg ttttgtattg 817141 cgctgattgt gaattatccc aatctcgagc atcagagaca gcgcatcgcg gcgcattcca 817201 gcaacgtgct ggctatcggt tcaatgattt ttgctgcggg ggtgttcacg gggattttga 817261 caggcacgaa aatggttgat gaaatggcga tctcgctcgt gtccatgata ccggaacaaa 817321 tgggcggatt gatcccggcg attgttgcct taacaagcgg cattttcaca tttttgatgc 817381 cgaatgacgc gtatttctac ggggtgctgc cgattttatc agaaacagct gtcgcatacg 817441 gtgtggataa agtggaaatt gccagagcct ctattatcgg ccagccgatt catatgctga 817501 gtccgcttgt gccatccact catttgcttg tcggactcgt cggagtttct attgatgacc 817561 atcaaaaatt cgcattgaaa tgggcggttc tcgcagtgat cgtcatgacg gctatcgctc 817621 tattgatcgg tgcgatctct atttccgtat gataattcag gcgtaatgac acacactaac 817681 ggcatacaac attccggagg tgtcattatg agtgatcctt atatgccgct gacttcagtc 817741 agaagcggag cggggttcga agcggcaaaa ggggtgcacg gcctgactgt gcaaattgcg 817801 aatgtctatt ttattcagct gccttctgaa cctcactcat ttgttttaat tgatgccggc 817861 atgccccaat cagccggcgt gattgtcaat gaagccaaac aaagattcgg tgaagggttt 817921 cagctgaagg cgattatcct cacacacggg cactttgacc atattggggc aatcgaagag 817981 atccttgagc attgggatgt gcctgtttat atccattctc gggaaatgcc ttatgtaaca 818041 ggtaaagagg attatcctcc ggctcgtcct gacagcaaga gcgggctggt cgctaagctg 818101 tcgccgctgt ttccgcggca ctctatcgat atttcctcac atgtccaggc actgccggaa 818161 gacggttcag ttccttttct tgacgagtgg atgtggatcg cgacaccagg acacacgccg 818221 ggccatattt cgttattccg cgatgacggc cgcgtgcttg tggcaggtga tgctgttatt 818281 acagtggaac aggagaaaat ggctgacgtc ttgatacaaa aacaggagct tcacgggccg 818341 ccggcttatt tcacgcctga cacagagacg gccgctgagt ccattctaaa gctggccggt 818401 cttgaaccgg aagcgttatt gaccgggcac ggcataccga tgaccggcaa aaactttcga 818461 agtgacttaa ctgaattggc aaatcggtta tcgtctattt gacacccgca ccacgcgggt 818521 gttttttatt gttttccagg aagttgcaga aaaatcattt gtcttgccgc ttaaaaacga 818581 tacaatgaaa agcatgaagt gatgtgaagg ggagagtttg ttggaagaaa aagaaatact 818641 ctggaacgaa gcgaaagcgt ttattgccgc atgctatcag gaattgggaa aggaggagga 818701 agtgaaagac cgtctcgcgg acattaaaag tgaaattgac ctgaccggaa gctatgtaca 818761 tacgaaggaa gagctggagc acggagcgaa aatggcttgg agaaacagca accgctgcat 818821 cggcagattg ttctggaatt cgctgaatgt tatcgacaga cgagacgtcc ggacgaagga 818881 ggaagtgcgt gatgccctct ttcaccatat tgaaaccgcc accaataacg ggaaaatcag 818941 accgaccatt acgattttcc ctccggaaga gaagggtgaa aagcaagtcg agatctggaa 819001 tcatcagctg atccggtacg ctggatatga gtcagacgga gaaagaatcg gcgacccggc 819061 ttcctgttcc ctgacagcag cctgcgaaga gctcggctgg cgcggagagc gaacggattt 819121 tgacctgctg ccgctcattt ttcgcatgaa aggggacgag cagcctgtct ggtatgagct 819181 gccgcgttca cttgtgattg aggttccaat cacacatccg gacatcgagg cgttttctga 819241 tttggagctg aagtggtacg gcgtgcctat tatttctgat atgaagcttg aggtcggggg 819301 cattcattat aatgccgcgc catttaacgg ctggtatatg ggcacggaga tcggagcgag 819361 aaacctcgca gatgaaaagc ggtacgacaa gctcaaaaaa gtagcgtccg tgatcggcat 819421 cgccgctgat tacaatacgg atttatggaa ggatcaagcg ctagttgaat tgaataaagc 819481 tgtgctgcac tcgtataaaa agcagggtgt cagcatcgtt gaccatcata cagcggcaag 819541 ccagtttaaa cggtttgaag aacaggagga agaagcgggc agaaagctga cgggggactg 819601 gacgtggctg attccgccaa tttcacccgc tgccactcat atcttccacc gctcctatga 819661 taactcaatc gttaagccga actattttta tcaagataag ccttatgagt aaacaataga 819721 aaatcgatga tggccttcaa ggctgcggga ttcagtcaca gagatgtcgg taacctttga 819781 gaaagggctt ccgttcttta cagcctcaac aaacgattgc agggcgtttt ccggaccctc 819841 tgccaaaatc tcgacacgcc cgtcatcacg gtttttgacc cagccggcca gttttcgctt 819901 atcagcttcc atttgaacaa aatagcgaaa gcccacacct tgaacccggc cgtctacaat 819961 gattcggtat tgaagcatgt aaaaaccacc ttttcttttt atgataatca atcattttac 820021 aacctgtaaa ggggatgtgt ttgtatgaaa caagagcgct attcagttct ttctcttaat 820081 ctgggaaaac cgcagacgct tgaatatgac ggaaagaaaa tcgaaaccgg catcatgaag 820141 cggccggcta aatcagccgt catgctgtat cgggagaatt ttgaaggaga cggacaggcg 820201 gacctcgtca accacggcgg acctgataag gctgtctgtg tctacccggc ggagcattat 820261 ccgttttggg aagagttcct ctcaagaccg ctgtcaaatg ccgcatttgg agaaaatctg 820321 acggtcgcgg gcctgactga ggagaatgtt tgcatcgggg atgtgttcag acttgatgaa 820381 gctgttgttc aggtcagcca gccgcgccag ccgtgtgtaa agctggcgaa aaagtttggt 820441 gtaaaagaaa tggtgctgaa ggtccagcaa accggctata cagggtttta ttttcgcgtg 820501 ctggaggagg gcagggtgtc tcccggcgcg aaccttgaat tgctgtccag aggagagaaa 820561 ggcatatccg tccagttcgc gaaccgcatc aactaccatg atgcaaaaaa tctcaccgcc 820621 attgaacgga ttttaagtga ggctgcacta tcggaaagct ggagagcgtc ctttatgaaa 820681 aaaaaggaca ggctgctgcc ggttgaatag aaaaaagccg cgcatatcaa cgtgcgcggc 820741 tttgccatat ttaagattgt tttttctttg attcaagcag gttggcaaga aaataggttt 820801 tatagctttg aagctttctt ccttcatggt gcgtgatccc ctgctttttt agttctgcca 820861 cataccagcc tttactgccg taatgcatgt cagaaaactc ctttccctat ctgatttcga 820921 aacgattggc attgtaacat ctataaaaag atgctgaaaa gagatgcggg gaaaactgag 820981 cctttcgcac tagatgtacg aatgttcttc tgaatgtata tgcggagcaa aagccgaata 821041 tgatttaatg gccggttagt ttgatcatga caacgccaaa tgtcataatg gcgaaaacaa 821101 tgccgatata tgtgagcatc ccgttttttt tcttaacgcc gtaaacggtc ataatgatgc 821161 cttcaatgaa aaaaatgatg ccgaaaataa taaaccacat gcagataaag gctcctttca 821221 cagacataat agtagtgtag catatctgaa agagccgggc tgtgacaata tcaagaaagc 821281 cgggcgcata tcgcccggct catgttttat tgtttatcaa ccaatttgac cagaagctgt 821341 gccaaatgtt ctttctcatc ttcgtctgca acgctccaaa gctcttgcag cagcatttct 821401 tcaccgtttt gcggctcttc atgctttgcg aggtagtctc ccaggatcgc agcgcttttt 821461 acaagcttgc cgtcatccaa tcccagcttt ttgcctcggt tgacttgttt tttcaggtag 821521 cctttaaatt cctcaaagtc ttttaaaatg tcttctttta ttgtgccatg catcgcgttc 821581 atttcgtttt caatttggat tttttcttga tctctgttca ttgcaagacc tcctcgtaca 821641 gaataatgat gctttacctg caattggagg aggttaaacc tgccggaagc ccggaatgtg 821701 ttttacagtt tcgtcaggat aatcggttca tcttttgtga tgacgatcgt gtgttcaact 821761 tgggcaacca tgcttttatc cggcgtcttg aacgtccagc cgtctccagc ttcaacaatc 821821 gtttctgctt tcgttgaaat aaacggttca agcgcgatga ctgtgccatt tttgaacagc 821881 gcattatcaa acggatcata atagttcatg atgtggttcg gcgcttcatg caggcttcgg 821941 ccgattccgt ggccggtcag ggttttgatg acggtaaagc cttgagagcg tgcttcatga 822001 taaacggctc ttccgatctg gttttggcgc ttgcccgctt ttgcctgctg aagccccttt 822061 tgaaaagcgt tttccgcgca ttggcaaagc ttatgaaggc gttcttctcc ttcaccgagc 822121 acaaatgaga tgcctgtgtc ggaatagaag ccgccaaatt cagcggagat gtcgatgttg 822181 acaaggtccc ctgcttttaa aattttggat gtgcttggta tgccgtgagc cacttcatca 822241 tttacgctga tacatgtcac acctggaaaa tcgtattcct tctcaggagc tgaaacggcg 822301 ccgtgctcat caagcacagc ttttccgata aggtcaaggt cttttgtgct catgccgggc 822361 tctgccttcc gcttcatttc ttcacgcgca agcgcgacga ttcttccgat ttttttcagg 822421 ccttctaatt cttgatcgtt tgttacaatc atctgtcatt cccgctttct ttttaaataa 822481 tctagattaa gcttaccaca actgtcttaa aaataggaaa cacacggacc tgggaaaaaa 822541 gaaatacccc cgggaaaatt ggtatagatc actagatatc ttatatggta tatttgaaaa 822601 aaaagggtat gagggggatg ggtatgcttt catttttaca aaaactcggg aagtcattta 822661 tgctcccgat tgcggttctg cctgcggttg gaattatcct tgcgcttggc agagaggatg 822721 tatttaatat cccgtttgtc tatcaggcgg ggacggcggt ttttgatcat ctgccgctta 822781 tttttgcgat cggtattgcc atcggcattt caaaagacag caatggggca gcgggtttat 822841 caggggcgat atcgtatctg atgcttgacg cggcaacaaa gacaattgat aaaacaaata 822901 acatggcggt gtttggggga attattgccg gtttaattgc cggttacacc tataaccgct 822961 tcaaggatac caagctgcct gaatatctcg ggttcttcag tggcagacgg cttgtgccga 823021 ttttaacagc cattattacg atcattttag cgggcatatt cggagtggtc tggccgccga 823081 ttcaatcgtg tatcaactcg tttggagagt ggatgctcgg gctcggcggc atcggggcag 823141 gcatattcgg cctattcaac aggctgttaa ttccgcttgg ccttcaccat gtgctgaaca 823201 atattttctg gttccaattc ggagaatata acggagtgac aggggatttg gcgcgctttt 823261 tcgcgaaaga tccgactgcg ggcacatata tgaccggatt tttcccaatc atgatgttcg 823321 gtcttccggc ggcgtgtctg gctatggttg tgactgcgaa gccgtctaaa cggaaagcga 823381 cggctggaat gatgattgga tttgctttaa cggcgtttat cacagggatt acggagccga 823441 ttgagtttgc atttatgttt ttatctccgc ttttatacgc tgttcacgcg gtcttaaccg 823501 ggttatcttt atttatcgtc aactggctcg gcatccgctc aggcttctct ttttcagccg 823561 gagctatcga ttatgtgctc agctatggaa tcgcggaaaa accgctgctt ctgcttttgg 823621 taggtatatg ctatgcggca gtatacttta tcgtgtttta tgtactgatt aaggctttga 823681 atttaaaaac gcctggacgg gaagacgatg atgtggatga agtgctggat gaaaatactg 823741 ttcaggatgt aaatgaaaac atcatgctga aagggctcgg cggaaaagaa aaccttcaaa 823801 ccattgatca ttgcgccaca aggctgcgac tgactgtgaa ggataccgct ttggtggatg 823861 aagcactgct aaagaaagca ggcgcaaaag gggttgtcaa atcgggcggg caatcggttc 823921 aagtcattat tggcccgaat gtggaatttg cagctgagga attgagggct gctgtcaaat 823981 aaaaaagcgg agagggcaac ctctccgctt tttcttattt atcttcgtta tcctttgacg 824041 tttcggaaga atcttcgtca tgttttgtgt aatcataatc agaaggattc accttcttaa 824101 aacctttcgg ctcgtagaac cgcagcaggt ctccgtttat gattttatcg gacatttcaa 824161 gttccttctt gacgagtgag tcttctgact tgtcgacttc ggattcatcg agttcttttc 824221 cggttttcgt gtcgtaatac ttaccggata ttttcgtgta cttcggtgaa ataaagtctc 824281 cgtttcggaa cggaatcact tcacggtgtt ctttcgataa aatatcagaa ccggacatca 824341 gatagtcctt cgtatccact ccgagcagat gcagaatggt aggagccaca tcaacgtctc 824401 cggcatattt atgaactttc tcgcccttca cgccggcagc gtggataaag agcggcaccc 824461 gttgaagctg ggcgttgtcg taatcagtga tttcatcctt gccaagcact ttcgccatcg 824521 ctttattgtg gttttcagag atgccgtagt ggtctccgta catcacaata atcgatttat 824581 catataaccc gtcttttttc agatcattga agaattgttc aatggactga tcaaggtaat 824641 gggctgactg gaaatagtta tcgacgacag agtcaccaaa gtctccagcc gggaagtctg 824701 tatccccctc atccattccg aatgggaagt ggttggaaag ggtaatgaac ttcgtataga 824761 acggctgcgg caggctttcc agcagcggca ttgattcttt gaagaacggt ttgtctttca 824821 tgccgtagtt tttcgtgttt tcttcgttca tgtcatagta agcagaatca aagaatttat 824881 caatgccttc cgccttgtac atttcgttac ggttccagaa cgtctgcgtg ttcccgtgga 824941 aagtagcaga tgtgtaattc ttagacttca gaatcgccgg aacggattgc agcgtgtttt 825001 gcgctttgtt tacgaaaact gaaccttgag ccagcgggta cagagagttt tccatcataa 825061 attcagcatc agatgtttta ccttgtcccg tttggtggaa aaagttatca aagtagaacg 825121 tttcgttatc atgtgccagt ttatttaaga atggtgtcac ttctttgccg tcaattttat 825181 agtcgatgat aaatgactgc aaagattcaa gtgaaacgta aatgacgttt tttccttccg 825241 ctttgccgaa atacacgtta ttcggcacat cgtaattggc tttcatgtag ttttctactt 825301 ccgttacgtc gctggaatcg gcaagcgcgc gctggctgtt ggacttgata ttctgtacag 825361 cgtcataaat cgtgaaattg tatgttccca agtatttcac aagatagttc cggtcgaatg 825421 atcttgtcag caattcagga cggtctgatt ccgcaactgc caggttgatc aagaacacaa 825481 gaattgaaga cgcaaaaata attcggaacg attttttgct tgacgtttcg gcaggcttgt 825541 ttactttgat cgccaagatg atcaggatga tcgtatcgat aaagtaaaag gcgtcagtcg 825601 gtctcatcag cgaaaatgcg ctgtcaccga gttggccgcc gtttgtttta gcctgcataa 825661 tgaccggaat tgtaataaaa tcattgaaaa atctgtagta cacaatgttg gcgtacagta 825721 aaaaagacat taaaaaatga atcactataa tggctgtctg ctgtaatttt ttcttgaaca 825781 agagtccaaa gccaagaaag aacaagcttg agctaagagg attcacaaaa agcaatattt 825841 tttgtatcgt gttgtctatt cctaagttga aattcaggac ataaccgaca tacgttttga 825901 tccataacag gacgaccgca attaagaaga aggccagtcc tctttctttt ataaatgttt 825961 tcattgttac actccttttt tccgatccag ttcgagcgaa acgatagaaa aaacgaacgt 826021 atccaatata acacgaatca gcagattaga aaagtgaaaa tcgtatgagg gagaaagtgg 826081 cgaaaaacgc cgtcgaatca acgtttcgct ttgatattac caaatgtaaa acaaggtatc 826141 tttctagaaa taaaggaata aaatggtaca ttgagaattg tatgataaaa tataaggtat 826201 agataaaaag aggtgaaatg atggattttt cccatattgt gtctgaagat aaaattaagc 826261 gcgccatcaa agacggggac tttcaaaacc tcccgggaat ggggaagccg ctgccgaagg 826321 atgacgcggc acacttgccg gaatcgctgc gcatgggcta tcgtattttg aaaaacgcgg 826381 gaatggcaga ggacgagggc gcgctcaaaa aagagcttat gaccatcgac catttaatcg 826441 aaaagtgcta tgacgaaaaa gaacgcgagc aattaatcag aaaaaaatct gaaaagcaat 826501 tgctgcttga taagcttgtc gacaaaaaag gcatgttttc aaagccagca tccgcttttt 826561 ataagaataa agtatatgac cggcttggac gaaacagacc ttcttccagc tgatttgtct 826621 tgtctgcagg atggcgattg ataaaagcca tcctttttat gttccaagtt ctatgtcaaa 826681 aggtttatgt ttttccatct atgggaaatg attcataaac gaaaaaaggg tgatgggatg 826741 gaacgactat tagtatggat agagcatata tctgattggc tgtggggtcc gccgctaatc 826801 atcctgctga cggggacggg cttgtatttc actattttgc tgaaaggttt tcaatttcgc 826861 tatcctttat acattttcaa acagacaatc ggcagtgtag gaaaaaagcc gaagggagaa 826921 ggcacagtca caccgcttca ggcattgacc tcagccctca gttcaacgat cggtgcagcg 826981 aacattgtcg gtgtgcccgc cgctattatg tttgggggac caggagcggt tttttggatg 827041 tggcttattg ccttatttgc catggcgatt aagttttctg aaagtgttct tgctgttcat 827101 tacagagaaa aaaatgagca gggtgaatac gtcgggggac cgatgtatta cataacaaaa 827161 gggctgcgca tgaaatggct cggcgtattc ttctctgttg cgctgattgt ggagctgatt 827221 cccagcatta tggttcaggg aaattcggtt tcagtctcgc ttgccgagac gttttctttc 827281 aataaaatat acgcaggaat cggaattgca tttttgattg ggttagtggt gataggaggg 827341 gtaaagcgga tcggaaaagt aacagagttt gtcgtgcctc ttatggcagg ggcatacgca 827401 ggtgccggtc tcctgattgt tctcatgaat ctatcatcag tgccggcgtt tttctctctc 827461 gttttttcaa atgcgtttac ctcttcttca gcagttggag ggttcgcagg tgctgcgttg 827521 gcggaaaccg ttcgctgggg atttgcccgc gggctgtatt ctaatgaagc cgggatggga 827581 acagccccga ttgcacatgc ggcagcaatg actgatcatc ctgtgcggca agggttttgg 827641 tctgtgatcg gcattgtcat tgacacctta atcatctgta cgactaccgc ttttatcgtc 827701 cttgcatccg gtgtatggac agggaagaac gcctcaaatg acccggcagc actgacaacg 827761 gccgcatttc agcactattt cggttctgga ggaggatact tcgtttcggt ttccctggtc 827821 ttctttgtcg tatcaaccat tatggttgtc attttttacg gcgtaaagca agctgaattt 827881 ctgttcgggc ggctggcagg acatgtgatt aaattcgttt atttagcggc tattatcata 827941 ggtgccgcag gcggagcaaa agccatttgg ggcgtattgg acttagcatt ggtttttatt 828001 gttgtcccga atgtgattgc gctcttgtta ttgagcagaa aggtaaaagc gctgtacacc 828061 gaattcttta catctgaaca gtactacctg aaagatataa gaaaaacgaa acaaaagcct 828121 gtttatccaa caaaagaagc taaaaattcc tagtgttttg cttttgcgcc gaacaatgct 828181 ttgcttttta tgatcaaata aatgagtaaa ggcagcaaaa gagaaatcac tacattaatg 828241 attggtttga ttctgttaaa gtcgattagc tgatttgtat ttaaaaaaaa ccaaaagccg 828301 catacgactg agaacatgcc ggttggtgta tacatggctt tcgggtcgat ttttgagtgt 828361 aaaaacgaaa ggccgtatac cacgatatat agggaacctg ctatcttcac cataatgacc 828421 ggaatccaaa aagccgcgat gatcaggtct gagcgatcca gaaaatccgt aatgcggatc 828481 tgcctgatga ccatataagc aggatcaaag aaagtagatg tcaggttggg accaaagaca 828541 gaaattgaag aaaataacat cacggccagc aataaagcgc ccagcagtat cgcgaaaatg 828601 gtgtatttta gcgggacgct ccggtttgag aagagaagcg gaaggataat caattccccc 828661 attgtcccaa acgcgtaata gcctgattga aggtatggga ttagaccttc aaaaacaggt 828721 gtcaagtttt gaagctcaat ttgtgtggcc agcgtaaatg gaaggaacaa gaccaggatg 828781 ccgaatggaa ataggaatat ctgcgccatt ctggtcaatg tttcttttcc ctctctggca 828841 atacagatcg ccacaaagat aataacaccg ccaagaacag ccattggtgt tctcgggaga 828901 aataaaatgt taatcaaatt gatgaaaaaa cgtatatcat gagcattgat taacaggaaa 828961 tacaaagaaa acagtaaaat gataatccgg cctgcgattg gtgaggaatc gctcagcagc 829021 tcatagatat ttttatcctg atgctttttc atcagcctat gcatgagcca gagtgccgga 829081 atcacgatga caacgccgag gatgtagctg tgccaggcat tttgttttgc tgattcgatc 829141 atgagaatcg gagcatgctt taatccgact gctaacgtat acagagctcc gaaaaataat 829201 ccttggtatg cagaggtctt gtccataaag cacatccttt ctgtcatgtt caaaacggaa 829261 tatatttaaa caggtgcccc agccgcggaa gcaggggatt cactctcata taaatccata 829321 gaaaagcact tcctgcaatt agcaggctga aggcccattt tgttagattg ttagcggaac 829381 gaaaattctt ccattcatat gcgtatatgg caatgcacac aatcaatgtc tgtacgatat 829441 agctgatcat gctgacgcac ctccattaat ggctgatcgt tttgtatagg acaccgccct 829501 gctcaatcgt cacaattggg acgacgtgaa cctccatatc cttatatacc tcttcccatt 829561 cctttttcag cagattcttc gtggttgccg tgcttctgat ggtcctgtct tgaaagccgg 829621 ccgggtccgc ctttagcttt tgcaaacgat gaacggtgct gatcacgtcc ttctttatgg 829681 ttctgtttaa tgctttttga atgatgtaat actggtcatt ttctctcgtc tcataggttg 829741 attggttttc cataataatt cctttggctc tgatctcgat tgtcattgac agctttccgt 829801 ttttttcagc ggcatgaaag gatgcattgg acttttgaag ctgaatggat gcttgcccca 829861 tttgattcgg caggtctact atgaattctg gctggcgggc ttgattcagc aacatcaggg 829921 ctgctgtcat gtgttcatct ttgaaaatat ccatcaatct gtccttttta aagatcgcaa 829981 gcccgtcaat tttcaaatta gatttgcctt tccctccagg ttttgtttta gatgcagaga 830041 tgaccggtgc atacggatca ctgcctattt ctactagatc agacatgaat ctgcttaaga 830101 aaacggggcg gctcgttgcg ataatggcca gctcccgaat catttccgcc ggaaactgtt 830161 caagctgaac atcggtattt aaaatgtccc gcgcttctcc ccggctgact aaaatgagcg 830221 ccgttaatct gttctgcgga tttcgcgtta aaatatcaaa gactggggca acgccgtctc 830281 tcgccatatc ctctccaata atgactgtac gtctgtggga cgtattgatt gtccgtgaca 830341 aggaggtttg cagcttgttg ttcgcttctc tgatcgtagt gccggaagct gaatcaacat 830401 accatgtttt tgaaccggca gttccgccgc cgccccctgt ttgtccgcct aattggccga 830461 ccaagggaat ctgcatggcc actcgatact gatctttttt cttatcaatg gctgagctga 830521 caacaaatgc aatgtcattg atttctgtcc ggtcccagca ccccgttaga aggatacaaa 830581 tgagaagcgg caaaacacac ttatatattg ttttcttcat cttttgggtc ctctcttttc 830641 gctcccttct gtccgttgcc gcgcgaatac gtgcccggcc ttctggtcat cgtccaccaa 830701 ggcgccctga caaaaatatc ttttacttca tctcgtttaa acggagaaat cccggataaa 830761 taaggaatgc cgaaagattg cagcttgcat aaatgaagca ctaagataat cgtgccgagc 830821 ataatgccga atatcccaaa aatactcgcc aaaaacataa gcgggaaacg aagcatcctg 830881 atggagatag ctaagttaaa ccgcggaatt gtaaatgacg cgatccctgt taacgatacg 830941 atgatcacca tgggggcaga cacaattccc gcttcaacag cggctgtccc aatgactagg 831001 gccccgagaa tactgacggt ctggccgatg gttttcggca ggcgcactcc cgcctcacgg 831061 agagcctcaa aagaaatttc cataatcaat gcttctatga tggcggggaa aggaatcggt 831121 tcacgcgcag aggccacact gaacattaag tttgtcggca ttaagtcctg gtggtatgta 831181 ataacggcaa cataaatagc cggcaaatat aaagcaacga ataaaaacat atagcgaagc 831241 cagcggatta agttagacat caaataacgc tcatagtaat cttcactggc ctgcataagc 831301 tgccaaaacg taatcgggcc tgttaagaca aagggcgtat tatctgtgaa aatggcaaat 831361 cggccttcga gaagctgggc ggcgacggtg tccggccttt ctgtgtattg cagctggggg 831421 aatggcgagt acgtgtcgtc ttcgataaat tcttcaatat atccgctttc taagacagca 831481 tcaatcttta tctttttgat tctttttttt gctttgtcaa taacctttgg atcggcaagc 831541 ccgtcaatat aggccaagac aacatcggtt ttggttttcg tgccgatttt aaaagagatc 831601 attttaagct gaaacgtttt gacgcgaaag cgcacaagag cggtattgac cctgaggctt 831661 tcagtgaagc cctctcttga ccctctgatg gtcgattctg ttatcggctc ttcaatgctt 831721 cttctttgtc cgccttttat atttaagatc aggccttttg agtgcccgtc ggcaaataaa 831781 accgcgttcc cctcaatgat ggatgcagcc actttgctca tactcgtttc taatgcaaca 831841 cttgaaattg atagagtatt ttgcagcgcc tcttcatgtt catctatttg atccgtcaaa 831901 tgcattaaga aagggcggag ggcgtgatcc tgaatatgtt cagattttac aattccttcg 831961 atataaacaa taaatccgca cagcccgttt ccaaagtcaa attgtctaaa tacgatgtct 832021 gagcagcctt ctgttaataa ggtcagattt tcgaggtttt ccttcaaatt gggagagatc 832081 ggtctgtcct gattgtcttc aagctctttg atgagctgaa gcgctttgtc gcgtttattc 832141 atagaggctc accctgcttt ttaatgtcat attcaataag tgcttgtgac ttttagggta 832201 accttgtctg tttcatatat tccagactag gatgaaagcg ctataaaaaa gtgttgacta 832261 cctgtatata caggaataca atatgattat aagttgtata tacaagttat aaaaacggat 832321 acggaggggt tggcatgggg gaactgaaca aatcggcacg tcagattgtc gaagcagtcg 832381 gcggtgctga aaatattgca gcggcaactc attgtgttac acgtttgcgt tttgctttaa 832441 tagatgaaag caaggttgac caagagatgc ttgatcaaat tgatgtggta aagggatcat 832501 tctcgacaaa cggacagttt caggtcgtaa tcggccaggg aactgtcaat aaagtatatg 832561 ctgaactggt taaggaaacg gggattggcg agtcaacaaa ggatgaagtg aagaaggcct 832621 cagaaaaaaa tatgaatcct ttgcagcgtg ctgtgaaaac gcttgcagat atttttattc 832681 caatattgcc tgcgattgtc acggcgggtc ttttaatggg gatcaataac attttaacgg 832741 cggaaggcat tttcttcagc acaaaatcga ttgtgcaggt ttatccgcag tgggcggatc 832801 ttgctaatat gattaacctg attgcaggca cggcctttac gtttttgcct gcgttaatcg 832861 gatggtctgc cgtcaagcgg ttcggcggca atccgcttct cggcattgtg ctcggggtta 832921 tgctcgtgca tcctgatttg ctgaatgcgt ggggatatgg cgcggcagaa caaagcggag 832981 agatcccggt atggaatcta ttcggcctag aggtgcagaa agtcggctat cagggccagg 833041 tgctcccaat tttgcttgct tcttatatgc tggcgaagat tgaggtattt ttaacaaaac 833101 gcacacctga gggcatacag ctgctcgttg tcgcaccaat tacgcttctc ttaacaggat 833161 ttgcctcttt tatcattatc ggcccgatta catttgcgat cggtaatgta ctgacttcag 833221 ggcttatctc ggtgtttggt tcttttgccg cactgggcgg tctgttatat ggcggtttct 833281 actcagcgct cgtgattacc ggtatgcatc acacgtttct tgcagtcgac ctgcagctca 833341 tcggttcaaa gctcggcggc acctttttat ggccgatgct ggcgctttct aatatcgcac 833401 aaggttcggc ggctctggcc atgatgttta tcgtgaagga tgagaaacaa aaaggcctct 833461 ccctcacatc agggatttct gcttatcttg gcattacaga gcctgccatc tttggggtga 833521 atctgcgata cagattcccg tttatcattg caatggtcag ctctggcctg gccggaatgt 833581 atatttcttc tcaaggtgtg ctggcaagct ccgtcggtgt cggcggcgtg ccggggattt 833641 tctcaatcat gagccagtac tggggcgcgt ttgcaatcgg gatggctatt gtattgatcg 833701 tgccgtttgc cggaacatac gcgtatgcga gattcaaaca taaataacaa gtggggagcg 833761 ggacgtgttg aacgttccct tttcccgttt tcaatttaaa tatggtggtg gaaacagatg 833821 aaaacagaac aaacgccatg gtggaaaaaa gctgtggttt atcaaattta tccgaaaagc 833881 tttaacgata cgacaggaaa tggtgttggc gatctgaacg gcattattga aaagctggat 833941 tacttaaaaa cgctacaggt ggatgtgctt tggctgacgc cgatttatga ttctccccag 834001 catgataatg ggtacgatat tcgtgattat tactcgattt atcctgaata cggaacgatg 834061 gaggattttg agcggctagt gtccgaagca cataaaagag acctgaaagt cgtcatggat 834121 cttgttgtca atcatacgtc aacagagcac aaatggtttc gcgaggcgat ctcttcaata 834181 gacagcccgt accgtgattt ttatatatgg aaaaaaccgc aggaaaacgg ttctgttccg 834241 acgaactggg aatcgaaatt cggcggctcg gcatgggagc ttgacgaagc atcgggccaa 834301 tactatttgc atctgtttga tgtgacgcag gctgatttga attgggaaaa tgaagaggtc 834361 agaaagcatg tctatgacat gatgcatttt tggtttgaaa agggaataga cggctttagg 834421 cttgatgtca tcaacctgat ttctaaagat cagcgctttc cgaatgcgga ggaaggcgac 834481 ggccgctctt tttacactga cgggccgcgg gtgcacgaat ttctgcatga aatgaacgaa 834541 aaggtgtttt cacattacga cagcatgacg gtcggtgaga tgtcttcaac aaccgtagac 834601 cactgcatcc ggtatacgaa tcctgacaat aaagaacttg atatgacatt cagcttccat 834661 catctcaagg ttgactatcc taacggcgaa aaatgggcct tggcgccgtt tgattttttg 834721 aagctgaagg agatcctatc tgactggcaa acggggatgc acgcaggagg gggatggaac 834781 gctctgttct ggtgcaatca tgatcagccg cgcgtcgtat caagatatgg agatgatggc 834841 gcatataggg tgaaatcggc gaaaatgctt gctacggcca ttcatatgat gcagggcacg 834901 ccttatattt atcagggcga ggagctgggg atgacgaatc cgaagttcac tgacataagc 834961 tcctatcggg atgtcgaatc gctgaacatg tatcacgcct ttaaggaaaa aggaatggct 835021 gatcaagata ttacagccat tttacaggcg aaatcccgtg acaattccag aacccccgtt 835081 cagtgggatg ctacggaaaa tggtggtttt acaacgggca caccatggat accggttgca 835141 ggaaattacc gggaaatcaa tgctgaagcg gcgctgaggg atcagaattc ggtgttttac 835201 cattatcaaa aattgattca gattcgcaaa atgtatgaca ttgtgacaga gggtacgtat 835261 gagataattg caaaggatga cccgaacatt tttgcgtatc tcagacacgg cagcaatgaa 835321 aagctgctcg tgatcaataa tttttacggg acagaggcgg cctttacact gccggactct 835381 ttagcgcctg acgaatggaa ggcagaggtg ctgttgacga acgatgaagc aagggaaggg 835441 cttcagaaca tgacgcttcg cccatatgag tccattgttt atcgtttaac gaaaccgtgt 835501 taaactaagc tgggtggtcc ataatgaagg tgaataaatt catcacaatt tataaagaca 835561 tcgcacagca aattgaaggc ggccgatgga aagcggagga gattcttccg tctgaacatg 835621 agttgaccgc acagtacggt acatcaagag aaacggtccg aaaggcgctt catatgctcg 835681 cgcaaaacgg ttatatccag aaaatcaggg gaaaaggctc cgtcgtgctc aatcgtgaaa 835741 aaatgcagtt tcccgtttcg ggccttgtca gcttcaagga gctcgcgcaa acgcttggca 835801 aagaaacgaa aacaactgta cacaaattcg ggctggagcc tccgtcagag ctgatccaaa 835861 aacagctccg ggccaatctg gatgacgaca tctgggaagt catcaggtct agaaagattg 835921 acggggaaca tgtgattttg gacaaggatt actttttcag aaagcatgtc cctcacctga 835981 cgaaagaaat ttgtgaaaac tccatatatg aatatataga aggagagctc ggtctttcga 836041 tcagttacgc ccaaaaagaa attgtagccg agccgtgtac ggacgaggac agagagctgc 836101 tcgatttacg cggctatgac catatggtcg tggtgagaaa ctacgtcttt ttggaggata 836161 ccagtttgtt tcaatatacg gaaagcagac accgtctcga caaattccga tttgttgatt 836221 ttgcgcggcg ggggaaatga gagaggcgcc tgcctgcggc agcgcgcttt tttgtttggt 836281 atcaaaattg atactatcca acaaaaatgt gcgtactttt actttttatc ataatggcta 836341 caatagagat gagagtaatc taaaggagag gtgttttaca tggcagatct aaagacacaa 836401 attctggatg catacaattt caggcatgcg actaaggaat ttgacccgaa taaaaaagtg 836461 tcagacagcg attttgaatt tattttagaa acaggaagac tgtctccgag ctcactcggc 836521 cttgagcctt ggaaatttgt cgtcgtccaa aatccggaat tccgcgagaa gcttcgtgaa 836581 tacacatggg gcgcgcaaaa gcagctgccg accgcaagcc atttcgtcct gattcttgcg 836641 cgtacagcga aggatatcaa atataatgcg gactacatca aacgtcattt aaaagaagta 836701 aaacaaatgc ctcaagacgt gtacgaaggc tatttaagca aaacagaaga attccagaaa 836761 aacgatttgc atttgcttga aagtgacaga acattgtttg actgggcatc aaaacaaacc 836821 tatatcgcgc ttggcaacat gatgactgcc gctgcgcaaa tcggtgttga ttcctgcccg 836881 atcgaaggct tccagtacga tcacattcac cgtattcttg aagaagaagg ccttctggaa 836941 aacggaagct tcgatatttc tgtgatggtg gcattcggct accgagtgag agaccctcgt 837001 ccgaaaacaa gatctgctgt tgaagatgtt gtgaagtggg tttaaaagaa gaaagctgct 837061 cgcatagcga gcagctcttt tttatgcctg attcgctcta ttctgttttc tcctctgatg 837121 taagtacatt gccgttccga gtgcgctgat cagaaatccg gccaacagga tcgagtacat 837181 ggatgtggct gtgtccggaa gcaggccgcc agccggaccg tctgttcctg atccgcccga 837241 accgtttcca ccagagccgt tagtcggttg agtgccggga ggcgtatcat ttcctccgtt 837301 tccgtcagtt ggctgttttc cgcctggttt gtcggagcct ccgccatgat tgccgtcatc 837361 accgcctgtc ggttgatctg acgggaatgc cggcggtttg ttgtttgaac cggaatttaa 837421 gatcgtgtat tcgctgaagt ggtttgtata tcctgtcacc atatcatcat cgactgatcc 837481 gtgacctgtc tttgtgaaag ctttcttttt tctatcgacg tgataaatgg cagggttatg 837541 ggcttcttca atatcaaaca tgcgaagcga aagctgtacg ggctccttga atgattttat 837601 ttcttttcct ttttgcttca ctgtaaagtc atatacatct gacagtgaca catccaattc 837661 tcccgtagac ttgattccga ttgcagtgtc tgcggtttta aggttcgcca ttggcatctt 837721 catgctgtac cagtagttga acatcgtcaa tgaaggatct gactctcttt ctttcaaaag 837781 tttgacctga tcttttttca ctttaagatt gataggcttc tcttgagatc cttcatgtat 837841 tccataatag acaaatggcg tgttggcatt tttagcataa atcgcaaatt tgtcttcatc 837901 aagtgtccag ctgccgtcct tctgctttgt cggcaggaat acttctttga ttcgtccttc 837961 aactttagga gagaccttgt ttcctagttt tttcagctgt tcggtgaaaa tctcataatc 838021 aacgtagcca aggtcttcac catgggaggc ttctgtaaag acagaatatc cgtctcctcc 838081 ggcaccgaca aaattatttg ttgccacgcg gtaggtatca tccgtattta tagcaacttt 838141 gtctccgtta ggcgattcaa ttttcacttc taacacacgg tgtccaggtt tgttgtttaa 838201 tgtaaaggta tattcgattc cggccacctg agggaaagcg ccgccgccat tttccacatt 838261 gcttaggcct tgttcaaggg cttctttaat ttgttttccg gttaaatcgg ccacgtaaag 838321 cgtattgccg aacggcatca cgttgagcac ctcgccgagt gtgatatcac ctttgtcaat 838381 gcctgctctg atgccgccgc catttgttat cgctattctg gcgccggctg cttctttcgc 838441 ttttgccagc ataccgtccg cgatgaagtt tccgagattc gtttctttcg tgcgcacatg 838501 ctcacgctgg ccgtcaagcg ccacatccgt gtagccgact ttttcatttt tcacgtcctc 838561 taattcattt ttgaactgat cgagctcttg ttttgcttct gggttttctt ctgtatgttc 838621 atcaattggc agcacgctca gatttgattt atctgtttgc acaacgcctt tttcatcaaa 838681 cgcgacatca acgcgcccca agaattggcc gtattctttt gcctgcgcca cgatcgtcgg 838741 ttcttcgttg ttcacgacct ccattttgtc tacgagggtg tgagtgtgtc cgccgatgat 838801 caaatcaatg ccttttactt ttttggctag ctcaagatcc cggttatgtc cgatgtgggt 838861 taaagcaata attttattta ccttttcttc ttcttgaatc gctttgacgg tgttttgtgc 838921 tgtttcaaag gcatcattga atacgatgct tttgcccggg cttgatgtgg tggctgtatc 838981 ttctgttgtc aggccgaata cggcgacttt ctccccgtca acgtctaaca gaatgtaagg 839041 gtgaatgccg gcctctttct tttcacctgc cgtaaaggtt tgcggctttt tgacaaatga 839101 tttcagcttg ggctcatttg acacatctac gtttgcactg acaatcggaa attccggcgc 839161 ttcaaagtga tagcggttcg ccggatcaac ggttgcgctg tttccgctta gaaaatcaga 839221 aagcaccgtc gggcctttgt caaattcatg gtttccgaag gtcatggcgt catagcccat 839281 catgttcatc attttcagat cggccaaacc gttccattta gtaaaataca gatcgccgga 839341 aaacacatct cccgcatcaa ggagaatatt gtgatttgtt tcgctgcgta cttcgttgat 839401 tttcgtcatt cgtctcgctg catcatcgag atgggcgtgc gtatcattgg tgtgcatgac 839461 ggtcagatcc cacagtccgt ctttaggagg atctggattt gaatcatcat cgaattgcag 839521 cttatacaca ccatagcctt cattcgcaga cttgcctaca taagcgacat cgtctgcttt 839581 atcggcaaat ggcttggcca aaagcgagga ttcaaacgtc agattcgtgc cggaaacagg 839641 cgcgattgac cagttgttgt ctgcttttgg attgactgtt ttttgttcaa taatgtaatc 839701 catcagcacc tgcctatttt caactgcaga gccgtggaca attttatcgc tcgtcagatg 839761 agggaacccg ccgcctccgg acgcacgata gttattggtg actacgagaa attcctggct 839821 tgggctgatc ggcttgcctt cataggaaag attgatgata cgggatgaat ccgcattgat 839881 cacttttccg ttctcattgt atttagccgg ttttgtcaca tcgacctgat atgtgacacc 839941 gtcaatcacg tcaaaattat aggagcggaa attctcgttc agcaaggcct ggtcgccgcc 840001 tttagctgga tcaatttgat tgaattggcc tgctgacatc tccagccagt ccttgacctc 840061 gctgcctgtc agcttgacga tttgaacagt attatcgtaa agatacaagt caccgacatt 840121 tttaatcgca agatctccgg ctggaatgtt tgtatagtaa ttggctccgt ttctgccgcc 840181 tgctttaaac ggcgctccag cggataaaat cggcaggttc ttgtactcgg tatccttcat 840241 ttctttttca gcgtaccact tttgcgcgtc agtcacgatc tgaatggaag gatcatcttt 840301 gacctgtgca aagaagctgt taatatctgc ttcggttttg ccgactggct ttcggacata 840361 ctccagtgtg ttttggtgtg tttgctgaat ggtgtttgta acggtttcgt ttcttgatgt 840421 gacgttgcca gcaatagatt caatacttcc tttggaatct gctaccttcc atgagccgtc 840481 cgccttttca agcttgaggt caatcacgcc taaatatttg ccccagctgc ttggcatgac 840541 gacaggaatg ccgttaattg ttcccttttc cacattgaac tgagcaacac ccgcatactc 840601 ggcggaagga aagagtccgt gctgatggcc cgagataatc gcgtcaatgc ctttcgtttt 840661 ggtggcaagg tcaaacacgg cgttttctgc gcctgatgat tgcgcctgct tttcaatgcc 840721 ggtgtgggcg agggcaataa tgacatctgc gccttccgcc ttcattttcg ggatcgtttc 840781 attggcggat tctacgatat cctgcacctg aacttgcccc tcgagattct ttttgtccca 840841 tgtcatgatt tgcggcggga caaagcctat gtagccgact tttactttct gctcattacc 840901 gttttcatca atgagggttt tttcattaat cacatacggc gtataacggt tttcgccgct 840961 agttgttttg acgttggcat ttacaatcgg gaaatcggct cctttgattg tgccgtcgag 841021 aaagtcgagc ccgtagttga attcatgatt gccaagcgtt ccggcgtcgt atttcagcgc 841081 attcatgacg ctgataatcg gatgggtttt cgtgccggag ataatgtcgt ctttttgata 841141 tttcaccgcg tattcaccca gcggattccc ttgaatcaag tcgccgttat ccacaagcag 841201 ggtgttaggg ttttgctcgc ggtgcttttg gatcaattgc gctgttctcg ccagaccgaa 841261 atccgccgtt tctttgtcgc tgtagtaatc gtaatccatc atgttggcat gaatatcagt 841321 cgtagccaaa atactcagat gcacctgagg agccgcgctt tcttctgcat gaatgggtgg 841381 tgttgggagg attaggctaa gtatcataat tgggggcaaa agaatacgga gaatgttttc 841441 gacgtgtgtt cgtcttttct gtattctcac cagttctcca cctttcaacg aaatttgtgt 841501 tacagctcct attgtaagaa tattttgtaa ctatttgtag gtgtttcttt atgattattg 841561 taaaagggag aaaaatgagt attatgtagc agtatcaaac gacaaatact gggcatttat 841621 gcttatcgtt tgtcacaatc gcggaatgtt tattttagtg tggctggggt agagtgtttt 841681 atgtagacat ataaagcggg aggttatgaa tcatggggaa aaaaattgca gttgttttaa 841741 catattattt tgaggacagc gagtacactg agcctgcgaa agcctttaaa gaagcgggac 841801 atgaactgac tgtcatcgaa aaagaaaaag gaaaaacagt aaaaggcaag cagggaacag 841861 cggaagtgac ggttgacgcg tccattgacg acgtaaattc ttcagacttt gatgcgcttt 841921 tgattcctgg aggattttca ccagaccagc ttcgcgctga cgatcgtttc gtccaattta 841981 caaaagcgtt tatgactgac aaaaagccgg tatttgccat ttgccacggc ccgcagcttt 842041 taatcaatgc gaaagcgctc gacggccgaa aagcgacggg ctatacgtcc attcgtgttg 842101 acatggaaaa cgccggtgcc gacgttgtgg acaaggaagt ggttgtttgc caggatcaat 842161 tggtcactag ccgcacaccg gacgatatac cggcatttaa ccgcgagtca ttggcattgc 842221 ttgagaaata agaaaaaacg gacgctcttg ggcgtccgtt tttttgttgc ttaggcttga 842281 gcacctgtca gtttcttgta cctgtaatac aagaaagcag ctgcagccgt tccgatgacc 842341 gcaatgccga agtcgaatat gaaaatatgg gcgatgcccc ccgcttttgc gataagccct 842401 gttgcaatcg gcagcagaat cgatgcaaga cttgaagcag tcgctacaat tccggtaacg 842461 gttccttttc gcttccagaa aagctctgtc attaacgtaa tggtaatttg aaacacaccc 842521 gcagttgaaa agcctaagaa aaaggcagtg atgtccagca caactgggat atgaacggtc 842581 agcatgactg cgagcgtaca taaagtaata ataggatata agagcgttat gaagacaggt 842641 ttgacccatc tattcagcaa aacggctaat aataaaacag atgccagaga tcctatacta 842701 taatagctca gcaattgtac agatgctgat tcagctaaac cggctgcctt ttgcgcgtag 842761 ctcgggagcc agatttgaga aaccgtaaat aaagccgtgg atgtaaaacc gatgataatc 842821 agtgcggtgc cttccttctg aaaaacgggt tcagacaaga aaacgggaga ttcctgttgg 842881 ccgctattag ttggtttctt atgtttttta ggaaacgaaa gcgttgataa ataaataata 842941 ttcaggagat agaccgctgc cggcagataa aaagcaaatc cgtaaaacat gctgtggtct 843001 gctaaaaatg tgatcaaaag cggcaaaagt gcggccccca cagacataaa ggctttaacc 843061 aagacatttg ccgaaccgga agcagacgga aagagctcgg ttagggccgg atatgttccg 843121 gcatccatgg ctgaattagc gactccggct aataaagcga acacaaacgc cagctcatag 843181 ctcggtgata aaggaatacc gactaaaaag acggccataa ttcccgcaga agcgacaaca 843241 agcggctttc tgccgatttt atctgataga acgccggaaa tgccgtatgt cagcagtttg 843301 ccaaacccga tagcggcaat gacataactg atgccggtcg gatcggtatt ccactgtttt 843361 gttaatgaag acatattgga tgcgagaatg atgttgacca tccccagaaa gaagtagttg 843421 atatacattc cggatgctgt tttgatagat gtcgtttgca tgcttgtact ccttcaaatc 843481 ttattcgaac actttgctgt tttggtttgg ggaaatgata aaaaagactc gccgagtttc 843541 cggccagtct ccattattta cgaagcgagg ctaattcttg agcaatcgcc tgcatttcac 843601 ttgggctgaa tgattctttt ttcatcacca ttctgtgaag gtacgtgagg tcttcaatct 843661 tctcatcact gaaatcctcc gctttgatta cgccgacgtt cagcatgttc agcttttggg 843721 aaatctcttc aatcatttga gttaatgttt ctgtatttgg gctggacaaa gggttccatc 843781 ctttctatgc gcaatatagg tatgttttat tctaacagaa ttccatcaga aaaaaaccct 843841 attctaaaag caggctgttc attccaaaaa agtgaagaca tcagttgaaa agaaaatgaa 843901 catcctacta agatattcat gaaggtttct ttttagagaa ataggggcaa agaataggga 843961 ggttgcacat catgataagc gtgttatttg tttgtttagg taacatttgc cggtctccga 844021 tggcggaagc gatttttagg gacctggcag ccaaaaaagg attagagggg aaaatcaagg 844081 cggactcagc cggtattggc ggctggcaca tcggcaaccc cccgcatgag ggaacgcagg 844141 agatattgcg cagagaagga atcagctttg atggcatgct ggcgcgtcaa gtcagcgaac 844201 aggatctgga cgattttgat tacatcattg caatggatgc agaaaatatc ggaagtctca 844261 gaagcatggc gggttttaaa aacacctcgc atatcaaaag gctcttggac tatgttgaag 844321 attcagatct ggctgacgta cccgatcctt actacacagg gaactttgaa gaggtctgcc 844381 aattaatcaa aacgggctgt gagcagttgc ttgcatccat tcaaaaagaa aaacaattgt 844441 gagtgaaagg agaatttgca tgaacaacga acgtttaatg ctgaaaggga tatttctcgg 844501 agctgcggca ggcgcggcgt tatcactgct ccataagccg acaagacagg cgtgcgggat 844561 gagatggctg acatgcaagc ataaactttc actgtacaaa agcaacccag agctgttaaa 844621 aaacactgtc atcacaaaag tggatgaggc caaaaagctc gcccgaacgc tttcaaagga 844681 agtcgacttt gtgaaccagc aggtgaaaga gctgaagaaa acaacgccgc aagtgatgga 844741 actcgtgcaa gaaacgaaag agcatttttc aaaaaaatga tcaaacatgc gaggtgagac 844801 gacatgagtt ttttgaaaga gcttttcagc agatacaccc ttcatgaagg acaaagtaaa 844861 tcagcggagc tggcgtattt ttttctattg tcactgtttc cgtttttgat ttttatgctg 844921 acgctcaccg cgtatcttcc gctttctacc gatgatgttt taggagtcat agaacaatat 844981 gctcccgcca gtgcgatgtc actcgttgaa tccattaccc atcaaacctt aaataatcga 845041 aatggcggtt tgctgtcatt cgggattatc gccgcattat ggtctgcgtc taatggaatg 845101 aatgcgatcg tccggtcgct gaaccacgcg tatgatgtgg aagaaaaccg ctcttttatc 845161 attgttcgtc taacctcgat ttttttgacg attgccatgg tatttacgat tttagtggct 845221 ttgcttctgc cggtatttgg ccgggagatt ggaaggctcg cttctgactt tgtcggcgcg 845281 tcggatctgt ttttatccgt ctgggccgcc attcgctggg gtgtcagccc gcttgtgctt 845341 ttgattgttt tttccgcgct gtatgtgatt gcgccgaaca aaaagctgtc tctccggttt 845401 gtcatgccgg gtgcggtctt tgcgactatc ggctggatca ttgtcagcac attgttttca 845461 ttttacgtca gcacgtttgc gaactatagc gccacttacg ggagcatcgg gggaatcatc 845521 gttctgatga tttggtttta cttgagcggc attttaatta tcctaggcgg agaaatcaac 845581 gctcttttac ataaacgtaa aaagcttcct gatgaaaatc cctaccatta gcgcacccta 845641 taaacgaact tcggttcaaa aagaagtcgg ggggatatcg tgatgaccaa gcatacgaaa 845701 aaaggcggaa gccataacaa acaaaactcg aaaagcaaat cgagccataa aacaagcgga 845761 agcgccaacg gacaaaacgg ctaccattag cataaaagcc tcctgacatg atgtcgggag 845821 gctttttgat taagaagatg aagaataggt ttcagccggt gaccagcttt tcggtttgcc 845881 cagcacaagg gccagccaca cagagctaag cgtgagagta atgaagtaga acaagtttgc 845941 gctttcaaat gtctgcatat accagccgcc ggcaactggg ccgaggatgc taccgagact 846001 gaatgtaatg ccgcaaagca ggtttcccgc cggcaggagg tgaggcggaa gaaggtctgt 846061 catatagctg atgccaagtg taaaggttga tccgactgcc attcctgcaa taaaaaagca 846121 gccgccgatc acgtagggcg aaggaaatac accggcgatg aaaaagcaaa gagccccagt 846181 cagtaaaatc accagcagca cattccgcct gccgtattta tcgctgagga tgccgagcgg 846241 aaactgaaag ataatgcttc caatcgcaaa tgcgggaagg atgatcgcta ctgcgtctac 846301 tgatatcccc aaacggagcg cgtacaccgg aaagcttccg ttcagcgccg tttccagaaa 846361 gccatagcca aatgtaggca taaaggcaac ccacccaaac agcatggcct gataaaatcg 846421 cctgaaacta ttgtctgatt tggtttcatg aggactggtt tccgggtatg cattttgtag 846481 aaagaaaaca aaaagccacg caaacagact gatgcagccg gacacgataa aaggaagcga 846541 cggactcagc ttgacaagcg gcaccatgaa cgggcctgcg gcaaagccaa ggccaaagga 846601 aagcccataa atagacaggt ttcttccgcg attttgtttt gatgacatgg aggtcaccca 846661 cgtttgcgta gaaaagtgaa gcatgtggtc gccgattcca atgaacaggc gaagcaggaa 846721 ccagacccaa actgactgaa gccaaataaa tccgaataag cttaaaatga caatgcttcc 846781 gcccatgacg atcagcggct tgaacccgag ctttctgagc ggtgcttcca taaacggcga 846841 agccaaaagc acaccgatat acagcccggt cgcgtgcagg ccgttgatag cagcggattc 846901 tccatttgtt tcaaaaatga ttgaaatgac aggcagcagc atgccttgtg aaaacccgga 846961 aatggaaacg agcaagacaa ggataaagaa atgaaatcgt gacatcgtgt cagttctcct 847021 tatatggaat ctatgttgat cgtacaacgt tttccaaaag caggcaacct gaaaaaagcc 847081 tatatcacgc tatacatttg ccctcgtgta atcatgaagg tttttgtgaa gaataaaaat 847141 aaaacaagtc ataaaaaagg agctatttca ccatgaatcg tatctttttt attttagtgg 847201 cggccggtgt tccgctttct gtgattggca gtttgatgca ttggccttcc gcggttctat 847261 ttgcagttta ttgcgtgacg attatcgcgc ttgcaagcta tatggggagg gcgacagaat 847321 cactgtccat cattgcagga ccgcgtatcg gcggtttgtt gaatgcaacc ttcgggaatg 847381 cggtggagct gattatttcc ctttttgcat taaaagaagg cctgacagga atcgtgcttg 847441 cctctttaac cggttcagtg ctggggaacc tgttgctggt agcgggccta tcgttttttg 847501 tcggcggttt aaaatataag cggcaggaat ttaatatcca tgatgcccgc cataactccg 847561 ggcttctgat ttttgccatc attgtcgcct ttgtgattcc ggaggtattc tctgttggta 847621 tgggaaacgc cagcaagctc aatttaagca tcggcatcag catcattatg attctgttat 847681 atgtggcggc gctgtacttt aaacttgtca cgcatcgggg cgtttatcag ccgaataatg 847741 ccgctcagac tgaagaagag gaagagccag aatggtcagg gaaggttgcg acgattgtct 847801 tgtttgcggc aacgattgtg gttgcataca tatccgaaaa cctggtccat acctttcact 847861 cggtggctga acagttcggg tggagcgagc tgtttattgg ggtcatcatc gtggcgattg 847921 taggaaatgc ggcggagcat gcgtcagcga ttattatggc cttcaaaaat aaaatggaca 847981 ttgctgttga aattgcagta ggctctacgc tgcagatcgc tatgtttgtc gcaccggttc 848041 tcgtcatctg ttctatcttt tttccgacaa gcatgccgct tgtatttaca ttgcctgagc 848101 tcgtcgcgat ggtatcagcg gttctcttga tgatcgcgat ttcgaatgac ggggattcca 848161 actggtttga aggggcgaca ctgcttgctg catatgtcat tatggcgatc ggctttttcc 848221 ttctttaacc tgaaaaaatg atggataaca acaaagcggg atgaaaagac taagggaaaa 848281 tgccatagaa agagtgatat gatgaaaaag ctatttcatt ccacacttat tgtgttgtta 848341 ttctttagtt ttttcggcgt tcagcccatc cacgcgaaaa agcagtttaa ggttcctaat 848401 tctgtcgcaa gcatttcaaa ggaaaacacg tatccgaatg cttcacagga tcagccaatg 848461 cttcagccga gcaagctggc aaaggaattg ctcgatcatt ctgaggtaaa gattgaaaat 848521 ccgcatctca tcaaaatgct gaatgaatcc aacatatccg gcacaccgct tgcagtaggg 848581 taccgggcga caatatttct cgggaaatgg gcgctcggct atgaatcaaa tgaaacagtc 848641 gcaaactggg aatataaaaa aatcaataca aaccgtgcgg ataaccgcgg cgggaaagaa 848701 acggctgaaa tgcattatgc ccaggaacag cagtacagag tgaagggcgg cttgacagct 848761 aaagttccaa atgctgaaga tgtcaaaagc atgatgatgc aaaaagcaat gaagaaaacg 848821 aacctcccgc ttgcatttga gacggtcatc ggggctggca caaaacggga tcagatttat 848881 aaagtcgctc ctaaaaaaat cggttatcta catgcatatg caccggctgt gaatgaaaaa 848941 ggaaaagtga cttacggaga agtgtactta gtgctgaaag gaaataaacg aaaactcgtc 849001 gtgaaaaatg tcacgtcaca gggaatcggc gcgtggattc cggttcaaga tcatgtcacg 849061 tttggctttc agctttcctc actgccaaga taaataaaaa actgattcca actcggaatc 849121 agtttttttg tttattgggt tctctcgatt cggaccgctt cctcaagcat ttgcacattg 849181 ttttggtaga gctggcgaac gagaacccgt cttactgcaa ggctggcact gaaataatca 849241 tcatctttca ccatgccttt aaccgtaaat tcgacgccgc gattgatttt attcaatgcg 849301 gtgatgccgt ggatttgaaa cggttctgtc ggattgccga attcatcccg cttcaatgaa 849361 tcacgaagct cttcattcag catgtcacat gcctcttcca acacgctgta cacgcggtcc 849421 ggatcttctt taaagctgat aagaaaggat tcggtaatcc gcataaaatc aatattatag 849481 ttctctattt gtctgacctc gccgttgctg atggtgagca gcttcccgct ccattcccgg 849541 atttgcagcg agcggaggcc gatttcctcc actgtcccgt tgaacaagtt gttgacggtg 849601 acataatcgc ctttgtgcag ctggcgttca tatattaaga atacaccagc cagcacatct 849661 ttgatcagcg attgggcgcc aaaaccgatc acgatacctg ctacgcccgc cccggccaat 849721 atcttgccga aatcatgcac aaataaagaa ataacgtaaa agataaaacc aattgttgcc 849781 gtatactggg tgacagaacg gacaaggctt tcaatcgttt tttccttttt ttcttcaata 849841 aagtccgtcc gtttaaaaaa tagctgtacc agccggttga tgataaagac accgatccaa 849901 aggataacgg caacgaggag aatatcgacg attttatttt gaaaaatctc cgtaagtgtt 849961 tctttcatcc gcatctaact cctggcttga cgttttgtga agtctgtatc ctgataataa 850021 ctgtttttga caagaacatt cggtccgagg caccggacat tcgggcagtg gcaactcagt 850081 tctttcgcaa gcttggtctc tctccacttt tcataggcgg aagggaggct gtccgtctga 850141 atgttgccaa gcggcggggt atcaccgaaa tcggtcacga taatgtttcc gtcgaaaatg 850201 ttcacattca ggcgggatcg gccgtcaggg tcatttcgca ctgtgacgtt tttcgccgcg 850261 cgaagccggc gaagcagctt ttggtcgtct tcgtccggac tgcaggcata aaacggcagc 850321 gttccgaaca gcatccacgt attttcatca cgaatatcca gcaagcggtg aatggcctgt 850381 ctcatctctt tcaggctgag ggattcaaga gcgcttgcga aatcgcttgg atacattggg 850441 tggacctcgt gacgctgaca tttcatatct tctgtgattt ggcggtgaat atgctcaata 850501 tgcggaagtg ttcgtttgtt cagcatcgtt tccgcagata ccattactcc ggcatccacg 850561 agcgtgcggc tgttttcgat cattttttca aaatagcgcg cgcgctgttc gaaggtcggt 850621 tttctgtcca tcatggcaaa gccgatttca gcaaaatctt caactgttcc ccagttatgt 850681 gaaatatgta gcacatcgag atacggaatg atccattcgt accgctcgat gtcgagggtc 850741 agatttgaat taatttgtgt ccgcacaccc cgttcatggg catatttcaa taaaggaaca 850801 acatattctt ttactgattt caacgaaagc atcggctctc cgcctgtgat gctgatggat 850861 ctgaggcgcg ggatttcctc cagccgtttt aacagaagat ctattggcag agcattcggg 850921 tctttaggct gcaatgtata gcctacagca caatgctcgc atctcatatt gcacagtgtc 850981 gttgttgtga attcaacgtt tgtcagctgc atgtctccgt attggtcaac atccatatag 851041 gcttcccaag ggtcaaactc gggcgtaatc ggacgcagct tcgtgttttg tgtcatgact 851101 atctaactcc tttataaatg ggcatactaa cgctgccaac agttaatttt agacctgatt 851161 tgccaagatc gcaagtagcg cggcgattga aaaacggcaa aaaatgagct accataataa 851221 aaaatgaatg gaggaacaga atggggaacg ccgtaaacaa taaagatcag cagattgatt 851281 atttaaagaa cagacttgac atgtttatga acgtcatcga ttcattagac cctgaagcaa 851341 ccgacgttga agatatagac aggcttatca gcatgcttga tgacctggaa gccaaatacg 851401 aacgttttaa aaaagattgg gaataaaacc gcgtgcccgc cgcggttttt ttattggcat 851461 aaagcaacag tataaaacaa agtctctatc tgtaaaataa gaaaaaatgc agaaggagcg 851521 ctggccatga agtggatgtg ttcaatatgc tgcgccgccg tattgcttgc cggaggtgca 851581 gcacaggcgg aagcggtgcc gaatgagccg attaattggg gctttaaacg aagtgtcaat 851641 catcagccgc cagatgccgg gaagcagctg aacagtttaa ttgaaaaata tgacgcgttt 851701 tatttaggga atacaaagga aaaaacgatt tacttaacgt ttgataacgg atatgaaaat 851761 ggctatacgc caaaagtgct tgatgtctta aaaaaacatc gcgtaacagg aacgtttttt 851821 gtcaccgggc atttcgtaaa ggaccagcct cagctgatca aacgaatgtc agatgagggc 851881 catattatcg gcaatcattc ctttcaccat ccggatttaa cgacaaaaac agctgatcag 851941 attcaggatg aacttgattc agtcaacgaa gaggtttata aaattacggg aaagcaggac 852001 aacctgtatt tgcgtccgcc gcgcggcgtg ttcagtgagt acgtactgaa agaaacgaaa 852061 cgcctcggct atcaaaccgt tttctggtcg gtcgcttttg ttgattggaa aatcaacaac 852121 caaaagggaa agaaatatgc ctacgatcat atgatcaagc aggcgcaccc gggagccatt 852181 tacctgcttc acaccgtatc gagggacaat gcagaagcgc tggatgacgc gattacagat 852241 ctgaaaaaac agggctacac ttttaaaagc attgatgatc tgatgtttga gaaagaaatg 852301 aggctgccgt ctttgtaaaa gagaaagacc tctccttaaa cggagaggct tttctttatt 852361 ttatacattt aatcagtgcg gcccagtcca gatccccgaa gcctttctca atcccgcttt 852421 caaaatggct cttggccagc tcggcaagag gaagatttgc agaaacccgt tttgcggcgg 852481 cgagtgccag gttggtatcc ttcagcccta aagacatttt gaagccggcc ggctcaaatt 852541 tctgctcggc cataatggtt ccgtaatttt gatagactgg agaaccaaag agcgcgctgg 852601 cgatttctaa aaattgtttt tgttctaagc cgtatttctc catcattaaa aaggattcag 852661 ataacgcctc cagcatggac acaagcaaga aattaatgct gattttggct gcatttgccg 852721 tcttgctttc ttcgccgacg tcaaatatct gctggctcag gctgtcgagc agaggcttgg 852781 cagcttgctt tgcttccgcc ggtccggctg ttatgatacg gagcgcggct ttggctgcgg 852841 catccggtct gccaaggaca ggagcggcga gaaaaaattg tcctttctct gcatgagccg 852901 ctgcgagctt ttctgagaac tcaacactga ttgtgctcat cgagatgtgt atgccgttct 852961 ctgctaatcc ttcaagcagc ccgtcttctc cgaatgtcac ggtgctgaca gaatcatcat 853021 ctgcaagcat tgtgatgaca atatcagcgg actttgccgc cagccgcggc gtatcagctg 853081 cctgtgcgcc ttctgtgaca aggtcttctg tcttttgttt cgtccggtta tagacagtca 853141 attcgtagcc tgcttgaaga acatttcggg caatgggctg tcccatattg ccgagtccga 853201 tgacagcaat tttcaatcta atcactccct gaatattttt tccattataa acaatatgaa 853261 cagaatatgc atagcgatcg gcttacaaca aaaaagaaca gctgctcgct gtcctcattt 853321 aaaaatattg aaccatcctt tatgtacaaa ccaaatcagc attccaatca caagcgcggc 853381 catcaggcca agtacagcga aatatccgta tttccaatgc agctccggca taaagtcgaa 853441 gttcataccg tatacaccgg caataaaggt gagcgggatg aaaatggttg atacgatcgt 853501 cagtgtcatc ataatcgcat tcatccggtt tgagtttagc gtcacgtagc tgtcacgcaa 853561 gtcggacgtc atgtcacggt tggattccac aatttcagac aactttaaca aatgatcata 853621 tatgtcgctg aaataggctt tcgtttcccg ctgctctttc acatggtcaa ggcttaaaat 853681 ccggtagagc aaatcacgca tcgggataat cgtccgtctc aaatgcaata ggtctgttct 853741 gagatcaaac acctcgttca tcagcgttcc atacgttttg tggggacggc tttcttcaat 853801 ttcattcagc cggtcttcaa ttttatacac gagaggaaaa tattcatcaa caagctgatc 853861 catgatcata taagaaatat gcccgggccc ttttttcaat atgtccggtg aagcatacaa 853921 acgctcccgg actttagcga taccgggcgt ttcgtgtaaa tgaaaggtga cgacaaattt 853981 ttcgccttga aagatatcga cttcctccgt ctcaagtgtt tccttattca gcgcatgaat 854041 cacgtaaaaa cgatagccgt cataatggtc aagctttggc cgctgcatat gctggaagca 854101 atcctcaatg gcaagcgggt gaaaatgaaa aaaatctctc aataacgccg tttccgtatc 854161 ctccgggccg taaaaatcaa cccagtacca tgcaatatca ggctgttcca ctcgttcgat 854221 cggtatattt ttcagcagct gatgctctgt tgtgattgcg gtaatgttga tcataaacaa 854281 ccctccacct gccattatat catgcggtct ttatgagaaa agtatacggt actctctgcc 854341 taattccagc ggcatgttat actgaacaaa aacggaaaaa agggtggatc tcatgtggaa 854401 ggaaaaagta tctgtcacgc ctccgtatca ttttgaccgc gtgctggaca ggctgtcttt 854461 agaccccctc aatgctgttg atcgagaggc gagggaagtc cgtgtgccaa tcagaaatca 854521 agcgggggac gtatgtattg taaaggtaca ggcgttaggc catgcgggcg agcctgagtt 854581 cctcgtcagc ggggaaacgg atcagggaga aatgatgaag gaaatcaagc ggatttttca 854641 atgggaaaat catttgcagc acgttctgga tcatttttca aaaacgagcc tgtccgccat 854701 ttttgaagag catgccggga cgccgcttgt tctggactac agcgtgtaca actgcatgat 854761 gaaatgcatt atccaccagc agcttaatct ttccttcgct tacacgctaa cagaacggtt 854821 tgttcatgcg tttggcgagc agaaggatgg cgtgtggtgc tatccaaagc cggaaacgat 854881 tgcggaactc gattatcagg atctgcgtga tctgcaattc agcatgagaa aagcggaata 854941 caccattgat acatcaagga tgatcgcaga aggcacactc agcttgtcag agctgccgca 855001 tatggcggat gaagacatta tgaagaaact gatcaaaatc aggggtatcg gcccgtggac 855061 cgtgcaaaac gtcctcatgt tcggacttgg ccgtcccaat ttattcccgc ttgccgatat 855121 cggcctccag aatgccatca aacgccactt tcagctggac gataagccgg caaaggatgt 855181 catgctggcg atgagcaagg agtgggagcc ttatttaagc tatgcgtctt tgtatttgtg 855241 gaggagtata gaataattcg tctgacaatg aaggaaatcc tgcaaacgtg ttatactaga 855301 aagatgtgaa aaaaccattt cactttctgc catccgcaga aagcttcata tagaaacgga 855361 gagaacaacg tgaaccaaca aaagaaacag gcgcccgtcg aactgaaggt cggacaaact 855421 tttccgctga cgattaagcg tctcggcatt aacggagaag gtgttggcta ttttaagaaa 855481 aaagtcgtct tcgtgcccgg cgcgcttcct ggcgaagaag ttgttgtgca ggccacaaag 855541 gtccagccga agttttcgga gggccgcatt aagaaaatcc gcaaggcatc tgagcaccgg 855601 gtggcaccgc cttgccctgt ttatgaacaa tgcggcggct gtcagcttca gcaccttgca 855661 tacagccagc agcttcggga aaaacgtgat atcgtcattc agtctcttga acgccatacg 855721 aagtttaaag ttgaaaacat ggaaatcaaa gaaacgattg gcatggacaa cccgtggaat 855781 taccgcaata aaagccaatt ccagatcggg cgctcgcaaa gcggcagcat catcgccggc 855841 ttatacggcc ttgattctca tgatatcgtg ccgattaaag actgtatcgt tcagcatccg 855901 gcaacgaaca aaacaacagg catcgtccgc cgcattttag aggacttcaa tgtgtctgtt 855961 tataatgaaa gaaaacgaaa aggcgacgtt cgcacgatcg tgacgagagt cggctttgaa 856021 acaggcgaag tgcaggtcgt gcttgtaacc gcaaaagaaa cgcttccgca caaggaagaa 856081 atcgtcaaag cgattcaaaa gcgattgcca gaggtcaaat ccattattca gaatgtaaac 856141 ggggcgaaaa cctcagtgat ttttggtgag aaaacaaaac agctcgccgg aaaaacagtg 856201 attcaagaag tgctcggcga cgtatctttt gaattgagcg cccgcgcttt cttccagctc 856261 aatccggaac agaccgtcaa gctgtatgat gaagtgaaaa aagcggcgca gctgaccgga 856321 aaagaaaaag tcgttgatgc gtattgcggc gtcggcacta tcggcatgtg ggttgcggac 856381 ggagcgaagg aagtccgcgg catggacgtc atcaaggaat caattgacga tgctaagaaa 856441 aacgccaaaa aacacggcat ggcaaatgcc acatacgtaa caggaacagc cgagcactgg 856501 ctcccgaaat ggacgaaaga aggcttccgc ccggacgtcg tcattgtaga cccgccaaga 856561 acgggctgtg acagcacgtt cttggacacg atcaaaaaag tcaaaccgaa acgctttgtc 856621 tacgtttcct gcaatccatc cacgcttgcg aaagatttgc agacgctgtc gaaggactat 856681 cgcgtggact atattcagcc tgtcgatatg tttccgcaga cggcgcatgt tgaagcagtg 856741 gcgaggcttg tattaaaatc gtctaactaa aaagaacatt tcccagtcat aaaatagttt 856801 tcctaataag acctggattt cggtaaaata aacaattccg atttccgggt ctttttcgtg 856861 cgcagctctt gtcctaacgg tctgttctca attttatctt ccttcttttc gcggagatct 856921 ttattttaac tggcgaaaag aattgaaaaa acgtgttgaa aagcaggtga aaaaaagcgt 856981 tatttaaccg gaaaaatatc ctcccagtat gtttaaaata catgagtaga atgatgtaaa 857041 atcatagatg tattttcata atttgtaaaa ttatatattg acttgcagtt attacgtgtg 857101 aaatattgat gataggaata taaggaaagt atggcgtata tcatttcaag agtcattcga 857161 tgtaaaaagt tgaaacattg taataaatga aagaggtgaa aatgatggcc aaccccattt 857221 taaaatgcat aacgtatgag cactacaaca attaaataat agtgccgaga cgataacaac 857281 tattacagta atacctacaa tggttatatc cttgcgacaa tcatgcttca taatataatg 857341 attttagatt gacacttggc taaaaagtat tgcagagaag gaaatggata attaaatgga 857401 taaagtatat aaaagaagtt ggtttcaaac atttttggca tttttagtat ctcagcttta 857461 ttttaatttt gtagaattaa cgggatgggg tcctaagtat agagaaatga atggattccc 857521 agcaaacata gttgaactag atttctttca aacatatctt tcattctatg ataatccatg 857581 gtttaatatt attactgttt tcttgggagt tttcactatt atacaaataa ttacagggat 857641 aacaaaggat attcgaaatt aaagcaataa cttctgatgc cttatttaat gatgaaagaa 857701 aatgtacact ttcttaatta tcttatgagt gaagactgcg acacttagtc agcagtctat 857761 tttatggttc tggatcagga ttaccgaatt ataaccctat acaaatatat agtaggttgc 857821 cacttgctgc gttggttatt ttctaaatca tgagcaaatc ccaaatgatt cagattgaag 857881 ttcttgaatt cttttaaata agggtttatt ttctcttctc atcctcttta ctccatgtga 857941 ttcacaagtg gtagcagctt aagtaggttt tttcattctc ttgagtactc agttatacca 858001 cccccaactc aatttgcttt atctctatta gtttttccgc aaatatgata tagagatacg 858061 gatatggtgt agtgttaaat atcttatctt caataacagg gcaattattt tgcgttggta 858121 atatggagaa ctcatatgat attctattta ggttggaatc ctttttatcc aaaaagttca 858181 aaagcaaggc cactaagaaa gacgaaggtc agcgccagtt aaccagaata taaaaaatag 858241 ggtagataat catcccacgt gaaatcttca aaatttacta tagattgata agaaatgctt 858301 tcgcatgcga taagtgtaaa agaagcatgg tcagttttta atttgggata aaggttcagc 858361 cgtatcccat aatgaaagga tttgattttt gttatgacag aaaatttctg gcgtgaatta 858421 ccacggccgt tttttgtact ggcaccaatg gaagatgtga cagatgttgt tttccggcat 858481 gtagtaagtg aagcaggcag accggatgtg ttttttacag agttcacaaa ctcagagagc 858541 tattgccacc cggatgggaa ggatagcgtg cgcggccgtt tgacttttac agaggatgaa 858601 cagccaattg tggcccatat atggggagat aagcctgaaa acttccgtaa aatgagtatt 858661 ggcatggcag agttaggatt taaaggacta gatatcaata tgggctgccc tgtgcctaat 858721 gtggcgggga atggaaaggg aagcggcctt atttgccgtc ctgcagttgc ggcagaatta 858781 atacaagctg caaaagcagg gggattgcct gtaagcgtga agacaagact tggatacacg 858841 gatgtggatg aatggcgcga gtggctgaca cacattttga aacaggatat tgcgaatctt 858901 tctattcatc tgcgtacaag ggcagaaatg agcaaagtag atgcgcattg ggagctcatc 858961 ccagagatta agaaacttcg tgacgaggtg gcaccagata cattgctaac aataaacggg 859021 gatattcctg accgtcaaac tggcttgaaa cttgctgaac aatacggcgt cgatggaatt 859081 atgatagggc gcggtatttt tacaaatcct ttcgcttttg aaaaggagcc gaaagagcat 859141 agcagcaagg aattgcttga tctcttaagg ctgcatctgg atctccatga tgaatattca 859201 aaagaagaag cccgtccata caagcctctt cctcgctttt tcaagattta tctccgcgga 859261 ttccgagggg caagtgaatt aagaaatcaa tgcatgaaca caaagtcaac agatgaagtg 859321 cgtgcattgc tcgacgactt tgagagaaag tatcttgatg ggatagagta acagcagtgc 859381 ttgattcaaa aaaggctaac aaaataaagg gatttttaca caattcttga ctaaaataaa 859441 cctggatttt cggtaaatcc gggtcttttt tgtacgcagc ttttactcag cctgtctttt 859501 ctctaattta ttgtaagaaa ataatggtat atttagtgga gatatcatat aaagggggag 859561 aggaaaatga aacggctatg catcatcccc tgcggcaaga aaaaaatctg ggatgtccag 859621 cctgatgccg ggccggtaag agcagaggac gcttatctca gcccgtttca tcaggcgtgc 859681 gagcggtatg caaaaacatt tttcgatgag tgggtgattt tgtcggcgaa gcacgggttc 859741 ctccgccctg atgatctcgt ttcgggaaat tacgatgtca cttttggcac cggtcatccg 859801 gaaatcatga cagcggacga gctgcgccgt caatttcacg aaaaaggctt ttctgatatc 859861 gaagagctag tcatgcttgg cggaaaaaaa tatcgaagcg ttctaaacgc cgtcatcgga 859921 gaacaccagc atatcagctg gccgctatca tcatacaaag gcataggcta tatgctccaa 859981 gcgctgaacc gggctgttga agaaaagcat gaactgtagc acgtacatat gaggaaaaga 860041 gtgggaacat gaaaaaactt gtgtttggct tgcttgccat tgtgttattc ggatgcggac 860101 tatatatcta tcatgtatgg ttcggtgatc cattttcgaa aaatgctgca gaacagaagc 860161 tagtgtctta tgtgaaacaa acctatccta agaaagaaat caagatcacg aatggggtat 860221 ataacgctaa aacgtctgaa tatgtatttg aagcaacctc ccaatctcat cgctacccaa 860281 tgtgtacgaa gggatttctg catcctaaag taacgtgcga tggaattgaa gaagcgtata 860341 ccgaatcagt agcaaaacat gtaaatgaag aagcaacgaa ggcaatcgaa gcagatctga 860401 aaaaagcggt tcctcgattt ataaaagctg atgctgcttt gagtatcgaa aacggacagt 860461 tcacgttaga tacaaaatgg aacaaaaagc tggctgaaaa agcgcctatg agcatgacga 860521 ttcagttaga cgccagcggg ttatcaaaaa cagatgccgc aaagatggcg gaaacggtca 860581 gaaaaacgct taatgaaaag ggatatacat actcaaacgg cacgatagac tgtatgcaga 860641 aggacgggga cggcggtatt ggatatgtca aatattcaat tgattttctt tcaaaagcag 860701 ctattcagtc aaacgatgca gaggaactag gaagttaaaa agatttccaa ggaaataaat 860761 acgtcgatca ttgtcaaagg ccgggtgata tccggtcttt tttttgcatg ctgtaaaacg 860821 agacaaatga atcagtttga gacaaaacga gacacacgtc tcaaactgtc tccaaagtga 860881 agatgagaag actgatttta cgggctcaaa agactggcac acttcttgca tttataatgg 860941 tgaaccctaa atagaaggag gcgcacaaaa tgaaattgtt aaaacgagaa ggcttgtcat 861001 taactgagga aaaagcgctg tggatgtacc aaaagatgct ggagatcagg ggctttgaag 861061 acaaagtgca tgaactgttc gcccagggag tgcttcccgg attcgttcat ttatatgccg 861121 gtgaggaagc cgtggctgta ggggtgtgcg ctcatttaca tgatggcgac agcattacaa 861181 gcacccacag gggacatgga cattgtatcg ccaaaggctg tgacctggac ggcatgatgg 861241 cggaaatttt cgggaaagcg accggattgt gcaaaggcaa gggcggttct atgcacattg 861301 cggatcttga taaaggcatg ttaggcgcaa atggaatcgt cgggggcggc tttacgctcg 861361 catgcggatc agcgctcacg gctaaatata aacagactaa aaatgtaagc gtttgctttt 861421 tcggggacgg ggcaaataac caaggtacct tccacgaagg gctgaattta gcggctgtat 861481 ggaaccttcc tgtcgtattt gttgctgaaa acaacggcta tggcgaagct accccatttg 861541 agtacgcatc agcctgtgat tcaatcgccg atcgggcggc tgcttataac atgccggggg 861601 ttacagttga cggcaaagat attttagcag tttaccaggc agccgaggaa gcgatagaaa 861661 gagcaagaaa cggcggcggc ccgtctttga ttgaatgtat gacctacaga aactacggcc 861721 atttcgaagg agatgcccaa acctataaaa cgaaggatga aagagttgag caccttgaag 861781 aaaaagatgc cattcaaggt tttaaaaact accttttaaa agaaacagat gctaataagc 861841 tgtcagacat tgaacagcgt gtcagcgaat cgattgaaaa agccgtctcg ttcagcgaag 861901 acagcccata tccaaaagat tcggagctgc tgacagatgt gtatgtgtca tatgaaaaag 861961 gaggaatgta agagatggcg agagtcataa gcatgtcaga cgcgatcaat gaagcaatga 862021 agcttgcgat gagaaaagac gaaaatgtgc ttttgatcgg tgaggatgtc gccgggggag 862081 cggcggtcga tcatttgcag gatgatgaag catggggcgg tgtattaggg gtcacaaagg 862141 gactcgtaca ggaattcggg cgtacaagag tgctggacac tccgatttct gaggcaggct 862201 atatgggagc ggctatggct gcggcatcaa ccggtttgag accgattgcc gagctgatgt 862261 ttaacgattt tatcggcacg tgctttgatc aggtgatcaa ccaaggggcg aaattccgtt 862321 atatgttcgg cggaaaagcg caagtgccga ttaccgtccg caccacatac ggagcagggt 862381 tccgggccgc tgcccagcat tcacaatcgc tgtatggcct tttcacgagc atccctggac 862441 tgaagacagt tgttccatcc aatccgtatg atgccaaagg tcttttgctt gcagcaatag 862501 aagataatga tccggtgttt ttctttgaag acaaaacgtc ctacaacatg aagggcgagg 862561 tgccggaaga ttattataca attcccctcg gaaaagcgga tatcaaacgc gaaggcaatg 862621 atgttacgct ctttgcagtc ggcaagcagg tcaatactgc gcttgaagcg gctgcacagc 862681 tttcagagag gggcatcgaa gccgaggtcc ttgatccccg cagtctgtct cctctggatg 862741 aggatgcgat tttcacatcg ttagaaaaaa caaaccggct gatcatcatt gatgaagcca 862801 atccgcgatg cagcattgcc acggatattg ctgcgcttgt cgctgacaag ggctttgatt 862861 tgcttgatgc gccgattaaa cggattacag cgccgcatac accggttccg ttttcaccag 862921 tgcttgaaga tcaatatttg ccgacaccag ataaaattgt cagcgtcacg cttgaattgc 862981 ttggcgagcc ggcattgaat taaagggggg acacaaatgg cggtaaaagt agtgatgcca 863041 aaattgggaa tggccatgaa acaaggggaa gtatcgatat ggaataaaaa agtaggcgac 863101 ccggttgaaa agggagaaag cattgccagc attcaatcgg agaaaattga aatggagatc 863161 gaagcgcctg aaaaaggaac gctgatcgat atcaaagtga aagagggaga agaggttccg 863221 cccggcacag ctatctgcta tatcggggac gccaatgagt cggtgcagga agaggcgggg 863281 gcgcctgttg ctgaagacaa tatgccgcaa gccgtccagc ccgtcaaaca agaaaacaaa 863341 cccgcagcct ccaaaaaaga tcgaatgaaa atatctccag tcgccaggaa aatagcagaa 863401 aaagcaggat tagacctaaa acaactgaaa ggaactggac caggcggacg aatcgtgaag 863461 gatgacgtaa caaaggctct tgctgaacag aaaaaagatc aagcaaagcc tgtttcggag 863521 cagaaagcgc aggaaatccc ggtgacaggc atgagaaagg tcatcgctgc ccgaatgcag 863581 gaaagcctgg caaacagcgc gcagctgacg atcacgatga aagctgatat caccaagctt 863641 gccactcttc aaaaacagct ttcaccaact gcggaagaga gatacggcac aaaactgacg 863701 atcactcatt ttgtctcaag agccgccgtt ctcgctctgc aagctcaccc tgtgctgaac 863761 agcttttatc aaaatgagcg catcatcaca catccccatg tgcaccttgg tatggctgta 863821 gccttggaaa atggcttagt ggtgcctgtc atccgccatg ctgaaaagct atcgctgatt 863881 gaactggctc aatccatctc agaaaatgcc aaaaaagcac gcgagggacg tgcgggaagc 863941 gaagaactgc aaggatctac tttctccatt acaaaccttg gcgcgtttgg agttgagcat 864001 ttcacaccga tactaaatcc gccggaaaca ggcattctcg gcatcggagc aagctatgac 864061 acaccggtgt atcaagggga ggagatcgtc agaagcacga tcctgccact cagcctgaca 864121 tttgatcaca gagcgtgtga cggcgcccct gccgctgcat tcctgaaggc gatgaaaaca 864181 tatttggaag aacccgcagc attaatttta taggaaaagc aggtgaaaac gacatgacat 864241 tagccattat cggcggcgga cctgcaggct atgcggctgc ggtttccgcg gcacagcagg 864301 gcagaaacgt gctgctcatt gacaaaggca agcttggggg gacctgcctg aatgaaggct 864361 gcatcccgac aaagtctttg ttagaaagcg caaacgttct tgataaaatc aagcatgccg 864421 acagctttgg aatcgaactt ccggcaggtg cgatatcagt cgattggagt aaaatgcaaa 864481 gccgaaaaca acaggttgtc agtcagcttg tccaaggcgt tcagtaccta atgaagaaaa 864541 atcaaataca ggttgtaaag ggaacagcct cctttctttc tgaaagaaag ctcttgatcg 864601 aaggagaaaa cggaaaagaa atcagagagg cggaccaagt attgattgcc tccgggtcag 864661 agccaatcga gctgcctttt gccccatttg acggcgaatg gatcctcgac agcaaagacg 864721 cgctttctct ttccgagatt ccgtcttcac tagtcattgt cggcggcggt gtcatcgggt 864781 gtgagtatgc agggctgttc gccagattgg gatcgcaggt gaccatcatt gaaacagcgg 864841 accggctgat cccggctgaa gatgaagata ttgcccgtct ctttcaggag aaacttgagg 864901 aagacggtgt cgaagtgcat acttcatcca gattagggcg ggtggatcaa acggccaaaa 864961 cggcaatatg gaaaagcggt cagcgagagt ttaaaacgaa ggccgattat gtgctggtgg 865021 cgatcggcag aaaaccccgt cttgacggat tgcagctgga acaggccgga gttgattttt 865081 ctccaaaggg cattccggtg aatgggcaca tgcagacgaa cgtgcctcat atttacgcgt 865141 gcggagatgc tatagggggc attcagctcg cgcatgccgc tttccatgag ggcatcatcg 865201 ctgcttctca tgcttccgga agggatgtca aaatcaatga gaaacatgtg ccgcgctgca 865261 tctatacgtc cccggaaatc gcgtgtatcg gaatgacaga acgacaggca agaagcatat 865321 acggggatgt gaagatcggc gaattttcat tttccgcaaa cggcaaggcg ctcattaaac 865381 agcaagcgga aggaaaggtc aaaatcatgg ctgaaccgga attcggcgaa atcgtgggtg 865441 tctcgatgat tggcccggat gtaaccgagc tcatcggcca agcggcagcg atcatgaatg 865501 gtgagatgac ggcagatatg gcggagcatt ttatcgccgc ccatccgact ttatcggaaa 865561 cattgcatga ggcgctgtta agcacgatcg gccttgcggt acatgcataa taaaggaaaa 865621 agcaggcgca tggatataag gcgcctgctt ttttattgtt gaaagcgctt tatttttccc 865681 ctacaataga tgaaaacggc gtgtaaggga ggagcgatca aggaaatgaa ttcggtccca 865741 aacgatttgc aaacctggaa acgttttgtg aaagacggtg tgcttgacga agcccgatta 865801 agaaaacgga ttgcagagtc atggcatcgc tgcaaaaaag ctgaggtcaa tccttattta 865861 gaaaaaggcc cgaaggtttt acagcaaacg gagctggatc agcagtcaaa aaaacattca 865921 ttcttcttga cgaccgcaaa gccttacctc gaaaaactgc tgcctgccat aaaagaaatg 865981 gaaatgatgg cgctgttaat tgattcagac ggtgttgttc tggcattgga cggccatccg 866041 cgcgcgctct atgaagccaa acgcatcaat ttcgtcgaag gggcatgctg gacagaaacg 866101 gctgtcggaa caaatgcgat tggcacggcg ctccacatca gcgagccggt tgcaatacaa 866161 ggatcagagc attactctat cgcttcccat ctttggaact gttcagctgc tccgattcac 866221 catgaggatg gcagccttgc gggtgtaatt gacatatcat gcccggcggc aggcgcgcat 866281 cctcatatgc ttggtattgc cacggcgatt gcctatgccg ctgaacggga actcgcagct 866341 aaaagccgtg agaaagagct ggagctgatc agccgttttg gggagagagc tgcatccagt 866401 gtgccgatgg tgctctgtaa taccaagcag cacatcatca gtgcgagcat gccgattcga 866461 acctcaatgc cggattggca gggccggcac ctgtacgagt tgaaggaacg gggctattca 866521 atcgaaaatg ctgtcaccat aggagatggc ggcacttgtt tttatctttc ggaacaaaag 866581 aaaaagaagg cgtttcgatt caatggagtg atcgggcaaa gcggccgatc gcaagcgatg 866641 ctgatgcacc ttgaacgagc agctgcgacg gatgcatcgg tctgtttgtc gggtgaaacg 866701 ggtacgggga aggaggtcgc ggctcgcgcg cttcatgaga acagtgagag acggcacggt 866761 ccgtttgttg ctgtcaattg cggagcgatt ccgtctgatt tgattgaaag cgaactgttc 866821 ggatatgcag agggcgcttt tacgggagcg aaacgaaatg gctataaagg cgcctttcaa 866881 aaagcgaatc aaggcacatt atttttagat gaaatcggag aaatttccca ctcgatgcag 866941 gttgcacttt tacgggtgct tcaggaacgc aagataacgc caatcggcgg gacgaaagaa 867001 attccggttg atatcagagt tattgccgcc acacattgtg atttacgcga gcttgccgaa 867061 aacggaaaaa tcagagagga cttgttttac cgtcttcatg tctatccaat tgaactccct 867121 ccattacgcg atcgcaccga ggatatcccg gatctctttg agtactacaa acagaagaat 867181 cattggccag gcgatcttcc ttctgatttt tgtaatgtgc tgaagcaatg gaagtggccg 867241 gggaatatcc gcgagctgtt taatgtgttt gaacgtcttt ctatcagatt tccggacggc 867301 cggctgagag atgaatcgct tcccgcttta ctggaagccg ctggattgcc ggccagctct 867361 gcagaaaaaa agccggctgc tgccggcgtg cttacttttc gtgagcaaat ccaaaaggat 867421 atgatgatca aagcgcttga atctgcaaaa ggaaacgtct ctcaagccgc aaaaatcagc 867481 gggatccccc gaagcacttt ctacaaacgc ctgaaaaaat tcaacttgtc cgctgaatca 867541 taaagcatac ttccttcagg aaatggaaac gttatgtatt gaaggagggt gttacgatga 867601 atattcaaag ggcgaaagaa attgtagaat ctcccgacat gaagaaagta acatataacg 867661 gcgttcctat ttacattcag cacgtaaatg aagaaactgg aacagcaaga atttatccgc 867721 ttgacgaacc gcaagaggag catgaagtgc agctgaacag cttaaaagag gattaaacaa 867781 aaatggcccg cttcataagc aggccatttt gttatccgcg cggcgcaaat aaaataacac 867841 agacaccgat gagacaaatg aatgcgccga tccagtcata cagatcaggt gttttccggt 867901 caacaagcca tccccacagg accgcaagca cgatgaatac tccgccataa gcggcgtata 867961 cacggccgaa agatgggaag gactgaaacg tcggaagaat gccgtataca atgaggatca 868021 gcgccccggc gattccgtag ccagctggct ttgcctctct cagccatagc caaaccagat 868081 atccgccgcc aatttcagca agccctgccg cgagaaataa aagaatggta atcagcatca 868141 tgagcactcc tcaatttgca tttatctttc attatagagg aggagagctt ttaaagcttc 868201 ggatgattct caaattcctt caaatacgct tttcgctgaa cctctgtaaa ttggctgatc 868261 caattgtttt gagcctcttc attcaaatgg ggaaggatat agcgttcaac cgcttcgaaa 868321 aacagcggat tcgtgatgat gttccaggtc gggattcgaa cgattttgcc gtctgttttc 868381 tcgatgataa tatcctcaaa aaagatccct ttcaaactgt attgatggcg tcccatataa 868441 agccgcttca cctcggaaaa cagcacgctg cgctttctca agaagatttc gccactaggt 868501 ccggtcttta tggtgaaaat gacatttcca cggcttgtga acgcaggaaa agccataaag 868561 aatgtgatca atccataaat catcgccagt aatccgccgc ccaaataaag cagggcatat 868621 ttagattcaa acgtgagggc ttcagacacc agccagactc ccacaataaa ggcgccccct 868681 gtagcgagga acagccaagc ccttagaaac atcatgcttt ttacttcaat catgtgctgc 868741 ccctaaagct tcggatgatt ctcaaattcc ttcaaatacg cactgcgttg gatgtctgta 868801 aactgtccga tccaattgct tttcgcctct tcattcagat gtggaaggat atagcgttca 868861 accgcttcga aaaacaacgg attcggaatg atgttccaag tgggaatgcg aatggtcttc 868921 tgatccacgg tttggatcaa tatatcttct tggaagattc cttttagact aaatttatgg 868981 cggctcatct caattttctt gatatcagta aacgtaacag acactttgtc agtgaacact 869041 tctccatttt ttcctgtctt gatgcggaaa atggtatttc cccgcggggt gaaagccgga 869101 aagaagatga taaataaata taaacaaaac aaggtgaaca gaaagccagc aggaatggct 869161 aataggtaat atttcgtttg aaacgtaata cccatataaa agagccacaa acatgctaat 869221 cccataccgg cagatccgac aaaagcccat attctcagga acattttgct tttgacttca 869281 atgatttctt ggtttttcaa tgcttttctc cttttgttaa ttcaattctt atcattttga 869341 aatgatttga tttacaacat ccttatgagc agggaggata gaaaattcat tctgggtgat 869401 gcctgtgaca agccaagtat ggtgggcccc cggcaggacg aatgccatgt cagccacttc 869461 aggagtgtta tcttttccat atgccagacg cataagtgta tccattttcc ctttccgcaa 869521 agccagatca tttgcaaatc gggtaacgtc ctcttggtgg tcatgttttt caaggaactc 869581 ttttagatat gaagggttgt ctgaagcgcc ctccaagagt ttttcaaatt catttgatgt 869641 caatgttaca atcgattctc ttttatcctc tgtatctatt atatgtaaaa actcatctgt 869701 cttagcaagt aacccttcac ttgattccat ttttgtaatg cgatggactt gttcatcaaa 869761 aaggagttcg tgagagtagg tgccgaattt tgatacatgg catgacacat tctgttcggc 869821 accttgcccg ttaaatttag aaagcttcac tgtatagtca gcgtcgttta atacatggat 869881 aaacggacag tactcgtcct ttaaccgata ttgatggttc cgatattccg ctgcatcctt 869941 ggctaagagt gagcggcacg cggcttcaaa taaggcgccg agctgttcat cttctatttc 870001 cggaaaatag gcctgcttca aggccattcc ctgttcaaaa aacccttcgc tgtaaaagca 870061 aaacaagagt tcttctatgc taattgtaaa ctgcttcatt gtttattctc ctatccaaat 870121 gaaaatttcc ctttaaggaa atgggttgcg ccgtgtataa gcgaatccgc tgttttcttt 870181 gctttttcca ttcctttttt cgcgctgtct atccctttat gtatcgattt attcgccgca 870241 tctatgccgt cattcactga tttgacgact ttgccggctg attccagccc ttttttggct 870301 gtatcaacaa cagcatggat cggttctttc agctttaagg ctgctttttc agcaaaaccg 870361 gctgtatatt tggcgatttg ttctccgacg actccgccaa tgtatgaacc tgctgcccca 870421 agaaggacag tacccacagg tcctgcaaag cttccgattg caccgccgat gacagcacca 870481 gctgtggcac cgccggcaac aaaaatcgta ttattcacag cattcccgac ggccttggcg 870541 ttttcacgct tgagaacttc cggtttatcc tggtattttg cataattttc agcaattttc 870601 acgcctgctc cgaatgtttc ggtcgctccg gtaatcagtg tggcggtaat ggcatttcct 870661 ttcgcgaatc tcaagcccgt ttttcccaca tccttcaaag tggagcgtac gccggcttca 870721 ttaagaaatc cttttgtgta gcttctgacg ctgtttgaaa aatccaccgt gtcctgagga 870781 aagtattttg taaacttttt atgtaccaaa tctgaaaatg gacggtttgt ctttttcaac 870841 aaatatttag gattcaaaag cactcttgcc gctttttgat aacgtgagct gtcaacggcc 870901 ctggaaatat ccaagagcag ttttgagtgc tgggctgtat gcaagccgct tggttgtttc 870961 acaaatttcg taagccctaa tccgtaatat tttccctgcg tcagcataag agcggttaag 871021 cttgtcatcg taccgtattt gtcgtaggca ttgtagagct ttcgcaaaat atcatcttgt 871081 tccacaaatt tatcgcctgt ttttctgatg aaaatctcat tgtcactcag cttagtgacg 871141 agcgcctttc ctgagctcca cgcatcgccc actccagaaa aacagctgct gtagcgggga 871201 tcgcattgca aaatcatctg ccccagctcc acatgcaggt ccttatattt gttttccata 871261 tcagttaatt cagtgactac atcatttgca agctgttcga gcttatccgg atcaactgca 871321 atgtttcctg acacaccgtt cacctcccga gtttatgtct ttcctctctt gctttacgct 871381 ccagttcttc cattctggca atttcagctt ttcgttcttc tattttgaca gcggcagcct 871441 tcagctcttg gcttgtttca agcagctcct gttcgaattg atcgtaggcg gctttcgttt 871501 cctcgaaatc ctggtcaaac gaatctcttg ctttgccctg ccaagcatct cccaatgcag 871561 ataaccggga ttcaagcagc attttggagc ttctgacctc ttctgcggcc gcactatact 871621 tgtttgccag ctcaatgact ttatatgagt ccaacttttg tcccctgcct tttctaaatt 871681 cacgcacaat tggatgtttt atataaatga ttataaataa ttcggcatgt atccgaatcg 871741 tacaaaagaa ccttttcata agaattggaa gggcgtatat tcacttaaaa ttcacagttg 871801 gtgagacttt aagattacaa aaaaggtaaa aaaaccaaat ctctcagaca taaggcaaat 871861 gagaaatttc ccgctctatg ggaaaaaaca ctaaagttga tcaaatgacc taagtgcgcc 871921 aaacgtgtta cgggacgagc tatctcatgg tataaatgga attgtaaacg ttatcaagga 871981 ggtcgtcata tgaagaaaaa atcattctca atcgtaatag cgggcggagg gagcactttc 872041 actccaggga tcgtactcat gctcttggac catttggagg agtttccgat cagaaagctg 872101 aagctgtatg ataatgataa ggagagacag gatcgaattg caggcgcctg tgacgttttt 872161 atcagagaaa aagcgccgga tattgaattt gcagcgacga ctgacccgga agaagctttt 872221 acagatgtcg attttgttat ggcgcacatc agagtaggga aatacgcgat gcgcgcgctt 872281 gatgagcaaa ttccgttaaa gtacggagtt gtcggccagg agacgtgcgg gccgggcggg 872341 atcgcatacg gtatgcgttc gatcggcggt gtgcttgaaa tattagatta catggaaaaa 872401 tactcgcctg atgcgtggat gctcaattat tccaatccgg cggcaattgt ggctgaagct 872461 acgagacgcc ttagaccgaa ttctaaaatt ctcaatatct gtgatatgcc ggttgggatc 872521 gaagaccgga tggcgcaaat tcttggctta tcctcaagaa aagaaatgaa ggtccgctat 872581 tacggattga atcatttcgg ctggtggaca tcgattcagg atcaagaggg caacgattta 872641 atgccgaagc tgaaggaaca tgtatcccaa tacggttata ttccgaaaac agaggctgaa 872701 gctgtggagg caagctggaa tgacacgttc gccaaagcgc gtgacgtgca ggctgcagat 872761 cctgacacac tgccgaatac gtatttgcaa tattatttgt tcccagatga tatggtgaaa 872821 aaatcaaatc cgaatcatac gcgggcgaat gaagtcatgg aagggcgcga agcttttatt 872881 ttcagccaat gtgacatgat cacacgtgaa cagtcctcgg aaaacagcga aattaaaatc 872941 gatgaccacg catcgtatat cgttgatctt gcccgggcga ttgcctacaa cacaggtgaa 873001 agaatgctgt tgattgttga aaataacggt gcaattgcga actttgaccc gactgcgatg 873061 gttgaggtgc catgcatcgt cggctcaaat ggacctgaac cgattaccgt tggcaccatt 873121 ccgcaattcc agaaagggct catggagcag caggtatccg ttgagaagct gactgttgaa 873181 gcgtgggcag agaaatcgtt ccaaaagctg tggcaggcgc tgatcctgtc aaaaacagtg 873241 ccgaacgcgc gtgtggcaag actcattctt gaggatttag tggaggccaa caaagacttc 873301 tggcctgagc ttgatcaaag cccaacccgc atatcataaa tgaaattccc ccattttcga 873361 atctgtaatt gtatataata gaaagaaaat ggggggatct gatatgcagc tcgaagaact 873421 gatcaatcag cactacagca aattgaatga caacgatttt catattttaa aatatatatt 873481 gaatcataag cacacatgct atcaccttgg aatcgacgcg ctggccaaag cttgcagtgt 873541 atcgcgttcc tcaattttac ggcttgccca aaagctcggt ttcagcggtt acagtgaatt 873601 tcgcgtcttt ttaaagtggg aagatcagcc ggaagaaggc gagagtatga gttttgaaaa 873661 gctgcttgat gatattgaag caaatttgaa gtttttacgg acaaaggaca tgacggacat 873721 gtgccagctg attgatgcag ctgaccgcat tttcgtctac ggttctggaa atgcgcaaaa 873781 gatatgcgcc cgcgacctgc aaagaatgtt tattccgcgc catcgctatc ttattttgat 873841 tgaagacaca aatgaattta atttgatgcg cgatgatttt aaagtgaacg atctgtttat 873901 catcatttct ctttccggag aaacaccgga gctgattcct caggcaagaa tgctttctgc 873961 aaagggtatt ccctttattt ccattacgaa tttaaaaaac aatgtcctcg cccagctgac 874021 tccgcataat ctttatgcga caagcaaacc tgtgacatta agcgatagaa cggaaattgt 874081 cgcttttgca ccgttttttc tcgttggcga agcattgttc cgcgcatatg ttgattacaa 874141 agaggcagaa aaaaatgaca atgagtagca gggggttctg gtatgatgca aaaaattcag 874201 cgctttggaa gcgcgatgtt tgtgcctgtt ttattattcg cgttcgccgg cattatcgtc 874261 ggtatcagca cgctctttaa aaataaaacc ctcatgggac cgctcgccga tcctgacggt 874321 ttttggtatc agtgctggta tatcattgag cagggcggct ggactgtttt taaccaaatg 874381 ccgctcttat tcgccattgg catcccggtt gctttggcga agaaagctca ggcacgcgcc 874441 tgtttggaag cgcttactgt ctacctgaca ttcaactatt ttgtcagcgc gatattgacg 874501 gtatggggag gagcatttgg cgtcgacatg aatcaagagg tcggcggaac gagcgggtta 874561 acgatgattg cgggcataaa aacgctcgat accaacatca tcggagccat ctttatttct 874621 tcgattgtcg tctttttgca taatcgctat tttgataaaa aactgcccga ttttctcggc 874681 atctttcaag gctcaacata tatcgtgatg atttccttct ttattatgat cccaattgcg 874741 ttggctgtgt cttatatttg gccgatggtt caatcgggaa tcggctcgct tcaaagcttc 874801 ctggttgctt ctggggcggt gggcgtttgg atatacacgt ttttggaacg gattttaatt 874861 ccgaccggcc ttcatcactt tatttacacg ccgtttattt atggcccggc tgtagcggaa 874921 ggcgggatcg tcacgtattg ggcacagcat ctcggcgaat attcgcaaag cgccaaaccg 874981 ctgaaggagc tctttccgca aggcggattc gcgcttcacg gcaactcgaa aatcttcggt 875041 attccgggta tcgccctggc tttttatgtg acagccaaaa aggaaaagaa aaaactcgtc 875101 gcagggctgc tgattcctgt cacactgaca gcgattgtcg ccggtattac agagccgatt 875161 gagtttacgt tcttattcat ttcacctttc ttatttgcgg ttcacgccgt gcttgccgcc 875221 acaatgtcga cagttatgta tatggccggc gtcgtcggaa atatgggagg cggactgatt 875281 gaggcggtaa ccttgaactg gattccgctc tttggcagcc acggtatgac atatgtgtat 875341 caaattttga tcgggctctc gtttacagca atttattttt tcgtcttcag atttttaatc 875401 ctcaaattca atatcgctac accaggacgg gaaaaggatg aacagcagga aacaaagcta 875461 tattcgaaaa aggaatacag agaacgaaaa aacaaggatg aaacggcctc cgctgctgaa 875521 acggctgatg acaccgcttt tctgtatatt gaagcgctgg gcggaaaaga caacatcact 875581 gaagtcacaa actgcgccac ccgcctcaga gtcagtgtca aggatgaaac aaaggttgaa 875641 cccgacagcg tattccgcgc gcttggcgca cacggcgttg tcaggaacgg gaaggcgttt 875701 caggtaatta tcggattaag cgtgccgcag atgcgggagc gtgtggaaaa aatattgaat 875761 caataaagac tgccctcctt ttcgggaggg ttttcgtttg ccgtcaaaaa gaccgccata 875821 gtaaagtaaa gaaagagaca atcgagtaaa aaggggtttg gaggctttta catgcaaaag 875881 gctttgtcgt ttttaaaacc atattcattg ctggcgggaa ttgctctgat tcttatgctg 875941 acggagcttg cagttgaact gatgcagcct ttattgattg caaaaatcat cgacgatggg 876001 atattgaagc aagatctgcg gcatgtatgg atatggggca cggtcatgat cgggctgacc 876061 gtgttatcct ttgcggcggg gatgctgaat tccttttatg ccgcccatgt cagccaaagc 876121 ttttcctatg atacgagaaa agggcttttt caaaaaatcc agtccttctc ctattccaca 876181 tttggacagt tttcgtcctc ttcttatatt acaaggctga caaacgacgt cacacaggtt 876241 caaaatatga tttttatgag tttgcggttt atgctgcggg ctcccttaat gattgcaggc 876301 ggcattgtgc tgtcgcttgc cgttaatgtg aaactcgggt tttttctgct tgtgaccatt 876361 ccgatcctga tcttgttttt gctatgggta ttaaggaaag gcggggcact gttccgctca 876421 gtgcagaaaa ggctggatca agtgaacacc atcatgcagg aaaatttaat tgcaatcaag 876481 ctgatcaaag cgctgcttcg cggcagccac gaagtcaaac gatttatcaa agccaacaca 876541 aggctgatgg aaaaaacggt ttcggccttt cagcttgtgg aattcacgat gcctgtactg 876601 atgctgctga tgaatctctg catccttttg attttgtggg cggggtccta cagtattacg 876661 agcggaagca ctcaggttgg cgatgttgtt gcgataatta actacgcaac acgaattaca 876721 ggcgcgcttt cgatgtttcc gtttttgatt atgattttca cccgggcgaa ggcttcaggg 876781 gatagaatcg gtgaggtgct tgaaacagaa ggcgacgagc gggaggaagg caccatatct 876841 gatcgtttgt caggacggat tgagtttcag catgtatcct ttcgctatcc tgaaatggac 876901 agagaagcgc tcaggaatgt ctcattttcc gcaaagccaa gagaaacgat cgcgattctc 876961 ggtgcgacgg gctcgggcaa gtccacgctt tttcagctca ttccgcggct ttatcagccg 877021 gattcaggcc gcatttacat agatgaaaag ccggttcaag atattccggc tgaagggctg 877081 cgcaggcaaa ttggatatgt accgcaggaa gtcctcttgt tttccggcac aatcaaagaa 877141 aacatcgctt ggggcaaaga aaatgcttca ctagatgaaa taatggatgc ggcaaaactt 877201 gcgcaaattc atgaaacgat tttaaagctc ccaaatggat atgacactgt tttggggcaa 877261 agaggcgtca acctgtccgg cggccaaaag cagcggattt ccattgcgcg ggcgctgatt 877321 cgaaaaccgg ctatccttct attagatgac agcacaagcg cgcttgatct gcaaacggag 877381 gcgaagctgc ttgaagcaat cagcacatac cattgcacaa ctttgatcat tacacaaaaa 877441 ataaccacgg cgatgaaagc tgatcagatt ttgctgcttg aggacggcga actgattgaa 877501 aaaggcactc acagtgagct gctttctgaa tctcagttat acaagcgcat ttacgagtca 877561 caattcggaa gggaggggag cgagtcatgc taaaagacat ccgcaagcct ttccaatatc 877621 ccaaactgcc aattgacaaa aaagaaggcg cgaaaaagcg ggcgaaagca aaggatacaa 877681 agggcacact gagacgaatc tggtcttact tggctgaaag aaaaggactg ctcatacttg 877741 tcatgctaat ggttgtcatc agcgccatat tcggactcct tggtcccttt gtgatcggaa 877801 aggccatcga ccattttatc gtcgggaaaa cggtcagcgg cttgattcct gttttgcttc 877861 ttctgctcgc tatctatatc attcagtccc tgtcgctttg gtttcaaaac tattggatga 877921 ttacgatctc gcagggcacg gttttcagaa tgagaagcga attgttcacc catctgcatg 877981 agctgccgat tccatttttt gataaacagc ggcacggcga gctgatgagc cgggtgacga 878041 atgacatcga aaatgtcagt tctaccttaa acacgtcagt cattcaaatt ttgtcaagtg 878101 tgatcacctt tgtcgggacg attgcggtga tgctgtacat gagcccgctc cttactttga 878161 ttacgctgac cattattccg gtgatggcag cgagcctgaa atggatcacc aaccgaacgg 878221 gaaagctgtt taaagaacag cagaaaaacc ttggtgatct gaatgggtat attgaggaat 878281 ctgtttcagg cgcaaaggtc atcaaagcat attcacgtga gaagcagatt actgctgaat 878341 tcctcgaaaa aaacgctgca ctcaagacgt cgggcttttg ggcgcagacg atttccgggt 878401 ttattccgaa ggtcatgaac tctttgaata acttaagctt tacaatgatt gcggcaatcg 878461 gcggtttgtt tgcgctgaaa ggctggatct cgatcggctc catcgttgtc tttgccgagt 878521 attcaagaca atttacacgc cctttaaacg atctggccaa ccagtttaat acgatgctgt 878581 ccgcaatcgc cggcgctgaa cgggtgtttg acgtgcttga tgaaaaagaa gagcgcgagg 878641 atgaaaagaa cgccgtgcat cagcccatcc aaacaggcag cattgaattc cgggatgtgt 878701 ccttcggtta cgataaaggg cagcagacac tgaagcattt acagtttacc gtgcctgcgg 878761 ggcagtccat cgcgtttgta ggaccgacgg gggcggggaa gacaaccgtc actaaccttc 878821 tcgcccgttt ttacgagcct aacgatggaa aaattttaat cgatggtaca gatattaaaa 878881 cccttactag agcaagccta agaaaaaaca tggggtttgt tcttcaggat tctttcttat 878941 ttcagggaac gatcagagaa aacattcgct acggcaggct tgatgcttct gatcaggaag 879001 tcgaagccgc tgcaaaaaca gcgaatgccc atagttttat tgaaaggctg ccaaaagggt 879061 atgacaccgt actgacgcaa aacggttcgg gcatcagtca agggcagaag cagttgattt 879121 ctatagcgag ggcggtgctt gccgatccgg ttcttctcat tttggatgaa gcgacaagca 879181 acattgatac cgttacagaa gtcaacattc aagaagcgct cgcccgttta atggaaggaa 879241 gaacaagcgt catcattgcc cacaggctga acaccattca aagagcggac cagattgtgg 879301 tgctaaaaaa cggtgaaatg attgaaaaag gcagccatga cgagctgatt cggcaaaaag 879361 gattttacag tgacttatat gaaagccaat ttgagaaata gacctttgtc ctgcacagag 879421 gtcttttttt gttacagttt tatagtactt ttatttcatt ttcgtaaaat gtaacaaaat 879481 tacttgacgt aaacaagtta tgtatatata ctagcttaca ttaagtaagt gataacattt 879541 atcaaggagg ataaaatgaa taaatcattt gaaattggca cattactttt aagagttatt 879601 acaggtatta tcttttttgt tcacggttta tcaaagtttc agggaatgga gggcaccatc 879661 caatttttcg gcagcatagg ccttccaagc tttatggcgt atgtcatcgc agcgattgaa 879721 ctgattggcg gagtgcttgt cttcttcgga ttggctacac gtattgtcgg tgtactgttc 879781 gctcttacac tgatcggcgc catcatcact gttaagctga aagcgccatt catgggcaat 879841 gcagaatttg attaccttct gcttttgaca tccattcacc tggcgcttac tggaagtcga 879901 ttcctggcgc tggacccatt tgtgtttaaa ggaaaaaaga acggaaacgt ttcagcataa 879961 gaaaagaggc atgcagcatg accagcattc atgaggatac acacattggc tatgccaaac 880021 tcacaattcg cagtctggag cgttcgcttc agttctactg taacgtcatc ggttttcaag 880081 tcttaaaaaa gacggaccgc caagcggaat taacggctga cgggaaacgc gtactgctta 880141 ttcttgaaga aaatccgagc gctgtcgtct tgcctgaacg gtctgtgaca ggcctttatc 880201 actttgcgat tcttcttccg gacaggaaag aacttgggat cgcgctcgcc cgcctgattg 880261 aacacggcat tgctatcgga catggagacc atgctgtcag cgaagcgctc tacctgtctg 880321 atcctgacgg aaacggcatt gaaatgtacg ctgaccgccc ccgcagcacg tggcagcgtg 880381 atcgggaagg aaactacgtc atgacgacaa ccgctgttga cattgagggc cttctggaag 880441 aggcaggaga tgagcggaaa acatcgcttc cgaacgatac aatcatcgga cacattcatc 880501 tgcatgtcag tgatttgaaa gaagcaaagg cgttttatac agatgtactg ggctttgaca 880561 ttgtcggaaa ctatgcgggc atgtccgccc tcttcgtttc agccgggggg taccaccatc 880621 atatcggctt aaacatttgg gcgggaagaa atgcgccgcc taaaccgaca aatgccagcg 880681 gactagatta ttatactgtt gtcctgcccc accaagagga gctggatttg gtggcaaacc 880741 gagtcaaaca tgccgggtat tcgattgaag agacggaaaa cagctttcgt gtgaaagacc 880801 ctgtttccgg cgcctatatt acatttgtga tttaactgca atccccttgc cgaaataacg 880861 gcagggggat tttttatttt tgtccgcctt gttatgatga gagaaccaac ttgttaggag 880921 gcgtttacat ggaactcaac caccttgtga cgggcaaaat agcattaaat caatatgtgc 880981 atcgcttaga gcaaaaggat gtttcatttt acgtccacta ctggggagcg atgacgaacc 881041 actataacac actgcttcat aagcattcct tttatgaaat ttgttacgtg gtaagaggtg 881101 aaggatatta ccttgaaggc gatcgtacat atccgcttcg tgaacagacg atttttttgt 881161 caaagccgga gcatttgcac caaatcaaaa gtgaaacagg gctgttcctt ttttacgtcg 881221 ctttcgagct gagcgaggat cagtcaagcg ccgaatggat caaagtgatg gaagaagtga 881281 aacaaagccc ctttatcaca atgcaattga aagatggcga accgccgggc ctgctttgga 881341 aaacgttaat gctgcaagca gcgcaacctg tcaatgcttt tgacaaagag atcctatctc 881401 atttgtcgca tgcattgatc ctgtcattaa tccaaacctt tctcccgtac gcccaacgcc 881461 cgaaacaaaa gcagcccatt cacacatctt ctgctttgct gacagaggtg aaactgcaca 881521 taaaagacaa tctgtcacag ccgttaaagc tgacggatgt cgctagccac tttcatatct 881581 cagggaggca tttatcacgt ttatttgcag cagaactggg cgtcagctac tcagaatttg 881641 tccaaaatga aaaaataaac aaagctgccg aactgctgaa atcaacgaat ttgtcgatta 881701 aagaaatagc ggaagaaatc ggtttctcag tacattattt cactcgcgtc ttttccgcta 881761 aaatcggcag ctctccaggg cttttccgct ccctttataa agactcaaaa atgaccgcat 881821 ttcaaatcaa taaacctttt caaaaaatcg aacaggccaa gccgcacgaa taagatgtcc 881881 tgaaatgaca aaacaatgtc ttcatatgat aaagacgcga gaaatctcgt tgtcttataa 881941 tctttttaga aagcggttac aacaaggggt attgctgaag gagggatgca ttggcttatg 882001 cttggtgtcg ggtgctctgc cattcttgaa agaaggggaa gaaagccgtg agtacaaaaa 882061 agaaagaggc tgtaatagga aaagaaagct tagctcataa agggctttta cgaacgatta 882121 cattggtatc tacattcggc ggcctgttgt tcggttatga tacgggtgtc attaatgggg 882181 cacttccttt tatggcaact gcaggtcagc tgaatcttac acctgttaca gaaggactgg 882241 ttgcgagttc cctgcttctc ggggcagcct tcggggcgat gtttggagga cgtctgtccg 882301 atcggcacgg ccgccgaaaa acgatccttt atttagcctt actcttcatc gcagccacac 882361 ttggctgtac cttttcacca aacgcgtccg tgatgattgc ctttcgtttt ctgcttggac 882421 tggcggttgg ctgcgcttct gtaacggttc caaccttttt agcggaaatt tcgccggcag 882481 aacgcagggg acgaatcgtg acacaaaatg aactgatgat cgtaattggc cagcttctgg 882541 catacacctt taacgccatt attggcagca caatggggga gagcgcaaat gtatggcggt 882601 atatgctggt catcgcgaca cttccggctg ttgtgttatg gttcggaatg ctcatcgtgc 882661 ctgaaagccc gcgctggctg gcagctaaag gcagaatggg tgacgccctg cgggtgcttc 882721 ggcaaatccg tgaagacagt caggcacagc aggaaataaa agaaatcaaa catgcgattg 882781 agggcacagc aaaaaaggcc ggctttcatg attttcaaga gccgtggata aggcgcattc 882841 tattcattgg gattggaatc gccatcgtac agcaaattac cggtgtcaat tcgattatgt 882901 actatgggac agaaattctg agagaagccg gttttcaaac agaagctgca ttaatcggca 882961 atattgcaaa cggtgttatt tcagttattg cggtcatttt tgggatatgg cttctcggca 883021 aagtccgtcg ccggcccatg ctgatcatcg gacagattgg cacgatgaca gcccttctgc 883081 tgatcgggat tttatccatt gtccttgaag gaacacccgc cctgccgtat gttgtgctga 883141 gtttgaccat tttgtttctt gcgtttcagc agactgccat ttctacggtg acgtggctga 883201 tgctctcgga aatctttcct atgcatgtgc gggggcttgg catggggatc agcaccttct 883261 gcttgtggac agctaacttt ctcattggat tcacctttcc cattttgctc aatcatattg 883321 ggatgtcggc gacatttttt atctttgtcg ctatgaatat cctagcgatt ctatttgtga 883381 aaaaatatgt gcctgagaca aaagggcggt cacttgaaca gcttgagcat tcctttcgcc 883441 agtatggccg ccgcgctgat caggaaatcc aaaatcaaac aactcactta tcgtaacctg 883501 agataccagg aggaatctat caatgaaact atcttatgta acagacagcc tagggcattt 883561 gccttttgaa gacatgctca attttgccgc aaagcttggg atcgatacac ttgaaatgac 883621 aaccgggggc tggtcgccgg cacctcactt gaatcttgat gaattgctgc aaagcagcga 883681 aaaaagaaaa gaattttcac aagcgctgga aaagcggaac atgacacttt gcgcattaaa 883741 ctgctcgggg aaccctttag atccgggtga attgggcaaa tcgcacagag acataactga 883801 caaaacgatg gagctggctg gattattagg cgtcaaaaaa gtgatcatga tgagcggttt 883861 gccagccggc ggcccggacg acaaagtgcc gaactggatc acatacacag taagctggcc 883921 tcccgtttta aaagatatcc tcaactatca atgggaagac gttgcgatcc catattggaa 883981 gaagcttgtc aaaaaagcgg aggcctgcgg cgtggggaaa atagcgcttg agaacttcag 884041 ctctcaatta gtctataatc ctgagactct ctttcggctc agaaatgcag tcggcccgat 884101 ggtcggtttg aatcttgacc cgagccattt gttatggatg ggcgcagacc cgatcatcgc 884161 agcaagggag ctcggctcag ccattcacca tgtccatggg aaagatgtca gaattgaaag 884221 atatttatcg gcggtcaacg gacttttaga aacaaaagaa gtgacagatc ctgcaaaccg 884281 ggcgtggaat tacgtagctg tcggctgtgg acaggattta cagtggtgga aggaattttt 884341 ttcagttgta aaaatgatgg gatatgaagg tgaggtttct ttagaaatgg aggatctgac 884401 gatgtcacct gaagcgggca tccgtacttc tgtagaagct ttaaaacaaa ccatcagcca 884461 ataggaggtt ttcatgatgc taaatggaga aagaatcatc tctaagccgc ttcgctgggc 884521 aatggtaggc ggcgggcggc tcagccaggt tggatataaa catcgtattg gagcgctgag 884581 agacaatact gcttttcaat taactgctgg cgcttttgat atcgatgccg aaagaggaaa 884641 agatttcggg gtgaaccttg gagtggatgc ggaacgctgt tatcccaact atcaaaccat 884701 gtttgccgag gaagcgaaaa gacaggatgg catagaggta gtatcgattg ccactccgaa 884761 cggcactcat tatgagattt gtaaggcggc gcttgaagca ggagtgcatg tcatctgtga 884821 aaaaccgctg ttcttcactt cagcagaggg gcaggaaatc aaagcgctcg cagagaaaaa 884881 agggaaaatt gtcggcgtga cgtacggttt ttcaggcaat caaatgcttc ttcaaatgcg 884941 tgcgatgatt gaacaaggaa tgatcggcga tattcgcgtg gttgacttgc agtacacaca 885001 cggtttttgt gcaacagatg aaggtgaaaa gataagcgct gcacagaaat ggcgtgtcga 885061 ccctgcgatc gccgggccaa gctttgtgct gggcgattta tctacccaca cgtattatat 885121 gtcacagctt attatgccaa agatgaaaat taaggagctg ctgtgtgacc gacagagctt 885181 cgtcggcagc cgcgcaccgc tagaggataa tgcccatgtg ctgatgcatt atgaaaatgg 885241 agcggtcgga acgatgtgga catcgtcaat caatgccgga tgtatggatg gccatagaat 885301 ccggattgtc ggctcaaagg caagcattga gtggtgggac agcaagccaa atgaactgac 885361 gtatgaagtg cagggagagc cgggccagac actcgttcgc ggcatgccgt atttagatga 885421 tgtttgcaac gccgatgaac gactgggcgc cttacacagc gaagggctgt ccgaagcatg 885481 ggccaatatt tatcttaaat ttgccattgc gatagacgcc aaaaaccgtg aagatgaaga 885541 aatcttgaac aacttggttt atcctgacat tgatgcaggg atcgagggca ttcgctggat 885601 tgagaactgc gtgcgctcgg caaaccaagg gtcagtttgg gttgaattta aataaatgag 885661 ggaatgcgcc gcatatgaca taaagttcat atgcggtttt tattttccag aaactcctgt 885721 caaaaatgcc ctgaggcagg tatgataaga agggaattgg gtatcgggag tgatgagcgt 885781 gaaagctctt ttttttacga gaatgttcac cttgatggtg agctgtttaa tgtatctgtc 885841 cattgtgaaa gaggataact ggtttggata tgtatttata gcagcaggtg ctgccatgta 885901 tgcagccaat catgttttgc tgacaaaaga gacaaatgcc atctggttct gcctgattga 885961 tattgcaatc ggcttttcgt tcggatttat ctttcccggc acaggtttgt tcattattat 886021 gctttgtccg gttgcggtcg ccttttttct gcgggggttt cctaaaagaa cagcatggtc 886081 tgtcttatgt ctttcctcta ttttattttt gaccgtcctc atccgtacat atgcgatgtt 886141 cggcaatgaa tttgtcattg atcatttgac tagcatgaca ttcgttgtct tctgcggtgt 886201 cgtgggcaaa ttaatccgca agctgttgga tgcgcaggat acggcaaaac agcagtttca 886261 ggaactgacg gagtcccatc tggcgctgtc tgctgcacat caggagctcc atttatatgc 886321 gaagcaggtt gaagagctga ctgccattta cgagcggaac agaatggcgc gtgaaatcca 886381 tgatacagtg gggcataaaa tgacggccct tctcgtccag ctgcagcttt tgcgtgaatg 886441 gcaaaaaaga gacagccaaa aagcggatga gacagtaggt gtctgtgaaa cacttgcccg 886501 tgaagcgctt gatgatgtcc gcttatcagt acgcactctg caaactgaaa acgatccttc 886561 gctaatcgaa tcgctgaaac agctgacaga ggacttttgc aaaaatgcag gagtcacaac 886621 agaatttgcg gtcagcggtg atcctgcaat catcccgctg tctctccatc cgaccctgat 886681 cagaacggtg caggaagcac tgaccaatgc caaacggcac ggcggcgccg cagcctgttc 886741 gatacagctt gcctgcacaa cggacagcat cagccttgtc attaaggatg acggcaaagg 886801 caatcctgag gcagcacttg gttttggtct cttgaatatg aaaaagcggg cagcggagca 886861 tggcggaatg atccgctttg aaagcgaacg ggatcaagga tttactgtaa atgcagaatt 886921 ttcacttgcc aataaaaaat ggagcttcgg gcccgtgcag caaaaggaga gtttatcatg 886981 attaagatca tcattaccga cgatcaggat atcgtcagag aagggctggc atccctgctc 887041 cagctccgag aagagctcga tgtgatcgca acggcgcgaa acggacagga agccttcgaa 887101 aaggcgaaag agctggagcc ggatatcgtg ttaatggaca tccgcatgcc ggtttccaac 887161 ggggtggagg gaacaaaatt aatcacaagc tcgctgccaa gcgtaaaggt tttgatgctg 887221 acaaccttta aggattcagc gctgattgct gaagcgcttg aagagggagc aagcgggtat 887281 ctgctgaagg atatgtctgc agatacgatt gtaaaagcag tgatgactgt tcattctggc 887341 ggaatggtgc ttccgccgga attgactgcc caaatgctga atgaatggaa gcgtgaaaaa 887401 cagctgaaag gaataaatga gatagaaaaa cctaacgagc tgctcgacct gaccgagcgc 887461 gaaatcgaag ttctggctga gctgggatac gggctgaata acaaagaaat tgccgaaaag 887521 ctttacatta cagaaggcac agtcaaaaac cacgtttcaa atattatcag caagctggct 887581 gtcagggaca gaacccaagc cgccatttac tcggtcagat atggtgtatc tgtcttttga 887641 catatgacgt tttgcatata cgcttctctg aaaaggcctt ttacaggcct ttttttcatg 887701 ccctatgttc tatctgccgc tacatgccgc acgcctttct ttcttctaca atggcaatgg 887761 atcaaaaaaa ggagtgagac gacgtgctgc aagcagaaaa catcaaaaag gcatacggaa 887821 aaaaaacaat cgtgaaaggc atttcttttt ccctcaaaaa gggggagtcg ttcggtctgc 887881 tcgggcctaa cggtgcgggg aaatccacaa ccatctcgat gatttccggc cttgtgccgc 887941 atgacagcgg gaacatcacg gtgggcggct atgttatcgg aaaagaaacg gccaaagcga 888001 aacaaaaaat cggcattgtt ccgcaggaaa ttgcattata tccgacgctg acggctcatg 888061 agaatcttat gttttggggg aaaatgtacg gacttacgca cggtgaggcc aaaaaaagag 888121 cggctgaggt ccttgaatat gtcggtctga ctgagcgggc taaagataag attgaaacat 888181 tttccggggg gatgaaacga agaatcaaca tcggtgcggc tttaatgcat aagcccgagc 888241 tgctgattat ggatgaaccg actgtcggta ttgaccctca atcgagaaat cacattttag 888301 aaacggtcaa acagctcaac gaaacgggca tgacggtgat ctatacgagt cattacatgg 888361 aagaagttga gtttttatgc gaccggatcg ggataattga tcagggggaa atgattgcga 888421 ttggcacaaa aactgatttg tgcagccgcc ttgggggcga taccatcatt cagctcacgg 888481 tcagcgggat caatgaagcg tttcttgtgg cgatccgatc tctggcccat gtgaatgatg 888541 taacagtaca tgaattagag ctcaaaattg acatttctgc ggctcatcat gagaaagtcg 888601 tcacaagcct gcttgctgaa gccactgctc atcatataaa cctgctgtct cttcaggtgc 888661 aggaaccgaa tctggagcgc ctgtttctga atctgaccgg ccgcacgttg cgggattgag 888721 gagggacggc aatgaaaaaa agcatatgga tcgcatggaa agatgtgaaa atcagaatca 888781 cggacagaaa agggtttatg atgcttatcc taatgccgct catcctaacc tgtattttag 888841 gcgcagcgct cggatcagtt gttgacggag gcagccggat tgatgatatc aaagtcggct 888901 acattcaatc agaccagtca gatacagcaa acatgtttac aaaagatgtt ctcaaaaaaa 888961 tgaagtcgat aaaggtcaca aaagtcggca gcaaagacaa gatgaaaaaa ctgattgatg 889021 aaaagaaaat cgatgtaggc atcgttatcc cgaaccattg ggaagccggc aaaacctcag 889081 ctgttgttaa tgccgctcct gatcaaacat tgaaaagttc catcattgaa acagctgcaa 889141 gctcatttat agagcaatat aaagcggtaa aggaagccgc gtcaggctca atggactaca 889201 tcagtaaaac ggaagctgta aagcaaggaa aacttgaccc tgcacagttt gcagaaaagc 889261 tggcaaagac gctagaaaaa gaaacaggtg acaagcttac tattgcggaa aaatctgtcg 889321 gcagcaaagc cgttaccagt tttcaatact attcggcggc aatgctttgc atgtttatgc 889381 tgtttcatat cacagtcggg gcgaaatcat ttttacagga aaaggatacg gagacgcttg 889441 ccagaatgct gatgacgcct gcgcaaaaat ccgtcattct cttcggaaaa tggcttggga 889501 cgtatctgtt tgccatcata caatttttca tatttctgat cgtcacaatc aacgtatttg 889561 gtgtggactg gggcggtaat ctgctgttag tgagtgtact cgggctttct tacgccgcag 889621 ctgtatctgg tatttcaatg ctgcttgcgt cgtgcatcag cgatatgaaa actgcagatg 889681 cgataggcgg cttcggcatt caattgcttg cggttctcgg cgggtccatg ctgccgctgt 889741 accaatttcc ggacgtcttg cagtctgtat ccaaagcggt gccaaatcgc tgggcgcttg 889801 acggctttct ttctttaatg gaagggggag gctgggctga ccttcaaaag cctgtgcttc 889861 tttttgcggc gatcggcttt tgttcacttg taattggtat cagacggctt catacaagat 889921 aaggaggtac aaaaggtgaa aaaaattcta gccatttgcg gcattgagct ttctctcatt 889981 tttaagaagc cacagaacta tttgatcatg tttgctgccc cgcttttgct tacctttgta 890041 tttgggagta tgctcagcgg caatgatgat aaggtgcggc ttgcaatcgt tgatcaggac 890101 gatacgattc tctcacagca ttatattcgg cagctgaagg cacacgatga tatgtatgta 890161 ttcgaaaaca tgtctgaaag caaagcgtca gaaaagctga aacaaaagaa aattgccggg 890221 atcatcgtca tttcccgctc gttccagaca cagctggaaa aaggcaaaca tcctgagctg 890281 attttccgtc acggccctga gctgtcggaa gcgccgatgg tcaaacaata tgcagaaagc 890341 gcattggcaa cgctcaatat tcaggtgacc gcggcaaaaa cggcatctca gacagcggga 890401 gagaactgga aggcggcgta taaaacggtt ttcgccaaaa aacatgaaga tatagttccg 890461 gctgtaacac gacagacgct cagtgataaa aaagagggtg cggaagcaag tgacacagcc 890521 tccagagcag cagggttttc catcctgttt gtcatgctga ccatgatggg agcggctgga 890581 accattttag aagcaagaaa aaacggcgta tggtccagat tgcttacagc ctctgtcagc 890641 cgagccgaaa tcggtgctgg gtatgtgctg tccttctttg tcattggctg gattcaattt 890701 ggaatattgc ttctttccac ccattggctg tttggcatca actgggggaa tccggctgca 890761 gttattgtat tagtgtcact ttttctattg accgttgtcg gcattggatt gatgattgcg 890821 gccaacgtca gaacgccaga acagcagctt gcgttcggca acttgtttgt catcgcaaca 890881 tgtatggtga gcgggatgta ttggccgatc gacattgaac cgaaatttat gcaatccatc 890941 gctgaatttc ttccgcaaaa gtgggcgatg agcgggttga cagagattat cgctaacggt 891001 gcccgcgtca cagatattct cggaatctgc ggcattttgc ttgcatttgc tgcgatcact 891061 ttcgcagcgg ggctgaaagc gctccgagcc taaaaaacat ctgccgttta ggcagatgtt 891121 tttttgcatg tgggtacatt cgtatgggtg cagcctgaac tgcggttaat ccttatctat 891181 catagctaaa attgattcca gccaagaaac gtaatttttc tcccgctcca gcgctttcgt 891241 tagcacaaga tagtggccga agtccggtga agaaaatgac atcggctctg ctgaagccat 891301 aagcttttca tagcttccct gtaagtcaga aagcttggcc tggcgttttt gcagctggtc 891361 tttgaacaaa tcagaagcct cctggcgcga tagacaagaa atgaaataag ccttcagcat 891421 aaattcatcc ttcaccgtct cgggtatcgg ctggtggcgg atcagccagt catgcagctc 891481 ctgctttccg ctgtctgtca gggtgtacat ctttttctcc agctttgtgc cctgaatcgt 891541 tgtccggaac gtgataaatc cttcatccgt cagctttttg agctcagggt aaatctggct 891601 gtgcttggcg ctccaaaact ggccgagctc ctctttaaaa taactcgtaa tatcgtatcc 891661 actcaattcg ccttttcgca aaagccctaa tatggcgtat tttaatactc tcatgctatc 891721 ctccgtgtct ggctgtttcg caaaacagat gagccggtgc tcaactgtga ttctaactgc 891781 ctattcccct tattatagaa aagggaggaa gggaacacaa ccgggctctt tggaaatgaa 891841 gataaaaggt ttgtcagaag gtatccgatt tatctccgtc aatataaaag agatttaaat 891901 ttaattttca gaaaaaatag taacgatatt gattttttat atataatagg aaattggtgg 891961 tatgaaaatt ttttggggga ataaacgtga aaaaagtact tatggcattc attatttgtt 892021 tatcgctgat tctatctgtt ttagccgctc cgccgtctgg cgcaaaagct gagtcagtac 892081 ataatcctgt cgttcttgtt catggaataa gtggtgcatc atacaacttt ttcgctatta 892141 aaaactactt aatttctcaa ggctggcaaa gcaacaaact gtacgcaatt gatttttatg 892201 ataaaacagg aaacaaccta aataacggcc cgcagcttgc ttcatatgtt gaccgtgttt 892261 taaaagagac tggggcaaaa aaagtagata ttgtggctca tagtatggga ggcgccaata 892321 cgctgtacta tattaaatat ttaggcgggg gcaataagat tcaaaatgtc gtaacgcttg 892381 gaggggctaa tggtttagtg tcatcaaccg cgctgccggg cacagaccct aatcaaaaga 892441 tcctctatac atctatttac agtctcaatg atcaaattgt catcaatagc ttgtctcggt 892501 tacaaggagc gcgaaacatc cagctttatg gcatcggtca tattggcttg ctttctaata 892561 gccaagtgaa cggctatatc aaagaagggc tgaatggcgg aggcctcaat acaaattaat 892621 atcttcaaaa aacaacctgc tgtctccgtt acagtgggtt ttttcgtctg agaaagccat 892681 agggtcttat gaccttagtc tatcatgcat acgtcaattt atgacatcag gcactttttc 892741 aaatagagcg gacatgttaa ggtacaacca tcgatttcta tcaatttgaa ataaaaggag 892801 cgctgttatg caaattaaag aaatttttat gatccgctgc atttcgtgct taagtgtcgt 892861 cttgctccat atcatttcaa tggtcctgat gcttcaggca gaagctcttg cagatatttc 892921 tcacactgtt gattctttcc gcacactcct gatgttcagc acgcccgctt ttattttcat 892981 ctctgaattt ttactggccc gttcttatcc tgatggggtg cctgacggtt ttttaaagaa 893041 gcggggaaaa gtgatttttg ttcctttttt atttatcgca gccatcgatg cgctgctgat 893101 gaccagtgcg atggggggag aggtaacctt tctcgcgttt gtgcaaaaat atctggcgaa 893161 cgtattctta ggaaacttta tcggatactt cattctcgtc atctttcaat tttacatgct 893221 gcatatgatg tttcatgagt atttgaaaaa agcatcgccg aaatgggtgc tgtctatctc 893281 atttgtggtg acagccgctt atttaggcta tttctccgca gccagcccgg ctcctgcttc 893341 tgaagaggga ggggcatttc cgttcttctg ggttccgttc gcaggctggc ttttctactt 893401 ttgtctagcc tactattgcg gaaaagaata caagcgtttt ttagcgctgc tgaaccaata 893461 ccgctgggtg gtgtacggcg ccgcaattgc ttctggggcg ctggttgtca ctgtttctta 893521 tgtcggtgaa atcggcatga tcagctcgaa gcggcctgat atcatgctgt attcaacaag 893581 catgattttc ctgtgttttc atttgttttc caaaatgaag catgtgccga aaatcatgat 893641 gtttatcagc aactattcct tttcgattta tctgcttcat gcctatttta tgattatagg 893701 ctacgtgttg cttttgaata tgcccgaaat tcctgccgta ccggctgttc tcctgttgtt 893761 tgccgtgtgc acagccggcc cgattatgac ctcatgggcg ctgaataagt tcaaatacgg 893821 gtatttattt gtggggaaaa tttatcagcc aaaacagaag aaggtaacag tcgaagtgcg 893881 tgatcacgca gggtgaaaaa caagcggcag gagggctcct gccgcgtttc tttacttctc 893941 atccgcttgc agaactgttt ttaaatatag ttttgcagac tcagcaagtc cagatacatc 894001 agccttttct tcatcgaaat acagggcgtt ttgaatgatg ccgtcattca tattgaggaa 894061 aaacttggcg atagtcgcaa gaggctgaac cggctgaaac tctccctgat cgatcccttt 894121 ttgcaatagc cttgaaaacc tttccacaaa aagatcatac cttttctcca aatactgccg 894181 ccgttcttca ttgcgccaag ctgtcactaa atattcaaat tgcaccggcg ccagcgtatc 894241 tgctacatct cgcaggccct cagtcagttc atccaaatag ctggaaatgg aggcccaaac 894301 actttggtgt tcagctgatt tatcaagctt tcggagtcct tcatccagcc ctgtttcaat 894361 aatgcggcga aacatctcct cagtgcttga aaaataaaga tagacaccgc cccggctgaa 894421 acctgactct tctacaacat ccttcatcgt cgttaattcg aatccttttc gtttaaaaac 894481 cgttttggca gcctctaaaa tctctgcctg ccgtttatcc ttgtgctcct ttgttacttt 894541 tggtgacaag atatcgcctg ctttctgcaa ttttcttacc tataagtgta atcaacccaa 894601 tcatgatcag caagcagcca cagacaagaa aagcaagtga tacaccgatc cattccgcca 894661 gcacgccccc gcccgccatg ccgaggatag aggcgagggt tgtcgcactc tgaatagcgc 894721 cgaacaccct accgctgtaa tcgacaggca ctgttgtttg cacgagaatc tgaaatggaa 894781 tatggacgag gccgaaagcc gcccccatga tgaaaaaagc aaatataaag agagtgatgc 894841 cggcaattcc cataccgctt aggaatggcg cacctccagt tgctagtcca agaagaaggg 894901 ttccagctga gaaataaagc aaataagaag tgattcgccg tctgccggta atggccgctg 894961 taaggagcat cccggctccg cttacggcca tgcaccagcc tgccagctcg ggcggagctc 895021 ctgaaaagga gcggataaga ataatcgctt gggaatcacc aatctgcaaa acaaagagaa 895081 cgacacaagc tgttagtaag cctgttaata gaagcggcat ccgtttcaaa aactgaaggc 895141 cttccttgat agaagtaagt gctgctgttt tttcttgagg tgtattggct ttttgtaaaa 895201 aagcatctct gggaaggaaa aacaaaatga cagcggaaag aaagaaggcg ccggcgttta 895261 tataaaaaac agagtgtatc gagaaagcag cgatcagcgt gccgccaagg gcagggccga 895321 agatttttga gctgttatca atgatgctgc tgacggaaac ggcctgctga atgtgtgctt 895381 ccggagccaa ttccttaagc tttccgtttt tagcaggtaa aaaaagtgaa gaaaaacagc 895441 tctgaacgga tagcaatacg taaagctgcc aaagctcact gacataaacg cagctgataa 895501 cagtgagggc acggccgatt tcagatagaa acatgatcgt ttttctgtca aaacggtcgg 895561 caagcagacc cgatacaggt ccgagtacaa tgacaggcaa agcaaacgac atcattaaaa 895621 gcgacatatc taatggagaa gcatgaagct gaaaagcggc taatgttagc acggccaaaa 895681 tgtgaagcca gtctccaagt gaagaaatgg tttgcgaggc taacagtgtc atcagtcctt 895741 tttgattgcg aaacaacggt ttttccatga ttcatcctcc tgattattaa aatgacacta 895801 gtgtcgtttt taattgtatg ggaaaaagac acaatataca atctttttct tgtaaaataa 895861 aggagaagat tgaatagaag ggagaacatt catgacatca gtcaatctaa gctacccaat 895921 aggagaatac aagccgaggg aatccatatc gaaggagcaa aaagataaat ggattcaagt 895981 acttgaagaa gtgccggcaa aattgaagca agctgtagag gtcatgacgg acagccagct 896041 tgacacaccg taccgggacg gtggatggac cgttcggcaa gttgttcatc atctggctga 896101 cagtcatatg aacagctata ttcgttttaa attgagcttg acggaagaga caccggctat 896161 ccgtccgtat gatgaaaaag catggtcgga gctaaaagac tcgaaaacgg cagatccgag 896221 cggctcactc gcgcttttgc aggagcttca cggaagatgg acggctctgc tccgcaccct 896281 gacggatcag caatttaagc gcggatttta tcaccctgat acaaaggaga tcattaccct 896341 ggagaacgcg ctcggcctgt atgtctggca ctcacatcac catatcgctc atattacgga 896401 gctttccaga cggatggggt ggtcttaacg cttttgccgg cggaaagccg gaatactgat 896461 agcagcaatc accagaagtg agaccacagc agccgctgca tataaatgat catagccgct 896521 ggcgacactc gcatgaatgg cgtcgcttat cgcggttttg acttcaggaa cgggaatgcg 896581 ttcgatttgt tcttgtaaag aagaaacttc agaactgtcg atctccggaa tcatctgcat 896641 cgccttttct gaatatccgc tgtccgataa gcggctgttg atctcatcac ctatttggtc 896701 aaacccggct gtgataaaac ctgcataaag agtaggcgcc aaggtcagtc caatttgcct 896761 tactaatgaa agcgtgccaa gagctgtacc cttatttgtt tttgccgctt ctgatacaag 896821 gacgttcagc ggagcgccta acagaaagcc aaaaccgatc ccagctgcca cacttgcgat 896881 cacaaactcc catttttccg tgacccagag cggaaataaa gcaaaccccg cacatgagat 896941 gattcccgaa agaataacgg tttttacagg accttttttg tcggtaagtg ctccgccaag 897001 ccaagcgccg attccggaag ccaacgcaag cggtgtcatc caatagcctg cttttgcggc 897061 agggacaccc aaatactgtt cgacatatga cgggataaaa atgactgccg ccaagagccc 897121 cccggataac aaaccgatga taagcgtgcg ctgaaacata tggtttcgca gcagagaata 897181 cgccaaaatg ggatcgcctc ctcgcatttc aactctcttt tcatacgaga taagcgctgc 897241 aaaacagagt atgccaaaaa taatacatcc ataaacctcc ggattcccca agctgtgtaa 897301 gagatttgcc ccgtcaagat tggtcatgcc gtacatcaca gctaaaatcg acagggacaa 897361 aaggaagatt ccggccgcat cgaggcgctt agcctcaggt gcttttgttt ccgcgataaa 897421 acatgcgccg aaaacaacca atagcacggc aatcggcaaa ttaatcaaaa atagccaatg 897481 ccaagacccg gtccaatcaa gcagaaagct tccgatattt ggcccgagca cagcggccat 897541 cccgttcatt gcgccaagca gcccaagcgc cttcccctgt ttttcctttg gaagggtcgc 897601 gagaatgtga gagctgccga tgatgaaaat cccgccgcct ccaagcgcct gaatcagccg 897661 cgatatcaga aagagcggga agctttggct caaagcaaca agcaaagaac caagtccgaa 897721 caggcaaacc tcaatgagaa agagtttttt tctgccgtag cggtcggaaa gttttccgac 897781 gattggcaca ctgacgctaa gaccgagcgt ataaagggta atgccccatg atccccagga 897841 aggggaaacg gaaaacgact cgtttatcgt tgttaaagca gccgaaataa ttccgttatc 897901 taaagcagcc ataaacacgc caatcgtaaa caggctgatt gcccactttt ggcttttctg 897961 ctctgttaat gcttcagaca ttttcgtcaa ctccttttag ttcacttgaa atatattatt 898021 cattttaaat gaactaaatg tcaaataaaa aaagcctgct cccgcagttt gcggatgaca 898081 gacttactga tttattcttt tttcgcattc tctaatgctc ttgaaaggat agacagccct 898141 tcgtaaacag cctgcttttc ttcaggggac agcagctcta atgaacgctt caatttcagg 898201 tggccctttt catacaaacc ccggaaaatc tttttcgcat tctctgtcaa ctgaacaact 898261 acagagcggc ggtcctcttc agaatgtgag cgtttgacaa atcctgattt ttcaagccgg 898321 tcaagcagcc cagttgtatt ggacagggaa gcccccattt tttcagcaat gtcgctcact 898381 ttcaatgttc catggttgtt taatagcatc agcaccttca tttgcggcat gctcatatcc 898441 agtttcatcc actcggacac atcaccgagc ccggcggacg ttaagacttt catatagagc 898501 acccatattt cccgttcctc cgatgaaaga atgttttcgt ttaagactgt tgtatcgtgt 898561 aaattatatt ccatttcatc acttcctcat cattcactcc tcttaccata ttactcgatt 898621 ttcactcctg aaagaaagtg agcagaaacc gcatgcggga ctttgtccga aaaataacgg 898681 tagtgtataa tgagttggag attattgggg gagaggatcg aactagaata tgattggaga 898741 gaccattgct gattaaaaag aatgctttat caatattaaa aatcgttttt cctattgctg 898801 ttttgctatt tgttatttat caatcgaaaa aagaactgac aaatctgtca ttcaaacgta 898861 cgctcatggt catcaacgga ctggaacgaa cggatttatt catgcttgtg ttgatcggct 898921 tgctggctgt tgcggctatg tcgctgtatg attacgtcct gaagtactca ctgcgcctat 898981 cgatcacaaa cggaaaagtt ttcagggttt cctggatcgc caattcattt aataatgtgt 899041 tgggattcgg cggtttagcc ggagtcgggt taagaatgat gttctataag gagcatacga 899101 aagaccataa ggcactcgtg aaaggaatcg cctggctcac atcatctatg ctgctcggat 899161 tatctgtttt cagcattttc gttgctgcga gagtgctgcc agttgatgaa gtgattcatg 899221 agaagccttg gctgtgggcg gtcgttatcg gttttgcact gatattgccg ttatctttag 899281 cggtgtccaa aataaaagac cgcaaagctg gggacgaaga gaatgcggat aaagtgaaaa 899341 atccgatttt cgcatatatt ggagcttcag ttgttgaatg gctcatggcc gggaccgtca 899401 tctattttgc tttgttcgct atgggcattc atgcagatat caggtatgtg ttcggggtgt 899461 tcgtcattgc ggcgatcgga ggaatgatca gcctcgtgcc gggcggcttc ggctcgtttg 899521 accttttatt tttgctgggg atggagcagc ttggctatca tcaagaggcc atcgttactt 899581 ctattgtgtt gtacaggctc gcctactcat ttatcccatt tatcttggga ctgttctttg 899641 ccgccggcga cctgacggaa aatacaatga agcggctcga aacgaacccg cgcatcgcac 899701 cggcaattga gacgacaaac gttctgcttg ttgttcagcg tgcggtatta gtgagaattt 899761 tgcaaggctc gctttccctt attgtgttcg tagcaggtct gattgtcttg gcctcagttt 899821 ccttgccgat tgacaggctg acggttatac cgcacattcc gcgcccggcg cttttgctgt 899881 tcaacggcct gtccttaagc tcagcgctca ttctgctcat tttgccgatc gagctttata 899941 aacggacaaa acgttcctac acgatggcca ttacagcgct tgtcggcggc tttgtgttca 900001 gctttttaaa agggcttaac atcagcgcga tattcgtact gccgatgatt atcgtattgc 900061 ttgtgctatt gaaaaaacaa tttgtccgcg aacaggcatc ctatacactg ggacaattga 900121 tattcgctgt ggcgctgttt actgtggcgc tctttaacta caatctgatc gcgggcttta 900181 tttgggaccg gatgaagaag gtgctgcgtc acgaatattt cgtccacagc acctcgcata 900241 ttacacatgc aaccatcatg gcgatcatca ttgtgccgct gttcttcttg atatttacag 900301 tggtctatca taagagaacg aaaccgatcg gagagaaagc tgaccctgag cgtcttgctg 900361 cgtttctcaa tgaaaaaggc ggcaacgcgc tgagccatct tggttttctt ggagataagc 900421 ggttttattt ttctagcgat ggaaatgcac tgcttctgtt tgggaaaatc gccagaaggc 900481 tggtcgtgct cggcgatcca tctggccaaa gagaatcatt cccgctcgtg ctggaagaat 900541 ttctgaacga agcgcatcag aagggattca gtgttttgtt ctatcaaatt gaacgagagg 900601 acatggcgct gtatcacgat tttggctaca acttctttaa attgggtgag gaagcatatg 900661 tagatttaaa tacatttacc ttgactggga agaaaaaagc cggccttcgg gcaatcaata 900721 accgctttga gcgggaggag tatactttcc atgtggatca tcccccattt tctgatgcgt 900781 ttttggagga gctgaagcaa atctcagacg aatggctcgg ctcgaaaaaa gagaagggat 900841 tctcgctcgg attttttgat ccttcctatt tacagaaagc gccgatcgcc tatatgaaaa 900901 atgcagaagg agagatcgtt gcattcgcaa atgtcatgcc gatgtaccag gaaggagaga 900961 tatcggtcga tctgatgcgc tatcgcggcg acgctccaaa tggcattatg gacgcattgt 901021 ttatccgtat gtttttatgg gcaaaggaag agggctgtac gtcatttaat atggggatgg 901081 cacccttggc caatgtcggc actgccttta catccttctg gtccgaaagg tttgccgctg 901141 tcatttttaa taatgtcaga tacatgtaca gtttcagcgg cctaagagcc tttaaagaaa 901201 aatataaacc ggagtggcga gggaaatact tagcgtatcg gaaaaacaga tctctttctg 901261 tcaccatgtt cctcgttaca cgtctgattg gcaaaagcaa aaaagactcc gtctaataag 901321 acggagtctt tttttatttc gtttttaaga agtaggtttc aatatcatca agcaggtagt 901381 ttgcggcttt aattccgcct gcggttgtcc atacgacgtc atcgacttca tgtgcattac 901441 ctgacttcac ggccttcagg tttttccata gtgaactgct tgtccactga ttggcccatt 901501 tttcattttc ttttgcatta tcggctttat aagtgaaata aaacagcaca tcagcatcca 901561 tatcaggaat agattcttta ctgtcggttg agaacgtaaa ttggtccttt tgtttcttaa 901621 acagttccac ttgtttttca gggcgtttga agccaagctg gtctaaaata atcccaggaa 901681 atgaatcggt ataatagatt cttgattcac cggataaaaa gcgtacgact gaaacggttt 901741 tgtttgtctg gtcgcccagc ttgtttttta aatcagaaac acgtttatca aaatcggcaa 901801 tgacttcctt gcctttgtcc gccttattca ccgcgttggc gtatagagtc aggttatcct 901861 tccagttccc ggccaaagat tcagcaaaaa cagtcggcgc aatcgcattt aactgatcat 901921 aaattttttc ctggcgcact ttgtttccaa taatcaaatc aggctttaat tctgcgatgg 901981 cttccacatt cggttccgtt tcaagaccga cgtttttaac acctttcatg tcatctttca 902041 gatagtcata ccacgggtcg cccttccatg actttacggc tccgaccggc ttaatgccaa 902101 gcgctaagag cgcctctgtt ccttcattag ttaaaacaac aatccgtttt ggattggcgg 902161 ggatgttgtc tgatgtcccc attgcatgtt tgaccgttct tgttttgctg cttgacacct 902221 cgctgttgct tgaactttct gaactattac aggcagaaag taccataacg gccattaaaa 902281 atacgaatag catgctgata tgctttttca tctttttcct cccaatattg aaattcatta 902341 tcatttagat cataataagc agtgttaaga gtgtcaatcc ctaattgagg attattctca 902401 aaaacaaaca ttacatagta aataactagg agaattagat catgatctgc aaaaaggcat 902461 cttcaaaatg gattgtgtta gtatgtctga ttttcatttt actgacggct gtctgcgcaa 902521 gcgtcgtgta tggctataca ggtacgtcat ggagacaggt ctatcaggcg tttacttcct 902581 tcaatggaac aaatgagcat gtcatcatca aggatgtcag gcttccgcgc gctttggttg 902641 cgacagtcgt cggcgcctcg cttgcagccg cgggcgctct catgcaggcg ctcacaaaaa 902701 atccgcttgc gtcaccgggg attttcggga ttaacgccgg tgcaggtttt tttattgttg 902761 ccggatcgtt ttttctgcat attcagtcac ctcaggcatt agtatggagc tcgtttctgg 902821 gggcagcatt taccgctgcg atcgtctatg cagcaggctc gcttgggagg gaagggctga 902881 cgccaatcaa actgacgctg gcgggagctg ccatggcagc catgttttct tctctgacac 902941 agggcttgct gtctgtcaac gaactcgagc ttgcccaggt gcttttttgg ctgactggct 903001 ctgtgcaggg ccggagtctg gatctgttga tgacgatgtt tccatatgca gcggcagcgc 903061 tggtaatctg cttctttctc ggccaaaaaa ttaatctcct cgttatggga gaagatgtgg 903121 caaaaggact cggccaaaaa acaggcctgc tgaaatttgt gatggcgctt tgtgttgtca 903181 tgcttgcagg gtccgctgtc gccattgccg ggccgatttc ttttatcggc atcattattc 903241 cgcattttgc ccgctttgtc gttggtaatg attatcgctg ggttctgcca ttttccgctg 903301 ttttgggtgc cattttgctt gtttgcgcgg atatcggtgc gcgatatatc attatgcctc 903361 aggaagttcc tgtcggggtc atgaccgcca tcatcggaat gcctgtgttt gtgtacatcg 903421 caagaagggg ggcgaagcta tgaaacttcg ttttggcgtt actgcggctg aaaagaaagc 903481 atggatcgtc tttttggttt tactggggtt aacagctgct gtactcatca taagcgctgg 903541 tctcggacaa aggtttattc ctccctggga tgtagcaaaa acattctttg gtgcaggttc 903601 caagctggat gaactgatga tcatgtcgtt ccgcatgcca agaattttga cggctttatg 903661 cgccggtgtc tgcttggcag cggcaggcgc gatattgcag gggctcgtca gaaaccctct 903721 cgcatctccg gatattatcg gaataacagg aggagcggcg gtagcggtcg tgcttttaat 903781 gatgttcttc tcagaccgca gcagttcact tacgatcagt ctgtcatggc ttccagcagc 903841 cgcatttatc ggcgcatcgg ctgtcgggct catcgtctat ttactggcat acaaaaatgg 903901 cgcctccaca tttcggctgg tgcttatcgg aatcggattt tcaatgtcgg cgcaggcgat 903961 gactaccctg ttgatgatca aaggcccgat ttaccgagca tcacaagcca atgtgtatat 904021 cactgggtca gtttatgggt caaactggca gcatgtaaaa atagctatta tcttatctgt 904081 cattctctta ttcatttgtt ttgtcgcgct aaaaaatatg aatatacagg tgctgggtga 904141 agatattgcg gcgggtgcag gaagcgctgt gcagcgaaat cgttttttct tgctcctttt 904201 gagtacggct cttactggtt gtgcagtttc agttgccggc acaatcggtt ttgtcgggct 904261 gatggcgccc catattgcaa gacggcttgt cggctcatct tatggcgcgc tgctcccagc 904321 gtcggcactt attggagctc tgctcgtttt aacagctgat atcgtcggca gaaccttatt 904381 tgctccggtg gaagtgccgg ccggcgtctt tacagcggct atcggcgcac cttattttat 904441 ttatttgctc tataaaacaa gaaattctta atcgttacac ccattttctt aaaaaagaaa 904501 atgggttttt ttgataatga ctgaagattc gtaattattt ttgctatact gacagagaca 904561 ttgataaaga aagggcggca gatgaatgaa agaagcagag gtattaaaat atgaagcatt 904621 tacaagcagt cccggcaaag gaaaccccgc aggcgtcgtt ttgcagggag acgattatac 904681 ggaagacgag atgcagatca tagctgaacg tgccgggtat tcagaaacct cctttatccg 904741 aaaaagcgag tcggccgatc ttgaactccg ttactttacc cctggacacg aaatgaattt 904801 gtgcggtcat gcgacagttg cttctcttta cgcattatgt gagaaaggaa tgctggagag 904861 cggtaaaacg tacagcatcc aaacgaaagc gggtatcctg cctgtgaaga tttctgaaaa 904921 agatggccgc attcatatca cgcttgaaca ggcctctccg caattcaaac catttacagg 904981 cgatcggaaa aaacttgcgg acgcactggg tatcaccgat gaagattttc atgaagacct 905041 tccgattgtg tttggcagca ctgggatatg gacagccatc gttccgctta aatcattgga 905101 ggcttccaaa aaaatggtgc cagataacaa acaatttccg gaagtgttag ttgatctgcc 905161 aaaagcttca gtccatccgt ttacctttga aaccgtccat cccgacagcg acctgcacgg 905221 gcgccacttt tcatccccgt attcgggaac gattgaagac cccgtgaccg gcacagcatc 905281 cggcgtgatg ggggcttata tgaaacatta tggcaatgcc gagcagcata aatttatcat 905341 tgaacaaggg caggaaattg gaaaagacgg aaaagtggag atcgaaatga acgaagccgg 905401 cggccatgtg aaagtgaaca tgacaggaac agccgtttac tcagaaaccc gtattcttaa 905461 aatctaatac ggatgatggt ttacaaaaag atgcactttc cgttatcatt atgaaatgat 905521 aatcattttc aattgcatag gaaggtgaga cggtatgcct caaaccgaac aaatacatca 905581 gcattcagta ctgagggaca tcatacgcag cagaagatcg attcgaaagt ttaaacaaga 905641 gccagtacct tcagcagtca ttcttgacat gcttgaaacg gcaaaatatg cgccaaatca 905701 cagagtgaca gagccatgga gatttattta cgtttccagt gagacaggta aagcgaacct 905761 cattaataca tttgcagcgt tctctaagaa atccaagccg gatatgacag aggaaaagct 905821 tcaaaatttc aaaaacacac ttgggcgcgt tccgggattt ctcctcgtcg tgtttcagga 905881 agatgaaaac gaaagagcgc gggacgacga ttttgcggca acaagctcgt tgattcaaaa 905941 tcttcagctt ctcgcttggg aaaaaggaat cggcatggtt tggaaaagcg gaaaaatcct 906001 ttatgacaaa gaagtccatc aggcctttgg tttacaggat aatgagcgtt tcgccgccat 906061 catacaaaca ggttatcctg acgaggcgcc ggaagtgaaa aaacgcacac cgatccgcga 906121 ccgattcact gaaatgtaaa aaaccccttg tctcaaacgg agacaagggg tttttcatta 906181 acgagatttc tttttcgctc tgttgtcggc tgctttcgca cgctcttgcg cttcgcggtc 906241 atctgcatca gcaagctcgg ttgaatattc ttcgtaaacg ccgtcagttt ccctttttaa 906301 ggcatcggga acttgtggaa gcttttgttt gtttttatca cggtttttgt ggatatgatt 906361 tctgcccata tcaaattccc cctaaaaagt gatatcaaac aaatatagta tttggtttta 906421 aggggctatg tattcctact tccgcttagc agctttttcc gcttttttaa attcgcctga 906481 ataaagaact tcctgcattt ttttcaggtt ggcgccttgc tggtgcttct ccctcttttt 906541 ttccataaaa aggacctcct tcaaccatgt tattcttaag gttgacgctt cctgctgttt 906601 ttatacagtc tttcggtccg ctatcagctg tgagagtgca aattcaagat ccgaatatgt 906661 aaaacgaaat ccagaggtta tcgctttttt cggaagagcg cgctgtcctt tcacaatcaa 906721 aagactcatt tcacccaatg cttttgataa aaagaattcc gggacgggga gccagtgcgg 906781 gcggtgcttc acccgtgcaa tcgtttttcc gaattgcttc atgtccacag gattgggcgc 906841 ggtgacattc attgggcctg agatgccggc gttttccacc gcatatcgga tcatctgggc 906901 cgcatcctcg acatgaatcc atgacagcca ctgccttccc gttccgatcg ttccgccggc 906961 cagaaactta taggggagaa tcatgagcgg gagagcgcct ttttctccaa gcatcacgcc 907021 aaatctcgca taaactgtcc ggatgcccat cgcttcaata tgctgtcctt ccttttccca 907081 caggtgtgca gtatggctga gaaaatcctc atctgacgtt gcagaatcct ctgtgaaagt 907141 tttctcaagg cttgtgccgt aaatgcccac ggcactggct tggatcaatg tcttcggctt 907201 ctccttctgt ttctgaataa gccgctgcac ttcacgcgtc gcattgatac ggctggagag 907261 aatgtgctgc ttcgtttttt ctgtccagcg gccaaaaatc gattttcccg caagatttat 907321 ccagacatca atatgaggaa gttcctgctc cggtgcggct ccttccgaca gccattggac 907381 atatgtcata tttttttgtt cagtttccct tgcgtttctt gataaaatat aaacatggtg 907441 tccctggcgg gtaagaacgc ctgtcagatg ctggccgaga aaaccggttc cgcccgtcat 907501 tgcgatattc atgaacatct ctcctcatcg ttctaataaa tatactttac ctcattgtaa 907561 taaaagaaaa cgcgtttcag gcctgagaag ggagattaag atgccgttta ttacaaaaat 907621 atcaacgcaa aaaaagaata cggaacgctt caatattttt ctggatgata aatacgcctt 907681 cagcgtggac gcggatgtgc tcgtgaaatt tgagctcaag aagggaaaag aactcgatga 907741 tcttgacatc attgagattc aatacggcga tgaagtgaag aaaggcttca accgtgcgct 907801 tgacttttta tcctatcgaa tgcggtcgac gaaagaggtc gaggatcact taaagaaaaa 907861 agaaacctcg ccccccgtca ttgcggaagt catccatagg cttaacgatt acaagtactt 907921 aaacgaccag gaatttgccg cagcctatgt cagcactcac aaaaaaacaa acggaaaagg 907981 ccctgatgtt ttgttcagag agctaagagc gaagggaatt gatgacgata caattaagga 908041 ggcgctaagt tccttttcct ttgaagatca gacaagagaa gcggtcaagc atgttgaaaa 908101 gcttctcaaa aaagataaaa agctttcgac gaaagaactc aaacagcgcg cccagctgca 908161 gcttcagcgc aagggcttct catttgatgt tatcagcgcg gcgatggatc agattgaata 908221 tgaaaatgat gaagacacag agaaagaagc gctgcgcctt cacgcggaaa aagcgtttag 908281 aaaataccgc tatgacggct catatgaaag cgccatgaag gtcaaacaat ttttattccg 908341 caaaggattc tcactcgatt taatcgagca attactgcag gaagaggagt actgaaatgg 908401 agaaacgata cagtcaaatg acaccgcatg aactcaatac cgaaatcgca ttactttctg 908461 aaaaagcaag aaaagccgaa cagcatggaa tcataaacga actggcagtg ctcgaacgga 908521 aaattacgat ggcaaaagca tatttgctga acccggaaga ttactcaccg ggagaaacat 908581 atcgtgtgga aaacactgag gacgagttta ccatcagtta tttaaatggc gttttcgcat 908641 ggggatacag gacctcttcc cctcagcaag aggaagcgct gccaatctca gtattgcaag 908701 aaaaagaata aagcgtaaca ggaggctgat gatcagcctc tttttgtttg cagcacattt 908761 acacgaattc ttaaagaaaa aatcattgaa ttcacttgaa aaatctttta agatgaaact 908821 cgttgttttt taaaatcaaa ggaggcgatg acgttgagta tcaaaaaccc atctgtaaaa 908881 tttattatat ttgttcttat gatttgtaca ttttcaatcg gctatacaga atacgcggtg 908941 atgggtattt tgacgtcgat tgccaatgac tttcatatac aggtttcatc cgcagggctt 909001 cttgtcacgg cttatgcggc aagcgtttgt ttgacagggc cgctcgtcac catcatttcc 909061 gtcaagcttc cgagaaagcc tgtgcttctt gggctgatgg cgatatttat cctttccaac 909121 ctgatgagcg cactggcgcc gaattttgcg gtattggcca tttcaagaat tttatctgcg 909181 tccattcacg gcgctttctt cgcgattgcc atggtattcg caagtgaaat ggttccgccg 909241 gaaaagcgtg ctgcagctgc tgcttcaatg aacggcggac tgacagtggc tctaatgctt 909301 ggtgttccat tcggctctta tctcggagat gtcctgaatt ggagagcggt gttttccatc 909361 attacggcac ttggtgtcat cggattttta ggccttatgg ctgccgtgcc gaacagaaaa 909421 ccaaaagtga tcccaatgct tatgaatgag tggggtgttt ttaaacacaa acaagtgctg 909481 ttttccttcg cgattaccat tttaggctat tccggtgtct ttatcgccta cacctttatc 909541 gaacccattt tgaggcattc agccggattc agcacggttg gcattacagg tgctctcttt 909601 gcgtatggat tgggaggcgt tgccgggaat ttctttgctg gaaaggtacc gctgcctttg 909661 ctgactcgga cgatgatcgg cgtaatgatc ggtttaatcg gtgttctggc tgtatttcct 909721 tacatcgcca tttacccggc tgcagccatt gtggcaacgt tcctattcgg ggcatgcgca 909781 ttcggcacgc cgcctcttct gcaaacaaag gtcatttcct catctgaggg cggcacaacc 909841 attgccgcag ctgtcagcgt atcagcattt aaccttgcca atgcccttgg tgcatggatc 909901 ggcggaatga ttttaaacgg aacaggctct tattcctggc tgtttgcagg aggtgcgctt 909961 atgaccgcat gcggacttgt gctttctacc ttcgcacact tatcagaaaa gaagagcgtc 910021 tacgaatatc aagtcaataa agggtaaaaa acagctgcag tgtatgcagc tgttcttctt 910081 taccgtttgc ctgaggctct cattctttct tgaggatgct gattgataga tccgtcagca 910141 cgctttgaag catagtcgtc ctttgctctc ggttcaccct gaaatttgtt ttcgttttcg 910201 taaggaaatc ctttttcttt atttcggacc atgtcatatc cccctaggtt cgagatcaaa 910261 aagttgcgtc ttttcagatg aagacgtaag gttagtatat ggagaacacc acgtaataaa 910321 gcgttatttt tttcctgaag aaaggagact gcacacatga atatgtacat tgagaaactg 910381 actaatctgc ttctggaaaa gaacgagatg atcagctata tacaggcaaa aacgtgggtg 910441 gaattgttat ggagcgattt cgaagcaacc tacgcaaaag ccggacacgc ctatcaaggt 910501 gaaaaaatga ctgaaaaaat cgtcacacaa tggattgaaa actatggcgg ccagctccac 910561 ctttttcaaa gctcccgtaa cgacgtgaat gattacttaa atcaaagcag aggccttttg 910621 cattaaaaac ctgccgttaa cgaccggcag gttttttcat tttcttaaaa ttaccttaac 910681 aggaagaaat cataaacaaa acatgtttca ccagcctgtc aatcagggaa taccacttat 910741 atcttgtcaa aatgcgagga ggagctttat atgaaaaaga aacaagtaat gctcgcttta 910801 acagctgccg caggactggg tttgacagca cttcattccg ctcccgcagc aaaagctgcg 910861 ccccttcacg acatatctgt cagcatgcca tcatccgata cttacatcat aaaagcagga 910921 aagctgaatg tccggactga gccaaatcat gaaggtgata ttctcggcac tgtatcatca 910981 gaacaaaagg taaaagtcga taggttcgta aatgccgatt gggctcaaat tcatttcaaa 911041 ggaaagaaag catatatttc aactcacttt ttaatgaaaa ccgcaagcca agcgaaaaca 911101 acgaaacaga cagccttcta tacaccgacg cccgaaaacg gaaaagctaa gcagctctca 911161 tctggaacag aggtgacaat acttgggtgg ggattcagtg aaaacggcgg atttgacttc 911221 acttgggcgt tcgtggatta tggcggagtt aaaggctata ttcacacaaa ggatttacaa 911281 atgcgataaa aaggcaggcc gaggcttgtc tttttgccta tgcatgaaac atttcttctt 911341 tctgcacgta acaatgagaa aggagatgat gatatgacgg gtttagtcgg cggagggctt 911401 atgatcattg cgggcatact gatcaaactg tttcctccca aatcgatcaa cagtgtgtac 911461 ggatacagaa cgagacgctc aatgtcagat caaagattat ggaatgaagc gaaccgttac 911521 agtgcatcat taatgatcct gtcaggcttg gtgattgcgg gaatgggttt gctgctggga 911581 tcaaacttgt ttattcttca gcttatcctg ctgattgccg cctgtgtcat aacatttatg 911641 ctaacggaga aaaggctgaa aatcatgacg cacagtcaag gaggagatag aagtggacgg 911701 agttaaatgc cagtttgtca atacgaacgg aatcacgctt cacgttgcag ccgcaggacg 911761 ggaagatggc ccgttaattg tcctgctcca tggatttcct gagttttggt acggctggaa 911821 aaatcaaatc aaaccgcttg ttgatgcggg ttaccgggtc attgctcctg atcagcgggg 911881 ctacaatctc agtgacaaac cggaaggaat tgattcgtat cggattgata cattaagaga 911941 tgatatcatc gggcttatta cgcaattcac tgatgaaaaa gcaattgtca tcggtcatga 912001 ctggggagga gctgtcgcat ggcatttggc ttccacacgc ccggaatatc ttgaaaaact 912061 gatcgcgatc aatatcccgc acccgcacgt catgaaaacc gtaacgccgc tttatccgcc 912121 gcaatggctg aaaagctcgt atatcgcata cttccagctg cccgatatac cggaggcatc 912181 actaagggaa aatgattatg atacattaga caaagcgatt ggattatccg accgtcccgc 912241 gctttttaca tccgaggatg tcagcaggta caaagaagcg tggaagcagc cgggcgcgct 912301 gacagctatg ctgaactggt acagagccct cagaaaagga agcttggcag agaaaccctc 912361 ttacgaaaca gtaccttacc gaatgatctg gggaatggaa gaccgctttt tgagcagaaa 912421 gcttgcgaaa gagacggaaa ggcattgccc gaatggacat ctcatctttg ttgatgaagc 912481 ttcccattgg attaaccacg aaaagccagc catcgtcaat cagctgattt tggaatatct 912541 taagaaccaa taagctaaaa tttctctcca tccgtctgtc ataatggcag actttttctg 912601 tgcgtttttt ttcatagtct gttttaaaca tgacaaaata acattaaaaa tcatgaatgt 912661 caccataaaa ttgtaacaaa aaacaggttt aaacgacttt aaaaaaagga atagccttac 912721 tgaagatttg tgtaaaactc ccctaaggca atacttaaaa agaataataa aaagaaggtg 912781 ccttaatgaa gcaaggatta atctcgatta ttatcccgtc ttacaatgaa gggtataatg 912841 ttaaactcat tcatgaatct ttaaaaaagg aatttaaaaa cattcattat gactatgaaa 912901 tattcttcat aaacgacgga agtgttgatg acacgcttca gcagatcaaa gacttggcag 912961 cgacgtgcag ccgggtaaaa tatatatctt tttctcgaaa ctttggaaaa gaagccgcaa 913021 ttttggcggg ctttgagcat gttcagggcg aggcggttat tgtcatggat gccgatctgc 913081 agcatccgac atatttgctg aaggaattta tcaaaggcta cgaagaaggg tatgaccaag 913141 tcattgccca aaggaacaga aaaggggaca gctttgtccg ctcactctta tcatctatgt 913201 attacaagtt cattaataaa gcggtggaag tcgatttgcg tgacggtgtc ggtgacttca 913261 gattgttaag ccgccaagct gtgaatgcac ttttgaagct gagcgaagga aaccgcttct 913321 caaaaggcct tttttgctgg attggctttg atcagaaaat tgtattttat gaaaatgtcg 913381 aacgaaaaaa cggcacctcc aaatggtcgt tcagcagtct gtttaactac ggaatggacg 913441 gcgtcgtttc atttaatcat aagccgctga gattatgttt ttatacaggc attttcatcc 913501 tgctgctttc catcatttat atcattgcca cattcgttaa aattctgact aacggtattt 913561 ctgtgcctgg gtatttcacc attatctcag cagtgttatt tctcggcgga gtacagctgt 913621 taagtcttgg aataataggt gaatatatcg gccgaatcta ttatgaaaca aaaaaacgcc 913681 cgcattattt gatcaaagag gcgaatatcc cgaacaaaga cctgcctgaa acgaacgaat 913741 taaaaagcat gcggcgtctg acaaaaatgc actgaaaata ccaagcgcca ttggcagtgc 913801 tttttttgcg tgtctattat cttaaaagca agactggaga attcatatga aaagaaaaca 913861 tatcatgatc tatgcggcca gtttgctggt gtccgttctg gcacacgctt tttttgtgaa 913921 agaatgggcg gaaggcaggt atatgacagg tccgggtgac gggcttgcgc aaatgatcgt 913981 atttaaaaaa ttattatttg accaatatac acacgggaat tttttctaca attattcatt 914041 cggacttggc ggcggcacat tcagtcagct cggctattat ttttctgcgt cttttctttt 914101 tcttgctgtg tctgccgctg tttggctgct tcaagccgtc cagctgatcg gagaaacgga 914161 tacgcttttt tgggcagagt cagctgtttt tatcagtatt ttcaaattga gcttgatcat 914221 ctttacgtcc gcttctgttt ttcattatct tcttaagcac agggcggcat cgttcacggg 914281 agccgtgtta tacggcgtct caattattta tttccgtcac gaagcgtatt gggaattttt 914341 caccgataca atggtttggc ttccgctgct tgtgcttggc gcagaaaaaa ttattagaga 914401 gcggcgtccg gcgtggttta tcgttgcgtg ttcgctgacg ttaatcaaca atttttactt 914461 tgcatacata aaccttatat tcatcggaat ctatgtgctg ttcagatggc tgatccgttt 914521 ggaaccacat gaagagaaaa gatggattca aatcagatta tttctcgttt caggcttcat 914581 ttcttttggc atcagtgcgg cggcgtttgt gccggtagta tacggttttt taaacaacct 914641 gcgccctcca tacagccaga aaatagagtg gctcaatttc gatgataata tcttattttc 914701 gagccggatc atcattgtgc cggccgcttt tctgctgttt ttgtttatta tttcttttta 914761 caaaaaccgt gtgtttcgtc tctttgccgg gttgagcctg ctgtttattc tgtttcattt 914821 cagtccgtat gcggcaagcg tctttaacgg tttttccgcc ccgcaaaacc ggtttgaata 914881 tgttctggcc tttaccattg cgggagcagc tgcggctggt ttgtcacagc tgtctgaatt 914941 gaaacggaaa gaactgctcc cggccgcagc tgtcgtcctg cttctttact tgtatcatat 915001 ccaaaggtat aagctcgata tatggaagcc tgcgaatgaa agtattctat tgctcttact 915061 catgacaatc gcagccttgt ttgctgcagc ttttgcgaaa aaacgggcaa aaatggctgt 915121 gtacggtata atcattcttt cttcgctgtt tgtcgccaac tcctatcaaa aatacgcgct 915181 ctcagaaggc ggcgatttgg acagtgtgac aaaagaatat cttacaagtg aggaatacag 915241 agggcgggaa tcatctgagc tcatcagacg tttacagaag gaagacgatg acccgctcat 915301 gagaatcgac tggatgaacg gggtccgcaa taatacgcca atcatttacg gatttaatgg 915361 cttcagcgcg tattccagca ttttaaacaa agatctgctg gccttctatt ggaatgattt 915421 aagcatcgat atgggcaggg aaagcgtcag ccgttacgcg tcattgggag acagggcgaa 915481 tttatacagc ctgctttacg gcaaatatta tatgaccgaa aaaacaaacg aagccagcgt 915541 cccgtacggc ttcaaaaagc atttagaaac agagcattat gcagtttatg agaatcagta 915601 catgcttcca ttcgttaaaa cagcggatgc catatacagc gaaagtgagc tggaccgatt 915661 gcccgctctt gcgaaagaac aggcgatgct gaaaggaatt atattaaaag atccatcagg 915721 aaaaacggag cagacaccaa aaccgtccaa tttgatcacc aagtcggaca tcaccgcaaa 915781 acaagcccag tatcaaaacg ggctgctaac cgtaactgga gaaaacggag gagagctgat 915841 catcaccccg aaacagccat catccgctcc gggagactac tatgtcagct tttatttgaa 915901 aagcaaagca aaagacaaag gatttacatt aaaggtaaat gattatgtca caacaaggaa 915961 atcgaacaaa tcgatctata aaaccggagt aaataatata acggtaagag tgcctaaatc 916021 aggccatatc tcaatcaatc ttccgaaagg aacctatgag ctgagaaaca tagcgctcta 916081 tgaagaaaat taccaaacgc tgaaaaacgc tgtaatgcaa aataaaacag agaaagcaga 916141 caaactgaat tggaacaaaa atcgactgac cttttcctat catctgtcaa aagaccagta 916201 catcatgctt ccgatcccat atgaaaaagg ctgggagctg aagatcaacg gaaaaacaca 916261 gaagatcgaa aaagcggatt atgcttttat aggcttcaag gcgcaaaagg gagacaatca 916321 cattgagctg acttactatc cgccatactt caaaatatcg gcgatcatat ctctcgtcag 916381 tctgctgctt gctgtttttt atataagacg taaaaagccc ggctctatat agagccgagc 916441 tttaattttt tctgaagttt ttcttcgctg aatatccatc ccgtatagga tgaacgaatc 916501 gtgagatcat ggccgatatg aacaattgcg acaaacggat aatggccttt gctccgataa 916561 cgcaggtcga taaatctcac ctcataatga tctttaaacg tatccacttc ccaccggtat 916621 accggagaaa aggacagaaa cgccgcgatg ttatcatcct gctttgccgc atgcattaca 916681 tcggtttcag gaacaggcac ccgattaaat gtatccagaa tcacgacatg tccttccatg 916741 cttcttccta catagaaagc atgtgctgtc gtcactgcga ttcgccattg cctgaatttc 916801 atcgttggag aaataataat gctttcgatc tcatcatgaa tcatctcatg aagcttccgt 916861 ttaattctca gctgcatgat caggcgcacc aagtagtagc ctaccaatat gatatataag 916921 ctgagaaacg tgatgccggg actcccgcct gcataccaaa tcgcgatagc tgccagatgg 916981 ctgataaaaa taaacggatc aaacgtatta atcagcccga gcgcaaccca ttttttcgaa 917041 aacggacgaa tggcttgtgt tccataggcg ttgaatatat caacaaagac atgcagaacg 917101 actgccagca gtgtccacag ccacaggtgc agaaaatcgg cctgaggata aaataaatac 917161 agaatcgccg ggatgatgac agaccaaaac aaaacggcgg gaattgaatg ggtaaatcct 917221 ctgtgattcc ttatataaac agcattgttt ttaagcttta acacagtatc aatatccgga 917281 gcctgagagc ccgcaagcgt tgcgatcata acagcgtgag ccattgccgg atctgatccg 917341 acaacaggat caagcgtcgc aataccgccc agtgcgatgc ccataacgac atgtgtgccc 917401 gtatccatag gtgacctcct tgcagggtga tcctgcacat tcactttgta agaaattccc 917461 cattttcata tacccaattt ttaaactgat tcaatcgttc tcatatgttt ccgctttttc 917521 tttattacta tttaatgtaa catattatcg tactgtgccc ttagtgtaca acaaaaaaca 917581 gtctaaagaa aagcggggcg cgaaagactg gggagaaaca catatgaacg tacttgaaga 917641 caaattaaaa caaaaagaca tacagcaatt tcgcgatgat ttaatctcat ggtttgaacg 917701 agagcagcgc gttttgccgt ggagagagga ccaagatcca tataaggtgt gggtatctga 917761 agtgatgctg cagcaaacga gagtagagac agtgattcct tactttctcc ggtttgtaga 917821 acaattcccg acagtggaag cgctcgctga tgctgatgaa gaaaaggtgc tgaaagcatg 917881 ggaagggctc ggctattatt cgcgagtcag aaacctgcaa agcgcggtaa aagaagtgaa 917941 acaggaatac ggcggcattg ttcctccaga cgagaaagat tttggcgggt taaaaggcgt 918001 cggcccttat acaaagggag cggtgctcag cattgcctac aataaaccca ttcccgcggt 918061 tgacggaaat gtgatgcgtg tcatgtccag gattctatct atttgggatg atattgccaa 918121 accaaaaaca agaacgatct ttgaagacgc catacgagct tttatttcca aagaaaaacc 918181 atctgaattt aatcagggct tgatggagct tggagccttg atctgtacgc caaaatcacc 918241 ctcatgcctg ctttgcccgg ttcagcagca ttgctcagca tttgaagaag gcactgaacg 918301 ggagcttccg gtaaaaagca aaaagaaaaa gcccgggatc aaaaccatgg ccgcgatcgt 918361 actgactgat gaagacggac aagtgtatat ccacaaacgg ccgtctaaag gtttgctcgc 918421 caacctgtgg gaattcccga atcttgaaac acaaaaaggg atcaaaactg agcgtgaaca 918481 gctcattgct ttcttagaaa acgaatatgg catacaagct gatatcagtg atctgcaagg 918541 tgtagtcgag catgttttca cccacctggt atggaatatt tcagtgtttt tcggtaaagt 918601 aaaacaagtg tcggatacca gcaagctgaa aaaagtaacg aaagaagagc tcgaacaatt 918661 tgcgttcccg gtgtcacatc aaaaaatctg gaagatggca ggagaagcag ccgccatctc 918721 ggctgctccg taaaccattc ttaatcgtaa gagacgcgcg tgccgtggct gtagtccgct 918781 tcattgcgct tcattccgcc gcgcgcttca atttcttgcg ttaattcccg gtattttgat 918841 tggccttctt cgttcaaata aggcataatt tgctgaaagg catgatgaaa ataagcgagt 918901 tcactgttct tccaatcttt tttggaaacc atgttcaatt cgctcatatc acgtccgaca 918961 tacataacag aagaccccct ttaaagttct tgccattatt gtttgtggaa ataaaagaac 919021 tatacgctac aaggagatga ggaaaaatgg aacaaaataa atgtgcactc gtaacaggaa 919081 gcagccgcgg tgtcggaaaa gcggccgcga tcagacttgc tgagaacggc tataacatcg 919141 tcattaacta tgcacgcagc aaaaaagcag cattagaaac agcggaagaa atcgaaaagc 919201 ttggcgttaa agtgcttgtc gtaaaagcaa acgtaggaca gcctgcaaaa atcaaagaaa 919261 tgtttcagca aattgatgaa acgttcggca gacttgatgt ttttgtcaat aatgccgctt 919321 caggagtact aagacctgtc atggaattag aagaaacaca ctgggactgg acgatgaaca 919381 ttaatgcgaa agcattgctt ttctgcgctc aggaagctgc caagctaatg gagaagaacg 919441 gtggcgggca tattgtcagc attagttcat taggctctat ccgctatctt gaaaactaca 919501 ccacggtcgg tgtatcaaaa gcagcgttag aggctttaac ccgttatctt gccgttgagc 919561 tttcaccaaa acaaattatc gtcaatgctg tttcaggcgg agcgatcgac acagatgcgc 919621 tgaagcactt cccgaataga gaagatctgc ttgaggatgc gcgccaaaat acgccggcgg 919681 gacgcatggt cgaaattaaa gacatggttg atactgtgga gtttctagtg tcttccaagg 919741 ctgacatgat ccgcggacag acaattatcg ttgacggcgg acgctcactg ctcgtttaaa 919801 aatttttaaa aaagaggaat agctatacga tcacctgcac attctaatga ccgtggaggt 919861 gataacaatg gctaactcaa ataacttcag caaaacaaac gctcaacaag ttagaaaaca 919921 aaaccaacaa tcagctgctg gtcaaggtca atttggcact gaatttgcta gcgaaacaaa 919981 cgctcagcaa gtcagaaaac aaaaccagca atcagctgga caacaaggtc aattcggcac 920041 tgaattcgct agtgaaactg acgcacagca ggtaagacag caaaaccaat ctgctgaaca 920101 aaacaaacaa caaaacagct aatcactgaa acagaaaaaa gcacttcatc ttcgggtgga 920161 agtgcttttt tctgtttgaa aaacgacaaa acttgtggaa ggtctacaga atgagtcaaa 920221 gggtttgctt tatggagatc gaaatgatta aaggaggaaa tgtttatact ttcatcaggc 920281 tgaaggagga accgatgacc gaatttgaaa agctggtaag tgaacagatg aaaacgatgg 920341 ataagcttct cgatctccaa tcagagctcg accgctgcaa acaaattgag gcggaactcc 920401 ggcatttgga aagggatgca aggctgcgtg ggattcaggc tgaaattgcg gtaaaacgga 920461 aacaccttgc cgatatacag gatatgtttc aaaagcagac agagcaggtc attcgttcat 920521 atcgcagctc agaaaagccg tcttcctttg tgtagtgcag gaatgtgcca ttccccggcc 920581 ggaatggctc ttttattttc atttttcaat ttgtaacgtt ataataggta aaagacgttg 920641 tcggtaagca aatttggaca tactaactgt agggctttat agaaagtagg ggagaaatat 920701 gggctatccc aaggaaggag aaaccattca aattcacagc tataagcaca acgggctgat 920761 tcatagaatt tggaatgaga caacaatctt aaaaagtaca gaaatgtgtg tcatcggagc 920821 caatgaccgg acgatggtaa ccgaatcaga cggccggaca tggataacca gagagcccgc 920881 aatctgttat tttcacgcaa gacaatggtt taatgtcatc gggatgctga gggaagacgg 920941 ggttcattat tattgcaaca tcagttctcc gtttgcctat gatggcgaag caattaaata 921001 tattgattat gacttagatg ttaaggtttt tcctgacatg acctacaata ttctcgatga 921061 agacgaatat gatgatcatc ggaaagccat gaattatcca aaagaaatcg acagtatttt 921121 aagagactac ttaaatacgc tgctccattg gattcaccag cgtcagggac cgtttgcgcc 921181 cgagtttgtc gatatgtggt atgaacggta tttgcgctat acaaaataat ggttacgtaa 921241 aaacctgttg cggggtacaa caggtttttc acatgggctc acacacatca tgataaagag 921301 agagggggaa tcaaccgtgg gggttatgaa acgctacatg caattcgtca aaccttataa 921361 gaagcaaatt ttcgttacag tgttaatcgg gatcgtaaaa ttctccattc cgcttgctct 921421 cccattgctt ctgaagtacg tagttgacga cattattcaa ggaggcggca cggccagtga 921481 caaaaccacg tcattgttca cgattatggc gatcatgttc gccttatttt taattttgcg 921541 cccgcctgtt gaatattacc ggcaatattt tgcccagtgg actgccagca aggtgcttta 921601 tgatataaga gctaagctgt ttgaccatat acaaaaactg agccttcgtt tttacgcgaa 921661 tacaagaaca ggggaagtca tttcccgagt gattaatgat gtagaacaaa caaaggattt 921721 cgtcatcaca gggctgatga atatatggct cgatatgctg acgattttga ttgtaatctc 921781 tatcatgctc acactggacg ttaaattaac gctgatctct atcgttttat tcccattata 921841 cggaatatca gtgaagtatt tttacggccg tttacgaaag ctgacaaggg agcgctcaca 921901 ggctcttgct caagtgcagg ggcatttgca tgaacgcatt caaggcatgc ctgtcatcag 921961 aagctttgcg atagaagatc atgaacaggc tcaatttaat gagaaaaacg gtcatttctt 922021 agataaagcc atccgccaca cgaattggaa cgcgaaaacc tttgcggtcg ttaataccat 922081 tacagatttg gcgccgctca tcgtcatagc gtgcgccggg tattttgtca ttaatggacc 922141 gctgacagtc ggaacaatgg tcgcgtttgt cggatatatt gacagaatgt acaaccctgt 922201 tagaaggctg atcaattcct ctacaacttt gacacagtca atcgcatcaa tggacagggt 922261 gtttgaattt attgacgagc cctatgaact cactgacaaa ccaaatgcga taaaggccga 922321 tcagattcgc ggaggagtgg agtttcaaaa cgtttcgttt caatatgaga aggacaaaga 922381 aaatattctt catgatgtat ccttaaaagt aaatagagga gaaactgtag ctctcgtcgg 922441 catgagcgga ggaggaaaat caacgctcgt cagcctgatc ccaagatttt atgatgtaac 922501 aagcggcaga ctgctgattg atgggacgga tattcgcgat tatgaagcaa gaagccttcg 922561 caaccaggtt ggtatggtgc ttcaagatac ctttttattt agtgaaacga ttcgggaaaa 922621 tatcgcgatc ggcaagcctg atgccacact tgaagagata atcgaagccg ccaaagctgc 922681 aaatgcccat gaatttatca tgagttttcc agaaggatat gagacccggg tgggggaacg 922741 aggcgttaag ctttcaggcg gacaaaagca gcggatctca attgcgcggg tattcctgaa 922801 aaatccgccg ctcctcattt tagatgaagc tacatcagct ctggatttgg aaagtgagca 922861 ttacattcaa gaagcgatgg acaaactggc gaaggataga acaacttttg ttgtcgccca 922921 ccgtttatcg acaatcaccc atgcggataa gattgttgtc atggaaaacg ggacaatcat 922981 tgaaatcgga acccatgatg aactcatgga ctatgagagc caatacaagc acttatttac 923041 cattcaaaat ttgaactaaa acatcaatct tatatccttt taacgaagga tataagattt 923101 ttttgtatat aaaaaaaccc ggctgtttaa ccgggttact cttctgtttc tatttcgcag 923161 tctttcggat gatacgtttg aaaacttgtg ataagtgttt ctaaatgttc aagctgctcg 923221 cgatattcca cggcgcttgc cataatattg agcatgttgt aatcaataag ctcctcatcc 923281 gtattctgct gattttttaa aaatgacttt gttaaaagct gcttataccg gatgccttct 923341 tcaaccgcgt catcatgcgg cttgattttt ccgacaaacc tcatcaaaat ccgctcgtgc 923401 cagtaaagca ggtaatcaag ttcttcagtc aatgtttcct gaaactcttc cggcatatga 923461 tagatctcgt tttccagacg atgcagcttc ttcaatgtat caagcgcccg atttgcagta 923521 ataatggcct gtctgaacag gacaagcttt cttgatttca cataagtcgt tttcttaaag 923581 taacttcttt cttctttata tagaagatat gtctgatcaa gcttgatcat tttttctttc 923641 agtttttcaa tatcctcttt caaaatcgaa tgctctgtcg actgccgcat ggacaatctg 923701 atccacttca taatttcttc ggtgttttcg acggtattat gaatcagctt tgtttcgtac 923761 ttaggaggca aaaacacaag gttgacgata aaggaagaaa gcacccctaa gatgactgtg 923821 cttgttctga tcagcgcgaa cattaaaaag tcgtcaccgg cagattctaa tatcgcaatg 923881 actgttacaa gagcaattga aattgtatgt tcaattttaa gtttcagcat gattgtaatg 923941 acaataactg ctgttaaccc gatcataatc gggctgggtc cgaaaataag gccgaacact 924001 gtggcaatca cagctccgat gatatttgct tgaacctggt caataataat gagaaaagag 924061 cggtaaatcg acggctggat cgcaaatatc gctgcaattc cagcgaaaat cggcgcggga 924121 agcccgatcc acgaagccaa ataaagggca agtgtaatcg caatcccggt tttgaaaatg 924181 cgggcaccaa gtttcattgg tttgtgcgtg cattcctttc tatagtaaat tgtgtgacat 924241 agcaaatggg ctaatcctta aaattcccgg ttagtttatt tgctaaacaa ttaagtaata 924301 tacagggatc gatacaaata ttcaagctat ttttctagaa aaagaccaaa atcttacacg 924361 ctgtttgatt ccataaaaaa acaggagctc aaagctcctg ttcaaggtat ttgattctag 924421 ttttttagat gtttaaatgc atcctcgacc gctgtaagcg tgtctttaat atcctgctct 924481 gtatgtgctg tggtaataaa ccaagcttca tacttagaag gtgctaaatt aattccgcgt 924541 tccagcatca gcttgaaaaa cgtagagaat gtttctccgt cactccgttc agcctgctcg 924601 taattttcca ctttctcatc agagaagtat accgtgagcg caccttttaa ccggttgacc 924661 gtaatggtga tgccgtgtgt ttctgcgtgc ttcaaaatgc cttcctcaag catagcgcca 924721 aggtgatcaa gcttttcata cacgcctttt tctttgagca cttccagaca agcgatgcct 924781 gataggatgg aagcggggtt ccctgccatt gttcctgcct gataagcagg ccctagcgga 924841 gctacctgct ccatgatttc ttgtttgccg ccataggccc caatcggaag tccgccgccg 924901 ataattttcc cgagtgctgt taaatctggt ttcacctgta agagatcctg cgcgccgcca 924961 tacataaagc ggaaagccgt aatgacttca tcgtaaataa cgagagcccc tgcattatgt 925021 gttaattcat ttacttgttc taagaagccc tctttcggct ccacgatacc gaagttgccg 925081 acaatcggtt caacgagaac cgccgcgatt tcactgcccc atttttcaag agctgcttta 925141 tagctatcga tatcattaaa tggtactgtg atcacttcgt ttgcaatgct tttcggtaca 925201 ccggctgagt ctggtgtgcc gagagtagac gggccggagc ctgcggcgac aagcacaagg 925261 tccgaatgcc cgtgatagca gcccgcaaat ttaatgattt ttgtccggcc tgtatatgcg 925321 cgagccacgc ggatggtcgt cataacggct tctgtacccg aattgacgaa tcttactttg 925381 tccatagcgg gaatggcttc tttgagcatt tttgcaaatg taacctcgtg tttcgttggt 925441 gttccataca atacaccgtt ctctgctgct tttttaatcg cttctgtaat atgcggatgg 925501 gcatgtcctg taataatcgg accgtacgcc gctaaataat cgatgtattt gttgccgtcc 925561 acatcccaaa aataagcgcc gcttgctttc tccattgcaa caggagaacc gccgccgact 925621 gctttatatg atctagacgg gctgtttaca ccgccgacaa tgtgctgtaa tgcctcattg 925681 tgaagttcaa ttgattttgt atgcaagaat aaaaacctcc tatatctcca tgcgtccttt 925741 ctattgtagc atgcttccga acaagaacaa tggcttcggg cttcagattc agctgagatg 925801 gttgtaatct ggacaagaat tggatacgct taataaaaaa acatccggag gtaacgtaat 925861 gactatagaa atcggacaaa aagcgcctga tcttgagtta aaaggtgatc atggggaaac 925921 agtaaaatta tcggattata aaggaaagta catcgtgctt tatttttatc caaaggacat 925981 gacaccggga tgtacaactg aagcatgcga ttttcgggac agtcacgaaa gcttcgccga 926041 actggatgcc gtcattatcg gcgtcagccc ggacagccag gaaaaacacg gaaaatttaa 926101 agagaagcat aaccttccat ttctgcttct tgttgatgac gagcataagc tggcggaagc 926161 atttgatgtg tggaagctga agaaaaactt cggaaaagag tatatgggaa tcgagcgttc 926221 cactttttta attgataaag aaggccggct cattaaagaa tggagaaaag taaaagtaaa 926281 ggaccatgta gccgaagcgc ttcaaaccct caaagatatg tctgaaaagt aaatctctat 926341 gagcctatgc ttacttttac cctgatatca attgacaaat tatcgtagaa agagttacac 926401 taattataaa cattacaatg taagaatttt ttttagaaga gaggtgcatg acggatggct 926461 gcacatgaac taaaagaagc cttagaaacg ttgaaggaaa ccggagttcg cattactcct 926521 caacgtcatg cgattctgga atatctcgtt aactctatgg ctcatccaac agcggacgat 926581 atatataaag ctctggaagg gaaatttcct aacatgagcg tagcgacggt atataacaat 926641 ttgcgtgtgt tccgggaatc aggtttggta aaagagctca catacggtga tgcttccagc 926701 agattcgatt ttgtcacatc cgatcactat cacgcgattt gcgaaaactg cggtaaaatt 926761 gtggacttcc actacccggg ccttgatgaa gtggagcagc tcgctgccca cgtcacgggc 926821 ttcaaggtaa gccaccaccg tttagaaatt tacggcgtct gccaagagtg ttcgaaaaaa 926881 gaaaatcatt aaaaataagc tgaccgcacg aaacggtcag cttattttat ttcgacattt 926941 tctttttatt ataagactca tcaaattctt ttccttctaa tcccttatct aaagtcagcg 927001 gctctcggca atgcatgcac atatcgacta ctcctaaaac ctttgtctct ttatcacagc 927061 ctggacaaat gacgcgaacc gctttagtcg aaagcattcc gatccaaaag taaactaccg 927121 tgctgagacc gatggataaa agcccaagta tcataaacaa actagaaagc aaaactgact 927181 ctttgaaaaa gatcccgatg tacataatga taaacccaac gaaaaccaaa cttaacgcaa 927241 atgttctgat tttattaatt ttgctggagt atttcgccat gtccatcccc ctctgtttta 927301 actatagcac aaacccgatg ggattttctt catgttttcg gttgaactgg aatttacata 927361 tggagagtta ctgtgaaatt gtttataata gttcaatgtg tttagaaaaa aggaatttcg 927421 ttttaaccat agaattgaat caaatagaga ataaaaaaat ttgaacaatt gcattggagg 927481 aatagtgatg gaaaatcttc tccgtccaat ttaccaagaa agagcaagtc accccaatac 927541 attggctgtc attatgattg agagaagaaa caaaacatct tccttaacag ataactttga 927601 tgcagctttg ctggtgattg taaaggatgc tgatgagcca gtttttataa agcattatga 927661 atttgatcat caaacagctt ctttgcatgt ggtaacagat tctcagattc aagaatggat 927721 tttgcttgga acaaatagaa gaatcataga ttggattgta aatggcagag tcttgtttga 927781 ccgtaatgaa tacgtagttg aactgattga caggctgaat acatttccgt ttgccgaacg 927841 taaactgaag atcggactcg aatacggcaa attaatcaga aggtatgttg aagggaaagc 927901 tttttttgaa gccaatcaat ttttagatgc ctacaatgcc gttgttcatg cgctgcatca 927961 tttagcacgt attgaagtaa tcgacagagg attccatccc gaaaccacgg tgtggagcca 928021 agtgcgccag atggagcccc aagtgtacaa attatattcc gagctgattg aaagtcatga 928081 gagcctggaa aaaagacttg aattattatt cttagcaaat gattttctca tccattccaa 928141 agccgagatc ggttcggcgc atcttttcga agtaatgaaa gaaaaagaca tttggcaatt 928201 cggtgagctt cttcaacatc atgacctaaa gcactttacc caagatcttg gcgttatgct 928261 tgattacttg acggaaaagg gacttatcaa cgtctgccag atagaaacga aaggacaggc 928321 tgtctatcac cgaggatatt cttttaaaaa aggtgttgac tctgattctt gaccgtgtta 928381 tattattaaa cgtcgctgat gcgcttctga gaaaacaagc tcacagcggc gggaaaataa 928441 atcaaaaaaa catttgacaa aagaaagtca aaatgttata ttaataaagt cgcttcaaca 928501 agaagtgaaa atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 928561 taaaaaatcg cacagcgatg tgcgtagtca gtcaaactag ggcctgcacg acgcaggtca 928621 cacaggtgtc gccgcaggat gcggtgaact taacctgtga tccatttatc ggagagtttg 928681 atcctggctc aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat 928741 gggagcttgc tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg 928801 taagactggg ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg 928861 gttcaaacat aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct 928921 agttggtgag gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg 928981 gccacactgg gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc 929041 cgcaatggac gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt 929101 aaagctctgt tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac 929161 ctaaccagaa agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag 929221 cgttgtccgg aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa 929281 agcccccggc tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga 929341 gagtggaatt ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga 929401 aggcgactct ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat 929461 tagataccct ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc 929521 ccttagtgct gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga 929581 aactcaaagg aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc 929641 aacgcgaaga accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc 929701 cttcgggggc agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg 929761 ggttaagtcc cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact 929821 ctaaggtgac tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc 929881 ccttatgacc tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg 929941 aggttaagcc aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc 930001 gtgaagctgg aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc 930061 cttgtacaca ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac 930121 cttttaggag ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta 930181 gccgtatcgg aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag 930241 accttgggtc ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt 930301 cgaaacgtgt tctttgaaaa ctagataaca gtagacatca cattcaatta gtaatacaag 930361 atatcacata gtgattcttt ttaacggtta agttagaaag ggcgcacggt ggatgccttg 930421 gcactaggag ccgatgaagg acgggacgaa caccgatatg cttcggggag ctgtaagcaa 930481 gctttgatcc ggagatttcc gaatggggaa acccaccact cgtaatggag tggtatccat 930541 atctgaattc ataggatatg agaaggcaga cccggggaac tgaaacatct aagtacccgg 930601 aggaagagaa agcaaatgcg attccctgag tagcggcgag cgaaacggga ttagcccaaa 930661 ccaagaggct tgcctcttgg ggttgtagga cactctgtac ggagttacaa aagaacgagg 930721 tagatgaaga ggtctggaaa ggcccgccat aggaggtaac agccctgtag tcaaaacttc 930781 gttctctcct gagtggatcc tgagtacggc ggaacacgtg aaattccgtc ggaatccggg 930841 aggaccatct cccaaggcta aatactccct agtgaccgat agtgaaccag taccgtgagg 930901 gaaaggtgaa aagcaccccg gaaggggagt gaaagagatc ctgaaaccgt gtgcctacaa 930961 gtagtcagag cccgttaacg ggtgatggcg tgccttttgt agaatgaacc ggcgagttac 931021 gatcccgtgc aaggttaagc agaagatgcg gagccgcagc gaaagcgagt ctgaataggg 931081 cgcatgagta cgtggtcgta gacccgaaac caggtgatct acccatgtcc agggtgaagt 931141 tcaggtaaca ctgaatggag gcccgaaccc acgcacgttg aaaagtgcgg ggatgaggtg 931201 tgggtagggg tgaaatgcca atcgaacctg gagatagctg gttctctccg aaatagcttt 931261 agggctagcc tcaaggtaag agtcttggag gtagagcact gattggacta ggggccccta 931321 ccgggttacc gaattcagtc aaactccgaa tgccaatgac ttatccttgg gagtcagact 931381 gcgagtgata agatccgtag tcgaaaggga aacagcccag accgccagct aaggtcccaa 931441 agtatacgtt aagtggaaaa ggatgtggag ttgcttagac aaccaggatg ttggcttaga 931501 agcagccacc atttaaagag tgcgtaatag ctcactggtc gagtgactct gcgccgaaaa 931561 tgtaccgggg ctaaacgtat caccgaagct gcggactgtt cttcgaacag tggtaggaga 931621 gcgttctaag ggctgtgaag ccagaccgga aggactggtg gagcgcttag aagtgagaat 931681 gccggtatga gtagcgaaag aggggtgaga atcccctcca ccgaatgcct aaggtttcct 931741 gaggaaggct cgtccgctca gggttagtcg ggacctaagc cgaggccgaa aggcgtaggc 931801 gatggacaac aggttgatat tcctgtacca cctcctcacc atttgagcaa tggggggacg 931861 caggaggata gggtaagcgc ggtattggat atccgcgtcc aagcagttag gctgggaaat 931921 aggcaaatcc gtttcccata aggctgagct gtgatggcga gcgaaatata gtagcgaagt 931981 tcctgattcc acactgccaa gaaaagcctc tagcgaggtg agaggtgccc gtaccgcaaa 932041 ccgacacagg taggcgagga gagaatccta aggtgatcga gagaactctc gttaaggaac 932101 tcggcaaaat gaccccgtaa cttcgggaga aggggtgctc tgttagggtg caagcccgag 932161 agagccgcag tgaataggcc caggcgactg tttagcaaaa acacaggtct ctgcgaagcc 932221 gtaaggcgaa gtataggggc tgacgcctgc ccggtgctgg aaggttaaga ggagcgctta 932281 gcgtaagcga aggtgcgaat tgaagcccca gtaaacggcg gccgtaacta taacggtcct 932341 aaggtagcga aattccttgt cgggtaagtt ccgacccgca cgaaaggcgc aacgatctgg 932401 gcactgtctc aacgagagac tcggtgaaat tatagtacct gtgaagatgc aggttacccg 932461 cgacaggacg gaaagacccc gtggagcttt actgcagcct gatattgaat gttggtacag 932521 cttgtacagg ataggtagga gccttggaaa ccggagcgcc agcttcggtg gaggcatcgg 932581 tgggatacta ccctggctgt attgaccttc taacccgccg cccttatcgg gcggggagac 932641 agtgtcaggt gggcagtttg actggggcgg tcgcctccta aaaggtaacg gaggcgccca 932701 aaggttccct cagaatggtt ggaaatcatt cgcagagtgt aaaggcacaa gggagcttga 932761 ctgcgagacc tacaagtcga gcagggacga aagtcgggct tagtgatccg gtggttccgc 932821 atggaagggc catcgctcaa cggataaaag ctaccccggg gataacaggc ttatctcccc 932881 caagagtcca catcgacggg gaggtttggc acctcgatgt cggctcatcg catcctgggg 932941 ctgtagtcgg tcccaagggt tgggctgttc gcccattaaa gcggtacgcg agctgggttc 933001 agaacgtcgt gagacagttc ggtccctatc cgtcgcgggc gcaggaaatt tgagaggagc 933061 tgtccttagt acgagaggac cgggatggac gcaccgctgg tgtaccagtt gttctgccaa 933121 gggcatcgct gggtagctat gtgcggacgg gataagtgct gaaagcatct aagcatgaag 933181 cccccctcaa gatgagattt cccattccgc aaggaagtaa gatccctgaa agatgatcag 933241 gttgataggt ctgaggtgga agtgtggcga cacatggagc tgacagatac taatcgatcg 933301 agggcttaac catatttttg aatgatgtca cacctgttat ctagttttga gagaataagt 933361 ttttcaaaaa aacacttgat tttctcaaga atacatagta taatgttaaa tgtcactgaa 933421 attgtctggt gatgatggcg aagaggtcac acccgttccc atgccgaaca cggaagttaa 933481 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac atcgccaggc 933541 agacttcatt ccgcagtagc tcagtggtag agctatcggc tgttaaccga tcggtcgtag 933601 gttcgaatcc tacctgcgga gccattattg gagagctgtc cgagtggtcg aaggagcacg 933661 attggaaatc gtgtaggcgg tcaactccgt ctcaagggtt cgaatccctt gctctccgcc 933721 actgatactt atacataatt acaattgaaa gtctgggccc gttggtcaag cggttaagac 933781 accgcccttt cacggcggta acacgggttc gaatcccgta cgggtcatta tatgatggag 933841 gattagctca gctgggagag catctgcctt acaagcagag ggtcggcggt tcgagcccgt 933901 catcctccac cattatatca tcgcggggtg gagcagttcg gtagctcgtc gggctcataa 933961 cccgaaggtc gcaggttcaa atcctgcccc cgcaaccaaa ttttaaaatg gtccggtagt 934021 tcagttggtt agaatgcctg cctgtcacgc aggaggtcgc gggttcgagt cccgtccgga 934081 ccgccatttg aatacttagg ctcggtagct cagttggtag agcaacggac tgaaaatccg 934141 tgtgtcggcg gttcgattcc gtcccgagcc accacctatg ccggtgtagc tcaattggta 934201 gagcaactga cttgtaatca gtaggttggg ggttcaagtc ctcttgccgg cactgttttt 934261 tcaaaattta atgtggaggg gtagcgaagt ggctaaacgc ggcggactgt aaatccgctc 934321 cctcagggtt cggcagttcg aatctgcccc cctccaccat ttataggggc atagtttaac 934381 ggtagaacag aggtctccaa aacctccggt gtgggttcga ttcctactgc ccctgccaaa 934441 tttatgacat cttgagatta tggcggttgt ggcgaagtgg ttaacgcacc agattgtggc 934501 tctggcactc gtgggttcga ttcccatcaa tcgccccata ttatcattgg gctatagcca 934561 agcggtaagg caacggactt tgactccgtc atgcgttggt tcgaatccag ctagcccagt 934621 ctcacttttt atatcaactg catataatgt attaagtcca ttaaaaatgc ggaagtagtt 934681 cagtggtaga acaccacctt gccaaggtgg gggtcgcggg ttcgaatccc gtcttccgct 934741 ccaattacgg cggcatagcc aagtggtaag gcagaggtct gcaaaacctt tatccccggt 934801 tcgaatccgg gtgtcgcctt cttattgccg gggtggtgga attggcagac acacaggact 934861 taaaatcctg cggtaggtga ctaccgtgcc ggttcaagtc cggccctcgg caccaatttt 934921 acttacatgg taagttgaat tggtgtttgt gttttatcat tataactaat catattaatg 934981 atctacataa gtagatcatt tttttaatgc tttgatttat cataacaagt taagttccga 935041 ggcctattat aaagcggctg tatagctagt ctttcaacac ttttatttta tatttccata 935101 aaaacttttt tgaaatacgt tgacacttta tgagatccat gatatattta tattcgtcgg 935161 ttagatacga cgtaaaactt gccggtgtgg cggaattggc agacgcgcac gactcaaaat 935221 cgtgttcctt ctggagtgtc ggttcgaccc cgaccaccgg tatactgaaa aacccgtttc 935281 ttaacagaaa cgggttttta ttttttatta aagaaaagga gcctcggctc ctttttatac 935341 ttactcagcg tattggtcta ggatctcttc tagcacctct tctagctctt ctgtatcttc 935401 aagctctgat tggctgaaac ggacgcgtac aagctgttct ccgtcattat acatctcttc 935461 caaccaccct cggagtcctc ttgctctgcg gtcgacttcg aaaatgattt ccaaaccgtc 935521 ttcgtctaaa aggaaaatga gctctaattc atcaagcatc tgacgataat atccggaagt 935581 cggaacgaat tcgaattctt gaacgaacgg aagacgacgc tggaagtagg gcgcttgttc 935641 gcagtctgct tcgttaagac ggaagcccag gttttcgatt gcttcaagca cattttcaat 935701 ccaagggtgc gcttcaacga aaatgcggtc atgatcggat ttatcgatac cgccttgaat 935761 gtcaaggtct gtcaccacgg caacctctac tttccctaca gtgatcggcg tatctagagg 935821 cagagtgaat gtgaacggaa attgatgctc ttcaccaggc tgtatggtaa atgaaccagt 935881 gacccggaaa gaatgaattg tagcgtattt ccggtgctct tcatcgtctt ttacaatgac 935941 ataccgtgtg ctaagctgta aatcgatata acggatgtcc tgagcgattt ttccgccttt 936001 gacatgtacc gttccctgta cttcttctcc tggaaaatat gcgtcttttt ctaaaattgt 936061 atctactttt gcagctccaa ttccggcact tgccgcaagc ttcttaaaaa atgacatgtt 936121 agatcttccc ctttttcttt tttctcaaca gatatacgta agaaggagga aaaaagattc 936181 gtttgattca tacttttttc ctattattcg tctcggccta gggacagact aagaataata 936241 ttgaaaataa aggagtcgat ggaagtgaat aaagaaagtt tggttgcaga tgaattacac 936301 agaatgtttt tggctggtga gctgcaaatc acagtagagg aggatataaa caatatttcc 936361 gaaaggctga gaaacggcga tctcagttta gaccgattaa gcggtgaaga cgtgtttata 936421 aaagaaacgg taaatgaggc tttaagaaga gtggagcaat aaaaaagaga cggcatctca 936481 tctttgagat cccgtctctt tttgtggtct ttgctgtaag ataaaagcga atcgatttgg 936541 aattgctcac ccgagccacc ccttttctaa cagaagatct gacagttcat catggagata 936601 aacagctgta tctaattgat catgcaatgc tcttctgatg tggggatttt cggttgctgt 936661 tgttgcgaca gtgtatttgt taatgctggt ttttattgtt gttaacaaat caagaatatc 936721 tttgggacaa agactttgtt caatgggaaa ccacctcctt tgttttttta gcagctcctg 936781 ataagaaagt atttgacttt gtttcttgct tctatacaaa atgctataat aagcaacaaa 936841 ttttgttggg gggtgtgatg atgaagcaga ttattgcgat ggggggcggg ggtttttcga 936901 tggagccgga taatttgtcc ctcgatcaat atatcctcaa tcaatcaaaa cgagagcagc 936961 ctcgtatttg ttttttgccg acggcgagcg gagattccca aaactatatt cagcggtttt 937021 atcatgcatt tcaaacattg gattgcgtgc cgtctcattt atctttgttt aagccaccat 937081 catcagattt agtttctttt gttatggaaa tggacgtgat ttatgttggc gggggaaata 937141 cgcggaattt acttgtgtta tggaaagagt gggggctgga ccatattctc agggaagcat 937201 ggaagaacgg tgtggttgta gctggaataa gtgccggtgc gatctgctgg tttgaagaag 937261 gggtgacaga ttcagccgga ccgctgacaa gtttgaaaag tttaggtttt ttgcaaggga 937321 gcttttgtcc ccattatgac ggggaaaagg atcggagacc ggcataccac cagctgatat 937381 ctaacaagtt cttatgcagt ggctatgcag cggatgatgg ggctgctctc catttcataa 937441 atgatcagct gtttcagact gtgagttcaa ggtcgggtgc aaaggcatat cgggtgatga 937501 tggctgaaca tgaaatagct gaaatcccgt tgccggtcaa atatttaggg tgaaattggc 937561 tgaatattat ctatattcct ctttttttca gattgatttt atgataagat gagtgcgaaa 937621 tcaatagtta ctgggggtgc ccgctttcgg gctgagagag aaggcaagct tcttaaccct 937681 ttggacctga tctggttcgt accagcgtgg ggaagtagag gaattgtttt tgttattgtc 937741 ttgctgggca ataatatgtt tctttctgac tgtaaccggg ttcatttata tgaatccggt 937801 tttttgtgct ggttatgggc ttgattttgt cctttcaaac gtagaaaggg gaaggaaaag 937861 taatgcaaaa caattcagtg cagcaagcca acatttccat tatgtcaagt ttttcaggca 937921 gcaagaaggt atacgtggag ggttcttctt cggacatcca agtgccgatg agggagattg 937981 cattgagtcc gacgacggga tcgttcggcg aagaggaaaa cgcgcctgtg cgtgtctatg 938041 atacaagcgg accgtatacg gaccctgaag taaccattaa tattcaagaa ggattaaagc 938101 cgctccgcca aaaatggatc acagagcgcg gtgacgtgga agagtatgaa ggtcgggcta 938161 taaaaccaga agataacggt tataaaaaag caaaaccaaa cgtaagctat ccaggattaa 938221 agcggaaacc gctgagggcg aaggcaggtc aaaatgtcac acaaatgcac tatgcaaaaa 938281 aggggatcat tacacctgag atggaattta tcgccattcg tgagcatgtg tctcctgaat 938341 tcgtcagaga cgaggtagcc agcggccggg cgattattcc ttcaaacatt aatcaccctg 938401 aaagtgagcc aatgattatc ggccggaatt ttcatgtgaa gattaatgca aatatcggga 938461 attcagcggt tacgtcatcc attgaagaag aagtggaaaa aatgacgtgg gccatccgct 938521 ggggagcgga tacgatgatg gatctctcta ccggaaaaga tattcatacg acgcgtgaat 938581 ggattatccg caattgcccc gtgcctgtgg gaactgttcc gatttatcag gcgcttgaaa 938641 aagtaaacgg cgtagctgag gatttaacgt gggagattta tcgtgatacg ctaatcgagc 938701 aggcagagca gggagtggat tattttacga ttcacgcggg tgttttgctt aggtatgtac 938761 cgctgactgc caaacggaca actggtatcg tgtcacgcgg gggagcgatt atggcgcagt 938821 ggtgtctggc tcatcatcaa gaaagctttt tatacacaca ttttgaagaa atatgtgaga 938881 ttatgaaaat gtatgatatt gctttctctc ttggggatgg tttgcgtccc ggatcaattg 938941 ctgatgccaa tgacgaagcg cagtttgctg aattagagac gcttggagag ctgacgcaaa 939001 ttgcctggaa gcatgatgtt caggtgatga ttgagggtcc tggacatgtt ccgatgcata 939061 aaatcaaaga gaacgtcgat aaacaaatgg acatttgtaa agaagcgcct ttttacacat 939121 tggggccgtt gacaacggat attgctccgg gatatgacca tattacttca gcgatcggag 939181 cggcgatgat cggttggtac gggacagcaa tgctttgtta tgtaacgccg aaggagcatt 939241 tggggctgcc aaaccgtgat gatgttcgtg aaggagtcat tacatataag atcgctgcgc 939301 acgctgcgga ccttgcaaaa gggcatcccg gagcgcaaat ccgggatgat gcgttatcga 939361 aagcccgttt tgaattccgc tggcgggatc agtttaattt atctcttgat ccggagagag 939421 cccttgaata ccatgatgaa accctgcctg ctgaaggagc aaaaaccgct cacttttgtt 939481 ccatgtgcgg tccgaaattt tgcagcatga gaatttcaca ggatattcgg gattatgcga 939541 agaaaaacga tctcagtgaa gcagaagcca taaataaagg attaaaagaa aaagcaaaag 939601 agtttgtcga tacgggaagc aatttatatc aataaaaaaa atgaagatgg agaatgctcc 939661 atcttcattt ttttagaaaa acagagagcg tcgaagcgga ggaatactct gttcaaagcg 939721 gaaaacattt tctggatcat atgtcgtttt gacacggcgg agtcgttcaa cgttttcgcc 939781 gtaatatgtt cttggccagt ttctgatttc gatatctggc caatttacgt agtctcccat 939841 cgtttctttc gaaagggacg ttctcagccc ctcaatccag cggacatttt gtcttttttc 939901 tccaggggat gtccagtttg ttaagtattc ctgggcgatg attgcgtcac gataataaaa 939961 tgccgtttgg tcgggagcga cccgtccggc tgccccgccg agtgcttgct gccagacact 940021 ggcgttttga ttcggagcgt gctctaaaaa gtgttttatt gttgagatcg cacgttctga 940081 taatggcttt tcaatgaaag agccggagcg tttcattttt tgaggctgat tgcctcccgg 940141 gctgttaaaa aaggttaccg cttcaatgaa tggcgttgtt tttaccattc cgcttgtcgg 940201 acttcctgct ttcaataaag gctttaacag tttttttaac tctgtttttg gcccgacaaa 940261 ttggccgagg gcttctatgc ggtttacttc tttaggccaa aactctattg atgatgtaag 940321 ccggtcatct gtatacgggg cccagttctg ccacgtgtta tatacttcct caaaatcatc 940381 ccatccccat gtaatagaaa aaatcgacac ttgagagatg ggcactgctt taaatgtcat 940441 ggaggtgact atgccgaaat tgcctcctcc gcctccctga gacgcccaaa ataagtctgg 940501 atgatttgaa cagctgactg taatcagatc agcgccctct ttttcgtctg ctacgatcat 940561 ctcaagctgc acgaggctgt cgcaagtaag accggcagcc cttgttaaaa gtccaattcc 940621 ccctccgaga gttaaacctg tgagccctac attagcaatg gtgcctgcgg gaagcgtcag 940681 gccgtattgc cagagtgtcc gatagacttc tcccaattca gcccccgctt caatataggc 940741 cagcttttta tcctgattca cagttatttt tttcatctcg cttaaatcaa taacaagacc 940801 gttatttaaa agggaaaagt tctcatagct gtgtctgccg cctctaatac ggaaaggcac 940861 acggttttca cgcgcccatt tcagcgcatt gagtgcatcc tgtttgtttt ggcaaaacac 940921 aatgatgtca ggataccttt ctaagcttag gttaatattg gttcttgctt cgttatagtc 940981 cggatcatcc cgtgtcacga tacgtccggt caattttgtc ttttccacac tcccacatct 941041 ctttctctcg tattctagtt tctctagctt atgcgtcagg ggaaaagagt gtataaggaa 941101 aaagcgggga tgcaatctga tacagtgtca acaccctcaa aaaatagttg acaggtcggt 941161 attgtatgaa ttaacatggt cagtacaaat ttttcaaatt tatcgcgctg atcggaacac 941221 cgaaggctct tatcgtttag ataagggcct tttttgtatg aaaaaggggg gattattgat 941281 gggagtcaaa aaagaaaagg ggagaaaacg attcaggaag cgaaaaacct acgggaatca 941341 gattttgccg cttgagctgc tgattgaaaa aaacaaacga gagattataa acagcgcgga 941401 actcatggaa gaaatttata tgaagattga tgagaagcat acgcaatgtg taactaaata 941461 taaaaaaacc cgctgactac aacgggtttt tgcatttctc cattaagaat cttttttaat 941521 cggcaatcca aggccttctg ccacgcgttt tccgtattca ggatccgctt tgtagaagtg 941581 ctcgatttgg cgcagcttga tttcttcttt ttctaccggc ttcatggcat taacgatatt 941641 ttcaacaagg cgggtacgtt catcttcact cattaaacga tacagatcgc cggcttgagt 941701 gtagtgatcg tagtgatcgt agcttacgct gtcagcgata ccttgtaccg gatatgctgc 941761 ttgcttatcc tcaggtgact cttttggacc gccgaagctg ttaggctcgt aatacacaga 941821 tccgccgccg ttatcatcaa aacgcatttg cccatcacgc tgataattgt ttactttgtt 941881 gcgtgcgcgg ttgattggca gcgcttgatg gtttgcaccg acacggtagc ggtgtgcatc 941941 atgataagca aaaagtcgac cttgaagcat tttatccggt gaaacatcaa taccaggcac 942001 gagggttcca ggtgaaaatg tcgcttgttc tacctctgca aagtagtttt ccggatttct 942061 gtctagaacc atgcgtccga cctcgattaa cgggtagtct ttttgagacc aaacttttgt 942121 gacatcaaac ggatcgaaac ggtacgtatt tgcatcttct aaaggcatga tttgcacata 942181 tagtttccat gcaggataat caccgttttc gattgcgttg aaaaggtctt ctgtatggta 942241 atcagggttt tcaccggcaa tttttgctgc cgtattgaca tcaaggtttt tcacgccttg 942301 ttctgtttta aagtgatatt taatccatac gccttcgcct tcggcatttg tccatttgaa 942361 tgtatggctt ccgaagccgt gcatgtggcg aagtgtcgca ggaattccgc ggtcagacat 942421 caggattgtc acttggtgca gtgactctgg tgaaagtgac cagaaatccc atacagccgt 942481 agggtttttc aggtgtgttt ttggatctct tttttgtgta tggatgaaat cagggaactt 942541 aatcgcatcg cggataaaga atacaggcgt attgttgccg acgatgtcgt agtttccttc 942601 ttcagtataa aatttaacag caaatccgcg cgggtcgcga actgtgtcag cagagccaag 942661 ttcaccggca actgttgaga aacggatgaa caacggtgtg cgtttgccga cttcagaaag 942721 gaaagcggct ttcgtgtatt ttgttacgtc gtttgtcact tcaaaatatc cgtgtgcgcc 942781 tgctcctttg gcgtgaacaa cacgttcagg aacacgttct cggttgaaat gggccaattt 942841 ttcgagtaaa tgtacatctt gaattaaagt tggtccgcga gaaccggcag tcattgagtt 942901 ttgattatct ccaaccggag cgccccagct agttgtcagt ttatttgaac tcatgttatc 942961 acctcttgga atttataaga acataatatc atctctaagt aaaaagtcaa tattatttta 943021 taattattat aaaatagtta tctctattaa tcgatatata gtatcgaaat tgttgaaaaa 943081 ccttgttgta acagcttttt atgacactta ataatttttg gagaaataat ttttccttct 943141 ctatttgcga aacaagcaga gtaagtgata aacaaggata tcaaaaatcg tatttaaaaa 943201 agagttgaca tatcggaata atttgaatta acatgttatt caaacaaaaa aacaattggg 943261 cagctgatcg gaccgccgaa ggctctcatc tctacaagaa cagagatggg ggcctttttg 943321 ttttttttga aggcggggtt ggcagaaaga gagggataaa agtggctgtg accatcagca 943381 tcaaagaaaa ggcatttgtt caagaaggcc gcaaaaacac ggtcttagaa aacatagaat 943441 tatcaatcgc accaggcgaa tttctaacgc ttatcggacc gagcgggtgc ggaaaaagca 943501 ccctgttaaa gattattgca gggcttgatt ctgaatatga cgggagtgtg gaaattaacg 943561 gccgcagcgt aacagctccg ggtattcagc aaggatttat ttttcaggaa caccgcctct 943621 ttccttggct gactgttgag cagaatattg cagccgactt gaatttgaag gacccaaaag 943681 tcaaacaaaa ggtggatgaa ctgatcgaga ttgtcagatt gaaaggatcg gaaaaagcat 943741 atccgcgcga gctgtcaggc ggcatgtcac aaagagtagc catcgcccgg gccctgctgc 943801 gggagcctga ggtgctgctt ttagatgaac cgtttggtgc actcgacgct tttacaagaa 943861 aacacctgca ggacgtgctg ctggatatat ggaggaagaa aaaaacaacg atgattctcg 943921 tgactcatga tatagatgaa tctgtttatt taggaaatga gcttgcgatc cttaaggcca 943981 aaccggggaa aatccataag ctgatgccca ttcacctggc gtatccgcga aaccggacga 944041 ctccggattt ccaagcgatc agacagagag tgctgtcgga attcgagaaa acagaagatt 944101 tggagtacgc agaaggatca gggatataga aagggcggaa gcggaaatga aaaaaggact 944161 cattgtattg gttgccgtta tttttctgct cgcaggctgt ggagcaaatg gagccagcgg 944221 tgaccacaaa caattgaagg aaattcgtat tggtattcag caaagcttaa gccccctttt 944281 gattgcaaaa gaaaaaggct ggttcgaaga tgcatttgaa aaagaaggca tcaaagtgaa 944341 atgggtggag tttcaaagcg gtccgcccca atttgaaggc cttgcggcag acaaacttga 944401 tttttctcaa gtcggtaatt cgcctgtgat cgctggacag gcggcaggca ttgactttaa 944461 agaaatcggt ttgtctcagg acggcttgaa agcaaacggc atccttgtca atcaaaacag 944521 cggcattcaa gacgttaagg gcttaaaggg gaagaaaatt gcagtcgcca aaggcagcag 944581 cgggtttgat tttttgtata aagcgcttga tcaagtgggg ttgtcagcta acgatgtgac 944641 aattattcag cttcagcctg atgaagcagc ttccgcattt gaaaacggat ctgttgatgc 944701 ctggtccatt tgggagccgt acttgtcctt agaaacaatg aaacacggag caaaaatcct 944761 tgtgaacgga gaaagcacag atttatattc accgggtttt actttagtaa gaacaaagtt 944821 ttcagaagag catccagacg aagtggtccg ttttctgaag gtgtttaata aagccgttgt 944881 atggcaaaag gaacatctgg atgaagcagc ggacttatat tctgacatta aagatctcga 944941 taaaaaggtc gtcgaaaatg tgctgaaaaa tactgagcca cttaatgaga tcatcagtga 945001 cgacattgtg aaagcacagc aggaaacagc agattttcaa tttcgaacaa aggcgataga 945061 taagaagatt gatgtgaagg atgttgtcga taacactttt atcaaaaaag cattagagga 945121 gcattcctca ggaggtgatc aatgatgaaa gcagaggctg cgggctcgct gcccaaaacg 945181 aatgcggaag cggtgcgaaa aaagcccgga aggaagagat acggctggat gaaggggctt 945241 ttactgcccg ctgtcatcat tgccatctgg caggtcatcg gcgggctggg ggttgtgtcc 945301 gctacagtgc tgcctacacc tgttacgatt gttctgacct ttaaggagct tattttgtcc 945361 ggcgaactgt tcggccatct gcaaatcagc atttatcggg cggcacttgg ttttttgctt 945421 ggcgcggggc ttggattgat gatcgggatt ttggccggat tttccaaacg gacggagctg 945481 tatcttgatc cgtcgttgca aatgcttaga accgtacctc atctggccgt cacgccgctg 945541 tttattttat ggttcggatt tgacgaagta tctaaaattt tgctgattgc gctcggtgcc 945601 ttctttcctg tctatatcaa tacgtttaac ggcatccgcg gggttgacgc gaagctgttt 945661 gaagtcgccc gggtgcttga atttaaatgg catcagcaga tatccaaagt gatattgccg 945721 gcagccctgc ccaatatatt gctaggcatt cgcttatcgc tcggcattgc atggctcggg 945781 ctcgttgtgg cagagctgat gggctcaagc tcgggagtcg gctatatgat catggatgcg 945841 agacagtttt cacaaacgaa taaagtcttt gcagggatta tcatttttgc agtggttgga 945901 aagctgacgg attccttcgt caggctgctt gaacgaaagc tgttaaagtg gagaaacagc 945961 tacgaaggat aaaagatata aaggggagat gaatatggaa attctttggt ttataccgac 946021 tcatggagac gcgagatatt taggatctga aagtgatgga cggactgcgg atcatcttta 946081 ctttaaacaa gtcgcgcagg cggcagacag gctgggatat acaggagttc ttctgccaac 946141 gggaagatcg tgcgaggacc cgtggcttac agcgtcggca ctggcaggag aaacaaagga 946201 cttaaagttt ttagtcgcgg taagacctgg tttaatgcag ccttctctgg cagccagaat 946261 gacatccacc ctagaccgca tttcagacgg ccggctgctg atcaacgttg tggcaggggg 946321 cgatccgtat gagctggcag gcgatggcct gtttatcagc catgatgagc gctacgaggc 946381 aacagacgaa tttttaaccg tttggcggag acttttgcag ggagaaacgg tttcctatga 946441 aggaaagcat ataaaagtgg aaaacagcaa tctgcttttc ccgccgcagc aagagccgca 946501 tccgcccatc tatttcggtg gttcgtcaca ggctggaatt gaagctgccg caaagcatac 946561 agacgtgtac ttgacatggg gtgagccgcc tgaacaagta aaagaaaaga tagaaagagt 946621 caaaaagcaa gcggcaaaag aagggagatc cgttcgattt ggcattaggc tgcatgtcat 946681 tgcccgtgaa actgaacaag aggcatggga agcggcagag cgcttgatca gccacttgga 946741 tgatgacacc attgccaaag cgcaggcagc tttgagccgt tacgactctt caggccagca 946801 gcggatggcc gtccttcatc aaggcgatcg gacgaagctt gaaatcagcc cgaatctgtg 946861 ggcggggatc ggcctggtca gaggaggggc aggaacagct cttgtcggtg atccgcagac 946921 gattgccgac cggatagcgg agtaccaggc actcggcata gaatcgttta tattctccgg 946981 ctatccgcat ttagaagaag cgtattattt tgcagagctt gtatttccgc ttttgccgtt 947041 tgaaaatgat cggacgagaa agcttcagaa caaaagggga gaagcggtag gaaacactta 947101 ttttgtcaaa gagaaaaatg catgagttta actaaaatac agccccccga acatggtatg 947161 atattcaaaa aaagggggct ttttttctga aaacattgag aagcgcggca gtcatttgcc 947221 tcatagctat gctgtcagca tgcggacatt caaaacagat ggaaatcaaa gcggcggaca 947281 tatcagatct tgaaaaaaac agaatggatg tcgcagcttc acaggcattc actgccgaag 947341 ccgtcaatat cggtgaaggt atttcttcag ctgacatgta catcgaacat tatcaaaagg 947401 gaaagcttgt tgagaggttt ggaccggttc gtgcagatta ttcagaggaa aaaactgata 947461 ccatacaatt tgtttatttt gagaatgaag agggggaagg aaagaataaa cataccacca 947521 ttcattttgg cattgtggat aaacagggaa ctatagcggc tgattcatcg gtgaaacgcg 947581 acgatagcac aacacaggaa atgactcaga atatttcatc gccggaaccg attactttcg 947641 agaagcctgc tttgatcggc agcagtatta gagggactga cgagacaatg cacacctctg 947701 aacataaaaa agagctcatt aagcatcaag atgcgttact gtattatgtg gaattgcatc 947761 attagaatgg gcggcttcag gccgtctgtt ttacaaagcg gtatgcttgc ttttttgaat 947821 ggtgaatgat acattttaaa tcgtaacaat ttcgatttaa agggaggcta tgtgacttgg 947881 ctaaaaaatc aaaagtggca aaagagttaa aacgccaaca gcttgttgag caatacgctg 947941 gtattagacg cgagttgaag gaaaaaggag attacgaggc actcagcaag ctgccaagag 948001 attcagcacc gggaaggctt cacaaccgct gcatggtaac ggggcgcccg agagcatata 948061 tgaggaagtt taaaatgtcc agaatcgctt tcagggagct ggcccataaa ggccagattc 948121 ccggtgtgaa aaaagcaagc tggtaagaaa aaactccggc cgattacagc gcgccggagt 948181 ttttttcgtt tttcttgaaa gagatgacgt aggaaaggtg ctggatgatc atgatgataa 948241 acacaataat aatagggaaa aacggaatgc gcgattgaaa tagcggataa aaaatgagaa 948301 gaaccgctgc ggcaggcagc gagaagtaga cagcgatata tgacgcgcga catgcttttg 948361 ccgtcatcat ctgctctctt tcatcctgct cttcaaactc atcaggcaga agtagctgct 948421 ttctggcagg gcggcttttt ttctgtaagt acaaataaac cgcagacgcc gcaacaaaca 948481 gaataaaggg agtgaggttt aaatcaaata ccatcccgcc gctctttgtg ccgaaaaaag 948541 atgctatgcc ttctgaggct tcaaagtatg aaatcagcgc ccagcatgca aggccaaata 948601 aaacaaggtg aaaagctgct tttgttttca tgctcatctt agttttcctc ctctaaccaa 948661 aagacatcct ccattttcat ggagaaggct ttgcagattt tcagtgctaa cagcagtgag 948721 ggaacataat cgcctttttc aatcgctgcc acagtctgtc ttgtgacgcc gaccgtttct 948781 ccgagttttt cctgagaata gccgaagcgt gccctcagct cttttacttt atttttcatc 948841 atgacgtctg tccccttcac aatctcgatt gattatattg tatagtatac ttaacattat 948901 gtaaatggaa cttaacaact ttacaaaaag ataacttttt ttcgacaaaa tttttatatt 948961 cccttgacga aaaataaata aacatgtaat ataaaaaaag tcagagcggt actgttgctg 949021 acaatcacaa atgcgggtgt agtttagtgg taaaacctca gccttccaag ctgatgtcgt 949081 gagttcgatt ctcatcaccc gctccataca tacgttatta acgcagtgtt tcgtttctca 949141 gataaacgaa gtattgcgtt tttttatgtg aaaaagaaca cggtattcgt gttcttttac 949201 gtaagccaat gtactgtatg ggtgccgccg tgaatttgtt caaacatttt cgttaatgat 949261 gataagaggt taacagcgct gcttttctca atcgatggcg ggaaaaaaat gatttgcagc 949321 atattcttag tctcgtttga aacgggatag tggttgacgc tgtttttgaa atcgccaaaa 949381 atgccgtttt catcagagaa aagcagtatg ttttcttttt ctcccaatga gatccggacc 949441 ggctcatgaa gctttccggc atcataaatc ataataggca gagaatattt taatgcgaaa 949501 aaatcgattg tgtcatgggc cgagtcttta ctttccatga attgttcctt ggatatcggg 949561 accagcatgt cctccattgg ggttgtttct ccctcaaatg aagggttaag ctgtttaaag 949621 agtttctgcc attccttgac gaaggattca tcggatatac cgccgtccgc atagtcgaaa 949681 aacaaggatt cttgaaacag gcggagtctg cctttcagca tttgcggtga ggagccgact 949741 tcgatattct cataaatgac agcagctgca tgtaagccgg ccgcacgttc agtaataaca 949801 gaatcaagtt tgatattcac tagcattcac tccagttacg tgatatcaac ctattataaa 949861 cgctgtgtcg ttttatcaca aagaaaggag gctgtgcaaa acatgaacgt ttatcagctc 949921 aaagaagaat taattgaata cgcgaaaagc attggcgtag acaagattgg ttttacgacc 949981 gctgatactt ttgacagttt aaaagaccgt ttgattcttc aagaatcact cggctatctc 950041 tccggctttg aagagccaga tatcgaaaaa agggtgacgc cgaagcttct tttgccgaaa 950101 gcgaaatcaa tagtggcaat tgctctcgca tatccttcca gaatgaagga tgcgccgaga 950161 agcacgagaa ctgagcgcag gggcattttt tgcagagctt cctggggaaa agactatcat 950221 gatgtgctga gggaaaagct tgatctgctg gaggattttc taaaaagcaa gcatgaggat 950281 atcagaacga agtcaatggt tgatacaggt gaattgtctg atcgcgccgt tgcggaacgt 950341 gccggaatcg gattcagtgc gaaaaactgt atgatcacaa cacccgagta tggctcttat 950401 gtgtatttgg cggaaatgat cacaaatatc ccttttgagc ctgatgtgcc gattgaagat 950461 atgtgcgggt cctgcacgaa atgcttggac gcctgcccaa cgggagcact ggttaatccc 950521 gggcagctta atgcgcagcg ctgcatctct tttctgaccc agacaaaagg atttttgcct 950581 gatgaattcc ggacaaaaat cggaaaccgc ctgtacgggt gcgatacgtg ccaaacggta 950641 tgccctctca ataaagggaa ggattttcat cttcatccgg aaatggagcc tgatcctgag 950701 attgccaaac cgttattgaa gccgcttttg gccatcagca atcgggaatt taaggagaaa 950761 ttcgggcatg tctcaggttc ttggcgcgga aaaaaaccga ttcagcgaaa cgccattctc 950821 gcgcttgccc attttaagga tgcttccgca ctgcctgaat tgacggaact gatgcacaag 950881 gatccgcgtc ctgtcatcag ggggacagcc gcatgggcaa tcggaaaaat cggagacccc 950941 gcctacgcgg aagagcttga aaaagcgctg gaaaaagaga aggatgaaga ggcaaagctg 951001 gaaattgaaa aaggaattga gttgctaaaa gcttcaggca tgactaaaca aggcctgtcc 951061 tgacatacgt atagagcaga aggaaaaaac acttgagatc atccaagtgt tttttctcta 951121 taaaaaagta tggcgggtgg ggtgagcttg aagtacattt tagaacaatt agcggaggag 951181 cggctgggct ttctggttaa cgggcatgct atgagacagg agtctcaagt cggagacctt 951241 aaagtcatgg agcgtaagaa aaagcttctg gaaaaacgta aagttgacat cataaaagcg 951301 aaagcaaagg ccgtgattaa tcatgtgcgg gttgaggatg acggaacgac ctgcctttcg 951361 tataccatcc attacgaata cgtgtgtaag gaacaagatg acagcttgta tatagaagag 951421 cacatagagg agcgaatggc tttcctgtat gatcacattt tgattagtga tcaggaaatt 951481 gcgaaaaagc cggctggatt tcatgaaggg accagtatta ttgactattc tgaagctgaa 951541 gaggaaagag aagcgtttgg cagggctttt caatacgatc gtctcggcgc tgtccaatat 951601 gccgagaaat tttggaacaa gcgcaatcct gcttataaaa atttcagcga taactgtaca 951661 aattttattt ctcagtgtct tcatgcagga ggcgcgccga tgcgcggtca tccgaacagg 951721 ggatcaggct ggtggatgaa acaaagctca tggagctaca gctggacggt ggctcactct 951781 atgaaaatgt atttgtcgaa ttcaaaggcc ggactgcgtg cggtgcgggt gaaatcagcg 951841 gaagaactga tgccgggcga tgtgatttgc tatgacttcg aaggagacgg ccggtttaat 951901 catacaacga ttgtcgtggc aaaggacaaa ggcaatatgc cgcttgtcaa cgcccagact 951961 tatgacagca ggatgaggta ttggtcatat gaggattcta cggcatacac gccgtcaata 952021 cgatatgcct tttttcatat cgttgatgat acgacaaaag agtaattaat gttataatga 952081 tgggcggata agaaaaacag aggtgaacat tgtggcatta catgtcgttt tatatcaacc 952141 agaaattccc gctaacacag ggaatattgc acgtacttgt gcagcaacca atacaacgct 952201 acacctgatt cgtccgctcg gcttttcaac ggatgataaa atgctgaagc gtgccggact 952261 cgattattgg gagtttgtta acgttgtgta tcatgattcg ttagaagaat tgtttgaggc 952321 atataaaaaa ggcaagtttt tctttattac aaaatttggc cagcagcctc atacatcatt 952381 tgattacact gatcttgacg aggattattt cttcgtgttc ggaagagaaa caagcggttt 952441 gccaaaggat ttaattcaaa ataatatgga ccgctgcctg cgtcttccga tgacagagca 952501 tgtcagatcg ttaaatctgt ccaatactgc cgcgattctt gtttatgaag cgctgcgcca 952561 gcaaaattac cgtgatttaa aatagtgaaa aacccgctca tcgatgatgg gcgggttttt 952621 ttgcggatgt tgaaatgctt tgtttcgttt ttgggcttaa caacgtaaca gtgttatgtt 952681 acaatgtacc catcaaagga gctggactta tggaagaaca attaatctct aaaaaagaat 952741 tacttgaaag aacatcgatt tcatacggtc agctgtatcg atggaagcgg aaaaacttaa 952801 tacctgagga atggtttatt cgtaaatcca catttacagg gcaagagacg ttttttccga 952861 gagaggagat tttaaaacgt atatcaatga ttcaaaagat gaaagaaaat ttgtctttgg 952921 atgaaatgag ggaaatgctg tcgccgaaaa tgaaggatgt cagcatgacc gctgatgaat 952981 tgcttcataa aggtttggtt tcaaggcctg ctcttgaagc ctattcagaa gacggaggaa 953041 gtccggtttt ttcatccagc gatttgcttt cgctgtttgt gcttgagggc ctgctgcagt 953101 ctggaaatgt cagccttgca gaagcaaaaa tggctgcaga ggtattaaag aagcatgata 953161 ctgaagagat tgaaaaacag acggagctga ttgtgctccg caagctcggt gtcacaactt 953221 gttttatagc ggctgcggcg gacagcattt tgtttgaatc atccgtaaag gttgtggaac 953281 gggtagattt attaaaagct tcagaggaat taaaaacaac atttatgcag gagggccatc 953341 aatggatgta gtggaaaagc tggtgataaa tggatcagga agttctaagg gaggaacatt 953401 tcaatcagtt gagattaatg gcagcgggac agtggccggg gacgtggagt gtgacacttt 953461 ttcttttaat ggaaacggaa aagcggacgg cagcgtcaaa gcgaaagcgg taactatcag 953521 cggttcagga aagatacatg gagacgttga agcagaatct atccggatga atggcactgg 953581 ttttattcaa ggagaggtat ctgcaaaaca attgaaaatc gctggatcat caacatttgg 953641 cggcactgtc aaggctgatg gaattgacat tagcggaaaa gctgtcatgg aagcagattg 953701 tgaaacagaa acctttcaat cagaagggaa atgcaaaatc agcgggcttt taaatgcaga 953761 ccaggtgatc attaagcttt ctgcagggga aagctatgcg cgggagatcg gctgccgcca 953821 tcttcaagtg acctgcagaa aaggaatgct gacattgctc agattgatgc cgcagcctgt 953881 tctaacagca gagctgatcg aaggtgacgt gattgaattg acaaatacaa aggcgaaaac 953941 cgtgcgcggt aataaagtga tcatcggccc ggattgccag attgaaaccg tcgaatacag 954001 cggggactat acctgtgatc caagcgcgtc ggttgaaaca tccacaaagt tgtaaggagg 954061 atcgtaatgg agacaacaaa actgggaaat ttaaaattat atggcgctgg gcatgccgca 954121 ggaggcgcgt atcacaatgt cagcatcaaa ggagaaggta tagttggaga agggctgtct 954181 gctgtaggct gccgcatata cggaacgggc ctttttctcg gaaaagcaga gactgagcgg 954241 ctgcgtgtgc tcggagaaag tgaatgtaaa ggcgatctga cagccggcaa aatcaatata 954301 tatgggacaa tgaaagtcag cggctcactt caatttgatc gattcaatct gaaaggccag 954361 actgaaattg gcgggaatat gactggagaa tcctgcgatg tgaaagggaa gcttagcgta 954421 ataggtgatt gtgaaacaga aatgttccat gtcacaggct gtgttgatgt atcggggtta 954481 ttaaattcgg gtgagatcaa gctgggattg agccatgata taagccatgt gcaggaaatc 954541 ggcggaacaa caattacagt gaaaagacgc gcgagttttt ttagccggaa gaaagggaag 954601 ctgatcgccg atgtcataga aggagatcgg gtttatttgg agaataccga agcggcagtt 954661 gtcaggggaa aagaagtgat catcgggccg ggatgcagca tcggaacgat tgagtacgaa 954721 tacaaatgtg aatgcgatcc gcattcacag attaaagaaa aaacaaaact gtaaaacatt 954781 gttctgttat acaaaaaggg tgctctttca ggagcaccct tttttattct tttccaggct 954841 tgctttcgta tcctgcggta aaaattgata ctaaaaaagt gacaatgaca cccatcatga 954901 tgattgtttt caccgtctct ccccctcttc aatttttccg tgctgtccga gtctggatga 954961 ttctgtattt ttctttatta tgaacggtcg cagtctgcct tgtcaacgat gtatgagtat 955021 ctttattttt aagaaaccaa agcatgtatc acgagatggc ggcatagatt gtatcaaagt 955081 accttatttg catagtgtat caaacatgat agaggaggtc cttatggata tattaaagaa 955141 aattgaaaag tacagagagg aagagcagcg gctgaaatgg gaaggaactt tcgccgatta 955201 tttggagatt attaaagaaa atccgatggt cgcgcaatct gctcattctc gagtttttaa 955261 tatgataaaa gacagcggga tagaggagat tgacggacgc aagaagtaca gtttttttga 955321 ccgcgagctg ttcgggcttg aagaatctct ggagcgtctt gtggaagagt attttcatcc 955381 ggctgccaaa cgtctagatg tcagaaagcg gattctattg ctgatggggc ctgtgagcgg 955441 cggtaaatcc acgctggtca caatgcttaa aaaaggtctc gaagcgtaca cgctgacaga 955501 taatggcgct gtatatgcga ttaaaggctg cccgatgcac gaggaccctc tacatttaat 955561 cccccatcat ttacgcgatg acttttacag agaatacggc attagaatag aaggaagtct 955621 ttctccttta aatgtcatga ggctggagga agagtacgga ggaagaattg aggatgtgaa 955681 ggtggagcgc atcttctttt cagaagataa gcgtacggga attggaacat tcagtccctc 955741 tgatccgaaa tctcaggata ttgccgattt gacggggagt attgatttct caacaatcgc 955801 cgagtacggt tcagaatcag atccgcgcgc ttatcgattt gacggagagc tgaataaagc 955861 gaaccgcggg atgatggagt ttcaggagat gctgaaatgt gatgagaaat ttctctggca 955921 tttgctttcc ttgacacagg aagggaattt taaagctggg cggtttgcgt taatttctgc 955981 tgatgagctg atcgtggctc acacgaatga aacggagtat cgctcattta tttctaataa 956041 gaagaatgaa gccctgcact caagaatcat cgtgatgccg gttccttata atttaaaagt 956101 gtctgaggaa gagagaattt atgaaaaaat gattgcagaa agcgatgtgg cggatgttca 956161 tattgccccg catacgttga aggtcgccgc gatgttctca atccttaccc ggttaaaaga 956221 gccgaagcgg tcggatattg atctggtcaa gaaaatgaga ctgtatgatg gggaaagtgt 956281 ggaaggatat aactctgtcg acgttgagga tatgaaaaaa gaatataatg atgaaggcat 956341 gagcggaatt gatccgcggt acgtgatcaa ccggatttct tcaacgatta tcagaaaaaa 956401 tatggaatcg attaattctc tcgatgtcct tcgctcctta aaagaaggtc ttgatcagca 956461 cccatcaatt tcaagcgagg acagggagcg gtatttgaat tttatctctg ccgcccgcaa 956521 ggaatatgac gatattgcga aaaaggaagt tcaaaaagcg tttgtttatt catatgaaga 956581 atcagcaaaa acacttatgg acaattacct cgataacgta gaggcctatt gcaataaaaa 956641 caagcttcgt gatcctttga caggagagga aatgaaccct gacgaaaagc tgatgagatc 956701 catcgaagag cagatcggca tttcggaaaa cgccaaaaaa gcgttccgcg aagaaatttt 956761 aatccgcatc tcggcctatg cgagaaaagg caagcggttt gattacaatt cccatgaaag 956821 actgcgtgaa gctattcaga aaaagctgtt tgctgatctg aaggatgtcg ttaaaattac 956881 gacctcaaca aaaacgccgg atgagcagca gctgaaaaag gtaaatgaag tcgtggcccg 956941 tttaattgat gagcacggct acaactcgac gagcgccaat gagctgctga aatatgtcgg 957001 cagcctgctg aaccgataag caacgtgacc cgtccgaata gggcgggtta ttttgtccca 957061 ttttctaaat agtttgtcaa ttaaacgtgc atatgtgcat atgatgaata taaatctttt 957121 caaaagactt gtttcataat ctggcacaag ccggaatacg tatgtatcac gaccacaaat 957181 ggttaaggag gggaattcat gtcccaaaat gacagcggcc attttttgat ttctgaggaa 957241 aactggtccc tccatcgcaa aggcttcgat gaccagcagc gccaccagaa aaaagtgcag 957301 gaagcgatca aaaacaatct tccggacctc gtaactgagg aaagcattat tatgtctaat 957361 ggaaaagatg tagtgaagat cccaatccgt tcacttgatg agtataaaat ccgttataac 957421 tatgataaaa ataaacatgt agggcaagga gacggcgaga gccaggttgg agatgttgtg 957481 gcccgggatg gatcagacaa aaaacaaggg cctggaaaag ggcagggtgc cggtgatcag 957541 gcaggcgagg attattatga agcggaagtt tcattaatgg atttagaaga agcgcttttt 957601 aaagaattag agcttccgaa tctccagcaa aaagagcggg acaatatcat tcatacagat 957661 atcgagttta atgatatccg taaaacaggg ttaaccggta atattgataa gaaaagaacg 957721 atgatgtcag cctttaaacg aaacgcaatg tcaggaaaac cgtcgttcta cccaatttat 957781 ccggaggacc tgaaatataa gacgtggaat gacatcacaa agcccgaatc aaaagccgtc 957841 gttttagcca tgatggatac aagcggcagt atgggggttt gggaaaaata catggccaga 957901 agcttctttt tctggatgac ccgttttttg cggacaaaat acgagactgt ggaaattgaa 957961 tttattgccc atcatacaga agcaagagtg gtctcggagg aggatttttt ctcaaaggga 958021 gaaagcggcg gaacaatttg ttcttccgta tatcggaagt cgcttgagct tattgatgaa 958081 aagtacaatc ccgcccgcta taacatttac ccgtttcatt tttctgacgg tgacaacctg 958141 acatctgata acgcgcgctg tgtgaagctg gtcaatgata ttatgaagaa ggccaatctg 958201 ttttgctacg gcgaggtcaa tcagtacaac aggcattcaa cgttaatgtc tgcatataaa 958261 aatgtaaaag atgagaaatt taagtactat attttaaaac agaaatctga tgtttttcag 958321 gctctaaaga actttttcag aaatgaagag tctggtgtaa gccatcaatt ttcgtaatga 958381 aaagcccatt tcagggcttt tttttattta ataaaagcaa gaaaacgctt gcgaaaaaaa 958441 tacgggagaa aaagaaattt ttcctttgac aaatcttctt tcatttatta atattttatc 958501 ttgtgaacta ttattgagga atgaggtgaa aaggagttga ctgaatcaga acgtgctttg 958561 ctcacttttg aacagctctt cgatacgtct cgggcgatat ataaaaaaca gaagaagata 958621 ttggagattg tgcttgagcc ttttgatatt acagtccttc aatatttgct gatgtttaaa 958681 attcatcaaa gcggaagcac cccgctaagc aagctggcaa tgtcgcttga tcttaagcct 958741 gcttctgtga cgcggatgac agatattctg tataagcgcc aattgatgaa tcgatatgac 958801 agtccggatg accgccgtat cgtcatgatt cagttaaccg aagaggggga agaactgata 958861 gaaaaagccg ctgtgcaata tgcaaaaatg ggtgctggct tgtaccaaaa gcttgatacc 958921 tcccagctgc agtatttgcg caaactagcc ggaagtttaa cgaagcttgc tgaaggctgt 958981 tcagaaaaaa gcggtaatta aaaacttctc acatattttc accagctttc cgcaaaatga 959041 tagaggatga aacgaaagga gaaaacaaaa tgaacagagg acgtttaatt ctgaccaaca 959101 ttatcggttt gattgttgtt cttgcaatta tagctggagg tgcttactac tattatcaaa 959161 gcacaaacta cgtaaaaaca gatgaagcaa aagtagcggg cgatatggct gctattactg 959221 ctccagcagc aggtaaagta tctgactggg atctggacga aggaaaaaca gtgaaaaaag 959281 gcgacacagt tgcaaaaatc aaaggtgaac aaactgttga cgtaaaatcc attatggatg 959341 gcacaattgt gaaaaacgaa gtgaaaaacg gacaaaccgt acaagctggt acaacaattg 959401 cacaaacgat tgacatggac aacctataca tcacagcaaa tattaaagaa acagatattg 959461 cggatattga agtaggaaat agtgtagacg tagtagttga cggagaccct gatactacat 959521 ttgacggtac tgtagaagaa attggttatg cgactaactc aacttttgat atgcttcctt 959581 ctacaaattc aagcggaaac tacacaaaag taacacaaaa agttcctgtg aaaatttcaa 959641 tcaaaaaccc atctgataag gtgcttcctg gaatgaatgc atctgttaaa atttctgagt 959701 aaaacagatc agtcatcaaa ccatgaaagg aggttgtctt agatggctac aggcaaagaa 959761 aaaaatgcaa aaaaccctat gtcattgctg attgtgctaa tggcgggttt atttttggca 959821 attctaaacc aaacactgct taatgttgca atgccgcact taatgactga atttggcgta 959881 agtgcaacga cgattcagtg gctgacaaca ggttacatgc ttgttaacgg tgtattgatt 959941 ccgttatctg ctttcctgat tacacgattt ggccagcgga gtctctttct cgtcgcgatg 960001 ttttgtttta cgctcggtac gttagtctgc ggtatcgcac ctaacttctc tacaatgctg 960061 atcggccgtt tgattcaggc cgtgggcgga ggtatcttgc agccgctcgt tatgacaacc 960121 attctgttaa ttttcccgcc tgaaagcagg gggaaaggaa tggggatttt cgggctagcg 960181 atgatgtttg ctccagcggt cggcccgact ctttccgggt ggattattga gcattataca 960241 tggcgcatta tgttttacgg acttgtgccg atcggcgcaa ttgttatcat tgtggctttc 960301 ttcatcttta aaaatatggt ggagccgcaa aaaatcaaac tcgatactct tggcgcaatc 960361 ctctcgattg tcggattcgc ctccttatta tacggagtca gtgaagccgg atctgacggc 960421 tggaccgacc cgattgtatt gtctacagtt attatcggag ccattgcaat tgttgctttt 960481 gttgttcagc aattgcgtca tgatgatccg atgcttgatt tcagagtgtt taaatatgac 960541 attttctcac tctcgagtgt cattaatatc attattacag tggcacttta cactggtatg 960601 ttccttttac cgatttatct gcaaaacctg gtcggcttta cggcgcttca atccggtctg 960661 cttctgcttc cgggtgcgat cgttatgctg attatgtcac cgatctcagg tattttgttc 960721 gataaattcg gaccgagacc gcttgcgatt atcgggcttc tcgtgacagt ggtaacaacg 960781 tatcaataca cgcaattgac aattgataca ccatatacac acatcatgct gatctattca 960841 attcgtgcat ttggtatgtc tctcttaatg atgccagtca tgacagccgg gatgaaccag 960901 cttcctgccc gtctgaacag ccacggaacg gcgatgagta acacgcttcg ccaaatcagc 960961 ggatcaatcg gaacaagttt aattacgacg atttatacaa accggacgac attccattat 961021 tcacaaattg cagataaaac aagcacggcg gacccgaact tcctccatgc gttccaaaat 961081 gcagtttcga atttaatggt gaatatgaat gtgtcttatg atacggcgaa aacatatgtg 961141 tactcacata tttataaaca cgcatcactc gattccaatg tcatggggat aaatgatgcc 961201 tttatgtggg caaccttatt ctgtgtagca ggtttgattt taagtatctt cctgcgtgac 961261 gtcagaaaag ataaattgcg taagaagaaa aaagaggagc tttcattact tcctgctcca 961321 aaagaagcta aggaatctta atctgtacag ggaggtttcc tgaatgaaaa tttatgtagt 961381 gtatgatagt gaaggcgaac atactaaagt gcttgcagaa gcgattgctg aaggcgcgag 961441 agaaaacgac gcggctgaag tgttcatcga ccatgtagat caggctgata tccgcaagct 961501 taaagatatg gatgcgatta tttggggatg cccagggcat ttcggaacaa tcagctccgg 961561 tcttaaaact tggatcgaca gacttggcta cttgtgggct gaaggcgagc tgatcaacaa 961621 agtcggtgct gtcttctgca caacggcaac aacacacggc ggcttggaaa tgacaatgca 961681 caatttaatc acgccgatgt tccaccaagg catgattgtt gtcggactgc ctggcaacgt 961741 gcctgaaaac gcactttatg gctcttatta cggagcaggt gtcacttgtc cggtagacag 961801 tgatgagtta atgtctgagg aaggtattca gcttggacgc gcgttgggaa gacgtgtcag 961861 ccaagtcaca ggaaacctaa cagcaggaca gtaaggagag gttgaaatgg ccattattat 961921 agcaataatt gctgctgtca ttgtcattgc ggcccttatt acatttaacg tccgcaacgc 961981 ctcacctgga cctgagaagc aagaagcaac cgatagaatc gcacctccag aagaggaaaa 962041 aaacgaagcg cattaccctg ctgaagcaag ggctgccgag catacgccat ccgttgtcaa 962101 aaacgattct ccaaaagaga agcgtgacac aatgggtgat gatatttaca ggcaggcgct 962161 gcaaaagttt aagcattctg atgaagttca tgcagaagaa gaggtcactg aggaaagtga 962221 caaaatgcag gaccgcagct atcgtgatgc gctgctctct atgaaaaata agaaaaagta 962281 atgaaaaagg caaatccgtt tactcatgcg ggtttgcctt ttttgctgtt tccatcaatt 962341 atgtttttat caaataaatc catggaatat gttgtattcc accttgatct agtgtactat 962401 gttactcata caccgaggat tttttccggg aggtaaagac atgaattctt ttttaggttt 962461 attaaagaaa gatatcaagc tttcaagaat gtggctgcta gtatggatat gcggaatcat 962521 tttcttattg ggaacaggcc atattatagc ttctcgcacg aaagaacctc tagtcatttt 962581 tggttttttt gttgcagttg ctttttttct gcttttctta tctcctgttt ttgtttttta 962641 tcaccttcgc aaggaaggga aatcacagct ttggctgtac aatccaaatg gcggcttatg 962701 gctgttttct tctaaattgg cagcatcttt gctctatcaa tttgtgattc agttggcatt 962761 aacagcctat ggcatatgga tgtatcatat gctctctgta aaaaatctgc tggagcatca 962821 agttgatata acgagtacag tggctttgct gaatatgtat gggcttattt cttcgttaga 962881 tatgtcagta acagtcattg tgttttggac tgtttttcac tctctcagaa attggcgcgg 962941 aatgcggtgg gctgcgatgg ttctgttggt cgcaatgtgg ttattcttcg atgaatacat 963001 cataagccct ttggttgaat ctcaaaagca tttctggcct gtaacagtct attgcaattt 963061 tgatttccac ttccacaatg tttggagatt ggaactaaaa cctatccatc tgtctgtgct 963121 agggtttcct attgctatag tcatcacatt cttgctgctc atcatggctt caaaactgct 963181 tgatcgtaaa gtagaggtgt aaatatggac aatcaattcc aatcctcgaa accgatttat 963241 ctgcagatcg ctgatcagat cttttatagg ctggtcagga aggagctgct cccaggagac 963301 aagcttcctt cagtaagaga aatggcgatt caaactaaag taaatcccaa tacaattcaa 963361 agaacttaca gtgagatgga aaggctgggt attgtggaga caagaagagg tcaagggacg 963421 tttattgcgg aaaaagcaga aatcgtagac gagctgaaag acaagctgac acgagaggtg 963481 ctggaaggct ttgtcaagca aatgaaagag ctggggctaa cgaaagaaga aatgttagaa 963541 gggattaaaa cattcacaga gggaggctaa aatggaaatc aagctagaac atgtatcaaa 963601 aaaatacggc cgccatacgg ccgtcaatga tgtgtcaatc accctatcat ccggacggat 963661 ttatggcctg attggaccga acggcagcgg caagtcaacg accctgaaaa tgatggctgg 963721 ccttctgttt ccgacttcag gatttgtaaa agttgatgaa gagcaggtta cgagagaaat 963781 ggtgcgtcaa acggcttatc ttactgagct tgatatgttt tatccgcatt tcactgttaa 963841 agatatggtg aatttttatc agtcgcagtt tcctgatttt catacagaac aggtttataa 963901 gctattgaat gagatgcagc tgaatccgga aaaaaagatc aaaaagctat caaaaggaaa 963961 tcggggcagg ctgaaaatcg ttcttgcttt agcgagacgg gcagacgtca tcttgcttga 964021 tgaacctttt tccgggcttg atccgatggt cagggattcc atcgtaaaca gccttgtgtc 964081 gtacattgat tttgagcagc agattgtcgt gatcgcgaca catgaaattg atgaaattga 964141 gactttgtta gatgaagtaa tcatcctcgc caatggagaa aaagttgcgc agcgtgaagt 964201 agaagatatt cgtgaacagg aaggcatgtc tgttttgcaa tggtttaaat caaaaatgga 964261 agtttgctag aaagaggagg aatatgatga aaacagtgtt ggaattgaaa aacgtgacta 964321 aaaacatcag aggccgaacg atcattgatg atctcagttt tacgattcgt gaaggcgagg 964381 tattcggttt tttaggacca aacggagcgg ggaaaacgac aaccatccgg atgatggtgg 964441 ggttaatgaa gctgtcgaaa ggtgatgtcc tcatttgcgg ccaatcaatt acgaaagaat 964501 atgccaaggc gattaagcat atcggagcga tcgttgagaa tcccgagctg tataaatttt 964561 tgagcggata taaaaatctc cagcaattcg caaggatggt caagggtgtc acgaaggaaa 964621 aaattgatga agttgttgaa ctggtcggtt taacagacag aatccacgac aaggtgaaaa 964681 catattctct ggggatgaga cagcgtcttg gcttggcaca atgccttctg cacgatccga 964741 aagtgctgat tttggatgaa ccgacaaacg gccttgatcc ggcggggatc agagaaatca 964801 gagatcattt aaagaagctg acccgagaaa gaggaatggc tgtcatcgtt tcaagccacc 964861 tgctgtcaga aatggaactg atgtgtgatc gaattgcgat tctgcaaaaa ggaaagctga 964921 tcgatattca aaatgtaaaa gatgaaaaca ttgatgagaa tgatacatat ttcttccagg 964981 ttgagcagcc gagtgaagcc gctactgttt taaatcagta cgatttgctg agtaagacaa 965041 atggtgtaga aatcaaactg gctaaagagg aagtccctgc ggttattgaa ttgctggtga 965101 tgcagcaaat ccgtatttat gaggtcaagg tcataacaaa atcattagag gaccgtttct 965161 tagaaatgac aggtgaaaca aaagaggagg ttcagcatgc ttaatttgat ttataatgag 965221 tggctcaaaa ttttcagccg tgccggaaca tgggtgatga tcggaattct ggggctgaca 965281 atggttggat ttgcattttt ggcgaatcat ttttctgccg gtgaatcaaa ttcccattgg 965341 aaacaagagc ttcaagcaca aaacgccgaa ttaaagaaag aaatcaaaga agatccttca 965401 ctgaaagatg ggtataaaga aacaatcaca ctcaatgact atcgcatcga gcataatatc 965461 cctagtgaca cgggctatac ggtatggtct tatgtaacgg attcagcaaa ctttaccatc 965521 cttaccggtc tgtttactat tatcatcgcg gccggaattg tcgcgaacga atttaattgg 965581 ggaacgatta agctattaat gattcggccg ctcagtcgtt ttcaaatttt gatgtccaaa 965641 tatattacag ttctcctgtt tgggctcctg ttgctgttga ttttatttat cggttctact 965701 ttattagggt tgatcttctt cggaacgggt ggtgaaaccg ccgcgaatat tcatttaatc 965761 tataaggatg gccatgtcat tgagcaaaac atgatggggc atttggctac aacgtatctt 965821 tctgaatccg tctcggcttt aatggtggcg acgatggcgt ttatgctgtc tgcggtattc 965881 agaaacagct ctcttgcggt tggtttttcc atcttcttgt tggttgccgg tacgactgca 965941 actgcattta ttgcagcgaa atttgactgg gcaaagtata tattgtttgc taatgtcgac 966001 ttgactcagt atgtggatgg cacaccgtta ataaaaggga tgactatgac gttttctctc 966061 gtcatgctgg cgatctactt tatcatcttc ctgttgcttg ctttcggaat cttcatgaag 966121 cgggatattg caaactaata aaaaaagctg ttttgcttat gcaaaacagc ttttttgtca 966181 aaataaaaac tgcaggtttg cacctgcagt ttttcatatc aatttatgct tacgcttctt 966241 tagtaacgtt agcagcttgt ggtccgcggt ttccttcaac gatttcaaaa gaaacagctt 966301 ggccttcttc taaagttttg aagccttcgc cttgaatagc agagaaatga acgaatacat 966361 cgtcttgacc ttctacttcg atgaatccga aacctttttc agagttgaac cattttactt 966421 taccttctaa catgaaattt cctcctaaag cgatcataac gcttaaattc actattcttg 966481 ctcttaacaa actttcaaga cgaaaactct tacaaaactt tcttcttaaa gatagttcga 966541 acaaaaataa ttacctttac tctaccagta atcttcagaa aaaacaactg cttattgaaa 966601 tttttttcgg aaaataccat atttattttt caatttgata tttatttacg gaaattcatc 966661 tgttttctcg atatgtgatc atacgtttgc cttagtattc cttcattttg ggaagataag 966721 taataggaat tgacaacctt attggatatg agtaaggtaa aagttaatca atattacaaa 966781 tgacaacgtt tatcaactaa gagagcgtat gatttttatg tctgatattg cttgcatgct 966841 ctaatacata gataggagta tggtcacaat gaaaaagtgg cttatatgca gtttcgtcct 966901 tgttcttctc gtttcattta ctgcatgttc accgtctgca gaacatgaat cgataaaaat 966961 cgggattgct gagtctgacg gggcaatatg gaactatatt gctcaaaagg ctgaagaggc 967021 agggctggat attcagctga tccctttttc tgattatgcg gagtctgata tcgcacttgc 967081 taacaaagaa attgatgcca acgcctttca aaccatttca tattttcagt cgttcactga 967141 aaaatacaaa cttaatttgg caccgctcgg gacgacatac ataacgccca tgggcattta 967201 ttcaaaacga tatgaacgaa tccgagatat atcgcgggga gctgtcgttt ctgttccgga 967261 taaagcgttc gattttggca gggcgcttac ggtgctccag gaagcgggtt tgctaacgct 967321 gaaaaacgga tttaacggaa caggttcagt tgatatgatt aaagataatc cgagacacct 967381 gaaattaaaa gctgtccggc aacaggatgc agtgagcggt gccgacgtgt ttgtcatgaa 967441 accatcagaa gcaaaaaaag cgggcttgaa cccgaaaaag catacgctaa agagcggcgg 967501 actcatgtct gaggaagaga tgaatttgat tgttgtcaga gcggaggatc aagatcggga 967561 agcgctgcaa accattcttg agctttatca agctgatgat acagcggcat ttatagaaaa 967621 agaatatcag ggagatcttg tcccggcttt tctgcctttg aaacgtcttt cagattggaa 967681 gaatgaattc gaacattgaa ttcattcttt tttttctgaa aaacacactc tgttccgtcc 967741 cgtttctttc gctttgtaaa gcatttgatc ggcaagaatg ggcaaggatc ctggctgttc 967801 cgtattattg gggtaatgag cggcccctag tgatatcgta actgaaagct cgtcgccgtt 967861 tgttaataca atcggtgcat cacttacagt gctcctgatc cgttcagcga tccgggctgc 967921 tttatcaaga gaacagttcg gcaggagcac ggcaaattct tcaccgccga tccgagcggc 967981 aggatcagta tttcggatgg tctgcttcag acgtaaccct agctctttga gcacctgatc 968041 tccttcatga tggccatatt ggtcattgat ggtcttaaaa tgatcgatat ccatataaat 968101 cagtgcaaat tgaaaatgcg gggtatcggc cgcctgctga tacagagctt ttgtggtttc 968161 ttcaaatttt cttcggttat acacgcctgt taaaaagtca aagtgcgcct gaaacttata 968221 ttgtttaaaa agaagatgtg catttgtttc atgatcaata atatataaac tgagcatgcc 968281 gcccgctatt gatatgatcc aaaaatacaa atgaagttcg tatgaatgta aatctataag 968341 aaaataaaag gaaaaggaga tcaagctatt tgtgattatt aaaagataga aagcatgttt 968401 tagttgaact ttttttcttc tagaaacaat gagtgacgga atggcagcga tacaaatgat 968461 aataaccgag tatagtgcag atgtgttcat cgtaatcagc aagcggcctg cagtgatcat 968521 ggccagggcc gttgccgttg aaacccagcc tccataaaga gcggcaatca taatagggat 968581 atttcgaaga tcaataattg aatgctgata ggtaaatcca aaaaccatca gaataacccc 968641 gagcaaaccg caggccagtc ctttaacagc ttgaaaggat atgctgtctt ttttatgtac 968701 tagcctttct ttaaacaggt gggtgaagag ataattaaat gtgattaaaa tggtcaaatt 968761 tacaaacagt tctttcagca aatattatca cccttatata aggtactaaa gatggaaggg 968821 aaagaaaaga acaaaaaagg cattatataa ggttttttta cttgaattga taagttaaaa 968881 taattcgcac ttgacccatc ggaattagtg taatatagta aatgagaaaa tttgaaggga 968941 gagtttacct gctttggaga ctttactggt tgtattacat gtatttattt tatttttact 969001 tatcttaggg ctctttgtta tgcagaaaaa acatgtttcc ttctctaaac gtgtatttac 969061 tgcgctgggg ctggggattg tattcggatt tgcgcttcag ctgatttacg gcccgacttc 969121 aaatatagtc attcaaacag ccgactggtt taatattgcc gggggcggat atgtcaaatt 969181 gcttcagatg gttgtcatgc cgctcgtctt tatttcgatt ctcggcgcct ttacaaagct 969241 gaagctgaca aaaaatcttg ggaaaatcag cggtttgatt atcgggattt tagtagcaac 969301 aacagcagtt gctgcagctg tcggtatcgc gtccgcgctt tcatttgatc tgcaggcgat 969361 tcaggttgac caaggaagta cagagctttc acggggacag gagcttcagc agaaatcaga 969421 ggatatgaca gcgaaaacgc tgccgcagca gattgttgaa ctgctgcctg gaaacccgtt 969481 tttagatttt acgggagcta gaccgacttc aacgatcgct gtcgttattt ttgccgcttt 969541 ccttggagtg gcattcctcg gcgtaaaaca caaacagccg gaacaggcag aaacatttaa 969601 aaaactggtt gatgccgttt atgccattgt catgcgtgtt gtcacactca ttttgagact 969661 gacgccttat ggggtgctgg ccatcatgac aaaaacaatt gcaacgagtg atcttgacag 969721 cattctaaaa ctgggcatgt tcgtgattgc atcatatgcc gcgttaatca ctatgtttat 969781 cattcatttg ctgctgctga cgttcagcgg cttgaatccg gtgatttatt tgaaaaaagc 969841 ggtgcctgta cttgtatttg catttacgtc aaggtctagc gcaggtgctt taccgctgaa 969901 tattaaaaca cagagaagca tgggtgtacc ggagggaatc gcaaactttg ccggttcgtt 969961 cggtctttcg atcggccaaa atggatgtgc cggcatttat cctgcgatgc tggcgatgat 970021 gattgctccg actgtcggcc aaaatccatt tgacccggtg tttattatca ctgttatcgc 970081 agtcgttgcc atcagctcct tcggggttgc cggagtcggc ggcggagcga cattcgcggc 970141 gcttcttgtt ttatcatcat taaacatgcc tgtcgcgctc gccggtttgt taatctcaat 970201 tgaaccgtta atcgacatgg ggcgtactgc tttgaatgtc agcggaagca tgacatccgg 970261 tcttattaca agtaaggtca caaaagaaat tgatcaaggg gcatttcatg atcaatccag 970321 agtgattgaa gctgaagaag cgtaacatat gaaaacgtgt aatccaagag gattacacgt 970381 ttttttaacg gccaggctct aagtcctcca gcatttccat catcgtgttg tcgtccatga 970441 cattcattgc gttttgttca aaatgaatgg gttcagcata atgcggctgt ctttttttcg 970501 cggctgtctc agtttgccta gtttgagact gtgtatgctg atgctgtggt tgctgctgtc 970561 cagcgtgctg gtgctgacgg ccattttgcc gctggctttg atgctgcgaa cggtcctggt 970621 tatcaccgct gcttccgctg cttccgctaa atgcttgttt gaccatgttt cctacattag 970681 aagcatcaaa cgtgttattt tctgaatttc gtctgttcat ttgtcctgtg ataaacccgc 970741 tgattctttg gcggatctga ggtgataatg cagtaataag catagttgat cctatgatca 970801 atgctgcggg gctgattcct cttcgctggt tgaacaacat gatccctcct ttgcagtgta 970861 ttcatatttt ccccctcgtt agacaaatta accgttatat ttcccgggaa agcatttcct 970921 ccagatttgc atgcataatt aaagccagtt agaaaaacct ataagtaaag tgataaagga 970981 ggaattcaca tgtttggaaa aaaacaagtc cttgcgtctg tgcttcttat ccctttgctt 971041 atgactggct gcggtgtagc cgaccaaggt gagggcagac gtgataataa tgatgtaaga 971101 aacgtaaatt atcgaaatcc ggccaatgac gatatgcgga atgtaaacaa tcgggataac 971161 gttgacaaca atgttaatga taatgtcaat aacaatcgtg taaatgacga taataacaac 971221 gaccgaaaac ttgaggttgc tgatgaagca gctgataaag taacagacct aaaagaagta 971281 aagcatgccg atatcattgt ggctggaaat caagcctacg ttgcagtcgt tttaaccaat 971341 ggaaataaag gtgcagtaga aaacaatctg aagaaaaaaa tagccaaaaa ggtaagatct 971401 actgacaaaa acattgataa tgtttacgtt tcagctaacc ctgattttgt agagcgtatg 971461 caaggatatg gaaagcgtat tcaaaatggt gacccaatcg ccggattatt tgatgaattt 971521 acacaaactg tacagcgtgt attccctaac gctgaataaa tgaaagaagc cgcacaattt 971581 gtgcggcttt ttctttgcgt taatgacaca ctgcgaactc aggctgcata gagtaaaaat 971641 aaaaaggtac aagacggacc ggctcaggga gggagacgtt tgcgggatgg cataggaaag 971701 cgtgcggcat ccgctctatt cctgtgcgga gtccttgtga tgctggctgt aagctcagcc 971761 atcgtatcaa gcgcgatgta tatcctgtct tttccaggtc aggcatctgg aataacaaaa 971821 gaacaagtga cgaagcacat gaagaaagag tcattcaaac aggccgatat ttattacact 971881 tctaaggaaa agtccttact gccattgacg aaagaaacgc ttgaatatgc ggtcagtatt 971941 aatcagatta tgattggata ttcgaatcaa aagcctattg acattatttt ttttcctaat 972001 gaaaaacaga tggaggctta ctccggttta ttggatgtag ttggttttta ttctgaacgg 972061 gagcagctga tcggattgtt gcctgaagag aaaaagaaac tgttagaagg ggacgaggta 972121 gcggtttatt tgtaccagag attgttgatt catgaatact cgcaccatgc gtttcaccag 972181 aaattgaagg agcttgagac ggatcccgat gagtttccgt tatggtttca tgaagggtta 972241 agcgagtgga ttgcgaacta tgaattgctc atagatccga tcacgttttc tgtcgtgccc 972301 tttgaccgtt tgcagactga tcgagactgg caggaagcta gagccgaata tgacactgat 972361 gtctatttgc aaagctttta tatgatcgat gagctgacgg acaaatacgg gaaagacatt 972421 atttcagaaa tgattaagga aacggcaaaa aaaggggact ttgaaaaagg gtttaaatca 972481 gcaacaaagg aaagtcttga tcaatttgaa aaagatttta agaaaaaatt tgaaaaaaac 972541 agtgcggcat tggatagtat ctatccaatg cctttgttat tagtgaagtc cttgctgacc 972601 cattccgcct tgtgtcggag gcatttgtcc ttgggcaggg gcgaatgaat ttcgcagctg 972661 ttccatatcc tgcgcatcaa gctgaggaac ctggtaatag ccgtgtttgt tttggtatag 972721 gaaaatttca aatgccattt caacatactc ctgaatttgc gcagacagta cgcgtcttac 972781 ggccggattt gtcatttcca gagaagccat cgtcagcata gaagcttgtg ctttaatcgc 972841 gcaaagcatt tgtcggctga tgatgctgtc atcaatatca ttcatggatt gaacaggttt 972901 tttaggctgt gacggctgca tgccgtaaac agtctggttg tcttccttca tcatataagt 972961 tgctgttttt tgtgaaggtt cgcttcctgt tttgaagcat tctgcagtta tattgtattg 973021 agatgtgatg aattgatgtt gacgatcaag gatgtttagt aattcttgat ccttacagaa 973081 ttgtctcagc atcataaact gatcaagcac agtaagtgtt ccggaaagca cctcatgcat 973141 atcaaacatt tcatgtccgc cgtggttttt atgcggtttg ccaggaatac ctttgttcat 973201 ttgggattgc tgctgctgat tgaactgatc caaaccgaat tcctcctttt ttttcagatc 973261 agctgtattt tgtgtcagtc tgccgtgtat tatgcagaag cctgaaagga attatatgct 973321 gtctgtcgaa atgataagca gacaaaatcg ttgtcattat gtgtataagg gaggaaatat 973381 gatgaggcgt attctgcata ttgtgttgat cacggcatta atgttcttaa atgtaatgta 973441 cacgttcgaa gctgtaaagg cagctgaacc gcaacagcct atatcgattg agaaggcaat 973501 acagcaaaaa gaaggacagg cacttgtcga aggatatgca gtcggccagg ctgtttcccc 973561 gcagcattat aaactgacaa gccctttttc aaatgattat aatgttgcgc tggcagaccg 973621 taaaaacaaa acatcgcccg aacacatcct tcctgtgcaa atcccctccg ccttcagaag 973681 ccaatttggg ctgcaaacca atccgcttct tcttgggaaa aagataacgg ttcaaggaaa 973741 gcttgaaaat tactttaaca cgacaggact taaaaacgtt cagtcgatga acgtaaccga 973801 tgacacaaaa actccgccgg ctgaacagca agtgaccata aatgaagcac ggggaaggct 973861 gaatgaagaa gtaacgataa aagggatcat tacagctgat caaaacgcaa tcggaggcgg 973921 gaagctgtcg acctttttgc aagatgaaac cggaggcatt aacatttatt cgccatcccc 973981 tgaacaattt cccgaattaa aagagggtat ggatgtcacg gtgacaggga aaatcacgtc 974041 ttaccagggg ctgaaagaaa tcgttccaaa ctcatcaggc atcaaaatca accagtcaaa 974101 tcaatccctc cccgccccca aacacttaac aatcaatgaa cttattaacg gcagcctagg 974161 tgatcagtat gaaggacgcc ttgtgaaact aaccgctttt gtttcctcaa ttccaagttc 974221 tcctgccggc ggcggttaca atgtaacaat gattgatgac gaccatcatg caatgacgct 974281 ccgggttatg aatgaaacag gggtgataaa cgagcttgat gagggcaaat ggtatgaatt 974341 taccggtgtg ttaagcagat accaaacctt tcagctgctt ccgcgaaaat cggctgacct 974401 gaagctgctt gaagagcagc ccgcacctcc gtctgcagag ggagaatatg aagggattgt 974461 tgaccgggta gttgacggcg ataccattca tcttaaatct ccggtgcttg gaacgacaaa 974521 aatccggttt gtaaatgtag atgcacccga aacatatcac acaccaaaaa atgacgcaga 974581 tgaaaatcaa ttaagatttg gcaaaaaagc atctgactat ctaaaaacgg ttctgtcccc 974641 gggtgataaa attactgtca aggtcgggag tgaagccaag gacagctatg gcagattgct 974701 cggacaagtc ataaccgaat caggttcaaa cgtgaactta gagcttgtaa aaaacggcta 974761 tgctccgacg tattttattt ggccggttga caatgaagag gattatcagc aatttcaggc 974821 cgcagtagcc gctgcaaaaa aagatcaaaa aggaatttgg aatgaaaacg atcccctcat 974881 ggaaatgccg tttgaattca gagccagaga gcaagggaaa ggcctgacaa gatatgtggg 974941 ggactcgtcg aataaaacat atgtgcagcc agctgactgg aagaagatag ctgtggaaaa 975001 cagaattttc ttcgcctcag caagtgaagc ggagagcgcg ggatataaaa aaaggcaaac 975061 ggcacctcaa gaacatgtgc cgcttagaat tctcagcatg aatgatttgc atggcaaaat 975121 cgatcagcaa tatgagcttg atcttgatgg aaatggaact gtagacggca cgtttggacg 975181 catggattat gccgccgcat atttaaaaga aaaaaaggct gaaaagaaaa actcgctgat 975241 tgtgcacgcg ggagatatga tcggcggaag ctctccagtt tcctctcttc ttcaggatga 975301 accgactgta gaactgatgg aggacatcgg atttgatgtc ggaaccgtgg gaaaccacga 975361 atttgatgaa ggcacggatg aacttctgag gatcttaaat ggcggtgatc atccgaaagg 975421 cacaagcgga tatgatggac agaactttcc ccttgtatgt gccaattgta aaatgaaatc 975481 aactggagag ccctttttgc cggcttacga catcattaat gtggagggcg tacccgttgc 975541 ttttatcgga gttgtcacac agtcggcagc tggcatggtt atgcctgaag gaataaaaaa 975601 tatcgagttt acagatgaag caacagcggt gaataaggcg gccgaagagc tcaagaaaaa 975661 aggcgtgaag gccatcgcgg ttctcgcaca tatgtcagct gaacaaaacg gcaacgccat 975721 taccggtgag tctgctgatc ttgcaaacaa aacagattct gaaattgacg tgatttttgc 975781 cgcgcataat catcaggttg ttaacggtga agtgaatgga aaactgattg ttcaagcgtt 975841 tgaatatgga aaagcgatag gtgtcgttga tgtagagatc gataaaacga caaaagacat 975901 tgtcaaaaag tccgcggaaa tcgtatatgt tgatcaaagt aaaatcgaac cggatgtcag 975961 cgcgtcagcc attttaaaga aatacgaaac aattgcggaa ccgattatca gcgaggtagt 976021 cggcgaagcc gctgttgata tggaaggggg gtattcaaat gacggcgata cacctcttgg 976081 aaacctgatt gcggatggta tgagagctgc catgaaaacg gattttgccc ttatgaatgg 976141 cggcggcata cgtgaagcgc tgaagaaggg tccaattacg tggggagatc tttacaatat 976201 tcagccgttt ggaaatgtgt taacgaagct tgagattaaa ggaaaagatt taagagagat 976261 tatcaatgcg caaatctcgc cggtttttgg gcctgactac agcatcagcg ggtttacgta 976321 tacgtgggat aaagaaaccg gaaaagcagt tgatatgaaa atggcagatg gcaccgagat 976381 ccagcccgat gccacatata cattgaccgt caacaacttt atggcgacgg cgacaggagc 976441 caaatatcag ccaatcggac tgctgggaaa aaatccggtg acagggcctg aggatttgga 976501 agcgacagtt gagtacgtga agagttttga tgagccaatt gcgtatacaa aagagggaag 976561 aattaagctt gctgaagcca gtgatattga agaccctgta acagaagacc cgataacgga 976621 agagcctgga gatgatccgg ggacggagga tccgattaaa gaggatccaa ggccaggtga 976681 agatttgcct gatataaaag aaactccggg aacagcaccg gttcatcagc ttccgccttc 976741 agccatttcg agattcaatg aaataccaat caacaacaca aaaaccgctg atactgctaa 976801 tagcatcagc acattgccgt tacaaaccga gactgcggaa agcgggtctg atcatcagct 976861 tccggatacg tcagcgggct actataactt tatggtaatc ggtgcggcgg tgacattgtc 976921 aggaacttat ctatatgtca gaagaaaaag gagcgcctcc agaacgtgaa aaaagttatt 976981 ccactattca tcattgctgc cggcctagtg atcgcaggct atggaggctt taaattgatc 977041 gatacgaata cgaaaacgga acagacatta aaagaagcaa agctggcggc taaaaagccg 977101 caggaagctt cggggacgaa aaatagcaca gatcaagcaa agaacaaagc atcatttaag 977161 cctgagaccg gccaagcgag cggcatttta gaaataccga aaatcaatgc agagcttccg 977221 atcgtggagg gcaccgatgc tgatgattta gaaaaaggtg tcgggcatta caaggacagc 977281 tattatcctg atgaaaacgg acaaattgtg ctgtcagggc atcgggatac cgtgtttcgc 977341 cggacgggag agctggaaaa gggggatcag ctccgtcttc tcctgtcata tggagaattc 977401 acatatgaaa ttgtaaaaac aaaaattgtc gataaggatg acacatctat tatcacgctc 977461 cagcatgaaa aggaagagct gattctgacg acctgctatc cgttttcata cgtcggaaat 977521 gccccgaagc gctatattat atatggaaaa cgagtgactt aaaaagccga ggcagtgcct 977581 gcggcttttc ttcatgaaaa atatgtgcgg caaaggtttt tcatatcagc agggaaaggg 977641 gcttcagcaa ctatgagctc gtctgttatc gggtgaaccg cttgtacttt attggcgtgc 977701 agtgcctgcc tgtttagcag cttgctcccg cctccgtaaa gcgagtctcc tgtcaacgga 977761 tggccgaggc tcgccagatg aacacggatt tggtgtgttc tgcctgtttc cagctctaat 977821 tcaacgagcg acagccgttc tttcgcattg ctggccatta ccttgaaatg agtgacggct 977881 gtttgcccgc ctggtgaaac ccggcgtctt gtcgggtgtg agcggtctct gccgatcggt 977941 gaattaattg tccctttttt cgtccgtagc ttaccttcag cgatagcggt atacgtacgc 978001 ttcagcgtct ttttctctaa ctgctggtct aagatggcgt gtgccaaacg atgcttggca 978061 aaaacgatag cgccagatgt atcctgatca agacgatgga cgtggcgcac cttacatgtt 978121 tcgccattta tctgataatg atacgcgatc aaattagcca gtgtgccggt ttgcccatcc 978181 tcattcggat gcgtcgcgat gccagcgggt ttattgatga tgagcatatg attgtcctca 978241 aataaaatat caagctcgcc atactccgga atgaccgaag atgcttcact ttcctgaaga 978301 tcaatgaaca cgcggtctcc cttttttaca atcatattgt ttaagacgga ttcgtgattg 978361 acctttatct gttgatggga catccagtct tgtatcactg gtttagaagc tttgagcgct 978421 gttttgagta cggaaaacag ccattggccg tcctgttttt cattgatgag gatctcaagc 978481 cctctgcctt tttggttcat gttaaatggc tccttttcga agcggaaggc tgctgtttct 978541 cataggaaac acttacctta gctttcgcgt ttttttctgt gctattcttg agtaagactt 978601 aggatattcg atggcaagaa aggtgattga cgtgagaatt gtgaacgcag caactgcaga 978661 acaggagagc tttatcaagg agctgtctat ggagctgatc catgatgtat ttcctcttta 978721 tttctccgaa ctggacattc agcgctttaa aaagaaaggc gttctgtctt taaataacca 978781 ttattaccaa ggaacattaa aagaagcatt tcaaattatg gcttgtctgc aaatgataca 978841 tattatcctg accaagcctt cgccgcactc tgatttgagt gatcaggcga tttttgaaaa 978901 aaacagcaag atgctgaatg attttgggat ttattttccg tttgcttttt ctgactttca 978961 aaagaagact aacaaagcct ttttcggtca aagaaggctg atataatcat gcggcaaggg 979021 cttttctatt tttagaaaag ctctttttgt atcagagaaa tcatatcata aaacctttcc 979081 tctaactccc tttttaaacg gctcgtgtct gaacatacta atgattgaaa ggggtgctga 979141 caatgagttc agttaaagat acaatgacaa cgcaggtggc aaccgtttct ccgaatcaaa 979201 cgattcagga agcggcttct ctaatgaaac agcataacgt cggggcgatc cccgttgtag 979261 agcaaggtgt tttaaaagga atgctgactg accgtgacat tgcattaaga actacagctc 979321 agggccgtga tggccagaca cccgtttcag aagtgatgtc aacagaactc gtatcaggaa 979381 accctaatat gagtctggaa gacgcgtcgc agctgatggc ccagcaccaa atccgccgcc 979441 ttcctattgt agatcaaaac aatctagtcg ggatcgttgc gcttggagac ctggcagtca 979501 atcagatgtc gaacgagtct gcgggatcag cgctgacaaa catttctcac caaaacattc 979561 attaataaga aagagcttgc agtgtgcagg ctctttcttc acataaaacc ttactttttg 979621 aaagcagact tgtttcgggg tatagtgagt gtatacatat gtctcaattc gtactaaagg 979681 agttgtaccc agtgattaaa gcgttaattt ttgattttga cgggcttatt ctagatacag 979741 aaacacacga atatgaggtt cttcaggaaa tatttgaaga gcacggctca gtgctgccgc 979801 tatctgtctg gggaaaggtc atcggaactg ctgcgggttt ccggcctttt gaatatttag 979861 aagagcagat cgggaaaaag ctgaaccatg aagagctcac acaattgaga agagagcggt 979921 ttgccaaacg catggaatca gaaaaagcga gacctggtgt cgaagcgtat ttgaatgcgg 979981 caaaggattt aggcttaaaa ataggccttg cctccagctc tgattataaa tgggtgtccg 980041 gccatttgaa gcaaatcggc ctgtttgatg attttgaagt tattcaaacg gcggatgatg 980101 tggaagaggt gaagccgaat cctgaactct atttattggc ggcaaagaac ctgggggtat 980161 cgccagcgga atgtctcgcg tttgaggatt ctgtcaatgg ttcgattgct gcgaaacgtg 980221 caggcatgaa gtgtgtcatt gtcccgaata aagtaacggg taccttgatg tttgaagact 980281 atgatcacag gcttgaatca atggcggaga tggagctcgc cctattgctt gatcatctga 980341 actcacaaaa ctagaaagga gcgagtaggt tgtctgagaa attagatttg acccggtttg 980401 aaaagaaaat ggttatccgc aatatcgaag agaaagacat cgacaagatt atcgatcttc 980461 aaaaggactg ctttccagga atggagcctt ggaagcggga gcatttaatc agccatttgg 980521 agcattttcc ggaaggacag ttttgtgcag aattcgaagg tgaaattatc ggttcgtgct 980581 caagtctcct gattaacttt gatgaatatg atgaccgcca tacgtggcag gacattacag 980641 atgacggtta tatcaccaac cataatcctg acggcttgaa tatgtacgga attgaagtca 980701 tggtgcaccc gaaatacaga cgaatgaaga tcggccaccg tttgtacgag gcgagaaagg 980761 acttagccag acgcttaaac ctgaaaagca tcatcatagg cggacggatt ccaaactatc 980821 acaaatatgc agaggaaatg acagcgagag agtatgttga acaggtgaca cgccaccaaa 980881 tttacgatcc ggttctttct tttcagctga tgaacggctt tacccttatg cgaattaacc 980941 cgaactatct cccggatgat acagcttcga tcaagtatgc gacgctgatg gaatggaata 981001 atgtcgatta tctaccgcag cagacaaaac gctattataa atcggcgttc cctgttagaa 981061 tttgtgtgat ccaatacgaa atgaagaaaa tttattcctt tgaggaattt gcgaatcaag 981121 tagaatacta tgtcgatgtt gcttccgacg caagatctga ttttgcggtg ttcccggaaa 981181 ttttcacaac ccagctgatg tccttccttg aggaacggtc accgagcttg gcggtgcaga 981241 gaattaccga gtatacagaa gattacatca gcctgtttac tgacttggct gtgaagtata 981301 acgtcaacat tatcggcgga tctcatttcg tcgaagagga aggcaagatc tataatatcg 981361 cttacctgtt cagacgggac ggaacgatcg agaagcaata caaactccat attacgccga 981421 atgaacgcaa atggtggggg atcagcgcag gagaccaagt tcgcgtgttt gatacggact 981481 gcgggaaaat cgcgatccag atctgttatg acattgaatt tcctgagctt gcccggattg 981541 cggctgataa aggagccaaa atcatcttta cgccattttg tacagaagac cgtcaaggct 981601 atctgcgtgt cagatactgt tcgcaggcta gagcggttga aaatcaaatt tatacggtta 981661 tctctggaac ggtcggaaac cttccgcaaa cggaaaacat ggatatccaa tacgcccagt 981721 caggcatctt tgccccgtct gattttgaat tcgcccgaga cggcattgtc ggcgaaacaa 981781 acccgaatat tgaaatggtc gtcatcggcg atgttgacct ggaaattctc agaagacagc 981841 gccaaaacgg tacagtgcgc cagctaaaag acagacgacg tgatatttat catattcaat 981901 ataaaaaata attcccaaaa aacccgcctg aattggcggg tttttttaaa caaaagcgga 981961 attgtttagg tgctttcttt aaaataaaag taaattgtat agtggatgtg ccttatggag 982021 tttctgtatt ttcgccattt cctatatcat acagaaaacg gctaggcttc acattgctat 982081 tgcaatggct gtccaagttg tttcgagtgc gacctttatc agtacgatgc tgagcattgt 982141 cactttgcct gttttgcttt ggaagctgca tcctctttct tcttgagaaa ggggatgttt 982201 tattatttac gcggtttatt gactctgacc cggtctggct ttatattgaa ggcagggaaa 982261 tcatcaccaa gacatcacat aaagagaagg tctgtttcaa ttgaattggc attataggga 982321 acgctaatga aatggagatg atggggatgg aaaacattca gcaaaatcag ggattaaagc 982381 aaaaagatga gcaatttgtg tggcatgcca tgaagggagc gcatcaagcg gacagcctga 982441 tagcccagaa ggccgaaggg gcctgggtaa ccgacacaga cggacgccgc tatttggatg 982501 cgatgtccgg tttgtggtgc gtcaacattg gttacggcag aaaggagctt gcggaggctg 982561 cctatgagca actaaaggag ctgccttact acccgttaac gcaaagtcac gcacccgcaa 982621 ttcaactggc ggaaaagctg aatgaatggc ttggcggcga ttatgttatt tttttttcca 982681 acagcggatc ggaagcaaac gaaactgctt ttaaaattgc ccgccagtac catctgcaaa 982741 acggcgacca cagccgttat aaattcatct caagatatcg ggcataccac ggcaatacat 982801 tgggagcgct ctcagctacc ggacaggcgc agcggaaata taaatacgag cctttgagcc 982861 aagggttcct gcatgcagct ccgccagata tataccggaa tcctgatgat gcagacacgc 982921 ttgaaagcgc aaatgaaatc gaccgcatca tgacatggga attaagcgaa acgattgccg 982981 gggtcattat ggagcccatc attacaggcg gaggcatcct aatgccgccg gacggatata 983041 tgaagaaggt ggaggacatt tgccggcgcc acggagccct tttgatttgc gatgaagtga 983101 tctgcgggtt tggacggaca ggtgagccgt tcgggtttat gcactacggt gtgaagcctg 983161 atatcattac gatggcaaag ggaatcacaa gcgcgtatct gccattgtca gcgactgctg 983221 tgaaacggga cattttcgaa gcgtatcagg gggaagctcc ttatgaccgt ttccgccacg 983281 tgaacacgtt cggcggaagc ccggctgcct gtgctttggc gttgaaaaac ctgcaaatta 983341 tggaggacga acagctgatt cagcgatccc gtgatcttgg agcaaagctt ttaggtgagc 983401 ttcaagctct gagagaacac ccggcagtcg gggatgttag aggaaaaggg ctgctgatcg 983461 gaatcgaact cgtcaaagac aaattgacta aagagccggc tgatgccgcc aaagtaaacc 983521 aagtggttgc ggcgtgcaaa gaaaaagggc tgatcatcgg caaaaacggc gatacagtcg 983581 ccggctacaa caatgtcatc cagcttgcgc cgccattttg cctgacagaa gaggaccttt 983641 cctttatcgt gaaaacggtg aaagaaagct ttcaaacgat ataatataaa agtgaattat 983701 taaaggagca catgatgagt tttcacaacc agccgatctt accggctatt cgcaatatga 983761 agcaatttga tgagtttttg aacagttcat tctcttacgg tgttattctt gatattcatc 983821 tcggccagct gaagggcgtg atcaaagaag cgcaaaagca cggaaagaac atgatggtgc 983881 acgtcgatct cattcaaggg attaagcatg acgaatacgg tgcggaattt atatgtcagg 983941 atatcaagcc cgctgggatt atttccacaa gatcgaatgt gattgccaaa gcgaagcaga 984001 agaaaattta tgccattcag cgcctgtttt tgcttgatac aagcgcgatg gagaaaagca 984061 tggagtttat cggcaagcat aagcctgact tcatcgaagt gcttcccggc atcgttccgt 984121 cactcattca ggaaataaaa gagaaaacag ggattcccat ctttgccggg ggtttcatcc 984181 gtacggaaga ggatgtagag caggcattga aagcgggggc tgtagctgtc acaacatcta 984241 ataccaaatt gtggaaaaaa tatgaaaact ttttgacgga aagtgattga caccgctttc 984301 atgcactgat acaattgcac taggttaata cattgtgatg gagaactcgg agaccacagc 984361 agctctttac ggcaaatgtt tatgcacccg taaagcggtt tgttgtggtt tttttattct 984421 cttcttctct atcatgcttt ttaatcgtga ctttaggagg aatgtgctat gacagcattt 984481 tggggagaag tcatcggtac gatgctgctt atcatttttg gtgcaggtgt ttgtgcaggt 984541 gtcaatttaa agaaatcgct ttcattccag tctggctgga ttgttgttgt atttggatgg 984601 ggattgggtg ttgccatggc ggcatacgcg gttggcggca tcagcggtgc ccatttgaat 984661 ccggcgctaa cgatagcgct tgcatttgta ggagattttc cttggaaaga ggttccggtt 984721 tatattgcgg cgcaaatgat cggagcgatc atcggtgcgg tgattattta tctgcattac 984781 ctcccgcact ggaagtcaac ggatgatccc gctgccaagc tgggtgtttt ctcaacaggg 984841 cccagcattc cgcatacatt tgcaaacgtt ttaagcgaag tgattgggac atttgtcctt 984901 gtacttggaa tcttggccat aggtgcaaat caatttacag aaggacttaa tcctttaatc 984961 gtcggtttcc tcattgtagc aatcggtatt tctctgggag gcaccaccgg ctatgctatc 985021 aatcctgcac gtgacttagg tccgcggatc gcccacgctt ttcttccgat tccggggaag 985081 ggctcatcaa actggaaata cgcatgggtt ccggtagtcg gcccgatttt aggcggatca 985141 ttcggcggtg tattttacaa cgctgcattt aaagggcaca tcacaagcag cttctggatt 985201 gtaagcgtta tattggttgt ggtattgtta ggactctatg tttatacgaa atcacattct 985261 gctaaaacat tatcaaattc taaatatatt taatcaaagg ggagacatct tatggaaacg 985321 tacattttat ccttagatca ggggacgaca agttcaagag cgattctgtt taataaagaa 985381 ggcaaaattg tccactctgc tcaaaaggaa tttacacaat acttcccgca tcctggctgg 985441 gttgagcata atgccaatga aatttggggc tctgtcctcg cggttatcgc ctcagtcatc 985501 tctgaatcag gaatcagcgc ttctcaaatt gccggcatcg gcatcacgaa ccagcgcgag 985561 acgacggttg tgtgggataa agatacagga agtcctgtct ataatgcaat cgtttggcag 985621 tccagacaga cgtccggcat ttgtgaggaa cttcgtgaaa aaggatataa tgataaattc 985681 agagaaaaaa cagggctttt aatcgatcct tacttctccg gcacgaaggt gaagtggatt 985741 ttagacaatg tggaaggcgc aagagaaaaa gcggaaaaag gcgagctgct gtttggaacg 985801 attgatacgt ggctcatttg gaaaatgtca ggcggaaaag cgcatgtgac cgattactcc 985861 aatgcctcaa gaacactgat gtttaatatt tacgatttaa aatgggacga tgaactgctc 985921 gacattctag gcgtaccgaa atccatgctc cctgaagtga agccgtcctc tcatgtgtat 985981 gcggagactg ttgattatca cttcttcgga aaaaatatcc cgattgctgg agcggcaggc 986041 gaccagcagt ccgcattgtt cggccaggca tgctttgaag aaggcatggg gaaaaacact 986101 tacggcacag gatgtttcat gctgatgaat accggggaaa aagcaattaa gtccgaacat 986161 gggcttttga caacaatcgc ttggggcatt gacggaaaag tgaactatgc gttagaaggg 986221 agcatttttg tcgcaggctc tgccatccag tggcttagag acggtttgag aatgttccag 986281 gattcatcgc taagcgaatc ttatgcagaa aaagtggatt caactgacgg cgtgtatgtt 986341 gttccagcat ttgtcggact gggaacgcct tactgggaca gcgatgtgcg cggttcggtt 986401 ttcggcctga caagagggac aacaaaagag cactttatcc gtgcgacact ggagtcattg 986461 gcttatcaga ccaaagatgt gcttgacgca atggaagcag attcaaacat ttcattaaag 986521 acgctccgtg tagacggagg agctgtaaaa aacaatttcc taatgcagtt ccaaggagac 986581 ctgttgaatg ttcctgtgga gcgcccggaa attaatgaaa cgactgcact tggcgcggct 986641 tatttggcgg gtatcgctgt gggattctgg aaggaccgtt ctgaaatcgc gaaccagtgg 986701 aatctggata aacggtttga gcctgaattg gaagaagaaa aacgaaatga gctgtataaa 986761 ggctggcaaa aagccgtgaa agcagctatg gcttttaaat aaagtaatac tatggtataa 986821 tggttacaag ttaataagaa cggtcctgag atgaggagag accacagcac caaagtgtaa 986881 gcatgcactt tggctgttgt ggtctctttt tctatttacc gtgacaacaa ggaggaaacg 986941 taatgatgaa tcatcaattt tcaagtcttg aaagagatcg catgctgaca gacatgacga 987001 aaaaaacata tgacctattt attatcggag gaggaattac aggagccgga acagctcttg 987061 acgcggcatc aaggggaatg aaggtcgcac taagcgaaat gcaggacttt gcggcgggaa 987121 catcaagccg atcaacgaag ctggtacatg gcggcttgcg ctatttaaaa caatttgaag 987181 tgaaaatggt cgctgaggta ggaaaagagc gggcgattgt gtatgaaaac ggcccgcatg 987241 tcactacacc ggaatggatg ctgcttccgt ttcataaagg cggcacattc ggttcattta 987301 caacatctat tgggttaagg gtttatgact tccttgcagg tgtgaaaaag tcagaacgaa 987361 gaagcatgct ttcagcaaaa gaaacgctgc aaaaagagcc tttggtgaaa aaagacggct 987421 taaaaggcgg cgggtactat gtggaatacc gcactgacga tgcgagactg accatcgaag 987481 tcatgaagga agcggttaaa ttcggggcag agcctgtgaa ttactccaaa gtgaaggagc 987541 ttctttacga aaaaggcaaa gccgtcggcg tattaattga agatgtgctg acaaagaaag 987601 aatataaagt gtatgcgaaa aaaattgtca atgctacagg cccttgggtc gatcagctca 987661 gagaaaaaga ccattcgaaa aacggaaagc atttgcagca tacaaaaggc attcaccttg 987721 tatttgacca gtctgtcttt ccgctgaaac aggctgtata tttcgataca cctgatggcc 987781 ggatggtatt tgcgattcct cgtgaaggca aaacatacgt gggaacaaca gacactgttt 987841 acaaagaggc gctggagcat ccgcggatga caacggagga tcgtgattat gtcatcaaat 987901 caatcaatta catgttcccg gaactgaata tcactgcgaa tgacatcgaa tccagctggg 987961 cggggctgcg tccgctgatt catgaagaag gcaaagatcc ttctgaaatt tcacggaaag 988021 acgagatttg gacatctgac tcaggcctga tcaccattgc cggcggaaaa ctgactggat 988081 acagaaaaat ggcggagcac atcgttgatc ttgtccgtga tcgcttaaaa gaagagggcg 988141 aaaaggattt tggaccatgt aaaacgaaaa acatgccaat ctctggcggg cacgtcggcg 988201 gttcgaaaaa tcttatgtcc ttcgttaccg cgaaaacaaa agaaggaatt gcagccggtt 988261 tatcagaaaa agacgcaaaa cagcttgcga tcagatacgg ctctaacgta gatcgcgtct 988321 ttgaccgggt agaagcgctg aaagatgagg ccgcgaaacg caacattccg gttcatattc 988381 ttgctgaggc agaatacagt atagaagaag agatgactgc aacccctgct gacttctttg 988441 tccgcagaac gggacgttta ttttttgata tcaattgggt aagaacatat aaagatgccg 988501 ttattgattt tatgagcgag cgattccaat gggatgagca ggcgaaaaac aaacatacag 988561 aaaacctcaa caagctttta cacgatgcgg tcgtaccgct tgagcaataa atcataacgg 988621 gctgtctgca gcccgttatt tctttttacg tgccgaaagg gggagatctc aggttatcaa 988681 gtgacagagg cacccgcttc atataaaata atggcataag ctgatacata ggaggacgaa 988741 tatgacttgg agaaagagct atgaacgctg gaaacagaca gaacatttag atctggaatt 988801 aaaagagcgc cttattgaat tagagggaga tgaacaggcc cttgaggact gtttctataa 988861 agaccttgaa ttcggtaccg gcggaatgcg cggggaaatc ggcgccggga caaatcggat 988921 gaatatttac actgtgcgca aagcatcggc cgggtttgcg gcatacatct cgaagcaagg 988981 tgaggaagcg aaaaaacggg gcgttgtcat tgcttatgat tcccgccata agtctccgga 989041 gttcgcgatg gaagcggcaa aaacacttgc gacacaaggc atccaaacat acgtgtttga 989101 tgagcttcgc ccgacgccag agctgtcatt cgctgttaga cagctgaacg cttatggtgg 989161 aattgtggta acggcaagcc ataacccgcc tgaatataac ggctacaaag tatacgggga 989221 tgatggcggc cagctgcctc caaaggaagc ggacatcgtc attgagcagg taaacgcgat 989281 tgaaaatgag ctgacgatca cagtggacga agaaaataag ttaaaagaaa aaggcttaat 989341 caaaatcatc ggtgaagata ttgataaagt ttatacagaa aaactgacgt ccatttctgt 989401 acatcctgaa ttatcggaag aagtagatgt aaaggttgtt ttcacaccgc tgcatggaac 989461 tgcaaataaa ccggtcagac gcggtcttga agcactcggc tacaaaaatg taacggttgt 989521 caaagaacag gaactgccgg attcaaactt ctccactgtt acatcgccga acccggaaga 989581 gcatgcggca ttcgaatatg ccattaagct tggggaggag cagaatgcag atattctcat 989641 cgcgacagat cctgatgctg accgcctcgg catcgcggtg aaaaacgatc aaggcaaata 989701 tacagtgctg acaggaaacc aaaccggagc gttgctgctt cattacctgc tttctgaaaa 989761 gaaaaaacaa ggcatcctgc ctgataacgg tgttgttctc aaaacgatcg tcacaagcga 989821 aatcggccgt gctgtagctt cttcattcgg ccttgatacg attgatacgc tgacaggctt 989881 taagtttatc ggtgaaaaga ttaaggaata cgaagcatca ggccagtata ccttccaatt 989941 cggttatgaa gagagctacg gttatttaat cggggatttt gcccgcgata aggacgccat 990001 tcaggctgcg cttttggcag ttgaagtttg cgcgttctat aaaaaacagg gaatgtcatt 990061 gtatgaggcg ctcatcaatc tctttaacga atatggtttt tatcgtgaag ggctgaaatc 990121 cctgacgctg aaaggcaaac aaggagcaga gcaaattgaa gcgattcttg cttccttcag 990181 acaaaatccg ccgcagaaaa tggcgggcaa acaggttgtc acagcagaag attacgctgt 990241 aagcaaacgg acgcttctga ctgaaagcaa agaagaagcc atcgacttgc caaaatcaaa 990301 tgtattgaaa tacttcctgg aagacgggtc ttggttctgt ctccgtcctt ctggaactga 990361 gccgaaggtt aaattttatt tcgccgtaaa agggtcatct ttggaagaca gtgaaaagcg 990421 acttgccgtc ctttctgaag atgtaatgaa gacggtggat gaaattgttg agtcaacagc 990481 aaaataattc aagtatgagc tgggtcattg taaatgatcc ggctttttct ttttctcatc 990541 caaaagtctg aaagaaaatc atcctacaag tgaagcaatg aaatacaaaa aactggtata 990601 atcttaaata caagatcaat gccggagtga gaaacgtgag caaaacgagg atggaaaaat 990661 taaaaacgct gaaaacgatt gcggaaacct taaatcaagg gcacgatatc aaagcaacac 990721 tggatgaggt tttaaaagag ttgctgagtc tgacaaacct tcaatccgga tggatttttc 990781 tgatcgaaga agatgggtct tatacgttag cggccgacgc ttatctgccc ccggctttaa 990841 gccgcaagga aaaagtgctg atgtgcgaag gggagtgtta ctgcctgacg aaattcaata 990901 acggagggct tagaaaagct gcaaatatca tgaactgcaa acgcatcgaa tcagcagaaa 990961 acctgcattg ttttgacaca gaagggatta cgcatcatgc aactgtgcct ttagaagacg 991021 gggacagaag attcggattg ttaaatgtag cggcggccgg aaaaaccatg tttgatgagg 991081 aagagctgca tttactcgag tctgtcgcct ttcagatcgg aacggcaatc cagcgtatga 991141 ggctttctga atatcaacaa aaaaatgctc ttttaatgga gcgtaaccgc ctcgctcagg 991201 agcttcacga ttcagtcaat caaatgctgt tttccgtcag tttaactgcc aaagctgcga 991261 agacactaac aaaagatgaa aatttacagc agatgattga tttcatccaa aacctatcac 991321 aggacgcgct cgcagaaatg aaagcgttaa tttggcagct tcgccccgga ggattggaaa 991381 aagggctggc tgaagccatt aaaagctatg gtgcgctcat tggattgaag atcattttta 991441 cacaaaaagg ctgtcctgtt ctgactgatg agcaggagca tatgctatgg cgtgtcgtac 991501 aggaagcttt aaataactgc aaaaagcatg ccggaacgga tacggcgtat gttagtctga 991561 ctgcttcttt gtgccatgcg gagctggata tcatcgatca tggggcagga tttcgctatg 991621 aagcgcatgc cggtctgcct tcacttggca taaaaggtat gaaagagcga gcggaaaaag 991681 ccggagctaa gttttggatt gagtcagcgc ttggaactgg aacaaagctg tccatcaggc 991741 ttccgctaaa aagccgaaaa ggaggggcgg tatgaaaatt gtcattgctg atgatcatca 991801 tgttgtcaga aagggtctgc gttttttctt tgccacccag gatgatattg aagtcgtcgg 991861 agaagctgca actggattag aagccctccg tgtcatcgaa gagacaaagc cggatcttgt 991921 gctaatggat ttgtctatgc ccgagatgga cggcattcaa gccattaaaa aagcaataca 991981 gcaatttccg gatacgaata tcattgtgct gacgagctac tctgatcagg agcacgtcat 992041 ccccgcgctt caggcaggcg cgaaggcgta tcaattaaag gatacggagc ccgaggaatt 992101 ggtgaaaaca cgacaagtgc atggtggcga atacaagctt tctacagcta ttatgcccca 992161 tgtgctgaca catatgaaaa atcagcacga cccggaaaaa gaaaaatact atcaattaac 992221 tagaagggaa aaagacgttc tgactgaaat agcgaacggg aaaagcaata aagaaatcgc 992281 agcagccttg tttatttcag aaaaaacagt aaaaacccat gtatcgaatc ttttagcaaa 992341 acttgaagtg gccgatcgca cgcaagcagc gcttttcgca gtgaaatata acctgaatgg 992401 agagatctca aaatgaacat gttagtcata aatggcacgc caagaaaaca tggcagaaca 992461 agaattgcag catcctatat tgcagctctg tatcacacgg atttgattga tctaagcgag 992521 tttgtattgc ccgtttttaa cggtgaagcg gaacaatctg aactgttgaa agtacaggag 992581 cttaagcaac gcgttacgaa agcggatgcg attgtattat tatcgcctga atatcacagc 992641 ggcatgagcg gcgctttaaa aaatgccttg gattttctaa gcagcgaaca attcaaatat 992701 aagcccgttg cattattggc agtagcggga ggcggaaaag gcggcatcaa tgcgctgaac 992761 aatatgagaa ctgtgatgcg gggtgtctac gccaatgtca ttccgaagca gctggtgctt 992821 gatccggtgc atattgatgt tgaaaatgct acagtggctg aaaacattaa ggaaagcata 992881 aaagagcttg tcgaagaact cagcatgttc gcaaaagcag gaaatcccgg cgtctaaacg 992941 ccgggatttg tttatgtgag aagggctatt tgatcttcat aagtcagctc tgtggcatga 993001 tcaatatatc ggagaaggga atacagcatc ttttctaaaa cggcgtaatc ctgttcaaaa 993061 tgatacgcat gcagaaaatg ctcaattcgt tttgataaca aatcgtcctc tgtacgcacc 993121 attaaaatta ataaattatc ccattgagaa cgatgggtgt aataaagcgc tttatcgtaa 993181 tcggcataat ccatgaatcg cttctccttt cttgggtgag aagttcatga ttagtttatg 993241 ccgcatcctc tgttattgac ggggcaaaac ttgccgtctg cgtcagtaaa ggggtagcaa 993301 tatgagggag acataaaatc aaaatgcctg aatgaagata tcgcttttgg taaacctatg 993361 agggaatata ttctgggtac aggagactga aaaaatgaaa tccctgccgt ataccatcgc 993421 acttcttttt tgcggattga ttatcgtgtc aatggctgca aaaggtcatt caacggacac 993481 agacgagtcc gttcaaaagt gggaacagct tgcctggagc aaaattcagg atgaatataa 993541 gggcgcttca ttttctgatt atgcttatat ggggcgtaca gaggtgaatg atcagcagac 993601 taaagatgtc tttcgggtga cagtcagaca gaaagatgac actttttctg ttcgggccga 993661 agtctatttt catccggtga caaatcatat gatcagcatc aacgtcttta ggctctaata 993721 aaaaactgta cagccgttaa ggccgcacag tttctgtttt tagaaatatc gttttgcacc 993781 gagatagcgc tgtttccagt aagagttgtt catattggaa atgacaactc cggaatcgtt 993841 ggcatttatg aattccccgt tgcctaggta aattccgacg tgggaagggc cggctttata 993901 tgttgaaaag aaaacgaaat ctccgacagc aggctggcta actgatttca ttgtgttcca 993961 atatcccgct gccgttaatc tagatacgga tgtgactttg ttcagtacat agtaaatgaa 994021 tccgctgcag tcaaacccgg acggtgtcgt gcctccccag cgatacggaa ccccaagctg 994081 cgctttagcg gccgaaatca ttgtgttaat cttcgcactc gttgagctgg tggtgtttga 994141 agaaccggat gaagacgatg atgaagcttt tccggaaatg accagctttt ggccaacctg 994201 caagacatcc gtttttaaat tgtttttctc acgaatctgc tgagctgtta cattaaattt 994261 ttgagcaatc acccataagg aatcaccgct tttcaccgtg tatgtagtcg tcgtgccgga 994321 gcttgcattt gacgaagaag acgacgatga tgaagagcct gaagatgctt tacctgtcag 994381 cttcaatact tgtccaacgt aaagcacatc tgatttcaga ttgttgatat ttcggatttg 994441 ctgtacagtc aggttatagt tgtttgcgat tttccaaagt gaatcaccgc ttttaacggt 994501 atatttagtt gttgctgaag tttggttcga tttggatgaa ttgtctttag aagacgtatc 994561 agagccgctt gattttgttt tcaacacctg attcacgtaa atggtgtctg attttaagtt 994621 gttcaagacc ttcaattcag cgatggacat attgactttg tttgcaattt tccaaagtga 994681 atctccaagc tgcaccttat atgttcccgt agaagatgaa gaacttgaac tcttattaga 994741 actgcttttt gaactggagc ttgaactctt attagagttg ctttttttac tggaactaga 994801 gcttgaagaa acagtaccgg acacctttaa tttctgccca gcacgaatta aatcgctgct 994861 tagtccgttt aattttttca gttcctgcac cgtcatttta aactcatttg cgatcagcca 994921 aagtgaatct ccgcttttca ctgtgtaaac agaacttccg ctcttcttgg ttgttgagct 994981 tgaagtagat gaagaagtgc tggatttgct gcctggaata gtaagcgtct ggccgatcga 995041 cagaacagta gtcgaaagat gattggcgga tgtgagggcc gccacacttg tgttataggt 995101 ttgggccagt ttccataaag aatctccgct tttgacctta atcgttgctg cttcagctgg 995161 tgtcactact aaagttgtgc cgacaatcgc agatgctgtc agccctgctg ctaatttctt 995221 tttcatctta gctctccttt ttcccccaat gattttgcat ttgctgtttc ttttttatat 995281 cggcacattt gtctcatcgt tttgcctttt tataaaaata gccaaattat cttaacaata 995341 agggggaaaa agggcataaa aaaagaagga atcttaatct attccttcat ttttaaaagc 995401 ttcatgatat cttctttgtt tttgacgagg tcgcgcagtg tgtatttgtc taaaactgcg 995461 aggtaggcta aaagcgcttc attcagcaca tgttttaagc cgcaaaccgg ggaaataaca 995521 cagagattct tgttcgcatc aaaacattca acaatattaa aatcgtcctc cgtttttctg 995581 acaacctcac cgatgttgat gtcttcaggg tccatgccta atcgtatgcc gccgccccgt 995641 ccgcgtatcg tttctacgta gccgagctgg ccgagcctgt atatgacttt catgagatga 995701 ttttttgaaa tagaatacgt ttcggcaatc tgttttatat ttgaaagttc tccgggacgc 995761 tctgcagcca gaaaaatcaa cactcttaat gaataatctg tataattggt taacttcata 995821 ataagacctc agaataagac attttctata tcttatcata atcgattgaa aaatgaaaaa 995881 aaaggaatta aaaaacatgc acccagctgg gtgcatgttt tttgcttaca tgtcattcgg 995941 cggattttgg tttttacggt ttttttcgat ttctgtgttt tgcattttgc gttcaaatgt 996001 agacagataa cgtgatgcaa aatccttacc gccaaggccg aaggataaac caaaagcaag 996061 tgcgaagccg ctaagaacga tgatgaacgc ggaattgacg attgtcgcag cgacacccag 996121 ctgatccagg gccataaaga aagcaagtgc gataatcgta tatttagcaa taggcgctaa 996181 agacttgaat tcctgacctt ttatcatgct tgcgagcact tttctcacca attctcctgc 996241 gtaaaggccg agtccgagaa tgaatactgc gacaaggaca ttcggcagat acgcgatgat 996301 gccggtggca atttctacga ggaagtgcag ccgaacaatt tgaagcgcct cagctgtaaa 996361 gagcagaatg acaatgattt gcgcaatcat accgacaact tgagacaagg acagctttgc 996421 aggcgttccg gcttccatgc ccattttccc taagacagaa tcaaagcctg cgcgatggag 996481 cagtccggac accatggatt tcacccattt tcctgcccag atacccgcta atacaagcac 996541 gatggcaatc atgatgttcg gaagcatgtt taaaatcgta ttcagcatag agacagctgg 996601 ttttgaaatg ccggcgacat ccagctgatc aagcgctgaa atgaccaccg gaatcataat 996661 gagcacataa gcgattgttc cgatgactgc tgaaaggctt gtgtctttta agtaaattga 996721 taaacccata cgtgccgcga atctttcggt gccgatgctt gcaaggaaat tcgtaatgat 996781 atcacggaca aggcgggcaa caagccatcc gattaatacg ataagcgccg ctgcaaataa 996841 tttcggcaga aaagcgagca cgctttccat catatttgta aaaggacctg aaatgccgct 996901 gattttcaaa gaagataaga cccctggcag aaaaacaagc agcacgagat aaaagacaat 996961 ttgtgaagcg gtattgacag cctggtgaat atcttttcct tcagacacca aattccactt 997021 gcgcagtttg tcactcgtgt tcagcttcat cccgattttt ttgacaagga agctcaaaac 997081 agaagctgca gcccatccta acagcagaat gagtccggct ttcagcacgc ttgggatcgc 997141 agctgcaatc gccgaaagca tactgacaaa cggcgatgcc actgttgtca ggtgcaaaat 997201 gttaaagaat aaaataaaga cgatgatcag tgcgataaaa taaacgacct tgcttatgac 997261 tttttccgag gaatagcgtg aaggcttttt cccagcaaag agcttgtcgt cgatttttgt 997321 tttgctgagt cctttgtata ccgctttttc aatgatttta gcaatagccc agccgattaa 997381 taagacgagt aaagcaatga ttacgtttgg cagcttactg agataagaag aaaacacgtc 997441 tgctacattc aattggtatc gctccttttt cgtagtatgg tgtgtgttta cccacttatc 997501 caataagcaa acagatgaat gtgccggggg aattttttct tgcccgagtg agactatcat 997561 cttttgtctg gcgggctcat acattataga taagtccaag taggggggat tcggttgaac 997621 gcggaggaga agaagggatt acagcgggca attgaggaaa ttaccgaaat tgcaaaagga 997681 ttcggccttg atttctaccc gatgagatat gaaatctgcc cggctgaaat tatttataca 997741 tttggcgcgt acgggatgcc gacaagattc agccactgga gcttcggcaa gcagtttcac 997801 aagatgaagc tgcactatga tctagggtta agtaagatct atgagctggt cattaactca 997861 gatccatgct acgctttttt gctggacagc aactcactga tccaaaataa attgattgtc 997921 gcacacgttc ttgctcattg cgatttcttc aaaaacaact gccgtttcca aaacacgaag 997981 cgcgatatgg tggaaagcat ggcggcaaca gctgaacgga taaaacacta tgaacaggtt 998041 cacgggataa aagaagtcga atctttttta gatgcaatcc tttcgattca ggagcatatc 998101 gatccgtcgt tggtccgacc aaagctccaa tggagtgtgg atgatgagga agaggagatt 998161 gaagaggcag ccacgcctta cgatgatcta tggtctttag atgaaaagaa accgaaaaaa 998221 caagtgaaaa aatcgaaaaa accgttcccg ccgcggcctg aaaaagatat cctgcttttt 998281 atcgaggagc attcccggga gctggagcca tggcagcgtg atatattaac gatgatgaga 998341 gaggaaatgc tttatttctg gcctcagctg gaaaccaaga ttatgaatga gggctgggct 998401 tcctattggc accagagaat tatacgtgag cttgatttaa cctctgatga agcgatcgag 998461 ttcgccaagc tgaatgcagg tgtcgttcag ccgtccaaaa caggcattaa tccttattat 998521 ttagggctga aaatatttga agacattgaa aagaggtaca acaacccgac ggaggaaatg 998581 aagaaaatgg gcgtgcagcc tgactccggc cgggagaaaa tgtttgaggt cagggagatt 998641 gaatccgata tctctttcat ccgcaattat ttaaccaaag aattagtcat gcgcgaggat 998701 ctttatttgt ttcaaaaaca gggccgagat tataaaatca tcgataaaca gtggaagtcg 998761 gtgcgcgacc agctcgtaag catgcgggta aatggcggtt ttccatattt gacagtaaac 998821 gacggcgatt atatgaaaaa taacgaactc tatattaagc attggtatga gggcatagag 998881 ttggatttga aatatttgga gaaagtgctt ccttatttat tccagctttg gggaagaagc 998941 gtgcacattg agtctgtgct tgaggataag gaagtcatgt tttcgtacga cggaaaaggt 999001 gttcaccgca gatatttata aaaaagagga tgcagcgttc tgcatccttt ttattttcca 999061 gtttttaaaa tcttaaatat gatgtttgcc tggtccgtat tgttaatcaa tccgcggaat 999121 ttttcttttc cggggccgta cgcgtatacc ggtacttctt cgccggtatg atcggtactc 999181 gtccatccgc tgttggagcg ggtattaaaa atcttgatga tggctttgga ggcccctttg 999241 cttttgtcag cctgtgcagc tgcttcaacg cttttgattt cttcagatgt gactttcaga 999301 ttggcatagc gggcgagcac atctttaacc ggcttgcctt cactgatttt tttggccatg 999361 aattcaggtg ttttcttagc ggagagaatc ggttctgcgt gccaattctt ttccccgttt 999421 gcgccaatgg taaagccgcc ggttgtatgg tcagcagttg caatcacaag tgtatgtttg 999481 tcttttttcg caaattcaat cgcggcttta taggcctgtt caaaatcttt aacctcgctc 999541 atggctccta ctgtatcatt gtcatgggcc gcccagtcaa tctggctccc ttcgaccatc 999601 aagaaaaatc cttttttatt ttggttcagg cgatcaattg ctgaaaccgt catgtctttg 999661 agagacggtg ttttactgtc acggtcgagc gctttagcaa gccctccatc tgcgaaaagc 999721 ccgagcacct gctgatcttt attttttttc aatgcttgtt tagttgtcac atagctgtag 999781 ccggcttgtt tgaattcctt tgtcaagttt ctgtccttgc ggttaaaata agattttccg 999841 ccgccgagca gcacgtctat tttatgtttg ccttttatct tgtcatccat atagctgttg 999901 gcgatttggt ccatgttttt ccgtgattca ttgtgggcgc catatgcggc tggagtggcg 999961 tggttaattt cagacgtggc gacaagccct gttgacttgc cttgctgttt ggcctcttca 1000021 agtacagatt tcactttttt tccgttttta tcgacgccaa ttgcattgtt atatgtctta 1000081 acgcctgtcg ctaatgctgt tccggctgct gctgaatctg taatattata gtcagggtca 1000141 tccggatgcg tcatcatcat gcctgtcagg ttccggtcaa attctgttaa cttcgggtta 1000201 ttcggtgtgt caccgttatt tttcatggaa cggtaggctc ttatgtaagg cgtccccatg 1000261 ccgtcgccta tcatcacaat gacatttctg atctcagctt tgtcttgttt tttggcgctg 1000321 gccttttctg tttgctgaag ctcagctccg gcaaagattc cagctgtaag gacagaaaca 1000381 gcggcgattg gcagaagttt tgatttcata ttttgaaaca aactcatttt tttcatgcct 1000441 cctttaatgt attccgttta tcatgttagg gaaactttgt taaatgcggc tgttgatcat 1000501 gtaaacaata agtaaagcct tgtaaggaaa tgaaaaaacg cttttcgtta tcttgcctta 1000561 tttgatgtaa agcattcatt tttcagaaaa atctttacct ctctgtcttt gcatgatatg 1000621 tttgtttaaa taaaaaaact gcggataacc acagctctcc tcgaatatac tttatcactc 1000681 atttttccga tatatgagcc gaccccgaaa gtttttcatt tatttccttt atgttgaaaa 1000741 acatcccata aaacatgaca aaagcactcg ttttttgtca cctttgcaat gaaaatgaaa 1000801 tatttaatac ccttaaaaac ttttttttag aacgaataat taagaaattt gtcacatgaa 1000861 gtcaagacta tttctgatgg gaatctatcc ttataataga aatcaataag attaatttaa 1000921 aaaaagagat acatatatat agagttaaca tttggggagg aaaatatgaa aaagcaaatc 1000981 attacagcta cgacagcagt tgttttagga tcgacgttat ttgcaggagc ggcatctgca 1001041 caaagcatta aggtgaaaaa aggcgacacg ttatgggatc tttcaagaaa atacgacaca 1001101 acgatcagta aaattaaatc agagaaccac cttcgttcag acattattta tgtgggacaa 1001161 actttatcga ttaacggcaa atctacaagt tcaaaaagca gcagttcttc ttcctcttct 1001221 tctacataca aagtaaagag cggggacagc ctttggaaaa tttcaaaaaa atacggcatg 1001281 acaatcaatg aactgaagaa gctgaatggc ttaaaatcag atttgcttcg tgttggacaa 1001341 gtcctgaaac tgaaaggttc aactagttca agcagctcca gctcatcaaa agtgtcatcg 1001401 tcttcaactt ctacttataa agtgaagagc ggagacagcc tttctaaaat tgcgagcaaa 1001461 tacggcacta cggttagcaa attaaaaagc ttaaacggct taaaatcaga tgtaatctat 1001521 gtcaaccaag tattgaaggt gaaaggaaca agcacaagca gctcaaaacc tgcttcatct 1001581 tcatcgtctt caagcagcaa aacgtcatct acatcactta atgtgagcaa gctggtttct 1001641 gatgcaaaag cgttagtcgg aacgccatat aaatggggcg gaacgacaac ttcaggcttt 1001701 gactgcagcg gattcatttg gtacgtactg aataaacaaa caagtgtggg cagaacaagc 1001761 actgcaggat actggagttc tatgaagagc attgccagcc cgtctgttgg tgatttcgtc 1001821 ttcttcacaa catataaatc cggcccttct cacatgggga tttacattgg aaacaacagt 1001881 ttcattcatg caggatctga cggcgtacaa atcagcagcc tgaacaacag ctactggaag 1001941 cctcgttacc tcggtgcgaa aagattctaa tttttagaga aaacccgttc attggaacgg 1002001 gtttttttca ttagacggag cacaggcgtt ttggttgctc ctaaaaatga aaatgtgata 1002061 aaaaatccaa gaactttttt tctttcttat tttcataaag ggcaatcgcg taagcgccgg 1002121 catagggcag ctgtacagac tgataaggaa ttctgatcat ctgtttctct gctaactcac 1002181 gctttactgt agataaaggc agaaatgaaa ctccgagtcc ttccttgata aaccgtttcg 1002241 ttatatgtgt ttgagtgacc ttcattgttc tcacaaatgg aaatgtcatt ctgacttgac 1002301 ggagcaagtc gtcccagtaa tcaggatgat tgtgggtcaa aagcaggtat tgttcgagca 1002361 cctctttggc atcaatttcg ttgtcttcta tgaaacgctt atcgggcggg gcaacaagga 1002421 cgacagggtc tttgtataag cagtggcagc ttaaagaaga agactgtacc tttaaacagc 1002481 ttagtccgat atctgcttcc ccggctttaa tcagtgacgc gatttccgct gattcgaaaa 1002541 tcgtaaccgc catttctgtt tccgtattca ttgctgtgta ccgcttcatg acagaaggaa 1002601 gcactgtatc tgcaataagc ggagaaaccg cgagctgtaa ggtttgagag tagccttgtc 1002661 tcactctgtg aagctctgcc atgctgtttt cataatcatc aagaagcctg agcgcatacg 1002721 gcaaatacgc cctgccttca tcagtcagct ggatttgcct gcctttacgc tcgaacagct 1002781 tgcagctgat ttctttttct aattgcttga tatgtacggt cacagtaggc tgagataaga 1002841 aaagcgtttc cgccgttttt cggaagttct catattttgc agcggtcaca aaggtgtgaa 1002901 gccatttgaa atccatttct attctccctc tgattaatat ttttaattaa ttccctttaa 1002961 aatattgatt attttttaaa tattatattt actataataa cagaaaagga tagggggaat 1003021 acaaatggta cattacggat taaagggaat tacatgtgta gaaacatcca tcagccatat 1003081 tgatggtgaa aaagggcgtc tgatttacag aggacatcat gcaaaagaca tcgcactgaa 1003141 tcacagcttt gaagaagcgg cttatttgat tttatttgga aaactgcctt caactgaaga 1003201 attgcaggta tttaaagata agctggctgc ggaacggaat cttccggaac atattgagcg 1003261 cttgattcaa tcactgccaa acaacatgga cgatatgtcg gtgctgagaa cggttgtttc 1003321 agcattgggg gaaaatacgt acacattcca tccgaaaaca gaggaagcaa tccggctgat 1003381 tgcaatcacg ccttctatca ttgcatacag aaaaagatgg acgcgcggtg aacaagcaat 1003441 tgcaccttct tcccagtacg gacatgtcga aaactactat tatatgctca caggtgaaca 1003501 gccttcagag gcaaaaaaga aagcgcttga aacctatatg attctggcca cggagcacgg 1003561 catgaacgca tcgacttttt cggcacgagt cacgttatct acagagagtg atttagtgtc 1003621 agccgtcacg gctgctctcg gtacgatgaa aggtccgctg cacggaggtg ctccttctgc 1003681 ggtgacaaaa atgcttgaag acattggaga aaaggaacat gctgaagcat atctgaaaga 1003741 aaaactcgaa aaaggagagc gcttgatggg attcggccac agggtgtaca aaacaaaaga 1003801 cccgcgggca gaagctttga gacagaaagc agaagaggtg gccggcaatg accgtgatct 1003861 tgatcttgcg ctgcatgtag aagcagaagc gattcgtttg ctagaaatct acaaaccggg 1003921 acgaaagctg tacacaaatg ttgaatttta cgcagctgca gtgatgaggg ccatcgattt 1003981 tgacgatgaa ttgtttactc cgaccttttc agcaagccga atggtagggt ggtgcgccca 1004041 tgtactggaa caggcagaaa acaacatgat tttccgcccg tcagcgcaat ataccggtgc 1004101 cattcccgag gaagttcttt cataacatat tttggcgttt attcatttct gtcgtgtggt 1004161 aacgttcagt atcaaccaca tgtctaggag tgatgaatgt gaacccaatg gacagacaaa 1004221 cagaaggaca agaaccgcag catcaggaca gacagccggg cattgagtca aaaatgaatc 1004281 cgctgccgct gtcagaggac gaggattatc gaggaagcgg aaaactgaaa ggaaaagttg 1004341 cgatcattac tggaggcgac agcggaatag ggagagcagc agctattgcc tttgctaaag 1004401 agggggctga tatctccatt ctatacttag acgagcattc ggacgcagag gaaacacgca 1004461 aacggatcga aaaggagaat gtccgctgcc tgcttatccc gggagatgtt ggggacgaga 1004521 accattgtga acaagctgtg cagcaaacag tggaccattt tggtaaactc gatatcttag 1004581 tgaacaacgc cgctgaacag catccccagg acagcattct caatatttca acagaacagc 1004641 tggaaaaaac ctttcgcaca aatatttttt ccatgtttca tatgacgaag aaagctttgc 1004701 ctcacctgca agaggggtgt gccattatta atacgacatc gattaccgct tatgaagggg 1004761 atacggcgtt aattgattat tccagcacaa agggtgcgat tgtttccttt acgcgttcca 1004821 tggcgaagtc gcttgcagat aaaggcatca gagtgaatgc ggtggcgccc ggtccgattt 1004881 ggacaccgct tattccggcg acattccctg aggaaaaagt gaaacagcac ggcttggata 1004941 ccccaatggg aagaccggga cagccggttg agcatgcagg cgcctatgtt ctgctggcgt 1005001 ctgacgaatc ttcctatatg acagggcaga ccattcatgt gaatggcggc cgttttattt 1005061 caacgtaatc aacgaaaaac cagctcaaga gctggttttt tgtgtggtga aaaatttcaa 1005121 aataaaaaat ttgtcgattt ttctaacaat tttgttttca tttttgcaat tttatatata 1005181 atattgagta ggagaaagga atgattcgcg accagtacaa atatagtaga aaaaaaagaa 1005241 taatgaccat tgttactcat gaattcagaa aattcaaata aaatatataa aaatagatga 1005301 tcgggagttg aaggggaatg aaagggagcg tttttaggaa gaaaagcatt caggatttaa 1005361 tcgctgcgac gagcggggaa aagtctttaa aaagagaatt aggggcattt gatttaacgt 1005421 tgcttggaat cggcgccatt attggcacag ggatttttgt tctgacggga acaggcgcag 1005481 tcacggccgg tcccgggctg acgatttcat ttgttgtggc ggcgttggct tgtttattcg 1005541 ccgccctgtc ttacgcggaa tttgcgtcaa gtgtgcctgt ttcaggttcg gtgtatacat 1005601 tcacttatgc gacattggga gagcttatgg cctttattat cgggtgggat ttaattttag 1005661 aatacatgct ggcggtaagt gcagtgtcgg tcggctggtc tggttatttc caatcgtttt 1005721 tatcagggct tggcattcat cttccggttg ctttaacagc ggcaccgggc gcagtgaaag 1005781 gcacctttac cctgtttaat cttcctgcat tcgtcattgt aatggcgatc acatatttgc 1005841 tttatttagg catcaaagaa tcaaaaagag tcaacaatat catggttatc ttgaagatac 1005901 tggttgttct gctgtttatc gcggtggcag ccgtttacgt gaagccgcac aactggcagc 1005961 cgtttatgcc aatgggcttt ggcggcgtgt tcagtgcagc ggcgctcgta ttctttgctt 1006021 ttatcggatt tgacgctgta tcctctgctg cggaagaaac gaaaaatccc gcgaaggatc 1006081 tgcctaaagg cattattttc tctttactgg tctgcacgat tttatatgtc accgtatcag 1006141 ccatcatgac tggggttatc ccgtttgctc aatttgcggg tgtggatcat ccggtttctc 1006201 ttgttcttca aagcgcaggg caaaattggg tggcaggcat cattgatatt ggcgccgtgt 1006261 tgggaatgac aacagttatg ctcgtgatgc tttacgggca gacccgcgtc atgtttgcca 1006321 tgtcgcgtga cggacttgtg ccgggttcac tttctaaagt gcatccaaag cacaaaacac 1006381 cttatgtagc cacttggttt ttcggaacga tgtcggcgct tctcggctca cttgttccgc 1006441 tggatgaact tgcaaagctg gtgaacatcg ggacgttgtc ggcatttgtc ctgatttctg 1006501 tggcagttat cgttttgaga aagaaacagc ctgatcttcc gagagctttt aaatgcccgg 1006561 gagttcccgt gatcccaggc ctggcgattc tgttctgcct gttcttgatt ttaaatctgg 1006621 gatgggtgac gattgtccgc ttcctagtgt ggctgttaat cggcttggta atctatttcc 1006681 tgtattcaag aaagcattca aaattaaatc aataaccttt tgataaagag agcggccata 1006741 caggccgcct cttttctgtt cttggcaaat gaatctatag aaatgaagac aaaaataaga 1006801 gataatatag gctggaaagg aagtgacgtt tattgtctga gcaaaaacca gtccaatggg 1006861 cttcgaaaat tggtttcgtc atggcagcgg ccggctcggc tatcggcttg ggcgcgattt 1006921 ggaagttccc ttacgtagcg gggaccaatg ggggaggagc cttttttctt atcttcgtgt 1006981 tatttaccat cctcttaggc tatccgcttt tggtggggga atttattttt ggaagacgga 1007041 accagacgaa tgccattgat gcatataaaa aagaagcgcc gcgatcagct tggtttctta 1007101 cggggtggat cggcgtagcg gcgtgtttct tagtgctgtc gttttacagt gtaatcgggg 1007161 gatggatttt gctgtatatc gtgaaaacag cgtcaggatc actgtccggg ctttctcaag 1007221 cacagtatgg cgctcttttt gcttctatta tccaaaatcc ggtgcagacg ctcgcggctc 1007281 agcttgtctt tatggcactg actgtactcg ttgtcgcaag aggggttcaa aaagggattg 1007341 aacgggtaag cgcggtgatg atgccgattt tgtttttatt gtttattctg ctcgttcttc 1007401 ggtctcttac gcttaatggt gcaatggaag gcgtaaagtt tctgcttgtg cctcatttcg 1007461 gcgatctgac tccggaatcc atattattcg cgctgggaca ggccttcttt acgttaacac 1007521 tgggggtttc ggtgatggtg acctacagct cctatttgcc gaaaacacaa aatatccctc 1007581 gttcggcagc ctccattgtc ttgatgaata tcattgtgac actcttggca ggtttggcta 1007641 tttttccggc ggttttctca ttcggttttc agccaaatga aggaccgaca ttgctgttta 1007701 cagtgcttcc ggccgttttt gaacagcttc cgttcggcac attgtttttt atcggctttc 1007761 tcgttgcatt tttatttgca gccttaacct cagcattttc gatggttgaa attatcgttg 1007821 ccacaatcgg aaaaggggac gaaaagaaga gaaaaaaact gtcatggacg agcgggcttt 1007881 tgatcttttt ggtcggaatc ccatgctgct tgtcttatgg cgttttgagt gatgtgcacc 1007941 tatttggcaa aacgtttttt gatattgccg attttaccgt cagcaatgtt ttgatgcctt 1008001 caggcgctct gttaatttct ctatttatcc cgctgaaaat ttcgaaaagc gaactcttgg 1008061 ctgaaatgcg aaatggatca aatgcaggta aagcattctt ttacacatgg ttttatttgc 1008121 ttcgttttat cgtgccgctt gccattatta tcgtgttctt aaatttaatc ggaattttat 1008181 cattttaaaa aacaggctcc gtttccgggg cctgtttttt atttaataag atgatatcaa 1008241 cggtgcccat gccgttttca gtttttggat gccgagcctg atgtcctctt ctgacaaacc 1008301 gccataaccg attaagacag aagtaaaagg cgtctgttct atatatgagg gagacacggg 1008361 atagagggtt acaccgtggt cagcggctgc ttgtattgct tcttcctcac ttgctggaaa 1008421 caaaaggcgc agcagaatgt gaagccccga gttcttaccg agaatctcaa cggtgtttcc 1008481 cagttcagag cgaatggctt ctaacaggac agcgtgtttt tttcggtata agcttctcat 1008541 tctatttatg tgtttttgcc actctccggt ttcgatgaag tctgccagtg ccaattgcga 1008601 gtgggcagaa acggtctgct tcattaactg aacattgttt tggatcggtt ccatgagttc 1008661 agggggcaca atcatgaagc tgagccgcaa ggaaggcaga agtgactttg aaaaagtgcc 1008721 cagatatatg actctgccat tcggatcaag accctgtaaa gacggaatgg gatggccgct 1008781 gtagcgaaat tctccatcgt aatcatcttc tataatgaat gaatttgttt ctgccgccca 1008841 tgccagcagc tcctgtctgc gggtaatcgt cataatggtc ccaatcggaa actgatgcga 1008901 aggagtcgta tacatgagat aaggattctg acggtagagc tcatccggca ggacgccttc 1008961 tgcatcagaa caaatcggag tgacatccat gtgatttgct tcaaacatcc ttcttgaacg 1009021 gtgaaagccc ggttcttcaa agccgatttt tgtacctggc tttagcgaaa ggcaaagatt 1009081 ttgcagaagc acggtggttc ctgcgccgat gataatctgg ccgggttcac aatttactcc 1009141 ccgagacagc ctgacgaatc gggcaatcat gtgcctgagt tcgtattctc cttgagggtc 1009201 gccagaggtg tgaaacgatc cggaatagcg atcaagactt tttactatgc tttttctcca 1009261 tgcgttaaag ggaaagaggg tcggatcaac gctgccctga tggaagtcaa tagcaggtgc 1009321 gtttttttga tgtaatcccg gctgtacaga ctgctgaaaa tggtcaggag ctgtcgggaa 1009381 tcctggttct acttccgccg cgaaccagcc gattttcggc ttgcttttga catagccctc 1009441 agcagttaat tgctcataag ctcgttctat agttgccgtg ctgacatcga gcaagctgga 1009501 gagcctgcgt tttgacggaa gtcttgttcc ctttgtgatt cgcgcatgtg aaatttcttg 1009561 tttaaaaaag gtataaagct gttcatacag cggtgttttg ctctttttat caagaaacgg 1009621 cgtaatatcc atctcatgtc tcctttgtag ctggcatggt cattttttct gatattggct 1009681 atttggcaaa tgccatttat tagctatgat cattgtaacg aaaggaaagg ggattgagaa 1009741 gatgatccat atgaaacaat taacctcgaa agaagaatgg gctgagtcgt atccgattat 1009801 gagtgaattg agaacagaac tggatataga gacgtattta caaaggcttg aagcctgtgt 1009861 gcagaaagaa tcgtatatgc tgtttgcctt atatgaaaat acagcaatca gagcgctgtg 1009921 cggggctctg ccgagagttt ccattcataa aggagagcac ttgtggattg cggatcttgt 1009981 tacaacggca ccttgccgat caaagggata cggcaaaatg cttttggatt atgcctcaga 1010041 ctgggcgaga aaagccggac tcggttttgt cagtctttca tctggccttc agcgtaaaga 1010101 cgcacatcga ttttatacag ataaaatggg ttttactata gaaagttatt tgttccgaaa 1010161 accggtataa cgaaaaaaga cgcctgaaaa ggcgtctttt ttaaaagcca aactgtaaat 1010221 tcgtatctac agatacaatg gtatacacac aaataatcac aaagagatta aggatgacgc 1010281 cgagcaggcc tggacctgtg cgccctctct tgatgaagag ttcaacaacg ccgaacggaa 1010341 cggcagccat ggcgaacgga agcatttgat aggaataaaa cgtgacgttg ctgataatgg 1010401 ccaaattcag caacagcagg gacagaaccg ctgtcccgac agagatccag ccgaatacat 1010461 tgtgttcttt aaaaattctt accagttcca taattccacc tcgccgacat tcgctgattt 1010521 tacagattta tttttcagca tgcgctggat ttccttggtt ggccctgtaa cgaccgaacc 1010581 gtatacattg acaccgtttt tctctacata atctaatcgg ttatctacat tcaggtcttt 1010641 ccgttttgaa atgacctgag cccatttttc gtgtttggac atgaatttca gggcgttgat 1010701 aaactgatcg ccattcgact tgccttttgt attaagggcg gccaagaact ttgaatcctt 1010761 tccaggatag ccaagaggtt ctgtggaagc tgtcttattt gtgtttttct ctgtttcgat 1010821 tgcgttccac aaaaagctca catcatagcc tttgaatttg ttatacacgt cttttgtcgg 1010881 atatgcacgg tcatatgaaa ggtagacctc tgataccgtt ccttcaggca atgtgcttaa 1010941 cgttttttct gcttttgcgg tcgtttgttc agacttgttt gaaggatgtg taaagtaatg 1011001 gccggtttta ttcacttcta agtcatagta gtttactgcc ggcgctttta ctttgttata 1011061 aaacatttca acccgttcat tccctacggc agccgtcttc gtgccaatct gcttttgcag 1011121 cgggaattcc gtattcattc caaatagctt cacttggctt ttcagtccgg aagtatcaac 1011181 aagaacattc ggcatggtca gggctacagt gactgcggca gtttccataa actcattgcc 1011241 ggtgctgtgt tttccaccca ttccgtaata gaggtagctt cccagcgtac aaagcggcaa 1011301 aatcatcaat gtcgaaatga cggcaagcac agaaattcgc aaataagact tgcgtttgcc 1011361 gtaggctaaa atcgcttttt gtttttcagg actgatgctg agatcccaat cgttatcgtc 1011421 ctctagttcg ctgtcaatca gttcctgata tacttcaagc ttctcgagtt cttcctcaaa 1011481 tgcagtcatt tcctggtcgc tcatttcccc atttttatat tgatcaaaac gctttttaaa 1011541 ttcttcattc atcattaaca cctctattat aaagtgcttt cagccgctgt ctggcacgaa 1011601 ataaaacact tttaaaattc gcctctgaaa tattcataat atgggatgct tctttgtagt 1011661 ttaactcttt taaataatat agcgttaagg cctcccgata attatcgggg agctcggaca 1011721 tataaccagt cagcacttcc tttatctcta cctgatgggc aggactttga acagcatttt 1011781 gaaagaggct tccgattaag tcatcagaaa tggttacttc tttcttatgc tttctgacgt 1011841 aatcaatgaa ggcgtttcgc gccacttgaa aaagccaggg ctttactttg ctgtgatcat 1011901 aggagtgaat gtgtatgtat gcccgcataa aggtttcctg cagtaagtct tcagcaagat 1011961 gcttgtcttt tgtcatggag agcaggaacc tgtaaacatc attcatgtac atttggtaaa 1012021 tttcatcgat cgtcactgcc ttttctcccc tctatgttat acacgcataa gaaaggttta 1012081 aagttgcaca ttacatgcaa acggcttttt tatacctaat caaacaccat tactatatag 1012141 tacccaaaaa tggccgcaaa agatagtgcg gagaaaggtt taacattttt tccagagggg 1012201 aaaagatagt gaaaaagtga aggagtggca caatggaata taccagtata gcagatacag 1012261 gaatagaagc ctccagaatc ggcctcggca catgggccat tggcggaacg atgtggggag 1012321 gcactgacga aaaaacatcg attgaaacaa tccgcgccgc tcttgatcag gggattacac 1012381 tgattgacac cgcaccggct tacggcttcg ggcagtccga ggaaattgtc ggaaaggcaa 1012441 tcaaagagta cggcaaaaga gaccaggtga ttctcgcaac gaaaacggct ctggactgga 1012501 agaacaacca gctgttccgc catgcgaaca gagcgagaat tgtagaggaa gttgagaatt 1012561 ctttgaagcg gcttcaaaca gactatattg atctttatca ggtgcattgg cccgatccgc 1012621 ttgtgccaat tgaagaaacg gctgaagtca tgaaggaatt atatgatgcg ggaaaaatcc 1012681 gggcgattgg cgtcagcaat ttttcaattg agcaaatgga tacatttcgc gccgtcgcac 1012741 ctctccatac gattcagcct ccatataatc tgtttgaaag agagatggaa gagagtgtcc 1012801 ttccttatgc gaaagataac aagataacaa cattattata cggcagttta tgcagagggc 1012861 tgttaacagg caaaatgact gaagaatata catttgaggg cgatgatctg cgtaatcacg 1012921 atccaaaatt ccagaagccc cgctttaaag agtatctttc tgctgtgaat caattggata 1012981 agctggcgaa gacacgttat ggaaaatcag tgattcactt ggctgtcaga tggatcttag 1013041 atcagccggg agcggatatc gctctttggg gagcaagaaa gcctgggcag cttgaggccc 1013101 tatctgagat tacaggctgg acgctgaaca gtgaagatca gaaagatatc aatactatat 1013161 tggaaaatac gatatcagac cctgtcggac cggagtttat ggccccgccg accagagagg 1013221 aaatataaca aaagctgagg gcgaatcctc agctttttgg cgtttaaacg agagaaatct 1013281 taaaaattag taccaggtaa taaaaaatat tgttataata gatgacagaa agaatcattg 1013341 attacgacaa aggaagtgcg atatgtataa gttttgtgca aatgctttaa aagttattct 1013401 ttctcttcgc ggaggagtga aggtgtataa caaagaaaac cttccggccg attcaggttt 1013461 tgtcatcgcg tgtacacatt ccggctgggt tgatgtgatt acactcggag tcgggattct 1013521 tccttatcaa atacactaca tggcgaaaaa agagcttttt caaaataaat ggatcggttc 1013581 gtttctgaag aaaattcatg cctttccggt agatcgggaa aatcccgggc caagcagtat 1013641 taaaacgccg attaagctgc tgaaagaagg agagatcgtc ggtatcttcc caagcggaac 1013701 aagaacctct gaggatgtgc ctttgaaaag aggtgcggtg acgattgcgc aaatggggaa 1013761 agcgccgctt gtccccgctg catatcaggg cccttcaagc ggaaaagaat tattcaaaaa 1013821 aggaaaaatg aagctgatta tcggtgagcc tcttcaccag gctgattttg cccacctgcc 1013881 ttcaaaggaa agacttgcag caatgacaga ggctttgaat cagcggatta aagaactaga 1013941 gaataaactt gatcagctat aaggcgttct gagagattgt cctgaaactg tgaaaataag 1014001 aaaagcaccc tatacaaggt gcttttctta ttatgcttcc tgctggttag ctgtctccag 1014061 aagttcttct tcttgaagct ttttcacttc aatatatgcg acgtggtggc cgtcaatttc 1014121 attaatgatg aattcgcagc cctcttcgat gatggaatca tctttttcaa catcgtattt 1014181 ttgagtaagg aaccagccgc cgattgtatc gacttcttcg ttctctaaat ggatgcctag 1014241 caggtcgttt acttggtcaa ttaacacttt tccgtcaaga atataatggc cttcgccgat 1014301 tttgcggatt tcgctaattt catcaatatc aaattcgtcg cggatttcac cgacaatttc 1014361 ctcaatgatg tcctcaaccg tcacaagccc ggcagtaccg ccgtattcat cagacaaaat 1014421 ggccatgtgg accctctctt tttgcatttt gacaagcagg tcttggatcg gcgcagattc 1014481 aatgacatga atgatagggt tgacgaattg agaaatggtg gaatcaacag atacctcacc 1014541 gctgatgcag gcggtcagca cttctttaat gttaataacc ccgataatgt tatctttatc 1014601 gccctcttcc acagggtagc gggtatattt ttcaatctga atgatgtcca tcatttcaga 1014661 aatcttgata tcatgcggaa ggctgacaat ttcggtccgc ggaatcataa tttctttcgc 1014721 gagcctgtcg tcaaattcaa agattttatt cacatattta aactctgatt ggttgatttc 1014781 accgctttta tagctttcag acaaaatgat tcgcagctct tcttctgagt gagccagttc 1014841 gttttctgaa acggtctcca ggccaaatgc tttggtcaat aaccgtgcgg aattgttcaa 1014901 aagccaaatg aatgggaacg cgatgcggta aaaccaaatc agcggtttcg caaacagcat 1014961 agacactgct tccgcctttt ggatagcgac tgttttaggt gcaagttctc cgacaacaac 1015021 gtgtaagaac gtgataatgg catacgcaaa aataaacgat atgacatgtg aaagggaacc 1015081 tggaacgttc atttggacga aaagcgggtg aagcagcctt tcgatcgttg attcacctaa 1015141 aacccctaat ccgatggaag tcaatgtaat tccgagctga cacgcagata aatattcatc 1015201 aagatgcgtg gtcacttttt ttacggctat tgctgcttta tttccttccg cgatcagctg 1015261 atcgatccgt gagcctctga ttctgataat ggcaaactca gatgccacga aaaatgccgt 1015321 cagggcgatt aaaacagcaa ctaaaatcaa attcactatg tccaattaga accttcactc 1015381 tagcaatgag aatgaaggta acacctcctg ttagataaaa tggttttaac ttaacagcag 1015441 cataaatgat tggaacacgg cgagcttttc aggcgggagt ttgcttttca gcttgtcacg 1015501 atcctcgggc ttcagccgtt caaaccgatg caagattccg gagatgtttt gattcatatg 1015561 atcaatttct aatgccagat ttccaatttc atcatcaagt ttagctgaag agggaaactg 1015621 gttctccagt cgatctttaa tatcggacag ggccaatcgc tgcttcttgc aatctacaat 1015681 aaatataagt cgtttgagtg cattttcgtc gtagtaacgg taatttgaac aggatctggc 1015741 cggcgtaagc agaccgagat tcgtataata atcaactgtc cgtttcgtta ctccggcgag 1015801 tgccgctagt tcactgatgc gataagtctc agccccatct atatccctcc caaccatcac 1015861 gttatagtta tgagaatagt ttaatatatg aacggtgtct tgcacaagtt tattgttttt 1015921 tttagaccgg aattggaagt tgtggaattc atcatctgat tgaagtaaca taggaagata 1015981 gaattttcaa atttttatat gcggaaggga cagatgaaat tggctgggtt atcccgggaa 1016041 gttgaagaaa acttaaataa aggatcatgg attcgcaagc tgtttgatga aggtgcaagg 1016101 ctgaagaagg agttcgggga agaccaggta tttgattttt cactcggcaa cccgattgtt 1016161 gaaccgcctg aagcttttaa gagagcgtta atagaggaag ctgaaaaagg cagccacgga 1016221 tacatacaaa accaagggct tcttgcagcg agagaaaaag tcgcgcaatt tctgggctcg 1016281 cgttttgaag ctgatttctc agcggagcgc atcgtcatga cggtgggcgc gggaggcgct 1016341 ttgaatgttg cgttaaaaag catcgtaaac cctggggaag aggtcattat tcttgcacct 1016401 tattttgccg aatataagtt gtatattgag aactacgggg gaaaagccgt cagctgcccg 1016461 ttgacaagcc ggtttgagat cgacattgaa gcggtaaggc aatcgatcac tccacagacg 1016521 aaagggctga ttctcaatac accgcataac cccacaggca ctgttctcag ccagaaaaat 1016581 atagacgatt taggcgcttt attaaaagaa atagaagaga agagcggcca gacgatttat 1016641 gtgctgtttg atgaaccgta cagtcaatta atctatgatg aagagctggc aaatccgttt 1016701 caatcgtacc atcgtgtgat attggccagc tcattcagta aagatctcgg catagccgga 1016761 gagcggctcg ggtatatcgg attggacagc cgaatgccgg atgcggacct tttgatcaac 1016821 gcttttgtgt attgtaatcg aacgcttgga tttgtgaatg cccctgtcat gatgcagcgg 1016881 gctgtggcac gaatggatga tttaagagta gacgcgagcg cttataaaga gcgccgggat 1016941 ttaatggtag acattttaaa agaagccggt tttgaatttg aaatgccaaa gggaggtttc 1017001 tttgtttttc cgaaatcgcc gattgaagat gaagttgcat tttgcgtgca tgccgcccaa 1017061 aaatacaaat tattaattgt gccgagcagc ggttttggaa tgagcgggca tttccgatta 1017121 tccttcagtg tgccgatcga gcagattaaa aactcacggg acattttcat ttctttatat 1017181 aaagattttg cttaagaagg caaagaaaag aaaacagttt tcaaggctgt tttcttttta 1017241 tatccgcaaa atccttcctc ttccaatcca gacaggcgca gaattgacaa gcaggcatgc 1017301 agttaaggct ttcttcatga taaaagtcta aaaattaaaa atcatttttg gaatgagttg 1017361 tgttacaata aaatatacaa tttataatca aactttgact tttggaggtg gtatgatggg 1017421 gccctctgct taggcaacaa tacaccgcgt acctcaatgt taaggaaaaa tgattatatc 1017481 aggaggtgac tccttatcct ttgttgagag gatagggtta aatggacgat attgacagtc 1017541 tgattttaat tggcgtgctc attgctttaa ccgcgttttt cgttgcaagc gagtttgcga 1017601 ttgttagagt gaggagatcc agaatagatc agcttatcac agaaggaaac aaacgggcga 1017661 tactcgcaag gcgtgtcatt acagatttgg atgaatattt atccgcatcc cagctaggca 1017721 ttacattgac atcaatcggg cttggcgtac tgggtgagcc ggcctttgaa cggctgctgc 1017781 atccactgtt tgaaccgctc ggcttgccgg actcggtttc acatgcagtc tcttttgcag 1017841 tcgcgtacgg cttgatcacg ttcctgcacg ttgttgtagg tgaactggcc ccgaaaacgg 1017901 tcgcgattca aaaggcagaa cagctgactt tactgatagc gggccctttg cgtttattct 1017961 atttgctcct gtttccgttt atttggatcc tcaatggatc ggcgcggctt ttatgcggga 1018021 tgttcggttt gaagcctgcg tcagaacatg atggttccca ttctgaggaa gaactcagga 1018081 tgctgttatc tgagagttta aaaaacggag agattaatcc gtctgaatat aaatatgtga 1018141 ataagatttt tgaatttgat aatcggatcg ccaaagaaat tatgataccg cggaaggaaa 1018201 tggctgctgt gtcaactgag atgacgatgg ccgagatgct tgaagtcatg ctgaaggaaa 1018261 aatacacgcg ctggccagtc acagatggag acaaagacag tgtgctcggt ttggtcaata 1018321 cgaagcattt gttttctgat ttgctgttta tgacagaaga agaacgaatg aagatgacga 1018381 tccatccgta tgtgaggccg gtcatcgaag tgattgaaac gatcccggtt catgacttgc 1018441 tgattaaaat gcagcgcgag cgcattcata tggctatatt gtcggatgaa tacggaggaa 1018501 cctcgggact tgtgacgaca gaggatattc ttgaggaaat tgtcggagag atccgagatg 1018561 aatttgatga agatgaacag ccgctgatcc aaaagcttgg cgacggccat tatgtgatgg 1018621 atggaaaggt tcggatcgat caggtgaaca gccttcttgg cgcatcgatt caagaagacg 1018681 tcgatacgat cggcgggctg atattaaaag aaaacatcga tattgaggct ggtgaatcca 1018741 ttcgcatcgg ttcatatacg ataaaggtgc tgaagatgga cggccgatta atcaagcaaa 1018801 tcgatataaa agaagaagcc ggcaacacaa ccgggattac ggcgcaccac aagctgccgc 1018861 tgcccgagcc tgtgatgctg aacagtgcaa ccttgagcga gaaataagct caaggttttt 1018921 ttatattgtg attgtccagc cgcaccaaaa tgcaaaaagc gacccgcaaa gtgtcaggac 1018981 gatgtacaag atgctttctt ttacacgttt ggccataagg agttgaatag tttcaacgct 1019041 gaatgtggaa aaggtcgtaa aggcgccaaa aaaccccgtg ccaatgataa gcgagaccga 1019101 agcatttgca acgtgaagtc ctgtaaatat tccgagcccg agagctccga gaatattgac 1019161 tgtcagtatg ccaatgggca ggctgagacc tttggttttg gcggttatga cattgccaag 1019221 ccagaagcga agcattgcgc caagtccgcc ccctatgaaa atacccgcta gtgtcatttt 1019281 tcctgcagcc cctttctttg ctgaatgcct gctatgcgcc gtcccacaaa aacaccaatc 1019341 agtgcaaata tgatccctga tatcaatgag gctgccacat ataaaagagc caatgagggt 1019401 tgtccttgca aaagcatcac tgtttcctta gaaaacgtgg acattgttgt gaagcctccg 1019461 caaaagccgg tgcctaaaaa agccgacagc agaggccgtt ttgccccgat cataaaaaat 1019521 ccggtcaaaa tgcctaatag aaggctgcct gccgcatttt ccagccaggt tgccgccggg 1019581 aactgaccgg tgtgtatcca taagtttaat ccgtatcgga ggcaggcgcc aagcgcgcct 1019641 ccgataaaaa ccgcgctata tattttcatg tttgccatcc tttatgatga aatccgggta 1019701 atctgtaacg atgccgtcca cgcccatggc ttgtaatttt gccgctgtct tttgattgtt 1019761 gacagtccat gcaaatatgt ttaagccatt tttattgatg gagccgatca tcagacggtt 1019821 aagccgtgtg tgttttatat tgacatagtt tgcaaaagag cggaaggcct tcatctgatt 1019881 tctggacagc atgccaaagt tgggccttgt aatgaccgct gtcggaatcg aaggataaag 1019941 ctcgcggaac ctttggacgg agcggaactg aaaggattga acaatattat tgatagaaaa 1020001 agaaaattgc cctaatagct gtcccacctc ttcttcaatt ccgacttgag acggatggcc 1020061 ttttagttca attaaaaggc cgattttttt gtggtagcgc ttgagcaccg cttccagggt 1020121 tggaatacgc tctccttgaa aagcgggacc gtaccagctt cctgcatcga gtttttgcaa 1020181 ttcctccaag gtaaaatcct taacaaagcc cgatccgttt gttgttcggt caaccctgtc 1020241 atcgtgtatc acaacaatct gcctgtcttt tgtaagctgg acatccagtt cgatcatatc 1020301 tgcattcatt ttcaccgcaa ggtcaaatgc ggcaatcgta ttttccggag cgtagccgga 1020361 tgctccgcga tgggcaatga tgtacaagct aagtcagctc ctcgtatggg catttctgtt 1020421 attgtatcaa atccatatat gcaccgcgat acaaactggt gaattttttc tgccatatcg 1020481 gaatggtccg ggctgaggaa tgcgtataac taaaaaaaga cactcagcgt atcagaacac 1020541 atttcgtcag aaaattaggt ctttcgacat gttcacaaca aaatatgatc ctttataata 1020601 gcaaaaaagg aggcgagatc atgggaaaag ggagaatcag agtggaggaa agaattaaag 1020661 ccgaaacgga tgctgaaatg caaaaagcaa ctctccttga tcagacacaa acgaaaaaag 1020721 gtaagtgact gtccctattg aatctggctg atagatgaat tgagaaatga ccccggcgtt 1020781 tcgccggggt tttgtgctgc ataagacatt taaatgaaca tccttacgaa tattttagta 1020841 taataaacaa ttgattggga tagaggggag acagtcatgc cggattatct gcagcagtat 1020901 tttacgcttg ataacatcat acaaatcggc atcagcttgg cgattttgct ggtgtttctt 1020961 atacttagaa aattattcac aagatatttt tttaacctgc tttttaattt gacaaaccgg 1021021 ccgaaaacag aaatttttaa acaggtggtt ctggcgtttg ataagccggc cagatggttt 1021081 tttgttgccc ttgggctgtt tttagcgatc cggtattcac cgtttttaga tgagcaaatg 1021141 ccggtcatca gcaaaatata ccgctcactg attgtggcgc tcttgtgttg gggtctttgt 1021201 aatttgaccg caacatcgtc gtttatcttc cataaggtga accagcgctt cgagcttgac 1021261 atggatgaca ttctggcccc gtttttatcc aaattgctcc gttttgtgat cattgcgctc 1021321 agtgtcagtg tgatcgctca ggaattcaat tatgatgtca acggatttgt agcgggcctt 1021381 ggtcttggcg gactggcttt tgcgcttgcc gcgaaggata ccatcagcaa cttcttcggc 1021441 ggtattatca ttattactga aaagccgttt acaattggtg actgggtgga gacgtcgaca 1021501 gtaacaggat cagtcgagga tattaccttt aggagcacga gattcagaac agcacagggg 1021561 gcgcttgtaa cggtgccgaa ctctacgctg tcgatggaag cgatcacgaa ctggacaaga 1021621 atgaccaaac gccagattac gttttccatc catgtgtcct acgctacgcc gattgagaac 1021681 cttgaacgct ccattcattc tctcagaaca atgctcttag agcatgaggg cgttgataat 1021741 gaaataatca tggtcaactt tgatacgttt gccgacagct actacaattt attttttaac 1021801 ttctatacaa aaacgacggt ttgggctgaa aaccttaata ttagagagga tatcaactat 1021861 aaaattattg agattttagg tgcagaaggc gttcagtttg catatcccgg ccaaatggtt 1021921 gttgtcaagc aaaagcacga aagcgaccaa ttccaggtga atctaaataa agaggaaaag 1021981 gaacgggctt aaaagagaga cttcgtctga cagaggcgga gtctttttca tggtaaaata 1022041 agagaaaaag gcggtgttga gttggaaaca ttcaaaagta ttctacatga agcacagaga 1022101 attgttgtgc tgaccggagc gggaatgagc acagaatcag ggatccccga ctttcgttca 1022161 gcagggggca tttggacgga ggatgcctca agaatggaag cgatgagcct tgattatttt 1022221 ttaagttatc cgcgtctgtt ttggcccaaa ttcaaagaat tgttccagat gaaaatgagc 1022281 ggcagctttg aaccgaatga aggccatttg cttttagctg agctggagaa gcaagggaag 1022341 caggtcgata ttttcacgca aaacattgac ggtcttcata aaaaagcggg gagcaggcat 1022401 gtgtacgaac tgcatggttc tatccagaca gcagcttgtc cggcatgcgg cgcccgatat 1022461 gatcttcccc atttgctgga gcgggaggtg ccggagtgca cggcggccgg aaacaatggg 1022521 gacatttgcg gaacggtatt aaaaaccgat gttgttctct ttggcgatgc cgtcatgcac 1022581 tttgacaccc tttatgaaaa gctggatcaa gcagatcttt tattggttat cggcacgtct 1022641 ctcgaagtgg ctccggctag atttgtgcct gaggatgcaa gcctgattcc cggcatgaag 1022701 aaagtcatca taaaccttga accaacgtat tgcgacagct tgtttgacat ggtcatccat 1022761 caaaaaatcg gcgagtttgc ccgaagtttg ggcatgaaaa agtgagccgc tttatgcgcc 1022821 tcactttttt attcatgaac aggaaccatt gtgtcctcta acactccgaa ggaatagcct 1022881 ttttctttta atttattgat tagtaccggc agcgcattta cagtagcagg aagatcatgc 1022941 atgagaatta catttgggcg gcttgaagag ctgtgttcca tattctcaag ctgctgtaat 1023001 acggcggtca catactgtga attccggtat ttccagtcca tgctgtcgat cgtccaatcc 1023061 cagtacacaa acccatcttt ctccagattg cgaatttgtg aggcggttag tgacggcttg 1023121 cttccgtatg gcgttctgac aagatcggtt ttatatcctg taatgtcctg cagcgtgtca 1023181 cgcgcctcct gcatttcttt tagcggagat gtcggtgttt gatagaacaa tctgttattg 1023241 tgggtaacgc catgtaaacc gagtgcgtgg ccttcctttt ctgctctttt cacagcctgc 1023301 ttgaattcgt tcatccgcgg tgacagcata aaaaacgtcg cttttacatc agcgcttttc 1023361 agtacgtcga gcaagcgggt tgtaacggct gaagggccgt cgtcgaaggt taagtaaacc 1023421 gttttatctc ccatgttctg ctttgtctgc agatgtttta tcaggagatc gggggagtcg 1023481 tttttcagct taaggctttc cttctcatct cgaagctggc cgtttgttgt gacagtgact 1023541 tcctttgctt tcgttgaact gttggaataa cccaaaatca ccataagcaa aagcagcaca 1023601 cataaaactg ctaaacttgc aaatttaaaa gcaagcgaaa ctgcagaagg agaagcctct 1023661 cctctcgttt gtcgcataac aatctctcca ttggcataaa atctctacat aatgctgtac 1023721 agcaggcagc ttatgaagat gccttatgtt tacaacctat gtattaccag tcaagtatac 1023781 aggaataaaa ctggaaagca catagaaaat ttgtcgaaat gtcagatttt aaggaaaaaa 1023841 taaactcctt tccgctatag atctcttgat ctttctgttt ttcagcttgt ccaatatggt 1023901 agaattagtg ataatgacag cttgaatgac atcagggaca tctcgaaaag ggagggcttt 1023961 tatgaaggtt ttagtcaatg gccggctgat tgggcgcagt gaagcatcaa tcgatttgga 1024021 agatcgcggt tatcagtttg gtgacggcat ctatgaagtg atcagggtgt acaaaggagt 1024081 attgttcggc ttacgtgagc atgcagagcg ttttttcaga agtgctgctg aaatcggaat 1024141 ttcactgcca ttcagtatag aagatctcga gtgggacctg caaaagcttg tacaggaaaa 1024201 tgcggtcagt gagggagcgg tatacattca gacaacaaga ggtgtggccc cgcgaaaaca 1024261 ccagtatgaa gccggcctcg agccgcagac tactgcctat acgtttacgg tgaaaaaacc 1024321 ggagcaagag caggcatacg gagtggcggc cattacagat gaggatcttc gctggttaag 1024381 atgtgatatc aaaagtctga atttactgta taatgtcatg acgaagcaaa gggcctatga 1024441 agccggagca tttgaagcca ttttacttag ggacggcgtt gttacggagg gtacatcctc 1024501 taacgtttat gccgttatca acggcacagt gcgaacacat ccggctaatc ggctcattct 1024561 caatggaatt acacggatga atattttagg actgattgag aagaatggga tcaaactgga 1024621 tgagactcct gtcagtgaag aagagttgaa acaggcggaa gagatcttta tttcgtcaac 1024681 gacggcagaa attattccgg tcgtgacgct cgatggacaa tcgatcggaa gcgggaaacc 1024741 cggaccggtg accaaacagc ttcaggctgc ttttcaagaa agcattcaac aggctgctag 1024801 catttcataa atgaacgaag aaaagagccc gctttttaca gcggggctct ttttattttt 1024861 taacaaatcc aatcaaaatg gagatcattg gcgatatata gaggaagaac gtaaatggga 1024921 tgtagtctat gactggaaca ccaagtgcgc tcgccataaa tgcgccgctg acgccccaag 1024981 gaatcaatgg gttaattaat gttccgccgt cctctaatga tcttgtcaga aattttcgct 1025041 ggatgtttcg tttgtcatat aaagatttaa atgattgtcc cggtattaat atcgataaat 1025101 actgttcgcc cgttgccaag ttgacgccga tgcttgagca gacagttgct gcaacaagac 1025161 ggccttttga gcggatgcct ttcatgacgc cttccaatag tgcagaaatc aatccgattt 1025221 tctccatcaa tccgccgagt gcaaaagcaa tcataatgag agagacagag cccatcatgg 1025281 attgcagtcc gcctctgtta ataattttag cggctgcctc attgtcagtt tcgaaagttg 1025341 tgccattttg taaagctgtc ataaacgcct gcaggctgct gtagggtaca aaaatagcag 1025401 tcaaaattcc cgaggaaata attccggcag tcagaacggg gattactgat acccgtttca 1025461 ttgccagcaa aacgactaag agcggagaaa gaagggccca cggtgtcacg tttgcagcat 1025521 cttttattcc ggttatgacc tgctgaatat tatcggttga agcagcgtcc gctgacactg 1025581 atgaaccgag aaagtaaaac agaacgacag tgatgagcaa agctggaatg gttgtgccca 1025641 tcatatggcg aatgtgttca aagattggta tttcgcctat tccggctgca aagttggttg 1025701 tgtccgacat cggcgacatt ttatccccaa aacaagcgcc gcatatgact gcgcctgctg 1025761 tccattcaag cggaacgcca gccgcgctcg ccacgccgat cagcgctact ccgattgtgc 1025821 ttacagttgt cagacttgag ccaacaagtg tgctgatgat catacatgaa aacaaagcag 1025881 tcaacagaag gtggcttggt tcaataaagg atagggcata aactgtcata gtcggtattg 1025941 cgccgctgta catccaggcg ccgattaaga tgccgatcag cgctagaaca ataatcggct 1026001 gtacgccgtt tttgatcccg tctacaatcc ctttttcaat gctcttccag ggaaatccaa 1026061 accataaagc tgctgctgaa agcatgacaa cacttaaaaa cagcgggata tgaggttcta 1026121 catgaagcaa gaataagcaa gaaataataa tgcacaacat gaatataaat aaaccgacgg 1026181 ctaacggaaa cgtcagcttt ttttgagaat ccaaaataac accccatatt tatctttaat 1026241 gcttttgtgc ttttgggcac gaaagcatta taacagaaaa aaacgaaaat ctatgttttt 1026301 tcacaattat gaatataaaa gaagtgagca cagggcgtgc tcactttaca atcaggacgg 1026361 gtatatccga tttcgctgaa agcttttcac ttacacttcc gaatattagc tttttcagcc 1026421 tgttttggtc tctgcttccg gttacgatca tatcggcaga aatgcggttt gcatgctcga 1026481 taattgattc agccggatcg ccttctaata tatcgatatc tccatctgcc tgctgttcat 1026541 tcagcatcat tctggcttcg gcgatgactt cttccgtacg gtcttcatag atcattggct 1026601 caggtgatgt tacatccgat atcagcggat caggaacact tgtcatgcct ccgctgatat 1026661 agcttgcctc agctgcgggt ctgggcgggt cgatgacggt ctgattgtct ttcatatcat 1026721 gtgaatgggc gacggtaata gcggcattta cggttttagc aagatcaatg gctgtcagaa 1026781 gcgctttctt actattttca cttccgtcaa acgcaacaat gatacggtca gcatggaaca 1026841 tccttctcac cctttcaaag cgtcttacaa cactactacc cgaatttgag cacaattaac 1026901 cttttcctat tcaagtaatg attgacaata aaaggttttg tttatatgat gataaaaaga 1026961 tgaaatcaga atggaaggag ggtttgctat gccaaggaat ttgcgtgttt atcaaacagt 1027021 ttcatattgg cgcggcaaac cttttgttct gttttcgtga acggtttttt aggtcggacc 1027081 gcgcgctgaa aagcgctgtg cgtaacatat cggttaaaaa aggcatggag ctgacgcttc 1027141 atgccttttt tatatacaaa atctaaggaa agacaggtgt atgggatgtg aagacaaata 1027201 cagaggcgag ggcagttcgt gccaaactgg atgaaaaaag ctgcaaggaa aaaatagaag 1027261 gcggctgatg aggagatggg gatagatgtt ttcagttttg aaaaagcttg gctggttttt 1027321 taaggcgtac tggctgcgct atacgattgc gattgtcctt ttattagcag tcaatgtcat 1027381 tgaaatgttt ccgcctaagc tcttggggaa cgccatagat gatatgaaag caggggcatt 1027441 tactgcggaa gggctgctgt tttatatcgg tatctttttt gtgctgacgg cggccgtgta 1027501 tatcatgtct tatttttgga tgcatcagct gtttggcgga gcgaatctga tggagaaaat 1027561 tcttcgtacg aagctgatgg ggcatttgct gactatgtcg ccgccgtttt atgaaaaaaa 1027621 ccgaacaggc gatttaatgg cacgagggac aaatgatctt caggccgtca gtttaaccac 1027681 agggtttggc atcttgacgt tagttgattc tacgatgttt atgatgacga tctttttgac 1027741 aatggggttt ttgatcagct ggaagctgac ctttgccgcc attatcccgc ttccagtcat 1027801 ggcgattgca atcagtctat atggaagtaa aattcatgag cggtttactg aggcccaaaa 1027861 cgcgttcggg gcgctgaatg acagagtgct ggaatctgtt tcaggcgtgc gggtgattcg 1027921 cgcgtatgtt caggaaacaa acgatgttcg ccggtttaat gaaatgaccg ctgatgttta 1027981 tcagaaaaat atgaaagtgg cttttattga ttcactgttt gagccgacgg taaaactgct 1028041 tgtcggcgca agctatctga ttgggctcgg ctacggagcg tttcttgtat tccggaacga 1028101 gctgacgctt ggagagttag tgtcctttaa cgtttatctc ggcatgatga tttggccgat 1028161 gtttgcaatc ggtgaactca ttaatgtgat gcagcgcggc aatgcgtcat tagatcgggt 1028221 aaatgaaact ctttcttatg aaacggatgt gacagatcca aaacagcccg ctgatcttaa 1028281 agagcctgga gatatcgttt tcagtcatgt cagctttaca tatccaagct caacaagtga 1028341 caatcttcag gatatttcat ttacggtgcg aaaagggcag actgtcggga ttgcaggtaa 1028401 aaccgggagc ggaaaaacga caattattaa gcagcttttg cgccagtatc ctccaggtga 1028461 agggagcatt acattttcag gtgtaccgat tcagcaaatc cctcttgacc gtctccgcgg 1028521 atggatcgga tatgtgcctc aggatcattt actgttttca cggactgtaa aagaaaatat 1028581 tttatacgga aaacaggatg caactgataa agaggttcag caagccattg ccgaagcaca 1028641 ttttgaaaaa gatttgcaca tgcttccgtc cggtctggag acaatggtcg gtgaaaaagg 1028701 cgtggcactg tcaggcgggc agaaacaaag aatttcgatc gcgagagcac tcatggcgaa 1028761 tccggaaatc ttgattctgg atgattcact ttccgctgta gatgccaaaa cagaggctgc 1028821 aattatcaag aacatcagag aaaaccgcaa aggaaaaacg acatttattt tgacacaccg 1028881 attatccgcg gtagagcacg ctgacctgat ccttgtgatg gacggcggcg tcattgctga 1028941 gagaggcacg catcaagaac tgctggccaa taatgggtgg taccgggaac aatatgaaag 1029001 acagcagctg ttcactgcgg aagaaggggg agcaggggca tgaaaatagg aaaaacgtta 1029061 tggagatacg cacttcttta tcgaaaattg ctgatcacag ccgtcctttt gctaactgtt 1029121 gccgtcggtg cagaactgac tgggcccttt attggcaaaa aaatgataga cgaccatatc 1029181 ctcggcattg agaaaacatg gtatgaagct gcggaaaaag ataaaaatgc cgttcagttt 1029241 cacggcgtct catatgtcag agaggaccga ttgcaggagc ctgtttcaaa agcaaaagaa 1029301 gcgcatattt atcaagtggg aatggcgttc tattttgttg atcaggctgt cagcttcgac 1029361 gggaatagaa cggtttctga cgggaagctg acgatcacaa acggagacaa gagccgggca 1029421 tatgctgccg aaaagctgac taagcaggaa cttttccagt tctatcagcc ggaaataaag 1029481 ggaatggtgt tactgatctg cctgtatggg ggcttgcttg tgttttcggt attctttcaa 1029541 tacggacagc attatctgct gcagatgagc gccaatcgga ttattcaaaa gatgaggcag 1029601 gacgtgtttt cgcacataca gaaaatgccg attcgctatt ttgacaacct tccggccgga 1029661 aaagtcgttg cgcggattac caatgatacg gaggctatta gggatttata tgtcacagtg 1029721 ctttcaacat ttgtgacaag cggaatctat atgttcggga tattcacggc tttgtttctg 1029781 cttgatgtga agcttgcgtt tgtatgtctg gcaattgtgc cgattatctg gctgtggtcg 1029841 gtcatatacc ggagatatgc gtcatattac aaccaaaaaa tccgctcgat caacagtgac 1029901 attaacgcaa aaatgaatga gtcaattcaa ggcatgacca ttattcaggc tttccgccat 1029961 caaaaggaaa caatgagaga atttgaggaa ttaaatgaat cacattttta tttccaaaac 1030021 aggatgctga atttaaactc cttaatgtcc cataatctgg tcaatgtcat ccgcaatctt 1030081 gcgttcgtct gtctgatctg gcattttggc ggtgcgagcc tgaatgcggc ggggattgtt 1030141 tctatcggtg tgctgtacgc gtttgtcgat tatttgaacc ggttatttca gccgatcaca 1030201 ggcatcgtca atcagttttc aaagctggag cttgcaaggg tctccgccgg gcgtgttttt 1030261 gaactgcttg aagaaaagaa tacggaagaa gcgggtgaac cggcgaagga gcgcgcgctg 1030321 gggcgggttg aatttcgtga tgtgtcattt gcgtatcaag aaggtgaaga ggtattaaag 1030381 catatttcct ttactgcgca aaaaggcgaa accgtagcgc tcgtcggcca taccggatca 1030441 ggaaaaagct cgattttgaa tcttctgttt cgtttttatg atgcgcaaaa aggtgatgtc 1030501 ttaattgatg gaaaaagcat ttacaacatg tcaagacagg aactcagatc ccatatgggt 1030561 attgtgcttc aggacccgta cttattctcg ggcacaatcg gatctaacgt aagtctggat 1030621 gacgaaagaa tgactgaaga agaaataaaa aatgcactgc ggcaagtcgg tgctgagcct 1030681 cttcttaaga agcttccgaa gggcattaat gagcccgtga ttgaaaaagg cagcacgcta 1030741 tcctctggag agcggcagtt aatttctttc gctagagctt tggcgtttga tcccgcgatc 1030801 ttgattttag atgaggcaac ggcgcatatt gatacagaga cagaggccgt gatccagaag 1030861 gcgcttgatg tcgtcaaaca aggacgcacc accttcgtca tcgctcaccg gctttcaaca 1030921 atcagaaatg ctgatcagat tttggttctt gataaaggag aaattgttga gagagggaac 1030981 cacgaggaac tgatggcatt agaaggccaa tattatcaaa tgtatgaact gcaaaaggga 1031041 cagaaacatt ccattgcata acgctcaaaa acccaaaaca atcgtgtttt gggtttttgg 1031101 tttatgtagt caataagcca gtccgacacg gtttccgaca tactcacctg taacgagctc 1031161 acgatataaa aagtccgcag tatcgccgac cgaaatgctt gtgccgccct caggcaaaac 1031221 gttacgctcc gtacgataaa cgccggttgc tgttccgtcc gggaggtaag tggggcagat 1031281 gattgtccag tctaatgatg attctttaag catttcgtat acttttgcat gctccttggc 1031341 tgcgcgggtc tgctttcgtt tcgattcatt tgtttcaaac cggtattttc ccggttcata 1031401 tcgggaatct aggatccctg cggtgccgat cgtaataagc cgtttgatat gctgttcctc 1031461 cataacggag agaatgtgtg ccatagcagt tgacaaggta tcatcaccat ctgtgcctag 1031521 acagctgatc acgatttcag cattctccat tatttttttc acatcttcta agcggcgggc 1031581 gttccccatg acagttctgt cttttgaaag gggaagatca gcatgttgag atctgatcag 1031641 agcgaaaata tcaaatcttt catctgctgc agcttgtgtt aaaaaggctt gtccgacgcg 1031701 gccgctggct cctaataaag cgattttcat taaaaaacct cctcgccttt cattataaaa 1031761 ggatgttctc agtttgaaca gcgcgggaaa gaatacctgt acaaataaac agaacgatgg 1031821 gaaacatatt catgaatcat ggatacactt acgaattgaa ccagctccca attcacaatg 1031881 gtgatgaatg acaccccgat tccctccctt tttttctagg atatgtggag caggaaaaaa 1031941 gggtgacaaa ataaagagag cgcggaaacc gcgccctcta tagccatata ttgaattgtt 1032001 attgaactct gccgcccatt tgctgctgag cgaaagatac taaacgtttt gtgatttctc 1032061 ctccgacaga accgttagcg cgagaagttg tgtccgctcc aaggttaacg ccgaattcag 1032121 aagcgatttc aagtttcatt tgatcgatag cctgagctgc gccaggaact agtaagtcat 1032181 ttgaagagtt ttggttagcc atgtgtaaaa tctccttttt atttagtatg gttgggttaa 1032241 ctggagttgc accaatctgt gaacccttct cgggtgtcac tgccgcctcg gcgtaaccca 1032301 atgctttgcc ggcttgttac tacgtattat gttaaaatgg ccggaaaatc atgcggagaa 1032361 ttgtgtggta aatcttgaga aataaaaaaa gcttagccgt ttaggctaag ctagtcataa 1032421 atatgaaaaa gcatcagttc atgtatctcg tttgtaagag caggctcgtc agcgcgggcg 1032481 ggaaacaagt ctccccattc aatctcaccg ctcttatgat agatgccttc ataatgggtc 1032541 cctttataat aaaatgaaat tttccatccg ggcagctttt cttttgggaa caaaggtttc 1032601 cagctgaaat gagaaatcat tacggccacg ctccttacat ttggtatcaa ttgacctaaa 1032661 taaaaacggc ttatgttcat tgtatcattg tttcagaaca tcattgaaga ggcctaaata 1032721 tgcagtttgt cccagctttg gataaagata agcccgcttt attaaaaaag cggacaggtt 1032781 acgaaggcca caatgcttcc ggagatgtga ttgccttctc agataaatat gacgcgtatt 1032841 caaaacttct tcgttttgta agagaatcaa catgatgcaa atttggatga gaaaaaatgc 1032901 ttcggcccgg gcgcgaattc gcttcaaaca tccatacttt accgttctga tcaatgccaa 1032961 aatcgaaacc aatctccccg ataaatccct cgatatgatc atgaaggaca tggcttgcag 1033021 tcagtgccgc tgcagaaagc tttttaatga cctcaactct ttcagcggga tcatcgtata 1033081 cttccgcaag tgtctttaca gtgccgccgt tagaaagatg tgttgtaatg ctgttctttc 1033141 cggaaatttt tacggcgatt gctgtcactg tccattttcc ttttctgttt ttattggtat 1033201 ggacacggaa atccgctggt ttgccttgaa attcgatgag atcaacacct tgctgaatga 1033261 gaaagtcgga cgggttgtga tgtttttgaa attctgcaag gaatgaggcg gcatcggaat 1033321 aatcaattga tgtaaaagtt ttggcgtcat tcgtatgctt taccgtcagg ccgccatctg 1033381 ttcttgtcag ctgataaatg ccggtgccga gtgctccatt tgccggtttg atatagactt 1033441 ttttgtatgc gccacagagc tcatctatca gctccacaga cggtgtcagc tcggatctag 1033501 gcaaaaaggg tgccgttctt ggatcttttt cgagcaattg atgaacgttc catttattga 1033561 aaaacgtttt attaaaccat gggatctgat attcatcgat cagcctcttt tttgtatgtt 1033621 gcaagagaag tgaatcttca atttttcggt tcggcaaacg gtcataaacg acgttcggca 1033681 atggaacgat ttttttctcc cagccgtttt ccctgtaaag gaggccttca atcgtgcctt 1033741 cctcccaatt gatttggtgc gcgccaaaaa cgaagcagta gcccccggct tgctcgtgta 1033801 acgtgacaag tttagaaaaa aagagggaac gatccttaaa tgggcgttca agagatacag 1033861 taaaccctgc cgtaaagatg ccgactaacg gcccgatatg cactgtatga tcatgaatca 1033921 gtatatctgc cctgcttcgg tggggaagca aaagctcatg aaacagattt tcagagagaa 1033981 gcacggtttg ttccagatgc cgtctgtaag caacgtggca tctgacaacc ttcgttccga 1034041 atgcggcatg caaaagtccg tcttgcttca gcgaagaggg cagaaacagg gtgttttcac 1034101 tggttttgtc tatgccgatc aaaaaccgtt taggattcac gcggaagaac tcctttctgg 1034161 ctttgctcag aaaacagata ttggcagcgt tttaggggac aagtgtacag ctgttctttt 1034221 tgctcgggag agacacgcag gattgacttc ctgcctggtt tggaattgat atctaaaatc 1034281 caaattctcc cgtcctttgc aagacatata tcaagaccga gttcaaacaa cggcccatag 1034341 cgctcgtcaa gataatacgg aaccgattgg gtaattgaaa acacatcatc tagtaaaacc 1034401 acttgctgtt ttttcggtat atcttcaaac caggagtcaa atgtcagcgc atcagatccg 1034461 cctgacaaat tggccagcag cccgtgtttg tatccgcgtc ttactgcctt tccgactgta 1034521 ttccattcac ctgcttcgtt tttttccata aacagacgaa tatcacaagg gtattgttcc 1034581 ttatcttgaa tgtttaagta aggctgaagc aaatattgat gctgaagcac ttttttgcac 1034641 catgttttaa aagaagtctg gttggaaaac gtttttgtct gcttatcctt tccgatgtga 1034701 taagtagcag tgatgttttt cttgcccagc ttcaaaagaa tcacgcctct gcctcccgcg 1034761 ccgaatgccg gtttaaggat gcaggctttt tctttggata aaaaggagtg aatttgttcg 1034821 tagcggctca cctttatcgt ttcgggaata tagggattga ttacagagtg ctgctgcaaa 1034881 tcgtgaagga cggtccactt atcgggaaga ccccgcccga taaattccgt tttcggatat 1034941 tttttgagcc actcaacgat tggttttgct ttttgggaat gtgaatcctt gccgtaaaaa 1035001 cagcgatcat aaatataatc tggaatcgcc atttcagttt cgttccatgt gctgctggcc 1035061 gaatgataga ccgatgcttt gacacgcaaa gtgtcaggtg aaatatcaaa tggtgtaaac 1035121 cggatgaaac gtatgccgaa ttcgggtgct cttttggcca gttctgcgga ataatccgct 1035181 tcatgctggc gggataagga cataaaaccg agtgttatca tggtgagact ccccctttta 1035241 ttcaaaagct gccggcgggt gtccgcagct ttacactaaa tacatgtaag acgaacgcag 1035301 ctgacggtat tctactttac agaatacgat tctccacctt gccctattcc aaaagaacaa 1035361 gctgattttc taagaacagg aatttgtctc ctcgtttgct aagtgattgc atgagcctct 1035421 ataatacgta taggtacata atctatatga aaaaagctga agcacagatg gaggaagatg 1035481 aataggaatg ggtattgcag gaacctttat ttttatgatc gtgatcggcg ctgccattgg 1035541 agcggtgacc aatcatttag caattcaaat gctgtttagg ccgtataaag cgtactattt 1035601 gtttgggaaa cgagttcctt ttacgcccgg gctgattcca agacggcgag atgaacttgc 1035661 aaaacaaatg ggactgatgg tagtcaatca tctcttaacc cctgaaggca ttaaaaagcg 1035721 gctcgtctct gatgcagcca aaacgcaggc tcttcgagtg ggggaacagc tgattcaaaa 1035781 gctgtcactt tctgaagtga cagtaaaaga agcgcttgaa aaagccggga tgaagcgccc 1035841 cgaaaaagct gctgatgcat ggatcagcag ctggaccgat gataagctgc atgagctttt 1035901 ccgccaatac ggggaccaat cgttaaaaga gctggtgcct atagaggtgc aggaaaagct 1035961 tgaggaaaaa attccgatga tttcaggata tatattgtca cggagtgtcc gttattttga 1036021 aagtgatgaa ggaaaaatcc gtcttggcaa tatgattgat gactttttaa aagagcgcgg 1036081 catgcttgga agcatggtgc aattgtttct tggcaattca agccttgcgg atcgcgtgct 1036141 gccggagctg ctgaaattct tgcgcaatga ggaaacaaat aaattgcttt ctgatctctt 1036201 aaaaaacgaa tggggcaagc tgagggagta tacgtttaat gaagcagatg aaaaatggaa 1036261 tgcaaaggcg ctcattttca gtttgaaacg aagagtgctg caagcatttt cgactgcccc 1036321 tttcttcaac aatacgattg gcacgcttac cgtccgctat gaatctgagc tgacccagca 1036381 aatgctgccg gcactattag acaaattgct tgaaggtatt tcgtccaacc ttgaaagtgt 1036441 cttaaaacgg ttgcgtcttg aggaaatcgt caaggagcag gtggatcagt tcccggtgga 1036501 gcgtcttgaa gaaatggtgc tgtccatttc aaaaaaagaa tttaaaatga ttacctattt 1036561 ggggggcctt ctcggcggaa ttataggcgc gattcaagca ttgtttgtca tcctttttta 1036621 agaagaaatg gtttttgatt aatgaaagga gctccatagt ctgttatagt ggagtggtat 1036681 gtcaaacggc aatgatgaaa ggagctattt acaatggctg ttaattttta tgatgtagcg 1036741 tatgatctgg aaaatgcatt acgcgggagc gaagaattca cccgtttaaa aaacctttac 1036801 gacgaagtta acgcagatga atcagcgaag cgcatgttcg aaaacttccg tgatgtacag 1036861 cttagactcc agcaaaaaca aatggcagga gaagagatta cacaagaaga agtgacgcag 1036921 gctcaaaaaa cagttgcgct tgtacagcag cacgaaaaaa tttctcagct gatggaagcg 1036981 gagcagcgca tgagcatgct gattggtgaa ttgaacaaaa tcattatgaa gcctttagaa 1037041 gagctttacg gcagtgttga aggctaataa gcaaaatccc ttcttggata agaagggatt 1037101 ttttattcac tcagcaaact tggaaatcca atgaatcttt tacctctcca ttgatgatga 1037161 ctgataatgt atgaattcct ttgtaatgct ttctggtggt taaatcctta aaggattgga 1037221 ttcttgtgta tgacttcgtt tcgttttttc gtatatttgt ttctgttatt ttaaatactt 1037281 tctgatgacg ctggcctctt gcttttacaa aatcaattgc gtactcaatt cttacttttt 1037341 gatccctgtc tgaatgaata tagaaagaaa attcaaggct ttcgccaata actatacgtt 1037401 tgggctggca tgttaaatca tgtagttgta tcgaatcagc attttcataa ccaaaaagcg 1037461 ctaaggcctg tttatcaccc ttttttaata aggtccgata ggcgtgtttg ataatccagt 1037521 ctgtatgggg atgtgttccg taccattgat ctgcgacttt tctcagtaaa tgaggatgcg 1037581 tttttgatat atcattaagg ttgttggcca cgctttttct tacatataaa gactcgtcct 1037641 gcatcagctt ctcaaggatc ggcaatacgg gggaagggtc cgatttcaaa gccggtatcg 1037701 attttcccca tggcaggcgg ggcctgctgc cttcgctcgc aagtcttctc acgtgttcat 1037761 ttttatgctc agaccatgca agcaattgtg caatcatctt ttcttgatct aacagcaaaa 1037821 aaggccttac agcaaattct gaggtcgaat attgcgtaaa ggattccaat gcctttattg 1037881 attcttccca atgcgctaac ccgtactgtt ccacataatc tggaaataaa attccgctga 1037941 gtcctttaaa atgaggggct gtatcccgta aaattgtgag cgcttcaacg tattgttttg 1038001 gcaaagtttc gtataaagaa actgtcacgc ggcgcatccg ctcttttaaa gtgagttcag 1038061 gccagtcctc cagccgtaat gtatccaaga atctgttttt gttaaaatca ggataggatg 1038121 accttacatg atggatcaac tgagatatca gttcttcatt atatatttct tttaaatcag 1038181 ccatataaac accgcttttt cgtttattat ttatattgta tgggaatgta cgttctggat 1038241 caagtgtata gtcctaaaaa ttaacaactg atcctaccac ggatatacaa aagttggtta 1038301 ctttttttag ttaaaaaaac ccttgtcatc ggaaaggaaa actgagataa taacattgaa 1038361 agcgcctaca cttacctatt tcaaatggat acggtcgcat atcatgccgt tatatagagg 1038421 ggataagcaa cagagagtaa gtgttcggag cgcatcattg gtcaaacaag gggttcctga 1038481 tacatgattt ttcgtaaatc gaaataacga tattagggag aatggctgct tcgatcgtat 1038541 cctatcaaca agccatacat aaagtctgct gagccaggct ttttttgctt taagaaaagg 1038601 ttgttctaaa cacagagaca gggtcatatc ctatacacaa gtacagtcat caaggagggg 1038661 gacatctctg tgtcaaaaca attgcttgcc ttaaatatag atggagcgct gcttcggtcg 1038721 aacgggaaga ttcatcaggc aacgaaagac gcgattgaat atgtaaagaa aaaagggatt 1038781 tacgtcacac ttgtgaccaa ccgtcatttt cgctcagcac agaaaatagc gaaatcgcta 1038841 aagcttgatg ccaagctgat cacccatagc ggggcatata tcgctgagaa aattgacgcc 1038901 ccgttttttg aaaaaagaat ttctgatgat cataccttta acattgttca agtgctggag 1038961 agctatcaat gcaatattcg gcttcttcac gaaaagtatt ccatcggaaa caagaaaaag 1039021 gtgaattcga atttattagg gaaagcactc attcatccgt ctgacccgat cttttatcca 1039081 gtccagttcg ttgaatcatt aagcgatctc ctcatggatg agccggtgag tgcacccgtc 1039141 atcgaggtgt acacggagca cgacattcag catgacatta cagaaacgat tacaaaagcc 1039201 ttccctgcgg tggacgtgat tcgcgtaaac gatgagaaac tgaatatcgt cccgaagggt 1039261 gtctcgaagg aagcgggttt ggccctcgtc gcttcagagc tgggcctgag tatggatgat 1039321 gtcgtggcca ttgggcatca gtatgacgat ctgccgatga tcgaacttgc cggtcttggg 1039381 gtagcgatgg ggaatgccgt tccggaaatt aagagaaagg cagattgggt tacaaggtcc 1039441 aatgacgagc aaggtgtcgc ttatatgatg aaggaatatt tccgaatgca gcagcgaaaa 1039501 ggatttcttg ataagttcca catgaaacgt gtgtaaaaaa gccgctcgcg ccctgacagg 1039561 tgcggcggct tttttgccgg attgatttta gcagtttatt tctgtacact aaagaaagtt 1039621 ttgaatctga taaattaggt gatgaagttg caaattaaaa tagaaggcat acatgatgac 1039681 cgcctgcatc ggcctctgca aaatattgca aatttgtttt atgaagagtg cgagcttgcg 1039741 tatggcggag aggagcccgc agattttgtc atttctttag cgttgtcaca aacggatgag 1039801 catgtgacgg tttctggaga agtgaagggt actggcataa aggaacagca tacaaaattc 1039861 ttttctccag acatgactga aaaagaagct tttaagcaag tgaaaaacac aatttcttat 1039921 gtgtatctca atcttcttca ggcgcatacg ggcattacgc agaagtgggg aatcctcaca 1039981 ggaatccggc ccacaaagct gcttcataaa aaactgcaaa gcggaatgtc caaggagcaa 1040041 gcgcatgctg agttgaaaaa agactattta attcatgatg aaaaaatcat gctaatgcag 1040101 gaaattgttg accgtcagct ggcggcagtg ccggatttgt accgagtaaa ggatgaagtc 1040161 agcatttata tcggcattcc gttctgcccg acaaaatgcg cgtattgcac attccctgcg 1040221 tacgctatcc aaggacaggc gggcagagtc ggctcattcc tatggggact gcattacgaa 1040281 atgcagaaaa tcggtgaatg gctgaaggag catgatgtta aggttacaac catttacttt 1040341 ggcggcggga cgccgacaag cattacagcg gaggagatgg atctgctgta tgaagaaatg 1040401 gtccgctcct tcccggatgt gaaaaacatt cgtgagatta cggtggaggc cggtcgtcct 1040461 gacacgatta cagaagaaaa actcgccgtt ttaaacaaat atgacattga tcggatcagc 1040521 atcaatccgc aatcctacga aaacgaaacg ctaaaggcga tcgggcggca ccatacggtt 1040581 gaagagacca ttgagaaata tcatctgtca cgccagcacg gcatgaataa tattaacatg 1040641 gacttgatta ttggtttgcc tggggaaggc gtgaaggagt tcaggcacag tctttcagaa 1040701 acagaaaaac tgatgccgga atcccttacc gttcatactc tttcatttaa acgggcgtca 1040761 gaaatgacga gaaacaagca taagtacaaa gttgccggca gggaagaggt ttctcaaatg 1040821 atggaagacg cggtagcctg gacgaaagag catgggtacg tgccttatta tttataccgc 1040881 cagaaaaaca ttcttggaaa ccttgaaaac gtcggatact ctttgccggg acaagaaagc 1040941 atctacaaca ttatgattat ggaagaggtg cagacgatta ttggcatcgg ctgcggcgct 1041001 gctagtaaat ttattgatcg ggatacaggg aaaattacgc attttgcgaa tccgaaagat 1041061 ccgaaatcgt acaatgagcg cttcgagcac tacacggacg aaaaaatcaa atatttagag 1041121 cagatttttg aaaaaacgac aaagcagcac tgattacagt gctgcttttt ttatccctgt 1041181 ttttttgcgg gctgaacctc aggcttccat ttaaatacct tgttcagcaa gcggtaaatt 1041241 cgttttgatt cctttgtgac aagcggtccc aaaatcgcca gaatgaggac atataatgcg 1041301 gcaaacggct ttaatgtggc cgacagtccg ccggctatcc cgagattcgc aacgataatc 1041361 gaaaattctc cccgcgatac gatcgtcagc ccgatattcg atgaagcctt atgagaaagc 1041421 cctgcgcgtc gtcctgccac cattccggcg ataaaatttc ccagaatggt caaaatcact 1041481 gcacccaacg caagccaaac cgcttcacca agcgaaaacg gatcgatgct gaggccgaag 1041541 ctgaaaaaga acatcgcacc gaagaagtcg cgaaacggaa caacgaggtg ttcaatccta 1041601 tcggaatgct ctgtttctga aaagaccaaa ccgagcagca gcgcgccgat tgcttctgct 1041661 acatgaatcg tctctgaaaa accggcgata aaaaagagtg ctgcgaaaat gacgataata 1041721 aacacttcgt ttgagcgaat gtccaacagt ttgttcaaca gcggcgggag ttttcttgct 1041781 gcgataaaaa acagcagcat ataaccgaag gcgatcaaaa tggacaagag tgcactccct 1041841 acggatgtcg catcacctag tataaggccg gaaacaacgg acagatatac ggcaaggaaa 1041901 atatcttcaa acatgatgat gccgagaatc aattcggttt ccgggttggc ggttcttttt 1041961 aaatcaacga gcacttttgc gacaatcgca cttgacgaga ttgtgatgac gcctgcgagg 1042021 atgaggactt ccagaaagga aaatccggtg ataaacccgt aaagcagtcc gaggctgaag 1042081 ttaatcaaaa tataaatcgt cccgccgacc gcgattgatt ttcctgattt gattaacttc 1042141 ccgacagaga attcgagtcc gagatagaag aggaggaaca gtacgcccat tcgcccgaaa 1042201 aactcgatga tttcactgct ttgaataaat gttagatcaa taatccccat tttcggcgcg 1042261 tgcggtccaa caagcattcc cagcacaatc agaaacggaa taatcgaaaa tttaatttta 1042321 ttggcgatca cactggcgat tgccacaagc acaagtgcag ttccgacttc aaatacaaga 1042381 tggtccatcg gggctcacac gccctctcca gaaagaaaat cgtgaatcag tttcttcaga 1042441 tgctttctct cacctgagag gacaagggtg tcattttctt caataatcga atccgctccg 1042501 ggatttagga gcttttcctg gttgtgtttg ataatcgcaa taacagtgac atcgtaattc 1042561 tggcgaacat caagctcacc gagtgtgcgt ccgatcgatt tggcgccttt ttcgacctta 1042621 aaccattcaa taataagatc gctgaaggcc atttcgatgg actccagagc ttgcggttta 1042681 tagaccatgc ccccgagaat agctgcaatt tgccttgctt cagaatcatc caatgaaata 1042741 tttgaaagaa gctcatccgg gtcccggtca ttaaaccggt aaatttccct tcttccgtca 1042801 tcatgaatga taatcgtcat tttttcgtgg cttcttgttt cgatttcaaa ctttttgccg 1042861 atgcccggca gatcgttttc tttaatattc aatgaaaatc cctccgaatg tagtgttggc 1042921 agtatggggt gagttacaaa taaaacttga gcaaattata ttcggaggta attagactgg 1042981 tatttgacag ggacggccaa agccttttcc agcctgttta tcagcggttc gtcaagtggt 1043041 ttgacagaga gctgcctgac agactgcgcc agcgggctgt actctttgat cagctcagcc 1043101 gggtgcatgc tgcccggcga tggcgttttt gccgattgtg tttcctgcgg atatgaagac 1043161 ataggcacat agctgtcagt gcttgcttca aactgggaag gcagaaccac gtccgaaggg 1043221 ggaaagtaca ccataaataa acttaacaga aaactgatca gcaatttatc catgttcctt 1043281 tcctcccttc tcatcaagat atcccttctt tttcactata taaaacttta tgtttccatt 1043341 caaacaatat gcatttttca gtatctattg accttgaaaa ataaaaaggt ttatttgggg 1043401 atggcgggga atgtatagga gaaagaaaaa agtaagcgca tacatggagg tgcttttaat 1043461 ggagtttgtt caatatgcat gtaatggggc cgttgcagag attatcctga atcggcctga 1043521 tgcccatcac gccctgaatg aacagatgct gtctgaattg aaggaggcag tcgaaatggc 1043581 ggctgcaagc gaggcgctca tcgttctcct gagaggaagc gggaaaggct tttcggccgg 1043641 cggtgatatc aggatgatga cgtcagagca tgaccctgac caatttaaac ggctgatgga 1043701 tacgattgag gctgtcaccc tgaatttata tcagatgaag aaagtgacaa ttgcagccat 1043761 tcatggtgct gctgcgggac tgggcctgag tttggcgctt tgtgcggaca ttgtgctcgc 1043821 tgaaaaaaac gccgttctcg cgatgaattt tatcggcatt gggcttgttc cggacggcgg 1043881 aggacattat ttgctgaaga aaagaatcgg tgaagcaaaa gcgaaaaaac tgatttggag 1043941 cggaaaaaaa ctatctgcct cggaagctgc cgatatgggg cttcttgatg ggacatttgc 1044001 cggagaccct gccgaaggcg caagacccat tatcgaaacc ctgttggcct cccctctttt 1044061 ggcgatgatc gaaacgaaag gtatttttca aagcctccaa attgaagaac tgaaaaaagt 1044121 gctatccctt gagcgcagcg cccaagagag aatgagaagg accaaggatc accaagaagg 1044181 aatccgtgcc tttttagaaa aacgggagcc gaagtttcaa gcgtaacaga tcagccggaa 1044241 agctgatcat ctgtgaaaca aaatcagctt tccggctgca ttgactaaac gatgagtatg 1044301 actatgaagc tctttttctt ttaagagggc ttcaccatgc gtttttgccg cttcttcatg 1044361 ttctgcctcg aattgctcgt ttaccagcgt gttccccgaa ggatcaaata cggtaaggaa 1044421 ataatcagcc atcaggtttc tcctccattt taaggtttat cagtctttct tcatttatat 1044481 tctaaaaagg aaatcaaaat cctttattat gctttatcca aaattagtat ataatgggtc 1044541 agggaaggag gagattcagt gcttacaatt gatcacgtaa cgaagacatt tggagattat 1044601 aaagccgttg acggattgga cttagatatt ccggaacagc aaatgttcgg tctattaggc 1044661 gcaaacggag cgggaaaaac aacaacgttt cgcatgatcc taggattatt aagcattacg 1044721 gagggctcaa tcagctggaa gggccgtcct gtgaattatc atatcagcaa caaaatcggt 1044781 tatttgccgg aagagcgggg cctttatccg aaaatgaagg taagggatca gctcgtctat 1044841 cttgccagat taaaagggat ggagaagcga gaggctgtaa aagagctcgg gacatggctt 1044901 gaacgcttca atattacaga ttacgagaat aagaaggtgg aagagctttc gaaggggaat 1044961 cagcagaaaa tccaattcat ttcggcagtt ttgcataagc cggagctcct gattcttgat 1045021 gaaccattca gcggcttgga ccctgtcaat gttgagctgc taaaagaggc cgtgatctcg 1045081 ctgaaaaaca gcggtgtttc tattttattt tcaagccatc ggatggaaca tgtggaggag 1045141 ctttgtgaga acctttgcat attgcagaaa ggaaaaccgg ttgtacaagg caagctgaag 1045201 gagatcaagc gttctttcgg taaaaagaat gttaccattc actccgatga cgatctgcgc 1045261 tttttgcagt cccatgaagg cattcttcaa tggaaggaaa cggcagacgg cgtcaagctg 1045321 cagattgcca atgaagacat ttctcaagag atttttgcga tgctccaagg aaaagggttt 1045381 atcagaaagt ttgagcttga agagccgtca ctgcatgata tttttataga aaaggtgggg 1045441 gccgtctatg aataaatttt ggatcatgct ttctcataca tacaaaaata agattatggc 1045501 aaaatccttt attatttcga ctgtcatcac ggtgctgctt gttttagttg taacgaatct 1045561 ggagtcgatc atttctttgt ttcaaggtga cgatgcgaaa gaaaaaatcg ccgttgttga 1045621 tgaaacaaac gaattatatc cggttttttc taagcagctg aaagcggtgg atacagacgg 1045681 cgatcttgat gtgaagctgt cgaagcaatc ggaggatgag gtcacaaagc aagtcaaaga 1045741 tgaatcactc gatggcatgc tcatcatcaa acgagatgaa aaagggacca tttcaggaac 1045801 atataaagcg ttaacgattt ctgatgaaag cacgtatcaa acactgcagc aggcgctgac 1045861 gcaaaccaaa acagctgtcg gaacagcgga gctcggcgtg tcgcaggaaa cgattagcag 1045921 cctttatgcg cctgttactg tggggcagaa ggcgctgaaa gaaggggcaa agtctgagga 1045981 agagcttggc cagacggtag ggcttgttta cattatgctg ttcgtcattt atttctcggt 1046041 gattatgtat gccagcatga tagcgatgga ggtcgcaacc gaaaaatctt cgcgagttat 1046101 ggaaatcctg atctcaagta tgccgccgat ccagcaaatg tttgcaaagc tgcttggtat 1046161 cgggcttgtc gggatcacac agcttgctat tattatagga gccggctctc tgtcgcttaa 1046221 gctgaaccaa aagagcgaaa cggcttcatc tgtcggcgga ttccttaatt tgaccgacgt 1046281 atctgcaacc actgtcatct atgctgtcat tttctttttg ctcggatact ttttgtacgc 1046341 gacacttgcc gcgtttctcg gcagtgtcgt cagcagaata gaggacgtgc agcaaacgat 1046401 cacgccgatg acgcttttgg ttgtcgccgg ttttatgatc gcgatgttcg gtttgaatgc 1046461 gcctgacgca ggatttatta cggtaacttc gtttattccg ttctttacgc caatgattat 1046521 gttcctgcgc gtcggcatgc ttgatattcc gttctggcag gcggctgtcg gaatcggaat 1046581 cacactgctc accattgtca tactggccgt tatcggcgcc agaatttata aaggcggtgt 1046641 attaatttac ggcaattcaa gcgcgttcaa agcgatcaaa caagcgctac gtttagcgaa 1046701 aaactgattg gaaaacagcc tggggattct caggctgttt ctttattgac agaacgtgca 1046761 ttcgcaagaa ttcggtgcta aaataagggt acttcatcct ggaaaggagc agaatgttga 1046821 ctgatctaac ctttattcat gcggcagatc ttcatcttga cagcccgttt tacgggatat 1046881 cgcatctgcc ggagccgatt tttgcccgga ttaaagaaag cacgtttgca agcgtgagac 1046941 atatgataga cgccgcagtg agagagcacg ttgatttcat tttgcttgcg ggagatctgt 1047001 ttgatgaagc caatcgaagc ttaaaggctc agctcttttt gaaaaaacag tttgaaagac 1047061 tcagagagtg cggaatttcg gtatacgtca tctttgggaa tcacgatcat cttggcgggg 1047121 agtggacgcc gattgaatgg cctgagaatg tccatatttt ttcgtccgct gttccagaag 1047181 aaaaatcgtt ttttaaagaa ggcaggcgca tagcaagcat ttacggcttc agctatcaag 1047241 ccagagcatt gatggaaaac caagccgccc gctatcggag atcaactgac gcaccgtttc 1047301 atatcggcat gctccacggc acgctgtcag gatctgaagg acacgatccg tattgcccgt 1047361 ttacacatga cgacctcgtg aaaagcggga tggattattg ggcgcttggc catatacata 1047421 aacgccaggt tctatctgcc gagcatccgg cagtcattta cccgggaaac acgcaagcac 1047481 gccatataaa ggagacggga gataaaggct attatctcgt tcatgtgaca aacggagata 1047541 tatcttatga atttcagaga gcgcatgatg tcctgtggga aaaagcggcg gttgatgtga 1047601 cggaggcaaa gaatatgaca gccctcttcc aaatggtgga ggacacgttt tcgaagctgc 1047661 ggaaaaaggg gagccctgtt tgtgtaaggc ttgttttaca agggacggcg ccggaatggc 1047721 tgctggaggc gccaaaaggc accttggatg agtttcttga agctcttcag gaacaagaag 1047781 cggaagagga acgtttcgtt tggcctctta gattggacga tgagacagaa aacgaagcaa 1047841 acctaacaaa ccttgatcct ttttttggcg gtttatttga agacattgat cgcagcgatc 1047901 tgtcagacgt gctggaaggg cttgagcggc atccagtgta tagaaggcac gcggaccggt 1047961 ttagccaaga ggaggtaaag gaaataaaag agcaggcaca gataatattg aaaagacagc 1048021 ttaaggtgct tgatacatga ggcggtgaca gctttgcgaa ttatatcttt acatatctac 1048081 caatacggaa aattttccaa tcggaccttt gacttttccg cctctcctgt ccaagtcatc 1048141 tacggattaa atgaggcagg aaaaacgacg atgatgtcat tcattgaaag catgctgttc 1048201 ggttttccga aaacgaaaaa gtatgaaccg aaaacaggcg gtgtctacgg cggtgttctt 1048261 gaagctgaac atcctgagta tggggtgctg aagatcgaac ggacgaaagg gactgccgaa 1048321 aaactaagcg tgtacacaga aaagggcgaa gtaaagcagg gagatgtttt aaagcagctg 1048381 ttccagggca cagacaggtc gttgtacaaa gccatatatt cgttcgacgt attcgggctg 1048441 caggaaattc acgcctttaa tcgggacaag ataggggaat ttttgctctt ttccagcttg 1048501 tttggtgctg aagccgtatc aaagcttgat tcaaggctga cgaaggaaag cgaaaggctc 1048561 tataaaccaa atgggcgaaa ccctcaattg aatcaggagc tggaaacgct taagcagctg 1048621 gcagttaagc taaaacaggc tgaagcagag gaagcgggct atcatcagct tctcgaggaa 1048681 aaacgaacgc ttgaagcccg ccttgcagcc gcggaaaccg aattgaaaga gacggcggga 1048741 catatccgaa tgattgaggg agcgattgag cgaaagccgc tgctaaatga aaaagcgaca 1048801 ctcgaacagg tgattgcaga atttccggaa cacgcaggac aatttcctgc tgacggactg 1048861 catcagctgg aaaaatatga atcccatctt cacccgaaat cagcacagct tgaggcgctt 1048921 cgggtgaaga tggcggagtt ggacaaacag aggcaaaagc ttatccccga taaagaacta 1048981 ttggcgaaag aaacgctgat acaagagctt tcggcagcgt ttcatatgta ccaatcctgg 1049041 ggagaacagc tggcagccat tcaggcacag ctgcgccaga cgtctgcgca gacagcggca 1049101 gggctggaac agctcaataa aacggatgaa aatgagctcc tgaatatgaa cacctcatat 1049161 gattatgaat ggcagcttca gcaagcggtg cagcaatatg tacaggcaag agacagaaaa 1049221 cggcagcttg acgagacgtt tgaacttgcc cggcaagagc tggaagacgc ggaaaaggcc 1049281 gttcgtgccg cttcgtccgc gattcttgaa aacagccaaa gaaaagataa agaagcagct 1049341 cttagagcat atgatgaaac acaggggcag caccaagagc aagcgaagct cagagaacag 1049401 ctaacgtttt ttgaaagaca gcaggctaaa cagaaaaaga ctgtcattgc agctggtatg 1049461 ttgttcatcg ttctcttttc tctgctgcag caatggattc ccgccataag tttcggcgct 1049521 gcacttattg tgtattggct tgtttcagga aagtcgtctt ctcgaaacag ccgagagaca 1049581 agacagccca tgacggatat ttcaccagca gaagctgaaa tgcttagaga agcgttatgg 1049641 gaggatgacc gcaataagca gcaccttctc acacagcgtg cagcgctcca gcaaaaagag 1049701 gcggcgtatg aaagggtcat ccagcagttt gaacagtggg aagccgaaat ggcgccgtcc 1049761 tttacacagg ttgagcgttt tatgaatgag ctcggattta aggaagatcc atcatttttg 1049821 cttgatgcat acagcttaat gaaggatgtt aaaaaagaag tgaagaaaaa gcatgagctg 1049881 accatagaag caggcaggct gaaaaagcac cggagaacat tcgaagaacg cgtcagtatg 1049941 cttcttcccg tgaatcagag tcaggatatc tccatttcgg acgcccttca cacattgcgg 1050001 aaaaacattg aacgtgaaaa agaaattgag aagcaaaaaa aggaaattga aacagatatt 1050061 cattatacaa aggaacagat gcttgaactt gagcaagaaa tacagtattt ccacgcacag 1050121 attgaacagt tatttgccgc ggctgctgca aaagacagag atgcgttttt tgccatagcc 1050181 gccatcagca ggcaattgaa ggatacggag aacaagcttc atcacgtaaa cgcacagctt 1050241 caaggcgggt acccggagga acttgaactg gcggattcca atacgctttc tgaattgaaa 1050301 gataagcaat ttgttgagaa tgaaagaaaa gagcggctga ctgaggagat cgagcagctc 1050361 cgcagccaaa tcgcactgct ctcagtcaaa caggaacaat tagaggcttc gggaatggtc 1050421 tcagacctca agcttcaaac cgaaatgcaa aaagaacgtg tgaaagaaac ggctaaaaaa 1050481 tgggcctcca tacaaatggt caaacaggtg atcagaaaca aattggagcg gcataaaaaa 1050541 atcgagcttc cgcgccttct ggagacggca ggagaatttt tccgtcctct gactgacgga 1050601 aactaccaaa ccatttattt ttccgaaacg gatgattcga tcatggttat gcatcgcgat 1050661 ggcactgtct atcatgcgga agagctgtca caagggacgt gtgaacagct gtatacagcg 1050721 atccgctttg ctttggccgt tacgcgccag ggtgagtcaa agcttccgtt ccagcttgac 1050781 gacagttttg ttcattttga tcaggaaagg ctgaaacgtg tattacatgt tctgtatgat 1050841 ttatctgaag gcggtaggca gattttgtat tttacatgcc atgagcacgt aaaagatgca 1050901 tttcatagca gccaaatcat ccatttggtg tcataaaaga ggttctatag ctgaaaatcg 1050961 gtatgtgata tactggtatt atgtaagata cggagggagc tttaatagaa tggctaaagg 1051021 gattatgcta catgaggttg gcgaacaggt ggaccagtat ctattgatta aatcctcgac 1051081 gaaagggatt gcaagcaatg gaaaaccgtt tctgacgctg atgctgcaag accagtcagg 1051141 cgatattgaa gcgaagctgt gggatgccaa gcaaagtgat gaagtgacct atgcgccgca 1051201 gacgattgtc aaggtcgtcg gcgatgttca ccattatcgc ggacgcaccc agctgaagct 1051261 aagaaatatc agaccggtaa gcgagcaaga aaacgtcaat attgatgatt ttttagaaac 1051321 cgcgccgatt ccgaaaaatg aaatgatgga taccatcact caatatatat ttgaaatgaa 1051381 aaatccgaat atccagcgaa tcacaaggtt tttggttaaa aaacacgaag ctgagtttat 1051441 ggattatccg gcggctacga aaaaccacca tgagtttgtc tcaggtttgg cgtatcatgt 1051501 tgtctctatg ctgaacctgg cgaaagcaat agcagattta tatccttctc ttgatcgtga 1051561 tctgctttac gccggtgtta tcctgcatga tcttggaaaa gtgaaggagc tgtccggccc 1051621 tgtttccact tcatatacgg ttgaaggcaa tttgctcggc catatttcca tcatggtgac 1051681 agagctttca aaagcggctg aggagcttca aatcgattct gaagaggtgt taattcttca 1051741 gcatttgatt ttgagtcacc acggcaaagc agaatggggc agcccgaaac cgcctatggt 1051801 gaaagaagcg gaaattcttc actatataga caatctggat gcaaaaatga atatgatgga 1051861 cagagcgctt gagcgcgtga agccgggcga gtatactgaa cgtgtatttg cactggaaaa 1051921 ccgttccttt tataaaccga catttcataa ataacttaaa aaggactgat gctgacatat 1051981 tcagctcagt cctttttgat gcgtctttcc cgcacataac tcgtctcatt cccgcatatg 1052041 gttaagaata aagaatctat gcaaaggggg aggagcccgt gttatttttt ccgtggtggg 1052101 tgtatctttg tattgtaggc atcattttca gcgcatataa acttgtggcg gcagccaaag 1052161 aggaagaaaa agtagaccag gcttttattg aaaaagaagg acagatttat atggagagga 1052221 tggaaaagga gcgagaacgc cgcagttctc agcagcatga agaagaaaat caaaaccatt 1052281 ccatcgcata aaaaaagctg tgcggctcaa tgagccgcac agcttttttt attatttaga 1052341 attgcttgaa gatgaagaag tgctgttgct tgttgaagat gtattaaatg tgtctttcag 1052401 atctttatct tttacttcga tgtcagcctt cttcatgact ttttgaacag cttcctgaac 1052461 agctgcgttg tcatttaatt tttgttcaag cacttcagat ttcagttctt ttttcatatc 1052521 atcatatttg ccgcgttctt ctgtcttttt aatgatatgg tagccgtatt gcgttttgac 1052581 aggatcactg acttcacctg tttttaattt gaatgcagct ttgctgaatg tttcgtccat 1052641 ttggccttct tttgcgaacc agccaagatc cccgcctttt gaagcagagc tgtctgttga 1052701 gtattctttc gcaaggtctt caaacttctc gccttttttc agctttttct ctacttcttc 1052761 agctgtcttt ttatcagcaa caaggatgtg gcttgcacgg attttgcctt ttaagccttc 1052821 ccagtactct ttgatatcgg cgtctgttac tttgatgtta tctttagccg ctttttgtgt 1052881 cagcaattca tattttactt gttctttcag gtaatctttg ccatattgct tttcgagggc 1052941 agtatattga tcgccaagct gcgttttgta ttctttcagc ttgttgtcaa tttctttatc 1053001 cgaaacttta tacttcttgt ccaatacttt ttcttgcact agctgtgtca gtacgcttgc 1053061 gccagctgtt ttcttcatgt ttgtgtaaag ctcgcctttt gtgacatcgc ctgcgtctgt 1053121 ttttgcgata acttctttgt cgccgctgct gcaagcactg agagcgagga tgcttgtagc 1053181 agtgatagct gctattgcga ttttcttcat tgttttcaaa cactcctaat cattccaaat 1053241 taaattacct atgcgtatca taacatattg tggctttctg taaaaagatt ttaaataaag 1053301 ggcattcgtc tagtcaaact tttgctgatg acatacttat atattgatca agaaaaggag 1053361 gtatgtaaca tgagcggagg atactctaac ggattcgcgt tgctcgtagt actgttcatt 1053421 ttgcttatca tcgtaggtgc agcttacatc tactaagcag cccgaggatc gcttgcaaca 1053481 taagcgatcc tttattttca ctagcgccta atcgtttcaa acatgaattg cataacatgt 1053541 aattggtaaa taaagcttat tacaggaggt gctatttaag atgggtgaag tatttgcagg 1053601 cggattcgct ttattggttg tgttatttat tttattgatt atcatcggcg cttcttggct 1053661 gtactaatca acataaaaaa gcatagctgc ttaatcagca gctatgcttt ctttcgtatt 1053721 tacactgtaa aggagatctc cacaaacgaa gagatcagta aaattaatat agatacatta 1053781 ataaatcgga ataccttatc ttgccgctct tcaggaatct ctctgacaag gcataatgta 1053841 ttggtgagcc tgtttatgaa atataaaata aacacggcag ccacgataaa atagaataaa 1053901 atgatgggag attccccctc tctctgaact gtcccatatt acattaccaa atatttatta 1053961 aaaaagatag aatgcaaatt gaaaaatcgc caccagcacc agggtttgac tacttttcaa 1054021 caagaatatc caagccgtca gcttcctgat caataaaagc ggttttcggt gcttttatca 1054081 gcttgagagc cagcaggaaa tcaggcagac agtagccggc gtgaatgccc gagatcatgc 1054141 aaaaataatg agcgtgattc ggaaatgcca gtgctgcgta aaacaatacc ggtgtaatca 1054201 gcaagaacgg gctgacgagt gaaatcagca ttgttgtttt tggtatacgt ttccatgtgc 1054261 gcatgcgcaa tatgtaaaac tttttttcta tttttctttt tttgcagatg attggcagga 1054321 catggatgac tttatgtaca aataaaataa cgacgagcaa accgccgaat aaagatacat 1054381 attcatcgct taagcttgtg ccaggccgca gcagctcaaa agctaaaaag gtagatataa 1054441 aaaccaaaat cataaaacat acagcagtta atattatgcg aacggcgcca taatccttca 1054501 tgagatttat ggtcttccag caattcatca aagtcatcct tccatacatc ttgaatagaa 1054561 tctcaaaata atttactcct cccaagagaa aaaatcaatg cttttttaag aaaaaatatc 1054621 atccggcagg tatttttttg aaacaagcaa acaaactgcg aaatatgggg ttagaacttt 1054681 cttctcagtg aattatcagc taaaataaga ttaaagatag aaagaagtgg tgtggatgga 1054741 ttcgatggat catcgcattg agcgattaga atattacata caattattag tgaaaacagt 1054801 agatatggac aggtacccct tctatgcgct tctcattgat aaagggctga gcaaggaaga 1054861 aggggaagcg gttatgagga tatgcgacga attgtcggaa gagctggcaa cacaaaaagc 1054921 gcaaggattt gtaacctttg ataagctcct tgcgcttttt gccggacagc tgaatgaaaa 1054981 attagatgtt catgaaacaa tttttgccct gtatgagcag gggctttatc aagagctgat 1055041 ggaagtcttt atcgacatca tgaagcattt tgattaactg tttacaggtt cgagctcttc 1055101 agccggttca tccgccgcac tgtcctttgc ttttttcttc aattttccgt ttacgctttc 1055161 aaagtcattg tcaatattgg tgagtgacgt ttcgaaaatt tccataaaat catcgccgta 1055221 gatatggcgt atcatacaca tcatttctgc cacttcagga aattttccga ataaatgata 1055281 taaaggctgt gaccctttaa aaacagcgtt gcgtgtcgga tcaaattcct caagcaagct 1055341 ccagaatacc tcggtacctt cctcagtcaa ttggacatat gtgttccgtt tatcattcag 1055401 ccgtttggag aaccttaaat atccccgttc ttccagcttt tttgaaaagt tgaatgcggt 1055461 tgatacgtgc atgaccccga atttcgcgat ttcagaaatg gaagctccat tcaattgata 1055521 cgcaatccat aaaatatgat gctcattaat attcaggtca tacggtttga gccattgctg 1055581 ccaatccttc tcgatcgatt tccaaagagc cttgctaagc tgagccattt tctgggtgaa 1055641 aaccagagct tctttcacat catagggcgg ttccactcga ttcattacgt cacctgcttc 1055701 tctttttctt tttctctatt atgccaataa aataaagatt aataaagatg aaaatgtaag 1055761 aattttttaa taaattcaca aaccattgcg acgaaagggt ttttcggcca aaaaaaatac 1055821 gggtccaatt ttggcccgca tttttttctt ttgaatagga tattagtttt gtaaggtttt 1055881 ctccagctgt ctgattttct cttcgatatc ggcaatttct ttttgcagat cctgctggtg 1055941 aggcttgatc tcttcctgcc attttttaat tgatgtttgg agctcgccgc ccacgtcttt 1056001 aataacatcc gtgctttctt ttgccgcttt gatcagctgg tcttttaatg caagcccgtc 1056061 tgactttaag cgtttgattg tttcttcaaa agaatcataa ttggttttca ttttttcacg 1056121 cagctgcttt cctgaggaag gtgcagtaag aagaaccgct gctcctccga tgatgccgcc 1056181 tacgaatagt cctgttaata gagaacgtcc gctcgccatt acaatcaccc cgtctttttc 1056241 ttcaaaatag gattcattca gcatttttca tttttgttga aagcctgaac ttctatacat 1056301 agcttgcttt attttagcat attttttaag tgaaaaggag ggagaaggtt gtctgtcttt 1056361 ttgattgtat tatcctgcat cacccttgcc ttcgcttcag gcgctgttta ctatatcaaa 1056421 cttctcagcc aggctgcttc ttatccgccc aagagggtta tccggcagaa agcgcttgtt 1056481 tgttcaaccg gaaccgcctt tacactatgt cttatctttt tcacaaaact cctcgcttaa 1056541 aacatgctga catgctgcgg gcgctctgtt caaaaaaacc tctcccggaa gcggaagagg 1056601 ttttgtgtga caattattta gcagcttcca taaagcttga acgccttaaa atggtttgca 1056661 caatcggata aataatgatc attgagattg tattcagcac agcggccggc agaacaacag 1056721 ccgcgaacaa tgcggcgaaa ccgcccggta aaccgacgat caataaagct gacgatagaa 1056781 acacaattcc tgataagatg gtcccgatca ctgtcagcac agcggctgca cctgttttcc 1056841 ggctctttct gaacaagaga aacagggaga agaacagaaa cgctgatacg ggtttatcaa 1056901 tgatgttagg gatctgtccg gctggaaacg cggttgtaag cgcggaaatg attccggtca 1056961 cgatcccgat gacgagtaca ttttgcaccc gcgggaacag cagaatgccc atgaacatca 1057021 tgatcagcat catatctggt ttcatgccgc ctaaaaaggg cggaataatg gaatgaagcg 1057081 ctgcgccgat tgcggcaaac agagccataa tgactaactc ttttgttttc ataactatgc 1057141 tctcctctgc taagcttttt gccctccaat aatatgctca tcatttattg cgaaggcttt 1057201 acagaatgtg ttatgcaaac agtataccaa acggacggtt tgcatagcca gactttttac 1057261 tcattttcct gctggaattt cttcatgaac gcagctaatt tttcacagtc ttcgagagag 1057321 accgcgttat aaatagaagc gcggcagcct cccaccgaac ggtgtccgcc aaggccgatc 1057381 atcttcgcat cttttgcttt ctgaacgaat gttttcgtta attcgtcatc ccgaagcgtg 1057441 aatgtgacat tcatgcgtga gcggctgtct tttctggcat gtcctttata gaagccgttg 1057501 ctttcatcaa tacagctgta gagaacctgc gctttttgtt cattgcgctg ttcaacagct 1057561 tccacaccgc cgttttcctt gagccattcc agaacgaggc tcagcatata aatcgcaaat 1057621 gtcggcggag tgttgtagag tgaatccgct ttgacatgcg tggaatattt caagattttt 1057681 gggacgttcg cattttcatt ttgcagccag ctttttttca tgatgactac agtcacgccg 1057741 gaagggccga ggttcttttg ggcgcctccg tagatcacat caaatttgga cacatcgatt 1057801 tttctgctta aaatatcgct ggacatgtcg gctacgagcg gaattggaga attcggaaac 1057861 tcctgccact gagtgccgaa aattgtattg ttggatgtga tatgtaaata tgcgccgtct 1057921 tttacatccg taaggtcaac ctctggaata taactgtaat tgtctgtttc acttgtagcg 1057981 gtgatagacg tgttcccgaa cagtttcgtt tctgccagtg ctttttcaga ccaagcgccg 1058041 gtcatcacaa aatgtgcggt tttttcaggt gttaaaaagt tcatcggaag cattgagaat 1058101 tgaaggcttg ccccgccttg aagaaacaag atatcgtaat cttccggaat gcccatcagt 1058161 tcgattaaga ggcttttcgc tttttggtgc accgcttcat actctttgct gcggtgggaa 1058221 agctccataa cagacatgcc ggattcgtta aaatcaataa attctttctg tgctttttgc 1058281 agaacttcca gtggcagcgc tgcaggacct gcgttaaaat tcgttgtacg ttccattatg 1058341 atctctccct gttttccacg ttaatgtata aaataataca attatcctat cacaaaaatt 1058401 cagttttttg ataaaaaatt agaattatca aaagaaattg acggatgttt gcgaaatgtt 1058461 cacaaaataa aataacctca tcttatgatg aggccaggcg ttttgcgata gaggaagaga 1058521 tgttctgcag atcctccggt ttataatcat cagcatgcgt tttccaaacc gctccgaatc 1058581 catctccttt tccgtagcga gggataatat gcatatggta gtggaacaca gattgtccag 1058641 ctttttcgcc gttattgttc agcgtattta agccgatcgg ttcaaattca tcccggatag 1058701 cgcgggcgat ttttggaaca gcatggaaat attgttttgc taattcatct gtaaattcat 1058761 atacattctc aatatgtgtt ttcggaatga caagcgtatg gccttttgtc acttggctga 1058821 tatcaagaaa ggcaagtaca tgttcatctt catacacctt cgctgatgga atgtcgccgg 1058881 caataatttt acaaaagata caattctctg cacaatgcat gagggttcct ccttatgaaa 1058941 ttgtttagta tgtatacatt catcgtacca cagaaatgca gaaaatagaa aacaggatga 1059001 acggcgagcg ttcaccctga atgcagagga agagcttata tgaagaaaat gtgttatgcc 1059061 tttggtaagc acctcatttg tcaataaaat gaagacttgt ttaatgccta acgattcctg 1059121 cgataaacac ctcatttgac aatttgcttc atacatgaag aattcatcaa ttcagtgaag 1059181 agaaatggtt tgagcattgg acatgtttat tttctatcca actgtttcta agacgtcttt 1059241 gacaaacacc tcatttttca gttgatatgc ttttcctcta caacttttat gatgtccaga 1059301 accctgtctc tttatgacag caaattcatc atttgttaaa agggaattgt ttcaaatcag 1059361 gccttgtttt tggtactatg aagaaaaaca ctataagggg agaaactatg tctctgctat 1059421 cggtaaaaga cttgaccggc ggatatacaa ggaatccggt tttaaaaaac gtatcattca 1059481 cccttgaacc gaatcaaatt gtcggcttaa tcgggctgaa tggtgctggt aaaagtacaa 1059541 caatcagaca catcatcggg ctgatggacc cgcataaagg ttcaatcgaa ttaaacggta 1059601 aaacgtttgc tgaggatccg gaaggctacc gttcacaatt tacctatata cctgaaacac 1059661 ctgttttata cgaagaattg acgctgatgg agcatcttga actaacagcc atggcatatg 1059721 gactgtcaaa agaaacgatg gagaaaaggc tgcctccgct actaaaggaa ttccgaatgg 1059781 aaaagaggct gaagtggttc ccggcccatt tttctaaagg aatgaagcag aaggttatga 1059841 ttatgtgcgc atttttggca gagcctgcgc tctacattat tgatgagcct tttctagggc 1059901 ttgatccgct tgccattaac gcgctgcttg aacggatgaa tgaagcgaaa aaaggcgggg 1059961 cgagcgtgct gatgtcaaca cacattttgg caacggcaga acgctattgc gattcgttta 1060021 ttattttaca taacggcgag gtgcgggcgc gcggcacgct gtcagagctc agagagcagt 1060081 ttggaatgaa ggacgcggcg ctggacgatt tgtatcttga gcttacaaag gaagacgctg 1060141 gccatgaata atatgcttga tatttggcag tcgcggctgc aggagcatat caaagaaaca 1060201 agaacataca tgaaatatat gctcaacgat cacctcgtca ttgttttgat tttttttcta 1060261 gcgggcgctg caagctggta cagcaaatgg atacgggaca ttcccgctca ctttccgtcc 1060321 ttttgggtga tggccgtgct gttttcgctc gtattgacaa gctcttatgt gcgaacgctt 1060381 ttgaaggagg ctgaccttgt tttcttattg cctcttgaag caaaaatgga gccttacttg 1060441 aagcaggcgt ttgtctacag ctatgtgtct cagctgtttc cgctgattgc gctgagcatc 1060501 gttgcgatgc cgctttattt cgcagtcact ccgggagctt cgctcgtatc gtatgccgcg 1060561 gtctttgtcc aactgttgct gctgaaagcg tggaatcagg taatggaatg gcgaacgact 1060621 ttccaaaacg accgcagcat gaaacggatg gacgtcatca ttcgctttgc ggcgaataca 1060681 ctcgttcttt attttgtttt ccaatctgtt tatatgtatg cgcttctcgt ctatgtcatt 1060741 atggctgttc tttatctgta tatgtcttcc gcagcaaaac ggaaaacatt taaatgggag 1060801 agccatattg agtccgaatt gagacgaaag cagcgtttct atcggattgc caacctgttt 1060861 actgatgtgc cgcatttgcg aaagcaagcc aaacgcagag cttatctcga ctttttgctg 1060921 cggcttgtgc cgtttgaaca gcgcaaaaca tttgcctata tgttcacccg cgcctttttg 1060981 cgttcgagcg attatttggg cattcttgtc agattaacga tcgttttcgc gctgatcatt 1061041 atgtatgtct cagccagccc gctgattgcc gcggttttga ctgtgtttgc cattttcatt 1061101 acgggcattc agcttctgcc gctcttcggt cactttgacc atctggcgct tcaagagctg 1061161 taccctgtgc aaaaagaaac aaagctgaaa agctatttct ctctattaaa aactgcactt 1061221 agtattcaag cgctgctgat gtctgttgca tctgcctatg cagccggctt gaccggtttt 1061281 ctgtacgcgc tgatcggttc tgccgttctg atttttgttg ttttgcctgc ttatatgacg 1061341 accaggctga aaaagcacgg aaagctgtga actgaaaaga ggtaatcaaa tgacagataa 1061401 tcagctgctg atgcaggaag ctttggaatg gaaaatgcat tttttgcgaa aggattccat 1061461 gtttgaacgc ttttcgaagc gtgtccagac gaaggtgaat gaacggattc ctgaaaaaat 1061521 ccatacggtc gtcaccgaga gtgtgaaaaa aatggtagaa gcgacaatgg ccggctctaa 1061581 tatcatcacc tataaaaagg atacaagtgc actgtcgctc agtgaaaaaa acgaattggc 1061641 gaaaaaaacg attgtttctt atcaaaaagt ggcagctgct gagggagtcg gcaccggagc 1061701 gggcggcatt tttttaagca ttgctgattt tccgctgctg ctttcaatta agatgaagtg 1061761 tttatttacc ttgtcttcca tttacggctt tgatgtcaag gatgcacaag aaaggatatt 1061821 tttgctgctc gtgtttcagc ttgcgttttc gagtgatgat ggccgtaagt cgcttttttc 1061881 tgtcatcgaa aattgggaga cggagaaaaa gagcatcgac tggagagtgt tccagcagga 1061941 atatcgcgat tatatcgacg tcgtgaagct ttttcagctt ttgccgggcg taggagcggc 1062001 agtcggcgga attgccaatt ataagctgct tgctcagctt ggagaaacgg caagacatgt 1062061 ttttcatctg aggatattaa aggaaacagc cggagaataa acactccggc tgttttttta 1062121 tagctgatga taggtgatcg cagcgccggc aaggaccttg gccgctgtca gcatggcttt 1062181 ttcgttgata tcaaatttcg gatggtggtg ggaatagact cgctctggct gttcgggagc 1062241 ggcgcctgta aagaaaaaag tgcccttcac gttttgtaag taataagcaa aatcctcgcc 1062301 gcccatttgt ggttcaccgt caatgacctg ctgaacgccc tcggtattct ttgcggtgct 1062361 caccaagtgg ttcgtttctg caggatggtt cacaaccgct ggataaccct gttcataggt 1062421 gtactcatag gacgcgccgt gcatgctgca tattcctttt acaaccgctt caatttcttt 1062481 ctccagaatg tcccggacat tttcatcaaa agaacgcgct gtgccgatga gtactgcttg 1062541 gtctgcgatg acattaaacg gattgtcggc gatgaaggag cctgtcgaaa tgacggcgga 1062601 ttgaatcgga ttgactttgc ggctgacaat gtgctgcaaa gaggaaacga tttgcgaacc 1062661 gattaggacg gcgtctttag tatcatgcgg atgagcgccg tggccgccct ttccgaagac 1062721 tttaatcgta aatcggtctg ccgccgccat tacggcgccg gggcggcaga gaatagttcc 1062781 gagcggctca gttgcccaaa gatgagtgcc gaatatcaca tccgtgtttt cgagacatcc 1062841 gtcatcaatc attggctttg cgcctccagg ataatattct tctgcatgct ggtggatcat 1062901 cacaaatgtt cccttcagtt catgtctgtt ttggtgaagg accttggcca ctgcgagaag 1062961 agctgcggtg tggccgtcgt ggccgcatgc atgcatgaca ccaggcactt tggaggcgta 1063021 agggacatct ttttcatctt gaatggggag agcgtcaaag tcggccctca aagcgactgt 1063081 agggccgggt tcgcttcctt ctatatttgc taaaacccct ctaccgccaa cgtttgtgcg 1063141 gattgggact cctaacgatt cataatagga agcaataaat gcggcggttt tttcttcttg 1063201 aaatgagagc tcaggataca tatgaaaatg gcgcctgatc tcaaccattt cttcaaaaca 1063261 gccgtcgagc tgtttgttta tctctttctg cagtgtggat atggacaaag ccgcttcccc 1063321 cttttctatg cttttccatg attgtataga aaaagtctga atatttcaac tcatgctgtt 1063381 ttaaagcatc atcacagctg cgagggttgt caccaaaagg ccaatcgcga cgggaatgaa 1063441 gttttttctg gcaagctcaa aaggatcaac tttgcaaatg gccgcggcgg gaatcaaagc 1063501 ccatgggacc agtgttcctc cgcccaccca gatggcagag atttgtccga gcgcggtcag 1063561 aatagcggga tcggcatgga gagcggacga aaagagcttt gcgatggagc cggcgagaga 1063621 aatgccagaa aatcctgagc cgtcaaggcc tgttatggct ccagcggcag ttaatgcagt 1063681 ggcggcaagc tcctttgaca taggcatcat atgggataaa gcaatgccaa gatcgttgac 1063741 aatgccgtgg gaacctttag ggagtgaagt gcccagtatg ctttcatagc ctgagtcgcc 1063801 aagataaaag aaagcggcaa tcgggatgac ggggccgaaa accttaaaac cgaacttaaa 1063861 tccgtcaata aaatagccgg tgattttttc aagcccttta tgcttataca cgaaaaaatg 1063921 aacggtaaag aggatacaaa ttgcagaccc gccaattaac gcggttgcat catttccttg 1063981 taggttaaac aagagcatgc aggcgatatc tgcaagaaag gcaagcggaa tcaaaaaagc 1064041 cagtatggac cgcaggcgtt ttggcaagta cagcgagttg tcttgttcgc cggaaagaac 1064101 gggggaaaaa gaagtgggat gctcctgttt tttgcgttcg cgctgaatca tgataaaggc 1064161 agcagttgtt gttgtcacac ccataatcag cacaagcgga atactggccg agacgacatc 1064221 accgactgga atgcctgctg catccgcagt cagctttggc gccgcctgaa tgacaaagtc 1064281 tcctgacagg gcaaaaccgt gtccgaataa gttcatggcc atggccgcgg caagaggcgt 1064341 caaaccggca cgtgcggctg cggggagcag gacggcgccg atcaaagcga cacccggaga 1064401 aggccagaag aatagagaaa tggcgaacat caggcctcca atcagccaat aggcagtcac 1064461 aggccctctc acaaggcttg caaagggaga aatcatcgct tcatttatcc ctgtttttgt 1064521 taacaaatca ctcattgaaa cgataaagca aatgatgaaa atcgtgggca gcagttcgcc 1064581 ggccgcatag ataaagctgt ggaataaact gctgacagaa gctgaaagtg aatggctggc 1064641 ccatagcgat atgataaaaa tgccgaatag agaaataaat gtcgtgtctt ttctcagcag 1064701 cataaatagg ataattgcac cgataaaaaa cacatacaga acatggacag gcaaaatccc 1064761 gacttccatc atcgatcact ccttccgctt acagattatt cataggcggg cggaaggtgc 1064821 cgggacagag gggagggtta tgatggaaga tgaacattga tctgtttcag ctgctcaatc 1064881 agatgatgcc ttaatcctct attcgctttt tgcagatgtt ttgggaagca ttcaggagaa 1064941 aaaatgacgc acccttcagc aagccagttt tttctatagg cgatgatgct ttccgatggc 1065001 tctatatgag ttatcctcgt gctgcatctc gtactcatca aatccgaact gaaaaccgca 1065061 gcacgggcag atttcatgag aatgattgcc ttcatgatca tatggcggtt cagccaatcc 1065121 ttaaacccgc agactgggca agtatgcttc attttgcttt cctcccaata aaataagctg 1065181 ccggacatgc cggcagctat tcgacagcga aatatgtggt gacataggaa ggccgggaga 1065241 agatcgacgt tgtgtcaatt ccggcagatg tatcgcgttt tttgtgggct tctttgtaag 1065301 aaccggactg ctgccagtct tgaaaggcgc tttccgtttc ccacaaggtc agaatgacat 1065361 aggtgtcact gtcaagcgga cggagcactc gaattgcttc aaagccaggc tcgttttcga 1065421 cttttcccgc tctgttttta aatctgtttt caaacagcgg acgcccttcc tgagtaacgg 1065481 caatattgtt caatactgca aaaccgggat gtttgatctc tccgacttgg tcaatgactt 1065541 cataagcgtg tggtgcctgg aaaacggtat ctccgtttgt ttcatgaatt aaaatggcgt 1065601 tttcctgccc ctgcatcaaa aggatatttt ctgagggatg cttctgtacg atcgttttta 1065661 aaaaatcggc tgtcccatat gtaatataaa ccttcatatc agccacctcc tgcttgctag 1065721 tatatcaaaa caatggtata agtttctatt ggcgagtgct tcgaacataa ttccaaacaa 1065781 tttttcccat actaccttta gaaaggcgag gtgagttcat gtttaagata aagaaaaaga 1065841 aactttttat acctatcatt attttagtgt taactgcttt tctcgcttta ataggatata 1065901 tttcaattat ttttctcggc cattatgtca tagatgaaaa aaagcttatt cttcatgctt 1065961 cttcaaaaat tgttgatcaa aacggagatg aggttgcaag cctgtataca gaaaatcgcg 1066021 agccggtctc gatcaatgag attcctaagc aggtcagaga agcgtttatc gctgttgagg 1066081 ataaaaggtt ctatgagcat cacggcattg atgcaaaatc cgtcggaagg gcagtgtacc 1066141 gcgatatatt agcaggcgga aaggtggaag gcggaagcac gatcacccag cagcttgcca 1066201 aaaatatttt tctgacacat gacaaaacat ttctaagaaa aacaaaagaa gtgatcattg 1066261 cgattaatct tgaacgggat tacagcaagg acaagctgct tgaaatgtat ttaaaccagc 1066321 tttacttcgg acacggggtt tacggcatac aagcggcgtc ccactattat tttaataaag 1066381 aagtaaaaga tttgactgta tctgaaggcg ctgttttggc cgctattccg aaggcgcctt 1066441 ctacgtactc tccaattttg caccctgata aaaataagga gcggcgtgat acaattctag 1066501 gtatgatgaa tgaccaaggc tatatcagtg cgaaagaggc tgtcaccgca cagggccgga 1066561 cgcttggact gcatgtgaag aaacagtcgg aaacaccttg gtttgacagc tacattgacc 1066621 ttgtgatcaa agaggcggaa gacaagtatt ccatttccgg agagcagctt cttcaaggcg 1066681 gatacacgat caaggtgccg ctcgattcga agctgcagaa gacggcttac caggtgatga 1066741 aagagggaag ctattatccc ggaacagatc agaatgccga gggaagcgcg gtctttatta 1066801 ataacaagac aggcggtgta gaagcggcca tcggcggaag ggattacaca tccaaaggat 1066861 ataaccgtgt cacagctgtc cgccagccgg gttccacatt taagccgctt gctgtatacg 1066921 gaccggcgat gcaggaaaag aaatttaagc catattctct attgaaggat gagttgcagt 1066981 cctacggaga ttatacgccg aaaaactacg acagccggta tgagggcgaa gtcactatgt 1067041 ctgacgccat tacgtacagc aaaaacgcgc cggctgtctg gacgctgaat gagatcggcg 1067101 tcgaaacagg gaaatcttat ttgaaagcaa acggcattga tatccctgat gaaggccttg 1067161 ctcttgctct aggcggcttg gaaaaaggcg tttcaccgct ccagcttgcc ggcgcgtttc 1067221 atacatttgc cgcgaatgga acgtatactg aacccttctt tatctcgagc ataatagatg 1067281 aagacggaga aacaatagcc gatcataaag aagaaggaaa gcgggtattc agcaagcaga 1067341 cgtcttggaa tatgacgaga atgctgcagc aggtagtcaa aaagggaacg gccacgtccg 1067401 gcacctatca cggcgacctg gcgggaaaaa caggttcaac atcttataca ggcgtctccg 1067461 gcgcgacaaa ggacgcctgg tttgcaggct atacgccgaa aataaccggg gcagtctgga 1067521 tgggctatga caaaacggat caaaaccatt atttgaaagc cgggagctca tacccgacgc 1067581 ggctgtttaa ggatattttg acacaggcag gagaaaccgg tcatgtgttc acaaagccta 1067641 aaaacgttaa agaactggaa agcccgattg agctgaagcc ggtcaaaaca ctcacagccg 1067701 attacacatt taaagcagcg gggctcttta ctattgaatt aaagtgggac gctcaagagg 1067761 atgatcgggc cgtatacaga atttatgtaa acaaggacgg cgaggagacg cttcttgatt 1067821 cggttgaagg gaagggaagc tatgaaattc cttatgccaa cttattttcg ggcgcgtctt 1067881 ataaaattgt gccttataat acacagacaa aaagagaagg ggaaggaacc gattacgttc 1067941 agccaaaatt gttttcctct taatggaatt cggcgatttt ttgaactttg agctacattt 1068001 ctataccatt tgcctaaaac aaggtatagt gtaataagtc aagaaatacg aacgtatggt 1068061 tgccgtatga aaggtggaaa tcagatgagt aaacgagaaa cgtttaacga gacgttttta 1068121 aaagctgcgc ggggagaaaa agcggatcac acgcctgtgt ggtatatgag gcaagcaggg 1068181 cgctcacagc cggaataccg caagctgaag gaaaagtacg gattgtttga gatcacacat 1068241 cagcccgaac tttgtgcgta tgtcacaaga ctgccggttg agcaatacgg agtcgatgct 1068301 gcaatccttt ataaagatat catgacgccg ctgccgtcaa tcggtgtgga tgttgaaatc 1068361 aaaaacggga tcggtcctgt gattgatcag ccaatccggt ctctggcgga cattgaaaaa 1068421 ctcggccaga ttgatccgga acaggacgtg ccgtacgtgc ttgagacgat taaactgctt 1068481 gtcaatgagc agctgaacgt cccgctcatc ggtttctcag gtgcgccttt tacgcttgca 1068541 agctatatga tcgaaggcgg cccgtcgaaa aactacaata aaacaaaagc cttcatgtac 1068601 agcatgccag atgcatggaa tctgctgatg tccaagcttg ccgacatgat catcgtgtac 1068661 gtgaaagcgc agattgaggc aggcgcaaaa gcgattcaaa tctttgattc gtgggtcggc 1068721 gcattgaatc aggcagatta cagaacatac atcaaacccg tgatgaaccg gatcttttca 1068781 gagctcgcaa aggagaatgt gccgctgatc atgtttggcg ttggcgcaag ccatcttgca 1068841 ggtgattggc atgaccttcc tctcgatgtt gtcgggcttg actggagact cggcattgat 1068901 gaagccagat caaaaggaat tactaaaaca gtgcagggca acctggaccc gtccattttg 1068961 cttgcgccat gggaagtcat tgagcagaaa acgaaggaaa tacttgatca gggtatggag 1069021 tcagacggct tcattttcaa tcttggccat ggggtatttc ctgatgtcag tcccgaggtt 1069081 ttgaaaaaac tgacagcatt tgtccatgaa tattcacaaa acaaaaaaat gggtcaatat 1069141 tcctaagcat atcttttggt atcttaatga tatcctgtca aaatgtttgt atcagatcat 1069201 taaagagggt gtaaacagtg agtagaaaga aaatggggct tctcgtgatg gcgtacggca 1069261 cgccttataa ggaagaagat attgaacgtt attatacaca tatcagaaga ggcagaaagc 1069321 ctgaacctga aatgcttcaa gatttgaaag acagatacga agcgattggc ggcatttcac 1069381 cgcttgccca aatcacagaa cagcaggcgc ataatctgga acagcacttg aatgaaattc 1069441 aggatgagat tacgtttaaa gcgtatatcg gactgaagca tatcgagccg tttattgaag 1069501 acgccgtagc agagatgcat aaggatggca ttacagaagc agtcagcatc gtgctggcgc 1069561 cgcatttctc cacgttcagc gttcagtcct acaacaaacg cgccaaagaa gaggctgaaa 1069621 aactcggcgg cttaacgatt acgtcagttg aaagctggta cgatgaaccg aagttcgtga 1069681 catattgggt tgaccgagtg aaggaaacat atgcgtcaat gcctgaggat gaaagagaaa 1069741 acgcaatgct catcgtatcc gcacacagcc tgccggaaaa aatcaaagaa tttggagacc 1069801 cgtacccgga ccagcttcat gaatcggcga aattaattgc tgaaggcgca ggcgtttccg 1069861 aatatgctgt cggctggcaa agtgaaggga acacgcctga tccttggctc ggacccgatg 1069921 ttcaggattt aacacgtgat ttattcgaac aaaaaggcta tcaagcattt gtatatgttc 1069981 ctgttgggtt tgtcgcggat cacttagaag tgctttatga taatgattat gaatgcaaag 1070041 tggttactga cgatatcggc gcaagctatt accggccgga aatgccaaat gccaagcctg 1070101 aatttattga tgctttggca acagtcgtat taaaaaaatt aggacgttaa agaaggcgat 1070161 gaacatgagt gacggcaaaa aacatgtagt catcatcggc ggcggcatta ccggtttagc 1070221 cgccgccttc tatatggaaa aagaaatcaa agaaaagaat ctgccgcttg agctgacact 1070281 tgttgaggca agtccgagag tcggcgggaa aatccagact gtcaagaaag acggctatat 1070341 catcgaaaga gggccagact catttctgga acgaaagaaa agcgccccgc agcttgttaa 1070401 agacttaggt cttgagcatt tgcttgtcaa caatgcgacc gggcaatcct atgtgcttgt 1070461 aaaccgcacc ctgcatccaa tgccgaaggg cgctgtaatg gggataccga caaaaattgc 1070521 gccgtttgtt tctacgggtc tgttttcctt gtccgggaag gcgagagctg ctatggattt 1070581 catcctgcct gcaagcaaaa caaaggatga tcagtcattg ggagaattct tccgcagacg 1070641 tgtcggagat gaagtggtcg agaacttaat cgagccgcta ctatcaggga tctacgcagg 1070701 cgacattgac aagctcagcc tgatgtcgac atttccgcaa ttttatcaga cggaacaaaa 1070761 gcatagaagc ctgattctcg gcatgaaaaa aacaaggcct caaggctcag gccagcagct 1070821 gacggcaaaa aaacaagggc agttccaaac tctgtcaacc ggtttgcaga cccttgtaga 1070881 agagatcgaa aagcagttaa agctgacgaa ggtgtataaa ggcacaaaag tgaccaaact 1070941 tagccatagc ggctcttgct attcgctcga actggataac ggcgtcacac ttgatgctga 1071001 ttcagtaatt gtgactgctc cgcataaagc ggctgcggga atgctttctg agcttcctgc 1071061 catttctcat ttgaaaaata tgcactccac atccgtggca aacgtcgctt taggtttccc 1071121 tgaaggctcc gtccaaatgg agcatgaggg cacgggtttt gtcatttcaa gaaacagtga 1071181 ctttgcgatc acagcctgta cgtggacgaa taaaaaatgg ccgcacgcag cgccggaagg 1071241 caaaacgctg cttcgggcat atgtcggaaa agccggagac gaatccattg tcgatctatc 1071301 agataatgac attatcaaca ttgtgttaga agacttaaag aaagtcatga acataaacgg 1071361 cgagccggaa atgacatgtg taacccgatg gcatgaaagc atgccgcagt accatgtcgg 1071421 ccataagcag cgtatcaagg agctgcgtga agcacttgca tctgcgtatc cgggtgttta 1071481 tatgacaggc gcttctttcg aaggtgtcgg cattcccgac tgcattgatc aaggaaaagc 1071541 tgccgtgtct gacgcgctta cctatttatt cagctaaaac ctccgcttta tcgcggaggt 1071601 ttttttgatg tgcaatggca atattgtgta aaaaatgatt gaattgaaca gcaggttatg 1071661 atacatttgc atatgtactt aatgactaaa atgttcaaac ggtcagtttc gaggtgaata 1071721 caatgtcaat agatcgaaaa aagctcattt tggaggcggc tacaaagtct ttcacgcagt 1071781 tcgggtataa agcgacgaca atggatcttg tcgcaaaact tgcgaacgtg gggaagggaa 1071841 ccatttatac ttttttcaaa aacaaagaag agctgtttga cgagattttc actactttat 1071901 taaaggaaat gaagcaaaaa gcggatgaag cgatggagcc gagccttccg ttccatgaaa 1071961 atgtgcacag agcgctgttt gccattctgg agttcaggaa aacacatcag ctgacgatta 1072021 aaattttcca agagaatgcc gagattggta caatggcagt tcaggaagtg atccagaaaa 1072081 tggagcgatc catcctgtct tatatcaaaa gcaagattga agacgggatc aaaagcggcg 1072141 caatcaagcc gtgcgaccct gagctgacag cctttgtgat gctgaagctt tatatcgcgc 1072201 tcatttttga ctgggaaaaa caacaccccc cgcttgataa agagacaatt gcgggactgc 1072261 ttgaattgta tgttgtcaaa ggattgtcag cgaactagat aatcctttct ctttgcaaga 1072321 aaatgaccat tttttatgat gagtcagttt tagaatggag gcatcaggat gaacacaata 1072381 cgaagtcagt ggaaagacat cgtaacaagt aaaaaattat tgattcccat catcgccatt 1072441 ttgtttgtcc cgcttattta cagcggcgta ttcttaaagg cttattggga cccgtacggc 1072501 acagttgacc agctgcctgt cgttgtcgtc aaccaagaca agggagcaac gtatgaagga 1072561 gaaaaacttc aaatcggtga tgatctggtc aaagaattaa aggataataa caactttgat 1072621 tggcattttt ccaatgatct cgaccaatcg ttaaaggact tattgaatca aaaatattat 1072681 ttagttgtcg agattcctga ggatttttct aagaatgcca gcactgtatt agacaaaaat 1072741 ccgaaaaaat tggatctgaa ataccataca aatgcaggtt ctaactatgt aggggcaacg 1072801 atcggcgaaa aagcgattga taaactgaaa gcctctgttt caaaagaagt gaccgagcaa 1072861 tatacgaaag ttatttttga taactttaaa gatatcgcaa aaggtttgag cgacgcgagc 1072921 agcggcgcga aaaaaattga tgacggcaca aaggatgcga aaaacggaag cgcccagctg 1072981 aaagaaaatc tggcgaagct gaaggaaagc accgctacca tcagtgacaa aacagcgcag 1073041 cttgcagatg gagcggctca ggtgacgagc ggcatccaat cacttgacag ctcgctcggt 1073101 aaattccagg acagcagcaa ccagatttat gataaatcta gtcagcttgc agcaggatca 1073161 ggcgagctga caagcaagat gaatgaactt cttgccggac ttcaaaatgt gcagaagggt 1073221 acgcctaatc ttactaacgg gttggatcag ctcaacagta aagtccaaga aggttctgag 1073281 aaagcggcaa aagcggaaaa gatcattaat gcgctcgatt taacgaagct tgaaactgct 1073341 gtaaacaatc tggaaaagtc agaaactgcg atgaaggaat tcaaaaaaca gctgactgac 1073401 tttgaaaaca gtttgaaaaa ccgtgatcag gcatttaaaa atgtcatcaa ttcgagtgac 1073461 ttcttaacag cggagcaaaa aagccagctg attaattctg ttgagaaaaa gcttccgcaa 1073521 gttgatgcgc ctgattttga tcaaatatta agccagctac ctacagctga tcagctgcct 1073581 gacatcgcaa cgataaaaag ctctcttgaa gacgtgaaag cgcaggtggc gcaggtgaaa 1073641 gccatgccgg aagctacatc taagctttat aacggcgcaa aaacaatcca agatgcgatt 1073701 gacagattaa ctgagggagc tgataagata tacaacggtt ctcagaagct gacagatggc 1073761 caaactaaac tgacagcggg catcggtgaa tataataagc agttcgcaaa agcaaaagcg 1073821 ggctcagagc aattggtgac aggaagcagc caagtatccg gcggattgtt taagctgtta 1073881 gacgggtcta aacaggtcca aagcggatca tcaaaacttg cagacggatc tgcatcactt 1073941 gatacaggtt taggcaagct attggacggc acaggagagc tgtctagtaa gctgaaggat 1074001 gcggctgacc aaacaggaga tatcgatgct gatgatcaaa catacggcat gtttgcggat 1074061 ccggttaaaa ccaaagatga tgccattcat tccgttccta actatggaac agggctgaca 1074121 ccttatatcc tgtcaatggg cttgtatgtc ggcggcatca tgctgacggt tgtcttcccg 1074181 ctgaaggaag cgtcaggacg tccgagaaac ggttttgagt ggttcttcag caaattcaat 1074241 gtcatgatgc ttgtaggaat cattcaatca ttgattgtgg cgacggttct tctattggga 1074301 attggtcttg aggtagagag cacgtggaga ttttacgtgt ttacgatcat tacgagtctc 1074361 gctttcctgg cgataattca atttttggct acaacgatgg gcaacccggg gcgatttatc 1074421 gcagtcatta ttttagtgct gcagctggga gcgagcggag gaaccttccc gctggaattg 1074481 cttccgaatt tctatcaggt catccacggc gcattgccga tgacctacag cattaacgga 1074541 ttcagagcag tcatttcaaa cggtgacttt ggctacatgt ggcagatggc cggcgtctta 1074601 atcggcattg ccctcgtcat gattgcacta agcattactt actttacaat gttaagccgg 1074661 aaggaagaaa catcagaaga acagccggct tcataaagaa aaagaacttg tttccttgga 1074721 aacaagttct ttttttgtta catcccccat ttaataagca atcctgtata ggttaatccg 1074781 ccgccaaacc cgaaaagcaa aacgatttga tcttttttca gcttcccggc tttcactgcg 1074841 agatcgagcg ccaaaacaat tgaaaccgaa gacgtgtttc cgtagtgctc aacactagtg 1074901 agcgtttttt caatcgggaa cggtgttttt tcacaaattg actcgatcat gcgcaagttg 1074961 gcgctgtgag gaacaaacca atcgagatca tcggagctga gtcctgcttt atgtaaaagc 1075021 cgttcaaatt cgccagggac ggttcttgcg gcccatttat atacctcgcg tccgttttgc 1075081 accatttttc cggaaccgac aagctgcaca ccgtttattt catttcgcag tccggcacga 1075141 tacaaaatat cgccgccgtt cccgcttgtt ccttgtacag acgcaagaaa tcccggcgtc 1075201 tcttcatctc gttctactaa cagcgcaccc gcggcatcgc cgaacagtac gcatgtcgtt 1075261 cgatcggtat aatcggttac ctttgataac gtctctccgg cgatgacgag aattttttga 1075321 tgaaggccag atgtgatcaa tccatttgcc aaatggaggc cgtatgtcag cccggcgcat 1075381 gtcgcattaa tatccagcgc gccggtgctt tcccagccga aatattcctg tacgcggcat 1075441 gccgtactcg gaaaggcgta atcggatgtg gttgtggcaa cgaggatcat atcgacatca 1075501 tcaagcgttc ctttataacg gctcttgaga ttcttcaccg cttctatgca taaatcagag 1075561 gtaaattgat gttcatccgc aatccggcgt tctctcattc ctgtgcgctg aacgatccat 1075621 tcatcagagg tatcaacgat cttttctaaa tctgcattgg ttaaacgtct gctcggcgca 1075681 taggtgccga tagctgtaat ttttgctttt gacatatgaa tcactcctta tggtcagatt 1075741 ataacactag atattagtat ctggtactaa aaagaaggtt tttttacaaa aaaagagaag 1075801 tgtagatagg aatctatgaa aaagaaaaag gaggctgaaa aatggtcagt caagaagcag 1075861 tagtcttttt ggcattatcc ggggctattg cgtttctgtt gccaatcggg ctgattgtat 1075921 ggtttaagcg aaagtatggt gcctcgctta aagtgttttt tattggcgct ctcacgtttt 1075981 ttgtcttcgc tcagctgctg gaaggcggcg ttcatgttta tgtactgcaa gtgaatgaaa 1076041 tgacgaaaga agcgatgcag catccattat ggtatggcat ttacggctgc ttgatggccg 1076101 gcatttttga ggagtgcgga aggtatttga tgatgcgatt ttttatgaag cgccatcata 1076161 cttgggcaga tggtctggct ttcggggcag gccatggcgg gcttgaagcc atcctgatta 1076221 caggcttgtc ctctatctca cttattgtat acgcatttgc aatcaatagc gggacgtttg 1076281 aacagctttt ggtcaatggc gacgtcaaac aggcgctttt gccgatacag gagcagctgc 1076341 tgcatactcc ttcgtatgaa tggatgctgg gcggaataga aagaatcagt gccattgccg 1076401 tccagattgg tctgtctctg cttgttttgt acgcggttaa aaaccgccgg ccgctgtttt 1076461 tgctgtattc tattctttta catgcactgt ttaatgtccc ggcggtttta tatcaaagag 1076521 gaatcataga gcatgctgca gctgttgaaa tcattgttgc tcttatagcg gctttatcag 1076581 tttattggat tgtaaaagca aaaagggtgt ttcaataaaa ggtccaagca gcagcaatgc 1076641 ccgcttggaa aaatgtgaat ggaaatattc attaagcatg ggtcatcaga atatttctga 1076701 ttcagtcttt agcaatgaca gcaagaatgt ctgtgttttt tacaagagaa acaatggtgt 1076761 ttctttttct tcttctcgca agggtcatgg cattctttct ttttcttgca atggtcgtgg 1076821 aaatctttat cgaaccactc gtcaaagaac caaaaatcat cgaaccaatc gtgacaacga 1076881 catttctgtt catgtgaatg acgacagcac atagaaatcc ctcctcttcc catgctctct 1076941 acagcatatg agagattgat aggaaaagat tggacgggtc cctcgggaaa agagtatatt 1077001 ttaagtagaa aataaaagga ggaatgccct atgacgtccg tacgtaaaac gatggagctc 1077061 attaaagaac ttgtatcgat cccaagcccg acaggaaata catatgaggt gatcaattat 1077121 attgaaagcc ttttaaaaga atggaaggta gaaacggttc ggaaccacaa gggcggctta 1077181 attgcaacgc ttccaggacg cgacacatcc cggcatcgca tgctgacagc gcacgttgac 1077241 accctcggcg ctatggtgaa ggaaattaaa gcggacggcc ggctgaaaat cgacttaatc 1077301 ggcgggttcc gctacaactc gattgagggg gagtattgcc aaattgaaac cgcctcggga 1077361 aaaatgtaca caggcacaat cttaatgcat caaacgtctg tgcacgtata caaagacgcg 1077421 ggaaaggctg agcggaatca agagaatatg gagatccgcc tagatgaacc tgttcactgc 1077481 cggaaagata cggaggagct tggcattggc gtcggagact ttgtgtcgtt tgatccacgt 1077541 gtcgagatca catcaagcgg atttattaaa tcgcgccatt tggatgacaa agcaagcgtc 1077601 gccttattgc tccgcttaat tcatgaaatt caaacagaag acattgagct gccgtataca 1077661 acccattttc ttatttccaa taatgaagaa atcggttacg gcgggaattc gaatattcct 1077721 cctgaaacag ttgaatattt ggcggttgat atgggcgcta tcggtgacgg gcaggcgacg 1077781 gatgaatatt cagtatcaat ctgtgtgaag gatgcgagcg ggccgtatca ttatcagctc 1077841 agaaagcatt tagttcaatt agccgagaag catcatattg actataagct tgatatatat 1077901 ccgtactacg ggtctgatgc gtcagcagcg atcaaatccg ggcatgatat tgtgcatggc 1077961 ctcatagggc cgggaattga cgcttcccat gcatttgaac gcacccataa atcatctctt 1078021 cgccataccg ctaagcttct gtattactat gtacagtcac caatggtata agggggagga 1078081 ccaatgaaga tttataagct gaaaagcaca ttcggttggg aaggtgatga cgggttggga 1078141 gaacagctga ttcagcagat ccttgccgga gaaaaaagcg ccacgtgcgc gccgaaatca 1078201 ttgtattcaa aagatgaatt gagggacgtt tatcaaacag cgggtcagct tgttaccgtt 1078261 tatgataaac atgacaatcc aagatgcaat ataaaagtaa cagatgtctt tgaaaccacc 1078321 tttggtgcgc ctgatatgag gttagtcaaa ggagagggca atggagaccg aattgaggag 1078381 tttcaagagg atcatcggat ggcatgggcg gaactgatca aaagcggtga actggagctg 1078441 aatgaggata ctgttttgat tacagagttg tttgtgcttg ttaaagatta aaaaagcctg 1078501 cggggcaaga accccgcagg cttttcatta accagaaatg gttgcgtttt gttctgtttt 1078561 cgattgggac ataacagttt ctgctttcgc aggattaaac atgccttccc atttagacat 1078621 cacaacggca gcaagcgcgt taccagtcag gttgacaact gtacgtgcca tatccatgat 1078681 gcggtctacg ccggcaataa aggcaagtcc ttcagccgga acgccgatgg tgccaagcgt 1078741 tgcaagcaag acaacaaaag aagtaccagg tacggcagcc atccctttgg atgtcaccat 1078801 taagacgagc acaagcgtaa tttggtgcca aatcgtcaaa tcaatgccat atacctgtgc 1078861 taaaaagagt gcggcaatag attgatagag aacggaaccg tctaagttaa acgtgtaacc 1078921 gatcggaatg acaaatgaaa caatgccttt tggacatccg attttctcca ttttttccat 1078981 gatacgcgga agaaccgttt cagagctgga cgtactgaac gccagtaaga tttcgtcctt 1079041 catgtaagca aggaacttga agatgctgat gccggcaatt tttgcgacaa tcccgaaaat 1079101 aacaattaag aagaaagcaa gcgcgacata aaccaatccg acgagctttc cgagagagat 1079161 aagagaaccg agtccgaatt tagacacagt cactccgata agagcgaaaa cgccgaatgg 1079221 cgccactttc atcacaaggt ttacaacgtg gaacatggca tgggatacac cttcaaaaaa 1079281 ggctaataca ggcttgcctc tttcaccgat cgcggaaata cccaatgcaa atagtactgt 1079341 aaagcagatg atggctagaa gatccccttc gaccaatgac tggaagaagt ttgtcggcac 1079401 aatatggagg aacgtttccg ccactgattt attactttgt tctttttcag tttcaacata 1079461 ttgactgatg tccgattttt gagcttcgtg tatattaact cctgtacccg gatggaagat 1079521 gtttgcaagg gctagtccga gaataatggc aaaagtcgtg atgatctcga agtacagaat 1079581 cgttctgaag cctaatttac cgacttgctt tccatttcct gcaccggcta caccgatgat 1079641 taagctggag acaacaatag gaatcactat cattttgatt aagcgtaaaa agagatcccc 1079701 gattggctgc aggtaagtag gcaatgctgg gttgccatac caaatgacgc caacaatgac 1079761 acctagaata agtccaacga atatttgtgt ggctaatcca aacttaattc ttttcataga 1079821 ttacctccca aaaaacaaag tatcaacata tatcatgaat agacatatat ttaatctcac 1079881 tattagatca aattataata gataagaaat caattcgtct atagtaaatt atatttcgaa 1079941 aataaagaat attcaatgac attatgataa tcaccagaat tatctaaaaa caggtgagct 1080001 ttgacctaac ctgactatta tttcaaaatt aagagatatg tgaaaaaata agaaaatccc 1080061 acgcgtaagg cgcgggattt tcgctcatta caaatcgttt acttttatac agtcattgca 1080121 gatattacca taacactcat gctgctcttc tatctttttt ccgcattccg cacacttttt 1080181 cgaaggcagg tttctaaaaa attctgtgat tttccccagc ataaccaatc cctctttccc 1080241 ctttgtagtg atttcattgt aatataacag attacaaaaa tcaataactg ttttgataca 1080301 atgtttaaaa catgcttttt tcaagaaaaa tgggtatatt gaaggaggac caattttttt 1080361 gaaaagatag gaggacatta tgaaagttac agttatcgga tgctatggcg gttttccggc 1080421 cgcaaatgaa gcgacgtcag gctatttgtt tcagtcaggt gattactctc tgcttgttga 1080481 ttgcggcagt gccgtattgt ctaagctgtt cggatatgtg ccggcggaaa agctggatgc 1080541 ggtcgttctg tctcattatc accatgacca tatcgctgat atcggaccgc tgcaatttgc 1080601 caagcaagtc ggttcgtttc tcggcaaagg agagcatacg cttccgattt acggacatga 1080661 tgctgatata gaacagtttc aaaagcttac atataaaaca catacaaaag ggatcgccta 1080721 tcagccggat cagccgctga ctgccggtcc gtttacgatc acctttttaa aaacgattca 1080781 cccggtgacg tgctatgcca tgcggattac tgacggcagc cacactgtcg tttatactgc 1080841 tgattccagc tatcaggatt catttatacc gttttcgaaa gatgctgatt tattgatctc 1080901 agaatgcaat ttttatgccg atcaagacgg aacaagtgca ggccatatga acagcctgga 1080961 agctgggcgc attgcaaaag aagccggagc gggagaactg ctgctgacac atttgccgca 1081021 ttttggcgtg catgacaacc ttcgcaaaga agcgaaaacc gtttttaacg gagaagtgaa 1081081 tattgcgaaa tcaggttttg tgtgggaagg ataaaggagg agcaccatgt tatttataga 1081141 caatcaaaat atcaatgatc cgcggatcaa tcttgctatc gaggagtact gtgtaaagca 1081201 tttagaccct gaacagcaat atttgctctt ttatgtgaat caaccgtcta ttatcattgg 1081261 gaaaaaccaa aatacaatag aagaaatcaa tacaaaatat gttgaggaaa acgggattat 1081321 cgtcgtccgc cgtttatcag gcgggggcgc tgtgtaccat gatctgggga acttgaactt 1081381 cagctttatt accaaggatg acggggacag ctttcataac tttaaaaaat tcactgagcc 1081441 agtgattcag gcgttacatc agcttggggt tgaagccgaa ttaagcggcc ggaacgacat 1081501 tgtagtagat ggccggaaaa tatccggaaa cgctcagttt gcaacgaaag gccgtatttt 1081561 cagccacggc accctcatgt ttgattcagc cattgatcat gttgtatcag cattaaaggt 1081621 gaaaaaggat aaaattgaat caaaaggcat caaatcgatc agaagccgag tggcaaacat 1081681 cagtgagttt ctcgatgata aaatgaccac cgaagaattc cgcagccatt tgcttcgcca 1081741 tatttttaac acaaacgacg ttggaaacgt gccggagtat aagctgacgg aaaaagattg 1081801 ggagaccatt catcaaattt cgaaagagcg ctatcagaat tgggattgga actacggccg 1081861 ctcaccaaaa tttaacctta atcattcgaa gcgttatccg gttggatcga tcgatttgca 1081921 cctggaagtc aagaaaggca aaatcgagga ctgcaaaatc ttcggagatt tcttcggtgt 1081981 cggtgatgta tctgaaattg aaaacctgct ggtcggaaaa caatacgaac gcagcgtcat 1082041 cgctgatgtg ctcgaaggtg tgaatctcaa gcattacttt gggaacatta cgaaagagga 1082101 tttccttgat ctgatttact aaggcaaaac acatcgtttg aaagagcggt tgtgtttttg 1082161 aaataatgga ggcaggaggg attcacatga aagtgttttt aatcggagcg aacggacaaa 1082221 tcgggcaaag actcgtctct ttattccaag ataatcctga tcattccatc agagcgatgg 1082281 tcagaaaaga agaacagaaa gcgtctcttg aagctgccgg tgcagaagct gtgcttgcga 1082341 atctggaggg cagcccggaa gaaatcgccg ctgcggcaaa aggttgtgac gcgatcattt 1082401 tcacagccgg ttccggcggc agcacaggct atgataaaac gctgctggtg gatcttgatg 1082461 gagcggcaaa agccattgaa gctgcggcca ttgccggaat caaacggttt attatggtca 1082521 gcgccctgca agcccataac cgtgaaaatt ggaatgaggc actcaagcct tattatgtgg 1082581 ccaagcatta tgctgataaa attctggaag cgagcggttt aacctatacg attatccgtc 1082641 cgggaggcct tcgcaatgag cctggaacgg gaactgtttc agcagcgaag gatctggagc 1082701 ggggatttat ttcccgtgat gacgttgcaa aaacggtcat tgcctcttta gatgagaaga 1082761 atacggaaaa tcgggccttt gatctgacag aaggagatac gccgattgcc gaagcattga 1082821 agaaactatg acagtactga cactcagggc tttttgctct tgagtgtttt tttctgtttc 1082881 tctataatgg agaagaaagc ttggcttcaa taatgaatga ctattcattc acttaagggg 1082941 tgggagaatg aatcttgttt caaaattgga agaaacagca tctgagaagc ccgacagcat 1083001 cgcatgcagg tttaaagatc acatgatgac gtatcaagag ctgaatgaat atattcagcg 1083061 atttgcggac ggccttcagg aagccggtat ggagaaaggg gaccatttag ctttgctgct 1083121 tggcaattcg cctgatttta tcatcgcgtt ttttggcgct ttaaaagctg ggatcgtagt 1083181 tgttcccatc aatccgttgt acacgccgac agaaattggt tatatgctga caaatggcga 1083241 tgtaaaggca atcgtgggcg ttagccagct tttgccgctt tatgagagca tgcatgaatc 1083301 gctgccaaag gttgagctcg tcattttatg ccagacgggg gaggccgagc cggaagctgc 1083361 ggacccagag gtcaggatga aaatgacaac gtttgcaaaa atattgcggc cgacatctgc 1083421 cgctaaacaa aaccaagaac ctgtacctga tgataccgcg gttattttat atacgtcagg 1083481 aacgactgga aaaccgaaag gcgcgatgct gacacatcag aatttgtaca gcaatgccaa 1083541 cgatgtcgca ggctatttgg gaatggatga gagggacaat gtggtctgcg ctcttcccat 1083601 gtttcacgtg ttttgtttaa ccgtctgtat gaatgcaccg ctgatgagcg gcgcaactgt 1083661 attgattgag cctcaattca gtccggcatc tgtttttaag cttgttaagc agcagcaggc 1083721 gaccattttt gccggtgtgc ctacaatgta taactacttg tttcagcatg aaaacggaaa 1083781 gaaagatgat ttttcttcga tccggctgtg catttcggga ggcgcgtcca tgccagtcgc 1083841 gttgctgacg gcgtttgaag aaaaattcgg tgttaccatt ttggaaggct acgggctctc 1083901 ggaagcatca cccgtcacgt gctttaaccc gtttgacagg ggcagaaagc cgggctccat 1083961 cgggacaagt atcttacatg tcgaaaacaa ggtcgtagat ccgctcggac gcgagctgcc 1084021 cgctcaccag gtcggcgaat tgatcgtgaa aggccccaat gtgatgaagg gctattataa 1084081 aatgccgatg gaaacagagc atgcattaaa agacgggtgg ctttatacgg gggacttggc 1084141 aagacgggat gaggacggct atttttacat tgttgaccgg aaaaaagaca tgatcattgt 1084201 aggaggatac aatgtgtatc cgcgggaggt ggaggaggtg ctgtacagcc atccggacgt 1084261 caaggaggcg gttgtcatcg gcgtgccgga cccccaaagc ggggaagcgg taaagggata 1084321 tgtggtgccg aaacgctctg gggtaacaga ggaggacatc atgcagcact gcgaaaagca 1084381 tctggcaaaa tacaagcggc ctgccgccat tacgtttctt gacgatattc cgaaaaatgc 1084441 gacggggaaa atgctcagac gggcactgag agatattttg ccccaataaa atgaaaaagc 1084501 gaagcggtta gcttcgcttt ttcattttca atcctttgct tcttttttaa taatatttag 1084561 cagcgccttt gtatcatttt tgcttaattt gtagtatgtg ccatccttca aaaaaacggc 1084621 ttgctggctg ccgtcaatcc atagtctgaa tgagtcatac cggtctttat gaaacttgat 1084681 tgtcccttcg taatcagggg ctgatgtttt ttctgtcttc acctgttttc cctgattcat 1084741 aatatccagc atatctttga cgtgctgtct tttttcaatc tcgatatctt cctggccgct 1084801 tgaagacagt gtgatcaaat ccgcgtctac cgattgatac acatcgcctg atcggctgta 1084861 aagataaaaa aatgcgataa acacaagacc gattaccacg atggctgcca ctattttttt 1084921 catttgcatc actccaaaca ttgttagttt tcccagcgat cggggtttcc atgcttaaaa 1084981 gggtggaaaa gtgcggaaca cagcttggtt ctaagaattt gaatttatga ttacaataga 1085041 agtaacgggt tgatgtgagg agtgaggcgt tatgcgcaag tggattgcgg cagcaggact 1085101 tgcttacgtg ctgtacgggc tgttttttta ttggtatttt ttcctgtcgg gtgattccgc 1085161 aataccggaa gccgtgaaag ggacgcaggc tgatccggct tctttcatga agccgtctga 1085221 gttggcagtg gccgagcagt attcgaatgt caagaatttt ttatttttta tcggggtacc 1085281 acttgattgg tttctgtttt ttgttctgct tgtcagcggt gtttcaaaga aaatcaagaa 1085341 atggatcgaa gcggccgtgc cttttcggtt tttgcagacc gttggttttg tgtttgtgct 1085401 ttcgctgatt acaacattgg tgacgctgcc tttagattgg ataggctatc aagtatcgct 1085461 tgactataac atttccacac agacaacggc cagctgggct aaggatcagg ttatcagctt 1085521 ttggatcagc tttccaatct ttacgctttg cgttctcgtt ttttattggc tgatcaaaag 1085581 gcatgaaaaa aaatggtggt tatacgcctg gctgttaaca gtgccgtttt cgctgtttct 1085641 gttttttatt cagccggtca ttatcgatcc tttatacaat gatttttatc cgctgaaaaa 1085701 caaagagctt gaaagcaaaa ttttagagct ggcagatgaa gccaatattc cggctgacca 1085761 tgtatatgaa gtgaacatgt cagaaaaaac aaatgcgctg aatgcctatg ttacaggaat 1085821 tggggccaat aaacggattg tattgtggga tacgacgctg aacaaacttg acgattcaga 1085881 aattctgttt attatgggcc acgaaatggg ccattatgtc atgaagcacg tttacatcgg 1085941 tctggctggc tatttgctcg tgtcgctcgc cggattttat gtcattgata agctttacaa 1086001 gcggacggtt cgcctaaccc gcagcatgtt tcatttagaa gggcggcatg atcttgcggc 1086061 acttccgctg ttattgcttt tgttttctgt tttgagcttt gcggttacgc ctttttctaa 1086121 tgctgtctcg cgttatcagg agaataaggc tgaccagtat gggatcgagt tgacagagaa 1086181 cagagaagcc gctgttaaaa cgtttcagga tttggccgtg acggggctga gccaggttga 1086241 tcctccggtg cttgtgaaga ttttcagagg cagccatccg tcgatcatgg aacggattca 1086301 acatgcggag aaagaagaga atgcgccgga acatcaggat gctgacaaat aaaaagaagc 1086361 aggtatggag gaacctgctt ctttttacta ttattgtgca gctgcttgta cgttgattaa 1086421 cccttttcca tagtagaaag agtttccaag atatgttgca gtgctttcta aacgatcacg 1086481 gacttgcgcg tttgtccaag tcgggtgctt agaaagaatt aacgctgctg ctccggcaac 1086541 gtgaggagtc gccatggacg ttccgttata agcgccgtaa gtgcctccag gaagtgtgct 1086601 ttggatggac acgccaggag ccatcacatc aagctcagaa cctgcgctgg agaatgaagc 1086661 tctttggttg ctgctgttta ccgcacctac tgcaatagta gaaggatatt ttgcagggta 1086721 gccgactgtg cttgtgcttc cggatgaacc ttcgtttccg gctgcggcag caacgacgat 1086781 accgctggaa acggctttgt caacgactgt tttcagcgct gtagaaccag taggtccgcc 1086841 aaggctcatg ttgataacat ccatattgtt ggaaatggcc cactcaatgc cgttaataat 1086901 ccagctatat tggccgcttc ctgttgaatc aagcactttt actgcatata atgatgcgct 1086961 tggcgctacg cccagaacac cgattgagtt attaagagcg gcaatcgtac cggctacatg 1087021 cgtaccgtga gaactgccgt cctggtatgg gtttgtttca gaaggtacga agcttgctcc 1087081 gcctctgacg tttaagtcag gatgagaaga gtcaattccg ctgtcgataa cagctacttt 1087141 tacgttagag cctgtgtagc cttgagagtg aagagccggc gctttaattt gagaaatgcc 1087201 ataaggaaca gattgcgcat attcatgtgc aatatgatct tcttccacat atgcaacgct 1087261 cggatctttt ttcaattctt ttacagcttt ttcatccaat gttgctgcgg ccgcgttaac 1087321 atacttaaat tgcttttgaa cctttccgcc tttttcagaa ataacatcct ttttcttggc 1087381 ggaactcatg gcactcattg tctgtttaaa tccgacaatg tatttctttt ctgtactgct 1087441 ttttccggca gcctgcgcag acatgttgct gaacgccatc gtaaagatta acgttaacgc 1087501 aaacaacaag ctgatccaca attttttgct tctcactctt taccctctcc ttttaaaaaa 1087561 attcagagta gacttactta aaagactatt ctgtgaattt attgtaatag atggaataat 1087621 attttagtag acccattttt ttgagatgat tttatctcta tttaggtata tcatctctcg 1087681 ctatttccgt agagactcga aataactatt ttcatacaga aaagaacgaa aatagacatg 1087741 agtaaatgtt cattatgctg aaatgtcatg cttttttagg ttaaatgctc ctgagtcccg 1087801 gcaaattcct gtcgaaaaaa ttcgttcaaa tgacctgcgt gtgcttccgt gagaacaatg 1087861 gatattatcg tgatattttt tcaaagcatg atgataaaag tattctgaaa aataaacttt 1087921 acagaaaagg gatagaatga aaaaattatt gagagggagg aagaaataag atgaacattc 1087981 gccaagcaaa gacatcagat gcggccgcca ttgcgccgct gtttaaccaa tatcgggaat 1088041 tttatagaca ggcatccgat ttgcaagggg cagaggcttt tttgaaagct cgtttggaaa 1088101 atcacgagtc tgttattttg atagcagaag aaaatggaga attcataggc tttacccagc 1088161 tctatccaac gttttcttct gtgtcaatga aaaggatata catattaaat gacttatttg 1088221 tcgttcctca tgcgcgtaca aagggagccg gcggccggct gctttctgcc gcaaaggatt 1088281 atgcagggca aaacggggca aaatgtttaa cacttcagac tgagcaccac aaccggaagg 1088341 caagaagctt gtatgagcaa aacggctatg aagaggatac cggatttgtc cattattgtc 1088401 tcaatgtgcc ggcgaagtga aaatggcggc ttgatgattt ggttttttga acgttcttcg 1088461 gttacgatat aaatgaaaag gagtgtgccg aatgtcaacg ttatttcaag ccttgcaggc 1088521 agaaaaaaat gccgatgatg tttcagtcca tgtgaaaacc atatcaacag aggatttgcc 1088581 gaaggatggt gtcctgatta aagttgctta ttccggcatt aattacaaag atggtctggc 1088641 cggaaaagca ggaggcaata tcgtcagaga gtatccgctt attttaggca ttgatgctgc 1088701 gggtacggtc gtctcttcca atgatccgcg ttttgcggag ggggatgagg tgatcgcgac 1088761 aagctatgag ctcggtgtct cacgtgatgg cggattaagt gaatacgctt cggtgcctgg 1088821 tgactggctg gtgcctttgc cacagaatct ttcgttaaaa gaagcgatgg tgtacggaac 1088881 ggcgggattt actgcggcgt tatcagtgca tcggcttgaa cagaacggtc tgtctccgga 1088941 aaaaggcagc gtgctagtca caggagcaac cggcggtgtc ggcggaattg cggtatcgat 1089001 gctgaacaag cggggttatg atgtggtggc aagtaccgga aaccgggagg cggctgatta 1089061 tttgaaacag cttggtgcaa gcgaagtaat cagcagggaa gatgtctatg acggaacgct 1089121 taaggcgctg tccaagcagc aatggcaggg agcggttgat ccagtcggcg gaaaacagct 1089181 tgcctcgctt ttaagcaaaa ttcaatacgg cggatctgtc gcagtgagcg gcttaaccgg 1089241 cggaggagaa gttccggcaa ccgtgtatcc ttttattctt cgcggagtaa gcctgctcgg 1089301 aatcgattca gtatattgtc cgatggacgt cagagccgct gtttgggagc gcatgtcttc 1089361 tgatctcaag cctgatcagc tgctgaccat cgtggacagg gaagtatcat tggaagaaac 1089421 gccgggtgcg ttaaaagata ttttgcaaaa tcgcattcaa ggaagagtga ttgtgaagct 1089481 ttaacaggat cagcttgcag agaatgttat ttttctgcaa gcttttttgt ggacaggatg 1089541 atcagctgct gaactgctgt gtcgcgaaac aagattttcc tgtaagccga actttctctt 1089601 ctcattttaa aaataattgg tgataatgat tctcattccg tgttatacta ctcttggaca 1089661 tcttaaccat agaaactacc aacaggagag actggaacat atgaaaaaaa cactgattat 1089721 tcttacagtt ttacttcttt ctgtcttaac ggctgcttgc tcgtcttcaa gcggcaatca 1089781 aaacagtaaa gaacataaag tggcggtaac acatgattta gggaagacaa atgtgcctga 1089841 gcatccgaag cgggttgttg ttcttgagct aggttttatt gatacactgc ttgatctcgg 1089901 cattacgcct gtcggggttg ccgatgacaa caaagcgaag cagctgatca acaaggatgt 1089961 gctgaagaaa attgacggct acacatctgt cggcactcgc tcacagccaa gcatggaaaa 1090021 aatcgcttca ttaaaacccg atttaattat tgctgacacg acccggcata agaaggtgta 1090081 cgatcagctg aaaaaaatag cgccgacgat tgcacttaat aatttaaatg ctgattatca 1090141 ggatacaatt gacgcttcgc ttacgattgc aaaagcagtc ggcaaggaga aggaaatgga 1090201 gaaaaagctg acggcgcatg aagaaaagct tagcgagaca aagcagaaaa tcagcgcgaa 1090261 cagccagtcc gtgcttttga tcggaaatac aaatgatacc attatggcca gggatgaaaa 1090321 cttctttaca tcgagacttt taacacaggt cggctaccga tatgcaatca gtacgtcagg 1090381 caatagcgat tcaagcaatg gcggcgactc tgtgaatatg aaaatgacac tggagcagct 1090441 gctgaaaaca gatccggatg tgatcatcct gatgacagga aaaacagatg acctcgacgc 1090501 cgacggtaaa cgcccgatcg aaaagaatgt cctttggaaa aaactgaagg cagtgaaaaa 1090561 cgggcatgta taccacgtgg atcgtgcggt gtggtctctg cgccgcagtg tagacggggc 1090621 gaatgccatt ttggacgagc ttcaaaaaga gatgccggct gctaagaaat aaaagaaaag 1090681 acaggcaaac gcctgtcttt ttcttatttg ataaagccgg ataagtggct gttgatatta 1090741 tagtctttta tccgccattt ttcttctgca aattcaatgt tgctgaggca ggcgttgacg 1090801 agacgggtgc tttgaagctc cgggtcaccg ccggatattt ctgtcagcag ggcgtgaatt 1090861 gccgcaccgt gcgccacgat cagcaccttc ttgtttggat acgcctgatt cacttttgcc 1090921 aaaccgccca tcagcctgtc agtgagttct tctaaggttt ccatattcgg atagatgtta 1090981 tctggatagc gctttgtccg ttcctccagc ggcatgccct ccgcgtcgcc gtaatcgcgt 1091041 tccttaaaat catccatctc gactatcgga agatgcagat attcattaat aatttccgcg 1091101 gttcttttcg ctcttttcag cgggctcgtc acaataatat cccaagaaaa gtcctttaca 1091161 tattctccgg tttctcttgc ttggcgttca cctgttgcgt ttagcgggat atcggttttg 1091221 ccttggcatt tttgctgcag gttccaatcg gtttctccat gtcttactaa acaaacggct 1091281 gtcataaaat ccccttcctg actttattca tatcgctatt atactaaatc gaaagcgtgt 1091341 gtcctatgaa aaagcctatg caagaacttc aaataataaa gccagtccga ttccgccgcc 1091401 gcttccgatg gctgcaacag catattgaca gtctggccgt cttttcgctt cataaaacaa 1091461 tctggttacc agagctgcac ctgatgcacc gtacggatgg ccaagagcta aggcgccgcc 1091521 gcgcacattg atttttgaaa agggaatgcc gagttcttgc gagcagacac aaattttgac 1091581 ggcaaaggct tcattgattt caaataaatc gatatcatca ggtgttacat cgtgtgtatg 1091641 taagagctga cgaatcgcga caaccggtgc cgcgggcgga aagttggggt gaatgccgct 1091701 gacagcgctg ccgataaacc gaagcacagg cttaagtccc agggctgctg ctttttcttc 1091761 ttccattacc aaaagagcgg ctgctccgtc tgctatgcca ctgctgttgg ctgctgtgac 1091821 tgttccggag ctggtgtcga aaaccggctt tgcacgggga ataatcgctt ctattggccg 1091881 cgttttcaaa aatgcttcgt ccgtctccaa ttccccgaga gcaacaactt cttcacggta 1091941 aaatccttca tcatgcgcgt tcctgctgcg ttgatggctg agaagcgcgt actcatcctg 1092001 catgcttctg ctgatggaat agcgtgcagc cgtatattct gccgcaatgc ccatgtctgg 1092061 atcgccgatc gcatctggag aaaagcgagc ccgttctgaa aaaggggatt ggctgctgct 1092121 ttctgagccg cccgcgatat acatcgtgcc ggctcccgct tgaataaggc tgcaggcata 1092181 gcgcacagct tcaaggccgg agccgcactg tctgtcaatt gtcattccgg gaaccgataa 1092241 aggcagtccg gcttgaaggg ctgacagtct ggccaggttg ccgcctctgc cagtagcgtt 1092301 tccgagaatg acctcgtcaa cttgatcctc tagctttcgg ctgagacagc ggatgatggg 1092361 agccgccaaa tcctccggca ggaagggctt cagcagtccg ttttgatttc caaagatcgt 1092421 tcgttttgca tcaacaataa ccgcattcat ttatactgta cactctcttc cagccatttt 1092481 ttcactctgg aacgggcaat ttttccgctg ctcgtttccg gcaagctgtc tgcaaacacc 1092541 cattttttcg gaattttata ggaggctaat ttctgtttac accaggcttt cagtgttctg 1092601 gcattagcgt ttccaagaat gacagctaca gcgatttctc cccaatactc gtcgggaatg 1092661 ccaacgacag ccgcgctttc aacctctggg caggcgagaa gcacacgttc aatttcttct 1092721 gggaaaatat ttaatcctcc gtacacgatc atcccgtttt ctcttcctga tatgtataga 1092781 aagccctctt catcaacgta gcccatatca tctactgtca tccattcatc tggtgtgctg 1092841 ccgttcacat agccggaaaa cctcatcggg cttttgacaa atatttttcc gatttctcct 1092901 ggctggcagc gttctcctcc agcgttgcgg atttcgatcc ggacattatg aaaagggcgg 1092961 cccgctgaat gcggcttccg tttgctgtct tccggtgaag aaaacgtcac aaaactaagc 1093021 tctgatgtgc cgtaaaaatc gtacagcttg agatgaggcc atgcagcggc aagcttcttc 1093081 ttggattctg ccggccagtc tgcgccggat gaaatgattt tgacgggact gtcgggaaaa 1093141 ccctcaatcc ttgcgagggc gtctgtcatc gtcggtacgg tatagagaac actgatggat 1093201 tcacggcaca gccattcctt cgctttggca ggagaaaact ttttcagcaa acaaacggtt 1093261 cctccgagaa acaaagtgct gacagcccca tataggaagt gagaggacat taacgctccg 1093321 ggaatcagaa ccttatcatc tgatgaaatc gaaaaatctg tttctgtaca ggtaaagctc 1093381 tccatccatg agcggtgaga tcgcgtaaag gccttcggtt ttcctgtcga gcccgacgta 1093441 aatcccatat aaaaagggtg ctccggatca atggtaggca agggatcagc ggctgcctca 1093501 gaaatatctg ccatacagtt atccagcaat acaacaggtg tctggctatc tgtcagtttg 1093561 tttttgaaaa aggctaaagt aaccacaaga tccgcattgc ttatggacag ccgctcctta 1093621 cattcagccg ggctccagcg tgtgtcgatg ggaatggccg tacatccagc cgctgcggct 1093681 ccggcaaaca gctgtaaaaa cgcgagacta tttgggagca ggatcgccac acgattcggc 1093741 atgctcggct gtgaccgcag ccaatttgcg gtttgagaga caagccgatc ccaatcatgg 1093801 tacgtgattt gctccgattc agtctggatc gctacacggc cgggcgatgt ttcggcagta 1093861 gatgaatagg tatgagtaat tgtcatgtat tgtcatcctc cttttgtaaa catcgtatca 1093921 gaaagagaca aggcttgagt gatttttatc gccagaaatg cagatacagc cgcttttatc 1093981 aaatcaccag gcacatatgc aaggctcatg aaggcggcct gtgacaaatc aatatgcatg 1094041 ataaaagctt gtaccggtat accaagcaga taaataaaga tgatgccgaa tacgatatga 1094101 gtgaaaaaga gacgcaatac tgtcaccttc cgcagcctgt tagcggctaa actgatcagc 1094161 catgaagcga ggggataagc aatcaaaaag cctgcgctcg gtccgaaaaa cacaccaaaa 1094221 ccgcctcgtc cgccgggcaa cagcggcgct ccgaaggcga cgagcagcaa aaagacaagc 1094281 tggcttaaga aagcagactt tggcctgaga atgctgcctg ccaacatgac accaagcgtt 1094341 tgcaatgtaa tcggaacggg tgtaaaggat aagaagagag ggggcataaa gccgagcact 1094401 gccatcagcg cggtgaaaat cgcaatatgc atcatgtcga ttaatttcag catgtgaaat 1094461 cctccaaaaa gtaatcaaat atggttatac aataaatgca ggtaattatt atgtcaactg 1094521 atttttaatt taagtttaca taatgaacgc aaaaaaaccg gccgtatggc agaccggttt 1094581 ttgatggtta ttcttctgtc aggatgacaa gcgaatcaac ggaagcggcc acatgggaaa 1094641 cggcgcggct gacttcctga agccctccaa gaaaggcttg cagatcgacg tcgattttgc 1094701 ctgattgctc tttgctgatt ttcatgctgt ggacgatttc atcgaataag cggttaattt 1094761 gcgtcatttt ttctttactt tcgctgacta gctcattcac gtctttgata tgcttggata 1094821 caatgttgat ttgtgtattc gtattgttca caagctcaga aacagtagag acggtttttt 1094881 tcgtatcctc agaaagcttc cgcacttcat ttgccacgac agcaaagcct ttgccgtgtt 1094941 ctccggcgcg ggcggattca atagatgcat tgagcgagag aaggtttgtt tgttcagcta 1095001 tgcctgtgac gatgccgaag attttttcaa tttgctgcgc gatttcatcc agcttgacca 1095061 tttctttttc gatttggaca aggcttgtgt caattttgtt catctgtttt tgctggactt 1095121 ctagctcttt ttttccgccg atcgactttt cttcaacagt gctggatgtt acagtgccgg 1095181 ctttggatgc ttgagaaatg ccttcagatt tgtccacaag ctcttgaact gatctgcttg 1095241 tttctgaaaa cagattggca atcgatccag aggtttcttg aattttctga tgaagaaggt 1095301 ttttcttttc ttcttgttca tcacgggtct ggttgtactc gctttgaaac gcttcaagga 1095361 caagctgctg ttctaagttc aagatttttg ttgttgcttt aatggctttt agcagttctt 1095421 gctgatttgt aatggacgct tcataaatgt caatcattga caaaaggagc tcttgaaacg 1095481 cacccatata ccattttggc aaaaggccga ttcttaaatg gatggaggcg attcggttac 1095541 gcttttcaat aaattcatca tcgataacgc ctgcaaacat ttcctgaata tgccgtttta 1095601 acgtttgttt taagcggtca actgagctgt gatcattaat gatatccatc aatgagcttt 1095661 catggtcaag gtttttataa aacgcatcga cgatatttac gatattttct tgaatgagtg 1095721 gctgaagctg ctctaacaca taaagctcag catctcccaa cctgaccatt ttgagctgtt 1095781 ttttgacatc tgcatgtttg tttgtgagct gaatgcggtt tttttgttgt ccgtttgaat 1095841 ctgaaaagta agctgtttct tgttttctgt cttttttaaa taacaataca atgatccccc 1095901 ttgggaaaaa tataattttt actttttggc tttttaagcc tttttctttt ttatcggcca 1095961 agggaaacat gaatgaagct gcagatgaaa aatatttgaa aaaacgttca ttaaaatgaa 1096021 cggtttaatc gagatctatt tgttttaatg gtttaatggc cggaccctct acaacttcgc 1096081 cagatggctt aaagcgtgat ccgtggcacg gacaatccca cgtatgctca ctgtcgttcc 1096141 actcgacctc gcagcctaaa tgggtacaag tcgtatcaac gagatggagg cagcctgtct 1096201 catcacgaaa tgctcccgct cgcctgccgt ttatggtgac ggctttccct tctcctggcg 1096261 aaatgtcttc aaattggaca tcaggctttt caagctttcc ttttatcaaa tgcttggcga 1096321 catctgcatt gtaggaaatc actttctgca acccgggatt cagatggaaa cgggacggcg 1096381 tgaaaatgct ttcgtatggg ttttcttttt tctccacaag gtctgacaat aaagtggctg 1096441 cgactgctga ggacgtcatg ccccattttt tgaacccggt cgctactaga atattgtcct 1096501 cattttccga catcggcccg ataaacggga ttttgtcgat cgtcactaga tcttgggtgg 1096561 accaataata tggaatgctt tcgatgccga tggtgctttc ggccagttgt ctcagtgttt 1096621 cataatgtgt agacatggct tttccctggc ctgttttatg gcttactccg ctgaagagaa 1096681 tcagcttttc accgtttaca accgtatagc ggagcgccac tgacggctga tcgatactca 1096741 aatacatgcc ctcgggatac tcgatcttcg gcttgatggc aaggacataa gatctgtcgg 1096801 agtacattct cgcagcatat aatccgcctc cgtcataaaa agggaagtgg gaacagcata 1096861 tgataaagcg gctcttaatg gcgtgccggc tttttgttac cacttcgggc ctttcgcctt 1096921 ttttgatatc aagcgcaacg gtctcttcat aaattcggcc gcctttttga acaatttgct 1096981 ccagaagcgc ttttaagtat tgaagcggat gaaattgagc ttgattcttc atgacaagcg 1097041 ccagcttaga acctaaggga attggaagat ccttgataag gtctctttca attccgagct 1097101 ttgtgtatgc ctcatgctcg gtgtggattt tttgaacagc gttttcattt gccgtataaa 1097161 gatatgcgtc ttgctcgatc cattcacaat caatttgatg ttcatccaca atgcctttta 1097221 tgtaatcaat tgcgttttgg tttgcttcat aataaagcct cgcatggttt aatccgaaat 1097281 ggcggataaa ttcgtcgtat atcatgtcat gctgtgcggt aactttagca gttgtatgcg 1097341 cagtggttcc gttaagaacc tgatttgctt caatcaaaac gacacggaag cctctcttcg 1097401 taagttcata tgccgttgtg attcccgtaa tcccgcctcc gataatggtg acgtcacatt 1097461 cagtgtcctc ttgaagcgca ggaaaagaag gcaggtcagt tgatgttttc cagtatgttt 1097521 caggtgcttc ctttgcaaaa tgttgattag ccaagccgtt atacctccaa tcagatttat 1097581 tcttaatttt tccatattct atcttttcat acataggaag caggcattgt tcataacata 1097641 ataaggttga aaaggagtga tttcattggc gaatcaaaaa aagaaaacat taccgcctca 1097701 gcaccagaac cagcagcctg gttttgaata tctgatggac ccgcgtccgg tttttgataa 1097761 gccgaagaaa gcgaaaaaat tagagggcaa aaccgctatt attactggag gagacagcgg 1097821 gattggacgc gctgtctcgg tgttattcgc aaaagaaggg gctaatgtgg tcattgtgta 1097881 tttgaatgaa catcaggacg ccgaggaaac aaagcagtat gtagaaaagg aaggggtaaa 1097941 atgcctgctg attgcaggag atgtcgggga tgaagcgttt tgcaatgatg tggtcgggca 1098001 ggcaagccaa gtgtttccat ccattgatat attggttaac aatgcagctg agcagcatgt 1098061 ccagcccagc attgaaaaaa tcaccagcca ccagctgatc agaaccttcc aaacaaacat 1098121 tttttccatg ttttacttaa caaaggcagt gctgcctcat ttaaaaaaag ggagctctat 1098181 tattaatacc gcttcaatta ccgcctataa aggcaataaa acgctgatcg attattcagc 1098241 gacaaaaggc gcgatcgtta cgtttacaag gtccctttcc cagtcgcttg ttcagcaggg 1098301 catacgggtc aatgcagtgg caccgggtcc catttggaca ccgcttatcc cggccagctt 1098361 tgccgcaaaa gacgtggaag tgtttggttc agacgtgccg atggaacgcc cggggcagcc 1098421 ggtcgaagtg gcgccaagct atctatacct tgccagcgac gattccacat acgtcacagg 1098481 gcagacgatt cacgtcaatg gcggaacaat tgtgaacgga taataaaaag ccaatccttg 1098541 aaggattggc ttattcgctc tgcttgagcg ctgcatattc tttagagagc gtaagaaacg 1098601 catctttatc tttttcgtcc aaggctttgt taatttggtc cgtcagcatg gcaagccgac 1098661 ggttatacaa ggattcatcg agcaccattt gaatgtaaat atccgtcatt gtgacatcga 1098721 attcttttgt tttttgcgtg ttgcgggact tcatgagctc agtgtacgat tttttctctt 1098781 tcataaagaa tccccccaat gcctttttta tagtatatgg ataacggtcg aaaaaatcaa 1098841 taaattttta taatttttag acaactaata cttggcaatc tatcgacata tcctgcaaaa 1098901 tgccgtaaac cggcaagtct tatgaaagta aaatcggttt attactagtc atttagtacc 1098961 attaaatatc attaaaagat gattttatct taaatgttaa aaaaacctgt cgttttacaa 1099021 aaacagatga tagattatta gtataaattt tgcagaaaaa ggatggaggc cataatatga 1099081 gtcagaaaac agacgcacct ttagaatcgt atgaagtgaa cggcgcaaca attgccgtgc 1099141 tgccagaaga aatagacggc aaaatctgtt ccaaaattat tgaaaaagat tgcgtgtttt 1099201 atgtaaacat gaagccgctg caaattgtcg acagaagctg ccgatttttt ggatcaagct 1099261 atgcgggaag aaaagcagga acttatgaag tgacaaaaat ttcacacaag ccgccgatca 1099321 tggtggaccc ttcgaaccaa atctttttat tccctacact ttcttcgaca agaccccaat 1099381 gcggctggat ttcccatgtg catgtaaaag aattcaaagc gactgaattc gacgatacgg 1099441 aagtgacgtt ttccaatggg aaaacgatgg agctgccgat ctcttataat tcgttcgaga 1099501 accaggtata ccgaacagcg tggctcagaa ccaaattcca agacagaatc gaccaccgcg 1099561 tgccgaaaag acaggaattt atgctgtacc cgaaagaaga gcggacgaag atgatttatg 1099621 attttatttt gcgtgagctc ggggaacggt attagaaaaa taggaaggag ctgaccgaac 1099681 agggcagctc ctttcataaa gctatgccgt cggaattcct ccggtgatgc catatacctg 1099741 agatgtcaca tagcttgaat tctctgaagc tagaaataca taaacatcgg ccaattccac 1099801 tggctgccca gcgcgattta atggagctgg cggcgtgcct tgtccgaatt tcgggatgtt 1099861 ttccgtcggc tgtccgccgg aaatttgcag cggtgtccaa attggtccgg gcgcaactga 1099921 atttactctg atgcctttgg aagcaagctg ttttcccagt ccgacggtaa agccgataat 1099981 ggcgtttttc gttgctgcgt aatctaacag catcgggctt ggattatagc cttcaactga 1100041 ggtagttgtg ataattgaag ctccctccgg caaatacgga agcgccgctt ttacaaccca 1100101 gtaaagggaa aagacgttca cttcaaatgt tttatagatt tgttcagtag gcagatcttc 1100161 gatgttttcg accgcttgct gtttgcctgc aacgagcgct agcacatcaa gtccgccgag 1100221 ttcgtgatgc gactgtttga ctagatcttg gcaaaaggat tcgtcgctca agtctccggg 1100281 gatcagcact gcttttcggc cttctgcttc aatcagctct tttacctctt cagcatctgg 1100341 ctgttcctcg ggcaagtagt taatagccac atcggcacct tctctggcgt aagcaattgc 1100401 ggcagcgcgg ccgataccgg aatcgccgcc cgtgacaagc gcttttcgac ccgttagttt 1100461 acctgatcct ttgtagcttt tttctccgca atcagggaca ggcttcatgt tcttttgcag 1100521 gcctggcggt tcttgatatt gttcgggaaa ttcatcatga aaaaatgctt ttataggatt 1100581 cgtaagattt gaatcagaca tcagcaacgc tccttttctg tttggtgtac attcgtatgt 1100641 gtacccctga gcataagcag aaaaacatgt tttggcagtt tgaatagtga aggaaaaaga 1100701 aaacaagaaa aaacaaagcc ttcttccata tttatcttgt caaataagac tatatgaatt 1100761 atgataaatt cgagctataa atcaactaaa tattgggtgt tgggagagtg aatcgtcatg 1100821 aaaaaagcgg cggcggtttt gctgtcactc ggtctcgttt tcggtttttc atacggagct 1100881 ggccatgtgg cggaagccaa aacaaaggtg aaggtctata agaactgcaa ggagctaaac 1100941 aaagtataca aaggcggagt ggcccgcaca tcgaaggtga aaaacaaagg cggaaaaacg 1101001 aagtacaagc cttacgtttc taaggcactt tacgatgcca ataaaaacaa agaccgcgat 1101061 aaagatctta tcgcctgtga acggtaaata agaaaaagca atctggtgtc cagattgctt 1101121 tttttatgct taggccgcct gatcggccgc agcgcttttc gccttccttg tcataaggct 1101181 gactgccatc atgaccgtga tattcaaaag cagggcgacg atgccgacat tcaagtcttt 1101241 tgcggcttgc ggcagagccg gaaataaagt gccgatcgtc gtttccgtca ttgtaatata 1101301 agtaactgct ccgacacctg caataatgcc ggcgaaagct ccttgctttg tcaccatatt 1101361 atgcttgagc aggctgaaca aaagggcggg gaatagctgt gtgacaaggc tgtagcccat 1101421 caaaagcagc gtaacgatgg tattcccgcc tttgaaggta aaatacaccg aaatcagcgc 1101481 aatcaccggc actaaaaact tagcaagcgc cgatacttgc tgttctgtcg tgcggggcgc 1101541 gattaccttg tacacatttt ttgcaaacag tgtggaggcg gacattaaga tcatagaccc 1101601 tggcacaagt gctgtcagca gtccggcagc accgataatt ccgacaaacc aagggtcaaa 1101661 tgcttgcaga gacagtctca aaagcgacaa atccccgtct gcgccattca gatctggaac 1101721 ttgcaggata gccgcaaagc cgacgaaaag gacgaagagc aggaccagct ggtacaaagg 1101781 catgatgatg gcgtttttac gaaacacttt tgggttttcg gctgaatacg aagcggaaaa 1101841 cgtgtgaggc cacatgtaaa aaccaagcgc tgtcaagagt acggttgaac tgaaccaggc 1101901 cacactttgt cccgattcgg ggagcgtaag aaagccaggc tttgccgttt caatctgctg 1101961 aaacatgtct tgaaatccgc cgtagtaatg aattggcaaa tacacaccta aaaacagaac 1102021 gacaaccaga atcatgatgt ccttcacaac cgatatccag gcagacccgt gaatgcctga 1102081 aaccataaca taaaccgtga tggaaacagc gccgatccag atggcagcgg tcggggtgat 1102141 tttgccgtac gaggtttccg atacaatcag cccgaggcct ttcagctgca gtacaagata 1102201 gggaatgagt gcggcgatgc cgaccagtga aacgagaatg ccaagcagcg gactgttgta 1102261 tttttttgtg aaaaaatcag actgcgacat cagtttatgc tgtttcgcgt acgtccaaac 1102321 tgctggaaga agccagtaag aaaggatgta ggccagacat ccgtaggcga tgatataaaa 1102381 ggctggaccg ccttttccgt aggcccagcc gctgccgccg agaaacgtaa aagtagtata 1102441 aatttcgcct gccatcaaaa ggaagacgaa aacagttccg aagccgcgcc ctccgaccgt 1102501 ccactgctcc aggttcatgt cttttccttt ttgggcgcgt ataccgagaa aaatactcaa 1102561 gagcaggaca ccgaagatga tgatgagagc tgcattcatt ctgcttcctc ctttttattt 1102621 tccttgtcga ggacatacac aatcgccatc agcgcagagg tcaaaagagc ccacatcaca 1102681 atataggcaa gaataaacgg catgccgaac acataggggg tcaccttatt tgcaaaaggg 1102741 atgccgagta agattccgat aaagggtaaa gcggcaagaa cgtgaatcag tttcatagaa 1102801 tcctccttct atttaggatt gaggtgtaca agcctaagcg tactgaaaat gatgtcgcag 1102861 atatcgcagc acatgtcatt ttttggagtg aaaggctgtg gttcgaatta taaataaatt 1102921 tattttgttt gtatagtgtg aattgtctga aattaatgct ctgaatcgcc cgaagaggga 1102981 acgggcagta tgattcaaaa ggctcagagt ctgtctgggg caaatagata gtatgttaat 1103041 aattcgctga cctgctcacg gattcgcgga ttaaaatagc gatggttttc ttcataaccg 1103101 tcgatgacaa atgtatagag tgtaaaggcc tcatcgcgtt ccgtctcgcg gattgcaatt 1103161 tttcttttcc tcagttcttt tctgacctcc atcaaatcct tttgtgctat ttttaatgat 1103221 tcgctgataa gctgtttata aggatgcttc aattttaatg tgctttcttc aattccggcg 1103281 agatcacggt taaaaatcgt aatggccatg ggcaaaaaga gagcccgttc aattaaatcg 1103341 tatatttcct cctgcagatt tggcatattg actccttctt tctaagggaa cgtttgttct 1103401 atttgtattc tatatcggct ggtgaaatgt ttcaagacag aaaaaatcac caaaactttt 1103461 tagttttctg ctgataatgt gtagaataag gatagacaaa cccggtaagg agtataaatg 1103521 ttggagcatt ttttatccta tttgacacaa gaacatttaa ctgaattatt tcaaagctat 1103581 agggctttcg gtccgctcat tgctgtgctg ctgcctttaa ttgaagcatt tctcccgttt 1103641 ttgccgctga tcgtgtttgt ggtggcgaat acgaactcgt ttggcttgtg ggaaggattc 1103701 atcctatcct gggcgggatc aactgctggt tccattctcg tctttttgat tgtccgtcaa 1103761 tacggacaga gaaaattgct tggatttatc cgcagtcatc cgtctgtcag aaagctgatg 1103821 ttatgggtgg aaagacacgg cttcggtccc atgtttcttc tgctttgttt tccatttaca 1103881 ccgtcagccg cggtgaatgt tgttgccggt ttgtcaagga tcggaacgcg gccgtttatt 1103941 ttggcggcag cctcggggaa gcttgtcatg atttttatga tcagcttcat cggatatgat 1104001 ctgcacgcgc tgattacaca gccgattcga acggtcatcg ccgtattggt gatcactgtc 1104061 ttatggtatg tcggcaaaaa ggtggagcgg tatctgcatg taagagccag tcagcgtgag 1104121 catgatggag ggagacagta acatgaaaaa acggttttgg tttcttgccg gtgtagtgtc 1104181 cgttgttctc gccattcagg ttaaaaatgc tgtctttatt gattacaagg tagaaggcgt 1104241 cagtatgaac ccgaccttcc aggaaggaaa cgaattgttg gtcaataaat tttcgcatcg 1104301 atttaaaacc atccatcgtt ttgacatcgt cctttttaaa ggccctgatc ataaagtgct 1104361 gattaaacgg gtaatcggct tgcccggtga aacgatcaaa tataaagatg atcagctgta 1104421 tgtgaacgga aagcaggttg ctgagccatt tttgaagcat ttgaaatctg tttctgccgg 1104481 cagccatgta acgggtgatt tttctttgaa agatgtgacg ggaacaagca aggtgccgaa 1104541 aggaaaatat tttgtcgttg gagataatcg catatacagc ttcgacagcc ggcattttgg 1104601 tccgataaga gaaaaaaata ttgtcggtgt gatttctgat gccgaataaa aagacgctaa 1104661 ttgaagaggc gtctttttgt atgccgtttg gaaaaatgtg ttgaagaaaa atttgtaagg 1104721 agctataatc aaaattgtta cctgtgtaac aaaatttata tatttttttg actggagggc 1104781 cgtttttatt ggtttttgtt cgtttttcat gaaacaaaag gagtggtgaa tgatgatgaa 1104841 atatgaagca gtgattatag gaggagggcc ggttggattt atgctggctt ctgagcttgc 1104901 aatagccgga gtgggaacat gtgtgattga acggcttgaa aaacctgttc cgcattccaa 1104961 ggcgttgacg ctgcaccccc gaacgctgga gcttcttgag atgagaggga ttttagagcg 1105021 gttcgtatcc aagggaagca agatacctac cggacatttt tcaatgctgg atacccgtct 1105081 ggatttttca ggcttggata cgagctgtcc ttacacgctt ttgctcccgc agtccaaaac 1105141 agaaaagctt cttgaagatc atgcacgaag cctgggaaca gaggtgtttc ggggtgccga 1105201 ggcgctggcg gttacgcaaa acggggaagc ggtccaaaca atttttaagg atcgggacgg 1105261 cagtgtacgg acgatcacaa gcaagtttgc cgttggggca gatggcgccg ggagtaccgt 1105321 ccggaaacag gcgaaaattg agtttccggg aacagacagc actgtcaccg ctgcgcttgg 1105381 ggatgtggtg ctcctttctc cgccgccgtc aggtgtgctg tccctttgca caaaagaggg 1105441 cggtgttatg attgttccgt tatctccaga ccgataccgt gtcgttgtga tcagccctta 1105501 tcgcacacaa acgccgaaag atgtgcctgt gactgaggaa gagctgaaag ctgacctcct 1105561 gcgaatttgc ggaactgact tcggtttaac cgacccttcg tggatgtcgc ggtttgggaa 1105621 cgccgcgcgc caagcgaaac ggtatcggga cggcagaatc tttcttgcgg gtgatgccgc 1105681 gcatattcat tttccggcgg gcgggcaagg actgaatgtc ggccttcagg atgcaatgaa 1105741 cctcgggtgg aaactggcgg cggccatcaa aggctctgcg ccttcttggc ttttggacag 1105801 ctaccatgat gagcggcatc cggcagcgga agggctcctc agaaacacgg aggcacagac 1105861 aaagctgatc gatttcactc aagcaggcct ccatttgcga agcatgatgt cggagctgct 1105921 ggccttccct gatgtgaatc gatatgtagc ggggcaaatt tctgcgctcg atgtcagata 1105981 tgaagctgat cgtaccatgc cgccgaatcg tttgaacggg gcaaggctcc ctgacatgaa 1106041 gctgattctt tccgacggca attcggaacg gctgtacagc tttctccaaa acgggacatt 1106101 cgttttgctg tcattgaggc aggaagctga tgatcatatc gaagtaaaag gcttacgtac 1106161 ggtaaccgcc tcgcttgcag aaccgaatga aaagttgcgg aatgtgcata ccatattgat 1106221 tcgtcccgat ggacatgtag cctgggcggt ggatgcatca gcgcccgatt gttccgaggt 1106281 gattcaaaaa gggatcagcc gctggttttc cgtcaccagc cgagtataat tcaattcgat 1106341 tgtttcatct gtaacaaaac ggtatgatag aagaaacaat cgaatgaaaa aggatggaaa 1106401 acccgatgaa cacagatcat acgaaacgca atctttttga attgtatgcg gagctcattc 1106461 atcagcagga gaaatgggag gggcttatta aagccttttt atctgacgaa ttgaggaagc 1106521 tggatgtaga gcacgggagt aaatctcaat tgacgatgac agaaattcat gttctatcct 1106581 gtgtcgggga caatgaacca attaatgtca cgtcgatagc agaaaaaatg aatacgacaa 1106641 aagcgactgt atcacgcatc agcacaaaat tgctcggcgc aggcttcctt cacagaacac 1106701 agctcagcga taataaaaag gaggtctact tccgattgac gcctgctgga aaaaagctgc 1106761 acagtttgca caaatattat catcagaagg ctgaacagcg ttttctgtca ttttttgacc 1106821 gctataccga ggaagagatt ctttttgcgg aacggctgtt tcgggatctg gtgacaaaat 1106881 ggtatccgtc gtcagaagaa attgaagggg ggcttcctag catttttaaa taaaaaacac 1106941 gcactgcggt gcgtgttttt cgctttgttt ctatcttttt caaggctgta acgtaaatca 1107001 gatttcctct tgaagaatga aattcaagat gttcaggaat ttgcactgct tatacgatat 1107061 gtctattagt atctttattt tatacgtttt ctactgtgtt tttgatgctt tgttttcaag 1107121 tgaaataggg tcttctgttt tagttctcct aatctttaca gaaataccta ctagaatgac 1107181 cgccatagtt gtaaatattc ccatggttaa taagatcgta tcctggttta aactccatcc 1107241 aattaagaaa gagatgatcg ctcctccgaa acttgccgag gcaataaata aacttgtaac 1107301 ttcgtcaacg tacttctgaa taatgattga tgctagtgtt aaagcaatgg gaaatatccc 1107361 cgctatactt aggccaatca aaaatgtacc actcaattga agtattgggt tacttatata 1107421 agagaaggca atcaacaaaa caattaaaca actacagcta aaaagaaggt atttggaaaa 1107481 atcaagcctt ctacttacga aaccaatcaa tattcttcct atgatgatcc ctacccagaa 1107541 aaaggagaca cttataagac taatttgttc attgtcttgg tttatcatga ttgaaggtaa 1107601 aaagttggca aaatttgttt caattccagc atataggaaa gcgaaaaata caaaaaagcc 1107661 taattgcttt gatttttttc tatctcctat aaagtattga aatgctcctc catctggaaa 1107721 ggtcacttgt tggttagcat tcttagcgta ctctcggttc ttagacaaga aaattaacca 1107781 ccctacgaat aggacgaata aaaaggtgaa tatacagtaa tatggtaaaa accagttatt 1107841 gatatctatg aaggaattaa ttaataatgg gaaagataaa gcgcctaatc caaagagaac 1107901 ttccagctta ctcatttttt ctgcattact ttcgaaatta gcaataacaa atgaaccaac 1107961 tgtcgtttct aatgtgcctg ctccatatcc taagagaaaa gccattacaa taatataata 1108021 ccaatccttg gttagaaaaa agatacttaa cgctacaagc attattgtca aagctaaagt 1108081 aagtgtccta aaatgactgt atttcttaat cattaaaggt gcgattaata ctccgcttag 1108141 aaatccggta aactggaaga agattatgac cgaaatatca tctgttgtct tgttaaaagc 1108201 ctctaataaa aatggtgtca aactccctgt tgatatatgg ataataccta ctgtaaaaaa 1108261 gaaagcatat ccaaataaat atgtccctct taacattcat tacaccccta tatgaaaaag 1108321 caggaaagta aattcctgct tttttagtaa cttctctctt tgaaatacta gttgactgct 1108381 gaaacagaca tgggttgaga gttgctgtct ttctcaaaga acatttctaa tacttcctga 1108441 gatctaaaac catcactaaa agaagggatc tcaacccaat cattctgagt tgatgcaatc 1108501 caattgatta actcgcttct aaaagaatca gcccatccat aaaactcgtt tggcggatcg 1108561 tttaataggc tttgcggtac tgggcagtct accacgttca agccatctat gagcttgtaa 1108621 acgtgaggat tacctgtgtg gtatttaaac tcttttttgt gtccaactac ctcaatgcta 1108681 aaaccacagt cttcaggtac agaacacttt gatgtgatga tatttacaaa taccttgttc 1108741 ttcagctggc cataaatttc tgcatagtca tctacaagta cctgtttatc ctcttttgtt 1108801 tttacatttg tgttcatctt tgcccttact gattctgtga tgaaatcact ctcgaacaaa 1108861 taccatacca tgtcaataag gtgaataccc agatccccca atgatccact cgtcttctta 1108921 ctattagcgt catctctcca agtaaacttc ttacgtctaa gtgcactatt tttcttgaag 1108981 tgtactttta tggacagtat gttacctagt tcattattga taattaagct ttttaagata 1109041 tttacgtaag ataaatatct ataattaaat cccatactgg ctcttacgct caacctttca 1109101 gcagtatctt tcattatgct tgcttcttca agagaaatag ccataggctt ttcacataat 1109161 acatgcttat gttttcctaa tgcttgcaaa gcatgttctt tatggcaaaa gtttggtgat 1109221 gctacaatta aaccttctga ggcatcaatt agttcatcta cgttttcaaa tgacttcccg 1109281 ccgaaagttt tcacaaagct ttccgcattt tgttgattta tgtcatatac ccctactaac 1109341 tctgcatttt ttattgtaga taaagcagtt gcatgcgctc ttgcaatacc acctgcacct 1109401 atgatgccta tcttcttcat ttttatttcc tcctcatgat ccaattaatt tttttaaggt 1109461 attagtaatt ccttttgagt actcactatc agttataagg ttgtgcaagt ttttggcttc 1109521 ctgtgttgca ttttttagca gatatccatt ccctactgtc tgtaacatac gaacatcatt 1109581 tccactatcc ccaaatgcga tagctctttc ggtatttagg ttgtatttct ctaacataaa 1109641 cgttacaatt tcattctttc ctgtccctat ggggataaaa tctacatcat agctgtcttc 1109701 tggatcgcct gctaagggat tacaccgatt tatatttact gaaacgccgt attcttcgca 1109761 gattttttca atagctaata ggtttttctt gtcgtttatt tcatcttgtt cctgatagta 1109821 gaagttatgc ttataccgtg actttcctaa ttgggtttga ggattcaaaa gaatgttatg 1109881 attttcatgc agctgtttca caagtttttc aaccttttct ttactaaacc cttcatttat 1109941 gcgactgttc cacttgttat cttgctgacc gaagttatgc tctgaaaagt acgtaatttc 1110001 agttccaaga tcactagcta taaaatgcgg aaaatatcta aattttcctc gtcccatttt 1110061 atcgagaata gattctatac tgctcccagt aacccatccg attattagct ccccatcttt 1110121 acttttttgt tctagatagt cttcgagttc atagatgtct tgttgctttt gttcgtcgat 1110181 tgtatgcgga aaatacgttt catcaaaatc acaaaaaaca atatattgag gatgttcaac 1110241 cgtggataac gttttatact ccgatttctt gcttaataac atgaaacagt ccctccatta 1110301 ctctgtcttg ttcttctaaa gtaaatgacg gatataaagg caaatgcagt acctgactat 1110361 gagccttttc cgtatgaacc aattggagtc ctgcatactt gtcctgtact aaaggagttt 1110421 tttgcatatg agaaagtatt ggataatata catctgtttg aacaccaaaa tcttcattta 1110481 atttagtcat gatatctgcc ctatcttctg ttcttacctt aataggaaac agatgccata 1110541 catgatcttc acttaattct ggtaattcaa tatagccttt attctgcaac tctgctaatt 1110601 gggtaatgta tctatccgcc aagaacaatc ttttgaagtt gtttaatgaa aggtacttca 1110661 ttctctctaa accaattgct gcctgtaaat tgtccatttt tgaattaaat ccaaaattga 1110721 tgactttctt attttttaca tttacttcaa aaccgtgata actaaattga atgcattttt 1110781 tagcgagttc ttcattatca gttgctattg ccccagcctt gccacataca ccaaaattct 1110841 tatagggatt aaaacttaat gtagtgatgt ctgcatactt tcctaagtct gtcagtccaa 1110901 ttccttggca ggcatcttca attactttta atttataacg atttgcgatt tgacggatat 1110961 gctgcatgtc tgaatgtttt ccgtataaat gcacaggtag aataaacttt gtataaggag 1111021 ttattgcttc ttcaattttg tcaggatcga tgcagaatgt ttgtgggtta atatctacat 1111081 agataggaac gcctcccgaa gctaacacag cattttcagt agctgaaaag ctattagccg 1111141 gcatgataac ttcatcccct gggtttaacc ctaaagccaa taaacctatc ataatagcat 1111201 cggttccact gctggttgca attacatacc ttttatgtaa atatgtagat aaaacttttt 1111261 cgaattgctc taaataggga ccactcgtaa attttccagt tggcaaaact tcagttaatg 1111321 tatttaagat atcttccact tcatcattgg ttattaatct gtctacaggc aaaaaaggga 1111381 ctttactgat ttcacgattt ttttgatagt tgaaaaggtc atgttcaata tctatctttt 1111441 cttttaatac ttgtttccac cgctcgttta caatactgtc ttcaataaca agttcttttc 1111501 cttgtacgtc accttttaag tgttttaata gtgacatgtt ttctttgctt ttacctgaaa 1111561 tcttaacctg tttttgcatg aacagtacct ccaatgattt tataatctaa aaatttatta 1111621 caaatttatc ctagtttctg aaatcggtaa catgtcaaca acttttttaa ggaagggaaa 1111681 atatgcctac aattgatgaa atagcaaaat tatgcaatgt gtctaaaacc acagtgtcaa 1111741 gagtattgaa taatcatcct tatgtgtcga aagaaaaaag agatatgatc ttaaaggcta 1111801 ttaacgaact tgactacact cccaattatt tagctcggaa ttttaggaga aataagacac 1111861 aaacgatagc tttatcggtt ccgagtatcg accatccatt ttttgctcaa ttaataaaag 1111921 gggtctctca tgaagtactg tttaagaatt acaaggtaat tgtatttcag accttttatg 1111981 acaaacagac ggagctagaa ttactagagt tattgaagca taaagaagtg gatggcatta 1112041 ttcttgggac tttagaaaat gaatgggatc agatatcccc tttcttaaag tatggtccta 1112101 tcttattatg taatgaatat catcactcag cggacatcac gataattggg tatgatgaat 1112161 ttgaagccgc atacatgggg gtagtacatt taattgaaag agggcataaa aaaattgggt 1112221 tttgttttga tactccatat agcgaagctc aatgtcagag gaaagagggt tatttgaaag 1112281 ctttacaaga ttacaattta catcatagaa gcgaatggat attcggcgaa atgtttaata 1112341 tcgaggatgg ctttcgtgtt tttcataaga taaaggatct aaaggacaga ccctcagcaa 1112401 tatttacagg aaatgatcaa gtcgccgcag ggattattaa acaggcgatg aaaaatggct 1112461 ttaaagttcc agaagactta gctgtaattg gttttgacaa ccaattgatt tgccaagtcg 1112521 ttactccgac cataacaaca attgatatcc ccgtaataga attaggccaa caggctgtgt 1112581 tgaaaatcat cgagtccatt tcgggtaatg cctctttaaa cagaagaatt attaaactgc 1112641 caacaaagct tattataaga gaatcaacgt aacgatagat ttccctttaa cattttatat 1112701 ctttatataa gaaaaagagg ttattcattt taacctcttt ttcaatcgta agtcgtcaat 1112761 tatttctttc atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa 1112821 atatccgctt atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt 1112881 ttcaactagg cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga 1112941 tggtgaagca ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc 1113001 tgaaccgcaa cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct 1113061 gcaatcccgc cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg 1113121 gaaacgatca cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg 1113181 acgatgataa tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt 1113241 gccccgagaa atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg 1113301 tgccctgtca ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc 1113361 agccatggag ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga 1113421 ataagaatga cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc 1113481 gtctctgctg cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac 1113541 ggaatggaaa gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta 1113601 ttggcgccta cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg 1113661 acaaagctag tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg 1113721 gccagcagga tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca 1113781 gagagaacgg ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg 1113841 gcgagccatc gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt 1113901 atcatggcga ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg 1113961 gttaatgaaa gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg 1114021 agattttcgt ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg 1114081 ttcacgtagt gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat 1114141 tattttctat aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta 1114201 agtcagagat aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc 1114261 gccaaatgat gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca 1114321 atgcagacca tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat 1114381 gaaggtctgg atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac 1114441 taaaagcatt gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat 1114501 ataagtaatg aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac 1114561 ttggagaaca cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata 1114621 atcagaaaac atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat 1114681 gctgatgggg agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc 1114741 ggacattttc ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc 1114801 gatcagaaag tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg 1114861 attgtacagc agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt 1114921 gatgaccgca aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg 1114981 ggaagcggga atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac 1115041 atacgcatgc tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt 1115101 caaaatcgct gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa 1115161 aatatcagca aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa 1115221 ttgttcatgc agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag 1115281 caattcgccg aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa 1115341 actggtcaac atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg 1115401 gcggcggccc aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc 1115461 ggggattgaa gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg 1115521 ggcaaatgaa cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa 1115581 atgcaaagct cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg 1115641 cggggcgcgg ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc 1115701 aaactgcaaa ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc 1115761 agtatcagtc cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat 1115821 tcggatttgt gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca 1115881 cgcctgaatc tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt 1115941 tcgtcaaaca gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc 1116001 ctcatttggt tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa 1116061 aaggtgtgtt atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc 1116121 agcgcttttt ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag 1116181 tcttagaaaa gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc 1116241 cgtatgctct ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa 1116301 atggaacagg gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca 1116361 atgagcgcta cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc 1116421 aagccggaga gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa 1116481 ctgtctttga tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc 1116541 ttcagcaccg aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc 1116601 gtgaagcggg agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg 1116661 agtgggaggg cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa 1116721 tcgtgcttta taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata 1116781 tttgcgccca gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac 1116841 ggccggaaat cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca 1116901 gcgagtttgg ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat 1116961 ctgaaaagct gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc 1117021 gctgttcgag aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg 1117081 cgatcccgct gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg 1117141 tgcttgatga agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg 1117201 gttctttttt gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga 1117261 agcaggcttt cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc 1117321 atgcttcaca aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt 1117381 gcatggcttt gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc 1117441 cgctgagatg atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct 1117501 tcatgcaatc gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc 1117561 cctgtatgac agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg 1117621 tgtttttagc taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca 1117681 gatagtatag gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc 1117741 ctttcgcttt taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt 1117801 gttcatcttt aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt 1117861 gtttcggcat gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt 1117921 ggcgaatctc gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga 1117981 gttcggcaag cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca 1118041 aattccgaat caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat 1118101 gcaaggggat tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag 1118161 ggagagatgt gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga 1118221 tcagattggt cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc 1118281 ttctaatttg ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat 1118341 catcaacagc attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct 1118401 agtcccggat caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg 1118461 cgggatgata cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca 1118521 tacgggagga atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa 1118581 gctcattgag gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg 1118641 gtttaccgca caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga 1118701 ggatatccgc cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt 1118761 atctgaaaag ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga 1118821 tcaatatctt cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga 1118881 agatataaaa ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt 1118941 cagggtgttg gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga 1119001 caagccgtca tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac 1119061 ctattaccgc ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct 1119121 gagcgggact gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga 1119181 agcgcgtccg gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc 1119241 aaacagacga gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa 1119301 gggatatcgc tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat 1119361 ggtgaaggaa gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat 1119421 gctgaaccat ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg 1119481 gcgttatgaa gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc 1119541 gaaggccaaa gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat 1119601 taaaggcgac cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga 1119661 tgatgatttt gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg 1119721 cgattggatt gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt 1119781 tcaagagaag gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct 1119841 ggatcaggaa aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca 1119901 gcaggcgtgg gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga 1119961 tgagatttct cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt 1120021 ttctctaatt ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat 1120081 gtatggcacc tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc 1120141 tgatgaaaac ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga 1120201 gctatcctca ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt 1120261 ttcaagtccg tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac 1120321 gcttttgccg tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg 1120381 cctgttaaca aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa 1120441 taaaagcgtg gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga 1120501 catcagcgac gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca 1120561 atcgaaaaag ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag 1120621 cgtgtcgaga cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt 1120681 taacgcatgc ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt 1120741 cttcaagctt gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc 1120801 ggacaggctg cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct 1120861 gttttcctat gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag 1120921 ctcaaaccgg cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg 1120981 cattttaagc gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt 1121041 tggaggaaaa gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga 1121101 actcgtcggg cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag 1121161 gattgtcgat tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt 1121221 ggcactgcaa atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg 1121281 gatgagggcg acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc 1121341 taatctcccg cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa 1121401 gggcttgctc ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg 1121461 acgttcaaat atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc 1121521 agcagtcggt gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga 1121581 agcgggcgaa caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa 1121641 gacgccgtgc acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga 1121701 aaacgagtat cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa 1121761 ggaggcggat ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat 1121821 ggaatgccat tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta 1121881 aaaccgctgt gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag 1121941 atgtagaccg tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc 1122001 gaatcgcaga agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac 1122061 gccagctgtc tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag 1122121 tgctgaagaa atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga 1122181 cggaaggcga gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa 1122241 agggcgaaaa ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg 1122301 atctgcaatt tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg 1122361 cgtggctgga aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc 1122421 tgccgtttta tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa 1122481 agctcttgcg cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca 1122541 attttcttga tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg 1122601 aactatataa gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg 1122661 agttcgatcc agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc 1122721 ttgaaaagct caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag 1122781 ccgagatgaa gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat 1122841 tcgaagctgc gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt 1122901 tagcgatttt gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt 1122961 tttatcagga acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc 1123021 aggaatcgat tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg 1123081 taggagatgt caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct 1123141 ctaaatacaa acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata 1123201 aaaatttccg aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga 1123261 tgggcggcaa aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag 1123321 cgtatccgga caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata 1123381 cggatgcaag cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg 1123441 ctaaggaaat tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa 1123501 cacatcgcaa tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc 1123561 cgcaaatcat ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag 1123621 gctattttga agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc 1123681 cgtatcagga tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa 1123741 acgagctgtc tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag 1123801 actacctggc tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg 1123861 gacatctgca aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg 1123921 aagtgtaccg cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc 1123981 gccaggccaa tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc 1124041 gcggcttgtt ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg 1124101 gtacggcgag agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca 1124161 gcaaagggct cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga 1124221 tggatttgaa caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc 1124281 atccgcaatt acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc 1124341 gcagggagct gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg 1124401 aaaagctgtt tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg 1124461 catccgcgtc ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt 1124521 atctagattt cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg 1124581 tgccagcaca cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt 1124641 cctatgattt gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag 1124701 aagcgatccg ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg 1124761 agcagctgag ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag 1124821 tttctgagat caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa 1124881 aaccggctga tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga 1124941 cagcggcaga gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg 1125001 tgccgtcgat agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca 1125061 ctgaagaaca aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa 1125121 tcggcggaca gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc 1125181 ttccggccaa ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg 1125241 gtattattga ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg 1125301 accggattga gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac 1125361 gatatgaaac gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg 1125421 taaagggatg tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc 1125481 cataagctcc ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa 1125541 gcatttgcgg attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag 1125601 caggctgagt gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca 1125661 gatcgatgcc attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc 1125721 cgagcagctg ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt 1125781 cgtcattgcc ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca 1125841 tgaaaacggc attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc 1125901 ttcagcagga gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa 1125961 tgaagtgcta tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat 1126021 caggcaggcg tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc 1126081 cagccatatt tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg 1126141 cggtgcatac acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg 1126201 ccatttgcat cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc 1126261 tccgctcgcc tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc 1126321 aaagcctggg gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt 1126381 gaagtggaaa gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga 1126441 tcagaatgct tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat 1126501 tcacaggctg cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca 1126561 gaacaaagac cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa 1126621 attttatgaa aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt 1126681 agagcttgca tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt 1126741 aaggggctcc acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc 1126801 ggtgttttcg gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg 1126861 acgcttgctt tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat 1126921 cacgccgaag atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc 1126981 tcatacaaag tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt 1127041 tgccgcttca tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg 1127101 aataaaagag tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg 1127161 ctgccccaag ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg 1127221 cttcagcgtt tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg 1127281 caggcgcagg aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt 1127341 gaggcgagct cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg 1127401 ctggaagcga tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag 1127461 atatggaatg tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa 1127521 gaacagccgc atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc 1127581 cttaagccct atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag 1127641 gaacaaacgc tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat 1127701 gaagagtatg aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa 1127761 caggaacagc tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag 1127821 gaagagcgca aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat 1127881 gaattagaga ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag 1127941 cagcagctca aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca 1128001 gagatggcat tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt 1128061 gaagaattga acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag 1128121 acggaagcgg aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat 1128181 ttggtgtgcg aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa 1128241 cacacgcttc acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc 1128301 caaaagctga ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct 1128361 gcctcggtac atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca 1128421 gatgtgttat tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg 1128481 cttgaagaac agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca 1128541 cagaaccttg aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact 1128601 gccaaatttg aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca 1128661 caaatgattg gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc 1128721 ggttttgaaa aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca 1128781 atggacagca gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca 1128841 gaaaaatggc agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga 1128901 attgagaaga gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa 1128961 tcgggacacc ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag 1129021 agcgtgatag ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa 1129081 atcaaactcc gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta 1129141 tatgaagaac tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca 1129201 agcgagctca ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt 1129261 gagcatacaa aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca 1129321 gctgatgaac ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa 1129381 aatgctgcaa acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc 1129441 gaatggaacg aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata 1129501 gaggaaaaag gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt 1129561 aatgaaattg aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg 1129621 caagctgtgt ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc 1129681 gttgcgaggg acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa 1129741 gtagattctg agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg 1129801 gtttccagtt tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg 1129861 tctgcgcaga ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc 1129921 ttcggcacac tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag 1129981 tcagacaacc tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg 1130041 aaaaagctga tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag 1130101 ttgatgtaag ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg 1130161 ccggagcgat gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt 1130221 tttgccgaca gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa 1130281 tcaagagctc gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc 1130341 ccggtttgtc aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc 1130401 aaatgaacga aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct 1130461 tttatccgtt tccaaccata tcctgatcgt tgacatcggg gtctatataa tttgtcgcgt 1130521 tgactgcatt atttaataga aggaaatctc ccgtgtttcc tgctcccgaa ccgagcgcag 1130581 attttgaaga gcttttcgga gaaaggtaaa aggaatcacc aaagtttacg actccgcccg 1130641 atatggaatt gatagctata ggcccgacaa ttgctggcat aaacgacacc ctttatcgaa 1130701 gtctctgttt attatatgtt cttggcgggc gattgtgagc gcggagactg aatctgtctg 1130761 atatgtttga gtctcgcatc accgcgaata agcgaagctg atccggcatg taaaacagaa 1130821 gaggctgaga ccccttgaat tttgatgctg cgaacataaa tagccggcac ctcgtggcaa 1130881 aacgcgcttt gtacacctgt ttcggggagc ggcttcacgg cctgctgctg aaagatctga 1130941 tactcctttt tgttaaatga gccttcatta tggtaaaacg tggacagaga acgctgcaca 1131001 gcaaatactt ttacactcat atcgatttca tttgtgtcgc caacttgaaa cacacttgcg 1131061 atcccgagag aattaaactt aactagtctg atgcgcgata tgcgtttaag cattattctg 1131121 gcgcaagcgg agcaaacggc ccaataataa gagattcagg cggtgtatca aaaatagaag 1131181 acaggtagat ggattcagtg tctccgatgt ggaaaacgga ggaactggac acaccgttca 1131241 tccgaatatc cccgacttcc aagctgcggt tgatgactgt aaagatcatg cttgctcatc 1131301 tcctttcatt tctgatggaa tatgctccag aaagtgttct acagcgcgga tgacatcacg 1131361 cttcacatgc tcagcgatat gttctgcata ttgtgcaggc ggtgtatttt cttctttttt 1131421 gatatgggac atataatagt gaatcctgct gtccatttgt tttctgatgt cttcaataac 1131481 atgatgtctg tttgtatcgt caagtctgct gtcatattga ttttcaagct gttccaaaat 1131541 atctgggatt tcctcggtta agtacatgtc gacattctgg cggatctgct gcatgagctg 1131601 agcgctctct tcctgctgca tcatcccgat ttgcggtgtc gactggctga cgtcaaagtt 1131661 ttggacgctg ttcgggtcag tcggatttaa accgatattc aaagtcccgt cgagcctttc 1131721 gattttcagc tgatcaaatt tatactccac acgctcaatg gtagtggccg gccgctgttt 1131781 catcgtattc atttcagttt gaatctcttt cagctgacgt tcgagctgct gaatgtgaat 1131841 cgcctgctgc tgaacgaagg aattcaagtt ttgcaggtaa gaggaaacag attgatcata 1131901 catgttcttc acctctttca tatgattaac ggccaggagg ctggagcggg accaatgaac 1131961 ctgtgtcggg ctcctgcagc tggagcggtt gccctgagcc agaaacttct ggtgccggct 1132021 ctacatagct tcctgtatta tacaaatttg acagtgactt gattgatccg gcgctcccga 1132081 tttgcagaat ggaggagttg ctgattgatt ccagccggag atagttgatt tgaatggttt 1132141 gattaatata gaagttcatg agcctcactc cttttacgca ttggccacga tcggctgatc 1132201 aaccgcatca ttgtcataca cattcgtcgc gttttgataa ttcatcacct tgaggctgtc 1132261 gccggtatta aagctgccag caccggcaaa cgttctgacc tgagcctgag gagaaatcgt 1132321 aatgcagtcc ccgatgtgaa cgactccgct cgtaccaatc gcattaattt taaacgctcc 1132381 gacaatggcc ggcatacgag cacatccttt gttgaaaaat taaaaaaaga caggtaaagt 1132441 gaaatgacaa ttccgatttc aattgggcta ttcacgatag cttatgacaa acgcacatat 1132501 gtgtgagaga aattttaagg ggacatatcg gctctttgtg aaagcgtttt attttttcgg 1132561 gccgttatgt ttaaacatgg caaaagagga tgttgggtat aaattgagcg gaaatgcggc 1132621 gaaggatgcc gctatccgcc tatggtgatt tttgtttatt tctttggtgt ttttgcgtgt 1132681 agaatgcttt ttggagtatg tcgtgctgcg gtattcgatt tttgggcggg cacattctcg 1132741 ccctgaggta tatctcagaa gtgctgagca aaaatcggag ttaaatgtgg tgtattctaa 1132801 ttgttataga aaatgattta catacgggag ttttcaagat atctcccaaa aatcatttct 1132861 tctttaatcc gggtattcag caggatatcc agctcttggc tgcattgaat cgtttctttt 1132921 gaattcatgc cgtatttttg tgcggtttca attagtgtga tcctcatttc ttcaatttta 1132981 ctgttcatta cgctatctcc aattctagat tttattttga tataaataca ggatatcgtt 1133041 agtataacct attttggctc aaaaggttgc ctttcgtcaa tttgactaaa aaagcgacaa 1133101 tttttgctgc ggcctttttt aatggagaaa ggactaaagt cttgctaagt gtgcttgcaa 1133161 aaagtcctgc cgttcctcaa tttctctaag tatgttggtc tgctcctttt cgatttgaaa 1133221 ggggcttttt ttgataaaag gatcatcagc agcactttga caaatgtcaa ggtgccattc 1133281 gttgatgaga ggagataatc gttcaatagt aaacgaccgc ttcagcacgt ttttcattaa 1133341 ggtgtgatat tgcgacctga aggcgggaat ggatagaagc cttgacgaaa gcgtctttcc 1133401 ttttgtcaga agcgggtctt cttcatacca ttcttgtacg gcaagcgatc ttgtctccat 1133461 cggggaaacg taaagccgac cggattcgtt taaacaaaat gtgtagtaaa agccttgatt 1133521 ggtgcaggtg ttgccgatca gccacaaaaa aaacagcttg acatccagat acaatttaat 1133581 cctttcagcc aattcgtcat ctccggctgt gcggatcagt atgaaaaatt catgtaagaa 1133641 tgccgaggaa tcattgttaa aaagggacaa tggaaccctt ggatcggccg tcttcactcc 1133701 gtaactcctt ttaccggctg gctgatggtt cttgatgttc aaataaatgc cttcaggctg 1133761 gccattgatg gtcagaaagc tgtacgaggc aacgggagca ggtacgccga tctggtcaaa 1133821 aaaacaatag gcgagtctgc gccgcatcag ggacggatca tcctgttctg cattcaaaaa 1133881 aagtgtcctt tcaccaagca gagacttttc ccagctgatt tcataggatg ccttttccgc 1133941 tctgtcacgc tgtgtgagaa gaatgggaga aacagatcga tctgttacga aaagcccctt 1134001 ggctgtacct ttccttttca gctgctcccg atgaaaaaat aaatgcacgc gctccatatt 1134061 ctttcctcct tctcaaaacg acatttgtat gatatgtaga gcaagcccgt cctgaaacga 1134121 aatgaaaacg gaattgagaa aaagggattt cagcattcga cagagaatac atgaaggagc 1134181 attctgattt aaaagatgat ggaggaataa catgaaattt gcgacagggg aactttacaa 1134241 ccgaatgttt gtcggcctga tcattgacga tgagaaaatt atggatttgc agaaggctga 1134301 aaaaaaactg tttgaacttg agacgattcc gggatcgctg attgaatgta tcgcagaagg 1134361 ggataaattc gttgcgcatg caaggcagct ggccgagtgg gcaaagaaac cgaatgatga 1134421 gctgggatca tttatgtatt cattatctga ggtgaagctc catgcaccca ttccgaagcc 1134481 atcaaaaaat atcatctgca tcggcaaaaa ctaccgggat cacgcgattg aaatggggag 1134541 cgaggctgat attccggagc atccgatggt atttacaaaa tcgccggtaa cggttacggg 1134601 gcatggtgat atcgtaaaga gccatgaaga ggttacctct cagcttgatt atgagggaga 1134661 acttgctgtc gtgatcggaa aaagcgggac tcgcatttca aaagaagatg catatgacca 1134721 tgttttcgga tatacgattg tgaatgatat cacggcgcgt gatctgcaaa aaaggcataa 1134781 gcagtttttt atcggaaaaa gcttggatac gacatgtccg atggggcccg tgcttgtaca 1134841 taaatcatct attcaggagc cagagcgcct caaggttgaa acaagagtca acggcgagct 1134901 gcgccaatcc ggttcggcaa gcgatatgat cttttccatt ccggaattaa ttgaaaccct 1134961 ctcaaagggg atgacgcttg aagcgggcga cattattgcc accggtacgc cgtctggtgt 1135021 cggcaagggg tttacgcctc caaaattctt gcggtcaggt gacaaaattg atattacaat 1135081 tgatccgatc ggaacgctgt caaaccaaat tggctgaata aaactggagg gcggacccgg 1135141 acccgcccgt tttttctgat aatcatcttt gtgacagagg acaagttcat ggtactataa 1135201 gtggggtaat ttatctgata gggggaacat atatgacaca cctacatatt acgacatggg 1135261 tggtagcgct gattctgctt ttcgtcagct actcgctgta ttcgtcagga agtgcaaagg 1135321 gcgcaaaaat cactcatatg attctgcggt tattctatat ccttattatt ttgacaggag 1135381 ctgagctgtt tgtccgtttc gccaactgga acggagaata cgccggcaaa atgattctgg 1135441 gcattatcac catcggcctg atggaaatgc tcctcatccg caagaaaaaa gaaaaatcaa 1135501 caggaggcct gtgggtcggc ttcgtcattg tccttttgct gacagtgctg ctcggtctgc 1135561 atttgccaat tggttttcaa ttgttttaat agaaaaacct atgaacccgg ctctttgata 1135621 gagctggttt tttttatatt tatcccctca tattccaaat catttaaaat aaccttaaaa 1135681 ttccctgtaa gcggtatctc gtcctatgaa attatgatac cttcaaggag attcattatt 1135741 ttgcaggagg gataacatga aacgcagaaa attcagctcg gttgtggcgg cagtgcttat 1135801 ttttgcactg attttcagcc ttttttctcc gggaaccaaa gctgcagcgg ccggcgcgat 1135861 cgatcaggcg gctgctctgg aaaacggcaa agagcagaca ggcgccatga aggagccgga 1135921 acaggtgaaa tggtacaaag tgaccccggg agcaacggat attcagaaaa actcacatat 1135981 ggcactgacc gtaaagagtg attcagtact gaatgtatct gtatatccaa gtaaggaaaa 1136041 agcgcttaaa gatgagacgt ttgagatgta ccgttctttc acagcggagg atggaaaaag 1136101 cgaagtcatt tttccatacg cgtggagcgg cccttactat gtaaaagttg aatacctcgg 1136161 agaagaagaa ccagaggacg gcggaacggc agaagcagct gcagaagcca agtatacgat 1136221 tgggtataaa ggcaccaaaa aacagccgtc agatttagaa gaggaagaag cttgtccggt 1136281 tgaaatgagt gtcgatcaga agaaatcagg aaaaggcatc ctggataagt tgagatcgat 1136341 tcgtgatgag cagctgagcc aaacagcaga aggcaaagaa ctgacaagcc tttattacaa 1136401 agcagcaccg tttatcgttg caaagctcgc actcaataaa acagcaagaa atgaaatcta 1136461 tcaggatctt gtgacattaa agccgttatt tgacgatgtg tcagaaaacg gagcatcatc 1136521 ttcgtataag gtcactgaaa aggatcaaaa agcgatcaac cggctatatg ataaagcttt 1136581 acaatcagtc ccgtcattcc ttaaagagga gataaagaaa caagcggacc gactaaatat 1136641 gaagcagctg caaggcaaaa cagcaggagc cattttaaca gaaaacaata ttgcagcaaa 1136701 aagtgaagtt cagacaacaa aggttatttt caaggtgaag gacaataaaa gcctctcatc 1136761 cgtacataat gaaatgaagg gcttttctgc aagcgcgcaa tcgaaaaaag acatatctaa 1136821 tgtgaaaaag gcaaagaaac tgtttgacaa tctgtattca tttgaacttc cgaaagacga 1136881 gaaacagaac ggcgcatata cggcaagcgc caaaagggtc aaaagcgctg ctgcgacact 1136941 atccaagatg tccaatgtag agtttgcgga acccgtacag gaatacaaaa gcttggcaaa 1137001 cgatattcag tacccttatc aatggccgct taaaaacaac ggtgaaaacg gcggtgtcaa 1137061 aaatgcggat gtgaaatatg agcctgccaa cacattgctg tccaaacgca agcttaacga 1137121 tacactcatt gcagtagtag acacaggcgt agacagcacg cttgccgatt taaaaggaaa 1137181 agtaagaaca gatctcggac acaattttgt cggacgaaat aacaatgcaa tggatgatca 1137241 ggggcatggg acgcatgtcg caggcattat tgcagcccaa agcgataacg gctattcaat 1137301 gactggattg aatgccaaag caaaaatcat ccctgtaaaa gtgcttgatt ccgcaggttc 1137361 cggagatact gaacaaattg ctctcggcat caaatatgct gctgacaaag gagcaaaggt 1137421 gattaattta agtttaggcg gaggctacag ccgcgtgctt gaatttgctt tgaagtacgc 1137481 agctgacaaa aatgtcttga ttgccgcagc cagcgggaat gatggagaaa atgccttatc 1137541 ttatcctgca tcttctaaat atgtgatgtc agtcggcgca acgaatcgca tggatatgac 1137601 cgctgatttc tctaactatg gaaaaggtct ggacatctct gctccagggt ctgatatccc 1137661 gagcttagtg ccgaacggaa atgtcacgta catgagcgga acgtctatgg cgacgccata 1137721 tgctgccgcc gctgcgggac tgctgtttgc tcaaaatcct aagctaaaaa gaacagaagt 1137781 tgaggatatg ttgaaaaaga cggcagatga tatttccttt gaaagtgtcg atggcggaga 1137841 agaagagttg tatgacgatt atggcgatcc gattgaaatt ccgaagacac ctggtgtaga 1137901 ctggcattca ggctacgggc ggctgaatgt catgaaggct gtcagcgcag ctgatttaca 1137961 gcttaaggtc aacaagctgg aaagcactca aacagctgtc agaggaagcg cgaaggaagg 1138021 cacccttatc gaggtgatga acggcaaaaa gaaactcggc agcgccaaag ccggaaaaga 1138081 caatgcgttc aaggtgaata tcgcgactca aaaacaggat caagtactgt atctgaaagc 1138141 aacaaaaggc gatgcgaaaa catcgtataa agttgttgtc gtcaaaggaa aaccttccgg 1138201 cacaccgaaa gtaaacgcgg tgaaaacgaa ggatacggca gtaaaaggga aggcaaacag 1138261 caaagcgatg atcagagtga aaaacaaatc aaagaaagtc attgcttctg ccaaagctga 1138321 cgcaaaagga acgttttcgg tgaaaatcaa aaaacaaaaa gccggaacgg tgctgtacgt 1138381 cacggctgtg gatacagata aaaaagaaag caaggaagca aaagttgttg ttgaaaagta 1138441 accaaaaagc ggtgctcgat gcaccgcttt tttatttgcg cccccgttgg actgctgtgt 1138501 acataatgga tcgctttccg tttgaagccg tccattcaaa acggtctcct gtcccttcgc 1138561 tgctgtagtt gtagtgatgc tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa 1138621 aggacacacc ctgccccgcc gaagtattcg aaaagactcc tttattataa gaaaagacgc 1138681 aatcgaatac cgataagccg aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt 1138741 cgtcaagcga atccaaaagc gccatgagcg gccgcttgac tgatttctca tagcggatgc 1138801 gttctccgcc ggaaagggag atgttttctg caccgcatgc caaaaccaac ttgtcctgaa 1138861 agccggcttg ctcccacttt cctttatgat ggatccagat tgggctgtgt tggagactgt 1138921 ccgccagcag tatatcgcct tcaccgtttt cgattaagca gatgccgtct tcaatgagga 1138981 tggtgccgta ttcccacttt cgttcctctg tatataacaa ttgtttccgt ttcatccatg 1139041 ctgtctcctt tttcttcatt cctctctttt ctttccaatt caagcctgtc ccatacaact 1139101 cttttatgga caaatcaact atctgcctat agatgcataa acttactaag gtgctgaaag 1139161 aaacgaaatt gttacgaaag aaacgggatt ggagctgatg tcacatgtgt ggaattacgg 1139221 gttgggtcga ttttaaaaag cagctcgtcc aggaaaaaca aacgatggac agaatgacag 1139281 acactctttc caaacgaggg cctgatgatt caaacgtttg gggggagcac catgttttat 1139341 tcggacataa aagacttgcg gttgttgata ttgaaggcgg acgccagccg atggcgtgta 1139401 cctataaagg cgatacgtac accattattt acaatggcga gctttataac acggaagatt 1139461 tgcgcaaaga attgcgggcg cggggccatc aattcgagcg tacgtcagat accgaggtgc 1139521 ttctgcacag ctacatcgag tggcaggaag actgtgtcga ccatctcaat ggcatattcg 1139581 ctttcgctgt gtgggatgaa aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg 1139641 taaagccgtt tttttacacg aaggaaggct cttcatttct cttcgggtcg gaaatcaaag 1139701 caatcctcgc gcaccctgat ataaaagcgc gagtggacag aacgggactt tctgaaattt 1139761 tcggtcttgg accgtccaga accccgggca ctggcatatt taaaggcata aaagaaatcc 1139821 gcccggctca cgcgctgaca ttttccaaag acggacttaa tatttggcgt tattggaatg 1139881 ttgaaagcga aaaacatacg gacagttttg atgacacggt tgccaatgtc agatcgttat 1139941 ttcaggacgc ggtgacgcgg cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag 1140001 gcggtctgga ctcaagcgcg attacagcga ttgcggcggg ccattttgaa aaggaaggaa 1140061 aagcaccgct tcatacttat tcgattgatt acgaagagaa cgataaatat tttcaagcaa 1140121 gcgcttttca gccgaatgat gacggaccat ggattgaaaa aatgacagag gctttcggca 1140181 caacgcacca caaatgcgtc atcagccaaa aagacctcgt tgatcatttg gaggaagctg 1140241 tactggtcaa agacttgccg ggaatggcag atgtcgactc atccctgctg tggttttgcc 1140301 gggaaatcaa aaaggacttt gtcgtcagcc tatcgggaga atgcgcggat gagattttcg 1140361 gcgggtaccc gtggttccat acggcagatg ttgagtctgg ctttccatgg atgagatcaa 1140421 cggaggagcg gatcaagctg ctttctgact catggcagaa aaaattgaat ctgaaagaat 1140481 acgtaaatgc caaatatgaa gaaaccttgg cagaaacgcc attattagac ggagaaacgg 1140541 gtgtggataa agcaagaaga cagctgttct atttaaatat gctttggttt atgacgaacc 1140601 ttttggatcg gaaggatcgc atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg 1140661 ccgatcaccg gcttgtggaa tatgtttgga atattccgtg ggaaatgaaa atgcatgata 1140721 atcgggaaaa aggcattttg cgcaaagcgc ttgagggcat tttgcctgat gacattttgt 1140781 atcgcaaaaa aagcccatat ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg 1140841 agtggctgaa aacgatcaga agccaaaagg actccgtgct ccatacctta ctggacagaa 1140901 aacaattaga tcagctttta gaaacggaag gctcctcctt caaggtcccg tggttcgggc 1140961 agctcatgaa ggggcctcag ctgatcgccc atcttgctca aattcataca tggtttgaag 1141021 cgtatcgcat tgatattgac gagaggtagg ttcaatacaa atgtgattaa aagccagaga 1141081 tgtatagatt taaataagaa ggatagatga gcagggaaat atatgctcta tctatccttt 1141141 tttgtacaac agcactatcg aattgccccc gcattccttc aataagaatg aataggtttt 1141201 aatgttctgc cgataaaact agctgatacc gggcttaact ttaattccct agcccataca 1141261 gaaagttgac caatatggtg aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc 1141321 gtatataaaa cacctgtctc ccaaggaacg cttacaagtt catcttttat ttgatctgaa 1141381 tgtgtttgta aaacatcaat tatttcagtt cggaatgtat ttgagagaga tttcacttta 1141441 ttgagtgttt gataatcagc gaactgaaca gcgatatctt cttttccttg gatagcacga 1141501 atccaactat attccacatc aataatatga aaaagggtat ataaaatatt ctctactccg 1141561 ccaagacgat ttttaagtaa ttcttcagtg gttagttgat gacaccaagt aaaccattga 1141621 tctctaacct gccagttata ttcaaaaaat ttcatcacta aactcactcc aatactatca 1141681 tgtatcataa caattagccc ttttttccgt gattcctcta ttaatgaagt gatgattgag 1141741 aaatgtttac attctacctg ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg 1141801 atgctgtgcg tcttgttact tttacaaagt aagaatcggc attttcttca tatacaatta 1141861 ggaaaaaaca tactagactt gaagaagcag tgatacatag gagtgagaaa atgaaagaga 1141921 taaaagaagc ttaccagcaa tgcggacaga ttgttggcga atacgcgcca gcctgtttca 1141981 aagcattatc atatctcccg ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt 1142041 gccacacggc ggccagtgca gacgaaaagg tattgcccgc atttgaagct aaagctgatc 1142101 atgtttacca aaggacaaat aacggtaaac aacatctatg gaaggctttt gatcatgcgt 1142161 atcggacctt tacattggaa agcgaacctt ttcgggagtt tattgccgca caaaaagaag 1142221 acgccaagcc gtatgatgac cttgatgaac tgctcatgta cgcatatcgg acgggcggtg 1142281 ctgccggatt gatgctgctg ccgatactga cacgccgaaa acaagatcag ctcaaacaag 1142341 cagccgtctc tctcggcttg gccatacagc tggttcgctt cttaagtgat cttggcacag 1142401 atcagcaaaa aaaccgcatt ccccgtcagg taatgcagca attcggctat acagaggctg 1142461 atctccaaaa aggcaccgta aataaagcgt tcacaatgac gtgggagtat atcgcttttg 1142521 aagcagaagc ctaccttgaa gagtgtcagg atgccttgcc gctatttccg cagtattctc 1142581 aaaaaacggt gaaagccgct cttcatttgc accgggctgt tttagaaaaa atccgggcga 1142641 agcagcacga tgtatttcaa tatcacttcg ctctcacaga gaccgaagtg aagcagattc 1142701 tgtctgatat ctaaaaaaca cccggccttg attgagccgg gtgttacgcc ataccttttt 1142761 gaatccagat acgtgagcgc catcttctgt acattaagat tccccggacc cattcatccg 1142821 cgataaaaga aatccaaatg ccggcaagac cgaaaccgag gtggatgccg aaaagataag 1142881 caagcgggag gccaatgccc cacattgaaa tcattgccat gtaaaccggg aatttcgcat 1142941 cccccgcggc ccgcagagag ttaatgataa tgacattaaa cgagcggcct ggttcaagga 1143001 taatggtcat ggcaatcaat aggcttgcag ttgctataat gtcagggctt tgtgtgaaga 1143061 gtccgatcag gtcttttgaa aagatcgtca tcaaaacaga ggtagccgca gcaattccga 1143121 gtgcccaata taagctcttc atgcagcgct cataagcggc atcaaattgt ttgccgccga 1143181 tataacggcc gattaagatt tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa 1143241 acatcgtaat attttgcgta tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga 1143301 taaaatacgt gactatcatt tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa 1143361 tgccgatttt cagcagcttg cgcaaatgct ctttatgcat atgaaagact tttttcagcg 1143421 acatcttcag ctggatgcgt ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc 1143481 gggcgataga tgtggacatg gccacaccgg caacaccgag aacaggaaag ccgaacaaac 1143541 cgaaaatcac aacaaagttt ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca 1143601 ttgtatcttt tgtgtagccg tagcttttta agatcgcgct gaatgtcatg attaaagcct 1143661 gaataaagga cagacctccg acaacttgta aaaagacttt cgcatcaggc atcagtgcgt 1143721 ctgataatcc catcatatga agcagaggga cagccgcgaa aaagacgacg gcgctgatgg 1143781 ccaggctgat gaagaagttg gcgccgattg acacataagc gacttccatg gcttctttct 1143841 tttgccgtga gcctagaaat tgtgaaatga taacggtcgt tcctgttgcg ataaagctga 1143901 acatcacgat aattaaattt aaaatctggt tgctgacgcc gactgctgcc acgctgttat 1143961 ccgagtattg gctgagcatc agtgtatcgg cattacccat aaacatatat aatgagacct 1144021 caataaagat cggccaagta agcgaaaata atgagaacgt tttgtcagcg ggttttttca 1144081 aagcagttga tttgaagaca gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc 1144141 aacgttttaa agtgtacctc catttcctta taataaaaag ggatagaaac gatacttctt 1144201 gtaaaaatcc gacttaaaaa ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc 1144261 gccttttccg gtatttatcg cagctgggga aggggttttt aaaaaaggag aaacccatgt 1144321 gaaacgtgta ttctccgtgt ttgatctgat atatgtcaaa cagggaacgt tatatataac 1144381 ggaaaatgaa acatcgtttt ctgttgaagg cggcgagtac atcttgcttt ctcccggtct 1144441 tgaacactac gggacgaagg gcagtgatga agcaacctcc tactattggc ttcacttcga 1144501 tgaacatcga tatgaattta cggcaaaggg aggcagcaac tggtctgagc ttcagcagga 1144561 aaaagggagc ttcgaagagc tggcccgcta cggattggcc ttgccgagaa aaggcaaggt 1144621 gcagcgcccg cagtttatgg cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa 1144681 ctctgatttg ccgctcagaa agcaaatttt atttgaggag ctgatgctgc atcttcaaaa 1144741 agaagcgttc caaataccgt ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt 1144801 acaggagcac tataaggaaa agacgacaat caaggatctg tcgctcgccc ttcactatca 1144861 tcaggattat gtgagccgct gcatgcagca ggtgctcggc gtaactccgg cacaatacac 1144921 gaaccgggtg agaatgacgg aagcgaagcg tcttttatcc tctacaaatg ataaaatggg 1144981 cgttattgcg gaaacggtcg gaatggaaga tccgacatac ttttcaaaac tctttaagca 1145041 gatagaaggc atttcaccaa ttgaataccg gaaaattgtc agccggaaag ttcaataacc 1145101 agacgaggga tgaacatgaa aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg 1145161 atcacaactg tgtcccgtgt gataaacaat acggggagaa tcagcgataa aacacggcag 1145221 aaggtcatga atgtcatgaa tgaaatggca tacacgccca atgtccacgc cgcggcgtta 1145281 acgggaaaac gaacgaatat gatcgctctc gtggcgcctg atatttcaaa tccgttttac 1145341 ggcgaactgg ccaaaagcat tgaggaaaga gcggatgagc tcggttttca aatgttgatt 1145401 tgcagcaccg attacgatcc gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa 1145461 aaggtggatg gcattatttt tgcaacaggg attgaaagcc atgacagtat gtctgctttg 1145521 gaggaaatcg ccagtgaaca aattccgatt gccatgattt ctcaggataa gccgcttctt 1145581 ccgatggata ttgttgtgat agacgacgtt cgtggcggat atgaggctgc caagcatctt 1145641 ctgtcactcg gccacacgaa catcgcctgc attatcggag acgggtcaac gacaggcgaa 1145701 aaaaatagaa tcaaaggctt ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa 1145761 tcacttatca tccagacgcg gttttccttg gaaagcggca aggaagaagc gggaaaattg 1145821 ctcgacagaa atgctccgac tgctattttt gccttcaacg acgtattggc ttgtgccgcc 1145881 atacaagctg cgagaataag aggcataaaa gtgccggatg atctttctat cattggtttt 1145941 gataatacga tactcgcaga aatggcggct ccgcccctga caaccgtagc ccagccgata 1146001 aaagagatgg ggcggagcgt catcgaactg ctggcagaag caatagaggg aaaacgaaag 1146061 gcgaaacaaa aaatagtgct cccgcctgag cttgtagtca gacattctac atcaccgctc 1146121 aacacatgag cccgctaatg agcgggtttt ttcattatga cagttgaagc caaaaaaaca 1146181 tattgcgtgt aaaccaaagg cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc 1146241 aaaatggcag agcggataga accgctgttt ttttagctgt taagagaaaa cgctttctca 1146301 aagcgagccc gaaatgagat aaaggagagg atgggacgtg gaacatcaag taagatgtgc 1146361 agtattggga ttaggaaggc tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc 1146421 gggggcaaag ctggtttgtg tcggtgatcc gttaaaaggg agagcggagc aggttgccag 1146481 agaactcggt atcgaaaaat ggtcagagga cccgtatgaa gtgttagaag atcccggcat 1146541 tgatgctgtc attatcgtaa cgccgacaag cacacatggt gatatgatca tcaaagcagc 1146601 cgagaacggc aaacagatct ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa 1146661 agcagcttct gaaaaagtta aggagacagg tgtcatctgc caagtcggct ttatgagacg 1146721 gttcgatccc gcatacgcag atgccaaacg gcggatcgac gctggagaaa tcggcaaacc 1146781 tatctattat aaaggcttta cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca 1146841 cagcggtgga atttttatcg actgttccat ccatgactat gatattgccc gttatttgct 1146901 aggggcggaa atcacttctg tttcaggaca cggcaggatt ctgaacaatc cgtttatgga 1146961 gcagtatggc gatgtggatc aggcgctgac gtatattgaa tttgactcgg gcgcagcggg 1147021 ggacgtcgag gcaagcagaa cctctccata cggacatgac atccgggcgg aggtgatcgg 1147081 gacagagggc agtattttca tagggacatt gagacatcaa catgtgacca tcctatcggc 1147141 taaagggagc agttttgata tcattccaga ctttcaaact cgttttcatg aagcctactg 1147201 cttggagctt cagcatttcg ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga 1147261 tattgatgcg acgatcaatt tagaagtggg tatcgccgca accaattcct ttcgaaacgg 1147321 catgccggta cagctagatg tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt 1147381 gcatttgagg ctttccgcaa aaaaagcaag ggcattttag cccttgcttt ctcttttctc 1147441 atataaatag tacatataat cagtaggtac gcctgaatgg tccagctgtc tcagcatggc 1147501 ggttacgttc cctctgtggt aagtgccgtg attgacgaca tgcaggatgg tgtctgcata 1147561 ggttgattcc agtgtaccta gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt 1147621 ctggcggctg aagaaatcat gatactgtga ctccagctcg gcagcgtgct gtttaatcgc 1147681 tgccatatta ccttgcgcgg actgtaattt gcctgcgctg tctataatct cttggtaggc 1147741 cactcccgaa agaacattca gccaaatgta gtcagccctg cacatatgaa gcagcacgtc 1147801 gctgacagaa ggaaatacgc tctttacttc ttgataggca gtttcctccg gcaggttttc 1147861 gatatgggta aatattttct tgtttgccca agaatgatag tcataaaact gttttgcatc 1147921 agtcatcagc atgccccctt ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat 1147981 tgcaaaagag tgacacccca aaatatcctg ccgctgccca cattaccgct gcagagcatt 1148041 tgtttacgat cagcataagc ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta 1148101 ttgcaaggct gatgaaccaa atccaagaca cagcgatgca ggcggccata aagagccatt 1148161 tctcaagccc cgaatattga agagagctcg tgccgatgac gccgatcgtg tccagaatgg 1148221 catgcgggtt taaaagagaa acagcggccg caaacgcagc ttgctttttt ggtgtgaacg 1148281 tatgtttctc attttggctt gtgttcggac ggatgttcca agtcacccag cccatataaa 1148341 gcaaaaataa aaatccgccg gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa 1148401 tgacagacac gcccgcaacg gctaatacaa ttaacaaggt atcgcagact gaagcactga 1148461 tgacagctgg gagagcccgc caaatatgct tttgcaacgc gccttgctga aaaataaaca 1148521 cattctgcac tcccagcggc aaaattaagc caaacgcgag cacaattccg tgaatgattg 1148581 cattcatgct gaaaaagctc ctttcacatt ttttttcaat cataagagag attgtcacta 1148641 aagtctccag ccatttggtt gggttaggaa ccagccaaat gtataatgtg taaaaaaggg 1148701 gggcatgacc ttgtcgcaat ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca 1148761 gatcgaacaa tatatgaaag acaagattct tcacggagag tgggctgtag ggacgaaaat 1148821 cccctcacag agaacgctgg ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc 1148881 catagatgaa ctcacgtctc aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt 1148941 tgtaaacagt acttggagcg tgctgacggc tgagcctccg cttgattgga gcgattacgt 1149001 ccgttcgggc attcatcgcg ccaattcttc catcattcaa gctattaatc agaacgaacc 1149061 aagagcggat atcatcagat taggaactgg agaactttca ccggatcttg tgcctgctga 1149121 cacaattgga cggatgtttc agcaaatcaa tccgggcgtc ctgtctttag gatatgagca 1149181 gccgaaagga aaccgtcagc tgcgggaggc agtggccgac catttaaaag gaaagaagat 1149241 ccatgtgtca ccgtctgcaa ttttaattgt gtccggtgca cttcaggcac ttcagctcat 1149301 ctcaattgga cttttaaaac gagattctgt cattttgacg gagaagccgt cctaccttca 1149361 atccttgcat gtatttcaat cagctgggat gcggcttcgc ggcttgccga tggatgatga 1149421 aggggtcaaa gcggggcttg tttcttctaa tcgaaaacaa tatggaggac agctgcttta 1149481 cacgattccg tcgtttcata atccgacagg cacagtcatg tcagagcagc gaaggaaaga 1149541 gatcatcagc ctgtcaaaaa aagagcagat gcccatcatt gaggatgatg cgtacggtga 1149601 tttatggttt gaagaaaaac cgccgcagcc gttgaaagca atggatcatg agggcaatat 1149661 tctgtatctg ggcgcgtttt caaaaacggt tagccccggt ctgcgaatcg gctggcttgc 1149721 cggtccggag ccggttattg aaaggctggc ggacattaaa atgcagacag actacggatc 1149781 aagcggcctg tcccagtggg cggctgccga gtggctgtca cagggatatt atgaagagca 1149841 tctgacttgg gtacgcagga agcttaaaga aaggagagac gccgccgttc attttctcga 1149901 gcggtatgcc ggggacattg ccacgtggcg gattcccgca ggcggctttt atatttgggt 1149961 gacatttcac aaaaacctgc ctgtcagccg tttcttttat gaattgctga aacggcaggt 1150021 gcttgtgaat cccggctata tttatgacgg tgaagaccga aacagcatca ggctgtcata 1150081 ttcctatgca tctcttggag atttggaaac tggcattaaa gcggcagctg aaacagcacg 1150141 ccgcctgatg atgtcctagg ctttggttat acgatgacag ctcccagtgc cctggcgaag 1150201 gcaatcgcgt gctcaggtgc gattttgcag cctttcaatt tgtcgaggga gacatgaagc 1150261 tgttcaaaac ggcacgtgct gatgtccatg ttttgaaggg acgtgccggt aaagctggcg 1150321 ccttccaatt cgcatccgtc aaagtgtgtc tgctggagca ccgtatcgct gcattcactt 1150381 tgcataagag cacagtgatc aaatcgaact tgtttcatat ttgagtacga aaatgagctg 1150441 aaatgtccgt ggcattcctc gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt 1150501 ccaaccattt ttgactgctt aactgaagtt ctgtgaatga cagccccgct gaaatcggcg 1150561 tttgataaat cgcatttttc aaagatcaca tcggtcagtt caatatgccg aaaagacaca 1150621 tcgataaaga cgacatttct gaataccgtt ttttcaacac atagtctttc gatatcttcg 1150681 ccgcagatgg tgcaatcttc aaacaaatgc atgctgatta catcatcctg tgtcacggca 1150741 tcatgaaaat ctgcggtttg caggttttcc ggtatgttcg gtttttgaat tgcgatttta 1150801 ttcatgtgat gacatccttt gctgcccgaa aaacagaggc ttccgggttc aatttaatag 1150861 atcgttaagg aaattgatac atatagtaaa tcgtgaagag ccttttcttg gtacagcagc 1150921 ccgcttgttt tgtaagcata aatggaaagc ttcctatacg tcaaggcgtt tacaggccga 1150981 aaaagccaaa gggaacagga ggaatgcgga atggggcatt acatcaaaac cgaggagcat 1151041 gtgacactgt ttgtagagga tatcggacat ggaaggccga tcatcttttt gcacgggtgg 1151101 ccgttgaatc ataagatgtt tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt 1151161 tttatcggcg ttgatttgcg gggatatggg caatctgacc gcccttggga aggctacgat 1151221 tatgacacga tggccgatga tgtgaaagca gtcatttata cgctgcagct tgagaatgcg 1151281 attcttgccg gtttttcaat gggcggcgca attgcaatcc gttatatggc aaggcatgaa 1151341 ggagccgatg ttgataagct gattttactg tctgcggcgg cccccgcgtt tacaaaacgc 1151401 ccgggttatc cgtacgggat gaggaagcag gatattgacg atatgattga attgttcaaa 1151461 gctgatcggc ccaaaacact ggctgattta gggaaacagt tttttgagaa aaaagtgtct 1151521 ccagagctta ggcagtggtt tctcaatctg atgctggagg cttcctccta cgggacgatc 1151581 cactcgggca tcgcattaag agacgaagat ctcagaaagg aacttgctgc aatcaaggtg 1151641 ccgacgctga tcctgcacgg gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa 1151701 ttgaagcgcg gcatcaaaca gtcggaattg gttccgtttg caaacagcgg gcacggagca 1151761 ttttatgagg aaaaagagaa gatcaacagt ttgattgcgc agttctccaa ctcataagaa 1151821 aaaacccgac attgatcggg ttttttatat aattcctctg ttttgcagtg cgttaatgat 1151881 gagatcagct ccatcggaaa tagaggtctg gtcagactca atgatgaaat cgggtgaaag 1151941 cggcgcttca tacggagaat cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt 1152001 tttataaagc ccttttggat cgcgctgttc acaaacatgc agcgggcact tcacataaat 1152061 ttcgaagaac tcacctttag gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg 1152121 agaaataaaa gccgttaaaa tcatttgccc gctgtcgaca aacagcttcg ccacttctcc 1152181 gatccggcgg atgttttcaa tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc 1152241 gtggcggata ttatcaccgt caagcacgta gctctgaatg cccttgcggt aaagcttttc 1152301 atcgacagca ttggccagca ccgattttcc ggagccggac aaacctgtaa accaaaggac 1152361 gcagcttttg tgtccgttta aggactgtct gtcagacttt gagatggcag cgggatgcca 1152421 aatgatgttc ggattgtgtg tcattgcaat tccccgctgt tttgcttgat ggcaacaggc 1152481 tgttggtgaa gtcccttgat cagcacggct gcgacctcag gccggctgaa ttctttaggc 1152541 ggctttttgc cttggcggag aagctctctc acttttgtgc ctgataagtg gatgtggtct 1152601 ctcgggctgt gcggacatgt tttggaggtg cccatgtttc cgcattttcg gcaataaaag 1152661 ctgtgctcaa aaaacagcgg cttgatgccc agctcttcct ctgtgaatga ttgaaaaata 1152721 ttttgggcgt cgtatgttcc atagtagctg ccgacacccg cgtgatcacg gcctacaata 1152781 aaatgggtac agccgtaatt ttttcggacg agcgcatgga aaatcgcttc ccgcggacct 1152841 gcataacgca tggcggcagg gaaaaccgat aacatgacac gatcctttgg ataatagtga 1152901 ttaagcaaag cctggtagct ctccattctg atatcgctgg ggatatcgtc tgactttgtt 1152961 tctccgacaa gtgggtgaag cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg 1153021 tattcatgcg ctctgtgaac agggttcctg gtttgaaagc cgacaatcgt cttccagccg 1153081 agtttttgaa aggccgctct tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg 1153141 tcaggcaggc tgctgaccgt gataggccct ccgatatagt aatccgggcg cgccagcaat 1153201 ttttttacgc ctgggtgggc aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt 1153261 ttatcaggct ggtatatatc ggtgactgtg atcatgccgt aggtaacacc gtctttcaca 1153321 agcttgacgt gatctccggc agacagctgt cttgctgttt tttctccgac aggcagcgta 1153381 atcggcaggc tccacggcaa gccgtttgcc agcctcatct ctttcacaac ggaatgataa 1153441 tctttttctc ccaaaaaacc tgttaacggg ctgtagccgc cgatcgcaat aagctccaga 1153501 tcactcagtg caagctgatc cagctctgct tggcacgcgc acccttcaaa atggcatgcg 1153561 ggatcacagc ggttgattaa tacccctccg tggggttcgt ttccattcaa cgtgttcaac 1153621 ctccatttat acgtttcctt gttttctttt ctgcacttaa tgaaagtttg acatcagcgc 1153681 cttaacatca tttcgattct cacatcaaga acctgccatc cgctattctt gatgcaggcc 1153741 gcattctgtt ttctcccgtc cggcccatct tccagccctc tcatcgttcg ggtccgggga 1153801 aggcagtgta cacatttcac agcctatgct cggataatgt tgatcgtgca gtttgttata 1153861 aggcaaattg tgcaggcgga tgtacgtcca aacgtcatcc catgtccagt ggataagcgg 1153921 gcaaattttg atgagctcaa acttctggtc caggtttacg tattgaatat gctttctcgt 1153981 tggtgactga tcccggcgca gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt 1154041 gagcggttcg attttccgca attggcagca gaggttcggg ttatgcttcc acagctctcc 1154101 gccgtacttc gtcccctgtt ctgttaagct cagctcgggt tcgagcatct ggattgcaaa 1154161 tcccggatat cgttctttga cggtctcgat cagctcatat gtttcctgaa aatgaagccc 1154221 ggtatccaaa aagatgatgt gtgcgttttt gttgattttt gatattaagt cgagaagcac 1154281 cattccttct gcgccaaagc tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc 1154341 ccatttcaac acatcgagct catcgatcaa ttgatccgtt atctgtttgg acagcatgtc 1154401 gttccaagtg tcatatgtga tggtttcgtt caatgttttc cccccgtttg catctgcttt 1154461 ttttatctat tgatcgagtt ataggcagac tattcatttt ttgcataaag gttcaggttt 1154521 taggtgccgc gcccgcctaa aatgaggtgc ggaaccatta agagcccggc tgaatatgct 1154581 ttttagcaaa atggttttat gcccaaggag aggtagtatg ccgattgcca tttatcaggg 1154641 gcatcatcat tcgcttgccc cggcggacat taacatcgtc attgatgtca tcagagcctt 1154701 tacggtcgcc cattatgcgt ttatcggcgg ggcgaaagag attttgttgg tccggacagc 1154761 tgatgaagcc tttgcgctga aagacaccta tccggattat gttttgacgg gagaggaaaa 1154821 gggggtcggt atcagcggat ttgatttaga taattctcca aaacgtatgg ctgggcagaa 1154881 tatgacggat aaaagcctga tccagaaaac aacaaacggc gtcacagcag cattgggggc 1154941 gctgaacgca aagcatctgt tcgtaactgg attttccaat gccaaaacaa cggcacagca 1155001 tgtgaaaaag ctcgtcgcaa acgattgtgt cataaacata gtggcttccc atccatccgg 1155061 tgatgacgat atggcatgtg cggagtatat caaaggcatc attgaaggga caaatgtggt 1155121 aacggctgcg gaggcgattg aaagaataaa aggctcttct gttgcggaga agttttttga 1155181 ctgccgccag ccattgtttg attcggaaga catcgtttac tgtacaaaag aactgacggg 1155241 cgatttcgtg atgaaagtga aacaagatgg agaagttcca acgatagaga gggtcataat 1155301 atgaatgatt tttcactaga attgccagtg agaacaaaca agccgagaga aaccgggcag 1155361 tccattttaa ttgataacgg ctatcccttg caatttttca aagatgcgat agccggagcg 1155421 tccgactata ttgattttgt gaaattcggc tggggcacat cattacttac gaaagatctt 1155481 gaagaaaaaa tcagcacact gaaagaacat gacattacat ttttctttgg cggcacactg 1155541 tttgaaaagt acgtaagcca gaaaaaagtg aatgaatttc atcggtactg cacctatttc 1155601 ggctgtgaat atattgagat ttcaaacggt acgctcccga tgacaaataa agagaaagcg 1155661 gcttacattg ccgatttttc tgatgaattt cttgtgctca gtgaggtggg cagcaaggat 1155721 gcggaattag caagccggca aagctctgag gaatggcttg aatatatcgt tgaggatatg 1155781 gaagcgggcg cggaaaaagt gattacagaa gccagagaaa gcggaacggg agggatctgt 1155841 tccagcagcg gcgatgtcag gtttcaaatt gttgacgaca tcatttcctc ggatattgat 1155901 atcaacaggc tgatttttga agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa 1155961 atcgggccga atgtgaatct tgccaatatt ccatttcatg atgccatcgc gttggaaacg 1156021 ctgcgtttag ggctaagatc cgataccttt tttctgtaaa atagcggctg cggggctctc 1156081 gtcgtgaaga gagcctctgc ctattatttt ttatggcggt acataggcgt gagataggga 1156141 agtgaggtca ggcggatgtt gtagatgaag tcgatgactc ttgtcgatat cacctggcat 1156201 atgagggctt gaatgacgat gccccagtca ataatagacg cggtgaccat aaaaatgatg 1156261 caattcatga tgagcaggat cgttccagga ttcccgccgc ggtagataga aatcatcaga 1156321 gcaagggctc cgaatcctcc gttcgaaatt ttatatttgt ataaaagtcc gattccgagt 1156381 cccaataaca ctgcgccgct tgccagatca agccacaggt tagatgtgat atcaggaaaa 1156441 actgcatcaa agatcaatac cgagacagag gtgacggtga tagaagcgag ggtgccggtg 1156501 aatgttctca tctccagcca ttttaaagcg gtaaaaagca ttgatacatt cacagcccac 1156561 actgaaaatc cgtgggggat ttgaaacaga taatgcaata gcaccgcaat acctgctgca 1156621 ccgcctgtcg gaatatcatg cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg 1156681 ccgcctacga caatcataaa cgtaagtttt gctttcatca gcagttcagc cattaagtca 1156741 tttgctcctt tatgaaaaga cttgtccgct gttttcattt tatgaggctg tccattattt 1156801 atgtctcaaa ataaagaaat ggcccagctt aataggctga gccatcccac ttgtagcgat 1156861 tgacgatctc catattgatc tctgtgccaa tgccttttcc tttcgggatg tggaccattc 1156921 cttttgaagg ctgcaggctg acgagatctg taaaaggatt ctccatgacg tcccactcga 1156981 tcggttcaat gtgatcgttc ttcattttag accatggggg cagacaggct tgtgcaaata 1157041 aagcatagag ccgtgagagc gatccgtcat atgcatgggc ggatgctctg acgccgaaat 1157101 aacgcgcgag ctggaggcag tcccgaaact catcaattcc gttgacatgc atgacatcgg 1157161 gctgaatgat atccaaacag cgctgtgaaa ggagaggcac atattgcgcc gggcctttca 1157221 tgttttctcc gccggcaaca ggaacagaca aacggcttcg aagcatagcg taatcctgcg 1157281 gctgatcaaa gggcaaaggc tcctcaagcc agccaatgtt cgtccattcg gagaaatagc 1157341 gctcccattt aaaagccgca gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa 1157401 tggagctgcc tgctgtatgc tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag 1157461 tcccgccaat tttgactttg atttgctcaa aacctttttt caactgggct tcaacattgg 1157521 agactgagcg gctgatccat tgcggggagt ctgagtacga ttgaaaagac gcgtacacag 1157581 gaatctcctc tctgtatcgc ccgccccata attcgcaaac cgaacaatcc gcagctttgg 1157641 ctgcaatctc tgtcagcgcc atgcttacag cggaggccgc ccgctggtgc catttttgaa 1157701 tcgtgcgcac taatgacagg cggctgccag cctgttttcc taatagaaat gggatgatcc 1157761 gcttcgtaaa accgacatgg agagcaggga gccaatcaac gcattctccc cagccgtcta 1157821 tcccgctttc ggtgataatc ctgatgagat aacaagtccg atatcgttta aacccattgg 1157881 catctccgta tggcttttct aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt 1157941 tcacactggg tgctaccttt cctcagcggg ctggagccga ttgccagcca ttttagggtc 1158001 ttctttttct tttgtttctt cattgttttg cttcacatgg atgagcatca tcacaagaat 1158061 cccgacaacg agagtcaatc ccgcgatgct taaaaacatg ccgggtctgg accattgcat 1158121 caggcggccg aaaatcggag gaccgatcgc tacccctaag aaacgtacag agccgtacag 1158181 cgaggtgaca aatccccgtc tttctttgcc gacagccccg gtaatgaaac tgttcacaca 1158241 aggaaggaca agacctgagc ctatactgct cagtacaaga acactgataa aaaggacaag 1158301 attttcaatg aatgacagtg ccgcgtagga tacggtcatg aacgccaatc caagtacgat 1158361 cagctttttc attaacgatt gcttttgccc gattttgctt cctgttgtat aggacgtcac 1158421 acacataacc aaaagcggga tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta 1158481 tgttttttca agaacatctg agagataaaa caggatgccg aataaagtaa acaaacaggt 1158541 cgcaccggct aaataagcgg taaacagcca tctgccttca tgtttaaaga cacttaacag 1158601 cccttttgca tattgtccga ttggtggcgg ttctttttcc tttttctttt ctttaataaa 1158661 aatccaagtc agtacgatcg aaatgataca aaacacagga aaggcaaaaa acgcgccata 1158721 ccagacaagc agggcgatca gcgagccaat gatcggcgat agcactttcc ccatgccgtt 1158781 tgaagcttca acaaggccga gcaccttgct ctcctgggcg cctttaaaca gatctcccgt 1158841 cagtgccatg gcaattgggc cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc 1158901 catgacccaa ggataggcat tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc 1158961 ggcaccatac aaaattaagc agggaataat gatgactttc cttgagaatc ggtctgcgag 1159021 ataaccgaca atcggaatcg caaatgctgc aatcaaggaa aatactgtga tcacgagact 1159081 gacttgaaat tgtgataaat gaagttcaga tttcattttt ggcaaaatcg gaataagcat 1159141 cgagtttcct agggttaata ttaaagggat tgaaccgatt gccacaatcg tcattccgtt 1159201 attttgtttt gatgattcca tctcagagca cactcctttt cttctgctta gaatgtccct 1159261 gatggcttcg tttattcagc gatcagacag caaaaaaccg aacagaagat acctgttcgg 1159321 gaaaaaagag ggttaaccga gagcctgtga aatcaaagca tataagtgtc cattttgaat 1159381 aggcgctttt ttctgataga acaaaatcgg aggttcatca tctttatgaa atcccatttc 1159441 tatcaggctg tcatgcagag acgtgtgttc actcggtata tcgattcgca tcggcccttg 1159501 tttgccggcc gccagccttg taattatctg tgctgcaaca tctgatgatg gagcgatgat 1159561 agggccgaat ttcaaattgg ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc 1159621 gtcctgattt ctggcgatga tacattcgca tgaagcagaa ataagctgct gcaaaaggtt 1159681 tgatcgatct ccgccaaagg cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc 1159741 tctaaaggat gtcagttcag catcaagctt ttttgtataa ggttgaaaac tgtgacagct 1159801 gtactttcgc actgaacctg ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc 1159861 ttttgtggcg caaagcctga tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac 1159921 catacgccgg ccaagaccga gccgttgata ttccttgtca acgataacaa ggccgataga 1159981 agtaagacgg ccaaacaaaa acaagccgat gcaggaaata atatcaccgc tgacattttg 1160041 ataaccgaaa aagcgtccct gctgaacaag cagtttcagc tcttgttcgc cataatccgg 1160101 ccacccggct tgcccgcaaa gccgcaataa gccggaaacg tgttcttcat gaagcttaat 1160161 cagttcatct actacgtcca taagatcacc tgcttgttct aagtgttttg tacatgacaa 1160221 tatgattgcc aatgccggga atgtcaaatg gttcgccaag ttccttccag ccaagcttgg 1160281 catagtagcc cttgacatgg tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg 1160341 ccagtttgtg ctccgcgtgt ttgatcagcg tgcttccagc tttttgatcg cgatatccct 1160401 cgagcgttgc catgcctctc agccgatacg cagaggcttc cgttaataaa ggctgacttt 1160461 gcggggaaaa agaagcgatg ctgatcagcg ttccatcata aaacacgccg agatgaaagg 1160521 agccttctgc gtgatcctct ttatatttgc attgttcgat ggattgatgg ggacgcagaa 1160581 tgcgatgccg gatttcatat gtatcttcca cggaaatggt tttgacttcg agcataatgt 1160641 tcctcctcat gattgttttt ctatatcgta acacgaatct cgttgaaaaa gactgcccga 1160701 ttcgatcagg cagtcttttg gaaattaatg caaaaagata ttttggcgct gctcatcttt 1160761 ttgctgaata tatgatgtga gctcagcggt taagtcagat ctgaggaaag gcgttatcaa 1160821 gtagatgccg ttaaacagct cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc 1160881 ttccgccttt tgcttttctt tatcttcacc ggcatgggcc attttttcgc gaatcgtatc 1160941 agacagctta atgccgggaa tttcattatg gatgaattcg gcattccggc tgcttgtcag 1161001 cggcatgatg ccgatataga tcggcgtctt cagatgtttt gtttcgttat ggatatcgac 1161061 aagctgctgc tcggaataga caggctgaga aacaaaataa tctgcgccgc aatctatttt 1161121 tttctcaagc cgttttaccg ctttatccag atggcggacg ttaggattaa atgcggcggc 1161181 aactgagaaa ttcgttttct tgccgagcgg ttttccagac agagacagac cttcattgaa 1161241 ttgtttgatc agcctgatta aatcaaaaga tgttaaatca tatacagacg tcgccccagg 1161301 aaaatccccg attttagaag ggtcacctgt aatagcaagc acgtcattca gccctaacgt 1161361 atcaaggccc attaaatgtg actgtaagcc gataatgtta cggtcacggc acgtaatatg 1161421 gacaagggaa cgcatatcga gctgctgctt gacaagggcg ccgcaggcaa cattgctgat 1161481 ccgcggggtc gccaaagaat tgtcggcgag tgtcagggca tcgattcccg cttcttttaa 1161541 ttcagcagca gcggacagaa atttgtcaaa gcttagtttt ttcggcgggt ccagctctac 1161601 gataatagag cgttttttcg ctgcgatctc atccaggccg ggctcggttc gctcgtgatg 1161661 aacagaaatg aattctttcg cccgggtttt gacttctttt tccgtaatcg gagccagccc 1161721 gccaaccgct tccgccatcg ccctgatgtg attcggcgtt gtgccgcagc agccgccgat 1161781 aatccgcgca ccttgcttac ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt 1161841 ttcatagacg agccgtccct cttcaagcga aggaagactg ctgttcggat aaacggataa 1161901 gaatacgtca tcaaaaatcg gcacttcgct tagcgcttca atcatgtgat aagggccgag 1161961 gcggcagtta atgccgacaa tatcagctcc gagatccgca atcgagcgca atgcgtcaga 1162021 aagcggcgtt ccgtcctgca atacgccttg ctcgtgcatg gagacattga gcataatcgg 1162081 aagatcagtc tctttgcgcg cgattttcag cacttcacgg gcttcttcca aatcataata 1162141 tgtttctaac agcaagccat ccggctcttc atgcagcagc agatacagct gctcgcggaa 1162201 gctgcgctta atttcgtcaa gactgtatgc gtttttatta aatgtgcgta tgccgcccat 1162261 cgttccaagc acgtatgcat cgcctgctga agcccgcgcg atctttacgg cctcctgatt 1162321 catttttttg atgtcatcct caagcccgtg tctggataat ttaatatagt tggctccgta 1162381 cgtattcgtt tgaataatgt tggctcccgc ttcaacgtac gctttatgta tgcgctgaat 1162441 ttcctccggc tttgaaatat tgagctcctc aaaacacctg tcaatgccat aggagtagag 1162501 gagcgtcccc atggcgccgt caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc 1162561 cattgtctgc ctcctttatt cacatcagca aggaaaaaag agaaataaaa aaagtcctct 1162621 taagaagaag actttgtcag tgattttgtc tcttcttatc ttccaagctg ttcgagcttg 1162681 ctggatttag caccttggtc atggctgatc gccattacac cggttgctga agcttcgtcg 1162741 ggccagtccc tctgcttctc ttgataagaa cggatatgaa attttcgtgt caggaagtgc 1162801 caaaagatat ctggcgtttt tccctttctc caaatttacc gaaaataaag acaataatca 1162861 ataggaatca gaaaatttat ctgaaattta taaattgaac gtcaattggc agatctgctc 1162921 cccgtacagc tgagataatc tgctgcaggt catctttgtt ttttccggtg acacgcactt 1162981 gatcatcctg cacctgagac tttactttca gtccggagtt tttgatgatc gtattgattt 1163041 tttttgcgtt gtccttgtca atgccttgaa caagctttgc acgctggcgc accgttccgc 1163101 ctgacgcgtt ttcaaccttg ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca 1163161 atttgctgac cagcacatct ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga 1163221 ccagctcctc tttatctaaa gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac 1163281 tgatttcctt cagtgcgatt tggattgcgt tttgcacttc aggcaattcc accttggata 1163341 caatatcaaa tgaactttct tttgccatat gaaaacctcc ataacattta acttatgtgt 1163401 tgattatagt agaataaaga gaaacttcca acagaacaaa gaatcaattt gtgatgattg 1163461 gaaaaaatgt taacaaaatc cgcagagaat aagcggaaca ggaaggacga tagcatgaga 1163521 ccagggcagc aattaacctt gagtatagat caccaaaccg acttcggtta ctttttaacc 1163581 gatggggaag atacgattct cttacataac agtgaaatga ctgaggatat cgaggacaga 1163641 gacgaagtag aagtctttat atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa 1163701 attccgatca tcagcgcgga tgaatatggc tgggttgaag tggtggataa agtggaagat 1163761 atgggcgttt tcgttgatgt cggtttatcg aaggacgcac tagtcgcaac tgagcatttg 1163821 ccgccgtacg aagatgtctg gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg 1163881 acgaaccggg ggcgcatgtt tgcgaaacca gcgccggaag atatcatcag cgaactgttt 1163941 accgacgctt cagaagatct gatgaataaa gagctgacag gtacggtgta caggctgatc 1164001 gcatcgggtt cattcgtgat cacggatgac ggtatccgct gttttattca cccgtcagaa 1164061 agaaaagagg agccaagact gggttcaaga gtcacaggcc gggtgattca agtgaaagaa 1164121 gacggttcag tcaacttgtc gctgcttccg agaaaacagg atgcaatgtc agttgatgct 1164181 gagtgcattc taacgtatat gagaatgaga aacggtgcca tgccgtacag tgacaaaagc 1164241 cagcctgacg atatcagaga acgttttaat atgagcaaag ccgcctttaa acgcgcgctg 1164301 ggccatttga tgaaaaacgg aaaagtgtat caggaaaatg gatggacata cgagaaaaaa 1164361 tagcatgaaa acggctcgcc tgcagcagac tgcggagcga gccgtttttt tatgtctagt 1164421 ttaattcatc aaccagcgtt ctgattgcca tttcgcgatc cacattgtct gaaatcgcaa 1164481 tcggcgtaat atcaatggcg agaatgatca gaatcagggc acctgctgca gcaacataag 1164541 aaacataata gaaatagtta gcggtatcaa cagtgttgac aagctcggcc tgaactctgg 1164601 atgtatcatc cttagaagcg gcgatttcct ttgcagcttc tactttttct tcaacgattt 1164661 gacctgcttt tttcagcagt tcatccactt tcaatgcatc tttgctgtaa acagctttct 1164721 tcaggttatc aaaaaagtca gcatcctctt ttttaatatc agcgacaacc tgattggcaa 1164781 aagcctttgc ctgttttgtg ttgagtttgt ctgtcatcgc tttattaaag acctctggaa 1164841 gctgtttgcc aacttcccct tgggcaaaca caaagccttt aaaaatttcc tcacctgaat 1164901 actcaagctg ctttgcctgt gccacacttt cttgctgctt caccaaaaac acagtcgtca 1164961 ccaatacaac cgacaaaaat actagaaacg ccttcttcaa actgaaacct ctcccttctt 1165021 gtgtttttta ttccacaaca gtctgcgaat atatgtaaat tgaatcgtgg aatcgatagg 1165081 agtgagatac aatatcaaaa tgccggccat gataatcgaa aaactgatga ggcccagcat 1165141 gactgcaaaa atctcatgca taaaaacagc gatgatcaaa atcaatctcc aatgcttctt 1165201 cggcgcaaac agtgccgcga agatgacaat ttgaaccagc agcgtccccc atgtcggaat 1165261 caccacgaac ggacttgtta caattggctt cgttaacgcc tgaaaaaagc cgttgaagcc 1165321 aatggttttt tcctgggcga aataatagac ggccgttccg tccacccatt cctgctgaga 1165381 tagcttagcg acggtagagt gaaaataaag caccgccact tggattctga tcacaaaata 1165441 agaaataaaa gctgttattt ttccaagtgt tcttttgccc tctataggtc tcgtactcca 1165501 atgccatttt ctcggatcgg tcagcgtgat gggaagcaat aaaaaggtca tgactgctgc 1165561 tgcctgctcg cctccgtcga tgacgatcag cgatgactgc aggctgtaac tgacatacca 1165621 atgcagaacc ccggtgattc tggggcgcca gccaatgaca acaagcacca gaatggcaat 1165681 gcagacccat ctgaaaagat ttaacatcat atagttattt tcgccgagac aaaagagact 1165741 gagattcatt ttacaagctg gatagctgct gatcccgctg gctggcttca taatgaggct 1165801 cgggtgattg atgagcagcg tcagcaggct ggatagcgca atgatgcttc gcgcgaggcc 1165861 atatacattt gtccacgggt ttctttcgtc ccatctggtg atggtctgtt ttatgttttc 1165921 gagcatgaga tcacaacctt gactatgctt tttacctgat aagacgaagg ggtatattta 1165981 gaatagctcc aaggaacaat atcctctttc gtcaaatagt agctgccaca aagcagcggg 1166041 cggggagcgg gtgtttttaa ttgcacggtt ttggctttgc ttttgcatgc gccgaggtcc 1166101 ttttctttac atgctgtcca ctgttccttg ccgacttggc tgtagatcac gcccatttca 1166161 acgccttgtg accgcccata ccgatacagg ccgaataggt tgtcagccct catattgggc 1166221 catctgacct tggcgctggc attttcagcc tcatataagc cgattgcagt atcacgcgga 1166281 tttttgctaa aaaagcccca gccctgaggg aggatgctgg acatgagaaa tttggagtcc 1166341 tttgtcagcg gaatcggggt tgtccctaag ctgccaataa tagaaaacag aaatagcgaa 1166401 ccccaaagga ttgaaaaaat gacaaaaaat gatatcgatt tctgcattcg actgctcctt 1166461 ttaacctgaa gaatcgtttt tacacttttc ataatataaa aacatttatg taataaaaag 1166521 gttaaaaagt atgagaaatt ccatttttgt taaaaggaaa aacaggacat tttacactgc 1166581 tatatgtgat tgatatatag tgtttttttc gatatattta aaccatgaaa acgaatcaag 1166641 ttaatgaccg ctggattgtt caatttcgaa aagggatttt cgagctggcc atcctatccc 1166701 ttctgcgttc taaaccgatg tacggttatg agctgacgtc atccttaaaa accacctcgg 1166761 cgctggctat ttcagaggga gcgatttatc cgattttgaa acgtatgacc gagaagggat 1166821 ggatcgaatt tttttgggaa gattcactgg acggcccgaa aagaaagtat tacaaaatga 1166881 cgcaaaaagg agaagaaatg ttaaaagaac ggctggagaa atacctggaa acccatcaag 1166941 ccttactgtc tttatcgggg gatttgctat gaatggacag cttatcattg accgatacat 1167001 ggaggaacta aatgcagagc tggcgaatat gcctgatgta gagagagaaa acgctatcga 1167061 cgaattaaag gggcatatca ccgctttcgt tcaagacaga atcaaagccg gccttagtga 1167121 agaggaactg caggaagctg ttgaatctga attttctcat ccgaaggagc ttgccgaatt 1167181 gatgatgggt gatgggggag agacgaaaag gaggaggtct ttattgggca aaagctggat 1167241 ttcggtcctt ctcattgtca cgattatcgc cctgccgctg ctgccgtccg acttcagaca 1167301 tctgccgctg gctgtttatt taatggtgct cgccggatat gtatggaagc ggaaaaaatt 1167361 ggtgatgttt gcaggtgtca gaaaaaacaa aatgcgctct caaaaggaga ttgtcaagat 1167421 ttcgcgagtc ggtgcggttt atctgctgtt tttagcagtg gtgctccttt tgagcccgtt 1167481 cctcaatgcg cttgtcgtcc tgctgctgat tgcagtaagc tgcgccgctt tttttctttt 1167541 tcttaacatc aagtaatctt gtaggaggct gtaagatgga aatcagcatc aattatctat 1167601 taattgtcat cgcgctttta ttctttgtgg ttgcctattt tgtcggaatc aaaaaacaaa 1167661 cctggatgtt ggctgggttt aacgaggcgc gtatacggga taaagatcgg ctggccagaa 1167721 tagcaggcta ctttttcttg aattccggtt tgttcatttt gctgaatagt tttatctcat 1167781 ttcaaggtca ggagcagctc atacctccgc ttatactggc atatggagca ggggttatta 1167841 tttatgtcaa taaaaaatta gtagagtaga aaaagaaggg cagagcgaaa tatctctgcc 1167901 cttctttttt gggaaaataa gaacgaagca ccacatacaa gtttttgtat ttttgatagg 1167961 atgaagaaaa atggtagatt ccaaaatagg aaggatgtgg tgttttgcgc aacttgacca 1168021 agacatctct attactggcc ggcttatgca cagcggccca aatggttttt gtaacacatg 1168081 cctcagctga agaaagcatc gaatacgacc atacgtatca aaccccttca tacatcatcg 1168141 aaaagtcacc gcagaagccg gtacaaaaca caacccagaa agaatcgcta ttttcctatc 1168201 ttgacaagca tcaaacgcag tttaagctca aagggaatgc gaacagccat tttcgcgttt 1168261 cgaaaaccat aaaggatcca aagacaaaac aaacgttttt taaattaacg gaggtttaca 1168321 aaggaattcc gatttacggc tttgaacaag cggtcgcgat gaaggaaaac aaacaagtga 1168381 aaagtttctt tggaaaggtg catccgcaaa tcaaggacgt ctccgtcaca ccgtctattt 1168441 ctgagaaaaa agcaatacat acagcaaggc gtgagctcga ggcttccatt ggaaaaatcg 1168501 aatatcttga tggggaacca aaaggcgaat tatatatcta tccacacgac ggtgaatatg 1168561 atctcgccta ccttgtgaga ctctcgacat ctgaacctga gcctggctat tggcattatt 1168621 tcatcgatgc caaaaacgga aaggtcatcg agtcctttaa tgccattcat gaagcggcag 1168681 gtacaggaat cggcgtgtca ggtgatgaaa aaagctttga cgtcacagaa caaaatgggc 1168741 gcttttattt ggctgacgaa acaaggggaa aagggatcaa tacatttgac gcgaagaacc 1168801 tgaacgaaac cttgtttacg cttttgtctc aactgatcgg gtatacgggc aaagaaatag 1168861 tcagcggcac gtccgtattt aatgaacctg cggctgtaga cgcacacgca aatgcgcaag 1168921 ccgtttacga ttattacagc aagacatttg gccgtgattc ttttgatcaa aacggagcaa 1168981 ggattacgtc taccgtgcat gtcggcaaac aatggaacaa tgctgcgtgg aacggtgtcc 1169041 agatggtata cggggatgga gacggttcga aatttaagcc gctgtctgga tcgctcgaca 1169101 ttgtcgcgca tgaaatcaca cacgcagtca cacagtattc cgccggtctt ttatatcaag 1169161 gagaacccgg tgcattaaat gagtccattt ctgacattat gggcgcgatg gctgaccgtg 1169221 atgattggga gatcggcgaa gatgtctata ctcctggtat tgcaggagat tcattgcggt 1169281 cattggagga cccatctaag cagggaaatc cagatcatta ctcgaaccgc tacacaggaa 1169341 cagaggatta tggcggagtc catatcaatt cgtccattca caataaagca gcttatcttc 1169401 ttgcagaagg aggcgtgcac cacggtgtac aggttgaagg gattgggcgt gaagcaagtg 1169461 aacaaattta ctatcgggct ttaacatatt atgtaacggc atctacagat ttcagcatga 1169521 tgaagcaagc ggcgattgaa gctgccaatg atttatacgg tgaaggctcg aagcaatcag 1169581 cttcagtcga aaaggcgtat gaggctgtcg gcattctatg agcaaacaaa aacagtcagg 1169641 acacagagtc tgactgtttt tgtttgctca ttttcttaaa aagaatatcg ccaatgtacc 1169701 tggaccggca tgcgagccga tggctgaact gattggatgc ataatgattt ctttcggctt 1169761 gaacgcttcc tcaatcaggt gtttcatatc cgtggctttt tctttgttcg cggcgtagct 1169821 aatcccgacg gtttgattgc tccaatcatc cccgcgctct ttcataagct cgatgatccg 1169881 tttgaaaagt ttcttctgtc cgcgaatttt ttccagaggc acaagcttgc cgtcctccat 1169941 ctgaagcagc ggtttaatat tcaacaggcc gccgacaaaa gcggacgttt tggatatccg 1170001 gccgcccctc gcgagatatg ttaaatcatc aacggtaaaa atgtgttcaa gctggctgca 1170061 aaagttcttt acagacgttt caatttcttg tattgtattc ccgttgatac agagatcggc 1170121 agcatgccgg acagccagac cgtatcctaa tgaagcgcat ttggaatcaa tgacccgcaa 1170181 atcgaaatcg gggaattcct ccttcacttc attggcgatc attacagctg tctgatacgt 1170241 gccggagaga cctgaggaaa aggcaatgta aagagcggga tcacctgttt cggcatattg 1170301 caaaaacaca tttttaatcg tttgcggtga ggcttgggac gtcttaggcg tttctccatt 1170361 ttgcatcgct tcaaatattt gatccgcatg aattgtgact gcatcttcga attctttatc 1170421 gccgagagaa accctgagcg gaataaagcc aatgcctttt tcttcaaaat aagaacgagg 1170481 caaatcagtg gcgctgtcag cgatgagatg aactgtcata ttgcttccct tctttccgtt 1170541 atcgctcgtt atcatgagag ttaagccaac tatatcatat taatttgcca aaatcgtgtt 1170601 caaatatttg ttttaaggga aaacataata aagaagaaag agcggaggaa catgccatgg 1170661 tactagatca aacaaaaaaa ttactcatcg tcatcatcgg cgctttactc aatgctgccg 1170721 ggctgaactt atttttgata cctgcagatg tatatgccag cggatttaca ggtgttgccc 1170781 agcttttatc aagcgtcgtt gatcaatatg ccccctttta catatcgacg ggaacgctct 1170841 tgttcctctt aaacattccg gtcggtattt taggatggct gaaggtcggc aaatcgttta 1170901 cagtgtacag cattttaagt gtcgcactca ctactctgtt tatggggatc ctgccggaaa 1170961 caagcctgtc acatgacatt ttgctgaacg cggtgttcgg cggcgtcatt tccgcagtcg 1171021 gtatcggctt aacattaaaa tacggagctt cgacaggcgg gcttgatatc gtcgccatgg 1171081 tacttgcaaa gtggaaggat aaacccgtcg gcacgtattt cttcattctg aacgggatta 1171141 tcatcttgac ggcaggatta ttgcaaggtt gggagaaagc attatatacc ctggttacac 1171201 tatatgtgac aacgagggtg atcgacgcca ttcacactcg ccacatgaag cttacggcaa 1171261 tgattgtgac gaaaaaagcg gacgaaatca aggaagccat ttacggaaaa atggtgcgcg 1171321 gcatcacaac tgttccggca aaaggagcat ttacgaacga acagaaagaa atgatgatta 1171381 tcgtcatcac gaggtatgaa ctgtacgatt tagaaaagat cgtcaaagaa gttgatccaa 1171441 aagcatttac gaacatcgtt caaacgacag ggatttttgg tttctttaga aaagactgac 1171501 gaaagcaggt ggaagtcgtg aaacggctgc ttgtgatgct cctccccgtg ctgcttttga 1171561 taggctgcgg gaaagatgag cagacagaac ccgataagga ggtatcaggc ggaatggaga 1171621 atcaagaggt tgttttatct attgacgcaa ttcaggagcc tgaacaaatc aagtttaaca 1171681 tgtcgctgaa gaaccaaagc gaacgtgcta ttgagtttca attcagcaca gggcaaaaat 1171741 ttgaacttgt cgtgtatgat tctgagcaca aagaaagata ccgttattcg aaagaaaaaa 1171801 tgtttacgca ggcttttcaa aacctgacgc ttgaatctgg agaaacatat gatttctctg 1171861 atgtgtggaa ggaagtccct gagcccggaa cctatgaggt aaaggtgaca tttaagggca 1171921 gggcggaaaa tctcaagcag gttcaggctg ttcagcagtt tgaagtcaaa taagaggcta 1171981 tggcgagtcg ccatagcctt tttttattgc agtttgtcca gctgattttg aaattgatgc 1172041 aactgttgac gttccgcatc tgtcgaattg gcatacgcag aagatacagc atttttggct 1172101 ctcagaatcg cttgctcctg atcgccttcc tcaaagccgt ttgtcaccat gaccgcctgt 1172161 tgaacaaatg attttgcctg ctgaaacagt tcatttctca tttaatattc atactgcctt 1172221 tcagccgagt ctcgtgccgc ggcatgctgg tgagcttctt ctaaagtaga ccgatatgga 1172281 aatcttgcgg cgtgtagccc gatggagtct ttaccctgct gaataaacct tctggatttg 1172341 cttcgtttac ccattttgag actgccccct tccatacttt gacgagatga gtcgtcttca 1172401 atagtatggt ggggtaaagt aaggtttatg agtgggaaaa attaatacgg accttcttta 1172461 aagtgagaaa tattctttca aaaaccttgc cacgccgtcc tcttcatttg tggccgtagt 1172521 tcggttggca atctgcttga ccgcgtcaat tccatttccc attgcaacgc cgcagcctgc 1172581 aaattcaagc atttccaaat cgttatcctc atctccaaaa gcaatgatcc gctccctcgg 1172641 cacgccgtaa taatcgctga ttttctgcag gccgaccgct ttattcatgc cgcttttgat 1172701 aatttcaatg acatgccaag gagcggccca tcttctatgg tcgatcacct cggcatgcac 1172761 atccgataaa tatgagcgta ttgccggcac atcctcttcc tttgcatgta tgagtacgga 1172821 cgtcacatct tcaccgagat tttcccgcaa gtctccgacc gttacatttg ttgtgttcat 1172881 gttaaaggca tctatcaggt gctcatcatg gtaatgaaag tatacgtcgt caatcacttc 1172941 agcaagcacg ttatgtacgt tgtagctctc gctgatatcc acgagctgtt tgacaacatc 1173001 aagcggcagt gacgtatgat accgtcccca gctgtcgtct tgcggatgat ggacaaatgc 1173061 tccgttaaaa ttgacaattg gcgttgtcag ctccatctgc tggtagtaca tggaacttga 1173121 acgatacgga cggcctgttg agatgcagac ataatgcccg tcatctttta ggcgctgtat 1173181 cgtatgaagg gtgttttcag atatggtttt atcatccttt aataatgttc catctaaatc 1173241 taatgcgatt aaatagggtt ttgtctccat gaaaagctcc tttaacctta gattttgctt 1173301 gttttgcctt acttacagtg tagcttttta ccatctttat tgtctacatg ttacacttat 1173361 gattatggtt atcctaagga ggggcacatt gtgatacaaa ttgagaatca aaccgtttcc 1173421 ggtattccgt ttttacatat tgtaaaggaa gagaacaggc accgcgctgt tcctctcgtg 1173481 atctttatac atggttttac aagcgcgaag gaacacaacc ttcatattgc ttatctgctt 1173541 gcggagaagg gttttagagc cgttctgccg gaggctttgc accatgggga acggggagaa 1173601 gaaatggctg ttgaagagct ggcggggcat ttttgggata tcgtcctcaa cgagattgaa 1173661 gagatcggcg tacttaaaaa ccattttgaa aaagagggcc tgatagacgg cggccgcatc 1173721 ggtctcgcag gcacgtcaat gggcggcatc acaacgcttg gcgctttgac tgcatatgat 1173781 tggataaaag ccggcgtcag cctgatggga agcccgaatt acgtggagct gtttcagcag 1173841 cagattgacc atattcaatc tcagggcatt gaaatcgatg tgccggaaga gaaggtacag 1173901 cagctgatga aacgtctcga gttgcgggat ctcagccttc agccggagaa actgcaacag 1173961 cgcccgcttt tattttggca cggcgcaaaa gataaagttg tgccttacgc gccgacccgg 1174021 aaattttatg acacgattaa atcccattac agcgagcagc cggaacgcct gcaatttatc 1174081 ggagatgaaa acgctgacca taaagtcccg cgggcagctg tgttaaaaac gattgaatgg 1174141 tttgaaacgt acttataaag cactaagtta ttaacaagag ctgaatttac gttatactgt 1174201 agaaaaaagg agtgagggaa cgtggaagaa gcattaaaag aaaacatcat gggcgccctg 1174261 gaacaggttg tcgatcctga gcttggcgtt gatatcgtga acctcggctt ggtatatgac 1174321 gttgatatgg atgaagatgg cttgacgcac atcaccatga cgctaacatc aatgggatgc 1174381 cctttagcgc cgattatcgt ggatgaggtg aaaaaagcat tagcggacct tcctgaagtg 1174441 aaagacacag aggttcacat tgtatggaat ccgccttgga ctagggataa aatgtccaga 1174501 tacgcaaaaa ttgcgcttgg cattcaataa aacaaaaaag gacagcctga catgtgaggc 1174561 tgtccttttt tacagctgaa aggagtgaaa ggaaatgatg tacctgctgg cagttttatg 1174621 cccgccgctt gctgttttgt tttcgggaaa accgtttcag gccttgctga atctcatatt 1174681 gacctgtatc ttttggctgc cgggcgcgat tcacgcctgc tttatcgtcg ccgaccgccg 1174741 tgccgaaaaa cgggcaagaa gataatttgg aaaaatgagg acgcagtcat ggtataatgg 1174801 tcataaaaac agcagggaga gcactatgaa aaagaaattg cttgcattcg cgctttgtac 1174861 tggcgcgtat gcggccctgt ttgcgtactc tgtgaactca gagcaaaaaa cagccacaag 1174921 cgagatgacg gatgtcagcc gcctgatgcc tgtaaaaata aagcagacag tgaaagggca 1174981 ggaagaggaa atgctcattg acacagtcaa agaggcaaat cgaaaaaaca taaaaatttc 1175041 aatcgccggg gcccagcact ccatgggcgg ccatacatat tatgaggacg gcatcgttct 1175101 cgacatgacg ggctacaaca aaatcctgtc actcgatcaa gagaagaaaa ccatcagggt 1175161 gcaaagcggt gcaacgtgga atgatatcca gaaatacgtg aatccatacg gactcgcggt 1175221 aaaagtcatg cagtcacaaa acatttttac aatcggcgga tctctcagcg caaatgcaca 1175281 cggacgtgat attcgctacg gctcgctaat tgatacagtc aaatcattcc ggcttttaaa 1175341 agctgacggg atgattatca ctgtcactcc aaaagatgat ttgtttacgg cggtcatcgg 1175401 agggtacggc ctttttggcg tgattcttga tgtaacgctt gagctgacag atgatgagct 1175461 gtatgtcatg aagacagaaa aaatgaatta cagcacatac tcagactatt tttcaaagca 1175521 tgtaaaagga aatccagatg tccgaatgca tctggcgcga atttcaacag cgaaaaaagg 1175581 atttctgaaa gacatgtatg tcacgaatta cgtattggct aatcatcagg atcagctgtc 1175641 ctcatacagc gaacttaaag aagacgagta tacgggagcc acaaagtttg cactcggctt 1175701 gtcaagacgg tatgaatggg ggaggaattg gctgtgggac acacagcaat cctatttcct 1175761 gagccagaac ggcacagaga tttcacgcaa taacgtcatg cggtccgaat caaagtttct 1175821 tgagtatgaa aacaatgaca acacagatgt tttgcaagaa tactttgtgc ccgtgaagga 1175881 gtatgggtcc tatattgatg acctgagaca aacgctgtcg gacgaagatc tgaacctgct 1175941 gaacattacg atccgctacg tgcagaaaaa tgaaaaggcc gacctttcct atgcgaagga 1176001 cgatatgttt tcgctcgtac tattaataaa cgagggcttt tcaaaagaag accaggcaga 1176061 taccgcccga atcatcaggc gcatgacaga cgttgccatc aagcacggcg gcagctatta 1176121 tctgccttat atgacctacc agacaaaagc gcaaatgaga caggcatatc cgaaaagtga 1176181 agcgtttttt cagaaaaaac gaacctatga cccggatgag cgctttatga attactttta 1176241 tcagaggtat aaataatggg gaaaaacaaa ttaaaatggc tgacattatc acaaagcagc 1176301 gtgtttttcg caagcagctt aatctttccg ttttatattc tgtttgtgaa aaatatcggc 1176361 tcaagctaca cacagttcgg tttttcctac ggattgttcg ggttgagcgg agcgcttatt 1176421 tacccgctcc tcggacggct gtctgaaagg tttgacagcc gttattttct gcttctgaac 1176481 tcgtggggga tggctgttct gcttttatat gtcccgcata tcggaagcgt cgttcaagtg 1176541 tatatcgtcc aagtgctgtt agggctcttt ggagcgatgc aaaagcatgg agaaaaagtg 1176601 ctgatcgcta attttacaga cagtggagag cgtggaaaga agatcgggaa ttaccatttt 1176661 tggacagctg tcttttcagc agcagccatt atgctcgggg gctttctcgc tgactttttc 1176721 acagtgcaaa tgatttttta tgcaagctct attctatatt ttttgagtgg attgatgatg 1176781 atgaaaacag gctgacgcgg tcagcctgtt tttttatgcg gctgaaatgc ggcaccgcat 1176841 caacgttttt gtgctggagt cgtgctgatt ttttttgagc ggaattccca ttgaacagaa 1176901 aatttataaa tgaataaaaa tattaaatat acgattgaat taatttttat tcatgttata 1176961 atgttaaata atttcacaaa gaccaagagg gtgaacttgt tttgaaaata ggaattgtag 1177021 gtgctacagg atatggaggc accgaacttg tcaggattct ttcgcatcat cctcatgcag 1177081 aggaatgcat actttattca tccagcggag aagggaatgt ctatagcgag ggttatcctc 1177141 atcttaccgg cttagcggat cagcagctga agccgattga tatgaatacg atcaaacacg 1177201 aaatagatat catgtttctc gctgcgccgc ccggagtatc aagtgaattg actccaaagc 1177261 tggcagacgc gggaattacg gttattgatc tgtcaggtga tctgaggata aaagaaccgg 1177321 ctgaatatga aaaatggtat aaacggacag cggcaccgaa ggcggtgatt caagaggcgg 1177381 tatacggtct ggcagaactg aatcaactgc aaattcaaca ggcgaaactc attgccaatc 1177441 caggctgttt tccaacagct gttttgcttg gcctcgcgcc attggctcaa aagaaactgc 1177501 tcgatgaatc tttcgttatc gttgacgcga agaccggtgt ttccggagcg ggaagaaaag 1177561 catccatggg aactcatttt tctgagctga acgacaattt taaaatttat aaagtcaatg 1177621 aacatcagca cacgccggaa attgagcagg cgctgaatga atggcagcca ggtctcgggc 1177681 ccattacatt ttcggctcac ttggttccga tgacaagggg catcatggcg acgatgtata 1177741 ccagattaac ctgtgaccta accgcagatg acctgcatga tttatattcg gaattttacc 1177801 aagattcata ttttgtgaga gtgaggccaa aaggtcagta cccgcaaacg aaagaagtgt 1177861 acggcagcaa tttctgtgat atcgccgtga ccctcgatga gagaacgaac agagtcacga 1177921 tcgtctcggt aatcgataat ttaatgaagg gtgccgccgg tcaggcagtg caaaacttta 1177981 atttgatgaa tggctggaat gaagaaactg gactcaccat cacgccaatt tatccataga 1178041 acgggagaga atcgaaccat gattcagtta agtgaagatc aaattgtaaa agtaacaggt 1178101 gatgtatcct cgccaaaagg gtttcaggca aagggtgtgc attgcggact gcgctactcg 1178161 aaaaaagacc tcggcgtcat tatcagcgag acaccggccg tgagtgcagc agtttatacc 1178221 caaagccact ttcaggctgc tccgatcaaa gtgacacaag acagcttaaa gcacggaccg 1178281 acactgaaag ccgtcatcgt caacagcgcc attgccaacg cctgcacggg agaacagggc 1178341 ttaaaggacg catacacaat gcgggagagc tttgcttcac agcttggcat tgagccggag 1178401 cttgtcgctg tttcatcaac gggtgtcatc ggcgagcatt tagacatgga aaaaatccac 1178461 gcggggatcg aactgctgaa agaaacacct gcgggatcag gcgattttga ggaagcgatt 1178521 ttaacaactg atacggtgat caagcagacg tgctatgaac tggcaatcgg cggcaaaaca 1178581 gtcacgatcg gcggagcggc caaaggctct gggatgatac acccgaacat ggccacgatg 1178641 ctgggatttg tgacaactga cgcggcaatc gaagaaaaag cgctgcaaaa ggcgcttcgg 1178701 gaaatcactg acgtttcatt taaccaaatc acagttgacg gagaaacatc cacgaacgac 1178761 atggtattag ttatggcgaa tggctgcgcc gaaaacgagt gcctgacaga agaccatcca 1178821 gactggccgg tctttaaaaa agcgctcttg ctcacttgtg aggatctagc taaagagatt 1178881 gccagagacg gagaaggcgc gacaaaacta attgaagccc aagtacaggg agcgaaaaac 1178941 aatcttgatg caaacgtcat tgccaaaaag attgtcggct caaatcttgt aaaaacggca 1179001 gtatacggaa cagatgccaa ctgggggcgg atcatcggag ccatcggaca ctccgcagca 1179061 caggtgacgg cagaagaagt agaggtttat cttggcggcc aatgcctgtt taagaataac 1179121 gaacctcagc cattctctga atctatcgcc aaggaatacc ttgaaggaga tgaaatcacc 1179181 attgtcatca agatggctga aggggacgga aacgggagag cgtggggctg tgacctgacc 1179241 tatgactata tcaaaattaa cgcgagctat cgcacgtaat aaaggggagc gaaatgaaga 1179301 aaacaatcgt ttttaaatgc gggggaagcg tcatccgtga gctgtcggag gaattttatc 1179361 aaaatctgaa agagctgagg gcgtcaggct ggaagctggc aatcgtacat ggcgggggac 1179421 cggaaatcac aaatatgctg aaacggttaa atatcaagac agagttttcg ggcggacaga 1179481 ggaaaacaac gaagccggtg ctggaagtgg cggaaatggt tttatccggt tctgtcaata 1179541 aatttttcgt tgctgagctt gccaaacacg gactgcgagc cgcgggcatt tctggtaagg 1179601 atggcggtct tttggaggct gattatctag atccggaaac atacggagaa gtgggagaaa 1179661 tcaaaaaagt cgatgcgtcc atggtgaacg cgctgatgga aaatggcatc atccccgtta 1179721 ttgcgccgct gtctatgaca agcgactgca aaacgctgaa tgtaaatgct gatctggctg 1179781 cttcagcagt cgccggagcg cttgaagccg ataagctgat gttcgtcacg gatgtcgatg 1179841 gaatcatgaa ggaaaagcag cgtctggacg tcctgacccc taaggagatt cagatgctga 1179901 tcaagcagga agtgatcaca ggagggatga tcccgaaggt caattcagcc ttgtcagctt 1179961 tatcagatca ggtgtctgaa gtcatgatcg taaacggtaa aggatcattc ttcgcagaac 1180021 aaacctttca agggacaaaa attgtcaaag caaaggaggc tgtttcatga gcagcttgtt 1180081 tcaaacctac ggccgttggg atattgacat caaaaaagca aagggaacgt acgttgagga 1180141 tcaaaacggc aaaacgtacc ttgatttcat tcaggggatt gcggtatcaa atctaggaca 1180201 ctgccatgaa gcggtgacag aggcagtcaa aaaacagctt gacagcgtat ggcacgtatc 1180261 caacctgttt caaaacagtc tccaagagca agcggcgcag aagctggcag cgcatagtgc 1180321 gggagatctt gtctttttct gcaacagcgg cgcggaggcg aatgaaggtg cgataaagct 1180381 tgccagaaaa gcaactggaa aaacaaaaat catcactttt cttcagtcgt tccatggccg 1180441 cacgtatgca gggatggctg cgaccggaca ggataaaatc aaaacaggct tcggcccgat 1180501 gcttggaggc tttcactacc tgccatacaa tgatccttct gcttttaaag ctcttgggga 1180561 ggaaggcgat attgccgcgg tgatgcttga aacagtgcag ggagaaggag gagtcaatcc 1180621 ggcgagtgct gaatttttat cagccgtaca gtcgttttgc aaggaaaagc aagcccttct 1180681 cattattgat gaaatccaga ccggcatcgg acggacggga aaaggcttcg catatgagca 1180741 cttcggactc tcaccggata tcatcacagt cgccaaagga ttgggaaacg gctttccggt 1180801 cggcgctgtc atcggaaaga aacagcttgg agaagcgttt acccctggtt ctcacggaac 1180861 gactttcgga ggaaacatgc tggcgatggc tgctgtgaat gccacattgc aaattgtatt 1180921 ccagcctgac tttttgcaag aggctgctga caaaggggcg tttttaaaag aacagcttga 1180981 ggcagagcta aagagccctt ttgttaaaca aatccgaggt aaaggattaa tgcttggaat 1181041 tgagtgtgat ggcccggttg ctgacattat tgctgaattg cagacattag gcttgcttgt 1181101 attgccggcc ggcccgaacg tgattcggct gctgccgccg ctcaccgtga ctaaggatga 1181161 aatagcagaa gccgtcagca agctgaaaca ggcaatcgct catcattccg ctgtaaacca 1181221 gtgatttttt ttcgatataa aggcataaaa attcattttt ataattaatt attcatcaag 1181281 aggtgggctg ttagatggaa ggttatttag tgttagaaga tgggacatcg ttcagcggcg 1181341 agctggacgg tcatgaaaac tgcacgggag aagctgtttt tttcacagga atgacaggct 1181401 accaggaagt gctgacagat ccatcatata agggacagat tattgtattt acctacccgc 1181461 tgattggcaa ctacggcata aatgaaaagg attttgaaag caagaaaccg caagtaaaag 1181521 ccgcggttgt ctatgaggcg tgtgatcact tttctcatta tgaagcggta tacagcctca 1181581 aggagtatct acagaaatgg aatattccgc tgttaaccca tgttgatacg agggctgtcg 1181641 tgaagaaaat ccgggcaaac gggacgatgg gtgcgacagt cacagcctct aaagaaggag 1181701 ctgagattgc ccttcaacca gagaatgtgg cagagcaggc ttccgcccag gaaatcagca 1181761 cattcggcga cgggaataaa catatcgctc tcattgattt tggctataaa aagtcaatcg 1181821 catcatcact tgtcaaacga ggctgcaagg ttaccgtggt gccataccag caaatggagg 1181881 ccgtatacaa catcaaaccc gatggaattg tgctatcgaa cggacctgga gatccgaaag 1181941 ccattcagcc atatttagga aagatcaaaa gcatcatcag ccgctttccg actctaggca 1182001 tttgtctcgg acatcagctg atcgcgctcg cgtttggagg gaatactttt aagctgccat 1182061 tcgggcacag gggagctaat catccggtca tcgaccgtaa gacgaaacgg gtctttatga 1182121 caagccaaaa ccacagctat gtggttgatg aacagtcgat taatgaagaa gagctcacca 1182181 tcaggtttca tcatgtcaat gatacgtcag ttgaagggct tgcccataaa aaactgcctg 1182241 tcatgagtgt tcaattccac ccggaagccc atcccggacc tgcggaaagc gaatggattt 1182301 ttgatgatta tctaaagaat gtgataccag caaggagaga aatcgcgcat gcctaaagac 1182361 accagtattt caagcatatt agtaattggc tcaggcccga tcatcatcgg gcaggcggca 1182421 gaatttgatt attcaggcac tcaagggtgc atcgcgctga aggaggaggg ctaccgggta 1182481 attctcgtca acagcaatcc ggcgacaatt atgactgatg aagccttcgc tgatgaaatt 1182541 tattttgagc ctctgacagc agaaagcctg acagccatca ttaagaaaga acggcctgat 1182601 gggcttcttg ccaatttagg cggtcagacc gcgttgaatt tagcggtgga gcttgaagaa 1182661 acgggtgttt taaaagagca cggcgtcaaa ctcctcggca catccgttga aacgatacaa 1182721 aaaggagagg accgggaaaa attccgttcg ttaatgaatg aattaaaaca gcctgtgccg 1182781 gagagtgaaa ttgttgataa cgaggccgat gccctccatt ttgcggaatc catcggtttt 1182841 cctgttatta tcagaccagc ttacacatta ggcggaaagg gcggaggaat cgcccctgat 1182901 aaagaagcct ttacagctat gattaagcag gcgctattag caagcccgat caatcaatgc 1182961 cttgtcgaaa aaagcattgc cggctttaaa gaaattgaat atgaagtcat gcgtgacagc 1183021 aataacacat gcattaccgt ctgcaatatg gaaaatatcg atccggtcgg cgtgcataca 1183081 ggtgactcta tcgttgtggc gccgtcacaa acattgacag acgaagacta tcaaatgctg 1183141 cggacagcaa gtctgacgat catctcagca cttgatgttg taggcggctg caacattcaa 1183201 ttcgcgcttg atccattcag caagcaatat tacgtcattg aagtgaatcc gcgtgtaagc 1183261 cggtcatcgg ctctcgcatc taaagcgacc ggttatccga ttgcgaagat ggccgcgaaa 1183321 ctggcagtcg gatacactct tgacgagctg aaaaatccgc tcacaggctc gacttacgca 1183381 agctttgaac cggcactgga ttatgtgatc gtcaaatttc cgcgctggcc gtttgataaa 1183441 ttcaaaaacg cagaccgcaa gcttggcaca aaaatgaaag ccaccggtga agtgatggcg 1183501 attgaacgga atttagaagc ggcgatacaa aaggcagccg cgtcgcttga attaaaaaat 1183561 atcgggacac accttccaga gctcagcggg ttgtcaattg atacgctatg ggatttggca 1183621 atcactccgg atgaccgcag atttttcgtt gtcatggagc tgttgagccg cagcgtctcg 1183681 attgatgaca tccatgaaaa aacaaaaatt gatccgtttt tccttcatac ctttgacaac 1183741 atcatcaaat tggaaaaccg cctgatggaa gcagggagcg atctctcttt tgaattattg 1183801 aagaaagcaa aggaaaaggg attctcagac gcaacgattg cctcgctgat cagcaaaaca 1183861 gaagaagagg tgcgcgcgct tcgcaaggag atgggcatta cgccttcctt taaaatcgta 1183921 gatacatgcg cggcagagtt tgatgcgaaa acaaactatt tttactccac atatttcgga 1183981 gagaccgatg gagacatcag ccgcaaagag aaaaaacgcg cgctcattat cggatcaggc 1184041 ccgattcgga tcggccaagg cgttgaattt gattacagtg ctgttcacgg tgtgctgaca 1184101 ctgcaagagc ttgggttcga aaccatcatg attaacaata acccggaaac tgtcagcacc 1184161 gattatgaaa ttgcggaccg cctgtatttt gaaccgatga caacggagca tattgtaaac 1184221 gtggcggagc aggaaaatat tgattttgca attgtgcaat ttggcggtca aactgcaatc 1184281 aatgctgctg aagcgctcga aaaagccggc attactcttc ttggcacatc atttcaaacg 1184341 ctcgacgtgt tagaggatcg ggatcaattt tatcagcttc ttgacgagct gggattgaag 1184401 cacgcaaaag gagaaattgc ttatacaaaa gaagaagccg cttcaaaagc gagtgagatc 1184461 ggctatccgg tgttaatccg cccatcttac gttatcggcg gaatgggcat gatcattgtt 1184521 gactcgcaag cccagctttc tcagctgctg aatgatgagg acagcatgcc atacccgatt 1184581 ttaattgatc agtatgtgtc tggaaaggaa gtcgaaattg atttgatttc cgacggcgag 1184641 gaagtcttta tcccgacata taccgagcat attgaacggg caggtgtcca ttcaggggac 1184701 agttttgcca ttcttcccgg accgtccatc acgagcgggc tgcagcaggg catgaaagat 1184761 gcggcacaaa aaattgcccg aaaactttca tttaaaggca tcatgaacat tcaatttgtg 1184821 atcgacaatg gaaacatact cgttcttgaa gtgaatccga gagcgagccg cacggttcct 1184881 gtcgtcagca aagtaatggg cgttccgatg attccgctcg ccacacgtct gctggcggga 1184941 gcgtccttaa aagatctaaa tccggcagtt caaaatcatc atggagttgc cgtgaagttc 1185001 cctgtttttt cttctcatgc gatccaggat gtggatgtca agcttggacc ggaaatgaaa 1185061 tcaacgggag aaggcatgtg tgtcgcatat gattctaaca gcgccttgaa aaaaatctat 1185121 acaagagtct ggagtcaaaa aggaagcatt tatttgcaaa acgttccgga agatgtgaag 1185181 gagttagcag aaaacgcagg ttttacaata catgaaggaa catttgcctc atggatggaa 1185241 caggaaggaa actcgctcca cattaatctg agcggttctg aagaagcacg caaagaacgt 1185301 ttggaagcca tgacgcacgg catccccgtc tttacagaag aagaaactgt gcgggcgttt 1185361 ttacaaagcg gttcaggcca tccgcagcct gtatctctca aagacctcta taaaaaggaa 1185421 gtggcatcat gcacacagtg acgcaaacca gtttatacgg aaaagattta ttaacgttaa 1185481 aggaccttag tgaagaagat ataaacgcct tgctcgcaga agccggtgag ctgaaacaaa 1185541 acaaaattca gcctatattc catggcaaaa ccttggcgat gatttttgaa aaatcatcaa 1185601 cgcggacccg tgtttcattt gaagcgggca tggcgcagct gggcgggagc gccctctttc 1185661 taagccagaa agatctgcag ctggggcgcg gtgagactgt cgctgatacg gcaaaagtgc 1185721 tgtcaggcta tgtggatgcc atcatgatcc ggacctttga acatgaaaag gtggaggaac 1185781 ttgccaaaga agctgacatt ccggtgatca atggacttac cgataaatac cacccatgcc 1185841 aggcgctggc ggatctcttg acgattaagg agataaaagg gaagcttaaa ggcgtaaaag 1185901 tcgcgtacat cggtgacgga aataacgtgg cgcactcctt gatgatcggc tgcgcgaaaa 1185961 tgggctgtga tatctcgatc gcttcaccaa agggatatga agtgttagat gaagcagctg 1186021 aagcggcaaa gacatatgca cttcaatccg gctcttctgt cacgctgaca gatgatccga 1186081 ttgaagctgt aaaagacgcg gacgtgattt attctgatgt gtttacaagc atggggcagg 1186141 aagcggaaga gcaagaacgt cttgctgtct ttgcgcctta tcaggtgaat gcggcgctgg 1186201 tcagccatgc caagcctgac tatacatttt tacattgtct ccctgcgcat cgcgaggaag 1186261 aagtgactgc ggagattatt gacgggccga actctgcagt gttccagcag gcggaaaacc 1186321 gtcttcatgt gcaaaaagca ctgctgaagg ccattttata taaaggggaa tcatcaaaaa 1186381 actgctgagc caaactcagc agtttttttg atggcaacat attcacagcc gcttaggcgc 1186441 atactacagc aaaaaggaaa aggaggaaaa acagtgggac agcagcacca attccggccc 1186501 ggacagaaag cgcctaataa cggtgtctac gtagaaatcg gcgagacagg gagcatggtt 1186561 aaaaaccctc aaaaggtcca tctgtcagca ggggaaatgt tccccgaaac atcaaaccac 1186621 aaccggctgt ggacctacaa aagaaagccg tgaccactaa aaaacccaaa acaataaatg 1186681 ttttgggttt ttggcttttt aatgctggct tgcatttttg ttcataggca tgatttctgc 1186741 taaaaccatg attaagacat acagtacaac agcaatgaca gatgatgttt tgaaattata 1186801 cgtaacgctg ttcatgcttg caaccaagta gcatgccata tgtgataaaa ggaacgtcca 1186861 aataaaggca ataatatatc gcacgtttcc acctcgtcct tctcattcta ttctaaaagt 1186921 tatcatacca tacaaaaagc gaagggggaa tccaatttta gcagaaagtg aggtgacaaa 1186981 agagtctgat tcgtcacact ttaatggtaa aatataaaac gtcaatcagt ataatagcca 1187041 aaaatgtaaa aggctaggac tttaccttat tcgtttcttt tctatttaca taagatagcg 1187101 tgagatgaag tgtgaaagga ggcgggcaag cgatgggaat aacggaaaga tactttcaac 1187161 tgggaacgga gcataatgtc attcatctgc cctatcgccc gaacggcttc ggcatcttta 1187221 tcttggggga cagaacccac tttgtcggac atgattcaag cttttggcag cagcattatg 1187281 gcagaaatca gcttctgagc atgttgatga atgaaggata cactcttttt aacagcaatc 1187341 tgttcggaag gcattggggg gcggaaaaag cagtcaccta tgccaaacag ctgatacatt 1187401 ctgtgctgaa gcaggaaatc ctcaatccga agattcatat tttagcagaa ggcatgggtg 1187461 ctctcgtggc cgatgaactg cttcgttttt ccccggatca tatccgctca gccgcaatgt 1187521 tgaatccttg tctcgatctt caggcacatt atgaatcgga aaaagaaaat aaatttttct 1187581 ataagcaatt tttgaaagaa gtatcgaaaa gctacggaat ttctgaaaaa gaagcggaag 1187641 cgattcgtta taaaacaatt caaagctacc cgagcggcgt accggttcat atatggcagc 1187701 gtatgaccgg agctccatat ccctacagcg tacatgcgga agttttcaag gaaaaacagc 1187761 aaaagcaagg ctcaccggtc gacatgacat ttcatttatt tgagcatcca agcagaattt 1187821 atgcatcaat ttgcaaattc tttcatagtc atgaaaaaga attatagaga atataatgac 1187881 aacagccttc tcttttgcgg aggctgtttt gttttgggaa atgaaaaacc ggaagggcgg 1187941 cagatgcaat ggaatcaacg ctgattgtag gtgcggacga atttttcggc ctttcattat 1188001 gtgagcgaat gatggatgaa ggcatacatg ttgacgttgt tctggcggaa acagaagata 1188061 aaatgagaca aatgtactta gaagaaagac tcatgtggct tgggagaaat gaactctttc 1188121 gccagcttga acacattgga gaccaaaatt atgatacaat ttgtatccag ttcggaagtt 1188181 ttttgccttt agaccaatat gattctcctt atattttagt atatgaagaa gaccgaaaag 1188241 aatgggataa acgtgaaaaa acaggctcgg aaaaaaccgt gatcctgccg aaaatgtacg 1188301 ggccatggaa agaagaaaca gaggaagacg gctattacac aaacgacgtg gctgacgagt 1188361 tgctgagatt cctgttagaa ccaagccgtc atagcaaaga tcagcttttt gaattgcaag 1188421 tcacagagaa aacctcaaaa gaagaagcaa aaacaaaaat tatcgagtgg aaaagacaat 1188481 tttcatcaat tttcgacaaa tattaagaaa aaccttccat gtttcgagtt ttctagatac 1188541 aataaacgta taaaaataat acatgttata gcttgtcaaa aggagttgaa catgacttga 1188601 tcacaaggct tgtcatgatc ttttctgtcc tccttttatt gagtggatgt ggacaaactc 1188661 cgttcaaagg aaaaattgag aaggtcggca tgctctttcc tgatacgatt aatgacctcg 1188721 tatggggcac aaaagggtat aaaggattac tgaatataca atccaaatac aatgtggacg 1188781 tctattataa agaaggcgtt aaaacagaag aagatatcat aaatgcgatt gaggattttc 1188841 ataagagggg cgtcaatctg ctctacggcc atgggagtga atatgctgag gtgtttaact 1188901 tggtcggcga agattatcca gatatggaat tcgtcatttc caatgcgaaa gcgaaagctg 1188961 ataatgtaac aagtgtccat tttagcgggg aagcaatggg cttttttgga ggaatgactg 1189021 ctgcccatat gtcgaaaacg aatcaggtcg gtgtaattgc ttcctttacg tggcagcctg 1189081 aggttgacgg ttttatcaaa ggggccaagt atgaaaatcc ggatatagag gtaaatacga 1189141 aatatacgga tcattgggat gatgatacaa cagcagtaaa gctttatcag aaaatgaaga 1189201 acgaaggcgc ggatgttgtg tatcccgccg gagacgggta taatgttcct gttattcagc 1189261 aaatcaaaaa agacggtctt tatgccatag gctacgtcac agatcaatcg gatctgggcg 1189321 agaataccgt attaaccagc acggtgcaaa atgtggacaa ggcctatgaa atcattgctg 1189381 aacaatttaa taaaggcacc cttgagggcg gcgatcatta ctacgacctg aacacgggag 1189441 tcgttgagat gggaacattc agcccgctcg tcgatcaaga ctttcagcaa agaatcgcca 1189501 agctgatcaa aacatacaac aaaacaggcg agctgccaaa aaacgagtaa tggagtgacg 1189561 tcacatgcag cacgaaaaat cacttgaatt cttgcaaatt gccatgaaat atctccctga 1189621 agcgaaagaa cagcttgaga aatcaggcat tgagctctca atggaggcca tccagccgtt 1189681 tatgaatcta tttacaacgg taatggcgga agcttatgag cttggcaagt ctgacgctaa 1189741 atctgaaaca gaataagaag aagccacttt tttgaaagtg gcttttcaca tgattttctt 1189801 tttaatagcg gagagcatgg gcgcaagctc ctttaaagcg ggcttgattt gatcaagaga 1189861 gttcataatt gaaccgattt ggtccataat atgcatgtaa ttaatcgtct cttcgtcgtt 1189921 tgtctgagaa acctgagaaa cttcctcttg ctgttcctcc tccttctctt ctgttggttt 1189981 tgctgcatcg ccgaacatca ttcttgaaaa cacatccaac tgcatacgcc tcctttccat 1190041 ataccatact ctatgagtaa gatgaactga tagtttagac gaatatattg ccatgtgaaa 1190101 aaaaatagga tagaattagt acctgatact aataattgat cacaacctga ttgatcttct 1190161 aaatttaaga tataaaggag tcttccctaa tgaaagctgg aatacttggt gttggacgtt 1190221 acattcctga gaaggtttta acaaatcatg atcttgaaaa aatggttgaa acttctgacg 1190281 agtggattcg tacaagaaca ggaatagaag aaagaagaat cgcagcagat gatgtgtttt 1190341 catcacatat ggctgttgca gcagcgaaaa atgcgctgga acaagctgaa gtggctgctg 1190401 aggatctgga tatgatcttg gttgcaactg ttacacctga tcagtcattc cctacggtct 1190461 cttgtatgat tcaagaacaa ctcggcgcga agaaagcgtg tgctatggat atcagcgcgg 1190521 cttgtgcggg cttcatgtac ggggttgtaa ccggtaaaca atttattgaa tccggaacct 1190581 acaagcatgt tctagttgtt ggtgtagaga agctctcaag cattaccgac tgggaagacc 1190641 gcaatacagc cgttctgttt ggagacggag caggcgctgc ggtagtcggg ccagtcagtg 1190701 atgacagagg aatcctttca tttgaactag gagccgacgg cacaggcggt cagcacttgt 1190761 atctgaatga aaaacgacat acaatcatga atggacgaga agttttcaaa tttgcagtcc 1190821 gccaaatggg agaatcatgc gtaaatgtca ttgaaaaagc cggactttca aaagaggatg 1190881 tcgacttttt gattccgcat caggcgaaca tccgtatcat ggaagctgct cgcgagcgtt 1190941 tagagcttcc tgtcgaaaag atgtctaaaa ctgttcataa atatggaaat acttctgccg 1191001 catccattcc gatctctctt gtagaagaat tggaagccgg taaaatcaaa gacggcgatg 1191061 tggtcgttat ggtagggttc ggcggaggac taacatgggg cgccattgca atccgctggg 1191121 gccgataaaa aaaggtgagg tgcacacaag atgactaaaa aaagagtagt tgttacagga 1191181 cttggagcat tatctccact tggcaacgac gtcgatacaa gttggaataa cgcaatcaac 1191241 ggtgtgtccg gaatcggtcc gatcactcgt gttgacgctg aagaatatcc ggcaaaagtt 1191301 gccgctgaat taaaagattt taatgttgaa gattatatgg ataaaaaaga agccagaaaa 1191361 atggaccgct ttacacaata tgcggttgtg gctgcgaaaa tggcggttga agatgcagat 1191421 cttaacatta ccgatgagat cgcgccgaga gtcggtgttt gggtaggctc cggtatcgga 1191481 ggacttgaaa cactagagtc tcaatttgaa atcttcttaa caaaaggccc aagacgggta 1191541 agcccgtttt tcgtgccaat gatgattcct gacatggcga caggccagat ttctattgca 1191601 ttaggagcaa aaggggtgaa ctcttgtacg gttacagcat gtgctacagg aacgaactcc 1191661 atcggtgacg cgtttaaggt tattcagcgc ggtgatgcag acgtgatggt cacaggcgga 1191721 acagaagcgc cgctgacaag aatgtcattc gccggcttta gtgccaacaa agcgctgtct 1191781 actaatccag atccgaaaac agcgagccgc ccgtttgata aaaaccgtga tggctttgtc 1191841 atgggggaag gtgcagggat tatcgttctt gaagaacttg agcatgccct ggcccgcggc 1191901 gctaaaattt acggagaaat tgtcggctac ggctcaaccg gagacgctta tcatatcaca 1191961 gcgccggccc aagacggtga aggcggagcg agagcgatgc aagaagccat taaagatgca 1192021 ggcattgcac ctgaagaaat tgattacatc aatgctcacg ggacaagcac gtattacaac 1192081 gacaaatacg aaacaatggc gattaagacc gtttttggcg agcatgcgca taaacttgcg 1192141 gtaagctcta caaaatcgat gacaggccac ctcttaggag cagccggcgg tattgaagcc 1192201 attttctcta tcctggccat taaagaaggc gtgattccgc cgacaatcaa tattcaaaca 1192261 cctgacgaag aatgtgattt ggattatgtg cctgatgaag cccgcagaca ggaacttaat 1192321 tatgttctca gcaactcatt aggattcggc ggacacaacg caacattaat ctttaaaaaa 1192381 tatcaatcat aatcaagcca aaccggctgc ccttaaaggg tagccggttt tttttgtgtg 1192441 cataggatta aaagaggagg cgatcacatg agtgtagaac aaacatatag ctggctcagg 1192501 aaggccggtt caatagatga tttggcgcat tacattatcc cgcttttttc aggtgcggag 1192561 aaaaagaact ggaagggcat tctggggcat cttcagcatc atgggatgtt taaaaacata 1192621 aaagagggta ttcagacggt ttccaagctg aaggaaaaag gtttttacgg acatatccaa 1192681 aaggaagaac agtacctcaa aaacaaatgg caaggtcctg atgtaccaat tgttacgctg 1192741 ccggttgatg aacgaaacag gagaatccgt ttagaattcg gatcaaaatc aggactcgcc 1192801 tttcaagaca aaatgttcct ttttctttcg tcagatttag attttgggtc ggtatctgcc 1192861 cttatgacgc atgagtatca tcacgtttgc cggttaggtc atctgacaaa agaggaaaag 1192921 gatgtcacat tacttgatac aatcatcatg gaagggctgg cggaatatgc tgtttatgag 1192981 aggttcggcc gaagtcaaac ggctgaatgg acgacttggt atacaccgga acagcttcag 1193041 gctttatatg aaaaaaagat tgcgccccat cgggatatca aacgggataa tcgattattt 1193101 ccccagctgt tattcggcaa aggatatcag ccaaaaatgc ttggatacgc agttggattc 1193161 aatattgtaa aaaaatattt aaccgccagc aaggcaagca ccgcagacgg gctgtccatt 1193221 cctgctgaga cctttttgga tgcaatgctt taaaaggata aaataatgga atttcattaa 1193281 taatattaca tttatcctaa aaaattcttg attttgcaaa atgattgtaa taatatacaa 1193341 ctataaaatt tttcgataat tcaatattat ttattatttc tgaataaagg gattgctttc 1193401 tcttgaaaac gtttgacaac aagagggggg aaaggggagc tagcatgagc acacttttag 1193461 aagtgaataa tttaaagact tattttttca ggaaaaagga gccgatccct gcggttgacg 1193521 gagtcgattt tcacatcagc aaaggcgaaa ccgtcgcgct tgtaggtgaa tcgggctccg 1193581 gaaaaagcat tacttcttta tcaattatgg gcctcgtcca aagctcaggc ggaaaaatca 1193641 tggacggctc tattaaactc gaagacaaag acctcacctc attcactgaa aacgattatt 1193701 gcaaaatccg cggtaacgaa gtatccatga tctttcagga accaatgacc tcccttaatc 1193761 cggtgttaac aatcggagaa caaattaccg aagtgctgat ttaccataaa aacatgaaga 1193821 aaaaagaagc ccgtcaacga gctgttgaac tcttgcagat ggtcggtttc tcccgggcgg 1193881 agcaaattat gaaggagtac ccgcatcggc tgtccggcgg tatgagacag agggtgatga 1193941 ttgccatcgc actgagctgt aatcctaaac tgctcattgc tgatgaacca acgacagcgc 1194001 tggacgtgac aatacaagcc caggtgctgg agctcatgaa agatctctgt cagaagttca 1194061 atacatcgat tcttctcatc acacacgact taggtgtcgt gtctgaagct gccgatagag 1194121 tgattgtcat gtactgcgga caagtcgtag aaaacgccac tgttgatgac ttatttttag 1194181 aaccgcttca tccgtataca gaaggcctgc ttacgtcaat tcctgttata gatggagaga 1194241 ttgataaatt aaatgcgatt aaaggcagtg tgcctacacc ggataatctg ccgccggggt 1194301 gccgttttgc cccaaggtgc ccgaaagcta tggataagtg ctggacaaat cagccttcgc 1194361 ttttgacaca caaaagcgga agaacggtga gatgcttttt atatgaggaa gagggtgccg 1194421 aacaatcatg acagcagcta atcaagaaac aatcttagag cttcgtgacg taaaaaaata 1194481 ctttccgatc cggtcaggcc tttttcaaag aaaagtcggt gatgtaaaag cggtggatgg 1194541 tgtttcattt tcgttaaaaa aaggagaaac actcggaatc gttggagagt cgggctgcgg 1194601 aaaatcgact gccggcagaa cgatgatcag actgtacaaa ccgacagagg gccaaattct 1194661 ttttaaaggg caggatattt ccaatctgtc agaggagaag ctgcggaaga gtgtccgcaa 1194721 aaatattcaa atggttttcc aagatccatt tgcttcgtta aacccgagaa agaccctgcg 1194781 ttccatcata aaggagccgt ttaatacgca caacatgtat accatgcgtg aacgaaacga 1194841 aaaagttgaa gagctgcttg caagagtagg gcttcacccg tcgtttgccg gccgttatcc 1194901 ccatgagttt tcaggcggcc agcgtcagcg gatcggcatt gccagagcac tcactttgaa 1194961 tccagagctg atcattgcag atgagccggt ttccgcactt gatgtatcca ttcaggccca 1195021 agtgattaac ttgatggagg aattacagga agaatttaat cttacgtatc tatttatctc 1195081 tcatgatctg agtgtcgtcc gccatatcag cgacagagtc ggagtaatgt atcttggcaa 1195141 aatgatggaa ctgaccggca agcatgagct ttatgacaac ccgcttcacc catataccca 1195201 agcgctttta tcctccgttc cggttacaag aaaaagaggt tctgtcaaac gtgaacgcat 1195261 tgtcctgaag ggagaactgc ctagtccggc caacccgcca aaaggctgcg tattccacac 1195321 aagatgtcct gttgcaaaac cgatatgcaa ggaacaaata ccagaattta aagaagctgc 1195381 tcccagccac tttgtggctt gtcaccttta tagctaatgt tgcccgcaca gctttgagag 1195441 ggggtatgca cactacataa acaacagcct agaagaacga acatttcaag agggggaata 1195501 tctaatgaaa agacggaaaa ccgcactgat gatgctaagt gtattgatgg ttctggccat 1195561 ctttttatca gcctgctcgg gatcaaaatc aagcaacagc agcgcgaaaa aatcagcagg 1195621 caaaccgcag caaggcgggg atttggttgt tggttcaatc ggagaaccca cactttttaa 1195681 ctctctgtat tctaccgatg acgcaagtac ggatattgaa aatatgctgt acagcttttt 1195741 aacgaaaacg gatgaaaaac taaatgtgaa attgtcactc gctgaaagca ttaaagaatt 1195801 agacggcggc cttgcatatg atgtgaaaat taaaaaaggc gttaagtttc atgacggaaa 1195861 agaactgact gcagacgacg tcgtatttac gtacagtgtc cctttaagca aagattacaa 1195921 gggagaacgc ggttcaacat atgaaatgct gaaatccgta gaaaaaaagg cgattacgaa 1195981 gtcttgttta agctgaaata taaagacggt aatttctaca acaatgcgtt agacagcaca 1196041 gctattctgc cgaaacatat tctcggtaat gttccgattg ctgatttaga agaaaatgag 1196101 tttaacagaa agaaaccaat cggttcagga ccatttaagt ttaaggaatg gaagcagggc 1196161 caatatatta agctcgaagc gaatgatgat tactttgaag gaagaccgta tttagatact 1196221 gtgacgtata aagtcattcc tgacgcaaat gctgccgttg ctcagctgca ggcaggcgat 1196281 attaatttct ttaatgtgcc cgccactgac tacaaaacgg ctgaaaaatt caacaaccta 1196341 aaaatcgtta ctgatttggc attaagttat gtgtacatcg ggtggaatga aaaaaatgaa 1196401 ttattcaagg ataaaaaggt tcgtcaagcg ctaacaaccg ctcttgaccg cgagtcaatc 1196461 gtcagccaag tattagatgg agacggcgag gtagcttaca ttccggaaag ccctttatct 1196521 tggaactatc ctaaagatat agatgttccg aaatttgagt acaacgagaa aaaagcgaaa 1196581 cagatgcttg cagaagccgg ctggaaagat acgaacggtg acggcattct ggataaagac 1196641 ggaaagaaat tctcgtttac ccttaaaacg aaccaaggaa acaaagtccg tgaagacatc 1196701 gctgtcgtcg ttcaggaaca gctgaaaaaa atcggcattg aagtgaaaac ccagatcgtt 1196761 gaatggagcg ctctcgttga acaaatgaat cctccgaatt gggattttga tgcaatggtc 1196821 atgggatgga gtttatccac attcccggat caatatgata ttttccattc aagccagatt 1196881 aaaaagggtt tgaactacgt ttggtataaa aatgccgaag cggataaact catgaaagat 1196941 gcaaaatcaa tcagtgacag aaagcagtat tcaaaagaat atgagcaaat ctatcaaaaa 1197001 attgcggaag atcagccgta tacgttcttg tattatccta acaaccatat ggcaatgccg 1197061 gaaaatcttg aaggatacaa atatcatccg aaacgtgatt tgtataatat tgaaaaatgg 1197121 tggcttgcaa aataaatttc ccttaaaggg gagggagagc gttttctccc tcttctgttt 1197181 ttaataagga aagtaaaggg ggacaagtat atggctgcat atattatcag aagaacctta 1197241 atgtctatcc cgattttatt gggaattacg attttatcat ttgttatcat gaaagccgcg 1197301 cccggagatc cgatgacatt aatgatggac ccgaaaatca gccaggctga cagagagcag 1197361 tttattgaaa aatacggtct gaatgatcct cagtacgttc aatatttaaa gtggctaggc 1197421 aacatggtgc agggtgattt cggaacgtct attgtcagaa aaggaacgcc tgtttcagaa 1197481 ttgattatgg caagactacc caatacgctc ctgctgatgc tggtttcaac gattttggct 1197541 cttatgattt ctattccgtt cggtgtcctg tcggcaaagc ggccgtattc aaaaatcgac 1197601 tatggcatta catttacctc gtttataggc ctggctattc caaacttttg gtttggatta 1197661 attttgatta tggtgttatc ggtaaatctc ggctggtttc caactggggg tgtcgagaca 1197721 ctgaataccg aattcaatat atttgaccgg attcatcatt taattctgcc tgcattcgtt 1197781 ctagctacag ctgacatggc cggactgacg agatacacga gatccaatat gcttgatgta 1197841 ttaaatcaag attatattcg cacagcgaga gcaaaaggat ttaaagagaa cagagtgcta 1197901 tttaaacatg gattgaggaa tgcattatta cccgtcatta caattttcgg tttgatgatt 1197961 ccttcattta tcggcggatc tgtcgttgtc gaacaaattt tcacttggcc gggattagga 1198021 aagctgtttg tcgattcagc attccagcgc gattatccgg ttatcatggc aatgactgtg 1198081 atctcggcgg ttcttgtcgt tgtcggaaac ctcattgcag acatccttta cgcgattgtt 1198141 gatccgcgga tcgaatatta aaaggaggga aacagagatg tcagagctgc aaacaactcc 1198201 ctcgccggag atcaggctga aagaaaatat ttcgaaaaag ccagaaacaa tgacaaagat 1198261 tttctgggaa aaattctcga aaaacaaact ggccatttta ggtgccgtta ttctttttat 1198321 cattattatg tctgctgttt tcgccccttt aattgcacct tatccccaag agcagcaaag 1198381 cctgcttgat aaatataagg cgccgggcct tgaacatctg atgggaacgg ataaatttgg 1198441 acgtgatatt ttcagccgga tcctatatgg agcgcgtgtc tctttattgg ttggatttgc 1198501 gtccgtagtc ggttcgattt tgatcggaac ggttttagga gcattagccg gatatttcag 1198561 aggaatagtg gatgctgtca ttatgcgtgt agttgacatt gtgttatcca ttcctgatat 1198621 tttcttgttg atcacgctgg tcaccatctt caagccgggt gtggacaaat tgattttaat 1198681 tttctgtctc acaggatgga ccacaacagc acgattagta aggggagaat tcttgtcgct 1198741 ccgttcaagg gaatatgttc ttgctgctaa aacaattgga acaaaaacgc acaaaattat 1198801 tttttctcat atcctgccca atgcgttagg gccgattatc gtgtcagcta cgctgaaagt 1198861 tgggtctgtt attctagctg aatcggcgct aagctacttg ggctttggaa tccagccgcc 1198921 aatcgctagc tgggggaaca tgcttcaaga cgcacagaat ttcacagtaa tgattcaagc 1198981 atggtggtac ccgttatttc ccgggctatt tattttaatg accgttttat gcttcaactt 1199041 tgtcggtgat ggcctgcggg atgcgcttga cccgaaaaat attaaataaa aatgaatatc 1199101 atatctgtta taaaatatca ccaaatcaga aaaaagcagg tctcctttag tcagaaaata 1199161 tacaaagaga tctgcttttt atgattctta cataaaccca gtgattccag atttcctcaa 1199221 tctctttgga ataatttctc tatcccttgc ctatactgtg gacaacagtt tttataaaag 1199281 tgaggggtta gagatgttat ttcttcatga tgtgtgggtc aattggtttg aaggggaaga 1199341 aaatggctac aatgtatgcc actttcacga atggcgcaag gaagatacgg ttgagctttt 1199401 ggatcaggtg ccgctgttaa gggtgccgtc agtactgttt cattacatag aaaacgattt 1199461 gtcagagctt ccgaaaggtt tgcttgaaga cgtacatcag aaatcgtaca ttcgaaaaaa 1199521 tcatgagcgg acaaagcttg agtattgttt tgtcgtaaca gacggaatcg gcattttagc 1199581 tgttgacacg atcggctaca cgatccctgt cagaaaaagc cgtctaatcc caagacagga 1199641 gcagctcgtt tatgaaatgg taaaagatgt agagcctgaa acatatgaat ttgagccaaa 1199701 gaagctggaa tcctccaagg aatatcacat cttatcatta gcaccagaac atgtcagagg 1199761 actgacaaga aaagaacggc aaattaagca gctgatgttt atggcgcttg accaattaaa 1199821 agggctgaaa aaccgagcgg aaattggcta ctggtacaca gagtggaatc cgcatatgta 1199881 tgaacaaatc aaaaggatga gctttgaaga gatttgggac atgctgtata acgaaacaat 1199941 tgaaggctgg tcggacaaac acctagcttt ttgcgaaaac ctaataaaag gacagccttt 1200001 tttcgaaaag ctttgggaaa tggaaaacga atcaaaggtc aactgaaaaa aaccgctctt 1200061 tgcaaagagc ggttttttga ttagcgtctt tttcttccaa gacccatggc attctccatt 1200121 tttttcagca ttttgtttgc tgtccgattc gctcgttccg cgccttcatc aagaatccgg 1200181 tctaattctt cagattctat cagctcgtaa tagcggtcct ggatcggttt taatgcgttc 1200241 actacgactt ctgccaaatc acctttaaac tcgccgtagc cttttccttc gtactttgct 1200301 tcaagctctt caattgtcgt attgccgagg attgaataaa ttgtaagaag gttggaaacg 1200361 cccggtttgt tttccttatc aaatttgaca atgccttcag aatccgttac tgcgcttttg 1200421 attttctttt caagctgctt cggctcatcc agcaatgtaa tataagcttt ctgattcgga 1200481 tcagatttgc tcattttctt cagcggatca ttcagagaca tgatacgtgc accgactttt 1200541 ggaattttca cttccggaat cgtaaagatg tcgttgtatt ttttgttgaa gcgttctgca 1200601 agattccgcg tcagctcaag gtgctgcttt tgatcctcgc cgacaggtac aagatccgtt 1200661 ccgtacagca gaatatcagc ggccatcagc ggcggatatg ttaacaggcc ggagacgaca 1200721 gcttcattgc ctttggattt gtccttaaat tgagtcatcc gctcaagctc gccgatatag 1200781 gcgacacact gcatcatcca tccggcctgc gcatgtgcgg ggacctctga ctgaataaac 1200841 aatgttgctt tttctggatc aagtccgaca gctaagtaaa gcgccgcgag attgcggata 1200901 ttctttctaa gctcaagccg gtcttgagga acagttatcg catgctgatc gacgatgcaa 1200961 aaatagctgt tataatcatg ctgcagttcg acaaactgct tcattgcacc gatatagttg 1201021 ccgagcgtca ctgagccgct tggctgaatg cctgaaaaaa tcgtttgttt catgaaaaca 1201081 tcaacctcat ttcttaaaac ataataaaaa aggctcattc ttcccctgta aaaaagggac 1201141 gaatgaaccg tggtaccacc ctgattattc cattaaaatg gaatcactct gacgtttgta 1201201 acggagactg ctccggctga gcctactttt ttccagttcg gtcagctgct ccaaagtcca 1201261 ttccacattg cccgttatct gctcccagca ccgcagactc tcttcaaaca ggtgaaacgt 1201321 gtactactct ttttcatagc aagcttttct tttgattgct tcattataaa tcaattataa 1201381 ccaattgtca tcatgaaaaa acattctttt ttccagtaaa attgtaataa tataaataac 1201441 acgagtgctg taaaatcctt aaatgataac tgctatcagc gtaaaaacag gcagatatta 1201501 tatgtaaaaa gcaatatggg cagaaaacac atgaaaaagt ttttaatcaa tttatgcttt 1201561 aaatggtaga aggatattat gttcatggaa gaaaaactaa cgaagtttaa atattttaaa 1201621 ttgataaaat aatattgcaa taaattattt gtttcattat aatgaacttg ttcactctat 1201681 tgttacagct tttttacaaa aataatcaga aaagacggaa cagaataaaa gttgtggaaa 1201741 ctcaggttca tttgtctgat atttctgagg atttagccgt aaggagctga aaattattat 1201801 tagggggttt gcgaatatga aaaaacgttg gtcgattgtc acgttgatgc tcattttcac 1201861 tctcgtgctg agcgcgtgcg gctttggcgg cagcggatca aacggtgaag ggaaaaagga 1201921 cagtaaagga aagacgacac ttaacattaa tattaaaact gagccgttct ccttacatcc 1201981 gggattggca aatgattcag tatcaggcgg tgttatccgt cagacttttg aaggattgac 1202041 acgtatcaat gcagatggtg agcctgaaga aggcatggct tctaaaattg aaacgagcaa 1202101 ggacggaaag acatatacat ttaccattcg tgatggtgtg aaatggtcta atggagaccc 1202161 tgtaactgca caagattttg aatatgcttg gaaatgggcg cttgacccta ataatgaatc 1202221 acaatacgct taccagctct actacataaa aggtgctgaa gcggcgaata ccggaaaagg 1202281 cagcctagac gatgtggcag taaaagctgt gaatgacaaa acgctgaagg ttgaattaaa 1202341 taacccgact ccatatttca ctgaattaac tgcgttctat acgtatatgc cgatcaataa 1202401 gaaaattgca gagaaaaata aaaagtggaa tacaaatgcc ggagatgatt atgtatcaaa 1202461 cgggccgttc aaaatgacgg catggaaaca cagcggctct attactctcg aaaaaaatga 1202521 ccagtattgg gataaagaca aagtcaaact gaagaaaatc gatatggtta tgatcaacaa 1202581 taacaatacg gaactaaaaa aattccaagc tggcgaactt gattgggccg gtatgccgct 1202641 cggacagctt ccgacagaat ccctgccgac cctgaaaaaa gacggttctt tacatgttga 1202701 gccgattgca ggagtgtatt ggtacaaatt caacactgaa gctaagccat tagacaacgt 1202761 caatatccgt aaagctttaa catattcgct tgaccgtcag tcgattgtta aaaacgttac 1202821 gcaaggagag caaatcccgg caatggctgc agtgccgcct acaatgaagg gatttgagga 1202881 taacaaagaa ggatacttca aagacaatga tgtcaaaaca gcaaaagaat accttgaaaa 1202941 aggcctaaaa gaaatgggct taagcaaggc atctgatttg ccaaaaatca aattgtctta 1203001 caacactgat gacgcacacg cgaaaatcgc tcaagcagta caagaaatgt ggaagaaaaa 1203061 tttaggcgtt gatgttgagc ttgataactc agagtggaat gtctatattg ataagctcca 1203121 cagccaagat tatcaaatcg gccgtatggg ctggctcggc gacttcaatg atcctatcaa 1203181 cttccttgaa ttgttccgcg acaaaaacgg aggaaataac gatacaggct gggaaaatcc 1203241 agaattcaaa aagcttctga atcagtcaca aactgaaaca gataaaacaa aacgtgcaga 1203301 gctgctgaaa aaagcagaag gtattttcat tgatgaaatg ccggttgccc caatctattt 1203361 ctatactgat acttgggtac aggatgaaaa cctaaaaggt gttatcatgc caggtactgg 1203421 tgaggtttat ttcagaaacg catattttaa ataaggctac gtctgaaaat aaaagacctc 1203481 aaggtatatg gggagaaaag ccccatatac ctttcttact gatggagtat aaaaatgtaa 1203541 aaaccatgga ggtgttcccc cttgctaaaa tatatcggaa gacgcttagt ctatatgatt 1203601 atcacactat ttgtgattgt aactgtgaca ttcttcttaa tgcaagcagc accgggcggg 1203661 ccattttcag gtgagaaaaa gcttccgcct gaaattgaag caaatttaaa tgcgcattat 1203721 ggcttggaca agccgctgtt tgtacaatat gtcagttatt tgaaatcagt tgcaatgtgg 1203781 gatttcggac cgtcatttaa atataaaggt cagagtgtta acgacctgat cagttcaggt 1203841 ttccccgttt catttactct tggagcagaa gctattctcc tcgctttagc gttaggtgta 1203901 ttgtttgggg tcattgcagc cctttaccat aataagtggc aggattatac cgtcgcgatt 1203961 ttaacgatat ttggtatttc ggttccgagc tttatcatgg cggctgttct gcaatatgtg 1204021 ttctccatga agcttgggct gtttccggtc gcggggtggg attcctgggc atacaccttt 1204081 ttgccttcca tcgcacttgc ttccatgccg atggcgttta ttgccagact ttcccgttca 1204141 agcatgatcg aagtgttaaa cagtgattat atccgcacag cgaaagcgaa agggctttcc 1204201 cgcccagcgg ttacagtgcg gcacgccatt cgaaacgcac ttttgccggt tgttacatat 1204261 atgggcccga tggccgcaca ggtcttaacg gggagcttca ttattgaaac catttttggg 1204321 attccggggc ttggtgcaca cttcgtcaac agtattacaa accgtgatta tacggtcatt 1204381 atgggtgtaa cggtgttctt cagtgtcatc ttgctattgt gtgtattaat cgtagatgtg 1204441 ttatacggca ttattgatcc aagaatcaag ctttccaaag caaagaaagg agcctaggcc 1204501 atgcagaaca ttccaaaaaa catgtttgaa ccagccgcag cgaatgccgg cgatgcagaa 1204561 aaaataagta aaaagagcct ttccctctgg aaagatgcga tgcttcgctt ccgcagcaat 1204621 aagcttgcaa tggtcgggct tatcattatc gtacttatta tccttatggc aatttttgcg 1204681 ccgatgttct caaggtatga ttattcaact actaatctct taaatgcgga taagccgcct 1204741 tcaaaagatc actggttcgg aacagatgat cttggacggg acattttcgt ccgtacatgg 1204801 gtaggggcgc gaatctcaat ctttatcggt gttgcagctg ctgttctcga tttgctgatc 1204861 ggcgtcattt gggggagcat ttcaggcttc cgcggaggaa gaacagatga aatcatgatg 1204921 cgtatcgctg atatcctttg ggcagttcct tcattattaa tggttatctt actgatggtt 1204981 gttcttccga aaggtctatt tacgattatt attgccatga cgattacagg ctggattaat 1205041 atggccagaa tcgtgcgcgg acaagtgctg cagctgaaga atcaggagta tgtgcttgct 1205101 tcacagacac tgggtgcaaa aacatcccgt cttctattta aacatatcgt gccaaacgca 1205161 atgggttcta ttttggtcac gatgacactg acagttccta ctgcgatttt tacagaagcc 1205221 tttttaagct atttgggact tggtgttccg gctccgctgg caagctgggg aacgatggct 1205281 tctgacggat tgcctgcatt gacctattat ccgtggcgtt tattcttccc tgccggattt 1205341 atctgcatta caatgtttgg ttttaacgtt gtcggcgacg gattaagaga cgcattggat 1205401 cctaagttac gtaaataagg gagtgatacg ggtgacacgc ctattagaag taaaagattt 1205461 agcaatttca tttaaaacat atggcggaga ggtccaggcg atccgcggag tgaatttcca 1205521 tctggataaa ggggagacgc tggccattgt tggagaatca ggttccggaa aaagtgtaac 1205581 ctctcaagcg attatgaagc tgattccaat gcctccgggt tatttcaaac gcggtgagat 1205641 cctgtttgaa ggaaaggatc tggtgccgct gtccgaaaaa gaaatgcaaa atgtccgggg 1205701 aaaagagatc ggcatgatat tccaagatcc gatgacctct ttaaatccaa cgatgaaggt 1205761 cggtaaacaa attacggaag tgctttttaa acacgaaaag atctcgaagg aagcggctaa 1205821 aaaacgcgcg gttgaactgc tggaattagt cggtatccca atgccggaaa agcgggtgaa 1205881 ccaatttccg catgaatttt caggcgggat gagacagagg gttgtcattg ccatggcgct 1205941 tgcagcgaat ccgaaacttc tgatcgccga tgagccgaca actgctcttg atgtaacgat 1206001 tcaagcgcaa attttggaat taatgaagga tttgcaaaag aaaattgaca cgtccatcat 1206061 ctttatcaca cacgatcttg gtgttgtggc taacgttgct gaccgggtcg ctgtcatgta 1206121 cgcgggacag attgtagaaa ctggtacggt agacgaaatc ttctacgacc cgagacatcc 1206181 gtacacttgg gggcttcttg catccatgcc gacactggaa agttcaggag aggaagagct 1206241 gactgcaatt ccgggcacgc cgcctgattt gacaaacccg ccaaaaggag atgcttttgc 1206301 cctgcggagc tcttacgcga tgaaaatcga ttttgaacag gagccgccaa tgtttaaggt 1206361 atccgatact cattatgtaa aatcgtggct gcttcatcct gacgcgccaa aggtagagcc 1206421 gcctgaagcg gtaaaagcga aaatgcgtaa actggcaaac acgtttgaaa aacctgtctt 1206481 agtgagagaa gttgaatgaa ttgactgaaa aactattaga aatcaaacat ttaaaacagc 1206541 actttgtcac gccgagggga acggttaagg ctgtagatga tttatcattt gatatctata 1206601 aaggtgaaac attagggctg gttggtgaat ctggctgcgg taaatcgaca acaggccgaa 1206661 gcattatcag gctgtacgaa gcaaccgatg gtgaggtgct gttcaacggc gaaaatgtgc 1206721 acgggagaaa atcgcggaaa aagctgctgg aattcaaccg caaaatgcag atgattttcc 1206781 aagaccccta tgcatccctg aatccgagaa tgacagttgc tgatattatt gctgaaggcc 1206841 ttgatattca taagctggca aaaacgaaaa aagagcggat gcagcgagtt catgaactat 1206901 tggaaacagt gggattgaac aaggaacacg cgaaccgcta tcctcatgaa ttttccggcg 1206961 gccagcgcca aagaatcggg attgccagag cgcttgctgt tgatccggaa ttcattatcg 1207021 cggatgagcc gatttccgct ttggatgtat ccattcaagc gcaggtcgtg aatttaatga 1207081 aagaactgca aaaagaaaaa gggctcacat acctgtttat tgcccacgat ttatcgatgg 1207141 tcaaatacat cagtgaccgc attggcgtca tgtatttcgg gaaactggtt gagcttgcgc 1207201 cggcagatga gctttatgaa aatccgcttc acccatatac aaaatcattg ctttctgcga 1207261 ttccgcttcc tgatccggac tatgagagaa atcgcgttcg ccagaaatat gatccgtctg 1207321 tccatcaatt aaaggatggg gaaacgatgg aattccgtga agtcaaaccg ggacattttg 1207381 tgatgtgcac ggaagccgaa tttaaagctt tttcatgatt catcaatcct tcaagagatt 1207441 tctcttgaag gatttttttg cgtcttcata gaaagtgaga atgataacat ttacaattag 1207501 aggaaaaagc ggaggcgaaa tacgattcaa tttctgcata acaaaaatgt ttttgcgcta 1207561 ttgctgtctc aatcttttca atctttagca ggagtcctcg tcacaatcgt tttaatggtc 1207621 cggatctatc aaatgactga ctccgttttt ttggcgggcc ttattttatc gttcatgtcg 1207681 tttgcgagta tagcagcaag cttttgcgtc tctccggtgc ttcgcattct cggttttaaa 1207741 aaggtgcttg cgggagcgaa tctgctgaga gcggtcttta ttatactgat ggcatacagc 1207801 gtcactcatc acggacaggc attcttttgg attacgctgc tgtttgtgtt ttgtttttcc 1207861 ttcgcgggcg ctttttttca gccggcaaga tttgcgctgc tgccgattat tgttccaaag 1207921 aagcaatatg taaaagcgaa tggtgtgatc tccctctcga atcaattgtt cttaacagca 1207981 ggctggggcc ttggaggcct tctgacgtac gccgtccctt ttgaactcgt tgtcggcgct 1208041 gccatttgcc tgtttgttct atcgggagct tccatcagtg tgctgcatgt aaatgaagaa 1208101 gaggctgcag gaactgctga aacagcatct gtcagaagta tatggaagga tttaatgatc 1208161 atccctattg taagagacat tactgtaatg gacatgttag aagctttggc gggttccgta 1208221 tggtcatctg ctattctcct cgcatttact gcggctgttt tgcatgaaac agaggtgtgg 1208281 tgggggatgt ttaacgcttc ctattttata ggcgcaattg tcggcagtgt gattgctatt 1208341 cgtttttctt ctttttttga gcggaatatg ggctatgcca ttatgttcag ctcgcttgta 1208401 atgtcggcgc tgaccctttt gttttcattt tctccagtcc catttttatg cgctctggct 1208461 tgtgctgcaa tggggccttt ttatcaggtg cgtgatattt gccaggaaac catgctgcag 1208521 gaagttattc ccgagcagaa acgaatcgga atcatggctg caaaaaatgc gattttgact 1208581 ccttggtcag gcgtcaccta ctccattatg gggctagtgg ctgatgctgc tggtgcgaaa 1208641 atagctttta tcgcggctgc tgcattatat atcatgacat ttctgattgc actggcgcag 1208701 ccccgtctgg ttcattacag gcgagaaaat cgagttcaat gagaaacact tcaaaatgaa 1208761 cggagcagct ggctccgttt tgctgaaaaa aaaatgaaac catggcggaa gttcgcacgt 1208821 ctttatagat gtaaggctgt ttaaacaaga agaaatgggg tatatctaaa agtatgaaga 1208881 caacgaactc ataaggagca aatcaatgaa ctggtatgaa aagcttagcg agtactttcc 1208941 aattgaagaa atgaaatcaa aagcgcatat ggaagctctt ctgaaagagc gaagcgatat 1209001 ttatcataaa gatgaaggca aacatcatat tttaatgttt gcggaattcg attcttttat 1209061 cttcgttgat tatctgtatg tgtctaagga tgcaagaggg caggggcttg gcggcaaatt 1209121 gatcgcgaag ctgaaaaaga aaaataagcc catattgctc gaggtggaac ctgtggatga 1209181 agatgatact gatacagaaa aacgcctgag gttttatcaa agagagcatt tcaagcatgc 1209241 tcagtcaatt gggtaccggc gccggtcatt ggctacgaat gaagtaaaca agatggagat 1209301 tctgtactgg tcaccaaaaa cagaatcaga agaagaaatt cttgaagcca tgaaacagac 1209361 atatgaaaac attcatactt ataaagatga gaaatggtac ggagaatcgt acgaaaaaac 1209421 ggatgaggtc ttggaaatca tcgatgaaga aaaacaaaaa aatattttcg atcagttaag 1209481 ctaattgaga ataagaacat atcatgaaca ttaaaaattt gctggattga cacatttttt 1209541 tcttaggata ctgttcacac ttactttttt atagtataat acctgtaaag attccttttt 1209601 tagagtaatt tcaatttaag aataaaatag atgttcatcc tactaattag aggagtgaag 1209661 atgaatggtt acactataca catcaccaag ctgtacttca tgcagaaagg cgagagcgtg 1209721 gctcgaggag cacgagattc catttgtaga aagaaacatt ttctctgaac ctttatcaat 1209781 tgatgaaata aaacaaattc ttcgaatgac tgaggacgga acagatgaaa tcatctcaac 1209841 ccgttcaaaa gtattccaaa aactgaatgt gaacgttgaa tctatgccgc tgcaagattt 1209901 gtaccgcttg atcaacgagc atccaggttt gcttcgccgt ccgatcatca ttgacgaaaa 1209961 acgtttgcag gtcggatata acgaagacga aatcagacgt ttcctgccaa gaaaagttcg 1210021 ctctttccaa ttaagagaag cacagcgttt ggcaaactaa tagatcgtat catcaaaaga 1210081 aggctgagtc atcagccttc ttttattttt caacctgctg gtaataaatg ctcgcaagga 1210141 tgacaaacgc aaccgtcaaa atggggagga gcgtttcgac tgtgccgtgc tgcgccataa 1210201 aaagcgacag ctttttgtct ctgacaatca tttctccgcc agtataagca agcagcccgc 1210261 ttcccgcgta aatcagaagc ggtattttct ctagtgcaat atggatgagt ttgctgcccc 1210321 aaataataac cggaaccgat acacacaatc ctataacaac gagagaaaac tcaccgtgtg 1210381 aagctcccgc aactgcgatg acgttgtcca gcgacataaa gagatctgca agcacaatcg 1210441 ttcgtatcgc tctccacagg gaggtgctgc ttttaatgtg tttcgtgtct tttttttcaa 1210501 tcagcagctg atatcctaaa tacagcagga aaattccgcc ggcgcactgc aagaacggaa 1210561 tgttcaaaag atatactgct gcacttgtta atccgattct catggcaacg gcaataaatg 1210621 ttccgagaat aatggcttgc tgtctttgct tgtccggcaa atgtctgctg gccatggcaa 1210681 taacaaccgc gttatctccg ccgaggatca ggtcaatccc aacaatgacg agcagagaaa 1210741 tcagatagtc atgctccatg aagcggcacc tcgctttcag tccttcgctt gtactactac 1210801 tatatgagac aggtcatatt ttatgatatc agccgcctga tctgccgttt tttaggcaaa 1210861 ggtgcatttt tatttctttt gtgactgttt tatcataaaa tagaaataca aaggaattca 1210921 cactggcctt ggttaaggtt aagatgtgga cggaatgggt aaagtgtagt aaagtacaat 1210981 taatcgggag cttagatgtc ccttcaacat cttatataga agggaaggtt ggcaaatgga 1211041 aattgaaaga attaacgagc atacagtaaa attttatatg tcttacggag atattgaaga 1211101 tcgcggtttt gacagagaag aaatttggta taaccgtgag cgcagtgaag aacttttctg 1211161 ggaagtcatg gatgaagttc atgaagaaga ggaattcgct gtggaaggcc cactttggat 1211221 tcaagttcag gcactggaca aaggattaga aatcatcgtc acaaaagccc agctttccaa 1211281 agacggacaa aagctcgaac tgccgattcc tgaggataaa aagcaagaac cagcatctga 1211341 ggatcttgac gccttgctgg atgatttcca gaaagaagag caagccgtca atcaggaaga 1211401 gaaggagcaa aagcttcaat ttgtcttgcg atttggcgat tttgaggatg ttatttctct 1211461 atctaaattg aacgttaacg gaagcaaaac gactttatat tcgtttgaga accgatatta 1211521 tttatatgta gatttttgca atatgactga tgaagaggtt gaaaatcagc taagcatcct 1211581 gctggagtac gcaactgaat cctcaatcag catacaccgt cttgaagagt acggcaagct 1211641 gattatttca gagcatgctc tagaaacgat aaaaaaacac tttgcatcat agcaaaccga 1211701 tttccttccg gaaatcggtt ttttttatgc acgaaaatgc cattttagag atgtgaaaaa 1211761 tcaaaaacat atagacaagc agaaaataca gcgaacagga gttgatcatc ttttccagaa 1211821 agtatacttc atctggaaag gagagatgac aattgtttag tgctgtgact gaagacggcc 1211881 aaatgtttca ccttctaggc gctcagcaaa accagaaatt aaagcggaga cggttcttct 1211941 gtccggtatg cgggggagag ctagctgtga agctcggact tcaaaaagcg ccgcattttg 1212001 cccataaaca gaacaagtcc tgcgccatag acatcgagcc ggaaagcgcc taccacttag 1212061 aaggaaaaag acagctgtat gtatggctga aaacgcaacg ggcttcacca atattggagc 1212121 cgtatataag gacaatcaac caaagaccgg acgtcatggc aagaatcaag gagcatatgc 1212181 ttgctgttga atatcaatgc gccactatcg ctccagatgt ctttcaaaag cggacagagg 1212241 gcttcaaaca agaaggaatc atcccgcagt ggattatggg atacagccgc ttaaaacgga 1212301 ctgcttcgtc cttttatcag ctttcaactt ttcattggca gtttatcaat gcaagtccat 1212361 acagagaact gatatgttat tgtcctgaaa ggcgttcttt tctccggctc agccacatca 1212421 ttccattcta cacaaaccat tcttattcct cagtccaaac gatccctatc catcgggcag 1212481 gtgcaggcga tctttttttc actgaaccga aaccctcaat tcaatattca ggctggacga 1212541 aagcgattca ccgttttcgc cataaacccc atcggtttaa ctcaaaggaa acaaatcgcc 1212601 ttaggctgct gttttatgag aaacgacaga cgcctttttc ttttctgccg actgaagtgt 1212661 ttgttcctgt tagaaaaggg gcagttttta agagtccggt ttttgtgtgg caggggtttc 1212721 tttatttgtt tatgacggat cttggaggta aacgtgcgcc aattcgtttt tcagccgttt 1212781 tgcagcagtg caaactgcac attcataata agaacattgc actcaggtcc gaatgcagcg 1212841 aagagtgtct ttcagaagcg gttaaacagt atattgattt tttgtgcaag aagggatttt 1212901 taagggagac tcagaaagaa gtatatgtgc tgaatcagcc tgcaggaggc atacactcca 1212961 tgcaggatct catagaaaga gaccgcagct gttttataga atgagtttgt cttatttggc 1213021 tcaccctaag acaaaggtgg tgggcaggct gtgaaaggca caaaaggaaa ggtttttcgt 1213081 gtttttactg cttttttggc attcgttctc ttcattactg catatgattt gacaaaaggc 1213141 agtgaaaaac cggaagatat tcacaacaca agtttattga gaaacagctg ttttttcaat 1213201 tggcttgaat caaagaagac gagggggatc accatggctg aggaaaaaaa agcaaaccaa 1213261 ctgcctgaca gaagtgaggt aaaggcagaa gacacatgga gacttgagga tatttttcct 1213321 agtgatgagg cctggaataa agaatttcaa gctgtaaaag aattaattcc gaatttatct 1213381 aagtataaag gaaagctggc agattcagct gatcatttat acgaggctct tacgtatcaa 1213441 gataaagtga tggagcggct aggtaggctg tacacatatg cgcatatgcg ctctgaccag 1213501 gatactggga actcctttta ccaggggctg aatgacaagg cgggaaacct gtatacacag 1213561 gccgcaagcg cgacagctta tttggttccg gagattttat ccatagaaga agacaaactg 1213621 cagcagttca ttcttgaaaa agaagaattg aagctgtact ctcatgcgat tgaggagatt 1213681 acaaaggaac gtccgcatgt gctgagcgag aaggaagagg cgctgcttgc tgaagcctcc 1213741 gaggtactgg ggtcatcttc aaatacattc agcgtgttaa ataacgcaga tataacgttt 1213801 ccatccatta aagacgaaga tgggaatgaa aaacagatca ctcacggcaa ctttattaat 1213861 ttcttggaaa gtgaaaaccg tgaagtccgc aaaaatgcgt ttgacgcagt gtataaaacg 1213921 tacggacaat ataaaaacac aatggccacg acgctaagcg gcactgtgaa aaaggacaac 1213981 ttctacgcga gagtgaaaaa gtacaagtcc gcgcgtgagg ctgcgctttc taacaacagt 1214041 attcctgagg aagtatacga taaccttgtt aagacgatta ataagcattt gccgctcctg 1214101 caccgctata ttgcgctaag aaagaaagtg cttgagcttg atgaagtgca tatctatgac 1214161 ctgtatacac cgcttgtgaa agatgctggg atgaaggtga catacgagga agccaaagat 1214221 tacatgctga aaggcctcgc acctttaggg gaagaatatg cctctatcct aaaagaagga 1214281 ctggaaaacc gctgggtgga cgtttacgaa aataaaggca aacgcaatgg ggcttattca 1214341 tcaggagctt acggcacgaa tccgtatatt ttgatgaact ggcataataa cgtcaataat 1214401 ctctttacgc tcgtgcacga gtttggacat tccgtacaca gctactatac gagaaagcac 1214461 cagccttatc catacggcaa ttacagcatc tttgtcgcgg aagttgcctc tacgacaaat 1214521 gaagcgctcc ttggcgaata tttgctgaac aatttagagg atgaaaaaca gcgcttatat 1214581 attctcaacc atatgcttga gggcttcagg ggaacggtct tcagacaaac gatgttcgct 1214641 gaatttgaac atctgattca tacaaaggcg caagaaggcg agccgcttac acctgagctt 1214701 ctgacaaatg tctattacga cctgaataaa aagtattttg gagacggcat ggtgattgat 1214761 aaggaaatcg gccttgaatg gtcgcgtatt ccgcacttct attacaatta ctatgtgtat 1214821 cagtatgcga caggttacag cgctgcccaa gcattaagca gccagatttt gaaggaagga 1214881 aagccggcgg ttgaccgtta tattgacttc ctgaaagcgg gaagctcaca atacccgatt 1214941 gatgtcctga aaaaagcggg tgttgatatg acgtctccag agccaatcga agccgcgtgc 1215001 aaaatgtttg aagaaaaact tgatgaaatg gaagagctgc tgatgaaagt caagcagtct 1215061 taaaaaagta agcctgtgcg gaaatgacgc acaggctttt ttaaaaccct ttaaaggttt 1215121 tccggtgatt caagcggtag agggtaaaca aaatagacag aaacagcaga ggagaggtaa 1215181 tataaagcgg cagcatatgc atcatgccta agatattcaa gcagaaaaaa acagcaatgc 1215241 acacaattga gatcaaagta gacatcatgg cggtcctcct cgtccttttt ccttataagg 1215301 atatgagtga atgcacttcg ttatgttttg tgacaaaaat atgaacatta agcatagagg 1215361 ttgtcaaaag tcgacatctt ttgttatcat aaggatgtga aattgatcac aaacaaacat 1215421 tacccctttg tttgaccgtg aaaaatttct cccatcccct ttgttgtcgt taagacatat 1215481 gaaaccgcgc ttatcccggc gcggtttctt tagtgctaaa aatggaacgt acgtttggtt 1215541 atggcataaa aaaacagcct caagcatatg cacgcctgcg gctatttttc acatgattga 1215601 tattcatcag aataagtgct gagagacttc caaaacattc cgtgtttggc ttccactttg 1215661 gcaacctttt tagcaaacgc cagttttttc atttcttttt ctacctcttc aaggctcagg 1215721 tcatatacaa gagcaatttc cttcgaggca acgaagcgga aatattcaat aaaacattct 1215781 aaaggcggtg tttccgacgg cttcggctcg tcgccaagca tctcaaataa aatttcttca 1215841 tatacatcat atgagtagct gccaggaact ttaagccctt catcctcatg ctgcgtatta 1215901 aaaaacgtca gtgtcggatt aacagaaaca tccatctcgg cagcaatttt catgtcacat 1215961 tgaagcgcct tgaccgcgct ttgagaatgc agatcttttt tgaattcttc aagatcgaga 1216021 cttgtatttt cagcaatctc caaaagcacg ttttcatccg taatattttt ctttgaaaca 1216081 aataggctct cctgcatatt tctgagaaat tgcatgccgg cttttcgtcc ttgcagttcg 1216141 gctgctttaa aagcgagagc agccatataa ggcgatgaaa gcggctgatc ctgttcgaac 1216201 cagacattgc cgtcacatga catgccagag cggctcgcga tcttttccca tgcttctgcg 1216261 agaagatgct tttttcgctt tttatttaaa gcggtaaggc ttgcggaagc gataatgcgt 1216321 aaggtgaaaa aacgtccgta tctgattttc agctttttga tgacgggctc taaggaccag 1216381 cattcaggac ataaagggtc tacaaacata taaatttcaa gcggtttttt tggatgaccg 1216441 tggcaatggg cgaagtatag ctcatgctga tagtttgtca agatgatcga tcctccgctt 1216501 ccgtttgatt caccatatgc cttgctgtca actccagccg gccaaacaaa aactcacgaa 1216561 tttcgccctc cagccctaca tggtccattg cgtccttcat acagctgagc cacgcatcag 1216621 ctctctcgtt tgtaattgga aagggaagat gccttgctct gagcatagga tggccgtgtt 1216681 cctcagtata aagaggaggc ccgcctaaat actgagttaa gaattgcttc tgtttcctgg 1216741 cggtttctgt caaatcgctt ggaaaaatcg gcttcagcaa aggatgagac gcgacacgct 1216801 cataaaaagt atcaacaagt tgcgatagaa gttcctctcc aatcgcttca taaggtgcgt 1216861 taaacgattg tcccatgttg actactcctt taaatatggc taataggaat cataaatcct 1216921 attgcaaaaa gtaattttct gtatttcatt gtttcatcta gatttatttt agcaacaagg 1216981 catcatttct acaaacaaac tgccttttat gcgtttgatg actcatttcg gctgacagcc 1217041 ggggtttgta tttcatatca tatcacataa aaatcaggaa tgcgtaagat ttcacttcgc 1217101 aaaaaaacca gagggaaaga gcacctctgg ttacgcgtaa taaactgaag ttattttttt 1217161 tacatagttt tgcgtttctt ggaaaggagg aatgcctccg tatcggtcaa cattccccgg 1217221 tccggcgttg taagccgcta atgccataga cacattgccg tcgtatttat ccagcatttg 1217281 ttttaaatat ttcgttccgc cctccacatt ttgctgcgga tcaagcggat tggaaacgcc 1217341 aagtgagctt gctgttgacg gcatcagctg catgaggccc atcgcacctg ctccgctgac 1217401 cgcttttgca ttaaagcctg attcctgttt gatgacggcg cggatcagtt tttcatcaac 1217461 gccatattta tcagcggctt ttttaatcgc actgtcaata gagaagtctc ccgaacggat 1217521 ctgatttgct tcatgtttgt ttgaagctga atctgcaaca gctgtttcag tgctttctgc 1217581 cgcttttgtg actgaacctg aattgctgct cgtatatgag ttaagcccat acgctgaaag 1217641 cagtgacggc gctgttgtat tcgcgctgtt cagcatgctg agcgggcttg gcgatgaaga 1217701 aggtgctgat tgctgagatg tcagaccgtt tgtatattgg ctgagcaaag aactgaaact 1217761 tgaaagcggg ctttccgtat tctgagtgtc cgagctgctg cgtgcattag atatggactg 1217821 taatgcctga agctgaagta atgctgccca attcgttaca ttcacgatgt cattccacct 1217881 tatatagact ttcgtttttc ttcataaaaa cgcagaattt tatttttggt ttcgcgctga 1217941 ggaatgctga attgctgaag cagcttttcg aaggcttgtc tgccctcatg ccaatccgcc 1218001 gcctcaaatt caatttcata gtcctcttta tttaaatatc ggctgtggtc taaaactatt 1218061 aagccttttt ctgtttcttt ttccgcacgg tttgttgcta aagatccaaa gtattgtatg 1218121 gcatccgtat cgatctgaag cttgtgcagc tggtccttca cagggccctc gggaactgaa 1218181 aatccagcga gatctgatac ctctgaaagc tgctggtgcg tttccagaag ccccacatca 1218241 gccggctcct ttaatgtaag gacatacttt ccgttttttc tgcggatacg aagcgcagca 1218301 tgtttttgtt tcagcgcgaa gctgtctgta tcaaaataat gattcttttg atctgtaaaa 1218361 tctttttctg tcagctggag tgccgatgct atgtttttga attcttgttt ggtcagcatg 1218421 tttttaaatt cgatttcaat ctcttggctc atgatgctct tcctttccgc cctgtaaatc 1218481 ttatttttac tattatctct ttagatgtta ggtttatcaa tatcgagctc gatatgataa 1218541 aatgaatctg tactttgttt aaaaaaggag agcattatgc aaaacagaat cgaaattttg 1218601 aatgcaacat tatcggatga tcagcttcgc cttgcctgtc agacagaagg aaacgaagcg 1218661 gaacgcaagc cgtcaggtca aatgcttgtt gattctgacc actttgcttt tgtatacata 1218721 cttgaattag ctgattcttt tgaatatgtc attataaagg aacatgtatg gccggaactg 1218781 aagcaggccc atgcacaaaa aataccggtt gttttagagg caggagacca aacaattgaa 1218841 ctggcaggcc tgcatgagga gctggaatat cttttagaaa atataaaaga taatgcaaac 1218901 tatggagaag aaatggaaga aaaagtgaaa cgcgtgtttt tatagaaact ggttcggaat 1218961 tgggggatgt atgatggatg acaaacaatg ggagcgtttt ttagtgccgt accgccaggc 1219021 tgtcgaagag ttgaaagtga agctcaaggg gatccgcaca ctatatgaat acgaggacga 1219081 ccattcaccg atcgaatttg tgaccggacg cgtcaagcct gtggcgagca tacttgaaaa 1219141 agcgagacgg aaaagcatac cgctgcatga aattgaaacc atgcaggaca ttgctggcct 1219201 tagaatcatg tgccaatttg tcgatgacat ccaaatcgta aaagagatgc tttttgccag 1219261 aaaagatttc accgttgtgg atcagaggga ttatattgcg gaacataaag agagcggata 1219321 ccgatcatac catcttgttg tgctgtaccc tttgcagacg gtatccggag aaaagcatgt 1219381 tctcgtagaa atacagatcc gtacactggc gatgaatttt tgggcgacca ttgaacattc 1219441 attgaattat aaatacagcg gaaacattcc tgaaaaagta aaactaaggc ttcagcgcgc 1219501 ttctgaagcg gcttcccggc ttgatgaaga gatgtcggag atcaggggtg aagtacagga 1219561 agctcaagct gccttttcaa gaaagaaaaa aggaagcgag caacaatagg taaaggggaa 1219621 gaagagcatg aaatttgccg tatcatcaaa aggagatcaa gtttctgata cgctgaaaag 1219681 caaaatacag gcgtatttat tggattttga tatggaactg gatgaaaatg aaccggaaat 1219741 cgttatttca gtcggaggcg acggaacgct tttgtatgct tttcacagat acagcgaccg 1219801 tttggacaaa acagcatttg tcggcgttca cacaggtcat ctgggttttt atgccgactg 1219861 ggttcctcat gaaattgaaa aacttgttct tgccatcgcg aaaacgccgt atcatacagt 1219921 cgaatatccg cttctcgaag tcattgtgac ctatcacgaa aacgagcggg aagaaagata 1219981 cttagctttg aatgaatgta cgattaaaag catcgaagga agccttgttg ctgatgtgga 1220041 aatcaaaggg cagctctttg aaaccttccg gggcgacggc ctctgcctgt caactccatc 1220101 aggcagcaca gcctacaata aggcgctggg cggagcgatt atccatccgt ctatcagggc 1220161 gatccagctt gcggaaatgg cttcaattaa taaccgcgtg ttccgtacgg tcgggtcacc 1220221 tctgcttctc ccatcccatc atgattgcat gattaagccg agaaacgaag ttgactttca 1220281 agtgacgatt gaccatttaa cccttctcca taaggatgta aagtcgatcc gctgccaagt 1220341 tgcatccgaa aaagtgcggt ttgcgagatt ccgtccgttt ccattttgga aaagagtcca 1220401 ggattcgttt attggaaaag gtgaatagaa agaggacata tcgtggagca tttttttatc 1220461 agaaagaaca ttacttccgc tgaggacggg atgactgtaa aagaatatgc cggtgaactg 1220521 ggaatttcga aacgtctgct gaccgatatt aagtttggcg ggggagacct gcagattaac 1220581 ggtgagcatg tgacggtcaa atacgttttg aaagagggag atcttcttat cgtgaagttt 1220641 cctgaggagc aggtgagcga gacgctgttg gcagagcctg ttccgctcga tatcctttat 1220701 gaggatgaac atgtgcttgt gataaacaag cagccgtatg tgtcatcaat cccttcgaga 1220761 gagcacccct ccggcagcat tgccaatgga attattgatc attatcaaac aaccggagtg 1220821 agggcgacag ttcatcttgt cacccggtta gaccgggata catcaggtat catgcttgtt 1220881 gccaagcatc gatttgccca ctccatttta tcgtctgcgc aaaaaaacgg ccttgtgaaa 1220941 cgccggtatg cggcagtggt tcacgggcgg atggcacaga tggagggaac agtcgatgct 1221001 ccgattggca gacatcctga cagtattatt gaacggacgg taacgccaga cggccagaag 1221061 gctgttactc atttttacgt cacatgtgca aatgatgaca tgacctcggt ggcattgcag 1221121 cttgagactg gacgaaccca tcaaattcgt gttcatatga gctatctcgg gcacccgttg 1221181 tgcggcgata cactgtacgg cggaacgaga caggaaattg gccggcaggc tctgcacagc 1221241 gagcatcttt cgtttatcca tccgctgaca caggagaaca tgaggtttca tgctccactg 1221301 cctcaggaca tgagcaaact gataaaagga gagaatcatt gattctctcc ttttttatat 1221361 ggggcgaaat cttgattcgt cgtaaggcag ggagcttgga acagagacgg tttctatttc 1221421 tggaaagcga aagcctgtca gttgatttcc gaacacgcag cctgtatcaa tgttgatggt 1221481 gcgattgacc ttccgaggct ctttcacagg tgtatgaccg tataccaccc aagcctttcc 1221541 gttataggct gccgcccaat cacgcctgat gggtctgccg tccggatatg tttcacccgt 1221601 cacgtcaccg taaagcacaa agtccttcac tctgcgggta tatttgccga tatcgtcagc 1221661 tcttatgcca gcatgggcga caactaattc tccattatgt aagatgtcgt aaagcggcgc 1221721 tgtttcgtac agcttcataa actgttcgct gactgatttt ttctcatctt tggaaagttc 1221781 ctcaagctct gccgctgttg tttcgagacc atgcatcact tttaccggat ttccttttaa 1221841 gtaacgatat aatttattgc aatggtttcc cgggacataa cgcacagcgc ctttttcgta 1221901 agcgccggct acaaatcgga tgacctctat cgatttgggc cctctgtcag ttaaatctcc 1221961 ggcaaaaaca agcaccctgc cttcttcatg gacaggtact ccatttttga ttgtatagcc 1222021 aagcttttgg attaatgcag tcatttcgtc atagcagcca tgaatatcgc tgatgatatc 1222081 gtaagccatg cggtctcctc cttaccgatt gttttattta ttatgaagca aagtgttgtg 1222141 agtcatcaca agcttttatg tgcaaattat agaagaagaa tcattttcta aacaggatta 1222201 agaccttatc actttatttt tcatcatcac ccttgttaaa atcgcgttat gttttttaaa 1222261 aatgaggttt tgttctctga gtgagaacta gcataaccct gacttaaaaa ggaggttctg 1222321 attatggcgc atacatctgt cgcatcttta gttgttgtac ttatcgttgc atttttgaca 1222381 cccatccttt tgcatcggtt taaactcagc atcccggttg ttgttgctga aatcattatg 1222441 gggctgataa ttgggaaaag cggccttaat ttagttgtgg agggtgacac ctggctccag 1222501 acactctcta tgctcggatt tatcttttta atgtttttaa gcgggcttga aattgatttt 1222561 tcgtcgtttg agaaaggaaa gaaaaagcag ttcctgccga atggcaagga agcgccgaat 1222621 acgtttgctg cggcatctgt tattttcgtc ggtattttta ttttatcatt gctcttgtcc 1222681 tatgggttcg tcttggccgg atttatccaa aatgcatttt tgatgaccct gattatttca 1222741 acgatttcat taggcgttgt cgttccaaca ttaaaagaag aacggatcat gaattcgaat 1222801 atcgggcaga ttattttgct tgttgctgtt attgctgatt tggccacgat gattcttctt 1222861 gctgtttttt cttctttata cggagaggac agcggaaaca tgtggctcct gatgattctg 1222921 tttgcggccg gagtggtgct ttactttttc ggccgggtct tcaaacatcg ctcttttgtt 1222981 caatccatgt caaaagggac gatccagatc gggacgcgtg ccatttttac gttaatcatt 1223041 gtactcgttg ccctgtctga atcacttggg gcggaaaata ttctcggcgc tttcttagcg 1223101 ggggttcttg tttccctgct ttcgccaaac aaagaacttg ttcagcagct ggactcattc 1223161 ggttatgggt tcttaatacc gattttcttc gtgatggtcg gtgtgaagct tgatatttgg 1223221 actcttttcc aggataaaac aattttaatc atgattccgc tcctgctgct tgcgctgtta 1223281 gtcagcaaaa tcattcctgt catgtactta aagaagtggt atgataaccg aaccattttc 1223341 gcgtctggtt tcctgctgac atcaacgctt tcgctcgtga ttgctgctgc aacaatcggc 1223401 cagcagcttc acgtgatcag tacaaatatg tcaggagcgc taattttagt agccgtcatt 1223461 gcaagtattt ttacgccgat ctgttttaaa aaattataca aacgggaaga gcagccggag 1223521 gagaaaaaga cgattacgtt cattggcgcc aatcaaatga ctttgcctgt cacactcgaa 1223581 ttgccagagg aagagtatga cgtgcgtgtt gtacacgtct accaagagaa tgcggaggaa 1223641 aagctgtcag aatcagtgtt tgctgttgaa acaatttctg actatgaaca cgagacgctt 1223701 gaatcactcg gcatttttga aacggatatc ctcgttgtgg cgacaggaaa tgaagatatg 1223761 aatgcagaca ttgcattact tgcaaaagat aaaggcacag aaagagtcat tgcaagcgta 1223821 ggatcaccgg agcatgaagc agctctgaag gagcagggaa tcagcatctt ttctattctg 1223881 ctgtcgacaa aaacgctgct tcgcgcactg attgaagcgc ctggcgtcat gaagctgctc 1223941 acgaaccaag agtcttcgct gtatcaaatt aatatggaga acagtaaata tgatggtgtc 1224001 attttacggg aattcccttt aacaggtgac gtcatctttg tcaggatctt cagaggtgtg 1224061 gacagcatcg ttcctcatgg ggatacgagg ctgaaacttg gagaccgttt aattgtcacc 1224121 ggatctcggg ggtacgtaac ggatcttaag aaaacattgg aaggataaat cttgaccaaa 1224181 taaggattcg tgttaatata gaggtgcaga acaattcaat atgtattcgt ttaaccacta 1224241 ggggtgtcct tcataagggc tgagataaaa gtgtgacttt tagaccctca taacttgaac 1224301 aggttcagac ctgcgtaggg aagtggagcg gtatttgtgt tattttacta tgccaattcc 1224361 aaaccacttt tccttgcggg aaagtggttt ttttattttc agagggggaa tgatttgtga 1224421 agttttcaga agaatgccgc agtgcagccg cagaatggtg ggaggggagc tttgtccatc 1224481 cgttcgttca aggaatcggt gacggaacgc ttccgattga ccgttttaaa tactacgtac 1224541 ttcaggattc ctattattta acgcattttg caaaggtgca gtcatttggt gccgcttatg 1224601 cgaaggatct ttatacaacg gggcggatgg caagccatgc ccaaggtaca tatgaggcgg 1224661 aaatggcgct tcatcgcgag tttgccgagc tgttggaaat cagcgaggaa gagcgtaagg 1224721 cgtttaagcc gtctcctacg gcgtactctt atacatccca tatgtaccgt tcggttttga 1224781 gcgggaattt cgcagaaatc ttagcggccc tgctgccatg ctattggctc tattacgagg 1224841 ttggtgagaa attgctgcat tgtgatccgg ggcatccaat ttatcagaag tggattggca 1224901 catatggcgg tgattggttt agacaacagg tcgaggagca aatcaaccgc tttgatgagc 1224961 tggcggaaaa cagcacggag gaagtgcgtg ccaagatgaa agagaatttt gtcatctcca 1225021 gctactatga atatcaattt tggggaatgg cctatcgaaa agaaggctgg tctgacagcg 1225081 ccataaaaga ggtggaggaa tgtggagctt cacgccataa cggatgacag caagccggta 1225141 gaagagctag cgagaatcat cattacgatt cagaatgaag ttgattttat tcacattcgg 1225201 gaacgctcaa aatcggcggc ggatattttg aaactgctcg atcttatttt tgaaggcggt 1225261 atagataaac gaaaattggt gatgaacggg cgcgtggata ttgcactttt ctctactatt 1225321 caccgcgtgc agctgccaag cggcagcttt tcaccgaagc agatcagagc cagatttcca 1225381 caccttcata tcgggaggtc ggtgcattca ctggaggaag cggttcaagc agaaaaggaa 1225441 gacgcggact acgtgctgtt cggccatgtg tttgaaacgg attgcaaaaa gggtcttgaa 1225501 ggcagaggag tatctttgct gtcagatatc aaacagcgga tttccatccc ggttatagcc 1225561 atcgggggga tgacgccgga caggttaaga gacgtaaaac aagcaggggc agacggcatt 1225621 gctgttatgt caggaatttt ctcttccgct gaacctttgg aagcagccag acgatattcc 1225681 cgcaagctaa aggagatgcg ctatgaaaag gcattatgaa gcagtggtga ttggaggcgg 1225741 aattatcggt tccgcaattg cttattattt ggcaaaggaa aacaaaaaca ccgcattgtt 1225801 tgaaagcgga acaatgggcg gcagaacgac aagtgccgct gccggaatgc tgggcgccca 1225861 tgccgaatgc gaggaacgtg acgcgttttt tgatttcgct atgcacagtc agcgtctgta 1225921 caaaggtctt ggagaagagc tttatgcatt atccggtgtg gatatcaggc agcataacgg 1225981 cggtatgttt aagcttgcat tttctgaaga agatgtgctg cagctgagac agatggacga 1226041 tttggactct gtcagctggt attcaaaaga agaggtgtta gaaaaagagc cgtatgcgtc 1226101 tggtgacatc tttggtgcat cttttattca ggatgatgtg catgtggagc cttattttgt 1226161 ttgcaaggca tatgtgaaag cagcaaaaat gcttggggcg gagatttttg agcatacgcc 1226221 cgtcctgcat gtcgaacgtg acggtgaagc cctgttcatc aagaccccta gcggagacgt 1226281 atgggctaat catgttgtcg ttgccagcgg ggtgtggagc ggaatgtttt ttaaacagct 1226341 tggactgaac aatgcttttc tccctgtaaa aggggagtgc ctgtccgttt ggaatgatga 1226401 tatcccgctg acaaaaacgc tttaccatga tcactgctat atcgtaccga gaaaaagcgg 1226461 aagactggtt gtcggcgcga caatgaagcc gggggactgg agtgaaacac cggatcttgg 1226521 cggattggaa tctgttatga aaaaagcaaa aacgatgctg ccggctatac agaatatgaa 1226581 ggtggatcgt ttttgggcgg gactccgtcc gggaacaaag gatggaaaac cgtacatcgg 1226641 cagacatcct gaggacagcc gtattttatt tgcggctggc catttcagaa acgggatcct 1226701 gcttgctccc gcaacgggcg ctttgatcag tgatctcatc atgaataaag aggtcaacca 1226761 agactggctg cacgcattcc gaattgatcg caaggaggcg gttcagatat gatgctacag 1226821 ctgaacggta aagacgtgaa gtggaaaaaa gacacaggta caattcaaga cctgctggcg 1226881 tcgtatcagc ttgaaaataa aatcgttatc gtggaaagaa ataaagaaat aatcgggaaa 1226941 gaacgctatc acgaggttga gctttgtgat cgtgatgtca ttgaaattgt ccattttgta 1227001 ggaggcggat gagcatgtta acaattggcg gaaaatcatt tcaatcaaga ttgctgctgg 1227061 gcacggggaa atacccatcg tttgacattc aaaaggaagc agtagctgtt tctgagtctg 1227121 atattttaac atttgctgta aggagaatga acatttttga agcatctcag ccgaattttc 1227181 tggaacagct tgatttatcc aaatatacgc ttttgccgaa tacagcgggc gccagtactg 1227241 ctgaagaagc ggttcggatt gcaaggctgg cgaaagcttc aggcctttgt gacatgatta 1227301 aagttgaagt catcggatgc agccgttcct tgctgcctga ccctgttgag acattaaaag 1227361 cgtctgaaca gcttcttgaa gaaggcttta ttgtgctccc gtacacgtcg gatgacgttg 1227421 tgctggcgag aaagctggaa gagctcggcg ttcatgccat catgccgggt gcatctccga 1227481 ttggatcagg acaaggaatc ttaaatcctt tgaatctgtc gtttattatt gaacaggcga 1227541 aagtaccggt catcgtggat gcgggaatcg gctcgcctaa agatgcggca tacgcaatgg 1227601 agcttggagc ggatggcgta ctgctcaata cggctgtatc tggcgctgac gatcccgtga 1227661 aaatggctcg tgccatgaag ctcgcagtgg aagcagggcg cctttcttat gaggcgggcc 1227721 gaatcccgct taagcaatac ggaacggcaa gcagtccggg agaaggtctt cctgtatgac 1227781 aggcaggtat tcaaggcagg agctgtttgc tccgatcggc ccatccggcc agaaaaaatt 1227841 gaaagaagcg cgcgccgtga ttatcggcgc cggcgcgctc ggaacagcca gtgcagaaat 1227901 gctggtgaga gcgggagtcg gctctgtgaa aattgccgac agagattatg ttgaatggag 1227961 caacctccag cgccagcagc tttatacaga agatgatgtc aaaaaagaaa tgccgaaagc 1228021 agccgctgcg gagcgccgtc tccgttcgat taacagcgat gttgatgtga ccggccttgt 1228081 catggatgtg acagcagaaa atatcttcga gctgattagg gatgcatcga ttattgtgga 1228141 tgcggctgat aattttgaaa cccgcctgat cgtaaatgat gctgcggtaa aggaagggat 1228201 tccttttctt tacggtgcct gtgtagggag ctacggtctt acctttaccg tggtgccggg 1228261 ttctactcct tgcctgcatt gcttgctcga tgcacttccg attggcggag caacatgtga 1228321 cacagctggc atcatcagtc cggctgtttt gcaggtagca gtctttcagg taacagatgc 1228381 actgaaactg ctgacgggag aggagtgcga gccggtgctg cgctcctttg atttgtggaa 1228441 aaacgagcgg tcagaagtga gagcggccag tctcaaacat gacgcatgcc caagctgcgg 1228501 cacaaaggat tttccgtttt tgtcttatga aaatcaaaca aaagcggctg tattgtgcgg 1228561 caggaacacg gtgcagatca gatcatctat tacgaaagaa gcggatcttg aagcgcttgc 1228621 cggtcagctg aggcaggccg ggcttgaagt agctgcgaac ccgtatttaa tttcctgccg 1228681 ctcggatgat atgaaaatgg tgctgttccg ggacggcaga gctttgatcc atggaacaaa 1228741 tgatattgcc cgggcaaaat ccatttatca taaatggatt gggtaataaa aggagtgtag 1228801 tgtaatgagt atatataaag cattgacaat cgccggatca gattcaggcg gcggcgcagg 1228861 gatacaggct gatattaaaa cctttcaaga gcttgatgta ttcggaatgt ctgcgattac 1228921 ggcggtaacc gctcaaaata cgcttggcgt tcacggggtg catccgctga ctgtagagac 1228981 gttgagacag caaattgacg ctgttgctga ggatttgaga ccggatgcag ttaagacggg 1229041 aatgctctgg aatgccgaca tgattgaaga agtggcaaga aaaattgacg agtacggatt 1229101 caatcgtgta attgttgatc cggttatgat cgcaaagggc ggggcatcct tgctgcgtga 1229161 tgagtcagtt gccaccttaa aggagttgct cattccaaga agctacgcga ttacgccgaa 1229221 tgtcccggaa gcagaaacgc tgacaggaat gacaatcagc tcgctggatg accggaaaaa 1229281 agcagcggag cagctcgtca agatgggtgc gcagcatgtc attatcaaag gcgggcacca 1229341 gcctgaggac aatcacatta ctgaccttct ttttgatggc agcatgttta tgcaaatcac 1229401 ccatccttat atcaatacga agcatacgca tggcacaggc tgcacctttg ctgcggcttt 1229461 aacggcccaa acggctaaag gagacagcat ccatcaggca tttgaggttg cggccaactt 1229521 tgtccgtgaa gcggtggaaa atacgctcgg catcggatcg ggacacgggc cgacaaacca 1229581 tttcgctttt aaacgaaaca gcttaaatac aagccgatga gatcaccagc tgatggtgat 1229641 ctcttttgcg tttgctacgg tatgcgcttt tcatctggac aaggttatga tatgatagga 1229701 attaagatca ggtactaata ctatgtcttt attaaatata ggaggcttta tacatatgaa 1229761 tttttcactt gaaggccgta acattgttgt gatgggggta gccaacaaac gcagcatcgc 1229821 ctggggcatt gcgcgttctt tacatgaagc gggtgcacgt ttgattttca catacgctgg 1229881 tgaacgcctg gagaaatccg ttcacgagct tgccggaaca ttagaccgca acgattccat 1229941 catcctccct tgcgatgtta caaacgacgc agaaatcgaa acttgcttcg caagcattaa 1230001 ggagcaggtc ggtgtaatcc acggtatcgc gcattgtatc gcgtttgcca acaaagaaga 1230061 gcttgtcggc gagtacttaa acacaaatcg tgacggcttc cttttggctc ataacatcag 1230121 ctcatattct ctgactgctg ttgtcaaagc ggcacgtccg atgatgactg aaggcggaag 1230181 cattgtcact ttgacgtacc ttggcggaga gcttgtgatg ccaaactaca acgtcatggg 1230241 tgtagcaaaa gcttctcttg atgcaagtgt gaaatattta gctgctgact taggaaaaga 1230301 aaatatccgc gtcaacagca tttctgccgg cccgatcaga acattatctg ctaaaggcat 1230361 cagcgatttc aactctatct taaaagacat cgaagagcgt gcaccgcttc gccgcacgac 1230421 aacacctgaa gaagtgggcg atacagctgc gttcttgttc agcgatatgt cccgcgggat 1230481 tacaggtgaa aatcttcacg ttgattctgg tttccatatc actgcccgct aagcaggatc 1230541 tatatcaagc aatcccgaat agggattgct tttttatttc ttctgatttt cagctttctg 1230601 tcatatagat agaatatgac acaatcggag ggatgaagat gtctaataag aaaagaaacg 1230661 cggataaaaa accgctcatg tatattgttc agccggatta tgcagaaact acaaggtcat 1230721 ccatgcagga gattgtcatc aaaagaaagg ccgacaaacc cgctccgcca aaagctgagg 1230781 aaaagccggc ttaccatgag aagcagcagg aggaagccgt ggcacaggat gtcctgcaag 1230841 aagaccaaaa gcctgcagcc gaaccagtga gtcagcaaac acaagaggcg agagagccag 1230901 agaacataaa aagccaagag gaacagaagg cagagccgca ggccgtagaa gaaaccgttg 1230961 aacacgagcc cccgaaagca gaaaaaaagg aagagcctgc acttgaggcc cggaagcctg 1231021 agaaagaacc ggaagctgtc catagtgctg ataaagcgga ggaaaaagca ccgccggcac 1231081 gaaaagtgaa aaaaccgatg agcaagatga cgatccacga aaaaattgat tttttaacaa 1231141 agctgcctca taacatgccg agagcgcttt gtttgattga agccaatgga agaacgtaca 1231201 ggggcgtgat tgtcggaaga agaaatgatt ccgtcctgct tcgaacaacc ggaaacggag 1231261 ccccaaccga actggcaatc gatgatatta cctctttgca cccgctcggt ttttaacgaa 1231321 aaagaaaaaa gctgcccggc tgatgttgcc ggacagcttt ttttacatag agaaaagcct 1231381 gcaggcctgc aagcttttcc agcttatgat taatgatgat gtgtacgatt gattaatcga 1231441 ggatttaagc agttgattgc gcagaagcag tctaagtcaa cttcaataca gtagttcgtt 1231501 ttttcgagtc ggaacacttc acacaccgta tctttatcgg tgaagtccaa aatgtgtttg 1231561 tgttcgtcaa atgcgattaa taatgacagt gttgcacagc ttccatgcac tctttcgacc 1231621 ctgaaaaata ctgtattaaa gcaagggccg ttatcgagtt cgccgacatt tccgaaggcg 1231681 actaatggcg ttgattttga tgtaaatatt gcaaaaggca ctgtgtcgcc taacgaatgg 1231741 cttacagata aaagcttaga gtggcagccg gtcgggcagt cttcttcaac agcgttttgc 1231801 agatcttcaa tattttctac agcttcacgc acgcagcttg atgttttctg gctcatatta 1231861 tccctcctgc cttataaatt tgagactggc gaaatgatgg agagtcagct gcctcacgct 1231921 ggaagcagct gaatgatttg cacctgtaat agagtttgga aggggattcc tctttacaag 1231981 tgtttatcca ttgtgatgat gctttttatc tttgtgaggc gatgttctgt caactagctc 1232041 tggtgacagg cactgaatcg cgcagaagca tccgagatcc acttcaatgc agaaatctgt 1232101 tttttctagc ccgaagaaat ccgggtcgca agggtggcaa acacttaagg tatcgccttt 1232161 gacatcgacc gggcgtaaaa tagacagtgt tgcacagcaa tcgcataatt tttcgacgcg 1232221 gaagaaaatg gattcaaagc attgcatatc atccacaaat ccccctacgt ttccgaatgt 1232281 ggagaacaat ccgccttttt tatcaaaaac gagaaacgga attgtgtctt ttccagcaat 1232341 cgtagggttt aaaaggttgg tatagcagcc agtcggacac tgttcttcaa ctgcctcctg 1232401 ctctgctaaa atcttttcca ctgcatcgca tacacagttc tcatgccggc catgggtttt 1232461 tccgcagctc attgatttca gctccttctt tatagggtat ttgactttag tccttaacaa 1232521 catatgtacc cgtgccccac ttggtgtggg tgaacgtcta tatattcatc atatgcttgg 1232581 aaaataagaa aaagcagagc gtttttagct ctgcttttag gtcctagagg acaagagtga 1232641 taactaggat ggctacgagt gtatttgttg ctgtagaaat aagggttgcg atatcggcat 1232701 ctactgttgt gacgtttacg ccgcgggaac attcgatgag aagtttttgg cggtttactt 1232761 gtttgttagc tgtaagctgt aacaaatctt gtgcgactaa ttcggcaatt acgccgtctg 1232821 caattgatgt cagagttgcc gttacgacag cggcattaag tgctgttaca actgatgtta 1232881 cggcttgaac gtctgtagat gtaacattga tgtcacaaga atctctaata ataatcgttt 1232941 catctgaaac ttgtttgttg agatttgctt gagctagatc ttggtcgatg aaggcgttgt 1233001 cgttgccaaa aaaaccattg ccattacagc aaacgtcgca atgacatttt ctttcgtgtt 1233061 tttctttatc tttctctttg tcatctaacg gatggtcaca gtcaggatca agtgcaaccc 1233121 aagaatatgg tctgctttcc atatctattc ctccttttct tttactgtta ttaaatgagc 1233181 gagcctctta ttttgactga gtcatatatc ctgatgaaga accctatttt ttatgattgg 1233241 ctaattgtta tcgtttttcc gtctttgtct gatctgttca atgagctgct ctctgcggct 1233301 taacggtttt gtgttctttt gctcttgtgc ggctgcttct tcttttttct tcttttggtt 1233361 ttctattagc gcttgtgatt tagcttgtaa gtcttttaca agatttaaga gcatttcttt 1233421 ttcttcgtct gatacttttt tcattttgtc ttttgtgacc ccatgtttag aaaatatatt 1233481 ttggaccagc attttcgtca ttggatcaac ttctggaagc tttgcaagct cttctttgaa 1233541 tttatcgtta tctgacattt gttttcacct cgtcttttaa gtttgtgaaa agaaagggtt 1233601 aaaggacgtc aagttcacta agaatgctgt ttaacacctg aagcaagatt tgtacaaagg 1233661 ttattatctc gtcggcagac aaagtaattt tgatgttgcg gctgttgata attttaatga 1233721 tggttctttt tttgatttgg gagctatcga gaataagaat ttcacttgcc actgcgtcag 1233781 ccaaatcctc gtcggcgatg acgagctgag tcgccacgat aatcatggtt gtcacaaagg 1233841 cttgtataga aagggcagct gttatatgtg acgtgtcaat tgtgatattt tcgcaatcaa 1233901 tcacttcgat ctgctgttcg aattcgcttg ataattgctc aaatattgca gggtgcaggg 1233961 attcgacttt ttcttcaaat gacataacct tcactccttt cttatccata ctctatataa 1234021 tgcaaatggg gtgcagagcg gaataataaa aataaccaat tttctgccgg acaagataca 1234081 attcatgaag aatagggttt tggcatatat gtgaagggat catgattggc aaaggagtga 1234141 acgagtggtt ataaatgggc tgacaattgt tcttctatcg cttgcggtct ttcggctcgc 1234201 ccgcctgctg gtgtttgaca cgattatggc gccgcttcgc agtctgtttc atgaagagaa 1234261 ggaagaaaag gatgcggacg ggaacattga aacctatatc gtgattaagg gaaccggtgt 1234321 cagggcgttt attggtgaat tgctgagctg ctattggtgc acaggcgtgt ggtgtgccgg 1234381 ctttttgatt ttatgccagg cggtgatccc gcaagcggcg cagtggctga ttttactttt 1234441 ggcgatcgcc ggccttgccg gcattataga aacgctcgta tcaaaatggc tgcaagaata 1234501 aggcgttacc accagcaact ttctgtcaga atacgcataa agtagcatat atgacataag 1234561 gaaaggaagg ggacaaaaat gaatcagcat cataaacctt cccaaaaatc tccatataca 1234621 gattcatcgt atcaatcaaa aaagataaaa aagaaaggct gcgggtgcgg aaataaaaag 1234681 aaaaagcctc aatagcctgg caaagaaacc ggagaactcc ggttttttgt ttttttaacg 1234741 aggcggtctc gctcagcata tatcataagc ggggggataa aagtgaatga gtttgaaaaa 1234801 tggatagaag gaagatatga accacatgaa caaaagcaaa aagagcatga agacacgatg 1234861 ggcagtatca gaaaagactt ggatgcattt gataaagccg gtctggaatt tgaagatgag 1234921 attgaagagc tggctgaaaa aacggaggcc ttacttaaaa aacatcaagc tcaatatgat 1234981 caatcgtaaa tccgcaaacg ccctatgcga atatccaagc cgatcccagc agctcacata 1235041 gtgtatagag agtaaaggag gtgcttatct atgggctttg gatacggatt cggcggcggc 1235101 tacggcggcg gctgttatgg cggttatgct ggcggttacg gcggcggcta tggttcaaca 1235161 tttgttttgt tggtcgtatt attcattctc ctcatcatcg taggtgcatc tttcttttaa 1235221 gatgtattga ggaagtacgg gttataaccc gtacttcctt gccttgtgtt tatttttaaa 1235281 aatgttggaa aagcacattg tattatgtgc attcatacaa taccgtatta ctccgccaaa 1235341 aggaggcgca ttatggataa tcaatttttt aagaacatcg aaaagaaaac aggtgtgaag 1235401 atgcaggatg taatgaatct tgccggatca ctccaaaacg ctaattttaa agatgaaaat 1235461 acagtgcgca gtgtgattaa ccgcgtagcg cagatggcaa acagacgcgt gccaaaagaa 1235521 ttagaagata aaattgtgga atctattaca agcggaaaag aaaagcttga ttttggcacg 1235581 atttctaaaa tgatggataa taaataagtg gatggcctgg ctgactcact gcagcgggcc 1235641 tttttttaca gtaaaaaccc ggcagtaatc tgccgggctg ttaatgatgc aagggctgtc 1235701 ttgctttctg tagcagggga tacaaaaatc ttgagcggtt ggctgttttg ccgcgcctgt 1235761 tagcagggca agacaaatat aaatgctgtt tcgcccgggt catggctaca tataaaaggc 1235821 gtctttcctc ctcaagagcg gcctcgtctc cttttcttgc cgtttctaat gagaaatcgt 1235881 gcggaatcga gccatctaca gtgcctaaca cgtagactgt tttgaattca aggccttttg 1235941 accggtgaat ggtcatcagc tgaacgccat gttcatccgt tctgtttttc tcagcggccc 1236001 tcatatggtc tacgtgggca agaaagtcag gaatcgtttt gaacttcttg gcgacaacct 1236061 tgatgtcgcg caggtcatca gagccttttt ccagcttgtt gccctcattg ccccgctttt 1236121 ttaaatactc ggagaagccc atttttcctt ctgcaaaggt gatggcttct acgggtttca 1236181 ttgtgcggag gcttgcaaaa aacggtacga ttttcttgat tttgtccagc tggaatggct 1236241 tcagatcagg caatttggcc agcgctttga tcatggtaca gtcctctgta atcgagagcg 1236301 ccttcagcgt attcaaagcg gactgtttta aaaacaaggc gggaagcaag tgtttaatcg 1236361 cctcggtgtc atcctcattt tggctggcgt acaagtaggc gagaatctgg cggacgatcc 1236421 gtctgctgta aaacgattgg acgccgcggt cagctgtata cggaattgac gattgatgaa 1236481 gcctttcata tatagcacgg cctccgctgt ttgtgcggta aagaaccgca aagtcttctg 1236541 gactggctcc attttgaatt ttttctttga tatcggaaac gaccattgtg gcttcttcct 1236601 cttcatcata aggataaaac agcacaggga cctgaatgtc atcgcgggcc gcttcaagcg 1236661 ttttggcata tctgtttttg ttctttttca caacgatatc agcactagag acgatcgggt 1236721 gcgtagacct gtagttcgca gttaaataga tcgtcttcgc tcccggataa tccttttgaa 1236781 aatcaagaat gaaagacgga ttgcttccgc gaaacgcgta gatggactgg tcatcgtctc 1236841 cgacacagca caggttttgc tccgggctgg cgagcatttg catgattttg tattgaaccg 1236901 gattaatgtc ctgaaactca tcaattaaga tatacgtaaa ccgagattga tattgttcca 1236961 gaaggtcagg ccgctcgata aacaattcat agcaggctga agccatgtca tcaaaatcaa 1237021 attggctgtg ttcttttttc tggcgttcat aatgttcata taaacgataa acttgttttt 1237081 cccactcatc ttttagaggg atgcgttcat ttgggacata agtgtttttc caaaaaccga 1237141 tctgctgcag ggcttggtca actggggatt ctttctcatc gatgccttct tcatagagtg 1237201 cttttttgat atattgttcc cgctgccact ccattttcag cagatgctca ccgttccatt 1237261 tagcagaatt agagtgatac aagatcttat aaaacagact gtggaatgtt cctgtcacaa 1237321 ttcttctgac ttttgccggc tgtaatccgt actggttcgc catacgctct ttcatttcag 1237381 cgacagcttt tgttgtaaag gtgacaagca gcatattttc aggcggtatg cctaagtgtt 1237441 cgatcatgtg ggcggcacgg gctgtcagta cccgtgtttt tccgctcccc gcacctgcaa 1237501 gcacgaggag cgggccctct gtttccgtga cagctttcag ctgatccgtg tttaaaccga 1237561 cagacggaaa aaggctcgta tcgggttcta ttgtttttgg cacaaatggt gttcctggtt 1237621 taatgcttct aggacggtgc cattctgtaa cagctgggga cgggtcagcg gcgatcgctt 1237681 ttcccttggg taaacgaatg acaccagatt cctgatcatc ttcttttttc ccctctttag 1237741 agggcttcgg ttcgcacgcc tcctcacatg ccggaaaatc gcctggctgg cgatggataa 1237801 actctggcgg atcggcgatg ttaagccgta acaaaacggg ctttccgcaa tgagaacaaa 1237861 ataaatgtcc ttttattccc tcttcaaaga ggaattgata atgttctctc gaatatgtat 1237921 gtaaatgtat gattctatca ttcagtcggg cgcatttcaa aaaggggtcc tcccaatcaa 1237981 aaggtgttca ttacagacaa tgactatcat atcaaaagaa atgtgtttca aaaagtaagt 1238041 ttaagggaaa agagacagca gaggggtggg tattgtatga tatatgcagg tcaaattcag 1238101 aaccagcaat acgctcaata tgctaataga acgattggac ataagcagga ttatgccgga 1238161 accgaaaaaa tcagctatgt cccgtttcag cgggtataca aagaactgga aaagcagcag 1238221 gagaatcaaa cggcagctga aagaaaagta aacgagatga aacgtaagcg ctctctttat 1238281 aagagattgc gagaaaaagg aatggggaca tatattaatc gatatgtata aaaaaccgtt 1238341 cataccagag aacggttttt ttatatgcag taaaaatccg gatctcaaaa gatccggatg 1238401 cgttcagtcc ttcatcattt gtaagtgcgg aatgccggca tcgaggaatt ctttttcaga 1238461 aagcacgcga tacccgtgtt tcttgtaaaa cggcacagcc tgtgtttgcg cgtttaaaat 1238521 gaaaccggaa gcgcctccgt ctgccgcggc tttttcgagc gctttcataa tgatgccgcc 1238581 gacaccggct gagcggtggc ttttcagtac gcaaatccgc tctaacttgc cgtagccgtc 1238641 cttcatgcgc catcttccgg caccgacagg cttttcaccg tcatacacga cgatatgctc 1238701 tgactcattt tcaagttcgt caatttcttc ttcagcaggc acgttttgtt ctttgacaaa 1238761 gacttcttct cttacataga atgcatcttt cagttgttct tcattttttg cgataactgc 1238821 tttcaaacat tattctcctc tgcctagcaa gaaggtttca tatactgtcc acgatccgtt 1238881 ttccaactgg tagagcaagt ggaaacggtc aacgatttct tcatgcgaca cttcctgcat 1238941 ttttaattgt cccagcacat ctgaatgctc atcgtcggaa agattttggc cgaccgtcac 1239001 atgcggaacg aaattatatt cctgttctcc tgccaacaca ccggtgtata gcttttcatt 1239061 gagtgttttt aactcttccg tcggttctgc tttgatgtaa atgacattat tgacaggcgc 1239121 aaatgagctg tattttgtca ttttgagaac gagtgggtgg gactcttttg cgatgtttct 1239181 taaatgtgat acgagctgat ccgctttctc ctccgcgcat tcaaaggatg ctctcagcgt 1239241 caaatgaggc gggattagag agtagcttgg gtcatagcgc tttctgtaag agtttgcaag 1239301 gtcttggagc ttttttgatg gaaataaaac gattccgtat ttcatattat gtccctcctg 1239361 gaaataaagt atgatagagt gttaaagcat ttttttcagc gccggggtga tgagcggctg 1239421 ccagtatgtc catttgtggt ctccgtcaaa tggctcgaaa tcataatcgg aaagcttttt 1239481 ctccagcagc tgtttcagct cccggttcgg ttctgtaaag tccagaatgt tcccgtctgt 1239541 cgtgtggacg tcagtttctt ttgttccgat ttggtgataa atagagaggt gtttgatatc 1239601 gtctgactgt tttacggctt ctagtacgtg tttgtcaaca tagggagact gcatgatgat 1239661 gttgccaaac atattcggat aatcaagcgc tgtcataagt gacacggttg ctccgagcga 1239721 atcaccgatc agcgttcggc cgtaaccgat ctgataggtt ggatactcat catctgcaaa 1239781 aggaacgagc tcatgggcga tgaaccgttt ataagccgaa aattttgaac cctccggatg 1239841 ataagtgttt ctgcgctctt ttacatcctt atagggaaca ccgataataa tgctccggtc 1239901 tatttcgcgt ttcgacagca attcctcaac ctgtctgccg attctcccca gcctgaaata 1239961 atcgtggccg tcctgcgcga taatgacatg gtatttataa agcggggagt agttggacgg 1240021 cagataaaca agcaaggtca tttcctcgtt aagctctttt gaaaagaatt tcttttcttg 1240081 cactgtgccg tttttcggtg ccataaaaac attcctccag gacatcacta tactttcttg 1240141 cattttcaat tattgtacca tgaattatta gaaatttctc tctttaaacg gttcggcaca 1240201 cgaagaaaaa agtgttgaaa taaactgtga attgcgctaa tataaaacaa tcagaaaatt 1240261 gaaatcgata tttcttatcg tgagaggtgg agggactggc ccttagaaac ctcagcaacc 1240321 ggcttgtttt gcatttgcaa agcgccaagg tgctaaatcc agcaagcgtt ttttatgctt 1240381 ggaagataag aagaagcgtt aaaccccttc ttcttatgaa gaaggggttt ttattttgaa 1240441 aagggaaggt gtcagctata tgtcacagca cgttgaaacg aaattagctc aaattgggaa 1240501 ccgtagcgat gaagtcacgg gaacagtgag tgctcctatc tatttatcaa cagcataccg 1240561 ccacagaggg atcggagaat ctaccggatt tgattatgtc cgcacaaaaa atccgacacg 1240621 ccagcttgtt gaggacgcga tcgctaactt agaaaacggc gcgagagggc ttgcctttag 1240681 ttcgggaatg gctgctatcc aaacgattat ggcgctgttt aaaagcggag atgaactgat 1240741 cgtttcatcg gacctatatg gcggcacgta ccgtttattt gaaaatgaat ggaaaaaata 1240801 cggattgact tttcattatg atgatttcag cgatgaggac tgtttacgct ctaagattac 1240861 gccgaataca aaagcggtgt ttgtggaaac gccgacaaac cccctcatgc aggaggcgga 1240921 cattgaacat attgcccgga ttacaaagga gcacggtctt ctgctgatcg tagataatac 1240981 attttataca ccggtcttgc agcggccgct tgagctggga gctgacattg tcattcacag 1241041 cgcaaccaag tatttaggcg ggcataacga tctgcttgct ggacttgtcg tggtgaagga 1241101 tgagcggctc ggagaggaaa tgtttcagca tcaaaatgca atcggcgccg tcctgccgcc 1241161 atttgattcg tggcttctga tgagaggaat gaagacgctg agcctcagaa tgcgccagca 1241221 tcaggcaaac gcgcaggagc ttgcggcgtt tttagaagag caggaagaaa tttcggatgt 1241281 gctgtatccc ggaaaaggcg gcatgctgtc cttccgtctg caaaaagaag aatgggtcaa 1241341 tccgttttta aaagcactga agaccatttg ttttgcagaa agcctcggcg gggtggaaag 1241401 ctttattaca taccctgcga cccagacgca catggatatt cctgaagaga tccgcatcgc 1241461 aaacggggtg tgcaatcggt tgctgcgctt ttctgtcggt attgaacatg cggaagattt 1241521 aaaagaggat ctaaaacagg cattatgtca ggtcaaagag ggagctgttt catttgagta 1241581 aacacaattg gacgctggaa acccagctcg tgcacaatcc atttaaaaca gacggcggaa 1241641 ccggggcagt cagtgtaccg attcagcacg cctcgacttt tcaccaatct tcatttgaag 1241701 agttcggggc atatgattac agccgctctg gcacgccgac aagaacagct ctcgaagaaa 1241761 caattgccgc actggaaggc ggaacaagag gatttgcttt cagttcaggc atggctgcca 1241821 tctcaacagc atttttactg ctgtcacagg gtgatcacgt tcttgtgaca gaagatgtat 1241881 acggcggaac cttccgtatg gtgacagagg tgctgacccg gtttggcatt gagcatacgt 1241941 ttgtcgacat gacggatcgt aatgaagtgg cgcggagcat caagccgaac acaaaggtca 1242001 tttatatgga gacgccatca aatccgacac ttgggattac ggatattaaa gcagttgttc 1242061 agcttgcaaa agaaaacggc tgcctgacct ttctggacaa tacattcatg acgccggcac 1242121 tgcagcgtcc gcttgatctc ggcgtggata ttgtacttca cagcgcgaca aaattcttaa 1242181 gcggacacag cgatgtgctc tcaggtttgg ctgctgtcaa agatgaagag cttgggaagc 1242241 agctgtataa gctacaaaac gcgttcggcg ccgtccttgg cgtgcaagat tgctggcttg 1242301 tcctgcgcgg attaaaaaca ttgcaggtcc gtttagagaa agcgagtcaa acagctcagc 1242361 ggcttgcgga atttttccag aagcacccgg cggtcaagcg cgtgtattat ccgggactgg 1242421 ctgatcatcc cggcgctgaa acccataaaa gccagtcaac gggagcgggc gccgtgctat 1242481 cttttgagct tgaaagcaaa gaggccgtta agaagttagt cgagaatgtg tcactcccag 1242541 tcttcgctgt cagccttggc gccgtggaat cgattttgtc ctatccggca acgatgtctc 1242601 atgcggcaat gcctaaggaa gagcgtgaaa aacgcggtat cactgatggc ctgctccgtc 1242661 tgagtgtcgg cgtcgaacat gcagacgatt tagaacacga tttcgaacaa gcgctgaaag 1242721 aaattgctcc agtttcggtt cgttaaaaaa gaagccgggg atagtccggc ttcttttatt 1242781 attgttcgtc atcaggattc agaatcgcga ggacttgatg atcctcccaa acgccattaa 1242841 tttttacatt ttttcgggcg atgccttctt tatgaaatcc cgctttttct aaaacacgca 1242901 tggacccgag attacggggc atcacaccgg cttcaatccg atgcagtttc aattcgtgga 1242961 acgcataatc aacaaccaat ctgactgcct ctgtcataat gccctttcca ttatgggctt 1243021 tgtctaaaaa atacccgatg aacgcagttt gcagcgcgcc acggatgatt tgaaagagcg 1243081 aaaccgtccc gattaatcta tcgtctgacg ctgtaaagat gccaaaatga tattcttcat 1243141 ctttctcaag tctttcctga tactcggtta ttcgttttct ttgcccctca accgtatagt 1243201 aatcgtctgc gcgtatcata gaaaactgtt cgaaaaaatc tcgattttcg ctttgcagcc 1243261 ccagattttc ttcggcatcc gttacttcta aaggtctaac ataaatggtt tttcctttta 1243321 acatatagtg atctctccgt tctcatgtca gcattcctct tacattattc tcagggaaat 1243381 gcaaatatcc tttttataag aaggaagaaa accaatttcc cataaaagtg ccaacatagt 1243441 tgccgattaa gtagccgagc gtaccgacaa gcatgatcgg ggcgacaagc tcccgccatc 1243501 ccttggcaat tgccatcgca gccgcagtcg tcggtccccc gacagtagcg ttgacggcga 1243561 gcagaatttc ttcaagccgc acacggaaca attttccggc agctaaggaa accgctaaat 1243621 tgctaatcgc aatgataaac acgaataata gaataagagg cgcattcgtg acgattaagc 1243681 ggagatctgc aggaatgccg atcaccacaa aaaacaaata aatcaaaaag gttccaagct 1243741 cctgagatcc attgagcctt tcaaaaaaac gcgggaaaag aaaaatgata agaacagtta 1243801 aagacgtaag aaccaggtac tgatcgccaa gcgtaccggt cagcagggga tgagaaaaaa 1243861 tgcttttaaa ataaccggaa accttcatac taaccgcaac aagcgcgaaa gcggcaccgg 1243921 cattaaaagc gatatccttt aaggaaatat ccttccgttt ccaatagctt tcagcactgt 1243981 ttccgctgtt tccatcggct tttaccttct cttcaaacgg catggcataa tgccgctgaa 1244041 accatttgag tgcaggaatg ctgattaaaa taaaaaacaa aagcgccatc ataaaattat 1244101 cagccacaac ggtagccgac acatattcac caggcgtctc aaattttgcc gccatcgccg 1244161 caaagttgac cccgccgccg atataagagg cgctgatcat cccaccgatt ttatctaagt 1244221 aaggaatatg ctgtttgagt agaaaaaaag ccaggatact gccaagcact gttccaacgg 1244281 agctaatcag aaaaataaac agcaaacgcc tgctttcctt aaaaatttgc ctaacattga 1244341 tctgaaacaa taaaagtggt atcgccagcg gtaccacata agaccacaca gtgtcataca 1244401 cgggcgactc aacaggaagc actcctacat ttgtaaacac catagcacct gcaagggcga 1244461 taatagcgcc cgacacagca gacgcccact taaagcgctg ctccagcccg atgctcactg 1244521 ccgcccacac cgcaataaac ccccataata cccatacatc atcagaagaa atcaaagaat 1244581 gcaaaacccc atcacctcta ttgttagaaa attaagacat attataatag ccggggaacg 1244641 gaacagcaag tccaaaaaaa gtttttctaa aaaagcagtt gacgaataga aggtaaggtt 1244701 atataataga acttgtcaga aagataacaa catacccagc aacacataca tatcatgatt 1244761 ccgtagctca gctgggagag cgctaccttg acagggtaga ggtcgctggt tcgagcccag 1244821 tcggaatcat agcttaaacc cttgcgcagc aagggttttt tactttgcgt taataaagcc 1244881 ggttcgtcaa attcgtgagt tgttggcgaa ctgttggcga aattcattga ccgcagtcca 1244941 aaaactacct ccaaacttac ttgattagtt caatagtaac aaacggaaga tcggatttct 1245001 gttaaatctt cattgagaat agccagtcca agaccgtcac ttcagccatg catcttttaa 1245061 atgaaatttt gtactgaaaa catcaattgt atttttaaat tctgctctag aatcagcccc 1245121 tttataataa tcttgataaa ttgcttgggg tgatactgat tcgtgatttg tgctatggtt 1245181 tgcaaggctt gtagcaaaag caggagcaac agtaacgagt aaagcaaggg ataatgcaaa 1245241 accagttaaa gctttttcaa tttcatttta agcacttctt tttttaaaat acaactttat 1245301 tattaaatgg aatacaaaaa catccaaggt gtttttttgt tagtaagttg agttaggggg 1245361 attggatggc acttagaata ttgtttctgc tgatgggatg ttgattctgg atatatttcc 1245421 aacacgatta caggccggac atgaaagcga accttgcttt gatcggggca atcatttcat 1245481 ttacggctgc ggtttacttt aaagatattg atgtattgag agaagaggga aaacaaatga 1245541 acggaatttc tgagcgttgg aacacgttta aattacaaaa atcccctgaa ccactctaga 1245601 tcaggggatt gctttcccaa cagcttatta agtagcggaa ggcatgatca acgatttagt 1245661 atcaatttat taattgcgaa tactagaaac ataccgtttt ccgccttcct tagaagtaac 1245721 atattctcga ggaacattaa gtctattggt agaatgataa cttacataaa gtttcatatt 1245781 tgctcggctc gttacgatag ccgtatgatc catccaacca tcagcatagc gaagacctat 1245841 tttattatgg taatcatagt gatatacatc tccaagcttt acatttgaat atgtatcaga 1245901 aacagtcttc atttttattc cgccagcttt taaaatgtat gatctaaagg ctcctgcatt 1245961 aacccaagca tctgtatagg gtttccattc tttaaagtac ggcattcttc cagctcttaa 1246021 tgcttgggaa acaaagttag tacaatcttt gtctttataa tatttatagt ttttatttgg 1246081 ttttaaggca tatttttctg catatttcat tgcagcgtaa ccactatatc ctttaacaga 1246141 tgttgcagtc acagttagtt gattagagtt agcagcattg aagttcatac ttactggttt 1246201 atcttcactt ttcacttctt ctttatcatc atttttcact tcttgcttat atttttttaa 1246261 aaattcatct aatttaacat ccgaagaata ttcttcatca ttttcatatt gtagagttga 1246321 agaagaatta tttaattgtg ttacatttag ttgcttagaa gaattactca atggtattac 1246381 atttagttga ttagaagaat ttttaacttg agagaaactt agattagaag tatttgttga 1246441 ttgagaactt tgtttattag aagttgtttt gggaatttca agtttaatat tatcgcccag 1246501 agatgttgtt actttttcaa caccaaaaac aaagtttcga gtaatataag cttcaacaat 1246561 tagcttattg tttttttcag aagtcttaac atcgtctata tcgtatgtaa actcgtggaa 1246621 tttttgtttg tccactttac ttaacgcaga atacagtaag actccttcgt cggaatcagt 1246681 caatttagac tctttaggat gcgctaaagg agtgttgtgt tcaaaatcat atttttgttg 1246741 ttctaacata tccttaactt tttcgtaacc aatctcgttg gtaattgaaa cattttcttt 1246801 agtctcttta ttagtagtgg ctgcaaaaac ttcatttgtt gacactaatg gtgacaatga 1246861 tagacataaa actagtgaag caagtaattc ttttttcata cgaaacctcc aataaaatct 1246921 aaatataagt aatatttatc atttacacca attgaaatat ggcataaaat acatgtaata 1246981 atataacata aaaataaata cataaaaagg tatcggagga aaaaatgaaa aagaaaacta 1247041 aaattatact ttctctcttg gcagcactta ttgttatatt gatagtactt ccagttctat 1247101 ctcctgttgt ctttacagct tcttcggaaa aaggagcaat cagacacgaa atttataaaa 1247161 gaggatatcc ctaccaaagc tactttgcag ttctccagaa aagagaagga gacaatgaat 1247221 ctgggaatct ttattatgta aattggctag attggaaaga tgaaacaggg caaactcctc 1247281 acttatgcta ttcgaaaaaa tcatcagatg gtgaatacga agtaagttgt ggcacagggc 1247341 cgtaaaaata aattttaaaa ttgaataagt ccaagacgga aagcctgcgg acactgatcg 1247401 ttttacagag aaatttgtgc ttcgatcggt gtccgttttt tttcgcaact aaccagatgt 1247461 ctatcgcgat tactagctat gaaaggagta attagacatg aaacagtcca aaaagaaacc 1247521 atcacagaag caacatgagc gcttagatcg tttctggcaa caaatgatga acactaacat 1247581 gcaaacactc agacgtggca aaggcggcgc ttataaacgc agaaagtaaa aagggagttt 1247641 gaggatgatg aaaaacggat tcgcttataa aaacggaaag cttgtgaata tcttttgcgg 1247701 caaagaagag ctctataacg agttgaaagc cttcttggtc aaaaccttca gtatcaacgt 1247761 gaaagaggta tcgaggccct caatatatcg cagaacaaaa agcaaacaac tggaatgaca 1247821 cttactctat ttaactatca ggagggaaag cactatgaca gatcaaatga ttgcatggga 1247881 gattgaggaa tggattcgtg attataaatt catgctgcgg gagatcaaaa ggctcaaccg 1247941 tgtattaaac aaagtggatt ttattagcac aaagctcact gcaacatacg gggaggaagc 1248001 gggcatgcca aggggatcag caggcgtcag tcaggcagaa ttgcggcaga tggaccgaag 1248061 agaaaggcgg cttcacaaat atgaatctat tgtgcattac ctggacaatg caatggaaca 1248121 cattgaagaa gaaaagcacc gaatcgttta cgattgcatg atggaaggca tgagctacac 1248181 tgctattgca aaccaccttg attgctcccg ggataccatc agaaagatca aaacagccat 1248241 aatcggcaac atcgtcaata aagtcaaaga agccaacttt ctgcaatatt tgaattcgtt 1248301 taaatcggcg gtgtaaaatg gggggcagga tcggcgcggc ggattattcc tgcgtcacca 1248361 ccaatttcat acaatgagta aaacctccca gtggtaagcg aggatcaact caactgggag 1248421 gtcttacata gtgaatcggt gataaaacag cagcagtatt gcgtacatgt taatatcccc 1248481 gacaaaatat gtttttttca acagattcgt tcgacaaatt ttgcaaattg ttaatcgata 1248541 acttttcatt cccgatatta aaaatgggag tgaattgtaa aatgaaaaaa cagaaaaata 1248601 ataaaaagaa gaatattgaa aagcgaaata ttgaaaagcg aaatattgaa gagaagaata 1248661 atgaggactt agaagaactg gaaaatgcga tttatactta tcacaaaaag gagctacttg 1248721 ctttctttct tgaaaaaact cgaattggtc atgataagga agaatacaaa aggttccaat 1248781 ctcttcttta taagttggat attgaatgtt tagaatttgc tatatcgaga ttttctcata 1248841 tagatattat ccatgatcat tcaaaatatg ttccagcctt tatcccttta tttgcagcat 1248901 atctcaccat gttctttaat ttttatgaaa aacattgggg agctttatct tttgctgctg 1248961 gtacaattgc tgctattgtt tggataattg cagtagaaag aaaacataga aatcaagcaa 1249021 tttctattat gaaaatattt gaacaagtca aagagagaaa agtgaaagac agatctaaag 1249081 actgaaagga gaaaatatga ataaggataa attaaggtat gcaatcttaa aagaaatttt 1249141 tgaaggtaat acccctttgt cagaaaacga tattggagtt actgaagatc aatttgatga 1249201 tgctgtgaac tttttaaaac gcgaagggta tatcattggg gtccattatt cagatgatag 1249261 acctcattta tacaaattag gacctgaact gacagagaaa ggtgaaaact acttgaaaga 1249321 gaatggaaca tggtctaagg cctataagac cattaaagag attaaagatt ggattaaata 1249381 ataagagcat cctgcggggt gctttttttg ttccctgtaa actgcttccg gtaagtctca 1249441 ggatagacaa ttggcggtta acggcttgag cacggtggtg gtttagaggg aatatctttt 1249501 ccaaaacaac acgaatcaga agggggcggc ggtgaatgta gatggccgaa aagcacattc 1249561 aggcgtataa ggattacgtc aaaggcatga aatacaagga ccttgccgag aaatacgggg 1249621 tgtcagtgaa caccattaaa tcgtggaagc agcggcatgg ttgggaaagg aaaaagggtg 1249681 cacccattga aaaaagtgtg cacacaaaaa aaggcgggca accgggcaac aaaaatgcat 1249741 tagggaacaa tggcggcgca ccacagaaga atcaaaatgc tgtgactcac ggctttttct 1249801 ctaaattctt gccagaagag acgcttgaaa tcatggaaga gattcaggag cgttcgccag 1249861 ctgatatgat atgggatcag atacagattc aatatgcggc cattcttcgg gcgcaaaaga 1249921 tcatgttcgt ttctgataag gaagaaatga tcaaagagct gaaaaagaaa aggtccctca 1249981 tatctgaggt cagcgaaatt gaagatgggc ttgtcattag ttttagtacg tggtttcgct 1250041 acagacttta cagtgaaaca aacacctaac acatttcaca ttgcttcaga ttgccttcaa 1250101 acttgataat ataacttcta aaccttccta taaaatgaag gttttttatt tgatttcaat 1250161 ttttaaatcc tttacataca gcgattgatt aactcgagca atcaatgtcg cagttatatt 1250221 tatttttcaa gaaaatgtta taatgaaaag ccataaaatg atgggagggg gaatttcgat 1250281 gcattacata acggcatgtt taaaaatcat cagtgataaa gaccttaatg agataatgaa 1250341 ggaattcaaa aaacttgagg aagaaacgaa caaagaagag ggttgtatta cattccatgc 1250401 ttatccgctt gagccatcag aacgtaaaat aatgctttgg gagatttggg aaaacgaaga 1250461 agctgtgaaa atccatttca caaaaaaaca cacaatagac gttcaaaaac aagaattaac 1250521 ggaagtagaa tggttaatga aaagcaatgt gaatgattga aaggctcttt aaaaagagac 1250581 attcaatgac ttagtatcag ccacttgtga ctaagtagta aattgttgtc caactcttat 1250641 tttttctatt taatattttt tgagacgaaa atgttttttt aagctgattt taaaatgtat 1250701 tcaaagtcag ctctgtttga tttaatggat tatattattt ggatagcttg ttaccatcat 1250761 aatggagata ctccttataa attggaggtt aaaataatga gtcattctca agaaaaaatt 1250821 gcactaatta caggagcaag cagtcaaggg gatattggta cggctatttg tcgtaagtta 1250881 gcctcacagg gtatacatat cttctttact cactggaatt ctgatacggc ctggatagaa 1250941 gaatttcaac aagaaatttt acgtatgggt gtccgctgtg aggcaatgaa aattgattta 1251001 tcagatgcac atgctgcatt cacaatacat gaaaaaattt cagataaatt aggatatcct 1251061 tccatcctta ttaataatgc agctcattcc gcaagtgata attatgtatc gttagatgct 1251121 aaatcacttg atgagcatta tgcggttaat atgagatcga attttcttct ttgtgttgaa 1251181 ttcgcccgtc ggtttaaaaa atctaattta atatcaggaa gaatcatcaa tatgacatca 1251241 gggcaggatt taggtccttt gcctggggag ttagcgtatg cagcaactaa aggagctatt 1251301 tctgcattta ctaggtcgtt atcacaagaa cttgcaccat tgggcatcac tgttaacgcc 1251361 gtaaacccag gtccaacaga ttctacatgg atgacagatg aaataagaaa ttttctttca 1251421 cctaaatttc caatggggcg tattggcaca ccagatgatg cagcacgaat gattgccttt 1251481 cttgcaagtg atgaggctga atggataact ggacaaatta ttcattcaga aggtggattt 1251541 attcggggct aagctaatga aacacggtat acaccaatgt atgatgtatt cccaaaacta 1251601 aatctaaact tgaagcgaaa ataaggtccc ttctcttttt agagggggac cttattttat 1251661 tcatgcatgt tttgcatcca gaaaatctgg cggataaaga ttaataaacc gttacatata 1251721 cttttccgaa tactgcagta cctttaaaca aagtaatcgt ggctttccct tttgatttag 1251781 ccgtcactaa accattttga tcgacttcag caactttttg gttatcagtc caataacgag 1251841 tagctgaatt atttttaaca gaataggttt ctccaacttt tagaggtaaa ttatagtctt 1251901 gaatcttgat aacatgtgta ggtgaaatag aaatgttctt tacttcagta ggtgtggagt 1251961 ttatttcatg agctgaagct accccgctga ccgacagagc taacgcagaa atcgataaag 1252021 cagaaacaac cgtttttttg aaattcattt tgaaacactc ctttaaagtt ttttgtcttg 1252081 cactataaca attcaataaa agtaattatt ttccttgtaa ataaatgtta ataatatgtg 1252141 aacgatcaat tgatttgagc taagaatatt gtgtgccctg cacagagttt gtatttatga 1252201 tggaaaattg ctgagagaga atggccatcc ttaaaatgtt aatagcacac atttgatggg 1252261 tattagtttg ttgagcgtgt ggaaattttg ttacctgcac tttatccccg aagataccaa 1252321 atcacttttc ttcatcatgt tcttactttc gtactcatac attagaaaat cttcgttcta 1252381 aataggtgaa gaattggagt atttttatga atttctgctg aatatacatt acatagcaaa 1252441 ctcaaagagt ataaaaatcg cttttttccg gaagcttcgg taaaaaacga aacttttgtc 1252501 tctatgattt tgttttataa tgtaaacggt ttcttatata gtatacttat actatcaatt 1252561 tgctcaagta gatactgaca ggaaggatag aaaaacagat ggaatacata aatacaagac 1252621 aaaaagagat tttgtatctg ttgttatctg aacctgatga ctatttagtt gtgcaagatt 1252681 tcgcagatag ggtacagtgt tctgaaaaaa caatccggaa tgatttgaaa gtgatcgagg 1252741 attatctcaa tgagcattct catgcacagc ttattcgaaa accagggttg ggcgtttatt 1252801 tacatataga agaacaggaa aggacctggc taagccaaca attacatact gaacattttt 1252861 cttctaggca gcggagcgat aaggaaagaa tgctgcacat tgcttatgac ttattaatga 1252921 atccgaagcc tgtttccgca aaagacattg ccgctcggca ttttgtcaat cgatcttcca 1252981 ttaaaaagga tttatacgca gtagaagagt ggctgaagcg ttttgatctc acactggttt 1253041 ctaggcagcg gcttggatta aaggttgaag ggaacgaaag aaataaaaga aaggcattgg 1253101 caagaatatc tgatttgatt cacaatacag cgtttaccag ccaatttatt aaaagtaagt 1253161 ttttacatta tgaagtagac tttgtgacga aagaaatcaa atcactacaa aaaaagcatt 1253221 ccctctattt cacagacgaa acgtttgaaa gtttgttgct gcatacattg ttaatggtcc 1253281 gccgcatcaa aatgaagcag ccgatttcat tgtccccaaa agaaatggcg gcagtaaaaa 1253341 agaagaaaga atatcaatgg acatttgctt gtttacagcg gcttgaaccg gtttttgcaa 1253401 ttcgcttccc tgaagaagaa gccgtgtact taacattaca tatattgggc ggtaaggttc 1253461 gttatccatt gcagacagaa gagaaccttg aaaatgctgt gcttcctaag gttgtagggc 1253521 atttaatcaa tcgtgtttca gagctgaaaa tgatggattt tcacaaggat caggatttga 1253581 tcaatggttt gaacattcat ctcaatactg tgctacaacg gctgagctac gatctttctg 1253641 tagcaaatcc tatgctcaat gacatcaaaa agatgtaccc ttatttgttc cacctcatca 1253701 ttgatgtttt ggaagacatc aatcaaactt ttgatcttca tattcctgag gaagaggcag 1253761 catatttgac attgcatttt caggcagcga tcgaacggat gcagggcagc agcgagacac 1253821 ataaaaaggc ggttatcgtc tgccacatgg ggattgggat gtcacaattg ctgcggacaa 1253881 aaattgaacg gaaatatcac caaatcgctg taatggcttg tattgcaaag gccgatttaa 1253941 aggattatat caaaaagcat gaggatattg atcttgtcat atccaccatt gcgctggaga 1254001 atataacggt tccccatatt gttgtgtctc cgcttttaga gcctggcgaa gagaagaaat 1254061 taagtgcgtt tatacgtcag ctgggcgaat cacaccgcca aaaacaaaaa acgtttcaga 1254121 tgctgaacaa tacgactcct tttttggttt ttttgcagca ggaggcggag catcgctaca 1254181 agttaatcga acagctggcg acagctttgt ttgagaaagg ctatgttgat aaggactatg 1254241 cggttcatgc ggtgatgagg gaaaaaatgt cggctacaaa tattgggtca ggcattgcca 1254301 ttcctcatgc aaacgctaaa tttattaaac aatcagcaat cgcgattgcc acattaaagg 1254361 agccgcttga atggggaaat gaaaaagttt cgctcgtttt tatgctggct gtcaaacacg 1254421 aggatcaaac tatgacaaag cagctgttta gcgagctttc atatcttagc gagcagccgg 1254481 ccttcgtcca gaagctgacg aaagaaacca atgtcatgac atttttatct catttggatt 1254541 attaaaagca gggattattc cttgcttttt ttgttatagg gaaaaatgcc tttattaccg 1254601 gaacctatgg taaaaaaagc gattttaatg agctgatttc ggtatacagt tgagacaaga 1254661 tcttattatt cacactttaa aggaggtttc ctatgaaact gttagcgatt acatcttgtc 1254721 cgaatggaat cgcccatacg tatatggcag cagaaaatct gcaaaaagct gctgacagac 1254781 tgggcgttag catcaaagtt gagacccagg gagggattgg tgttgaaaat aagctaaccg 1254841 aagaggaaat tcgcgaagcg gacgcaatca ttattgctgc agaccgttcg gtaaacaaag 1254901 accggtttat aggcaaaaaa ctgctgtctg tgggggtaca ggacggtatc cgcaaaccgg 1254961 aagaattgat tcaaaaagct cttaacgggg atataccggt ctatcgttcc gctacaaaat 1255021 cggaatccgg taatcatcag gagaagaaac aaaatccaat ttaccgtcat ttaatgaacg 1255081 gcgtttcatt tatggttcct ttcattgttg tcggcggatt attgatagcg gttgcattaa 1255141 cgcttggagg ggagaaaaca cctaaaggct tagttattcc ggatgattcc ttctggaaaa 1255201 cgattgaaca gatcggcagt gcttcatttt catttatgat tccgatttta gccggctata 1255261 tcgcctatag catcgctgat aaaccggggc ttgtgccagg tatgatcggc ggttatattg 1255321 cggcgactgg aagtttttat gacagcgcaa gcggcgccgg attcctcggg gggattattg 1255381 ccgggttttt ggccggatac gcggcacttt ggatcaaaaa attaaaagtt ccaaaagcca 1255441 tccagccgat tatgccgatt attattattc cggtgtttgc atcactgatt gtaggtttag 1255501 cgtttgtgtt tttgatcggc gcgcctgtag ctcaaatttt cgcctcttta acagtttggc 1255561 tggcggggat gaaagggtcg agctcgatcc ttctggcatt gattttaggg gcgatgatct 1255621 catttgatat gggcggtccc gtaaataagg tggcgtttct gtttggatcg gcaatgattg 1255681 gagaaggaaa ttatgaaatt atgggaccaa ttgctgtcgc catttgtatc cccccgattg 1255741 gccttggcat tgcgacgttt ttaggaaaaa gaaaattcga ggcatctcaa agagaaatgg 1255801 ggaaagcggc atttacgatg gggctcttcg gcattactga aggagcgatt ccatttgcgg 1255861 cgcaggaccc tctgcgcgtt attccaagta ttatggcagg ctcaatgaca ggttctgtga 1255921 tagccatgat tggcaatgtg ggagacagag tggcgcacgg cggacctatc gttgcagtgc 1255981 ttggcgcagt tgatcatgtc ttgatgtttt ttattgctgt gattgcagga tctcttgtca 1256041 ctgctctgtt cgtcaatgta ctaaaaaagg atattacggc gtctcctgtg ctcagtgaaa 1256101 ctgcaccgac ctccgcgcca agtgaagctg cggcagcaaa tgaaataaag cagccaattc 1256161 aaagccaaaa agctgagatg tcggaattta aaaaactgac agacattatc agcccggaat 1256221 taattgaacc aaatttatcg ggggaaacga gtgatgacat catagatgaa ttgattcaga 1256281 aattgtcacg aagaggtgcg ctgctttcag agagcgggtt taaacaagcc attttgaatc 1256341 gtgaacaaca gggaacaacg gcgattggca tgaatatcgc gattccgcac ggaaagtctg 1256401 aggcggtcag ggagccgagt gttgcctttg ggatcaaacg atcaggcgtt gattggaata 1256461 gcctggatgg atcagaagct aaattaatct ttatgattgc tgtaccgaaa gagagcgggg 1256521 gaaaccagca tctcaaaata ctgcagatgc tatctcgaaa gctaatggat gacaattata 1256581 gggagcggct gctctccgtg caaacaacag aagaagcata caagctgcta gaagaaatcg 1256641 aataaagcgg gggattttca tgacgactga accgttattt ttcaagcctg ttttcaaaga 1256701 aagaatttgg ggcgggaccg ctttagctga ttttggctat accattccgt cacaacgaac 1256761 aggggagtgc tgggcttttg ccgcgcatca aaatggtcaa agcgttgttc aaaacggaat 1256821 gtataagggg ttcacgctca gcgaattatg ggaacatcac agacatttat tcggacagct 1256881 tgaaggggac cgtttccctc tgcttacaaa aatattagat gctgaccagg acttatctgt 1256941 tcaggtgcat ccgaatgatg aatatgccaa catacatgaa aacggtgagc ttggaaaaac 1257001 agaatgctgg tacattattg attgccaaaa agatgccgag attatttatg gccacaatgc 1257061 aacaacaaag gaagaactaa ctaccatgat agagcgtgga gaatgggatg agctcttgcg 1257121 ccgtgtaaag gtaaagccgg gggatttttt ctatgtgcca agcggtactg ttcatgcgat 1257181 tggaaaagga attcttgctt tggagacgca gcagaactca gacacaacct acagattata 1257241 tgattatgac cgaaaagatg cagaaggcaa gctgcgcgag cttcatctga aaaagagcat 1257301 tgaagtgata gaggtcccgt ctattccaga acggcataca gttcaccatg aacaaattga 1257361 ggatttgctt acaacgacat tgattgaatg cgcttacttt tcggtgggga aatggaactt 1257421 atcaggatca gcaagcttaa agcagcaaaa accattcctt cttatcagtg tgattgaagg 1257481 ggagggccgt atgatctctg gtgagtatgt ctatcctttc aaaaaaggag atcatatgtt 1257541 gctgccttac ggtcttggag aatttaaact cgaaggatat gcagaatgta tcgtctccca 1257601 tctgtaacat ggcagggctt gagaaataaa tttgcgagtg aagacgccta ttctccagca 1257661 atgatctaaa taaaataaga gtttaatagt tggagaagaa atgttacact cttttctgta 1257721 tatggtaaag aatgaaaaaa cacgattcgg ttggtagtcc ggatgcatga ttgagaatgt 1257781 cagtaacctt cccctcctcg ggatgtccat cattctttaa tatcttttat gaggagggaa 1257841 tcgttatgaa attaacgatt tactacgatg gtcagttttg ggtaggcgtt gttgaagttg 1257901 tggacaatgg aaagctaaga gcctttcgtc atctttttgg caaagagccg agggattctg 1257961 aagtattaga gtttgttcat aaccaacttt tgaatatgat ggcccaagct gagcaggaag 1258021 gagtgcgttt acaaggcagg cgtcaaaaaa agatcaatcc aaaaagattg cagcgccagg 1258081 tttcaaaaga gttgaaaaac gccggagtaa cttctaaagc tcaagaggcg ataaagctag 1258141 agcttgaagc aagaaagcaa aagaaaaaac aaataatgaa agaacaacga gaacatgtaa 1258201 aagagcaaag gtatatgctc aaaaagcaaa aagcgaaaaa gaagcacaga ggtaaataat 1258261 ccaaacaaaa gcaggcgcag tgcctgcttt tgtaattaag gactctactt tgtaacatat 1258321 atccaatgtt tatactccgc tgatttatga ttcaatataa accctaactt ctccaaggtt 1258381 ttttgtgagc ctagattatc atgttcgcat cttgcggtga tccgggatac tgtttctcgg 1258441 cttaatgccc agtttattag tttttgggcg gcttccacac aataaccttt gcggcgatga 1258501 cttttatttg ttgcaaaacc gatttcaatc atgccatttt cgtctgggtc acctaaaaat 1258561 ccagttcccc caacaatttc ataattgtcc ttctttacaa taatccatga atcaaatcct 1258621 tttgttccat tgtttttgac taaaatctcg cggaaataag gtatcgcttc aaaaaaatca 1258681 gaatttggcc attcaccatt tgtttcatag cctaattctt tgatagcctg atgatcttgt 1258741 ttagacgcgg cgtcaagaag gggaatatca atcgtttgta atcgtaatcg attcgtttca 1258801 aggagaacca tatatttaat cctcttttct ttttactggg aataatgata acatataaca 1258861 attttctctg gtaccttggc agtagagaaa gatgaaaaaa ttgaggggga ttgaaagagt 1258921 gacaggtgag agtttgccca gaccaaaaac gggtaggaaa atgctgatgt taatgtgtcc 1258981 ctacccgttt ttctgttcct gaatgcaggg tttctgataa catgttgtgc taccttttcg 1259041 caatcaaata aagcgatatg gctctttggg tttgcacagg attatgaatg ataatgaccc 1259101 attggtttct tcgtcttgga aagcttgcta ccgcatacaa tggagcagta tcgcgcggag 1259161 tgaacccacc atttatcacg ttgatatctc ttccttcaag atgacaaact aagtattcac 1259221 ctggattgat gacctgttgg ttcgtccatg cgtaagaata aaagccgtct ccaagatctt 1259281 cggtggaaga tggggggaca aagccatcta cagtcaatgt gatttctctt cttcgctgtc 1259341 tttctgaaaa gtctggactt ctttgagggt tatgagtatg tgaaaagtaa ggaattaacg 1259401 cagggccata aaagtaatga tacaaagcaa ccactccttt attttccatt catacaaatt 1259461 gtatgtggga gttatttgtt cattcctgtt ttgttccatg tagactaata atgggctata 1259521 ggcgtccaag gaaatcaatt tgtccttccg ttgattcaat gctagtaacc ttgaaaatgc 1259581 aggttaggat gatagaattt acatattact gcaagaagtt agacatacat cattttgata 1259641 gtgggtgaaa acaatggcga aaaaaatggc aaaaacaaat gcggttcgtc tgatagaaca 1259701 gcagaacatc tcttatgagg tattagggta taaaacagac ggccagccgg tagatggcat 1259761 ctctgttgcg gaaaaaatcg gttattcttt gaaatatgta tataaaacgt tggttgcagc 1259821 agcaggaaca aatcattatt atgtctttgt tgtacccgtt gcagaagagt tagatgtaaa 1259881 aaaggcagca aaggtgacag gggaaaagaa aatagaaatg attgcaatga aggagctgtt 1259941 agcggtaact ggctatcttc gcggcggctg ctcgccaatt ggcatgaaaa aattgttccc 1260001 gacctatatt gatgcatctg cagaaacgct tgattttatt attgtcagtg cagggaaaat 1260061 cggtatgcag ctaaagttgg cgccacaaga tttagccaga tcatgtgatg ccgcatttgc 1260121 agaaattgta tagatgcaga tataggggaa cgaaaaagct tagtcatatc gattaagctt 1260181 tttccgcatc cctttcaaat atgatttcaa aataagcagc tgccccatac ccatctatac 1260241 tgggagcgaa aatctgaacg aatctccagc ctcttttcgc ataatcatgg atgatttgct 1260301 ggtagtcttc tttaggcctt cttctcatcg tactcagctc aactcttacg aattcatatt 1260361 ctttcatcgt ttgatccctc ctattaaggt atacgtaaaa tggagcgaga agttccgaaa 1260421 acctaggtta aggtcggaaa gtatatttca ctcactaaac aaatccattt atgcctgatg 1260481 cctgcatgca tctgggaaga gttaaggggc tataaaaacg aattttaccg ggtcagcagt 1260541 ccaaatgaat ctcttgctta ttgcatttga ctgagtatat aagtaaaaaa agagcggcca 1260601 gaacatataa gaaggagatg atcattaacg cactcataac agggtagtgt ttagcggagt 1260661 agatgaaaaa atcaagctgt gaaatttgtt tggggctgct gacggcatca attccattaa 1260721 gcagttttga gagtttagca gtatagttcc aatcaaatcg atctgaaaca agctcgcttc 1260781 cttgatacca attaacagca gctaaaaaca gaaataccat aatagaaaat ccaagctgaa 1260841 caactaaaaa tattcccttc acttttgtat gacctccaaa tctatgaata tgggaaaatc 1260901 aaacaatata ttaccaccgt atgggttatt cttgcaattt cacttccata caactcaaac 1260961 gcaagtctat ttttttgttt gtttttggct tataatacct gatgatggaa aaagagtgcg 1261021 ggtttataga ttagagaaac aaatgtattt cttagcattt tttatttgtg gagagagtat 1261081 agaagcattc gattagatct gctttttcac agaaacggtt ttcatctgtt tgcctgagct 1261141 ttacaattgg ctggcaaaaa aacaatgatt tctttcaatc aaaacatgca acgatgcgac 1261201 acattttata tcttgatgac ttatttcatt gcctttaagt catcctatcg agaaagcgat 1261261 ggtattttat gaacaaagaa accctaaaaa acatactcat gattttttca atatgcgcaa 1261321 cactccgaga aaccgatggt atgcgcatag ctgatagctg gattttgagt gagattatac 1261381 gatttttgat ttgcatggtt gtgttttttg ccatgacatt tctattagat gctgtttttc 1261441 caaacaaaaa agagtcacat taatgtgtgg ctctttttgc atcatctgat cagaaacatc 1261501 ataaatgaat cgatcatcat gatgaagaac agcaagcaaa aataaataag cgagtagaca 1261561 aacatatcct ttgcccactt cacgtcatcg tctgttttga atcctttgat gctttttttg 1261621 atccatatgc ctccgagaac caaggcggct aagaaataaa atgggcttat atggccggtg 1261681 ccgagagaga aaggaaataa tagcgtgacc ggcaccagga cggcaatata ttgcatcatt 1261741 tttatttttg ttacatgatt gcctttgact actggcaaga gcggaacgcc agcagcgcga 1261801 tattcctctt tgcgtcttat cccaatcgcc caaaaatgcg gcggctgcca cagaaacata 1261861 atcgtgtaca acagcactgc tgtcatactg aagtcaccgg ttacggcaca ataccccatc 1261921 aatggcggcg cagctcctgg gaagctcccg acaaatgtgc tccacacaga cgttcgtttc 1261981 acccataccg tatagatgat cgcataaaaa ataaaggcgg ccagtccgag aaaggccgtt 1262041 aatggattga gggaataaag catggcaaga cctgcgattc ctaaaacaga gccatatgtt 1262101 aagatcatgg ctggcggcat tttccctgtg accgaggccc tgctgcgagt tcgtgccatt 1262161 tttgcgtcca tatgccgatc aaaatagttg ttatagacag tgccggaagc catcacaaac 1262221 gcggttccca acattgctgt taccattgtc atcaaaaaag ccaagccggt taacgttttt 1262281 tctgcgcttg caaacgcgat ccaaaacccg ccgaaggctg ctatcgagtt tgatatgata 1262341 atgcccggct ttgcaagttt gataaaatcg taaatggtta cccggttcga agcttttatg 1262401 tattttgttt cagatatggc tgcagaatct cttgtattct ccaaaaatag acgcctcccc 1262461 caaaactgca tgcttttgtt atcgtaacaa gagggggaca gaatcacaat tatttcccat 1262521 atttgtcatg atattgtcat ttttaaaaca aaaaaatggg gagctggact gcccccattt 1262581 tgatatgtgg cgactagtaa ccgtaacctc ccccatatcc tccgccataa cctccgccgt 1262641 aaccgtacca agggtagtaa ggcggtcgcg ggcgcgggta gtaataaggc gggcgcggat 1262701 aaaacgggta gaacggataa tacggtcttg gataataata aggcggataa aatggcggtc 1262761 tcggacgcgg ataataataa ggctgtcttt catcataagg ggtaatttgt tcaaatgact 1262821 gttcattcaa agggtaatcc aagaggaaaa cctccctagc tttttttatt ccttttacca 1262881 tattcctgat gcttaagttg ggtgtatgta cattcatgaa attcggtttt ttttatgatg 1262941 aaattcctta aaaaggattg acatgaactt ctaaatctca tagtattaca aatgtgaaat 1263001 aaatgttact acaatgttac aaaaacattt ctaaatagat acagttccaa ctgatgaaga 1263061 gtaaatcgaa atggctacga aagaaggagt ttttgttgtt ggcaaaaaga atcaaatggt 1263121 ttcatgtatt aatagcagtt gtatgtgtgg tgggccttat cggctttttc cataatcatt 1263181 cattgaaaaa agaaacggtc atgaataaag taagaactga ttctcaatat gggaatgttg 1263241 agatcgcaac gcttgtgaat gacgggaaaa cttttaatta cgcggtaaac tatcctgttt 1263301 tcaaaaatga aaaaatggat tcggcattaa aaagattcgc agaaaaagag gttcgtcaat 1263361 ttcaaaagga aacaaaggac gttgaccaag agcatacgac aaaacgcaac gaattaaatg 1263421 ttgattataa aattgtccat tatgccaaac agacagtggc gattgtattt aatgaatata 1263481 aatacatcgg cggggcacac gggcaaaccg tgaaaaaaac gtttaactat gattttagta 1263541 aacaagcgtt tctttccatt gatgatattt tcaaagagga cgctgactac ttacataagc 1263601 tttcgttaat cgcttatcac gagctgaaaa agaataagga cattgccgcg gacgatgcac 1263661 tgttaaagga agggacggct ccgaaaaaag aaaatttcag ccgctttgcc atcaaggagg 1263721 attatatcga actttacttt gacacatatc aggttgcagc aggctatctt ggagagcaat 1263781 cgattgccat taagaaaagt cttttgaaag acattctgaa agaacaatat attgataaag 1263841 caaaaaataa aaataaaatc aaagaacaaa agccgaagca tgaagtgatt tctttaccca 1263901 aagaggaaac agttgatcca aatcaaaaag tcattgcgct tactttcgac gacggcccga 1263961 atcctgcgac aacaaatcag attctagact ccttgaagaa atataagggt catgccacgt 1264021 tttttgtttt ggggagcaga gttcaatatt atccggaaac gctaataaga atgctgaaag 1264081 aaggaaatga ggttgggaac cattcatgga gccatccgct tctcacaagg ctttcagtga 1264141 aagaagcgtt aaagcagatc aatgatacgc aagacatcat tgaaaaaata agcggatatc 1264201 gtccgacgct tgtaagaccc ccatacggcg gcattaatga tgaactgcgg agtcaaatga 1264261 aaatggatgt tgcgttatgg gatgttgacc cggaagattg gaaagaccgt aacaaaaaaa 1264321 caattgttga ccgtgtcatg aatcaggcgg gagatggaag aaccattttg attcacgata 1264381 tttaccgcac ctctgctgat gcggccgatg aaattataaa aaagctcacc gatcaaggct 1264441 atcaattggt gacagtttct cagcttgaag aggttaaaaa acaaagagaa gcgaaataaa 1264501 ttagaaaagg ctgtccgtac ggacagcctt ttttctattt aataagagcc tgtggtggcc 1264561 caaacattta agtttggtcc tgaatacttg ccgaaagcgt aagaagtcct tggatctaaa 1264621 tcatatacca tcggtgtata gcaagacttt tggccggcca ccgcttttcc attgccgcct 1264681 gcagaatcac aattatatct ttttccgtct gtgttccggg taatctccgc atttgcttca 1264741 tagccagacg tcaatgtatt attcatcgtg atttttgccc aagccgtttt acatgtactg 1264801 ctgaatttaa gctcgactac tccgatgact tgattgctgg cattcactaa gtttgaggat 1264861 ttttttgtag agccgctgga cgcacaatca ttgtaataag ggctttttcc atcgtaggca 1264921 tgggtttccg ccttggcggg tgcacctttg acggcaaaaa caaatactac tgcgaataac 1264981 accaatgaag ccttcataaa cagtcttttc aatttatgac ctccttaata tggcaaacaa 1265041 taaatcatat ggaggaacaa tcaaaacatg catgcttttt tgtgaacaat aaaggcggcc 1265101 gggaggatgg agttcttggc cgcctctggt atgaggttat gcttttacat caatggtttg 1265161 tccgagagtt ggatgttgaa tcatctttaa ggtttgatcg gcattttgct gggcggtgtc 1265221 cagccttttt ttcgttaaag caatatttac attctgggca agggatgctt gatgcatcgc 1265281 aaccgataaa gcaggaatat ccatggttcc acctcctatg ccttacctat cggcgggttt 1265341 gtatgatttt acagtgaaaa atggcttaat ttctcttgtt gacccttacg ctgcggcata 1265401 tcgtatgttt ttgacaagga gggaatcagg atgaatctag taatggaaaa gacctttgag 1265461 caatacgaaa agctgttttc aatggaagaa cagaaaagag aagatgtatt tcggtatacg 1265521 atgatgaggc cgtttgaaaa gatgtggacc gccatccaag ttccgctgaa agcgaaggag 1265581 ccaaacggct atgatgtgat catggctgcg aaaatgctgg gctatttgga tgtccgtgat 1265641 gctgaaagcg gccagaaagc actacaaata ctgaaagaat cacatgtttc agagacagct 1265701 gaatctgcac ttcggcaatg catatttttt gctgagcgcg aacagctgcg ggtgaatgca 1265761 aaggagatca aattcggcct ttatatcgct gatccaaata agcttcagct gcaaaaaggc 1265821 tactgcgggt ttggcgggat accgggcttt attcatgtat ggattaatcc gaacagttat 1265881 aacctgccaa ggattccttc cattattgct catgagtttc atcataatgt gcggttttcg 1265941 tatatagatt ttcatcatgg ctctgtaagt gtcggggatt atcttgtgat tgaaggattg 1266001 gcggaatcat tcgccagaga gctgtttggt acggaacgat tgggcccttg ggtaactcgt 1266061 tttgatcatg aagacttgca atattccatt gatgtgatta atgaggtgct ggatgtgaaa 1266121 ggattttcgg aagtcagccg ttatatgttt ggtgatccaa ttgctaacga ccaaggcttt 1266181 aagcctgcag gtttatcggc ttttgcgggt tatgcagttg gctatcatgc cgttcagtca 1266241 tttatgaatc aacatcatat cacgataagc gaggccacac gtttggatgc gaagaccatt 1266301 atttctcaat gcggtctgtt ttctacatga aaaaagcgtc acatacagcg gcgctttttg 1266361 attcccaaaa ccagcagttc tatggcggca caggcggcaa ttccgattgt atatgcttcg 1266421 atatcgctcc ataaaaaacc gtaccctagt acaagcccgc caagagaagt atctctaatc 1266481 tggtcgatcc attcggcatg atagagctgg ctgaattcaa tgacaaaaca gaaagaaaga 1266541 ctgataatgc ccgttatcat tgtcttcagc ttccgaaata gaaatccgca tcccgtgaag 1266601 atcatggcgg cccacaacga gtctcccaga taagtattga gggtatcagg aagaacactg 1266661 gagaatgctc tggatccaag ccccagccca atgatcagta tggtgaaaac tgcatatatc 1266721 caacgatttc gcttcattgc gaattgatac cccgtctctg cttcatctcc ctgtattgta 1266781 aggaatatag cttttatttg tccactaaaa aagcggctga atagccgcgt agggtgttta 1266841 ttttgctttt aggtttacat ggtcggctgt ctgatccgtg cctattacaa aatggagttc 1266901 atagcggcct gtatcatata cataatcgat ttcatcggta aacgggacgg ttaacacccg 1266961 atttactggt cctaattgct tctgcagcac ttccggcgta actccgccta aattcagctg 1267021 ccgttccaca ccggttccaa agtagcggat ttctgaaatt gtcatgtctt tatgatagga 1267081 aaatccgtag cccggctgtc ccatattcca gtgatataaa tcaaatcgat tgtctccccc 1267141 gactggtctt tccggttccc caaacgcagc gtggacatcc ccttttgtgc ttttgttaat 1267201 ggtaaggcct tgcgcctgct gaggcatttc ccctttatag gcggtgttat agaggttttt 1267261 gacaagctca gcggctgatt gattcgtgtt ttctgagagt gtgtttgttt gagctgcggc 1267321 ctttgccggt gctgaaaagg acgcagcccc aaagccggta aaacagcttg ttactgctgc 1267381 tgccgcggtt atagcagaca ttgtcttttt catgttaatc cctcctaatt gatctaccat 1267441 tccgtttccc cgtgtttttg caacgaaaca tgtgagtgcg ctttgtatgt tttattgagt 1267501 tgttgtaagg gaactgaaat aggtaattcg gtatataaag caagaaaggg gaatggagat 1267561 ggctggcaag aaaacaatca caataaacgg cgttgaaatg gaagcgtccg aggaacagac 1267621 ggtgctgcag cttttgaata acagctcgat tgaagtgccg caagtttgct atcatccaag 1267681 cttagggccg attgagacat gtgatacgtg catcgtcagc atcaatggtg agctgaagag 1267741 gtcgtgctcc gctgaattaa aggatgggga tgtcattgat acgctctcac ctgacgtgaa 1267801 aaaagcgcag gtcatcggga tggacaagat tttatataat catgagcttt attgtacagt 1267861 ttgcgattac aacaatgggg gatgcgaaat acataatacg gtgaaggaaa tgaaaatcaa 1267921 tcaccaaagc attccgtttg atcacaagcc ataccataag gatgaatccc atccgtttta 1267981 tcggtatgat ccagatcaat gtatattgtg cggacgctgt gttgaggcat gccaagacgt 1268041 tcaggtaact gaaacgctga ccattgactg ggagcggaaa cgcccgcgcg tcatttggga 1268101 taacgacgtg ccgatcaatg agtcgtcatg tgtgtcatgc ggccattgtt caacggtctg 1268161 tccgtgcaac gcgatgatgg aaaaaggaat ggaaggggaa gccggatatt taacaggcat 1268221 caataacgaa acgctgcgac cgatgatcga gatcacgaaa ggcgtagaga caggctacgg 1268281 ctcgattctc gcgatttctg atatggaatc ggccatgcgt gatgaacgaa tcaaaaaaac 1268341 gaaaaccgtc tgcacgtatt gcggcgtcgg ctgcagcttt gatgtctgga caaagggcag 1268401 agacattctg aaagtagagc cgcaggagga agcgcctgcc aacggcattt ctacttgtgt 1268461 gaaaggcaag ttcggctggg atttcgttaa cagcgaagaa cgcctgacaa agccgctgat 1268521 ccgtgaaggc gatcatttcc gtgaagcaga gtgggaggag gcgttattgc tgatcgccag 1268581 caagttcact gaattaaaag aggcgtttgg cccggattct ctcgctttta ttacatcttc 1268641 taaatgtaca aatgaagaat cctatcttat gcaaaagctg gccagagggg tcattggcac 1268701 aaataatgtg gacaactgct ctcgctattg ccaatctcct gcgactgccg gcctgttccg 1268761 gacagtcggc tatggcggtg attcaggatc aattacagat atcgcgcaag cggaccttgt 1268821 tttgattatc ggttcgaaca cgtctgagtc gcatccagtc ttatccactc ggattaaacg 1268881 ggctcataag ctgagagggc agaaagtgat cgtcgcggat atcagaaagc acgaaatggc 1268941 agagcgctca gatttatttg tccagccgcg tgccggatcg gatatcgtct ggctgaatgc 1269001 gatcgccaaa tatttaatag aaaacggcaa ggccgatgaa cgatttttga gagaaagagt 1269061 gaacggacgg gatgaatatg taaaaagcct cgcgccgtac acacttgaat atgctgagga 1269121 gaaaaccggg attgatcaag aaacccttat ccaaatggca gagatgatcg ggcaagctga 1269181 cagtgtgtgc gcattgtggg cgatgggcgt gacacagcat attggaggaa gcgacacgag 1269241 cacggcgatc tctaatctgc tgcttgtgac aggaaactac ggaaaaccgg gagcaggttc 1269301 ttacccattg cgcggccata acaacgtgca gggagcaagt gactttggga gtatgcctga 1269361 cagactaccg ggctatgaaa aagtgacgga cgaacaagtc cgccaaaaat acgagcgtgt 1269421 gtggggtgtg ccgctgccga aggagccggg tatgaccaac cacgaaatga ttgaaaaaat 1269481 ccattccgga cagttgaaag cgatgtatgt aaaaggtgaa gaaatgggcc ttgtcgactc 1269541 caatatcaat catgtacacg ctgcatatga aaagcttgat ttctttgtgg tgcaggacat 1269601 tttcctttca cgtacagcgg agtttgctga tgtggttctt cctgcgagcc cgagccttga 1269661 aaaagaagga acgtttacaa acacagaacg ccggattcag cgtttgtatc aggtatttga 1269721 accgctgggt gaatcaaagc cggattggca gattattatg gaggttgcca ataagcttgg 1269781 cgccggctgg ctctatgagc atcctgcaga cattatggag gaagcagcca agctgtcgcc 1269841 gatttatgcc ggtgtcacct atgaacgtct tgagggctat aattccctgc aatggcctgt 1269901 aaacgctgat ggaaaggatt cgcctttact ctttacagag cgcttccctt tcccagacgg 1269961 caaggccatt ctctaccctg tccagtggac agagcctaag gaattcggtg aggaatatga 1270021 tatccatgtc aacaatgggc ggctcttgga gcacttccac gaagggaacc tgacttacaa 1270081 atcaaaaggg atttcggaga aaacaccgga agtgttctta gaaatttctc ctgagcttgc 1270141 ggcagaacga gggattcagg acggaaccct cgtcagactc acatcgcctt tcggaaatgt 1270201 caaagtgaag tgcctgatta ctgatcgagt caaagggaag gaagtatatc tgccaatgaa 1270261 cgattcaggg gaagcggcga tcaacctgtt aacaggcagc catgccgata aggataccga 1270321 tacgcctgct tacaaagaaa catcggccaa gatggaaatt ttgaagcacg acggaatcag 1270381 cccgctgcct aagatcaacc accgcaacgg caatccgcag ccgcaaatcg gtgtgcaggt 1270441 tcataagaaa tgggcgcgga aggattatat tttccctggt gacgctgtga aaagggggat 1270501 gggccataat ggctaaagcg attaaacgaa tccaaaaaat cgaggtaaca gaagaggatc 1270561 agcgaaagcg tgatttgcgg gaaattgaag atgctctaat tgaccacaaa gaagcgattc 1270621 tcgaaacatt gcatatgctg ggccatatga acgagcgcgg ggtcctgccg ttgctccgcg 1270681 gcctttttgg tcaaggggat aaagttcttg atatcctggt gaaaaaggca gatacagagg 1270741 aaacagccaa tacgctgaaa aatctgcttc ttctgtttgg aacactcggc atgctggacg 1270801 tgaagcagct ggagcctctc attttgaaag tgaatgcggg tgtggcaagc gctgtagagc 1270861 agaaaaacag tgaagaaaag acaggttatt ttgatattat ccgctcgcta aaagacccgg 1270921 aaatcaacaa atcaattaca ctgctctttt cctttttaaa aggaatggga caagatacaa 1270981 aggagctgga acgcacgacg cagcctccgg aacaccaaaa acatcatcag gaaccccgag 1271041 agaaaagagg aatgaataag cgagattgac ctcccacccg agcggcttca gccagctcgg 1271101 gttttttgat gaaaaggtct aatggactag taaaaaatat tcaaatacta ggaagaagta 1271161 agattgtgat gaatgagata gaaataatcg ttactttctt acctgttaag aaaagggaaa 1271221 atctgattat aatagaaatc gattacttta gatgggggaa caatcatgaa aaaagtctta 1271281 ttactattat ttgtcttgac gatcgggtta gcgctttctg cgtgcagcca atcgagcgat 1271341 gcgtcagaga aggaaaaacc gaaagagaaa aaatcgcaag aagagcttga aaaggaactt 1271401 gataaggaat tgaaaaaagg cggtgagccg aagaccaaaa aagatgatca aatacataaa 1271461 ataggagaaa catttaaagc aggacatacg aattttacag tgaataaagt tgatagagtg 1271521 caaaaaggtg aatatatgaa tgttggcgga gctgtaaatg aggagacaaa aacaataaaa 1271581 gatgatgagg aacggcttat tatagaagtt acgatggaaa atatagggga agattcaata 1271641 agctacaatt ttatcgggtt tgatttaaga gataagaatg atcaatcagt gcggcctgtt 1271701 ttttctatag aagagaaggg cagaatcctt atgggaggaa cactagtatc ggggaaaaag 1271761 gttacaggtg tactcagtta tgtcatccct aaaggagaac agaaacatta cacactggta 1271821 tataatccgt ttttagctga tacaaatagc agtaatacag aagagagagt aaaggacgat 1271881 attgattact tggtgaagtt agattagatg ctaatttaca gttgcacgtt tttcatctgt 1271941 ggaaaacgtg cattttttat agcgaaactt gacttgaaag gatgagtgat aaaagtgcaa 1272001 accaaatggc tggaacgggc acagcggatt cgggcgatcg cccaagcggg gcttgctttt 1272061 tccaaggatg tgtacgacag ggagaggtac gaagagctaa tgaagcttag cgcggaaatg 1272121 atggcggatt actcggagaa ggacattgaa gttatcactg atttatggca aggcgagaag 1272181 ggctatccaa caccgaaagc ggatgttcgc ggcgctgtat tcagagagaa tcagattttg 1272241 cttgtccggg agaagcatga tgagctgtgg tcgctgccgg gcggattttg cgagattggt 1272301 ttatcgccgg ctgaaaacgt tgtcaaggaa atcaaagaag agtcggggta cgatacagag 1272361 ccgtctcgat tgctggccgt gctagacagc cataaacact ctcatccccc tcagccttat 1272421 cactattata aaatcttcat cgcatgcagc atgacggacg ggcaggggga aacagggatc 1272481 gagacgaatc atgccgcttt ttttccggaa gacagactcc cgccgctttc tcctaaacga 1272541 aacacaccct cacagcttag catgctgttt gactttttgc gccatccgga caagaaaacg 1272601 atatttgact aaaaaagaaa gagcctgtgg gctctttctt ttttataatg taatgtgttt 1272661 ttcgttggcg agtttcagaa gggtcaaaat agaatcggct tgtttatggc cgagtttttg 1272721 ctttaatttg ttttcttcaa ctaatcggct gccataaatt ttgacggagg ctttgtcgac 1272781 gacagtatgc cagttttcct gtttttttcc ctcaacaagc ggtttttcat gtctctcaga 1272841 aaaagagaac acaaagagta cgaatgcaag tgaaagtagg attccgacaa cttgtttttt 1272901 gtaatcagtc tgtgctgcca cgttgttctc tccttcacct tttaccttct atttaatcat 1272961 agaaccaaat tattttacat aatgggaaag tcatttttgg agttagtgca tttggttgaa 1273021 aacagagacg ttttttgagc ggagcggtgc aattgaatcc atattggatt tgcgtgctta 1273081 tgcctaaggt cacgttgtga gccaaaacag cagtgcagaa tagaaaaaaa ttgaaagatt 1273141 atggtaagat gaacgaaatt cgagggggaa tatatgatgc ctgcatcgaa catcgtgatc 1273201 gcctgcctgc tgttatcaat ttaattattt gtggtagtcc ctctcttttt cgaaagcggg 1273261 aggtgaagtg gaacattaat tgctgaattc tttcaagggg agtgaccgta catgaatgtg 1273321 ttaaaccgcc ggcaagcctt gcagcgagcg ctgctcaatg ggaaaaacaa acaggatgcg 1273381 tatcatccgt ttccatggta tgaatcgatg agaaaggatg cgcctgtttc ctttgatgaa 1273441 gaaaaccaag tgtggagcgt ttttctttat gatgatgtca aaaaagttgt tggggataaa 1273501 gagttgtttt ccagttgcat gccgcagcag acaagctcta ttggaaattc catcattaac 1273561 atggacccgc cgaagcatac aaaaatccgt tcagtcgtga acaaagcctt tactccgcgc 1273621 gtgatgaagc aatgggaacc gagaattcaa gaaatcacag atgaactgat tcaaaaattt 1273681 caggggcgca gtgagtttga ccttgttcac gatttttcat acccgcttcc ggttattgtg 1273741 atatctgagc tgctgggagt gccttcagcg catatggaac agtttaaagc atggtctgat 1273801 cttctggtca gtacaccgaa ggataaaagt gaagaagctg aaaaagcctt tttggaagaa 1273861 cgagataagt gtgaggaaga actggccgcg ttttttgccg gcatcataga agaaaagcga 1273921 aacaaaccgg aacaggatat tatttctatt ttagtggaag cggaagaaac aggcgagaag 1273981 ctgtccggtg aagagctgat tccgttttgc acgctgctgc tggtggccgg aaatgaaacc 1274041 actacaaacc tgatttcaaa tgcgatgtac agcatattag aaacgccagg cgtttacgag 1274101 gaactgcgca gccatcctga actgatgcct caggcagtgg aggaagcctt gcgtttcaga 1274161 gcgccggccc cggttttgag gcgcattgcc aagcgggata cggagatcgg ggggcacctg 1274221 attaaagaag gtgatatggt tttggcgttt gtggcatcgg caaatcgtga tgaagcaaag 1274281 tttgacagac cgcacatgtt tgatatccgc cgccatccca atccgcatat tgcgtttggc 1274341 cacggcatcc atttttgcct tggggccccg cttgcccgtc ttgaagcaaa tatcgcgtta 1274401 acgtctttga tttctgcttt tcctcatatg gagtgcgtca gtatcactcc gattgaaaac 1274461 agtgtgatat acggattaaa gagcttccgt gtgaaaatgt aatagataag gagactggag 1274521 attcatgaaa aagtaccata tttcgatgat caatatcccg gcgtacggac atgtcaatcc 1274581 tacgcttgct ttagtagaga agctttgtga gaaagggcac cgtgtcacgt acgcgacgac 1274641 tgaggagttt gcgcccgctg ttcagcaagc cggtggagaa gcattgatct atcatacatc 1274701 cttgaatatt gatcctaagc aaatcaggga gatgatggaa aagaatgacg cgcccctcag 1274761 ccttttgaaa gaatcactca gcattctgcc gcagcttgag gagttatata aggatgatca 1274821 gcctgatctg atcatctatg actttgttgc gctggctggt aaattgtttg ctgaaaagct 1274881 taatgttccg gtcattaagc tctgttcgtc atatgcccaa aatgaatcct ttcagttagg 1274941 aaatgaagac atgctgaaaa aaataagaga agcagaggct gaatttaaag cctacttgga 1275001 gcaagagaag ttgccggctg tttcatttga acagttagct gtgccggaag cattaaatat 1275061 tgtctttatg ccgaagtctt ttcagattca gcatgagacg ttcgatgacc gtttctgttt 1275121 tgtcggcccc tctctcggag aacggaagga aaaagaaagc ctgttgattg acaaggatga 1275181 tcgcccgctt atgctgattt ctttgggtac ggcgtttaac gcatggccgg aattttacaa 1275241 gatgtgcatc aaggcatttc gggattcttc atggcaagtg atcatgtcgg ttgggaaaac 1275301 gattgatcca gaaagcttgg aggatattcc tgctaacttt accattcgcc aaagtgtgcc 1275361 gcagcttgag gtgttagaga aagctgattt gttcatctct catggcggga tgaacagtac 1275421 gatggaagcg atgaacgcag gtgtgccgct tgtcgtcatt ccgcaaatgt atgagcagga 1275481 gctcactgca aatcgggttg atgaattagg ccttggcgtt tatttgccga aagaggaagt 1275541 gactgtttcc agcctgcagg aagcggttca ggctgtatcc agtgatcaag agctgctcag 1275601 ccgcgtcaag aatatgcaaa aggatgtaaa agaagctggc ggagcggagc gtgcggcagc 1275661 tgagattgaa gcgtttatga aaaaatccgc tgtcccgcag taaaaacata aaaaccgaaa 1275721 tcaatttgat ttcggttttc tgtttaaata ttttttttca tcccgcatct ccggcattct 1275781 ctaagaaatt ttccgccttt tacagagctt ttgaacagtg tgtaatcaca gttgtcgcag 1275841 cgcccgctgc gggcatccgg atattcattg aattcgtaaa caatcgatgt atcgtagcct 1275901 tttgtttcat attcttcttt tttggtttcc atgtcgatcc tccgttacaa gacgtgtctg 1275961 ctgtttatct tacagcaagc ttccggcgta ttcaatggat tttaggaggt tgggtttatc 1276021 ttgatttctc ccttggtttg cgccaaaata gctttattaa gcttatatac ataaaaagcc 1276081 tatgcaaaga ggagaggaaa cgggtatggg aaaagggtta cttggaaaac gcgtggcaat 1276141 cggtggctca cgaaaaacgg aagaaattag tacaatcatt gaaaaacagg gcggaatacc 1276201 tgtcatccgg cctctccaag gtacagttta cttagcagag aagcaggtgg agccggattt 1276261 gcggacgttt gcggaagaaa aagctgactg ggtcattttc acgacaggca tcgggttgga 1276321 gactcttgtc gatatggcag agaaaattgg actgaaagat gagtttctgc aggccattcg 1276381 ccaagcgaaa gcggcatgcc ggggatacaa aacgctgtct gcgctgaaaa agcttggaat 1276441 cacaccggaa gcttcggatg aagacgggac aacaagaggc ttaatccgtt ccttggagcc 1276501 tcacgacttt tcaggaaaaa cagtcatggt gcagcttcat ggcgaaaaag cgccggctct 1276561 catggcattt cttgaagaaa aaggcgcgtc tgtcctgccg attctgcctt atcagcacat 1276621 cccgccggag gaggaaacgg tggagcggtt atgccgagag ctgatgaacg atgaggtcga 1276681 tgccgtttgt tttacaacgg ccattcaggt tcgttccctg tttgattttg ccaaggggcg 1276741 aggttatatc aatgaagtga agaaggtatt cgaagaacgc gccatcgcag ctgctgtcgg 1276801 aaaagtgact gctgaagcac tgcgggaaga gggcattacg agactgcttg cgccagagat 1276861 tgagcggatg ggtgcgatga ttgttgagct ggccaagtat tatgaagaaa aggaataaca 1276921 agtacaaaaa gccgcttttc cctcggaaag cggcttttgt ctgtcattca ttttgcttca 1276981 gctgctgatg aacggtgaat aatgatgggt atgtcagcac gcttaagatt acacaagtca 1277041 gcgcggctga ggccatcgtt gtaaacacga ttaagagttg aaagcgtact gcctgaatcg 1277101 ggtccgcgcc ggctagaatc tggccagtca tcatgccggg aagctggaca agacccagtg 1277161 ttttctggct ttcgagcgtc gggatcatac tcattttcat cgctgaggta agaatgcgct 1277221 gtatggattg cttcggtgtg ccgccaagtg acaatattaa ttgaatttct tctttgcgaa 1277281 cgccgacttc tgagttaagc cggtttagaa acaaacttga gagcaccatc gaatttccga 1277341 tgaccatccc gctgatcgga atgacatatc gtgccgtaag cggaatgata tgaagagaca 1277401 gcagaattcc ctgcgtcaca atttctacga ttgctaacgc ggcaaacacc ctccaaaacg 1277461 aaccgatagt atttttcttt cgcttgatga cattttgcgc cgccaccgcg agcattaaca 1277521 gcaccatcag caggataaaa acagggtggt ctccgcgaaa aatcagcgac aaaacataac 1277581 cgatgataag cagctgcacc gcggcccgga tggtggcgat gatcatgtct ttttctacac 1277641 cggctttaaa ggattttgat aaaaacaagg cgatcaaaac aaagatcatc gttaaagaga 1277701 gagaaaggta atccattacc gagtgcctcc cttcaaaaat tctttcgctg cttcatgctg 1277761 cggagcggag aaaaatgtgt cggtttcagc gatttcaagc agccggccat ctgccataaa 1277821 ccaaatggta tcggctattc gttttgcctg ctccatatta tgagtgaccc acatgactgt 1277881 ccattttttc tcttgatgct gacgtttgat cagttcttca atctcaagag cagagaccgg 1277941 gtccaaggcc gatgtgattt cgtccaacaa tagaatggag gaaggatttg agagcgttct 1278001 ggccagtgac agtctttgcc gctgcccgcc cgataagtct ctggcgcttc tgtctaacaa 1278061 ctctggcggc agccctgcaa gcgaagccag cttttcagga gagtacagct gggattgatg 1278121 cagcctttgt acaagactta aattgtcacg cactgtcccg tcgagcacgg gagccgattg 1278181 aaacgcgagg gctgccgttc gcctcagctc attgacattc cattctctga cttcctttcc 1278241 gtatatgttg acttcgccgc tgtcaggcgt tctcattaaa ttacacatag aaaggagggt 1278301 gcttttgcct gagccggaag ggcctaaaac ggctacgatt gcaccctgtt gaatgtctcc 1278361 ggtgacatcc tgcagcacat cataggtttg tccatcttgt ttatagcttt ttctgactga 1278421 tctgaaggag atggctggta tgttttgtgt ttgatcgttt gcttccatta caataatcac 1278481 ctttcaatat aagtaggctg acattatatt taactataac gtgaaacaga ttccttttgg 1278541 tagcacaaat aaaggagaac aggctttcac ccattctcct gcagatgcta cgcagtcaga 1278601 tttgactgtg ctttcttttt cggttttctc ggctgtgaag cgaaggtatg taacatcatc 1278661 cccgctatta taatgaacaa accggcaaat gataatagag atgggaaaac gcctgacagc 1278721 agaacaattt caccaagcag cgcgaaaatc acttcaccgg attgagtggc ttcaacagct 1278781 gcgagttttt gcggattgtc tcttaccata tcagtggccc agaaaaataa aaccgtcgca 1278841 atgatgcctg agctgacggc aacgataaag gattgaacgg tttgacttgc tgttggaagg 1278901 ccatctgacc accagccgta agctgctaat ataagccaga atggaaggct tgccaatgtc 1278961 attccaagca cgcgctgaaa tgtatcaagc cggcctccgt attcttcgag cattcttcgg 1279021 tttcctaacg gataggcaaa agccgcaatg acaaccggca gcacactgaa aagcagcatc 1279081 ctcccagaaa gcgattctgc atgctgaagc tgaatcagag ccgctccaat caggatgatc 1279141 acagaagtgc caagtgaaac caggggaatc ttttggcgaa tgagctgcgg accgcccggc 1279201 atatcttgtt tgacataaaa caaaggagat aagagcaccc cggctacaat tgtaatttgc 1279261 caggttccag ctatgagcca ccccggaccg tatgcagccg caaatgtaat cggtgcgtaa 1279321 aaaagcacga aaccgacgaa gctccatttg atccaataaa acggcttttt cctcatttct 1279381 agtaagagag gcgtgaatgt ccctctcatg atgacaatca aacataaaaa tggcaccata 1279441 aaaataaagc gcagcgaaga gctccaaagc cagctgcctc ctgataactc catcgctctg 1279501 tttaatataa aggtaacggc gaaaaagagt gaagccaata ttccgataac gatagctttc 1279561 atgatatccc tcattctggc attatttttt tatactatac tattcggtat catgcagatc 1279621 aatggaatca tgagaaaaac atcatgtttg gcgaaccgct atatgtggaa gacaaaaaag 1279681 ggaggtgaaa ttgatggaaa gagagacaca gacatacttc tttccggatg acggcaggat 1279741 tccgaatcac cctgattttc cgctcgtggt gtatcaaaac gcgcttaagg acaccggact 1279801 ggcagagcgg atcgtcaccc ggcatggctg gtcaaacagc tggtcaggga gtgtttttcc 1279861 ataccatcat tatcacagca atacgcatga agtcctgatt gcccttagga gagaggctgt 1279921 gattcagttt gggggagaaa aaggggctgc catccctttc aaatcaggcg acgcagtcgt 1279981 gattccagcc ggagtcggac ataaaaagct cagctcaagc cccgatttta ctgtccttgg 1280041 cgcctatccc ggtggcgttc agtacgatat gaagacgggg aagccgaatg agcgggagga 1280101 agcggtcaaa cagattaagc aggcggcgtt gccggcgaat gatccgatca caggaaaaag 1280161 agagcctcta ttggaaatat gggtaaagtg aaggggagaa attgctggat tgtcaataac 1280221 tagtgccgca gaaacgatat gacatgagct ccatataaat taatttcata atcgaagcaa 1280281 ttcacgttca aattttgttc aaaaagtgtt atcatataga aggtaatcga attggagttt 1280341 tttgtgtttg ctattttcag agagagtaaa ggattttgac ttattcaatt gtttattttt 1280401 agataaaaat aatactgaat atggcaagat gaaaaactgg gtagtaaaca tttatttttg 1280461 taaatgattg tgcatgaatt cacaatcctt attcttatgc cttaaaagcg tgagacaggg 1280521 agaggcacta ccctttccaa aaaaatcagc aaactgctta tagtaaagga gaattggata 1280581 tgccagaaac aatcgatcaa acaaatgcgt ctgtcagcca aagccagcaa gatcttattg 1280641 atcagctatt aaagccagaa gttcaagaat cattgactgt tttagttgac cagcttccga 1280701 agctgactga gttagtgaat attttaacga agtcttatga tttcgctcag tctgtagcga 1280761 ctgacgaagt gttaaagagc gacacagtcg gtgcgatcac tgaaattctc gagcctgtaa 1280821 aagaaacagc gaaagaagta gctgcgactg cgatcgaagc aaaagaccgc gcggaagcaa 1280881 gcaacgaaac aattggactt ttcggccttc ttcgcatgct gaaagatcct caagctcaaa 1280941 agctgttccg ttttgctaac agctaccttg aagtcatgaa cgaacgcgaa aaccaaaaat 1281001 aatctcagat tcaaattgat ataaaggacg gaggatatac gatgtcaaaa catattgtca 1281061 ttctaggcgc tggttatggc ggagttcttt ctgctctaac agttcgcaaa cattacacaa 1281121 aagaacaagc acgcgtgaca gtggtaaaca aatacccaac tcaccaaatc attacggaat 1281181 tacaccgcct tgctgcaggc aacgtgtctg aaaaagcggt tgcaatgcca ttagaaaaac 1281241 ttttcaaagg caaagacatt gatcttaaaa ttgcggaagt aagctctttc tctgttgata 1281301 aaaaagaagt tgcgcttgct gacggttcta cattaactta cgatgcgctt gttgtaggtc 1281361 ttggttctgt aacggcttac ttcggcatcc caggtcttga agaaaacagc atggtattga 1281421 aatctgctgc cgatgcgaac aaagtcttcc aacatgttga agatcgtgtg cgcgagtact 1281481 ctaaaacgaa aaacgaagca gatgcaacaa tccttatcgg cggaggcggc ttaacaggtg 1281541 ttgagcttgt tggtgagctt gctgacatca tgccgaacct tgcgaaaaaa tacggcgtag 1281601 accataaaga aatcaaattg aaacttgttg aagcaggtcc gaagatcctt cctgttcttc 1281661 cggatgatct tatcgagcgt gcgactgcaa gccttgaaaa acgcggcgtt gagttcttaa 1281721 caggtcttcc tgttacaaat gtagaaggaa acgtaatcga tctgaaagac ggatctaaag 1281781 ttgttgccaa cacatttgtt tggactggcg gcgtacaagg taacccatta gtcggtgaat 1281841 caggcctaga agtgaaccgc ggacgcgcga ctgtaaatga cttcctgcaa tctacatctc 1281901 atgaagatgt attcgttgct ggagacagcg cagtttactt cggtccagac ggccgtccat 1281961 acccgccaac tgcacaaatc gcatggcaaa tgggtgagct gatcggttac aacctattcg 1282021 cttacctaga aggcaaaacg cttgaaacat tcaagccagt aaactctggt acacttgcaa 1282081 gccttggacg caaagacgcg gttgccatca ttggtgctaa ttctacaccg cttaaaggtc 1282141 ttcctgcttc cttgatgaaa gaagcaagta atgtacgata tttgacacat attaaaggac 1282201 ttttcagcct ggcttactaa tccttttaat gaatctggca ttgccaaaag cattcctttc 1282261 cgagtgcttt ctggcaatgt ctttttttat gtttatgaca gcgttaacat ttcattttca 1282321 aaaaagagat tgatcccaaa ggaatataaa ggtaaaataa aaacaaatca aaatgttaac 1282381 gttaacattt tgaaatagaa tgaaagacgg tgaggacatg gaacccttca tgggcaaaaa 1282441 ctttttattg aaaaatgaaa ccgctgtcag cctctatcac aattatgcga aagacatgcc 1282501 aattattgat taccactgcc acttaagtcc gaaagaaatc tatgaaaata agacatttca 1282561 aaacatcacg gaagcctggc tgtatggtga ccattataaa tggcgcatca tgagagccaa 1282621 tggaattgag gagacataca ttaccggaga tgcgcctgat gaggagaaat ttatggcttg 1282681 ggcgaaaacc gtgccgatgg cgattggcaa cccgctctac aactggactc acttagaatt 1282741 gcagcgtttt tttggcattt acgagatttt aaacgagaag tccgggtcgg ctatatggaa 1282801 acagacaaat aaactgctca aaggggaagg cttcggggca agggatttaa tcgtgaaatc 1282861 aaatgtaaag gtcgtgtgca ccacagatga ccctgttgat tctcttgaat accatttatt 1282921 gttaaaagaa gacaaagact ttcctgtcag tgtgctgcct ggatttcggc cggataaagg 1282981 acttgagatc aatcgtgaag gctttcctga gtgggtgcag gcgcttgaag atgccgctgc 1283041 catatcgatt acaacctatg atgagttttt aaaggcgttg gaaaaacgag tgcgattctt 1283101 ccactcagcc ggcggcagag tttctgatca cgcgatagat acaatggtat ttgccgaaac 1283161 aacaaaagaa gaagctggac ggattttttc tgacagatta caaggaacag aggtttcttg 1283221 tgaagatgag aagaaattta agacatatac gcttcagttt ctttgcggtt tgtatgcgga 1283281 gctcgattgg gcgatgcagt ttcatatcaa cgctttaaga aacacgaata caaaaatgat 1283341 gaaaaggctc ggacctgata cagggtatga ttcaatgaac gatgaagaaa ttgctaagcc 1283401 tttatacaag ctgctgaact cagttgagat gaagaaccag ctgccgaaaa cgattttata 1283461 ttcactgaat ccaaatgata actatgtcat cgccagcatg atcaacagtt ttcaggacgg 1283521 tattaccccg ggaaaaatac aattcggcac agcctggtgg tttaacgata ctaaagacgg 1283581 aatgctcgac caaatgaaag cgttatcaaa tgttggcctt ttcagccgtt ttatcggcat 1283641 gctcaccgat tccagaagct ttctttcgta tacgcgccac gaatatttca ggcggatcgt 1283701 ctgcaatttg attggagaat gggtggaaaa cggcgaagtg ccgcgcgata tggagcttct 1283761 gggaagcatc gttcagggga tttgctatga caatgcgaaa cactactttc aatttcaaga 1283821 agagaaagca aacgtgtaac aaagtgtccg ctcagtatcg ctgagcggat cactatccga 1283881 aaattcttaa gacacagagg tggaacatgc gaactgaact ggcaaataag gttgtgtcgg 1283941 tcgaaacgga aaaaaggctt tcattgaaag agaaaatgtc ctatggcttt ggtgattttg 1284001 gcaacggttt tatgtttgat ctcggccaga tttatttatt gaagtatttc actgatgtag 1284061 cgggaatccc cgctgcgatg gccggcggca tttttttagt cagtaagctg tttgcagcga 1284121 taacagatcc aattgtcggc tcatcaatcg attatcgcaa aaacatcggc aaacggggga 1284181 aattcaggcc ttatctatta atcggcagca tcgtgcttgc ggtgcttact gttcttattt 1284241 ttctgtctcc caatgtatca acgaccggaa aactgatata tgcatatgca tcctatatga 1284301 tttggggcat cggctattcg tttgtgaata ttccgtacgg ctcattaggg gcagcgatga 1284361 ctcaaaattc tgaggaccgg acctccattt cgacgttccg ccaaatcgga tcacttggcg 1284421 ccttgtttat cacaagtgtg gccgtgatgc cgctgctcgt caagtttgat aatccgaagg 1284481 tcggctaccc ggtggtcatg ggcttgttcg ccgcgctcgg tgtgttttgg ttttatattt 1284541 gctaccgcaa ctgcaaagag cgcattatca tatcggaagc acccaaagaa aaattaacac 1284601 tctcatctgt cgtcaaaaca tttattacaa ataaaccgct gttaaccctt gtcctgatga 1284661 cgattttttc aatttccgca tacaacatta aatccgccat gctcgtctat ttcgcacaat 1284721 ataacttggg caatgttgaa ttaatggctt atatgaactt catcattatt ggttcttcct 1284781 ttttgggcgt cgtattcctt ccaaagctcg tcaagatgtt tggaaagaaa cgaacggcaa 1284841 tgatcggctt tggcatcagt gtggccgcgg atctgatcaa ctttatgctt ccatctaacg 1284901 tttatgtgtt tacaattctc gccagtatcg cctttatcgg aatcagtatc ccaaatggca 1284961 tcacgtgggc tcttgtctcc gatattatcg actatggcga atggaaatcc ggtgaacgga 1285021 aggaagcaac gacatattca cttttcaatt tctcaagaaa gcttgctcaa tctttgtctg 1285081 gctttctctc ggggatcggt ttggggatta tcggctatgt gccgaatgca gtccagacag 1285141 cacaggcgct gattggcatc aaagcgctgc ttcttctgta tccggccatt gctttggcat 1285201 tagcgatgtt cattatcggc tttctttata aactcacaga ccagcagcat gctcagatcg 1285261 ttcaggatct tcatcaaaag agctgacaat ataatataaa gaatatttaa aataatttgt 1285321 aaataaaatg tgtttgtagg ggtttcgctt ggagagtgcc caaaaaactg aaaaggaagg 1285381 aggcacttgc ttgaaaacga taacaattgc agctgaagaa gcaaaggaac tcgtttggca 1285441 aaagctggac ggtgccggtt tgaatgaacg agatgctgaa aaagtggcag atgttctcgt 1285501 gcacgctgat ttgcgcaatg tacattcgca tggcgtgctg cacacagaac actatgtgaa 1285561 caggctttta gcgggaggga tcaatcctgg ggcacagcct gtttttaaag agacggggcc 1285621 tgtgaccggg gtgcttgacg gagacgatgg tttcggtcat gtgaattgcg acatggcgat 1285681 ggaccatgca attgacatgg cgaagaaaaa aggagtcggc atggtcacgg ccgtaaacag 1285741 cagccattgc ggagcgctaa gctattttgt gcaaaaagcg gctgacgaaa agctgatcgg 1285801 aatggcaatg acgcatacag acagtatcgt tgtcccattt ggggggagga ctcctatttt 1285861 agggacaaat ccgattgctt acggagttcc ggctaagcat aaaaaaccgt ttatcctaga 1285921 tatggcgaca tccaaagtgg cttttgggaa gattctgcag gcccgtgaag agggcaaaga 1285981 aattcctgaa ggatggggag tcgatgaaaa cggagaagca gtaactgatc ctgacaaggt 1286041 cgtctcactt tcaacattcg ggggcccgaa aggctatgga ctatcgattg tagtggatgt 1286101 gttttccgga ttgctggcgg gcgcggcttt tggccctcat attgccaaaa tgtacaacgg 1286161 ccttgatcaa aaaagaaagc tggggcatta cgtttgcgcg atcaatccat ccttttttac 1286221 tgactgggat acgtttttag agcagatgga tgccatgatt gatgaactgc agcaatcacc 1286281 gccggctgtt ggattcgaaa gagtgtatgt gcccggcgag atcgagcagc tgcatgaaga 1286341 aagaaataag aaaaacggaa tttctatcgc ccggagcgtg tatgaattct taaaaagcag 1286401 gtgagtaaaa tgaaagcggt tcaagtgcga aaagcgtatg atctggtgac agcggaggtg 1286461 aagaagccag ttctttcaaa ggatgatgaa gtgctcgtga aagtcaagcg agtcggcatt 1286521 tgcggttcag acatgcacat ttatcatgga acgaatccgc tcgctaccct cccgagagtc 1286581 atcggacacg aggtaacggg acaagtggag gcagttggtg cgaatgtaca gagcctaaaa 1286641 cccggtgatc atgtggtgat tgagccgatt tcttattgcg gatcgtgcta tgcctgccgc 1286701 aaagggcggc cgaatgtttg cgccaagctt tctgtatttg gcgtacatga ggacggaggc 1286761 atgcgggaat atattgtgct tccggaaaga cagcttcacg cggtctcaaa ggacttgcct 1286821 tgggaggaag cagtcatggc cgagccttat acgataggcg cccaggcagt gtggagaggc 1286881 caggtggaaa aaggtgatac cgtcctgatc cagggagcgg ggcccatcgg gatctgtgtg 1286941 ttaaaaatgg caaaactggc gggcgctgct gtcatgatga ctgacttgaa caacgagcgg 1287001 ctggcatttg cgaaagaaaa cggcgccgat gctgttgtaa atgtccaagc agaacatgtt 1287061 gccgagcggg tccttgaatg gactgggaat gaaggagcaa acgtggtcat tgatgctgtt 1287121 tgcctgccgg agacttttgc actttcaatt gaggctgtgt caccggcggg acatgtggtt 1287181 gtgcttggat ttgatgaaag agcggctcag atttctcagc tgccaattac aaaaaaagaa 1287241 gtcacgataa ccggatcccg attgcagacc aatcagtttc caaaagtggt agagcttttg 1287301 aatggaggcc ggttaatgca taacgggctg gtgacccata cattttcagt tgatgacgtt 1287361 catcatgcat ttcagtttat taaggagcat ccagatcagg tgcggaaagc cgtcatcacg 1287421 tttgattaaa tgactgaatc cggaggtgcg agcatgaata tgacattccg atggtatgga 1287481 cgaggcaacg atacagtcac acttgaatac gtgaagcaaa ttcccggtgt caaaggcatc 1287541 gtttgggctc tccatcaaaa gcccgtcggc gacgtgtggg aaaaagaaga aatcagagcc 1287601 gaaactgaat atattcaatc ctatggtttt catgctgaag ttgtagaaag cgtgaatgtt 1287661 cacgaagcga ttaaacttgg gaacgaagaa cgcggccggt atattgaaaa ctacaagcaa 1287721 acgatccgca accttgccgg atttggcgtg aaagtgatct gctataattt tatgccggtt 1287781 tttgattgga cacgcacgga catgttccgg ccgctagaag atggatcgac cgctctgttt 1287841 tttgaaaagg ccaaggtgga aagccttgat cctcaagagc tgattcggac ggtggaggaa 1287901 gcatccgaca tgacactgcc ggggtgggag cccgaaaaat tggctcggat caaagagctt 1287961 tttgctgcct acagaacggt cgatgaagaa aagctatggg acaatttatc attctttttg 1288021 caggaaattc ttcctgttgc tgaggcctat ggtgttcaaa tggccattca tccggatgac 1288081 ccgccgtggc cgattttcgg actgccgcgc attatcacag gagaggcaag ctataagaaa 1288141 ctgcgggcga tatcagattc accgtctaat tgtatcaccc tttgtacagg ttcaatggga 1288201 gccaatcccg ctaacgacat ggtggagatc gctaaaacgt atgccggcat cgctccattt 1288261 tcacatattc gcaatgtgaa aatttatgag aatggcgatt ttattgaaac atctcattta 1288321 acaaaggatg gttcgatcaa cattcaaggc gtgatggaag aactgcataa gcaggattac 1288381 gaaggatatg tcagaccgga tcatgggcgc catctttggg gcgagcaatg ccgcccggga 1288441 tatggcttat acgatcgggc acttggcatc atgtatttga acgggctgtg ggacgcttat 1288501 gaagcaatgg caaaaaaaga ggtgggcata tgatcccgct gcatgagaac ctggctggta 1288561 aaacggctgt catcactggc ggcagcggcg tgctttgctc tgcgatggcc cgggagctag 1288621 cccgtcatgg catgaaggtg gcgattttga atcggacggc tgaaaaaggc caagcggtcg 1288681 tgaaggagat aacggcggct ggcggcacag cgtgcgctgt tgctgcggat gtgctggaca 1288741 ggatgtcact ggagcgggca aaggaagaca tccttggcca atttggcgct gttgatctgt 1288801 taattaacgg ggctggcggc aatcatcctg acgcgataac cgatgtggag acatatgaag 1288861 aagcgggaga aggccaatcc ttttttgata tggatgagag gggctttcta actgtattct 1288921 ccaccaactt caccggtgcg tttctggcct cgcaagtgtt tggtaaagaa ctgctgaagg 1288981 cggattcacc cgcgatcatc aacctttctt ccatgagtgc ttattcacct atgacgaagg 1289041 ttccggcata cagtgctgcg aaagcatcca tcaataattt tacgatgtgg atggctgttc 1289101 attttgccga aaccgggctg cgggtcaatg cgattgcccc aggcttcttt ctgacaaaac 1289161 aaaatcatga tctgctgatc aaccaagacg gaacgttcac cagccgatct cacaaaatta 1289221 ttgcgggaac accgatgaag cgcttcggaa aaccggagga tttgctcggt acgctccttt 1289281 ggctggcgga tgaatcctat tccggttttg tcactgggat caccgttcct gtcgatggag 1289341 gatttatggc ttattcaggt gtgtaacgaa agcggtgcaa cagaaactga accaacatag 1289401 gggtgaggtt gagatgtttt caaaagataa gcttcccgtt atcctttttt tgttcctggc 1289461 aggggtgatt aattacctgg atcgctcggc gctttccatt gcagctcctt ttattcagga 1289521 tgatctcaca ttgtctgcca cacaaatggg cttgattttc agcagttttt cgataggtta 1289581 tgccattttt aattttcttg ggggcgtggc atccgaccgc tatggggcaa agctgacctt 1289641 gtttgtcgcg atggttgttt ggtcgctgtt tagcggagca gtcgccctcg cttttggctt 1289701 tgtcagcctg ctgattatac gcattctctt cggaatggga gaaggcccgc tttcggcgac 1289761 catcaacaag atggtgaaca actggttccc gccgacccag cgggcgtccg ttatcggtgt 1289821 aaccaacagc ggcacgcccc tcgggggagc catttccggc ccgatagtcg gcatgatcgc 1289881 agtggcgttc agctggaagg tatccttcgt tctcattatg attattggat tgatatgggc 1289941 agtgctctgg ttcaagtttg tcaaagaaaa gccgcaagag acgatcaagg aagcaccggc 1290001 aataaaagca gaaacgtctc ccggagaaaa aattccgctc accttttacc tgaagcaaaa 1290061 aacagtcctg ttcacggcgt tcgctttttt cgcttacaac tacatcctct tcttcttttt 1290121 gacatggttt ccgagctatc ttgtcgacga gcggggatta agtgttgaat cgatgagtgt 1290181 catcacggtc ataccgtgga ttttaggatt tatcgggctg gctgcggggg gatttgtttc 1290241 tgactatgtg tacaaaaaaa cggcccgaaa aggtgtgctg ttctcgcgca aggttgtgct 1290301 tgtcacgtgt ttgttttcat cagctgtcct gattggtttt gccgggcttg tggcaacgac 1290361 tgcgggggct gtcactcttg tcgctctgtc agtgttcttt ctttatttga ccggtgctat 1290421 ctattgggct gtcattcaag atgtggttga tcaaaacaat gtcggttctg ttggcggctt 1290481 catgcatttc ctcgccaaca cggcaggaat tatcggcccg gctttaaccg gatttattgt 1290541 tgaccaaaca ggcacgtttt ctggagcatt tttgcttgcc ggtgggctgg ctgtcttcgc 1290601 ttcacttgct gtgattcgtt ttgtccgtcc aatcattggt aagccagcgg gaacagaagc 1290661 tgagaatcct gtgtcttatt aatctggaaa tatagtggga gaggcggtat gtttgatgat 1290721 acaatataca gtaaataatc gcagccggta tgataaggaa gggaattaga tggtaaccat 1290781 aaaagatatc gcaaaactcg caaacgtatc ccacactact gtttccagag cactcaacaa 1290841 cagcccttac atcaaagaac atacgaagaa aaaaatatta gagctagcag agcagctcaa 1290901 ctatacacca aatgtaaatg cgaaaagtct ggcgatgcaa aagtcgcata cgatcgggct 1290961 attctttaca agcattacaa acggaacctc acacagcttc tttgcagaca ctatcaaagg 1291021 cgtcaatcaa gccataagtg aggattacaa tctgtatgtg cgcggcattg atgatctgaa 1291081 aaactatgac tccgttacac cgatgagata tgacggcatc attttaatga gccaaagtga 1291141 cattgataat tcttttattt accatattcg cgaaaaaaac attccgcttg tcgtgctgaa 1291201 tcgtgatatt gatgatcgta ccatcacgaa tattttgtcc aatgacaagg aaggctctca 1291261 agaagctgta gaatacttca ttcagtccgg acatcaagac atcgccatca tcgaggggat 1291321 cgaaggcttt aaatcctccc agcagcgaaa ggaagggtac ttatccgcac tgattcaaca 1291381 tcatattccg atcaagcatg aatacagtgt caaaggacag tacgatatgg aaagcggctt 1291441 tcaagcgatg gagcggctgc tggcactgcc gaatcctcca accgctgttt tttgttcgaa 1291501 tgatgacatg gcaatcggag cgatgaatgc gatattcgca aagggcctgc gcgttcctga 1291561 tgatatttcg gtgatcgggt ttgatgatat tgggttttca cagtacatca cgccaaggct 1291621 ttcaacagta aagcgcccag tggagaaaat aagcgtgctc ggtgcgcaaa aactcttgtc 1291681 gctgatcagc gagcccgaaa caaaagcaga aaaaatcttg gaaaacacag aatttatggt 1291741 gcgtgattca gtcagacgat tgacgacgtg atgtcccgtt tttcagcggg cattctttat 1291801 acagaaaaat gttaacgtgt gcataaagtg agagggaggc aataagggtg cagaagctga 1291861 ataaaaatgt gtacgatcac tatactcagt atccagaaaa aattctccaa ttcggagaag 1291921 gaaactttct tcggggattt atcgattggc agattgatca attgaatcaa cacactgatt 1291981 ttaatgggag cgtggcagtt gtccagccaa gaggctcaga aaaaatcaaa cgattaaatg 1292041 agcaagatgg attatataca ctttttttac aaggaatgaa agacggagaa gcggtaaacg 1292101 agcatatgat tatcaactca atcagccggg gaattgacct gttttctgat tatgaagcat 1292161 acaaagaatt ggcatcaagc gaaaggcttc ggtttattat ctccaacacc actgaggctg 1292221 ggattgtatg tgatgaaaaa gatcgtttag aggataggcc gcaaaaaaca ttccctggga 1292281 aattaactgc atttctttac tttcgctatc aggcttttaa aggagatcag acaaaagggt 1292341 gtgtcctgat cccatgtgaa ctgatcgaga ataacggtga aaagctgagg gaaacggttc 1292401 ttcattatgc acatctgtgg aagctggagg aaggatttac acagtggatt catgaggcca 1292461 atacattttg taatagttta gtagaccgga ttgttccggg ttttcccgtc gacagcattg 1292521 atgagatcac ggcagatctt ggctatcagg atgatttgat agttgtggga gagcaatatt 1292581 atttgtgggt tatcgagggg cctgattgga ttggaaaaga acttcccttt gcggctgcag 1292641 ggctgcatac aaagatcgtc agcgacctca ccccataccg gactaaaaaa gtaagaattt 1292701 taaatggcgc tcatacagca atgacgccag tggctttatt atacggcttg aagactgtta 1292761 gggatgcagt cgagcatccg gaagtggggc gatttataag agagctgatt gatgacgaaa 1292821 ttcttcctgt tttaaaaatg gaaggtcttt ctcagtatgc tgacgatgtg ctgaaccgtt 1292881 ttaaaaaccc gtatattaag cattacctgg aaagcattgc attgaacgcc atttccaaat 1292941 tcaaaacgag aaacctgccg actcttaagg aatatgctga acaaaaggga cagcttcctg 1293001 aacgcttggt gttttctttc agcgctcttc tgtattttta tcatgataac gagacattgc 1293061 aggatgatcc ggcagttctt caatttttca aagaggtttg gtgtcaggag gatggcgaca 1293121 tgcttcggat tgcatcaaga gtgttaggcg aacagcggct gtggggggca gatctcaatg 1293181 agataccgaa gctgactgat agagtcgctg tttacttgaa tcatattcat gagctgggca 1293241 tgcagagggc tcttgaacaa tactgcatac aagggggaga ggtacgttga agtcgtttat 1293301 aaagattcat aagcaagata atgtccttct tgctctgcgg gatattcaaa agggagagag 1293361 gctgcatgct tacggcgtgt cgattgaagt aaaggatgat ataaaaagag gccataagat 1293421 tgcattgcag tctatcaaag aaaacgacag catcgtcaag tacgggtttc caatcggtca 1293481 tgcatcacaa gatatctcga tcggagagca tattcatgtc cataatacga aaacaaacct 1293541 gtctgatatc caattataca gctatacacc gagatttgat gaaaatccgt attctaatga 1293601 gaaccggacg tttaaaggtt ttagaagaga aaacggagat gcgggtgtac ggaatgaatt 1293661 gtggattgtc ccaactgtcg gctgtgtcaa tggaatagca gaaaaaatgc tgcagcgttt 1293721 tgtcagagaa acaggggata tcgctccatt tgataacgta ctggtgttaa agcatcaata 1293781 cggatgctcg cagcttggcg acgatcatga aaatacgaag cagatcctgc tgaatgccat 1293841 tcgccatcca aatgccggcg gcgtcttggt gttagggctt ggctgtgaaa acaatgagct 1293901 ggcaagaatg aaggaagcac tgcaagatgt gaacttgaag cgggtgaagt ttctggaatc 1293961 ccagtcggtg accgacgaaa tggaggcagg cgttgctttg ctgaaggaaa ttcatgaagc 1294021 ggccaaagga gataagagag aagacattcc gctgtctgaa ctgaagatcg ggctgaaatg 1294081 cggaggttcg gacggttttt ccggcataac cgcaaacccg ctgcttggac gtttttcaga 1294141 ttatctcatt gcacagggag ggagtactgt gctgacggaa gtaccggaaa tgttcggcgc 1294201 agaaaccatc ctgatgcagc gggctgccaa tgaagaagtg tttcataaga tagtcgattt 1294261 aatcaatgat ttcaaacaat actttattaa acatgatcag ccggtgtacg aaaatccttc 1294321 accgggcaac aaagcgggcg gcatttctac acttgaggat aaatcgctgg gctgtacgca 1294381 aaaagcgggg atttctcctg tcacggatgt cttgaaatac ggtgaagtac tcaagacaaa 1294441 agggctgact cttttgagcg caccgggcaa tgatttgatc gcctcctccg cattggcggc 1294501 tgccggctgc caaattgtcc tctttacaac gggaagaggc acgccgtttg gcacctttgt 1294561 cccgacggtg aaagtagcga caaacaccga gctgtatgag gcgaagccgc attggattga 1294621 ttttaacgca ggccttttag cagaggatga tgttcatgag gaatatgtgc tgcgtgagtt 1294681 tatccactat atgattgagg tggcaagcgg ccagcttgtg aaccatgaaa aaaatgattt 1294741 caaagaactc gccattttta aatcgggtgt gacgttataa taagaaaagg ctatccttca 1294801 agcggatagc cttcttcatt aaatcaattt taaaccgctg actaaaataa tggaagccat 1294861 aataaattgc agtggacgcg gggagaatcg aggcgaaaga tggctcccga tcagtacgcc 1294921 gggaattgaa ccgaggagca gattagctgc cagcatgtaa tccacgcttc cgaagcttgc 1294981 gttcaaaatg cctgctgccg taacaagaag aaaagcatgc gcgatatcgg ttccgacaat 1295041 ctgtgacgct ttcatgttaa ataagtaaat catggcgatt gcaaataatg agccggaccc 1295101 gattgatgtt aatccgacga taaacccaaa cacaacacca ataagaattg tcagcgccct 1295161 cttattttca agcggcatca gctgccagcg gttggggcga agttttctat ccaaaaacaa 1295221 acgaacgatg attgaaatgg caaccagcgt taacacatat cctagagcgt gcttaataat 1295281 ttcttcctga tgctggtgaa aggcggggaa caaatgcaat atgccaatgg ctagcgaagc 1295341 actcggaata ctgccgatgg ctaagtattt taccaattta aagttaatcg ttttctgccg 1295401 ccaatgggag gcaacgccaa acagctttgt gatcgagtta tatacaagat ccgtaccgac 1295461 cgcgatggaa ggattaattc caagcacaat taaaagggga gttaataagg ccgctccacc 1295521 cactcccgtc aatccgacta aggctccgac aaacaaaccc atcaatatga tgcttacact 1295581 catgataaag gcctcctgaa aacccgacta gaattcaccc gaatcttatt cgcgttggtc 1295641 aagtattaat tgtaagtgct ccatcggctg ctgaaaaacc cgagctctat ccgctccctg 1295701 atggtatcat tcaattgaca acaccttata catcaggaga acacgtcttt caggtgcaac 1295761 gagcacttgc ggctctgtat ttttaccctg ataaaggcgc tgttaacaac ggaattgacg 1295821 gcgtttacgg accgaaaaca gctgacgcag ttgcccgttt tcagtctgtt aacggtctaa 1295881 ctgctgacgg tatctacggg cctgcgacga aagagaagat cgcagcgcaa ttaagctgat 1295941 caaagaccat aaaaatcccg gagccgctcc gggatttatt ttttcttctt caactttttt 1296001 ataattccag cactgcgctc cctcacccga agcgagtacc cggaaagccc aaaccttccg 1296061 taatcaacaa acttcacacg cctcaccaat tttttcactg tatcacctga cattatcctc 1296121 tgtttgtatt tattatatgt caccctttaa gaaaaggaat aaggacaaga gctgttttcc 1296181 cttgtccttt tagtgtgatc atgctttttt tcgtttatac tcgtcaatca gccgttcgtt 1296241 ttctttgaag attcttgctg tatgcggact gacttgatag cttgcgacac tggtggttga 1296301 acgttttttc aggattttaa acggcttcgc cgctctgggc tcgcatctgt tttgaaacgc 1296361 acgttccatt atccttcacc ttcctcctca attggcagca ccaaatcata tatgctcgtt 1296421 aatgacgtaa atagcaaata atcaaattcc gtgacaatgc tgtcagacgt cagcttgatg 1296481 acatagttct gtgtctcgat ggtaaaaggg atgagaacca cttttccgta ttggtcgtaa 1296541 taaacatcct ttcgatcgag ccgtgtttgt acatctgccg gatcatccat atgctcggtt 1296601 aaccggtctt tatcagcctg tgtcgaatag tggcaaagag aagccgttaa gttcatttta 1296661 tcagcatagg ttttcagcag cttatcaata ccttcagcat aagcatctat acttccataa 1296721 taaacatgga tcggttcgtt tttcaatagg tattggtatg ttttcagccg attgagatac 1296781 atgtggagca tttcgttgtt ttcttcaaga atttctcttg tgtctgtttc aagctcgctg 1296841 ccggccagtt ttttgacata tgcacttaag aagataaaag catcaatcaa agcaaaactg 1296901 actgcgacaa tgagataccg ttcccagtgg gtaaataggg aagtgggctc atatgtccag 1296961 tataccatag cgcccagaac aaacagcaaa taccaagttt tccgaatggc ggacattttt 1297021 tctttgacct tcgcttcgaa acgccacgtg gcatacacgt ataaccccag tccggccacg 1297081 atgcaccaga ccatgatctg aaagaataaa accatattcg aatccctcac atctgaaata 1297141 ggttctgctt attgtattcg agagatccgg atggttttcc tgttccatca aaaaaaccgc 1297201 tcctttgaca gaagcggtgt gacattaaaa tatcatattt aaaataaagt aggcgatggc 1297261 accaagtgtc gctgaaatcg gaagcgtgat gacccatgta atgagcattc gcttggccgt 1297321 accccagttt acgcctttta cgcggtggga cgcaccgacg ccaagaattg atgaagaaat 1297381 gacgtgggtt gtactgaccg gcaaatgaat aaacgtggcg ccgaaaataa tggctgctcc 1297441 ggttaagtca gcggaaacac cgtttaccgg acggattttc atgatctttc cgccaacggt 1297501 tttgatgatt ttccagccgc cgattgatgt tccgagaccc atggctgtcg cgcaggcgaa 1297561 ttgcacccag gtaggaatat cattagcaga agtatgtaaa ttcgctgtga tgagagccat 1297621 tgtgataatt cccattgctt tttgcgcatc gtttgttccg tgtgtatacg attgcagggc 1297681 agctgttaca atctgcactc tgcggaattg cttattcgtt ttcgccaagt tgctgtcttt 1297741 gaaaatcagc ttaacgatgc tataaagaat aaaaccaagg acaaaggcaa taattggtga 1297801 tagaatcagt gcttcaatga ttttaatgaa gcccttatag tttaacgctg caaatccggc 1297861 tgccgcaatg gctgcaccgg caatagcgcc gatgatggca tgggatgagc tgcttgggat 1297921 accgtagtac catgtgataa ggttccaggc aattgcagcg agtagcgcag ccaaaatgac 1297981 aacagagcca ttttccagcg tataaggatc tacgatgtct ttcgtaatgg ttttggcaac 1298041 acctgtaaac gtcattgctc cgacaaagtt catcacagca gccaatataa tggcatggcg 1298101 cggttttaac gcttttgttg ataccgaagt cgcaattgcg tttgccgtat catgaaaccc 1298161 gttgatgaaa tcaaacgcca gagcacaaat gactattagt atcgttaata ttaatagaat 1298221 atccattttt acccctcgtt acgcgttttt cataatgatg gtttcaagat tattggcaac 1298281 actttgacaa gagtcggcga tttcttcaag cgtttcgtat atttcacgat attgaatgac 1298341 tttgattgga tctgtttcat ttccgaaaag attctttaat gattttctgt gcaagttgtc 1298401 acaactgtgc tcatactctt taattttgat tgcgtgaggc tgaatatcct ttaagcgatt 1298461 ttctgccagc agctcgatcg taatcaaaat ctctttcgca cattctctga tatatccgct 1298521 gaatttatca atatgctcgt ctgatgaagt aattgagaaa atctccatca tggcagagaa 1298581 atgttcgatt ccgtcaagca catcatccaa gctgtttgtc agctgaagga tatcttcgcg 1298641 ctcaatagga gtgatgaacg ctttgttaag ctctttaatc atgacatgaa catgattgtc 1298701 accttttgtt tcatattcct ttaacgtatc tgcaaattct ttaagagtcg tttggttagt 1298761 gaccttaaaa ttcacaaaat attctgcagt ttcgtctatg ttctttgcaa tttctgttaa 1298821 aaggagtgag aacttatctt tttttcttct tatcattaaa aaccctccat agtttgaatg 1298881 aacaatgcac acatcaaatt attatatagc cttttgtcga aaaaaaacag gtaaagtcga 1298941 aaaaaacgta tcttgacttt tttgataaat cgtgtctcct tattttgacc tacttcgctt 1299001 taaaaaaacg acccaagttt gcaaaaactt tctgcttaac gtaaaaagta tatcaaaagt 1299061 tgtgtttttc ctgtcaactt ttatcttctg tttcaccaaa aaacggttcc ctaaacaagg 1299121 gaaccgtttt atcagcttgc ttttcgtttt ttcatcccgt aataaacagg cagtccggca 1299181 aggccgatga ggatggataa tccgcagctc attgtatctg taatgagtgt gctgcctaac 1299241 acaaagaagg agcccgcgat tgccagaatt ggcataaatg gataaagcgg aacactgtag 1299301 gcgcgctttt ctccctttgc tcgcttgcgg agaataaaca ctgcaaaaaa ggccatcaca 1299361 taaaaaatgt agatcatgaa aatggagatt tctgagagct tatcagggtt gctgatcagc 1299421 atcataatca aagccaaagc aatttgaaaa gaaatcgcaa tccatggtgt gcggaacgac 1299481 gggtgtacat gtgacagttt ttcagcaaat ggaagctgtt tgcgttccgc cattgcaaat 1299541 gaaacacgcg ggaaagaaag cacctttcca tttaagcacc caaagatgct gacgataatc 1299601 cctacactga tcagctttcc gccaattgaa ccgaacagca tggttgcagc ggtgcttgtc 1299661 gcattttcac caagcgtgac aatttcgttc gctgacagga tgtgaagcaa tgcaaaatta 1299721 atgaaaatat agatcgccgt tacaattaat aatccgcccg tcatagcgcg tggcagcagc 1299781 ttttcgggat ttttcatttc tccgccgaga gcggcaagga gaatccatcc gtcataagca 1299841 aacaacgtag ctaaaatagc cgccccgaag ttcatatcag aaatgctttc gtttactgct 1299901 gtgaagatgt gctgatcgcc tttccaaagg ccaaagacga tgatgcaggc aatcggaatc 1299961 agttttccga tcgttgtcag cgtttggaca aaaccgccgt attttgtacc gataatatta 1300021 atgacgcata aaaagagaac tgctataatt ccaatgactt ttgatagtcc agatccccag 1300081 ccgaaaagat tcgccattaa agatccaaaa tataaaccca gcgcgccaat aatcgccggg 1300141 ccgtaaatga taatctgcac ccagccgcac aaaaatcccc aaaactcgcc gtacacttct 1300201 tcaaggtacg tataaagccc gccggttttt ggaatctgcg ttccgatttc cgcgattgtc 1300261 aaaccgcccg ccagtgttaa aataccgcct aacagccagg cgaaaagcgc catttttgaa 1300321 tcacctgaat aagcaagcac agcgccgggc ttcataaaaa caccagaacc gataatggtt 1300381 ccgatgacaa gagtaagggc aaacaagagg cctatctctt ttttcaaacc gttgtcttca 1300441 gtatgcatgt ccttaacctc ctatgatgtt gaagcttcat gttgaagaat ctattttttc 1300501 atattgtaaa ccctatttta gaaaagtgaa ataaaataaa ttttctgatt ttcgaaattt 1300561 gctttgtgta cagcagataa aactgtagaa atacctgttt taatggtcta taaacgaata 1300621 aaattcataa tttttattta caaagttcgt gttttatgta ttaggatttt agccggtaca 1300681 gaggggagat gagaattcag aaaatgaacg aaccttcggt gaagctgata tgttgacttt 1300741 ctcatgcgaa taaaatactt tgttattaga acaataaata tacaattatg atatgatatc 1300801 tcgaaatcga gataaaataa cctggaggga cagcatatga aagttaacgg cattcaccac 1300861 gtatcggcat taacggccga cgcacaaaaa aacttggatt tctataagaa agtattagga 1300921 ttaaagctcg tcaaaaaatc cgtcaatcag gatgaaccga caatgtacca tctgttctac 1300981 ggagatgaag tggcaaaccc gggaactgag ctgacgtttt tcgagattcc ccgcattgca 1301041 ccgtttcatg cgggaacaaa cagtatttct tctattggat tgcgcgttcc aggcacagaa 1301101 gccctgcatt actggaaaga acgttttgaa gagcagcaag taacgcacag cggcatctcc 1301161 aaaagagccg gacgtgacat attggcattt caagatcatg aggggcagcg acttgtgctg 1301221 actgctgatg aggaaggaaa aggatatggc ctgcctgtta aacagagcgg cattccggaa 1301281 gaattttcgt ttcgcgggtt agggccggtt gaactgactg tgccatatgc tgaaccaact 1301341 ttacacgtat tgacgaatat tcttggattt acagaaatca gccgtgaacc agtcgaaggg 1301401 caaggaaccg ccgttattct ggaatcagga gaaggcggtg ctgcaacgga aatccattta 1301461 atagaaagaa acgatcttcc gcgagagcgt caaggcaaag ggagtgttca ccacgtcgca 1301521 tttcgggtaa gagatgaaga agaacttgcc gggtggcacc ggatcatcag ccgcgaaggc 1301581 tttagcaatt caggcatagt tgagcgctac tatttcaagg cgctgtattt cagagaaccg 1301641 aacggcattt tgttcgagtt atcaacagac ggaccgggct ttatggtaga tgaaaatctt 1301701 gatgagcttg gccaaacgat tgctcttccg ccatatctag agcatcgaag agcagaaatt 1301761 gaagcaaaat tgaaaccgat ccaataaatt gtgattcttt tgccttccgg cgccgccgga 1301821 gggctttttt tattaccata attaattttg acctaaacag catgccttat tagggaggaa 1301881 atatcagatg ctgattggga gaaatggctt aaaacccttt gcaaatatgg gtgattggta 1301941 tggaatggcc tcggcaaaaa tattgtcttt gtttattaat agtttattca tatttgcttg 1302001 ttacactatt tcaaagttag acaaaaagga gtgaaaaata agtggaaaag aaaaaacgcg 1302061 agctggatat cgtcctcctc ctcattttgc tcgcatctgc attcttaaat atctataaca 1302121 tttggaagga cgacacggtg aatccttatt acaccgcggc agttacaagt atgatgcaaa 1302181 gctttcataa tttcttttat gcttcgttcg atgctgccgg ctttataaca gtagataaac 1302241 cgcctgttac ataccaaatc caaacgatca gcgcactgat attcggtatg cacggctgga 1302301 gcgtcatcct gcctcaggca cttgctggtg taggttctgt ccttcttatg tacttgctga 1302361 taaagccgac atttggaaaa acggcggcgc gtattgcctc atttgttatg gcatgtacgc 1302421 cgatagctgt agctgtagca cgtacaaaca atgttgatgc attactggta tttttcttat 1302481 tgcttgctac atggcttctc tttaaagcga tcagaaaagg aaagctgatc tggctgttag 1302541 cagcattttt cgttgttgga gtaggtttta atacaaaaat gctgcaggct tacatgattt 1302601 taccggcttt cttattgttc tatctgattg cggcaaacgc cacaatcaag aaaaaaatcg 1302661 tttcattggt aagtgcgtta gccgtattag cagccgtttc gttatcgtgg ccgctcattg 1302721 ttgacaatat ccctgcaagc aagcggcctt atatcggaag cagccaaacc aactctgttt 1302781 tggaattggc tttcggctat aacggaatcc agcggctgac aggccaaaat tcaggcggcg 1302841 gccagggtgc gccaaacaaa gacgcttcaa aagaaatgtc ttcttctgat aacactcaag 1302901 caccgcctaa tcagtcatca agcaacagct catcaagcga tggtaaatcc tcaaatggca 1302961 atatggcggc gcctccatcc aatggccaaa tgccaagcgg cggtcaagga ggccctccaa 1303021 gcggcggaga tggcggccaa ggcggacccg gcggagacgg agggaaaggc ggtacaggaa 1303081 ccggttcgaa aatgcaatca ggttcaggga tgtttggaac gggaacacct ggtccactgc 1303141 ggcttttcca acaagagtta tctgatcaaa tcagctggct tctgccattt gcgatatttg 1303201 gaatcgcagg cttactgatc gctggcgcaa gagaaagaag aagattatct gtagagcaga 1303261 aggaaacggt gttctgggtt gcgtggcttg taccgattgc cggattcttc agtgtcgcag 1303321 aatttttcca tcattattat ctcatcatgc tggcaccgcc gattgcggct cttgtcggtg 1303381 cggggtgggt cgctcttgtt catctgtacc gcaatcagac aggctggaaa gcatggcttt 1303441 tgccgggagc aattattgcg acaactggat ttgaattgtt tattctcaga aactacaacg 1303501 atcaaatcgg tgttggatgg agtatcgggg taggtgttat cggcgtgttg tcagcgattg 1303561 ctttgctgct gtttaaacag cgccaaaaac cgttcagtta ttatgtttca cttgcagctc 1303621 tcctcgcatt gctggtgatg ccgatgtatt gggcaagtac accgcttctg tacggaggca 1303681 acagctcact gcctgaaaca ggccctcaac tcgcatcaat gagcggaaaa ggcatgggaa 1303741 tgtctgatgc gactgtaaat gaaaaactga tcaaatatct agaggagaat aactccggag 1303801 ctgaatacct attcgccaca accgattcga acacagcggc accatatatc attaaaacga 1303861 aaaaagctgt catggctatt ggtggataca gcggttctga cccggcaatc acactgactc 1303921 aattcaaaaa acttgtaaaa gaaggaaaag tgaaatactt cttggcttct ggaatgggaa 1303981 gaggcggaaa caatgacatt gttgaatggg ttgagaaaaa tggaaaagaa gtagcatcag 1304041 aaaaatggca atcaagttct gatcaaaaaa cagaaaatac tgattcagct gatacatcaa 1304101 gcagcaaggc ttcaggtgaa aacggcaaaa tgggcggacc tggcggaatg aatcagtcag 1304161 caacattata cgaactacat gctgatgaat aggaggcaaa aacatgagca gacatattca 1304221 atattcaatt gttgtacctg tgtataatga agagcttgtc attcatgaaa cctatcagcg 1304281 cttaaaagag gtcatggatc aaacgaagga aaactacgag ctgctttttg tcaacgatgg 1304341 cagcaaagac cgcagtattg agattttaag agagcacagc ctgatcgatc cgagagtgaa 1304401 aattattgat ttttcaagga attttggaca tcagatcgcc attacggcag gtatggatta 1304461 tgcacagggg aatgcaatcg tcgtcattga cgccgatttg caggaccctc ctgaactgat 1304521 tttagaaatg attgaaaagt ggaaggaagg ctatgaagtc gtgtacgccg tacggactaa 1304581 acgaaaaggg gaaacctttt tcaaaaaaca aaccgcggct atgttttacc ggcttctcag 1304641 cggtatgaca gatattgata tcccgattga tacgggggat tttcgcctca tggacagaaa 1304701 agtctgtgat gaaatgaaga gattaaaaga aaaaaatcca tttgtaagag ggctagtcag 1304761 ctgggtgggt ttcaaacaga cagcggtcga gtatgtacgt gatgaaaggc tcgccggaga 1304821 aacaaagtac ccgctcaaga aaatgctgaa gctgtcaatg gacggcatca cgacattttc 1304881 acataaaccg ctgaagctgg caagctatgc ggggatttta atgtcaggta ctggatttct 1304941 gtatatgttt atcgtgctgt atctgaagct attcacagac agcacgatta ccggctggtc 1305001 atcacttatt gtgatccagc tcctgttcag cggcattgtc cttctgattt tgggcgtgat 1305061 tggcgaatat atcggcagaa tctacgatga agccaaagac aggccgcttt acatcgtcca 1305121 aaaatcgtat ggaattgaaa ataaaagact ctatagagac cagcatatgt cataacctca 1305181 aaccccctgt ccgtaatgga cagggggttt ttatgctctg agcacgatct aaagcaaaag 1305241 atgctgatag atatatggaa attgggtaaa gaagagattg tgagcttgta ctgcggttca 1305301 gtcatgctga aataaaaaca gcaaaactta aagatttcgt cctcggcttt gctgcatgtc 1305361 agctgttata ttggggggct tttaagaaac gcatgattag agccgtacca gttatgttta 1305421 atagaatact cgtacccaat acaattcccc acgtcaacgt cgattcagag agaagaaagc 1305481 tcagcaaaag aaaagccaat cctgcgcaga tcatacccag tcccacggtt ttcatgttca 1305541 tgcctcctag caaacgatgt ttctagcatc tgatgtgaat gatgtcaatc tgtatgatat 1305601 acggatatct cgtcagaaag tttcatagaa caattaggtc ttttatctaa taaaaagcct 1305661 cagaccgctt ttacggcctg aggcattatg tcttacgaag ttttctcttc tttttgatcc 1305721 agtttaattt ttttcgtcat ttctttgccg tttcggagaa ttttcacttc aacggtatca 1305781 ccgatctttg cgtctttata taagatattg cgcaattcac tgcctgtatc aatttcttta 1305841 ccttttaggc cgatgataat atcctccgct tttaatccgg ccttttcagc aggagagcct 1305901 gaagcgacct cacggatgta aacgccttta ttcagctggc tgccgaacag gccgagtgtg 1305961 ccttcttggt aattttgcgg cacttgctct agatcaagca tgctgacacc gatatatgga 1306021 cgttcaattt gtcctttaga cagcaattct tcagcaatcg gttttacgtc attgcttgga 1306081 atggcgaatc cgataccctc aacatcatcc tcactgattt tcatactgtt aatgccgaca 1306141 attttgccgt ctgtatttaa caaaggaccg ccgctgttac ctggattaat tgctgcgtct 1306201 gtctgaatga cgttaatgct cgtttcgccg gctgatgtag acattgaaac cgttctgtcc 1306261 acgccgctta caattccttg tgttactgtg cgggacaggt cttttccaag cggatcccca 1306321 atcgcaataa cggtctcgcc tgttctaaga tcagatgaat caccgaagtt tgccactttt 1306381 gtgacgtggt catcactgat ttggaggacg gctaaatcag ttaacgagtc actgcctacc 1306441 agctttgcag taacctcagt gccgtcatat aaagatacct tcagtgatga tgccccttct 1306501 acgacgtggt tatttgtaat gatataagcc ttgccattct cttttttgaa aatgacacct 1306561 gaccctgaac cgctttctgt atcttcgctg gaatcagaag aactagagcc gaacaaagag 1306621 ctgtttgatt gtgcctgaag atttgtaata ccgacaatcg ctggtgaaag gtcttctacc 1306681 atatctgaga ttttagaaga gtcctcgctc ttgaatgcag atgagctgct tgagcttttt 1306741 ttagattcag aggaggtgct tgttgctgta acagattgcg tttgctgctg gctggatgat 1306801 tgttttgcag tgtcctgaga atcatggtca ccaagcggtg taaacgtgta aatgccaaga 1306861 gcaagactgc cgccgatcac tccgccaagc aacggtctga accatccgaa tcctcgtttt 1306921 ttcttctcct gatcatgaat gacattgcgg gccgagtagg aggcgctctg atcgttctct 1306981 ttcgttaaaa agacctcatt ctcattacct ttcgttctgt tttcatcacg atagttatcc 1307041 atcatgttca ctccgtttct ctattttcac atgtctattt atattgatag gtttatgact 1307101 tgagtttatc ataaacaaaa actgtgggat aaaaatgaaa agattatggg aaattgtgaa 1307161 aaagtgcgga aaacggtaca cttcatattg tatatgaaag gactgagtcg atggaacaga 1307221 ttggattgat tggatatggc agcatggcgg atatgatcgc tagacagctg ttgaaacatg 1307281 aacaaataaa agagaatgag ctatttattg agacgagaac gaagggggag cggctgcggg 1307341 cactcatgtc agattatcca aacgtatcgg ctgatccgtt ggagaattgg gcaaatacgt 1307401 gccaattgat tttgatatgc gtcccgccac tccatgtcat cgaaacaatg cgccgtctgt 1307461 acccgtatgt gaacagaaat actcacatcg tatccatagc tgccggtgtg ccgctgcgtc 1307521 ttttggaggc agaaacagaa gccggtatct cacgtgttat tcctgccatt acgtccgaag 1307581 cagaagccgg catctcactt gtcgttcaca gtgaagcact ggctgcagag aaaaaagaac 1307641 gtctgaatga attgttatcg gttttcagcc gtgtacggga aatcaaagaa tcgaatttag 1307701 atgtggccag caatttaacg agctcggcac cgggattcat agctgcaatc tttgaagaac 1307761 tggcactgtc tgccgtcaga aacagcagcc tgtccaaaga agaagccttt gattttctga 1307821 ttcattcgct atacggaact ggcaagatgc tgatcgaaaa aaatatgtct ttcgaggaga 1307881 cgctggaacg tgttgcaacc aaaggcggaa taacgggaga gggagctgag gtgatacacg 1307941 cctctgtgcc ggacgttttt gatgaggtat ttgaaagaac cctgagaaaa tatgaactgc 1308001 ttacagaaca ggttggtaaa caaacatgaa tccttgaaag aggattcttt ttttatcact 1308061 gaatgattga gatttttccc agttatattg catttttcct ctttttttaa tataatttgt 1308121 tagaatattc ataatttagt aaaaaaggag gagcgttatg aaattgtaca tgtcagtaga 1308181 tatggaaggt atttcgggtc ttccggacga tacctttgtg gattccggca agcggaatta 1308241 tgaacgcgga cggcttatca tgactgaaga agcaaactac tgtattgctg aagcgtttaa 1308301 cagcgggtgt accgaggtgc tggtcaatga cagtcattcg aagatgaata atctgatggt 1308361 tgaaaagctt caccctgaag cagacttgat ttctggtgac gtcaaaccat tttcaatggt 1308421 ggagggactg gatgatacgt ttagaggcgc tttgtttctc ggttatcatg cgagagcctc 1308481 gactcctggt gtcatgtcac acagcatgat tttcggcgtc cgtcattttt acataaacga 1308541 tcggcctgtc ggtgagcttg gattaaatgc atacgttgcc ggttattatg atgtcccggt 1308601 attaatggta gccggggatg accgggcggc gaaggaagca gaagagctta tcccgaacgt 1308661 gacgacagcc gcagtcaaac aaaccatttc aagatccgca gtgaagtgct tgtcgcctgc 1308721 gaaagccgga cggctgttga cagaaaaaac cgcatttgcc ctgcaaaaca aggacaaagt 1308781 caagccgctc acaccgcctg acaggccagt tctgagcatt gaattcgcca attatggcca 1308841 agcagaatgg gcgaatctga tgccgggaac ggaaatcaag acgggaacta caaccgttca 1308901 atttcaggcg aaggacatgc ttgaagccta tcaggcgatg cttgtcatga ctgagcttgc 1308961 gatgcggaca tcattctgct aaaggggtgt tttaggcttt ggcgcgatac atgataaagc 1309021 gtttttgggc aatggcagct acgattttgg tgattaccac cctgactttt gttctcatga 1309081 aggtcattcc cggatctcct tttaacgagg agagaggcac aaatgaagcc gttcaaaaaa 1309141 atctcgaagc ctactatcac ttagacgatc ctctcatttt ccaatacatt ttctacttaa 1309201 aatccatcat tacattcgat ttcggacctt caattaaaaa accgtcggac agcgtaaatg 1309261 atatgctgga acgcggattt cccgtttcct ttgagcttgg gatgacagcg attgtcattg 1309321 ctgtgatttc tgggctggtg ctgggcgtaa tcgctgcact ccgccgcaat ggctttttgg 1309381 actacgccgc gatgagtctt gcagtactcg gcatctccat cccgaatttt attctggcaa 1309441 cattgctcat tcagcaattt gctgtcaatc tcaaactatt tcccgctgcg acatggacga 1309501 gcccgattca tatggtgctt ccgaccgcag cgcttgctgt agggccaatg gcgatcattg 1309561 ccaggctgac acggtcgagc atggtcgaag ttctgacaca ggattatatc cgcacagcaa 1309621 aagcaaaagg gctttctccg ttcaaaatta tcgtaaaaca cgcactcaga aatgcactca 1309681 tgcccgtcat taccgtcctg ggcacactcg tcgccagcat cttaacagga agctttgtca 1309741 ttgaaaaaat ctttgccatt ccgggaatgg gaaaatattt tgttgaaagc attaatcagc 1309801 gggactaccc cgtgattatg ggaacgaccg ttttttacag cgtcattctg attatcatgc 1309861 tgtttttggt cgatttggcc tacggtctct tagacccgcg cattaaactg cataagaaag 1309921 ggtgaagcgt gtgaatctcc ctgtacaaac ggatgaacgc cagccagaac agcacaatca 1309981 ggtgcctgat gagtggtttg tcttgaatca ggaaaaaaat cgggaagccg attcggtcaa 1310041 gcggccgagt ttgtcataca cgcaggatgc ctggaggagg ctgaaaaaaa ataaattagc 1310101 gatggccgga ctctttattc ttttatttct ttttgtcatg gcagttatcg ggcccttttt 1310161 atcgccccat agtgtcgtac gccaatcgct gacagaacaa aatcttccgc cctcagccga 1310221 tcattggttc ggcaccgatg aactcggccg ggatgtgttt acccgaacat ggtatggcgc 1310281 gagaatctcg ttgtttgtcg gcgtgatggc agcactgatt gattttttga tcggtgtcat 1310341 ttacggaggc gttgccggct ataaaggcgg caggattgac agcattatga tgcggattat 1310401 cgaagtgctg tacggactgc cgtatctgct tgttgtcatt ttgctgatgg tgctcatggg 1310461 accgggactg ggcacgatta ttgtggcgct gactgtgacc gggtgggtcg gcatggcgag 1310521 aattgtaaga ggccaggtgc ttcagattaa aaattatgaa tatgtactcg cctcgaaaac 1310581 ctttggcgcg aaaacctttc gcatcatccg gaagaatttg ctgccgaata ctatgggagc 1310641 gatcatcgta caaatgacat taaccgtacc tgccgccata ttcgcagaat catttttaag 1310701 ctttctcggc ctgggcatac aggctccgtt tgcaagttgg ggcgtgatgg cgaatgacgg 1310761 cctgcctacg attttatctg ggcattggtg gcgcctgttt tttccggcct ttttcatatc 1310821 tctgacgatg tacgcgttta atgtgctggg ggacggattg caggatgcgc ttgaccctaa 1310881 gctgaggagg tagctgtatg gaaaaagttc tgtcagtcca aaatctgcac gtgtctttta 1310941 cgacttacgg cgggacggtt caggcggtca gaggggtgag ctttgatttg tataaaggag 1311001 aaacctttgc gatcgtcggc gaatccggct gcggcaaaag cgttacctcc caaagcatca 1311061 tgggcctgct tccgccttat tcggcgaagg tgacagacgg caggattcta tttaaaaaca 1311121 aagacctttg ccgtctctct gacaaagaaa tgagaggtat aaggggagcc gacatttcta 1311181 tgatttttca agacccgatg acggcgttaa accctacgct gactgtcggc gaccagctgg 1311241 gggaagcgct attgcgccac aaaaaaatga gcaaaaaagc ggcacggaaa gaggtgcttt 1311301 ccatgctgtc attggttggt attccagatc ccggagagcg cctaaagcaa tatccccacc 1311361 aattcagcgg cggtatgaga cagcggattg tcattgcgat ggcgctgatt tgcgagcctg 1311421 atatcttaat tgcggatgaa ccgaccaccg ccctggatgt aaccattcag gcacagattt 1311481 tagagctgtt taaagagatt cagagaaaaa cggatgtgtc tgtcattctg attacgcacg 1311541 atttaggggt tgttgcccag gtagctgaca gagtcgcagt catgtatgcc gggaaaatgg 1311601 cggaaatcgg cacaagaaaa gatatttttt atcagccgca gcacccatat acaaaaggcc 1311661 tgctgggctc tgtcccgcgg ctggatttaa atggcgctga gctgaccccg attgacggaa 1311721 cgccgccgga tttattttcg cctccgccgg gctgcccgtt tgccgcccgc tgtccgaaca 1311781 ggatggttgt gtgtgacagg gtgtacccgg gccagacgat cagatctgac tcgcacaccg 1311841 tcaactgctg gctgcaggat caacgagcag agcatgcggt gctgtcagga gatgcgaagg 1311901 attgaacatg aaaaggggga agaggatgaa acgagtgaaa aagctatggg gcatgggtct 1311961 tgcattagga ctttcgtttg cgctgatggg gtgcacagca aatgaacagg ccggaaaaga 1312021 aggcagtcat gataaggcaa aaaccagcgg agaaaaggtg ctgtatgtaa ataatgaaaa 1312081 tgaaccgact tcattcgatc cgccgatcgg ctttaataat gtgtcatggc agccgttaaa 1312141 taacatcatg gaggggctga cgcgtcttgg caaagatcat gagcccgagc cggcaatggc 1312201 ggagaaatgg tctgtttcga aagataataa aacttacaca tttacgattc gggaaaatgc 1312261 gaaatggaca aacggagatc ctgtaacagc cggagacttc gaatacgcgt ggaagcggat 1312321 gcttgatccg aaaaaaggcg cttcatcggc attcctaggt tattttattg aaggcggcga 1312381 agcatataac agcgggaaag ggaaaaaaga cgatgtgaag gtgacggcaa aggatgatcg 1312441 aacccttgaa gttacactgg aagcaccgca aaaatatttc ctgagcgttg tgtccaatcc 1312501 cgcgtatttc ccggtaaatg aaaaggtcga taaagacaat ccaaagtggt ttgctgagtc 1312561 ggatacattt gtcggaaacg gcccgtttaa gctgacggaa tggaagcatg atgacagcat 1312621 cacaatggag aaaagcgaca cgtattggga taaggataca gtgaagcttg ataaggtgaa 1312681 atgggcgatg gtcagtgaca gaaatacaga ttaccagatg tttcaatcag gggaacttga 1312741 taccgcttat gtccctgctg agctgagtga tcagctgctt gatcaggata acgtcaatat 1312801 tgttgaccag gcgggtctct atttctatcg atttaatgtc aacatggagc cgttccaaaa 1312861 tgaaaacatc agaaaagcct ttgcgatggc tgtggatcaa gaggaaattg taaagtacgt 1312921 cacgaaaaat aatgaaaaac cggcgcacgc ctttgtatcg cctgggttta cgcagcctga 1312981 cggcaaagat ttccgtgaag caggcggaga cctgatcaag cctaacgaaa gcaaagcgaa 1313041 gcagctgctc gaaaagggca tgaaggaaga aaactataat aagcttcctg cgatcacgct 1313101 tacttacagc acaaagccgg agcataaaaa gattgccgaa gctattcagc aaaaattgaa 1313161 aaatagcctt ggagtcgatg tgaagctggc caatatggaa tggaacgtat ttttagagga 1313221 tcaaaaagcg ctgaaattcc aattctctca aagctcattt ttgcctgatt atgcagaccc 1313281 tatcagtttt ctggaagcct ttcaaacggg aaattcgatg aaccgcacag gctgggccaa 1313341 taaagaatac gatcagctga tcaaacaggc gaaaaacgaa gccgatgaaa aaacacggtt 1313401 ctctcttatg catcaagctg aagagctgct catcaatgaa gcgccgatca ttccggttta 1313461 tttttataat caggttcacc tgcaaaatga acaagtaaaa ggaattgtcc gtcaccctgt 1313521 cggctatatc gatttaaaat gggcagataa aaactgatgg aggcgattga ggaaatactg 1313581 cttctttatg cgaaggagcg gtattttttc tctttcttgc acgtatacgt agggtgcaga 1313641 gcaaatgaaa ggagtgtttt cgttgaatta caagccgaaa gcgttgaaca agggtgatac 1313701 agtcggagtg atcgcgcccg caagtccgcc ggatccaaaa aagcttgaca ccgcgctttt 1313761 atttttagaa gagctcggtc ttcaggtgaa gttgggcaag gcgctgaaaa accagcacgg 1313821 ctatttagcg ggacaggatg atgagcggct ggcggatctc catgagatgt tcagagacga 1313881 tgaggtaaaa gcagtgttgt gcgcatgcgg gggttttggg acaggacgta tcgccgcggg 1313941 cattgatttc agcttgatcc gcaaacaccc taaaatcttt tggggataca gcgatattac 1314001 gtttttacat actgccattc atcaaaacac aggtcttgtc actttccatg gcccgatgct 1314061 cagcacggat attggccttg acgacgttca cccgctgaca aaagcgtcat ataagcagct 1314121 cttccaggag acggaattca cctatacaga agagctttct ccgctgaccg agcttgttcc 1314181 tggaaaagcg gaaggcgagc ttgtcggggg aaatctgtct ttgctgacgt ctacactggg 1314241 cacgccattt gaaattgata cgagaggaaa gcttctgttt attgaagata ttgacgagga 1314301 gccttatcaa atcgaccgga tgctgaatca gctgaaaatg ggggggaagc tgacggacgc 1314361 ggcgggaatt ctagtttgtg attttcacaa ttgtgtcccg gtgaagcgag agaagtctct 1314421 ctcgcttgag caggtgctgg aagactatat tatttctgcg ggcaggcctg ctctgagagg 1314481 atttaaaatc ggccactgct cgccaagtat tgccgttccg atcggtgcga aagctgctat 1314541 gaatacagca gaaaaaacag ccgtaataga ggcgggcgtt tcagaagggg cgctgaagac 1314601 atgaaaatca ttcgaatcga aacaagccga atcgctgtcc cgctgacaaa gccgtttaaa 1314661 accgcacttc gcactgtgta tacggctgaa tcagtcatag taaggattac ttatgacagc 1314721 ggtgcagtcg gatggggaga agcacccccg acgttagtga ttacaggaga cagcatggat 1314781 agcattgaaa gtgccatcca ccatgtgttg aagccggcat tgcttggaaa aagcctggcg 1314841 ggctatgagg ccattctgca cgacatccag catcttctta caggaaatat gagcgcgaag 1314901 gctgctgtag aaatggctct atacgacggc tgggcgcaga tgtgcgggct gccgctttat 1314961 caaatgcttg gcggatatcg agatacgctg gaaacagatt atactgtcag tgtcaactca 1315021 cctgaagaga tggcagctga tgccgagaat tatctcaaac aaggctttca aacgctgaaa 1315081 ataaaggtcg gaaaagatga tattgcaaca gatatcgccc gtatccagga aatcagaaaa 1315141 cgtgtcggat cagctgtgaa actgcgttta gacgctaatc aggggtggag gccgaaggaa 1315201 gcggtaactg ccattcggaa aatggaggat gcgggcctag gcattgagct tgtcgagcag 1315261 cctgtccata aagatgatct cgctgggctt aaaaaggtga cagatgcaac agatacgccg 1315321 attatggctg atgaaagtgt ttttacaccg cgccaggcgt tcgaagttct gcaaacccgg 1315381 agcgcagact tgatcaatat taaattgatg aaagcgggcg gcatcagcgg agcagagaaa 1315441 attaatgcca tggcggaggc ctgcggggtg gagtgtatgg tcggcagcat gatcgaaacg 1315501 aagctgggca ttacggccgc ggcgcatttt gcggcaagca agagaaacat cacacgcttt 1315561 gattttgacg cgccgctgat gctgaaaaca gatgtattca atggcggcat aacatatagc 1315621 ggcagcacga tttcgatgcc tggcaaaccg ggcctcggaa tcatcggggc tgcgcttttg 1315681 aaaggggaaa aagagcaatg atgcacactg tcatatcagc agtggccaac atctggacag 1315741 cgcctgattc acctcgtccg tctgatcaat tcatgcttca accgactgta atgatcagag 1315801 actggctgga gcgcatgacg tatgatgaac ggcttggatt atgtacagac aatgtaatcc 1315861 aaactcaggt tctctttggc gaaaaggtac ttgtgacggc ggaacagggg gaatgggttt 1315921 ctgtgatcgt gcctagccag ccatcccgaa aggatccgcg cggatacccg ggctggatga 1315981 aaaagtacca gctggaaaaa acaaagccca tccatacaca acacgatgtg atgatcagca 1316041 aacctgctgc ctttttgtac agaagcaatg gggaaaagga gatcgaatta agctttttga 1316101 cagttctgcc ccttattgca aaagaaaacg gatattttaa ggtttcgacc gtttttgggg 1316161 aaaggtttgt gaggcaaagt gatgcagtgc ctgtcagcca acagaaaggg actgctgaag 1316221 acatcattca aacgggtgcg ttttttcttg gccttcccta cctgtgggga gggatcagcg 1316281 ggtttgggtt tgattgctcc ggatttatgt acagtatatt taaggcgaat ggatacagca 1316341 tcccccgtga tgcgggagat caggctaagg cagggaaggg tgtcccgctt gatgatatga 1316401 aagccggtga tctgctgttt tttgcttatg aggaaggaaa aggagcgatt catcacgtcg 1316461 gtctgtatgt aggcggcggg aaaatgcttc attctccaaa gacagggaag tcaatcgaaa 1316521 tcctcacatt aacagagaca atctatgaaa aagaattatg tgcggtgcgc cgctgttttt 1316581 cagaataagg agggagacaa atgaggcgac tgcctttgtt agaggtcagc cagctgaaaa 1316641 tgcattttga cgcagggaaa aagcggacag tcaaagctgt cgacggggtc acctttcaga 1316701 ttcgtgaagg agaaacgttc gggctagtcg gggaatcagg gtgcgggaaa tcaaccttgg 1316761 ggagagtgct gatgcgcctt tatcagccga cagaaggaag cgtgacatac cgcggcacaa 1316821 atcttcatgc actaagtgaa aaagagcagt ttgccttcaa ccgcaaactg cagatgattt 1316881 ttcaggaccc ttatgcttca cttaacccgc gcatgaccgt tcgagaaatt attttggagc 1316941 cgatggagat tcataatctc tacaataccc ataaagcacg gcttctcgtc gtggacgagc 1317001 tgcttgaggc agttgggctt caccccgatt ttggcagccg ttatccgcat gaattcagcg 1317061 gcgggcaaag gcagagaatc gggattgcga gagcactgtc gctgaatcct gaatttatcg 1317121 tggcggacga accgatttct gcacttgatg tctctgttca agcgcaggtg gtcaacctgc 1317181 tgaagcggct tcaaaaagag aaagggctta cgtttttatt cattgcccat gatctttcga 1317241 tggtgaagca tatcagtgac aggatcggtg ttatgtactt aggacacatg atggaaatta 1317301 cagagagcgg caccttgtat cgtgaaccgc tccatcccta tacaaaggcg cttttgtcct 1317361 cgattccgat tccagatcct gaattggagg acaagcgtga gcgtattctc ttgaaagggg 1317421 agctgccgag cccggtcaat ccgccaagcg gctgcgtgtt tcgtacccgc tgtccggagg 1317481 cgatgcctga atgtggagaa tctcgtcccc agcttcaaga aatcgaaccc ggccgttttg 1317541 tcgcttgcca tttgtatcga aatgctgaaa cgaaggaaaa agtaagataa ataaaaagag 1317601 tggctccttt ttactagagc cactccattt gtttatactt gatgtaaaaa ctttacacaa 1317661 accgggtaag ggacagaaac cgttgatggg aggagtgtca atcggccggt ttctttgtct 1317721 ctttcaaaca agacaaggtt gcctgtttct tcatttgaag caacgaggaa cccttccgtt 1317781 gggtcaaata caaagtcacg aggccagttt ccttctgtcg acactctttc tacgaaagcc 1317841 agctctcctg aatattgatt cacttcaaat acggcgatac tgtcatggcc gcggtttgcg 1317901 acataaacaa aacgtccgtc ctgcgtgaca tgtattgcgc ttccctggct gttatctgta 1317961 aaatcatcag ggatggcaga aacgacttgg atttctctaa attcgccggc tgtcgggttg 1318021 tattcaagcg caatcacttc attgcttaat tctgtcatga cataagcgta tttttctttc 1318081 ggatgaaaag cgatatggcg aggtcctgca ccgggagcga aggaatggct tccggattca 1318141 gtcaacacac cgtctttaag cttataggtg tagagcttat ctatacctaa atcaaccgct 1318201 accacataat tgtgttcagg tgtgaacccc gcgtagtgtg tatgcggttt ttcttgtctt 1318261 tcgtgcggcc cttttcctgt gtgagcggcc tctgaaacag gtgattgcaa gctgccgtct 1318321 tcctgaaccg gaaaaacgtg taccttcccg ctgtgataat tggcagtcag tacgaattga 1318381 ttttgatcat caacgcttac gtggcatggc gaagggccat caattaactg atgattcaga 1318441 aatgtcaatt cgccgctgtt tttatcgatt tgataggcag caactccgcc ttggccgtct 1318501 gctttttcga tggaataaag gatggtgttg tttttattcg tcgccacata tgtcgggttg 1318561 cccagcttag cggccagctt tggctcgctg agtgcttttt tctcagtatc aagctcaaat 1318621 gaataaattc cttcgcttcc gccttttgta tatgttccca catatcctat gtattttgtc 1318681 atgcgatttc ccccttaaaa atgatgtcac ctctatatta acgtatcttg ataaaataag 1318741 ctgttcaaaa catgaaaaag gggaagattc ttcattcgcc tcgaatcagc ggcattgtgc 1318801 agcacctgaa ggagccgcct gatttaataa tttctgacag gtcaatttcg ataatgtgat 1318861 agcctctttt cgatagctgt tgattgacat ggcggttgcc agggagactg atgatcgttt 1318921 tttttccgat tgaaaggacg ttggtgccaa gcgtaaattg ttcgtcctcg ggcacctcaa 1318981 taagatcata acgttttgcc agcatatcgg ctgcatctgg ctcaatggcc tgtgaataaa 1319041 ttaacgcttc gctttcagat ataatgttaa atacgcagtc caaatgcaaa aatttttcat 1319101 gaagcttcac tggaacgatc gtatattcag gaagtgcctc ttctagctgg ccgatagctg 1319161 aaatgtcggt gcgctggctg attccgacat agacaatgtc atcatcgata atgacgtctc 1319221 cgccttcaat actcgtatca agcatgcggg tgtaagagat accttggctg tgaaaaaaat 1319281 cttttataac ggcttcttct ccttggcgaa tcggttcagt catgcttgac agaaaggctt 1319341 tttctccgat gacaaatcct atgtccctag taaaaacctg ttctgggagt ccgtcgcgaa 1319401 cgggcaaaag gacgacctca acgttgtgtg acctaagtgc ctccactaag cggctgtgct 1319461 ggtcgttagc ggtttttaca tgaatattgt catcttcaaa atgtttttgt gtttcgttta 1319521 taacatcttt tatggtcatg tgctcaggtt tgcataagat cactttttga agtgtgccgt 1319581 attccgttcg gcataccgtt ttgtgctgag atttcgggat ggatacgtcc atttgttttt 1319641 cctcctaaag tgtgaagaat acatttatta ttccctcatc atgaaaatca ttaaaccatt 1319701 ttaaatttta gacaaatgga agagaatatt gtttaatagg agaatataag tgcatttagc 1319761 taaaagatca gacatcaaag gggagaaagg tatggaaaca ccggaaacaa gattttgtaa 1319821 agagtcaaag gttgtgaaaa ccagcagggt gttcccgctt gacacgaaca accataatac 1319881 gctgtttggc ggaaaattaa tgagctacat agacgacatt gcctctattt cagcggcgcg 1319941 ccattgcaga cgtgaaacgg taacagcttc aatggattct gtagattttt taaagccgat 1320001 cgggcaaaag gattctgtct gcctagagtc atatgtgaca tgggtcggca catcttccat 1320061 ggaagtattt gtgaaagtta ttaaggagca tttgatgact ggcgaacggg aactcgctgc 1320121 cacatccttt ttgacatttg tcgcattaga ttcaaatggc aagccggtgc ctgtaccgag 1320181 ggttgtaccg gaaacagaag aagaaatcat gctgcataat acagctgtac agcgtgctaa 1320241 tgaacgtaag aaccgcaaga gacacagcca ggcgcttgca aatgcgctcg gaactgataa 1320301 gccttggtga acgttaaacc caaaacataa gttgttttgg gtttttttgt acttttcaat 1320361 ggtgattatt acaatggtta gtccgttttt gctaggggat tctataaaaa agcaacaaat 1320421 gtcatgttaa attgataatt ttgtgacaac tttattaaag attcatttta gatatatctt 1320481 ttattcgtaa gatcatgtat tttaaagata tattttaaat acatcttttc gaaaggattg 1320541 tttataaaat gttagataac aaaacaatcg aaattattaa aagcactgta cccgtattgc 1320601 aacagcatgg agaaacaatc actggccgtt tttacgatcg gatgtttcaa gaccatccag 1320661 agcttttgaa catttttaat caaacaaacc aaaagaaaaa aacacagcga actgcactgg 1320721 caaatgccgt tattgcagct gcggcaaaca ttgaccaatt aggaaacatc attccggttg 1320781 tcaaacaaat cggccacaag caccgcagta tcggaattaa gcctgagcac tacccaatcg 1320841 tcggtaaata tttgctgatt gcgattaaag atgtattggg agacgctgca actcctgaca 1320901 ttatgcaggc atgggaaaaa gcgtacggag tcattgctga cgcgttcatc ggaattgaaa 1320961 aagacatgta tgaacaggct gaagagcaag ccggcggctg gaaggagtat aagccattcg 1321021 ttatcgcaaa aaaagagcgg gaaagcaaag aaattacatc cttctatttg aaaccggaag 1321081 acagcaagcc gttacctgaa ttccaagcag ggcaatatat cagcatcaaa gtgcggattc 1321141 ctgattctga atatacgcat atccgccagt acagcctgtc tgatatgccg ggaaaagact 1321201 attatcgaat ttcagtgaag aaagatggtg tcgtgtcttc ctacttacac gatgggctgc 1321261 aggagggaga ttcaatagag atcagcgcac cggcagggga ctttgtttta gatcatgcat 1321321 cacaaaaaga tctcgttttg atcagtgccg gagttggcat tacaccaatg atcagcatgc 1321381 tgaaaacatc tgtttccaaa cagcctgaac ggcaaattct gttcattcat gcggcgaaaa 1321441 acagtgaata tcatgcattg cgccatgaag tagaagaagc agcaaaacat tctgctgtta 1321501 aaacagcatt tgtgtatcgc gagccgacag aggaagaccg tgcaggtgat ctgcattttc 1321561 atgaaggaca gattgatcag caattcctca aagaactgat tgccaacaca gatgcggatt 1321621 actatatttg cggttcaccg tcgtttatta cggcaatgca taagcttgta tcagagctcg 1321681 gatcagcgcc ggagtctatc cattacgagc tattcggccc gcaattaagt ttggcgcagt 1321741 ccgtttgaac acatacatga aactcttctc ctttcagaga agagtttttt attgagatat 1321801 aagaaggcag acaagcgccg gtttctacat ccggacaatc acagacccgc tgccatttgt 1321861 gcatacacgg ttttgctgtt cttgcattgt tctcagcaat tcattgttta cctcaatcgc 1321921 tctaattagt tgcttcattc ttagctccaa accggccagc ctgtcgattg tttgctgctg 1321981 gtagccctcg ggttggggag ccaatggcag atcaaagggc caaagggtat tcgacttctg 1322041 atttttcata ttgcgtattg cgcctccaat cggtgtcact ttctattatg ttatgttcag 1322101 gcgatatgca cgttcgccta gacactgatg catagagggc ctgccacggg gcacaatagg 1322161 ctcaatatga ccagcggatg gaggtaaaga tcggtgttat ggatggtatg ggtattttta 1322221 ctgaagccag ttatcgtatt ttcgattgca tatattttgt ttcggcttgc cggtaaaaaa 1322281 gctgtgtcac aaatgaacaa ttttgacctg cttttgacct tcgcaatcgg aaccattatc 1322341 agtgagccga tccttacatc caagctgccg atgtcaattt attatgcggg tgcttttttg 1322401 gtgctttatc ttatcatgag caagctctct ttatctaata aatggcgatg gctcctagtc 1322461 gtgagcccga ctgtcctaat ccgaaacggg gatattgatg aacgcggcct tcgtaaagaa 1322521 aggctgactg ttaatgagct gctcggaaag ctgagggaaa agggctatgc cgacccggct 1322581 gacattgatc ttgctatcat tgaagaaacg ggagaagtaa gcgtcatccc gaaagaggaa 1322641 gcgagagcgg tgcaggtgcg ggatttgaat atggaagctg aacggaattt tatcccgatt 1322701 ccgctcatac tggatggcga aatccttgat cataatttga aatatctcca aaaaaaccga 1322761 tcctggctgt ttgagaagct tgaggaaaaa gggtacagcc ccaaactgct gtcttcgatt 1322821 atccttggca cgatgaatgc acgcggtgat atatcccttg atttaaatac cgctaatgaa 1322881 ccgcagcatg atccttactt atataaaccg ggaaataaca attaagatgg ctctctcttg 1322941 taatgagagc ttttttcttt tttaaaggga atttttgttt ggtgtcaaat gtacctagtt 1323001 aggaggggaa ctgaacatga aggacttatc cataagaaac gacatggcgc caacggtcag 1323061 tttgctgtat tccgcagtgg aagaaaacag tctccgtctg gcttccatcg taagccatat 1323121 gacacacagt gaactttact ataaggggcg ctgccaaaca aaaaacagca cggctcagct 1323181 tttgcaccat atcacaaatg ttgatatcag atgggtctgg cgtatcaagg aaaatcggat 1323241 cccggaccat attgaacagg catacggccc gatgacagat gaaagcggac ggctgcctga 1323301 accggtgaat cagccagact tagatgaact cctgaaaaga catcagcatg tagtagagaa 1323361 gctgaaatcg gtatgcttca ctttaactga aaatgctttg aaccagccgc tttccttcga 1323421 aggtgacacc gcgacgatac gatggggaat ttggcatatg gcagatcata accgctatca 1323481 tcaggcacat attgaagctc tcaaaaaaga atggaagcag gatgtggcga agtatgaacg 1323541 ctaaaacgaa gcttgtgact gatcgaattc gtttgcgctg tatggaagat cgggatcaag 1323601 ccactttgtt tgggctgctt tttaatgatc ctgacgtcat gacatattat tccggtttaa 1323661 aagataagag gcaaacccgc gagtgggtca attggaacca acgaaatgaa aaagggtacg 1323721 gcgttagtct gtggatcgcc gaagataagc ggacagggga gtttttgggg caatgcggca 1323781 tcgttcccca gcagatcgaa aatcaaaccg taatggaaat tggctatatg tttgcccgcc 1323841 gccactgggg gaacggctat gcgcaagaag cggctcgggc ctgtctggac tatggcttta 1323901 acgagcggca gttcggcaaa atggcggctt tgattgatcc gggtaacaaa gcgtccatac 1323961 gggtagcgga gaaaatcggc atgcattaca gcaaaacgat cagaaaatgg aataaaccga 1324021 tcgcggtata tgaaagaaaa tcttacaatt gaaagataga gctgagttta gtatcatgat 1324081 atcatgtaaa gttttctagg gttccgcatg tcaattgaca tggactggtc cgagagaaaa 1324141 cacatacgcg taaatagaag cgcgtatgca cacggaggga aaaaagcccg ggagagtcaa 1324201 tctcatgtga gacgactgtc cggggttttt ttgttttcgg agaatcttaa tagatagaaa 1324261 ggaatgactc aaaatgaaat ggggattggt cgtgcttgcc gctgttttcg aggttgtttg 1324321 ggtgataggc ttaaagcacg ctgactcagc cttaacatgg agcggcactg ccatcggcat 1324381 catattcagc ttttaccttc taatgaaggc gactcacagt ctgcctgttg gtaccgtgta 1324441 tgccgtcttt accgggctcg gcacagcggg aacagtactt agtgaaatcg ttctttttca 1324501 tgaaccggtt ggatggccga agctattgtt aattggcgtg ctcttaatcg gtgtaatcgg 1324561 gttgaagctt gtgacacagg atgagacaga ggaaaaagga ggcgaggcat aatgctgcac 1324621 tggatcagtt tattgtgcgc gggctgttta gaaatggccg gcgtggccct tatgaatcaa 1324681 tatgcgaaag aaaaaagcgt gaaatgggtg ctgttgatca ttgttggttt tgccgcttca 1324741 ttttccttgc tgtcgtacgc aatggaaacc actccgatgg gaacggctta cgcggtctgg 1324801 acaggaattg gcaccgccgg cggggcgctt atcggcatcc tcttttacaa ggagcagaaa 1324861 gacgccaaac ggatcttctt tatcgcgttg attttatgct cagcagttgg tttaaaaatt 1324921 ctgtcataaa ttgattttta tcaaatcttc agtataatgg ataaatagtt tagacttaca 1324981 aagataagag ggattattca tgaaatcata tatgactcag cggttggacg aataccgtga 1325041 cggaaatgag gataaaggtc ggctcttggt cagctgcccc gatcagccgg gtatcgtctc 1325101 tgcagtttcc gcgtttttat ttgaacacgg tgccaatatt atagaatcaa atcaatatac 1325161 gacagaccct gaaggcggcc ggttcttcct gagaatcgaa ttcgactgcg caggcattcg 1325221 tgaaaaaaaa tcatcacttc aggcagcgtt tgcctctgtt gcggaaaaat tcgacatgac 1325281 atggagctta actttggcga gcgaactgaa gcgtgtcgcc attttcgttt caaaggagct 1325341 ccactgcctg catgagctga tttgggaatg gcaaaccggc aacctgatgg cggagatcgc 1325401 tgttgtcatc agtaaccatg aggaagcgag agagctggtt gagcgcctga acattccatt 1325461 ccactatatg aaagcgaaca aagacatcag agcggaagtc gaaaagaagc agcttgaact 1325521 gctggagcag tacgatgttg atgtgatcgt gctcgcacgc tatatgcaga ttctaactcc 1325581 tgattttgtt tcggctcatc cgaatcgcat catcaatatc caccattcat tcctgccagc 1325641 ttttatcggt gcgaatccgt acaaacgggc ctacgagcgc ggcgtgaaac tgatcggtgc 1325701 gacatctcat tatgtgacaa acgatcttga tgaagggccg atcattgaac aggatattga 1325761 gcgtgtggac caccgcgata atgcggaagc gctgaaaaac atcggaagaa caattgagcg 1325821 cagcgtgctt gcccgtgctg tgaaatggca tttggaagac cgtgtcatcg ttcatgaaaa 1325881 taaaacaatc gtctttaact agactgcaag aggcccgcgc aatgcgggct atttttgatg 1325941 acaaaaaacc ttgacaagtg tcttttttct ttgcataata taaaaaaatc attgagcgtt 1326001 gaagaggatt agtaagcaga cctttctgtg acagagagca aaatgaatcg ctgaaacatt 1326061 ttgccgcatg aaacctgccg aacctgcctt ggagtcctag ggggaaaacc taggcgcata 1326121 acctggcgtt acaggagagc ggagcgtgca caagcgcgtt caatcaaggt ggtaccacgg 1326181 aaacccattt cgtccttatg aatcaggatg aaatgggttt ttttattgta gaagagccgc 1326241 ggaggagaat aaatgaaaaa acaaagaata gtagtgaaaa taggaagcag ttcgctcacg 1326301 aatagcaaag gaagcattga tgaggcaaaa atcagagagc atgttcaggc gatttccgtg 1326361 ttaaaaaaag cggggcatga aatgattctg attacctcgg gtgccgtagc ggcggggttt 1326421 tccagcctcg gttatccatc ccgtcccgtt accatcaaag gaaaacaggc ggcggccgcg 1326481 gtcggacaaa cactgttaat gcagcaatat atgaatcaat ttaaacaata ctcactgact 1326541 ccgggacaaa tccttttaac gagaaatgat ttttcgaaaa gagaacggta tcgaaacgcg 1326601 tatgctacga taatggaatt attagagcgg ggcgtcattc cgattatcaa cgagaacgat 1326661 tctacatctg ttgaagaatt gacattcgga gataatgata tgctttctgc gttagtcagc 1326721 ggattgattc acgcggacca gctcatgatt ctcactgaca ttaacggact gtatgatgcc 1326781 aatccaaatg aaaatcctga ggcgaaacga tttgattatt tgccagagat cacgcctgaa 1326841 ttgcttggat atgcaggttc agctggatca aaggtcggca ccggcggaat gaaatcaaag 1326901 ctgttagcca cacaaaccgc gctgtctctg ggagtgaaag tattcattgg aactggcagc 1326961 ggagagcaaa aacttgcgga cattttggac ggcaggggag acggcactta tatcggagac 1327021 aaagaactat cttcggttaa caacacaagg cagtggattc agttccactc gccgatatcg 1327081 ggagaaatta tcattgatgc gggtgccgaa gaggcgatga tccataatgg aagcagcctt 1327141 ttgcccgctg gagttgtggg cgtgaacgga agctttccga aaggggcggt tgtggaagtc 1327201 aggggaccgg gcggcgtgat cggcaaaggc caaactcatt actcctccga ggagattatg 1327261 gaggctaaag gcaaacgcag tgacgaactt gattttgaga aaacgtttga ggttattcat 1327321 aggaatgact gggtcaatgt aaaagactag gaggcggaaa aatgagtgaa gtttctgtaa 1327381 aagcgaagct ggcgaaagaa gcagcagccg aaatgatcat gaaaacaaca gccgagaagg 1327441 atgaggcgct cagcctcatt gcaaacggac tccgcaaaga actggatttt ctcttggcgg 1327501 agaatgcaaa agacattgtg aacggaaaag agaatggttt aacaccggac atcattgacc 1327561 gtctctcatt ggatgagaaa cggatacgcg atatcgcgga cgcggtggag ctcttaatcg 1327621 acttagcgga cccaatcggc gactctcttg aaacgattga aaaagaaaac ggcctgttta 1327681 ttgaaaaaat ccgtgtgccg ctcggtgtcg taggaatgat ttatgaggcg aggccaaacg 1327741 tcacagttga tgcggctacc ctttgcctga agacagggaa cgcggttgtg ctgcggggaa 1327801 gctcctcagc catccacagc aacaaagcgc tcgtcagtgt catttacaga gcacttgagc 1327861 aatcagcgct tccgattcac gctgtgcagc tgattgagga tacgagcaga gagacagcaa 1327921 aagagctctt tacgttaaat gatggcttag acgtattgat tccgcgcgga ggcaagaaac 1327981 tgattgatct cgttgtgaga gaatcaacag ttcctgtatt agaaacggga gcaggaaact 1328041 gccacatatt cattgacgaa acagccaaac cgcaaatggc agaaaaggtt gttgtaaatg 1328101 ccaaaacgca gcgcccttct gtatgcaacg cgattgaatc attgctgatt cacaaggctt 1328161 gggcaagaca gcacggaaaa gaattgctgg accagctgga aaacgcggga gttgaaattc 1328221 gcggtgatga attggtatgt gaacttcatc cttcaagcaa acaagcatca aaagaagatt 1328281 gggaaaccga atttttagcg cctgtcctca gcgtaaagac ggttgaaaac gtccaagaag 1328341 ctgtaaagca tatccaacaa tacggcacca atcattctga agcgatttta actgaaaatg 1328401 acaaaaatgc ggtatatttt caaacggctg tcgatgctgc cgctgtctat cataacgcgt 1328461 caacccgctt taccgacggc tttgaattcg gctacggagc cgaaatcggc atcagcacgc 1328521 aaaagcttca tgcaagagga ccgatggggc ttcctgcact gacttctaca aaatacatca 1328581 ttaaaggaac tgggcaaatc cgtgaatagc ggggtaatgt tcaatgaaaa agcttatctc 1328641 attacgagat aagctttttt atacgcgaaa aattgacatt tcaaatttaa ttgtgtacaa 1328701 tttaattgta taaaatatat tgggggaatg aaaaatgagt cagccattat ttaccgcaac 1328761 tgtttcagcg gtaggaggaa gagaaggaaa ggtcatttca tcagaccgcg ttcttgagct 1328821 tgatgtcgca atgccgggga caccgagagc caagaaatta gaaaaagcga caaatccaga 1328881 gcagctgttt gcagcaggtt atgcagcttg ctttgacagc gccctgcagc ttgtcgcaag 1328941 aacagaacgg gtaaaagtag agacagaggt tacagcaaat gttagcctgt taaaggatga 1329001 agcggaccag ggctataagc tgggtgtgac gctgcaagta aaaggagaag gagtcagtgc 1329061 atcagaattg gaggcgcttg tgaaaaaagc gcacggcgtc tgcccgtact caaaagcaac 1329121 ctccggaaat attgatgtga cacttgaagt tgctgaataa ataaaaagag gatgcctgta 1329181 caaggcatcc tcaatttttt tgatgaagtg tttccagtaa tgtatataga gcggacttta 1329241 actgtttgag atcctcccca gactgctttg agagccccag aattgtccct ggaatgtcaa 1329301 ccgctttttc ttttaataac gctccgtcct ctgtcaggct gatcaacacg gaccgctcat 1329361 cctcttcaga tctttttctc gtaatcaaac cctgttgttc cattcgttta agcatcggag 1329421 tgagcgttcc tgaatctaaa tacagctgtt cgcccatttt tttgacagta agcgtttcat 1329481 gttcccataa caaaagcaaa gccaaatatt gagggtatgt tatattcagc ttatcaagca 1329541 gcggcttgta ttgctttgtc atctcccgcg aactcgcata tagcaaaaaa caaagctgat 1329601 tctccaattt catatgatca aatttatttt ccattttgtt caccaactct tttttgtcat 1329661 tcgattctat tgtatctgaa aaacctcact tttcctattc tcggcaaaca tagcatgttt 1329721 aaaaagatca gaaagggaaa tataacaact agatacaaat aaggaggttg ggaaatatgg 1329781 cactatttac agcaaaagta accgcgcgag gcggacgagc aggacatatt acatcagatg 1329841 acggtgttct tgattttgat attgtcatgc caaatgccaa aaaagaagga caaaccggca 1329901 caaatccgga acagctcttt gcggcagggt atgctgcatg cttcggcggc gcgctcgaac 1329961 acgtagccaa agagcagaat atcgaaattg attcggagat tgaagggcag gtcagcctca 1330021 tgaaggatga gagcgacggc gggtttaaaa tcggtgtcac acttgttgtg aacacgaaag 1330081 atttagatcg ggaaaaggca caagagcttg tcaacgccgc tcatgaattc tgtccttact 1330141 caaaggcaac cagaggaaat gttgatgtaa aactagaatt aaaataatga ccggcatcct 1330201 gaggattctc aggatgtttt ttggtgtcgg acatgcgggg cgggcacaga tttatgataa 1330261 aacttcagag aagcgtttga agcatgcctt taaaccaaaa gttacagatg aagcgggtgg 1330321 ctggcacggt gtctgccgtg ctgaattgcg cgtatatgct gttttgtatt tgcacagggc 1330381 atagcggcta cttggagaaa taacaaggac caggccgcgc atgcctgatc cttttaatat 1330441 tctttcttat tggcgaagtt ccgccatgct tgaaacgggg ataaatgctc tgttagtgtc 1330501 acttgataaa aggggatcgt tctttcttca gcaggtttat caatttcttt ataaatgaat 1330561 gaatcatcaa acccggcttc ggcagcgtct gtgtgctcag ctgcatagaa aacggcttta 1330621 ggccgggccc agtagatggc gcccaagcac attgggcatg gttcacagct cgtatacaaa 1330681 atgcagtcat caagctggta ggctcctagc accttacagg ctttccgaat agctgtgact 1330741 tccgcgtggg cagtcggatc attgcttgtt gtgacgttgt tctgtccctc tgcaataatg 1330801 gctccgtctt tcacgataac ggctccaaaa ggcccgccga ttcctgcatt cactccttca 1330861 catgcgagag tgacagcccg ttttaagaac gtttcatgat tcatcccaat ccctcctgtc 1330921 aatagagtgt tattagtata gccgaaaaga atgcaaagaa cattcttaaa aaagtgcaaa 1330981 ataaacaaag tatttggggg atttgctaaa taagaaaccg attgtggctg tattatagaa 1331041 aaaaaccatc tgccaaatgc agatggtttt ttcaaattat actagctgtg tctgctgtgc 1331101 tcttgcctgt tttgcggctt caaccatatt tttcaatgct gcaaccgttt cttcctgctg 1331161 tcttgttttc aatccgcagt ctggatttac ccagaagcgg tcagtcggac agacggcaag 1331221 cgcatcaacg ataatattgt acatttcttc agttgacggc acacgagggc tgtgaatgtc 1331281 atatacacca aggccaagcc ctttcaaata cgggtggttt tttaagtaat ctaaaaatcc 1331341 tccgtggctt ctgctatgtt cgattgtaat cacatcggca tcaagatcat tgattgtatc 1331401 aacgatatct tcgaagttgc tgtagcacat atgtgtatga atttgtgtct cgtttttcac 1331461 ggaagaagtg gttaatctga aagcttctgc cgcccaagtc aaatactcat cccaatcgcg 1331521 ggttttcaat ggaaggcctt cacgcagcgc tggttcatcg acttgaatga tttgaatgcc 1331581 tgcgtcttca agcgctttaa cttctttgcg aagggcaagc ccgatttgga aggcgatttc 1331641 tttcctcgag atgtcgtttc gagggaaaga ccagtttaag attgtaaccg ggcccgtcag 1331701 cattcctttc acatgcttgg aagtcaatga ctgtgcgtag actgtgtctt tcactgtcat 1331761 cggttcaata aattcaacat ctccgtaaat gactggcggg cggacacagc gtgagccgta 1331821 tgattgaacc caggcatatt tagtgaaggc gaaaccggcc agcttttcac cgaagtattc 1331881 gaccatgtct gtccgttcaa attcgccgtg aacaaggaca tcaagctcca attcttcctg 1331941 aatatcaatc catctttttg tttccgcatt gataaagttt tgatactgtt catcggacca 1332001 ctcagctttc cgccattttt ggcgtgcgct ccgcacttca gcagactgcg ggaagctgcc 1332061 gatcgttgtc gtcggcaaaa gcggaaggcc gagagattca ttttgtaggg ctaaacgttc 1332121 ttcaaacgga atcgggcgct tgaagtcttt atcagttaat tgctcaagct ctttcttttg 1332181 ttcagaattg gcgcctgttg caaactgttt aagcgcctgg atatcagcct tagcctgctg 1332241 aatctcttcg ctgatcgccg cttttcctga tactaagcct tctttcaaag ctgtcagctc 1332301 ggccagcttt tcttttgcgt aggataatcc gttcaatagg tctttttcca aatgctcatc 1332361 agggtgtttc gctactggaa catgcagcag gctgctggaa ggctgaatcc acagttcatc 1332421 aacttttgca atgctgagaa tatcaagaac ggcatcgaga cgctcttcaa ggtccgcttt 1332481 ccaaatgttg cgtccgtcga taacgccggc tgccagcact ttatctgtcg ggaagccatg 1332541 tgttttaagc tgttccaggt ttctgccttt gtcgtgaacg aaatcaaggc caattccctg 1332601 aaccgggtaa gagatcagct cttcataagc atcaacagaa tcaaaatacg tctgcaaaag 1332661 cacattcaag gatgaaagct cacttgtaat gctttcaaat aattcttttg cgccgcgtac 1332721 atcttcacta gaggcggtaa cgagcgccgg ctcatcgatt tgaacccatt ttacgccttc 1332781 ttcttcaagc tctttcaaaa gctgtacata taatggcaca aggcgttttt ggatcgcttt 1332841 tgcttcagac ggttcatagc ctttagcaag cgtaacgaac gtataagggc cgacaatcac 1332901 aggctttgtt tccacaccgt attcctgttt gatccggcga taatcttcga gttgtttgtt 1332961 tcttgtcaga cggaactcaa tgctctcgtc atattccgga acgatgtaat ggtaatttgt 1333021 attaaaccat tttgtcattt cactagatac agcgtctttg attccgcggg cgatagcgaa 1333081 gtatgtatcg gtagcgtcag tcaaatgtct gaaccgtttc gggatccagt tgaagctgac 1333141 tgctgtgtcg agtacatggt catactgtgt gaaatcagaa acaggcacaa catcaatctg 1333201 ctggtcaatt tgtgttttta ctgcggataa aaatagttcg tcgatttgct tcaaaaacgt 1333261 atctttatca gtactgcctt tccaatacgc ttcaagtgct tttttccatt cccggttcag 1333321 tccgattctc ggaaatccta aattcgatgt tttgatggtt gtcattgttt ctcctccttt 1333381 atatgtaaaa cactctcttt cacccgcgga tacaggctgc taagaggttt tctcacaaca 1333441 aaaagcctct ttcccatgag agaaagaggc ttttctacgt aaaacactgc ctctctcatc 1333501 tctcagacac aatctgatgg aattagcacc gtgccttatg agacatcagt ctcggcgcga 1333561 aaagcagtgc gccccatttc acaatggtat tacggtcggt tgctgttggg gtcaaaaggc 1333621 caatccctcg cccaactctc gataagagaa aatgttatta attttttgaa aagttgaatc 1333681 atttgttggt aatcttaaca gtaattcaaa ttcattgtca acatagaatt tgaaattttt 1333741 atttacatga tgtggtgtat attatataag aaaaataatc ttatagggtc aacaaatgtg 1333801 attgctctgc tttttctgcg agctcatcag gagctgttaa atacaggaat ccattgcctg 1333861 ccagcgtttt tgcaatatca agaggaagtg tcctgcggat tagctgtgcg aaaacctcag 1333921 attcagaaag ctttctttga aatgattctt cttcatagct tttgattaaa gcaagcgcac 1333981 cgctgacatg aggggcagcc attgaagtgc cggtcagctt accgtacttc ttgttgggaa 1334041 gggtggataa gatgttttct cctggtgcca caaggtcaat ctctttattc gcgttagaaa 1334101 attctgataa ttctcgcgct acagaaacag atccaactgc aatcacttca ttataagctg 1334161 cggggtagga aagctcttct gtgcgttcgt cgccgtcacc ttcatttccc gctgcacaaa 1334221 cgacaagcac tccgtttttc actgcgtttt tcactgcttc ttttagctct ggcacatcgc 1334281 ttggccctcc aagggacatt gagatgatgt cgactttctg ttccaccgcg tagttgatgc 1334341 cgttaattat ccattcgtat tgtccgctgc cgttctcgcc gccaagaacc ttcacaatca 1334401 ataggcttgc ctcaggcgcg actccggcaa tgcctccgtt tgaatcatta gctgcaattg 1334461 ttccggcgac gtgtgtgccg tgtccgttgt agtcggaaat cgcatcttcc ttgccgccgt 1334521 cgtcatccgt gaagttcttt ccgccgatga tttgattttt taaatcaggg tggcttgtgt 1334581 cgcagcctgt gtctaataca gcaactttaa tatttttgcc ttttacccct tttgcccaca 1334641 tttctggcgc cttaatcact ttaatgccct caggaagctc gtttacatcc atgatctgct 1334701 cattcgtcac atacgggatc aagcggattt caccattcat aaaaaagccc tcctttttta 1334761 tgcttgcaag tggattcaag ggtgttgcct catattatat gaaaaaagca agcgctcgga 1334821 cagagccatt tgaagcattt tgaaaaaata ggatacacac caaagaatta gtaatcttca 1334881 aaatattgga tggcttcaac atgtatgact gggattcaac tgtaagtcaa gttataatag 1334941 tgttggggaa aggagcagtg tcatgaaact gaatgaaaaa ttatatgcat ttttttcaga 1335001 gcatgtggaa caaatggccg aggaatggat tgaaacgatg gaggaaagtg atccgaattc 1335061 gctttacgcc ctacataatg caacagtaac ggaagaattg aaagagcagg acagagaatt 1335121 ttaccggcat ctgaattaca tgtatgtttt accggaaaaa caatttctcg aagagtttca 1335181 agagtgggtc attgagctga ccaacgatca aaaacatctc gacacaccgg ttcagtatgt 1335241 cattcgggag tttatgagaa acaggagatt atatacgaag tattttgaga agttcgcaga 1335301 agaaaatgaa tcagcgtttg aaccgggaga gaagcaaaaa tgggcagatt tgattgtaaa 1335361 agtatttgat ttcaccattt atacattcgt tgatcacgct gaaatgaatg ccaagcagca 1335421 attaaacgcc caaagagaaa tgatattgga attaagctca cctgtcatta ccctgagcaa 1335481 atcaacagct ctgctgccgc ttgtcggtga cattgatacc gaacgggcga agtttattct 1335541 ggaaaacacg cttcaagctt gtgcgaaaag acgtgtggag catctgttaa tcgatctgtc 1335601 aggtgttgtt gtggtggata cgatggtggc gcaccagatc tttaaattga ttgaggcgct 1335661 taatctgatc ggtgtccggt caaccctgtc aggaatcagg cctgaaattg cgcaaactgc 1335721 tgtacagctg gggattgact tttcgaatat tactattaaa accaaccttg cccaagcatt 1335781 aaactatcat caataaaaaa atccgctatc tgtgatagcg gattttttat gatgcgaaac 1335841 ataaagatac gagaaaggat cccgcgaata ataagaggac gaggcaaaag aacacccagt 1335901 cgcgccggtt cacgctcaat gtcctgtagt atgtccggtt tctgcttcct gtaaatcctt 1335961 tcgattccat cgcaagcgct gtccgttccg cttttctgat ggcgcttgcc aatagcggta 1336021 tggtatatcg ttttaacgca ctgattttat taatgatgcc gctctccgcc gctcctcctc 1336081 tgattttatg agcctgctga atcagctgga cctcatcctt taacagcgga agaaagcgaa 1336141 agcctgcaat gacaccgtac gcgagctttg gtgagagcct gcactgctgg acaaggctca 1336201 gcataaatag aatcggatcg gttgtaaaaa caaacatcat cgataaggcg gaaaagcata 1336261 aaatacgaaa cccgagagag atgccgacag acacattatc gctgttaatg gagatagggc 1336321 ctgcttgaaa caaaaaatta tccggtgttg tcggcacttt tccaaaaact gcggctgtcc 1336381 acacgcatcc gaatgctaaa atcaaaaacg gaatcgtaaa caacaaccat tttttcaatg 1336441 ggattccggc cgccagtaaa acgcccgcaa cgatgatgat ataaaaacat gccggagtgt 1336501 aagggttgta aataaacgac agcatgacga cacaacaaaa aaccgccgcc gctttcacag 1336561 tcggattaat gagatgtaac ggttgcttca tcacgcacct cctcttgaaa tgccatccat 1336621 tcatatagaa ggggaagggt gagctttgct ttttgaacaa gccctgtttc ttgagaaaac 1336681 aactgcgctg gagatccgtc aaaggccagg cctgtatcgt gaagcacaag cacgctgtca 1336741 gcatacgaag agactagctc catatcgtgt gtaatcataa ggacagcagt tccctctgcc 1336801 ttgatacgtt gaatcatttc catgcattca gccgccgtgc gggcatcctg gccaaaggtt 1336861 ggttcgtcta ataataaaac ctttacgtca tgcatgagca tagtagctac gctcagtcgc 1336921 cgtttttgcc cttggctgat cgcaaacgga tgatgatcag ccaaatgcgc aagaccaaaa 1336981 cgctgcagca ggtgttgcgc ttttttctca gtttcagcat ttgctttctg gccgaacaga 1337041 agctcgtcat acaccgtatc ggtgacgaat tgatgctcag ggttttgaaa aacaaatccc 1337101 atccgtttac gcaattcttt ttctttatat ttctgcagcg gctgatcata gagaaggatt 1337161 ttgccgcttt gcggtttcat gagactggcc agaactgata ggagcgtcga ttttccagtt 1337221 ccgttcggac cgacaagcgc cgttaaagag ccttcgcgca acgaaaagct gatgtctttg 1337281 aaaatcgcct gctgtcctct cgcgaacgaa aggctgctga cttcaagcac actctcccca 1337341 gaaggggctt tcttcttttt gacatgcccg gcaggaatag gctctttgaa cagcatctct 1337401 tttgataaag taaacggcat actcagcttt tcctgcagat gacagacctt tggaatggcg 1337461 atgcccaatt tctttagtgt ctccgcttca tgctgaaata gatttttcgt caggccatcc 1337521 agtgcctttt tgcctgattt gtcgagtacg atcgttctct caatccaagg cgcccattca 1337581 tcaagctggt gctcaatgac gaggaggctg aaaccttttt cccgctgaag atccttcatc 1337641 agatgaacga actcccgagc tgagaaaggg tctaaaagag aggtcggctc atctaaaata 1337701 ataagctcag gctccatcgc caaaatacag gcgagagcca ctttctgctt ttgtcctcct 1337761 gaaagggttg agatcatttt ttcttttaaa tgggtaatgc gtaatttttc taatacggcg 1337821 ttgattttct ctgtcatttc ttcttttgga atttgcagat tttccagccc gaacgctatt 1337881 tcgtcctcca ccgtcagcat gcagaactgc tgatcaggat cctgaaaaac gaccccggca 1337941 tgctgagtaa tcgtttcgga ggtttcagca tctgtgaccg gcttttgaaa tagaaataca 1338001 tgtccggact gaatgccgtc gcaagcctcc ggatatagac cgtttaaaca aagggcgagc 1338061 gagcttttac cgcatccgct cggtcctaat aataaaacac attctccttt ttgaagctca 1338121 aacgaaatgt cttgaaaaac cggtttctcg tcttcttcat aagagaagct gagctgctca 1338181 accgtcagaa gctcatcaaa ggcttgcatg ttctgacgcc cgcttccgtt tctttttcag 1338241 ttcctttccg agtgccattc cgtttaacac acctgtataa gcgagagagt cgctgacagc 1338301 ttttccgaga agccccgcca aaagcgcgcc ggaaatgagg cggatcacaa gcataatgag 1338361 cagataacct ggtgaatagg ctgcatagcc agaaacaaag agatcataga taaagctggc 1338421 tactgaagac cccataccgg ccagcataag gacagggaga gagtatgctt tccagcgtgt 1338481 tgcaagaaat acagcctcag ccccgagccc ttgaacaatg ccaatgacga tgaccatcgg 1338541 gccagacgga tttcccagca ggcactcaac gagagcggca atgatttcag aaacgagcgc 1338601 cgcacccggt tttcgaatca tgtacgcggc gatcacagaa acgataaacc aaatgccgta 1338661 aattggttca taggcgattg gcccaaacat acctgcaagt acgtttccga aatgtgtaaa 1338721 taataaataa acaacggcaa atacgatact gataacggac atgatgacaa tttcttttac 1338781 tttccagctt ttcatgttat ccctgctttc tgttttttct tgatggactg ttagccgaaa 1338841 gattcacagt catggtgatg tggtttgttt gctgctcagc catgcggaaa acggcctcca 1338901 atgtgctgaa tacgtcatgc gcatccccgt caagctcgct cgcgtaatgg acaccctgta 1338961 cgaaagtgcc ttgggctttt gcaatgtcga cagcctccat aatcaatccc atataatccg 1339021 gctcattcat tggataaagg gcaaattggc acggcgcttc cgccttcaag cctcggacag 1339081 catcttcatt gacacgctta tcacctttgg aaagatatgt atccccctgt gtgtcacccg 1339141 ggcatccaat ggaaaacgtg ccgttcatga cgatgtgttg ttcgctgttt gctgcatgaa 1339201 ggtaaatggc ttttgcagca tcgaatacat gatcaatcga tccgcgtaac accgtgctga 1339261 tatggtcggt tttcgtccaa accttggatg tatctgtttt tttcagcgca gacttgatca 1339321 cactgataaa atcatccgtc atcggatata aagagaagcg aaaaccggcg attctgcttg 1339381 taccgcaaat atgctccatt tctccgacct cctgtttttt tggtaaaata aaaaactgca 1339441 tatcctaagg gaatatgcag tcatagatcg attaagcgca caaaaaaata caccattcgg 1339501 tcaacctgca cttccccacg ctggtattat ccagatcggg tcataaggga tcaaagcgcg 1339561 tttcttccgc gctttatctc agccaaaaca gcacccctag tgctttccgt atacaatttt 1339621 ttattttgac atcataatag atgataagaa tcattttgta aacaacgaaa tcattttttt 1339681 catataggga cgggagagga tggtcaaatt tggaaaaagg acacatatta attgtggaag 1339741 atgaagaaaa aatcgccagg gttcttcagc ttgaattgga atatgaagga tacagcgtca 1339801 cgatcaaaca caatggcaca gaaggtcttg atgcggcagc ggaaggcggg tattccttgg 1339861 tgcttcttga tgtcatgctt ccggggctta gcggactgga agtgctgcgc cgcttgagaa 1339921 aaacggattc gcagacaccg gtcatattat taacggcgcg agacagtatt cctgataagg 1339981 taacaggtct ggacatcggt gcaaatgact atgtcaccaa gccgtttgaa atcgaggaat 1340041 tgcttgcgag aatcagggcg gcgctgcggc aaaatggaac aaaaactgaa gatatcggca 1340101 cctttcttac atatgacgat ttgcgggtga acgaaaaaac ccgtgaagtg agacgcggag 1340161 acaaagaggt ggaattaacg ccgcgggaat ttgatctgct cgtctatatg ctaaagcatc 1340221 cgcagcaagt gctgacacgg gagcaaattc taagctcagt atggggattt gattatatcg 1340281 gtgatacaaa tgtcgtggac gtctacataa gatacatcag aaaaaaactg gactatcctt 1340341 acgaaaaaca gctgatccat acgattcgcg gggtcggcta tgccattaag gggtaaacga 1340401 tgaagctgaa gaccaagatt catctataca cttcgatatc actgttgatt ttattaattt 1340461 tggttcatac cgcagtatat ctcatttttt cgtctgcgct gacatcaaag gatgcggccc 1340521 ggcttgctga tgagacggat aacattgccg aagcgctgcg tgccgctgaa acagaaggag 1340581 tggctttgca ggatatgctg caggcctatc ttccggcaaa tggcatggtg cgtgtagtga 1340641 atggtgatca aaaagccgtt atgacgatca caaaagaaaa agcctataaa gattttcctc 1340701 tctcttttca tagcggcgaa acggcagatg tgaggaaacc tgacggcaag ctgtttgccg 1340761 aggctgctgt tccggtgatt tggaccgatg gacaagtcgt gtctcttcag ctggttgaaa 1340821 gactggagaa cacagaagag agtctgtttc tgctgaaaat catcttaatc gctgcaagtg 1340881 ctgctgtctg cattgcttct ttttttgcag gcagcttgct agcccgccga atcatcaatc 1340941 cgatcagacg attaatgatc acaatgaaag acatacagcg agacaaagaa tttaaaacga 1341001 tttctttaga aggacagtcc aacgatgaat tgtatcaaat ggggctgaca tttaatgaaa 1341061 tggcaatgat gctgaaggag cactatgata aacagcagca atttgttcaa gatgcttcac 1341121 acgaattgaa aaccccgctc actattatag aaagctacag cagcctgatg aagcggtggg 1341181 gtgcaaaaaa gccggaggtg cttgaggagt cgatagaagc cattcactca gaagcggtgc 1341241 atatgaaaaa actgaccaat cagcttttgg cgctggccaa aagccatcaa ggactcgagg 1341301 ttgatctgaa aacaatcgat ctgattaaag cggcgcgcgc ggttatgcaa acgctccagt 1341361 ccgtttatca gcgtgacata ttgcttgaaa cagataaaga gagcctgctt gtaaaggcag 1341421 atgaagaacg catcaagcag ctgttgacca ttttgcttga taatgcaata aagtatagtg 1341481 aaaagcctat tgagatgtca gccggaacga ggaatggacg gccatttcta tcagtgaggg 1341541 atgaaggcat cggaatacct gaggagcata tcccgcattt gttcgaacgg ttctaccggg 1341601 cagatgaggc acgaaacaga aaaacaggcg gaacaggttt aggcctttcc attgccaagc 1341661 aaatcgctga tgagcatggc attgagctgt ctgtcaaaag caagccggga caaggaacag 1341721 ctgtcaccat gcaattcagc gaacagaatg ggggaggccg atgactaaaa caataaaaac 1341781 agtatctttt gctgcagcag ccattttagt tgtcatcatc tgtacgtttc tcatcattcg 1341841 gcaaacccat gagaacgtat tgtcaaagga gactgtcgta aaaaaagtcg aagcctctta 1341901 tgaaggcaag gtcacgaaag caacacaatc aaaggataaa aaaacatatg atataaccct 1341961 tgaaaatcca aagggaactt actttgtaaa agcagacgca atatcggctg acattctttc 1342021 aatgaataga gtaaaagcag tgaatccatc tgccatgaca gaaaaagaag ccgagcatct 1342081 cgcgcttgag cgggtgccgg gaacggtcaa aaaacaaaca cggcaaagtc aagttgccac 1342141 ttataccata caaaaagaag acgggaaaac atacgaagtg aaggtagaca tgcaggcaaa 1342201 aacagtcttg tctgccgatc aaatcagcag caaagatcaa caaaaaacgc cgattacgaa 1342261 aaaagaagcc aaaacaattg cagagcgaaa aacgggcgga acagcggatg acgcagatct 1342321 cgaagaaagt gagggcactc tcatctttga agtagacgtt gatcttcctg ataataagga 1342381 agcgacagtg aaaatcaatg cctacacagg aaaggtagct aacattgtgt atgaagactg 1342441 acggtttctc atcaaattct catcttgctc tcgttttcct ttcatgttga gtatgtaaac 1342501 tgtactcata caaaacaaag gagggctcac aaatgctcaa gaaaaaatgg atggtcggtc 1342561 ttttagcagg gtgcctagcg gccggaggat tcagctacaa cgcgtttgcc acagaaaaca 1342621 atgaaaacag acaggcttct tctaagacgg atgcactcac tgaacaagaa gcagaagcaa 1342681 ttgctaaaac agttgttgac ggcacagtag aagacattga cagagacctt tacaacggca 1342741 aagaagtcta tgaagtggag attgaaaaag aaggtgaaga ctacgacgtt tatgtagata 1342801 ttcatacaaa acaagcgctt aatgacccgt taaaggagaa agcagaacaa gtcgccataa 1342861 ccaaagaaga agctgaagaa attgctttaa agcaaacagg tggaaccgta acagaaagta 1342921 agcttgacga agatgacggt gcttacatct atgaaatgga aatccaaacg aagcaaggaa 1342981 ctgagacaga atttgaaatt tccgcaaaag atggacgcat tatcaaacag gagatagatg 1343041 actaatcaaa acccccgctg cagcgggggt ttttcatgat aagaaacctt cttttggaca 1343101 atctaagtag aaaaggaggc gaaacgcatg gaaaagaaag aggagcaata catcaatcag 1343161 gctgaatatg tccctcatcc gacgaaggaa ggagagtatg ccttatttct tcatgaaacg 1343221 tatcatttgc tttctgaaga tgacgagaca caaacaacag aataagggct taggcccttg 1343281 ttttgttccg taattgtgat gtaagcgcat ttattacttt tttgagttga catagcttgt 1343341 ttttttctgt aatctcagtg tgtcaattca attaggaact tcgttaggtg aggctcctgt 1343401 atggagatac gctgctgccc aaaaatgtcc aaagacgcca atgggtcaac agaaatcatc 1343461 gacataaggt gatttttaat gcagctggat gcttgtccta tgccatacag tgctaaagct 1343521 ctacgattga aggcgcccgc acgctttttt tgccgtgctt ctttcacctt caatcccgaa 1343581 ggcttttttt atgcctttaa aacgaaacca atcaaaggag gtgcggagta tggattctcc 1343641 ccattcgagt caatctgaag aagtacccat atactatgac agcaagacaa ttgattacac 1343701 gatgaggaga cgaactgccg caccttctgg cgaggccggc acgtctccgt agaggaggta 1343761 cgagtcccga tggttcaaaa catgacctat gacgaactca ttttacgcat cattatttta 1343821 ctgcgagacg ggaaaatcag ggattttaga agtgttattg atgagcttca gccctatgac 1343881 atggcattta tttttaaaga aatgccggaa aaacatcgcg cccgctattt atcttattta 1343941 actgtagacg atatcactga tatgatcggg gagctggaac gcgaatttca gcttgtcgtc 1344001 ttaaataaag tcggaaaaac aaaagcaaca ctggcgatga acaaaatgga caacgatgac 1344061 ctcgctcaat tgcttgaaga aatggacgaa gaactgaagg aacagctttt atccagcatg 1344121 gaagcgtcag aatcaaaagc tgtacagctc ttgatgaatt acccggctga ttcagcggga 1344181 cgcatgatga caaaccggta tgtgtggatc cctcagcatt acacggtaaa agacgcggtc 1344241 gtcaaactga aaagcttcgc tgaaatagct gaatcgatca actacttata tgttattaat 1344301 gaaagcaaac agctggttgg ggttctttcc taccgcgatt tgattctggg tgaacctgaa 1344361 gaaaaggtgc aggatttaat gtttacccgc gtcatatcag cagatgctct tcaggaccag 1344421 gaagaagttg cccgcctgat agaacgttac gattttttgg caataccggt tgtagaagaa 1344481 aacaacgtgc ttgtcggcat tgtgacggtt gatgatatta tcgacgttgt tattcgggaa 1344541 gctgatgagg attacgaaaa atttgccgct tccggtaaag acatcacctt tgacacaaaa 1344601 gcttacgtgg cggcataccg gcgtctgcca tggctgattt tactcttatt tatcggactg 1344661 atttcaggaa gcattatcag ctattttgaa gacgcgctga agcaggttgt cgcgcttgcg 1344721 tttttcatgc cgatggtgtc agggatgaca ggaaatacgg gaacacaatc tcttgcggtt 1344781 gtcatcagag gtttgtctaa agaagaaatg aacaaaaaaa cgattgtgcg cctgatcttc 1344841 cgggagttca gaacaagcat ttttatcgga gcggtttgtt ctgtgctgat tgcgattgtt 1344901 tctatcatat ggcaggggaa tgcgcttttg ggatttgttg tcgcctcttc actgttctta 1344961 accttaatca tcggcacgat gtcaggaacg attatcccta ttattttgca caaactgaaa 1345021 gtagacccgg cgattgcttc tggaccgctg attacaacgt taaacgatat tttatcttta 1345081 ttaatctact ttggcattgc cactgcattc attcactcat tataaacgta aaaagtccgt 1345141 ctcaactgcg agccggactt ttattattta acggtttttg taccgaaagt gagcattaag 1345201 ctgcccctcc agcatttttt tccgcacttg cggatcgttt tttaacatct gttctttttt 1345261 gcgcatatcc tttaaaatct ctgccgtctg tacgccgtct tcacgcttat tggcgatatc 1345321 catcagccgc tccacatcgg caaaggagta ttttcttgtc ccccttgaag aacgctgcgg 1345381 gtaaatgagc tttcgttcct cataatacct gatctgtctt acggacaatc ctgtcaattc 1345441 actcacaatt ccgattgaaa tcactttttt gtctttataa gaatgatctt ctgtggtcat 1345501 ttttccaccc ctggatgtct tttgataata gtatataaaa aacaaagaga aaaaacctga 1345561 cgcttgtcat attttctaac atcaaataga agatttttga aaaaatacgg aagaaaaatt 1345621 aacaagaata atgcgtaaca cccaagcgcg ttttatcctt tatgtaacga atcaaacgag 1345681 gaggaaggat aatcatggag gaagaaaaag cagtctcact ggcaaaagaa attatagagt 1345741 tggatatcaa gcgtgatgaa atgctggaga cgtttatgca gcttgccgga gaacaggctt 1345801 ttcaattatt aagatcggtt caaaacggac aataccgaaa atcttcgtaa acataaattc 1345861 tttacattag attcatacca cgttcattta aaaagagtat cttttgtata ggatacctca 1345921 aaatgaagga ggacgctatg agtaatttat tgaaatccgc tttagaaaaa gaacgacgcc 1345981 attattctga aaaactctat cagatagggg tttataataa agaggtcatg aacaaaatga 1346041 cgatttctga gcttcggaaa gaatacgctt atttctttcg aagcattaca aatcataaaa 1346101 attatcctta tacaagataa tgtataagga tttttttgct tttagaagga atttctcgaa 1346161 ttatagcgaa tacgtatagt aagggactga actcttatta tatgtaaggg ttttcattat 1346221 ttttttataa aaatcctata tacgaggtag atatgatgag attatcgttt aacgaagaag 1346281 aagttgagcg tgcgatgaat ttgtacagag tttttgcaag ggctttcaaa agtgtgtccg 1346341 aacatagtat ccgtgatagc aaagagcacg gttttaatcc cactgaattt gctgtactgg 1346401 aactcctgta cacaagaggc ccgcaaaaat tacagcaaat tgggtcgaga cttctgcttg 1346461 taagcggaaa cgtcacatat gttattgaca aactagaaag aaacgggttt ttagtaaggg 1346521 agcaggaccc gaaagataaa cgctctgttt acgcacattt aactgacaag ggaaatgagt 1346581 atttggataa aatttatccg attcatgcac tgcgtattgc gagagcgttt tcaggtcttt 1346641 cgcctgatga acaggaccag ctgatcgtcc tgctcaagaa agcaggcata cacagccagc 1346701 atttgctgtt tcgttaacta ttctacactc tctatttcag gagagtgttt ttttgtttcc 1346761 atatgattct ttttaaaaca tctttaatct tcctatcaga catttcgcca aggtatccat 1346821 tgacgtgttt tttatactcc ttcatctgtt cgttcgattg aaaaaatgcc gcgatatact 1346881 cttctgcttt ctgcatgtcc cagtttctca tatctgtgac gagtttcctt tcatgtagaa 1346941 ggtttaaatt catttcctcc tgtcccggca gtgcatgata aataaatacc ggaagccgtt 1347001 tctgtaagca ttcactgatg gtcacgcctc cgggtttagt catgatgcct gtcgcctgtt 1347061 cgtacaaacg gttcatctct gctttgctgt gaaggtaagg aatcgcctca atcaaggggt 1347121 ggtgtaaact tttgacatag gagtagagct tttcgtttct gccgcataat attttgtata 1347181 agatctttcc gcctggcgac agttcctgca cccattttaa aatcccaccg acccccatac 1347241 tgccccctgt gatgatgatg gtatatggcg ggtggtgctg caaggtatct gctgattcca 1347301 tttcaaaatt ttggtgaact ggaatgccgg tcaagtatat gttgttctga tcgataccct 1347361 ctgatattag ctgcttcttt acttccgtgc tcggaacaaa atggtaatca atgttcttcc 1347421 gtccccataa ttgattcacg aaaaaatcag tgtatacatt cacaaccgtc agattcggat 1347481 attcaggctt tagtcggttc agcagataag aaggcagcgc atgtgtgcag aaggcgatat 1347541 caggctgttt ttcttggagg atgtgcctca tttgctgtgt gaacagccat tcgtacatga 1347601 aatagcgttt gtcatgctga aattctccgc aggcgaggag cctgtaaatg ccgctgtacg 1347661 ttttcgggaa atattgaatc cattttaaat aagccacgga ggacaatttt tctaaccgcc 1347721 tatacgaatg tgaaaagata tcaatctttt cagctgccag cccttgagac tctaattcag 1347781 cctgcaatgc atcagccaca tgatgatggc cggtggaaat gcttaaaaaa ggaaaaatga 1347841 gaatgttttt catgacagtc ctcctaaaaa aatatggcaa ctatattttg aggagaacgt 1347901 tcacaaaata taagggtgtt tttgatcata aggaaggtga aaagatgaaa acttgtttcc 1347961 tttccatatg gagagtggtt gatccgattt atttcttttt ttcaaggcta agcttgattg 1348021 acaacgatca aaaaagcgtt tttcgagtca ggctgacgaa gtacaaagga catcatgtcg 1348081 tgcttagcga cggaacgcat ataagaaaaa atgatgtgct cgttaaaatc cacctgcata 1348141 acataaagct gatcagggag ctgcaaagca ttgagagcgc agtcagaaag ggaatcatta 1348201 tttatcagaa agtatatcaa tcgatgccgc ttcttcttga ctatatcaac aatcataaaa 1348261 aaagcgagaa aatcaaagga atcattggga ttacaatgct tgacaaaggt gtggaaaggc 1348321 tcggctttga tgtgatcacc ccggtgaacc ctttttacag atgctttaaa aaagtgtctc 1348381 atgtgccgat tttatatttg acttcaaagc ctgtgagctt gcggcattta ccgaattcat 1348441 cctatttgtt tatctcaaaa gaaaagctgc agaaaaccta tcaaaaaaaa gactgatgcc 1348501 tcggtcagca cagtcttttt tgattaaatc tgatgaaatg tcacttcagg gcggcttccg 1348561 acacggatat ttacgccggt ttgtcccaag ccctcgctga tataaaatgg tttatcgtga 1348621 tgataatgaa ggcctttaat catgttcatt cgcacgagct ttcccatttt caccaaatga 1348681 tacggttttg gccagtgaat ttgcccgccg tgaaaatgcc ctgacagcag gtaatcataa 1348741 tgaacatctt tcatatccag aataatattt gggtcatgtg ttaagacaag atgatagcca 1348801 ttttccagac tttgataaga gccggtgata ttactccgat tcgtactgta atcatcaatg 1348861 ccgataatat tgactggtcc tgcagccgtc tcgattcgaa catgttcatt ttgcagcgtg 1348921 atacagccgt tttcctctaa aactcgcttc aatctctgaa agtcctcttc tttcaataca 1348981 taatcgtggt taccgaacac cgcgtacatt ccatatgcag gctttagctt ttgcaaggcg 1349041 ttcaagtaac ctgccagttt cggaatatta cgtttccgat caagaaaatc cccggtaaga 1349101 gcaatgatgt ccacaggctg atcttttgtt aaatgataca gctcctcagg tgagactgaa 1349161 atgttttcca agtgaagatc agataaatga aggatattta atttttttct ggctggaagg 1349221 ccgtcttttt ggtcgattga aatggtgttg actttcacat cttttgtatt gcggttcgct 1349281 ttatatagaa atggcacaaa tacgagtatg gccaatgaaa gtaagattgt aaacaaaata 1349341 tatcccctcc cttctatcag tatagtaagt gatcaagccc tatggatagc gggaattaat 1349401 gggtagagac aggttgaaaa acggattgtc atatgatgaa tgatttggaa gggaaaaggg 1349461 ataataaatt ttgacacatg aggcagaaca tgccgacgga gtcagaataa caaatggatg 1349521 tgtaagcaat gttacgattg atgagacaac aaaaaaaaga aacatattat ctctggatcg 1349581 cattatttct tcttttattg tatgtatccc cgctttttat tttaaaggaa gatgcccata 1349641 tccgggtcca cgataattta gattccaaca tcgcttggta caaggttctg gccgatagcg 1349701 gagaaatcgt cggcaaggtt gacgctgcca ttccgcaaat cattaacggg ctgccccggg 1349761 atgcctttgg caccgagtgg agcggaattg tttggctcca tgctttcttt tcttccatga 1349821 ccgcctatgc aataagccag acggttacaa gagttgtcgc tttttttgga atgtatgtgc 1349881 tgctgaagaa acatataatc ccggaaccaa aagcggcttt catccgaatt ggcgtatcgc 1349941 ttgcatttgc cttaacaccg ttctggcctt cgggaatgct gagtacgctt gggtaccctt 1350001 tggcactgtg ggctttttta aatatccgaa aaggggatat ctcatggaga gagtggctga 1350061 cgctgggctt gctccctcta tactcaagct ttgttctagg cttcttcttt ttcctggcag 1350121 ggatggcgtg tttttggctg tatgatgcca ttacaaaaag aagatggaat ttgatgttct 1350181 taggcagtat tgcatttatg acgagtatct atcttttcgt tgaatatcgg cttgtctatt 1350241 cgatgctgtt tgagcacgca ccgatgcatc gtatcgaatt tatctcatct aggcatgacg 1350301 tttggcattc tcttcgacta tccataaaaa actttgtcta tggccataat catgtgatga 1350361 ccgttcatac cgttgtcatc cttccgatcc tgatggtcgt atttgctgct ctgctgttca 1350421 aacgaaatcg gacaaagcca gaaaatgttt atctgttttt atgtgtgctt aattacgggt 1350481 tgtcattatg gtatgcgttt tggttcaaca aaatttgggc tgttccaaag cagaaatttg 1350541 cttttttagc agaatttaat tttgcccgtt ttcattttct tcggccgctt gttatatacg 1350601 tgagctttgc gcttgcttta tatctcattt ggcggatggg gaaaggatgg aaatggcttg 1350661 tgtacgccgc agtcgctgca cagctgatgg tgttggcgcc ttttaatgaa gaatatacgt 1350721 atggtgttca ttacaacgcg ccgacattca gggagtttta tgcatcagag caattcaaag 1350781 agattaagga atatatcgga cgtccgcaag attcgtatag ggtggcgagc atcggactgc 1350841 atccgtctat cgcccaatat aacgggtttt atacgttaga tacgtataac aatctgtatc 1350901 cgctctcata taaatatgaa tttagaaaaa tcatcgaaaa agagctggaa aaaaattctc 1350961 ggctgaaaca atactttgat gaatggggca gccgctgcta cctttttgtc gatgaactcg 1351021 gtaaacgata tgatttcaaa aagaactcga agaaaacgat caacaacctt caattaaata 1351081 cagatgtatt taaaaaaatg ggtggacggt acattttttc ttcagttccg atcatgaatg 1351141 ctgaacaaaa ccatctcgcg ctcgtaaaga cgtttgacca taaagattcc gcctggcgca 1351201 tttatttata tgaaacaaga taaggaggat atcgattgaa acagtcacag ccagtattaa 1351261 ccatcgtcgt cccgtgtttc aatgaagagg aagtgtttca agaaacaagc catcagctga 1351321 cagaggttgt agatgattta attgaagaaa aattaattgc tgaagacagt aaaattctgt 1351381 ttgtcgatga tggcagcaaa gaccgcactt gggctttgat tgctatggag agcataagaa 1351441 acaagaaggt taccggctta aaattagcct gcaatgtcgg ccaccaaaaa gcgcttttag 1351501 ccggattgca taaagcgaag aataggtcag actgcgtcat ttcgatcgat gctgatcttc 1351561 aggacgacat ctctgtgatc cgggatttta tgctgaaata tcatgagggc tgcgagatcg 1351621 tttacggtgt acgccggagc agaaaaaccg ataccttttt caagcgcacg accgcgttag 1351681 ggttttatcg tctcatgaat aaacttggga ttaaattaat ttataatcat gctgattttc 1351741 gtttaatgaa taaaaggtcc cttgaagagc ttgagcgtta tccggaagcg aatctgtttt 1351801 taagaggtat tgtccccatg atcggcttta aatcggccga agttttgtat gaccgcaagg 1351861 aacgctttgc cggcaaaacg aaatatccgc tgaaaaagat gctatccttc gcttttaacg 1351921 ggattacttc attcagtgtc gcaccaattc gattctttac gcttttaggg tttgttttgt 1351981 ttttcctcag cgctgtggca gggattggcg cgtttattca aaagctgctc ggccatacga 1352041 atgcaggctg ggcgtctctt atcatatcca tttggttttt gggcgggctg caattgatgg 1352101 gaattggaat catcggagag tatattggaa cgattttttc tgaagtgaaa agacggccga 1352161 aatacgcgat tgatattgat ttgtataatg aacagctgag cccgcttcag cgccaggaaa 1352221 aagagcggtt agaaaaaaag tacagttaaa cacggaaaga gctgacttca ttagtcagct 1352281 ctttttcttc aactgatgca atatagcgct aagcggttcg tcttgcgggt tgcggtaaaa 1352341 atcaaaaaat gggcagccct gcttcttaat tcgatcgatg accgtatcaa ttgtaaacag 1352401 agcgggtgtt aaagatgatt gcacctcatg ccagtagagc ggggctgcaa cagtcccaag 1352461 ctcatttcct ctcgttgaat agggacagat aatcgttttt ccttctgcat gctgcaaata 1352521 atcaagatac aatttgcagt gtctgttttt aatcaagcgt tcagtggtaa agagctcggg 1352581 aaatgcattg gtgcagtact ctgcgatcag ctgcgtaaat tggcgtgttt cttcatacgt 1352641 aaatgcctcg ggagacaagg gaatataaag ctggatgcct ttgttgccgg acagcttcgg 1352701 gtacgatgtg atgccaaagg aatccaacag ccgcttcagt tcatttgcgg cctgcacggc 1352761 cataagaaag tcatctcgcg aaggcgggtc taaatcaatg acaatctcag ccggacgcct 1352821 gcttttaatg gtttgaaaag gaacgtgaaa ctccaaagca agctggttgc aaagccatag 1352881 caatgtagac atatcctcac agacaatatg ttcatggctt ccatcataga aagactgaac 1352941 aaaatccggc gcatagtccg gcttgttttt ttggaaaaat gattcgctcc tagatccatg 1353001 cggatagcgg atgacggtga cagcccggtt tttcagaaat gggagcaggt agtcactgac 1353061 ttcaatcata tactgaataa aatcttcttt tgttttttta ttcttttcaa atatgatttt 1353121 atccaggctt gtgaactgga gctttgggtg aaccggtttg gagtgtcgta tgacttgcgc 1353181 atacgtgcat tcggtccagt ccatttggaa ttcgaaaccg ataaacgata cctctcttaa 1353241 tgtgccttgg agaattgtta agtattgaac agctgcacaa atcgaaggtt caagcgtaaa 1353301 ttcgcctgag ggtgtttgat gtccgtgctg ttccataatc tcgcgtatag cgcttttttc 1353361 ctcatcacgc attccgtgcg agacagaggc aatcggtgtc attattccgt tttttaacac 1353421 cgataccgtc agaaacccgt tgttagggtt gaaccctgtt atgcaaacat aagcttgttt 1353481 aaagttttta tatttgagcc aatcggacga ccgcttcttt tcaagccatt tgctgtttgt 1353541 tttcttcgct acaattcctt ctccgtcata ttttattacc atctcccaga gttgatcaaa 1353601 atgatcataa cagggaatgg attgaatggt ttcttttgcg taaggatctg gagatgcagg 1353661 aagctttgct gcggatatga gttcacgcag cgattttttg cggtccaaat acgaaagaag 1353721 cgttacatct tctccgcttc gctctaacaa atcaaaggcg agaaagcagc acggccgcgc 1353781 gtttgccgat tcctgaatct tgtctggcct tttcaaacgc ccccgcactt gaaggtgttc 1353841 aaaatctgca cgacagggat tcaccaaaca tacgatttca ccgtcaagtg tcagcggaag 1353901 ctctttttct aggtgctgaa aggcagtttt ggcgaattgt gtgatttcag ggaaggtgct 1353961 gctgagctcc acaccatttc tgctggttaa ggtcacacct gaagaatgga tgcggagaat 1354021 acagcggtac ccatcatatt ttacttcgta acgccattct gctccgattg gcggtgacga 1354081 agttaagacc ggctgcatgg taaacgccat gcgctatgat gtgccggagg ctttttttct 1354141 agttgttttt tgttttttat ctccggctcc tttcggttca gcggcttgtg caggtgcggc 1354201 agccggtgtc tcccggttcg gccttctggt tctgtcgatg ctggcttgca gagcgcttac 1354261 caggtcaatg acatcttcac gaggtggcgc tttatcagga gtgacagccg tttctttatt 1354321 ttctagcttg tcgttgactc tttgcagcag cgcctgtcgg tacgtgtctt catatttctc 1354381 aggctcaaac ttagcagtca gttcatctat taatgtgata gcagtttgca gttccttatc 1354441 gtttacattc gattgatcag gtacacctgg gacttgagcg gcgcttctga cctcatcggg 1354501 ataatggata gactccatga cgatacaatt ttcataaacg cggagaatcg ccagctgctg 1354561 ctttgacctg attgtcatat tggcgatacc gatctttccg gttgagcgca gcgcctcacg 1354621 cagcagggta taggccttcg tcccattatc cccggggccg acaaagtagg agcggttaaa 1354681 ataaatcgga tcaatttcct gaagctgaac aaagtcaaca atctcaactg ctttctcctc 1354741 atgctcctgt tttaagcttt ttaaatcttc gtctgtcagc actacatatt ttccttttac 1354801 atattcatat cccttcacaa tttcatcagg actaagagtt ttttcgcaat ttgtgcaaac 1354861 tttctcgtat ttgattggtg cgtgatcctc tttatggagg ctgcgcagtt taatatcttt 1354921 atcttctgtg gccgcatata gcttgatggg gatgtttact aatccgaagc tgatcgatcc 1354981 cttccacatt gtatgcatat cgataaaccc ctttttttct ttagtgtgaa gagaaggagt 1355041 acgattcatg tgtagtaact tatgggtgaa aaaaagccgg cgctgttatt gcgacggctg 1355101 ttcaataatg aattgttcga attgttccgg aggtattggc ctgctgaaaa agaagccctg 1355161 caaatggtcg cagccttttt caaaaagaag ctgcttttga gctgcatttt ccacaccttc 1355221 ggcaatcacc tgcaaagaca gctgatgccc catggcaata atagctccgg taatttgctc 1355281 tgatttagga tgggtctgaa tatcgtcaat aaatgatttg tcaatcttca gcctgtgaat 1355341 cgggaagtcc ttcaaatagc taagagagct gtgaccagta ccgaaatcgt caatactgat 1355401 tctgattcct aattctgtta gggatgacaa aacctttttg gagtgattga gattgtccat 1355461 tgtcatgctt tccgtcacct ccacttcaag aagctgcgga ggaagctggt acttattaag 1355521 cgtatccttg atgaggggaa tcagatcttt agattgaaac tgtctggcgg aaatattaat 1355581 ggcgacagaa agatcatagc ctttgtcatg ccaaatcctt gcctgcttgc atgcttcatc 1355641 tataatccac tttccgatat caataataag tcccgtttct tctgcaacac cgatgaattc 1355701 tccgggcgga cgcagttgcc cgtctggtgt cacaaggcgt atcagtgctt ctgctcctgt 1355761 cattttttgt tttttcacac tgaattgcgg ctgataatgc aagacaaatc tatcgttttc 1355821 gattgcttct ctgagtacca tctcttggtt aagcttaacg gtttctttgt tgccgattga 1355881 aaaagaatag tatctgtatt tgcttttgtt tcgttcttta gccgcataca tcgccatatc 1355941 agcctttttc atcaattcaa ggccatccgt cccgtctttt ggagatatcg caatcccgat 1356001 actgacagat gtgacaaggg tgtgatcttg aattttgaaa ggttttttga atttttggat 1356061 aatttttctt gctaaaacat ctgcttcgcc tgttcctgta ttggcgtctg ttaatataat 1356121 aataaattca tcaccgccaa gacgggcgat aaatccgtta tcagggacta cagatgacag 1356181 gcgtttagct gcaaactgaa gcaattgatc accgacatta tgccctaatg catcgttaat 1356241 cactttaaac cggtttaagt caagaaagaa tacaacagtg ttataatgca aggaatgctc 1356301 gcgattcagc acctttgtta gatgagagat ggcatgcctt ctgttaggta agtctgtaag 1356361 cgaatcataa tgagccattc tatggatttc tttttctgct ttgtactgct tcgtcatgtc 1356421 tttacaaatg acataaatgc tgtctagttc ctgattgacc tcaacaggta taagcgtaat 1356481 atttaagtga aactggcctt tttcagtgat aagatcgcta tcgctgttca tcgcttgttt 1356541 atctttttta acttgctcaa aaaggcgctt aaccttcagt gatgtgtaat tcctccagtc 1356601 atgcatgctg aagccaaatt tgctgatcat ttcctcacca gcgtgattgg aagatattat 1356661 gtctccttct aatgataaaa taaaaattgc atcaatattg tggacgatta aagactgaaa 1356721 tcgctgttcg ttatccttta tgcgttcgct ctgtttaata aactttcgat ctgcatggga 1356781 actgaataac aataacgttt ggatacaaaa aataattaaa gtaacaaaaa ttgaccaatg 1356841 aaacgtttgc acctccatat ggcttccggg cggagccatg tccttatgga aagttgccgc 1356901 aagcatccct gtgtagtgca tgcccgaaat cccaatgccc attacaattg aactgacgcc 1356961 tttatagaat ataagatgct cagaatgttt ttttacggcc aagtcaaaga atatttttaa 1357021 cgagacgaaa gaggctgcaa tcgcaatgat aattgaaact gtaaataaaa taggttcgta 1357081 aataatcatt acccgggaaa tggcagacat tccgatatag tgcatagaag caatagatgc 1357141 gccaagcaca actgatccgg taagcagtct gtaatatgta agaatgtgcc ggctgacaaa 1357201 atataatgac acaaatgatc ccgaaacaga tgcgccaatg gctgccatta aaggcatgaa 1357261 ttcatattcc atcggcattt ccatatggac ggccatcatc cctacaaaat gcattgacca 1357321 aataccgaat cccataataa gtgagccgcc gatcagccaa attttacttt ttaagcctgt 1357381 attgatggtg actttccttg aaagttcaag ggaaatatac gaggcggtac aggcaattag 1357441 aatagataaa catatgagag tcgtattata tgtaacgtgt atttccaaat ggagattccc 1357501 cccgtatcgt gtgttccagt cttgttgact ctctttatta tcggctgctt aaccgcagag 1357561 tttcagcctt caaaacgata gaaatacgag ggagatctat ttttagttca actgaccgtg 1357621 aaaaatgtgt taaaatcatc ttgatgtttt ccgaaaagag aaaaatgtat gatacataaa 1357681 catgaaacaa gggagttggt ggctatcgaa gagctggtta tgtcatggat tgaagcattt 1357741 aaaagcttat cttattttgg aatatttcta gcgctcagca ttgagtttat tccggccgaa 1357801 gtcgtcttgc cgcttgcggg ctattgggta tctaaaggcg atatgacact tgctggcgtt 1357861 gttttggcag gatcgcttgg aggagtggcc ggtccgctta cgctgtattg gataggccgg 1357921 tacggaggaa ggccgtttct tgaacgtttt gggaagtatc tctttattaa acctgaagcg 1357981 cttgataagt cagataattt tttcaaaaaa catgggggct ttgtcgcctt cagcggccgt 1358041 ttcttgcctg gtatcaggac attgatttcc ataccgtgcg gaattgcaaa aatgaatgtt 1358101 tgggtgtttt cgctttatac attcattgct atgcttccga ttacatttgt atatgtttat 1358161 ctcggtgtga agctcggtga aaattggaag gcagtcggct ctattcttga tcaatatatg 1358221 cttccgatcg ggatagcgat tttggcgctg ttcctgctct acttactgat gaaaaagagg 1358281 aagaaacgca cgcactccga acaattatct gtatttttga aaaataaacg ttgacaaatc 1358341 actgcgctgc gcatattatt gacgtataaa atcatatttc ttgaaatccc aaaggggagt 1358401 agcgtccgga atgtattccg gaaacaaagt cgtcatttca tggattgtat ccatcggctt 1358461 tgttggcatg cctgaattca tgtctagcaa gacctttgcc ttatgtcggc aaaggtcttt 1358521 tttgcatggt ccggccggca taagatcgga tgaagagaaa gaaaacaact tttttgggag 1358581 ggtatcattt atggatgcag cattattatt agagtatggt tgggttcttc tcgtcttgat 1358641 cgggctggaa gggattttag ccgccgataa cgcgctggtt atggcggtaa tggtaaaaca 1358701 tttgccggag gaaaaaagaa aaaaagcgtt attttatgga ttggcagggg cttttgttct 1358761 gcgatttggc tctttatttg caatttcttt cttggtcaac gtatggcagg ttcaagcgat 1358821 tggcgcgatc tatttgctgt atatctcagc aagccactta ttgaaaagat atgtatttaa 1358881 gaaagaagac acacataaag agacgaagca aagcggtttt tggccgactg ttttaaaagt 1358941 tgaactggca gatatcgcgt ttgctgttga ttccatctta gcagcagtag cgctggcggt 1359001 tacacttcct gggacatcac tcccgaagat cggcggactt gacggaggac aatttctcgt 1359061 cattttggcc ggcggtatca tcggactggt gatcatgcgg tttgcggctt ccatgtttgt 1359121 gaagttatta aaggaacgtc caagcctaga aacagcagcc tttgtgattg tcggctgggt 1359181 cggagtgaag cttgctttat atacgcttgc ccatcgcgac atagcggttg tttctgagca 1359241 ctttatccat tctggaacat ggaagctgat attctggggt gtcttagcag caatcgcggt 1359301 ttgcggctgg tttatgtcag gtgggaaaaa acagccggag ggtgcacaaa acgaacaaaa 1359361 aaacagcacc cgtgaacggg cgtaatctga aagactctgc ttaaaagcag agtctttttg 1359421 tgtttgaagc gttttcataa gcgaaataaa ataacatttt tataacatct ttgttacaaa 1359481 aaacacgcat aaaaccccct taattcttta gaaaggcacg aaatcatgta tagaacgtca 1359541 gaatggtttg tcataattga gacattggaa atcaatattt ctttttctcc tttgcgaatc 1359601 cctatcaaat tagctatcat taatgagtag ttatagggag gaactgaggt gaaaccagtg 1359661 cttagccttt tgtttaaatt gggaaaaaag aagcaaacac ttgaaaaagc tgttgagagt 1359721 atacaaaaag gcaataaaga tctgcaaaat gaattaatac agcaatataa gccatttatc 1359781 gcaaagacgg tttcatccgt ttgtaaacga tatatagatg aaaaagacga tgagttcagt 1359841 attggactga tcgcgtttaa tgaagctata gaaaaatatt cacctgaaaa aggaaattct 1359901 ctgctcgcat ttgctgagct tattataaaa agaaaagtca ttgattacat tagaaaagaa 1359961 gccagaagcg cacaaaatat aaatatcgat ttacaggaag gagacgatca ggagtcatca 1360021 caaagcctga ttgaagccga gctttccatt gatgaatacc gccgtcagat tgaacaggag 1360081 cagaggcggg aggaaatcct ctattttcaa aagcagctca aggattatgg tttatcgttt 1360141 aaagaactgc ttgaaaattc tccaaaacac acggatgcaa ggcaaaacgc cataaaggtg 1360201 gcaatgacgc ttgttgaaca tgaagaattg gccgctatcc tgtatacaaa gaagcagctt 1360261 ccggtcaaac agcttgaaca gcttgtctct gtaagccgaa aaacgattga gagaaacaga 1360321 aaatatatta ttgcgatgtg tattatcatt acgggtgatt atatttattt aaaagattat 1360381 cttaaagggg tgctgcactc atgagaagag ggattatagt agagaaaaat aaaaaattcg 1360441 tcacgttgct gacccctgac ggacaatttt taaaagccaa aaatgatcga cacagctatg 1360501 aaatcggaga agaaatcatg cttccgagtg aaacacgcat gggcagaagg gccagctttt 1360561 ttgatttttt taaactgcgc cctttcaaaa tggggatttt tacgatgact gctattatgc 1360621 tctttatttt tatagttctc cccgtttttt ctaataataa ggcctatgcg tatatgacaa 1360681 tcgatatcaa tccaagcgtc gaaatggcgt taaacagcga ttatgaagtg attgaactga 1360741 cgcctctaaa cgatgaggga cagaaagtcg tgaatgatat agatgattgg gagaagactg 1360801 attttaaaaa ggtgattgac gatattataa ccgactgcag tgaacacggg tatgtaaaaa 1360861 aatcgaaaga aatattgatt tccactgttt atgaaaacac agaagacaat acatataaaa 1360921 aggctgtgaa aaaacagctg aatgatgtga ctgaaaaata taaaacgaca taccgcatgg 1360981 aatctctcga gtcagatatg caaacgaggg aaaaagcgaa gaaagaaggc gtctcaacag 1361041 gcagctacat caaatcaaat gaaaagaatg acaataaaga tataaaagat gactccagca 1361101 aaccatccgg ggaagaggat caaaagagtg atgaaaatga ggatgaaaac accgatcaaa 1361161 ctgacaccca ggacagcaag caaggagata atgaacagct gaatgatgcg gattccggag 1361221 accagaaaga agagaaagcg gatgaccaga ttgatgatag tgacaaagat aaaaaaataa 1361281 aggaatcaga tgaaaacaca aataccgaaa aagatgggga ccatgagcaa accccaatac 1361341 aagatcctca agataaagga aatgaaaata acggcgctga caagggccaa agccaatatc 1361401 acagggactg gaacaatggt gaacaaggca agaaccgttc ttcgtccaga agggataacg 1361461 cttcagaccg acgtaatcca aacggctaca gcagtgataa tcattcagct aaaaatgaag 1361521 attcgccgag tgcccccggc gaataaagac ctgaatttat ttagttgtgc catttaattg 1361581 tgattgtgct tgctgtacca gccgctttgt catttctccg cctacagagc cgttagcgcg 1361641 tgcgactgta tcagaaccaa ggttcacacc gaattcttga gccacttcga gtttaaattg 1361701 gtctagtgcc tgctccaccc ctggaacaac gagtttattt ctgctcgcca tctttttcat 1361761 ctcctttttc gataaagaaa ttcttaacgc gtatttagtt tgaaatatac ggggtttatt 1361821 tatgctggca attgttgtgg agaaaaataa aaccccggcc tctgagccgg ggtggcgcag 1361881 actatagaat gtctgctgtc attttatgtg cggttgcctg aatatggaat gtcaaaatgg 1361941 agaggactgt aatggcgata atctgtctga ttttaagcca ttggctgtca ttcagttctt 1362001 caaaacggtg acggagacgc tctgtctcct gttcggcgat ctcctgcaga tttgattctt 1362061 tcatagaagg agtatcttgg tgatggatgg catcaagcac atatgcgcag ctttcataat 1362121 aagcaatcgg gctgatgaca tcatcagatc tgtctgagat tgtgttaaag gccactttta 1362181 aaatagcccg tatgtgttca aagtcataaa tggattttaa atcacgtaca attaaaagaa 1362241 taactgcctg ttcaattgag tattttttgc ccagctcagg gtgtccgatc agatctttga 1362301 tatcacgctt tacccagttt tgaatcgcgg ttgactttaa cgaagtcagc tcgcataagt 1362361 tgccaagctc tacgatttca tttgtagaca gaccgtattc ttttttctgt ttttttcgtt 1362421 cgtatcttgt aagaaattca ggaatttcta gatgattggc tgctttttct gctgacatgt 1362481 tcgctgattg gacgagaatg tcgagcgggc tatgttctcc ttgtcctttt agggaataga 1362541 gcagccgcac catatcggtt cgagagagtt taaaaatgtt cattgttcac ctctttaaac 1362601 aatttgacgc ggatataggt ctatgtataa gttcaaaatt caagcgtcag caaattacat 1362661 taacatcata cgtcgaattc cttgcatttt caaatggatg ttttataatt taaatatacg 1362721 ggttcttttg aacttaaaat aacggaggtt gttatggcga aaagaatttt tctgtttatt 1362781 ctaacgaata ttttggtgct tacaacaatc gggatcgttt tgtctgtttt aagctctgtt 1362841 acaggagtcg ggacgtactt tacagctgat ggcggtatcg atccaatggc gcttcttgtg 1362901 ttcagtttag tcgttggatt tgtcggttcc tttacgtctc ttgcgatatc cagatggatg 1362961 gcaaagacga tgatgggcgt cagagtgctg aatccgaaaa aacactcgct cagctatgag 1363021 gaacagcaat tggttgatcg tgttcacaga ttaagccgct ctgccggttt aacgaaaatg 1363081 ccggaagtcg ggatttaccg ttcacctgaa gtaaacgcgt ttgcgactgg accgtcaaaa 1363141 cgccgttcac ttgtcgcagt atcgtcaggg ctgctggagc agatggatga cgcagcagtt 1363201 gaaggtgtgc ttgcccacga ggtcgcgcat atcacaaatg gtgatatggt aacaatgacg 1363261 cttttacaag gtatcgttaa tacctttgtc gtctttttat cgcgtatcgc cgcttggata 1363321 gcaagccgtt ttgtcaaaga agatctagcg ccgatcgttc attttattgc aatgattatt 1363381 tttcagattg tcttttcgat acttggcagc ctggttgtgt ttgcgtattc acgccatcgt 1363441 gaattccatg ctgacagggg aggagcggat cttgccggca aggacaagat gattcatgcg 1363501 ctgcggacgc ttaaaagcta ttcttcccgg attttggaag acgatcagac agctgtccaa 1363561 acgttaaaga ttaatggcaa gaagcgctct tcacttttct ctactcatcc tgatttagat 1363621 gagcgaatca gacggctgga agctaaataa tacaaacaca ttgttcctct gagagaattc 1363681 tcagaggttt tttattttat ccattgacta aaatcataaa aaaataagca agttaagaaa 1363741 atgtttcgta aaagccttta aaaatggacc taatatcttt agaataatta ccgtacttaa 1363801 aaagagaggc agaaggattt tacatgagat taaagtttgg aaaattgata caggccttgt 1363861 caccggccca gctgatcgca ttatattatt ttcttgcagt tactgtggcc gttatattgc 1363921 tgagtttgcc ggcggcccat aaaccggggg cggattggac gtttattgat gcgcttttta 1363981 cagctgtcag ttcagtcagt gtaacggggc tgacagttgt tgatacagct gatacattca 1364041 gcacaatagg gatttttata ttagcatttg ttctgcaatt tggcggaatc ggaattatga 1364101 cgctcggaac gttcatttgg ctgatcatgg gaaaacgaat cgggctgaaa gaacggaagc 1364161 tgattatggt tgatcaaaac caatcccagt tttcaggaat tgtcaatctg atgaagcagg 1364221 tactgtttct gatcttgtgg attgaatttt ttggcgggct gatactcggc acatatttct 1364281 taacctacta tgactcctat caggaagcct atttacacgg attttttgcc agtatcagtg 1364341 caacgacaaa cggcggattt gatattaccg gtaattcgat gattccattt cgccacgatt 1364401 actttgtgca gtttattaca atgcttttaa ttatatttgg agcgattgga tttcccgtgc 1364461 ttgttgaagt aaaggatttc ctgttttcaa agcatcggcg ttatccattt acgcttttta 1364521 caaagatcac gacgattacg ttcggctcac ttgtcttgtt tggagccatt ggcatctttg 1364581 ccctggaagc aaaccatgcg ttcgcaggaa aatcatggca tgatattttg tttttgtccc 1364641 tgtttcaatc aacggcaacc cgaagcgggg ggctggcaac aatcgatatc agccaattat 1364701 cagattccac actctttttt atttgtgcgc tgatgtttat tggagcgtcg ccaagctcag 1364761 tcgggggagg cataaggaca acgacttttg ctttgaacct tcttgcgctg tttcattttg 1364821 cccgcggcaa taaggccgta aaggtattca aacgggagct tcaccctgct gacttgatga 1364881 agtcgcttgt tgtcacgatg atggcgatcc tgctcgtttt tggcgcgaca ctcattctga 1364941 ccattacaga aaaacattcc ctgctggagc ttttgtttga agtgtgctcg gcattcggta 1365001 caaccggcct atcgcttgga attacggcag atttgagcag tgttggaaaa tgcgtcatta 1365061 tgattgtcat gtttatcggg cgaatcggca tcttgacctt cctgtatctg atcggaagaa 1365121 aggaaattga agcgaattat cactatccga aggaaagagt gattatcgga taggcaaaac 1365181 accgcatatt ttgcggtgtt ttttgattac caaaaaaaag atgtgtgcct cctgttcagt 1365241 tggagaacct aactccgaca ggtgcaattt acgctcctgc atcttaaaat gtctgaaaat 1365301 tggcgaggag gattcgtatg aagcgtaaag ctgaagtgaa tgaagccatt aaaaataaca 1365361 atacacctac cgagagcatg gaccccaatt catataagac acaatatcat gacgacccca 1365421 attttagagg ggcaaaccgc aattccaaac agggccagca gggaggcatg taattgtgaa 1365481 gaaaaaccgt catagcagag acatgcaaaa tcataaaaag cctatgaata aaaaggtgct 1365541 ggaggaagaa ttctcaagtg aactcgggga ttacaatgcc ggaaagatca tcgaaacgct 1365601 ggaagtcacc aagcctgaaa agaaaaaaga aaaaaacaaa aaacaacaat aaaaaagacc 1365661 tcttaggcgg cgtcccgctt aagaggtgct ttttctattt taaataagca tttttgcccg 1365721 ttcctctgac aaattgcaat aagcttgtca tcctcagctc aatgaatggc tgagcgactg 1365781 tcttaacaaa gttgctggag aggactgatg tcagggctgc tgttaaaagc aagaggatca 1365841 ctaagctttg atagtcagta agccaatcct caagcccgac ctgccgtaat gtcttaataa 1365901 taaacccgtg aagcagatac acgtaaaatg tccgggttcc ccatttggta aagaaatacc 1365961 gtttttgcgg aacgagcgct aaaaagctga aggttgcccc aaaggcgagt acataccagc 1366021 cgattcggga tagtccgctt accagggtaa cgtctccaaa tgaagaatac ggttttgaac 1366081 caaacagaaa agaatagtca aaatcgatgc cccagcagat gacgaatact gcggcaagca 1366141 ctccgagcgc aatttgtttg ccgcgttttg atctcaataa atcaaaatga tgtttattta 1366201 aataaaaacc gacaaggaac atcggtaaga atacgaatgt ccgtgacaag ctcagcgtgc 1366261 tgctgacaaa gtccagataa ccgatcagca cggcgattcc gcagctgaca aacagcgccc 1366321 actgctttga aagctttgaa aaaggatata ggagcaggtt ccaaaagaat aagcttacaa 1366381 gaaaccataa cgaccattgc ggatcaatcg ggttcacatt tgccatgctt tcatcttgca 1366441 taatgtaata aaagacggaa taaataattt ggaaaatcaa atacggaata atcagcttga 1366501 ccgccagctt ttttacatat cccgcccgtt taaagccttt cgcgaaataa ccggatacaa 1366561 gaataaatgc aggcatatgg aatgtgtaaa tgaacttgta gaggtagagc ataaaatgat 1366621 tatcattaat aaaggaacga aggatatgac cgaatacaac aaggaatatc aataaaaatt 1366681 ttgcgttatc gaaataactg tcccgcgatt tactcatagc atcaccttct ctttcatcag 1366741 tcactaagag attattccct gctggtacat attttaaaat aaaagatgaa aaaggaatct 1366801 aaaaaaatgc tgattgttag gtcgatgtaa agtgacggta aggatcgtag aaaatgtctt 1366861 cgtaatgtaa tgacgctgaa attttctgaa atttataggg caaatgaagg aagttcccgc 1366921 attttgtaga aatattgagg gataggtttt gaagaaggag tgtacatgca tggaaactct 1366981 tggtgtccag acaaactcgg agctgcgaga ggaactgaat cgcctcaaag aagaaaacgc 1367041 gcgactgaaa aaggaattga atcagcatca agtgattgtc aacaatacgc tcgatgctat 1367101 ttttatttgt gataacgaaa tgcggattgt tcaggcaaat gaagcaacag aaaggatgct 1367161 tcaagttgac tcggaagatt tgaaaaagcg ttctgttttg gattttttgt tttcaatccc 1367221 aaaggatgaa ctgaatcttt ccgtaaagaa gttttttaaa aaaggctttc tgtggaagga 1367281 ggttccgatc aggcttgatt gcggggcaac aaaatacata gagtttctgg ccaaaagagg 1367341 tattggtgag gatttctttt ttgttgtcat gagggacata tcttctaaga agattctgga 1367401 gcgggaattc tctatgaatg aacagctttt taaggacttg tttgacagag cagttgacgg 1367461 aatcgtcctg tttgataaag atggcggttt tattgatgca aatttgtcct tttgtaaaag 1367521 ctttgaaatc aatcataatg agctgtctca tttatctttg tatgagttca tagacagcgg 1367581 ctcacgaaaa gatttcgaca atatctggaa ggcgctcaac cgcaagggaa aagcgaaggg 1367641 ggagctgcct gtcaagcttc gttcaggagt tcaaaaacta tttgaattca cgattacatc 1367701 aaacatcatc agcggttttt atatgtccat tatgagggat atcacagaga agcggtctat 1367761 ggagctgcag ctctttaaaa gtgaggagcg cttcagagaa atctttgaaa atgcaatgga 1367821 cgccatcatc atctggtcga atgacggaag aatcgtaaaa gcgaatcaat cagcctgtaa 1367881 aatttttgag ctgccgatga atttgctgtt gaaaagaaag ctgtgtgatt ttctcgttga 1367941 ctcgcagcag aaatacagca taacgaagag gaaatacgca aaatacggag agatcagaga 1368001 agagctgctg tttcaaatgg ggaacggcca attcaaagag cttgaattta cttcaaaacg 1368061 gacaatcctt gaaaatcagc atttgacgat cttaagaaat gtaagcgaca gaaagcggat 1368121 ggaaaaggag cttcgggaaa gcgagctgaa attcagaaaa gtgttcaacg gatcaatgga 1368181 cggcaatgta ttgttcgaca atcaatacag gatcatcgac gccaacccgt tagcaagcca 1368241 tattttgggc ctgtcacatg aagagatcaa acagcacagc ctgttagata ttatttctgc 1368301 ttatgaaata gaaaatttgg catcaccggc aaggcagatt aattttgatg aaatggacaa 1368361 cgaaattcca tttttgctga gcagcggtga taacagaaaa ctcgaattct catttaaacg 1368421 gaatattatt caaaatatga acttggctat ctttaaagac gtaacagagc gaaaagaatt 1368481 ggaggagcgc ctgcgcaaat cagataccct tcatgttgtc ggcgaactcg cagccggtat 1368541 tgctcatgaa atcagaaatc cgatgactgc tcttaaaggc ttcattcagc ttctgaaagg 1368601 gagtgtcgag ggagactacg ccctttactt caacgtgatc acctcagaac taaagcgcat 1368661 cgaatccatc atcaccgaat tcttgatttt agccaagccc caggccatta tgtatgagga 1368721 aaaacatgtt acccaaatta tgagggacac gatagacctt ctaaatgcgc aagccaatct 1368781 cagcaatgta caaatgcaac ttgatttaat tgacgacatt cccccgattt actgtgaacc 1368841 gaatcagctg aaacaggttt ttatcaatat attaaaaaac gccatcgaag tgatgcctga 1368901 cggcggaaat atttttgtaa cgataaaggc attggatcaa gatcatgttc taatctcctt 1368961 aaaagacgag ggaatcggaa tgacagaaga taaattaaag cgacttggtg aaccgtttta 1369021 tacgacaaag gaacggggaa ctggacttgg gcttatggta agctataaaa ttattgaaga 1369081 acatcaaggc gagattatgg tagaaagtga agaagggaag ggcaccgttt tccatattac 1369141 gcttcctgtc agacagaatg ctgaagaaag aaggaatgat gaatgaacta ctatacgaca 1369201 gccgaaacgc cgctcggtga acttatcatt gccgaagagg aggaccggat cactcgtcta 1369261 tttctcagtc aggaagattg ggtggattgg aaagaaacgg ttcagaatac tgagcataag 1369321 gaaacaccta atcttgcaga agcgaaacaa cagcttcaag aatatttcgc aggcgaaagg 1369381 aagacattct ccctgccgct cagccaaaag ggcactcctt ttcagcaaaa agtgtggcaa 1369441 gcgctggaga ggattccata tggcgaatcc cgaagctatg cggatattgc cgctgctgtc 1369501 ggcagtccga aagcggtgcg cgctgtcggg caggctaata aacgtaacga cctgccgatt 1369561 tttgtcccgt gccacagagt gatcggcaaa aacagtgcgt taacaggata cgccggaagc 1369621 aaaacggaga tcaaagcatt tttgctaaac atcgagcgaa tctcctataa agaaaaataa 1369681 aacatatggc acgttccctt ttttcacggc cgacatatca ttttattaag ttaaaaaagt 1369741 tggtctgatg aaaaaggagg acaaagcaat tgaagccgag ccgctctgag aaacttgccg 1369801 tttttgccga actgtttgtg aaactgcata tcttatcaag cgctcaaaaa gatgaaatca 1369861 tcaatgttaa caaaaagaaa caaaaaaacc gctgactcgg ctccaaatga gcaaagtcca 1369921 gcggtttttt aatgcacctt ttctccttta aacagctgtt caatctcttc ttcatagttt 1369981 ccggtcataa tccctttttc tgtgatgatt cctgaaatga gatcatgagg tgtaatgtcg 1370041 aaagcgggat taaagacagg cacattggat ggagcggtcc gaactccgga aatctgcctg 1370101 acttcctcgg gatctcgttc ctctatcggg atatcagcgc cgcatttgac ctttgtatca 1370161 aatgtagata aaggtgcggc gacaaaaaac ggaatatcaa aggcgtttgc taaaatagca 1370221 agaccgtatg tgccgatttt atttgccgta tcaccgttct ttgcaattcg gtcggctccg 1370281 acgataacag cggaaatttg tttttccttc atcgtatggg cggccatgct gtctgtgatc 1370341 agagtgacat caatgccccc ctgcatcagc tcccaagcag taaggcgtga accttgcagg 1370401 acaggccttg tttcacaggc ataaatgtgt aatcccaaat ctttttgttt ggccaagtaa 1370461 aacggagcta gcgccgttcc atagcggctt gtcgcgattg agccggcatt gcagatcgtc 1370521 atgatcctgt cgcctttttt gaaaagctgc agggcgtttt ggccgatcaa ccggcacgtt 1370581 tcctcatcct cgacctgaat ctgaatggct tcatggacaa ggtttgtttt tgcttcattt 1370641 acggaaatcg cgttttcgac cgaatgactc agtctctcaa gcgcccatga caaattaatg 1370701 gcggtaggcc gtgagctgtt taaatattgt ttgatgtctt ccagtctgcg gcggaattcc 1370761 gtgacattgt ctgtttcaat gtctttggca gcaagcgcca gtccgaaggc agctgtaatg 1370821 ccgatcgccg gagcgcccct tactttgagc gtgacaatcg catcaaatac atcctctttc 1370881 gtcgtcagct ccaaatattc cgtctcatca ggaagctttt gctgatttaa aatggtaata 1370941 gctgtttctt tccattcaac agaacgtgga acagcaaatg aatgggtcat gaatagatca 1371001 ttcctttaca agtaacttaa ataattcaat aacatctgtt atcgttttga attccgaacg 1371061 tttttcgata aaggctgtgc cggtttcgag cgccaagcgt tttctgccga ttcgtttatc 1371121 aaacggcacg atcgtatcca ggtcagctac atgggcaagg ccgatcgtgc gtcgtatcag 1371181 ctcacagccc gcaaatccga ttgcttcttc aaaaatatgg ctgagcgtat cagtgaggta 1371241 accgtcgatg ttggcgtaaa catccagact gtccttctgc caggcttcac taaacgtctc 1371301 ttcaaacgtt tcccagacct ggttgacatg ttcatataac ggctctctgt cagccccgtc 1371361 acggctgagt gcgttcaaaa ataagttggc gataaattgc cctacatcaa agccgatcgg 1371421 tccgtaaaaa gcaaactcag gatcaatcac ctttgtttcg tgctcacttg cgaaaatgct 1371481 tcctgtatgc aaatcaccat gaatcaacgt ttctgcagac gttaaaaatg actttttcag 1371541 cttagcggct tcgattttaa cgctgtcatt attccaaagc ttttcgacaa aaggacgaag 1371601 ctcttcttca aaatcatttg tgtcatggtc gaagaaagga tctgtaaaaa caagtctttc 1371661 cgtaatgtcg catagctctg gatttgtaaa ctgtttaaca agctgttttt tcaccttagg 1371721 ttcaagcgcg taatctgatg agtagaaaag tgtttttcct aaaaattcac cgatgtgctg 1371781 cgacagatga ggatagtttt caccctcaat gagtcctttt cttgcgatct tgaggtgaga 1371841 gagatcctcc atgacggtaa ccgccatttc cgtatcagaa taaaacactc ttggaaccag 1371901 gtgaggcaca tgctcgccct gacggatgag agcgctgctt tcgattcttg cacggtcgat 1371961 tgtcagcggc cagctttctc ccaccacttt tgcatacgga accgcctgtt taatgatcaa 1372021 tgctctgtca tgttcttgat cataaatatg aaaaacgtaa tttaagttgc cgtctccgat 1372081 ctcctggcat gtcagcgtgc ttttgcttgg aaataggcca agcttcaccg ccaacgccac 1372141 agcggagctt tcatttaacg tttcgtataa aggtgttttt gtgactccca tcatcataac 1372201 ctccaattat gtaattaatt aatatgtggc cgtaaaaaag cctccttctc agagagaagg 1372261 aggcttaaca tctatgtccg cctctcttat ctctcagatc agatctgaat ggaattagca 1372321 ccgtgcctta agagaccagc gtctcggcgc gaaaaaaatg cgccccattt cacaatggaa 1372381 ttacggtcgg ttgcttttgg ggtcaaaagg ccaaatccct cgcccaactc tcgataagag 1372441 aatatattca cttgtttgac aattctaatt tatcagttga tgaacatggt aacaggtaat 1372501 ttagttagtt gtcaatatat tttttaatat aaatcttttc tgatatcatc gaaaacagga 1372561 atgctctccc gaacttctgc gctttcttga aggtcgattt ccgctcggac tatgccttct 1372621 tcccggccgc cttcagcaag tacacgtccc catggatcaa taatcaggct atgtcctgca 1372681 aattcattat ccggatttga accggtacaa ttgcaggctg cgacaaagca ttggttttca 1372741 atggcccgcg caataagcag gcttttccaa tgatcaaggc ggggaagagg ccattccgca 1372801 gaaataaaca gcacgttggc gccttttgtc gtatgttttc tgatccattc cggaaaacgg 1372861 atatcgtaac agatcaatcc agagcttttg acgccgtcaa gctcaaagta tccgtcttcg 1372921 gaaccggctg ataaatacag atgctcatcc atcagctgaa aaagatgggc ttttctgtac 1372981 tctttaatga tttgcccttc cttatccgcg atgtacattg tattataaac atcagaattc 1373041 ttcctgacag cgaccgatcc ggcgacaata tgaacaccat gtttttttgc cgttttcttc 1373101 agccagctct gagcggagcg gccgtcttcg tcagcgagtt catcaagatt ggccagatca 1373161 tatccggtcg tccataattc aggcagaaca agaacatcag catgtttgct ttctttttcg 1373221 atgaaaaatt cagccttttt tatattttcc gaaggttttc cgtatgaaat atcaaattga 1373281 agacaagata tcgtccattt catcttttta acaccccaaa tttttcttta cttttttcat 1373341 ttaaccatat atgatgatgg actatcattt caagattttt ttagaaggtg agaatagatg 1373401 aaatttgaac agtctcatgt attgaaggaa ttgcctaaac aattcttcgc ttctctggtg 1373461 cagaaagtga accgaaagct tgcagaagga catgacgtta tcaatctggg acagggaaat 1373521 ccagatcagc cgactcctga gcatattgtt gaggagatga aacgagctgt cgctgatcct 1373581 gagaatcata aatattcgtc ttttcgcggc tcataccgtc tgaagtcagc ggctgctgca 1373641 ttttacaaaa gagaatacgg cattgatctg gatccggaaa ccgaagtcgc tgtattattc 1373701 ggcggaaaag ccggtctagt cgagctcccg caatgcttgt tgaatcccgg tgatacgatt 1373761 ttagttcccg atccgggtta tcctgattac tggtcgggtg tcacacttgc aaaagcaaag 1373821 atggaaatga tgccgctcgt aaaggacaga gcgtttctcc ctgattacag cagcataacc 1373881 gctgaaataa gggaacaggc gaaattgatg tatttgaatt atccgaataa tccgactgga 1373941 gctgttgcta cttccgagtt ctttgaagat accgtgcgtt ttgcggctga aaacggaatc 1374001 tgcgtcgttc acgattttgc ttacggcgct gtaggatttg acggctgcaa gcctttaagc 1374061 tttttgcaga ctgaaggtgc gaaggatatc ggaattgaaa tttacacgct gtcaaaaacg 1374121 tataatatgg caggatggcg ggttggcttt gccgtcggaa acgcttcggt cattgaagcg 1374181 atcaatcttt atcaagacca tatgtttgtc agtcttttca gagcgactca ggaggctgca 1374241 gcagaggcac tgttagccga tcagacgtgt gtggcagagc aaaatgccag gtatgagagc 1374301 aggagaaacg cttggatcac ggcatgccgg gaaatcggct gggatgtaac agctcccgca 1374361 ggttcttttt ttgcatggct gcctgtgcct gaaggctata cttctgagca gttctcagat 1374421 cttttgctgg aaaaagcgaa tgtggcagtt gcggctggaa acggcttcgg tgaatatggc 1374481 gagggctacg tcagagtcgg acttttaaca agtgaagaaa gacttaagga agccgcttat 1374541 cgaattggca aactgaacct gtttacccaa aaaagcattg acaagacctt ataacgatgg 1374601 gataattcaa aataatttat aaaatctata ttttcttatc aagagcaggc agagggacga 1374661 gcccgatgaa gcccggcaac cgacttataa agcacggtgc taattcttgc agctagcggc 1374721 tgagagataa gattcggacg agaaacgaaa cctctttaga cgcgattgca gtttgaagag 1374781 gttttttgat atggatgaaa atgaaaggag ctctggcatg agtgagttat tagcgacata 1374841 tctcctgacc gaaccgggag ccgatacaga gaagaaagca gaacaaatcg caacaggatt 1374901 gacagtaggc tcctggactg atctgcccct tgtaaaacag gagcaaatgc aaaagcacaa 1374961 ggggcgggtg ataaaagttg aggagagaga gggaactgct gcatcagaaa aacaagcggt 1375021 catcacaatt gcctatcctg aaatcaattt ctctcaggat attccggctt tgctgacaac 1375081 agtgtttggc aagctgtccc tggacggaaa aatcaaatta atcgatcttc acttctctga 1375141 agcatttaag cgtgcactgc cgggaccgaa gtttggcgta tacggcatcc ggaagctgct 1375201 gggagagttt gagagaccgc tgttaatgag catatttaaa ggcgtaatcg gaagggacct 1375261 gagtgatatt aaagaacagc tccggcagca ggcgcttggc ggagttgact tgattaaaga 1375321 cgatgaaatt ttctttgaga ctggtctagc gccttttgaa acaagaattg cagaaggaaa 1375381 gcaaatattg aaagaaacgt atgaacaaac cggacataaa acgctgtatg cggtgaattt 1375441 gaccggacgt acggctgatc tgaaagacaa agcgagacgc gccgccgaat tgggagcgga 1375501 tgcgcttttg tttaatgtct tcgcttacgg cttggacgtt atgcaaggcc ttgcagaaga 1375561 tcctgaaatc ccagttccga ttatggcgca tccagcagtg agcggagcgt ttacgtcttc 1375621 tccgttttac ggtttttctc acgctctttt actcggaaaa ttaaaccgat attgcggtgc 1375681 tgacttcagc ctctttccgt ctccatatgg ttcggttgcg cttccaagag cagatgcact 1375741 ggcgattcat gaagaatgtg tgagagagga tgcttttaac caaacatttg ctgttccgtc 1375801 agcaggcatt catcccggca tggttccgct attaatgcgt gatttcggca tagaccacat 1375861 tattaacgcc ggaggaggcg tacatggaca tccgaacggt gcccaaggcg gggggcgagc 1375921 gttcagagct attattgatg cggtcctaga ggcccagccg attgatgaaa aagccgaaca 1375981 atgcaaggat cttaagcttg cgctagataa atggggaaag gctgaagccg tatgacgact 1376041 cgaaaacctt ttattatttg tgattttgac ggaacaatca cgatgaacga caacattata 1376101 aatatcatga aaacatttgc tcccccagag tggatggcat taaaagacgg cgtactttcc 1376161 aaaacgctgt caatcaagga aggtgtcggg cggatgttcg gccttctgcc cagcagttta 1376221 aaagaagaga ttacaagttt tgtattggaa gatgcaaaaa tcagggaagg ctttcgggaa 1376281 tttgtagcat ttatcaatga gcacgagatt ccgttttatg tcataagcgg tggaatggac 1376341 ttttttgtat atcctttgct tgaaggcatt gtggagaaag accgcattta ttgcaaccat 1376401 gcttcatttg acaatgacta tatccatatt gactggcctc attcctgcaa gggcacatgc 1376461 agcaatcaat gcgggtgctg taagccgtcg gtcatccatg aactttctga accgaaccaa 1376521 tatatcatca tgatcggtga ttcggttaca gatgtggagg cagcaaagct gtctgaccta 1376581 tgctttgcaa gggattattt attaaacgaa tgccgggagc aaaacctcaa tcatcttccg 1376641 tatcaagatt tttatgagat cagaaaggaa attgagaatg taaaggaggt acaggaatgg 1376701 ctgcaaaaca agaacgctgg cgagagctcg ctgaagtaaa acgggaattg gcagagagag 1376761 attggtttcc ggcgactagc ggcaatctgt caattaaggt tacagatgag cctttaacat 1376821 ttctcgtcac tgcaagcgga aaagataaac gcaaagagac ggttgaagat tttctgctgg 1376881 tcgatcaaaa cggagagcct gctgaaagcg ggcattctct gaaaccgtca gcagaaacgc 1376941 ttttgcatac acatttgtac aataaaacca atgccggatg ctgcctgcat gtccatacgg 1377001 taaacaataa tgtgatttca gagttatacg gagaccaaaa gaaaatcaca ttcaaaggcc 1377061 aggaaattat aaaagcactc ggcttgtggg aagagaacgc agaagtgacc gttccgatta 1377121 tagaaaatcc ggcacatatc ccgacgctag cggcactgtt tgcggaagag atttcagaag 1377181 attcaggagc tgttctgatc cgaaatcatg gtattacggc ttgggggaaa acagcatttg 1377241 aggcaaaaag agtgcttgaa gcgtatgaat ttttgttcag ctaccatttg aaattgaaaa 1377301 cactcgagca tcagctggtt aaataaaagg aggaattgaa atggctacaa ttcgaattca 1377361 tgatgaggca aatacaacga ttgaaaatca agaggaagtg gcaagctttc tggacagtca 1377421 agaggttatt tatgagcaat gggatatcac gaggcttccg gaacatctct cagagaaata 1377481 tgacctgaca gaagaagaaa aacagcaaat tcttgatacc ttcgaaactg aaattaaaga 1377541 tatctcaacc cgccgcggct ataaagcaca ggatgttatt tcattgtcag acagcaatcc 1377601 gaaacttgat gaactgcttg aaaactttaa aagagagcat caccatacag acgatgaggt 1377661 tcgttttatt gtaagcggac acggtatttt tgtcattcaa ggccaggacg gcacgttttt 1377721 tgatgtccgt ttaaaccctg gagatttaat ctccgtgcct gagaatatcc gccattactt 1377781 cacgcttcag gaggaccgca aagttgtcgc ggtgagaatt tttgtcacaa ctgaaggctg 1377841 ggttcctatt tatgaaaaag acagcgtgaa tcaataagcg tgagatagcc ccgttcatcg 1377901 aacggggctt tttatattta ttgcaaacgc cacttttcat attgtgacag ttctttttta 1377961 atcagtgtcc aaatcaaacc taaaacagct gcatcgtcaa tgaatccaag accgaggatt 1378021 acgtctggaa tgatatcgag cggcatgacg atatacagga ttgcggcagt taacagcaaa 1378081 agtgttttaa cctgtgaacg agggtagtcg ccatttcgcc aatcgcgaag catctgaaaa 1378141 aaagtagtga tgtgctggat acattttttt cggtttttcc tctttaaaat cgcttttccg 1378201 cctgccgctc cgagcattat tgctttcttt ttcttcattg ggcatacctc ctgcctggcg 1378261 gcgtgtttaa gatattcttc acctgggtat tgttcttcta atcctatcaa tatatctatt 1378321 atacctgaaa aattaactta tttaatgaaa atatgtttac aaataaagta taatctgtaa 1378381 taatgcacaa taacccaatc aaacttgttt cctatttctt agcggcgagg ggtgaagtga 1378441 atgggcggtt cttctgaaca agaaagattg ttggtgtcta ttgatgaaaa aagaaagtta 1378501 atgatagatg ccgctagaaa gcagggattt acagggcatg acacgatcag gcacagtcag 1378561 gagctggatt gtttaataaa tgaatatcat cagcttatgc aagaaaacga acattcccaa 1378621 gggattcaag gccttgtaaa gaaattaggc ttgtggcccc gcagagatgt tatgccagca 1378681 tatgatgcaa ataaatagcg gcctatcaga tgcatatata aagagagagc ttttcggaag 1378741 cgctcttttt ttctggaaaa aattcatatg aaagagggaa ctaatgaagg aactggcgat 1378801 tctcattacc gaaatggtca atcaatttca tgatgctttt atttccttat gcggaatatt 1378861 tggcattcat ttaactgaca aagaaatgca tttttgggtg atcggcattt ttggcatatt 1378921 ctttttcggc gtcactcacg ctgtgtttac atggctttct aaatggagta tgacagcctt 1378981 gtcctttatc tataccgtta cagtcatcat tgtcatcgta tttgcgattg agattcagca 1379041 aaaggtgacg gggagaggga atatggagtt tttagatgcc acggaaggta taaagggttt 1379101 tttagtattt tttatgtttt ttttgctttt gaaaatgctg ttgcgtttca tcaaaatcct 1379161 tttttctgga agaccagcaa gcaaatcgaa tggcaatgcc cgatcacgaa gataaaaaac 1379221 cctcctgaca tggtcagggg ggctatgatg cggatacggg gagggtgatc gtcacctctg 1379281 tgcctcttcg cacttcactt tcaatatgaa tagagcctcc gtacatcagc acgatccgtt 1379341 tacaaacaac aaggccgaga ccggttcctt tttctttaga agtaacaaag ggaaggaaga 1379401 tgtgatccag catttcctga gaaatccctt caccgttatc cacaactttg attatggctt 1379461 ttttatctaa agctcctagg gagatcgtca gtttgcctcc ttcaggcatt gactcgaggc 1379521 cattttttgc tacatttaaa atcacttgtt taatatgatc ttttgtacat tttacgagta 1379581 agggctgctc ggttagatac tgtaattcga cttcaacatt gtatagattg ccctcagaat 1379641 aaatgatcgg cataatttct ccgataatgt cctgaagtga gttcagctcc catttttcag 1379701 ctgtcggctt gccgagaacg agaaactcac tcactatttg attgatgcgc tttatctcct 1379761 gttcgataat ggagaagtaa agctgatctt cctcaccttt atatttcttt tgcaacagct 1379821 gaataaagcc gcttatcccg gtgagggggt tacggatttc atgggctgtg ctggcagcaa 1379881 gcgtcccgat cagctctaat ttttgcgcct cgttttctga gcgctccagc tgggtctgcc 1379941 gcttcagcaa ataatacagc acgagaataa aaaggatatt cagcagaaca ataatacatg 1380001 aaagcggaag cacaaggctt ttcgacagtt cttctattgt gaccgggttc ggatagactt 1380061 tcatattcca gctgatatca tccagatatc cgctgacagg tttctgatcc tctgcatgag 1380121 aggcttgtcc gctcgcaaaa atcattttcc cgtcttggtt cacaacttca atataaacat 1380181 cagggcttag taagttaatg agatttttca aataatcaat ttgaatagct gcgacaagat 1380241 aatctgtcac attacgtttt gagtccaaaa caggcacaca aattgtgaaa attggctgac 1380301 cagtaattct gctcgaataa ctatctgaaa tgactgtctt tttagtttcc tttgctttta 1380361 taaaaaaaga tctgtcggcc aggtttactt tcgtttttaa ttcggttgtg cttgcggtga 1380421 cgtctccttt ggcattgaga aaatagagac cggaaaatct cggctctgaa tcaaaggtct 1380481 tttccaaaat tgattgcatt ttctttatat caaccggtct gtcgatggcg atggacaagg 1380541 aggtcattct cgccattgtt tctccgatta aataattgat tttgttgcgg tgaaggttta 1380601 gcaggacact tgcttcttgt ttatgttctg cagctattgt atctttttct ttttcatata 1380661 cgaaaaagct gatgacgatt gccggaatca cgaccagtat gatataaagt ttgactctcc 1380721 cgcaggcgcc ttttagtatt ttcaatttgc atcgctccaa catacacctg attagaggta 1380781 ttatatcatt gtttcttctt ctttaataag aaaaaataac caaaaaaatt agaaaaagat 1380841 gttggcaagc ttacatttta aaaaagaaga gaaatattgg aaagattttt attgacattt 1380901 tggtctttgt ttattaatgt ttctctgtaa cggtttctaa aaggatgatt gagacatgac 1380961 agaaaaatca ctgaagttat ttatcgtgct gtcgcgcgcg tatcggtcta ttaacgatca 1381021 tatgaataag catattcata agcatgggct gaatccgact gaatttgctg tgctagagct 1381081 tttgtaccat aaaggcgatc agccgctgca gcagatagga gataaaattc tcttggctag 1381141 cgggagcatc acatacgttg tagataagct ggagcaaaaa gaacttctca ttcggaaagc 1381201 gtctcctaca gacagacgag tgacatttgc gcaaattact gaaaaaggca tcggtctttt 1381261 gaacgatatt ttccctgatc acgctgctga aattgatgaa atgatcagcg tattaagcga 1381321 agaagaggta gagatgtgca ccgaaatgtt aaaaagagta ggattaaacg caaaacagtt 1381381 tcataataag taaaaaaagg aagcctgata tgtcacaagg cttccttttt tgctattttt 1381441 catttgtttc cgctgcgcct ctcggcaaaa tgagaacttc aacccgccgg tttttgcttc 1381501 ggccttccgc agttttattg gaagccaccg gtttatactc gccataaccc ttggcgctga 1381561 acacttttgc atcgagcttg gggttttcaa tcaggagccc cataaagttt accgctctca 1381621 tgacgcttaa atgccagttt gattggaatt cagaattttt aattggcata ttatcagtat 1381681 gtccgctgat aatgatattt cttggcgggt taatcacaag aagatttgaa atctcttttg 1381741 caagcggcac atcttcctta cggatggtcg cttttccaga atcgaagaag atgctgtctt 1381801 taatcgtaat cagaaggcct tcactagtca tcttcgtctc cagctgatgt tccagctttt 1381861 tatctttgat gaacttttcc acctggctct tcacattttc aagttcttct tgatcagctg 1381921 ctttttcttt ttctttcttg tttttctctt tctcttcttt ttcctttttc acttcatcga 1381981 tgccgtctga ctcgttttca ggaggagtga cactggagta gtccagtaca ccggttccgc 1382041 ctgtaaaaac ttcattaaat gattttgaga gcatttgaaa cttagctgcg tcaatcgagc 1382101 tgctcgcgta cagcacaata aacaatgcca ggagaagagt aaggatgtcg gcgtaaggaa 1382161 cgagccatga ttcatcaacg tgctcgtcct catgcttctt cttctttttt ctcgccattt 1382221 tgcgcctctc cttgttctgc aaatttcaag cggtccttcg caggaagata cattaaaagc 1382281 ttttgttcga tgactttcgg tgcttgtcct tctaaaacgg ataaaacacc ttcaatcatg 1382341 acctcacgca gttttacttc ctgttttgat tttcgtttta atttatttgc gaaaggatgc 1382401 cataacacat accctgtaaa gataccgaga agtgtggcaa caaaggcagc actgatggcg 1382461 tgtccaagct catctgtgtt atccatatga gagagagcgg caatcagccc gattacagcg 1382521 ccgagtactc caagtgtcgg agcgtacgtt cctgcttgtg taaaaatagc ggctcctgct 1382581 tggtgcctgt cctccattgc ttcgacttcc tctgtcataa tatctcttat aaattccgcg 1382641 ctttgcccgt caacagccat gctgagcccg tttttcaaga aagcatcatc tacatcctca 1382701 atgcttgctt ctaaagcaag cagaccttcg cggcgtgcaa gctgagccca ttcagagaac 1382761 ataggaatga gttcctctat tgtgagctgt ttattttcct taaataacac tcgaaacagc 1382821 gtaggcactt ttttaatttc ttttgttggg aacgcaataa cgactgctga gattgtcccg 1382881 gcgataataa ttaaaatggc agcggggttt gcaagggcgc tgaaactgac gcctttcaga 1382941 accatcccga cgctcaatgc cacaaaagca agaataatac cgattaacga agttttatcc 1383001 atagttttca ccaaatcctt ttttactagc ttgtctatgg ttaatatcgg ttttggtgcc 1383061 cggaacttta gggacattgt gaatttgttc atgaaatatt caaggaagag gcatagaagg 1383121 gagaaataaa caaaaacggg ctctccaaaa ttgaaaagcc cgggggtcta ctgaaattag 1383181 cagcttgctt gcaagctgtc cttcagatgg tattcatata atagtagaaa tacatattca 1383241 ctgtatataa acatgttcca tccctcctta aaaaagtgta aaggatgaag ggaagtagcg 1383301 cttcaggaga agggacggta atttctaagt caagagtatg aaagtataaa aaaaagcggc 1383361 ttcctaaaag gaaaccgctg attgttattt tgctcgcact ttgattttat catcttctaa 1383421 aatcacgtga aaacttgtga tctcgccatt atcaagcagc agatcggtca tttcatcctc 1383481 aacccattct tggatggttc ttctaagcgg acgtgcaccg aatgaagggt ggtagcccag 1383541 ctcagcgatt ttttctttcg cttcatctgt cacattcaag ctaatgcccc gttccgccaa 1383601 tgtttcttca agttctccaa gaagaaggct gacgattttg acaagatgtt ctttttccaa 1383661 tgagcggaac tcaataatgc tgtcaaaacg gttgaggaac tcaggtttaa agaacatgct 1383721 cagtgaatca attaatgttt gttcttcgat gacactgtca tctgattgga aaccgacttt 1383781 cgtttgtttc tcaccagcac ccgcattact tgtcatgatg atcacagtgt ctttgaagct 1383841 tacagttctg ccttggctgt ctgtcagacg gccatcttcc ataatttgca ggaacatatg 1383901 ctgaacgtct gggtgtgctt tttcaatctc atccagcaac acaatgctgt aaggattgcg 1383961 gcgcaccttc tcagttaatt gtccagcttc ctcatggccg acatatccag gcggtgaacc 1384021 gataatttta gatacggcgt gtttctccat gtattcgctc atatcgagtc ggataatagc 1384081 gtcttttgtg ccgaataatt catctgccag tgttttagaa agctctgttt tccctacgcc 1384141 ggtaggaccg acgaagagga aggagccgac tggtctgttt ttggatttta atccggcgcg 1384201 gcttcgtctt accgcttttg ccactttttg aacagcggct tcttgtccga tcacgcgttc 1384261 atgaagtttt gcttcgagtt ctttcatttt cgtttgttcg tctgcctgca gtttgccgac 1384321 agggatgcct gttttttgtt caacaatttc ctgaatgtgc tcagcttcca cagtgacagc 1384381 ggtatgagcg gaggagctgt tcagtttttt ctccaatgcg agttcttcat cacggagttt 1384441 tgccgccagt tcgtaatttt cttcttccag ggcttttgtt ttttcggctt caattgcagt 1384501 taagcgttca gcggcatcct catcattcag ttcatcaatt aacaggttgg cttttgaacc 1384561 tgcttcatct aataaatcaa ttgctttatc cggcaggtgt ctgtcctgaa tgtagcggga 1384621 tgataaagtg acacatgctt tgattgcttc atcactgaat gttacgccat ggtacgcctc 1384681 gtatttgtct ttaatccctt gcagaatgag gatagcctgt tcaattgaag gctcctgcac 1384741 catgacaggc tgaaaacgtc tttccagcgc ggcatctttt tcgatttgac gatattcttt 1384801 cagtgttgtc gcgccaatga cttgcagttc gcctctggct agggccggtt tgagaatgtt 1384861 gccggcgtcc attgatcctt ctgcagagcc tgcgccgacg agaaggtgaa tttcatcaat 1384921 gaacagaatg acattttttc gttccttcag ctcagtgatc agctgtttca ttctctcctc 1384981 aaattggcct ctgatccctg tgtttgcaac aagagatgca acatcaagca agtatagctc 1385041 tttgtttttt agtttgtttg gaacatcacc ttcagcaatt tttaaagcga gcccttcagc 1385101 gatggcagtt ttccctacac ccggctcacc aataagaacc ggattgtttt tgtttcggcg 1385161 gtttagaatt tcgatcactc gcgccacttc atcatcacgg ccgatgacgg gatcaatgag 1385221 accggctttt gcaccgtttg taatattttg agccagctca tcaagcaacc cttttttttc 1385281 gctttgtttt gctgcgctct gttctttcgg ctggaatgcc tgttcaaacg gaaatccgaa 1385341 agattgagga cccatactca ttgaaggttt acgggtcagt tcgttatagc aagtttcaca 1385401 aagaaccatc tgtttatgaa cggaatttat ttgcatgtta aggcgaatcg tcgcctcgtt 1385461 ttgatgacaa tgttgacaac gcatttgcca aaacctcctt aataatttga tcatctttga 1385521 ccaatgaaag tgaataaaaa ggtctattgg gtttgacctt ctttgactat tagtatacgg 1385581 caaacttaac ggcattcaaa ccaatatgct caaagcagac tgaatatttg actatctttg 1385641 accaattgat ttttaaaaaa ggccggtttg tttgaccaac tttgattaat agtatactct 1385701 gactatcttt gactttcaag tcttatgcac aaaaattttt gatttgttac aaagtaaaac 1385761 atgttttctt cgtcttttca aggaacttgt ctcataggtt ataaaaaggc atatatggac 1385821 aaaactgcgg ttcgttcgga gggaagaaat ggaacaatca aaagggtctg caagtcagct 1385881 tgcttttgtg tatgtcggca cagtagtcgg agctggattt gcgactggga gggaaattgt 1385941 tgagtttttt ctgaagttcg gctggttcgg ttttttcggc attctcgtca gcggcggaat 1386001 gtttacgtta ctgggggcca agctgatgat catttcaaag cgaatcaatg ccaagtcata 1386061 tcaagaaatg aacatatttt tgttcggggc gacggctggg cggattatca atgtatttat 1386121 gctgtttgtt ctccttggag ttacatctgt tatgctttca ggggcagggg cgctttttga 1386181 ggaacagctg gggatgtccg ctcagattgg gatgctcatt acaatcggtc tgagtttaat 1386241 tgtgatgact agaggagtaa aaggcatttt cggtgtcaat gtgtttgttg ttcctctttt 1386301 aatcatcttt tcaatgattg tggtggccga ctcttttata ttcagcgaat cacgaaacgc 1386361 agctcagtgg gtctggccgc atcgctggga ttggctgtta tcagcagttt cttacggggc 1386421 tttaaattta tcgcttgccc aagctgtttt ggttccgctg gcgaatgaaa tgtcatcgga 1386481 gaaagtgata aaaaaaggcg ctttaatcgg aggcacgatg ctgacgattg tgctgtccgc 1386541 gagttttctg tctttgtcga ctcttccgga tgtatttttg tatgatatac cgatggcgca 1386601 agtggtttat ctctttgcac gatctgtcca tttgatttat ttactcatta ttttcggaga 1386661 agtgttcaca tcagttatcg gtaatctata tggattagaa aaacaagtgc aaagctttct 1386721 tccagtgaaa agcaaatata tctttgcagc cattatgatc acggcttata ttacgagcca 1386781 aatagggtac ggcaggctta tttcaacgat ttatcccttg tttggctatg tgagcctggc 1386841 cttcataggc gctttgcttt gcaaaaaagc tcctcggcgg cgcagtttat aaatatatat 1386901 aatgaaacga accgtcacta tagagcgata attgatctag gaaccgggga ctgacttttt 1386961 tattgtcaag aaaaacatca ttatggtaag atagcagaag tgaaaaaatt gaagaaaatc 1387021 cgtgcgatat gcgggagagg ttctagctac accctctata aaaaactaag gacgagctgt 1387081 atccttggat acggcctttt ttatgttttt ctagagcacc ttccgaaaaa aggtgttttt 1387141 ttgcgtgaat tagctgtagc gatgtctctc gccggcgttt ttattgcgga gaaggagagg 1387201 aatcatgaaa aaagaaaaag caattgtcgt atttagcggc ggtcaagaca gcacaacatg 1387261 cttactgtgg gccttaaaag aattcgaaga agtcgaaacg gtgacttttc attataatca 1387321 gcgacattcg caggaagttg aagtggcaaa atccattgcg gaaaagcttg gtgtgaaaaa 1387381 tcatttgctt gatatgtcac ttttaaatca gcttgcaccg aatgccctga ctagaaatga 1387441 tattgagata gaagtaaaag acggcgaact gccatccaca ttcgttccag gccgcaattt 1387501 ggtattctta tcctttgcgt ctatcctggc ttaccaaatt ggcgcgcgcc acattattac 1387561 aggagtttgc gagacagact tcagtggtta tcctgactgc cgtgacgaat tcgtgaaatc 1387621 ttgcaatgtc acggtaaatc tggcaatgga gaagccgttt gtgatccaca cgcctctcat 1387681 gtggctcaat aaggcggaaa cgtggaagct tgcagatgag cttggcgcgc tggattttgt 1387741 gaaaaacaac acgctgacat gctataacgg catcatcgca gacggctgcg gcgaatgtcc 1387801 ggcatgtcac cttcgttcaa aaggttatga agaatatatg gtgatgaaag gagagcgtgc 1387861 ataaattgtt atctcaaatt tatccgcagg cccagcatcc ttattcgttt gaactgaata 1387921 aggacatgca tatctcagcc gctcatttta tccctcggga aagtgcggga gcgtgcagca 1387981 gggttcacgg gcatacgtat accgtaaata taaccgttgc cggcgacgaa cttgacgatt 1388041 caggctttct tgtcaatttc agcgtactca aaaaactggt gcacggaaac tatgatcaca 1388101 cgctattaaa tgatcatgaa gatttttctc aggacgaccg gtattcgctg ccgacaactg 1388161 aagtcgtggc gaaaacgatt tatgacaacg tacaggctta tttagacact ttggagaata 1388221 agccgacctg tgtacaggtg tttgtccgtg aaacaccgac aagctactgt gtctaccgtc 1388281 cgaaaaaggg tggtttgaat ggctaaagga attcctgtat tagaaatttt cggcccgacg 1388341 attcaaggag aaggcatggt gatcggacag aaaacgatgt tcgtccggac agccggctgc 1388401 gattattcct gcagctggtg tgactccgct ttcacttggg acgggtctgc taaaaaagat 1388461 attcgctgga tgacggcgga ggagattttt gcggagctta aggacattgg gggagatgcg 1388521 ttttctcatg tgacgatctc aggcggcaac ccggctctgt taaaacagct ggatgctttt 1388581 attgaactgc tgaaggaaaa taacatccgt gcagcgcttg aaactcaagg gaccgtttat 1388641 caggattggt ttacgctgat tgatgacctg acaatttctc caaaaccgcc aagctcaaaa 1388701 atggtaacga actttcaaaa gcttgaccac attttaactt cacttcaaga gaatgataga 1388761 cagcatgctg tcagcttgaa ggttgtcatc tttaatgatg aagatctgga atttgccaaa 1388821 actgtgcaca agcggtatcc gggaatcccg ttttatttac aagtcggaaa tgatgacgtg 1388881 catacgacag atgatcagtc actgattgca catttgcttg gaaaatatga agcgcttgtt 1388941 gataaggtag ctgtcgatgc ggagctgaat ctcgtcagag tgctcccgca gctgcacacc 1389001 ctgttatggg gcaacaaacg cggagtataa tagaaaggaa gatgaacatg acgacaagaa 1389061 aagaatcaga attagaaggt gtaacattgc taggcaatca aggtacaaat tatttgttcg 1389121 aatatgcacc ggacgtgctg gaatccttcc ctaataaaca tgtaaaccgt gattactttg 1389181 taaaattcaa ttgcccggaa ttcacatctt tatgtcctaa aacaggccag cctgactttg 1389241 cgacaatcta catcagctac attcctgatg aaaaaatggt tgaaagcaaa tcattaaagc 1389301 tgtatctatt cagcttcaga aaccatggtg acttccacga ggactgcatg aatatcatca 1389361 tgaacgactt gattgaatta atggacccgc gctacattga agtatggggc aaattcacgc 1389421 caagaggcgg aatttccatt gatccgtaca caaactacgg aaagcctggc acgaagtatg 1389481 agaaaatggc cgaataccgt atgatgaacc atgatttgta tccggagaca attgataatc 1389541 gttaattatt ccgttgtgtg atacggagtg taaaaggaag tggagtcaca gtaaaatccg 1389601 aacattcagc gttaattttc agcggaaatg tgacctggtc acagcgaagt gtgacccgca 1389661 ctaagctcaa taaaagtggg aaaagtcaca cctgaaaatg gctctactca tgggaattgt 1389721 attaaaaagt gtgacctgag gtgcaacctg aactgtgact tttatgcagt gaaaaattga 1389781 tagtacagaa gcagattaag gcgtacaatt tgtacgtctt ttctttttta tccgaaagaa 1389841 aaaatgccta tctagagatc ataggcatta aatattatta tcaatatctt catttatttt 1389901 ttggctaagt ttctgaacct tctctttaac atttgaaaca gctctttttt gaatttcatc 1389961 aattctcctg aatatagtcg atgacacttc ttattagaac ttcactttca aaattgaata 1390021 tctcatttat ttctgactgt tcttcatctg ttaggtgatg gtattgaagt tgtttagcat 1390081 ttacttcagc agctacatca atcctaactt agttgttctg gttgtacaat ttcatattca 1390141 ccttctgcat actcttgctc cgcataatag cctccccatt gacagagctc ctgcaagata 1390201 ggtttaagag attctccaag ttcagtggat gaatattcaa ccttcggcgg tacttgatta 1390261 tacatctttc tgctcacaag tccactggct tcaagctctc taagtgtttg aatcagcatt 1390321 ttctgagtta tatttgggat aatgcgcttt aattcactcg ttctctttgg tccattcatt 1390381 aaaaagtata atacaaggcc tttccatttt ccgccaataa cttcctttgt cacttcaaac 1390441 ccacagctaa attttttcat gtctaaagct ctccattcca catttattac tttttagtta 1390501 ctatatcaca aaaaagtggg tacttccgat aatgtgctta ctgaaggata ctatatcttg 1390561 taagttgttc ttcaagtact taaaggtact agacataaaa taaaattaat tctaaaggag 1390621 tgttaagtat gggtaaattt gaaggtaaaa tagcgcttgt aacgggtgga acaagtggga 1390681 ttggtcttgc tacagcacaa aaatttgtaa acgaaggtgc atatgtttat attacgggac 1390741 gtagacaaaa cgaacttgat aaagctgtta accaaattgg caagaacgta accggtgttc 1390801 aaggtgatat ttctaagctt gaagacttag acaaactata tgacattata aagcaggaaa 1390861 aaggtaagtt ggacattctt tttgctaatg caggcatcgg caacttcctt ccattaggtg 1390921 aaattactga agagcaggtt gatagaacgt tcgacattaa cgttaaagga accatcttta 1390981 ctgttcaaaa agcgttatca ctattcccgg acaaagtagg ttctattatt gtaacgggct 1391041 ctactgctgg atcaattggc aacccagcgt ttagtgtata tggagcatct aaagcagcat 1391101 taagagcact agttcgcaac tggattcttg acctaaaagg tactgaaatc cgtgtaaatg 1391161 tggttagtcc aggaggtatt cttacacctg cctacgatga gctttttggt gatgcacttg 1391221 aagaggtact ggaaaatagc agaaatactg ttccagctgg aaaagttggg acacctgaag 1391281 aagtagcaaa cgctgtatct ttccttgctt cagacgaaag cagttacttg acgggtgttg 1391341 aattgttcgt agatggcggg ctagcacagg tataatttca ctgcgcagag attacaaata 1391401 gtccccaaaa aaggttaatg gggatttact tgaagaagtc gtataaaaaa gtcgttttcc 1391461 ttaaaggaca gggaattcga cttttttata tttgaatttg attaacgttg taaattcgca 1391521 ttttcctggg gctactacta aatgacctgt aaaaaagatt acactgtgaa taaatgtact 1391581 taaagtaacg ggggctcttg acttttaata aaaaataata tccctgtcct tgtattctaa 1391641 tacttttaaa aatatttaaa ggaatcctta tgtcctgaat aaccacatag gaaaatatgt 1391701 tgtaggttgc tttctttttt tgtggggcat cccacacaag ctatctcgtg atctcacacc 1391761 tgaacgtttt ttatagacta gtaccgcgac aagttatatt acatatacat accaataaag 1391821 tagacattaa aaagtgaaag agaggatgga aatgtgtgaa aattcttttc cttgagagtc 1391881 atcccatgtg gctctatggt ttaccgaatg ggtttaggga agcaggacat accgtaatga 1391941 tttccggtcc tgtaagtcgg gaaaatataa ctgaaatgat agacgaattt aaaccagatt 1392001 taatagtatc tatgggatgg acaccagagc attcaaggga aaagcaggcc tggattcgca 1392061 acgctactaa aaaggtgaat atccctctcg tttattgggc aactgaagac ccgctgcaca 1392121 ctcaaaactt tactatcccg ttaattaaaa agatgaaacc ggattttgtt ttcacggtca 1392181 cgccttctct gtgtaaaact tatgaaagca tggggattaa agcagctcac ttagactttg 1392241 catttcacga aagtatacat caccagatta aaccattagc gaaatacagt tgtgatatag 1392301 cagtggtggc taatgcttac cctaattttc ttgaagaaca tccggaagtg ttccgttcgt 1392361 cctctttaaa aacgcttatt cgtcctctta tacggaaggg tattcgcatt gatttttggg 1392421 ggagaaactg ggaaaaaatg agtaaatata taggaagaga aattccccgc aattggatcc 1392481 atggatacct tgattatact gaagcatata aagtttacag ttcagcaaaa atcattatcg 1392541 gtttgcaaaa ctgtgaaagc caacttacac aacgcaccta tgagattctt ggttccgggg 1392601 ggtttttatt gacatcggat acaccagcag ttcgaggtaa attcaaacct ggccgcgatc 1392661 tcatcgtttc ttcctcccca aaagaaacat tggaaaaggt taaatactat ttaaatcatg 1392721 atagcgagag aaaaaagatt cagataaacg gtaaaaaggc tgtaaagaat gattcctatc 1392781 ggcatagagc cgagagaatg cttgaggtgc taaaaagcag aggaatcata agaaacttag 1392841 gggaaaccat tcattatgta gatgttctca aagaaaaata cgtgatccat catgttactc 1392901 ccggtgaaac attatcaata attgccagta agtataatgt ttccctgcag caactcatgg 1392961 agcttaatca tttcaaatca gatcaaatat atgctggaca aatcattaag attagagaga 1393021 aactgtttag aaatattaat aacaaattat tctaaaggag agtaatatga atgaagggga 1393081 aaatacctaa aataagaaat caagcgaata aagtaaaaag aacgcctcgt tatatggaat 1393141 ttcccgtgac atacgaagta tatcatgtgg aatccggcga tacattatgg acgattgcca 1393201 aatcctttga aattccggta caacaactta tgaatcttaa taagctttct tcagatagaa 1393261 tttatcctgg acaaattata aagataagag aaagataatc tttgaggttt cggaagcgaa 1393321 tcaaattgaa atgacaatcc tcattttttt atttgtgggg aacttgatat ttttggggat 1393381 gaaggggtta tgagatgttt caaatgagct attactattc tggattagga tgggacttta 1393441 ttcaacacgt tgatcaaacg aacggagtat taaatgttgt gtctcctgat tttttctata 1393501 tcagaaaaga tggatcatta cttctccgtt cagctaatcc cgatgtgatt aaagctcttc 1393561 atagaagaaa attaaaagta gttccttttc taagcaatca ttgggatcag gatttgggac 1393621 gatttgcatt aatgaaccga gttcttttag ctaaacaaat ttctcatgca atagaagaac 1393681 tggatttgga tggagttaat atcgatatag aaaaccttac agaaaaagat cggaatctat 1393741 ttacagattt tattagatta gtaaggaaaa gtattcctag acataaagaa gtatcagttg 1393801 cagtggcggc aaatcctttt ggctggacga agggctggca cggatcatat gattacgagt 1393861 atttagctaa atatgcagat tatcttatgg ttatggccta tgatgaaagc cgccttgctg 1393921 ggcctactgc aagtgtagga tgggtggaaa agtccattca atatgttctg acccaaaaaa 1393981 tctctcctca aaaactagtt ttaggattgc cattctatgg ccgctgctgg atggaaggcc 1394041 aatctgcctc tcaagccatt cccctttacc ttgttgttag taaaaaggca tagcgggaca 1394101 attatttttg acaccaagag tcaatctcca aaagctattt ttactgtcaa tcacgataaa 1394161 aaggggccgt tgccttcggg aacatataca ttatggtttg aaaatgaaca gtcactcaga 1394221 gcaaaaataa aactcgctca aaaatataat ctgaaaggtc ttggcagctg gagtcttgga 1394281 caagaagatg cgtcagtctg gaatacagtg tttaaaaata tataatgatt tatagttcag 1394341 aacaaaattc gaagataatt gcaatgaatc tctaaatgga catactgaaa ggagtttatt 1394401 acgagtgcgg gtaaaacagt gagggcattc cataggccct tctcccaaaa tgttctacac 1394461 gaggcattac attgggcttg aaatacacat tcaaacttat gttatagtac gcattttacg 1394521 gatgtgttga atttattctg cttccatgat ttaatcatac acatgctact tgatagcagg 1394581 gttatcgcat ttcattcaga attgttcagg atcgatatgg aagcgcacga ctaactagaa 1394641 ctttaaaagc atacactcat atacttcctg aatggatgct ggtttatcta aaaaacatga 1394701 tgagaattga ttgtacgcat ggtgaagcat gacttgttga taatcgacca tatggtttct 1394761 ccttagaaat gagggggttt ttacataaaa aagacgagcg aatccggggg gaattccact 1394821 cgccgctttc taatgaaaag acgggatgct ggatggcagc tcgtctgttt tattataatt 1394881 taacgaacgt atgtttgtaa aggtgtcttt tcgaatgaat tggttcatat aaccgttaag 1394941 aacagattca ttgtaaacat tcgctaaggt atgctaagat gcatggacta taaaggagtg 1395001 atatgaagtg aagacattgc ggttaaacaa tgtaacgtta gaaatggctg catatcaaga 1395061 ggagagcgag ccgaagcgaa aaattgcatt taccttaaac gttacgagtg agacttacca 1395121 tgatatcgct gtcctgttgt atgaaaaaac gtttaatgtc gaggttccgg aacgcgatct 1395181 tgccttccgg ggggaaatga caaattattc aacatcattg accaacctgt acgaaccagg 1395241 ggccgtcagc gagttctata tagaaataac ggaaatagac aaaaacgccg attcatgatc 1395301 ggtgtttttt atgtaaaaaa gctgccggcc ggcagctttt gagaaagcga atttcatatg 1395361 taaggtgtta aattgtccgt cttgcagttt tttgaataaa tgtggaaata aggaggtttt 1395421 aataggagtc tctgatgatc ttataatttt tatgattaac aactgtcaat gaatctaact 1395481 caagatcccg atagttatcc atgatcgtca catcaacgat aacagaattc tcatttactt 1395541 tttcaacaac accggttaat ccgtttttaa attcaatgac attcccaacc ttagcgattt 1395601 tcacaagctt cctctccttt aaacataata atgccttttg aaagtatttt gcagtatttt 1395661 cattgagaag taaagcgata aggagtttta tctcccttat gaattgttct gtcgctataa 1395721 agatgatata ttgattttcg tcaatagaaa gaaaaggggg gaatttttgt tgcgtcccga 1395781 agaaataaca gaaatgattg aacagctgcg caccggcgcc ataaacgaac tgagagtcca 1395841 gaaagagcat tttcttgatt tcagggccgt gttatctaaa caagatgatt ttaaacattt 1395901 ccgaggaatt gcccagcaag gcggagatgt tatctttcaa tacttagaac agccaagaag 1395961 ctgaaggttt ctcatacgtg agaagccttt ttatcatata tgacagaaca caagcctttt 1396021 attacagctg tctgtaacag gtgtaaataa aatgtaaagt accaaagatg gataaacatg 1396081 ttttaattta acaatattta tagaatttca gactgttttt ttgccattaa gcagtgagtc 1396141 atcctcttta ttccatcctg atacctcctt gggagagttg gaaaatcttt ttccgtgaaa 1396201 atgaatggat ctcttgttaa ggttatgaag tgttttttgg agcactttaa ggaggaaact 1396261 gtatgacaac gaaattcact gctctggctg tttttcttct ttgtttcatg cctgcagcca 1396321 aaattgagca tacacaagct tcactactga gcgcaaagaa gacaaaacat gaagaagcga 1396381 aatggcttac acatatagat cgaaatacga atgaatcttt cccttcactg tctgctgata 1396441 aagacaagaa aataaaaccg attaagctat cagcacacac tgaaaagaaa gagaaagata 1396501 aaccggacaa aacaaatgat gagaaagaaa catatacaca gtctgaaaaa gagttgctgt 1396561 cccgtctcgt tcacgcagag gccaaaggag aatcatataa aggcaaggtc gctgtagcaa 1396621 gcgttgtact gaacaggacg gagaaaaaag gttttcctga tacgataaga ggagttattt 1396681 atcagaaaaa cgcctttgaa ccggtcgcaa acgggagcat taaccaaaag cctgataaag 1396741 aatcgattga agctgccgaa gaagcgctgt cctcaaaaaa tagagaaaca gatgccatat 1396801 tcttttataa tccgaaaaca gcgtcagata attggattcg ttcaagaaaa atcgtagaaa 1396861 aaatcggcag acacgttttt gccgtctaag catagaagag acaatttgtc tcagctgtgc 1396921 tttttttcat ataaagagta aaaataaaat aatttttgaa cttgtctcat atgatgttgg 1396981 tagtacaaga gacaaggaga gacatcatga atcgatttgt gaaagggatc attcttttat 1397041 ccattgccgc ctttttcgct gaatgccttg aatttgtcgt caatatgatt ttggcgcggg 1397101 agcttggcga gcatgggatg gggctttaca tgagtatttt gcccacgatc tttttaatta 1397161 ttgtcatcgc gagcctggaa ctgccgatat ccatttctaa attcattgcc gagtcaaatc 1397221 ctaagcttca tgaaagcatg ctgaggcacg ctttcagaat gacagccatt tttactgctt 1397281 tttctactgc cgccgctagt attgcgcttc cgtttattcc ggtatttgat acataccacc 1397341 cgtttattaa agggattgtc atcggcttaa ttcctgttgt cgcctttact tcaatcgcca 1397401 ggggctactt tatgggtgtg cagaaaatgg ggaagatcgc aattgccaat gtgctgaaaa 1397461 aaatcatcca gctcttgtgc ttattcctct tttttcaatg gtactcattt gaattggaca 1397521 tggctgtgct gatttccttg tttgttctag tcgtgagtga tgtggtcgtg cttgtttatt 1397581 tatattcaca atttatcatg gcaaggcggg cgttatccgg ccagcagcac attcatttgc 1397641 gcggaaagga tgtaaggaaa agactgcttg ctgtttcaat tcctacaaca ggactgcgta 1397701 tttttcatgc ggttgtcaat gcaattgaac cctttttagt aaaaggagct cttttggctg 1397761 cgggcgttgc cgggacagcg gcgatcgatc aatacggaat gctggcagga gtggctgtga 1397821 cgatagggtc gttccctgct tttattgccc attcgttaat ggtcgtcatg ataccgagta 1397881 tttcggaagc ttatgcactt tctcagtatg acatcgtgtt aaaaaggctg aagcagtcga 1397941 ttttcattac attaggttac ggtatacctg ccgtctgggt catgttccag tttgcgggac 1398001 ctctcacgca tttgtttttt cactctcctg aagcgcagta ttacttgcag ctgttgtggc 1398061 cttactttct ctttcatctg tttgtcatgc cgctgcaggc gtgcttaatc gggatgggtt 1398121 ttgtgaaaga ggctttttat cacaatgtat ggagccatat cgttgcgcta agtatgatgt 1398181 atgtactggg atcaatggag aatctgcaaa tgctcgggat tatccttgga atgaacactg 1398241 gcatgattct tttgacgagc ctgcactatg ccacgatctg caaagcattg aaggtatctg 1398301 tatttcttac gggagggacc agaacgccgc gaattgaagg atgataaagg aacagcaggg 1398361 gcaagctaat tgaaaagcat gaaaggaaga ttccatgttg acgaagcgct tgcttactat 1398421 atacattatg ttattagggt tgattgcatg gtttccaggt gcggcacaag ctgaggaaaa 1398481 acagcctgct gttcccgctg tttttcttat gaaaacgata gaaggggagg acatctcgat 1398541 tccgaataaa gggcaaaaaa caattctcca tttttggacg tcatggtgcc cgccctgcaa 1398601 aaaggagctt ccacagtttc aatcgtttta tgatgcccat ccatccgaca gtgtaaagct 1398661 ggtaacggtg aatttagtga attcggaaca aaatcagcaa gtcgttgaag actttattaa 1398721 agcaaacaag ctgacgtttc cgattgtcct tgactcaaaa ggggaattga tgaaggagta 1398781 tcatatcatc acgatcccaa catcattttt gctgaatgaa aagggagaaa ttgaaaaaac 1398841 aaaaattggc ccgatgacag cggaacaact gaaggaatgg acggaagaat agctgagagc 1398901 atagactctc agcttttttc atatagagaa gaagtgaata aacattaatg ataattatta 1398961 tcaaaaagaa attaaaataa ttataattga aattctcttc gtgcgtgcta taataaagga 1399021 agacatcaag aaataactga cgataaagct gccttttggg cagcgatttt gtttttataa 1399081 gagaaatgaa gatgatttac gttctcaatt agagaggaga attcgatatg aatgaacaag 1399141 ttatcgttca acgcgacccg catgagccat tgaaaacaga caagagggaa aaaaactggg 1399201 cacagcacgc ggagcttatt gcagcacttg tatcaggcgc tcttattttg gcaggctggc 1399261 tcttatccgg atatcaggta ttatccataa tacttttctt gctggctttt gtgatcggcg 1399321 gatttgctaa agcgaaggaa ggaatcgaag aaacactcga atccaaaacg ctgaatgtag 1399381 aacttttaat gattttcgct gccattggtt ccgccttgat cggatactgg gcagagggtg 1399441 ctattttaat atttattttt tccttaagcg gagctttaga aacatacacg atgaataaaa 1399501 gcagcagaga tttaacgtct ttaatgcagc ttgagcctga agaagcgaca ttgatggtca 1399561 atggtgaaac caaaagagtt ccggtttcag acttgcaggc cggtgatatg attgtgatca 1399621 aacctggaga acgcgtagcg gcagacggta tcattgaatc gggctcgaca agtcttgacg 1399681 agtcggcttt aacaggtgaa tcaatgcctg tagaaaaaaa cacaggcgac actgtattca 1399741 caggaacggt gaatcgcaat ggctccttga cagtccgtgt cacgaaagca aatgaagatt 1399801 cgttattcag aaaaattatc aaactggttg aatcagcgca aaatagtgtt tcacccgcgc 1399861 aggctttcat cgaacgattt gaaaatgctt atgtgaaagg tgtgctaatt gcggtggcgc 1399921 tccttttatt cgtcccgcac tttgcgctgg gctggagctg gagtgaaacc ttctaccgcg 1399981 caatggtgtt tatggttgtc gcgtcacctt gtgcgcttgt cgcctctatt atgccggcgg 1400041 cgctgtccct gatttcaaat ggcgcccgca acggtatgct tgtgaaagga agcgtctttc 1400101 ttgaacagct gggctcagtg caaatgatcg cctttgataa aaccggaact gtaacaaaag 1400161 gccagcctgc cgtagagacg atcagaatag cagaaggatt cagtgaagcg gaagttcttg 1400221 aggctgtcta tgccatcgaa acgcaatcaa gccatccgct cgcccaagcc ataacggcgt 1400281 acgctgaaag ccgcggcgtg aatcagtccg gctacatatc tatagaagaa acctcagggt 1400341 ttggcgttat ggcagaagtg tcgggtgcga aatggaaggt cggtaaagca ggttttatcg 1400401 gcgaggaaat ggcagcacaa tttatgaaac aaacagcatc agatgtcatt caaagcggtc 1400461 atacaattgt atttgtgaaa aaggatgatc aaatagcagg ctgtatcgca ctgaaggacc 1400521 aaatcaggcc tgaagcaaaa gaggtcatgg aagaactgaa ccgacttggg attaaaacgg 1400581 ccatgctgac aggagatcac gaagacacgg ctcaagcgat tgccaaggaa gccggcatga 1400641 caactgtcgt ggcagaatgc ctgcctgacc aaaaagtgaa tgaaatcaaa cggttaaaag 1400701 aagaattcgg aacgattgca atggtgggtg acggaatcaa tgatgcgccg gcactcaaag 1400761 cagcggatgt cggcattgcg atgggcggcg gaacagatgt agcacttgag accgctgata 1400821 tggtcctcat gaaaaacgat ttgaaaaagc tcgtaaacat gtgccgcttg tctcggaaaa 1400881 tgaacaggat catcaaacaa aatatcgtgt tttctctagc tgtaatctgc ctgctgattt 1400941 gtgcaaactt tttgcaggcg atggaattgc catttggcgt gattggtcat gagggcagca 1401001 cgattttagt catactaaac ggtttaagac tcctaaaata aaaccagcag cctaatcagg 1401061 ctgctggctt tttatgtatc aagctttccc ttcatttttg tctttatcag atcttttcat 1401121 aactaggatg agagcgaggg tgcagcaaag gaaacccgct gcacagccta tgatagagct 1401181 gtaataataa aagcccacca tcttcatccc gataaaagga gcggaaattc ccaaaaccgt 1401241 taagagcata actgcttttc gtctgaaaaa attcatcagc aaacggaaca acccccctgc 1401301 gattgaacgt tactgtcagt atacaggaag aggagcagga aataaaatgc attagaaaat 1401361 gaaggcgtcg tgaaaggcaa acaccggtaa aacctgttac aatggaagac agaacaatgc 1401421 attgcaaatg gcagggagga acaagaagtg aatagaatac aacgcgtctc ttcatggctg 1401481 aaggaagcgg ggcatactgc cgcatttatt catacgaaag aaaatgtttt ttacttaacc 1401541 ggtttttaca cagagccgca tgaaagatta atggggttat ttatttttca agaagaggag 1401601 cctttctttg tttgtccagg aatggaagca ggacaggccc gcaacgcagg ctggaatcat 1401661 gaaatcattg gctatgcgga tcacgaaaat ccgtgggagc tgatagagaa ggctttgaaa 1401721 aagcgaaata tcagcataca tatgcttgcg gtagaaaagg attcaatctc gctgtcacgt 1401781 gcagaacagc tgaagcatgc gacgggcggg gctcaatttg tttcagcaga agaaacactc 1401841 aatcaatttc gcctgattaa agatgacaat gagattcgtt tgctgaaaga ggcggcaaag 1401901 cttgcagatt acggtgttga agtcggcaca gccgctttgc gtgaaggcat cagtgaagtg 1401961 gaagtgctcg ctcaaattga gtatgagctg aagaaaaaag gaattcaggg catgtctttc 1402021 tctacaatgg ttttattcgg agaaaaatct ggccagcctc atggaaatcc tggtacagcc 1402081 acgttgaaga aaggtgattt tgttttattt gatctcggtg ttattcttga tggctattgc 1402141 tctgatatta caagaacgtt tgcatacaaa accatcaatc cgaagcagga ggccatttac 1402201 gagactgtgc ttcaagcgga aaaagccgcg attgaggcaa gcaaacccgg tgtgagaatc 1402261 ggagatctgg atttaactgc ccgcggaatc attgaaaaag cgggatatgg tgattatttt 1402321 cctcaccggc ttgggcatgg actcggaatt tcagtccatg agtatccatc aatgagccag 1402381 gccaacgata cactgctgca ggaaggcatg gtctacacga tcgaaccggg gatttatgtg 1402441 ccagagatcg gcggcgtacg cattgaggat gacgttcacg taacaaagga cggagcagtt 1402501 gctctgaccc aatatccaaa ggatttgatc atactgtaat agaaataaaa aaggactttg 1402561 ttctcgacat cgtccttttt tatctgcatt aaataaaaaa atcatcaaat gttcgaaagg 1402621 gtttaatttc atgtttttgg ttgagaggtt ttacagcaag acagctgcca ccgagaacag 1402681 tgagacataa cccaattaaa atgaagaaac ccatgtgatc ttctcctttc agctaaaaac 1402741 acaaaaagat atctggtacg tccatatcat attgtatgaa acgcattcca gatcaagggg 1402801 atttagaaag aagggaatct atggctaata ttaaagacat tgcagagaaa gccggtgtct 1402861 ctgttacaac ggtttcccga gtcataaaca atcatccata cgtcagtgaa gacaaacgaa 1402921 aaagagtgtt tgaggcaatg gaatcattgg agtacacgag aaatattcac gctgtacatt 1402981 tgtcgaaagg attttcaaac atgattggtg ttgtcttgcc gacggttaat ctgccatatt 1403041 ttgcagagct gattgcagga atagccgacg cagccgcgga atccggggtt cacctctctt 1403101 tattccaaac aaactatgaa gtacaaaaag aaatctttgc gctgtcccaa ttaaagcagc 1403161 gccaggttga cggcctgatt ttttgctcaa aggcgcttgc tgatgagaaa ctcatggaat 1403221 gggagggccc gattttgctt tgccagaatt cagataatgc ccgcttccca accatcagca 1403281 ttcctcacca agaagcattt cggaacggct tggactattt aattgccaaa gggcacaaaa 1403341 aaatagccat ctgtttggca agaaaaaaag gcatgaacag ccattttcga atcaaagcct 1403401 acaaagaggc attggaagag atcggcgagg catttcgtga agactgggta attgagaaag 1403461 cgattacaat caatgatggg aaggcgcttt ttcataaatg gaatacgtgg aaggaaaagc 1403521 cgacggctat ttttgttgcc aatgaccaag tctcagcagg gctttttctt gaagcaaaga 1403581 accagcgggt gtcagtaccg gatgagcttg caatcttaag cgttgataac cacgaaatca 1403641 gccaagcgct tggaatcaca acgatcgata ttcagacaag ggaaatggga aagcaggcat 1403701 ttgccatatt ggaaaaaaga attcaaggac agccgattga aaggaaagtt ctggattacc 1403761 gtctcatcga aagatcgact gtttagtgaa tgcattgaaa aaaggtttga cgtgcattct 1403821 gttcgttatg tacgatatga ggtattgaat gacaaaggag ctgaggatcg tgaatgggtc 1403881 cttcacagtg aaaaaggtac tgaataataa cgtattaatt gcttctcatc ataaatacag 1403941 cgaagtcgtt ttaatcggaa aaggtattgg tttcggaaaa aaacaagatg atgtcattga 1404001 agataaaggc tacgataaaa tgttcatttt aaaagacgag aaggaacaaa agcagtttaa 1404061 aaagctcctt gactatgttg atgaaaagct cgttgatatt tcaaacgatg tcatctatca 1404121 cataagcaat aggacgaatc actcattaaa tgaacatatt cacattgcgt tgacagacca 1404181 tatcgcattt gcgatcaaaa ggcagcagca gggatttgat atgaaaaatc catttctaat 1404241 ggagactcag tcactatatc ctgaggagta ccaaattgcc aaagaagtca tagatatgat 1404301 caatgaaaaa gcgggactct gccttccgga aggggagatt ggttttatcg ctctgcatat 1404361 ccattcagcg ttgacaaacc gtccgctgtc cgaggtcaat cagcactctc agctcatggc 1404421 gcagcttgtc gaggtgattg aagactcatt tcaaatgaaa gtaaataagg aaagtgtcaa 1404481 ctatttgcgg ctgatcaggc atatcagatt tacaatagaa agaattaaaa aagaagaacc 1404541 gactaaagaa ccagaaaaat taatgttgtt attgaaaaat gaatatccgc tatgctacaa 1404601 tacagcttgg aaattgatta aaatcttgca gcaaacattg aagaaaccag ttcatgaggc 1404661 ggaagcggtt tatctgacgc ttcatctgta ccgattaacc aataaaattt cataaattca 1404721 gtttatcctt ataacgtgtt actgattcga tcaggcatga gtgattgagg gaaaaaaacg 1404781 ggaagttcat tctcgttctt ttgcgcaccc aattttgctc atgccttttt gttgtgtaaa 1404841 agggcaaatg taaacggtta aactggaaga cttacgcctg tgaattcgtt gtcatgattt 1404901 ttagctgtaa ggtcagacta gtaaaaagag gaggtcaatt cttatgttta aagcattatt 1404961 cggcgttctt caaaaaattg ggcgtgcgct tatgcttcca gttgcgatcc ttccggctgc 1405021 gggtattttg cttgcgatcg ggaatgcgat gcaaaataag gacatgattc aggtcctgca 1405081 tttcttgagc aatgacaatg ttcagcttgt agcaggtgtg atggaaagtg ctgggcagat 1405141 tgttttcgat aaccttccgc ttcttttcgc agtaggtgta gccatcgggc ttgccaatgg 1405201 tgatggagtt gcagggattg cagcaattat cggttatctt gtaatgaatg tatccatgag 1405261 tgcggttctt cttgcaaacg gaaccattcc ttcggattca gttgaaagag ccaagttctt 1405321 tacggaaaac catcctgcat atgtaaacat gcttggtata cctaccttgg cgacaggggt 1405381 gttcggcggt attatcgtcg gtgtgttagc tgcattattg tttaacagat tttacacaat 1405441 tgaactgccg caataccttg gtttctttgc gggtaaacgt ttcgttccaa ttgttacgtc 1405501 aatttctgca ctgattctgg gtcttattat gttagtgatc tggcctccaa tccagcatgg 1405561 attgaatgcc ttttcaacag gattagtgga agcgaatcca acccttgctg catttatctt 1405621 cggggtgatt gaacgttcgc ttatcccatt cggattgcac catattttct attcaccgtt 1405681 ctggtatgaa ttcttcagct ataagagtgc agcaggagaa atcatccgcg gggatcagcg 1405741 tatctttatg gcgcagatta aagacggcgt acagttaacg gcaggtacgt tcatgacagg 1405801 taaatatcca tttatgatgt tcggtctgcc tgctgcggcg cttgccattt atcatgaagc 1405861 aaaaccgcaa aacaaaaaac tcgttgcagg tattatgggt tcagcggcct tgacatcttt 1405921 cttaacgggg atcacagagc cattggaatt ttctttctta ttcgttgctc cagtcctgtt 1405981 tgcgattcac tgtttgtttg cgggactttc attcatggtc atgcagctgt tgaatgttaa 1406041 gattggtatg acattctccg gcggtttaat tgactacttc ctattcggta ttttaccaaa 1406101 ccggacggca tggtggcttg tcatccctgt cggcttaggg ttagcggtca tttactactt 1406161 tggattccga tttgccatcc gcaaatttaa tctgaaaaca cctggacgcg aggatgctgc 1406221 ggaagaaaca gcagcacctg ggaaaacagg tgaagcagga gatcttcctt atgagattct 1406281 gcaggcaatg ggtgaccagg aaaacatcaa acaccttgat gcttgtatca ctcgtctgcg 1406341 tgtgactgta aacgatcaga aaaaggttga taaagaccgt ctgaaacagc ttggcgcttc 1406401 cggagtgctg gaagtcggca acaacattca ggctattttc ggaccgcgtt ctgacgggtt 1406461 aaaaacacaa atgcaagaca ttattgcggg acgcaagcct agacctgagc cgaaaacatc 1406521 tgctcaagag gaagtaggcc agcaggttga ggaagtgatt gcagaaccgc tgcaaaatga 1406581 aatcggcgag gaagttttcg tttctccgat taccggggaa attcacccaa ttacggatgt 1406641 tcctgaccaa gtcttctcag ggaaaatgat gggtgacggt tttgcgattc tcccttctga 1406701 aggaattgtc gtatcaccgg ttcgcggaaa aattctcaat gtgttcccga caaaacatgc 1406761 gatcggcctg caatccgacg gcggaagaga aattttaatc cactttggta ttgataccgt 1406821 cagcctgaag ggcgaaggat ttacgtcttt cgtatcagaa ggagaccgcg ttgagcctgg 1406881 acaaaaactt cttgaagttg atctggatgc agtcaaaccg aatgtaccat ctctcatgac 1406941 accgattgta tttacaaacc ttgctgaagg agaaacagtc agcattaaag caagcggttc 1407001 agtcaacaga gaacaagaag atattgtgaa gattgaaaaa taagggtgtt agtacgccgt 1407061 gcttgtcaga tgacaagtac ggttgtatga tataatattg tgaagtaata aagctttaag 1407121 ttaaaaggag aatgataaaa atggcacaaa aaacatttaa agtaactgca gattctggaa 1407181 tccatgctcg tcctgcgaca gttcttgtac aaactgctag caaatacgac gctgacgtta 1407241 atttagaata taacggcaaa acagttaacc ttaaatctat tatgggtgtt atgtctttag 1407301 gtatcgctaa aggcgctgag atcacaatct ctgcttccgg agctgacgaa aacgatgctc 1407361 ttaacgcttt agaagaaaca atgaaaagcg aaggactcgg cgagtaatgc aagaattaaa 1407421 agggattggt gcttcagccg gcatcgcgat tgcaaaagcg taccggcttg aagagccaga 1407481 tttaacggtt gaaaagaaaa acatctctga ttctgaagcg gaagtaagcc gttttgatga 1407541 agcgattgca cgttcaaaag aagagctcga aaaaatcaaa gagcacgctt tgaaagaact 1407601 gggtcaggat aaagctgata ttttttctgc tcacctttta gttctcagtg accctgagct 1407661 tctgaaccct gtgaaagaaa aaatcagcac tgattcagtg aacgctgaat tcgctttaaa 1407721 agaaacgtct tctatgttcg ttactatgtt tgaatctatg gacaacgaat atatgaaaga 1407781 gcgtgcggca gatatccgcg atgtaacaaa acgcgtaacc ggccacctgc ttggcgtcga 1407841 aattccaaac ccaagcatga tctcagaaga ggttattatt gtagctgaag acttaacacc 1407901 gtctgacaca gctcaattaa accgtgagtt cgtaaaagga ttcactactg atatcggcgg 1407961 acgcacatct cactctgcca tcatggcacg ttctcttgag attccagcag ttgttggaac 1408021 gaaagctgct acaggcacga tccaaaacgg cgtgactgtt atcgttgacg gtatcaatgg 1408081 cgatgtcatt attgacccat ctgcggaaac tgtaaaagag tatgaagaaa aacataatgc 1408141 ttatttggct caaaaagctg agtgggcgaa gcttgtcaat gaaccgactg tctcaaaaga 1408201 cggacatcat gtagagcttg cagcgaacat cggtactcct gatgatgtaa aaggtgttct 1408261 tgaaaacggc ggagaagcag ttggccttta ccgtacagaa ttcctttaca tgggaagaga 1408321 tcagctgcct acagaagatg agcagtttga tgcttacaaa acggttcttg agcgtatgga 1408381 aggaaaatca gtcgtcgtgc ggacacttga tatcggcgga gacaaagagc ttccttacct 1408441 gcagcttcct aaagaaatga acccgttcct gggatataga gcgattcgtc tttgccttga 1408501 agagcaagaa atcttcagaa cacagcttcg cgcgctgctt cgtgcaagta catacggaaa 1408561 cttgaaaatc atgttcccta tgattgcgac agttaacgaa ttcaaagaag caaaagcgat 1408621 ccttcttgaa gagaaagaaa agctcgtaaa agcgggacag gctgtatctg acgatattga 1408681 agtcggaatg atggttgaga ttccgtcaac tgcagtcatc gctgatcagt ttgctaaaga 1408741 ggttgatttc ttcagtatcg gaacaaacga tttgattcaa tacacaatgg cagctgaccg 1408801 tatgaatgaa cgtgtatctt acctgtatca gccatacaac ccggcaatcc ttcgcttaat 1408861 tacactggta attgaagcag cacacaaaga aggaaaatgg gttggcatgt gcggagaaat 1408921 ggcaggagac gagattgcga ttccgatcct tctcggctta ggcttagatg agttctcaat 1408981 gagcgcaacg tctatccttc cggcaagaac acaaatcagc aaattgtcta aacaagaagc 1409041 tgagtcattc aaagagaaaa tcttatctat gagcacgaca gaagaagttg tcgcgttcgt 1409101 aaaagaaaca ttcaagtaat gtacaaaaac cagacggcct ccggcctgtc tggttttttt 1409161 cataagtaag ggtatagaag gacacaataa catggctagg agggatagta tgtcaaacca 1409221 atttaacgca ggagatactg tttatgtgat ctacagaaat ccgcacgccg ccaatgtagc 1409281 ccacataaag gaagccgaaa ttgtgcacca tccataccat gaaggcgagc tttccctgtt 1409341 tatttatgaa acctatcatc cattcgcaga ggacgatgct gtgtttgcaa gctatgaaga 1409401 agctaaatcg ctttacaaag aactgtttga tattgatccg tatgagtaac aaggaaatca 1409461 ttacaactca tatcctttcc gcctagtgag aaaagtaacg ttagtaaagg aaaaggatgt 1409521 ggcatcatgc agaacccatt tgttccgcag cttgtgtata tagaaccgag ggcgctggaa 1409581 tatccgctgg gccaagaatt acaagataaa tttgagaata tgggtattga aatcagagaa 1409641 acgacatccc acaatcaggt gcgtaatatc cctgggaaaa atcatcttca gcaatatcgc 1409701 aatgcgaaat caactttagt tatcggtgtc cggaaaacat taaagtttga ttcatccaaa 1409761 ccctcggccg aatatgccat tccgtttgca acaggctgca tggggcattg tcattactgc 1409821 tacctgcaaa caaccatggg atcaaagccg tatatcagaa cttatgtaaa cgtcgaagag 1409881 attttagatc aggcagataa gtatatgaag gagcgcgcac cagagttcac aaggttcgaa 1409941 gcatcatgta cgtcagacat tgtaggaatt gatcatctga cacacacgct gaagcgcgcc 1410001 attgaacatt ttggccaaag tgatctcgga aagctccgat ttgtaacgaa atttcatcat 1410061 gtcgatcacc tattagacgc aaagcataac gggaaaacga gattcagatt cagtattaat 1410121 gccgactatg tgattaaaaa ctttgagccg ggaacttcac ctcttgataa gcggatagaa 1410181 gcggcagtaa aagttgcaaa agcaggctac ccgctaggct ttattgttgc tccgatttat 1410241 attcatgaag gctgggaaga aggatacaga catctgtttg aaaagctaga tgctgctttg 1410301 ccgcaggacg ttagacatga cattacgttt gaattaattc aacaccgttt tacaaaaccg 1410361 gccaaacgag tgatagagaa aaattatccg aagacgaagc tcgaattaga tgaagaaaag 1410421 cgccgttata aatggggccg ttacgggatc ggaaaatata tttatcagaa agatgaagag 1410481 catgcacttc gagaggcact tgaatcctat attgatacct ttttccctaa cgcaaaaatt 1410541 gaatatttca cttaaacggg ctgttgtgat caacagctcg cttttttata aaaaacattt 1410601 ttccattcca tcaaaacgcc gtaattcaat gattctttat cctccaaata attgctgact 1410661 acacgaatag gtgaacgccc gcaacggagg agaaaggaca gcacagggtc gtttttcctg 1410721 ccttccatca catcttcaac gtactgaaca gcgctgatct cgtgtgcgta tttataatac 1410781 aaaggaatgc ggccgccgcc gagaaggcgt tccagtcttt tatcaacagt cagctcatac 1410841 atcgtattca tcagccattt tccgattcca agctttcgat aatgaggaga aacagaaata 1410901 tccactacat ataaagtatt tccatgaggt tcatgatttt taatcgatcc gttgtcagtt 1410961 gcttgtgccc atgtatgatc aggagaatca ggctcaaatt gtacaataag agcagtcatg 1411021 gaaccgataa ttctgccatt gatgagcgcg cataaagcgc cttccggaaa ggttttgata 1411081 tggctggcaa gctggtcctc tgaccacagc aattcctggg gaaacggagg agggaaacat 1411141 tcttcttgaa gagaaatcag cctctcgatg tcagtctcag tgtagtttct aatggtcaga 1411201 gcctcaaatt ttctgccgtc atgcacatac atttgtttta gtatgatcat cactctcctt 1411261 atgttgtttc attataacga agattgaatt ttcagtaaat atattccgat tttcttataa 1411321 tttatttttt gattattcat ttttcaaacg aaagggccga tatagaaatt aggaggggat 1411381 tggtttgttt aaaaaacttc acatgaagat tgctgttttt gtttcgatta tgttaatcat 1411441 cacagttgtt ctcttaatgc tgtcttctta tttgacgcta aaaccgatga ttacagagga 1411501 tgggaaaaat acaactcaaa acgtgacgca gtcacttgaa caaaatattg aattgcaatt 1411561 aaagagttat gccatttcgt tatcaagatt ggctaatggg gaattaacgc atacatttgt 1411621 aacgaaacca agtaaagaag cttctcggct gtttcacgat gacattaagc aaatcaaaga 1411681 caacgatgat tatgttgcga tggcttacat aggcaccgca aaaaaagaaa tgtttacata 1411741 tccaaaagcg gatttcgctg aggattacga tccaacatca agaccatggt ataagcttgc 1411801 agctgaaacc ccggatcaag ttgtttggac ggaaccttat aaagatgtcg tgacaggaga 1411861 catgattgtt actgcatcga aagcgatctt agacaggcaa aaagtgatag gggttgccag 1411921 ctatgacttg aaactctctg ctatccagag tatggtcaat aaacaaaagg tgccttacaa 1411981 aggatttgcc tttttagctg atgcgagcgg caatctttta gcccatccgt caaatcaagg 1412041 aaaaaatata tcaaaggatc aaacactgca aaccatcgca tccgagaaaa aagggataca 1412101 agatgtgaat gggaaaatgg ttgtgtacca aacgattggc gagacaggct ggaaggtcgg 1412161 aacgcaattt gataccgatc aattaatgtg gatttcagat aaaatgaatc gggccaatct 1412221 ttggatatca ttgattgcgc ttatcataac aattattctc agctacttcc tggccaaaac 1412281 gataaccggt ccgatacagc agctgatcgt aaaaacgaaa gctgtttccg caggcgattt 1412341 aacagtgcgc gcggaatcaa aatctaagga tgaagtcggt attttaacaa gagatttcaa 1412401 tctgatggtt gaaaatatga aggaaatggt tgagcaagtg agactctctt cagggaaagt 1412461 atctgacacc tctgaacaac taacggctgt ggctgccgaa actaatgaaa caagcggaca 1412521 aattgcaaaa gcgattgaag aagtagccgc aggggcatcg gaacaggctt ctgaagttga 1412581 aaccattaat gaaaaatcgg aaagcctgtc aacgaaaatc aggcaaatcg ctgaggaggc 1412641 aggcggaatt aaagaacgct caaaatcgtc cgaggatgca agctataaag gacttgacgc 1412701 gctcggccag ctgctgatga aatcaaacga agccaatatg gaaacgaaaa aggttgaaac 1412761 gatgctgctg gatttggaaa atcaaactaa gaatattgaa gaagtcgtta cagcgatttc 1412821 aaacatatct gatcaaacca acttgcttgc cttaaatgcc agtattgagg cagccagagc 1412881 cggagaaagc gggcgcggtt ttgccgtcgt agccgatgaa gtgcggaagt tagctgagca 1412941 atcagccctt tctacaaagc atatcagcga gactgtgaag cttatccagc ttgagacaaa 1413001 agaggcctct cacgcgatgg ttgaggcaag cagaatgaat gatgaacaaa acagtgcaat 1413061 tcacgaaact ggagaggtat taaatacgat aactgcagaa atgcagtcac tggtacaagg 1413121 tattgatcac atttacgcgg aaattcaaag aatgagtgaa gaacagcttg cgatttctga 1413181 agccattcaa agcatttcag ccatatcaca ggaatcagct gccgcagcag aggaagtgaa 1413241 cgcatcaacc gatgaacagc ttgtcaccct tgataaagtc aaacactcaa cggaaacact 1413301 aaaacatgca agccaagagc ttatgaacac aattgcaaaa ttcacattgt aatccaatta 1413361 catccccaaa catcatttgt tttggggatt ttttatttta taagatgaat agatatggta 1413421 gtctagaaaa tgaaggaaaa atgataaatt ttaactaaaa tctaaacgaa acatctggga 1413481 ggaatgacct tgaaaaaaac aattggtttt atcggtcttg gagtaatggg aaaaagcatg 1413541 gcatcacata ttctcaatga cggccatcct gtattggtgt acacccggac aaaagaaaaa 1413601 gcagaaagca tacttcaaaa aggcgcgatc tggaaagata cggtcaaaga tctttcgaaa 1413661 gaagcggatg ttatcatcac aatggtcggc tatcccagtg atgttgaaga agtgtatttc 1413721 ggaagcaatg gaattattga aaacgcaaaa gaaggtgcat atcttattga tatgacgaca 1413781 tctaagcctt cgcttgcgaa gaagattgct gaagcggcca aagaaaaagc attgttcgct 1413841 ttagacgctc ctgtttccgg tggagacatc ggtgcacaaa acggaacact cgcgattatg 1413901 gtcggtggag aaaaagaagc ttttgaagcc tgcatgccga ttttctcttt aatgggagag 1413961 aatattcagt atcaaggacc ggctggaagc ggacagcata ccaagatgtg caatcagatt 1414021 gcaattgcag ccggtatgat cggtgttgct gaagcgatgg cttatgccca aaaatcaggc 1414081 ctagagccgg aaaatgttct gaaaagcatc acaacgggcg cagccggaag ctggtcattg 1414141 tcaaatcttg ctccccgtat gctgcaaggc aactttgaac cgggatttta tgtgaagcat 1414201 tttattaagg atatgggaat tgcactagag gaagcagaat taatggggga agaaatgcca 1414261 ggcttgtcgc tcgcaaaatc tttatatgac aagctagctg ctcaaggtga agaaaacagc 1414321 ggaacacaga gtatatataa gctttgggtg aaataaaaaa agattgcctg tacgaaacag 1414381 gcaatctttt tttattattt tccgatgaat tgttgtgtcc agatgcttcc agactcaacg 1414441 taaccaacac cgatgtgagt aaagttaggg tttagaatgt tttttctgtg tccttcactg 1414501 ttcatccaag cttttactac ttcttctggt gtcttttggc ccttcgcaat gttttcacct 1414561 gctgttttgt agctgattcc gaaagatttc atcatatcaa acggtgagcc gtatgttggg 1414621 ctttggtgat caaagtagtt tttgtctttc atatcctgag attttgcgcg tgcagatttg 1414681 cttaacgttt catcaatttg aagcggtttt aagccttgtt tttgtctttc tgcatttgta 1414741 agttcaacaa cttttttctc atatgcactt acagatgaag gtgcagacgt tgttgtgttt 1414801 gttttttcag cagttgcggg tgctttagaa gcagtgtttt gatcagcagc tgctttttca 1414861 gtagtctttt gtgcaggttt tgccgtttct gtcttttgaa catcctgaac tttcacgtta 1414921 gattgcttcg catgtttttg aagaagctgc ttcatctctt tttcgtttgc agcgtttaac 1414981 gttttgatat ttgtgttaat atgcagtttt ttcactgcat cgttaagtga catgttttgt 1415041 actgtgttcc ccgtttttac tgtaaccaca ggctggcagg agagttcttt cgctgatgct 1415101 tgctgtacgc ccccgaatgt gaataatcca accgcagcgg cagcagataa aataaatgct 1415161 ttcttcatta gttcgtaacc tcctagagtt gtttgtttct acagaaaaat cataacatag 1415221 cttttttgtc ataaagattc cagcactttc ctttgacaaa tagagattgt cattttcgta 1415281 aagtaaatcc gttgaatcac taagaataag ggaatcagcg gtatatatga ttttatcgta 1415341 ccgttacata gcttcctttt ttttgaaccg ttagttatat tttaatgtgt ttttatattg 1415401 acagcttttt ttactccttt tcgctgtaac aactattaca aaggtgttac aattaatctc 1415461 agtatatgta aatatattga atgatttgag aggggtaacc agaagtgact gaaataggac 1415521 gtgaaccaaa gaaaaagagc aaaggaaaca gagcaatcag aatgaacctt tttttcctag 1415581 ctgtctttgt tctattcact gcattaattt ttaagctcgg ggttgttcaa attgttgaag 1415641 gcgaacagca tgaagaagac gctgagaaat caaatgcaaa aacagcttac tatcctgcgc 1415701 ctcgcgggaa gatgtacgac agaaaccaga aagttgctgt cgacaaccag agcgttccag 1415761 aaattgtgta tgtatcaaca tctagcacaa aaacagaaga taaaatcaaa acagcgaagc 1415821 ggcttgcttc tttcattcat attgataccg aatttttgaa ggaaagggat cttcgtgatt 1415881 actggatcgc agctcatccg aaaaaagccg ccgctctgct taaggaatca gaaagcaatc 1415941 tgaaaggaga ccaggcttac aagcttcaaa tagagcgtgt tccggatcaa gaattaaagg 1416001 ctattcagca agatgacgaa gaaatggaaa ctgctgcgat atatacaagg ttttcaagcg 1416061 gaaatgctta cgaacctcaa atcgtaaagg caatgaatcc aaataagagc aatagcaatg 1416121 gaaaaaacgg agcgctgctt gatgagaaga aaaactcctc gcaaagacca aaaaatgact 1416181 taacatatga tgaaatttcc attgtttctg agcatttaga agaacttccg ggaatcgata 1416241 tcgtaaacga ttggacacga aaatatcctt atgacaaaac cctttattct gttttcgggg 1416301 gcgtcacgac acctgatcag ggcctgctga gcgaccggaa agatttctac ttaacaagag 1416361 gctatgcgaa taatgacagg gtgggaaaaa gttatttaga gtatcaatat gaagaatatt 1416421 taaattcgca taaagaaaaa gtggaatacg tagaagataa taaaggaaat gtcgtcagcc 1416481 aaaaaaccat tgataagggc agcaggggat acgatcttca gctttctttt gacatggagc 1416541 ttcaggcaaa ggtagaaaag atcattgaag aagaagtaag aaacagccgt gcacgcggaa 1416601 attacatgct tgacagagcc tttgccgtaa tgatggaccc gaataacggc gatattttat 1416661 caatggcagg gaaaaagata gatttaaaaa ccaacaaaat tgaagattat gcgatagggg 1416721 catttaccac ccaatatgaa atgggatcag cagtaaaggg ggccaccgtg ctagccggct 1416781 atcaggacgg gatcccgcat tataaatatt atatcgatgc tccaatgctt ttaggaacga 1416841 atcttataaa aaaatcttat actaatatgg gaaccatcaa tgaattaacc gcattgcaaa 1416901 aaagttcaaa cgtatatatg ttcaatgttg ccatgcatat tgcaggcgta acatacaagc 1416961 cgcatggatc tctcccggct gatcagaacg atctactgaa aatgagaaac tattacagcc 1417021 agtttggtct gggagtaaag acaggtattg atctcccgca ggaatcagcc ggaatgcaaa 1417081 ccacacctaa aactgtagga ggattaattt tagacttagc aattggccaa tacgatacat 1417141 acacaccgct tcaaatggct caatacatct cagtaatcgc caatggtggc tatcgtgttc 1417201 agcctagaat cgtcacaagt attcataagc caggaaaaaa agaccagctg ggtaaggcga 1417261 ttgaacatag gaaacctaaa gtactcaata agattaataa ttcagagagc gatttgaaac 1417321 aagtacaaac aggcatgaaa ttagtcactt cttcagggac agcaaaaaat acgtttacag 1417381 aagatgtatc agggaaaacg ggaacagcgg aaacatttta ctacggcacg aatcgcaact 1417441 ggtgggggaa aaaaacatac aatctgactt ttgtcggcta ttacccgtcg aaaaaaccaa 1417501 aagtggcctt tagtgttgtt gttccatcag tagatgatga tgataagatc aataaaatta 1417561 ttgccaaaag agctatccac gcctacgcag agctcgaaaa aaaacacagt aaaaaataaa 1417621 aaacagggtg cacaactaaa agattgtgtg ccctttcttt tattcaaaaa ttgacgttca 1417681 ccataagaat agaaggagaa tactcatttt ctagcgaatc atactaggta aaagtcaatc 1417741 tgtatatgtc gaaacacgat gatcatgcaa aggagggatt ctgtggaaca ggatacgcag 1417801 catgttaaac cacttcaaac aaaaaccgat attcatgcag tcttggcctc taatggacgc 1417861 atcatttata tatctgccaa ctccaaactg catttgggct atctccaagg agagatgatc 1417921 ggatcattcc tcaaaacgtt tctgcatgag gaagaccaat ttttggttga aagctatttt 1417981 tataatgaac atcatctgat gccgtgcacc tttcgtttta ttaaaaaaga tcatacgatt 1418041 gtgtgggtgg aggctgcggt agaaattgtt acgacaagag ctgagcggac agaacgggaa 1418101 atcattttga aaatgaaggt tcttgaagaa gaaacaggcc atcaatccct aaactgcgaa 1418161 aaacatgaaa tcgaacctgc aagcccggaa tcgactacat atataacgga tgattatgaa 1418221 cggttggttg aaaatctccc gagtccgcta tgcatcagtg tcaaaggcaa gatcgtctat 1418281 gtaaacagcg cgatgctttc aatgctggga gccaaaagca aggatgctat tattggtaaa 1418341 tcgtcctatg aatttattga agaagaatat catgatatcg tgaaaaacag gattatacga 1418401 atgcaaaaag gaatggaagt cggaatgatt gaacagacgt ggaaaaggct tgatggcaca 1418461 cctgttcatt tagaagtgaa agcatccccg accgtctaca aaaaccagca ggctgagctg 1418521 ctgctgctga tcgatatctc ttcaaggaaa aaattccaaa ccatcctgca aaaaagccgt 1418581 gaacgatatc agctgctgat tcaaaattcc attgatacca ttgcggtgat tcacaatgga 1418641 aaatgggtat ttatgaatga atcgggaatt tccctgtttg aagcggctac atatgaggat 1418701 ttaattggca aaaacatata cgatcagctg catccttgcg atcacgagga tgtaaaagag 1418761 agaatccaaa acattgccga gcaaaaaaca gaatctgaaa ttgtcaagca atcctggttc 1418821 acctttcaga acagggtcat ctatacggag atggtctgca ttccgacgac cttttttggt 1418881 gaagcggccg tccaggtcat tcttcgggac atctcagaga gaaaacaaac agaagaattg 1418941 atgctgaaat cggaaaaatt atcaatcgca gggcagctcg cggcgggaat cgcccatgag 1419001 atccgcaacc ctcttacagc gatcaaagga tttttacagc tgatgaaacc gacaatggaa 1419061 ggcaacgaac attactttga tattgtgttt tctgaactca gccgtatcga attaatactc 1419121 agtgaactgc tcatgctggc gaaacctcag caaaatgctg tcaaagaata tttgaacttg 1419181 aaaaaattaa ttggtgaggt ttcagccctg ttagaaacgc aggcgaattt aaatggcatt 1419241 tttatcagaa caagttatga aaaagacagc atttatataa acggggatca aaaccaatta 1419301 aagcaggtat tcattaattt aatcaaaaat gcagttgaat caatgcctga tgggggaaca 1419361 gtagacatta tcataaccga agatgagcat tctgttcatg ttactgtcaa agacgaaggg 1419421 gaaggtatac ctgaaaaggt actaaaccgg attggagagc catttttaac aacaaaagaa 1419481 aaaggtacgg ggcttggatt aatggtgaca tttaatatca ttgaaaacca tcagggagtt 1419541 atacatgtgg acagccatcc tgaaaaaggc acagcgttta aaatttcatt tccaaaaaaa 1419601 taaaaacaac ggcttaaacg ccgttgttta tcgtctgcat tgcttcacgt ttttttaata 1419661 caaataattc taaacggtct aggccttctc tcagcgtgtc cattgagcat gcaaaagaca 1419721 gccttacata tccttcacca tatgttgaga acgagctgcc cggcacgagt gccacgccag 1419781 cgtcttccaa aagagccata ctaaaatcaa atgaagtcat tccaaatgat ttaatagaag 1419841 ggaagatata aaacgcaccg gacggtttaa ctacgtcaag tcccatggaa acaagacggt 1419901 cataaacata gtccagacgt tttttgtatt gttctctcat aatcaatgca tcgtcaaagc 1419961 cgtttgtgac agcttcaagc gcggcttttt gagaaatgga tgaggcgcac gacacattgt 1420021 attgatgaac ctttaaaatg tgctttgcaa tgtctttcgg tgcaaataaa aatccaattc 1420081 tccaaccggt catgctgtgt gattttgaca acccgttaat gacaatcgtt tgatcccgca 1420141 aataggttgc gatggagtaa tgcggtctgt catatgttaa ttcactgtat atttcatcag 1420201 acaatacgaa gacatttctg ccttttaaga gagctgcgat gcttttcagt tcttcttcag 1420261 ataaagtcac gccggtaggg tttgacggat aaggaagcac gacacacttg gtgttgggtg 1420321 tcagagcatc ttcaatcagc cgggcggtaa gcttaaagcc gtgtgacgta gtatcaacaa 1420381 tgacaggctt ggccccgcac aaattgataa taggttcata gcccggataa ataggccctg 1420441 gcataatgac ttcatcaccg ggagataaaa tcgtccggaa tgcagcatca atggcttggc 1420501 ttgcgcctgt tgtgatgata atttcagatt cagcatcata gttgaaatcc gcttttttct 1420561 tcatataaag ctgcacagct tgtctcagct ccaggtagcc ggcattcgga gtatatgacg 1420621 tcacgttttc atcaatggct ttttttgcgg cagctttcac atgatgcggt gtgaaaaaat 1420681 caggctggcc gattgtaagt gaaatgacgt cttcgtgttg ggctacaaga ttcgagaatt 1420741 tgcgtattcc tgaaatttcg atctctcttg ctttcggatt cagcaaatgt tccataattc 1420801 atcaccttaa caaatataat gagtttatcc tattttacca ctagctgatc atttgtcacc 1420861 tttttaactg atatatttcg attgtatgcg ccttttttct aaacatacct ttcttttcag 1420921 aaaaaaagaa gacaaccagc gatttgattg tctttattgt atcatgttct attattgttt 1420981 atatgtgcca atttcattaa tagccataat caaaatgaag gtcttcgtgc caaatcagat 1421041 acggaggatg ctcttcttga aggtcagctg attctttctt catattcagg taagtttctt 1421101 cactgatatc ctctaaaaca gtcatttcgt tttctttaaa tattactaag gtacccatta 1421161 tttacaccct tctttggaaa aatccttgac tattttatca ctgttagttg gaaagtcaat 1421221 ggttattagg aaaaaagttt cttttttgag gaacgcggct tgttgccttc ggaattcgat 1421281 tttgaagagc tgccattcac tttttacaaa ttacgccgat atatacagta caatactgaa 1421341 tgcgaatagc gagggattga attgtcgtta caacaatacg aaattttatt ggattctggt 1421401 acaaatgaat tagaaattgt gaagtttggc gtgggtgaaa atgctttcgg aattaacgtc 1421461 atgaaggtaa gagaaattat tcagcctgtc gaggtgacat cagtgcctca ctcccatcag 1421521 catgtagaag gaatgattaa actcagagga gaaatcctcc ctgtgatcag tctcttctca 1421581 ttttttggag tagagcctga aggatcaaaa gatgagaaat atatcgtgac tgaatttaat 1421641 aaacggaaaa ttgtttttca tgtcggctct gtttctcaaa ttcacagagt atcctgggaa 1421701 gcgattgaaa agccgacatc gttaaatcaa ggaatggagc ggcaccttac cggtattatt 1421761 aagctcgaag acctgatgat ctttttgcct gactatgaaa aaattattta tgacattgaa 1421821 tcagattcag gtgttgacac gtataatatg cataccgagg gcttcgatga aagaagaact 1421881 gataaaaagc ttatcattgt agaggactca ccgcttttga tgcgcctctt gcaggatgaa 1421941 ttaaaagaag cagggtacaa caatatcgct tcgtttgaaa atggaaaaga ggcatatgaa 1422001 tacattatga accttgctga aaacgaaact gatttatcaa aacagattga tatgatcatc 1422061 actgatattg aaatgccaaa aatggacgga cacaggctca caaagctgct gaaggaaaat 1422121 ccgaaaagct cagatgtgcc ggttatgatt ttctcatcgt taattacgga tgatctgcgt 1422181 caccgcggcg aagttgtagg cgcagatgag caaatcagca agcctgagat cagtgatttg 1422241 attaaaaaag tggatacgta tgttattgaa taaataaaaa cagccgttgc cagaaagagg 1422301 cacggctgtt tttattttaa aagtaactct cgccaagttt tttaaagacc ggtttatggt 1422361 aagctggctg ctggcgattt ggcactagcg gcttttcttt catgccgaca tattcttgca 1422421 ataggtgttt cgcttttgtt aaagacattt gagctttagg atttcgatac gattgattaa 1422481 gtgtacctaa atgcggaaga tgttcgaagt cttctttagt tggaggcatg tgaaaatagt 1422541 agtctccgat tgagataagc acgtccgatt gctgttggct gaaccttgga ttttttgaaa 1422601 aatgaagccc tattttcttt cctttacctt ctttgacaag cttttgcaaa gcccgttttt 1422661 tcagcagata taggtattta gggttggggg cggtttttgc atggcggttc acagtgtaaa 1422721 ctgcttttga aagattttct acggttggct gcagatcttt cgtatatgca tggtcgtcca 1422781 ttatttctct cctttgctct tatcaatttc tatatgttta gattatactt ttttaaagtt 1422841 gaaatgcaaa tattgaatgt aaaaatgcgc ttttttctaa gaaaaaaagc gcatttttaa 1422901 cctgcattat acagatcttg ccttcttttt cggctgttct tgaaatgctt cctgaacatt 1422961 cacttccaca gcctgagcac tgtattttgg cagtgcaata aaataaaaaa taaaaacgag 1423021 caggataata acacccatgc cgtaataaag ataatcaatg tttgaaacaa acttagggaa 1423081 taacagcgcg actaagccga gtgtcaaaga ttgtgcaaac atcataaaag ggtcctgcat 1423141 gccgcttaca cgtcccatca gttttggatg aacaattttt ggcatccacc ctccgattgc 1423201 aatgttgatc ggtccgatac acattcccag tgcaaaagct gccgcgtaat acacccataa 1423261 aatattggtg tagccgagga cgaagatcag caaacctgca atgaaaatcg gtatcgacat 1423321 taaaaagtgc ggcttcactt ttttagagat gagcgtgccg attacgcttc ctgccagaag 1423381 cccaaacccg agtgcgatcg taaatacaga cgtatgccac tcataacggt caggcgccaa 1423441 tccatatttc attgtaaaca tcggcaatac ggcgaatcct ccattgacaa atccaaaaat 1423501 gaagaagcca aaaataagag atgccagcaa tttgtttttt aaaatataga ggatgccttc 1423561 tctaaagtca tttattgaat ccttaacaga agtctttctc cagctgaatg caccgtttgg 1423621 ctgtcgggct tcttttggaa tccggcagct gcggatcagc agcccggaaa tgataaagct 1423681 gacaaaatca agaataatgg cgccttcaat accgattgtg ttgtacataa acgcgcctat 1423741 gccgactcca aacaccataa aaatgctaaa aagcatctga ttaagccctg ccgctttcgc 1423801 ataatgctcc ttcggcagaa tggcttgtac caaactgttt tctgccggaa agaaaaactt 1423861 tgttacagcg cttctgataa ataagataca aaaaacaaga ggaatattgc cggtaaataa 1423921 agtgaaaaaa agcacgacag tcaggcctgc tctgatccaa tcacaatttt ctgccacctt 1423981 ttttctatca aaccggtccg cgacgactcc cacgatcaga aatacaaata tggtcggaag 1424041 agaatacatc agctccgcca aggtcgtata tgaaggctgg ctgctgaatc ggtccagcaa 1424101 aaaaaaagca aaggccatgt tgcctactgt cgtgcccatt tgagaagcga gtgctgcgaa 1424161 aaatagacga acaaaattac gatttttaaa tatatccata aaaacgctcc ttaccctaaa 1424221 ggtcccactt tatcatatta taaaccgcct gtttttgaaa caaataagaa aacattaccg 1424281 gttaatcgtg actctcgttc cgtttggcac aattgaagca agttcgatca cgtctttgtt 1424341 atgcatgcga atgcagcctt tagaaacagc cttaccaatc gaagcgggat tattcgtccc 1424401 atgtattccg tagtgctgct ttgaaaggct cagccaataa gcgccaaatg ggccgccggg 1424461 attgcgctgg cggttaataa tgtaaaactc gccagtaggc gtttgcgtta gtattttacc 1424521 aacggcgatg ggataggttt tcattacccg attatttagg gacagcgtaa gggtcttcgc 1424581 tccgattgag actgcgatat gatacggaat tgtataaggg tccggcagtc cggggatgac 1424641 tatggactgt cccgcggtga gccctgcctg cagtgacgga ttagcctgga gtaatgcagc 1424701 cgtgctgatt ctgaaatcag ccgcgatgct gttcagtgta tcaccttgct tcacctggta 1424761 cgtaagcagt ttcctcatcc tcctttttta cttataagta ttgatgagga gcccatcctg 1424821 ctacattaat ttgtgctttt taaggtgaag acagtgattt caggcttggc aagaaaccgc 1424881 aaaggcagcc tggtcatccc gaggcctcgg tttacgtaaa tatgagtgct gcccgtttga 1424941 tacattccct ctgtgtagac ttttccatat ggaggcgtaa taatcggtcc gtaaaaaggc 1425001 agctgaatct ggccgccgtg tgtatggccg gaaagctgaa ggttcacggg ataatctgtt 1425061 gttttcaagg ctgcatcagg ttcatggacg agaagaatgg aaaaaagtct gtcgctcagc 1425121 cttgaaaggg tgccttcata atctgggttt cccagcatta agtcatcaag cgaagcaatc 1425181 tcgattttgc tgccatctgc gagtgacaat gtttgatagc cattgcgata taccgtgaaa 1425241 cctccggccg tcatcaggct tttgtaaacg gcagttccat agcctccgtg atcatgattg 1425301 ccgtaaatac aaagcttgcc gaagggagca ttaagctttc tcaataatgg aatgactgcc 1425361 tggtggtgct ggtacgtatc aggattatca ataatatcac ctgtaaaaac aatgagatca 1425421 ggtttagatt cattaattgt aagaatgaca gtttttaaat cttcgagagt aaagtaatca 1425481 ctcaagtgtg catcgctgaa ctgcacgatt ttaaaaccgt caaatccgtg cgggatgaga 1425541 gagcttttta ttgtgtgttc ggttgtctcg atcatatgcg gctcgagata cctggcatag 1425601 ccatatcccc cgccggccgt taaagccccg gcagcaagag cgccgaacat tccttttaga 1425661 aattgtcttc tggacatctt tttcatttca aaccaacctt taatagagtt tttctattat 1425721 atcatctgta tctgataaaa atctcatatg agcatgtgct gacagaggca gggatataat 1425781 gatagaatat tattgaatga ataatcattc acaattggag ggataaacat ggaaaaaaag 1425841 gcggtaatta ttaccggcgg gtcaagcggc atgggaaaag cgatggcaaa aaaacaggct 1425901 gaattagggt ggcacgttat ggtgacaggg aggaaccatg aggcacttga ggaaacaaaa 1425961 aaagaaattc agacctttga gggacaggtc gcttgttttc aaatggatgt ccgttccgat 1426021 tccgccgctt cagacatgat taaagaagcg gtaaaagcct ttggccggct tgacgcgctg 1426081 attaacaacg cggccggaaa ctttatttgt ccggcagaaa agctgacgcc caatggatgg 1426141 aaagccgtta ttgagattgt tttaaacggc acattttttt gcagccaagc agcggcaagg 1426201 cattggattg accagaagca gcagggtgtc attttaaata tggcagccac gtacgcttgg 1426261 ggagcgggag cgggggtcgt tcattccgct gcagccaaag cgggggtatt gtcattgaca 1426321 agaacgctgg ccgttgaatg ggggagcaaa tacggcattc gtacaaacgc gatagccccc 1426381 ggaccgattg aacgaacagg cggtgcggag aagctatttg aatcggaaaa agcgatggcc 1426441 cgcacgatga acagtgtgcc gctcggccga ttgggcacac cggaggaaat cgccgctttg 1426501 gcagcgtttt tgctttctga tgaagcatcc tatataaacg gggattgtat cacaatggac 1426561 ggggggcaat ggctgaatcc ttatccgttt taatctgaat atttataagt gaatatttaa 1426621 gttattaaga acttttatgt tcgaatgtaa tacctccaca attaaccttc ttcctatcca 1426681 atttgataac acatagagct ttatttgttt atgaggtgtt gtgtcatacg taagccacct 1426741 aatatatgaa aggtatattt taaaagggga gacgaaatat gaagaactta gatttcaaat 1426801 aaaacattca tataattact tcgttaacta aaaagagaaa ttataagaat gaaaggtttc 1426861 aaggttacat cagattggga ggaaggtaat ataatggacg agatggtatt attaactcag 1426921 gaatggctca atgaaacgta caaaggaaaa agtggctaca attccattga ggaaaatggg 1426981 aaaactggct ggaaaacaat gtatgcatta actagagcat tacaactaga attgggaatt 1427041 acacagactt ccgacagttt tggtcctaca actttaagaa agcttaaaga attaggcccg 1427101 atttctacgt caactaattc aaaaaaaaat attgtgaaaa ttattcaagg tgctctttat 1427161 tgtaaaggtt atggtccagg tggattaacg ggtacatttg gtcagggaac gaaagaggcg 1427221 atagcagaaa tgcaattgca tatggggctt tctaaaacag acggtgtagt aacgcctaag 1427281 gtgtttaaag ctttattaaa catggactct tatatccttt taaatggggc gtcagagaaa 1427341 gttcgttcaa tacagcaatg gctaaataat aaatattaca atagagagaa tttctacttt 1427401 atgccctgtg atggcctgta ttcaagggat actcaaaagt ctcttgttta tgcaatacag 1427461 tacgaggaag ggttaagtga tagtatagct aatgggaatt ttggaccaac tactcaaaga 1427521 ttgattcctg tattaagaat tggagaaaca gatgaaaaaa acagttttat tcatttattt 1427581 caagctgctc taatctttaa tggctacaat gttccttttg atggagtata ctctgaatct 1427641 gtaagatcaa aagtaaaggc ttttcagtct tttgcaaaat tacaacagag tggtactgcc 1427701 gactttcaaa catgggcttc acttctagta agtactggag accccaatcg aaaaggagtt 1427761 gcttgtgact caattactca aattacatcg gacagggcgg agtcccttaa gagggcaggt 1427821 tataagattg tagggcggta tctaacaaat gcgccgggga gtacactaaa taaaaaaata 1427881 caaccaggtg aattagaaac tatcttaaaa tcaggtttaa atgtttttcc gatttatcaa 1427941 acctatgggg gagcaacaaa ttattttaat aaagaacaag gaaagaaaga tgcgtttgct 1428001 gcttataaag cagcaaaaga atacgggttt aaaaataaca ctgtaatata ctttgcagta 1428061 gattatgatg catatggtaa cgatttaaac aacaatatta ttccacactt cgaaggtata 1428121 aatgaaataa tgaacggttt tttaggttca acttacaaaa ttggtattta tgcccctagg 1428181 aatgtatgta ctatagtttc taaaaaaggt ttagcatttg caagttttgt aagtggtatg 1428241 tctactggct ttagcggaaa cttaggatat cctttgcctt acaattgggc gtttgaccaa 1428301 atttcaacaa ttactgttgg aaatggttct ggaatgattg aaattgataa tgatatttgt 1428361 tcaggtttgg ataatggagt taataccata aatatagtgc cttcagagaa taagaagttt 1428421 tttgatcaaa ttgatgtttt atatgaaact gctgaaaaat atgctcaaat gcaaagcgac 1428481 ttaaataatg gggtaaaaaa aacacaatta gctaatgagt tggttgccca gtatttaaga 1428541 aaggatgact acaaagggtg gaagtgggtc cctaccgcag gccagattga tcctatttat 1428601 cgtgaatggg cagtaaagcg ctaggggaag acctagtaaa tggaattgtt gatcctatat 1428661 caaaaactgt cataggaacg cagcatctta tggcaactta taatgccatt atttatagtg 1428721 gtggttactc tcaaacacta cgagattttg ctggttggac tggagatcta ttaacaacaa 1428781 tacaggacat gaaattacac gctcaagaat ttaattcgcc ttatgatgcg gctatgaaaa 1428841 taataggtaa tatgtatcaa tttagcctag atgatttatt tagtgatgta gatgcaatta 1428901 atctagcgaa taaaacatca gttggtgcta atgcacaacc tctaaatatc gcaattagag 1428961 attattatag taataatgac tgtatgaata ggttcactca atttgtaaat aatagatttg 1429021 atggttcgtt agacaaaatt ttctctgaag cagagtatta tttaaataca aaccttgacc 1429081 cagttgttgt tccaattagg ttagccttta aacgtgcttt tgatgttgag gattatagtg 1429141 aagagattgg aaaaataaca gcacaagcat ttagagatgt tatcgagaaa aaaatgatat 1429201 ctgaataaac tgcaaaacaa gcgaacgtta aaactggtcg ttcgcttgtt ttattttcta 1429261 tttaaattta tgatataatt tttaaagatt aaggagtgat tcattgaaga aattgttaaa 1429321 aaagttagtt gtattatttt taagcagttt agttatcatc tttaatgttt ggtactttat 1429381 tatttgtgct ttttccccag agtattatca aaatacaaat cttacttcta atgaaataat 1429441 aagatttgaa aaactatacc acatagattt tcctgatgaa acaaaattta ttaaagctag 1429501 agagtatttg gctgggcccg gaggagatac gtcagctgta ttatatgtgt ctctgccaac 1429561 caagcgggta gaaaaagttt tatctgatta cacgtatatg aaaataaact atactgacaa 1429621 tgtcggttca atgtatggag ttgacgtttc aaagagtgtc gccggtttaa caactcttac 1429681 atttggcact tacgataaaa aaggaacttt ctataatatg aaacatgatg atgattggat 1429741 gtataaaggc actgactgga atctttactt ttggacagct gctagttata atgctgttat 1429801 ttttgtattt gttttggtta ttgtgaaaca aatgaataaa attcttaatt aaccagtatg 1429861 tagattgata atctcaaaaa aattttcctc ttcttttaac atactccata cgacctactt 1429921 ttccatacta tgattttttt gaaatttgtg gtgtagttat aattgtgcgt ataatcagac 1429981 aaagatagag aagcaggtga taacatgttg gatccacttg atattttaac gaacattgat 1430041 gatgtccttc catattacca ggcgattttt agtgccgagg agcagaaggt tgtcggatat 1430101 gaggtgcttg gacgaatttt ggcagattca gaaatccaaa gtctcgggcc cttcttttta 1430161 gatgcgggga tacccgaaga atataaatta gaggttgata acagaattat ccgccaggct 1430221 cttgaccgct ttttagaggc ggattctgat ctgctgattt ttatgaatca ggatgccaat 1430281 ctgctgatgc tggatcatgg tgaaagcttt ctggagcttc tgaaagaata tgaagcgaag 1430341 ggaatcgaac tccaccgttt tgtgcttgaa attacagagc acaattttga aggggatatt 1430401 gagcagctct accatatgct tgcatactat cgtacatacg gaattaaaat cgcagttgac 1430461 aacatcggaa aagaaagcag caacttggac agaatcgcgc tgctctcacc agatctgtta 1430521 aaaatcgatt tgcaggcgct gaaagtgtca cagccgtcac cgtcatatga gcatgtgctg 1430581 tacagcatat ctttattagc aagaaaaatc ggtgcggcgc tgctgtatga agacattgag 1430641 gcgaacttcc agcttcagta cgcctggaga aacggaggcc gctattttca gggctattac 1430701 ttagtgtctc catctgaaac gtttctagag agagatgtat tgaaacaaag acttaaaact 1430761 gaatttcacc aatttatcac acatgagaaa aagaaactgg agaccgtcta tgagcactct 1430821 gaacagtttt acaaacgagt gcatcaggct gtgacctctt tgagaaaaaa caatctgtct 1430881 tctgatgatg actttattaa aaagctggcg gaagagctga cagattgcag cttcaggatt 1430941 tacatgtgtg atgaagaagg cgatcagctg acgggaaatg tgtttaagca agatggagaa 1431001 tggatttatc agccggaata tgcggaaaag aactggagct ggcgccctta ttttctggag 1431061 aacattatga gaatgagaaa tctcagaaaa ggttttttca gtgatctgta cagtgatttg 1431121 gaaacaggtg aaatgatcag aacgttttca tatccgatgg atgatcagat gtatttattt 1431181 atagacttgc cttattctta tttatatgag caggacggac tgatttaacg gctgaaaggc 1431241 cgtttttttt atgaaatgaa aaaaatatca aaaaacgatt gacattgata ctgagaatca 1431301 ttatcattta attatagaga gaagctactc tctgttcccc aacccctcta tcagatcaag 1431361 atccgaaaaa acttggcgct acccccgcca agttttttat ttgtcaaagc ataggacaat 1431421 ccaatgaaac aataaaccta actagtggta aacgtttaac acggggagaa acattgagtg 1431481 ccgaacaccc ctgacactgc tgcacgggtg aggaggaaaa ttcgttctga aatgattatt 1431541 tcagttccgt tgtttacctc tatccagcat gactcccatt gattatggcc acgcgggact 1431601 tcaccataaa attcaaaaga aggttttgac aaagttgcaa aaaggcattc ttaatgctgc 1431661 caaagattcg aaaaaaatta taattatgtg catgacattc aaaaaaagcc tcaaactaaa 1431721 gaaaaatagt ttttttcact ttttttcttt gcttaaattc agcagtgaaa atgccatcct 1431781 gtccgacttt atggtatgat gctcaataga acttgtatta taataaatac ttgttgattt 1431841 gaagttgctt tttgaaagga gtcttttttt agaatgtcac aattaatggg tatcatcaca 1431901 cggctgcaaa gtctgcaaga aacagcggaa gcggctaacg agccaatgca gcgttatttc 1431961 gaagtgaatg gtgagaaaat atgcagtgtt aaatatttcg aaaaaaatca aacgtttgaa 1432021 ctgacggttt tccaaaaggg tgaaaaacct aacacatatc cgtttgataa tatcgacatg 1432081 gtttccatcg aaatctttga acttcttcag taagattcct gaaatagggg gaacaagctt 1432141 ccgcctttgc aaaagtaatc gaaataaacg gtaaggaaca tacttgtttc atggttgtaa 1432201 atccttgaaa aggagtgtcg tgatggctga ttcttttctg ttttataatc tttcagaagc 1432261 acagatgacc tttcaagatg tgatggaacg gcttaaagcc tttgttcaaa aggacccccg 1432321 ttcttcttat gtgttatcga tcggaaccga ttcacaggtt taccgcgatt acacaaagtt 1432381 tattaccgca ttgcatttgc atcgtacagg caagggagct tggggctgct tgaaaaatca 1432441 tacagtcgac agacccatac atagccttcg ggagaagatt tcgttagaaa cggcgtacag 1432501 ccaagaaacg gccgctcata ttcttgatgg acacttaatg gatattaccg atctgctcct 1432561 gccctttacc ggtgaggggg cggatcttac ctttgaagtt cacttggata ttgggaaaaa 1432621 agggcttaca aaagatctga tccaagaaat gactggacgt attacctcca tggggattga 1432681 ggccaaaata aagccggatt catacactgc cttcagctat gcaaatcgtt tcacaaaata 1432741 atttggctga aaaagccaag gtaaatgtcg aattatgcgg ttgacgtttg ttatctgatt 1432801 acttattcta gcggtagagc tgaaagtaag ttgtcttgct ttcagaggta ttcagtataa 1432861 aacagggggc ctgattgcga atgagtctta tcggtgaacg atttacagaa gaagaacaaa 1432921 aacttctgct gaatatcctg atcaaccatg agtatgccat cgagctatta agcagtgaga 1432981 tcaacgatat agagacaggg accaaaaacg ttgacggaac cacctacaaa aaacttgtaa 1433041 cgctatacga ccgatttcga tttgaaaatt aatgggacac cctataattg atactccaca 1433101 aagagtatct tttttattga aaggaaactt ttcgacaaat actgataaag tttatattat 1433161 tgcaatatag ggaatgtatt gatgatgaaa atgaaaaggg gtcgaaaaca tgataagctt 1433221 acaatcagat caacttcttg aggcaacagt cggacaattt atgattgagg cggacaaagt 1433281 agcgcacgtg caagtcggaa ataaccttga gcatgcatta ttagtattga caaaaaccgg 1433341 atacacagcc atcccggttc tggatccttc ctaccgttta catggcttaa tcgggacaaa 1433401 tatgatcatg aacagtattt ttggacttga gcgaattgag tttgaaaagc ttgaccaaat 1433461 cactgttgag gaagtcatgc tgaccgacat tccgcgcctt catatcaatg atccgattat 1433521 gaagggattc ggcatggtca ttaataacgg atttgtctgt gttgaaaatg acgagcaggt 1433581 atttgaaggg atttttacga gaagagtcgt tttaaaggaa ttgaataagc atatacgctc 1433641 attgaataag taggctgtac ggtcctattt ttattatata ggcagagtga aaaaagaaag 1433701 cgcatacata atttaaacga gaatagggct tgaataagaa actaagattt tattagaatg 1433761 ggagataaga aaaacttatt gataacaaaa aggaggacga catgcagctt caagagcttc 1433821 atatgctcgt agttttagct gaggaattaa atatgagaaa ggcggcagaa cggctttttg 1433881 tatctcagcc ggctttatct cagcgcttac aaaccattga aaaggcgtgg ggaacaaaaa 1433941 tctttttaag atctcaaaaa ggattaacgg taacgcccgc cggtgagaaa atcattcagt 1434001 ttgcgaatga tgtgacatta gagcaggaaa gaataagaga aaatattgac gagcttgaag 1434061 gtgaaattca cggcacattg aagcttgccg tcgcctccat aatcggtcag cattggctcc 1434121 ctaaagtcct gaagacgtat gtggaaaagt atccgaatgc aaagatctcg ctcataaccg 1434181 ggtggagcag cgaaatgctg aaaagcttgt atgaggatca ggttcatatc ggcattataa 1434241 gaggcaaccc tgagtggaag gggcgcaaag attacttaat gacagatcat ctgtatttag 1434301 tggatactga aatttcctgc atcgaagata ttgcccatac agaacgtccg tttatccagt 1434361 ttaaaagtga cagcacttat tttcaggaaa ttcagcactg gtggcatcaa aaatttaaaa 1434421 cgtcgccgaa acagacgata ttggttgatc agattgaaac gtgcaaacag atggcgctgc 1434481 acggaatcgg ttatgccatt ttgccgtctg ttacccttca aaatgaagat aaagtgaata 1434541 aaatgcctct tttagacatg aaagggcatc cgatcggtcg ggatacatgg ttattaggtt 1434601 atgagcctgc ctttgaactg aaacaagttc aagcttttgt acaagtgata aaggatatgc 1434661 tggatcagga aaatccattt taaagacagc gaggtgctgt ctttttttta tttatctgtt 1434721 gacaatgaaa atcattatca tttaaagtga tacatatgat attgaaaatc attatcaact 1434781 aatggggtga taacatggct aaagccttga ttacatatgc cagcatgtca ggaaatacag 1434841 aagacattgc cttcataata aaagatacgc ttcaggaata tgagttggat atcgattgtg 1434901 tcgagataaa tgatatggat gcgtcttgtt taacctccta tgattatgta ctgattggca 1434961 cctatacatg gggggacggc gatttgccct acgaagcgga ggattttttc gaagaggtca 1435021 aacagattca gcttaatggt ttaaaaacag cctgcttcgg gtctggcgat tattcttatc 1435081 caaagttttg cgaagcggtg aatttgttca atgtcatgct gcaagaggcg ggagctgctg 1435141 tttaccagga aacactaaaa attgaattag cgcctgaaac agatgaagat gtggaaagct 1435201 gccgagcgtt tgcgagaggt tttcttgcat gggcagatta tatgaacaag gaaaaaatcc 1435261 atgtttcata aaggggcaac cgctgttacg gcatcggcgt tttctggata ttttgtggcg 1435321 gtacaaagag aaggcatttt tcattactct ttggagcagg gctggagaaa gctttttcgt 1435381 ttgaaaagta agatacactg tatcagctac atagggcctt acttatttgg cgttggtgaa 1435441 aagggaacag tcattcgttc ggctgatgaa gggaaaacct ggacgatgtc gagctttccg 1435501 acaaatgcaa cagtgtgggc gattaccggc agaaacaacg ggtttgtctg cgcccacggt 1435561 aagcattgta tttatgtatc ggatgatttt ggtgtctcat ggcgcgtagc caaacctttt 1435621 gccgaatttc ataatccccc tgttatccgg tcgttatgcc ttcacggggg caatctcttt 1435681 atcggcacgc aaatacacga atattttggc ggcatttggg cttacgacat taagcgtgac 1435741 actgtccaag ttgtcaaaaa agaaaaaaac cggatgacgg catccatgct cgtgttcaat 1435801 gaaaattggc tggtggcggc gatgggttct gtgaaaggaa agcacggtgc tgtcactgta 1435861 aggaatcttt tgaatggtga agaattcacc atacaatcca gtatgatcag aaatgaagaa 1435921 tcatttcttg atctttcaga ggatgatggc attatatatg tcactacaac acaagatgaa 1435981 aatggttttt cgagaattta ccaggttgat ctcgaagccc ggtcgttaaa atggttcgat 1436041 accattaagg gacatggatg gagagtggcc aatcagaaag agaatttctt ttgcgcaggc 1436101 ttgtatgaat gtaaatttgt ccagccgtac gaagtttcag caatgattca ttagaggagg 1436161 aacaaggaat tggcgaagat tttgctcgtt tatgcaacaa tgtcaggcaa cactgaagct 1436221 atggcagatt tgattgaaaa ggggcttcag gaggcgttag cagaagtaga ccgtttcgaa 1436281 gcaatggata ttgatgatgc ccagctgttt accgattatg accatgtcat aatgggaacc 1436341 tacacgtggg gagacggaga tctgcctgat gaatttttag atcttgttga agacatggag 1436401 gagattgatt tttccggcaa aacatgcgct gtattcggtt ccggtgatac agcatatgaa 1436461 tttttctgcg gagcggttga tacgctagag gcaaaaataa aagaacgcgg tggagacatt 1436521 gtgctgcctt cggtaaaaat cgaaaataat ccagaaggtg aagaagagga agaattaata 1436581 aacttcggga gacaattcgc aaagaaaagc gggtgcgctg tctgatcact cactgggaac 1436641 tgctaaaacg gctgttcctt tttttcttgt ctttgtatct ttcctttgat acagtaatga 1436701 ggtagaaaat caggaggagg actatacata tgaaaatgat ggacgcaaat gaaattattt 1436761 catttattca aaatagtaca aaatctacac ctgtaaaggt ttacgtgaaa ggtgagctgg 1436821 aaggaatcaa tttcggtgaa tctgcgaaag cttttatcaa tggaaacact ggtgtcgttt 1436881 tcggtgaatg gagcgaaatc caaacagcaa tcgaagaaaa ccaaagcaaa atcgaagact 1436941 atgtggttga aaatgaccgc cgcaattctg cgatcccaat gcttgatctt aaaaacatca 1437001 aagcgcgtat cgagccgggt gcgatcatcc gcgaccaagt tgaaatcggt gataacgcag 1437061 tcatcatgat gggtgcttct attaatatcg gttcagtcat cggcgaaggc acaatgattg 1437121 atatgaacgt tgtgcttggc ggacgagcta ctgttggaaa aaactgccat atcggcgcgg 1437181 gttctgtact tgcgggcgtt attgagccgc catccgctaa accggttgtg attgaagacg 1437241 acgtcgtaat cggcgcaaat gctgttgtgc ttgaaggtgt aacagtaggt aaaggagctg 1437301 ttgttgctgc gggagcgatc gtggtaaacg acgttgagcc atacactgtc gttgcaggca 1437361 caccagctaa aaaaatcaaa gacattgatg aaaaaacaaa aggcaaaact gaaatcaagc 1437421 aggaattacg ccagctgtaa ggaaaagttt gataaaaaag gcgtggataa tatatccacg 1437481 ccttattcgt ataggcagga ggaatagaaa tgaagataga ggagctcatc gcaattcgca 1437541 gagatctgca tcgtataccg gagcttggat ttcaggagtt caaaacccag cagtatttat 1437601 taaatgtctt ggaacaatat ccgcaagaca gaattgaaat tgagaaatgg cgaacagggc 1437661 tttttgtaaa agtgaacggg acggcgccgg aaaaaatgct ggcatacaga gcggatatcg 1437721 atgcgctttc tatagaagag caaactggtc ttccattcgc atcagagcat cacggcaaca 1437781 tgcacgcctg cggtcacgat ttgcatatga caattgcact cggcattatt gatcattttg 1437841 ttcaccaccc agtcaaacat gatttgcttt ttctgtttca gccggcagag gaagggcctg 1437901 gcggtgcgga accaatgctt gagagcgatg tattaaaaaa atggcagcct gatttcatca 1437961 ctgcccttca tattgctcca gagcttccgg taggcaccat tgcgacaaaa agcggccttc 1438021 tatttgcgaa tacatcagag ctagtcatcg atctggaagg caaaggggga catgcggcat 1438081 atccgcattt ggctgaggat atggttgtag cagcaagtac acttgtcacc cagctgcaaa 1438141 cgattatctc tagaaacaca gatccgctag acagtgctgt tattacagtt ggtaccatta 1438201 ccggaggctc ggcacaaaat atcattgcag aaacggccca cctggaaggc acgatccgca 1438261 cgctttctga agaatcgatg aaacaagtaa aggaacggat tgaagatgta gtgaaaggaa 1438321 tcgaaatcgg attccgctgc aaaggaaaag tgacatatcc gtctgtatat caccaagttt 1438381 acaatacgag cggattaaca gaagaattta tgtcttttgt tgctgaacat caactggcga 1438441 cagtaattga agcaaaagaa gcaatgactg gagaggattt tggctatatg ctgaaaaaat 1438501 atcccggatt catgttctgg ctcggcgctg attctgaaca tgggcttcat catgctaagc 1438561 tgaatcccga tgaaaatgcg atagaaacag cggttcatgt catgacaggt tatttttctg 1438621 tttatgccaa ttaagtacaa atgaaagaat aaaattccat aaaatgagca ctctagtaaa 1438681 cggaggtgtt caaaaatggc taaaaaaatt ggaattgaac aatcgttatc agatgtagaa 1438741 gctgctttaa aagaaaaagg atatgacgtt gtaatgatga aaagccctgc tgatgctcaa 1438801 ggctgtgact gctgtgtcgt aacaggtctt gataataatg tgcaagggat agccgatacg 1438861 gtaacacaag cacctgtcat tacagcttcc gggatgacgg ctgaagaaat ttgtagcgaa 1438921 gttgagagca gaattcagta ataaaaaaac cgaagcaaaa agcttcggtt cttttattta 1438981 ttctgtttct ttagggaaag cgcggtcgaa cgcgttcttt atttcttttc tcaacactcg 1439041 ttcgactcgc cactgttcca tattttctgt tttggcaatg accctgatta caatttcaga 1439101 agtccccagt tcttgaatcc cgatgacatt tgggccttct tttatttgtg gaagagccgc 1439161 tgccgtttca tcacaaacct gctgtaaaat atgaatcatt tcatcaatat ttctttcagc 1439221 cggcacttta atgtcaacaa gagcctgcat ggtaccacga gaatgattgc tcacgtttgt 1439281 gatgtttctg ttggggatgt aatgcagtgt tccgtcaaag ctgcggattt gagttgtcct 1439341 taagccaacc tgctcgacaa ttccgtcaaa ggtggaaacg gtaatataat ctccgacatc 1439401 caattgtttc tcaagcaaaa taaaaaaacc tgtcacgata tcactgacaa gcccttgggc 1439461 gccaaatccg acagccaggc cgacgattcc tgcccccgct aaaagagcgc ttggatcata 1439521 atgaaacaaa tctagaacca tgacgaaaaa tatgaaaatc aatgtataag caaatatgtt 1439581 aagagtcagg cttcggagcg tatgtgcacg tccgatagac aagctattct gctcctcgaa 1439641 ttttgcaaac agatgtttaa tgattttcat gcctaatgat cgaacgataa aatagagcaa 1439701 tatcataatg gcgagtttaa tgagcagaac accggcattt gtaatcagtc ccgcccaatc 1439761 atattgttta ataaagtcca tgttgagctc cttttctaat tgattgctgc acattgagac 1439821 tagttaccct gtacatgacc atgttaaacg ttttattcaa aaatgtcgaa gccaaagaca 1439881 tacatgattt gttaaaaatt gactcaggaa atctgctttt atataatggc attgcaatat 1439941 aactaaaaat ggttaatcac cctttatttt catgcgattt tgacctttaa gccaaacaat 1440001 aaattggagg gatacatatg gcagaacgta tggtaggtaa acaagctcct cgttttgaaa 1440061 tggaagcagt ccttgcaagc aaagaattcg gcaaagtaag tcttgaggaa aacatgaaaa 1440121 acgacaaatg gacagtgctg ttcttctatc caatggactt cacttttgtt tgtccgacag 1440181 aaattacagc aatgtctgac cgctatgacg agttcgaaga tcttgatgca gaagtcatcg 1440241 gggtttcaac tgataccatc catactcatt tagcttggat caatacagac cgcaaagaaa 1440301 acggtcttgg ccagctgaaa tacccgcttg ctgctgatac aaaccatgag gtatcccggg 1440361 aatatggcgt tttaatcgaa gaagaaggtg tggctttgcg cggattgttt attattaatc 1440421 ctgaagggga gcttcaatat caaactgttt tccataacaa cattgggcgt gatgttgatg 1440481 aaacgcttcg tgttctccag gcgctgcaaa ctggcggact ctgtccggct aactggaaac 1440541 caggccaaaa aacactttaa ttctttccaa gaacgaaaag cggtctagca tattcgttag 1440601 gcctctcttt taaaatagga gggaaaaagc aatgaaatta cgtcagccca tgccggaatt 1440661 gacgggagaa aaagcttggt taaatggtga agtgacgaga gagcaattga ttggggaaaa 1440721 gccgacgctt attcatttct ggtccatcag ctgccacttg tgcaaagaag cgatgccgca 1440781 agtgaatgaa tttcgtgata aatatcaaga tcagctgaat gttgtagctg tacacatgcc 1440841 ccgttccgaa gatgatcttg accctggtaa aattaaagaa acagctgctg aacacgatat 1440901 cactcagccg atttttgttg acagtgacca tgctttaacc gatgcatttg aaaatgaata 1440961 tgtacctgca tattatgtgt ttgataaaac aggacagctc cgtcacttcc aagccggcgg 1441021 gagcggtatg aaaatgcttg aaaaacgtgt gaaccgcgtt ctggctgaaa cggaataggt 1441081 atctgactaa atagtatttc ctaaaaacct gacctcatca ggttttttat ttgtgcaaaa 1441141 agcaatggaa gaagagtaag aagcttattt ttccaaattt gggtatagga attgatgatt 1441201 tgtttgattg atacgctaaa aaacacagct aatttttgat gtttttcctc aattttagat 1441261 aaatctcata tctcataact cgaaaattgt agatattaca ctaaatttct ttaaagaagt 1441321 aagtaaaata tatattttca acattatacc aaataaacta gaaagcccct taatcccttg 1441381 agaataaagg actcttttga aaaataaaac attttcagaa aataaggaat ttttcataga 1441441 gtaaatataa tagtaaaatg ctaaaataat agttgataaa attacttttg taatctaata 1441501 tcttaattaa agatgttaat tttgataggg ggtacattga ggaatgttta atgaaagaga 1441561 agctttgcgc ttgcggttag aacaattaaa tgaagctgaa gtgaaagtca ttcgtgaata 1441621 tcaaattgaa cgtgataaaa tatacgcaaa attaagagag ctggacagaa atggaagccc 1441681 ttccgaaatc aaaaaggatt tccgttctga aaaaaaacct gactctctgc cggttctcgc 1441741 tgagcttgcg gctcaggaaa tcagaagcta tcagccgcaa tcacagcagc agtctgttca 1441801 gcctcagctt caatctattt cctctcttcc tgccggtata ccagacggaa caacacgaag 1441861 aagaagagga acggcaagac cgggatcaaa agcagctaag ctgcgtgaag ctgctattaa 1441921 aacattaaaa cgccacaacg cggcgattaa gagctcggag cttcaaaaag agattgaaaa 1441981 agaaagcggt cttgaaatcc ctaatatgac aacgtttatg caaagcttaa ttaaaatgta 1442041 cccggaagtg aaaaagccat atcgcgggca gtacatttta gagggtgaaa tcgaatctgc 1442101 agaatcagca aacgaataaa tataaagaaa aactgcttgg catcgctcaa gcagtttttt 1442161 tattgaggtt ttttctgtga aggtttgttt tctttttcaa gattaagctt atacacccac 1442221 ttttgataag gcttttcttc agcggctctg tttttcagct cttcgattgt atggctcttg 1442281 gcctggtctg atgattgggc gtgggcaagc tgtttttgaa gcacatgtat ctgtttggtg 1442341 acatcttcaa ggatagtctc tacatgattt ggctgcgcgt aggccgctgg agcttcttct 1442401 tccgtttttt ctttttgttt cgtgccgcca tcaatatcgg caaaatgaga agcaatccag 1442461 gcatcgcttt catcaagttg ccgtttatac gatataatag tttcgtgaaa taatttttct 1442521 ttcgtttttt ctatgtctag cagtctttct ttcgtttcta tgattcgatc tttcatatga 1442581 tcaacttcta ttttaatatg ttttagctga tattcttttt ctaccatttg ctcttttaga 1442641 cgcccgtttt cggcttttat caattcggct tgctgttttg cctgaagcag tgcattttgt 1442701 tcctgctcaa ttgaggcttg aagttcgctg atccgtttat gaagattttt attttcttct 1442761 tcgattttga ctttcgcaat atgaagttta tgtttttctt cgatttcggc tctgcgttta 1442821 taggtttcag cagatagaag ctcctgcaaa acaacgattt tatcaagcag ttcagctctt 1442881 atttggtgca gggtttggct ggtgtgggag gcatgttttt cttttgttga catatgtgtt 1442941 aattcggcag acagctgctg gagtttttct ttcatatcgg tattttcttt gagcagtttg 1443001 ttatttttct gatgaaagta gcttgcttca agttcagaaa tcagcttatg gcaccttgaa 1443061 agctcggatt ttaaataaag gttctcctga gacacgtcgt ggaaaaaagg acctgatctt 1443121 ttcattcgaa ccatctccct catgatgtta acactacaat atgcaaatac tgaacagcta 1443181 ttcctcttta ataaacagac aagcagtagc gttgagcctt tgcttttgct atgcttttaa 1443241 cgaaactaga ggtgagatga tatgaagcat gtaaacgtac tgctggcagg gggagcctca 1443301 cgtcgctttg gagaaccgaa ggcgtttgtc aaatggaagg gcaggatgct ttacgaatgc 1443361 gctaaagagg cacttggaga acaaacggtt atcatcagcc gtcccgaatt tattgataga 1443421 tttcaagaaa acggtgaaaa tgaagtgtat caagatgctg agccatttca aggcatgggg 1443481 ccattggctg gtatatatac cgcttttaaa aagacagacg gtgatcttta tactgttctt 1443541 tcctgtgaca caccgctgat acaaagaagg acgatgctgg agctcaaacg tctgatgatt 1443601 gccggtgcgg acgcggtagt cccaatttca gacggacaag tgcagccatt gattgcgatt 1443661 taccacaaac gtatcatgcc agttctatac gatcagcttt ctgagaagag gttgagaata 1443721 tcagatttat taggcagaat ttcggtttgt tacgtacagg ctgaaaatat cggagcaaac 1443781 ccggcagagt ttatcaacat taatacacgt gatgatttta gctgtttgga agaaaaatcg 1443841 aactccctca agcgggactg acggggcaat aacatgataa gatgacataa aagataagga 1443901 gaacaggttt gatggaggaa cgttattcac ggcaaatcag atttaagcaa attggggaag 1443961 agggccagaa aagactggca gacagccatg tgctgattgt cggagcggga gcgctcggca 1444021 ctgcaggagc tgaagggctt tcgagagcgg gagtcggtac gattaccatt attgaccgtg 1444081 actatgtgga gtggagcaat cttcaaaggc agcagcttta tacagaaagc gatgccaaac 1444141 tccgcatgcc gaaagccatg gctgccaaag agcatctatc agcgattaac agcgagatac 1444201 atattgaggc gtatgttacc gaaggaacag ccgaaacgct tgagccgctg attgaaaaag 1444261 cagatgtcgt gatcgacgcg acagataatt ttgaaacccg catgctgata aacgatcttg 1444321 cccagaaaac aaagacacct tgggtctatg gcgcctgtgt aagcagccag ggaatgttca 1444381 tgactgtcat tcccggagaa accccttgtc tgtcttgttt gtttgagcaa attcctgtcg 1444441 gcggggcgac gtgtgatact gccggcatta ttccgcctgc tgtgcatatc gtttcagcat 1444501 atcagcaggc tgaggcatta aagctgttaa ccggccaaaa agaagcaata cagcgggggt 1444561 ttgtgacatt tgatgtctgg aacaattcgc atatgaagat taacgttaat catgtacgcc 1444621 gtgaggaatg cccatcttgc ggagctaatg cggtatatcc ttatcttcag gattggaaca 1444681 caccaaaagc tgctgtacta tgcggccgtg atacagtgca ggtaaggtca gaatcattaa 1444741 aaagaatccc gaaacaggag ctcattaagc ggctgaaaac aatcggcaag gtcgaggcta 1444801 atgcgttttt gctgcatatt ttttacgagg atttcagaat tgtcattttc aatgacggac 1444861 gggcactggt gcatggaaca aatgatgtga aagaagccaa ctccgtgttg gcaagagtga 1444921 ttggactgta acaacaggag gggtcagaat gctggagaaa agaacaccga taccggtaga 1444981 cgaggcagtt cggcgtgtct gccattttca aaaacaaggt gaaacagaat gggtggcgct 1445041 tgaagacagc cttcatcggt ttttagccga agatataact gcggatcacc acgtacctgc 1445101 gtttgaccgt tcgccatacg atggttttgc tgtcagagcg tgcgatacgg cagaagcttc 1445161 acgtgaaaac ccagttcggt ttgaagttat tgaccatatt ggagcgggag cagtatctga 1445221 aaaagaactt ggcccgtttc aggccgtgcg gattatgact ggcgcgcaaa tccctgaagg 1445281 ggcagatgca gtcgtcatga ttgaactgac tcaagccttt gaggagaatg ggaagtcatt 1445341 tatgtcttta aaacgccgct ttcagacggg ggataatatt tcaaaaacag gtgaggacgc 1445401 tcaaaaaggg agtgttttac tgacaaaggg cacccgggtg acaccaggag tgacggctct 1445461 tttggcaaca ttcggatacg catctgtgcc tgtcgtgaga aagcctgtag tcgggattat 1445521 cgcaaccggt accgaattgc tgaatgtcag tgatccgctg gaaccgggaa aaatccgcaa 1445581 cagcaatgcg agtatggtat atgcgcaagc gatagaagca ggcgcaacac cgctttattt 1445641 agggaaaatc tctgatgaac tggataaaag ctttgctgca gttaaagaag cgatgaaaaa 1445701 ggtggacttc ctgatcacaa ctggcggtgt gtcagtcggt gactttgact ttttgcctgc 1445761 gatctatgaa aaactcggag cggacgtgct gtttaataaa gttgccatgc gcccgggcag 1445821 cgtgacaacg gtggcgcatg caaacgatat gctgctgttt ggcctttcag gtaatccgtc 1445881 ggcatgctat gtcggttttg aactgtttgt caaaccgata atccagacat ggctgctcaa 1445941 tgaaacaccg cattcaattt gtgcggaagc tgttttgacc aaggattttc cgaagccgaa 1446001 cccatttacc cgatttgttc gtgcgctcgt gcaccatcag gaagggaagc tgttggcgac 1446061 acccgttggc ttagataagt cgagctctgt cacatcactt gcagatgcca atgcatttat 1446121 tatcctgccg ggcggtacgc gaggctacga atctggcaga acggttcaag tgctgctcat 1446181 cagagaagag aatggaagtg aatggccttg gtccgtcctt tcccgatcgt ccaagttgta 1446241 ggatttcaaa acagcgggaa aacaacgttt attgagcgca ttcttgaaaa agcctctgaa 1446301 cagggagtcc atttgggctg cctgaagcac catggtcacg gcggtgaacc gcaaacgctc 1446361 acggaaggaa aagacacgga ccgttacaag gcggcaggtg ctgatgtaac agcggtagaa 1446421 ggtgctggtg tgttacagct gactgcccgc cgcaattggg atttggcacg gctgattgag 1446481 ttataccaat ttctcgaaac agactgtctt ctgattgaag gctttaaaaa agccccttat 1446541 cctaaagtgg ttatcctaag tgaaaaggaa gatctggaag cgctgcaagc agtaaatata 1446601 atcgccatca tctatagaaa aaaagagcat atgacagagc atcagggatt acccgttttt 1446661 catgcggatg atccggttgc cgtggatttt gtgctttcac agctgaaggg ggaatctgca 1446721 taatggaacg gtttgagatt acgaaaacac ccattaatac tgaaaacatc atcaaaaaag 1446781 tggagaaacg ggaagcggga gccattacaa catttattgg tacggttcgg gaatggacaa 1446841 acggaaaaag aacggttcgg cttgaatatg aggcatatga accgatggcc gtgcaaatgc 1446901 ttgctcaaat cggcgctgaa atcgaagaaa aatgggaagg tgcctcagct gcgatcacgc 1446961 accgtatagg tgtgctcgat atcggtgaag cagcggtagt gattgctgta tcttctcccc 1447021 atcgaaaagc cgcatatgaa gccaatgagt atgcgattga acgcattaaa cagattgtgc 1447081 cgatttggaa aaaagaaatt tgggaagacg gtgagcaatg gatcggcgac cagctagaaa 1447141 cgacagctta tccgaacgga aaaccagacc taagcgaggg agagcagcat gattaaaatt 1447201 cttttatttg cagggcttgc tgaacaggcc ggtacacaag caatagaaat agatatggaa 1447261 caagcaacca cagatgaaat aaaagcgagt ctaaaagaac aatacggtct tgaatctatt 1447321 gatacggcta tgattgccgt taacgaaagc tatgtaaaag aaaatacctc tgtatcttcg 1447381 ggtgacacgg tagccatcat accgccggtc agcgggggat gaaaaccgga cggcatttca 1447441 gccgtccggt ttttctgtat ttcattggca tatccccaag tatcctcagc atacaatgat 1447501 tttctgtaag cgtttattct acatatgtta ctccctataa agtaagagac tcactccata 1447561 attagactga aattttgaaa aataatagaa atttatttcg ggtatcgata tagtgaagat 1447621 gataaatgtt ggaaaggtgc tggatatgga gacatttaaa agattaaaaa tgtattattg 1447681 gccgtacaga aaagtgttta tgtggtcgct tctagccatg cttttgatga ctgcaattac 1447741 tgtcgtttat ccgattatcc tgcaaattac gattgatgag atcgtactgg gacggcagta 1447801 tcagcttgcg gcgtgggtca gcttaggatt tattgcggtg atggttttga aaggaatggc 1447861 tacctttttt catcagtatt taggtgatat gttcgggatc aaatccgttt atcggctgag 1447921 aaatggtctg tatgaaaaac tgcagcggct ttctttttct tactatgata acgcgaaaac 1447981 aggagatttg atgtccaggc tgactgctga tgttgaaggg cttcgttttt tcttatcata 1448041 cggtctcgct gagctcattc gcttcggcct gctggtagcc atcagcctgt cggttatgtt 1448101 ttactattct gttcctctca cgcttgtgac aatagctgtt ctgccatttc tcgcggttgc 1448161 ggtataccgg tttgacaaaa gagtccatcc cgccttcaga ggcatccgca aatcgtttgc 1448221 gaaactcaat acaaaagttc aggaaaatat cagcggcatt aatacggtta aatctctttc 1448281 cagggaagat tttcagatca gcactttcaa taaagccaat gcagaataca gggcgcagta 1448341 tttacaaaca tcatccattt ggtctgcgta tttcccttta atggagttca ttggtaacac 1448401 ttgtattgta gctcttctct catacggcgg ttacttggtt atgcaaaatc agctcaatcc 1448461 cggcgagctt gttgctttct tcagccttgt caattatatg atgtggccca ttatgaactt 1448521 aggttttgtc atcaatatgt tctctcaagc aaaagcgtca ggggaacgcc tgctcgacat 1448581 tctggaaaaa gaagaagaca ttacagatca tcctcatgct ttgcataaac aaaaattaac 1448641 cggagatgtc catttcaaaa atgtttctct tgcatacgga aaagaacaaa caaacgcgct 1448701 gtgcaatgta agctttgagg caaacagcgg gaaggtaatc ggactgttgg gcccgacagg 1448761 ttcaggcaaa agctcagtga cacagcttct caccagattt tacagtcctg ttggcggaat 1448821 gattaccatt gatcacaaac ccatcacaga ttattcgtta aaaacccttc gctccaatat 1448881 cggggtcgta cttcaagaat ccttcctgtt ttcatctacg attagatcaa atatttcgta 1448941 tgggcggccg gatgcctcaa tggaagacgt catcgaagcg gcaaaaaggg cgcaggctca 1449001 taactttatt atggagcttc ctgatgggta tgacaccatg ctgggagaga ggggaatggg 1449061 gctttccggc gggcagaaac agcgtattgc cattgcgaga gccatctgct tgaacccgag 1449121 cattttaata ttggatgatg ccacaagcgc agtagatatg caaacggagc acagcataca 1449181 gcttgcctta aaagaagtca tgaaaaaccg cacaaccttt atcgtcgctc accgcatttc 1449241 ttcactgaaa cacgctgatg aaattctcgt ttttaataaa ggacgcattc gtgaaagggg 1449301 aacacatcat gagcttcttg aaaaaggcgg ctactataaa aagatttacg atttgcaata 1449361 ccgtgatgtc aaaatgatta atgagccgca tgaggtcgga tagggagggg ccaaatgaaa 1449421 caagcgaaaa aacagggggt tttagagcgt ttctattact cttcagatga aatcattgaa 1449481 aagccgttta actgggctca aatgtggcgg ctgctgagct atgtcaaacc atatcgaaaa 1449541 acaattttgc cgctttcttt tctcactgta ttgattggca ctgctgtgaa gcttgtgatc 1449601 cccattttga tcggcgttta tgttcttgat caagcgatta cagggagaaa ctcggagctg 1449661 ctgattcagc tcatttttat tattagcggt ttatatgtcc tcaattacgc cgccaatgtg 1449721 ttaagaatca ggtggatgaa tcagcttggc cagcatgtca tttacgattt gcgacagcat 1449781 ttatttaccc atgtgcagcg cttatcccat cgattttttg atcagcggtc ggcgggatcg 1449841 atcttagtca ggatcatgaa tgatattaac tctcttcagg agctctttac aagcggagtc 1449901 atcaatttgt tgaccgactt gctgcttctg gccggcgtga ttattatttt gtttacgctg 1449961 agccctgagc tgactatagc catcatggtg acattgccga ttatgttttt tatttcaaca 1450021 agtctcagaa aaaaaatacg ccgatcctgg caaacggtac ggctgaagca atcgaagctc 1450081 aactctcatc taaacgaaag cattcagggc atccgggtca cgcaggcatt tacgcaggaa 1450141 gaagaaaaca tggcgtattt tgacggtgtc aatcaggaga actacgaatc atggcgggaa 1450201 gcaactagaa aaaatgccat gttccgtccg cttgtagaaa tgacgaatgc gattgggacg 1450261 gctgtcttga tttggtatgg agccacactc atcatgaatg aaaccattac gattggcgtc 1450321 ttcgtttctt ttgctttcta tctgggaatg ttttgggaac ctatttcgag actgggtcag 1450381 gtctataatc agctgttaat ggggatggca tcatcagaac ggatttttga gtttctggac 1450441 gaacagccaa atgtcaagga gaagccgaat gccattcata atgaaaagat aaatggggag 1450501 atcagttttg aagaggttga attttcgtat gatgaaaaac gaaaagccct tcacgccgtt 1450561 tctttctcta ttcctgcggg atcgacgctt gcgcttgtcg ggcatacagg gagcgggaag 1450621 acgacgattg ccaatttaat cagccgtttt tatgatgcgg ccggaggcac cattaaaata 1450681 gacggtatac cgattaagga tctttccctt gccagtctgc gctctcaaat cagcattgtc 1450741 ctgcaagata catttatttt ctccgggacc atcatggaaa atattcgttt tggaaggcca 1450801 aatgcttcgg atgaagaggt gatgaaagcg tcccaagcgg tcggagcgga tgagtttatt 1450861 tccgatttag cggaaggata cgcaacagag gtagaggaaa ggggcagcgt actgtctgcc 1450921 ggtcagcgcc agctcatttc atttgcaaga gcattgctcg ccgatccggc tattatcatc 1450981 cttgacgaag caacggcaag cattgataca gagacagaag taaaaattca gcaagcgtta 1451041 aaaacgcttc tgaaagggcg tacagcagtg atgatcgctc acagattgtc tacgatccgc 1451101 gacgccgacc gcatcattgt tcttgatcac ggcaggaaaa tagaagaagg gaaccatgat 1451161 cagctgctcg ctaaaggagg catttatgcc gggcttgtga aagcgcaata cagcacagcg 1451221 atagaataat atgaaaagcc ttcaatattg aaggtttttg gaaatttatt agaaaaacat 1451281 gaaacttttt gatatccttc ccgtactatt tgttagatat tctcaaggag gttttgaaat 1451341 ggaaacgaat gtagaaaaaa acagcggaac ggcgactgaa aagccttcac ttttcggagt 1451401 aatcacaagt ccgtccgttc aatttgaaag aataagagaa aggccggctg tatggggacc 1451461 gcttttgatt gttgcagcaa ttatcatcgt cggtgccgtg ctgcaatcac tcggtacgga 1451521 ttatagtgag cttttgaaaa gccaggatac gcaagggcta tctgctgaac aaatggaaac 1451581 tgtcgcaaca ataaccaaat ttggcggaat ggcaggcgct attatcggcg gtatcgcagc 1451641 attatttatt gcccctctta tttattggct ctgtgtaaaa gtatcaggcg gtgttacgac 1451701 atataaaaaa atgctttctc tcagtctgtt tgtctctttg attagcagtc tcggattatt 1451761 ggttaatgga atcgttgctt ttacgactga cgtgaatcct ctttacagca cgacgtcact 1451821 cgcagggatt atcccatctg acggggctct cgccagtgtg ttaaatacct ttgaaatttt 1451881 cagcatctgg agctttgtat tattagcaat cggacttcac aaaacgggag gcatctcaaa 1451941 aaaagccggg tggatttcag caatcattct attcggaatt ttagttgtat tttcgctttt 1452001 ttcaggttta atcaattctg tggcgggtgc ataagctcat gaaaaaagtc tggatcggaa 1452061 ttggaatcgc agttatagtc gctctttttg ttggaatcaa tatataccgg tctgccgctc 1452121 cgacaagcgg cagcgccggc aaggaggtac agacggggag cgttgaagaa aatgaaatct 1452181 catcaacggt tatggttcct ggcacgctaa aattttcaaa tgaacagtat gtcttttatg 1452241 aagcggataa agggacatta gaagacatta aagtaaagga aggcgataaa gttaaaaagg 1452301 gcacggcttt agtcacctat acaaatgagc agctgagcct ggaaaaagaa cagaaccagt 1452361 taacgtctga atccaaccgg cttcaaattg accaaattca agaaaagtta aaagccttgg 1452421 acagcaaaga aagagaactg gaaaaacagg taggaaagaa agaagcagaa aaacaaatcg 1452481 aatctgaacg gacagagctt caaatgcaga aaaaaacagc ggagatcgaa ttaaaacaaa 1452541 ccgagcttca gcggcagtca cttgccaacc gggtgtcaga tttagaagtg aaaagcgaaa 1452601 ttgaaggcac cgttatttct gtcaaccaag aagcggcatc caaaaagtca gatattcaag 1452661 agcctgtcat acatatcggc aacccaaaag accttgtcgt ctcagggaaa ttgtctgaat 1452721 acgatacatt gaaagtcaaa aaaggccaga aggtcacact cacttcagat gtaatacagg 1452781 gtaaaacatg gaaaggcacg gtttccgcag tcgggcttgt tccggatcag caggagagcg 1452841 ctgcggcaca aggaacagaa caggcggtcc aatacccgct tcaagtgaaa ataaaaggaa 1452901 atcttccaga aggaaagcca ggctttaaat ttatcatgaa tattgaaaca gataaacgga 1452961 aagcaaatac gcttccttca aaggcagtca aaaaagaaga tgaccaatat tatgtgtata 1453021 cagtaaaaga cggaaaagca aagcgagttg atgtcaaaat cggcgaagtg acagatgacc 1453081 tgacagaaat taaagagggg cttacccaag atgatcaagt cattttgaat ccatctgatc 1453141 aggtgactga cggaatggaa gtgaaatcct aaatgattca gctttctaat gtgcgaaaaa 1453201 gctaccagat cggaaaggaa acgtttgatg ttctccattc tattgatttg gacattcatc 1453261 aaggtgaata tgtctcgatt atggggccgt caggatcagg aaaatcgacg atcatgaata 1453321 ttatcggctg tcttgatcgg ccgacttccg gtacatatca attggacggc gaagacattt 1453381 cttcatataa agataaagaa ctggcggcag tccgtaaccg gtccatcggt tttgtatttc 1453441 agcaatttca gcttcttccg cggctgaacg caaaaaaaaa tgtcgagctg ccgatgattt 1453501 attccgggat aggcaaaaag gaacgtcaag agcgggctga gagagcattg gaaaaggtcg 1453561 ggttagccga tcgaatgctc cacatgccca acgagctgtc gggcgggcag aagcagcggg 1453621 tggcgattgc gagggcgatc gtgaatgagc cgaaattgat tttagctgat gaaccgaccg 1453681 gcgcgctgga tacgaaaaca agcgaggcga ttatggatca gtttacagca ttaaatgccg 1453741 agggaacgac aatcgttctg gttactcacg agcctgaagt agcagattgc acgaatcgga 1453801 tcgtcatggt gcgtgacgga aacattgttc ctgccagctc cggacaaagg agtgtgggag 1453861 aatgagcctg ttggaaaaca tcagaatggc tctaagctct gtccttgccc ataaaatgcg 1453921 ttcgatctta acgatgctcg gcattatcat tggtgtaggc tctgtcattg ttgtcgttgc 1453981 ggtaggacag ggcggcgagc aaatgctgaa gcagtcgatc agcggcccgg gaaatactgt 1454041 ggagctgtac tatatgccta gcgacgagga gcttgcaagc aacccgaatg ccgcagctga 1454101 atctacgttt acagaaaacg atattaaagg tttaaaagga atagaaggca ttaaacaagt 1454161 cgttgcttcg acttctgaaa gtatgaaagc gcgttatcac gaagaagaaa ccgatgctac 1454221 ggttaacgga ataaatgatg gatacatgaa tgtcaattct ttgaaaatcg aaagcggcag 1454281 aacctttacc gacaatgact ttctcgcggg gaatagagtc ggaatcatct ctcaaaaaat 1454341 ggctaaagag ctgtttgata aaacctcccc tctaggtgaa gttgtctgga ttaacggaca 1454401 gcccgttgaa attatcggcg tgctgaaaaa agtaacaggc ttgctttctt tcgatttaag 1454461 tgaaatgtat gtgccattta atatgatgaa atcctctttt ggcacaagtg atttcagtaa 1454521 cgtatcattg caggtcgaat cagcagacga cataaaatcg gctggaaaag aagcggcaca 1454581 gctggtaaat gacaatcatg gcacagagga ttcgtatcaa gtgatgaaca tggaagagat 1454641 tgcggccgga attggcaaag taactgcaat tatgacgacg attatcggct caattgcagg 1454701 tatttccctt ttggtcggcg gaatcggtgt catgaatatt atgctcgtat cagtcacaga 1454761 acggacgcgg gaaatcggaa tcagaaaatc acttggtgcg acgaggggac agattctgac 1454821 tcagttttta attgaatcag tcgtattgac gctgattggc ggtctggtcg ggattggtat 1454881 tggatacgga ggggccgcgc ttgtttcagc cattgcgggc tggccgtcac tcatatcctg 1454941 gcaggttgta tgcgggggcg tgctgttcag tatgctcatt ggtgttattt tcggcatgct 1455001 tcctgcaaat aaagccgcaa agcttgatcc cattgaagcg ctgcgttatg agtagcctca 1455061 tgcaacatgc atgaggtttt tttatgttta gtgatttcta ctatgaatat aaaagacttt 1455121 tttcattaaa ataagaagaa aatgtcgtac aattgtcctt atttttgtcg aatttacagt 1455181 ttacaaaccc tatagacata cgttaatatg gagaaacgtg aaagattttg atagttattg 1455241 aatgaatttg aatgatttta gttgcctaaa ccgaaaatag cgtttacaat gaaattgtat 1455301 tcaaaatgaa tacgttttca ttaggaggtg aagcatgcta actcctgaac ggcatcaatt 1455361 gattattgat caaatagaaa agcatgatgt ggtaaagatt caagagctta taaatctgac 1455421 taatgcttct gaatcaacaa tcagaagaga tttatcgacc cttgaagaac gcggtttttt 1455481 aaagcgcgtt catggtggag cggccaagct ttccgatatc agacttgaac ccgatatgct 1455541 tgaaaaatca tccaaaaacc ttcacgataa actgaagatt gctgaaaaag ctgcttctct 1455601 tttagaagaa ggggattgca tttaccttga tgcaggcacg acgacattgc acatgattga 1455661 ttttatggat aaaaccaaag atattgtcgt tgtcacaaac ggggtaatgc atatcgatgc 1455721 attaataagg aaagaaattt ctttttatct gcttggagga tacgtaaagc acagaacggg 1455781 cgcgattatt ggaggcgctt cattggttgc catggaccag tacagatttg acaagagttt 1455841 tctggggaca aacggtgtcc atacagaggc tggatttaca acgccggacc ctgatgaggc 1455901 ccttttaaaa cagaaagcga tcaaacaggc aaaacacgct tacgtcttag cagacccttc 1455961 gaagttcgga gaaatttcat tttcggcatt cgccggaata ggcgacgcaa caatcattac 1456021 gactgacgct gaagagctta cattcgataa ttaccaagaa aaaactgtcg taaaggtagt 1456081 gaaaccatga tttacactgt aacacttaat ccatctgtcg attatatagt tcacgttgaa 1456141 gattttactg taggaggcct gaaccgttct tcgtatgata ccaagtatcc agggggcaaa 1456201 ggcatcaacg tatcgagact gctgaaaaga caccatgtgg cgtctaaagc gctcggattc 1456261 gtcggcggat ttaccggaga atatatcaaa acatttttac gggaagaaaa cctggaaaca 1456321 gctttttctg aagtaaaagg ggatacccgt atcaatgtaa agctgaaaac gggtgatgaa 1456381 actgaaatta acgggcaggg accgacaatt tcggatgaag atttcaaagc ctttttagaa 1456441 cagttccaat ctttgcaaga gggagatatc gttgttcttg caggaagcat tccatcttca 1456501 ctccctcacg atacttatga aaaaatcgca gaggcctgca aacagcagaa cgcacgagtt 1456561 gttctggata tctcaggcga ggctcttttg aaagcaacag aaatgaaacc atttttgatg 1456621 aagccaaatc atcatgagct tggagaaatg ttcggcacgg ccattacatc tgttgaggaa 1456681 gccgttcctt atgggaaaaa gcttgtagaa caaggcgctg aacatgtaat cgtatcaatg 1456741 gccggagacg gagcgcttct gtttacgaac gaagctgttt attttgctaa cgtgccaaag 1456801 gggaaattgg taaactcagt cggagcaggg gattccgttg ttgcaggttt ccttgccgga 1456861 atttccaaac agctgccgct tgaagaagca ttccgcttag gagttacttc aggcagtgct 1456921 accgcgttct ctgaagaact tggaacagaa gaatttgtcc agcagcttct tcctgaagtt 1456981 aaggtcacac gtctatagag gaggaaacac aagtgaaaat aactgagctt ttaacgaagc 1457041 atacgataaa gcttaatatt gagagcaaag aaaaagaaaa tgttattgac gaaatggtca 1457101 ctgttcttga taaggctgga aagttaaatg accgacaagc ctataaagaa gccattttaa 1457161 atcgcgaaag ccaaagctcc acgggtatcg gtgaaggaat cgctatcccc catgcgaaaa 1457221 cggcaagcgt tatcaacccg gcgatcgcgt tcggacgttc aaaagacggc gtcgattatg 1457281 aatcattaga cggccagccg gctcacttag tgttcatgat cgcggcgact gaaggcgcaa 1457341 acaacactca ccttgaagca ttgtcaagac tttcaacgct gttaatgcgt gaagaaatcc 1457401 gtaagcagct ccttgaagct gagtctgaag atgccatcat cgacattatt aatcagcacg 1457461 ataaagatga tgacgaagag gaagaggaag aagaagcggc accagcacct gccggaaaag 1457521 ggaaaatttt agcggttact gcatgcccga caggtattgc ccatacattc atggctgcgg 1457581 atgcccttaa agaaaaagcg aaagagcttg gtgtggaaat taaggtcgaa acaaatgggt 1457641 caagcggcat taagcacaag ctcactgccc aagaaatcga agatgcacct gcaatcattg 1457701 tcgcagcgga caagcaggtt gaaatggaac gttttaaagg caagcgcgta cttcaagttc 1457761 ctgtaacggc gggtatcaga cgtccgcaag agcttatcga aaaagcgatg aatcaagatg 1457821 cgccgattta tcaaggcagc ggcggcggtt cagcagcttc aaatgatgat gaagaagcga 1457881 aaggcaagtc tggaagcggt atcggaaaca cgttttataa gcacctgatg agcggtgtca 1457941 gcaacatgct tccgttcgta gtcggcggcg gtattctcgt tgcgatttca ttcttctggg 1458001 gaattcactc tgctgatccg aatgatccta gctacaacac gtttgcagca gcattaaact 1458061 ttatcggcgg cgacaatgca ttaaaactca ttgttgcagt tctggccggt ttcattgcga 1458121 tgagtattgc agatcgtcct ggttttgcgc ctggtatggt cggcggattt atggcaactc 1458181 aagcgaatgc tggattctta ggcggcttaa ttgccggatt ccttgccggt tatgtcgtga 1458241 ttttactgaa aaaagtattt acgtttatcc ctcagtcact tgatggatta aaacctgttt 1458301 tgatttaccc gctgttcggt atttttatca ctggcgtatt aatgcaattt gtcgtcaata 1458361 cacctgtagc ggcatttatg aatttcttaa caaactggct tgaaagcctt ggtactggaa 1458421 accttgtgtt aatgggtatt atcttgggcg gcatgatggc gatcgatatg ggcggtccgc 1458481 ttaataaagc agcctttacg ttcggtatcg ccatgatcga tgcaggcaac tatgcgcctc 1458541 atgcagcaat catggccggc ggtatggttc ctccgcttgg tatcgcactt gcaacaacca 1458601 ttttcagaaa caaattcact cagcgtgacc gtgaagctgg tattacatgc tatttcatgg 1458661 gagctgcttt cgtaacagag ggagcgatcc catttgctgc ggctgatccg cttcgcgtca 1458721 taccagctgc tgtagtcggt gcagctgttg ccggcggatt aactgaattc ttccgagtaa 1458781 cgcttccggc gcctcatgga ggagtattcg tagctttcat tacaaaccat ccgatgcttt 1458841 accttttaag tatcgtgatc ggtgctgtcg tgatggcaat tatcctcggt atcgtcaaaa 1458901 aacctgttac agaaaaataa gaaaaaaagc gtccttggtt cgaaaggacg ctttttctta 1458961 tccggccggc agggagcgcg gttaagttat gtattttatt cttttttatg ataaagtaaa 1459021 agaagagaaa caactgacat agcaattgtc taggaggaaa cactttgacc gaggaaaaaa 1459081 atacgaatac tgagaaaacg gcgaagaaaa aaaccaatac gtacctggaa tggggtaaag 1459141 cgattgtcat cgctgttctg ctggctctcc tgatccgtca ctttttgttt gaaccgtatt 1459201 tagttgaagg ttcatctatg tatcccacat tacatgacgg agaaaggctg tttgtgaata 1459261 aaacagtcaa ctatatcggc gagctgaagc gcggagatat cgttattatc aacggtgaaa 1459321 cttctaaaat ccattatgta aaaagattga tcggaaagcc tggagaaacc gttcaaatga 1459381 aggatgacac gctttatata aacggtaaaa aagtagccga gccttacttg tctaaaaaca 1459441 agaaggaagc agaaaaactt ggtgtcagtc tgacaggaga ctttggaccg gttaaggttc 1459501 cgaaaggcaa atactttgtc atgggagata accggctgaa ttctatggac agccgaaacg 1459561 ggctgggact gatcgcggaa gatcgaattg tcggcacatc gaagtttgtc tttttcccgt 1459621 ttaacgaaat gcgtcaaaca aaataaaaac gccttgctgg cctaggacag caggcgtttt 1459681 tattttgaaa aagaagcgac caatgcaatg cataaaaccg tgatgaacac tgaaccgata 1459741 atagccagca cactgaagaa aaggtgaacc tgtttgttct cttttccgcg cttttctaat 1459801 agccgtttag aaaaaatgtg cgaaaatatg taaataaggg ctatgcctat atataagccg 1459861 atatctttgg cggtaaagcc tgttacggca aggtaaaagc ccgtaaaaaa gatcagtaag 1459921 caatattcag taagtgttaa aagcctcaac gtgttcctcc atgagagtgt gtaattttcc 1459981 aggcggatgc attctctctc tttaattgta acacagctgg ctggtttggg tgtataagtg 1460041 ttttctctct gttttatcag ggaatcattt ctcttgccct gcattcatgg tatactttta 1460101 ttgatgatag acatgatgga ggataataaa tgattgctgt aaataatgta agcttgcggt 1460161 ttgcggatcg caagttattt gaagatgtta atattaaatt taccccaggc aactgctatg 1460221 ggttaattgg tgcaaacggt gccggtaaat caacgtttct aaaggtgctg tcaggcgaaa 1460281 tcgagcctca gacaggcgac gtgcatatga gtcctggcga gcgtcttgcc gtcttgaagc 1460341 agaaccattt tgagtacgaa gagtatgaag tgctgaaagt ggtcattatg ggccacaaac 1460401 gcctgtatga agtcatgcag gagaaagacg ctatttacat gaagcctgat ttctcagatg 1460461 aggatgggat tcgtgctgct gagctagaag gtgaattcgc ggaactgaac ggttgggaag 1460521 cggaaagtga agctgcgatc ctgttaaaag gccttggtat ctcagaagat ctgcacacaa 1460581 aaaagatggc agacctcggc ggttcggaga aggtaaaagt tctcttggca caggcattat 1460641 tcggcaagcc ggatgttctg ctgctcgatg agccgacgaa ccacctggac cttcaggcaa 1460701 ttcagtggct tgaagagttt ctgattaact ttgaaaacac agttattgtc gtatcccatg 1460761 accgtcactt tttaaataaa gtatgtacgc acattgccga ccttgatttt aacaaaattc 1460821 aaatctatgt cggaaactat gatttctggt acgagtcaag ccagctggcg ttaaagcttt 1460881 ctcaagaagc gaacaagaaa aaagaagagc agattaaaca gcttcaagag tttgtcgcta 1460941 gattcagcgc caatgcgtct aaatctaagc aggctacatc aagaaagaaa cttctcgaaa 1461001 aaatcacgct ggatgatatt aaaccgtctt cccgccgcta tccttatgtt aacttcacgc 1461061 cggaacggga aatcggaaat gatgttcttc gcgtggaagg cttaacaaaa acaatcgatg 1461121 gcgtaaaggt gcttgacaat gtcagcttta ttatgaatcg agaagataaa attgctttca 1461181 ctggccgaaa tgaacttgct gttactacgc tgtttaaaat catttccggg gaaatggaag 1461241 ctgacagcgg aacgtttaaa tggggtgtta ccacatctca agcgtatttt ccaaaagaca 1461301 acagcgaata tttcgaaggc agtgatctga accttgtaga ctggcttcgc caatattctc 1461361 cgcacgacca aagtgagagc tttttacgcg gtttcttagg acgcatgctg ttctctggag 1461421 aagaagtcca caaaaaagca aatgtacttt ccgggggaga aaaggtccgc tgtatgctgt 1461481 cgaaagcgat gctttctggc gccaatattt taattttgga tgagccgacc aaccatttag 1461541 acctagagtc cattacagcg ctcaataacg gcttaatcag ctttaaaggc gctatgctgt 1461601 ttacttccca tgaccatcag tttgtgcaga ccattgccaa cagaattata gaaattacac 1461661 ctaacggcat cgtcgataag caaatgagct atgacgagtt ccttgaaaat gctgatgtgc 1461721 agaaaaaatt gactgaacta tacgccgaat aaaaaagcag agatttctct gctttttttg 1461781 atacctaaat gtgaaaggag atcacaacat gaaatttttg gttgtcggag caggtggagt 1461841 aggcgggtat attggcggac ggctttcgga gaaaggaaat gatgtgacat ttctcgtgcg 1461901 ccaaaaacga gctgagcagc ttaaaaaaac cgggcttgtc atccatagtg aaaaagggaa 1461961 tgtatcattt cagcccgaac taatcagtgc cggagaaaca gggcaatttg atgtcgttat 1462021 cattgcttct aaagcatact cgcttggtca agtgatagag gatgtcaaac catttatcca 1462081 tcaagaatct gtcattatcc cttttttaaa tgggtaccgc cactatgagc agctatttgc 1462141 ggcattttca aaagaacagg tgctgggcgg cctgtgtttt atagaaagtg ctttagacaa 1462201 caaaggagaa attcatcata cgagcgcatc gcatcgtttt gtatttggag aatggaacgg 1462261 cgagcgtacg gagcggataa gagcgcttga agaggcattt tcaggtgtga aggctgaagt 1462321 catcattagc gggcatatcg agaaggacat ttggaaaaag tatctcttta ttgcagcgca 1462381 agcggggatc acaacgttat ttcaacgacc gcttggccca atcctcgcca cagaagccgg 1462441 acgtcacacg gcccaaactc ttattgggga aatttgcact gttttacgaa aagaaggtgt 1462501 tccggctgat ccggctcttg aggaagagag ctttcgtacg atgaccagca tgtcttacca 1462561 tatgaagtcc tccatgcttc gggatatgga aaacggccaa acgacagaag gcgaccacct 1462621 gcatggattt ttgattgaaa aagcaaaacg tttatctctc gctgcaccag tattagaaac 1462681 cgtttatgcg aatctgcaaa tgtatgaagc agaaaaataa aaaaaggagg cggaaaagcc 1462741 tccttttatt tacttaaaaa gcccaatttc cgtttctgaa gataggctct cttttcccgt 1462801 ctgccgtaat tccgtcaata ttcatatcct tagaaccgat cataaagtcc acgtgtgtaa 1462861 tgctttcatt taggccttct ttgacaagct cttcacgaga catctgcttt ccgccttcaa 1462921 tattaaaggc ataggcgctt ccgatcgcca aatgatttga cgcgttttca tcaaacagcg 1462981 tgttatagaa aagaatgttt gattgtgata taggcgaatc gtaaggaaca agtgccactt 1463041 cacctaaata gtgagaacct tcatctgttt ccaccagttc ttttaaaata tcctcacctt 1463101 tttcagcttt aatgtcgact atacggccat tttcaaacgt cagggtgaaa ttttcaataa 1463161 tatttccgcc gtagcttaat ggttttgtgc ttgataccac tccgtcaacc ccgtcttttt 1463221 gcggcagcgt gaacacttct tctgtcggca tattggccat aaactcatgg ccactttcat 1463281 tcacgcttcc cgcacctgcc caaacatgct tcctaggcag cttaattgtt agatcagttc 1463341 cttctgcttg ataatgtaag gcagcgtaat gtctctcgtt caaatggtca actttttcat 1463401 gaagattttg gtcatgattg atccacgcct gaaccgggtt gtcttcattt acgcgcgtcg 1463461 ctttaaaaat ttcttcccac agaaggtgga tcgcttcctc ctctgatttg ccaggaaaca 1463521 ccttgtgagc ccagcctgct gatgccgcac ctacgacagt ccagctgact ttgtctgatt 1463581 gaatatattg tctgtatgta tgtaatgctt tgcctgctgc tttttggaat gccgcaatcc 1463641 gtttggaatc tatacctttt agcaagtctg ggttcgacga cacaacagaa atgaaagcag 1463701 ctccattttt ggcaagctct tctctgcctt ttgcttccca ttcaggatat tcttcaaatg 1463761 cttcaaacgg cgcaagttcg tattttaatt tggcgacttc gtcatcctgc caattcacgg 1463821 tgacgttttt tgcgcccttt tcatatgcgt gttttacaat taaacggaca aaatcccgaa 1463881 cgtctgttga agcatttacg actacatact ggcctttttg gacattaacg ccgacttcta 1463941 ccgccagctg tgcatatgta tttaatttct gtgaaaatga atccatgaat cattcctcca 1464001 agcttttttc tcatcatatc aaatatgatc ctataaagga aagaaggagc ccaaagtgaa 1464061 aaacccaaaa cgacacgtct tgggtttttt caatattatg gatgattcag ttttacagtg 1464121 ccgcctgcag gcgaatgggg catatttgcc aaagaaatgc tcatgcctcc aagaataatt 1464181 ccgcttaaaa tggctgcgat cgctactctt cttcctaaat ctcttagcat ctgtttcctc 1464241 cttaacgttt ctccatttcc cacaatatga aggaagtgag gaaaaaagaa gcaagaaatt 1464301 tgccgcgtgt gagaattttg cgggtaaaga ctatttaatt gccttttgca gcttatcaat 1464361 cacttctaaa gaacggcctg tgccgattgc tacagattca agcgggtttt gcgccacgtg 1464421 tacaggcacg acaatctctt ctgtgagcca ttctttaatt ccattaagga gcgcgccgcc 1464481 gcctgttaaa ataacgccgc gatcaacaat atctccgctc aattcaggcg gacagtcctc 1464541 aagtgtcgct ctgatggctt caagaatatg caggagggat tcacgcattg catcttgaat 1464601 ttcgttggat tgaagcataa tggtttttgg aagacctgtc acgaggtcac gtccccgaat 1464661 ttccattgcc tctggtatat gttcaatcag agcatggcca atttccattt ttacctgctc 1464721 agctgtgcgt tcgccgatca gcaaattgta ttttttacgg acgaaagaaa cgatatcctc 1464781 atcaagctgg tctccgccga tcctgataga atggcaggaa acaacgccac cgaaggaaat 1464841 aatagcgacc tctgtcgtcc ctccgccgat atctactacc acattggcaa ccggctcatc 1464901 aaccggtaaa tccgctccga tggcggctgc aactggctct tcgattaaat gaacgttttt 1464961 cgcgccgcaa tttttcaccg catcactgat ggcgcggcgt tctactgctg ttgagcctga 1465021 tggtgtgcaa acgactacgt tcggttttct gaacgacatg ccgatgcttt ttgcggcttt 1465081 tttcataatg tgctttagca ggtcagttgt catatcatag tctgcgatca cgccatcttt 1465141 catcggtctg acagcgacaa tttttcccgg tgttttaccg atcatgtttt tcgcgtcagc 1465201 tccgattgca agcactgctt ttgtcgtcgt atccactgcg acaacagatg gttcatttag 1465261 gataatccct ttatttttgc tgtaaacaag tatattagct gttcctaagt caatcccgat 1465321 ttcagttgat tgaaacatgt tttcacccaa tctctatcct aatttaatat gattctacat 1465381 ttaaagtttc tcagaaatac tgcgattttt gggggtgtgc gtcggtaaag aaatgttttt 1465441 gtaaaaaatc aaggaactgt gtaacagaag taatacattt ttcggtttta tggaaaaaat 1465501 atcttgtaat tcttatagaa agcgggaaac tttttcaaag tttcattcgt ctacgatata 1465561 ttgaggtaca tccttaaaac attacatgag aaaagaaaca tttaaaggaa gaagggtttt 1465621 tatgaaatca ataggtgttg tgagaaaagt agatgaatta ggccgcattg tcatgccgat 1465681 tgagttgaga cgggcattgg atattgccat aaaagacagc attgagtttt ttgttgacgg 1465741 agataaaatt atcttgaaaa agtacaaacc tcatggcgtt tgtttaatga ctggagaaat 1465801 cacttcagaa aataaagaat acggcaacgg taaaattacg ctaagccctg agggtgcaca 1465861 gctgcttctc gaagaaattc aagccgcttt aaaagaataa aattatgcta aaaaaggcgg 1465921 agtgatatca tctccgcctt ttttgcgtgc caatttttga ttaccgccgc ctaagataag 1465981 acatcaagat atttggtaat gaatgatttg ggatacttta catattttac tcaattattt 1466041 gtcgaagaat ggtacaataa gtagagaaac acaagcggca ggtggtcata tgagaaaata 1466101 tcaagctcgt atcatttcca tcattttggc aatgattttt ataatgtttt gggattattt 1466161 attttatttt ataggcaaaa acccgattaa ttggcctgtt gatattgtgt atactgcagt 1466221 cacgctggta agtgtctgga tgttggctta ttatattgat gagaaacagc agctggttaa 1466281 gaaaatgaag gataacgaat ggaagtataa acagctttct gaagaaaaaa accgcatcat 1466341 ggataatttg caggaaatcg tatttcaaac gaatgcaaaa ggtgaaatta catatttaaa 1466401 ccaagcgtgg gcatctataa ccgggttttc aatcagtgaa tgtatgggaa caatgtataa 1466461 cgattacttc ataaaagaaa agcacgtagc cgaccacatt aacacccaaa tccaaaacaa 1466521 agcgtcttct ggcatgttta cggcaaaata cgtgacaaaa aacggcacga ttttttgggg 1466581 agaagttcat tataaacttt actatgaccg ggatgaccaa tttacaggca gcctgggtac 1466641 aatgtcagat atcactgagc ggaaagaggc tgaagatgag ctcattgaga ttaatgaacg 1466701 gctggcgagg gaatcccaga aactatcaat cacaagtgaa cttgccgcag gtattgctca 1466761 tgaggtcaga aaccctttaa catctgtcag cggtttcctc cagattatga aaacacaata 1466821 tccggacaga aaagactatt ttgacatcat cttttcagag attaaaagaa tcgatttagt 1466881 gctcagcgag ctgctgctgc ttgcaaaacc gcaggcaatc acatttaaaa cacaccagct 1466941 taatgagatc ttgaaacaag tcacgacatt gcttgatacc aatgcaattc tgtccaatat 1467001 cgtcatagag aaaaatttca aagagacaga tggctgtatg attaatggag acgaaaatca 1467061 gctgaagcag gtctttatca acatcattaa aaacggaatt gaggcaatgc caaagggcgg 1467121 tgtcgtaacc atttcaactg ctaaaaccgc ctctcatgca gtgataagcg taaaggatga 1467181 aggaaacggc atgccgcagg aaaagctgaa gcagattggc aaaccttttt attcaacaaa 1467241 agaaaagggc actggactgg gacttcccat ttgtttgaga atcctgaagg aacatgacgg 1467301 ggaattgaaa atcgaaagtg aagctggaaa aggcagcgtc tttcaagtgg ttttgccttt 1467361 aaaatcagac agctgagagg agaaaaataa agtgaactcg cttctgtttg tatacgggac 1467421 attaagaaag catgaaaaaa accatcattt gctggcacaa tcggcatgta tcaatgagca 1467481 ggcgagaaca aagggaagtt tgtttgctgc aaaagagggg cccacagttg ttttcaatga 1467541 tgaagatgaa ggctatatat atggcgaagt atatgaagca gatgaattgt gtatacataa 1467601 gctcgatcaa ttttttcaag gatatcataa acaaacggtg tttgtagaaa cggatgtcgg 1467661 gattaaaatt gcgcttattt attttatgaa caaagacggg tgtgccggtt ttacgaaaat 1467721 aagcagcggc gactggaaag aacatcagat gatcagcaaa tcgaaaaatc ccatttatta 1467781 ttttgcctat ggatcatgca tggataatgc ccgctttcaa aaagcgggag tcgatcacta 1467841 ttttcaagat ccagtaggaa gagctgtttt aaaaggatac acaacccgct tcacgctaaa 1467901 aagggaagac ggttcaagag cggacatgtt ggaagacgga ggaacaacag aaggcgtttt 1467961 ataccgtatc ccttattctg ctctctccta tctatataaa agggagggcg tcgaatctct 1468021 tacgtatcgg ccggcatttg tagacgttga agctggcgga aggcactaca aagactgttt 1468081 aacctttctc gtcctccaaa aagaagcgga aattgccccg cctcagcact atcagattga 1468141 aatcgaacgc ggagcggagc tgtatttgtc gcctgagttt actgaaaagc tcaagcggca 1468201 tatgaattcg ctgccaaaag gataacactg taacaaaaga atatgataaa atttgatcaa 1468261 tatcatgtca tataaaggag caccacgatg aaaaaagaat ttgcggtaat tgggctgggc 1468321 cgttttggtg gcagtatttg caaagcatta agcgaagaag gcgtcgaggt tatggcaatg 1468381 gatatcgatg aagataaagt caacgagtat gccaagattg catctcacgc agttatcggt 1468441 gattcgacag acgaatctgt cctgaaaaat ttaggcctgc gaaattttga ccacgttatt 1468501 gtagcaatcg gggaaaatat tcaagcgagt attttaacga cactcattct gaaagaactt 1468561 ggcgtccata cgattacagt taaagcgcag aacgattatc acgaaaaagt gctgtctaaa 1468621 attggtgcgg atcacatcgt ccacccggaa cgcgatatgg caaaacgaat tgcgcataat 1468681 atcgtgtcca acaatgtact tgactatttg gagctgtctg aagagcatag tcttgttgaa 1468741 atcgtagcta acagccgcct ggctggaaat acgcttctcg atttagatat tcgcgcaaaa 1468801 tacggtatta acatcgtagc cataaaaagg ggcaaggaag tcatcgtatc accgcttgca 1468861 accgaagtca tccaccaaga agatatactc attgttattg gatcagttac agacatctcc 1468921 cgtttcgaaa aaagagttct tcatacaaaa tagcagccaa ataagccgtc ctcaaagggc 1468981 ggtttttcat attatcagaa tataacaact ttaatgaact gagcgtcaat ttcttaaaat 1469041 ttcattgact aagcacaggc gttccgatag catattgtac catataataa aaaaaggagg 1469101 ggcctatttg aataaagaag cgctagtcaa taggctgaat gcttcagcca aaagacaaaa 1469161 agctgatatc gtcattaaaa acggaaaaat catggacgta tataatcaag aatggatata 1469221 tgaagatatt gcgattacag atggagttat tgtaggcctc ggtgagtatg aaggcgaaaa 1469281 tatcattgat gcagagggac aaatgattgt tccgggtttt attgatggac atgtacatat 1469341 tgagtcgtca atggttacac cgattgagtt cgctaaagca gtgttgcctc atggcgtgac 1469401 gacggttgtt acagatccgc atgagatcgc gaatgtgtct ggtgaaaaag ggattgagtt 1469461 tatgcttgaa caagctcggc atacaccgct gaatatccat tttatgcttc cttccagtgt 1469521 gcctgccgca agttttgagc gatcaggcgc aattctcaaa gctgccgatc tcaagccttt 1469581 ttatgaagaa gaagaagtat tagggctggc tgaagttatg gattatgtgt cggttcagca 1469641 ggctgaaaaa gacatggttc agaaactgct tgatgcccgt gtggcaggaa aaaggataga 1469701 cggtcattta gctggtttat caacagacct cattaacatt tacagaaccg catttgtctt 1469761 aaacgaccat gaagtaacat cgaaggaaga agcccttgat cgtatcagaa ggggcatgta 1469821 tgtcatgatg cgtgaaggat cagtcgccaa aaacacgctc aatgtgctgc cggcggtgaa 1469881 tgaaaagaac gcacgccggt tctttttctg tacggatgat aagcatgtgg atgatttatt 1469941 gtcagaggga agtgtaaacc atcaggtgaa aatggcgatt caagccggac ttaatccgtt 1470001 tttagcctat cagctaggaa gcctcaatgc agccgaatgc tacggattag atacaaaggg 1470061 agcgattgcc ccgggttttg acgctgattt gctttttgta tctgatctgg aaaatgtcac 1470121 tgtcacaatg acgatggtaa aagggcagac tgttgctgaa gacagcaaag cggtctatca 1470181 ggatcatgct tcaactgcag caccagatca ggcactgctt gattctgtta agcttgctgc 1470241 tcctcttaac aaacaggatt ttcatatgcc aatcgattca gagcagcaga tcaatgtcat 1470301 tcaaatcata ccaaatcagc ttgaaacacg attagtacaa gttccggctc ctgttgcccg 1470361 cgaatttgag cctgacactg agcttgattt gttaaagatt gcagttgtcg agcggcataa 1470421 aggattaaaa gaaaccggac ttggtgttgt gaaaggtttt ggattcaaga gcggagcgat 1470481 tgccacaacc atttcacacg actcccataa tattattgcc gtcggaacga atgatgagga 1470541 tatcgcggcg gcagttaata agctgcagga aattggcgga ggattaacaa ttataaaaaa 1470601 tggggaagag ctccattcag taccgctgcc gattgcaggg ttattatccg accaatctgc 1470661 agagcaagtg aatcaaagct tgctgacgct tcatgataaa ttgtcgttaa tcggtttcac 1470721 aggcggattt aatccatttt tgacattgtc gtttttagcg ttgcctgtca ttcctgatat 1470781 taaaatgacg actacgggat tattcgatgt aaaatcattt caacacatat cactgcaata 1470841 aaaagaggca ctcccttagg gagtgcctct ttttttaaac ctccataatg atcggcagga 1470901 tcattggacg gcgctttgtt ttttcgtaca agaaaggtgc aagcgtgtct gtaatttcgt 1470961 ttttgatttc agaccattga gtcgtttttc gttccattac tttttgtaag tgatttgaaa 1471021 tgagctcttg agcgtcgttg atcaagtcac cagattctct catgtacaca aatcctctgg 1471081 aaatcaaatc aggacccgct gaaatcttga agtcgtccat gtcaatgctg acaacaacga 1471141 tgacaagtcc ttcttcagag agaattctgc gatcacgaag tacgatattg ccaatatcac 1471201 cgataccgct tccgtcaatg tacactgaac cggacgggat ttttcctgca actgaagcct 1471261 catcgccttt aagtgctaat acttcaccat tatccatgat aaagcagttt tcctctggga 1471321 tgccacaatc tgttgcaagt ttgacatgca tcttttgcat tctgtactca ccgtgaatcg 1471381 gcatgaagaa tttaggcttg attaaacgaa gcatcagctt ctgttcttcc tgtccgccgt 1471441 gaccggatgt atggatatcg ttaagagggc cgtgaataac ctcagcaccc gcacgataca 1471501 gctggttgat tgttcgactc acgctgattg tgttgcctgg gataggggat gaagaaaata 1471561 cgactgtatc cccaggattg attgaaattt ggcggtgtgt gccgtttgca attcttgata 1471621 acgccgccat tggttcccct tggcttcctg tacataaaat tgttacttta ttagcaggca 1471681 tacgattgat ttcgttatgc tcaataaacg tatttttagg acagttaata taaccgagtg 1471741 tctgtccaat ttcgatagcc gattccatac tgcgtccaaa tacggcaact tttcttccat 1471801 tttgtacagc agcttcaatt acctgctgca agcggtgaat attcgacgca aatgtggcga 1471861 agataattcg gccgtccacc ttgcggaaaa tgtcatgaat gctttctcct acacggcgct 1471921 cagacatggt aaactccgga ttttcactgt ttgtgctgtc tgaaagaagg cacaaaacgc 1471981 cttctttacc gatttcggcc attttcgtta agtttgccgg ctcgccgact ggagtaaagt 1472041 cgaatttgaa atccccagta tgtacgatgt ttccgggcgg cgtttttaca acaatgccgt 1472101 aggaatccgg aatactgtgt gttgttctga agaatgacac agccgttttg cggaacttta 1472161 caatatcatc ctcgccgata atgttcagtt tcgtctgtct caataatcca tgctcttcaa 1472221 gtttattccg aagtaagccg atcgcgagtt ttccgccgta tacaggaata ttcacttgtc 1472281 tgagcaggta tggaataccg ccgatgtggt cttcgtgccc gtgggtgata aaaagccctt 1472341 taattttatc ttcgtttttg actaaatacg tataatcagg gatgacgtag tcaattccga 1472401 gcagttcgtc ctcgggaaac ttgatccccg catcaatcag tacaatttca tcctggaatt 1472461 gcaccgcgta cgtattttta ccgatttcgc ccaaacctcc gagggcgaaa acagcagtct 1472521 gatcattttt tacaaatttc ataccgctca taactccaat actttaaaat tttcgctctg 1472581 ttgttcatat tctaagaatg caccatcaac aggtgtaata aactcaatat taaatttctt 1472641 ttctttcagc tttgttctga cgtcacgctc agatacgcct tcaatataaa gtgaatctgt 1472701 cttttcccga acaggtactt cgtcagcctt ctcttgataa aataccttat aaatcattcc 1472761 aaatctctcc ttaaatgccg tatgttagac tcgctcattc tattatattc gaaaacggaa 1472821 tataaggaaa gccttgagca aaataaggat ctctcaaaaa gtgaaagatc ccttgtcagg 1472881 caattgcttt cttacggagc attccgttcc attgtcttct gagtttcttt cttaatttac 1472941 gcagcattag ccagtccctc ctttaatgaa aaatttgtcc cagagttctt ttatacaaat 1473001 agtatacgga gattgaggaa gacttttcgt ggttattaat ggaatttaat atgatttttg 1473061 aacgaaattg tttgctgaat gacaatcttt ttgtatgatg agggtgggaa ttgcagacca 1473121 agacgataaa ggggaagttg cgatggattc taaattaatc ttttttgata ttgacggcac 1473181 aatatatgat catgataaga atataccgga aagtacgaga aaaaccgtgg cggagcttca 1473241 gcgccaaggg catcatgtgt ttattgccag cggccggtct ccatttttgg ttaagccgat 1473301 tttggaggag ctgggcatcc actcatttat ttcctacaat ggacagtttg ttgtctttga 1473361 aaatcaagtg atttataaaa atccgctgcc tgaaaatgca atcaggcgat tattaaagca 1473421 ggcggatgaa ggcaagcatc ctgttgtgtt tatggctgag gacacgatga aagcgactgt 1473481 tgcggatcac ccccatgttc tcgagggaat cggcagcctt aaaacagatt atccagagac 1473541 cgatgacctt ttttatgaag gaaaagaaat ttttcagctt cttttatttt gtcaggatga 1473601 agaagaaaaa gcttatgccg cttttcctga gtttgatcta gttcgctggc atgagctatc 1473661 gactgatgtt ctgccgcacg gaggttcgaa ggcagaagga atcaaaaaag tgattgagcg 1473721 tcttccgttt gatatcggcg atacatatgc tttcggcgac ggattaaatg atttgcaaat 1473781 gattgaatac gttgggacag gcgttgctat gggaaatgct gttcccgaac tgaaagaaat 1473841 cgcggacttt gtaacaaaac cggtggacga ggatggaatt gcatacgctg tcaaagaatt 1473901 gggcctttta aaataaagaa acggctggca ttgtgccagc cgttttctct tttagcgctc 1473961 aattgcgatt gcattttcag gttctttgaa aggattttcc ttatcaatat gatcatagaa 1474021 cataacgccg ttcaaatgat cgatctcatg ctgaaacaca atagccggaa atccttttaa 1474081 acgaatatca atattttcgc cttctagtgt tgttcctttt actctgatgc gagcatagcg 1474141 gggaacataa ccgggaatcg cttcatccac agagaggcag ccctcgccgc ttgttaagta 1474201 gcttttttca actgaatggc tgacgatctt aggattaaac agagcatagc tgtataattt 1474261 accggaagca tcttccgcat gaacggcgat cattcgtttt ttgatattaa tttgaggagc 1474321 tgcgagtcct acgccagggc gcagcttgta tttttcggct aattctggat tttggctgtt 1474381 tttaacaaat tcgatcatgt cggccagctg ctgtttttct gcatcagttg gaggcagctc 1474441 aacaggttcg gcagtctctc tgagggctgg atggccgtca cgtacgatgt tttccatagt 1474501 aatcaagaaa cttcactcct aaagcttaat atgtaaatta tatcggattt cttcacaaag 1474561 gtgcaacgaa acgaatgacc agccgtatat ggctggtcaa tttcatgctg tgtggttagc 1474621 aacagcctcc acctaaataa gcagctccga caatgattaa cagaatgaat aaaacaacga 1474681 ttagcgcaaa ggtgcggccg tagccatatc cgcagccacc atatccgtaa ccaccataac 1474741 tgcagcagcc tccgccgtaa ccatatccat acatattaca taacctcctc ttttaattac 1474801 gccagagcct ttataagtag gcatagcgtc taatataacc tatgtaaaaa caaaaaagtt 1474861 gtatggtcat ctgtcctgat ttttcacttt tttgatttaa tttcagtatt gcatttatac 1474921 agcacggcta ttgccaaatg tccccatgga ttctatagta gaaattgtca agattggggg 1474981 atttaacgtg aaagacgcta taaaacggcg gcctggaatc aagatcggag ctttttgtgc 1475041 catggcactg atattaacag gatgcatggg acaggacccg gttgattcac ttcatcattc 1475101 attagaaaaa gccgcggaat cggaaaagcc gtttcaagaa gaacaaaaca cactcaaaga 1475161 attagaggcc aaagaaaatc agctttacga tagtgttatg aagctcaata tggatgatta 1475221 taaaaaaatt gttgctttat ctaataaggc gcttgaaaat gtcagcaagc gcgaagaaca 1475281 cctaaagctt gaaaatgaca gcatgaaaaa atcggaaaca gaatttgagg aagcaaaaac 1475341 gtcagcggaa catattaagg aaaaagacat aaaagaaaag gccgatgccg cagcaaacca 1475401 tatggagaaa agatatacat catatggcac tatgtataaa gagtataaaa aagcgcttga 1475461 gcttaataaa aaactgtata tgcagctgaa agacaaagat ttgacaagag atgatctgga 1475521 tcagcagatc gataaagtca atgcttctta tgaaaagatc cttaaatata gcggagaatt 1475581 taatgaacaa accgaaaaat ataataaagc ccgggaagat ttatatgatg ctgcaggcta 1475641 tcgtgtgaaa aagagctgac tcgatcagct ctttttttga atgaaatgcg attcggattt 1475701 cgttcaaaat tttcatttct attgtagtac agcatagtaa ggtatactag tacagttttg 1475761 ggtgcggttg gcatctgttt ttttgatgaa aatgtaaagc gaatacattt attgaaaatc 1475821 agcgatgaaa acgattgacg gttcttcttt atttggtgta aactaatcca tgttaagcgg 1475881 tgttgtatta gttttttaca acttcgaaat aatacagttc aaagcagagt gtaactatcc 1475941 tacataaaag gttttggcaa actggggatc ggctaaaata taatacgact tactgctgat 1476001 actttagggt accctaagtt tgtatgtata aaaggaatgc acgtctaatg actgtttaaa 1476061 agaaaggaag aggtgactta gtatggctgc aaaaacgaaa aaagctatcg ttgacagtaa 1476121 gaagcaattt gatgccatta aaaagcagtt cgaaacgttc caaattttaa atgaaaaggg 1476181 agaagtcgtg aatgaagcgg cgatgcctga tttaactgat gatcaattaa aagagctaat 1476241 gcgccgcatg gtatttacgc gtgtgcttga ccaacgctct atctcattaa accgtcaagg 1476301 acgtctcgga ttttacgctc ctactgcggg tcaagaagct tctcagattg caacgcattt 1476361 cgcgcttgaa aaagaagact ttgttcttcc tggataccgt gatgtgcctc agttaatttg 1476421 gcacggcctt ccattatatc aagcgtttct tttctctcgc ggacatttca gaggaaacca 1476481 aatgcctgat gatgtgaatg ccctttctcc acaaatcatt atcggtgctc aatacattca 1476541 aactgccggt gttgcgctag gtcttaaaaa acgcggtaag aaagctgtcg caatcactta 1476601 cactggtgac ggcggagctt ctcaagggga cttctacgaa ggaattaact ttgccggagc 1476661 ttataaagca cctgcaatct tcgtggtgca aaacaaccgt tacgcgattt caactcctgt 1476721 tgaaaaacaa tctgcagctg aaacaattgc acaaaaagct gtagctgccg gtattgtcgg 1476781 cgtacaagta gacggaatgg atccgcttgc tgtatacgca gcaactgctg aagcacgcga 1476841 gcgcgcaatc aacggcgaag gtccaacact aattgaaaca cttacattcc gttatggccc 1476901 gcacacaatg gctggtgacg atcctactaa atatcgtaca aaagaaatcg aaaatgagtg 1476961 ggaacaaaaa gatccgcttg tacgtttccg tgcgttcctt gaaaacaaag gcttatggtc 1477021 tgaagaagaa gaagcaaaag tgattgagga tgcgaaagaa gaaattaagc aagcgatcaa 1477081 aaaagctgat gctgaaccga agcaaaaagt aactgattta atgaaaatca tgtacgaaaa 1477141 aatgcctcac aaccttgagg agcaatttga aatttataca cagaaggagt cgaagtaagc 1477201 catggcgcaa atgacaatga ttcaagcaat cacggatgcg ttacgcacag aactgaaaaa 1477261 tgacgaaaat gtcttagttt tcggagaaga cgttggtgta aacggcggcg tattccgtgc 1477321 gacagaagga ttgcaaaaag aattcggtga agaccgtgtg tttgacacgc cacttgctga 1477381 atctggtatc ggcggtcttg cccttggttt aggcttaaac ggcttccgtc cggtaatgga 1477441 aatccaattc ttcggatttg tttatgaagt aatggattca gtttctggcc aaatggctcg 1477501 tatgcgctac cgttctggcg gacgctggac ttcacctgta acaattcgtt ctccattcgg 1477561 cggcggtgtt catactcctg aacttcacgc tgacagcttg gaaggtcttg ttgcacaaca 1477621 gcctggtatc aaagttgtta ttccatcaac tccttacgat gccaaaggac ttttaatttc 1477681 tgcgatcaga gacaatgatc ctgttgtctt cttagagcat atgaagcttt accgttcttt 1477741 ccgtcaggaa gttcctgaag aagaatacac aattgagctt ggaaaagctg acgtgaaacg 1477801 tgaaggtact gatctttcaa tcatcactta cggcgcaatg gttcatgaat cattaaaagc 1477861 tgctgatgag cttgaaaaag acggcatttc tgctgaagtt gtcgaccttc gtacagtaag 1477921 cccacttgat atcgatacaa ttatcgcctc tgtagaaaaa acaggacgcg cgattgtcgt 1477981 tcaagaggca caaaaacaag ccggtattgc tgcaaacgta gtagcagaaa ttaatgaccg 1478041 tgcgatcctg agcttggaag cacctgtact tcgcgttgca gcgccagata cagtatttcc 1478101 tttctctcaa gcggagagcg tatggcttcc aaaccataaa gacgttcttg aaacagcaag 1478161 aaaagtgctt gaattttaat caaactgcat aatcgagagg gaagatgaac gttttccctc 1478221 tattatatat ctgttttcaa tgcttacgat gtaaacttta aaattgctta atcaaactag 1478281 gaggtcgaga actgtggcat ttgaatttaa acttccagat atcggggaag gtatccacga 1478341 aggcgaaatc gtaaaatggt ttgtcaagcc taacgacgag gtagacgaag atgatgtact 1478401 ggctgaagtc caaaatgata aagcagtagt agaaattcct tcacctgtta aaggaaaagt 1478461 attagaatta aaagttgaag agggaacggt tgcaactgtt ggacaaacga ttattacgtt 1478521 tgatgcacct ggttacgaag atcttcaatt taaaggcagc gacgagtctg acgatgcgaa 1478581 aactgaagca caagttcagt caactgcaga agctggacaa gacgttgcga aagaagagca 1478641 agctcaagag cctgcaaaag ctactggcgc aggacagcag gatcaagctg aagttgaccc 1478701 gaacaaacgc gtgatcgcta tgccttccgt acgtaaatat gcacgtgaaa aaggtgtaga 1478761 catccgtaag gttactggtt caggcaacaa cggacgtgtt gtaaaagaag atatcgacag 1478821 ctttgtaaac ggaggagcgc aagaagctgc accgcaagaa acagctgcac cacaagaaac 1478881 agctgctaaa ccggctgctg caccagctcc agagggcgaa ttcccagaaa cacgcgaaaa 1478941 aatgagcggt atccgtaaag caattgcaaa agcgatggtt aactctaaac acactgctcc 1479001 tcacgtaacg ttaatggacg aagtggacgt aacaaacctt gttgcacatc gtaaacagtt 1479061 caaacaggtt gctgctgatc aaggaatcaa gctgacttac ttgccttacg ttgtaaaagc 1479121 tcttacatct gcactgaaaa aattccctgt tttaaacacg tcaattgacg ataaaacaga 1479181 tgaagtcatc caaaaacatt acttcaacat cggtatcgct gctgacactg aaaaaggctt 1479241 gcttgtaccg gttgtgaaaa atgcagatcg taaatctgtc tttgaaattt ctgatgaaat 1479301 caatggcctt gcaacaaaag ctcgtgaagg caagcttgct ccagctgaaa tgaaaggcgc 1479361 atcttgcaca attacaaaca tcggttctgc cggcggacaa tggttcactc cggttatcaa 1479421 ccatccagaa gttgcgattc ttggtatcgg acgcattgca gaaaaagcga ttgttcgtga 1479481 tggcgaaatc gtagcagctc cagtcttagc tctttctctc agcttcgacc accgtatgat 1479541 cgacggagca actgcgcaaa atgcattaaa tcacatcaag cgtttactga acgatccaca 1479601 attaatttta atggaggcgt aatgttatgg tagtaggaga tttccctatt gaaacagata 1479661 ctcttgtaat tggtgcggga cctggcggct atgtagctgc catccgcgct gcacagcttg 1479721 gacaaaaagt aacagtcgtt gaaaaagcaa ctcttggagg cgtttgtctg aacgttggat 1479781 gtatcccttc aaaagcgctg atcaatgcag gtcaccgtta tgagaatgca aaacattctg 1479841 atgacatggg aatcactgct gagaatgtaa cagttgattt cacaaaagtt caagaatgga 1479901 aagcttctgt tgtcaacaag cttactggcg gtgtagcagg tcttcttaaa ggcaacaaag 1479961 tagatgttgt aaaaggtgaa gcttactttg tagacagcaa ttcagttcgt gttatggatg 1480021 agaactctgc tcaaacatac acgtttaaaa acgcaatcat tgctactggt tctcgtccta 1480081 tcgaattgcc aaacttcaaa tatagtgagc gtgtcctgaa ttcaactggc gctttggctc 1480141 ttaaagaaat tcctaaaaag ctcgttgtta tcggcggcgg atacatcgga actgaacttg 1480201 gaactgcgta tgctaacttc ggtactgaac ttgttattct tgaaggcgga gatgaaattc 1480261 ttcctggctt cgaaaaacaa atgagttctc tcgttacacg cagactgaag aaaaaaggca 1480321 acgttgaaat ccatacaaac gcgatggcta aaggcgttga agaaagacca gacggcgtaa 1480381 cagttacttt cgaagtaaaa ggcgaagaaa aaactgttga tgctgattac gtattgatta 1480441 cagtaggacg ccgtccaaac actgatgagc ttggtcttga gcaagtcggt atcgaaatga 1480501 cggaccgcgg tatcgtgaaa actgacaaac agtgccgcac aaacgtacct aacatttatg 1480561 caatcggtga tatcatcgaa ggaccgccgc ttgctcataa agcatcttac gaaggtaaaa 1480621 tcgctgcaga agctatcgct ggagagcctg cagaaatcga ttaccttggt attcctgcgg 1480681 ttgttttctc tgagcctgaa cttgcatcag ttggttacac tgaagcacag gcgaaagaag 1480741 aaggtcttga cattgttgct gctaaattcc catttgcagc aaacggccgc gcgctttctc 1480801 ttaacgaaac agacggcttc atgaagctga tcactcgtaa agaggacggt cttgtgatcg 1480861 gtgcgcaaat cgccggagca agtgcttctg atatgatttc tgaattaagc ttagcgattg 1480921 aaggcggcat gactgctgaa gatatcgcaa tgacaattca cgctcaccca acattgggcg 1480981 aaatcacaat ggaagctgct gaagtggcaa tcggaagtcc gattcacatc gtaaaataat 1481041 tttcatatca aaaacagccc cgctttgagc gagggctgtt tttttatttt gacagcacat 1481101 gctgtaatgg tttaatgatg tcttctttct ttttcacaca tccctcgatt ttcaccacga 1481161 catggcgctg atcaacaacc ataagggtag ggacagtttc aatctcatct tcccagcctt 1481221 cttttttatc atagaccttc attttatcta tttgctcggg ataatctttt tctaaatcaa 1481281 gcagtgcatc gtaataaggc gcttcctggt ctatttggtt ctcatcagaa aaaaacagga 1481341 tttgtgtatg atgaatgttg tcaatccggc tttttttcat cggattgatg gtggaaagcg 1481401 tacagcccga taaagcaaat actattatca gcatggggaa taccgcgcga tatcgcatct 1481461 atcttctcct ctgtataaac agtagttaac tagctttagt ttatcacgag agacggctta 1481521 atctgcttct tgttacctaa ttgttatata attgaaaccg tttttaaagt gagattacat 1481581 attatatcaa tcgtttaaaa tagcaacctg gggtatattg aattttttgc tgcattcttg 1481641 gatgaaagtt caagaaaacg tgcaattaca ttatgtgctg tggcatatat atcgagtaaa 1481701 gcttctgtat gaagaagata ttgtatgatg gaaaatggaa aaacaaggtg aatatgatga 1481761 tatgaaataa aatgtgttat acagtttgtt gttgacattt taaatgtgac atattaatat 1481821 aataacaaca aaagaaatta agcgttttca aatttcaaag aaatggggaa taagagatgg 1481881 gtacgattgt ttgccaagat tgcaacgaag ccattcatta ctttgaagat gagaaagtga 1481941 caacattata tggaacttgc tgcggacaat gtcaatgtcc tgttgatgaa gagtaaaaaa 1482001 aagcatgcgg cttaaagccg catgcttttt attttttatt gaattgcttt ttgttctttg 1482061 atgacccgga tcatatgtaa agtcgagtcc tcaggtcctt gaacagggag gcctgcgtca 1482121 aggtttttaa aaatgtagct gatgttttct tctgtaataa tttctcctgg gatgaagatt 1482181 ggaataccag gcggatatac catgacaaat tcagcaataa tccgtccgga tgcttctttt 1482241 aatgggatga cttccgtatt tgcatagaaa gcatcacgcg gagtcattgc caataaaggt 1482301 atttctggaa gcagaacctc agtttgctga tgtgttacat cttgttctga catttgctgt 1482361 gcgatctcag ttaaagcctc tacaagccgg tctgcatcat tttggctgtc accaggagtg 1482421 aaaatacaca aaatattgta cagatcagaa agctccacct caatattaaa ggattcacga 1482481 agccattttt ccacgtcatg tcctgtcagg ccaagacttt tcacagagat aatcaatttt 1482541 gtcggatcat agctgtaagc tgctttcgac ccaagaatct cagaaccgac acaataaatg 1482601 ccttcaatct gattgaggcg atctctcgtc tgattggcaa gcttgagtgt ttcctcagca 1482661 agctggcggc cttctgttgc aaggcgtttt ctggcaacat ccaaagaagc gagaagcaag 1482721 taagaagttg acgtagttgt cagcatgctc aggatggatt gcactctgtc tttagataca 1482781 aggccttctc tcatgtttaa aatagagctt tgtgtcagtg atccgcccag cttgtgtaca 1482841 cttgtcgctg ctatgtccgc tcctgcctgc atagccgata gcggcaattc gtcgtgaaaa 1482901 tgaatgtgaa cgccgtgtgc ttcatccaca agcactggca catcaaacga atgagcgagt 1482961 tctacgatgc tttttaagtc ggctgcaaca ccgaaatatg tcgggttgat gacgagaagc 1483021 ccttttgcat ccggatgctc ggtaagcgcc cgtttagcag attcaagtgt aattccgtgg 1483081 gagatgccca attcattgtc aatttcagga tgaataaaaa ttggaaccgc tccggaaaat 1483141 acaatagctg tcataattga tttatgaaca tttcttggaa taataatttt atcaccaggt 1483201 ccgcaaacag ccattaccat tgtcataatg gcgccgcttg ttccttgaac agaaaaaaat 1483261 gtatgatccg ctccaaatgc ttcagcagcc agatcttgtg cttgtttaat aatgcctttt 1483321 ggcgcgtgca gatcgtctaa tggttcaata ttaatcaaat ctatgcttaa cgcgttttca 1483381 ccgataaatt gtctgaattc tgggtccatt cctgcccctt ttttatggcc gggaatgtgg 1483441 aattgaacag gctgtctgct tgcatgcttt ttcagtcctg tgtataaggg tgtttcatgt 1483501 tgcgacaatt gttttcccac ctttgtaatc atacctatgc ataatagtgt gtattaaaat 1483561 cagtttctca accgtttttt agacgtaaaa caaatgaatt atattatgaa cttgaaagaa 1483621 tgtaaagaac aatttatgat caaatgaaga tgctttctct taagggaagt aaatctacaa 1483681 ggagtgaaga aaatggagta tcaatatccg atgaatgaag attggacaac cgaagaagca 1483741 gtggatgtga ttgcattttt ccagcaggtt gagcttgcat atgaaaaagg ggcggatcgt 1483801 gaagaactgc ttaaagctta ccgccgtttc aaggaaattg taccggggaa ggccgaagaa 1483861 aaaaagctat gcggcgagtt tgaggaacaa agtacatatt ctccttatcg cacggtcaaa 1483921 caggcgagag aatctgatca cgcgaagatt aagatgtaag aaaaagagcc gggggatatc 1483981 ccggctcttt tttatgcttg tgttactttt tgggtgagac ggtacagaaa agcaagctgt 1484041 ttaaaggcat cgtcgatacg ctgaaggaat tcctggttat tcatattcag cacttcttct 1484101 ttttggagct ggatgccgca taacagctcg gctttcttta cagtctgcaa acgctcaaac 1484161 agtgtcttca gctgttcctt gtccatttca gactgtttat gtactcccgg ttttgtgtga 1484221 tctgcagacc aaacgaagct gtcagggata tttttcgtaa tggtttcttg gttcacttca 1484281 agcaatttgc cgtattcttc tttgataggg gattcataaa taatcgcgaa ccatacaaag 1484341 acgtggcttt cccataaacc aatttggaaa tgcggcagtt ttttatagcc tcttttgctg 1484401 tttgcgaacg ccacccagct gtcagccggg ggattgacgg atcttcttgc gtgctttgcc 1484461 acatgcggaa acatttcatc tccggttaaa gctgataaag ttggggcaaa atgttcgcct 1484521 agagctgtaa gcttcggacg gaccgtctct tttaatactt ccatgcgcgc gtctaagcct 1484581 tctattgtaa atgtgttaaa gtcttcttca gtgaaacgca tttgtgtcat gattttcctc 1484641 cttcatgcta agtatacata ttttatcaca gttcatacga gcttcaaaaa gattgagcgc 1484701 gtttgaagta aggagaaatg tggtaataaa cgagtaggta aacacacaat tttcagaatc 1484761 atgttgcgcg taaatagaac aatcatacga tataagaagt aatcattgtt gaatggcaaa 1484821 atgggatgct tttttacaaa caaatgatct ctggaagggg cgaaagacaa tgaggcaagt 1484881 tgtaaaagag ggatttaagg aagagaaaaa caatcgtgtt gctgtctgga gactagaggt 1484941 tgattatgaa ttggcaaccc tatatgaagc aatgcagaaa gaaaatgaag agcagattga 1485001 acaaagcaaa aacaaacttg agcgacttag aaaagaatgg attcgtctta acgggtaaaa 1485061 aagcgatagt gaaaacgaac cgcatgaatg gttcgttttt acgtgagaag ggatattttt 1485121 cattttcctt gctttttcat tgccgttatc agtatcctat aaaataaaag gtctacatag 1485181 aagagaggta cgaacgaatg acaaattgga cggaaatcga tgagattgca aagaaatgga 1485241 taagagaagc aggcgcgaga attacacaat ccatgcatga aagcctgaca attgaaacga 1485301 aatcaaatcc gaatgattta gtcaccaata ttgacaaaga aaccgaaaag tttttcattg 1485361 atcgaattca agaaacattt ccgggacatc ggatactcgg tgaagagggg caaggagaca 1485421 aaatccactc acttgaggga gtcgtatgga ttattgatcc gattgatggg acgatgaatt 1485481 ttgtgcacca gcaaagaaat tttgcgattt ccattgggat ttttgaaaac ggtgaaggta 1485541 aaatcggttt aatttatgat gtggtgcacg atgagttgta tcacgcattt agcggcagag 1485601 gagcttatat gaatgaaacg aagctggctc cattaaaaga aaccgtcatt gaagaagcga 1485661 ttcttgccat taatgcaaca tgggtaacgg aaaacagaag aattgatcaa agtgtgttag 1485721 cgccacttgt gaaaagagtc agaggcacac gctcctacgg ttctgccgct ttagagctgg 1485781 caaatgtcgc ggcaggaaga atagatgctt acatcacgat gcggcttgcg ccatgggact 1485841 acgcagccgg ctgtgtgctg ttaaatgaag taggaggcac ctatacgacc attgaaggag 1485901 agccgtttac ctttttagaa aaccacagtg tgctagccgg aaacccatct atacataaaa 1485961 cgatatttga agagtatctt catgctcgga agtaggccat ttgagcagga tgatctcagc 1486021 ttgttagaaa agctcgcgga ggctcatcct gtatggaaag aggaggagtt tggagataaa 1486081 gatgcagaag actatatcat ttcctactcc atgtacaacg gttcatggct tgtatgggaa 1486141 aaagacggta tgcctgttgc cgtcagctac catctcgagt ggtctccttc aaacggtaag 1486201 ccgtggctcg gaacggtcct gattgacccg gctgaagaaa aaaagggaca tgcgaagatg 1486261 atcattgaac agatcagcaa attgcttaga gcgaaacata aagcgatgtt tgcgggagtt 1486321 cccattgagc gcagggaatg gatactgttt ttaagccaat gcggctttga acagctgaaa 1486381 acggaaaaag atgagaaagg caaatcattt atgatcttgg tgaagccttt agcagaagct 1486441 gccgtatgat aatggcagct tatttgctgc atgcgggttc aataaaaagc ctctcaaaca 1486501 ttgagaggct tctgatgatt tgaaaattat ttttttaccg catgaatata atgaatcgtt 1486561 tcaaacgctg acaaattgtc ttttcgatta ctaaagaaaa ggtcattgat gtcgtctggt 1486621 gatagatgtt catagatcag taaaccagat gactctaaca gatgttcaat ctcttgataa 1486681 gtgaaacatg atttcatcgg ttccccgctt gcggcagcca tcttcaccat atgttcaact 1486741 cgattcgacg tcccttttgc tgtaaaaagt gtttcgtccg cataatcaaa aacaatagag 1486801 cttccaggcg ggacatgaga aaataaattg ctgatcaagc ttgcattttc ttcccgtgtt 1486861 acataataag acactccgag aaggctgaag aatgtttttg tgtttttaaa tccttcatct 1486921 aagagaggat catacgaaaa cgttttggtg aaatccatag gaacaaaatg aagatgaccc 1486981 ggaattgtca gatttgcatc cttcagctta ttttttttca attgctgtgt ggccggatga 1487041 tcaacctcga aaacctgtaa gctgttttct aattctggat gccgaaagca gaaagtatcc 1487101 agtcccgctc caagaatgac atactgtttt gcccccagga ttaattcgtt gtgcaagact 1487161 ttttcacaat aagaagcacg tgctaggggc gttggagaca gctggatttg tgcaacccat 1487221 tttaatattt tttcaggatc attttgaaga cgttcggcga tctctttgtt gaaaaacgat 1487281 atttcttgaa tcatattttt actgatgtcg ataaactctt tttcgttaat gagatctttt 1487341 gcgataaaat catcaaaaat aagaggtgtg tcatatcggc tgtgatatgc acgggcaaaa 1487401 gctgaaatta gagacgttaa gctggactca tttttcctca tgaaatgatc ctccacaaaa 1487461 aataagattc ccctggccag gagaatctta ttatacatac aaatatatta atagtaaatt 1487521 ttagcataaa taaatttttt tgtcaatgtt tttgctctta actggacgcg cgatccttca 1487581 catagccacg tgacctgtag cagaattcgt ctatcaatta tgtggactga atcattagct 1487641 tttataaaat gcgcacttgc ggctgcatcc ctctttatgc aaatcaggag cggttttctg 1487701 tctcatggca gcatcttttc gtcgtttcag ctgagagaga aatcaagata tgtaacaata 1487761 aaagcctgag ggatctcagg cttttcctaa tattacaatc caacagcatt ccaggctgct 1487821 tcaactttag cggcatcagt tgagccgtag aggtcacggg cagactgaat gagagctgcc 1487881 ttggcatctt tgaacgtgga agaaggcgtg aggtacgttg ttaacgcacg gtaatagatt 1487941 tgctgtgatt tagatacacc aagttttgtg atggtgttgt aagcggcttt gtttggaatt 1488001 ccgctgtttg tgtgtacacc gccataatcg ccttcatctg tgtttggaag gtttcggtaa 1488061 ttggcgtaat tgtcaggctg gttgtatttt gtagggttgg acaggctgcg aagagcaggc 1488121 tggctgaccg taatgtcttc accgatgtcc cagtcttctg tatcgttaaa atacccgaat 1488181 acgtcagaga aagactcgtt taatgcacct ggctgatttt cataaatcaa gttggctgtt 1488241 tcttgggtga cgccatgtgt catttcatgc gctgtcacat ctaatgagcc ggaaagcgga 1488301 gagaagaatg aaccgtcgcc atcaccgtaa atcatctggt ctcctgtcca tgcagcgtta 1488361 ttgtattgag tgccgtagtg aacggaagaa acgattttac tgcctttgtt atcatagctg 1488421 tttcgtttaa agtttgaata aaaataatcg tacactttac cgaggttata gtgtgcgtca 1488481 acggctgccc gctgtgatga agatgtaaat gttttcgttg tgcttgagac aagcgtgccc 1488541 ggaaggcggc tttgtctgtt ttgcaaatca tatgtgatga tttgggtgcc tgttggtttt 1488601 gaaagatctc ttagaacata ttttccgcct tcataagaga tgttcaaagg aacagttgcg 1488661 ccctttagcg ttgttccgct tccagtggcg gcggcatgtt ctactttatt ttgctgtttt 1488721 aaaatgctgc ctgtttcggc gtcaactaag acttcccagt ttgcaggttc aggctcgaca 1488781 tagcgaatcg tcacgtcgta agcaagacga tagctgccgt cttttgtttc tatcgctttt 1488841 aattcggctt tattgctgtt tttggccgct ccgttagaaa cagcgtctgg tgatttgccg 1488901 atagctttga aagcgagtgc cagcgctttt tcagaagaga ctttttggct gttatctgtt 1488961 tttgcagcag attgattgtg taattcacca ttgaccgcat agacattatc ggatttatcg 1489021 acgtgaacga tcacttgcga atctttaatt ggcactccgt taacgacagg cgcatatcga 1489081 aagtgcttgt atccaagggc atcagtcgtg ctttcaacaa gcttcagcct tttggaaggg 1489141 tcacctttaa aaatgttgct gttctttttc aaaaactgct tgacagcctt gtcatttggt 1489201 gcagagagtt ctgattgcgc aatcgcgttt ttggagagga aatttgtttg attctcttta 1489261 agctgatgac cttcagcagc ctgaacacct ggcaggctga ttgataaact cataaacgaa 1489321 gcagcgacag caacagacaa tttcttacct aaacccacaa taaatccccc tttttgaaaa 1489381 tactgaaaac tttatattgt tatattaaac tagcattctg gaatactcaa caaaaactaa 1489441 cataactaga caaaattgat agtattgtcc tgtgtttgtt tttgttgaat aatatcaaga 1489501 tgagtcaagt gtcatgtggt ggttcattca agagttatgt tttttacata tcaaggggaa 1489561 gatgagatat ttttgtttca tcttgaaact ttttgaaaag tccgctgtct aaccgaatga 1489621 ggccttaata agaagtaaag gattgttgtt cgtgttggag ttattcagtc attatgtatt 1489681 gcatttcgaa cgttatttta tattaagcag acaaagcacc ctgctgattc aatggtcaat 1489741 tgttgttctg gcgggcttat atcttttggt gcatcatccc aaaataaacc ggcagcgcac 1489801 aatgttcttg gcgggtgtta tattgcggat tgtgctgctg gcgggagtgt ctgttgaact 1489861 tattcaccag gtgcaatcaa caaacttcac cagcgcttac ttaagagagg acggaaaaga 1489921 actgctgccg ctgctgcatt ttttgttata cggatatgtg ctgctgacgg cttttcacta 1489981 tatgctgatg ccgcgtgatc atggcggaaa gggtaagttt tatacgttcg accttgctgt 1490041 tgtcagtttg ccgatcgtac aaatgatttt tagtttcttt tcgtattgga aggaataccc 1490101 ggatgggatg gagccgattg cattcgtgtt tctgtttttc atcatcactc ttcccattgc 1490161 gttgaatgta gtgtttttca agctgtattg gagaacggat aagatcttac taggcttatt 1490221 ttatacgctg attatcggac tgcttgtctt gctgcttgcg ccatatccca atcaaatctc 1490281 aaaagattat ggtgcagtaa tgccatatac gatttatttg gcaatggcgg gatttttgat 1490341 gagctatcat ctgttccaaa agtcaggaaa ggtttatgtg cgtgtgaata agtgggtgac 1490401 gatggctgtc atggtgtttt ttgtcctgct gttaaatccg atatataaca taggaacggc 1490461 tgctttcgct gtatcaaagc cagcaaatgt ccatgattca ttcaattttg tcggggagca 1490521 catttcatca gaaaaagcgg aacagatact aaagtcattt tttcctacgg atgaaacact 1490581 ttatttgcac gatacaaaca tggatgtgca ttatttctac tcatttgaaa gcaaaggtta 1490641 caaagctgag gtagatgaag tatcgcagct aattcgtaat tatgaatact tacaaaaagc 1490701 acatgggaaa aagctaacga atcaggagta caagcgaaag tccatcgctt tccttgagcg 1490761 acacggacgt gtgttacata aggatcatat cgaaacaaag gtatctcaag aagacggcca 1490821 gacagtcgta cgtatttacc tgaaaaatca acttcataaa aaagatcatg ctgatgatgg 1490881 cgcggtattt tattgggaaa aggaaacctt aatggggttt agtgaagatc cttcgattta 1490941 tcagcttgac tctcttctgc atgttcatat aacggaacaa gacattcacg acaaagtgga 1491001 acaaatgttt acagcgctga acatatcaaa acagccttat cagatcactg atattgaaag 1491061 cgacagcctg cttggaagca tggtgagagt tgaaacaaaa gttggaattg ttttggaatt 1491121 tgagggcgaa tcaggttgtt tacatagtct ttcgcttccg atgaaaaaga atatctcaat 1491181 ggctaacagc cggctgcagc atcagatatt atcgatcttc gatgctcgtg gatcagaaaa 1491241 gaagaaaaaa agcagtcagg gtgacatggt gatgtatact gattcttcta aaacatatga 1491301 gtttgttgaa gctcaaggtc agctaaacgt ttatgtatac agcgatacac ctgatcagtc 1491361 attcccctat acgtatcgta atggaacatt ggcttacgaa aaagtagctt ctctatatca 1491421 ggatgtcatt tacaaaaagc gtatgcgtcc gattatcgtt caaagagggg atgaacggca 1491481 ttatgcatgg ctgatcatta ttcagccgtt tggttcaaat cgccatgatg cctatgtagt 1491541 ggatggagaa acacaagagg tgaaaagtct ttatgaatca taaagaaaaa gagtctgttt 1491601 ttgtagactt atacgacctg tataaagaag gagagctaga ggatgaatca atggaatgga 1491661 tgaaacagca tgaatcccta tttcaaaaga atgcggaaga cttaaagagt aaaacttgtt 1491721 taaagagaag tcccggtgct gaagaagaaa gccaaatcag atatatgaaa gtatacctgt 1491781 cttccatgta tatctgtttc attttattgg ccatttggat gacggtgtgg ttttattttt 1491841 aatgaagcat agggattcca ttgaggactt gtatcggcag tattatcaag aaattttaaa 1491901 ttatttattc agaaggactc atcatcttga aacagccaag gacttagcgc aggacacgtt 1491961 tgtaaaagct cttaacggtc tggcttcgtt tagggggcat tcttccatca gaacatggct 1492021 ctacaccatt gcgcatcata cctttatcaa ttggtaccga agggatgtca aataccaatt 1492081 tactgaaatc agcaaaaatg aagggttaac gcaaacaact tatgaccagc ctgaacagta 1492141 tctgtcacgg acggtgaaaa gcgaaacact gcggcaggag ctcctgaagt taaaagatca 1492201 gcatcaatcc gttttgattt taagagaatt ccaagagctt tcttatgaag aaatcgctga 1492261 gatattagga tggagtcttt ctaaggtgaa taccacattg caccgggcta gattagagct 1492321 aaagaaaaac atgacgaaaa gtagagagga ggagcggata tgacctgctt tctagtaaga 1492381 gacctgcttc ctctgtatct tgaaggtgat tgtaaaagag aaacggaaca cgttatagaa 1492441 gagcatttaa aaatgtgcag cagctgcaga gacatgtatg acacgatggc tgagccattt 1492501 gaattggaaa gcgaacaggc cgttgaggag gcttatctgc cggaagaaga actgcgtttt 1492561 aaacagaggt actatggatt actgatcatg aaagctgcct gctggtttgg agcggcggtt 1492621 gccatgatgc tgatcatcaa actgctgata taaaaaaagc gcttgtccga ttccggcaag 1492681 cgctttttta cattaagcct ggggatgaat catatcgtaa atagcggcaa gctgttcttg 1492741 tgacagggca ctgaagagtt tttcataaac gtcagcttgc agtggcgttg cacctgcttg 1492801 tagcgctgcg tctttatcat agctgtacac atcatcttgt agcacaatgg ctgcttgaag 1492861 aatgtgaatc ttgagagaaa cagcggagaa aaattgttca agtgcaagtg cttctttttc 1492921 tgtgaagcca agttcaactg ctttttctgt atcaaatttg taatttccat cctcgagata 1492981 cacacattgt gaaacaatgc tgaaaaattc tgatgtcgat tcccagagtg tagcaattac 1493041 ctgagcctct tcttttgtca ttcctaactc gacagctttt tcgctgtcaa aataatatac 1493101 accgtcttgt tcgtatatac attgatttaa tatatcaatg aatgtattga gatcttcgtt 1493161 agtgctcgcc tgatgctgga gttgaacagc agtgttatca accggtgttt ttgcgctggc 1493221 tgcatcagga ccgaacgtta atagagcagc tgaggtcatt gcggcagtcg ttaacatagc 1493281 tttttttaca aatgttttct tcatgtttct tctctccctt ttatgaattg tgctacaaat 1493341 tccattatag ggagtagttt ccggtggagg aataggcgct atggtatttt atgtgtatcg 1493401 ttgccgaact actttttgaa ggctgcacgt gtgatcgtta gaacgattgt ctatgtatga 1493461 aggctgtttt gcatcttcct gactaagaaa caggggagat aaggcttaaa gaaatgaaaa 1493521 acaccgcttt ctttgcggtg ttttttgatt acaatgtcgc cggcggggca atgcttttaa 1493581 tcaagcaagc cttgttcgcg cattttcttt tttaatgtaa atccgccgcc catgacagcg 1493641 caaacaagta caatgctggc gataatgcct gcagggcttt tttcagcgat aaagacgccg 1493701 atcagcataa tgctgaaaac cgctgcaaat gcaaataata gtaaaagcca attcattttt 1493761 ttcataaatt ccatcccctt ttacgtctta tattaagttt acagaaaaac gtgacgcttt 1493821 taaagaggat gtgtgatata atatgaaagt tatctaattt ttttaggaga tgaaaaagtg 1493881 aaacttcgaa atgatcttcg caacatcgcg attattgccc acgttgacca tgggaaaacg 1493941 actctagtcg atcagctttt acatcaggct ggtacgttcc gtgccaacga acaggttgct 1494001 gaacgcgcaa tggactctaa tgatcttgaa cgcgaacgcg gcattacaat attggcgaaa 1494061 aatactgcga ttaactataa agatacacgt atcaatattt tggacacccc tggacatgca 1494121 gactttgggg gagaagtaga acggattatg aaaatggttg acggcgtagt gcttgtcgtt 1494181 gacgcatatg aaggctgtat gcctcaaact cgttttgttc tgaaaaaagc tcttgagcaa 1494241 aacctgaacc ctgttgttgt tgtaaacaaa attgaccgtg actttgctcg tccagaggaa 1494301 gttatcgatg aagttctgga tctgttcatt gagcttgatg ccaatgaaga gcagctcgag 1494361 ttcccagtgg tatatgcttc cgcgattaat ggaacagcga gtcttgatcc gaaacaacag 1494421 gatgaaaaca tggaagcttt atatgaaacc attattaagc atgttccggc acctgttgat 1494481 aatgcagagg agccgcttca attccaagtt gcccttcttg actacaacga ctatgtaggc 1494541 cgtatcggaa tcggacgcgt attccgcggc acaatgaaag tcggacagca ggtttctctt 1494601 atgaagcttg acggaacggc aaagtcattc cgtgttacaa agatttttgg tttccaaggc 1494661 ttaaagcgtg tggaaattga agaagcaaaa gcgggagacc tcgttgcggt ttccgggatg 1494721 gaagatatca acgttggtga aacggtatgt cctgtagacc atcaagatcc gcttccggtc 1494781 cttcgcattg atgagccgac acttcaaatg acatttgtcg tgaataacag tccgtttgca 1494841 ggccgtgaag gcaaatatgt aacggcccgc aaaatcgaag agcgtcttca atcacagctt 1494901 cagacggatg tgagcttgcg tgttgagcca acagcttctc ctgatgcttg ggttgtttca 1494961 ggacgcggtg agctgcactt gtcaatttta attgaaaata tgcgtcgtga gggctatgag 1495021 cttcaagtgt caaaacctga agttattatc aaagaaatcg acggcgtacg ctgtgagcct 1495081 gttgaacgtg tgcaaattga tgttcctgaa gagcatactg gctctgtaat ggaatcaatg 1495141 ggtgcccgca aaggcgaaat ggttgatatg atcaacaacg gaaacggcca agtccgtctc 1495201 atctttacag ttccttcccg cggattgatc ggttactcta cagaattcct atcattaaca 1495261 cgcggattcg gtattttgaa ccatacgttt gacagctacc agccgatgca ggcaggccaa 1495321 gtcggcggac gccgtcaagg tgtacttgtg tcaatggaaa acggaaaagc aacatcatac 1495381 ggtattcaag gaattgaaga ccgcggtgtc atcttcgttg agccgggtac tgaagtatac 1495441 gaaggaatga tcgttggaga gcataaccgt gacaacgacc ttgttgttaa cgtcagcaaa 1495501 atgaaacagc aaacaaacgt ccgttctgcg acaaaggatc agacaactac aattaaaaaa 1495561 gcgcgcatca tgtctcttga ggagtctcta gagtacttaa acgaagatga atattgtgaa 1495621 gtaacacctg aatccatccg tttaagaaag aagatcctca ataagaacga acgtgaaaaa 1495681 gcagctaaaa agaaaaaaac agcaggattg tcttaatctc gtgcagaatt tgaaaagata 1495741 gaacccgtac gtttacaggg gagggaatct ttttgaatga cgtaagcgaa cgcctgtcgt 1495801 tcttcgccgc tctatatcaa gtagaccggc agcctgcggc aggcatgtgg ctgctgtacg 1495861 gcacgatttt tgtgttggcc gttattgtat ttaagcttgg atttgctaaa cggcttcctg 1495921 tattaaaatc tgcagtggtg tatgtatttt tggctttggg ctgcactgtt ttgacttttt 1495981 taggggtgtt tttgcccgtg gcagaaggat tggtcgtcgc tgcgctgatt ttaatcattt 1496041 acaaaatccg gctgtatcag tcgaaaaaag gacagtctgc aaaatcataa aagactcagc 1496101 tgaaagctga gtcttttttg tgttctgtat ggttaagcgg ccgctttatt ttttgacttt 1496161 ttcttttttc tgctgtcccg ggtgaaaagt aaattttccc gttttcagcc gttcctctgt 1496221 ttttttggca atccgatcgt ggcattcctg gcacatatat gtatggatcg ggcggtttcg 1496281 aagccgtttc gcgatcaggg tatcatcatc aattgtttca attttatcgc aaatagaaca 1496341 tttgaccctc atcatatcac ctctttcact aacatgtatt ataccacgga tcagaagctg 1496401 tccaaaataa gaaaaagcta aagcgcaagg ctatagctta gtcattgttg ttctttttca 1496461 tatgatgatc agattgatcg ttttgttcct tctccatttc ctgttgctgt tttctattta 1496521 attggtcatt ttgctgcttt gtttgcggtt catcttcatt gtcaatcaca tcgttaggca 1496581 cttcgggaag cactcggccg acaattgcag ctaattcatc cagtatacct gttaccggat 1496641 ggccctcgct gatttctctg ctcatttcgc gaaggcggct gaccgtatcg ggatcagcaa 1496701 tgactactgc gttggcgcca tatcgatcat tctttagcgc ctgagctaca gaatatttaa 1496761 tggtttccac tttgcttctg tccaaagtat catcgacatc aatcccaaca acagcatagc 1496821 ctcccagcac aacggctgtt gcatccttga cgtcggggtt tttttcagca acgctgacaa 1496881 gatgcttggc aatatccgtt cttgttccat tgtcttttgt ttcttgagtt gtgtccttta 1496941 cgtgaatcgg tttagtctcc tgctgtcttg ttgattcttt ttcaacattc tggccctgtt 1497001 ttccttgttg ataggcacaa gcggacagga taagtgtcag ctgtatgata atgaaaagaa 1497061 ttcgcacttg cgggttccct ccttaaaatg ctttcattaa ttttattgtt gaattaacct 1497121 tctatcttta tgcacaaaaa catatatttt agcaggcatt cacctttttc atcaaaagag 1497181 aagcaggaag aactttgacc cttatatcag gaggctgaga cttgagtaaa atttatgtgt 1497241 tagatacgaa tgtgttatta caggatccta acgcgatatt ttcttttgaa gaaaatgagg 1497301 ttgtcatccc tgctgtcgtt ttagaagagg ttgattcaaa aaaacggtat atggacgaag 1497361 ttgggaggaa tgcaaggcac gtatctaagc taatcgatgc gctaagacaa aagggcaggc 1497421 tgcatgagca tgtaccgctt gacaccggcg gcacactgag aattgaactg aatcatcgtt 1497481 cgtttcacca gctgcaagag atctttattg aaaagacgaa cgataatcgc atattagccg 1497541 ttgcgaaaaa cttaagcctc gaggaagaaa ccaaggaaaa tggcaggccg gttatccttg 1497601 tcagtaagga tgtactggtc agggttaaag ccgacgcaat cggactgctt gctgaagatt 1497661 tcttgaatga ccgggttgtg gacaatgatg aaatgtacag cggctataaa gatttatata 1497721 tcagccagca gctgttcagc tctttttacg ggaaaaatca aatttcagta aacgatgtga 1497781 aacagcatgc gttttatccg aatcagtttg ctttaatgaa ggatgagcta ggagggtcct 1497841 cctcggcagt cggaattgca gacaaaaccg gaacggtatt aaaaagactc gtatttgatg 1497901 atgaacatat atggggaatc aggccgaaaa atgtacagca gacaatggca ttagagcttt 1497961 tgctgcggga agatattccg cttgtcaccc tgatcggcaa agcgggaacc ggcaaaacgc 1498021 tcttagcttt ggcggcaggg ctattacaga cagaagactt gggaatatat aaaaagctgg 1498081 tcgtcgcaag gccgattgtt cctgttggca aggacatcgg gtatttgcca ggcgaaaaag 1498141 aggaaaagct aaagccttgg atgcagccga tttttgacaa cttagagttt ctgtttaatg 1498201 cgaaaaaacc aggggagctt gatgctattt tggcgggaat tggctcaatt caggtagagg 1498261 cgctgactta tatcagaggg agaagcattc cagatcaatt tattatcatt gatgaagcgc 1498321 aaaatttgac caggcatgag gtgaaaacgt tgctgacgag agtcggtgag ggcagtaaaa 1498381 ttgtcttaat gggcgaccct gaacaaattg atcacccata tttagacagt ctgaacaatg 1498441 gtttggccta tgtggttgag cggtttaaag gacaacccat ctcaggcagc gtgaagctgt 1498501 taaaaggtga gagatcaggt ctcgcccagc ttgcagctga tttgctgtaa cacttaaatg 1498561 atttcgatct cttttacatc ggtaatcggc tgtttgtgat gaaccgggtc ttcaaagtaa 1498621 atatgcacgg ggccgccttc ttgaatcggc ttgcctgcct cactgaaatg gacaatactg 1498681 ttcagagcgg tttccagaga aacggcggcc tttcccgaac ttgtgacaaa tacacattgt 1498741 gtcgcagagc tgttcggctc agcatttttc aggacagtcc caagtctcat tgcgaaactg 1498801 ccgttcatca gtttttgctt ctcatattgc ttttccgtct ttaatgtagg cggcgcgatt 1498861 cgcccctctc tgatgacgcg ttccggatca aggtcggatt catccccggc tgattgtaaa 1498921 tatgtgtctt gactgtcccc tttgcggtca aacgaaaatt tgcgatcatc aaaaatccat 1498981 acgcttggat caatggtaat tggatatgta acattgcctt ttacttggat aacgctcatg 1499041 atatgacccc cttctctcaa aattataaaa gttttcgcat gaattgtcac tttgtgtaca 1499101 aattatgtgt attgaaatgc tgagggaacg agggtgtttg catggtatgc cagcataatg 1499161 atgagcttga agccttagtg aaaaaggcga aaaaagtaac ggacaagggg gaggtagcca 1499221 gctatattcc cgccttggca aaagctgata aacacgacct gtcagtggcg atttattatt 1499281 ccaataatgt ttgtctgtca gcaggtgacg tagaaaaaac atttacgctt caaagtatat 1499341 cgaaagtcct ttcccttgct ttggtgttaa tggaatacgg caaagataag gtcttcagtt 1499401 atgttggaca ggagccgacc ggtgatccgt ttaattcaat tatcaagctc gaaacagtga 1499461 atccgagcaa gccgttaaac cctatgatta atgccggggc attggtagtg acaagtctga 1499521 taaggggaag aacggtaaaa gagagacttg attatttgct ttcttttatc agaaggctga 1499581 caaacaacca agagattaca tactgccggg aagtggctga atctgaatac agcacttcaa 1499641 tgattaatcg ggcgatgtgt tattatatga agcagtacgg catttttgaa gatgatgtag 1499701 aggcagtaat ggatttatat acgaagcaat gcgcgattga gatgaacagc ttggatttag 1499761 cgaaaatcgg atctgtattc gcattgaacg gcagacatcc agagactggg gagcaggtca 1499821 tctcaaaaga tgtcgctaga atttgcaaaa cgtttatggt gacgtgcgga atgtacaatg 1499881 caagcgggga attcgcaatt aaggtcggaa ttcctgcgaa aagcggcgta tccggcggga 1499941 taatgggcat ttcgccttac gatttcggga tcggcatatt cggccccgca ttagacgaaa 1500001 aagggaacag cattgcaggt gtaaagcttt tggaaataat gtctgagatg tacaggctga 1500061 gtatttttta atttatgtca tatgcttaaa tcctcttgca ttttctgttg atacccttta 1500121 tgataaatag aagaattagg tactcgcctg gggaacggag ggatactttt ggcttcagag 1500181 atgatagttg accatcggca aaaagctttt gaactcttaa aagtggacgc tgagaagatt 1500241 ttgaagctga tccgagtaca aatggataac ttaacgatgc ctcaatgtcc tctatatgaa 1500301 gaggttttag atactcaaat gttcgggctt tcgagggaaa tcgattttgc tgtccgcctg 1500361 ggattggttg atgaaaaaga cggtaaagac cttttataca cattggagcg cgaattgtct 1500421 gctttgcatg acgcgtttac agctaaataa atgataaaac tcaaacttat taacagtttg 1500481 ggttttttta taaccgctat ttttctctca tctcataaaa gacggtcttt ttttacacat 1500541 tccttccgaa tcgtatagag attcttcgtc tcgtttgata aattgtagta aaataaaaaa 1500601 gataaataca taaaaaccat agataatgga agttagaagc agggaagagg atgttatgtt 1500661 aaaaaaaatg ctaaaatctt atgattactc actgatattc gcaatcgttt tattatgcgg 1500721 attcggttta gtgatggtat acagctcaag catgattacg gctgtctccc ggtatggagt 1500781 aagcagtaat tttttcttca tgcggcagct gtttgcttta attgcgggtg gcgctctatt 1500841 tattctcatg gcgttgtttc cttataaagc actggcccat caaaagtttc agaaggggat 1500901 actgcttgta tctgttcttg cgcttatctc actgtttgtt ttcgggcatg ttgccggaaa 1500961 cgcgcagagc tggtttaaaa tcggcggaat gagtattcag ccgggggagt ttgtgaaact 1501021 ggtcgtgatt ttataccttg cagccgtata tgcaaaaaaa caaagttata tcgaccatct 1501081 gttaacggga gtagcccctc cggtagtcat gacgcttata atttgtgggt taattgccat 1501141 gcagccagat ttcggtacag ccatgattat agggttaatt gcgacgtgca tgatcttgtg 1501201 ctccggcttc agcggaaaga cgctggtgag gcttgtgata ctgggcggaa ttgttttcat 1501261 tttagtcagc cctattatct atttgaatca ggacaaaatt ttaactgaag gccgtttagc 1501321 gcgttttgag agtcttgaag acccatttaa gtatgcaaat tcatcaggtt tgcaagtgat 1501381 caattcttat tatgcgatca gctcaggcgg cattttcggc ctggggctcg gtgaaagtat 1501441 ccaaaaatac ggatatctgc ctgaatcaca cactgacttt attatggctg tcattgctga 1501501 agagctcggc atttttgggg tattgtttgt gattttctta ttgggttttg tcgtcataaa 1501561 aggtttttat attgccagaa aatgcgagga cccgtttgga agtcttctgg cgatcggcat 1501621 ttcaagcatg attgccatcc agtcgtttat taaccttggc ggtgtcagcg gattaattcc 1501681 gattacaggg gttacgctgc catttatcag ttacgggggc tcttctttgg tgctgctgct 1501741 ggggagtatg gggatattag cgaatatcag catgtttgtg aaatattcag agaataagaa 1501801 aaagaaagag cccttggcgc cgaagggaat gaaaaagaaa cagctcaaaa aaactgttta 1501861 tctgtaaaaa acaagtgtgt acaggggaag gatattccgc tatgatagat tatattccat 1501921 tcgggtaagg gggagaaaag tttgtctcag caatcgatac aaaaagtatt agtagcaaac 1501981 aggggagaaa ttgcaatccg aatattccgg gcgtgtaccg agttgaatat tcgtacagtt 1502041 gcggtctatt caaaagaaga ttccggttcc taccatcggt acaaagcgga tgaagcatac 1502101 ttggtcggtg aagggaaaaa accgattgat gcttacctgg atattgaagg tatcattgat 1502161 attgcgaaaa gaaacaaagt cgatgcaatt catccgggat acggtttctt atctgaaaat 1502221 attcattttg cgagacgatg tgaagaagaa ggcatcgtat tcatagggcc aaaatccgag 1502281 catctcgata tgtttggtga caaggtaaaa gcgcgtgagc aggcagaaaa agcgggaatc 1502341 cccgtgattc cgggaagcga cggtcctgcc gaaacgcttg aagccgtcga acaatttgga 1502401 caagctaacg gttatccgat catcattaaa gcctcgcttg gcggcggcgg ccgcggtatg 1502461 cggattgtca gatctgaaag tgaagttaaa gaagcatatg agcgtgctaa atcagaggcg 1502521 aaagcagcct ttggcaatga tgaagtttat gtagaaaaat taattgagaa tccgaaacat 1502581 attgaggttc aggtcattgg agacaagcag ggcaatgtcg tccatctttt tgagagggat 1502641 tgctccgttc aaagacgcca tcaaaaagtc attgaagtgg cgccgagtgt ctcgctgtca 1502701 cctgaattaa gggaccaaat ttgtgaggct gcagttgcgc ttgccaaaaa tgtaaactat 1502761 ataaatgcgg ggacggtcga attccttgtt gcaaacaacg agttctactt tattgaagta 1502821 aatcctcgcg tacaagttga acacacgata acagaaatga ttactggtgt cgatattgtt 1502881 caaactcaga tccttgttgc ccaagggcac agccttcaca gcaaaaaagt aaatattcct 1502941 gagcaaaagg acatttttac aatcggctat gccattcagt cacgggttac gactgaggat 1503001 ccgcaaaatg atttcatgcc tgatacagga aaaatcatgg cttaccgctc aggcggcggt 1503061 tttggtgtcc gtcttgatac cggaaacagc ttccagggcg ccgtgatcac accatactat 1503121 gattcacttc tcgttaagct ttcaacttgg gctttaacgt ttgaacaggc agctgccaaa 1503181 atggtgcgaa accttcagga gtttagaatc agaggcataa aaacgaacat tccgttcctt 1503241 gagaacgttg caaagcatga gaagttcctg acagggcaat atgatacatc tttcattgat 1503301 acaacgcctg aattatttaa tttccctaaa caaaaagacc gcggaacgaa aatgctcact 1503361 tacatcggca atgtgacagt gaacggcttc cctggaatcg ggaaaaaaga aaaaccggcg 1503421 tttgacaaac cgttaggcgt aaaggtagac gttgatcagc agcctgccag aggaacaaag 1503481 caaattctcg atgaaaaagg tgcagaaggg cttgcaaatt gggttaagga gcagaaatct 1503541 gtccttttaa ctgatacgac attcagggat gcccaccaat cgttattggc aactagaatc 1503601 agatcgcatg atttgaaaaa aatcgcaaat ccgacggctg cgttatggcc tgaactattc 1503661 agtatggaaa tgtggggagg cgcgaccttc gatgtagcct accgattcct gaaagaagat 1503721 ccgtggaaac gtttggaaga tcttcgcaaa gaagtgccga ataccttatt ccagatgttg 1503781 cttcgctcat caaatgcggt cggctatacg aattatccgg acaatgtgat taaagaattt 1503841 gtgaagcaat cagctcaatc cggtattgat gtgtttcgta ttttcgacag cttaaactgg 1503901 gtaaaaggga tgacgttagc cattgatgct gttagggata ccggcaaagt ggcagaagct 1503961 gcgatttgtt atacgggaga tatccttgac aagaaccgga cgaagtacga ccttgcatat 1504021 tatacatcga tggcgaagga gcttgaggcg gccggagccc atattctcgg gattaaagat 1504081 atggcagggc tgttaaaacc gcaggctgca tatgagctcg tttctgcgtt gaaagaaacg 1504141 atcgacattc cggttcacct tcatacgcat gatacgagcg gaaacggtat ttatatgtat 1504201 gcgaaagctg ttgaagccgg cgttgatatc atagacgtgg cggtcagctc aatggcggga 1504261 ttaacgtcac agcctagcgc gagcggattt tatcatgcga tggaaggcaa cgaccgccgt 1504321 ccggaaatga atgtccaagg cgttgaattg ctgtcccaat attgggagtc ggtgcgtaaa 1504381 tattatagtg aatttgaaag cggaatgaag tctccgcata ctgaaattta tgaacacgaa 1504441 atgccagggg gccaatacag caacctgcag cagcaagcca agggagtagg ccttggcgac 1504501 cgctggaacg aagtcaagga aatgtacaga cgcgtgaacg atatgttcgg tgacatcgtc 1504561 aaggtaacgc cttcctcaaa agtagtcgga gatatggcac tctacatggt gcaaaacaat 1504621 ctgactgaaa aagacgttta cgaaaaaggt gaatctttag atttccctga ttctgtcgtg 1504681 gagcttttta aaggaaatat cggccagcct catggcggat tcccagaaaa actgcaaaag 1504741 ctgatcttaa aagggcagga gccgattaca gtcagaccgg gcgaactgct tgagccggtg 1504801 tcatttgaag cgatcaaaca ggaatttaaa gagcagcata acttggaaat ttcagatcag 1504861 gatgctgtgg catatgccct ttatcctaaa gtcttcactg attatgtgaa aacgacagaa 1504921 agctatggag acatctcggt attagataca ccgacattct tctacggtat gacattaggt 1504981 gaagagatag aagttgaaat tgagcgcggc aaaacgctga tcgttaagct gatttcaatc 1505041 ggtgagcctc agcctgatgc cacccgcgtc gtttatttcg aactcaacgg gcagccgcgt 1505101 gaagtagtca ttaaagatga aagcattaag tcttccgttc aggaaaggct gaaagcagac 1505161 cggacaaatc caagccacat cgcagcttcc atgcctggaa cagttattaa ggtattggct 1505221 gaagcaggca caaaagtcaa taaaggtgat catttgatga ttaatgaagc gatgaaaatg 1505281 gaaacaacgg ttcaggcgcc tttctcagga acaatcaagc aggttcatgt gaaaaatggt 1505341 gagccgatcc aaacgggaga tctgctcctt gaaattgaaa aagcataaaa aacaaagagt 1505401 gtatatcaat gatatacact cttgtttttt atatagaaaa tgtggagtga aacagatggt 1505461 tagaagagat ataaggggac ttcagagatt atagagtact gtcacaagcc caaaataaaa 1505521 agaggcttat acagccaata ttttagatgc tttgtagtat gccgtgcata tttctttaag 1505581 cactatctga tttaaaaggc tttaatactt atgttcgcga gctatagatc catatgaaat 1505641 ttctataatc acgatgagaa aggggacaga ccgaagtgag ccgctcactg atcatcaagt 1505701 tcggcgaagg ctggcgattg aaacgcataa agcgccaaaa aacaagacat aaaaaagacc 1505761 aaagccgcct aaggctttgg tcttgagtcc ttatgattgc ctggattcat aacggaaacg 1505821 agcaatcaat aataagaagt agcatagaac gccaaacaga caggcaataa agaacgagtg 1505881 ggcaagtgca aagcccagag ccagttcaga gtatacgatc ataataccgg acagtgcctg 1505941 taatgtaatg aaaataagac atgagatcca tccccaaaag atctgttttt gatctttata 1506001 ggaagtaata gcatgaacag cggcaacaat aatccataca aataaaagta aggctgctgc 1506061 tctgtggccc atttgcaccc attcatggaa ttgggtcgga agtccattgt tcagcgggct 1506121 gcacagcggc acattaggac atgccagact tgattcagtg tgtcttacat atgcgcctgt 1506181 atacacaacg atataggaat atattaaaat tcctatcatg tgaaattgca tctttttgcc 1506241 gatttgaagc ggcttaacca gtgttctgac tgatttatca gcttcaaata tgagcaatgt 1506301 taaaataagc actgaagcaa aagaaattaa tgagatgccg aagtgaagcg ccataatcag 1506361 cgcgttcgaa ccgaatacga cagccaatgc gccaagcaat gcctgaagaa ataaaaagat 1506421 aattgacatg atcgcgagaa acgttgtttc acgaaaaatc ggcgtgattt ttctccatga 1506481 ccaaaacgca aggcttagca caaggataat agagattccg cttgcgaatc ggtggctcca 1506541 ttcaataatt gaagccggat tcagttcagg gaaaaaacgg ccgtgacaca gcggccactg 1506601 tctgccgcat ccttggccgg aacctgtttt tgtaacgagg gcacccccga ttaaaacaat 1506661 tagcatgaca aatgtcgtca gaacaccgag agcttttaat gctttattca tacaatattc 1506721 accttcttaa catactgctg caattttata tacgttccaa gtgtaagcga atatgtgttt 1506781 tgtggcaatt cccagagcct tttgttcaca aaaatataat agaatgacgg cttctggaaa 1506841 atgtacactt gattattcat gccgggtctg atagaaataa ggtaaacgca atgccgattt 1506901 ggagattgcc ttcatctttg gtaaaattca taaaaagttc acaaataaat tcctgtttgt 1506961 cgtttaatat ttaataggat gtttttttac aagatgttat cttgtatgat agagttgcag 1507021 gttattttat tctcctgcgt taggtttgta agggaggttt acgttatggc taactccaga 1507081 atcttaaatg atacagctat agacggacaa attgaagaaa caacggcatg gaaagatttt 1507141 ctgtccctta ttaaaatagg gatcgtcaat tctaacctca tcacgacttt cactggaatg 1507201 tggcttgcac tgcatatatc cggtttaagt tttttaggca atataaacac cgttcttctt 1507261 acgttaatcg ggtcttcact gattattgcg ggctcctgcg cgatcaataa ctggtatgac 1507321 cgggacattg accatcttat ggagcgtacg aaagtaagac cgacggttac gggtaaaatt 1507381 cagccgagtc aggcgttatg gtctggaatt ttgctggttg ctttaggatt gatcatgctg 1507441 ctgatgacaa ctgtcatggc tgctgttatc ggttttatcg gagtctttac gtatgttgta 1507501 ttgtacacaa tgtggacgaa acgccgctat acgattaaca cagtagtagg aagcgtttcc 1507561 ggtgcagtgc cgccgcttat tggatggacg gcagtggaag ggaatatcgg tgtcgtagca 1507621 tgggtgttat tcatgatttt atttatttgg cagattcctc acttcttagc attggctatt 1507681 aagaaaactg aggattacag agctgcaaat attccgatgc ttcctgtcgt atacggattt 1507741 gaagtgacaa aaagacaaat tattgtgtgg gttgcgtgcc tgatgccgct tccgtttttc 1507801 cttggtagcc tgggtcttcc gattgtcatt ctcggcttgc tgttaaatat cggctggctg 1507861 attcttggct taatgggatt ccgctccaag aatatcatga agtgggcaac gcagatgttc 1507921 gtttactcgc ttaactacat gacaatctat ttcgttgcca tggttgtctt gacgcttttc 1507981 taaaaaatag atatgatgct tgttttatcg cttcaaaata aacgatgaca actagtaaat 1508041 gccgccttga cctcttgttt aatcaggcgg ctttactttt atacatagat ggcattttga 1508101 gtaaaaaaac tcataattta agagaagagg aaatgtaagt gctttattgg tgataggttg 1508161 gatggcgata gatttcgatc cgctttccgc ctttgtattg accagaaaag gggttgggtg 1508221 aaatggtaaa gcattggcgt cttattttat tattagcctt agtgccgctt ctattaagcg 1508281 gatgtggaaa acctttttta tccacgctca agcctgctgg cgaggtggct gataaacagt 1508341 atgacctgac agtgctcagc acattgatta tggtggttgt tgttgcagta gtatctgtta 1508401 tcttctttta tgtgattgtg agattcagaa gatcacgggt cggtgagaac acgataccga 1508461 aacaggtaga ggggaataaa tttttagaaa tcacatggac cgtgatcccg attttgctgc 1508521 tcattattct tgtgattcct gttgtattat atacgctgga gctagcggac acatcaccaa 1508581 tggataaaaa aggccgcaaa gctgaggatg ctcttgtagt caatgttagg gcaaatttat 1508641 actggtggga gtttgagtac cctgattacg gcattatcac aagccaggag ctgattgtac 1508701 cgacagatca gcgtgtatat tttaatttaa aagcctctga tgtaaaacat tccttctgga 1508761 ttccttcagt tggaggaaaa cttgatacga atacggataa tgaaaataag ttcttcctga 1508821 catttgattc aaaacgaagc aaagaggcag gagatatgtt ttttgggaag tgtgcagagc 1508881 tttgcggccc ttcacatgcg ctgatggatt ttaaggtgaa gacgatgtct gcaaaagaat 1508941 ttcagggctg gacaaaagaa atgaagaact ataagtctac agcagagagc gatttggcta 1509001 agcagggtga agaactgttt aaagagaaaa actgcctgag ctgccatgcg gtagagccga 1509061 atgataagcg tgcagaagcc gctagaacgg cacctaactt ggcgaccttc ggtgaaagga 1509121 caaaagtggc aggggtgaaa gaggccaaca aagaaaatgt gaaggcttgg ctgaaggacc 1509181 ctgacagcat aaagccgggg aacaaaatga caggcacata tccaaagctc tcagacagcg 1509241 aaacaaatgc gctttatgaa tacttaaaag gcttaaaagc ggaaagcaag tagggaagaa 1509301 agggagatat tgggggaggt cacatatgtt gaatgcgctt acagaaaagc ggacgcgcgg 1509361 atctatgctt tgggattatt tgacgacggt ggaccataaa aaaatcgcaa ttctttattt 1509421 agtggcaggg ggattcttct ttcttgtcgg gggaattgaa gcgatgttta tcagaattca 1509481 gcttgcaaag ccggaaaatg cgtttctcag tgctcaagcg tacaatgaag taatgactat 1509541 gcacggaacg acgatgatct ttctggctgc gatgccgctc ttatttgcct tgatgaatgc 1509601 ggttgtgcct ttgcagatcg gggctcggga cgtttcgttt ccatttttaa acgcgcttgg 1509661 tttttggctc ttctttttcg ggggcatttt cttaaatcta agctggtttt tgggcggagc 1509721 gccagatgcg ggctggacat catatgcctc actttcgctt cattctaaag ggcacggcat 1509781 agactttttc gtcctcggac tccaaatatc ggggctcggg acgctgatag ccgggattaa 1509841 ctttttggcc acgattatca acatgagggc tccgggcatg acgtatatga ggctgccttt 1509901 gtttacatgg acgacatttg tggcctcggc attgattttg ttcgcgtttc cgccgcttac 1509961 ggttggattg gctctcatga tgctggatcg gctgttcgga accaatttct ttaatccgga 1510021 gcttggcgga aatacggtca tttgggaaca tttattttgg atcttcggcc acccggaggt 1510081 ttatatccta attttgcctg cattcggtat tttttctgag gtcatccctg tgttcgccag 1510141 aaagcgtttg tttggctatt cttcaatggt ttttgcaatc gtgctcattg gctttctggg 1510201 ctttatggtt tgggtgcacc acatgttcac gactggtctc ggcccgattg caaatgcgat 1510261 ttttgcggtt gcaacaatgg ctatcgcgat tccgaccggg attaagattt ttaactggct 1510321 gttgacgatt tggggaggaa atgtgaagta tacaaccgct atgctgtatg ctgtctcatt 1510381 tattccatcc tttgtgctcg gcggtgtgac gggagtcatg ctggcagctg ctgcggctga 1510441 ttatcagttt catgatacgt attttgtggt tgcgcacttc cactacgtca ttattggcgg 1510501 cgttgtattc ggccttttag ccggtgttca tttctggtgg ccgaaaatgt tcggtaaaat 1510561 tctgcatgaa acgatgggga aaatttcatt tgtattgttt tttatcggct ttcacctcac 1510621 gtttttcatt cagcattttg tcggcttaat ggggatgccg cgccgggttt atacgttttt 1510681 gccaggacag ggtctggaaa ccggcaactt gatcagtaca atcggggcgt tttttatggc 1510741 ggcagctgtt attcttctgc tggtcaatgt catatggaca tcggtaaaag gtgaatatgt 1510801 aggtgctgat ccatggcatg acggacgtac gctggaatgg accgtttctt caccgccgcc 1510861 ggagtataac tttaaacagc ttccttttgt cagaggactt gatccgcttt ggatcgagaa 1510921 gcaggcaggg cacaaatcaa tgacgccggc ggaaccggtt gatgatattc atatgccaaa 1510981 cggctcaatc ctgccgctca tcatttcctt cggccttttt gtcgcagcgt tcgggctgct 1511041 gtacagaagt gattacgctt ggggcctgcc ggtgatcttt atcgggctcg gcatcacatt 1511101 tattacgatg ctgcttcgtt cagtaattga tgatcacggc tatcatattc ataaagagga 1511161 actgccgaac gatgataaag gggtgaaggc ataatgcaag ttcaagaaaa attcaccgca 1511221 gaaacctttc cagcttctcc tgaaaaagta accctggaag ggaaaaataa atttttaggc 1511281 ttttggcttt ttcttggcgg agagactgtt ctgtttgcgt ctctcttcgc cacgtttctt 1511341 gcgcttcgga attcaaatgc cggtgatccg cctacgacgg aaatgttcga tgtgacactt 1511401 gtattcattg ccacaatgct tctattaacg agcagtttaa cgagtgtgta cgcgatgtac 1511461 cacatgaaga acttttcctt cggcaagatg cagctttggc tgggaattac gattttattg 1511521 ggggcgggct ttttaggact ggaaatctat gagttcaagc attacaccca tgaatttggc 1511581 tttaccatca caagctctgc ccttggttct gcgttttaca cgcttgtcgg tacacacggc 1511641 gcccacgtgg catttgggct tatgtggatc agcacgctta tgatccgcaa tgccaagaga 1511701 gggctgaatc tgtatacggc gcctaagttt tacgttgcca gcctttattg gcactttatt 1511761 gatgtcgtgt gggtcttcat ctttaccgtt gtatatttaa tggggatggt gggataaaca 1511821 tggtcgataa aaaaagcaga gggcatatca atagcgacct tgaatttaag aaaaaaaagc 1511881 atgcccggga gatgaaatat caagtcctgt cttttggttt aatgatcggt cttacgattg 1511941 ttgcatttct gactgtggcc acggacggtg tcggcagctg gtttacgatt cctttcatta 1512001 ttttgctagc tgcaattcaa gtcatttttc agctgtatta tttcatgcat atgaatcaga 1512061 aagggcatga ggcgccggca ctgtttttgt attcaggggt gtttgtcgcg tttatcactg 1512121 tgcttgcgtt tgtgacaatt atatggtggt aatttgaaca gccgccggag gtgaagaaat 1512181 gaatcagttg gagatatttg ggtttcgcgc gatgtggagc ccttatcttt tttgtatcct 1512241 gttaggcatt acggcgcttt atctctattt ttacaggcga atgtcttcaa agccgaatcg 1512301 aataactggt aaagagatgg tgtgctttct gtcggcgatg ctgtttttat atgcagccga 1512361 gggaagcccg gttgatctgc tcggacatat tatgttcagt gcgcatatgg tgcagatggc 1512421 cgtcctgtat ttggttgtcc cgccgctgtt aatcgcgggg attcctgcat ggctctggga 1512481 aaaaatcatt ttcaggcctt caatcaaacc ggttttttcc ttttttacga cgcctttaat 1512541 tgctttgctt ttgtttaacg gcattttttc tttatatcat gtaccgctta tatttgatac 1512601 tgtcaaaaca gatccgtttt accatacatt aatcacttgg cttatctttg tgcttgcgtt 1512661 cttcatgtgg tggccgcttg ttcataaggt tgagcgtcta cggcagctca gcggcttgat 1512721 gaagctgggt tatattatgg cggacggtat gctgctcaca cctgcttgcg ccttgatcat 1512781 gttcagcggt gcaccgttat acgccaccta tacagatccg gctttatggg ctgaggcaat 1512841 gaggctttgc gtgccagcgg atatgatggg gcaggtccca ttaacagggc cagagatgtt 1512901 gaatacactg cctttgttag aggatcagca gctcggagca gtcatgatga aaatcattca 1512961 ggaaattgtg tacggtactt ttttggccgt tatttttttc caatgggtga agaaagaaag 1513021 ggaaaaggac gggcaggagg agccgccgta tattcagcag acgatatcat aaaaggtaca 1513081 gcgaaatatg ctgtaccttt tcgttacatt tgaactgttt ttaacatgtt ggctatgtcc 1513141 tgaatcagtg ccttgctttt tgtcacaacc tgtacgggaa actcttccgt ttctccatat 1513201 tctactccat gagggtagta atgctttcct aggagagggg acattaattg aatcacggcg 1513261 cgcccgcttc cgacatcgcc ttctgccgca ataccttgta tccgcaggta aaacgtaccc 1513321 tcaatcgtcg aaaacttctt gtcataggtg actctctcgt aatcccattg acccgctctg 1513381 ataagacctt tgctttccat taagtcgtct agccagctga gctcagcctt aaccccttca 1513441 agtccgcttt cagtaaactt caacactgac ccctccttat aaaaattacc tttcctgaca 1513501 atcatagtat gaaagcgtta aactttcaat gaatcttctt cttttgaaag tatgcaaaaa 1513561 ttaaattttg acgacaatag cactagacta aaggaggtta aacggatgac aaaaataaaa 1513621 gatctgatga cagccgactt gcaatattgc acggtattag ataatgtata tgaagctgca 1513681 gtaaagatga aggacgcaaa tgtaggagcg ataccggtag ttgatgagga cggggaaaca 1513741 ttggtcggca tcgtaaccga ccgcgatctc gtattaagag gaatcgccat caaaaaaccg 1513801 aactcgcaaa aaatcactga cgcgatgact gaaaaacctg tcagtgtgga ggaagatgct 1513861 tcagtcgatg aggttcttca tttgatggca tcgcatcagc tcagaaggat accagttaca 1513921 aaaaataaaa aactgactgg aattgtcacg cttggtgatc tttctttatc tgagcaaacg 1513981 aatgaacgtg ccggcagcgc cttatcggat atttccgaag gggataatag agaagaaggc 1514041 ttttttcatt aacacataaa tctttgacat gttaaatagg ctgtattgta atgggatgta 1514101 aacaagagat tgtgaatcgc cacgggggtg atagattgaa aaatatattg agagcaatgg 1514161 ttatcctttt gattatctgc ggaacctatg ttctgtttat tcaatatgga tctgttcctg 1514221 aaaagaaatc aaatgacagc gagcctcagg tgtcgaatga ggaagcgcaa agcggcaaac 1514281 gaatacatat gccgacttca gggttattgt ccttcatggg caagcacgcc gatgaagtaa 1514341 cgaaaaagct tggggaacct gaacgtattg acccttcggc ttatgattac gattggtggg 1514401 tatacaatca aggtaaggat caatatatcc aaatcggggt attaaacaat aaagtggtca 1514461 cattattcgc gtcgggtaat gatattaacg ccaagccttt caaaattgga gaatcaactg 1514521 gcgaagtatt caagaccacc caggtggcac catttgtgaa tgtagagtat aaaggaaatt 1514581 cctatcggtt tgaattttct gaagaagata tcaatacaag accgactgta aaggtaggaa 1514641 agatgtatgt ccagctgtat atggacaaat ttgaggggaa gctatccagc atcagggcgt 1514701 ttgatgcgca gacctttgta aagcaaagac cttatgaggt agtgtaccgc ggggaattaa 1514761 ttaaaccgaa agccgtttca gatgagaaat ggaaaaagat ccaaacaacg agcgaaaagc 1514821 aaatccttga tttgacgaat gtcatacgcg ttaaacatgg acttgcgaag cttgagtggg 1514881 atcagccaac ggcggaagtg gcatttgggc atagtgagga tatgaaggaa aataattatt 1514941 tctcccatgt ctctaaaaaa tacggctcgc tgaaagaccg cttagaagaa gggcatgttg 1515001 attttcagca agcgggagaa aatatcgcat acaattatgt ggacggtccg gctgctgtag 1515061 aaggctggct gaatagcgaa ggccatcgaa aagcgcttct gaattcagat tatacgcatc 1515121 ttggtgtcgg agtagaccgg aaatattaca cccaaaactt tattaagcga tggtaatgaa 1515181 agccgcggac gaatggttcc cggctttttc tatttccata caagctggtc tgaatgaatg 1515241 tgctgatagc ttacagataa ggccgtttcc catcccttca gtcaggcttt ttcaccagtg 1515301 tatagggata tcgctaaaaa ttcatttggg aatgaatata ggcgaacaca atgcccgaca 1515361 aaacgataca ttgtagtagg taacgatttt cggagggggt gaggattgtg gcgaatcaac 1515421 atgccaatca ttcaatcaat gactttaaac aattcgtcaa aaagcatccc aagctgataa 1515481 aagaagtgcg caaagaacaa agaagctggc aggacgtata tgaaaattgg gtcctcttcg 1515541 gggagagcga cccgatttgg gatccatatc gggaaccgga agaagcttct gaagctgtgc 1515601 ctgaaacacc gcaaaaaaat gattttgtct cgaaaatggt gacagcggtg aaaaagatgg 1515661 atgtcaatca aatgaacgaa caaatcaata aaatgagcca gtcgatctca tcgttgcaaa 1515721 gccttcttaa tacattttcc ggaagcggac agaagcattc tcagccaggc tctggacagc 1515781 atcctttttc ttttcgaaag gattaaaaaa ggggagctca tatgcgcaaa gaggttcagg 1515841 aatatatttt agcaaacgaa gaacggaaac gattcatcag agaacagccg atatggtacc 1515901 gcaggctttc aagaaaaccg gatgatctgt cctcctttca gcttgaaatg atgaattttt 1515961 atgaaaaaac cattccgcat cgggtgaatc agtttacgaa cgggattcaa atggcgcaaa 1516021 tgatgatgca aatgtttcaa gcgatgcgga caaaagatta aaaggccccg aagaagggtc 1516081 ttttttcatg cggtcataag gttttgttgg cggctgcggt taagcatttt ccaattggct 1516141 ggtttcatgg taaactaaca actggaggtg catgttatgt atgcgacgat ggaatccgtg 1516201 cggcttcaaa gtgaagctca gcagcttgcc gagatgattc tgcagtcgga gacggctgag 1516261 aactaccgca attgttacaa gcgtctccag gaagatgaag aggcaggtcg gattattcgt 1516321 tcttttatca aaataaaaga gcagtatgag gatgtacagc gttttggcaa atatcatcct 1516381 gactatagag aaatatcccg gaaaatgagg gagatcaaac gtgagctgga cctgaacgat 1516441 aaggtggctg acttcaagag agctgaaaat gagctccagt ccattcttga tgaggtcagc 1516501 gttgagattg ggacagctgt ttcggagcat gtgaaagttc cgactgggaa cccttatttt 1516561 gacggtttgt cttcatgcgg aggcggctgc ggttcaggcg gaagctgcgg atgtaaagtg 1516621 tcctgacgag actggccgtc tcgtctttta catataagag aaaacaggca ggtgattgta 1516681 ttggagaata ggcgccaggg catggttgtg tatctgcact ccctaaagca gagcaaaatg 1516741 ctgaggaagt tcgggaatgt gcactatgta tcaaaacgat taaaatatgt cgtactgtac 1516801 tgtgatatgg accaaattga aaaaacaatg gacaagattg cgtcttactc atttgtgaaa 1516861 aaagtggagc cttcttataa accgttttta aaattggaat tcgagtcaaa gcttgataag 1516921 gcaaaagaat acgattataa aatcggcata tagctataaa aaaatccccg caggcatctg 1516981 cggggtcctt ctattcctta atatgttaag gagaaggcaa agggagagga gaaaccggag 1517041 gaagaactta tggggaaacg taagtcttct ccgcggttgg caacaacatc ctctagatgc 1517101 tgttgcttat agtatggaca aggatcatgc tgcctataca cctgtttatc aagattagcg 1517161 ttcattgttt ggaagaatgc tttatgttaa gataggattg atttttttct atgtacatag 1517221 cggcgtccgg ccgaataaag aaacaaaata gcttttagaa aaagtggtgt ggaacatgag 1517281 agtaatttct ggatcaaaaa aaggccgttc actaaaggct gtagccggaa catcaacaag 1517341 accgacaacc gacaaagtga aggaatccat tttcaatatg atcggccctt attttgacgg 1517401 gggcagggga cttgacttat tcgcagggag cggaggtctt ggaatcgaag cgctttcacg 1517461 cgggtttgag cattgtatat tcgttgaccg tgattttaaa gcgattcaaa cggtaaaatc 1517521 taatttgaaa acgctggagc ttacaaaaca tgcacaggta taccgcaatg atgcggaacg 1517581 tgctttgcac gctgctgcta aaagagaaac cggctttcgc ggaatttttc tcgatccgcc 1517641 gtataaggaa caaaagctga aagcactttt aactttgatt gacgaatatc aaatgctgga 1517701 agaagacggc tttatcgtcg ctgagcatga cagagaggtc gagcttcccg aaaccgtagg 1517761 agatcttgtg atgacaagaa aagaaaccta tgggttaaca ggtgtagcga tttataaaaa 1517821 gagggggtag tgaggtggcg agtatagctg tctgtcccgg cagttttgat cctgtgacct 1517881 acgggcatct ggacatcatc aaacgcgggg cgcatatttt tgaacaagtg tatgtatgtg 1517941 tgctgaataa ttcttcaaaa aagcctttgt tcagtgtgga agaacggtgt gagcttctga 1518001 gagaagtcac aaaagacatt ccgaacataa cagttgaaac atcgcaaggc ctgttaattg 1518061 attatgcaaa aagaaaaaat gcgaaagcga ttttaagagg cttgagagct gtatctgatt 1518121 ttgaatacga gatgcagggg acatcagtaa accgggtgct tgatgaatct attgagacgt 1518181 tttttatgat gacaaacaat caatattcgt ttctaagttc aagcatcgta aaagaagtgg 1518241 caagatacaa cggctcggta tcagagtttg taccgccgga agtagagttg gcgcttcagc 1518301 aaaaattcag acaaggatga gggttttgac tcatcctttt tttgttccgt ttgtcagtct 1518361 gtaagaaaaa atgataatgt acgtaaacag cgcgcatagt gtgacagcag gtccgatctg 1518421 cacaagcaga ttccagccgt ttataaaggc agttgacatg tcactgctgt taagagattt 1518481 aaatacatac tgatacggat catgccatgc tgtgtaaaga ggtttccata aaagcatgac 1518541 gaagacagcg gcataaacgc cctgcagcaa acgtgcgata aagaatggtt taaatctaat 1518601 gtcggtttcc gataaaatac ctgccacctg agcttgtacg gaaaagccgc taaacccaag 1518661 aataaagctg acgataatgg ctttttgcag aagagaaaca tctgtctcgc tgacaagctt 1518721 gctgcctaat gtaatttcaa acatccctga taaaagcgga atgtccaatt gagtcggaag 1518781 ctgaaacaaa gtcagtgctc cttttgtgaa aacagacaaa acatcagtca gctggaccac 1518841 tgacaacagc cgattgaaga cagaaaataa aataataaag ccgcctacca taagaagcgt 1518901 ttgaacagaa gacgtcacgg cgtcgcctaa aattttacct aagggccgtt tttctgcaag 1518961 tctggcggta tgaagagcgt gtaaagcatc tttgactgaa gggaaaggta tcgttttctt 1519021 tcttctgaga tgctgctctt ccttgcggcc ataggagcgc attgttaaac cgacggcaag 1519081 attccccaaa tagtgtgcag aagctaataa aatgcctagt gatgcgtttt gaaagaaacc 1519141 gacggcaaca gcgccgaaaa taaagagcgg gtttgaagaa ttggtaaacg acgcgagccg 1519201 ttctgcctct actcttgaaa tctgattttc ctgccgcaga cgggcagtga gttttgcgcc 1519261 cgctgggttt cctgatgcca ttcccatagc aagaacgaag ccgccgacac ccggcacgcg 1519321 aaagatcggc cgcataaaag gctcaagcaa aacaccgaca aaccgcacaa tgccaaagcc 1519381 gattaagagt tcggacagaa taaaaaatgg cagcaatgac ggaaacacaa cctcccacca 1519441 catagacagc ccggttttag aggcttcgaa tgaggcctgt ggatgtgaga tgacagtcgc 1519501 tgttaaaaaa agaaaaaacg aggcaatcaa aagtgtatta atcttcgaca agttcattct 1519561 tacctccccg atgctaaaaa tgcccaatga catgtatatc atgataaaat aatgtatgat 1519621 gtaaaacggc caagcagtac ctgtcctctt gattctttgt actaatatac gagcataggg 1519681 gttcagttta gaccatagaa ttcggtatac agggaattca ggcaggaggt taacgctttg 1519741 gccaaaccta aaatcgggtt agcgttagga tcgggagggg ccagagggct tgctcatctc 1519801 ggtgtgcttt ccagtttaca taagcaccaa attgaagtgg atatgattgc aggaagcagc 1519861 atgggcgctt tggtgggcag tttttacgcc gccggacatg acgtggcaac gatgaaaaaa 1519921 gtagccaaag cctttaaacg aaggctttat gctgattata cggtgccgaa actcggtttt 1519981 ttaaaaggtg accgcgtcag acagcttgtg catgcttata cattcggaaa accgattgaa 1520041 gagctccaaa tcccgctggg cattgttgcg tgtgatctac agacgggaga aaagattgtg 1520101 ttccgaaaag gatcagtgtc agatgcagtg agggccagca tcagcatccc gggtatcttt 1520161 attccgcagc ggctggacgg acgccttctt gtagacggcg cggtcgtcga tcgaattccg 1520221 gtttctgttg tgaaagacat gggagctgat attatcatcg cttcggatgt ttccagggtt 1520281 cgaaaaactg aaacagcagt gcatattttt gatgtgatta tgcaaagtat ggatatactg 1520341 caaaatgaat tagtgcggca tcaaacaatt gccgcagata tcatgattcg cccttccctt 1520401 gaaacataca gctcaagctc gtttgccaat attgaagaaa tgatatcggc aggcgaagag 1520461 gcgacaaacc gaatgatcag caagataaga aaagaaatag agaattggga gggctcataa 1520521 tttgctacgt aaaaaacatt ttagctggat gctcgtcatc ctcatactga tcgccgtttt 1520581 atcatttata aaacttccat actatattac aaaaccggga gaagcgacag agcttgcttc 1520641 attgataaaa gtggagggag gctacccgga aaaaggaagt ctgtccttaa tgactgttaa 1520701 agtgggaccg gctaatccat ttacatatgt gtgggcaaag atgcaccctt attatgaaat 1520761 tgttcctgat gagagcatta aggaggaagg cgaatcagat aaggagtata tgaaaagaca 1520821 gctccaaatg atgaaaagct cgcaagaaaa tgcggttata gccgcctatc aaaaggcagg 1520881 aaaaaaagtc agctattcct ttaacggcat atacgcaagc tcagttgtag aaaacatgcc 1520941 ggcaaaaggg aaaatagaag tcggtgataa aatcatcagc gcagacggca aaaactatca 1521001 gtctgctgaa aagctgattg attatatcag cagcaaaaaa gcgggagata aagtcacgtt 1521061 aaagatcgaa agagaagaaa aagaaaagcg tgtcaccctt acgttaaaac aatttcctga 1521121 tgagccggat cgggcaggaa tcggagtttc gctttataca gacagaaacg tgaaggtaga 1521181 gcctgatatt gattttgaaa tcgaaaatat tggcggcccg tcagcagggt taatgatgtc 1521241 ccttgaaatc tataatcagc tgacaaaacc agacgaaaca aaaggctacg atattgcggg 1521301 aacaggtacg attgatgttg acggaaaagt aggcccgatc ggcggcattg atcaaaaagt 1521361 cgtcgccgca gacaaagccg gaaaagacat tttcttcgcg ccaaatcaaa acggcgccag 1521421 caattccgat tataagaacg cagtaaaaac agcaaaagat attgattcaa atatgaagat 1521481 tgtgcctgtt gataccatgc aggatgcgat tgattatttg aataagctga aagcgaaaag 1521541 cacctgattc tcaggtgctt tttctataca tttaaaaagt gttgttcatc ttcgtcatat 1521601 cgaatcggtg catgtccgta ttcctgtagg tcaaactcag ttctcagcgg ctcttctatc 1521661 ggcaggctgt aaatcctgct tgcttttacg tccagatcga gagctggatg ggagaaagag 1521721 gacagtttgc tgacaagcgg aacagacagt gcttttttct tttcggataa ataagcctgt 1521781 ccttttttcg tcatgccgag aagcctgata tacggcgcct tatcgttgtc aagcagcttt 1521841 tgcatatcct gtttttttgt tctggttaaa atgtgtgtat tcatccgctg gagccttgtc 1521901 cacgtatagc gttttgtttt cagcagttcc ataaattcct gataggagct ggattttctg 1521961 atcgaacgaa taattctgtg ctctaaacct tcctccacct cgtatacttg ctgtaattcc 1522021 cgtgccgtta cagttgaaag gctgtatttt aagtaagaaa agtagctttc aggtgtatgc 1522081 cacaatccga aagatttgcg gtaagctgct aattcacgtg cagatgcagc agggagaaaa 1522141 cgaaggcagg cttcgagatt ctggccaatc atcgcttttc taatgcttgt ggcacttgct 1522201 atatggtttt cgccttcagg gagatcggca tcatgatagt ccgaagagat tcgtgccgta 1522261 gtataaggtt tcataggata tcccccggtt agaatcgagg tcacatactg gtatcccaaa 1522321 atgttatttg gttttgacaa gtcaagtgca ctttcagtat gcaaaatgga gctgaaggcg 1522381 atagccgccg ctgctgggta actggccccc tttttaagtt cttctttaat tcggtcattc 1522441 aatatatgtt tatgctcatc aataagctgt gctgtttcta aaaaaggctt gatatcccca 1522501 ttttcactcc cgaaaaacag cgcctcacat tcaagttcgt tcaggatgga aacactgccg 1522561 cgtgcaaaaa tgtctgcttt ttgcacggca taaagataag gcagctcaat gacaagatca 1522621 actccgcttt gcagcgccat ttttgttcgg gcccattttg atacaacagc gggttccccg 1522681 cgctgtaaaa aatgtccgct catgaccgcg acagccgtgt cacatccggt ttgcagcttt 1522741 gctgtttggg catgataaag gtgaccgtta tgaaagggat tatattcaac caccaatccg 1522801 acagctttca tattttttcc gcctttcttg ctatgtttaa aaacgtatgg tacatttgca 1522861 aatgaaaact cttacgcctt atttttgttt taagtgtatg catagcatat tccgctgtca 1522921 acgatacttc aatggcagca ttatgctgta aagaaaaaat attgacaaaa acaatcttaa 1522981 aagctataat catgtttgtt gctttcctga ggtgatacaa atgaaatgga cgatttatca 1523041 gctgcatcaa atgccaaaac aaagttttga gtttgatgaa acagttgagt taaatgagct 1523101 gacaaagctg aattctgaca ttcgccgcat ttctcccgtt cgggtgaagg gcagagcgga 1523161 tatcaaatcc aaacaggttt cgtttgattt tacaatttca ggcgaaatgc ttttgccatg 1523221 ctcaagaaca ctcgttgatg ttccgtatcc atttgaaatt tcaacaaaag aactgtttat 1523281 atttcatcac acggatgata tagaagatga tgacgttcac attgttgagg acgatactat 1523341 cgacataact ccgatcgtga aagaagaaat tcttttagaa atccctatgc aaatcttttg 1523401 tgaatctgaa caagaaaaag gagctgctcc tcaagaagga aaggattggc aagtcatttc 1523461 ggaagaagac aagaagaatc aagttgatcc gagacttgca gcccttgaaa agctcttaaa 1523521 acaagatgat gaatcttaac tctttaagga ggtgggaata atggctgtac cttttagaag 1523581 aacttctaaa atgaagaaaa gattgcgccg tacacatttc aaacttaatg tacctggtat 1523641 gacagaatgt ccgtcatgcg gagagatgaa gttgtctcac cgtgtatgca aagcatgcgg 1523701 atcatacaac ggcaaagaca taaatgtaaa aagtaactaa tgagaaaagc gcagggtgaa 1523761 agccctgcgc tttttctttt tctcttcctg tcagcttgcg gaaaatttgt gagtgcaaat 1523821 agtctatcta atctattacc ggcatatgta tgagataaat aagctgacat ggagggagat 1523881 tgaatttgac cattacaaga caagatgctt ggactcagga tgaggatttg ctgctggcag 1523941 aagtggtgct tcgtcatatt cgagagggag gaacacagct ttcagccttt gaggaggttg 1524001 gaagggcgct gaccagaacc gcggcagcct gtggtttcag gtggaactcg tatgtgagaa 1524061 aacaatacca gtcaggtata gagcttgcaa aaaagcaaag gaaagaactg agaaagcaaa 1524121 tcggcgttca ttcggtcaat atgccgaatt ccatgaagca gactgcctcg gcatcgtcag 1524181 aaggaaaacg agatttgtcc attcaggatg tcattcaatt tctcgaacaa ttcaaagaaa 1524241 caccgtctgc acaagaattt cagcttgaaa gggaaaaatt gaaggagcaa atccaatcgc 1524301 tgcaaaaaga gcttgaggat ttgcggagtg aaaatcagac attgcggaat cagctagaga 1524361 tgacagaaga ggattacaag gcactgatcg atatcatgga tcgggccaga aaaatggttg 1524421 tttcgaagga agacggaaga atgaaaaaag cggctcaaga aacgtaaaga aacgcctgaa 1524481 atgaaccggc cctatagtaa gaataggccg gttgttttga tttctatgca gactctcccg 1524541 gtgtcatttc gcgatccata tcaggatgcc agatgagcgg gttttcccct ttgtcccgcg 1524601 ccatatcata cttaacagtt ttaaagttca ttttgttcca aaattccgct gatttcattc 1524661 tcggatttgt ccggatcggc attttgaatg attttgcaaa ttcaaccaag gctctcccgt 1524721 atcccctgtt ctggtagccc ggaagaacct caagcttcca cagctccaaa taatcctggc 1524781 ggttgtcaaa atagggattc gatttgccgt taacttgata cagactcatt cgtgctacaa 1524841 gtttatcgcc aaaataaatc ccgtaaaaag gcgaggtgct gtcattttca ataatattat 1524901 cctgaagttc ttcaagcatt gaaagctcct gaatgccgta ttctttgaat ttcttgaatt 1524961 cttccagcgt tttatagttg ataagcagac gttctacctt tgtcaaacaa atctccccct 1525021 ttgttgtttc tacatatatt gtaaacgctt tatttaaaaa atccaaatat ttaaacttta 1525081 attttaagca catgggatct ttgagaagta atttcttctt acttctgcta tgataatacg 1525141 taaatgctaa attgggtgtg acatcatgaa aattggaatt atcggcggag gctccgttgg 1525201 tcttttatgc gcctattatt tgtcacttta tcacgacgtg actgttgtga cgaggcggca 1525261 agaacaggct gcggccattc agtctgaagg aatccggctt tataaaggcg gggaggaatt 1525321 cagggctgat tgcagtgcgg acacgagtat caattcggac tttgacctgc ttgtcgtgac 1525381 agtgaagcag catcagcttc aatctgtttt ttcgtcgctt gaacgaatcg ggaagacgaa 1525441 tatattattt ttgcaaaacg gcatggggca tatccacgac ctaaaagact ggcacgttgg 1525501 ccattccatt tatgttggaa tcgttgagca cggagctgta agaaaatcgg atacagctgt 1525561 tgatcataca ggcctaggtg cgataaaatg gagcgcgttc gacgatgctg aaccagaccg 1525621 gctgaacatc ttgtttcagc ataaccattc ggattttccg atttattatg agacggattg 1525681 gtaccgtctg ctgacgggca agctgattgt aaatgcgtgt attaatcctt taactgcgtt 1525741 attgcaagtg aaaaatggag aactgctgac aacgccagct tatctggctt ttatgaagct 1525801 ggtatttcag gaggcatgcc gcattttaaa acttgaaaat gaagaaaagg cttgggagcg 1525861 ggttcaggcc gtttgtgggc aaacgaaaga gaatcgttca tcaatgctgg ttgacgtcat 1525921 tggaggccgg cagacggaag ctgacgccat tatcggatac ttattgaagg aagcaagtct 1525981 tcaaggtctt gatgccgtcc acctagagtt tttatatggc agcatcaaag cattggagcg 1526041 aaatacaaac aaagtctttt gagctttttc ggtaacatgc tatactcatt tcggatcact 1526101 aactatttat tggagaaagg aagttctaga agatgcagct aactgaactt tccatcaaaa 1526161 atcagaatgt gtttgtacag cactatatag atggcaaaga agaaatgtct tctttttttg 1526221 attacagtat tcatcataag gacatgtggc gcgaaagact ggaagactta tcttcccggt 1526281 ttttcgcaag agaggaattg gcggcgtact taacctctta ccataataaa ttcggttcaa 1526341 gtgcgatgca gtctgctatt gagaagctga aggacccgtc aagtgccgct gtagtcggcg 1526401 gacagcaggc aggactttta acaggaccgc tttacaccat acataaaatc atttcaatca 1526461 ttgttttagc aaagcaacaa gaaaaggaac tgcaagtgcc tgtcatacca atcttctggg 1526521 tggctggaga agaccacgat ttggatgaga ttaattttgt tcacacatct gaagagaatg 1526581 ggcctgtgaa aaaaaagctg cctcagtctt attggaagaa atcatcagca gcgagtacat 1526641 cgcttgatca ggaaaagtgt gccgcgtgga tagatgatgt ttttgccgct tttgaagaaa 1526701 cagaccatac gaatacactt ctcgacaatg tgaaacgatg tttaagggaa tctgttacgt 1526761 ttactgactt ctttgaactg ctgatcgcgg atttgttcca agaagagggc ttagttttat 1526821 taaattctgg ggatccgggg attaaaaagc tggaaacggc catgttccaa aagattcttc 1526881 gagaaaatga tgaactcgcc cgggctgtat cagatcagca ggccttcatg cgtcaagcag 1526941 gctacaaacc gattatcgag tccggaaaag agcaggcgaa tctgttttat gaatacgaag 1527001 atgagcgttt tttaattgaa aaagataacg gccgatttgt catcaaagag cttgatctag 1527061 gatggacgag ggatgaactt catacacata tggaagaaca tccagagcgt ttcagcaaca 1527121 atgttgtaac gagaccgtta atgcaggaat ttctcattcc gactttagca tttattgcag 1527181 ggcctgggga aatcaattat tggggcgagc tcaaacaggc atttgcggtg atgggcttca 1527241 aaatgcctcc tgtcatgcca aggctgaaca ttacgatact tgagcggcat attgagaaaa 1527301 aactggctga acggaatatc tcattacaag acgcgattga gcgcggaacg gagaatcaaa 1527361 gagagacata cttcgagcgc cagattccgg aagagtttac ggcggtgatg gatcaggcga 1527421 aaagccaaat tgaagcgatt cacaaaacgg tccggcagga ggcgttaaag gttgatcaaa 1527481 gcttggaacc tttacttctg aaaaatgccg cttttattca ggatcagctt caattcttag 1527541 agcgcacggt gatgaagcga attgaagaaa aagaaggcta cgtcttgaag gattatgaaa 1527601 gaattcaaaa tagcattaag ccgcttcttg cgccgcaaga acggatttgg aatatcatgt 1527661 attatttgaa caggtacggt ccaaaattct tcacgacatt caagaatctg ccattttctt 1527721 ttcaaaatca acatcaagtt gtcaaacttt gaaataaagt tttaaagaac cctgactagt 1527781 tcagggtttt tttttatggg taaacagtgt aaaatgaagt tgtggagcga agtggtgaat 1527841 agtggtgagt taaggagaga aagtggggca agagatcatg tttatgggtg aatatcagca 1527901 taccatcgat gcgaaaggcc gcatgatcgt acccgctaaa ttcagagaag gcctaggtga 1527961 gcaatttgtg ctgactagag gacttgacca atgtctcttc ggctacccta tgcacgaatg 1528021 gaaacaaatt gaagaaaaac taaaagctct tcctctcaca aagaaagatg cccgcgcgtt 1528081 tacccgtttc ttcttttcag gggcgactga atgcgaactg gataagcaag gcagggtaaa 1528141 tatcgcatca tctctattga attacgccaa actggaaaaa gaatgtgttg ttatcggggt 1528201 ttctaatcga attgaattgt ggagtaaagt aatttgggaa caatacacag aagagcaaga 1528261 agattcattt gctgaaattg ctgaaaacat gattgggttt gatatataat gattcttcgt 1528321 gtataacact ctaaaaacaa tttcaattca tcctgataaa aggtgggacc aacacaatat 1528381 gtttcaacac aagacagtac ttcttcgtga aaccgtagac ggacttaata ttaaaccaga 1528441 cggtacatat gtagactgca cactcggcgg agctgggcat agtacatact tattgcagca 1528501 gttatccgag aaggggcgtt taatcgcttt tgaccaagat gatacggcat tacagcatgc 1528561 taaagaagtg ttgtccgatt ataaaggaca gctcattctg attaaaagca atttcaggta 1528621 tttaaaagaa tatttgaatg aacaaggcgt tacagaagta gacggcattt tatttgattt 1528681 aggggtgtcc tctccgcagc tggatacacc ggagcgcgga ttcagttacc atcatgacgc 1528741 accgttggac atgaggatgg accagtcggc tacgctttcg gcgaaagaag tcgttaatga 1528801 gtggcgctat gaggatctcg tccgtatttt ctttaaatac ggagaagaga agttcagtaa 1528861 acagatcgcc agaaaaattg aggaggcaag aatgaagtct cctattcaaa ctacgggcca 1528921 actggtcgat ctaataaaag acgcgattcc cgctccagcg agaaggagcg ggggacatcc 1528981 cgctaaacgc gtgtttcagg caatcagaat tgccgtaaac gatgaactta gggtgtttga 1529041 agaagctttg gagcaggcaa ttgaggttct gaagccaggg ggcagggtat cggtcattac 1529101 cttccactcg ctagaagaca gaatttgcaa aaccactttt aaagaaaagt cgtcgcttcc 1529161 ggaacttcct ccgggacttc ctgttatacc ggaagagttt gaaccggagc tgaagctcat 1529221 cacacgaaaa ccgattacgg catctcaaga agagcttgaa gagaacaacc gggctcgttc 1529281 tgccaagctt cggattgctg aaaaaagaaa ataacgaaac gcgaacgcaa aattaaaagg 1529341 aggtcatcag cctatgagca atttagctta ccaaccagag aaacagcagc ggcatgcgat 1529401 cagtcctgag aaaaaagtga ttgtcaagaa aagggcttcc attactctcg gagaaaaagt 1529461 gcttcttgtc ctctttgctg cggcggtgct cagcgtatcg cttttgatcg tatcgaaggc 1529521 gtatgcggca tatcaaacca atattgaggt gcaaaagctt gaggagcaaa tttcatccga 1529581 aaataagcaa attggtgacc tcgaaaaaag cgttgctgat ttaagcaaac cgcagcgcat 1529641 tatggacatt gcgaaaaaga acggcttgaa tttaaaagat aaaaaagtga aaaacataca 1529701 ggaatgattc aaatgccaaa aaagaataaa tttatgaata gaggagcagc gattctaagt 1529761 atttgtttcg ctctcttttt ctttgtcatc ctggggagaa tggcatatat tcaaataacc 1529821 ggaaaagcga acggcgaagt gcttgcgaca aaagcgacag agcagcatga aaagaaacgg 1529881 accatcgaag cgagccgcgg ctcgatttta gaccgaaaag gaaaagtcat tgcagaggac 1529941 acagcgacgt ataaactgat tgcgattctc gataaaaaaa tgaccactga tgtcaagcat 1530001 cctcagcatg ttgtaaacaa agaaaaaacg gcggaagcat tgtctaaagt gataaacttg 1530061 gacaaggccg acatccttga tatcttaaat aaagatgcaa aacaagtcga gtttggctca 1530121 gctggccggg atattacgta ttcacaaaag caaaaaatcg aaaaaatgaa actcccgggc 1530181 atttcatttt tacgggatac aaaacgctac tatccaaacg gagtatttgc atctaatcta 1530241 atcggctatg ccgaggttga tgaagaaaca aatgaaattt ccggcgcgat gggattagaa 1530301 aaagtgctgg ataagtattt gaaggagcgg gacggatatg tgacatatga aagcgacaaa 1530361 tccggctggg agctcccgaa cagcaaaaat aaaattacag cgccaaaaaa tggtgacaat 1530421 gtatatttaa ccattgacca gaaaattcaa acctttttgg aagacagcat gacaaaagtg 1530481 gcgcaaaagt ataatccgaa aaaaatcatg gccgcagtcg ttgatccgaa aacgggcaaa 1530541 gtccttgcca tgggacagcg cccaagcttt gatccgaaca agcgcgatgt gacaaactac 1530601 tataatgatt tgatttcata tgcgtatgaa cccgggtcca cgatgaagat ctttacactc 1530661 gctgctgcga tgcaggaaaa cgtgtttaat gcgaacgaaa aatataaatc agggacattt 1530721 gaagttggcg gagcacctgt taaggatcac aataacggtg taggctgggg tccgacaaca 1530781 tatcatgacg gcgtcctaag gtcgtcgaat gtcgcttttg cgaaactggc gaaagaaaag 1530841 ctgggatatg accgcctcaa tcaatatttg cacaaattca atttttacca gaaaacaggt 1530901 attgatttgc caggagaagt ctccagcaaa atcaacttta aatatgaatt tgataaggcg 1530961 tcaactgcat atggccaagc gtctgcggtc acaccaattc agcagattca ggccgcaacg 1531021 gcaattgcaa atgacggtaa aatgatgaaa ccttatgtca ttgaccatat cgttgaccct 1531081 gataaagata aaactattta tcaaaataag ccggaatcag ccggaactcc aatttctgca 1531141 agtactgcga aaaaggtgcg ggatatatta ggagaagtcg ttacatcgaa gatcggaaca 1531201 gggcaagctt ataaaatcga aggttttgat gttgccggga aaacaggtac tgcgcaaata 1531261 gccggtaaag gcggatattt agacggcaca gataactata tcttttcgtt tatgggtatg 1531321 gcgccaaaag atgatcctga gcttttaatt tatgttgctg tacagcagcc gcaactaaaa 1531381 gcaggacaaa gcagttcaga tccagtatca gaaatcttca atccaacaat gaaaaatagc 1531441 ctgcactacc taaacatcga accaactgaa aaatctgact cagataagga agaaacaaaa 1531501 gcgcagacaa tgcctgattt aacagatcaa acggtagctg ctgctcaaaa gaaagcaaaa 1531561 gaggagaatc tcacaccaat tgtcatcggc agtgatgtcg ctgtaaaaga acagtatccg 1531621 aaagcggatg aggaagttct caccaatcaa aaggtcttcc tgaaaacggg cggcaaaatc 1531681 aaaatgcctg atatgacagg ctggtcgaga agagaggttc tgcagtacgg cgagctcgcg 1531741 ggaattcata ttgaagtaag cggacaaggc tacgctgtca gccaaagtgt taagaaagac 1531801 aaagaaatca aagacaaaac cgtaatcaag gttaagttta aaaatcctga ttaaaaagaa 1531861 agccgtcgtt atgcaggctt tcttttttta tgccttcaga ggagcatcgt tctacctgtc 1531921 caaattcagg cataaaatga aacaagccta aataaggagt gaacggtctc ttgcgcgtct 1531981 cgaatgtaac ggttagaaaa cgtttattat ttgttttgct ttttggcgtg atcgtgtttc 1532041 tgatcattga tacaaggctg gggtatgttc agtttgtgat gggcgaaaaa ctgacttcgc 1532101 tagcgaaaga ttcctggagc cggaacttgc cgtttgagcc ggagagaggc gagattctgg 1532161 atcggaatgg tgtgaagctc gcaacaaata aaagtgcgcc gaccgtattc gtcgtgccgc 1532221 gccaagttca gaatccgatg aaaacgagca agcagcttgc ggcggtgctc aatatgtcag 1532281 aagaaaaagt atataaacat gtgacaaaaa aagcgtcaat cgaaaagatc actcctgaag 1532341 ggagaaaaat ttcaaatgag aaggcgaaag aaatcaaagc gcttgattta aaaggtgtgt 1532401 atgttgcgga ggacagtatc cgtcattacc cgttcggcag ctttttatct catgtgcttg 1532461 gatttgcagg aattgacaac caagggctcc ttggacttga agcctattac gacgatgatt 1532521 taaaagggga aaaaggttct gttaagtttt atacagatgc caaggggaag aagatgcctg 1532581 atgaagcgga tgactatacg ccgcctaagg atgggcttga tatgaagctg acagttgatt 1532641 caaaggttca gacgataatg gaaagagagc ttgataacgc tgaggccaaa tatcatccgg 1532701 acggcatgat tgccgtagcc atgaatccga aaaacggaga aattttgggg atgtctagca 1532761 ggcctgactt cgaccctgct gattaccaat ctgttgatcc gtccgtctac aatcgaaatc 1532821 tgccagtatg gagcacgtat gaaccgggat ctacctttaa aattattaca cttgcagcag 1532881 cccttgaaga gcaaaaagta aatttgaaac gggatcaatt ttatgataaa gggcatgctg 1532941 aagtggacgg agcgagactg cggtgctgga aaagaggcgg gcacgggctg cagacgtatc 1533001 tggaagttgt gcagaactcc tgcaacccgg ggtttgttga attaggcgag cgcttaggaa 1533061 aggaaaagct tttcaaatat atcaaagact ttggttttgg acaaaaaacg gggattgatc 1533121 tccaaggcga gggaacaggc atcttattcc cgcttgagag agtgggcccg gtggagcaag 1533181 caactacggc tttcggacag ggagtatccg tcacgccgat tcagcaggtt gcagcagtat 1533241 ccgccgctgt aaacggagga acgctctata caccttatat tgcaaaggaa tggatcgatc 1533301 ctgttacgaa gaaaacggtc aaaaaacaat caccaatcgc aaagaaacaa gtcatttctg 1533361 aggaaacatc caaacaaatc cgctatgctc tagaaagcgt cgtcgcagaa ggaaccggcc 1533421 gcaatgcatt tgtagaagga tatcgtgtcg gaggaaaaac gggaactgca caaaaggtta 1533481 aagatggaaa atatcttgaa aacaaccata ttgtatcatt tatcggtttc gcgccagcag 1533541 atgatccgag tctagtcgtc tacgttgcgg tggataaccc gaaaggcacg attcagtttg 1533601 gcggaacggt ggcagcgcct attgtcggaa atattatgag agacagtctg ccggaacttg 1533661 gtgtgaagcc ccggaaaaat caaatcgaga aaaaatacca atggaacgac acaaaaacaa 1533721 tagaagttcc gaatgttgta gggatgtctg tctcagatct tgagtcacta ttggtgaatc 1533781 tcaatgtgga tgcttccggg aaagggagca aaatcgttaa acaatcgcca gctgccggaa 1533841 cgaaagtaaa agaaggctca aagatacgcg tgtatttgac tgaagaagat gaaaaggagg 1533901 cagccgattg attcgggctg cctattcttt tattgcagaa aaaatgctga tatctttcaa 1533961 gattagctgg atgtatcctt ttatttacgc taaaatatga actgtatgct taaaatcatt 1534021 accacatcat ttgatgtgac ttcaatgata aaaagaacga attagaatgt tgagaggttt 1534081 gatacgatga aacttacaaa gctgcttaca tacttaacaa ccgaaccttc tgtaaacgac 1534141 tcacaagacc ctgaaataac ttcaattgag atggactcca gggaagtaaa gaaagggagt 1534201 ctttttgtat gtgtaaaagg gtatacggtg gatggccacg attttgcgca aaaagcagta 1534261 gaaaacggtg cagcggctat tgtggcagaa agagaggtcg atgtgaatgt tcctgttatt 1534321 attgtccggc agtcacttcg cgcgctcagc gttttgtctg atgcgtttta cggacagccg 1534381 acgaagaagc ttcagctgat tgggataaca gggacaaacg gcaaaacatc aacgacccac 1534441 atggtcgatg agattctgaa aaaagcggga aaacgcacag gcttgatcgg tacaatgtac 1534501 atgaaaatcg gagacgaaac acttcctgtt aaaaacacga ctccggaaag cgtcacgctg 1534561 cagaaaacgt ttaagaaaat gaatgacaag cacgttgaca ctgcaatcat ggaggtttct 1534621 tcccacgctt tgtctttagg acgcgtccat ggctgtgatt atgatattgc cgtgtttacg 1534681 aatttaacac aggaccatct ggactatcat aaaacgatgg atgagtaccg gcatgcaaaa 1534741 agcttgctct tttcccaact tggcggggct ttcaaccatg aacatccaaa gcgtgccgtc 1534801 ctgaatgctg acgatgaggc gagcgcttat tttgaaaagg taacagctgc gcatatctct 1534861 acatacggaa ttaaaaacga tgctgatgtg atggcgaaga acatcagtat cactgcacag 1534921 ggcacaagct ttgatctcgt gacaaacaaa ggcacgaagc acatcacgat gtctctcgtc 1534981 ggacaattta atgtgtataa cgtgctggcc gctgttgcga catgtattgc agcaggcata 1535041 ccgtttgaaa tcatcactga ggctgttgaa gaattgcatg gtgtaagagg ccgttttgaa 1535101 ttggtcaatc agcagcagga gtttcctgtc attgtagact acgcgcacac accggacagc 1535161 cttgaaaatg tgctggagac atgcagagac atgacggaag gaaagctatt tgtcgttgtc 1535221 ggctgcggag gagacagaga taagacgaag cgcccgaaaa tggctaaaat tgctgtggag 1535281 ctggctgacg agccgatttt cacgtcagat aacccgagaa gcgaagatcc tcgcgcgatt 1535341 ttaagagata tggaagccgg agtagagaac gcatactatc acagtattgc aaaccgcgag 1535401 caggcgatct ttttcgcaat tgccaatgcc aaaaaaggcg acgttgtcct cattgccgga 1535461 aaaggacatg aaacctatca gcagatcgga aatgaaactt tcgattttga tgatgctgaa 1535521 gtagcggcga gagccattgt tgaactcaat aagaataaga cgaattcata ggaaagagat 1535581 gttactgaat aatggagctt gaaaagattt ttcatatgga aaaaaatcat gaatatgata 1535641 actacgtatg tcgtttgaaa gaaacaggag gagaaaagga caatgcttga gcaagtcatt 1535701 ctgtttacaa ttttaatggg gtttttaatt agtgttctgc tctctccgat tcttattccg 1535761 tttttaagaa gattaaaatt cggccagagt attagagaag aaggaccgaa atcacatcag 1535821 aaaaaatcag ggacaccgac aatgggcggg gtcatgatca tactttctat catagtgaca 1535881 acaattgtta tgacacagaa gttttcagaa ataagccccg aaatggtgct gcttctgttt 1535941 gttacgctag gctacggttt gcttggcttt ttagatgatt acatcaaggt tgtcatgaag 1536001 cgcaatcttg gattgacatc aaagcaaaag ctgatcggac aaattattat tgcggttgta 1536061 ttttacgccg tgtatcatta ctacaatttt gcgacggata ttcgcattcc tggaactgac 1536121 ttatcatttg atcttggctg ggcttacttt atccttgtgc tctttatgct agtcggcgga 1536181 tcaaacgcag ttaacctgac tgacggcctt gacgggttat tatccggtac tgcggcgatt 1536241 gcctttggcg cctttgccat tctggcatgg aatcagtctc aatatgacgt agcgattttc 1536301 tcagttgccg ttgtcggtgc agttctgggc ttccttgtat ttaatgctca tccggccaaa 1536361 gtttttatgg gagatacggg atcgcttgca ttgggaggag ccatcgttac cattgccatt 1536421 ttaacgaaat tagagatcct gctggttatc atcggcggtg tattcgttat cgagacatta 1536481 tccgttattt tgcaggtcat cagctttaaa acgacaggta aacgaatctt taaaatgagt 1536541 ccgcttcatc accattatga gcttgtcggc tggtctgaat ggagagtagt cgtgacgttt 1536601 tgggctgcgg gacttttgct tgccgtttta ggaatttaca tcgaggtgtg gttataagtg 1536661 gaaaatgatc aatttttaca gaaacagcat tttttaatcc ttgggcttgc gaaaagcgga 1536721 tatgcggcgg cctccattct tcatgaaaaa ggcatttatg ttgcagtcaa tgatcaaaag 1536781 ccttttgaag aaaatgaacc ggcacaaaag ctttctgaaa aaggaatcga agttgtttgc 1536841 ggagagcatc cagtttctct gttcgatcag catcaaatca cgattctgat caaaaacccg 1536901 ggaattcctt atgaaaatat catggttcag gaagcagaga aacgaggtat tccggtttgg 1536961 acggaaattg agctcgctta ctacctgacc agcgccaagt ttatcgggat taccggatcg 1537021 aacggtaaaa cgaccacgac aacgctaatt tacgaaatgc tcaaggctga ctcgcaaaaa 1537081 gcactgattg ccggaaacat cggcacagtc gcaagtgagg ttgcctatca tgctgatgga 1537141 gatgaatgga tcgttaccga actgtcttcg tttcagctga tgggaacaca cgctttcaga 1537201 ccggaaatca gcctgatttt aaatgtattt gacgcccatc tggattatca ccatacgcgc 1537261 gaaaactatg aaaaagcgaa acagaaagtg taccttcatc agactgcttc agataaagct 1537321 attgtcaacc aggatgatga aaccgtcgtg cgtcttgctg aagccggaaa agccgaaatc 1537381 gtcccatttt cagtcagcaa aacgcttgaa cagggcgcat atgtaaaaga cagtatgatt 1537441 atgtttaacg gcgaagccat tcttcctctg gaagaggttg tactgcccgg tgctcataac 1537501 ctggagaaca ttttagcagc tattgcagtt gtgaaaacgg caggagcatc caatgaggcg 1537561 gttaaaaagg tgctgacaag ctttactggt gtgaagcacc gcctccaata tgtcacaact 1537621 gtgaatggcc gcaaatttta taacgacagt aaagcaacaa acattctggc gacaagcaag 1537681 gcgctttcag cttttgataa gccggtcatt ctgcttgcgg gcggactgga tcgcggaaat 1537741 ggttttgatg acttgaaacc ttatatgaag catgtcaaag cagtgcttac atttggccag 1537801 acggcgccaa aactcgagaa actcggcaat gaactgggaa tacaacatgt caaacgtgtc 1537861 gataatgttg aacaagcagt atctgcggcg tttgcgctct caaatgaagg agatgtcatc 1537921 ctgctgtcac ccgcgtgtgc gagctgggat caattcaaaa catttgaaga acgcggtgac 1537981 atgtttatag atgccgtgca tatgcttaag taagggcttg tcttgaagta aatcggcagc 1538041 cctaatgact ttaagcttgg ggtgtcgatt gctttgacta ctaaaaaaac atcgcctgat 1538101 ttgttattgg tcatcattac gttattatta ttaacaatcg gattaattat ggtgtacagt 1538161 gcgagtgcgg tatgggcgga ttataaattt gacgactcat tctttttcgc gaaacggcag 1538221 cttttgtttg cgggaatcgg cgtcattgct atgtttttta tcatgaatgt tgattattgg 1538281 acttggagga catggtccaa attgctgatg gttatctgct ttttccttct ggtgcttgtt 1538341 ttgataccgg gcgtcggaat ggtgcggaac ggttcaagaa gctggatcgg agtcggagca 1538401 ttcagcatac agccttcaga gtttatgaag cttgcgatga ttgcattcct tgctaaattt 1538461 ctctctgaaa aacaaaaaaa catcacatcg ttcagacggg ggttcgtccc tgcacttggc 1538521 atcgtgtttt cagcattttt gattatcatg tgccagcctg acctcggaac ggggacagtt 1538581 atggtcggaa cttgtattgt catgattttt gtagccggcg cacggatcgc ccatttcgtc 1538641 tttctcgggc tgatcggcct cagcggattt gtcgggctcg tactatcggc tccatatcgg 1538701 ataaagcgga ttacctcata cttaaatcca tgggaagacc cgctcggaag cggatttcag 1538761 atcattcaat cgctttatgc agtggggccc ggcgggttgt tcggaatggg gctcggacaa 1538821 agcagacaga agttctttta tctgcctgag ccgcaaacag actttatttt cgccatcttg 1538881 tcagaggagc tgggctttat cgggggaaca cttattttgc tcctcttcag cgtcctgctg 1538941 tggagaggaa tcagaattgc gcttggtgcg cctgatctgt acggaagctt tgtcgcagtc 1539001 ggcattattt caatgattgc cattcaagtc atgataaata tcggcgtagt cacgggcctg 1539061 attcctgtaa caggcatcac gctcccgttt ctgagctacg gaggctcttc attgactcta 1539121 atgctgatgg cagttggtgt gctgctgaat gtaagccgct actcgaggta ttaacgaatg 1539181 tatttccaag cctcctgtct aacatgaagc ttggaaacaa ttgatgcgat aaccctgtcc 1539241 aacaaaacag ggttatcgtt atgttataga gaaacttaga ctgggggaaa aaagaaatgc 1539301 gaattgcaat aagcggaggc ggtacagggg gacatattta tcctgctctt gcttttatta 1539361 aagaagtgca aagacgtcat cctaatgtgg aatttttata tatcggaaca gaaaacgggc 1539421 tggagaaaaa aattgttgag cgggagaata taccgtttcg ttcaattgaa attacaggat 1539481 ttaaaagaaa attgtcattt gaaaatgtca agactgtgat gcgttttctg aagggcgtca 1539541 aaaagagtaa atcgtattta gcggaattta agcccgatgc cgtaattgga acgggcggtt 1539601 atgtatgtgg gccggttgtc tatgccgctg cgaaaatggg aattccgact attgtccacg 1539661 aacaaaacag cctgccgggc atcacgaata agtttctttc aaaatatgtt aataaagtag 1539721 cgatttgttt tgaagaagcg aaatcacatt ttcctagcga gaaagttgta tttacgggaa 1539781 acccgagagc ctctgaagtc gtctcaataa agacgggacg atcattggct gaatttgggc 1539841 tttctgaaga caaaaaaacg gtcttaattt tcggcggaag ccgaggcgct gcaccgatta 1539901 accgcgctgt cattgacatg caggatgtgc tgaaaacaag agactatcaa gtgctgtata 1539961 tcaccggtga agttcactat gaaaaagtaa tgaatgagct gaaaagcaag ggtgccgctg 1540021 ataatatggt cacaaagccg tttcttcatc aaatgcctga gtatttaaag gccattgatg 1540081 tcattgtggc cagagccggt gcgacaacga ttgccgaaat tactgctctc ggaatcccaa 1540141 gtgttctgat cccaagtcca tatgtgacag cgaatcacca ggaggtcaat gcgaggtctc 1540201 ttggccagca tgatgcggcg attgtactga aagaaacaga gctcagcggg gagaagctga 1540261 ttgaagcgct agaccggatt gtactgaatg agcaaacgtt aaaggaaatg agcgaacgaa 1540321 caaagtcact cggtgttcct gacgcggctg cccgtttata cagcgtactc gaggaattaa 1540381 aaaaatagta gaaaagcaaa tggaatgcgg aggtttacga tggagaaagt gatacaggaa 1540441 ttaaaagaac gagaagtcgg caaggttctt gcaaatgaac cgctcgcgaa tcatacaacg 1540501 atgaaaatcg gcggacctgc ggatgtattg gtcattccaa gcagtgtgga tgctgttaaa 1540561 gacatcatgg acgtgattaa aaaatatgat gtgaagtgga cagtcatcgg ccgcggatca 1540621 aatcttcttg ttttagatga aggaattaga ggcgtagtga tcaagctggg ggcgggtctt 1540681 gaccatttgg agcttgaagg ggaacaagta acagtcggag gcggttattc ggtggtccgc 1540741 cttgctacat cattgagcaa aaaaggcctg tccggtttgg aatttgctgc cggcattcca 1540801 ggatcagtcg gcggagcggt ttatatgaat gccggcgctc acggttctga tatgagcgag 1540861 atcctcgtca aagcgcatat tttatttgaa gacggaacga ttgagtggct gacaaatgag 1540921 cagatggatt tcagctacag gacatctgta ctgcaaaaga aacgcccggg cgtttgcctt 1540981 gaagctgttt tgcagcttga gcagaaggat aaggaatcaa tcgttcagca aatgcaaagc 1541041 aataaagact atagaaaaaa tacacagccg tattcaagcc cttgtgcggg aagcatattc 1541101 agaaatccgc ttccgaatca tgccgggaac cttgtagaaa aagcaggctt gaaaggatat 1541161 caaatcggcg gtgcaaagat atcggagatg cacggaaact tcatcgtcaa tgcgggggga 1541221 gcatcagcaa aagatgtgct tgatctcatt gaccatgtga aaaagacaat ccgtgaaaaa 1541281 tacgagattg atatgcacac agaggttgaa atcatcggcg gaaatcgctg attcaagttc 1541341 tgactgaagc tgttcatatg atatactgta agcaaacgac aaacggcatc atagtatgcc 1541401 gtttgttttg gaatagacag acttttaaca gctgtttcat ttgaatgagg tgaacaggca 1541461 atgaacccgg gtcaagaccg agaaaaaatc gttaacattg aagagcggat ccctaaaatt 1541521 aaagagcaga ggaaacaaaa ggcaaaccgc cgtctcattt catttattat gctctttttt 1541581 attatggtgc tgatcattgt gtacctgcaa acaccaatca gtaaagtatc aacaatctct 1541641 gttacaggga atgaaaatgt atcaaaaaag gaaattatcg acctttccga tattaacagc 1541701 ggagatactg agttttggag tttggacaag caaaaaacag aaaagaagat tcagcaaaat 1541761 aaattagtga aaaaagcgga gatcagcaaa tcgcttccta ataaaatcaa cattgcaatc 1541821 gaagaatata aagcgattgc ttatttagaa aaagacgatg tgtactatga agtgcttgaa 1541881 aacggctcag ttctgccaaa cgaagtaacg ccggatgatg ccggaccgat tttagtgaat 1541941 tggacaaacg cgaagaagcg gtctcaaatg gccaagcagc tcgatgcgtt gtcaaattcg 1542001 ttaaaacagt cgatttcaga aatttattat acgcctgtaa aaatggatga aaaccgtatt 1542061 aagttgtaca tgaacgacgg ttatgttgtt acggcatcta ttaaaacgtt tgcagaccga 1542121 atgaagacgt atccttctat catctcacag ctaagcagca ataaaaaagg aatcattcat 1542181 ttagaagttg ccacctattt tgaagagttt gggaaaaacg ataaagctgc taaaaaggaa 1542241 gatgaaaatt gaggggcaaa tcagcagtcc ttctttcctt gattatgctt atcgcaggtt 1542301 ttttgatttc attttctttt caaatgacaa aagaaaacaa caaaagcgcg gctgagacgg 1542361 aagagtggaa aaaagaatat gcgctgagag atgaactgct gaaacaagag aaagaaaata 1542421 agaagtttga aaaagaatta tatcaaaagc aaaacaaagt ccgccaggcg gaaaataagc 1542481 tgaagaaaga gaagtcggaa tactataatg tcctcgaaga tacagaaaaa tacaggatgt 1542541 atattgggga agtcggtgtg cagggagaag gcgttgaggt gacattggaa gatgcgtcat 1542601 acataccgga aggggagaat gtgaatagtt acatcgttca cgaaagccat atcttccaag 1542661 tagtaaacga actgtatatc tcaggagcgg cagctgtcgc cgttaatgga cagcgtttga 1542721 cgcatgattc gtatatcaaa tgcaatggtc ctgtggtaac ggtagacggg gtgcagcatc 1542781 ccgctccgtt tacggtatcc gctattggag atccagatgt cctgctgccc tcgttaaata 1542841 tcgctggagg cctaattgat cagctgtcaa tggatcatat ttctgtgtcg gcagaaaaag 1542901 agaaaaacgt acaaatgaaa ccgattctga aaacgaagga atgactgaaa aagcgggtga 1542961 aatagattga aaataaagcg ttccttcata agcatcagtg ttcttatggt catcttcggc 1543021 ctgatgatat ctgttcagtt taattcgtta aagcacccca aagtccggga tacaagagat 1543081 atgtgggata ttagggaaga gctgacatca gagcagaaga agcaggaaaa gctgctggct 1543141 gaaataaaca aatatgacaa attgctgaat agctattcgc aaacgaaaga aatgacaaaa 1543201 gaaaccgcgc taaataatac cttgcaatcc ttaaaaaaaa cagccggcat gaccgatata 1543261 acaggtagcg gaattgtcat tacgatttcc ccgctttttt ctgaaagctt aacaggagag 1543321 ccgatcgaaa atccgcctcc ggatttgctg aaaaagctga taaatgaact caactcctac 1543381 ggtgcagagc atatctcgat taatgagcga agagttgtga atcatacagt catcagagat 1543441 ataaacggca ctacaaaaat agacggatac gcccttgacg attatccttt aacagtaaaa 1543501 gtgcttgcca aagatccgga catgttacac agcagagtga aggggtcagg ccttgaggat 1543561 ctttttgcat ctgaaaattt agcattaaaa gccggtaaat ctgaaagcaa actaacatta 1543621 aaagcatatg acagaccact ggacgtacaa cagctgaaac tgcttaaaga ctgaaaagga 1543681 ggagaattgt catgtggctg cccgtgttgg gactggtgct cggaatagcg attggactaa 1543741 tgacaaactt aacgataccg agtgaatact caaactattt atcgcttgcg gtgcttgccg 1543801 cacttgatac attaatcggc ggaatcaggg cgcatttaca aggtacatat gatgaaatgg 1543861 tatttgtttc cggtttcttt tttaatatta tattggcaat aagtttagct tttctgggag 1543921 tccatcttgg tgtagacttg tatttagcag gtatattcgc atttggagtc agattatttc 1543981 agaatatagc cgttatcaga agaaatctac taacaaagtg gactctttct aaaaaaaata 1544041 aaaaaaatgt gatataaaag aggatataca taggatataa cgaatatttt caataaacat 1544101 aaaatgtgaa aagcacataa aaatattctg ttgttatttt ttgttacaca cttgtaaagc 1544161 cacattcatt gtattgttgt tccgcaaata atagaataga aatgatcgaa atgtgaggag 1544221 gtgccataga atgaacaaca atgaacttta cgtcagtctt gacatcggta cgtccaatac 1544281 aaaagtgatc gtcggagaaa tgacagatga ttcccttaat attatcggtg tgggaaatgt 1544341 accgtctgaa gggttgaaaa aaggctcaat cgttgatata gatgagaccg ttcattctat 1544401 aagaaaagcg tttgaccaag ctgaaagaat ggtaggtttt ccgcttagaa aagctattgt 1544461 cggcgttaat ggaaattata tcaatattca agatacaaac ggtgttgtag cagtttccag 1544521 tgaaaataaa gaaattcagg ttgaagatgt acgccgtgtc atggaggcgg cacaggttgt 1544581 ttccgtaccg catgaacagc tgattgttga cgtcattcct aaacagttta tcgtagatgg 1544641 aagagatgaa atcaccgacc cgaaaaaaat gctgggtgtg cgtttagaag tagagggcac 1544701 cttgatcacc ggttcaaaaa caatcttaca taacttactc cgctgcgttg aaagagctgg 1544761 tattgaaata actgatattt gccttcagcc gctggcagcc ggttctgctg cattatcaaa 1544821 ggacgagaaa aaccttggtg tggctctcat tgatataggg ggagggtcaa caaccattgc 1544881 cgtattccag aacggacatc tcacttctac ccgtgtcatt cctctcggag gcgaaaatat 1544941 caccaaagat atctccatcg gattgagaac gtcaacagaa gaagcagaac gcgtgaaaaa 1545001 gcaacttgga catgcctact atgacgaagc ctcggaagat gaaatatttg aggtaaccgt 1545061 tataggcacc aatcaaaaac aaacatttac acagcaagaa gcagcgaata tcattgaagc 1545121 gagagtagag gaaattcttg aaattgtttc agaagagctt cgcagtatgg gaattaccga 1545181 tctgccggga ggcttcgtgc tgacaggagg acaagcagct atgccgggtg tcatgtcttt 1545241 ggcacaggat gtgctgcaaa acaatgtcag agtggcaagc ccgaattata tcggtgtaag 1545301 agatcctcaa tatatgacgg gagtgggcct gatccaattc gcctgccgga atgcaagaat 1545361 ccaaggcaga aaaataggct ttaagatgcc tgaagaagcg atacaggaaa tcgcagtctc 1545421 atcatctgag gaacaagagc agcatcatca ccaaaatgag gtgcagcagc ggccaaaagg 1545481 aaaacaaaaa acacaagccg aacataataa acagagcaaa atgaaaaaac tattaagcat 1545541 gttttgggaa tagatagata gtcattcggc agattaggag gatttagcat gttggagttc 1545601 gaaacaaaca tagacggctt agcatcaatt aaagtaatcg gagtaggagg cggcggtaac 1545661 aacgccgtta accgaatgat tgaaaatgaa gtgcaaggag tagagtatat cgcggtaaac 1545721 acggacgctc aagctcttaa cctgtcaaaa gcagaagtga aaatgcaaat cggcgcaaag 1545781 ctgactagag gattgggagc aggtgcgaat ccggaagtcg ggaaaaaagc cgctgaagaa 1545841 agcaaagagc agattgaaga agcacttaaa ggtgctgaca tggtattcgt gacagctggt 1545901 atgggcggcg gaacaggaac aggtgccgca ccggttatcg cacaaatcgc gaaagactta 1545961 ggcgcattaa cagtcggcgt tgtgacaaga ccgtttacct tcgaaggacg caaaagacag 1546021 cttcaggctg caggcggaat ctcggcaatg aaagaagcgg tggatacact gatcgtgatc 1546081 ccgaacgacc gtatccttga aattgttgat aaaaacacac cgatgcttga agcattccgc 1546141 gaagcggata acgtacttcg ccaaggggtt caaggtattt ctgacttgat tgctacacct 1546201 ggtcttatca accttgactt tgctgatgtg aaaacaatca tgtcaaacaa aggatctgct 1546261 ttgatgggta tcggtattgc tactggggaa aatcgcgcgg cagaggcagc aaaaaaagca 1546321 atttccagcc cgcttcttga agcggccatt gacggtgcgc aaggcgtcct catgaacatc 1546381 actggaggaa caaacctcag cctatatgag gttcaggaag cagcagacat tgtcgcttcg 1546441 gcgtctgatc aagacgtaaa catgattttc ggttctgtta ttaatgaaaa tctaaaagat 1546501 gagattgtgg tgacagtgat tgcaaccggc tttatcgaac aagagaagga cgtgacgaag 1546561 cctcagcgtc caagcttaaa tcaaagcatc aaaacacaca atcaaagtgt tccgaagcgt 1546621 gagccaaaac gtgaggaacc tcagcagcag aacacagtaa gccgtcatac ttcacagccg 1546681 gctgatgata cgcttgacat cccgacattc ttaagaaacc gtaataaacg cggctaatgt 1546741 aaaggacaaa atcgttttcg attttgtcct tttttgtttt tctcttcaca ctttccttct 1546801 tataaagtct ttttccctat tgcttccttc gcttagtaac aaaacagata attagaccca 1546861 tttatttttg tgacattttt atcattttca tatatatgga aattgaatga catgaaacga 1546921 caatatctgt aattcagatt gtctacagtt aatatacagc gatgttctga caaaccattc 1546981 attattaaaa ggagggacga cacttttttt aaaaagcatg ttgaaaaagg gggatgaaaa 1547041 tgaggaaaaa aacgaaaaac agactcatca gctctgtttt aagtacagtt gtcatcagtt 1547101 cactgctgtt tccgggagca gccggggcaa gcagtaaagt cacctcacct tctgttaaaa 1547161 aggagcttca atctgcggaa tccattcaaa acaagatttc gagttcatta aagaaaagct 1547221 ttaaaaagaa agaaaaaacg acttttctga ttaaatttaa agatctggct aacccagaaa 1547281 aagcggcaaa agcggctgtt aaaaaagcga aatcgaagaa gctgtctgcc gctaagacgg 1547341 aatatcaaaa gcgttctgct gttgtgtcat ctttaaaagt cacagccgat gaatcccagc 1547401 aagatgtcct aaaatacttg aacacccaga aagataaagg aaatgcagac caaattcatt 1547461 cttattatgt ggtgaacggg attgctgttc atgcctcaaa agaggttatg gaaaaagtgg 1547521 tgcagtttcc cgaagtggaa aaggtgcttc ctaatgagaa acggcagctt tttaagtcat 1547581 cctccccatt taatatgaaa aaagcacaga aagctattaa agcaactgac ggtgtggaat 1547641 ggaatgtaga ccaaatcgat gccccaaaag cttgggcact tggatatgat ggaactggca 1547701 cggttgttgc gtccattgat accggggtgg aatggaatca tccggcatta aaagagaaat 1547761 atcgcggata taatccggaa aatcctaatg agcctgaaaa tgaaatgaac tggtatgatg 1547821 ccgtagcagg cgaggcaagc ccttatgatg atttggctca tggaacccac gtgacaggca 1547881 cgatggtggg ctctgaacct gatggaacaa atcaaatcgg tgtagcacct ggcgcaaaat 1547941 ggattgctgt taaagcgttc tctgaagatg gcggcactga tgctgacatt ttggaagctg 1548001 gtgaatgggt tttagcacca aaggacgcgg aaggaaatcc ccacccggaa atggctcctg 1548061 atgttgtcaa taactcatgg ggagggggct ctggacttga tgaatggtac agagacatgg 1548121 tcaatgcctg gcgtgcggcc gatattttcc ctgagttttc agcggggaat acggatctct 1548181 ttattcccgg cgggcctggt tctatcgcaa atccggcaaa ctatccagaa tcgtttgcaa 1548241 ctggagcgac tgatatcaat aaaaagctcg ctgacttttc tcttcaaggg ccatctccat 1548301 atgatgaaat aaagccggaa atatctgcac cgggcgttaa tattcgttca tccgttcccg 1548361 gtcagacata tgaggatggt tgggacggca catcaatggc agggccgcat gtatccgctg 1548421 ttgctgcact gctgaaacag gcgaatgcct cactttctgt tgatgagatg gaggatatat 1548481 taaccagcac ggctgaaccg ctcacggatt caacatttcc tgattcaccg aataacggat 1548541 atggccatgg tctggtgaat gcttttgatg ctgtatccgc tgttacagat ggattaggga 1548601 aagcggaagg acaagtttct gtagaggggg atgaccaaga gcctcctgtc tatcagcatg 1548661 agaaagtaac tgaagcttat gaaggtggca gcctaccact gactttgaca gctgaagaca 1548721 atgtgagtgt gacatctgta aagctgtcct acaagcttga tcaaggtgaa tggacagaaa 1548781 taacggctaa acgaatcagc ggtgatcatc taaaaggaac gtatcaggca gagatcccag 1548841 atataaaagg aactaaacta agctataagt ggatgattca cgattttggc ggtcatgtcg 1548901 tttcgtctga cgtatacgat gtaacagtga aaccaagcat cacggcggga tataagcagg 1548961 actttgaaac tgcacccggc ggctgggttg cgagcggaac aaataataac tgggaatggg 1549021 gagttccgtc aactggccca aatacagcag catccggaga aaaagtatat ggaacgaatt 1549081 tgacaggaaa ttatgccaac tcagcaaaca tgaaccttgt tatgcctcct attaaagcac 1549141 ctgattcagg aagtctgttc cttcaattta aaagctggca caatttagag gatgattttg 1549201 attacggcta cgtttttgtt cttccggaag gtgaaaagaa ttgggagcag gctggtgtct 1549261 ataacggaaa gacatcaagc tggacggacg aagaaattga tttatcggct tataaaggcc 1549321 aaaacattca agtgatgttt aaccttcaat ctgatgaaag cattgcaaaa gagggctggt 1549381 atattgatga tgtagtgctt tctgacaaat cagccggaaa aacagtcaaa aagaataagc 1549441 tgggcgtcga aaagccgtct ggaaagcaaa agaaaaagcc agtaaatccg aaaaaggcta 1549501 agccatctgc aaacacagcg gtaaaacatc agaacaaggc tatacagcct caagttttgc 1549561 cgctcaaggc acaagtcagt gtagtggaaa caggaaaatc aacatattca gatcaatcca 1549621 cagggcagta cacgctgaag cacaaagcgg gagactatac gcttatggca gaagcatatg 1549681 gttatcagtc gaaaacacaa aaagtatctt taaagacgga tcagacgaca caagctaatt 1549741 ttacgttaga agagatgaag aagggcacat taaaaggcac ggtcatcaat aaaacgacag 1549801 gagagccggt aacaggcgct tccgtttatg ttgtagagga tgctgcggtg gaaccggcta 1549861 tgacaaacga caaaggtgaa tatatgctgg aggcctatga aggcgcttat acgattaaag 1549921 tcgctgcacc gggttattac agtgatgaat tttccgttga gttaaaaggt gatgttacaa 1549981 aagaaactgc attgaagcct ttcgtcggtt atccgggtga aattgcatat gatgacggaa 1550041 cagcggagaa tgccaattcc tattttgctg ccggtaacgg atgggcggta aaaatgacgc 1550101 tcgctgacgg caaggacaaa ggcatgctta caggagggct gttcagattc tgggatacag 1550161 agttccctga tccgggcggc acagagttta aggttgaggt atacgatgcc acaggaaaag 1550221 acggagcacc gggcaagaaa attgcagggc catttaacgc ggaagctctt cgcaatggcg 1550281 agtggactaa ggtagatctc agttcaaaag ggattatggt cgataaagat ttttatctcg 1550341 tatatatcca gtcgaaacct gatccgtatt cacctggatt ggcaatggat gaaaccggcc 1550401 agaattccgg ccgcaactgg cagtatatag atggaaagtg gcagccaggt gacaaagcgg 1550461 atggcaacta tatgattcgc gcattagttg attatgaagc tgctgtacct gagattactt 1550521 caccgacaga caaatcatac acaaataagg atagcgtcac tgtaaaagga aacgcttctc 1550581 ctggcacaac ggtacacatt tataatggag agaaagaagc aggagaaacg aaagctgctg 1550641 cggatggcac gttccatgca ggcatcatac tcaacaaggg tgaaaatgag ctgacggcaa 1550701 ctgcatcaac tgacaacgga acaacagatg cctccagccc aatcacggtc acgcttgatc 1550761 aagaaaagcc tgaattaaca ctggacaatc caaaggatgg cgggaaaaca aataaagaaa 1550821 cgctgactgt caaaggggct gtatccgatg acaatctgaa agacgtcaag gtgaatggca 1550881 aaaaagcaac agtagctgat ggttcatact cagcccgtat tcttttggaa aatggaagaa 1550941 atgaaatcaa ggtaattgct acagacttgg caggcaacaa aacgacgaaa aagacagtca 1551001 ttgatgtgaa ctttgacaag cctgtcattt ccggcttaat tccgggagag gataaaaact 1551061 taaaagccgg tgaatctgtg aaaatcgctt tctcaagcgc tgaggattta gatgcaacgt 1551121 ttaccattcg tatgccgctg accaatgcaa gagcgagtgt gcaaaatgcc accgaactcc 1551181 cgttaagaga aatctctccg gggagatatg aaggctattg gactgccact tcttctatta 1551241 aagcaaaagg agcaaaagta gaagtgatcg tccgagatga ttatggaaat gaaacaagaa 1551301 aaactgcgaa tggaaaactt aatatgaaca cagaaaatta agtggaaaaa aagctgccgt 1551361 cattggcagc tttttttata tcctctcatt atacttcctc gacaaattaa gcagatttcc 1551421 ctgaaaaatt gtattttcct ctcaacatta attgacagac tttcccacag agcttgcttt 1551481 atacttatga agcaagaagg ggaacagcgt gaggcaagaa agaaaggagt cagatgtgaa 1551541 aatctattta gatgtcattt ggctgttaaa cttttgtttt gatgcacttt tgcttttgct 1551601 cacggcattt attttaaaac ggcatgtaaa aaaaagaaga ctggtaggcg gagcgttcat 1551661 cggttccagt attgtccttt tgatgtttac tcctttttcg ccgattgttg aacatccggc 1551721 tgggaagcta gctttttcag ttgtgattgt ggtggtgaca tttggcttta aaagatttcg 1551781 gtttttcttt caaaatttgt tttcctttta ttttgccact tttttaatgg ggggaggaat 1551841 tatcggagcc cattctttgc tgcagtcaaa ttctattgtt caaaacggtg tcatgattac 1551901 caatcaaaca gggtttggag acccgatcag ctggttgttt attgttggtg gctttccagc 1551961 attatggttt ttttctaaaa gaagaattga agatattgaa acaaaaaaca ttcaatatga 1552021 ggaacgagtc agcgtgcagg cagatttggg cagccaaaca cttcatgtca gaggcctgat 1552081 tgattccggt aaccagctgt acgatcctct tacaaaaaca ccggtaatga tcatttacat 1552141 tgataaactg gagccgattt tcggaacagc cgaaacgatg atcattcgaa acacagaccc 1552201 attggaagcc atcgaacagc tcgatgattc ctttcgcttt ttagataaaa tgaggttgat 1552261 tccatacagg ggagttggtc agcaaaatca atttttatta tgcgttaaac cggatcacgt 1552321 aacgattatg acaaaagaag aaatgatttc tgcagataaa tgtttaatcg gtatcagcac 1552381 aacaaagctg tcggcagatg gagagtttga cgcgattatt catccgaaaa tgctttcggg 1552441 caaggctgtc aaacacgttt cataatgttc gcaaatgtcc gttacttatc atactcaaac 1552501 ggcgtgacat ttagaaggga gaggaagatg aaaaaactga aattacggtt gacgcacctc 1552561 tggtataagc tgctgatgaa acttgggctg aaaagtgatg aagtctatta cataggcggg 1552621 agtgaagccc tgccgcctcc attatctaaa gatgaggagc aggttttgtt aatgaagctc 1552681 ccaaacggcg atcaggcggc gcgcgccatt ctaattgaac gcaatttgcg tctggtcgta 1552741 tatatcgccc gtaaatttga aaatacggga attaatatag aggatttaat cagcatcggt 1552801 accatcggtc taatcaaagc tgttaataca tttaatccag aaaagaaaat caagcttgct 1552861 acctatgcct cccggtgtat agaaaatgaa atcctgatgt atttaagaag aaataacaaa 1552921 atccgttcag aggtttcctt tgatgaaccg cttaatattg attgggacgg caatgagctt 1552981 ttgctttctg atgtgctcgg cactgacgat gacatcatca ctaaagacat agaagctaac 1553041 gtcgataaaa agcttttgaa aaaagcgctt gaacagctta atgagagaga aaagcaaatc 1553101 atggagctgc ggtttgggct tgtcggtgaa gaagaaaaaa cccaaaagga tgtagcggat 1553161 atgatgggga tttctcagtc ttatatttcg cggcttgaga aaagaattat aaaaaggttg 1553221 agaaaagagt tcaacaaaat ggtgtaaaaa attttatggt tagaacccct tgattttaca 1553281 gggatttcct gatttcgaca gtttttcggt ctgagtgcag tgcatatttt tcccacccaa 1553341 ggagatactt aacgttgtac agcagctcct gtagggaggg aaaaaagtgt cgagaaataa 1553401 agtcgaaatc tgcggggtgg atacctccaa attaccagta ctcaagaatg aagagatgag 1553461 aaagctgttt aggcagctgc aggatgaagg cgatgattca gcaagagaaa agcttgtaaa 1553521 cgggaacttg cgtcttgtct taagtgtcat tcaacgattt aataacagag gggagtatgt 1553581 tgatgactta tttcaagtcg gctgcatcgg actaatgaaa tccattgata attttgacct 1553641 aagccacaat gttaagtttt caacatacgc tgtacctatg attatcggag agatccgcag 1553701 gtatttacgt gataataacc cgatccgtgt ctcaagatca ctccgggaca tcgcttacaa 1553761 ggcgcttcag gtaagagagc ggttaatcag tgagacaagc aaggagccga ctgcagaaga 1553821 catcgcaaaa gttcttgaag taccgcatga ggaaattgta tttgcgcttg atgccattca 1553881 ggatccggtt tctctatttg aaccgatcta taacgacggc ggagacccga tctatgtgat 1553941 ggaccaaatc agtgatgagc gtaatacaga ttcacaatgg attgaagagc tggctttaaa 1554001 agagggcatg agaaggctga acgataggga aaaaatgatt ttgagaaagc gattcttcca 1554061 agggaaaacc caaatggaag tcgccgagga aatcggaatt tctcaagcgc aggtgtccag 1554121 acttgaaaaa gcggctatca aacaaatgaa taaaaatatt catcaataat gaaaagcctt 1554181 taaaacgatg ttgttttaaa ggcttttcta ttgattatgg atggtttacg ttttggaaaa 1554241 agtaaggtat cctagttcgt acaaagtttt atgaaaatta aaacaattat aaaaggcaat 1554301 aaagaggagg accacgatga ttttgcagct tgacaatgtc tcactaaaac ggaatgggaa 1554361 atggatactg aaagatattc attggaaggt ggaagaaaag gaaaattggg tgctttacgg 1554421 cctaaatggc gccgggaaga cagcgctgtt aaatatgctt tgctcatatt attttccaac 1554481 atcaggcgag atgcaggtgc tcggccatga atttggcaaa acagagcttg gggaaaagct 1554541 cagacgtaaa attggcctcg tctcagcagc tcttcagcaa aaattgtatc cggcagattc 1554601 agcttttgaa attgctttga gcggagctta cgcttcgatt gggttatatg aaacgccaag 1554661 taaggaaacc agggaaaaag cgataggttt gttagaggac ttgggagcaa ttgaatatgc 1554721 cgatcgccgc tatgaaaccc tttctcaagg ggaaaaacaa agagcattga ttgctagagc 1554781 actaatggcc gatccggagc tgctgatact ggatgaacca gtcacaggac tggattttat 1554841 tgcccgggaa aagctgttag atacgattac atacattgca aacaaagaaa atgcaccatc 1554901 tatcctttat gtgactcatc atgctgaaga aattttgcct gtctttgata aagccctttt 1554961 attaaaacag ggagaggttt ttggatccgg agaaataaag gaaatgctta ctgatcaaat 1555021 actttccgct ttttttgata cgccaatcca tgtattatgg aatcaggatc ggccgttttt 1555081 aacaagagct gagccgataa cgaatgcctg acaaatatat atagattcat cctaggggtg 1555141 ctttgcgaag ctgagagaga ctttgtctca acccttttga cctgatctgg atcatgccag 1555201 cggagggaag cggtgaaaag cggagtacat cggactccgt ttgtttttat taagccgttt 1555261 catcacattt gaaacggctt ttttgatttt aaagaatagg agcggattta cattggatca 1555321 acaaatatac tctttgcaaa aaaaagtgga agaacataag gaggagctta ttcagcttgc 1555381 gaaaacgctg atttcttatc aaacacctgc tccgcctgca agaaatacag agggcattca 1555441 gtcttggatt gcgggatatt taaatgaatt gggattctcg atcgacaaat gggatgtgta 1555501 ccctggagat cccaatgttg tagggaagct aaaaggaaca gattcagcag attattatag 1555561 cctgattatc aatggccatg tagatgtggc agaggtaaaa gaggatgaag aatggaagca 1555621 cgatccgttt catcccattg aaaaaaacgg tctcttaatc gggcgaggcg cttccgatat 1555681 gaagggcgga atggcttgtg tgctgtttgc tgtcaaatta attcgtgaag caagcattga 1555741 acttccaggt gatctgattc tgcaatcggt tattggggag gaagttggag aggccggcac 1555801 acttgaatgc tgcaagaggg gctaccacgc tgattttgca attgtcgcgg atacgagcga 1555861 tatgcatatt caaggccaag gcggtgtcat tacaggctgg atcgaaatca aaagcagtca 1555921 aacatttcat gatggaacga gacggaatat gattcatgca ggcggaggaa cattcggagc 1555981 aagcgcaatt gaaaaaatgg caaaaatcat tgcggggctc ggtgaacttg agcgccactg 1556041 gtctattatg aaaagttatc ccggttttaa accaggcaca aatacgatta acccggcagt 1556101 tatagaaggc ggcagacatg cggcttttat agcggacgaa tgccggctgt ggatcacagt 1556161 ccatttttat ccgaatgaaa cccatgacca agtggcagcg gaaatagaag attacgtcaa 1556221 tcggctgagt gacagtgata tttggcttag ggaaaaccgc cctgtattca agtggggagg 1556281 ctcatctatg atagaagaca ggggagaaat ttttccggca ttggaagttg accctggcca 1556341 cccaggcgtc ttagcgctaa ctgcctctca tcagaaagtg aaacgggagt gtccaattat 1556401 tgacgtttct caatcagtta cagatggcgg atggctgtat gatgccggta ttccatgcgt 1556461 aatatacggt cctggagatc tgcacaatgc acactctgtg aacgagaagg tatcgattga 1556521 gcagctagta gagtatacaa aaattatact cgattttatc atcagctggt gcagccggaa 1556581 aaaagaacaa tgacatgaaa atttcttctt gctgacaagg ttcagcctgc ccgttcatat 1556641 acttgaacaa aaggacggaa aaaggacgtg atggaatgat cagcatttca gaatttcagg 1556701 taaaggatgt cgtcaatgtc tcaaacggaa aaaagctggg gagtattggt gatattgata 1556761 tcaatgtgac cactggaaaa attcaggcga tcatactcgg aggaaatggg aaagttctcg 1556821 gattttttgg aaaagaagag gaattggtca ttccatggcg aaatatagta aaaatcgggg 1556881 aagatgtaat cttagtccga ttaagtgaac cacatgcata aacctgcttg tctgccgcag 1556941 attggcaaat gccggaagtc tcgattcttc cggcacattt catttagaaa tatgcaaatc 1557001 ggcgctcaac gaatgcagta agatgtggta aaataagtgg gaaattccgc ttttttaaat 1557061 gtttgtcgaa aggttggatc atcatgaata catatcaccc attcagtctt accacaccct 1557121 cgacactcat gatacaagac tgggctcaaa cgaatcaaaa caacaaagag gtcattgccg 1557181 gatttacgac aaaaaacggc ggtgtcagcc aaaagccttt tgaatcgtta aatacaggat 1557241 tgcacgttca tgacaaagat gcagatgtag ttaaaaatcg tgaatatatt gccgatatgt 1557301 ttaatactga tttgcagtct tgggtattcg ctgatcagac acatgataat cgcgttcaga 1557361 aagtgacgca gagggatagg ggaaaaggcg cccgtgagta tcacacggct ctaaaagcaa 1557421 cggacgggat ctatacaaat gaaaaaaatg tatttttagc attatgcttt gctgattgtg 1557481 tgcctctttt cttttatgat ccggttaagt cgcttgtcgg agtcgcccat gccgggtgga 1557541 aaggcaccgt caaacagatt ggcagagaaa tggtgaagca atggactgag aaggaaggtt 1557601 caaatccctc agatatttac gctgttattg gcccgtctat cagcggagca tgctatacgg 1557661 tagacgaccg cgtcatggat gctgtccgcg cattgccggt ttcagcagac cttgccgcca 1557721 atcagacggc aaaggcacaa tatcagcttg atctgaaaga gctgaaccgt cttatactga 1557781 tggacagcgg tttggcaagt gaacaaattt ctgtcagcgg tttatgcacg gaaagcgagc 1557841 cgtctctttt ctattctcat cgccgcgatc aggggaaaac tggacggatg atgtccttta 1557901 tcggaatgaa ggaggcataa aagatcttgc gtgttgttga taatttacga catataaacg 1557961 aacgaataaa cgaagcatgt aacagatcgg gccgcagctc cgatgaagtt acggttattg 1558021 cagtcacaaa atatgtatca cctgaaagag cacaggaggc agtagatgct ggcatcacct 1558081 gcctcggaga gaatcgggat gcggaactgc tccgcaaaca ggaattgatg aaagggaatc 1558141 cggaatggca ttttatcggc agtctgcaat caagaaaagc aaaatctgtc gtcaattcgg 1558201 tttcctatat ccattcccta gaccggctct cattagcgaa agaaattgaa aaacgggctg 1558261 aaggtactgt acgatgcttt gtgcaggtca atacctctct tgagccttct aaacatggca 1558321 tgaaaaaaga agaagtcatt ccattcatac aggagctttc cggtttcgaa catatccttg 1558381 ttgccgggct gatgacaatg gctccgctga ctgatgatca agatcagatc agaagctgtt 1558441 tcaggtcgct gagagaactc cgtgaccagg ttcagaagct gaaccagccg aacgctccgt 1558501 gtactgaact gtcgatgggc atgtcaaatg attttgaaat tgcaattgaa gaaggagcta 1558561 cttatattag aatcggctca tcgttagtcg gaaatgaaac agggggtgta cagcaatgag 1558621 tatgaaaaat aaactgaaaa actttttctc aatggaagat gaagaatacg aatatgaata 1558681 tattgagaca gagcgggaat ctcatgagga gcatgagcaa aaagaaaagc cggcttacaa 1558741 cgggaataaa cctgcgggca aacagaatgt agtgagcttg caaagtgttc agaaatcctc 1558801 taaagtggtg ttgagtgagc cgcgcgttta tgcggaggcg caggaaatag ccgaccattt 1558861 gaagaaccgg cgggcagttg tcgtcaatct tcagcggata cagcatgacc aggcgaagcg 1558921 gattgttgac tttttaagcg gaaccgttta tgccattggc ggcgatattc aaagaatcgg 1558981 ctcagatatt ttcctctgca cgcctgacaa cgtagatgta tcaggcacaa tttctgagct 1559041 catatctgaa gacgaacatc agaggtggta aagcgagatg atcctttatc aagttttttc 1559101 ggttttaagc ttattaatca caatatactc atttgccctg atcatatata tttttatgtc 1559161 atgggtgccg agtacgaggg aaacagcagt cgggcgtttt ttggcttcga tttgtgaacc 1559221 atatctcgaa ccattcagaa aaatcatccc tccgattgca atgctggata tttcaccaat 1559281 cgtagcaata cttgtgcttc ggtttgcgac aaccggcttg tggggacttt atcgcatgat 1559341 tgcgttttaa tgtgacagtt tgataggggc ttggcagcag ccaagcctct ttacatagaa 1559401 gggaaagacg atgagcgata tatatcagca cttcagaaaa gacgagcggg cctttattga 1559461 tcaagcgctc gaatggaaaa gaattgtcca ggagcagtac cggatgaagc tgaccgactt 1559521 tttagatccc cgagagcagg tcatcctctc tgctgttacg ggacaggcag atgtcgggct 1559581 tgccttttcc ggcggctatg acagagcgga gcggaaacgg gcgattctgt ttccagagta 1559641 cattactccg gaagaatcag attttgaact gcaggcgttt aacgtccgtt atgctgacaa 1559701 gtttgtctca gtagatcatc gttctctgct tggtgcatta atgggcatag gattaaagcg 1559761 gcaaaaattc ggtgacatcg tgttttctga gacagcagtg caattgattg tctcagccga 1559821 taccgctgat tttgtggctg cacagctgac ccaagcaggc aaagcggcgg tcagcctaga 1559881 gaaaatcgac ttgtcagacc ttaacattcc agcagttgat gtcgaaataa gagatgacac 1559941 ggtttcttct ttaaggcttg acgccgtctg cgcctctatg agcaggcaat cccgccagaa 1560001 atcacagacg cttgtgaaaa acggccttgt gaaagtgaac tggaaggtgg ttgaagatcc 1560061 ttcatacata gtcgcggaag gggacatgct gtctatcaga ggttttggcc ggtgcagctt 1560121 aacaaaaatc gaaggaaaaa ccaaaaaaga caaatggaga gttacgtttg aacgacaaaa 1560181 atagtcggtt tttcagtttt tttctccatc tgtgcgaaat ttgttttata atgtgaacta 1560241 gataaccgta ctgaaatgta aaaatggagg tggcatcatg ccattaacgc caaatgatat 1560301 tcacaacaag acgtttacaa aaagttttcg cggatatgat gaagatgaag taaatgaatt 1560361 cctagcccaa gtcagaaaag attacgaaat tgttctccgc aagaaaactg agcttgaagc 1560421 gaaagtcaat gagcttgatg aaagaatcgg acactttgcc aatattgagg agacattgaa 1560481 taaatcaatt ttagttgctc aagaagcggc tgaagacgta aaacgcaatt ctcaaaaaga 1560541 agcaaagctg atcgttcggg aagcggagaa aaacgctgat cgcattatca acgaatcgtt 1560601 atcaaaatca agaaaaattg caatggaaat tgaagagctg aaaaaacagt ctaaagtgtt 1560661 cagaacacgt ttccaaatgc tgattgaagc tcagcttgat cttctgaaaa atgacgattg 1560721 ggatcatctc cttgagtatg aagtcgacgc tgtatttgag gaaaaggaat aaattctctg 1560781 attatcttga cattttctta gcttgtcgaa tataatacgt tcataaattc agatgaaaaa 1560841 acggttgaaa gggacagtca tgtttccttc aggccttcat agcgacccgg agatggtgag 1560901 agtccgggat ggccggaatc atgtagatca gccctttagt ttccttgctg aactcacagt 1560961 aggttaggac gttcatcacg ttacgatgct caagaggaaa aagtgtatgc ttgctttttc 1561021 taaaagggtg gtaccgcgag ataagctttc tcgtccctta tgggatgaga gggctttttt 1561081 tattttctga aaaaatgcag tggaggaatg aaaatggatt ttaaagacac gctcttaatg 1561141 ccgaaaacag atttcccgat gcgtggaaat ttgccaaacc gtgagcctga cattcaaaaa 1561201 aaatgggagg aagaagatat ctaccgtctt gttcaggaac ggacgaaaga ccgcccgaaa 1561261 tttgttttac atgacggacc tccgtatgca aacggcgaca tccatatggg ccatgcactt 1561321 aacaagattt tgaaagactt cattgtccgc tataaatcaa tgagcggcta caacgcaccg 1561381 tatgtgccgg gctgggatac acacggattg ccaattgaaa cagctctgac aaaaaacaaa 1561441 aaggtcaacc gcaaagaaat gtcagtagcg gaattccgca aactatgcga agagtacgct 1561501 tggaagcaaa tcgagggaca gcgtgagcaa ttcaaacgtc ttggtgtccg cggtgactgg 1561561 gaaaacccat atgtgacatt aaaaccggaa tacgaagcgc agcaaatccg cgtatttggt 1561621 gaaatggcaa aacgaggcta catttacaaa ggccttaaac cggttaactg gtcaccttca 1561681 agtgagtctg ctctggctga agccgagatc gaatatcaag ataaacgttc agcatctatt 1561741 tacgtcgctt ttggtgtaaa agacggaaaa ggcgttcttg aaaacggcga gcgcatcatc 1561801 atttggacaa caacgccgtg gacaattccg gcgaacctcg gaatctcagt gcaccctgat 1561861 cttgagtaca gcgtgattgc agtaggtgaa gaccgctttg ttgtagcaag tgccttagtc 1561921 gaaaatgttg catcggcatg cggatttgat cagtatgaag tgacaagaac ggtcaaaggg 1561981 aaagaccttg agaacattat cgctgaacac ccgctatatg gcagagactc tctcgttatg 1562041 cttggtgaac acgtaacaac tgatgccgga acaggctgtg ttcatacagc gcctggacat 1562101 ggggaagatg actttatcat cggccaaaaa tacggtttag atgtgctttg cccggtcgat 1562161 gaaaaaggtg taatgacaag cgaagctcct ggctttgaag gcatgttcta tgatgatgca 1562221 aacaaagcga tcacacagca gcttgatgaa aaaggcgcac ttgtgaagct tgaattcatt 1562281 actcattctt atccgcatga ttggagaaca aaaaaaccaa ccattttcag agcaacagcg 1562341 caatggtttg cgtctattaa agatttcaga tcagacctgc tggatgccat taaagaaacc 1562401 aaatgggttc ctgaatgggg cgagcagcgt ttgcacaaca tggttcggga ccgcggagac 1562461 tggtgtattt ccagacagcg tgcgtggggt gtgccgattc cggtatttta cgctgaaaac 1562521 ggagaaccgg ttattacaga tgaaaccatt gaacatgttt ctgaattgtt cagacagcat 1562581 ggatcaaaca tttggtttga aaaagaagca aaggatcttc ttccggaagg ctttacgcat 1562641 cctggcagcc cgaacggcac atttacaaaa gaacaggata tcatggatgt ttggtttgat 1562701 tcaggctctt cacatcaagc agtgcttgaa gaacgtgatg acctcgttcg cccggctgat 1562761 ctatacctag agggatctga ccaatatcgc ggctggttta actcttctct ttctacagca 1562821 gtagccgtaa cagggaaagc gccgtataaa ggtgtgctca gccatgggtt cgcactggat 1562881 ggagaaggac gtaagatgag taaatcaatc ggtaacgttg ttgttccggc taaagtcatg 1562941 aaacagcttg gtgccgacat cttaagatta tgggtatctt cagtggatta tcaggcggac 1563001 gttcgcgtgt ctgacgccat tctgaagcag gttgcggaag tatatcgtaa aatccgcaac 1563061 acgttccgtt tccttcacgg caaccttttc gattttgatc caaaaacaaa tgcggtggct 1563121 gtcgaagatc ttcgcgaagt ggatcagtat atgctgatta agctgaacaa gctgattgat 1563181 aaagtgaaaa aagcgtatga tgagtacgaa tttgcggttg tgtatcacag cattcataat 1563241 ttctgcacaa tcgaattgag ctcattctac cttgattttg caaaagatat tgtctacatc 1563301 gagcatgcgg atcatccgga tagacgcagc atgcagacag tattctacga aacgcttctt 1563361 gcattagtga agctttcagc gcctatcctt ccacatacgg cagacgaatt gtggtctcat 1563421 ttaacatttg ttgaagagca gagcgttcag ttgaccgata tgccggaaac aatcacggtt 1563481 ccaaacagtg aagcgactga agaaaaattt gaccgcttta tggctcttcg tgatgacgtg 1563541 ttaaaagcat tagaaactgc gcgaaatgaa aaaattatcg gtaaatcttt ggaagcaaac 1563601 ctgaaattgt atccaaacaa agaaaacaag gagctcttgg cttccataaa agaaaacctt 1563661 tctcagctgt ttattgtgtc tgaactgaca atcagcgaag aaaatgaagc gccgaacgat 1563721 gcgcaaagct ttgcgacggg taaaatcgct gtcgagaaag cggaaggcga aatgtgtgag 1563781 agatctcgtg tgatttcaaa agatgtaggg gcaaatccga aatatcctac actttcatta 1563841 cgcaacgctg aaatcgttga aaaatactat caaaaataat gcaaaagagc ccggcgtaaa 1563901 agccgggctt tttttgtgcc aagagtgaca tcctttagaa cgaaaggaaa aatcttatgg 1563961 gctttagatc atcattcaca ggcaacaata aagatactac gttaagagca ggagttgtga 1564021 agaatgaatg atcaactgac cgcaatttat acggaacttc ttctgatgaa agaagaatta 1564081 cagtcgagat tatttgagta ttcttgcttt caggtttcta caagcccgca agcagcaatc 1564141 aatcaaaaac aaaaagcaac tctgatctat catattaaag aagaacttca agacgttctc 1564201 cttgcattgt ccaaaatcga aaacggcaca ttcggatact gtgaagaaac tggggccccc 1564261 attcctcttg caaagctggc agtgctgccg acggcccgaa cagcaaacga ttttctttat 1564321 tctgtccaat ttgagaaaaa aacgcttccg atatggaaat caacggatat cgaatatggt 1564381 caggcactgt atgaataaca gtgtctgtcc ggttaatatg cctgatattt ctttactcca 1564441 gtgcttttta ttgataaaat gcataatgga ttaaagtaac cgtaaactgg aggaacgttt 1564501 gtgctgtatt atatgattgc actacttatt attgcagccg atcaattgac aaaatggcta 1564561 gttgttaaga acatggaact tggccaaagc attccgatca ttgatcaggt attctatatc 1564621 acctcccatc gcaatacggg tgctgcatgg gggatattag cgggtcaaat gtggtttttc 1564681 tacctcataa caaccgctgt tattattggt attgtttatt acatacagcg ttatacaaag 1564741 ggacaaaggc ttcttggcgt tgccctcgga cttatgcttg gcggtgccat cggcaacttt 1564801 atcgatcggg ctgtcagaca ggaagttgtg gattttatcc atgttattat tgtcaattac 1564861 aattacccga tatttaacat cgcggactct tcactatgtg tcggcgtaat gcttttattt 1564921 atacaaatgc tgttggacag cgggaaaaag aaaaaggagc aatagcatga atcaaattga 1564981 tataaccgct tcagaagaac aaaaaagtga gcggattgat aaatttttgg catcgactga 1565041 gaatgattgg tcaagaaccc aggttcagca atgggtaaaa gacggacagg ttgtcgtgaa 1565101 cggaagcgcg gtgaaagcga attataaaat tcagccgggt gatcaggtga ccgtcactgt 1565161 acctgaaccg gaagcgctcg acgtcctggc agagcctatg gatctggata tttattatga 1565221 ggaccaggat gtgctggtcg tcaacaaacc tcgcggaatg gttgttcacc cagcacccgg 1565281 gcatcttacg ggcacacttg taaacggtct tatggctcat tgcacagacc tttccggaat 1565341 aaatggtgtg atgcgcccgg gtattgttca cagaatcgat aaggacacgt ccggtttatt 1565401 aatggtggcg aaaaatgata tggcgcacga gtcactcgta aaccaattgg tcaacaaaac 1565461 ggtcacgcgg aaatatacgg cggttgtcca cgggcttatt tctcatgatg acggcacaat 1565521 tgacgcgccg atcggacggg ataaaaaaga ccgtcaaagc atgactgtga cacgtgatgg 1565581 caaaaacgct gtcactcatt ttcatgtgct tgagcgtttt caggatttta cgttagtgga 1565641 gtgccagctt gaaacaggga gaacccatca aattcgtgtt catatgaaat atatcggatt 1565701 cccattagca ggcgatccga aatacggccc aagaaaaaca atcgacttta atggccaagc 1565761 gcttcacgcg ggagttttag gttttgacca tccacgaaca ggagaatatg tcgaatttga 1565821 agcgccgctt cccgaggata tggcagaatt aatcgaaaac ctcagaaaaa acggttgaca 1565881 gagggtttct tttctgaaat aataaacgaa gctgaataga ttctttaaaa cagtccagag 1565941 aggctgagaa ggataacgga tagacgggat gcgtgtatag gcgcgcacct tgtcctaaaa 1566001 cccctctatg ctctggcagg aggggttttt tcttctatat gaactgtgag gtgtcacaca 1566061 ttgaatcaaa aagctgtcat tctcgacgaa caggcaatta gacgggcgct gaccaggatt 1566121 gctcacgaaa tgatcgaacg caataaagga atgaataact gcattcttgt cggcattaag 1566181 acaagaggga tttacctggc aaaacgcctt gcggaacgca ttgaacagat tgagggaaat 1566241 cctgttacag tcggtgaaat tgatattact ctttacagag atgatctttc taaaaaaaca 1566301 agcaacgatg aaccgcttgt aaaaggtgca gatattccgg tagatattac agatcaaaaa 1566361 gtcattctcg ttgatgatgt tctgtatacc ggaagaacag tcagagcagg aatggatgcg 1566421 cttgttgatg taggcagacc ttcctccatt cagcttgcag tgcttgtgga cagaggacac 1566481 cgggagctgc cgatccgagc ggattatatc gggaaaaaca tcccgacatc aaagtctgaa 1566541 aaggttatgg tacagcttga tgaggtagac caaaacgatc tcgtcgccat ttatgaaaac 1566601 gaataataga tcaccttttt aagggcaatc cagagaggtt gcaaagaggt gcacaacaaa 1566661 ggcccaaaaa gtattcggca ggtctttgta tgcctctttg cgtaaaaaag caaagaggtt 1566721 tttttataca gtcattgagt catcctaaaa tgaaagtcaa caatcagggg gaaatcatca 1566781 tgagtaagaa aaaagtaaat ttaggggtca gggatgtccc gacacctttc tcttgggttt 1566841 cattcagcct tcagcatttg tttgccatgt ttggctcaac cattttggtt ccgaagctcg 1566901 tcggaatgag tcctgctgtg gcgttggtga caagcggcat cggaacactg gcgtaccttc 1566961 ttattaccaa aggacaaatt ccggcgtatc tcggttcatc cttcgccttt atttctccga 1567021 tcattctggt aaaagcgacc ggcgggccgg gagcggcaat ggttggagcg tttcttgcag 1567081 ggctggtgta cgggctgatt gccttattga ttaggcagct tggaacagga tggctgatga 1567141 agattctccc gcctgtagtc gtagggcctg ttattatcgt catcgggctg ggactggcaa 1567201 gcactgcagt aaacatggcg atgtatgctg atccgaacgc gagtgagttg gtctacagct 1567261 taaagcactt tagtgtcgca ggagttacgc tggcaattac gattatttgt gcgattttct 1567321 tacgagggtt tttaagcctg attccggttc tgatcggaat catcggcgga tacctgtttg 1567381 cccttactca agggattgtc aacttccagc cggtgcttga cgcgaaatgg tttgcagtgc 1567441 ctgaatttat cattccgttc aaagattatt caccgtcagt tacgctcggc atcgcagccg 1567501 caatggttcc tgtcgcattt gtcacaatgt cagagcatat cggccaccaa atggtgctga 1567561 gcaaggttgt cggacaagac ttcattaaaa agccaggtct tcatcgctct attatgggtg 1567621 acagtgtggc gacaatcctc gcttccctga tcggcggccc tccgacaacg acttacggag 1567681 aaaacattgg cgtgctggcc atcacaagag tattcagcgt ctttgtcatc gggggcgcgg 1567741 cagtgattgc cctttgcttc ggctttatcg gcaaaatttc agcgctgatc agttcagtgc 1567801 cgtcagcggt catgggaggc gtctccttcc tgctgttcgg aatcattgct tcaagcggcc 1567861 tgagaatgct gattgacaac aaaattgatt atgaaaacaa cagaaacctc attattacat 1567921 cagttatcct tgtcatcggt gtaggaggcg cttttatcca agtgtctcag ggcggattcc 1567981 aagtgtcagg aatggcgctt gccgcaattg tcggtgtcat cttaaacctg attcttccgc 1568041 aggcgaagga agagcaggca gacacatctg aacaacatca tatttaaaac cttttaatga 1568101 aagtccagag aggcttggaa gggttatgaa gagaaggaag cttcaatgct gccctctatt 1568161 taaccatacc ccgagtctat cttagaccgg ggtttttttt cagccttaag ttgaaaagag 1568221 aggggaaaga acatgaagca tttaacgacg atgagtgaac ttagcactga ggaaatcaaa 1568281 gatttgcttc aaacagcaca agagctcaaa agcggaaaaa cagacaatca gcttacagga 1568341 aagtttgcag caaacctgtt tttcgaaccg agcacgagaa cgcggttcag ctttgaggtc 1568401 gcagaaaaaa agctgggcat gaatgtgctt aaccttgatg gaacaagcac aagcgtgcaa 1568461 aaaggcgaaa ccttatatga cacgatccgg acgcttgaat caatcggtgt ggacgtctgc 1568521 gtcatcaggc acagtgagga tgagtattat gaagagcttg tcagccaggt gaacattccg 1568581 attctgaatg cgggagacgg gtgcggccag catccaacac aatcactgct tgatttaatg 1568641 acgatttatg aagagttcaa tacgtttaaa gggcttaccg tctccattca cggcgacatc 1568701 aagcatagca gagtggcaag gtcaaatgcg gaagtgttga caagattggg tgcccgggtc 1568761 ctattttccg gcccttcgga atggcaggat gaagaaaata cattcggcac gtatgtctca 1568821 atggatgaag cagttgagtc ttccgatgtt gtcatgctgc tgcgcattca aaatgaacga 1568881 catcagtccg ctgtcagtca ggaaggctat ttaaacaaat acggcttgac cgtagaacgg 1568941 gctgagcgta tgaagcggca tgcgatcatc atgcatcctg ctccggtaaa cagaggagtg 1569001 gagattgatg acagcttagt agaaagcgaa aaatcaagaa tcttcaagca aatgaaaaat 1569061 ggcgtattta tcagaatggc agtgatacag cgtgccttac aaaccaatgt gaaaagagga 1569121 gaagcagcgt atgtcatatc tcattaaaaa cggctggata ctaaacgaaa atggtgaaaa 1569181 aacacaagcg gatatccgag tgactggaga aaccatcacc gcaatcggca agcttgatgc 1569241 aacggataat gaaacggtaa ttgatgcaaa aggtttgctc gtttcacctg ggtttgttga 1569301 tctccacgtg catttcagag agccgggcgg agagaaaaaa gaaactattg aaaccggggc 1569361 aaaagcagcg gcgcgcggcg gctatactac agtagcagca atgccgaata cgcggccggt 1569421 tcctgataca aaggagcaga tggaatgggt gcaaaacaga attaaagaaa catcatgcgt 1569481 aagagttctt ccatatgcat ccattacgat cagacaaatc ggcgatgaaa tgacaaactt 1569541 tgaagcgtta aaagaagccg gggcatttgc ttttacagat gacggcgttg gtatacagac 1569601 agcaggaatg atgtatgaag cgatgaaacg ggcagccgca attgacaaag cgattgttgc 1569661 acattgcgag gacaactcct taatttacgg agggagcgta catgagggga cattctccaa 1569721 agcgaacggg ctaaacggca ttccttctgt gtgtgaatcg gttcatattg ctcgcgatgt 1569781 gctgctggct gaggcggcaa actgccatta tcatgtatgc catatcagca caaaagaatc 1569841 tgtcagagtt gtacgcgatg cgaaaaaagc gggaatcaga gtgacagcag aagtatcgcc 1569901 gcatcatttg ctgctttgtg atgaggacat cccggggctg gacacaaact ataaaatgaa 1569961 tcctccgctc cgcagcccag aagacagagc tgctttaatt gaaggtcttt tagacggaac 1570021 aattgatttt atcgcaacag accatgcacc gcatacggaa gaagagaaga acacagaaat 1570081 gaagctggcg ccattcggaa ttgtcggctt agaaacagca ttcccgcttc tttacacaca 1570141 ctttgtcaaa aatggcagct ggtcactgaa gcagctgatt gactacatga caatcaagcc 1570201 atgcgaagcg ttcggtctcc catatggaac attacaaacg gggcaagctg cggacattac 1570261 gttaatcgat ttagaaaaag aagcagttat agacaaagag acatttttat caaaaggaaa 1570321 aaatacacca ttcaacggca tcagttgcac cggctggccg gtcgctacaa ttgcggcagg 1570381 gaagcttgct tatgaagagg ggagacttgt caaatgaaga gacgattagt actggaaaac 1570441 ggagcggtat tcgagggaga agctttcgga agcttagaac acaacatggg agaagtcgtt 1570501 tttaatactg ggatgacagg ctatcaggaa attttatctg atccttctta ctgcggacag 1570561 atcgtaacat taacataccc gcttatcgga aattacggca ttaaccgtga tgattttgaa 1570621 tccattaccc cttttgtcaa agggctgatc atcaaagaat tatgtgagct gccttccaac 1570681 tggcgttcag catacacctt agacgagtat ttaaaaatga aaaacattcc cggactccag 1570741 ggaattgata caaggaagct gacaagaatg atccgcacgg caggcgcgct aaaaggaaca 1570801 ttcgcttcat ctgatgaaga tatcgaagca gtgctgaaaa gactgaacga aacggaattg 1570861 ccaagaaatc aagtatccca agtatcagca aaaacagcat atccgagccc gggaagaggc 1570921 aaacgcattg tcttggttga cttcggcatg aaacacggga ttctaagaga gctgaacaaa 1570981 cggaaatgtg acgtcatcgt tgtgccttac aacattacag cggaagaggt gcttcagctg 1571041 aaaccggacg gtatcatgct ttctaacgga cctggagacc cgaaggatgt gcctgaagcg 1571101 attgaaatga ttaaaggtgt tcttggaaaa gtgccattat tcggaatatg tctcggccac 1571161 caattattcg cgctggcgtg cggggcgaat actgaaaaaa tgaaattcgg ccacaggggc 1571221 tcaaaccacc cggtaaaaga gctggctaca ggaaaagttg ccttaacatc tcaaaaccat 1571281 ggatatacag tttcgtctat cagtaaaaca gaactggaag tgacgcatat cgcaattaac 1571341 gacgatacga ttgaagggct gaagcataaa acattgccgg catttacggt tcaatatcat 1571401 cccgaagcct cacctggtcc tgaggatgcc aaccatctat ttgacagatt catcgaaatg 1571461 atcgaaacaa cagagaaaga aggggaagcg gtatgccaaa acgcgtagac attaacaaaa 1571521 ttttagtaat cggatctgga ccgatcatca tcggccaagc agcagaattt gactatgcgg 1571581 gaacacaagc ctgtcttgct ttgaaagaag aaggctatga agtcatcctt gtcaactcaa 1571641 accctgcaac gatcatgaca gatacagaaa tggctgaccg ggtttacatc gaaccgctca 1571701 cacctgaatt cctgacacga atcatcagaa aagagcgccc ggatgccatt cttcctacac 1571761 tcggaggcca aaccggtttg aatcttgcgg ttgagctttc tgaaagaggc gttttggcag 1571821 aatgcggcgt cgaagtgctt ggcacgaaac tgtctgcgat tcagcaagct gaagaccgtg 1571881 acttgttcag aacattaatg aatgaactga atgaaccggt gcctgaaagt gagattatcc 1571941 actcccttga agaagcagaa aaattcgtca gtcaaattgg attccctgtc attgtccgcc 1572001 cggcatatac attaggcgga acaggcggag gcatctgctc gaatgaaaca gagctaaaag 1572061 aaatcgttga gaacggcttg aaattaagcc cggtacacca atgtctgctt gaaaaaagca 1572121 tcgccggcta taaagaaatc gagtatgaag tcatgagaga cagccaggat cacgccattg 1572181 tcgtttgtaa catggaaaac attgatccag ttggaatcca tactggagac agtattgttg 1572241 tcgcgccgag ccaaacgctc agcgatcgcg aatatcagct cttgcggaat gtatcgttaa 1572301 aactgattcg cgcgcttggg atcgaaggcg gatgtaatgt ccagctcgcc ttagatccag 1572361 acagcttcca atattacatt attgaagtaa atccgcgtgt cagccgttca tctgcccttg 1572421 catcaaaagc aacggggtac ccgattgcaa agctcgctgc taaaattgca gtcggacttt 1572481 cattagatga aatgatgaac ccggtgacag gaaaaacata tgcagcattt gaacctgctc 1572541 ttgactatgt cgtatccaaa attccgcgct ggccgtttga taagtttgaa tcagcaaaca 1572601 gaaagcttgg cacgcaaatg aaagcgacag gtgaggtcat ggcaatcggc cgcacgcttg 1572661 aagagtcatt gctgaaggca gtgcgatcac tggaagcgga tgtgtatcat cttgaattga 1572721 aggacgccgc tgacatttca gatgagcttc ttgaaaagcg aattaaaaag gccggtgatg 1572781 aacgcttatt ctacttagct gaagcgtaca gaagaggcta cacggtagaa gacctccatg 1572841 aattttccgc tatcgatgtc ttcttcttgc ataagctgtt cggaatcgta cagtttgaaa 1572901 aagaattgaa ggccaatgcg ggcgatacag atgtgctgag acgggcaaaa gaactcggct 1572961 tctctgatca gtacatcagc cgtgaatgga aaatgaaaga atctgagctt tacagcttga 1573021 gaaaacaagc ggggattgcg ccggtattca aaatggtaga tacatgcgcg gcggaatttg 1573081 agtcagaaac gccatacttc tatagcacat atgaagaaga aaatgaatct gtcgttacag 1573141 ataagaaaag tgtgatggtg cttggttcgg gtccgattcg aatcggtcag ggtgtcgagt 1573201 tcgactatgc gacggttcac tctgtatggg caattaaaca agcaggctat gaagccatta 1573261 ttgtcaacaa caacccggaa accgtttcaa cagacttcag catctcagac aagctgtatt 1573321 ttgaaccgct tacgattgaa gatgtcatgc acatcattga cctcgaacag ccaatgggcg 1573381 ttgtcgtaca atttggcgga caaactgcga ttaaccttgc tgacgagctt tctgcacgcg 1573441 gagtgaaaat ccttggaact tcattagaag atttagaccg tgccgaagac cgggataaat 1573501 ttgaacaagc gcttggagaa cttggtgttc ctcagccgct tggcaaaaca gcgacatcag 1573561 ttaatcaggc ggtaagcatc gcaagtgata tcggttatcc ggtactggta cgcccttcct 1573621 atgtacttgg cggccgggcg atggagattg tttaccatga agaggaactg cttcattaca 1573681 tgaaaaatgc agtcaaaatc aatccacagc accctgtatt aattgataga tacttgaccg 1573741 gaaaagaaat tgaagtcgat gcagtatccg acggtgaaac agtcgtcatt ccgggaatta 1573801 tggagcacat tgaacgtgcg ggcgttcact ccggagactc aatcgctgtt tatccgcctc 1573861 agtctctcac agaggacatt aagaaaaaaa ttgaacaata cacgatcgca ttggctaaag 1573921 ggctgaatat tgtcggtttg ctcaatattc aattcgtctt gtcgcaaggc gaggtgtacg 1573981 tgctagaagt gaatccgaga tcaagcagaa ccgtaccgtt tttaagcaaa attacgggta 1574041 tcccaatggc gaatctcgca acaaaaatca ttcttggtca aaagctggct gcgtttggct 1574101 atacagaggg ccttcagcct gaacagcaag gtgtatttgt aaaagcgccg gtcttctcct 1574161 ttgccaagct gagaagagtg gatattacgt tagggcctga aatgaaatca acaggtgaag 1574221 tcatggggaa agattcgaca cttgaaaagg cgctctacaa agccttgatc gcttcaggta 1574281 ttcaaatccc gaactacggt tccgtgcttt taacagtagc tgataaggac aaagaagaag 1574341 ggcttgccat tgctaagcgg ttccacgcga tcggctacaa cattttagcg acggaaggaa 1574401 cggcaggcta cctgaaagaa gcttccattc cagcgaaggt cgtcggaaaa atcggtcagg 1574461 atggcccgaa cttgcttgat gtcatcagaa acggagaagc gcagtttgtc atcaatacgc 1574521 tgacaaaagg aaagcagccg gcaagagacg gttttagaat cagacgtgaa tcagtagaaa 1574581 atggtgttgc ctgcctaaca tctttagata cggcagaggc gatattgcga gtgctggaaa 1574641 gcatgacatt ccgtgctgat caaatgccgg cagtcaacac aaatcaggag gcggcagtca 1574701 ctatatgaaa aaagcgtatt tgacagtatg ttctaaccag caaattgcag accgggtgtt 1574761 tcaaatggtt ctgaaagggg agcttgtcca agggtttaca acccctggac agttccttca 1574821 tcttaaagtg agcgaagcgg ttacgcctct tttgagaagg ccgatcagca tcgcagacgt 1574881 caactttgaa aaaaatgaag tcaccatcat ttatcgggta gatggggaag ggacaagact 1574941 cttgtcactg aagcagcagg gagaacttgt ggatgtcctc gggcctttgg gaaatggctt 1575001 tcctgttaat gaagttcaac ccggaaagac ggctttgctg gtaggaggcg gagtaggtgt 1575061 gccgcctctc caagagctgt cgaaacgctt gattgaaaaa ggggtaaatg tcatccacgt 1575121 tttaggattc caatcggcaa aggatgtttt ttacgaggaa gaatgccggc agtacggaga 1575181 cacgtatgtg gcaacagctg acggaagcta cggggaaacc ggatttgtca cagatgtgat 1575241 taaacggaaa aagctagagt ttgatatcct cctcagctgc gggccgacac cgatgctcaa 1575301 ggcgttaaaa caggaatatg cccataaaga agtatatctg tccatggagg aacgaatggg 1575361 ctgcggaatc ggcgcatgct tcgcgtgtgt gtgccataca aacgaaagtg agacatccta 1575421 tgtaaaagta tgtctcgacg ggcctgtatt taaagctcag gaggtggcgc tgtaatgcta 1575481 gaggtgaaat tgccgggact tgatttgaaa aacccaatca ttcctgcatc aggctgcttc 1575541 ggttttggaa aagaattttc acgtttttat gatttgtctt gtcttggagc tatcatgatt 1575601 aaggctacga caaaggagcc gcgctttggg aatccgacgc cgcgggtagc tgagactggt 1575661 gctggaatgc tcaatgcgat cggtctccaa aatccggggc tggatagtgt gttgcatcat 1575721 gagctgccgt ggcttgagca gtttgataca ccgatcattg ccaatgtcgc aggttctcaa 1575781 gtcgatgatt atgttgaagt cgcagaacat atcagcaaag cgcctaatgt tcatgctctt 1575841 gaattgaata tttcctgccc gaatgtgaaa acaggcggaa tcgcttttgg cacgaatcct 1575901 gaaatggctg ccgatttgac aaaagcggtg aaagaggttt cggatgtacc cgtttatgtg 1575961 aagctatccc cgaacgtggc taatatcaca gaaattgcat tagcgatcga ggaagcggga 1576021 gcggacggtc ttacgatgat caacacacta atcggcatga gactcgattt aaaaaccggc 1576081 aaaccgatat tagcgaataa aacaggggga ctttcgggcc ctgctgtgaa gccggttgcc 1576141 attcgcatgg tgtatgaagt cagccagatg gtcaacatcc cgattatcgg aatgggaggc 1576201 gtgcaaacgg ctgaagatgc cctggaattt cttctcgcgg gagcaagcgc agtcgctgtc 1576261 ggaacagcaa actttgtgaa tccttttgca tgtccagaga ttattgaaca gctcccatct 1576321 gttttgctcc aatacggcta tcaatcaatt gaagaatgca tcggaaggag ctggaatcat 1576381 gaaaaacaac ctgcccatca tcgcgcttga ttttgcgtca gctgaagaaa cacttgcgtt 1576441 cttagcgcct tttcagcaag aaccgttatt tgtaaaggtt gggatggagc ttttttatca 1576501 agaagggcca tctatcgtga aacaactaaa agaaagaaac tgcgagctat ttttagatct 1576561 aaagcttcat gacatcccga ctactgtaaa caaagcgatg aagcgccttg ccagtcttgg 1576621 agtagacctc gtcaatgttc atgctgccgg gggcaaaaaa atgatgcagg cagctctcga 1576681 aggcttagaa gaaggtacgc cggctggaaa aaaacgtccg tcacttatcg cggtaaccca 1576741 gctgacaagc acatctgaac aaatcatgaa agatgaactg ctgatcgaaa agtctctgat 1576801 tgatacggtt gtgcactaca gcaaacaggc ggaagaaagc ggactggatg gagtggtctg 1576861 ctctgttcat gaagcaaaag ccatttacca agcggtgtcg ccttcatttc tgactgtcac 1576921 tccggggatc agaatgtcag aggacgctgc gaatgaccaa gttcgcgtag cgacgcctgc 1576981 cattgcaaga gagaaaggtt catcagcgat tgtagtagga cgctcgatta caaaagcgga 1577041 agacccggta aaagcctata aggctgtcag acttgaatgg gagggaatca aatcttgaaa 1577101 caaatcatcg caaaacatct attagacatc caagctgtat ttttacgccc gaacgagccg 1577161 ttcacatggg caagcggcat tttatcaccg atctactgtg acaaccgcct tacgctatct 1577221 ttcccagagg tcagaaacga tgttgcttca ggtatcagca agcttgttaa agagcatttt 1577281 cctgaagctg aaatgattgc gggaacagca actgccggta ttcctcatgc tgctcttgcg 1577341 gcggaccatt tgaatcttcc gatgtgttat gtgaggagca agccgaaggc gcacggaaaa 1577401 ggcaatcaga ttgagggagc tgtgcaagaa gggcaaaaaa cagtcgtcat tgaagactta 1577461 atttccacag gaggcagcgt gcttgaagct tgtgcagctt tacaagcggc cggctgtgaa 1577521 gtgcttggtg tcgtctcaat ctttacgtac ggacttccta aagcggagga agccttcgca 1577581 aaggcagaac tgccatacta ctcattaacc gattatgata cgctcacaga ggtcgcgctt 1577641 gaaaacggaa atattcattc agatgatcta aaaaagctgc aaacatggaa acgaaatccc 1577701 gagtcaaaag attggtttaa aaaataaaaa ataaattcaa atgatgtaaa gaggcttcaa 1577761 agccttgctg tacttgaaaa caggctgtga ggcctgtttt tttattaatc ctataaaaaa 1577821 agtcgggttg acttatgtta gaattgtgct aaaatttact acaaatctaa aaacttatca 1577881 agagcggctg agggactgga cctatgaagc ccggcaacct gcatagtttg taaggtgcta 1577941 cttccagcaa aatgaattcc attttgaaag ataagggctg catgctgttc ctgtctttct 1578001 ttccgccgga ttgaaagttt tttattttaa gaggtaaaaa ggctatctgt atatcagcag 1578061 ccgcgaatca cattacatgg gaaaagacaa ccggcagaaa gctactgttt gtttgtctcc 1578121 gaaaggagga aagaagaaat gttaacgtat gataattggg aagaaccaac gattacattt 1578181 ccggaagacg atccttataa aggagcgctg tcagttttaa aatgggcata cggccattac 1578241 ggcgatcagc ttgtttatgc ctgcagtttc ggaattgagg gaatcgttct gattgactta 1578301 atttataaag tgaaaaaaga cgcagagatt gtgtttcttg atacaggact tcattttaaa 1578361 gaaacctatg aaacaattga acgagtgaaa gagcgttatc cgggtcttaa tatcatcctg 1578421 aaaaaaccag atctcaccct tgaggaacaa gccgaagaac atggtgacaa actatgggaa 1578481 agagagccga atcagtgctg ctatcttaga aaggtcgttc ctttaagaga ggcgctttca 1578541 ggacatccag cctggctttc cggcctgcgc cgtgatcaag ggccaagccg tgccaatacg 1578601 aatttcttaa acaaagatga aaaattcaag tcagtaaaag tttgcccgct tatccattgg 1578661 acttggaaag acatttggag atatacatcc cggaatgaac tggactacaa tccgcttcat 1578721 gaccaaggct atccaagtat tggctgtgcg ccttgcactt ctcccgcttt tacagcagaa 1578781 gatttgcgct caggcagatg gaatggtatg gcgaaaacag aatgcggact gcatgaataa 1578841 ggagctgcaa aatggaatta gccgctattt tatttagctt gtttttcgcg atgaatattg 1578901 gtgcaagcgg cgctgcagct tcgatggggg ttgcttacgg ctccggagcc atcaaaaaga 1578961 aaacttacgc tttgatccta tgcgcagtcg gtgtctttgc cggggcggtc attggcggag 1579021 gcgaggttgt aaaaacaatc agctccggca ttattcctga gcagacgatt acactgacga 1579081 ttgtttgcat cattattgga gctgctgccc tgtcgctctt tactgctaat ctgctcggca 1579141 ttcctttgtc gacaagtgaa gtaacagtcg gcgcggttgt cggcgtggga gtggcttata 1579201 aagtattgtt tgtgaacaat cttctgatca ttgtgtcatt ttgggttttt gtcccgctgt 1579261 tcgctttcgg cttcacctat ttcgtatcta agctgtttcg ttattttaag attgaagtaa 1579321 aatcttctaa aaagcaaaaa atcctcggca ttgttttgtt agttgccgga tttttcgaag 1579381 cattctctgc cggcatgaat aacgtggcga atgctgttgg cccgttagta gctgccggtg 1579441 tgcttgatgt cggaaaagga accttgtatg gaggagcttt tgttgctctt ggcgcactgt 1579501 tattaggccg gcgagtgcta gaaacaaacg ggaagaaaat tacgaggttc tccaaagggg 1579561 aaggcattct cttatccggt acaggagcgg gactggtgat catcagttct gtatttggga 1579621 tgccggtgcc cttggcgcaa gtcacgtcat cgtctattat cggaataggc atggcgaaaa 1579681 acggtccgaa cgtgttccat aaacaagttg ttcaaacgat gctgaaggta tggatcgtat 1579741 cgccgttttt atctttatcg atttcttatc tgcttgtatc cttgttttta aaagcagatt 1579801 attattcgat ctttatcatg gtaagtgtgc ttttagcggc gggcggtgcc atcagcctga 1579861 caaaggccat tcgtaaagag agacgctcag tccacgaaca aggcggggga atctgatcat 1579921 taatctgagt aattttataa gttaactagg aggagatgga tattatgagc ttagcaccac 1579981 acggaggaac attagtaaac agagtagatg aatcatatga tgtgagcggc attcaaaaag 1580041 aaattgaact tgatttaatt tctttcgcgg atttggaatt gatcggtatc ggtgcataca 1580101 gcccgattga aggtttcttt aatgaaaaag attacgtatc agtggtcgaa aacatgcgtc 1580161 tttcttccgg cgttgtctgg tctcttccaa tcacgcttcc ggtcgatgcg caaaaagcag 1580221 cggaactgtc acttggtgaa acggtaaagt taacgtatga aggagaaact tacggcgtta 1580281 tccaaatcga agacctgtac gtgcctgaca aacaaaaaga agctgtcaat gtgtacaaaa 1580341 cagatgaaca ggagcatcct ggtgttaaaa agctgttcag ccgcggcaat acatatgtcg 1580401 gcggaccgat tacgttgatt aaaaaagctt caaaacagtt ccctgaattt acatttgaac 1580461 cgtcagaaac gagacgccag tttgcggaaa aaggctggga aaccattgtc ggtttccaaa 1580521 caagaaaccc tgttcacaga gcgcatgaat acattcaaaa aacggctctt gaaacagtag 1580581 acggcttgtt cttgaatccg ttagtaggtg aaacaaaatc tgatgacatt ccagctgatg 1580641 tacggatgga aagctaccaa gtgcttcttg atcattatta cccgaaagat cgtgttttcc 1580701 ttggtgtctt tttagcggcg atgcgttatg caggcccgag agaagcaatt ttccacgcgc 1580761 ttgtcagaaa gaactacggc tgcacacatt tcatcgtcgg ccgtgatcat gcaggtgtag 1580821 gcgactatta cggaacatac gaagcacagg aactgtttga cacatttaaa cctgaagaac 1580881 tcggaattac accgctgaaa tttgagcaca gcttcttctg taaaaaatgc ggaaatatgg 1580941 gaacagcaaa aacttgccct catggcagag agcatcacgt cattttatca ggcactaagg 1581001 taagaggtat gctgagagac ggtgtgctgc cgcctgctga attcagtcga aaagaagtag 1581061 tagaagtgtt aatcaaaggg atgaagaaaa aagaagaagt aggcgtatct taaggaggac 1581121 tggcagtgac aaatcgcgat attgtatggc atgaagcctc tatcacaaaa gaagagtatc 1581181 agcaaaaaaa caagcataaa agctccattc tctggctgac agggttaagc ggctcaggca 1581241 aatcaaccat tgccaacgcc gctgcgagag aattgtttga gcaaggctac caagtcattg 1581301 tgctggacgg ggataatatc cgtcacggcc taaataggga tcttggtttt tctgatgaag 1581361 accgaaaaga aaacatccgc cggatcggag aggtggcgaa gctttttgtt cagcagggaa 1581421 ccattgtgat tactgctttt atctctcctt tccgcgagga cagacaacag gttcgcgagc 1581481 ttgtggaagc gggcgaattt aatgaagtct acattaaatg cgaccttgat atttgtgaac 1581541 aaagagatcc gaaagggctt tacaaaaaag caagaaacgg cgagattccg ttctttacag 1581601 gaattgattc tccttatgaa gaaccggaag ctccagagct cgttcttgat tcaggacagc 1581661 atgaccgtga agcgtgtaaa aatcagctga tcgagtttgt taaacaaaaa ttgagctgaa 1581721 tatgatctgc tgcgttcttc tcagatgccg gaatgcaagc gagaacatca tcacagcgaa 1581781 tcttctggaa gaactcgaat agatcggggg aaatacgatg gggaaagtat atattgtagg 1581841 agcgggtccc ggtgaccctg atctgctgac aattaaagcg ctgaaagcca ttgaaaaagc 1581901 tgatgtcatc ttatatgaca gattagtaaa taaagagatt ttacaatatg ccaaagagca 1581961 agcagacctg atctactgcg ggaagcttcc ggattttcat acgatgaagc aggaaaccat 1582021 caatcgattt cttgtgaagt atgcgcaaaa agggaaaatg gttgtcagac tgaaaggcgg 1582081 agaccctttt gtgttcggga gaggagggga agaagcggaa tgcctctctg aaaatggaat 1582141 tccgtttgaa atcattcccg gcattacgtc tggaatcgcg gcagccgctt atgccgggat 1582201 tcctgttacc catcgggatg cgggctctaa cgtcgctttt gtaacgggtc actataaaaa 1582261 agaagaagat tttgaggaaa agtggaaagc gctggctaca ggaattgata cacttgtcat 1582321 ctatatgggt atcaaaaacg tgcagcagat tgaaagaaaa ctccttgaaa atggccggga 1582381 cggttctacg ccagcagcct ttattcattg ggggacaacg gacaagcaaa aatctgtttt 1582441 ttgtacagtt gacacccttt cagaaacggt gataaaagaa aacattacaa atccgagttt 1582501 aattgtcatt ggaaatgttg taaattatca ctataagctg gaatggtttg aatctgaact 1582561 aaaaaaacaa gatttaagcg aggcgttgta aaaatgaaac aagcaatttt atatgtcggc 1582621 cacggcagcc gggtcaaaaa agcgcagcaa gaagccgcag cctttttgga aggatgcaag 1582681 gcccacatct ctgtgccagt acaagaaatc agctttttag agcttcagga gccgacaatt 1582741 gagacaggat ttgaagcatg tgtgaagcaa ggtgccactc atatcgcagt ggtgcctctg 1582801 cttcttttaa cagctgcgca tgcaaaacat gatattccgg aagaaattgt ccgtgttgca 1582861 tctcgatatc catcagtccg tatttcatac ggaaagccga tcgggattga cgaagaagta 1582921 gtcaaggctg tatatcaccg aatgaaagac ataggtgttc cgtatgaaaa tgccagagtg 1582981 gtgctcatcg gaaggggaag ttcagatcca gacgtcaaaa gagacgtaac cggaattgct 1583041 aatcttcttc aggaaatggt tccagtgaag gaagtcattc cgtgcttttt gacagcatgc 1583101 ggccctaatt acaaagaggt tttttcagaa cttgaaaaag atgacggcat aacaaccttt 1583161 atcgttccat atttgctttt tacgggtatg ctgatgaatg aaatcgaacg agaggttcag 1583221 aaattaaaag cccataatcc gaacgtctac ctctcttcct atatcggttt tcatcctcat 1583281 gtgaaaaacg catttttgaa ccgtgtgaga gaaactgcgg caaattctga gggacaattt 1583341 gattttgatg gaggttcata tgcttccgct gcacattagc ctggaaaaga agaaggttgt 1583401 gattgcgggg ggcggaagca tcgctctcag aaggctgaaa acggtgattt ctgagggagc 1583461 tgatataacg cttgtcagtc cggatgtgga accggaaatc aagcaaatgg cagaagagcg 1583521 gcgtatcaaa tgggaaaaac ggacaattga aaaagaagat tatctcaatg ctttcttcat 1583581 tattgctgcg acggataatg cggcagtgaa caaagaaatt gcccaatccg cttcgccttt 1583641 tcagcttgtc aattgtgtca gtgacgctga gcttggcaat gtatatatgc cgaaaatcgt 1583701 aaaaagaggg catgtcactg tgtctgtttc tacaagcgga gccagtccaa agcacacgaa 1583761 agagcttgct gaaaacgtgg ataagctgat tgacggcgat tttgttgctg aagtgaacag 1583821 gctttatcag atgagaagaa agaaataagc cagagcatac aaatgctctg gcttttcttt 1583881 atgcggctca gctttttttg agcttgatga cagtatcagc atcaggcgtg acaaagacgg 1583941 tatgctggct gtcataagtg acgaaaccgg gtttcgcgcc gtttggtttt ttgacatgcc 1584001 tgatttttgt ataatctaca ggcactgaac ttgaatcttt agcttttgaa aaataagctg 1584061 caattgtcgc ggcttccatg attgtttgct catcaggttc gctgcttctg atcacaacgt 1584121 gggagccggg aatgtccttc gtgtgaagcc agatatcgtc tctggccgcc actcttgtcg 1584181 ttaaatattc attttgacga ttgttcttac ccactaaaat tgtcagccct gaggtggatt 1584241 catatgtttc taacaccgga ttgtgcggtt tttgcttttt ctggcctttt tgctgcttag 1584301 ggcgtaaata tttgccctca acaagctctt ccctgatttc gctgatatcc cggggagaag 1584361 cggacgaaag ctgctgaatc agctgatcaa aatattcgat ctcttcctgt gccagcctga 1584421 tttgctcctc gacaactgcg accgaatttt tcgctttctg atacttcgtg aaataggcct 1584481 gtgcgttttc agaaggcgtt ttgttcgggt ttaaaggaat cgtgattgtc gggctttctt 1584541 catcataata attgatgacc tcagcctgtt tatcaccttt tttcagcata tataaattag 1584601 cggttaaaag ctctccgtaa agctgaaatt ccttcgcgtt ttccgaatac tccagggttt 1584661 tctctaattt tttgattttg ttggcattct tcttccgttc gttcacaaca aaacgctcaa 1584721 gatcctgagc ctgttgctta acccggtctc gttcagcttt tccgaaataa aaacggtcga 1584781 gcagttcgct taatgaatca aaacggcgcg cttcgccctt tagatgagtc agctccagca 1584841 gataaaaata ttcctttccg tttacagtcg taatgttggg aatgaaacgg tgctctttca 1584901 cttcggcaaa cagtgccagc aacgcttttg gcagtgtgac tttgttggca aggcctgctc 1584961 tgtgaaccgc ttctttggcg aaaagcggag acacgcctga aaagtggtcg acaatttgtt 1585021 tatcaagcct tccttcttga aagctgaggt gacgcaaaat atcatcttct gacgcctcaa 1585081 gaggcgatat tttgtcctga gcaggcggaa gcttataatc ttggccgggc agtactgtac 1585141 ggtagctgtt cattgacggt gataaatgct taagtccgtc gataatcaca ttttctgctg 1585201 cgtcagtcaa aatgatattg ctgtggcggc ccataatttc tacataaagc tttcgtacgg 1585261 tttcatcgcc aatttcgttt cggcttttga tatgaaaaat cataatgcgg tctaagcccg 1585321 cttgttcaat tttctcaatg aatccgcctt cgatatgctt tctcagcaac atgcaaaaca 1585381 ttggcggttc gcttggattt tcataagctt gtgccgtgat atgcacccgt gaatagctcg 1585441 gatgtgccga taataatagt ttttggtttt ttcccttggc acggatgtgg aaaatcacat 1585501 cgtgcttata tggctgatgg atttttgtaa ttcgtccgcc cattattttc tcgttaagtt 1585561 cgtgtgtcat tccgtatgta aacatgccat caaacgacat atgcaataca ccctctcatt 1585621 cttcctgcat tcgataatta tagcatgaaa tgggacgagt cagaataagc atgcttatag 1585681 agtgatatct ctataagaga gcaggggagt ggacgagcgg aatgaagttt catgaaatgg 1585741 gacaaacaga tttactagag gcaaccaata cgtccatgaa acaaggatta acagaaaaag 1585801 aggtaaaaaa acgccttgac aagcatggac caaacgagct gcaagaaggg aaaaaaactt 1585861 cagcgcttct cttgtttttc gcgcagttca aagattttat ggtgcttgtg cttctggcgg 1585921 caacgttaat ctcaggattt cttggtgaat atgtagatgc ggttgcgatt attgcgattg 1585981 tgtttgtgaa tggcatactc ggtttctttc aagaaaggcg tgctgagcaa tctcttcagg 1586041 ctttaaaaga gctttcaaca ccgcacgtca tggcactcag ggaaggaagc tggacaaaga 1586101 ttccttctaa ggaactggtg ccgggtgata ttgtgaaatt tacgagcggg gacagaattg 1586161 gcgcagacgt tcgaattgtt gaagcgagaa gccttgaaat agaagaatca gcgctaaccg 1586221 gggaatcaat cccggttgtg aagcatgctg ataaattgaa aaaaccggat gtttcactcg 1586281 gcgatattac caatatggca tttatgggta cgattgtgac ccgcggcagc ggtgtcgggg 1586341 ttgtcgtcgg gacaggaatg aatacggcta tggggaaaat tgccgacatg cttgaatcgg 1586401 cagggacatt gtcaaccccg ctgcaaagaa gactggagca gctcgggaag attttgattg 1586461 ttgttgcatt gcttctgacc gtacttgtcg ttgctgtcgg tgttattcag ggtcatgatc 1586521 tgtacagtat gtttttagca ggtgtctcgt tagcggtagc cgctattccg gaggggctgc 1586581 cggcgattgt gacagtggcg ctttcgcttg gtgtacagag gatgattaaa caaaaatcca 1586641 ttgttagaaa gcttcctgct gttgaaacgc ttgggtgtgc gtctatcatt tgctcagata 1586701 aaacagggac aatgacccaa aacaaaatga cagtgacgca tgtctggtcc ggagggaaaa 1586761 catggagagt ggcaggggcc ggctatgaac cgaaaggaag cttcacacta aacgaaaaag 1586821 agatcagtgt caatgaacat aagccgcttc agcagatgct tctgttcgga gcgctttgta 1586881 acaactccaa tattgagaaa agagacggcg aatatgtgct tgacggagat ccgacagagg 1586941 gagcgctgct caccgcggca agaaaaggcg gtttttcaaa ggagtttgtt gaatctaatt 1587001 acagagtgat tgaagaattt ccgtttgatt ccgcacggaa aatgatgact gtcatcgtag 1587061 agaatcaaga cagaaagcgc tatatcatta caaaaggtgc gccggatgta ctcatgcagc 1587121 gatcttcccg tatttattat gatggctcag cggctctttt ttcaaatgaa agaaaagcag 1587181 aaacagaggc ggtattaaga catttggcat cacaggcgct cagaacgata gcggtcgcct 1587241 acaggccgat aaaagcaggc gaaacaccgt caatggagca ggcggaaaaa gatctgacca 1587301 tgcttggcct ttcaggtatc attgatcccc cgcggccgga agtcagacag gcgattaaag 1587361 aatgccgtga agcgggaatt aagaccgtca tgattacagg tgatcatgta gaaaccgcta 1587421 aagcgatagc gaaagacttg cgcctccttc cgaaaagcgg caaaatcatg gacggcaaga 1587481 tgctgaatga actttctcaa gaagagcttt ctcatgtggt ggaggatgtg tatgtatttg 1587541 cccgcgtttc ccctgaacat aaactaaaaa tcgtaaaagc ctatcaggag aacgggcata 1587601 ttgtggcgat gacgggagac ggcgtcaatg atgctcctgc cattaaacag gctgatatcg 1587661 gcgtctctat gggcattacc gggacagatg tggccaaaga agcatcatct cttgttctcg 1587721 tggatgataa ttttgcgacg attaaatcag cgataaaaga aggcaggaac atctacgaaa 1587781 atatcaggaa gtttatcaga tacctgttgg cgtctaacgt cggagaaatc cttgtcatgc 1587841 tgtttgcgat gctgcttgcc cttcctttac cgctggttcc gattcagatt ttgtgggtca 1587901 acttggtgac ggacggattg ccggcaatgg cgctcggcat ggatcagccg gaaggagacg 1587961 tcatgaagcg caagccccgt catccgaaag aaggggtatt tgcccgcaag ctaggatgga 1588021 aggtcgtttc cagaggattt ttaatcggag ttgccactat tttagcgttt atcattgtgt 1588081 accaccgcaa tccggaaaac ttggcttatg cccagacgat cgcgtttgcc acattggtgc 1588141 tcgctcagct tattcacgtg tttgactgcc gcagcgaaac ttctgttttc tctagaaatc 1588201 cgtttcaaaa cctgtattta atcggcgcgg tattgtcatc cattttgctg atgcttgtag 1588261 taatctacta tccgccgctt cagccgattt tccatactgt agccatcacg ccgggggact 1588321 ggatgctcgt catcggtatg tccgccatcc ctactttttt gctggcgggg tcacttttaa 1588381 caagaaaaaa ataaattcat atgatataat cttaggggta atagcgtgtc tattgccctt 1588441 ttattatgag aacagggaag aattgggtgt tttaaaatga tacgaagtat gacaggcttc 1588501 ggcagtgcaa gcaaaacaca agacgatctc tctgtaagcg ttgaacttaa atctgtgaac 1588561 tacagattta aagaagtgaa cgctcgtttg ccaaggcctt tgctatattt tgaagataag 1588621 ctgaaacaga ccattctgca gcatattcag cgcggaagaa ttgagctttt cgtatccgtt 1588681 gacagcgata tgcttgttga gaaaaggctt gaaattgatt ggccgctgct cgatgagttt 1588741 gtcgcagccg cgagagatat gaagaagcgg tatcaattgt ctgcagagcc cgatgtaatg 1588801 gatttcttta agcttgatca tgtcgtccag gttcatgaag aacagacgca aaatgacaag 1588861 ctggaggcgt tgatcatcga tgctgcagaa gaagcggtaa aaggtctctg tgaaatgcgt 1588921 gaaaaagagg ggctgctctt agcgaaagac tgcctgatgc atattgatca gcttgaagag 1588981 ctggtgagag aaactgaatt gctggctgca gatgtcgtat ctcgttaccg ggaacggctg 1589041 tatgccagaa tcaaagaatg gactgaagac gtattagacg agagccggct tgtaacagaa 1589101 tgcgctattt ttgcagaccg ctctgatatc actgaagaga ttacaaggct gaagagccac 1589161 ttcgcccagt ttcgtgatat attagctagt ggcggagctg tcgggcgcaa actcgacttt 1589221 cttgttcagg agctcaatcg ggaagcaaat acgatcggct caaaagcaaa tgatcatcag 1589281 atcacaaagc ttgtcgttga aatgaaaagt tctattgaaa aaataaaaga acaagtgcaa 1589341 aatatagaat agtgactgtg cgtattgttt acagacggtc ttactaggct aaactagaga 1589401 cgtctatttt acagggggaa cgtagaagat gacgattaaa ctgattaata tcggatttgg 1589461 caatatcatc tccgccaatc ggatgatttc gattgtcagc ccggagtctg cgccaatcaa 1589521 acggatgatt caggatgcaa gagaccgcgg aatgctaatt gacgctacat acggacgaag 1589581 aacccgtgca gttgtcgtca tggatagtga tcacattatc ttatctgccg tccagcctga 1589641 gacagttgca cacagacttt ctgttaaaga agaaattatg gatgaagggc aggggtaatt 1589701 gccgcatgaa agaaagaggg ttattaatcg ttctctcagg tccctcagga gttggtaaag 1589761 gaacggttcg acaagcgatc ttttcgcagg aagacacaaa atttgaatat tcgatttcag 1589821 taaccacaag aagtccaaga gagggcgaag tgaacggagt cgattatttt ttcaaaacaa 1589881 gagacgaatt cgagcaaatg attgcggaca acaagctgct tgaatgggca gagtatgtcg 1589941 gcaattatta cggcacgcca gtcgattatg ttgaacagac gcttcaagat ggaaaagacg 1590001 tctttttaga aattgaagtt caaggggctc ttcaagtgag aaatgctttc ccggaaggcc 1590061 tgtttatttt ccttgcgcct ccaagccttt ctgaactgaa aaacagaatc gtgacacgag 1590121 gaacagaaac agacgctctg attgaaaatc gaatgaaagc cgcaaaagct gagatcgaaa 1590181 tgatggatgc ttatgactat gtcgttgaaa acgataatgt cgaaacggct tgcgataaaa 1590241 tcaaagcaat cgttcttgct gaacatttga agcgtgaacg cgttgcacca agatataaga 1590301 aaatgctgga ggttgaataa tcaatgttag atccgtcaat tgattcttta atgaataaat 1590361 tagattcaaa atatacgctg gtgactgttt ctgcgagacg tgcccgtgaa atgcaaatca 1590421 aaaaagacca aatgattgaa catacgattt cacacaaata tgtaggcaaa gctttagaag 1590481 aaattgatgc aggcctgctt tcgtttgaaa aggaagaccg cgaatagtag cacaagtagc 1590541 aacctatatc atgtaggttg ttattttttt ccgtgcggtt ttgtaaagtg cagaggggga 1590601 gaattcattg cttaacaatc gaaatgtgtt actttgcgtg agtggaggca tcgctgttta 1590661 taaagcctgt gcgttaacga gcaagctggt tcaggcagga gcaaatgtca aagtgattat 1590721 gactgaatcc gcttgccgat tcgtttcacc gctgacattt caggcattga gccgccacga 1590781 agtctataca gatacattta aagaacaaaa tccaagcgtc atttctcata ttgatgccgc 1590841 agactgggcc gacttgatta tcgtagcgcc ggctacggct aatgtgattg gaaaactggc 1590901 aaacggcatc gctgatgata tgctgacgac aacattgttg gcagcaacgg ctcccgtttg 1590961 gatcgcgccg gcaatgaacg ttcatatgta tgaccacccg gcagtcaaac gaaacatttc 1591021 tgttctttat caggacggtt attgttttat tgagccaagt gagggctatt tagcatgcgg 1591081 ttacgtagga aaaggcagat tggaagagcc ggaaaacatc gtaaagctgg ccgaaaaaca 1591141 ttttgctgaa gaaacatccg ctcctttaga aggcaagcat gtggtcatta cagccggccc 1591201 aacgcgggaa gcgattgatc ctgtccggtt ttttaccaat aaatcgacgg gcaaaatggg 1591261 ctacgcactg gcggaggctg ctgttcagct cggcgcacgg gtaatcttaa tttctgggcc 1591321 tgtttcactt gatcagccta aaggccttgc tgagtttatc cctgttcaat cggctgcgga 1591381 tatgcgcgaa gctgtgctct ctgtgtatga cgcaagcgat atagtcatta aaacagctgc 1591441 ggtagccgat tttacgccga aaacagtatt tgaccataaa atgaaaaaac aagacggcgg 1591501 catgacctta gaactgaaaa gaacagtcga tattttgaaa gaattgggcg agaaaaagaa 1591561 agagcagatt ttggtcggat ttgccgccga aacacaagac attgaacact atgcacgtaa 1591621 aaagctcgcc gctaaaaacc ttgatttgat tgtggcaaat gatgtgaaag caaatggggc 1591681 cggttttggt gctgatacga atatcgtgac aatctttttc aaagacgggc ataaacgcga 1591741 actcccgatt atgtctaagc tcgatgtttc ttttgaaatc cttcaggaga tcgcagccct 1591801 ctcaaaacaa accggagagc gctcatgaat tttgcagaag tcatcgttga tgtcagcacc 1591861 aaaaatatag acaggccttt tgattataaa atcccagacc atctgaaggg catgatcaaa 1591921 acggggatgc gggtcattgt tccgtttggc ccccgtaaga ttcaagggtt tgtgacagca 1591981 gtcaaagaag catctgacct atcgggaaaa tctgtcaagg aagtagagga tttattagat 1592041 cttacacctg ttctgacaga ggagcttatg attctgtcat catggctgtc agacaaaacg 1592101 ctgtctttta aaataacggc gcttcaagca atgctgcctg ccgccttaaa ggcgaaatat 1592161 gaaaaagaat taaaaattgc acacggagcc gatcttccgc cgcaagtgga acggctgttt 1592221 tctgaaacaa agacgctgct gtattcagat atacccgatc atgagacgct gaaactgatt 1592281 caaaggcatg ttcaaaaagg ggacattgac gtgacgtata aagtcgcgca aaaaaccaat 1592341 aaaaaaatgg tcaggcatat tcaggcaaat gcgagtaaag aagagcttgc taagcaggct 1592401 gagggattgt cccgccaagc agcaaaacag caggcgattc ttcactttct catctctgag 1592461 ccggaaggtg tgaaaattcc tgcggcggaa ttgtgcaaaa aaacggacac gagctctgca 1592521 accatcaaaa cccttatcca aaaagggctt ttgaaggaaa gctatgaaga ggtttacaga 1592581 gatccctatc aggacaaaat gttcaaaaaa acagagcccc tgccgctgac agacgaacag 1592641 agggctgcct tcgagcccat acgcgagaca ttggacagcg atgagcataa agtgttcctc 1592701 cttcacggcg tgacaggaag cggaaaaacc gaaatttatc tgcaatcaat tgaaaaagta 1592761 ctggcgaaag gaaaagaagc catcgtcctc gtaccggaaa tatcgctgac gccgcaaatg 1592821 gtcaaccgct tcaagggccg cttcggctcc caggtggcag tcatgcacag cggtttatcc 1592881 acaggagaaa aatatgacga gtggcgtaaa atccaccgga aggaagtacg gcttgtcgtc 1592941 ggtgccagat ccgccatttt tgctccgttt gaaaatctcg gaatgataat catcgatgaa 1593001 gagcacgagt cttcctataa acaggaagaa atgccgcgct atcatgcgaa agaggtggca 1593061 atcaagcggg ctgagcatca cagctgcccg gttgtattag ggagtgctac gccgacatta 1593121 gaatcatatg ctagagcgca aaagggcgta tacgagcttc tttcactgaa gcaccgtgtt 1593181 aaccatcggg tgatgcccga ggtttcgctt gtcgatatga gagaggagct tagaaacggc 1593241 aatcgctcga tgttttcagt tgaattgatg gaaaagcttg aagaaacgat tgccaagggt 1593301 gagcaggcgg tgctgttttt aaataagagg ggctactctt cctttgtgat gtgcagggat 1593361 tgcggctatg tcccgcaatg cccgcactgc gacatttcca tgacgtatca tcgttacggc 1593421 caaaggctga aatgccatta ttgcggacat gaagagcctg ttccgcacac ttgtcctgaa 1593481 tgcgcaagcg agcatatccg ctttttcgga acgggaacac agcgagtgga ggaagagctg 1593541 acaaaagtgc tgccaagtgc gagagtgatt cggatggatg ttgacacgac atcacggaaa 1593601 ggcgcccatg aaaaattact gtcagctttc ggagaaggaa aagcggatat tcttctcgga 1593661 acgcaaatga tcgcgaaagg gcttgatttt ccgaatgtca cgcttgtcgg agtgttaagt 1593721 gctgatacaa cacttcatat tcctgatttc agatcggctg aaaaaacatt tcagctgtta 1593781 acgcaagtca gcggccgggc aggcaggcat gaaaagcccg gccatgtcat cattcaaacg 1593841 tatacaccgt ctcattacag tatccagctg acgaaaacac acgattatga aacgttctat 1593901 cagcatgaaa tggcgcacag gagagagcaa tcctatccgc catactacta tttggctctt 1593961 gtgactgttt ctcatgagga agtggcgaaa gcagcggtta cagctgaaaa aatcgctcat 1594021 tttttgaaag caaactgcgg agctgacacg aaaattctcg gaccaagcgc gtcgccgata 1594081 gccaggatca aagatagata tcgctatcaa tgcgtgataa aatacaaaca ggaaacccag 1594141 ttatccgctt tattgaagaa gatactggaa cattataaac gcgaaattga acaaaaacat 1594201 gtaatgattt caattgatat gaatccttat atgatgatgt aagatctcac gtcttggagg 1594261 gtaacaaatt ggcagtaaaa aaggtcgtca cacatcctgc ggaggttttg gaaacacctg 1594321 cggaaaccgt gactgttttt gataaaaagc taaaaaaact gcttgatgat atgtacgaca 1594381 ccatgcttga aatggatggt gtcggactgg cagcgccgca aatcggcatt ttaaaaagag 1594441 cggccgtcgt agaaatcggg gatgacagag ggagaattga tctcgttaat cctgaaattt 1594501 tagaaaaaag cggcgagcaa accggaattg aaggatgctt gagctttcct aacgtctatg 1594561 gtgatgtcac acgtgccgat tatgtcaaag tgcgtgcgtt taaccgtcag ggaaaaccgt 1594621 tcattctgga agcgcgaggc tttttagcaa gagccgtgca gcatgaaatg gaccacttag 1594681 acggtgtgct gtttacatct aaaataagta aatactatac agaagatgaa ctagcggata 1594741 tggaaggatg atttgatgac gagaatcgta tttatgggaa cgccggattt ttcagttcct 1594801 gttttaagaa ccctgataga ggacggatat gaagtagtgg gggtcgtcac acagccggac 1594861 cgtccgaagg gcagaaaaaa agtactgaca cctcctccgg taaaggaaga ggcattgcgc 1594921 cacggcatcc cggttcttca gccggaaaaa gtcagattga cagaagaaat tgaaaaagtg 1594981 ctggcattaa agcctgacct gattgtaacg gcggcattcg gacaaatttt gcctaaagag 1595041 cttctcgaca gtccaaaata cggctgcatt aacgttcacg catccctttt gccggaactg 1595101 cgcggcggtg ctccgatcca ttattccatt ctgcagggaa agaagaaaac cgggattacc 1595161 attatgtata tggtagaaaa attggatgcg ggcgatatga tctcaaaagt ggaagtggac 1595221 attgaagaaa ccgacaatgt cggaacactg cacgataaat taagcgttgc tggcgcgaag 1595281 ctattgtctg aaacggttcc aaacgttatt gccggcagca tatcacctga aaagcaggat 1595341 gaagagaaag cgacgtacgc gcctaacatt aaaagagagc aagagctgct cgactggtcc 1595401 agaacgggcg aagagcttta caaccagatc cgcggcttaa atccatggcc tgttgcttat 1595461 acgactctaa acggacaaaa cttgaaaata tgggcgtcga aaaaaatagc ggcaccaaca 1595521 acagctgagc ccggcacagt cgttgcagtt gaaaaggaag gaattatcgt tgccacaggt 1595581 aacgagacgg ctctgttatt aaccgaactc cagccggcag gcaaaaaacg aatgaaaggc 1595641 gaagactttg tgcgaggcgc tcatgttgaa gccggtgatg tgttaggagt aaacaatgaa 1595701 aaaaactagt gttcgtgaca tcgcccttga ggcgctgatc aaattagaac aaaaccaggc 1595761 atacagcaac ctgctgctga aatcggtcat taaatcaaat gaactgagtg atcagaacag 1595821 agggcttttg actgaacttg tctatggtac attacaaaat aagatcgcgc ttgattatat 1595881 gcttaaaccg tttatcaata agcctcaaaa ggtaaagccg tgggtgattc agcttcttcg 1595941 cctatcctta tatcaaatgg agtatttgga gaagattcca gacagggcag ccattcatga 1596001 agcggttgag attgctaaaa tccgcggaca caaaggcatt gcttcatttg tcaacggcgt 1596061 gctccgttct attcagcgcg aaggtgttcc atcctttgac gcgatcgaag atcctgtccg 1596121 ccggctggcg acagaaacaa gccatccgga atggcttgtg aaagagtggg cggatgcgta 1596181 tggatttgaa gctgcggaaa agatttgccg catccatctc attccgccga aacagacgct 1596241 gcgtgtcaat caaatgaaag cagacagagc tgagctgctt gaccaaatgg ctgctgaggg 1596301 aatcgaagtt gaaaaaggcg acctcgctga agatgctgtg aagctcttaa agggaacaat 1596361 tgccggaact catttcttcc aaaacggcga agtttctatc caggatgaga gctccatgct 1596421 cgtcgcccgc gcccttgatc ctaagtcaga tgaaacagtg cttgacgcgt gtgcggcgcc 1596481 tggcggaaag tcggctcata tcgcagaatt aatgaagaac aaggggagcg ttacgtcgct 1596541 tgatcttcac aaacataaag tgaagctgat caaagaagcg gcagatcggc ttggcctgac 1596601 aatcattcat gcggaaacaa tggatgctag aaaagcgggg gaaacgtttg aaaacgaaca 1596661 gtttgaccga atattggtcg atgccccgtg ctcaggtttc ggtgttatca gaagaaagcc 1596721 ggacatgaaa tacacgaaaa aacctgacga cagcgcccgt ctagctgaaa tccagctgtc 1596781 gatcttgagg gaaatcgcac cattagtaaa aaaaggtggc actcttgtct acagtacgtg 1596841 tacaatggac cggacagaaa atgatgaagt aatacatgcg tttatacaag aacatcctga 1596901 ttttgaaccc gatttgtctc ttgaaaagcg gctgcctgaa aaggtgagac cctttgttcg 1596961 ggatggaagg cttcaaatcc ttcctcatta tttcggaaca gatggtttct ttatttgcag 1597021 catgagaaag aagggataag caatggcaga acttaataaa acaaaagtaa gaaaagaatt 1597081 gcggacagag cgtccgtcta tttattcttt tgaattagat gaaatcaaac aatggctgac 1597141 agacaatgga gagaaaccgt tccgtgcagc ccagatcttt gaatggctat atgaaaaacg 1597201 cgtatcttct tttgaagata tgacaaacct ctcaaaggat ctgcgtgaga aattaaacac 1597261 tcgctttgtg ttaacaacgc tgaaaacggc tgttaaacaa acctctcaag acggtacgat 1597321 gaagtttttg tttgagcttc atgacggtta taccatcgaa accgttttaa tgagacacga 1597381 gtatggcaat tctgtatgtg taacgacaca agtcggctgc cgtattggct gcacattctg 1597441 cgcgtcaacg cttggaggct taaaacgaaa ccttgaagca ggggaaattg tcgctcaagt 1597501 agtcaaagtg caaaaagctc ttgatgaaac ggatgaacgc gtcagctctg tcgtgatcat 1597561 gggaatcggc gaaccttttg ataactttaa cgaaatgctc gctttcttga aaatcattaa 1597621 ccatgacaag ggcctgaata tcggtgctcg ccatattacg gtctctacga gtggaatcat 1597681 cccgaaaatt tacgaatttg ctgatcagca aatgcagatt aactttgcaa tttctctgca 1597741 cgcgccgaac acagaaatca gaagccgttt gatgccgatt aacagagcat ataaactgcc 1597801 tgatctaatg gaagccgtta aatattatat taataaaaca ggacgccgta tcagctttga 1597861 atacgggctg ttcggaggcg taaacgacca ggtggaacac gccgaagagc ttgccgactt 1597921 gctggaagga gtcaaatgcc acgtgaactt gattccggta aactacgtgc ctgaacggga 1597981 ctatgtgcgc acaccgcgtg atcagatttt tgcttttgaa aaaacgctga aatcccgcgg 1598041 agtaaatgtc acaatccgaa gagagcaagg acatgacatt gacgcagcct gcggtcagct 1598101 tcgcgcgaag gagcgtcaag acgagacgag gtgatgaggg ttgttaacag ccttaaaaac 1598161 agatacagga aaaatccgcc agcataatga agatgatgcg gggatattca aggggaaaga 1598221 tgaatttata ttagcggttg tcgctgatgg catgggcggc catcttgctg gagatgttgc 1598281 gagcaagatg gctgtgaaag ccatggggga gaaatggaat gaagcagaga cgattccaac 1598341 tgcgccctcg gaatgtgaaa aatggctcat tgaacagatt ctatcggtaa acagcaaaat 1598401 atacgatcac gctcaagccc acgaagaatg ccaaggcatg gggacgacga ttgtatgtgc 1598461 actttttacg gggaaaacgg tttctgttgc ccatatcgga gacagcagat gctatttgct 1598521 tcaggacgat gatttcgttc aagtgacaga agaccattcg cttgtaaatg aactggttcg 1598581 cactggagag atttccagag aagacgctga acatcatccg cgaaaaaatg tgttgacgaa 1598641 ggcgcttgga acagaccagt tagtcagtat tgacacccgt tcctttgata tagaacccgg 1598701 agacaaactg cttctatgtt ctgacggact gacaaataaa gtggaaggca ctgagttaaa 1598761 agacatcctg caaagcgatt cagctcctca ggaaaaagta aacctgcttg tggacaaagc 1598821 caatcagaat ggcggagaag acaacattac agcagttttg cttgagcttg ctttacaagt 1598881 tgaagagggt gaagatcagt gctaatcggc aagcggatca gcgggcgtta ccaaattctc 1598941 cgcgtcatag gcggcggggg aatggccaac gtgtatttag ctgaggatat cattctagac 1599001 cgtgaagtcg caattaaaat cctgcggttt gactatgcaa atgacaatga atttatcaga 1599061 cgtttccgca gagaagccca atccgcatca agcctcgatc acccgaatat tgtcagcatt 1599121 tatgatttgg gcgaggaaga tgatatttat tatattgtca tggaatacgt tgaaggcatg 1599181 acgcttaaag aatacataac agcaaatggg ccgcttcacc ctaaagaagc gctgaacatc 1599241 atggagcaaa ttgtctcagc catcgctcat gcccatcaaa accagattgt tcacagagac 1599301 atcaagccgc ataacatttt gattgatcat atgggaaata tcaaagtaac ggattttgga 1599361 attgcgacgg cactaagttc gaccacaatc acccatacca attcagttct gggctcggtc 1599421 cattacttat cacctgaaca ggcccggggc ggcttagcca caaaaaaatc ggatatttat 1599481 gcgcttggaa tcgttctatt tgagctttta accggccgta ttccgtttga tggagagtca 1599541 gcagtcagca tcgccttgaa gcatcttcaa gcggaaactc cttcggcaaa aaggtggaat 1599601 ccatcggtcc cccaaagcgt tgaaaacatc atactcaagg caactgccaa agatcctttt 1599661 catcgctacg aaacggctga agacatggaa gcagacataa aaacagcttt tgatgccgac 1599721 agactcaatg aaaagagatt tacgattcaa gaagatgaag aaatgacaaa agcgatacct 1599781 atcattaaag atgaagaact tgctaaagct gctggcgaaa aagaagctga agtgacaacc 1599841 gcacaagaaa acaaaacaaa gaagaacggc aaaagaaaaa agtggccgtg ggttttgctc 1599901 acgatatgcc tcgtttttat cacagctgga attcttgctg tcactgtttt tccgtcgctt 1599961 ttcatgccta aggatgtcaa aatacctgat gtctccggaa tggaatacga aaaagccgca 1600021 gggctcttgg aaaaagaagg tttacaggtt gattccgagg tgttggaaat ctcagatgaa 1600081 aaaattgaag agggcctgat ggtaaaaacg gatcctaaag cggataccac agtcaaagaa 1600141 ggcgccacgg tcacccttta taagagcacc ggaaaagcaa aaacggagat cggtgatgtg 1600201 acaggccaaa cggtcgacca agcaaaaaaa gcgttgaagg accaagggtt taatcatgta 1600261 acagtaaatg aagtgaatga cgagaaaaat gcgggcactg tcattgacca aaatccttca 1600321 gcagggactg agctggtccc gagtgaagat caagtcaaac ttacagtcag tatcggaccc 1600381 gaagacatta cgcttagaga cttgaaaacc tacagtaaag aagcagcgtc tggatatctg 1600441 gaagacaacg gattgaagct tgtagaaaaa gaagcatact cagatgatgt tccagaagga 1600501 caggttgtca aacaaaaacc agcagcaggt acggcagtaa agccgggaaa cgaagttgaa 1600561 gtgacattct ctctcggacc agagaaaaaa cctgcgaaaa cagtgaaaga aaaggtcaag 1600621 atcccctacg aaccagaaaa tgaaggggac gagcttcaag tgcaaatcgc ggttgacgat 1600681 gcggatcaca gcatctctga cacttacgaa gaatttaaga taaaagagcc gactgaacga 1600741 acgatcgaac taaagattga accaggccaa aaagggtact atcaagtaat ggtaaacaat 1600801 aaagttgtca gctacaaaac cattgagtat ccgaaagatg aataacaagg agggaaaata 1600861 tgcctgaggg caaaattatt aaggcgctaa gcggctttta ctatgtactg gatgaatcag 1600921 aggattcaga taaagtaata caatgcagag gaagaggcat tttcagaaaa aacaaaatta 1600981 cccctcttgt cggtgattac gttgtgtatc aagctgaaaa tgacaaagaa ggatatctaa 1601041 tggaaattaa agaaagaacc aacgagctta tcaggccgcc aatttgcaac gttgatcaag 1601101 cggtccttgt tttctcagcg gttcagcctt ctttcagcac ggcattgctc gaccgcttcc 1601161 tggttctcgt tgaggccaat gatattcagc cgattatatg cattactaaa atggatctga 1601221 ttgaagatca agatacagaa gatacgatac aagcctatgc agaagactat cggaatattg 1601281 gttatgacgt ataccttacc tcctctaagg accaagatag tttagcggac atcatcccgc 1601341 attttcagga taaaacaacg gtatttgccg gtcagtccgg tgttgggaaa tcctcgcttc 1601401 tcaacgcgat cagtccggag ctcggattaa gaacaaacga gatttccgag catttgggcc 1601461 gcgggaaaca cacaacccgc cacgtggagc tgattcacac gtccggaggt ttggttgcag 1601521 atacaccggg attcagctcg cttgaattta cagacattga ggaagaagag ctgggctata 1601581 ccttccctga tatcagagaa aaaagctctt catgcaaatt tagaggctgt ttacatctga 1601641 aagagccgaa atgtgcggtg aaacaagctg ttgaagacgg ggaattaaag cagtatcgct 1601701 atgaccatta tgttgaattt atgacggaga ttaaagacag aaagccgagg tattagcata 1601761 atgataaagg ttgcaccatc tattctttcc gctgattttg ccgctttagg caatgagatt 1601821 aaagatgtag aaaaaggcgg agccgattgt attcatattg atgttatgga cggccatttt 1601881 gtcccgaata tcacaatcgg tccgctgatt gtagaagcgg tccggccggt aacggatctg 1601941 ccgcttgatg tccatttaat gatagaagag ccggatcgtt atatcccggc ttttgcgaaa 1602001 gcaggcgcag atatcctgtc tgtgcatgct gaggcatgtc cgcacctgca ccgtaccatc 1602061 cagctcatta aagagcaagg agtgaaggcc ggagtagttc taaacccgca tacccctgta 1602121 caagtcatcg aacatgtttt cgacgatctt gatcttgttc ttttaatgac ggtgaacccg 1602181 ggcttcggcg ggcagaaatt tattcattca gtccttccta aaataaaaga ggttaagcga 1602241 atggcggatg aaaaaggaaa aaaagatctg ttaattgaag tagacggcgg cgtcaacaaa 1602301 gaaaccgctc cgctcgtcat tgaagcgggc gcaaatttac tcgttgccgg ttcagctgtt 1602361 tatggccagt ctgaccgcaa aaaagcaatt tctgaaatca gaggaagtaa ataagcagct 1602421 ttagaaaaga gctgggcata caatagccta agctcttttt cctgtatgca gagaaaggaa 1602481 tcagagatga aaacaattaa tatcgttgcg ggaggcccga aaaatctcat tcccgatcta 1602541 accggctata cggatgaaca cacgctttgg atcggtgttg acaaaggcac cgtcactctc 1602601 ttagatgccg ggatcattcc tgttgaagcc ttcggagatt ttgacagcat aacggagcaa 1602661 gaacgccggc gaatagaaaa agccgctccc gcccttcatg tgtatcaagc agaaaaagat 1602721 caaacagatt tagacctcgc ccttgattgg gcgctggaaa agcagccgga tattattcag 1602781 attttcggca ttacaggcgg cagagctgat cattttttag gaaacattca gcttctgtat 1602841 aaaggtgtaa aaacgaacat aaaaattagg ctgatagaca aacaaaatca tattcaaatg 1602901 ttccctcctg gtgaatatga tattgagaag gatgaaaata agcgatatat ctccttcata 1602961 ccgttttccg aagacataca tgagctgacc ctgaccggtt ttaaatatcc tctaaataat 1603021 tgtcatatta cgctcggttc aacactatgt attagtaacg aactcattca ttcacgaggt 1603081 actttttcgt ttgcaaaagg catattaata atgataagaa gcacggatta agcatgtgct 1603141 ttcattcaat tgctgaaaac aatgaacaag gcggttacgg gacgttatag gaggggacaa 1603201 aaatgaaatt ttacaccatt aaattgccga agtttttagg aggaattgtc cgggcgatgc 1603261 tgggctcatt tagaaaagat taatgcccag gggttcaaag ccctctttca ccacataaaa 1603321 acgcctgcca catatcgggg caggcgttca ttttgttata cacgctcaac tttaccggat 1603381 ttcaaagctc gagcagatac atatactttt ttaggttttc cgttcacaag gatacgaacc 1603441 ttttgaagat tcgcgcccca agtgcgctta gaagcgttca ttgcgtgaga acggttattc 1603501 ccagctgttg tttttttacc tgtgataacg catttacgtg ccatttgttt ccctcctcac 1603561 ttgcacaaaa catctacttt ttaacattca tataatctta gatgctttcg atatggatac 1603621 tttaaataat ttaccacagc taaaaaacgt ttgcaactat tgtttcatca tctttcaaga 1603681 aaattcactt gacatcttgc ggaaacagca gcgctatagt atatgtagag gtacggccag 1603741 cgattattgc ctggtctttt cataatggaa accatatagt agaatagctg taactctatg 1603801 cattcgaagg aggaactagt gtgtccattg aattaagaac gaagtacgga cagattgata 1603861 tatctaatga agtcatcgcg atggttgcag gaggcgcggc ggttgactgt tacggcattg 1603921 tcggcatggc ctctaaaaac cagattaaag acggactgac tgaaatcctt cggaaagaga 1603981 atttcagcag gggtgtccaa gttcgccaag aaggagaaca gatacatatc gacatgtata 1604041 tcattgtcag ctacggcacg aaaatttctg aagtggcaca taatgtccaa acaaaagtaa 1604101 agtacacagt aaatcaaacc atcggactgg cagtggattc tgtcaatatt tatgtccaag 1604161 gcgtacgagt gacgaacccg tagttaggag gagtaggatt gtctatcaga acattagacg 1604221 gcagaacctt tgccgagatg attcttgcgg gagcgcagaa tctgtctcaa aacgccagtg 1604281 cagttgatgc actgaacgtg ttcccggtgc cggacggtga tacgggaaca aatatgaacc 1604341 tgtcgatgac ttccggagca agagaagttg aacaaatgga tacggatgat atcgggaagg 1604401 tgggctccgc gttatctaaa gggctgctca tgggagcacg cggaaattca ggagttatcc 1604461 tatcccaatt gttccgcgga tttagcaaaa acattgaaac gaaaaaagaa attaatgcac 1604521 ttgagtttgc cgctgcgctg caagcaggtg tagacatggc gtataaagct gtcatgaaac 1604581 ctgtagaggg caccatttta acagttgcaa aagacgctgc aaaaaaagca atgatcttag 1604641 cagaaaaaga aaccgatatc actgcgctga tgactgcagt gacagaagaa gcagaggcgt 1604701 ctttaaaccg cacccctgaa ttgctacctg tcctaaagga agtaggagtt gtcgatagcg 1604761 ggggcaaagg cctgctctgt gtgtatgaag gtttccttgc ttcattaaaa ggtgaaactg 1604821 tacctcagaa agcagttctt ccgtcacttg acgacatggt cagcgcagag catcacaaga 1604881 gcgcgcaaag catgatgaat accgaagata ttgaatttgg attctgtacc gaagtgatgg 1604941 ttaggcttga tcagacaaaa agagagttcg acgaaggcac gttcaggcaa gacctcagcc 1605001 agttcggaga ttctctgctt gtgattgcgg atgaatcgct ggcgaaggtt catattcatg 1605061 ctgaagagcc gggaaacgtg ttaaactacg cccagcatta cggtgaattg atcaaaataa 1605121 aaatagaaaa tatgagagaa cagcatacct ctatcatcag tcaagaaagc aaacctgcag 1605181 acaacgaaac accgccggca aaacagccgt atggcattgt gactgtagcg atgggagaag 1605241 gaattgcaga cctatttaaa agcattggcg cttctgttgt gattgaaggc ggccagacca 1605301 tgaacccaag cactgaggat attgttgatg ccgtgaagtc tgtaaatgca gatacggtat 1605361 ttatcctgcc taacaactcc aacattatca tggctgctaa ccaagcggcc agcgtagtgg 1605421 atgaacaggt ttttgtcatt cctgctaaaa cggttccgca agggatgtca gctctgctgg 1605481 cttttaaccc ggatcaagaa gctgaagcga acgaggccaa tatgctaagc gccattcagc 1605541 aagtaaaaag cggacaggtg acgttctcag tcagagatac tcatattgac ggtaaagaca 1605601 ttaaaaaagg cgactttatg ggcattctga atggaacgat tatcggcact tctgaaaatc 1605661 agctgtcagc cgcgaaaatg ctgctgtcag aaatgatcgg agaagatgat gaaatcgtga 1605721 ccattctata tggtgaggat gcgtctcagg aagaagctga gcagcttgaa gcgtttctca 1605781 gtgaaaagta cgaggagatt gaggttgaga tccacaatgg gaaacagcct ctgtattcgt 1605841 atatagtttc agcagaatag aagggcaatt tgcccttcta ttcttatgtc tgcttttaag 1605901 tgcggcagcg ctgtaacgcg cccgcttgcc attttatatc tgatcaatta gtctagaagc 1605961 aaagcgctaa taagctctgg ttcataagga ggaatagcat gaaatacaga agcgtttttg 1606021 atattatcgg cccggttatg atcggtccgt ccagctctca tacagcggga gctgctagaa 1606081 tcgggagagt ggccagaagt ttatttggca gagagcctga gcgcatcatt gtatcttttt 1606141 acggctcgtt tgcggaaacg tataagggcc acggcacaga tgtcgcgatt atcggcggat 1606201 tgcttgattt tgatacattc gatgaacgga ttaaaaccgc tatacaaatt gcagaagcta 1606261 aaggaattga tatagagttt cgggtagaag acgcagtccc ggtccacccg aacacagcaa 1606321 aaatcaccat ttctgatgaa aagggtgagc tggaactgac gggtatttcg attggcggag 1606381 gaaagattga aatcacagaa ttgaatggtt ttgagctccg gctgtcagga aatcatccgg 1606441 ccatattagt tgttcataat gacaagtttg gcacaattgc cggtgttgcc aatgttctgg 1606501 cgaaattttc aatcaacgta ggacatatgg aagtagcccg gaaagatatc ggccagcttg 1606561 cgctgatgac aatagaggtc gatcaaaata ttgacgacca cattctcgac gagctgtcga 1606621 agctgccgaa tattattcaa gtgacaaaga ttgctgacta gcgaaaaggg tcaggaggag 1606681 ccagttatgt ttcgtaatgt aaaagaatta attgagatta ctaaagaaaa acaaatattg 1606741 atctctgatg tgatgatagc tcaagagatg gaagtaacag aaaaaacaaa agaggacatt 1606801 tttcagcaga tggatcataa cctgtctgtt atggaagcgg cggttcagaa aggactcgag 1606861 ggagttacga gccaaacggg cttaacaggc ggagatgccg ttaaattgca ggcctatatt 1606921 cgatcaggaa aaagcctgtc tggcccgctg attttagatg ctgtatcgaa agccgttgca 1606981 acaaatgaag taaatgcagc catgggaacc atctgtgcga caccgactgc aggttctgcc 1607041 ggtgtggtgc ccggtacgtt atttgctgta aaagaaaagc tgaatccaac aagagaacaa 1607101 atgatccgct ttttgtttac agccggggct ttcggatttg tcgtggccaa taacgcaagc 1607161 atttccggcg ccgccggagg atgtcaggca gaggttggat cagcttcagg catggcggct 1607221 gcggctattg ttgaaatggc aggaggaaca cccgaacaaa gcgcggaagc catggccatt 1607281 acattaaaaa atatgctagg cctcgtgtgc gaccctgttg cagggcttgt tgaggtgcct 1607341 tgcgtgaaac ggaatgcgat gggcgcgtca aatgcgatga ttgctgctga tatggcattg 1607401 gcgggcatta caagccgtat tccatgtgat gaggttatcg atgccatgta taaaataggc 1607461 caaacgatgc caactgcact tagagaaaca ggccagggcg gtttagcggc aacaccgaca 1607521 ggaagagaat tagagaaaaa aattttcgga ggagcgctag gttcacgtga aacaacatca 1607581 gcaaactagt atagctaaca ttaagggtat tgggccggaa acagaaaaaa cattgaatga 1607641 actcggtatt tatgacattt ctgatcttct gaattatttc ccttatcgct atgatgacta 1607701 cgagctgagg gatttagaag aagtaaagca tgatgaaaga gtcacagtcg aagggaaggt 1607761 tcattcagag ccttctctta cctattacgg aaaaaaacga aacaggctga cattcaggct 1607821 tctggtcggc cactatttaa tcacagccgt atgttttaac cggccttatt tgaagaagaa 1607881 gctttcgctc ggctctgtgg tgacggtttc aggtaaatgg gacaagcacc gccaaaccat 1607941 ctctgttcag gagttgaaaa acgggccgca tcaagaagac aaaagcattg aaccagtgta 1608001 ttctgtgaaa gaaaatgtta ccgtcaaaat gatgaggcgc tttattcagc aggcgctgac 1608061 ccaatatgca gactcacttc ctgatcctct tccggaaaag ctaagaaaaa gctataaact 1608121 gcctgactat tatcaagcgt taaaagcaat gcaccagcct gaaacaaggg aagcattaaa 1608181 gcttgccaga cggcggtttg tttatgaaga atttttgttg tttcagttga aaatgcaggc 1608241 gttccgaaag gcggaaagag agcagacaca agggatacgg cagcgttttt caaacgaaga 1608301 actcatgaga tttatcaaaa gcctcccgtt tcccctcaca aacgcccagt cacgcgttct 1608361 tcgcgaaata acagcagaca tgtcttctcc atacagaatg aaccgtcttc ttcaagggga 1608421 cgttggatca ggaaaaacgg cagtcgccgc cattgcactg tatgccgcga tcctatccgg 1608481 ataccaagga gcgctcatgg tgccgacaga aattctggcc gagcagcatg ctgattcgct 1608541 cgtttcgcta tttgaaaaat gggacgtcag cgttgctctt ttgacaagct ctgttaaagg 1608601 aaagcggcga aaagaactgc ttgagcgtct tgcggcgggt gagattgata ttcttgtagg 1608661 aacccatgct ttaatccaag acgaggtgga gtttaaggcg ttgagtctcg ttattactga 1608721 tgaacagcac agatttggag ttgagcagcg caaaaagctt cggaacaaag ggcaggatcc 1608781 cgatgttctc tttatgacag ccactccaat cccaagaaca ttagcgatca cagtattcgg 1608841 tgaaatggat gtatctgtca ttgatgagat gccggctgga cgaaagcgaa ttgaaaccta 1608901 ttgggtaaaa catgacatgc ttgatcgtat tttggcattt gtcgaaaaag aattaaagca 1608961 aggcaggcag gcttatatca tctgtccgct gattgaagaa tcagataagc ttgatgtgca 1609021 aaacgccatt gacgtgtaca atatgctttc tgatattttt cggggaaaat ggaatgtcgg 1609081 ccttatgcat ggaaagctgc attccgatga aaaagatcag gtcatgagag aattcagcgc 1609141 aaatcactgt caaattctcg tatcaaccac tgttgtggag gttggcgtaa atgttccgaa 1609201 tgcaacaatt atggtgattt atgacgccga ccgtttcgga ctatcacagc ttcaccagct 1609261 gcgcggccgt gttggacggg gtgagcatca atctttctgt attctgatgg ctgatccaaa 1609321 atcagaaaca gggaaagaac ggatgaggat catgtcggag accaatgacg gtttcgagct 1609381 gtctgaaaag gatctggaac tgagaggtcc cggtgatttc ttcgggaaaa aacaaagcgg 1609441 aatgccggaa tttaaagtgg cggacatggt tcatgattac agagcgcttg aaacggcaag 1609501 gcaggatgct gcgaatcttg tggcttctga cgcgttctgg aaggagccgg aatacgctgt 1609561 gttaagagat gaattgctga agagcggagt aatggacggg gaaaaattaa gctgagtatc 1609621 agaagttttt ggtgttcagc cagaaacaat cgttgcattc caatctatga aattatatac 1609681 tactattagt acctagtctt aattgtccgg atggtgttta gatatgagaa gaaataagag 1609741 agaacgccag gaattacttc agcagacgat tcaagcaacc ccctttatta cagatgaaga 1609801 actagcgggt aaattcgggg tgagcatcca gacgatacgt ttggaccgct tagagctttc 1609861 catacctgaa ctgagagaaa gaattaagaa cgtggcagag aaaacacttg aggacgaagt 1609921 gaagtccctg tcacttgatg aagttatcgg agaaattatt gaccttgagc tggatgatca 1609981 ggcgatatcc attttagaaa taaaacagga gcacgtgttc agccggaatc agattgcgag 1610041 aggacaccat ttatttgcac aggcgaattc tttggccgtt gcagtcattg atgacgagct 1610101 ggcgctgact gcaagtgcag acatccgctt tacaagacag gtaaagcagg gtgaacgtgt 1610161 cgtagcaaaa gcgaaagtga cggctgtcga aaaagaaaaa ggaagaacgg ttgtcgaagt 1610221 gaacagctac gttggcgaag aaattgtttt ttctggacgc tttgacatgt atcgttcaaa 1610281 acattcataa aggtggagca tgcatgagaa tagctgtaga tgcaatggga ggagaccacg 1610341 ctcccaaagc tgttattgac ggagttataa aaggtataga ggcatttgat gatctccata 1610401 tcacacttgt cggtgacaaa acaacgatag aatcacattt aacaactaca tcagatcgca 1610461 tcacggtgct gcacgcagat gaagtgattg agcctacgga tgaaccggtc cgtgccgtgc 1610521 gaagaaaaaa gaactcatct atggttctta tggcgcagga ggttgcggaa aacagagctg 1610581 acgcctgcat ttcagcggga aataccggtg cattaatgac agccggtctc tttattgtcg 1610641 ggagaattaa aggaattgac cgtccggcgc ttgctccgac acttccgact gtttcgggag 1610701 acggatttct tctccttgat gtcggcgcca atgtcgatgc caaaccggag cacctcgttc 1610761 aatatgccat catgggttct gtttattctc agcaagtgcg cggtgtcact tcaccgagag 1610821 tcggactttt aaatgtcgga acagaagata aaaaaggaaa cgaactgacg aagcagacgt 1610881 ttcaaatttt aaaagaaaca gcaaacatca attttatcgg aaacgtggaa gcgcgagacc 1610941 ttttagatga tgtggcggat gttgtagtaa cagacggctt taccgggaat gttacactca 1611001 aaacgctgga aggctctgcg ttgtcaattt ttaaaatgat gagagacgta atgacgtcta 1611061 ctttgacatc caagcttgca gcagctgtgc tgaaaccaaa attgaaagaa atgaaaatga 1611121 aaatggagta ttcgaattat ggcggagcaa gtctttttgg cttaaaagcg cctgtgatca 1611181 aggcgcacgg ctcttcagat tcaaatgctg tattccatgc gattcggcaa gcaagagaga 1611241 tggtcagcca aaatgtggct gcgctcattc aggaagaagt gaaagaagaa aaaacagatg 1611301 agtagtctgg aggtttttac atcatgagta agattgcatt tttattcccg ggtcagggat 1611361 cacaatttat cggcatggga aaagagcttt atgagcaggt gcctgctgca aagcgtctgt 1611421 ttgatgaagc cgatgaaacg ttggaaacaa aactcagctc gcttattttt gagggggatg 1611481 ctgaagaatt aacacttaca tacaatgcgc agcctgcttt gcttacgaca agcatcgctg 1611541 ttcttgagaa atttaaagaa tctggcatta cacctgattt cacagcagga cacagccttg 1611601 gtgaatattc tgcactggtt gcggctggcg ctctgtcttt caaagatgct gtttatactg 1611661 tcagaaagcg cggagagttt atgaatgaag cggtgccggc tggcgaagga gcaatggctg 1611721 cgattctcgg catggatgct gaagcattaa agcaagtaac cgataaagtc acagaggaag 1611781 gcaaccttgt acagcttgcg aatctcaact gtcctggcca aatcgtcatt tccggaacag 1611841 ctaaaggggt tgagcttgca tctgaactgg caaaagagaa cggcgcaaaa cgcgcaattc 1611901 cgcttgaagt aagcggtccg ttccattctg aactgatgaa accggctgct gaaaagctga 1611961 aagaggtatt ggacgcctgt gacataaaag acgctgacgt tccggtcatc tcaaatgttt 1612021 ctgctgacgt gatgactgaa aaagcagata tcaaagaaaa acttattgag cagctttact 1612081 ctccggttcg ttttgaggaa agcattaaca agctgatcgc agagggtgtt acgactttta 1612141 ttgaaatcgg tcccggaaaa gtgctttcag gccttgtgaa aaaagtgaat agacggttaa 1612201 aaacaattgc tgtatcagat ccggaaacga tcgagctggc aattcaaacg cttaaggagg 1612261 agaatgataa tgcttaatga taaaacggct attgtcactg gcgcatcccg cggaatcggc 1612321 cgctcaatcg cccttgatct ggcaaaaagc ggagcaaatg ttgtcgtgaa ctactccggc 1612381 aatgaagcga aagcaaatga agtggtagat gaaatcaaat caatgggcag aaaagcaatt 1612441 gctgtaaaag cggatgtatc aaatcccgaa gatgtacaaa acatgataaa agaaacattg 1612501 tctgtttttt ctacgattga cattctggtt aataatgcgg gaattacaag agacaatctc 1612561 atcatgagaa tgaaagaaga cgaatgggat gacgtcatta acattaacct gaagggtgtt 1612621 ttcaactgca caaaagctgt tacaagacaa atgatgaaac agcgttcagg ccgcattatt 1612681 aacgtatcgt ctatcgtcgg cgtcagcgga aaccctggac aagccaacta cgtggctgca 1612741 aaagccggcg tcatcggttt aaccaaatct tctgctaaag agctcgccag ccgaaatatt 1612801 acggtaaacg caatagcgcc aggatttatc tcaactgata tgacagataa acttgcaaaa 1612861 gacgttcaag acgaaatgct gaaacaaatt ccgctcgcgc gctttggtga acctagcgat 1612921 gtcagcagtg ttgtcacgtt cctagcttca gagggagctc gttatatgac aggccaaacg 1612981 cttcatattg acggcggaat ggtgatgtaa gttttttctc gaaaatttca tcgtagtttc 1613041 tctagttttt taaaaacgaa tccactataa tacttgaggg gaggtgaatt gctatggcag 1613101 acacattaga gcgtgtaacg aaaatcatcg tagatcgcct tggcgttgat gaagcagacg 1613161 tcaaacttga agcttctttc aaggaagact taggtgctga ttccctagat gtagttgagc 1613221 ttgttatgga acttgaagac gagtttgata tggagatttc tgacgaagat gctgaaaaga 1613281 ttgcaacagt cggcgacgct gtgaactaca tacaaaacca gcaataagct gatgctaaaa 1613341 gtcccgccga aacgcggggc tttagccctt tattcgtgca gttattacag catgccgctt 1613401 ttacgcgcgc tgtatccggt ttagtcagag aagcgcggtg aacctgatgt gcctatggag 1613461 gttactatgt caaaacactc acattataaa gataaaaaaa agttctataa aaaagtagaa 1613521 caatttaaag agtttcaaga acggatttcg gttcactttc aaaatgaaaa gcttttgtat 1613581 caagcattta cacattcatc ttatgtgaat gagcatcgga aaaagccgta tgaagataat 1613641 gaaaggcttg aatttttagg tgacgctgtt ttggaactga cgatctccag attcttattt 1613701 gccaaatacc cggctatgag tgaaggagat ttgacgaaat tgagagccgc aattgtttgc 1613761 gaaccgtctc tcgtttcatt ggctcacgag ctgtcattcg gcgatcttgt cctgttgggt 1613821 aaaggcgagg aaatgacagg cggaagaaag cgtcctgctc tattggcgga tgtttttgag 1613881 gcatttatcg gagccttgta ccttgaccaa ggattagagc cggtcgaaag tttcttaaaa 1613941 gtttatgtgt tccctaaaat taacgatggt gctttttctc atgtgatgga tttcaaaagc 1614001 cagctgcagg aatacgtgca gcgggacggc aaaggctctc tggagtataa aatctccaac 1614061 gaaaaaggac ctgcgcacaa ccgtgaattt gaagccatcg tatctctaaa aggtgaacca 1614121 ctcggagtcg gaaacggccg ttcaaagaaa gaagccgaac agcacgctgc tcaggaagct 1614181 ttagctaaat tgcaaaaaca ccatacgaaa caataaaatc ccccttatga ctcaggggga 1614241 tttcagtatg tatgccgtct tatttgacca atgtttatga tagaattgaa atacttatta 1614301 cataaggagg atcgctatgt tcctcaaacg tttagacgtt ataggattta aatcatttgc 1614361 agaacggatt tccgtagact tcgttaaagg cgtgacagca gttgtcgggc cgaacggaag 1614421 cggaaaaagc aacatcacgg atgccattcg ctgggttctc ggcgaacaat cggcacgctc 1614481 tcttcgcggc ggaaaaatgg aagacatcat ttttgctggg agtgattcaa gaaagcgatt 1614541 aaatctagct gaagttacgc ttactcttga taatgatgat catttcttgc caattgactt 1614601 ccacgaggtg agtgtcacaa gacgtgtgta cagatcaggt gagagtgagt ttctgattaa 1614661 caatcagcca tgccgcttga aagatattat tgatttattt atggactctg ggcttggtaa 1614721 agaagcattt tctattatca gccaagggaa agtggaagag atcctgagca gcaaagcgga 1614781 ggatcgccgc agtatctttg aagaagcggc cggggtgctt aaatataaaa cgagaaagaa 1614841 aaaagcagaa aataaactgt ttgagacaca ggacaatcta aatcgggtag aagatatatt 1614901 acatgagctt gaaggacagg ttgaacctct taaaattcaa gcttcaatag cgaaagacta 1614961 ccttgagaaa aagaaagagc tggagcatgt tgaaattgcg ctgactgcct atgatatcga 1615021 agagctgcat ggtaaatggt cgactcttaa agagaaagtg cagatggcaa aagaagaaga 1615081 gcttgctgaa tcgtctgcta tttctgcgaa agaagcaaag attgaggata caagggacaa 1615141 aatacaagcg cttgatgagt cagtagatga gctccagcaa gttttactgg taactagtga 1615201 agagctggaa aagcttgaag gccgtaaaga agtcctgaaa gaacgaaaga aaaacgctgt 1615261 gcaaaaccaa gaacagcttg aagaagccat cgttcagttc cagcaaaaag aaacggttct 1615321 gaaagaagag ctttcgaagc aggaagctgt cttcgaaacg cttcaggctg aggtgaagca 1615381 gttaagggcg caagtaaaag aaaaacagca ggctctcagt cttcacaatg aaaatgtcga 1615441 agagaaaatc gagcagctga aaagtgatta ttttgagctg ttaaacagcc aggcttcgat 1615501 acgcaacgaa ctccagcttc ttgatgacca gatgtcccaa tccgctgtca cattgcagag 1615561 acttgcggac aacaatgaaa agcacctgca ggaacggcat gatatttctg cgcgtaaagc 1615621 cgcatgtgaa acggaatttg cccgaattga gcaggagatt cacagtcaag tcggtgcata 1615681 tcgtgatatg cagacaaaat atgagcagaa aaagcgccaa tacgaaaaaa atgaatccgc 1615741 tctgtatcag gcataccaat acgttcagca agcgagatca aaaaaggaca tgcttgagac 1615801 gatgcaggga gatttctccg gcttttatca aggtgttaaa gaagtgctga aagcgaaaga 1615861 gcgccttggc ggaattcgcg gagcggttct tgagctgatt tctacagaac agaagtatga 1615921 aacggccatt gaaatagcgc tcggcgcttc tgctcaacac gtcgtgaccg acgatgaaca 1615981 atctgcccgc aaagcgattc aatatttaaa gcagaattcc ttcggccggg cgacgtttct 1616041 gcctctttct gttattagag accgccagct tcaaagccgt gacgcggaaa cagccgcccg 1616101 gcattcatca tttctcgggg ttgccagtga acttgtcaca tttgatcctg cgtatcgaag 1616161 cgtcatccag aatcttcttg gaaccgttct gatcacagag gacttaaagg gtgcaaacga 1616221 gcttgcgaag cttctcgggc accggtaccg catcgtaacc cttgagggag atgttgtgaa 1616281 ccccggtggt tcaatgacgg gcggcgcggt taaaaagaaa aataactccc tccttggaag 1616341 aagccgggag ctagaagatg tgacgaaacg gctcgctgaa atggaagaga aaacggcact 1616401 gcttgaacaa gaggtcaaaa cccttaagca ctccattcag gatatggaga aaaaactggc 1616461 tgacttaaga gaaaccgggg aaggcttaag gttaaagcag caggatgtga aaggccagct 1616521 gtacgaactt caagttgccg agaaaaatat caatacccat ttagagctct atgatcaaga 1616581 aaaatctgct ctgtcagaaa gcgatgaaga gagaaaagtg cgcaaacgca agcttgaaga 1616641 agagctctct gccgtatctg aaaagatgaa acagcttgaa gaggacatag acagactgac 1616701 aaaacaaaaa caaacgcaat cctcaacgaa agagtctctc tccaacgagc tgactgagct 1616761 gaagatcgca gcggccaaaa aagagcaggc ttgcaagggg gaagaggaca accttgccag 1616821 attaaagaaa gagctcactg aaacagagct tgcgttaaaa gaagcaaaag aagacttaag 1616881 cttcttaacg tcagagatgt catctagcac cagcggcgaa gaaaagctgg aagaagcagc 1616941 aaaacataaa ttgaatgaca aaacgaaaac gatcgaactg attgcattaa ggcgcgatca 1617001 gcgcatcaag cttcagcatg ggcttgatac gtatgagcgt gagctgaaag aaatgaaacg 1617061 cctgtataaa caaaaaacaa cgctcttaaa agacgaagaa gtcaaacttg gacgaatgga 1617121 agtcgagctt gataatttac tccaatactt acgggaggaa tacagcttgt cctttgaggg 1617181 ggcaaaagag aaatatcagc ttgaaactga tccagaggaa gccagaaagc gcgtgaagct 1617241 gattaaactc gcaattgaag agctgggtac cgtgaacctc ggaagcatag atgagtttga 1617301 gagggtcaac gaacggtaca agtttctgtc ggaacaaaaa gaagatttaa cagaagcgaa 1617361 aaataccttg ttccaagtga ttgaagaaat ggatgaagaa atgacgaagc gctttaacga 1617421 cacattcgtc caaatccgct cacactttga tcaagttttc cgctccttat tcggaggagg 1617481 gcgagctgaa ctgaggctca ccgatcctaa cgatctgctt cattcaggag tcgagattat 1617541 cgctcagccg ccggggaaaa agctgcaaaa cttaaacctc ctgtcaggcg gagagcgtgc 1617601 gcttactgct atagcgctct tattctcaat cctaaaggtt cgtccagtgc cgttttgcgt 1617661 ccttgacgaa gtagaggctg cgctcgacga agcgaatgtg ttccgatttg cgcagtattt 1617721 aaaaaaatac agcagcgata ctcagtttat tgtgattacc cacagaaaag gaacgatgga 1617781 ggaagcggat gtgctttatg gcgtaaccat gcaggaatcc ggtgtttcca aggtaatttc 1617841 agttaagctg gaagaaacaa aagaattcgt tcagtaacga ggaaagaggt taaaagatga 1617901 gcttttttaa aaaattaaaa gagaaaatca caaaacagac agattccgta tctgaaaagt 1617961 ttaaggatgg ccttgaaaaa acaagaaact cctttcaaaa caaagtgaat gatcttgtat 1618021 cccgttaccg taaagtggat gaggatttct tcgaagagct tgaagaggtt cttatcagcg 1618081 cggatgtcgg ttttacaacc gttatggaat taatagatga gctgaaaaaa gaagtcaaac 1618141 gcagaaatat tcaagatcca aaggaagtcc agtcagtgat ttctgagaaa ctggtcgaga 1618201 tttataacag cggagatgag caaatttcag aactgaacat ccaggatggg cgtttaaacg 1618261 taatccttct ggtaggtgta aacggcgtcg ggaaaacaac aacgatcgga aagcttgctc 1618321 ataaaatgaa acaagaagga aaatctgttg tacttgccgc cggagacact tttagagcgg 1618381 gagccattga acagctggaa gtatggggag agcgtacagg agtgcctgtc attaagcaga 1618441 cggcaggaag cgatccggcg gctgtcatct acgatgctgt tcatgctgcg aaagcaagaa 1618501 atgccgatgt attaatttgt gatacggcag ggcgtctcca aaacaaagta aatctcatga 1618561 aagagcttga aaaagtaaaa cgtgttatcg aaagagaagt tcctgaagct ccgcatgagg 1618621 tgctgcttgc ccttgatgcc acgaccggcc aaaatgcaat ggctcaggca aaagaattct 1618681 ctaaagcaac aaatgttacc ggcattgctt taacgaagct tgacggtacg gcaaaaggcg 1618741 gtatcgtcct tgcgattcgc aacgagcttc acatcccggt taaactagtc ggtttaggag 1618801 aaaaagttga tgaccttcag gaatttgatc cagaatccta tgtgtacgga ctcttttcag 1618861 atttagtgga aaaagccgac gattaagaaa aaggccccaa catcttgggg cctttttctt 1618921 ttttatcttc ttacttgata ggcgaaatga taaaggctgt tatcagtgga taccagtctt 1618981 gactcaccag aaaaaactct gaatgggatg atgtcatagt aatgaacgga aacagatgtg 1619041 taatacgtat agtaaccagc agctggcccc aaatacattg gaacctcaaa tgttccgttt 1619101 gcatcagtcg ttcctgaagc agtttgtgtt gtgtttccga ccttcgtgtc cgcttcaaat 1619161 cttacgggcg cgtttggcac tggctgtccg ttttggtcga gtaatttgcc gcttactgta 1619221 atattgtact tgactcgcca atattgacct tgtccgtaat tgattttacc gtatacccct 1619281 ccatctgtgc tgatatttgt gattgaggcc ttataaggtg cctcagcagc gtctgcttgc 1619341 tgtgccggga aacctattgt aaacagggct gccagacata acataaacaa taaaccgatt 1619401 tttttcataa aaatcctcct taaaataggg ttcatataca atatcggaat aaattggatg 1619461 atatttagcg tattttggaa aagttaatcg ccgctttgac aagataaaaa cttgacagtg 1619521 tcattaaaac cgtgtaaact aagttatcgt aaagggattt gacttaacaa aggggagagc 1619581 tcaaatgtca ctcgaaaaga caacgagaat gaattatctg tttgattttt atcagtcgtt 1619641 gttgacgtca aaacagaaga gctatatgtc gctttattat ttggacgatt tctccctagg 1619701 cgaaatagcc gaagaatatg aggtttcaag acaagctgtt tatgataaca tcaaacgaac 1619761 agaagcaatg cttgaacaat atgaagaaaa gctgctcctt ttgaaaaagt ttcaggagcg 1619821 taaagagatg tttaataagc tgaaggagct tgcttccggt tcaaaagaag aggaagaaat 1619881 tacagctctg attgaagcgc ttgagaaatt agattaggag gcggcaaact atggcatttg 1619941 aaggattagc cgaccgactg cagcagacga tttctaaaat ccgcggaaaa gggaaagtca 1620001 gcgaacaaga tgtaaaagag atgatgcgtg aggtccgtct tgcgctgctt gaggctgacg 1620061 ttaactttaa agtagtcaag gattttgtca aaaaagtaag tgaacgcgct gtaggccaag 1620121 acgtcatgaa aagtctgacg cccggccagc aggtcattaa agttgttcaa gaggaactga 1620181 ctgagctgat gggcggcgaa gagagcaaaa tcgccgtcgc aaaaaggccg ccgactgtta 1620241 ttatgatggt cggtctccaa ggtgccggta aaacgacaac aagcggtaag cttgcgaatc 1620301 tgctgcgcaa aaagcataat cgcaaaccga tgctggttgc tgccgatatt taccgcccag 1620361 ccgcaattaa gcagctggaa acactcggca aacagcttga tatgcctgtt ttctctcttg 1620421 gcgatcaggt cagtcctgta gaaatagcta aacaggctat tgagaaagcc aaggaagaac 1620481 attatgacta cgtcattttg gatacggcag ggcgcttgca tatcgaccat gaactgatgg 1620541 atgaactgac caacgtcaaa gaaatcgcga atccggaaga aattttcctg gttgtcgatt 1620601 caatgaccgg tcaggacgct gtgaatgttg ccaaaagctt taatgaacag ctcggtttaa 1620661 ccggtgttgt gttgactaag ctggatggag acacacgcgg cggggctgcg ctttctattc 1620721 gcgctgtcac aaacacgcca attaagtttg caggtttggg cgaaaagctt gatgcgttag 1620781 agccgttcca tcctgaacgc atggcatcaa ggattctcgg catgggcgac gtgctgacat 1620841 tgattgaaaa agcacaggcc agcgttgatg aagacaaagc caaagagctg gaacaaaaaa 1620901 tgagaacgat gagcttcaca ttggacgatt ttctggagca gctcgggcaa gtcagaaaca 1620961 tggggccgct tgatgagctt ctgcaaatga tgccgggtgc aggtaaaatg aagggcctga 1621021 aaaacatcca agttgatgaa aaacagctga atcatgtgga agcaatcatc aaatcaatga 1621081 ctgttcttga aaaagaacag ccggatatta tcaatgccag ccggcggaag cggattgcaa 1621141 aaggaagcgg gacatccgta caggaagtca accgtctgct taagcagttt gatgaaatga 1621201 aaaaaatgat gaagcagatg acaaacatgt caaaaggcaa gaaaaaaggg tttaagctac 1621261 cttttatgta atcggttata catgataaaa ccgttgttaa gaaaaaacac tttacaaaca 1621321 cttttatcat tgttaatata ctatcttgtt gaaatatttt cggaggtgct agtaaaatgg 1621381 cagtaaaaat tcgtttaaaa cgtatgggag caaaaaaatc tcctttctat cgtattgttg 1621441 tagcagattc tcgttcacca cgtgacggcc gtttcatcga aacagtcgga acttacaacc 1621501 cggttgcaaa accagcggaa gtaaaaattg acgaagagct tgctcttaaa tggcttcaaa 1621561 ctggagcgaa accatctgat acagttcgca acttgttctc tagccaagga atcatggaaa 1621621 aattccacaa cgctaaacaa ggcaagtaat gactgatcaa cacttggaag atttgattgt 1621681 ccacattgtg acgccgcttg ttgatcatcc agatgacatt cgcgtcataa gagaagaaac 1621741 cgatcaaaag attgcgctgc gcttatctgt ccataagtca gataccggta aagttatcgg 1621801 aaagcaaggc cggactgcaa aagcgattcg aacagctgta tttgcagctg gcgtacagtc 1621861 ttctaagaaa gttcaatttg aaatatttga ctaaaaggga gagggccggc acctcccctt 1621921 tttttacacg caaaaaaagg gtaaactgat agaagcttag gcaaaataga aaagcctgga 1621981 cgagtaaaag ttttaaaagc ggggagcttg gtgcgatgca aattattcac cgtgtagccg 1622041 ttatgcaagt cttaaccgag cgcagtaaag aaaagctttt agcttctttt gctgagaaga 1622101 aacaaatgct tgaacgagaa tgcagccagc tctattttca gcttagaaaa catgagaaag 1622161 aacagcaaaa ccctaatatg attgaacaat ttaaaaaggc aatagaaaag cgaaaagatg 1622221 atataaaaat cattgatttt caaattgctc aagtacatac attgccgctt ggcagtgagt 1622281 tgaaagaaaa ggaagtcgat gcgctgctga cgattgaagc cggggatgac tggcatgaga 1622341 aaacagcagc gaacaccatc gtcataaaag acggaaaagt aattgaaatt cgccagaggt 1622401 gatcatatga caaagcgatg gtttaatgta ggcaaaatcg taaataccca cggaatcaaa 1622461 ggcgaagtgc gggtgatttc aaaaacagat tttgccgaag aacgatacaa gccgggaaac 1622521 acgctgtatt tgtttatgga cggccgtaac gaaccagtgg aggtaacggt aaacacacat 1622581 agactgcata agcaatttca tctcctgcag tttaaagaaa gacaaaacct aaatgaagta 1622641 gaagagctga aaaacgcaat cattaaagtt cctgaagaag aattaggaga gctgaatgag 1622701 ggtgaatttt atttccacga aattattggg tgtgaagtat ttactgaaga aggcgaactc 1622761 atcggaaagg tcaaagaaat tttgacgcct ggagccaatg acgtttgggt catcggacga 1622821 aaaggaaaaa aagacgcact cattccttac attgaatcag tggttaaaca tatcgatgtc 1622881 agggaaaaga aaattgagat tgaactcatg gaagggttaa tagacgaatg aaaatcgatt 1622941 ttttgacgct gtttcccgaa atgtttgaag gcgtgctcgg ctcatcgatt cttcaaaaag 1623001 cccaggaaaa agatgcggtg cagtttcaag tcgtaaattt ccgagagtac tctgataaca 1623061 agcacaatac tgttgatgat tatccttatg gcggcggggc aggcatggtt ctcaagcccc 1623121 agcctgtttt tgacgcggtc gaggacctga catcaaaggc agccgctgct ccgcgtatta 1623181 tcctcgtatg cccgcaaggt gagcgtttta cccaaaaaaa agccgaacaa ttagctaagg 1623241 aagagcattt gctgttcatt tgcggccact atgaaggcta tgatgaacgc attcgcgagc 1623301 acttggtaac ggatgaaata tcaattggcg actttgttct gacgggcggt gagctccctg 1623361 caatgatgat cgcagacagt gtggtcagac tgcttccggg tgtactgggt aaagaggctt 1623421 cccatattga ggattccttc agcaccggac ttttagagca cccgcattat acaagaccgg 1623481 cagattacaa aggtttaaaa gtgcctgaaa cactcttgtc aggaaaccat gcaaaaattg 1623541 aagaatggcg gaataaagaa tcgatcagaa ggacctacct aagacgtccg gatctgttga 1623601 aagaccaccc gcttacagag cagcaaagaa agtggatttc tgaatgggaa aaagaataga 1623661 ttttattgca taggctatga aattgtgata agatactact tgtggcttaa gcgggcttat 1623721 ccgctgcaag cttgaaaacg atgttccgct gtgccggttt ttgtggccaa gagcatctgt 1623781 tggaaggagt tgaaaacgat gcaaaaacta attgaagata tcacaaaaga acagcttcgt 1623841 actgatcttc ctgcgttccg tcctggtgac actttacgtg tacacgttaa agttgttgag 1623901 ggtaaccgtg agcgtatcca gatctttgaa ggtgttgtga ttaagcgtcg tggtggtgga 1623961 atcagcgaaa cgttcacagt tcgtaagatt tcttacggtg ttggcgttga acgtactttc 1624021 ccagtacaca caccaaaaat cgcgaaaatc gaagttgtac gttacggtaa agtacgccgt 1624081 gctaaacttt actacctgcg tgaacttcgc ggaaaagcgg ctcgtattaa agagatcaga 1624141 cgataatgat aacgaacgaa aagagcttgt tacctgtaac aagctctttt tttatacaga 1624201 atttgaaaat gccggacagg catcgtaaaa tacataaagg acaacaatga atcatgcata 1624261 ctgaagataa aggcggtgtt cgtgtcacat gacaattcaa tggttcccgg gccatatggc 1624321 aaaagcaaga agggaagtaa ccgaaaaatt aaaattaatc gatatcgtat atgaattggt 1624381 agatgccaga attccaatgt catcaagaaa cccaatgatt gaagatattc taaaaaacaa 1624441 gccgcgaatt atgctgttaa acaaggctga caaagcagat gcggcagtta cacagcagtg 1624501 gaaagagcac tttgagaacc aggggatccg ctctctgtct attaattctg taaatggaca 1624561 agggttaaat caaattgtgc ctgcatcaaa agagatcctc caagaaaaat ttgaccggat 1624621 gcgtgcgaaa ggtgtgaagc cgagagcgat tcgcgctttg attatcggca ttccaaacgt 1624681 cggaaaatca acgctcatca accggcttgc aaagaaaaac atagcaaaaa cgggagacag 1624741 acctggtatt acgacttctc aacagtgggt caaagttggg aaagaattag agctattaga 1624801 tacaccggga attttgtggc ctaaatttga ggatgagctt gtcggtttga gactggcagt 1624861 caccggggct attaaagact cgattatcaa tttgcaggac gtggccgtgt ttggtcttcg 1624921 ttttctcgaa gaacattacc cagaacggct taaagagcgt tatggccttg atgagatccc 1624981 agaggacatt gccgagctgt ttgatgcaat aggtgaaaag cggggctgtc tcatgagcgg 1625041 tgggctcatc aactacgata agacgactga agtcatcatt cgcgatattc gcactgaaaa 1625101 gttcggcagg ctgtcatttg aacagccgac gatgtaaagg cgcgcagaaa tgcgggtctt 1625161 tattttttct tggctgaacc gatacataca gtaagggaga agagaaagtg aatacattaa 1625221 ccgtaaagga cattaaagac cgtttgcagg aagtgaagga tgcacaagac ccatttattg 1625281 cccaatgcga aaacgacccg agaaaaagcg ttcaaacgct tgtagagcaa tggcttaaaa 1625341 agcaagcgaa agaaaaagcg ctgaaagaac aatgggtgaa tatgacttcc tatgaaaggc 1625401 tggcaagaaa caaaggattt cgcttgattg caggtgttga cgaggtcggc cgggggccat 1625461 tggcaggacc agttgtcgcc agcgcagtca tccttccaga ggaatgtgaa atacttgggc 1625521 tgacagactc caaaaagctt tcagagaaaa aacgcgagga atattacgag cttattatga 1625581 aggaagcact ggcggtcggg ataggaattg tagaagctac tgtgattgat gagatcaata 1625641 tatatgaagc ttcaaaaatg gcaatggtga aagcgataca ggatttgtcg gatacacctg 1625701 attatttgct tgttgacgca atgacacttc cgctcgacac ggctcaggcg tcaattataa 1625761 aaggcgatgc caaaagcgtg tctattgcgg caggtgcgtg tatcgcaaaa gtgacgaggg 1625821 accgaatgat gagcgcttat gccgaaacgt atcccatgta cggctttgaa aaaaataaag 1625881 gctatgggac aaaagaacat ttggaagctc tcgctgcata cggcccaact gaattgcacc 1625941 gcaaaacttt cgctcctgtt caatctttca gataaatcac catggacaag gaggcacctt 1626001 tttaaaatga acatacgaaa tgatgtgcaa aaggcgctgc agcacctttt cgggcgtaca 1626061 gccgtcccgc aggaaacatc aaaagtaaac gaagcgctaa acggggagaa gcgtctcctc 1626121 ttaggaaaag tgcttcgttt actaggagat cagcatgccc tgatccaagt cggcaatcaa 1626181 actgttcagg gaaaacttga aactcagctt cgtcctcagg catactattg gttttcctac 1626241 gaaaaaaaaa cggcagagca aacaggccgt cttcaggtcg ttcaaagctt tgatcaaaat 1626301 cctaaaacca ttcaggatgc agctggcaaa cttttaaatg ctatttcagt gaagacgtca 1626361 aacgcagctc tcatgatgac aggagcgatg ctgaaaagca aaacacccgt aacagaaaat 1626421 gatatcaaaa cagctgtccg ctggatggac acgctgcctt cgcaagacac aaaaaaagca 1626481 gttgaaacgg ttctcttcgc tttaaagcgt gatcttccca ttcactccga gattttgaat 1626541 ggtgttcacg ctgtgaaatc gcctgttccg ttgcatcagc acgtatccca gctgctacag 1626601 gcaatcgacc aaaaccctca gcagagccaa atgatgtcaa agctaaagga agcagtcacg 1626661 gtgcttttaa atagtgaaat cgatgtccat gcagaacggc tgattgataa gcttatttct 1626721 ttaaccgaca atacgaaagc accttctccg acgaatacag ctggaagcag ggagcttagc 1626781 acaccagctg gctcccccgg aaaagccagc ctgccgattg caaatcacac agcagaacag 1626841 ggaagcatac aagaagagcc tgttaaaaca gcagcagaca ttccaattaa agaagcccgc 1626901 cagctgctgg tgaagctgac ggaatctgct gaaaaaaaca gtctccaaat tgtgaaagaa 1626961 gcagcaaatt ggattaaagc ggctgcttca tcgggtgata gtaagtcact tgcagcttca 1627021 gctgttttac aggcggcaca agtcacagat caggaagccg aagtcttttt aaaggctgtt 1627081 cagcagacag caccccattt ggcggataag gcagatgttc tttctttctt atccaaagtg 1627141 aaaacggcaa tcggcgcaag ggacgaggtt gcgttcatta aagcgtttga acaaggaagc 1627201 gcagtcacat ctggcgaaat gcaatccatc aagctggctc tttctgcctt aagagcatcg 1627261 catgaggtag ccgaaccagt caaacaagaa gccgatcagc tttttcataa attaaatggc 1627321 cagcttttca tgcagcagga ccatccatca tacagccaaa ttgtaatgtc atttccgatg 1627381 ttttcgaagt caggggttca ggacatgact gttctgttta aaggaaagaa agaagcggat 1627441 ggaaagcttg atccttccca ttgccgcctt ttgtttttgc tgcagcttga tacactaaaa 1627501 gaaaccgtcg ttgattgctt ggtacagcaa aaagtcatga ccattacaat agagactgat 1627561 ttcgagctgc aggctgcgat cgatccgatg gtgcccgcgc ttaaacaggg gctaaaggaa 1627621 atggggtaca gcctttcagg ggtaaacgct aaaaaaaggg ttcacaccga agaaaaggct 1627681 tcaatcgatc aatatataac aagtatcagt gatcaggaag tggatgtgaa aatatgaaag 1627741 agcagacacc gatcagaaaa gctgttgctc tccattatga cgaacaaaaa gacaaggcgc 1627801 cgagagtgat tgccacaggg aagggccatg tagctgacaa cattataaaa gaagcgaaaa 1627861 aagcaggggt cccgattcaa gaagatcgga cccttgtcga attaatgcgc catttgacgg 1627921 tagatgatca aattcctgaa gctctttatg aaacggtagc cgagattttt tcattcattt 1627981 acaaattgga cgaaagcgta aaaaacaaaa aatagctaaa atattcccca tccttctttg 1628041 aaatttatgt ttttaataaa gtaaaagttt gaatgtttag aaggattaaa agattttgca 1628101 tcgaactgta gacaattctt ccagtattat tatagaatga aagcgcagtc tattttagtt 1628161 ttgttacata agttaggagg atgggaaatg aatatccatg agtaccaggg aaaagaagtc 1628221 ctcagaaaat atggggtatc tgttcctgaa ggtaaagtgg cttttacagc agaagaagca 1628281 gttgagagtg caaagagctt atccagctcg gtttatgtcg taaaggctca aattcatgct 1628341 ggcggtcgag gcaaagctgg tggggtaaaa atagcaaaat cattagacga agtaaaagcg 1628401 tatgccgaag aactattagg gaagacccta gttacacatc agacgggtcc ggacggccaa 1628461 gtaataaaac gcttacttat tgaagaaggc tgcgatatta aaaaagaata ttacatcggt 1628521 ctagtgcttg accgcgccac ttcaagaatc gttttaatgg cttctgaaga aggcggaacg 1628581 gaaattgaag aggttgcgga gaaaacacca gaaaaaatca aaaaagctgt cattgatcca 1628641 gctgttggcc ttcaaggcta tcaagccaga gaaattgcat tcgctattaa tattccaaaa 1628701 gagctcgtgg gaaaagctgc taaatttatg cttggactat ataaagcgtt tgttgagaaa 1628761 gactgctcaa tcgccgaaat caatccgctt gttgtgactg gcgacggaaa tgtgatggcg 1628821 cttgatgcaa aattgaattt tgacagcaat gcgttgtacc gacaaaagga cattatggaa 1628881 tacagagatt tggatgaaga agatccgaaa gaaattgaag cgtccaaata tgatctaagc 1628941 tacatttccc ttgatggaaa tatcggctgt atggtaaacg gcgcgggact tgcaatgtct 1629001 acgatggata ttatcaagca ttatggagga gaaccggcca acttccttga tgtgggcggc 1629061 ggtgcaaccg cggaaaaagt cacggaagca tttaaaatca ttctttctga tcaaaacgtt 1629121 aaagggattt ttgtcaacat tttcggcggc attatgaaat gtgatgtcat cgcagaaggg 1629181 gttgttgaag cgactagaca agttggtttg acattgccgc ttgtcgtccg tcttgaaggc 1629241 acaaacgtgg atctagggaa gaaaatcctt agtgaatcag gattaaacat tacatctgcg 1629301 gaatcaatgg ctgacggcgc gcagaaaatc gtatccttag tttaagaaag aatgaaaggc 1629361 aggggaccaa ataatgagtg ttttcattaa taaagataca agagttattg tgcaagggat 1629421 tacaggttct accgctttat ttcatacgaa gcagatgctt gaatacggca caaatatcgt 1629481 tggcggtgta acacctggaa aaggcggaac agaagcggaa ggtgttcctg tatttaatac 1629541 agtggctgaa gcagttcaaa caaccggcgc taacgcgtct gttatatatg tgcccgcacc 1629601 gtttgcagct gatgcgatta tggaagcggt agatgcggag cttgatctcg tgatttgtat 1629661 cacagaacat atcccggttt tggatatggt gaaggtcaaa cgcttcatgg aaggcaagaa 1629721 aacgagactg atagggccga actgtcctgg tgtcattacg cctgaagaat gtaaaatcgg 1629781 cattatgccc ggatacatcc ataaaaaggg tcatgtaggc gttgtatcac gttcaggaac 1629841 attaacatac gaagcggtgc accagctctc agaagcgggt gtagggcaat ctacagctgt 1629901 tggaatcggc ggcgaccctg taaatggaac aaactttatt gacgttttaa aagcgtttaa 1629961 cgaagatcct gacacacacg cagtcatcat gattggcgaa atcggcggta cggccgaaga 1630021 ggaagcggca gagtgggtaa aagccaacat gacaaaaccg gtagtcggtt ttattggcgg 1630081 taaaacagca cctcctggga agcgcatggg gcatgcaggc gccattattt ccggcgggaa 1630141 agggacagct gatgaaaaaa tcaaaaccct taatgcatgc ggaatcgaag ttgcagagac 1630201 accttctgtc atgggtgaaa ccttaatcaa ggtgctgaaa gagaagaact tgttcgaaac 1630261 ttgtaaaacg cattaataaa aaagggacag ccgtcaaggc tgttcctgct ttttctaaca 1630321 aaaggaggtc aatctattgg atcaggccgc tgtctgccta acgatttgca gaatcaatca 1630381 attattatcc ccatcccttc tattaaaatg gtggaaagcc gatccgtcta tgtcgctgac 1630441 atcacccgtg ttacaaacgg ttactcgtga tcaaataaaa gcagctgcat taaaaaacga 1630501 aatagaacaa ttttatccaa agctcccgcg tgtacttgct gcttatcgtg agcaaggcat 1630561 taacaccatc cctatttctt caaagcaata tcctttctgg cttaaaagca tttatgatcc 1630621 ccctgccgta ctgtttgcaa aaggtgatat gactcttctt tcgaaaggga gaaaaattgg 1630681 aattgtaggc acaagaaatc caacagctta tgggaaacaa gttgtcaatc atcttacaaa 1630741 agagatctgt cgtaaaggtt gggtgattgt cagcggactg gcgtctggga tagacggaat 1630801 gtcccatgct gcaagtatta aggcgaaggg gcggacaatt ggcgtcattg caggcggatt 1630861 tcaacacatt tatccccgag aaaaccttca gttagcagat cacatggcta aacaccatat 1630921 cctgctgtca gagcacccac ctgaaactaa accccaaaaa tggcatttcc ctatgagaaa 1630981 ccgtattatc agcggactaa gtgaaggcgt tattgtcgtt cagggcaaag aaaaaagcgg 1631041 ttcgctgatt actgcctatc aagcattgga acaagggaga gaggtatttg ccgtacccgg 1631101 ttcattgttt gacccttacg ccggaggtcc tataaaactg atccagcagg gggctaaagc 1631161 catatggtca gcagaggata ttttcgagga acttcctgag agaaacgttc aatatacgga 1631221 acccttttga attatcgttt gacaaacggt attgtaatat ttaataatag tgaggattta 1631281 aagttgcata ttgttttcta tttaattaat gacgttcatg ataaagaatg aaatgttgaa 1631341 agccaaataa agacagctgc aaaaataaaa ttgaaatatc ttgaaaagag agagaacacc 1631401 tcttgagggg gatgaaaatg tctgattatc tagtcatcgt ggaatcgccc gctaaggcga 1631461 aaacgattga acgttactta ggtaaaaaat ataaagtaaa agcatcaatg ggacatgtcc 1631521 gggatcttcc aaaaagtcaa atgggagttg acatagaaca gaattttgaa ccgaaatata 1631581 ttaccattcg aggtaaaggc ccggtattaa aagagctgaa aacggctgcg aaaaaagcca 1631641 aaaaagtgta tctcgcagct gaccccgaca gagaagggga agcgattgca tggcatttgg 1631701 cacacagtct tgatttagat ctcaactcag actgccgtgt ggtgtttaac gaaattacaa 1631761 aagacgctat taaggaatcg tttaagcatc cccgcatgat caatatggat ttagtggatg 1631821 cacagcaagc gagacgtatt ttagacaggc ttgtcggata taaaatcagt ccaatcttat 1631881 ggaaaaaagt caaaaaaggg cttagcgcag gacgcgtgca atccgttgcc ctccgtttga 1631941 ttattgaccg tgaaaaagag attaacgact ttaagcctga ggaatattgg acaattgacg 1632001 gtacgttctt aaaaggtcaa gaaacctttg aagcgagctt tttcgggaaa aacggcaaaa 1632061 aacttccttt aaatagtgaa gctgatgtaa aagagattct ttctcagctc aaagggaatc 1632121 aatatacagt tgaaaaagta accaaaaagg aacgcaaacg taatcctgct ttgcctttta 1632181 ccacttctac cctgcagcag gaagcggctc gcaagctcaa tttcagagcg aagaaaacga 1632241 tgatgattgc acagcaatta tatgaaggaa ttgatttagg aagagaagga acggttggtc 1632301 tgatcacgta tatgagaacg gattcaaccc gtatttcaaa tacggctgtt gatgaagcag 1632361 ctgcatttat tgatcagaca tatggaaaag agttcctagg cggaaaacgg aagcctgcga 1632421 aaaagaatga aaatgcccag gatgcccacg aagcaattcg gccgacatca gttcttagaa 1632481 aaccaagtga attaaaagca gtcctcggca gagaccaaat gagactgtat aaattaattt 1632541 gggagcgttt tgttgccagc caaatggcac cggctgttct cgatacaatg agtgtcgacc 1632601 tgacaaacaa cggtttgaca tttcgtgcaa atggaagtaa agtcaagttt tccgggttta 1632661 tgaaggtgta tgttgaagga aaagacgatc aaatggaaga aaaagaccgg atgctgcctg 1632721 acttacaaga aggcgacacg gtattatcaa aagatataga acctgagcag cattttaccc 1632781 agccgcctcc gcgatatact gaggcccggc ttgttaaaac ccttgaagaa cgcggtatcg 1632841 gccgtccatc cacatatgct ccgacacttg atactattca gcggcgcggc tacgtggcat 1632901 tggataataa acgtttcgtt ccgactgaat taggtcagat cgttcttgac ttgatcatgg 1632961 agtttttccc tgagatcatt aacgttgagt ttacagctaa aatggagaga gatcttgatc 1633021 atgttgaaga aggaaatacc gaatgggtca agattatcga taatttctac accgattttg 1633081 aaaaacgcgt caaaaaagcc gaatcggaaa tgaaggaagt tgagattgaa ccagagtatg 1633141 ctggagagga ttgtgaattg tgcagttctc caatggtata taaaatggga cggtacggta 1633201 aattcttagc ttgctccaac ttccctgact gccggaacac gaaaccgatt gtgaaacaaa 1633261 tcggtgtgaa gtgcccgagc tgcggagaag gaaacattgt tgagcgaaaa tcgaaaaaga 1633321 aacgggtgtt ttacggctgt gaccgttatc cggactgtga attcgtatca tgggacaaac 1633381 caattgaacg aaaatgcccg aaatgcggaa aaatgctcgt cgagaaaaaa ctcaaaaaag 1633441 gtatacaagt ccaatgcgtg gaatgcgatt ataaggaaga accacagaag tagcggtgag 1633501 cagggtcttg ctcaccttct ttgtgtgtta aaagaaggcc ttgaataata aactaggaga 1633561 tgtgaaagat gaaccaacaa acagtgaatg taatcggagc cggactcgca ggaagtgaag 1633621 cagcatggca gcttgccaaa cgtgggattc aagtcaaatt gtatgaaatg cggccagtta 1633681 aacaaacgcc tgcgcatcat acagataaat ttgctgagct tgtctgcagc aactctcttc 1633741 gctctaatac acttgctaac gctgtcggtg tattaaagga agaaatgcgt gcgcttgatt 1633801 cagccattat cgctgcggct gacgaatgtt cggtgcctgc cgggggcgct cttgcagtag 1633861 accgtcatga atttgccgca agtgtgacaa atcgggtgaa aaatcatcca aacgtaaccg 1633921 ttattaatga agaagtgact gaaattcctg aaggccctac tatcatcgca acgggtccgt 1633981 taacatctga atcgctgtct gcccagctga aggagctgac tggagaggac tatttatatt 1634041 tttatgacgc agcggcgcca attgtagaaa aagacagcct tgatatggat aaagtgtacc 1634101 tgaaatcccg ttatgataaa ggtgaagcag catatttgaa ctgcccgatg acagaagaag 1634161 agtttgaccg ttttcatgaa gcattaacat cagcagaaac agtgccgtta aaagaatttg 1634221 aaaaagagat tttctttgaa ggctgcatgc cgattgaagt catggcaaaa cggggtaaga 1634281 aaacaatgct tttcggtccg atgaaaccag ttggtctaga gcatcctgtt acaggaaaac 1634341 gcccttatgc cgtcgttcag ctcagacagg atgatgctgc gggaacactt tataatattg 1634401 taggattcca gacacattta aaatggggag accaaaagga agttctcaag ttgattccag 1634461 gacttgaaaa tgtagaaatc gtcagatatg gcgtgatgca tagaaacaca tttattaact 1634521 ctccaagcct gttaaagccg acttatcaat ttaaaaaccg cagtgatctg ttctttgcag 1634581 gccaaatgac gggagtagaa ggatatgtgg aatcagctgc ctcaggactt gtagcaggca 1634641 ttaatgcggc gaagcttgta ttgggagaag agcttgtgat cttccctcag gaaacagcaa 1634701 ttggcagtat ggcacattat attacaacaa caaaccagaa gaacttccag ccgatgaatg 1634761 caaactttgg gcttttgaaa gaattgccag ttaaaattaa aaataaaaaa gaacgaaatg 1634821 aacaatacgc gaaccgtgcg attgaaacaa ttcaaacaat ttcgaaaaca atataggtat 1634881 tgattgcaac ctgagcgcga tttgtgatac catttaaaag cccttcctgg ggaggtatta 1634941 ggcatggaga atgttaagaa tttcgtaaag ttattcgttg aatatttaca aattgaaaaa 1635001 aattattcac aatatactat tgtgaattat gtggattcaa ttgaagaatt cgagactttc 1635061 ctgcgcgttc aaggtataaa tggatttgaa gaagctgcat atcaagatac taggattttt 1635121 ttgacagaag cctatgaaaa aggtttatcg agaagaacaa taagcaaaaa gatatctgca 1635181 ttaagaagct tttataagtt tctgatgcgg gaaaagctta ttgaagaaaa tccgtttcag 1635241 cttgttcatc tgccaaaaca ggagaaacgg ataccgaagt ttctatatca aaaagagctt 1635301 gaggagctgt ttgaagtttc agatataagc cagccggccg gaatgaggga tcaagcgctg 1635361 ttagagctgc tctatgccac tggaatgagg gtcagtgaat gctgttccat aactattaac 1635421 gacgttgatt tatttatgga cactgtgctt gttcacggta aaggcaagaa gcagcgctat 1635481 atcccctttg ggtcttatgc ccgcgaagcg ttgaaggtat acatgaatag cggaagacag 1635541 tgcttgctga tgaaggcaaa agaacctcat gatctattat tcgtaaatca aagaggcgga 1635601 ccgcttacag cccgtggcat cagacatatt ttaagcgggc ttgttcaaaa agcgtcaagc 1635661 actttacata tccatccgca tatgcttcga catacgttcg ccacgcatct gttaaatgaa 1635721 ggagcggatt tgagaagcgt tcaagaactg ctcgggcatt ccaatctgtc ttctacacag 1635781 atatacacgc acgtttcgaa ggaaatgttg agaaacacat atatgtctca ccatccaaga 1635841 gcatttaaga aaaattaaag gaggcccttt atgtcatctt ttcatgcgac cacaatattt 1635901 gccgtacagc ataaaggacg aagcgctatg tccggagacg gccaagtaac atttggtcag 1635961 gctgttgtca tgaaacacac ggcacggaaa gtgagaaaac tgtttaacgg caaagttctt 1636021 gctggttttg cgggatctgt tgcagacgct ttcactttat tcgaaaagtt tgaagctaag 1636081 cttgaagaat ataacggcaa cttaaaacgg gcggctgttg agcttgcaaa ggaatggcgc 1636141 agtgataaag tgctaagaaa gctcgaagcc atgctgattg ttatgaatca ggatactttg 1636201 cttctcgtat cgggaacagg cgaggtgatc gaaccagatg acggcattct cgcgattgga 1636261 tcaggaggca attacgcttt ggcagcggga agagcactga aaaagcatgc cggggaaagc 1636321 atgtctgcaa gtgagattgc cagagccgcg ttagaaacag caggcgaaat ttgtgtttac 1636381 acgaacgatc aaatcatact ggaagagctt gaatagaaag gacttgaggc gcatggaaaa 1636441 aaaaccgtta actcctagac agattgtaga tcggttagac caatatattg tcggtcagca 1636501 aaatgcgaaa aaagctgtcg ccgtggcatt aagaaaccgc tatagaagaa gtcttctgga 1636561 tgaaaagctg aaggacgagg tcgttccgaa aaacatttta atgatgggtc ctaccggcgt 1636621 cgggaaaact gaaattgcca gacgaatcgc taagctttca ggtgcgccat ttatcaaaat 1636681 tgaagctact aaatttaccg aagtcggcta tgtaggcaga gatgttgaat caatggtcag 1636741 agatcttgtg gagacttctg ttcggcttat aaaagaagag aaaatgaatg aagtaaagga 1636801 acaggcagaa gaaaatgcaa acaaacgcat tgttcgtctg ttagttcctg ggaagaaaaa 1636861 acaatctggt gttaaaaatc cgtttgaaat gttttttgga ggcagccagc cgaatggtga 1636921 agatgaggcg gagagccagg aagaagcaaa catcgaagaa aaaagaaaac gaatggcgca 1636981 tcagctggct ttaggagagc tcgaagacta ctatgtaaca gtagaagtcg aagaacagca 1637041 gccttctatg tttgacatgc tgcagggctc gggtatggag cagatgggta tgaacatgca 1637101 ggatgcgctg agcggattaa tgccaaagaa aaagaagcgg cgcaaaatga cagtcagaga 1637161 agccagaaaa gtcctgacga atgaagaagc aagcaaactc atcgatatgg atgaagtcgg 1637221 ccaggaagct gttcagagag cagaagagag cgggattatc tttatcgatg agattgataa 1637281 aatcgcaaag aacggcggtg catcttcttc tgccgatgtt tcaagagaag gtgttcagcg 1637341 ggatatcctt ccgattgttg aaggttctac cgttgtcaca aaatatggtt ctgtaaaaac 1637401 agaccatgta ttatttattg cagcaggagc gtttcatatg gccaaaccgt ctgatttgat 1637461 tcctgagctg caggggcgtt tcccgattcg tgtagaactg aacaaactca cggtagacga 1637521 cttcgtgaga attttggttg agccggataa tgcgctgctg aaacaatatc aggcattatt 1637581 gcagacagaa ggtatatctc ttgaattttc tgacgaagct attcataaga ttgctgaagt 1637641 tgcttatcat gtgaaccagg acacagataa tatcggtgcg agacgccttc atacaatact 1637701 tgaacgccta ttagaagatt tgtcgtttga agctccagat gtaacgatgg agaaaataac 1637761 gattacacca cagtatgtcg aagaaaagct cggaacgata gccaaaaaca aagatttaag 1637821 tcaatttata ttgtgaaaaa tttaatatga ggaatgttta ggaggattat ttatcatggc 1637881 tttattacaa aaaacaagaa ttattaactc catgctgcaa gctgcggcag ggaaaccggt 1637941 aaacttcaag gaaatggcgg agacgctgcg ggatgtaatt gattccaata ttttcgttgt 1638001 aagccgcaga gggaaactcc ttgggtattc aattaaccag caaattgaaa atgatcgtat 1638061 gaaaaaaatg cttgaggatc gtcaattccc tgaagaatat acgaaaaatc tgtttaatgt 1638121 ccctgaaaca tcttctaact tggatattaa tagtgaatat actgctttcc ctgttgagaa 1638181 cagagacctg tttcaagctg gtttaacaac aattgtgccg atcatcggag gcggggaaag 1638241 attaggaaca cttattcttt cgcgtttaca agatcaattc aatgacgatg acttaattct 1638301 agctgaatac ggcgcaacag ttgtcggaat ggaaatccta agagaaaaag cagaagaaat 1638361 tgaagaggaa gcaagaagca aagctgtcgt acaaatggct atcagctcgc tttcttacag 1638421 tgagcttgaa gcaattgagc acatttttga ggagcttgac ggaaatgaag gtcttcttgt 1638481 tgcaagtaaa attgctgacc gtgtcggcat tacccgttct gttattgtga acgcactcag 1638541 aaagctggag agcgccggtg ttatcgagtc tagatcatta ggaatgaaag gtacttatat 1638601 caaggtacta aacaacaaat tcctaattga attagaaaat ctaaaatctc attaatcaca 1638661 aaaagaaccc tttttgaggg ttcttttttt atttcaaata aaggaaatca ataagcttta 1638721 tttcctgggt tgaaagtctt tctatgtaat aattttaata aattttgcat ttttcttcaa 1638781 aaagtttcaa aaatgccgaa aagaaaggag aaaaaacaga aattctgcta ttttcaggct 1638841 tatatcaagg cgagaaatgt agttctaaca atctaggact ttatacctag ttgcaaaata 1638901 gataattgtg aggacatttt tttacacgaa cttcatagac tttatgcctg ttatttctta 1638961 caataagcat atagttttac aattctcgac aaggatattg agggtgaaaa aaactgaaat 1639021 ggaggtaagt ggatttgagc ttattttctg gaacgataca aaatcttgaa aatgccttga 1639081 gcagagcgga tattaagcaa aaagtcataa ctaataatat cgccaatata gatacaccga 1639141 actataaggc aaaaaaagtc tctttccaaa atttattaga tcaagaatcc tcgcgtcttg 1639201 aagcgataaa aacagactat cgtcatgttg atttttctga tactgattcg aattattcaa 1639261 ttgttgcgag cggagataca tcgtatcagc aaaacggaaa caatgttgat gttgacaaag 1639321 agatgacaga attggcgcaa aatcaaatca actatcaagc tttggttgaa agaatgaacg 1639381 gtaaatttaa ttcgctgaag accgtattaa caggaggaaa atgatgacag cttttcatag 1639441 cttaaatgtt tcagcatcgg ctttaacagc tcagcgagtc agaatggacg ttgtatcatc 1639501 taacttagca aatatggata cgacaagagc taagcaggtg aatggagagt gggtgcctta 1639561 cagaagaaaa atggtttccc ttcagtcaaa aggtgaatcg ttctcttcca ttctcaattc 1639621 tcaaatgagc ggaagcggga atgctggaaa cggtgtgaag gtttcaaaaa ttacggagga 1639681 tgattcggat tttaatcttg tctatgatcc gacagaccct gatgcaaacg ctgaaggata 1639741 tgtacaaaag cctaatgttg atccattaaa ggaaatggtt gatcttgtca gcagcactag 1639801 atcatacgag gcgaatgtca cggcgatgaa tgccacaaag ggaatgctga tgaaggcgtt 1639861 agaaatcgga aagtaggtga atgaatgtga ttaatgcaat ttctcctttt caggttcaaa 1639921 atactcaaaa cactcaaaat gcaacaaatc aagtaaacaa tagccaaaaa acagattctt 1639981 caaatcaaac aagcttttcg gagcttttaa aaaactctat tagttcgtta aatgagtccc 1640041 aagtagcttc tgacaacatg actaatgcct tggctgcagg aaaagatgta aatcttgatg 1640101 aggtcatgat cgctgctcaa aaagctagca tctctctaac tgcagcaaca gagttccgca 1640161 ataaagctgt ggaagcttat caggagatta tgagaatgca aatgtagggg gtctgacgat 1640221 ttagagaaag agtggaatga ccgggggtta acatgaatcg tactctaatg caaatgaaaa 1640281 acaaaacgag tgagttttgg aaaaatagat ctaaattaca aaagatttta atggttagtg 1640341 ctttagcggc aattattatt attggaatta ttattagtgt ttttgcttca aattctaaaa 1640401 tggcgccgct gtacaaagat ttgtctgccg aagaagcagg acaaatcaaa gaagaattgg 1640461 atgcaaaaaa agtgccaaac gaactttcga atggcggtac agtgattagt gttccggagg 1640521 atcaggttga ttctttgaaa gtgcagatgg ctgcagaagg acttcctaaa acgggatcaa 1640581 ttgattattc gttttttgga cagaatgccg gctttggttt gacagacaat gagtttgata 1640641 tggtgaaagt gaaagctaca cagacagaac tgtcaaactt gatcaatgaa atggacggta 1640701 ttaaaaattc aaaagtaatg attaatctcc cgaaagacgc tgtgtttgtc ggtgaagagc 1640761 aatctgcagc atctgcatca atcgttttgc agattcaacc gggttataca cttgatcaaa 1640821 gccaaatcaa cggattatat catctggtat ctaaaagcgt gccaaaccta aaagaagata 1640881 acatcgtcat catggaccaa aattctacat actacgacaa atcagacagc gatgcagggt 1640941 cctacgcgga tagttattct tctcagcaag gaattaagtc tcaagttgaa aaagacattc 1641001 aaaaacatgt acagtcactg ctgggtacga tgatgggcca agataaagtc gttgtctccg 1641061 ttacagcaga cattgatttc acaaaagaaa atcggacaga agacattgtc gaacctgtgg 1641121 ataaagaaaa catggaaggc attgcagtca gcgctgaaaa ggtatctgaa acatatcagg 1641181 gcgacggtgc agccaacggc ggaactgccg gaaccggcga ggaagatgtt acaaattata 1641241 aggctgacgg tgaaaatacc gaaagcggga actacgaaaa aaacagcaac aaaatcaatt 1641301 acgaggttaa ccgaattcat aaagaaatcg ctgaaagtcc ttataaggtc agagatttag 1641361 ggattcaagt aatggtagag ccgcctgatg ccaaaaacac tgcgtcgcta tcaactgaaa 1641421 gacaggatga tatacaaaaa atcctttcaa ctgtagtcag aacatctttg gataaagatg 1641481 aaacgcaaaa tcagaattta tctgatgctg atatcaataa taagattgtt gtttccgttc 1641541 agccattcga cggaaaagtc aatttggata caaatacgga agaatcctca ggtatcccgc 1641601 tgtgggcata tattgtaggc ggtgttttaa tcgcagcgat cattgttctg atcattatgc 1641661 ttatcagaaa gaaacgggcg caagaggatg aatttgagga atatgagtat gaggttcctc 1641721 aagaaccaat caatttgcct gatatcaacg aagaggaaaa tgaaacagcg gaatcagtca 1641781 gacgaaaaca gcttgaaaag atggcgaaag acaagccgga agattttgca aaactgctga 1641841 gaagctggct ggccgaggat taggaggaat tagaaatggc gagacgtgat caagataagc 1641901 ttacaggaaa acaaaaagca gccattctca tgatttcctt ggggttagat gtgtcagctt 1641961 ctgtctataa gcacttaacc gatgaagaaa ttgaaaggct tactctggaa atatcaggtg 1642021 ttcgaagcgt cgatcatcaa aaaaaggatg aaatcataga agaatttcat aatatagcca 1642081 ttgcgcaaga ttatatttct caaggcggtt taagctatgc aagacaagtt ctggaaaagg 1642141 cgcttggaga ggataaggcg gagaacattc taaacaggct gacttcttct ttgcaggtta 1642201 aaccatttga ttttgccaga aaagcggagc cagaacaaat tttgaatttt atccagcaag 1642261 agcatccgca gacgatggcg ttaatcttgt cttatttaga tccagtgcag gccgggcaaa 1642321 ttttatccga gctgaaccct gaagtgcagg ctgaggttgc gagaagaatc gcggtcatgg 1642381 atagaacgtc tccagaaata attaacgagg tagaacggat tctggaacaa aaattatctt 1642441 ctgcatttac tcaggattat acacaaacag gcggaattga agctgttgtg gaagtgttaa 1642501 acggggtaga cagagggaca gagaagacga tcttggattc attggaaatt caggatcccg 1642561 atcttgctga agagattaaa aagcggatgt ttgtcttcga agatattgtc acacttgata 1642621 accgtgcaat tcagagagtc attcgcgatg ttgagaacga cgatttgctc ctttcattaa 1642681 aggttgcaag cgaggaagtc aaagaaattg tgttcaacaa tatgtcacag cgtatggttg 1642741 aaaccttcaa agaagaaatg gagtttatgg gccctgtacg tttgaaagat gtagaagaag 1642801 ctcaatcaag aattgtaagc atcgtcagaa agcttgaaga agccggtgaa attgtaatag 1642861 caagaggcgg aggggatgat attattgtct aatatcatta aacaagaatc atctatttct 1642921 ccacaaaagg aaaaaagaaa actttctata caagaggtgc gtattgatca ttctcacctt 1642981 ttgcaggctg aagagaaccc ggaggcgctt atggcccgag tgaaagagga agctgaccgg 1643041 atttctgagc aggcaaacag tcatatagaa aatattcgcc gtcaaattga acaggagaaa 1643101 aacgattggg cggctgaaaa acagaagctt attgaagaag caaaagccga gggctttgaa 1643161 caaggagtag cgctgggcaa agctgaggca atgaaacagt atgcagaact gatcggccaa 1643221 gcaaacagta taactgaaat gtccagaaaa gctgttgagg acaagcttga agacgctaat 1643281 gaagaaatcg ttgagcttgc cgttgcccta gcaaaaaaag tttggcagca aaagtctgat 1643341 gataaagagg ctttcctcct gcttgtacaa caggttataa acgaagtgaa ggaatatgac 1643401 gatatatcaa tttatgttga tccatattac tatgagacaa tctttcagca aaaagatgaa 1643461 atccagcagc ttctttataa agaatgtcgg cttggcatat atgctgatga aaaagctcaa 1643521 aaaggaacct gttatattga aactcctttt ggcagggtag atgcgagtgt tgacacacaa 1643581 ttgatgcaat tgaaagataa acttctgaca gcgctggaag caggtgcagc tgaatgaaga 1643641 cacagagtct gatagattgt atagaaatga cagactcgta taaacggtac ggaaaagtca 1643701 agcgggtaat cggcttgatg attgaatcaa aagggccagc aagctcaatt ggtgacctgt 1643761 gcctgattta tgcaaaagga cagtctggga aagtcattaa agctgaggta gtcggcttcc 1643821 aggaagaaaa tattttgctt atgccttatt tagaggctgc gagcattgca cctggcagca 1643881 ttgtagaagc tactggggaa tcacttcggg ttaaagttgg gaccggactg atcggacaag 1643941 tcatcgatgc ttttggagaa ccgcttgacg gaaagcttct gccgaaaggg ctttcgcctg 1644001 tatcaacgga gcaatcaccg cctaacccga tgaaacggcc gcctatccgt gaaaagatgg 1644061 gtgttggagt cagatcaatt gacagcttgc tgacagtcgg taaaggccag cggattggaa 1644121 tttttgcagg aagcggtgtc ggaaaaagca ccttaatggg gatgatcgcc aagcagacag 1644181 aggctgactt aaacgtcatt gcacttgtcg gagaacgcgg acgagaggtt cgggagttta 1644241 ttgaaaaaga tctggggaaa gaggggctga aacgatcgat tgtagtcgtt gccacctcag 1644301 accagccagc attaatgaga ttgaaagcgg catatacagc gactgcaatt gccgagtatt 1644361 tccgagataa aggccaaaat gtcatgttta tgatggattc tgttacaagg gtggcaatgg 1644421 cgcagcgaga gattggactg gctgcaggag agcctccgac gacaaaaggc tatacacctt 1644481 cagtgttcgc tattttacct cgtttactag aacgaacagg tgcaaacgag catggaacca 1644541 ttacggcatt ttatacagtg ttggtagatg gggatgacat gaatgagccg attgccgata 1644601 ccgtacgcgg aattttagac gggcatattg tgttggacag ggcgcttgcc aataaaggcc 1644661 agtttcctgc agttaacgta ctaaaaagca tcagcagggt gatgtcaaac atttcaacaa 1644721 aacagcatct ggatgcggca aataaattcc gtgaactttt atcgacatat caaaattcgg 1644781 aagatctcat taatatcgga gcttacaaaa gaggatcatc cagagaaatt gatgaagcga 1644841 tacaatttta tccgcagctt attcaatttt taaagcaggg aacagacgaa ccggctttat 1644901 tggaagaaag cattgctgca ttaactagtt tgacaggaaa tgaggaataa acgtggctta 1644961 tcaatttaga ttccaaaagc tgctggaact aaaagaaaat gaaaaagacc aatccttatc 1645021 cgaatatcag caatcagttt ctgaatttga aaacgttgct gaaaaattat atgagaatat 1645081 gagcaaaaag gaattgctgg aacaaaataa ggaaaagaaa ttaaaaagcg gcatgagtgt 1645141 acaagaaatg aggcactacc aacaatttgt ctcaaatctt gataatacga tctatcacta 1645201 tcaaaagctt gtcattatga aaagaaatca aatgaatcaa aaacaagaaa ttttgacaga 1645261 gaaaaacatt gaagtgaaaa agtttgaaaa aatgcgtgaa aaacagttta aaatgtttgc 1645321 tcttgaagat aaagctgcag aaatgaaaga aatggacgat atttcgatta agcagtttat 1645381 gattcaaggc cattaggagc gaatgtaatg tccggcaaaa agaaagaatc aggtaagttc 1645441 cgttcggttt tgcttatcat tatcctcccg ctgatgtttc tattaatcgc aggggggatt 1645501 gttctttggg ctgctggtat caatgtctta aagccgatac aggatgctgc ggcaaaaacg 1645561 ccggttctta aagaattggt ccctgaaacc gaaaataaaa aaggcgcagc atcaagtaag 1645621 gatagcagta atacggcagc tctggaaaag accattaagg atcaaaaaag tgaaatcagt 1645681 atattgaata aagatttaga aacaagtaaa tcagaaatcg acaggctcaa tcaaaagatc 1645741 cgttcacttg aaaagacggc tgaggatcaa aaaaagtcat cagaagatca tactgaagga 1645801 tcagcagact cgaaagcttc ttctgaaaat gacaaagtga tcagtgtgta caaaagcatg 1645861 gacagcggaa aggctgctaa aattattgcc caattaaagg agcaagaagc actgaaaata 1645921 ttgaatggcc taagcaaaaa gcagcttgct gacatattgg cgaaaatgac tcctgagcaa 1645981 gcagcaacct atacagaaaa aattgctgcc agccaagaat agggggaatg aaaggtgaag 1646041 ctgcttgaat tagccggacc tttgctgcaa accacaacgg gttctgccgc taaaaacatg 1646101 aaaagtagcc agggagtttt tcaaaactgg cttatgtctg aggctggatt gaaggaactt 1646161 tcagaacaag gaaagggaac tcctaattct gaagatcagc ttttagcaga tgcgcttaaa 1646221 aagatcggtg aatggctaaa tgcaagtcct gaagatcaag acaaacaaaa tgcggatctt 1646281 ttgcaaacat taagcaaact gacagggaag caattggatg cgaatgctct gcaaatgttg 1646341 caaaatcttt tgcaagcagt tgaatcaaaa atgtcaggcg ggacggatca attgctcaca 1646401 gaaacggaga aaatcttttc agaagctaaa acggctctga gtgccaatga ttctgcttct 1646461 gacattaatg gagcactgaa gtctgataaa gagcaatcaa atcaggaaaa tgaagtatcc 1646521 gagcctgcaa aagagcttat ctatatccag atgttcatta gccagctcgt agaagggaat 1646581 aagctgactg atctcgggaa tggcaatgaa gctcatgcca tttaccaaaa tggagatcaa 1646641 ttcctttctg cattagaaaa gaagggtgta tctcaacaac taattcagga tcttaaacag 1646701 caaatattca ctaaagctga gtcaagttca aaactttact cgatgacagc gtcagagctg 1646761 aaaagttttc aaagcttaat ggatcaaatg tctatgcttc ctcaaaaagg gaccaaagaa 1646821 tggagtttag ctgaaagcca gctgaaagcc ttcttgttat cgaaatcatc cgaatcatca 1646881 caagactttg ggaagagtgt tctcacaccg ctctcgcaga gttcatccag caaaaatgca 1646941 tcggatgttt ctggaagtat tcagcctgta gatagtaaat caggactcca aatgctgttt 1647001 tcggggtatc ggggcatagg aggagttcaa acacttgatc tgcagcagat gtcatctgat 1647061 ataccaaatg ccgaaacaaa aacggtggct gatcaagtga ttaatgcgtg gaagcagatg 1647121 aaatatacgc ctttcggcag atcgacggga agtttcacta ttcggctgaa ccctgaacat 1647181 ttaggatttg tcacaatcaa gctgacaaat gaaaatggaa tgtttcagag taaaatcata 1647241 gcatctagcc aatcagcaaa agaattgctt gaacagcatc ttcctcagct gaagcaatca 1647301 ttgccgaata tggccgtcca aattgaccgt tttactcttc cggtccaaag cggggatcag 1647361 ccgatatacg gccagcttgc tgatgaacag aaacagcagc aagaggggca gagacagcaa 1647421 agacagaaaa agcaatcaaa tgattttggc gatctgctcg atgaagtgtc gatggttgaa 1647481 atggaggaag aagaatgact tctataagtt cagaatataa actgcctgaa aaaacgaaca 1647541 ctgtgtcgac gaacaacagc agcttgggga aagacgagtt tttaaaaata ttaatgactc 1647601 aagttcaaaa ccaagatccg cttaacccga ttgacgataa agaatttatc agccagatgg 1647661 cgactttttc aagcttggag caaatgatga atctgaatac gacaatgact caattcgttg 1647721 aaaaccaaga tccgtttaca acgtatgttg attggatggg aaaagaagta tcttggactg 1647781 atggtaaaag tgcaacagat aaaacaggca cagtaagctc tgttaaacat tttaaaggaa 1647841 attattatct cgttcttgat gatgggaccg agatcagtcc tgcgaatgtc atgtctgtgg 1647901 gacaatcatc taaataaaaa catctggggg aatatattat gttacgttca ctttattctg 1647961 gaatcagcgg tatgaaaaac tttcaaacaa agcttgacgt aatcggtaac aacattgcca 1648021 acgtaaatac agtaggattc aaaaagagcc gtgtgacctt taaagatatg gtaagccaaa 1648081 cgattgccgg cggttctgct gctggtgcaa caatcggcgg aacaaactct aagcaaatcg 1648141 gtttaggttc atcatctggc acaattgata caattcattc aacaagcgcg acacaaagca 1648201 caggaagaac acttgattta gcaattgacg gcgacggtta cttccgaatt gatacaggtg 1648261 acgggacagc ttatacaaga gcagggaact tctatttaga taatactgga acactggtta 1648321 caggtgatgg ctaccatgta ctaaatatga atggcggaac aattaaaatt cctactgatg 1648381 ctcaaagctt tagcattggt tctgatggaa aggtgtcaat tgttgatgct gaggggaaaa 1648441 cacaagacgg gggacaaatc gggattgtta cttttgccaa cagtgatgga ttggataaaa 1648501 tcggaagcaa cctataccgt gaatctttaa actctggaac ggccagtgca gcgaaccagc 1648561 ctggtgacgg cggaactggt gctcttaaat caggatttct cgaaatgtct aacgtcgatt 1648621 taactgacga atttactgaa atgatcgtag cccagcgcgg attccaatca aactcaaaaa 1648681 ttattacaac atctgatgaa atccttcaag aactggttaa ccttaaacgt taaggaggga 1648741 ggggaggcga gtaatcgctt ctccgctgtt ttatgattaa agtaacccgt ttgaacgggc 1648801 agccctttac actgaatgcg ctatttattg aacagattga atgttttccg gatactacaa 1648861 ttactctgtc aaatggtaag aagtttgtag taaaagaaga tgaagaagct gttctggaaa 1648921 agatcgcagc tttctaccga aaaatacaaa tatttgcaat ggatcaagga atagaggaac 1648981 cggaatgaag aaaaagttaa tgatcatatt actaattatt cttatcgtaa ttggtgctct 1649041 cggggcggcg gcttattttg ttttaggcgg aaagtccgaa aaaagtgaag cgaaaaaaag 1649101 tattgatgaa atcgttgcgt cttctgttga tgtagaagag atcacaacaa atttaaagtc 1649161 tgataacatt atccgtcttg ctattaaact tgaaactgat tctgataaat caaaagaaga 1649221 acttgagaaa cgtgatttcc aagtgaaaga cgctgttata tcactgctgg ctgatacgaa 1649281 tgctgatcag attgagggag acaagggaaa agaaaccttt aagaaggaac taaaagataa 1649341 aataaatagc tacctccaag aaggaaaagt agaaaaagtg tatattacct cctttaatct 1649401 gcaataaagc ataatttgac agaatacgga ggtgaggaaa atgtcaggag aagttctctc 1649461 ccaaaatgaa atagatgcac tgctctctgc aatatcaact ggtgaaatgg acgctgaaga 1649521 gctgaaaaaa gaagaaaaag agaagaaagt caaggtttat gatttcaaac gtgcgctgcg 1649581 gttttctaag gatcagatcc gcagtttaac gagaattcat gacaattttg caagacttct 1649641 taccactcat ttttctgctc agctcagaac ctatattcac atatctgtca gttctgttga 1649701 tcaggttccg tatgaggaat ttatcagatc gattccaaac atgacgattc tgaatctatt 1649761 tgatgttcat ccgatggaag gaagaattat gatggaggtc aaccccacga tagcttatac 1649821 gatgatggat cgagtcatgg gcgggattgg aatcagtcat aacaaggttg acagtttgac 1649881 agaaattgaa acaaaaatca tttctaattt atttgaaaat gcactgggta attataaaga 1649941 agcttggcag tcaattgctg atattgaacc ggaaatgact gagtttgaag tgaatccgca 1650001 atttgttcag atggtatctc ctaatgaaac agtcgtggtg atctcgctca atactcaaat 1650061 tggtgaaatc agcggtgtca ttaatctctg tatcccgcat attgtactcg agccgctcat 1650121 accgaagctt tcagtccact attggatgca atcagaccga aatgagccaa agcctgagga 1650181 aacaaagtcg cttgaaaaac gtatcatgac agcacaaata cctgtcgtgg ccgagctcgg 1650241 cacatctgaa ctgacgatag aagagttttt aagtttagaa gtcggagact gcataacttt 1650301 ggacaaatca gtcacggatc ctcttactgt attggtcgga gataagccga aatttttagg 1650361 acaagccggc cgggtgaatc gaaaacaggc agtgcaaatt ttagatcacg acataagagg 1650421 tgaacaagat ggagaataat agattatctc aagatgagat tgacgcgctt cttaacggta 1650481 ctggcagcac gcttgatgag ccagagattc cggaagtaga tgacttatcg gaaatggagc 1650541 gtgatgcgat cggtgaaatc ggtaatattt cattcggcag ttctgcgaca gcactgtcaa 1650601 cgcttttaaa tcaaaaggtc gatattacga ctccaagcgt aacggtcatt ccaagaagta 1650661 aaatcagcga tgcgtttcct gaaccgtatg tagcgattga agtgaattat acggagggct 1650721 tcagcggaag caacctgtta gtcgtggaac aaagtgacgc ggcgatcatt gcggacttaa 1650781 tgatcggggg agacggaaaa ggtgcggacc cttcactggg tgaaatccat ttaagtgcgg 1650841 ttcaagaagc aatgaaccaa atgatgggat cggctgccac atcaatgtct actgtattca 1650901 gtaaaaaaat tgatatttca cctcctcggg ttgaattgct ggatgttact gaagaaaagg 1650961 gtacagaccg tattcctgat gatgaaatgc tggtgaaagt ttctttcaac ttaaaggtgg 1651021 gagaattaat agactccagc attatgcaac tttacccatt gacatttgcg aaagatttaa 1651081 tttcaagcct tatgaactca gaaagtgcag aggaagaaga aacggtgcag cctgaagtta 1651141 catacgaaca gccgaaagag cctgtgacgc cagagccgcg tattgaaccg aagcaacagc 1651201 agcagccgcc aaaaaggcag ggaacagcaa aaaaagcagc gccagttcag gtttcaccgg 1651261 tggaattttc cgcgtttgat ccaaacgaag ctgtacaagc ccctattcat aatctggata 1651321 tgcttttgga tatcccgctt tcgattactg ttgagcttgg cagaacgaag agaagcgtaa 1651381 aagagatttt agagctttct gccggaagta ttatcgagct tgataaatta gccggtgagc 1651441 ctgtagatat tttagttaat cagcgtatcg ttgccaaagg cgaggtcgtt gtcattgaag 1651501 aaaacttcgg agtgagagtc actgacattt taagccaggc agagcgcatt aataatttaa 1651561 aataacgaaa cacaaggaga gagatagatt atggcacata gaattttaat tgtagatgac 1651621 gcagcattta tgcgaatgat gattaaagat attttggtta aaaatggttt tgaagttgtg 1651681 gcggaagctg aaaatggagc acaagcggta gagaaatata aagagcattc acctgacctt 1651741 gttactatgg atatcacgat gccagaaatg gatggtatta cagcattaaa agaaattaaa 1651801 caaattgatg cgcaggcaag aatcatcatg tgttctgcta tgggacagca atcaatggtt 1651861 attgatgcca ttcaggccgg cgctaaggat ttcattgtga aacctttcca ggctgaccgt 1651921 gtgcttgaag caatcaacaa aacattaaat taaagggtgt acgactgttg aaaaagagtc 1651981 aatattttat tgtttttatt tgttttttcg ttttattcag tgtacatccg attgctgctg 1652041 ccgcggcaga ctctgataat tcaactgtaa acgaatggtt tcaaaagaaa gatgaaaaaa 1652101 ctgcagatca atcagagcaa aagaaagaaa aaacaacaaa aactgctgat gagacggagg 1652161 gagcggctgc tccttctgtc tcagcttttg attttgtaaa gatgattttc gctttactgt 1652221 ttgttatcgt gctgatttac gggctggtta agctcatgaa caaaagaaat cggctcctaa 1652281 agccttttca atatgttgaa aatattggcg gcacatcggt cggtcagaac agatccatac 1652341 aattgatcaa ggtcgggaaa agtgtgctcg tcgtcggtgt aggagagacg atccagctgc 1652401 tgaaagaaat tgaggatgaa aaagagattg aagtcattct cagtcagcat gaagaggcaa 1652461 tgtcaagcaa aatagagtgg caaaagtttg tgaagccgct taagagttct gaacatcagc 1652521 cgcagcaaaa actgccttca ttttcaaaag cattaaaaga gcaacttgaa gagttaaaac 1652581 aaaaccgttc tgaaggaaag aagaaaggcc cacgtcatca tgaatgagtt tataaatatt 1652641 ttcagttcaa gcgatccgga aaacgtaagt tcgactgtta aattactatt attgttaact 1652701 gtattttcag tggcgcctgg aatattgatt cttatgactt gttttactcg catcgtcatt 1652761 gttctgtcat ttgtcagaac ttcacttgcg acgcaatcta tgcccccaaa ccaggttcta 1652821 atcgggcttg cgctgttttt aacatttttt attatggctc ctactttttc agaaattaat 1652881 aaagaagcgc tgaccccatt aatggacaac aaaatcagct tggatgaagc gtatacgaaa 1652941 gctgaggaac cgattaaaga atttatgagt aaacacacaa ggcagaagga tctggcgctg 1653001 tttatgaatt acgcgaaaat ggataaacct gaatcattaa aggatattcc gttaacaaca 1653061 atggttccgg cttttgccat atcggagctt aaaacagcat ttcaaatagg ttttatgatt 1653121 tttatccctt ttttaattat agatatggta gtggcgagcg tcttgatgtc aatgggaatg 1653181 atgatgctgc ctccagttat gatttctctg ccctttaaaa tattactttt tgttttggta 1653241 gacggctggt atttaattgt gaaatctttg cttcagagct tttagggtag gtgctaaacg 1653301 tgagttcaga atttgtaatt tctatggcgg aaaaagccgt atacgtaacg ctgatgatca 1653361 gcgggccatt attggctatt gctttactgg tcggtttaat tgtcagcata tttcaggcga 1653421 caactcaaat ccaggaacag actttggcgt ttattccgaa aatcgtggcg gttctcctgg 1653481 ctctcatttt ttttggtccg tggatgctgt cgacgattct ttcatttaca acagagctgt 1653541 tttctaattt aaatcgtttt gcagggtaat gtagagatga attcaattat tgacttattt 1653601 cctgcttttt tattggtttt tattagaatc tctgcttttt ttgtaacgat tccgctattt 1653661 ggacatcgaa atgtgccagc tgttcatcgc ataggttttg ctttttttct tgcggtcatt 1653721 tgtttcagca ccattgataa accgccctct ttggagatag atgagcacta tatgcttttg 1653781 gcgtttaaag aagctttggt cggcctatgt ctgggtttaa ttgcttatat gatgattgcc 1653841 gcagtgcaga ttgccggctc gtttattgat tttcaaatgg gattttcaat agcaaacgtt 1653901 attgatccgc aaaccggtgc acaaagtccg ttgattggcc agtttatcta tacgatggca 1653961 cttttgttta tgctgagtgt caatgcccac catttgttgc tggatggtat ttactacagc 1654021 tttcagtata tttcagttga tcaggcattt ccgaatttcg gcgatgaaaa gtttgcctat 1654081 tttattgcga aaagctttaa tgcaatgttt attatcgctt ttcaaatgtc agcgccggtt 1654141 gtggccagtt tgtttctagt tgatttagca ttaggtatcg tggctcgaac tgttccgcag 1654201 ttaaatgtat ttgtggtcgg tctgccttta aagatcgctg tcagtttcat tatgctcatt 1654261 gtatgtatgt ccgttatctt cgtcgttgtc cggaatgttt tcagtttaac gattgaaacg 1654321 atgcggaatc ttttagcatt ggtcggtgtt tcttaatgaa gcttagagtt gacctgcagt 1654381 tttttgcggg agagaagaca gaaaaagcca ctccgaaaaa acggaaggat acgcgaaaaa 1654441 aagggcaggt agccaaaagc tcggatgtca ataccgccgt ttctttactg gtaatattcc 1654501 tttcgcttat tgcaattggt ccgtatatga gagacaggct gctgtcattc atagaaacat 1654561 tttataccga atcgctcaca atgaagctct cagaatcaaa tgtgcataca ttgtttgtca 1654621 gcttattaaa ggatatgggc atgatactcg caccgatctt gcttgttgct cttgttgcag 1654681 gagtcgtaag caactatatg caggttgggt tcttgttttc tgctgaagtg atacagccta 1654741 agcttgaaaa actggatccg atcaaaggct ttaaacgaat atacagtatg agggcgattg 1654801 tagagctgat taaatcaatt ttgaaaatcg tagtcgtcgg ttttgcggct tttgctgtgc 1654861 tttggctgca ttatggagaa attctccggc ttcctctcct gacacccgaa gaggcacttt 1654921 ctttcgtttc aaaactcact ttgtggatgg gactaagcgg tgcaggtgca ttgttgattc 1654981 ttgctggtct cgactattta tatcagagat ttgactatga gaaaaatatc aaaatgtcaa 1655041 aacaagatat aaaagatgag tacaaaaaat ctgaaggaga cccgattatc aagtctaaaa 1655101 ttaaacaaag acagcgggaa atggcgatga ggcggatgat gcaggaagtt ccaaaagcag 1655161 atgtcattat cacaaacccg actcactatg cgattgcttt gaaatatgat gaagaaaaaa 1655221 tggacgcacc ttatattgtt gcaaaaggcg tcgaccacct tgcgttaaaa atcaggaaaa 1655281 ttgctaaaga gcatgatgtc atgatggtag aaaacagacc gcttgcccgt gcgttatatg 1655341 atcaagtgga aattgaccag gcagtgccgg aagaattttt taaagtttta gcagaaattc 1655401 tggcttacgt atataaaaca aaacaaaaag tatattgaat ttttcgattt aaaaggagag 1655461 aaaaaacagc atgtcaacaa gagatttatc cgttttaata agtgttgtcc tcattgtggc 1655521 gatgctggtg attccatttc ctccatggct gttaagtatt ttgatcatta ttaatatttc 1655581 tcttgcgttg atcgtgcttc tcaccacaat gaatatgcag gaagcgcttc agttttcgat 1655641 ttttccgtca ctgttgctgc ttttgaccct atttcgtttg ggcttgaacg tctcaactac 1655701 ccgttcaatt ctttcacacg gtgagggagg taaagtcgtc gagactttcg gaaatttcgt 1655761 tgtcggcgga aatgtattag ttggactcgt tgtatttatc atccttatta ttattcagtt 1655821 tatcgtcatt acaaaaggtg ctgaacgtgt ttccgaggtt gcagcaaggt ttacgctgga 1655881 cgcaatgccg gggaagcaga tgagtattga tgctgattta aacgcaggga tgattaccga 1655941 acaggaagcg aagcatcgcc gcgaaaaagt ggcaagagaa gcagactttt atggagcaat 1656001 ggacggtgcc agtaaatttg taaaaggtga cgccattgcc ggaatcatca ttgtgatgat 1656061 caatattatt ttcggaatcg tgatcggaat gcttcagcag ggcatgtcca ttcaagaagc 1656121 tgcttcacac tttacgatgc tgactgtagg ggatggaatt gtttcgcaaa tcccggcact 1656181 gttaatttct acggctacgg gtattgtggt cacaagagct gcatctgaag gaaacttagg 1656241 gcatgacatt acaggccagc tgtttgcgta tccaaagctt ttatacgtcg cagcagctac 1656301 gatcatgctt ttaggtattt tcactccgat cggcatcctt ctgacggggc cgcttgcggg 1656361 attgcttgct tttggcgcat atacactatc taaatcaggt aaggaaaaag aagaagtgga 1656421 tgagattctt gaggaagagg ctgaggtgga cgagcttaaa agccctgaaa gtgttgttca 1656481 gcttctgcat atagatccga tagaatttga gtttggatat ggcctgatac cgcttgctga 1656541 tgccaatcaa ggcggtgatt tattagaccg aattgttatg atacgccgtc agttggcttt 1656601 ggaactcggg cttgtcattc ctgtcgtgcg aatcagagat aatatagcgt tgcagcctaa 1656661 tgaataccga ttgaaaatta aaggaaacga agtagcaaaa ggcgagctgt tgcttgatca 1656721 ttatttagcg atgtcgccta ctcctgagga cgatctcatt gaagggattg aaacagtgga 1656781 gccttcattc ggactgccgg ctaaatggat tagcgaagcg gtaaaggatg aagccgacat 1656841 gcttggttat acagtagttg atcctgcatc agtcgtttca acgcatatta cggagaaaat 1656901 taagcagcat gcccacgaat tgatcggaag gcaggagaca aaacagctga tcgatcactt 1656961 gaaagaatcg tatccagtcc tggttgaaga ggttacgccg aatccattgt ctgtcggtga 1657021 tattcagaaa gtgcttgcta agcttttaaa agaaaaagtt tcaattcgaa acttagtaac 1657081 gatttttgaa acacttgctg actatgggaa attaacaaca gattctgatc tcttgacaga 1657141 gtatacaaga caagcgcttg ctaaacaaat tacagcccag tttgccaaag aaaatgaagt 1657201 gttgaaggtt gttacttgtt ccggccgtgt agaaaaagca atagcagacg gtgtgcagca 1657261 gacggaacac gggaactatt tatcacttga accagatatt tcagaaagta tagtgcgctc 1657321 tgtcgccaaa gaagctgaac agctctcatt acgtcaggaa accgcgattc ttctttgctc 1657381 gccgcctgtc agaatgtatg tgaagcagct actggaacgg tacttccctg atcttccggt 1657441 actctcttat aacgaacttg aggcgaatgt tgaggtacaa agcattggag tggtggatat 1657501 ttaatgaaaa taaaaaaatt tactgctgct tcaatgcaag aagcggcact tctcatcaga 1657561 aaagagttag gtaatgaagc ggtcatatta aattcgaaaa aaattaaaaa gcgaaaatgg 1657621 tttggcctcg tcaacaagcc tgctgttgaa gtaatcgccg tattggatca ggactttctt 1657681 gagaaaaaaa cgcctcagaa ggcagctgaa ccgaaacaaa cattaaaaac tccggtcagc 1657741 agtccaaaaa tagaggagag aacatatccc cctcaaattc cggcgcaaca ggagctaggt 1657801 gatttttcag catatcaatc tgtacttcct gagccgctgc gaaaagcaga aaagcttttg 1657861 caagaaacag ggatcaaaga gtctacgaaa acgaacactc tgaaaaaatt gcttcgcttc 1657921 tctgttgaag caggcggctt gactgaagaa aatgttgtcg gcaaacttca ggaaatacta 1657981 tgcgatatgc tgccctcagc agacaagtgg caggagccaa ttcattcaaa atatatcgtt 1658041 ctctttggtt caacaggggc tggtaaaaca actacactgg ctaaactcgc agccatatct 1658101 atgcttgaaa aacataaaaa aatcgctttt attacaacag atacgtatcg tattgcagct 1658161 gttgaacagt tgaaaacata cgctgaactg ctgcaggctc ctctggaagt ttgctataca 1658221 aaagaagaat ttcagcaggc gaaggagcta ttttctgagt atgatcatgt gtttgttgat 1658281 acagctggaa gaaacttcaa agacccgcaa tacattgatg aactgaaaga aacgattcct 1658341 tttgagagca gcattcagtc atttcttgtt ttatccgcga ctgcaaaata tgaagatatg 1658401 aagcatattg tcaaacggtt ttcatccgtc cctgtcaatc agtatatttt tacgaaaata 1658461 gatgaaacga cttccttagg ttctgtattt aatatactgg cagaatcaaa aataggtgtc 1658521 gggtttatga ctaacggcca gaatgtgcct gaggatatac agactgtatc tccacttggt 1658581 tttgtgagga tgctgtgcag atgaacagat atgaccaagc agcaacttta cgggcgaaaa 1658641 tggaaaaacg tgagcgcgtt ctgccaatgg tttattcaca aaaagcgaag acacttgctg 1658701 tcatcagcgg caagggcggt gtcggaaaat ccaatattac cttaaatatg gcacttgcgc 1658761 tgcaggataa aggtaagaag gtgctgctca tcgaccttga tatcgggatg gggaacattg 1658821 atatattaat aggaaattca tcgtctgcca cgataatcga tgttttaacc gatcgtaagc 1658881 ctttgctgca gtcattatcc gttggcccaa agggtttgcg gtatatatca gggggaaccg 1658941 gtcttgatgt gatgtttcag ctcgatcaga gaaaatggac gttttttgcc aatgaacttt 1659001 ctcatgcatt aagccagttc gattatgtgc tgtttgacat gggagcaggc ttatcaaaag 1659061 atcaactgcc ttttatttta tcagcagaag atattttgat tattacaact cccgagccga 1659121 cggccattat ggacgcatac agcgctgtca agcacttggt tttgacagaa aataagcttt 1659181 caatgaaggt ggctgtcaat cggtgccgtg accaaaagga agggcttgac gcttttgccc 1659241 gcctctcccg tacaattcat atgtttttgg atgttcaggt tcagtttgcc ggttccgttt 1659301 ctgacgatgt gatcgtgagc aaagcggttg tcgaacaggt tccttttttc ataaaaagcc 1659361 ctcaggcaaa agccagccgg tcagtccgta ttttagcgga cgccttgttt gaaagagaag 1659421 aaacgagaca caaagaagac aaacagacat ttattgagaa attatcttct tttttaatga 1659481 ggagggctta atttgattcg tgtgcttgta gttgatgatt cagcttttat gagaaaaatg 1659541 ataagtgatt ttctgaccga agaaaagcag atagaagtaa tcggaactgc gagaaacgga 1659601 gaagaagcgc ttaagaagat tgaattatta aaaccggatg ttattactct tgatgttgaa 1659661 atgccggtca tgaatgggac agatacgctc cgcaaaatta ttgagattta taacttgccg 1659721 gtcattatgg tgtctagcca gaccgagaaa ggtaaagaat gcacaattaa ttgtttggag 1659781 atcggtgcct ttgactttat cacaaagcca tcaggctcaa tatctctgga tctatacaaa 1659841 attaaagaac aactagttga gcgtgtcgtc gcggcaggac tttccggcaa gcggaaacgt 1659901 cctgtttccc agacagttcg gcccgaacct attgtgcgtg ctgtcgttaa gcctgaatta 1659961 agcaaaccga aacctggcac gggcagacaa attgtgtgta tcggcacatc aacaggcggt 1660021 ccacgggcgt tacaaaaggt gataccgaag ctccctaagg atttgaacgc accagtggtt 1660081 gtcgttcagc acatgcctga agggtttact gcttctttgg ctgatcggct gaatcattta 1660141 tctgacattc aggtaaaaga agcaaaagat ggtgaagcag ctcttaacgg ctgtgtttac 1660201 atagcaccgg gcggaaaaaa catatccgtt attaaaaaca gcgaaggact ccaggttgtg 1660261 cttgataacc atgacacacc aagccgtcat aaaccatctg ctgattattt attccgttct 1660321 gtcgggaaac tgacagatta tgaaaaagta gcggttatca tgaccggaat gggcagtgac 1660381 ggcactgctg gactaaagga catgctaaca gccggcaatg tgaaagccat tgcggagtct 1660441 gaagaatctt gtgtcgtata cgggatgcca aaagctgctg ttaaagcggg tctcattcat 1660501 gagattaaac atgtggaaga tatcgcagca tccatcacaa gctgtgtgaa aaaagagagg 1660561 gtgtgattca aatggatatg aatcagtatt tagatgtctt tattgatgag agtaaagaac 1660621 atttacaaac atgtaatgaa aagcttcttc ttttagagaa agacccgact gatcttcagc 1660681 tcgtacatga tatattcagg gctgcccata cattaaaagg aatgagcgca acgatgggct 1660741 acacggattt agcacatctt acccatctgc ttgaaaacgt gctggatgca atccgaaacg 1660801 gagacatgga agtcacctca gactggctgg atattttgtt tgaagctctg gatcacctgg 1660861 aaacaatggt tcagtctatt attgatggcg gggatggtaa aagagatatc tcagaagtga 1660921 gtgccaagct tgatgtgaat ggtgcgcacg ctgaatccgc tgcctccgct gaacctgcag 1660981 aagcacagag ttcagcatct gattgggaat atgatgaatt tgaacgcaca gttatacaag 1661041 aagcggagga gcaaggcttc aaacgatatg aaatcaagat ttctctgaac gaaaactgta 1661101 tgttaaaagc agttcgtgtc tatatggtgt ttgaaaaact aaatgaagtc ggagaagtag 1661161 ccaaaacaat tccaagtgct gaagtgcttg aaacagaaga ttttggaact gactttcaag 1661221 tttgtttctt aacacatcaa tcagcggaag acattgaaca attaatcaat ggcgtgtcgg 1661281 aaattgagca tgttgaagtc attcaagggg ctcctttaac atcagctgaa aagcctgaag 1661341 aatctaagca agaagattca ccagcagcag ctgtacctgc gaagcaggag aaacaaaaac 1661401 agcctgctaa aaacgatgaa caggcgaagc attcagccgg cggatctaaa acaattcgtg 1661461 tcaacattga caggcttgat tctttaatga acttatttga agagcttgtc attgaccgcg 1661521 ggcgtctcga gcagattgcg aaagagcttg agcataatga actgactgaa acggttgaac 1661581 gaatgacgag aatttccgga gatttgcaat cgattattct gaatatgaga atggtcccgg 1661641 ttgaaactgt ttttaacaga ttcccgagaa tgattcgcca gcttcagaaa gagctgaata 1661701 aaaaaattga actctcgatc atcggtgcgg aaactgaact ggatcgtaca gtaattgatg 1661761 aaatcggaga tccactcgtt cacttgatca gaaacagtat tgaccatggt atcgaggcgc 1661821 cggaaacacg tttgcaaaag ggaaaaccgg aatcaggaaa agttgtgctt aaagcttatc 1661881 acagcggcaa ccatgtcttt atcgaagtag aggatgacgg cgcaggcctt aatcgaaaaa 1661941 aaattctgga aaaagcgctt gagcgcgggg tcataacgga aaaagaagct gaaaccttag 1662001 aagacaacca aatttacgaa ttgatttttg ctccggggtt ctcaactgct gaccaaattt 1662061 ctgatatttc cggccgcggt gtaggacttg acgttgtaaa aaacaaactg gagtctcttg 1662121 gcggttcagt cagtgtgaaa tcagccgagg gtcaaggctc tctattcagc atccagctgc 1662181 cgcttacctt gtctattatt tcagttctgc tgattaagtt ggaagaagag acatttgcca 1662241 ttccgatttc ttcaatcatt gagacagcag ttattgacag aaaagacatt ttgcaaacgc 1662301 atgaccgtga agtgattgac tttagagggc atattgtccc tgtcgtttat ttaaaagaag 1662361 agtttaaaat agaagataca agaaaagatg cggaacagct ccatatcatt gtcgtgaaaa 1662421 aaggcgacaa acctactgca tttgtggtgg actcctttat tggccagcag gaagttgtgc 1662481 tgaaatcact cggagattat ttaacaaacg tctttgcaat ttccggagct actattttag 1662541 gagacggaga agtagcgctc attattgatt gtaatgcact gattatttaa ccattcgagg 1662601 aggtgtctca catgactgca gaaattaaaa caggcgaaaa aatgatagtc tttatggtaa 1662661 atggcaaaga atatgccatt tccgtcactc aggtgaaatc aattgaaaaa tggcaaaagc 1662721 caacgagggt acctggcgtc gaaccatata tttgcggggt aatcaattta cgcggggtgg 1662781 tgactccggt tattgattta agaaaacgcc tgaatttgcc agagtatgaa attacagatg 1662841 aaacacgaat tatcattatt gcttatcgtg atattgaagt cggctggatt gtggatgaag 1662901 cgaatgatgt gattaccgta cacgaaagtg aaatagaatc tgctccagaa ggcgttcaga 1662961 aagatacgga tgtgtcgatc gaacagattg tgaaacaaga gaacagactc ttaaatatta 1663021 ttgatgcgaa cgcggttttg gataaagaat catctcagtc cgctgtgccc gatcaagctt 1663081 aatcttaaag gggttatgac atgagtattt ttaatggaat caaagaagag cagatggaca 1663141 ttttgcggga agtcggcaat ataggcgccg gccactccgc ctctgcaatg gcccagctgt 1663201 taaatagaaa gatagatatg gaagtcccat ttgcaaagct gctgtctttt gatgagcttg 1663261 ttgatttttt cggcggcgcc gatgtcccgg ttgccagcat ctttttaaga atggaaggcg 1663321 atttaacggg ttcaatgttc tttataatgc ctttttttca ggcggagcag tttatcagag 1663381 agctgattgg aaaccccgat tttgacatag aggacttagg tgaagaccac atgagctcat 1663441 ccgctttgca tgaactgggc aatattttag cggggtcata tttaacagct ttggcggatt 1663501 tgacgaaact ccagctctat ccaagtgttc ctgaagtctc attggacatg ttcggagctg 1663561 tgatcagcga agggctgatg gagctcagtc aggttggaga acacgccatt gttgtcgaca 1663621 cgtcaatttt tgaccaaagc catcagcagg agctgaaagc gcatatgttt atgctgccgg 1663681 actatgattc atttgaaaag ctctttgtcg ccttaggtgc atcattatga gtacaactga 1663741 ggctgttgtt ataaaggttg ggattgctga cgtgaagatc gcccgcttcc cggataccat 1663801 ccggacctct ggtttgggct catgtgtggg gctggtgctt tatgataaag aaaagcaaac 1663861 ggcgggtctt gttcatgtca tgcttccgga ttcgacgtta tcgaaaactg ccgagctcaa 1663921 ccgggctaag tacgctgaca ccgccgtaca gaccacgatt gatatgctga tagaagcggg 1663981 atgccggaaa tttgcattaa aagcaaagct ggccggcgga tcagagatgt ttaaatttaa 1664041 atcgacaaat gatttgatga agatcggacc gagaaatgta ttagcgataa aagaacagct 1664101 gtctttattt aatattccta ttattagtga agatacgggc ggctcaagcg gccggacgat 1664161 agaatttgaa ccgaagtcct gcatgctgca tattcgaact gttaaacaag gtgaaaaaac 1664221 gatttaatta aggtattagg gggataacaa tgcaatcctt gaattatgaa gatcaggtgc 1664281 tttggacgcg ctggaaagag tggaaagatc ctaaagccgg tgacgactta atgcgccgtt 1664341 acatgccgct tgtcacatat catgtaggca gaatttctgt cggactgccg aaatcagtgc 1664401 ataaagacga tcttatgagc cttggtatgc ttggtttata tgatgccctt gaaaaatttg 1664461 accccagccg ggacttaaaa tttgatacct acgcctcgtt tagaattcgc ggcgcaatca 1664521 tagacgggct tcgtaaagaa gattggctgc ccagaacctc gcgcgaaaaa acaaaaaagg 1664581 ttgaagcagc aattgaaaag cttgaacagc ggtatcttcg gaatgtatcg cccgcggaaa 1664641 ttgcagagga actcggaatg acggtacagg atgtcgtgtc aacaatgaat gaaggttttt 1664701 ttgcaaatct gctgtcaatt gatgaaaagc tccatgatca agatgacggg gaaaacattc 1664761 aagtcatgat cagagatgac aaaaatgttc cgcctgaaga aaagattatg aaggatgaac 1664821 tgattgcaca gcttgcggaa aaaattcacg aactctctga aaaagaacag ctggttgtca 1664881 gtttgttcta caaagaggag ttgacactga cagaaatcgg acaagtatta aatctttcta 1664941 cgtcccgcat atctcagatc cattcaaagg cattatttaa attaaagaat ctgctggaaa 1665001 aagtgataca ataatgaatt tcatggttag cgagtgaaaa acatgtcaac actattatgg 1665061 cttttaagct ttatgctcca cggcgttctt ctgtacgctg tcattatcct gtatacgagg 1665121 ctcgctgcag tgaaagaaac agaaaaacag caaaaacaga tacttgaaga gacggaaaac 1665181 accttggcgg catttctgct tgaattaaaa gaagaaaatg agaaactgat agaaaataaa 1665241 gcttcatctg caagtcaatc agatgaagaa tcccaaaagt caggccttca gacctctgaa 1665301 acatatcaag agcgggatcc agtccaagag gcagagaatc ttcctgaaca tattgaaggt 1665361 ctgattacag aggttgaccg tcgggaagag ctcgtaaaca gtgaggtcca atcatttgaa 1665421 gaccaggtca tagaattata tgaacaggga tattcggcaa gtcaaattgc ccagaaaatg 1665481 aagagcggaa agacagaaat cgagctattt ttaaaatttc gctccaaagg tgtaaaggat 1665541 tcttgattgt cggataaagc tgtgttatat tatgtcttgg tgttaaatac acacgcttaa 1665601 cgatttatgc agagggtgct gcaggcggca gttctgtaca aaaatgacct aagcggagga 1665661 aaaaaaccat tatattagga ggaaataaca tgtcagtcat ttctatgaag caattgcttg 1665721 aagctggtgt tcacttcggt caccaaacac gccgttggaa cccaaaaatg aagcgttaca 1665781 ttttcacgga gcgtaacgga atctacatca ttgaccttca aaaaacagtc aaaaaagtag 1665841 aggaagctta caacttcact aaaaatcttg ctgctgaagg cggaaaaatc cttttcgtcg 1665901 gaacaaaaaa acaagctcaa gattctgtta aagaagaagc tcaacgctct ggcatgtact 1665961 atgtcaacca acgctggttg ggcggtacat taacaaactt cgaaacaatc caaaaacgta 1666021 ttaaacgtct taaagacatt gaaaaaatgc aagaaaacgg tacgtttgat gtacttccta 1666081 aaaaagaagt cgttcaattg aaaaaagaat tagagcgtct tgaaaaattc ctaggcggaa 1666141 ttaaagatat gaaggatctt cctgatgcat tattcatcat cgatcctcgc aaagagcgca 1666201 tcgctgttgc ggaagctcgc aaattaaaca tccctatcat cggtatcgta gatactaact 1666261 gtgatccaga tgaaatcgat gttgttatcc cagcgaacga tgacgctatc cgcgctgtta 1666321 aacttctaac ttctaaaatg gcagatgcaa tcttagaagc gaagcaaggc gaagaagaag 1666381 cggaagttgc tgaagaaact gcaccagaaa cagaaacaac aactgcgtaa cctattcaaa 1666441 aggtgataag agggactgcc ttttatcacc ttttttcaag aaaaatgtgt aatatacata 1666501 ctcttgttta aacatataag gaggaataca aatggcaatt actgcacagc aagtaaaaga 1666561 actgcgtgaa aaaactggcg cgggcatgat ggattgtaaa aaagcgttaa ctgaaactga 1666621 cggagatatg gacaaagcaa ttgacctttt aagagaaaaa ggaattgcaa aagcagcgaa 1666681 aaaagctgac cgtatcgcag cagaaggttc tactcttatt aaaactgacg gcaacaaagg 1666741 cgttatccta gaagtaaact ctgaaactga tttcgttgcg aaaaacgaag gttttaaaga 1666801 gcttcttaac actttagctg accaccttct tgcaaacacg ccagctgatg ttgaagaagc 1666861 aatgggccaa aaaatggaaa atggctcaac tgttgaagag tacatcacaa gcgcagttgc 1666921 taaaatcggt gagaaaatca ctcttcgccg ctttacagtt cttacaaaag acgacagctc 1666981 tgcattcggt gcgtaccttc acatgggcgg ccgcatcggt gtattaactg ttctcaacgg 1667041 tacaactgat gaagaaactg cgaaagatat cgcaatgcac gttgctgcag ttaaccctcg 1667101 ttacatttct cgtgatcaag tatctgaaga agaaacaaat catgagcgtc aaatcttaac 1667161 tcagcaagcc ctccaagaag gcaaacctga aaacatcgta gcgaaaatgg ttgaaggccg 1667221 tctgaacaaa ttcttcgaag aaatttgtct attagaccaa gcgttcgtta aaaacccaga 1667281 tgaaaaagtg aaacaagtta ttgcagcgaa aaacgctact gttcaaactt ttgtccgcta 1667341 tgaagttgga gaaggcatcg aaaaacgtca agaaaacttt gctgaagaag taatgaacca 1667401 agtgaaaaaa taatggtgaa aagatttcgc ggctaagtcg cgtcttttca ggcagtatag 1667461 gggacacatt ttgtgttccc tatttttaaa actatattta caaacctttt tttctcttgc 1667521 ataatagaaa acggcaatgt ttacacttgg aggttatcat ggaaaaacca aaatacaaac 1667581 gtatcgtatt aaagcttagc ggggaagcat tggcaggaga acagggaaat ggaattaacc 1667641 cgactgtcat tcaatccatt gcaaagcaag tgaaggaaat cgctgagctt gaagtcgaag 1667701 tggctgttgt tgtaggcggc ggcaacttat ggcgcggaaa aacaggaagt gacctgggca 1667761 tggaccgcgc gactgctgac tatatgggaa tgctggcgac agtaatgaat tcgcttgctc 1667821 ttcaagacag cttggaaaca ctcggaatcc agtccagagt gcaaacatcc attgaaatga 1667881 gacaagttgc tgaaccgtac ataagaagaa aagcgatacg ccacttagag aaaaaacgtg 1667941 tcgttatttt cgctgcgggc acaggaaacc catatttctc aactgatacg acagctgcac 1668001 tgcgggctgc tgaaattgag gcagacgtta ttttaatggc taaaaataac gttgacggtg 1668061 tgtataatgc tgatcctaga aaagatgaat cagctgttaa gtatgaatca ctttcttatc 1668121 ttgacgttct taaagacggc ctggaagtca tggattcaac agcttcctct ttatgcatgg 1668181 acaatgacat tccgcttatc gtcttttcta ttatggaaga aggaaatatc aaacgtgccg 1668241 ttatcggtga atcaatcgga acgatcgtga gggggaaata acgtgtcaaa agaagtatta 1668301 actcaaacaa aagaaaaaat ggaaaaagca attgctgctt atcagcgcga attggctact 1668361 gtacgcgcag gccgtgcaaa tccatcatta ttagataaag taacggttga atattacgga 1668421 gcgcagacac ctttaaatca gttgtcttct attaacgtgc ctgaagctcg tatgctcgtt 1668481 atcacgccat acgataaaac agcaatcggt gatatcgaaa aagcgatttt aaaagctgat 1668541 ttaggtctta caccaacaag tgacggcaat atgattcgaa ttgcaattcc ggcactaaca 1668601 gaagagagac ggaaagaatt agtgaaagtt gtaaaaaaat atgctgaaga agcaaaagta 1668661 gctgttcgta acgttcgccg tgatgctaac gatgatctca aaaaacttga gaaaaacgga 1668721 gacattactg aggatgaact gcgtgcttcc actgaagacg ttcaaaaact gacagatgaa 1668781 tatgtgtcaa aaattgacag tgtcacaaaa gacaaagaaa aagaaatcat ggaagtttaa 1668841 tgaaaaacta tgtacaatag ataatagtga aaagaccctc tcatgtttac agggggtttt 1668901 tttgttaata ctgttgatta cattgattat cagcagggaa tgtaaccttt ttgggtgacg 1668961 gaggaatctc atgctcaaca tactcaaaaa ttggaagaat cagcaaactg cggcttccaa 1669021 cttagaacgt tatacaaaag aagacatact taagggagaa attcccgaac acatcgccat 1669081 tatcatggat ggaaatggcc gttgggctaa aaaacgctct cttcccagaa ttgcaggcca 1669141 ccatgaaggg atgaaggtgg taaaaaggac cacgaagctc gcaaacgaat taggtgtcaa 1669201 agtactgaca ttgtatgcat tttcaacaga aaactggaaa agaccgaaaa tggaggtcga 1669261 ttttttaatg aagcttccgg aagaattttt gaatacgtat cttccagagc ttgttgagga 1669321 aaatgtacag gttcggatca ttggggatga aacggctttg ccggcgcaca cattacgtgc 1669381 gattgaaaaa gctgtacagg acacggcgca aaacgacgga atgatcctta attttgctct 1669441 taactatgga ggccgtactg aaattgtcag tgctgcaaaa tcactcgcgg aaaaagtgaa 1669501 ggaaggctct ttgaatattg aagacattga tgaatcgctt ttttctactt atttgatgac 1669561 tgaatctttg caggatcctg aacttttaat tcgaacgagc ggcgagataa ggctgagtaa 1669621 ttttatgcta tggcaggttg cctacagtga atttgtcttt actgacgtct tgtggcctga 1669681 ctttaaagaa gatcacttct tgcaggcgtt aggagagttt cagcagagag gccggaggtt 1669741 tggcggaatt tagaggatgg tggacatgaa acaaagaatt ttgacaggtg ttctggcagc 1669801 aattgtattt ttatttttgg ttattgtcgg gaaattgccg ttcaccatat taatttatgc 1669861 tatgggcagt gtggcgcttt ttgaactttt acggatgaaa aagctgaagc tggtttcact 1669921 gccgggtttg atcggtcttt tattattgtg gatgttctta ttaccaagcc agtattcgtt 1669981 ttttgaagcg gacgggattt ccaaaatgga aatcgcttta tttgcggtac tgctattgct 1670041 gacttacaca gtgttggtca agaacacctt tacttttgat gaagtcgggt ttattacgct 1670101 tgcagcaatt tacatcggaa tgtgttttca ttattttatc gaaatcagaa atcttgacca 1670161 atacggatta acatacattt tttatgcgtg tgttgtcatt tggtccaccg attccggtgc 1670221 ctattttgtc ggtaaatcgc ttgggaagcg gaaactgtgg cctgaaatca gtccgaataa 1670281 aacagtggaa gggtttgcag gcggaattgt catcgcactt gtattggcga cgatttttca 1670341 gcttgttgca caacttccga tcccgtatat ctatctgctg ttgatcacgc tgtttttgtc 1670401 tgtttttgga caactgggag atttagtgga atccgccttg aaaagacatt acgatgtaaa 1670461 ggattctggg aatattcttc ccgggcatgg cggtatatta gaccgttttg acagtttctt 1670521 gtttgtcatg cctttcttgt actttctgct tgcccttttt tcataaaaaa gtctaatatg 1670581 aatatgagac tgatcatgca gcaataagaa taggagtagt ggcaactttg aaaaatattt 1670641 gtcttttagg agcaacagga tcaatcggcg aacagactct tgatgtactg cgtgcacatc 1670701 aagaccaatt tcagctggta tctatgtcgt ttggcagaaa tattgataag gccgttccaa 1670761 tgattgaggt ctttcagccg aagtttgtct ctgtcggtga tctggataca tatcataaat 1670821 taaaacaaat gtctttttct tttgaatgcc aaatcgggct gggagaagaa ggactgatag 1670881 aagcagcagt gatggaggag gttgacattg ttgtcaacgc tttgcttgga agcgtcggtc 1670941 ttatcccgac attaaaggca attgaacaga aaaaaacaat tgcgcttgca aataaggaaa 1671001 ctcttgtcac tgcagggcat atagtaaaag aacatgctaa gaaatatgat gttccgctgc 1671061 tgcctgttga cagtgagcat tcagccattt ttcaagctct tcaaggcgaa caggctaaaa 1671121 acattgaacg cctcatcatt acggcatccg gcggaagttt tcgggacaag acgcgggagg 1671181 agctcgaatc agtaacggtt gaagatgcat taaaacatcc aaactggtca atgggtgcaa 1671241 aaattacaat tgattcggct acaatgatga ataagggatt agaggtgatc gaggcacact 1671301 ggcttttcga tataccttat gaacaaattg atgtggtttt acataaggag agcatcatcc 1671361 attcaatggt tgagttccat gataaaagtg tgatcgcaca gctcggaact ccggatatga 1671421 gagtccccat tcaatatgcg ctcacttatc ctgaccgatt gccattacca gatgcgaaaa 1671481 ggcttgaatt atgggaaatc ggcagccttc attttgagaa agctgatttt gacaggttcc 1671541 gatgcttaca atttgctttt gaatcaggta aaataggagg aacaatgccg acagtgctaa 1671601 atgcggcaaa cgaagtagct gtcgctgcct ttttagctgg caagataccg tttttggcta 1671661 ttgaagactg tatcgaaaag gcactaaccc gccatcaatt actgaaaaaa ccgagcctgg 1671721 cggacattca agaagtggac aaagataccc ggggatacgt caattcaata ctcacataag 1671781 gtggtatgtt cgtgaataca gttatagcgt ttatcattat tttcggaacg ctcgttttct 1671841 tccatgaact gggccattta ttgctagccc aaagagcggg aattctctgc cgtgaatttg 1671901 cgatcggctt cggtccaaag attttttctt tcaaaaaaaa tgaaacagtt tatacgatca 1671961 ggctgcttcc ggtcggcgga tttgttcgta tggccggcga agatccggaa atgattgagg 1672021 tgaaacccgg atacacggtc gggcttctgt ttaataagga agatcaagtt gagaaagtca 1672081 tcatcaatca aaaggaaaaa tatccggatg ctttagtcat tgaagtggaa acagcggatc 1672141 tagagcatga catgaagatc accggttatg aacaggggaa agaggacgaa ctttccagct 1672201 ttactgtcag cgaaacatcc ttttttattg tagacggaga agaagtgcag attgcgccgt 1672261 ataatcgcca atttggttcc aaacctgtat ggcagcggat taaagcaatt gctgcagggc 1672321 cgattatgaa ctttatttta gcttacgtca ttttagtgat gcttgggctg attcaaggcg 1672381 taccgtcaaa tgaacctatg ctcgggcagc tgacagacaa tggacgggcg gctgaagcag 1672441 ggctaaaaga aggggattat atccaaagca ttaacggaga gaaaatgagg tcttggactg 1672501 acattgtctc cgctgtaaaa gaaaacccgg agaaagaaat ggacgttgca gtaaaaagag 1672561 ataacaaaac gcttcatatt tcggtgactc cggaagctgt taaagatgag aacaaaaaaa 1672621 caatcggacg tttcggttcc tatgcgccga ctgaaaaagg cgtactctca gcggttgctt 1672681 acggcgcgac atcaacagtt gatgtcacca aagccatttt aaccaatctg agcaaattag 1672741 taacaggcca atttaaactc gatatgctgt caggtcctgt cggcatatat gacatgacag 1672801 accaagtggc gaaaacaggg atcgtgaact tatttcagtt tgcggcgttt ttaagcatta 1672861 accttgggat tgtcaacctg cttccgattc cggcacttga cggaggaaga ctgttgtttc 1672921 tatttattga agcgattcgg ggcaaaccga ttaacaggga aaaagaagca tttgttgtgt 1672981 ttatcggagt agctttctta atgcttctta tgctggttgt cacatggaac gatatccagc 1673041 ggctgttttt gtaaacgaaa agtaaatcaa tcagaggtgc gaagaaatga gacaaagctt 1673101 gacgcttatt cctacgctcc gtgaagttcc agctgatgcc gaagcaaaaa gtcatcagct 1673161 tcttctgaga gcaggattta tcagacagaa tacgagcggg gtatacagct atatgcctct 1673221 tgcgtataag gtgattcaaa acattcagca gattgttcga gaggaaatgg agaaaattga 1673281 tgccgtagaa atgctcatgc ccgcattgca gcaggcagag acatggcagg aatcaggcag 1673341 atggtatacg tatggtcccg aactgatgag actaaaagac cgtcatggcc gtgaatttgc 1673401 tttaggggca acgcatgaag aggttatcac ttcgcttgtt cgcgatgagg ttaaatctta 1673461 taagcgtctc cctctgactc tttatcaaat tcagtctaag ttcagagatg aaaaacgtcc 1673521 tcgcttcggt ttgttaagag gccgcgaatt tattatgaag gatgcgtact ctttccatgc 1673581 atctgcagag agcctggatg aaacgtatca aaaaatgtac gaggcctatt ctaatatttt 1673641 tgcccgctgc ggcattaatg taagacctgt tatcgctgat tcaggcgcaa tgggaggaaa 1673701 ggatacgcac gaatttatgg cactttctgc gatcggagag gatacgattg cgtattctga 1673761 tgaatcacag tacgcggcta atatcgagat ggctgaagtt cttcaccagg aagttccttc 1673821 agatgaagag cctaaagctc tagagaaggt tcatacgcct aacgtgaaaa caatcgaaga 1673881 actgactgcg ttcttacagg tttcggctga agcgtgcatt aagtcagtat tgtttaaagc 1673941 tgatgaccgt tttgtcttag tgcttgtaag aggggatcat gaagttaacg atattaaagt 1674001 gaaaaacttg cttcatgcag aagttgtaga gcttgctaca catgaagagg tcattcagca 1674061 gctcggaaca gagccaggct ttgtaggccc tgtcggtatt catcaggatg tggaagtata 1674121 tgccgatcaa gctgtgaaag caatggttaa tgctgttgcc ggggcaaatg aaggagatca 1674181 tcattataaa aatgtcaatg tgaatcgtga cgcgcaaatt aaagaatttg ctgatcttcg 1674241 ttttattaaa gaaggtgatc cttcaccaga cggcaaggga acgatccgtt ttgctgaggg 1674301 aatcgaagtc ggacaagtct ttaagctcgg aacacgctat tcagaagcga tgaatgcgac 1674361 atatttagat gaaaacggac gcgcgcagcc aatgctgatg ggctgttacg gaatcggtgt 1674421 gtcaagaacg ctttctgcta ttgctgaaca gcatcacgac gaaaaaggct taatatggcc 1674481 aaaaagcgtt gcgccgtacg atcttcatat tcttgctttg aacatgaaaa acgatgggca 1674541 aagagagctt gctgaaaagc tgtatgccga tttaaaagcg gaaggctatg aagtgctcta 1674601 tgatgaccgt gctgagcgtg ccggcgtaaa attcgctgat tcagatttaa tcggccttcc 1674661 aatccgcatc actgtcggaa aacgagctga cgaaggaatc gtcgaagtga aaattcgtca 1674721 aactggtgag tcaactgaga tttcagtaga cgaattatct gcgtttatca gcaagcagta 1674781 atcaccataa cgatttatca aaaaacatgt taaaatagaa ataatagaag gtacctcatt 1674841 gcctgaggta ccttcactta tgatgttttt agggagggat actgtcttaa tggaacagtt 1674901 atcagtaaac agaaggcagt ttcaaattct tctgcagcag attaatatga cagatgatac 1674961 cttcatgaca tactttgaac atggcgagat taaaaagctg acaattcaca aagcttctaa 1675021 gtcttggcat tttcattttc aatttaaatc tttgctgcct tttcaaatat atgacacatt 1675081 aacaacgagg ctgacgcaat cgtttgccca catagcaaaa gtgacatctt caattgaagt 1675141 tcaggatgcc gaggtcagtg aaagtatcgt tcaagactac tggtcacgct gcattgaaga 1675201 actgcagggc atttcgccgc cgattatcag tcttttaaac cagcaaaaac cgaagctgaa 1675261 gggcaataaa ctgattgtca aaaccaaaac agatacagaa gcggctgcgc taaagaacaa 1675321 atacagttcc atgattcaag cagaataccg tcaatttggc tttccggatc ttcagcttga 1675381 tgctgaaata tttgtatccg agcaagaagt tcaaaagttt cgggagcaaa agcttgcgga 1675441 agaccaagag cgggctatgc aggccttgat tgaaatggag aagaaagata aagaaagtga 1675501 tgaagaccaa gcaccatctg gtcctcttgt tatcggttat caaattaaag ataacgagga 1675561 aatccgaaca cttgacagca tcatggacga agaacggaga attacggtcc aaggttatgt 1675621 gtttgatgtg gagacgcgcg agctgaagag cgggcgcacg ctgtgtatct tcaaaattac 1675681 agactataca aatagtattt tgatcaaaat gtttgcacgt gaaaaagaag atgcggcgct 1675741 gatgaagtct ctgaaaaaag gaatgtgggt aaaagcacgc ggaagcattc aaaatgatac 1675801 atttgtcaga gaccttgtca tgatcgcaaa tgacgtaaac gaaataaaag caaaaacccg 1675861 tgaagattca gcacctgaag gagaaaaaag agtggaattg catcttcatt ccccaatgag 1675921 ccaaatggat gctgttacgg gtatcggaaa gcttgtcgaa caggcgaaaa aatgggggca 1675981 tgaggccatc gctttgaccg accatgctgt cgttcaatcc ttccctgatg cgtattctgc 1676041 ggccaaaaag catggaatta aaatgattta cgggatggaa gcgaatctcg tggatgatgg 1676101 cgtgccaatt gcttataatg ccgcacatcg tctgctcgaa gaagaaacat atgttgtttt 1676161 tgacgttgag acgacaggat tgtctgctgt atacgatacc attattgagc tggctgcagt 1676221 aaaagtaaaa ggcggagaaa ttattgataa atttgaggcg tttgcgaacc cgcatcgtcc 1676281 gctttccgcc acaatcatag agctgacagg gatcacagat gatatgctac aagacgctcc 1676341 ggatgtcgta gatgtaataa gagatttcag agaatggatt ggcgatgata ttcttgtcgc 1676401 tcataatgca agctttgata tgggattctt aaatgtagcc tataaaaaac ttcttgaagt 1676461 cgaaaaagct aaaaacccag tcattgatac gcttgaactt ggacgttttc tctatccgga 1676521 atttaagaac caccggttga acacactttg taaaaagttt gatatcgagc tcacacagca 1676581 tcaccgtgcg atctatgata ctgaggcaac cgcttatttg cttctgaaaa tgctgaaaga 1676641 cgcagctgaa aaaggtattc agtaccatga tgagttgaat gaaaatatgg gtcagtccaa 1676701 tgcttatcaa agatcaagac cgtatcatgc aacattactt gccgtgaaca gcacgggact 1676761 taaaaattta tttaagcttg tgtcactttc tcatattcat tatttttaca gagtgccgcg 1676821 tattccgaga tctcagcttg agaaatacag ggaagggctt ctgatcggtt ctgcttgtga 1676881 caggggagag gtttttgagg gaatgatgca aaaatcgcct gaagaggtgg aagatatcgc 1676941 gtcattctat gattaccttg aggttcagcc gcctgaagtg tatcgtcact tgctggagct 1677001 tgaactggtc cgtgatgaaa aagcgctgaa agaaattatt gcgaatatca cgaagctggg 1677061 ggaaaagctt aataaaccgg ttgttgctac gggaaatgtt cattacttga atgatgagga 1677121 taaaatctac agaaagattt taatatcctc acaaggcggg gcaaatccgc tgaataggca 1677181 tgaactgccg aaagtgcatt tcagaacgac agacgaaatg cttgaagctt tttctttctt 1677241 aggtgaagaa aaagcgaagg agatcgtagt caccaatacc caaaaggttg cttctttagt 1677301 tgatgacatc aagccgatta aagatgattt atatacgccg aaaatcgaag gcgctgatga 1677361 agagatcaga gaaatgagct atcagcgtgc aagaagcatt tacggggaag agctgcctga 1677421 aattgtcgaa gcgcggattg aaaaagagtt aaagagtatt attggccacg gatttgctgt 1677481 tatttacttg atctctcaca aacttgtaaa acgttcacta gatgacgggt atctcgttgg 1677541 ttcccgtggt tccgtaggat cttcattagt tgcgacactt actgagatta ctgaggtaaa 1677601 cccgctgccg ccgcactatg tttgtcctga gtgccagcat tctgagttct ttaatgacgg 1677661 ttctgtcggt tctggttttg acctgcctga caagacatgc cctcattgcg gaacgccttt 1677721 gaaaaaagac ggccatgata ttccatttga aacgttctta ggatttaaag gggacaaagt 1677781 acctgatatc gatttgaact tctcagggga atatcagccg caagcacaca attacacaaa 1677841 agtattgttc ggagaagaca atgtatatcg tgcgggaaca ataggcacgg tggcagaaaa 1677901 aacagcctac ggttatgtaa aaggctatgc cggagacaac aatcttcata tgcgcggtgc 1677961 cgaaatagat cggctcgtac agggatgcac aggtgtaaaa cgtacaactg gacagcaccc 1678021 tggcggtatt atcgtagttc cggattatat ggatatttat gatttttcac cgatccagtt 1678081 cccggcagat gccacaggtt cagagtggaa aacgactcat tttgatttcc actccatcca 1678141 tgacaacctg ttaaaacttg atattctcgg acacgatgac ccgactgtta ttcggatgct 1678201 tcaagactta agcggaatag atccgaaaac aattccgacg gatgatcctg aagtgatgaa 1678261 gatcttccag ggaaccgaat cactcggtgt gactgaagaa cagattggct gtaaaacggg 1678321 cactcttgga attcctgaat tcggaacccg atttgtccgg cagatgcttg aagatacaaa 1678381 gccgaccact ttttctgagc tcgttcagat ttcaggcttg tctcacggaa ctgatgtatg 1678441 gcttggcaat gcacaggagc tcatccacaa taatatttgt gagctgagtg aggttatcgg 1678501 ctgccgtgat gacattatgg tttatttaat ctatcaaggc cttgagccgt cccttgcctt 1678561 taaaatcatg gaattcgtgc gtaaaggaaa aggattaacg cctgaatggg aagaagaaat 1678621 gaaaaataac aatgtcccag actggtatat tgattcctgt aaaaagatta aatacatgtt 1678681 cccgaaagcc cacgccgcgg catatgtctt aatggcagtc cgcattgctt actttaaagt 1678741 gcatcatgct cttttgtatt atgcggctta ttttaccgtt cgtgcagatg actttgatat 1678801 tgatacaatg atcaagggct ctacagcaat cagagcggta atggaggata taaacgctaa 1678861 aggacttgat gcttcaccga aggaaaagaa ccttctgact gttttagaat tagcgcttga 1678921 gatgtgtgag agaggctatt cattccaaaa agtcgattta tatcgctcca gcgccacaga 1678981 gtttattatt gacggcaaca gtcttattcc gccgtttaac tctattccag ggttagggac 1679041 gaacgctgct ttgaacattg taaaagctcg cgaagaaggc gaattcctct caaaagaaga 1679101 tttgcaaaag agagggaaag tatcaaaaac gattttagag tacttagatc gccatggctg 1679161 tctggagtca ctgcctgatc aaaaccaatt gtcactgttc taatatggaa agcagaattt 1679221 ctcagaaatt ctgcttctat gcatacataa gcgcaaaaag tgccatcgta atattagagt 1679281 ttctgtcact tgcttaggta tgaaggtaag cgtatatcca tttgcaataa aaatatggtt 1679341 atggtatagt tttattggaa atgctaacga ttaccgaggc aaagagtggg gaaacccgct 1679401 cttttgtatt gaacaggaga attttgtctc gacatgttca tcgtttactt tttagcccct 1679461 gctcttttga agcagggttt ttatgcagag tgacgagacg aatatgagat cgacagcaca 1679521 aggaggaaga acatgagcaa aaaagtgact gacaccgttc aagaaatggc tcagccaatc 1679581 gtagacagcc ttcagctgga actcgttgac attgaatttg tcaaagaggg ccaaagctgg 1679641 ttccttcgcg tgtttattga ttccgatgac ggtgtggata ttgaggaatg tgccaaagta 1679701 agcgaagctt taagcgaaaa gcttgatgag gcagacccaa tcagccaaaa ttactttctt 1679761 gaagtctcat ctccaggagc tgagcgtccg ctaaagaaaa aagccgattt cgaaaaatca 1679821 ctaggaaaaa acgtatacat taagacgtat gagcctattg acggcgtaaa agtgtttgaa 1679881 ggtgaactgg ctgaatttga tggacaaaca gtgacagttg agatcacgat caaaacaaga 1679941 aagaaacgga tcaatattcc gtatgaaaag atagctaatg caagattagc tgttacattc 1680001 taatgaatac aaatgtttta aggggggaga ccgttaaatg agcagtgaat tattagatgc 1680061 tctcacgatt cttgaaaaag aaaaaggcat cagtaaagaa attatcatcg aagcaatcga 1680121 agctgcgtta atttctgctt ataagcggaa ttttaatcaa gcgcaaaatg tacgggtgga 1680181 tctaaaccgt gaaactggct ccatccgtgt atttgcaaga aaagatgtcg ttgacgaagt 1680241 atacgaccag agattagaaa tctcaattga agaggcacag ggcatccatc cggaatatat 1680301 ggtcggcgat gtcgtcgaaa tcgaagttac acctaaggat ttcgggcgca tagctgctca 1680361 aacagcgaag caggtcgtca cacagcgtgt gcgcgaagct gagcgcggtg tgatttattc 1680421 tgaatttatc gaccgtgaag aagacatcat gacagggatc gtccagcgtc tggacaataa 1680481 atttatctac gtgtctttag gcaaaataga agccttgctg ccggttaatg agcaaatgcc 1680541 gaatgaaagc tacaagcccc atgaccgcat taaggtatat atcacaaaag tagaaaaaac 1680601 aacgaagggt ccgcagattt atgtgtcaag aacacatcca ggcctgttaa agcgtttgtt 1680661 tgaaattgaa gtgcctgaaa tttatgatgg aactgtcgag ctaaaatctg ttgccagaga 1680721 agccggcgac cgttcgaaaa tttctgttcg cacagatgat cctgacgttg atcctgtcgg 1680781 ttcatgcgta gggcctaaag gccagcgtgt gcaagcaatc gtcaatgaat taaaaggtga 1680841 aaaaattgac attgtcaact ggtccagtga tcctgtagaa tttgtcgcga atgcgctcag 1680901 cccttccaaa gtgcttgatg tcattgttaa tgaagaagaa aaagcgacaa ctgttattgt 1680961 tcctgattac cagctgtctc tggcaattgg aaaaagagga caaaacgcac gcttagctgc 1681021 taaactgaca ggctggaaga ttgatattaa gagcgaaacg gacgcaagag aacttggaat 1681081 ctatccgaga gaacttgaag aagatgatga gccgctcttt acggagcctg aaactgctga 1681141 atcggatgaa taagaggtga ctttaggtga ataaacacaa aaagatccca ttacgcaaat 1681201 gtgtagtgac tggtgaaatg aagcctaaaa aggaactgat ccgagttgta cggtcgaaag 1681261 aaggcgaaat ctcagtagac ccgaccggaa aaaagaatgg gcggggtgct tatttaacgc 1681321 tggataaaga gtgcatctta gcagcaaaaa agaaaaacac tttgcaaaat caatttcaat 1681381 cacaaatcga tgaccagatt ttcgatgaat tgctggaact ggcggaaaag gtgaaaaaat 1681441 aaaatgtctg gaatggaatg gtttcccttg ctgggtctgg ccaatcgagc tcgtaaggtc 1681501 gtgtcaggcg aagacttggt aataaaagaa atcaggaatg cgcgtgcaaa gcttgtcctg 1681561 cttacagagg atgcatcatc taacacagca aaaaaagtaa ctgacaagtg caattattat 1681621 aaagtccctt ataaaaaagt cgagagtcgc gcggttcttg gacgctctat cggtaaagaa 1681681 gcccgtgtcg ttgtcgccgt cactgaccaa ggttttgcga ataagctgat cagcttgctc 1681741 gattaatatt tttgggggtg aacgaatggc taaaatgaga gtatacgaat atgcaaaagc 1681801 gttaaatgtt tcaagtaagg aaattttgac cgcactgaag aacatggatt tagaagtgaa 1681861 taatcacatg gccatgcttg aagaaaaggc cattaaaaag ctagatgcca aatataaaaa 1681921 aggcggcgca gctgctaaat ctcaaaagcc agcagaaacg aacaaaaaca aacagccaca 1681981 aggggttaat cagcaatcag ctggaaatca accaaataaa attcgagacg gaaagaagaa 1682041 tgacgtgcag aataatcaat ttaacaaaaa caagaagaat aacaacaaca aaaaaaataa 1682101 acgcaacaac aacaataata aaaaccaaca tcagcaaaag cctgtaaagc cgaaaaaaga 1682161 gcttcctgag aaaattacat tctctggcac tttaacagtt ggcgcacttg ctgaagagct 1682221 tggcaaagag ccttcagaac tcattaaaaa gctgatgctt cttggcgtaa tggcaaccat 1682281 taaccaagag cttgataaag acacaatcga actcattgca tcagaatatg gtgttgaaac 1682341 agaagaggtc attgtgcttg aagaaacaga gctggaaaaa tacgaagagc ctgataatga 1682401 agaggatctt gaaattcgtc ctcctgtcgt gacaatcatg ggccacgttg accatgggaa 1682461 aacaacgctt cttgacagca tccgtaaaac aaaggttgtt gaaggggaag caggcggaat 1682521 cactcagcat atcggcgctt atcaaattga agagaacggc aagaaaatca cgttcttgga 1682581 tacaccgggc cacgccgcat ttacaacaat gcgcgcacgc ggtgcagaag taactgatat 1682641 tacgattctt gtcgtagctg ccgatgacgg tgtcatgccg caaacagttg aagcgattaa 1682701 ccatgcaaaa gcagcagagg ttccaatcat cgttgctgtg aataaaatag ataaagaatc 1682761 cgcaaaccct gaccgtgtaa tgcaagaact gacggaatac ggacttgtcc ctgaagcttg 1682821 gggcggagaa accatttttg tgccgctttc cgctttaact ggaaaaggca ttgatgagct 1682881 cgttgaaatg attttgcttg tcagtgaggt agaggaactg aaagcgaatc cgaatcgtca 1682941 ggcaaaagga acggttattg aagctgaact cgataaaggc agagggtcag tcgcgacgtt 1683001 gctcgtacag actggaacac tgcatgtcgg tgatccgatc gtagtcggca atacatttgg 1683061 ccgtgtccgt gcaatggtca acgacattgg ccgccgtgtg aaaactgccg gcccgtcaac 1683121 tccggttgaa attaccggtt tgaatgatgt ccctcaagcg ggagaccaat tccttgtctt 1683181 taaggatgaa aaaacagctc gttctgtcgg tgaagcccgt gcttcgaaac agcttgaaga 1683241 gcagcgcagc gataaagcga agctcagtct tgatgattta tttgagcaaa ttaagcaagg 1683301 tgatgtaaaa gacatcaacc tcatcgtaaa agctgacgtt caaggatctg ctgaagcttt 1683361 aacggctgca cttcaaaaaa ttgaagtaga aggcgttaaa gtgaaaatca tccatacagg 1683421 cgttggtgcg attactgaat cagacattat cttggcatct gcttccaatg caattgttat 1683481 cgggtttaat gtgagaccgg acggaaatgc taagagtacg gctgaagctg aaaatgtaga 1683541 tattcgactt caccgtatca tttacaaagt aatcgacgag attgaagctg ccatgaaagg 1683601 tatgcttgat cctgaatatg aagaaaaagt aattggtcaa gtagaagtac gccaaacatt 1683661 caaagtatct aaaatcggta caattgccgg cggatatgtt actgaaggaa ccattacgcg 1683721 cgacagcggc ctccgtttaa ttcgtgacgg cgtcgtcatc tttgaaggcg aagtagatgt 1683781 tctgaaacgc tttaaagacg atgtgaaaga agtttcacaa ggctatgaat gtggtattac 1683841 aattaagaaa tacaatgaca ttcgtgaagg tgacatcctt gaagcgtttg tcatgcaaga 1683901 aattgaaaga acgtgatcgg atttgcggag tgtgaatgca tcatttatga tgcaggatcg 1683961 ctaaaagaaa agcgtgccgt tctgaagcgg attttaacca gggttcaaaa caagttcaat 1684021 gtttcgattt cggagattgg ctatcaggac acctggcaaa gaaccagctt cggaatcgcc 1684081 gctgtttctt cctctcgcgt tcaaacagaa aaagaactgc agcgcgtcct agcgtttatc 1684141 gattcttttc ctgaaattga acggacgatc actaggacag agtggtttta acttagaggt 1684201 gattgaattg agtatgagag caaaccgtgt cggcgagcaa atgaaaaaag aactcggtga 1684261 tattatcagc cgcaagctga aagacccgag aattggtttt ctgacagtaa cggatgtacg 1684321 tgtatcaggt gatttgcaaa ttgcaaaggt gtatatctcg gttctcggtg acgagaaaaa 1684381 acgggaagaa gcgctgaaag ggctggcaaa agcgaaagga tttatccgat ccgaaatcgg 1684441 cagccgcatc agacttcgaa aaacgcctga aattgaattt gagttcgatg aatcaatcga 1684501 ttacgggaat cggatcgaaa cactgattca cgaattacat tcagagaaac catctgaata 1684561 aaaaaagaga ggataggcgt atatcgtctg tcctctttct tcgtttataa gaaaaaaact 1684621 caaaagaagg agtgaaaggc aaatggttaa cggagttctc cttttacata aacctgttgg 1684681 catgacatcg cacgactgtg tcatgaagat ccgaaagctg ttaaaaacaa aaaaagtagg 1684741 acatacagga acgctcgatc cggaagtatc aggcgtgctt ccgatttgtg taggaagagc 1684801 gacaaaaata gtcgaatact taactgaaaa atctaaaacg tatgatgcag aaataacatt 1684861 gggcttttca accacaacag aggatcaaac cggagaaacg gtggaaacaa agcctgtcaa 1684921 tcacgacatt gataaagcgg atgtagaaaa ggttttaaac agtttaaagg ggaaacaaga 1684981 acaaattccg cccatgtatt ccgctgtaaa agtaaacggc aaaaaattat acgaatacgc 1685041 aagagcaggg attgaagtag aacgtccgaa acgtatgata accattgaag acattgccct 1685101 gacaacagag attaaacatc atggagaaac cgcaagcttc cggtttacag tgacttgctc 1685161 caaagggacc tatgtaagga cgctggcggt catgatcgga gaaaagctcg gatatccggc 1685221 ccatatgtct catttaatcc gtacggcatc cggagatttt tctctcgacg aatgctttac 1685281 ttttgatgaa ctcgaagcac aggcccaatc cggaaccgtg gaagagcata cagttcctat 1685341 tgaacgtgcg ctcaatcatt tgccgaaatg gatcataagt gatacattag ctaagaaagt 1685401 agaaaatggg gctttgcttg agacgcccga gcagttttct gaaatgacaa gtggagaccg 1685461 tattgccgtc tttactgaat ccggaacctg cttggcgatc tatttccctc atcctgcaaa 1685521 aaaagggctg ttaaagccgg caaaagtatt gatgcaaaaa agcgaacaat agaaaaaagg 1685581 tgaccgttct gtgaagacga tacatattac acatcctcat catttaataa aagaggagca 1685641 ggcaaaatca gtgatggcgt taggttattt tgacggcgtt catctcgggc atcaaaaggt 1685701 aatcggcaca gcgaagcaaa tagccgaaga aaaaggtctg acattagctg tgatgacctt 1685761 tcatccccat ccttctcacg tgttgggcag agataaggaa ccaaaggatc tgattacgcc 1685821 tcttgaagac aaaataaacc aaattgaaca attaggcaca gaagttctgt atgtcgttaa 1685881 atttaatgaa gtgtttgctt ctctttctcc taagcagttt atagaccagt atattatcgg 1685941 ccttaatgtg cagcacgcag tggcaggctt tgactttacg tacggcaaat acggcaaggg 1686001 aacaatgaag accatgccgg atgatttaga cggaaaagct gggtgcacaa tggtagaaaa 1686061 attaacggag caggataaaa aaatcagttc ttcgtatatc cgtaccgcgc ttcaaaacgg 1686121 agatgttgaa ttggcgaatg tcttgcttgg acaaccttat tttattaaag gaattgtcat 1686181 tcatggtgat aaaagagggc ggaccatcgg gtttccgaca gcgaatgtcg gtttaaataa 1686241 cagctatatc gttccgccca caggtgtata tgccgtaaaa gcggaagtga acggcgaagt 1686301 ttacaatggc gtttgcaata ttggctataa gccaacgttt tatgaaaagc gccctgaaca 1686361 gccttccatc gaggtcaatc tgtttgattt caatcaagag gtatatggag ccgctataaa 1686421 aatcgaatgg tacaaacgga ttcggagcga gcggaaattc aatggcatca aagaattaac 1686481 tgagcaaatt gagaaagata agcaggaagc catccgttat ttcagcaatt tgcggaaata 1686541 acttgcaacg cacgcaaatt ttattctaaa atatttgcat ataggcacga tttttagtat 1686601 gatagttttc gtagtcttaa aaccattgct tggcaatccg aagtcaccga cggttgctag 1686661 gtaactgggg ctaaatatga tttggaggtg aaacaggatg gcaattactc aagagcgtaa 1686721 aaaccaactc atcaatgagt tcaaaacaca cgaatctgat actggatctc cagaagttca 1686781 gatcgctatc ctaactgact caattaacaa cttgaacgag catttacgta ctcacaagaa 1686841 agaccaccac tcacgtcgcg gtcttcttaa aatggtaggt aagcgtcgta atcttcttac 1686901 gtatctgcgt aataaagacg taactcgtta ccgtgagtta attaacaaac taggcttacg 1686961 tcgataatcg taaaaagcgg gaggattccc gcttttttat cgtattaaag cgaaatttct 1687021 tataacaaat cattgaaatc cttttacata ctactttgac attgatatgt tcaattcatt 1687081 tcgttcataa taggagtaat tgattatttc acacaacgaa gagaggagtt cgtaattgta 1687141 tgggacaaga aaaacatgtc tttaccatag attgggccgg aagaacgctt accgttgaaa 1687201 ccggccagct tgccaaacag gcaaatggtg ctgtgatgat ccgctacggt gatacagcag 1687261 tacttagtac agcaaccgct tcaaaagaac ctaaaccgct tgatttcttc cctcttactg 1687321 taaactatga agaaagatta tatgcggtag ggaaaattcc gggcggattt attaaaagag 1687381 aaggacgtcc aagtgaaaaa gcggttcttg ccagccgttt aattgaccgt ccgatccgtc 1687441 ctttgtttgc cgatggattc cgtaatgaag ttcaagtcat cagcattgtc atgagtgttg 1687501 accaaaactg ctcttcagaa atggctgcca tgttcggttc atctcttgca ctttctgtat 1687561 cggatattcc gtttgaagga ccgattgcag gggttactgt cggacgcatt gatgatcaat 1687621 ttatcattaa cccgacagtc gatcagcttg aaaaaagcga tatcaatctt gtcgttgccg 1687681 gcacgaaaga tgcgattaac atggtagaag cgggagcgga cgaagttcct gaggaaatca 1687741 tgcttgaggc cattatgttc ggccatgaag agattaaacg cctgattgca ttccaagaag 1687801 aaattgttgc agcagtcggc aaagagaaat ctgaaattaa gctctttgaa attgatgaag 1687861 agcttaatga aaaagtaaaa gctttggcag aagaggatct gctgaaagcc atccaagttc 1687921 atgaaaagca tgcccgtgaa gatgccatta acgaagtgaa gaacgcagtt gtggcaaaat 1687981 tcgaggatga agaacatgat gaagacacaa tcaagcaagt gaagcagatt ttatccaagc 1688041 ttgtgaaaaa tgaagttcgc cgcctgatta ctgaagagaa agtaagaccg gacggccgcg 1688101 gtgtcgatca aatccgtccg ctctcttcag aggttggcct cttgccaaga acgcacggtt 1688161 caggtctatt tacaagggga caaactcagg ccctcagcgt atgtacgcta ggtgctctgg 1688221 gagatgtgca aatccttgac ggcttaggtg tcgaagagtc gaaacggttt atgcatcatt 1688281 acaacttccc gcaattcagc gttggggaaa caggaccgat gcgcggaccg ggacgtcgtg 1688341 aaatcggaca cggagcactg ggtgagcgtg cgcttgagcc agttattccg tctgaaaaag 1688401 acttccctta tactgtccgt cttgtttcag aagtgcttga atcaaacggt tctacatctc 1688461 aagcaagcat ttgcgcaagc acacttgcaa tgatggatgc cggtgtaccg attaaagcgc 1688521 cagttgctgg tattgcgatg ggtcttgtca aatcaggcga acattacact gtcttgactg 1688581 acatccaagg catggaagac gcgctcggag atatggactt taaagtagcg ggaactgaaa 1688641 aaggcgtaac ggccctgcaa atggacatta aaattgaagg cctttccaga gagattcttg 1688701 aagaagcgct tcagcaggcg aaaaagggca gaatggaaat cctcaacagc atgcttgcaa 1688761 cattaagcga atcaagaaaa gagctttctc gatatgcgcc taagatctta acaatgacca 1688821 ttaatcctga taaaatccgc gatgtcatcg gaccaagcgg gaaacaaatc aataagatca 1688881 tcgaagaaac cggtgttaaa attgatattg agcaggacgg cacaatcttt atttcctcta 1688941 cagatgaaag cggcaaccaa aaagcgaaaa aaatcatcga agaccttgtg agagaggttg 1689001 aagtcggcca actttaccta ggtaaagtga aacggattga aaaattcggg gctttcgttg 1689061 aaattttcag cggaaaagac ggtttggtgc acatttcaga gcttgcgctt gaacgcgtag 1689121 ggaaagttga agatgttgtg aaaatcggag acgagattct tgtcaaagtc actgaaattg 1689181 ataaacaagg acgagtgaat ttatcccgca aagcggtgct ccgtgaagag aaagaaaaag 1689241 aagaacaaca atcttaaatg aaaacataaa aggagcctgg gagacccggc ttctttattt 1689301 tgaagctttt caaaagcagg cgggttctac cttgtccttc tccttcataa tgtgaggtga 1689361 gggggggaca gaacatgtac aaaaaatttg taccgtttgc cgttttttta tttctttttt 1689421 ttgtctcatt tgagatgatg gaaaatccgc atgcacttga ttatataggg gcaatgaaaa 1689481 aagatacggt gactgtcacg gcgtcaaaag acccgttata tgaagaattg cttcaaaaag 1689541 cgccggagta cgaagttaag ccccagaatg caagaattga taaagtgtgg aaaagcattc 1689601 caggctacaa tggattaaag gtcaatattg aacaatcata taaaaaaatg aaacagcatg 1689661 gtaagtttcg ggaaaaagat ttggtgtaca gtcaagtaaa accaagtgtt catcttgagt 1689721 cacttcagcc tgagcctatt tataaaggaa atcctgacaa accgatggtg gcttttttaa 1689781 tcaatgtggc atggggaaat gagtatttgg aaaaaatgct tcctattctg caaaagcacc 1689841 aggttaaagc tacgttcttt ttagaaggca attgggtgag aaacaatgta cagctcgcta 1689901 agaagattgc aaaagacgga catgaaatcg gaaatcattc atacaatcat ccggatatga 1689961 gcaaactgac tacaggaaga atttccgagc agctcgacaa gactaatgaa caaatagaac 1690021 aaacgatcgg cgttaagcca aagtggttcg ctccgccaag cggaagtttc agaaaagcgg 1690081 ttatcgacat tgcagcagag aaacagatgg gaacagtcat gtggacagtt gatacaatcg 1690141 attggcaaaa gccggctccg tctgtacttc agacgagagt gttaagcaag atacataatg 1690201 gtgccatgat tttaatgcat ccgactgacc ctacggcgga aagtcttgaa gcgctgatta 1690261 cacagataaa agacaaagga tatgcgcttg gaacagtcac tgaactaatg gatgaaacaa 1690321 gactattgaa gtaacagatg aaggcagctt gtctttgaat aggaggaaca aatttgatta 1690381 aacgatatac gtgtcaaaat ggtgtaagaa ttgtgctgga aaataacccg acagtccgtt 1690441 ctgttgcgat cggcgtatgg atcggcacag gttcgagaca tgaaacgccg gagataaacg 1690501 gaatttctca ctttttagag cacatgttct ttaaagggac gagcacaaaa tctgcacgcg 1690561 agatagcaga atcttttgat cgtattggcg gccaggtcaa tgcgtttact tcaaaggaat 1690621 atacctgcta ctatgcaaag gtgcttgacg agcatgcgaa ttacgcgctg gacgtattag 1690681 cagatatgtt ctttcattca acgtttgatg aaaacgagct gaaaaaagag aaaaatgtag 1690741 tatatgaaga aattaaaatg tatgaagatg cgccggacga cattgtacat gatttattga 1690801 gcaaagccac ttacggcaat cattctttag gctacccaat tttaggaacg gaagaaacgc 1690861 ttgcttcctt taacggtgac tctctcagac aatacatgca tgattattat acgccggacc 1690921 gagtggtgat ttcggtagcg ggcaatatat ctgacagttt tatcaaagat gtagaaaaat 1690981 ggttcgggtc atacgaggcg aaaggcaaag cgacaggcct tgagaagcct gagttccaca 1691041 cggaaaaact gacgagaaaa aaagaaacag agcaggctca tttgtgcctt ggatttaaag 1691101 gcttagaggt tggccatgaa cgtatttatg atttaatcgt cctcaacaat gtgctcggag 1691161 gcagcatgag cagccggctg ttccaagatg tgcgtgaaga taaaggactt gcttattctg 1691221 tttacagcta tcacagctca tatgaggaca gcggaatgct aacgatttac ggcggaacgg 1691281 gtgcaaatca gcttcagcag ctgtcggaaa caattcaaga aaccctggcc acattaaaac 1691341 gtgacggcat tacctcgaaa gaactggaaa acagcaaaga gcaaatgaag ggaagcttaa 1691401 tgctgagctt agaaagcaca aacagcaaaa tgagccgaaa cggaaaaaat gaactgctgc 1691461 tcggcaaaca taaaacatta gatgaaatta tcaatgaatt aaacgccgtg aacttagagc 1691521 gtgttaatgg ccttgccaga caattgttta ccgaagacta tgcattagca cttatcagcc 1691581 cttccggcaa tatgccgtct taaaaaggaa agcctgcccc ataatggagc aggcattttt 1691641 taatcccttt catcatacat agtacaaggg ggtgacagac atgcggctca gtgaattatc 1691701 gggaaaggaa attgtagaca tcaaaagagc tgaacggctc ggagtgctcg gccagaccga 1691761 tttggaaatc aatgaacagg atggacagat tacagcactc ctcattccca cagttaagtg 1691821 gtttggtttg agaaagcaag gtcatgacat tcgtgtccca tggcaccata ttcaaaagat 1691881 cggttcagat atgattatat tagatgtacc tgaggaaatg cctcctcgac aagagtaaat 1691941 agcccaattg actgtgaagc gggctctaaa gaaaacatct gaaacatcgg ctgccggagc 1692001 cgatgttttt ttatatggaa aaagcgcatc ttttatattc accggtattt ccttttgatc 1692061 ataagatgaa ggggagctta acaactagag atccagtata tacaaagaag gtgaacgttt 1692121 agaatgttaa ccggattgaa aattgcagtt atcggcggtg acgcaagaca gctcgaaatt 1692181 ataagaaagc tcactgaaca gcaggctgac atctatcttg tcggttttga ccaattggat 1692241 cacggtttta ccggggcagt aaaatgcaat attgatgaaa ttccttttca gcaaatagac 1692301 agcatcattc ttccagtatc cgcgacaaca ggagaaggtg tcgtatcgac tgtattttcg 1692361 aatgaagaag ttgtgttaaa acaggaccat cttgacagaa cgcctgcaca ttgtgtcatt 1692421 ttctcaggaa tttctaacgc ctatttagaa aacattgcag ctcaggcaaa aagaaaactt 1692481 gttaagctgt ttgagcggga tgacattgcg atatacaact ctattccgac agtagaagga 1692541 acgatcatgc tggctattca gcacacggat tatacgatac acggatcaca ggtggccgtt 1692601 ctcggtctgg ggcgcaccgg gatgacgatt gcccgtacat ttgccgcgct cggggcgaat 1692661 gtaaaagtgg gggcaagaag ttcagcgcat ctggcacgta tcactgaaat ggggctcgtt 1692721 ccttttcata ccgatgagct gaaagagcat gtaaaagata tagatatttg cattaatacc 1692781 ataccgagta tgattttaaa tcaaacggta ctttctagca tgacaccaaa aaccttaata 1692841 ttggatctgg cctcacgtcc cgggggaacg gattttaaat atgccgagaa acaagggatt 1692901 aaagcacttc ttgctcccgg gcttccaggg attgtcgctc ctaaaacagc tgggcaaatc 1692961 cttgcaaacg tcttgagcaa gcttttggct gaaatacaag ctgaggaggg gaaataagga 1693021 tgtcgtcatt aaaaggaaaa agaatcgggt ttgggctgac cgggtcgcat tgcacatatg 1693081 aagcggtttt cccgcaaatt gaggagttgg tcaacgaagg agctgaagtc cgtccggttg 1693141 tcacatttaa tgtaaaatct acaaataccc gatttggaga gggcgcagaa tgggttaaaa 1693201 aaattgaaga cctgactgga tatgaggcca ttgattcgat tgtaaaggca gaacctcttg 1693261 ggccgaagct gccccttgac tgcatggtca ttgcgccttt aacaggcaat tcaatgagca 1693321 agctggcaaa tgccatgacg gacagcccgg tgctgatggc ggcaaaagcg acaatccgga 1693381 acaatcggcc tgtcgttctg ggtatctcga caaatgatgc tcttggttta aacggaacaa 1693441 atttaatgag gctcatgtca acaaaaaata tcttttttat tccattcggg caagatgatc 1693501 catttaaaaa accgaattca atggtagcca aaatggatct gcttccgcaa acgattgaaa 1693561 aggcactcat gcaccagcag cttcagccga ttctagttga gaattatcag ggaaatgact 1693621 aaatttacag aaaatctttc ccaaactaaa aaattcggtc atcacccgca tattctatgg 1693681 taaaataaaa cgtaaaatca tagtcaaatc aattcaatga agctgattgg cggaaggagt 1693741 tttacagatg ggaagaggtt tacacgtagc tgttgtcgga gcgacagggg ctgtgggaca 1693801 acaaatgctt aaaacacttg aagacagaaa ctttgaaatg gacacactta cattgctatc 1693861 ttcaaaacgc tctgcgggga caaaagtcac gtttaaaggc caagagctga ctgttcagga 1693921 agcttctcct gagagctttg aaggggtaaa tattgctttg ttcagcgccg gcggaagcgt 1693981 atcacaagca ttggcaccag aagctgtaaa acgcggcgct attgttatag ataatacgag 1694041 tgcgttccgc atggatgaaa atacaccgct tgttgtgcca gaagtgaatg aggcagactt 1694101 gcatgaacac aacggcatta ttgccaatcc aaactgctct acaatccaaa tggttgcggc 1694161 acttgaaccg atccgcaaag catatggctt aaacaaggtc atcgtatcaa cttaccaggc 1694221 agtatcagga gcgggtaatg aagctgtaaa agagctttac agccaaacac aggcgatttt 1694281 aaataaagaa gaaatagagc ctgagatcat gcctgtaaaa ggtgacaaaa aacactatca 1694341 aatcgccttc aacgcgattc cgcaaatcga taaattccaa gataacggct atacgtttga 1694401 ggaaatgaaa atgataaatg aaacgaaaaa aatcatgcac atgcctgacc ttcaagtagc 1694461 ggctacatgt gtgagactgc caatccaaac tgggcactca gagtccgtct acatcgaaat 1694521 agaccgtgat gacgctacag ttgaagatat taaaaatcta ttgaaagaag ctccgggcgt 1694581 gacacttcag gatgatccaa gccagcagct ttatccgatg cctgctgatg ctgtcggcaa 1694641 aaacgatgtg tttgtaggcc gcatccgcaa agacttggac agagcaaacg gttttcattt 1694701 atgggttgtt tctgataacc tattaaaagg cgcggcatgg aactctgttc aaattgcaga 1694761 aagcctgaaa aaactaaacc tcgtataaaa gagagaattt tctaaagacg aatagaagag 1694821 agtaaggcgc tatcagcctg ctctcttctg ttacgtccga ataatttgga gtgaaaacag 1694881 tgaagataat tgttcaaaag ttcggcggaa catcagtaaa agatgataaa ggccgcaaac 1694941 tggctttagg gcatattaaa gaagcaatca gtgaaggata taaggttgtc gttgtcgttt 1695001 cagcgatggg ccgaaaaggg gacccgtatg caacagattc tttgctcggg ctgctttacg 1695061 gcgatcagtc agcgatttct cctagggagc aggatttgct tttatcttgc ggagagacta 1695121 tttcctctgt cgtctttaca agcatgctgc ttgataacgg tgtgaaagca gctgcgctga 1695181 caggggctca ggctggcttt ttaacgaatg atcagcatac taatgcgaaa atcattgaaa 1695241 tgaaaccgga gcgtttattc agtgtgctcg ccaatcatga tgcggtagtc gtcgcaggct 1695301 tccagggcgc aactgaaaag ggtgatacaa caacaatcgg cagagggggc agcgatacgt 1695361 ctgcagccgc actcggagca gctgttgatg cggaatacat cgatattttc accgatgtag 1695421 aaggcgtgat gactgctgac ccaagagtgg tagaaaatgc aaaaccgctt cctgttgtga 1695481 cgtatacgga aatctgcaac ctggcgtatc agggggccaa ggtcatttct ccgcgtgctg 1695541 tggaaatcgc aatgcaggcc aaggttccga tccgcgtccg ttcgacttat tcgaatgata 1695601 aaggcacatt ggtgacatca catcactctt ccaaggtcgg cagtgatgtt tttgaaaggc 1695661 tgattacggg aatcgcccat gtcaaagatg tcacgcagtt caaagtgcct gcgaaaatcg 1695721 gccagtataa cgttcagact gaagtgttca aggctatggc aaacgctgga atcagtgtcg 1695781 atttctttaa cattacacct agtgaaatcg tctatacggt agccggaaat aaaacagaaa 1695841 cagctcagcg tattttaatg gatatgggct atgatccaat ggtgacgaga aactgcgcga 1695901 aggtatcggc ggtcggcgcg ggcattatgg gtgttcccgg tgttacgtcc aaaattgtat 1695961 cggctctttc agaaaaagaa attccgatcc ttcagtcggc tgacagccat acgacgatat 1696021 gggtgctcgt ccatgaagcg gatatggttc ctgctgtaaa cgctttgcat gaagtgtttg 1696081 aactttcgaa gtaaatgtga ttgaatcatg atgaggtgaa taaaatgaat ttcggaaatg 1696141 tgtctacagc gatgattaca ccctttgaca ataaagggaa cgtagacttt caaaaactgt 1696201 ctacactgat tgattacttg ttgaaaaacg gaacggattc tttagtagta gcgggaacaa 1696261 ctggagaatc tccgaccctt tcaactgaag aaaaaattgc gctttttgaa tatacggtaa 1696321 aagaagtaaa cggacgggtg cccgttatcg ctggtactgg gagcaacaac acgaaagatt 1696381 ccattaagct gacaaaaaaa gctgaggaag cgggcgtgga cgctgttatg cttgttaccc 1696441 cgtattacaa taaaccttct caagaaggaa tgtaccagca ttttaaagca attgcggcag 1696501 agacatctct tccggttatg ctctataatg ttcctggccg tacggttgct tctcttgctc 1696561 ctgaaacgac gatccgtttg gcggcagaca ttccgaatgt ggttgcgatt aaagaagcga 1696621 gcggagacct cgaagcgatt acaaaaatta ttgctgaaac acctgaagac ttctatgtct 1696681 attcagggga tgatgctcta acgcttccaa ttctttcagt tggaggtaga ggagttgtgt 1696741 cagtggcgag ccatattgca ggcactgata tgcagcaaat gatcaaaaat tatacgaatg 1696801 ggcaaacagc taatgcggca ctgattcatc agaaactgct gccgattatg aaggaactgt 1696861 ttaaagcgcc taatcctgct ccagtcaaaa cagcgcttca gctgagaggt cttgatgtcg 1696921 gttctgtgcg tctgcctcta gtcccattaa ctgaggatga acgtctgagc ttaagcagca 1696981 cgatcagcga actgtaagaa aatttcatac agtgaaacaa acgcggtcat tctcacattc 1697041 agctgagttt gaccgtttct tttacatatt ggttttccct aaaccttctg ctttatcttg 1697101 ttttctaaat ttactttcag ttataatagg aacaagtgat gatggacggg tatgagacta 1697161 ggaggatata gattttgaaa aagaaaaata cagaaaacgt tagaattatc gcccttggcg 1697221 gtgtcggaga gattgggaag aacctttatg tcattgaaat tgactcagac atatttgtcg 1697281 ttgatgccgg ccttatgcat ccagaaaacg aaatgctcgg tattgatgta gtgattcctg 1697341 acatatcata tttgattgaa cgggctgacc gcgtcaaggc aatcttttta acgcacgggc 1697401 acgatgaaaa tatcggcggc gttttttact tattaaacaa gctgtccgtt ccagtgtacg 1697461 gaacaaaact gacgcttgca ctgttaagag agaaattaaa acaatacgga cataaccgaa 1697521 aaactgattt aagagaaatt cactccaaat ctgtcattac atttgaatca acaaaggtat 1697581 cgttctttag aacgattcac agcattcctg attctgtagg tgtgagcttt aaaacatcac 1697641 ttggatctat tgtatgcacg ggagacttca aatttgacca aacacctgca cttaatcaga 1697701 cgtgcgacat tggcgagatc gccaagatcg gcaatagcgg cgtgctcgct ctgctttctg 1697761 acagtgcaaa tgcggaacgg ccgggttaca ccccttcgga agcggctgtc agcggagaaa 1697821 tttcggatgc gctgtataat tcacagaacc gggtgattat tgctgttttc gcatccaata 1697881 ttaaccggat tcagcaagtc attcatgcag cggctcaaaa tggcagaaag attgccgtag 1697941 ccggaaaaaa tcttcaatct gtcctgcagc tggcgagaaa gttaggatat attgaagcag 1698001 atgatgaatt gtttatttct gtacaggatg tcaaaaaata tccgaagcgc gaagtggcca 1698061 ttattacagc cggaagccaa ggtgaaccat tagctgcttt gacaagaatg gcaaacaaag 1698121 ctcacaaaca gctgaacatt gaagaagggg atacggtggt cattgcgtca actccgattc 1698181 ccgggcagga actcatttac tctaaaacag tagatcttct tgcgagagcc ggtgcacaag 1698241 tcatctttgc ccaaaagcgt gttcatgtat caggccacgg ctcacaagaa gagttaaagc 1698301 tgatgatcaa cctgcttaaa ccaaaatatt tgattcctgt aaacggcgaa tacagaatgc 1698361 aaaaagctca ttcaaaaatc gctgaagaaa ccggcatgaa gcgcagtgac atcttcttaa 1698421 ttgaaaaagg cgacgtcgtt gaattccgcg gccaaaacgt aaaaattggg gataaagttc 1698481 cttacggcaa tattttaatt gatggtttag gtgtcggtga tatcggcaat atcgtattga 1698541 gagaccgccg cttgctttca caggacggaa ttttaatcgt tgtcattaca cttgataaac 1698601 aaaagaaaca tcttgtatca ggaccagaaa ttatcactcg cggctttgtt tatgtaagag 1698661 agtctgaagg tcttatcgta caggctactg agcttgtacg gtccatcgtg acagaagcga 1698721 ctgaaacatc aaatgtcgaa tggtcaacgc tgaagcaggc aatgcgggat gctttgaacc 1698781 aattccttta tgaaaaaacg aaacgtaaac cgatgatcat cccaattatt atggaagtat 1698841 aatgactgac taaagaccgg agctgctccg gtctttattt tttgtccttc aagccgggat 1698901 tgaatgaagt atctttgttc ataatacaaa gagaaactcg gaaaggatga aagcgagatg 1698961 gatcatcgta tggaaaacac agaagaagag cgtcctgaaa aaaatgatgc gaaggacagc 1699021 attatgaata aaatacagca gcttggtgaa acgacgcttc cgcagctgcc ccaagataca 1699081 aatattcatt gtctgaccat tatcggacaa attgaaggcc atgttcagct tcctccgcaa 1699141 aacaaaacaa caaaatatga acatgtcatc ccgcagattg tggcaattga acaaaatccc 1699201 aaaattgaag gcttgctgat catattaaat actgtcggag gagatgttga agctggtctt 1699261 gccatagcgg aaatgcttgc atctttatcg aaaccgaccg tttctatcgt gcttggcggg 1699321 gggcattcaa tcggcgttcc gattgctgta tcctgtgatt acagctatat cgccgaaaca 1699381 gcaacgatga cgattcatcc agttaggctc accgggctgg tcatcggggt gccgcaaacg 1699441 tttgaatacc tggataagat gcaagaaaga gttgttaaat ttgtgacaag ccattccaat 1699501 ataaccgaag agaagtttaa agagctaatg ttttcaaaag gaaacttaac acgcgatatc 1699561 ggaacaaatg tagtcggtaa ggatgcagtt aaatacggat tgatcgatca cgcaggcggt 1699621 gtcggacagg caatcaataa actgaatgag ctcatcgatg aagcaaggaa agaagaagga 1699681 cggatgattc aatgattctt tataccgtga tgcctcagga aattgtgttt gcagaacaga 1699741 accaagagac aagcgcacat gagcaaattg aatataaagg tgtaccgctt ctagtcgaaa 1699801 tgaaagggaa tgaagcggaa gtcattcaaa tcatgagcac caatccaatg cattttctgc 1699861 atccggacat ttcaccggga caaaagctga aattaaacgt ataagaatcc aacccttttt 1699921 taagggcaaa atatgctata ataggggaat cctacagaaa aaacgcagcc tgtaaacggc 1699981 tgctttcttc attatgtatg aacttacatt ttttaacgca gtaaggtgat gagtgtggca 1700041 aagaaaaaac gaaaatcaag aaaaaaacag gcgaaacagc tcaatataaa atacgagctc 1700101 aacggattgc tgtgtatagc catttcaatt atcgcaatct tgcagctggg ggtagtcggg 1700161 caaacgttta tctatttgtt ccgctttttt gctggagagt ggtttatttt atgcttgtta 1700221 ggtttattgg tgttaggagt ctcactgttt tggaagaaaa aaaccccaag ccttttaacg 1700281 agacgaaagg ccgggttgta ctgtattatc gcaagcatat tgctgctttc tcacgtgcag 1700341 ctatttaaaa atttgacgca caaagggtct attgagtctg caagcgtggt gcgcaatacg 1700401 tgggaattgt ttttaatgga catgaatggc agctctgctt cacctgattt aggcggaggg 1700461 atgatcggtg cgctgctgtt tgcggcttca cactttttgt ttgcgtcgac tggttctcag 1700521 atcatggcaa ttgtcatgat tttgatcgga atgattttag taacaggacg ctcgctgcaa 1700581 gaaacgctaa aaaagtggat gagcccgatt ggacgtttta taaaagaaca atggttagca 1700641 tttattgatg acatgaaatc cttcaaatca aatatgcagt catcgaaaaa aacgaaagcg 1700701 ccgagcaaaa aacaaaaacc ggcccgcaaa aaacagcaaa tggaaccgga gcctcctgat 1700761 gaagaggggg attatgaaac agtatcgcct cttattcatt cagagccgat tatctcaagc 1700821 ttttctgatc gtaatgaaga ggaagagtct ccagttatag aaaagcgcgc cgaacctgtg 1700881 tcgaagccgc ttcaggacat ccaaccggag acaggtgatc aggaaactgt ttctgctcct 1700941 cctatgacct ttacagagct cgaaaataag gattacgaga tgccgtcact ggatttgctg 1701001 gcagatccga agcataccgg ccagcaggct gataaaaaga atatttatga aaatgcgaga 1701061 aagcttgaac gcacattcca aagctttggc gtaaaggcga aagtcacaca ggttcatctc 1701121 ggaccggccg taacaaaata tgaagtatat cctgatgtcg gagtgaaggt tagcaaaatt 1701181 gtcaatttaa gcgatgattt agcgcttgcg cttgctgcga aggatatcag gatcgaagcg 1701241 cctataccag gcaaatcagc aatcggaatt gaagttccaa acgcagaagt ggcaatggtt 1701301 tcgctgaaag aagtgctgga gtctaaattg aatgacagac cggatgcgaa gctgttaatt 1701361 ggactcggcc gcaatatttc aggtgaagct gtattggctg agttaaacaa gatgccccac 1701421 cttttggtcg caggcgcaac cggtagcggg aaaagtgtct gtgtcaacgg cattattaca 1701481 agtattttaa tgcgggcgaa accgcatgaa gtgaaaatga tgatgatcga tcctaaaatg 1701541 gtagagctaa atgtctacaa cgggattccg catttgcttg ctcctgttgt aaccgatccg 1701601 aaaaaagcgt cgcaggcttt gaaaaaggtt gtcaatgaaa tggagcggcg gtacgaatta 1701661 ttttctcata cgggtacaag aaatattgaa ggatacaatg attatataaa acgcgccaac 1701721 aatgaagaag gagcgaaaca gccagagctg ccttatattg ttgtcattgt ggacgagcta 1701781 gccgatctca tgatggtcgc ttcatctgat gtggaagatt cgattacgag attgtcccaa 1701841 atggcgcggg ctgccggcat ccatcttatt attgcgacac agcggccatc ggtggatgtt 1701901 atcacagggg tgatcaaagc gaacattccg tcacgaatcg cgttcagcgt atcttcacag 1701961 acggattcaa ggaccattct tgacatgggt ggcgctgaga agcttcttgg ccgcggcgat 1702021 atgctgtttt tacctgtagg ggctaacaaa cctgtccgtg tgcagggagc atttttgtcg 1702081 gatgacgaag tggagaaggt cgtcgaccat gtgattactc agcagaaagc gcaatatcaa 1702141 gaagaaatga ttcctgagga gacgacggaa actcattccg aggttactga tgaactttat 1702201 gatgaagctg ttgaattaat cgtcggcatg cagacggcat ctgtttcaat gctgcaaaga 1702261 agattcagaa ttggctatac gagagcggcg cgcctgattg acgcaatgga ggaacgcggt 1702321 gttgtcggac cgtatgaagg cagcaaacct agggaagtat tattatcaaa agagaaatat 1702381 gatgagctct cttcttaatg aagggagttc cgctttctat agttgtcaat aatgatatta 1702441 tgtaaactga tcacctttct atttattttt tcgacaaaac atgatatagt tgtcccaatt 1702501 gttcaataat ttttatcgaa agtggtttac ggaggggaaa catgtctaca aaagctgata 1702561 atcggcactt gtatttgaaa gtaattgaac gaattaaaga ggatataaaa aatgggatct 1702621 acactgagaa ggaaaagctg ccttctgaat ttgagctttc caaaaagctt ggtgtcagca 1702681 gagcgacgct aagagaagcc ttgcggatac tggaagaaga gcatgtgatt atcagaaggc 1702741 atggtgtagg cacttttgtc cattctaagc cgttatttct ttcgggtatt gaacagctga 1702801 acagtgtaac caagatgata gaacaggcga atatgacccc tggcacgatt tttctatcat 1702861 cacaagtgct tatgccgtct gaagatgata cgaagagatt tcacttggca gaagggcaag 1702921 aactttttta ccttgaacga gtcaggacag ctgacggaca gccgattgtg tattgtatag 1702981 acaaaattcc gatgaatatt ttgccgaatt ctttttctca tcagcaagaa tctatgtttg 1703041 acctgctaga gaaaaattca ggctccgtaa tcagctatgc agtaactgat atagaaccga 1703101 tcggctatca cgataccatt tctccagtgc ttgaatgcga tccggaaaca gctcttttgc 1703161 tgttaaaaca aacccattac gatcagcacg ataaaccggt gctttattct ttaaattatt 1703221 ttagagcgga taaattcaga tttcatgttt tgcgtaaacg attctaaaaa cggacgcctg 1703281 tatgtgtctg tttttttatt tgcactgatt catgtttctt tgtacatact ttcattccgg 1703341 ttaacgcaat atataaggga tgacaagaaa gtgaatgggt gaaaatgttg agagagaaaa 1703401 atggaatgaa aaatattatt gcattgtctt ctgtcccgct tgtgatgaca ctcgggaact 1703461 ccatgctgat tcctgttctt ccgatgatgg agaaaaagct gtctgtgact tcatttcaag 1703521 tatctttaat cattactgta tattcagtag tagcaattat ttgcattccg attgccggat 1703581 atttgtcgga tcgtttcggg agaaaaaaaa tattgcttcc atgcctcctc attgcaggat 1703641 tggggggagc cgtagctgct tttgcctcga cctatatgaa aaatccttat gctatgatct 1703701 tggcggggcg ggttcttcaa ggcattggtt ctgcaggtgc cgctccgatt gtcatgccgt 1703761 ttatcggcga cctgtttaaa ggagacgatg aaaaggtcag cgcgggtctt ggcgatattg 1703821 aaaccgccaa cacgtcaggg aaggtactga gtcccatact tggagcctta ctggcttctt 1703881 ggtattggtt tgtaccgttt tggtttattc cgtttttctg tttgatcagc tttttgctcg 1703941 tattgttttt ggtggccaag cctgaagaag atgaagatgc gcctgctgtt tctgagttta 1704001 ttaagagtgt gaagaaaatt tttaaacagg atggtcgctg gctttatacg gtcttcatta 1704061 tcgggtgtgt cattatgttt ttgttatttg gcgtattatt ttatttatca gatacgctgg 1704121 agaacaagta tgctattgac ggagtagcta aaggcggatt actggcaatc ccacttttgt 1704181 ttttgtcaac cagttctttt atagctggca aaaagatcgg taaagataaa ggccgaatga 1704241 aattttgcgt tgttacagga atgattctgt taaccctttc gtttattgcc ttgtggtgga 1704301 accacagttt ttatttttta tttgtctttt taagctttgg cgggattggg attggaatgg 1704361 ctcttcctgc tttagatgca ttgataaccg aagggattga aagtgaacaa tgcggaacca 1704421 tttcctcctt ttacaatagc atgcgcttta taggagtagc tctcggtcca cctgtttttg 1704481 ctgcattaat gtctaatgca aactggatta ttttcatact ctcggcgttt tgcagcatcg 1704541 tttctttatt tttagtgctc tttactgtag atgctaaaaa aagtgaagaa gaaaaaaact 1704601 tagggacggt ctagccagcc gtcttttttt gcgctttctt gcacagttta caactgtacc 1704661 tatacagcat gcggaggtta ttgtttcctt ataaatccta cagttgctat aattacatga 1704721 aagagtgttt ctgcggatgc tgaaaattgg tcataataca tactaattaa gaaatgaacg 1704781 aaggaggttc catatgtcat atgttaatga actcaaatca aagcacggcg gtttaaccgc 1704841 acacattgta aaaacagaaa aattcaaaac cgtctcgctt atttttaaga tgcttgcgcc 1704901 gctgacaaag gatcaagtca ccaaaagagc gcttctcccg catgtgcttc ttcgcggaac 1704961 gaaaagccat ccgaaaaccg caggattgcg ttcatacttg gatgagctgt acggcacgtc 1705021 agtatcggct gatcttacga aaaaaggaga gcggcatgtc attacgttca ggcttgaaat 1705081 cccgaatgaa aaatatttaa aagaccaaac gccgcttctc gagaaagggc tccagcttct 1705141 cgcagaactc gtcttttcac ctgctttgga gggagacgct tttcagtcac aatatgtggc 1705201 tcaagaaaaa cggacgctta agcaaagaat ccaagccgtc tatgatgata aaatgcgtta 1705261 ttcgaattta aggctgatac aggaaatgtg caaaaatgat ccttacgcgc ttcatgtcaa 1705321 tggtgaaatc gacgatgtcg atgacattac ggcagagcaa ttatacgaaa cataccaaag 1705381 cgctatccaa aaagaccagc ttgatctata tgttgttggc gacgtggaca gtaaccaggt 1705441 acaatcggca attgataagt atttcaaaac agaagagcgc actcttggca tgattgaaaa 1705501 caatcacgct gatgaaaaag ttcagccaaa agaagtaatt gatgaagagg atgtcaagca 1705561 aggaaaactg aatatcggct accgcaccag catcacttat acagatcagg attatcctgc 1705621 tttacaagtg tttaacggat tgttcggcgg attctctcat tctaaacttt tcattaatgt 1705681 tcgggaaaaa gccagtcttg cttactacgc ggcttcgcgt atagaaagtt ttaaaggctt 1705741 gttaatggtg atgtcaggca ttgaagtgaa aaattttgaa caggcggttt cgattattgc 1705801 tgagcaattc caggcaatga aaaatggcga tttcagtgag caggatatag cacagacaaa 1705861 ggccgttatt cgaaatcaag tgctggaaac gattgataca gcatacggtt tatctgagtt 1705921 tttatatcag caggccgctg ctcaagtcga gattcctatc gaagactttc ttgccaatat 1705981 tgagaatgtc acaaaagagg atatcattaa agccggcgaa aagattcagc ttgatacgac 1706041 ttatttctta aaagggacgg agggtgcatc ttgatcaaac caatcgaata tgaacagctt 1706101 caggagacgc tgtatcatga aaaaatgtcc aacggccttg atgtttacgt tttgccgaaa 1706161 aaaggcttca acaagacata tgcggtcttt acaacaaagt acggctcgat agataaccgg 1706221 tttgtccctt taggtaaaaa cgagatggtt cacgtgccgg acgggattgc tcactttctt 1706281 gagcacaagc tgtttgagaa agcggacgga gacgtttttc aagatttcag caaacagggg 1706341 gcttctgcca atgcgtttac gtcatttaca agaacggctt accttttctc aagcacatca 1706401 aatgttgaac gcaatttaga gacgcttatc gatttcgtac aggacccata ttttactgaa 1706461 aaaacggttg aaaaggaaaa agggattatc gggcaggaga ttaatatgta cgacgataac 1706521 cctgattgga ggctttactt cggggtcatt gaaaacatgt acaaagagca tcctgtcaga 1706581 attgacatag cgggaacagt ggaaagcatt tcacatatta caaaagacct tctttatgaa 1706641 tgctatgaaa cgttttatca cccgagtaac atgctccttt tcattgtcgg ccctgtagat 1706701 cctgaagcga ttatttctca ggtaagagaa aaccagggga aaaagccgta tactgatcag 1706761 ccggagatca aacgagaaga agtgaaagag caagaagcgg ttttccgaaa agaaaaagag 1706821 atcaaaatga acgtgcaggg accgaaatgc cttgttgggc tgaaatccaa aaatccgttt 1706881 aaattaggca aagagctctt aaagcatgaa ctttcaatga acttattgct tgaagctctt 1706941 tttggcaaaa gctctgccca gtatgaatca ctttatgaaa aaggatatat tgacgaaacg 1707001 ttcagctttg attttactgc tgaatatggg ttcggttttg cggcgatcgg cggagatacg 1707061 cctgagcctg atcaattggc tgaagacatt tcaagcatgc ttttgcgcgc cggtgaactg 1707121 attactgctg aaaagattga acttgccaga aagaaaaaga tcggcacatt cttaaaagcg 1707181 ctgaattccc ctgaatacat cgccaatcaa tttacccgtt atgcgttctt ggatatgagc 1707241 ctgtttgatg ttgtaacggt actcgagcag attaccctcg aggatgtcca gaacgtaata 1707301 caagaggaaa tcgctgcaga cagactgact gtctgcaagg ttgttcctaa atcataaaca 1707361 aaacatccct ccagtgtgag gggtgttttt ctgcggaaag aaggaaagag gatgaacaaa 1707421 acagcactaa tcaccggagc aagcggcggc attggcaaaa gcatcagcga aacccttgca 1707481 gctagaggat acaatctgct gctgcattac aatacaaatc aaaacgcggc agcggagctt 1707541 gctgaaaaac taagtcagat gtttggcgta aatgcggaga tattacaagc tgacctgtcc 1707601 gcgcaagatg gagcagataa gctgacaagt tcaattgttc agccgattga tgcgattgtt 1707661 ttaaacagcg gacgaagcca ttttgggctg attacggatg tagataacgc aacggtccag 1707721 gaaatggttc agcttcatgt ggcgagtccg tatatgctga cgagaaacct tctgccaggc 1707781 atgattcgga ataaatcggg agcgattgtg gctgtcagct cgatttgggg agagactgga 1707841 gcatcctgtg aagtgttgta cagcatggca aaaggagctc agcattcatt tgtaaaagga 1707901 ttggctaagg agctggcgcc aagcggaatc agagtaaacg ccgtagcgcc gggtgcagtt 1707961 gatacaaata tgatgaatca atttaccccg gctgaaaaag aagagatcgc tgatgagatt 1708021 ccgatcggcc ggctggcccg gccgcaagaa attgcggatg caacagcttt tctcctgtct 1708081 gaaaaagcgt catatatcac cggccaaatt ctgtcggtga atggcggctg gcactgctga 1708141 tccgaaaata ttcggtgtat agtttctttt gcgaaggaca caataatctt gtaacttcac 1708201 atgaaatgga ggaaacaagc atgtcagtat tagaaaactg ggatagctgg aaaaacttcc 1708261 ttggcgaccg tctgaactat gcgcaagata aaggtatgag ccaggatacg attacagatc 1708321 ttgcgacaga aatcggcagc tacttggcta atgaagtgga atctaagaac gagcaggaaa 1708381 aagtgctggc agatctttgg agtgtagcat caaaagatga acagcacgcc attgccaata 1708441 tgatggttaa gcttgttgaa aataacagca ctcactagga agagagggga tttttcctct 1708501 cttttttatg ttttcctcat cacagcaaca ttcttctttc taattagaga aaaatgcttt 1708561 atgataaagg aaggtaaaat tttgccacaa tgaagggggt atatcatttg gcaaagctcg 1708621 aatggtattt tgaatatgaa attcaagtga accgccccgg actgctcggg gatatttcat 1708681 ctcttcttgg gatgctttct atcaacatcg taacgataaa cggcgtcgat ctttccagaa 1708741 ggggaatgct cctcaggtgc cgccatatag atcaaattaa acgattagaa tcaatcttaa 1708801 aaacgatgga aacaattaaa gtaacgaagc ttagagaacc gaggcttcgc gaccgtcttg 1708861 ccgtacgcca cggccgttat attcaacggg atgccgatga caagaaaacg ttccgctttg 1708921 aacgggacga gcttggctta ttagtcgatt ttatggccga attgttcaaa aaagaaggcc 1708981 ataaattaat cggaatcaga ggtatgccgc gtgtcgggaa aacggaatcg attgtagcct 1709041 ctagtgtgtg cgagcaaaag gtggctgttt gtgtcatcaa ccttgctgaa gcagacgata 1709101 agaagccagc tgattgccga tgaatacagc actgaaaatg tctttatcgt tgacggaatt 1709161 gtgtcaacac gaagagggtc agaacgccat ctccagctgg tccgagaaat catgcggctg 1709221 cctgcaacaa aagtggtgga gcatccggac atattcgttc aaaatacaga gtatacacta 1709281 gatgactttg attatattat tgaactgaga aatgaccctg atgaggttat tacatatgaa 1709341 catgccgagg aaccccaaat gtttgatcaa tccgggtttt caagctttga tttttaaaat 1709401 tggaaggtgt ttgttgtgac tgaactagga atccggctca aagaagccag agaggaaaaa 1709461 gcaatgtcat tggatgatct ccaagcggca acaaagattc aaaaaaggta tttaaccgcc 1709521 ttggaggaag gaaactatga cattattccg gggaagtttt atgttcgggc attcatcaag 1709581 caatatgcag aagccgttgg gcttgatgcg gatcagctgt ttgaggagca taaaaaagat 1709641 atccctaata cgtatcatga tgatgtgtct gaaaagatct ccggcatgaa tcttcaaaag 1709701 gaaatgccaa agccagcatc taaggcgctg gagctgctgc caacaatact tgttattctc 1709761 ggcgtgattg tcgtgattgc cattgtgtac gcgatcattc aatttgccaa tcacaaaaac 1709821 agtgatgatc acaatgcggc atcagaaaaa gcaattacgc aaagtgagag caagtacgaa 1709881 atccctaaag attcaacgct gaaagagaat caaaataaca gctctgaaaa agagacagac 1709941 actaaaaaag aaacgaaaga aaacgaagat aagaaaaaag aaaatgacag tgagaagctg 1710001 gagattaaag ctgctggcac tgaaggatcg ttaacgactt atgaagtgtc cggcgctgat 1710061 aaaatcgagc tggaactgaa ggcatcagac agctcctgga ttagagtgcg cgatgaaaac 1710121 agcagctctt taaaagaagg aacgctgaaa aaagacgaaa cctataaaaa agacataact 1710181 gatcagaaac aagttgatat ccgcaccgga tatgcaccta atctgaaaat aaaaatcaac 1710241 ggtaaggttc tttcatatga acttgatccg aaaaaagtga tggcacaaac cataaagatt 1710301 gtaaataaaa aggaagaaaa gtcatcttaa ttaccagatg acttttcttc acgtccgagt 1710361 atgaaattgg aggggcttta tgtttaactt accaaataaa atcacactag ctagaatcgc 1710421 attaatccca atcttcatga ttatcatgct ggcgccgttt gactggggca ggctcgaagt 1710481 tggagacgaa tccatcccgg tcgcacattt ggcgggggcc attctattta ttattgcatc 1710541 tacaacagac tgggtggacg ggtattatgc ccgaaaatta aatctcgtaa caaacttcgg 1710601 gaaatttctt gatccgcttg cggacaaact gctcgtatcc gcagcgttaa ttatccttgt 1710661 tcaatttgat ctcgctccag cttggatggt cattgtgatt atcagcaggg agtttgccgt 1710721 gacaggttta aggcttgtct tagccggaac aggagaagtc gtagctgcta acatgcttgg 1710781 taaaatcaaa acctgggcac agattattgc ggtatctgca ttgcttcttc ataatcttcc 1710841 atttgaactt gtgtcattcc cgtttgcaga cttggcgctg tgggtagccg tcttctttac 1710901 tgtcgtctca ggctgggaat atttctctaa aaattgggaa gcgttaaaaa catctaacta 1710961 agaaagaagg acttcgtcat ggaatttcca aaaaaagcag aaataattgc agtcggttca 1711021 gagttgctgc ttggtcaaat cgccaataca aatgctcaat ttatcagcaa acagctcgct 1711081 gaaatcgggg tcaacgtatt ttatcataca gcggtcggag ataacccgga gcggctgaag 1711141 caggtcatcc gcattgctga agaacgctct gacttcatta ttttttcagg agggcttgga 1711201 cccacaaaag atgatctgac gaaagaaacg attgcaaata cgctgggacg tccgcttgtg 1711261 ttaaatgatg aggcattcca atccattgag gactatttca aacgaacaaa acgcacgatg 1711321 tcacctaata accgaaaaca ggcgcttgtg atcgaaggct ctgacgtgct ggcgaatcac 1711381 tttggaatgg ccccgggaat gctcacagag catgaatcgc gctattatat gcttcttcct 1711441 ggaccgccga gcgaattgcg tccaatgttt gaaaacgagg caaagcctct tctgctgaaa 1711501 aagatgggtt caaatgaaaa aattgtgtca actgttcttc gctttttcgg tatcggtgaa 1711561 tctcagcttg aagccgattt ggaagatatt attgatgcac aaaccaatcc gacaattgcg 1711621 cctttggcgg ctgatggaga ggtgacgctg cgtctgacag ccaaacacgc cgatgaaaag 1711681 gaaacagagc gtctgttaaa agaaacagag gccgttatct tagagcgtgt cggtgaattt 1711741 ttctatggtt acgatgatac ttctcttgta aaagagctat ctatagcatg taaggaaaaa 1711801 ggcataacaa tttctgcggc agaaagcttt accggagggc tgttttctga atggctgacg 1711861 gatcatagcg gtgcctcaaa attatttgcc gggggcgttg tttgctatac aaacgacgtg 1711921 aagcagaatg tgcttggtgt caagaaggaa acattagatc gttttggggc ggtcagcaag 1711981 gagtgcgcat ccgaactggc taagggtgtt caaaaactca ctggcagcga tatcggcatt 1712041 agctttactg gtgtagcagg acctgatgct caagaagggc atgagcctgg gcatgtgttt 1712101 atcggcattt ccgcaaatgg taaagaagag gttcacgagt ttcactttgc gggctccaga 1712161 acggggatca gaaaacgcgg cgctaaatac ggctgccatt taatcttaaa gcttttagag 1712221 caaaaataat attttcagca cattatcctc ctaagaaaac atgatttctc tgatacatta 1712281 tgatattttg ataggaatca cgccaagaaa aaatccgaat atgcgttcgc ttttttcttg 1712341 gcaaatccct tcaaacaggg tatagtatat gtagtggtaa cataaaggag gaaaaaatag 1712401 aatgagtgat cgtcaggcag ccttagatat ggctcttaaa caaatagaaa aacagttcgg 1712461 caaaggttcc attatgaaac tgggagaaaa gacagataca agaatttcta ctgtaccaag 1712521 cggctccctc gctcttgata cagcactggg aattggcgga tatcctcgcg gacggattat 1712581 tgaagtatac ggtcctgaaa gctcaggtaa aacaactgtg gcgcttcatg cgattgctga 1712641 agttcagcag cagggcggac aagccgcgtt tatcgatgcg gagcatgcgt tagatccggt 1712701 atacgcgcaa aagctcggtg ttaacatcga agagctttta ctgtctcagc ctgacacagg 1712761 cgagcaggcg cttgaaattg cggaagcatt ggttcgaagc ggggcagttg acattgtcgt 1712821 tgtcgactct gtagccgctc tcgttccgaa agcggaaatt gaaggcgaca tgggagattc 1712881 gcatgtcggt ttacaagcac gcttaatgtc tcaagcgctt cgtaagcttt caggggccat 1712941 taacaaatcg aagacaatcg cgattttcat taaccaaatt cgtgaaaaag tcggtgttat 1713001 gttcgggaac ccggaaacaa cacctggcgg ccgtgcgttg aaattctatt cttccgtgcg 1713061 tcttgaagtg cgccgtgctg aacagctgaa acaaggcaac gacgtaatgg ggaacaaaac 1713121 gaaaatcaaa gtcgtgaaaa acaaggtggc tccgccgttc cgtacagccg aggttgacat 1713181 tatgtacgga gaaggcattt caaaagaagg cgaaatcatt gatctaggaa ctgaacttga 1713241 tatcgtgcaa aaaagcggtt catggtactc ttatgaagaa gagcgtcttg gccaaggccg 1713301 tgaaaatgca aaacaattcc tgaaagaaaa taaagatatc atgctgatga tccaggagca 1713361 aattcgcgaa cattacggct tggataataa cggagtagtg cagcagcaag ctgaagagac 1713421 acaagaagaa ctcgaatttg aagaataaaa ataaaataag tttcaaatga tacaaaaggc 1713481 tgagtgaaaa actcagcttt tttgtatttt gcaaaaaaat gataaaaata ttgctttttt 1713541 tgacaacttt tttagggctt tattcgtcta acaaaacgtg tgcaaaatgg aatttatttt 1713601 gggaggaaaa aatgaatgac aagcccaacc cgcagaagaa ctgcgaaacg cagacggaga 1713661 aaactaaata aaagaggaaa actgttgttt ggtcttttag cagtgatggt ttgcattacg 1713721 atttggaatg ctcttcatcg aaatagtgaa gaaaacgaac catctcaaga aactgcagcg 1713781 gtttcaaata ccgatcagaa aaaagaggtc aaaaagaaaa ctgccaaaaa atcagaggaa 1713841 caaatcaaaa cagtggatcg aaaccaaaaa atcagcaatt atttaaaaga gatcggtttc 1713901 agcggaacag ccatgattgt cagaaatgga gaaatcgtaa caaataaagg ttttggctat 1713961 gctgaccgta aacactacat tcaaaataat ccattgacat ctttttatgt cggttcatca 1714021 caaaaagcgc tgattgcaac tgctattttg cagcttgagg aaaaggggaa acttcagaca 1714081 agtgatccgg taagcacgta tttacctcat tttcccaacg gacaaacgat tactttgaag 1714141 aatctgctta cacatacatc ggggataaac ggacatattg aaggaaacgg cgccattact 1714201 ccggacgatt taataaaaga tatagaactt cagggaatca aacgtcagcc gggcgtatgg 1714261 gactacaagg attccaacta ttctgttctt gcttatatta ttgctgaagt aagcggtgag 1714321 ccctatgaac agtacataaa gaatcatatt tttaaacctg cgggaatgac gcatgcaggc 1714381 ttttacaaaa catatgaaaa agaaccttat cctgccgtcg ggtataagat ggagggcagc 1714441 aaaacagtta caccgtatat acctgattta tcccagctgt atggagcggg tgatatttat 1714501 atgagcgcta tagatatgta caaatttgac caagcgctga tagacggaaa actgtattcg 1714561 caaaaaagct atgaaaagat gtttacgcca gggagcagct ccacatacgg catgggattt 1714621 tatgttgctc ccggaagcta ttcaaaccat ggtgttatgc cgggcttcaa tatcttgaac 1714681 agctttagca aatctgggca aaccattgtt attttgttct caaacattca aaataatgct 1714741 aaattgggcc aagtgaacaa taaaatatac cagcttctaa atcaagaatg attggcgatc 1714801 ttcttttgga tgaattgcat tcggcacgtg aaaagaagac tggcctgcaa acgttaagat 1714861 ggcaagcttg acaagtattt ccgacacatt tacaatgaag ttgtaacatt tgttttttta 1714921 acatgattgt taaaccattt aaacttgaca agggcgatga acacactcat tccctgtgaa 1714981 ggttctgtat gttgagaaaa ctagacaatg tacatgccga cactttttaa gcaacaacca 1715041 agttcatagc aagaggaggt gaaagtatga ccccaattat gatggttctc atctccattt 1715101 tgctgattct actcggttta gttgttggct actttgttcg taaaaccatt gccgaagcga 1715161 aaattgcggg cgcacgcggt gcagccgagc aaattcttga agatgcgaag cgtgatgctg 1715221 aagcactgaa aaaagaagct ctgcttgaag caaaggatga aatccacaaa cttcgaatag 1715281 atgctgaaca ggaagttcgt gaaagacgaa atgagcttca aaaacaagaa aaccgtttac 1715341 tccaaaagga ggaaaacctt gatcgcaaac atgagggaat tgataaacgg gaagcgatgt 1715401 tggagaagaa agatcattct ctgaatgaac gacaacaaca tattgaagag atggaaagca 1715461 aagtggatga gatgattcgt atgcagcagt ctgagttgga acgaatttcg agtctgactc 1715521 gtgacgaagc gaaacaaatc attcttgagc gggttgaaaa cgagctttca catgacatcg 1715581 ccatcatgac aaaagaaact gaaaaccgtg cgaaagaaga ggcggataag aaagcgaaaa 1715641 acattctttc actcgcctta cagcgctgcg cagcggacca cgttgccgaa acaacggtat 1715701 cagttgtcaa tcttccaaat gatgagatga aaggacgtat catcggacgg gaagggcgta 1715761 acattcgtac gcttgaaacg ctgacaggaa ttgacctgat tattgatgat acgcctgaag 1715821 ctgtcattct ttccggattt gatccgatca gacgtgagac agccagaatt gctcttgata 1715881 aactcgttca ggatggccgt attcatccgg cacggattga agaaatggtt gaaaaatctc 1715941 gccgcgaggt cgatgactat attcgtgaga tgggtgagca aacgacattt gaggttggcg 1716001 ttcatggcct ccacccagat ctcatcaaga tcctcggccg cttaaagttc cgtacaagct 1716061 acggtcaaaa tgtgcttaag cattccatgg aagtcgcatt cttggccggt ctaatggcat 1716121 cggagcttgg tgaagacgca aagcttgcta aacgtgcggg tcttcttcac gacatcggga 1716181 aagcaattga ccatgaagta gaaggaagcc acgttgagat cggggtagag cttgcgacca 1716241 aatataaaga gcacccagtc gtgattaaca gtattgcatc acaccacggg gacgaggagc 1716301 cgacttccat tattgctgta ctggtagctg cagcagatgc gctttccgct gcaagacctg 1716361 gcgcaagaag tgagacgctc gagaattata ttcgaagact tgaaaaactt gaagaaattt 1716421 ctgagtccta cgaaggtgtt gaaaaatcat ttgccattca ggctggacgc gaagtgcgaa 1716481 ttatggtgaa gccggattca attaatgatc ttgaggctca tcgactggcg cgagatatcc 1716541 gcaagcgaat tgaggacgag ctcgattatc caggtcatat taaggtgaca gtaatcagag 1716601 agactcgagc cgtagagtat gcaaaataaa gtgatgcgct aagcatcact ttattttttt 1716661 gacggcaagg aattttcaag aagaaaggat ttacaaaatg agaattttat ttatcggaga 1716721 tgttgtcggt tcaccgggcc gtgacatggt caaagaatat gtaccaaagc taaaaacaaa 1716781 atataagcct cactttacca ttattaatgg tgaaaacgcc gcacatggaa aaggcctgac 1716841 ggaaaaaatt tatcacagct taatccagtc cggcgcagat gcaatcacaa tggggaacca 1716901 cacatgggac aaaaaagaaa tatttgattt tatagatgac gttccgaact tggttcgccc 1716961 ggcaaacttt cctgaaggaa caccggggaa agggatcaca tatgtgaaag caaacggcaa 1717021 agaactagca gtcattaatt tgcagggacg tacgtttttg ccgccgcttg atgacccgtt 1717081 tttaaaagcg gatgaattga tcgcagaagc tgcgaaaaga acaccgtaca tttttattga 1717141 ctttcatgcc gaagcgacaa gtgaaaagct cgcacttggc tggtacacgg atggacgggc 1717201 atcggctgta gtaggaactc atacacacgt gcaaacagcg gataaccgca ttttgccgaa 1717261 gggaacggca tatattactg atgtgggaat gactggcccg tatgacggta tactggggat 1717321 ggacagagag acgattatta agcgattcaa aacgaacctt ccagtccggt ttactgtcgc 1717381 tgaaggaaaa acaacgctca gcggagttgt cattgacatt gacgatcaaa cgaaaaaagc 1717441 cgtgaaaatt gagcgtattt taatcaacga tgatcacatg ttctttgaat agttgaacat 1717501 atggttattt tataaaaata ttaaaaagaa aagcaggaat atagcaactc cttagtgaat 1717561 atagtaaaaa tggaaggtag cccgctattt ttgaaaagca ttgtggggat ggctttttgg 1717621 atagcaacat ctaataatga ttgttctaat gaacactcac ttatccattg taaaactaag 1717681 ggggagcaga aatggaaatc ttaaaagttt cagcaaaatc gagtccaaat tcagtggcag 1717741 gtgcgcttgc aggcgtgttg agagagcgag gagccgccga gattcaagcg atcggagcgg 1717801 gtgcattaaa ccaggctgta aaagctgtgg cgattgccag gggatttgtg gcgccaagcg 1717861 gcgttgattt gatttgtatt ccggctttta cagatattca aatcgatggg gaagaaagaa 1717921 cagcgattaa attaatcgtg gagcctcgct aaaaacaaat aaagcattct caacctgttt 1717981 gcgtaatgca aacaggttgt ttttcattta ttgtgatatt ttctcccgat agtattttta 1718041 gcacataaat gagcgaatat acaaaatcag aaatgagcta aaacgtttca aaaaaaattt 1718101 ccgcccattt ttcaagacag atacttttgt ccttctggaa aagacagttc tgtttacgct 1718161 tattccatat catggtacaa tccgaatata acaagaattt ttcaaggagg attgtacatg 1718221 cagagtggaa agatgaaagc tctaatgaaa aaggacgggg cgttcggtgc tgtgctgact 1718281 gaagttccca ttcctgagat tgataaacat gaagtcctca taaaagtgaa agccgcttcc 1718341 atatgcggca cggatgtcca catttataat tgggatcaat gggcacgtca gagaatcaaa 1718401 acaccctatg ttttcggcca tgagttcagc ggcatcgtag agggcgtggg agagaatgtc 1718461 agcagtgtaa aagtgggaga gtatgtgtct gcggaaacac acattgtctg tggtgaatgt 1718521 gtcccttgcc taacaggaaa atctcatgtg tgtaccaata ctgctataat cggagtggac 1718581 acggcaggct gttttgcgga gtatgtaaaa gttccagctg ataacatttg gagaaatccc 1718641 gctgatatgg acccgtcgat tgcttccatt caagagcctt taggaaatgc agttcatacc 1718701 gtactcgaga gccagcctgc aggaggaacg actgcagtca ttggatgcgg accgattggt 1718761 cttatggctg ttgcggttgc aaaagcagca ggagcttctc aggtgatagc gattgataag 1718821 aatgaataca ggctgaggct tgcaaaacaa atgggagcga cttgtactgt ttctattgaa 1718881 aaagaagacc cgctcaaaat tgtaagcgct ttaacgagtg gagaaggagc agatcttgtt 1718941 tgtgagatgt cgggccatcc ctcagcgatt gcccaaggtc ttgcgatggc tgcgaatggc 1719001 ggaagatttc atattctcag cttgccggaa catccggtga caattgattt gacgaataaa 1719061 gtggtattta aagggcttac catccaagga atcacaggaa gaaaaatgtt ttcaacatgg 1719121 cgccaggtgt ctcagttgat cagttcaaac atgatcgatc ttgcacctgt tattacccat 1719181 cagtttccat tagaggagtt tgaaaaaggt ttcgaactga tgagaagcgg gcagtgcgga 1719241 aaagtaattt taattccata aagggggata aacatgacga aggaatttga gtttttaaaa 1719301 gcagagctta atagtatgaa agaaaaccat acatggcaag acataaaaca gcttgaatct 1719361 atgcagggcc catctgtcac agtgaatcac caaaaagtca ttcagctatc ttctaataat 1719421 tacctcggat tcacttcaca tcctagactc atcaacgccg cacaggaggc cgttcagcag 1719481 tatggagccg gcaccggatc agtgagaacg attgcgggta catttacaat gcatcaagag 1719541 cttgagaaaa agctggcagc ctttaaaaaa acggaggcgg cacttgtatt ccaatcaggc 1719601 ttcacaacaa accaaggcgt actttcaagt attctatcaa aagaggacat tgtcatctca 1719661 gatgaattga accatgcctc tattattgac ggaattcgac tgacaaaggc ggataaaaag 1719721 gtgtatcagc acgtcaatat gagtgattta gagcgggtgc tgagaaagtc aatgaattat 1719781 cggatgcgtc tgattgtgac agacggcgta ttttccatgg atggcaacat agctcctctg 1719841 cctgatattg tagagctcgc tgagaaatat gacgcatttg tgatggtgga tgacgcccat 1719901 gcatccggag tacttggcga aaacggcagg ggaacggtga atcacttcgg tcttgacggc 1719961 agagtgcata ttcaggtcgg aacattaagc aaggcaatcg gagtgctcgg cggctacgct 1720021 gcaggttcaa aggtgctgat cgattatttg cgccataaag gccgtccatt tttattcagc 1720081 acatctcatc cgccggcagt cactgcagct tgtatggaag cgattgatgt cttgcttgaa 1720141 gagccggagc atatggagcg cttgtgggag aatactgcct attttaaagc aatgcttgtg 1720201 aaaatgggtc tgactctcac gaagagtgaa acgccgattc ttcctatttt aataggtgat 1720261 gaaggtgtgg caaagcaatt ttcagatcag ctcctttctc gcggtgtttt tgcccaaagt 1720321 atcgttttcc cgactgtagc aaagggaaaa gccagaattc gcacgattat aacagcagag 1720381 cacaccaaag atgaactgga tcaggcgctt gatgtcatcg aaaagacggc aaaggagctc 1720441 cagctattgt aacaagagga agagtttact cttcctcttt tgattcctta ttgattatta 1720501 ttctcaatga gtgtacaatg ataggttgcc agttgtgcag agcttcaata acctttatac 1720561 tgaagggtgg aagtttggtt tgaaaggaga aaatatgaca tgaatgaaaa acaaaaatta 1720621 gagagcggac aagttcatcc atcggacaaa aaatccgaga aggattacag caagtacttt 1720681 gaagctgttt acattccgcc ttctttaaaa gacgcgaaaa aacgaggcaa ggaagccgtt 1720741 acttatcata atgactttaa aatttctgaa caatttaaag gattgggaga cggaagaaag 1720801 ttctatatcc gtacgtacgg ctgccaaatg aatgaacacg atacagaggt tatggcaggg 1720861 atctttatgg cgctcggtta cgaagcgaca aactctgttg acgatgccaa tgtcattttg 1720921 ttaaatacat gtgcaatccg tgaaaatgct gaaaacaagg tgtttggtga gctcgggcac 1720981 ttaaaagcac tgaaaaaaaa caatcccgat ctgattttag gcgtgtgcgg ctgtatgtcc 1721041 caagaggaat cagtcgtgaa ccgtattttg aaaaaacatc cgtttgtcga tatgattttc 1721101 ggaacgcata acattcatcg cctgccggag cttttgtcag aagcatacct ttcaaaagaa 1721161 atggttgtag aagtttggtc taaggaaggg gacgttattg aaaaccttcc aaaagtccga 1721221 aatggaaaaa ttaagggctg ggtcaatatc atgtacggct gtgacaaatt ctgtacgtat 1721281 tgcattgtgc cttacacacg cggaaaagaa agaagccgcc gccctgagga tatcattcag 1721341 gaagtgagaa ggctcgcaag tgaaggctat aaggaaatta ctctgttagg ccaaaacgta 1721401 aacgcgtatg gaaaagactt tgaagatatg acgtacggac ttggtgattt gatggatgaa 1721461 ctgagaaaaa tcgatatccc gagaatccgt tttacaacga gtcatccgcg cgactttgac 1721521 gaccgcctca ttgaagtgct ggcaaaaggc ggaaatctgc ttgatcacat tcatcttccg 1721581 gttcaatcag gaagctcaga agttctcaag ctgatggccc gcaaatatga cagagagcgt 1721641 tacatggagc tggtgcgaaa aattaaagaa gcaatgccaa acgcttcttt gacaacggac 1721701 attatcgtcg gatttccaaa tgaaacggac gaacagtttg aagaaacgct ttctctatac 1721761 cgtgaagtgg agtttgacag cgcctatacg ttcatttact ctccgcgtga aggcactccg 1721821 gctgctaaga tgaaagataa tgtaccgatg cgtgtgaaaa aagaacgcct gcagcgtcta 1721881 aacgcactgg tgaatgaaat ttctgctaaa aaaatgaagg aatacgaagg caaggttgtc 1721941 gaagtattag ttgagggtga aagcaaaaat aaccctgata ttcttgctgg ctatactgaa 1722001 aaaagcaagc ttgtcaattt caaagggccg aaggaagcca tcggcaaaat cgtccgcgtg 1722061 aaaatccagc aagcgaaaac atggtcgctt gacggagaaa tggtaggaga agcaatcgag 1722121 gtgaaatgag atgacgctct actcaaaaaa agacattgtg cagcaggctc gaaaccttgc 1722181 aaaaatgatt tctgaaacag aagaggttga ttttttcaaa cgggctgaag cgcaaatcaa 1722241 tgagaatgac aaagtgtcca caatcgttaa tcagattaaa gccctgcaaa agcaggctgt 1722301 caatctgaag cattatgaaa agcatgaagc gctcaaacaa gtagaagcaa aaattgacgc 1722361 gctgcaagaa gagcttgaag agattcctgt tatccaggaa ttcagagact cgcaaatgga 1722421 agtaaatgac ctactgcagc tcgttgcaca caccatttcc aaccaagtca caaatgaaat 1722481 catcacatca accggaggcg acctgctgaa aggggaaacc ggttcaaagg tgaagcattc 1722541 aaataacagc tgttctctct aaacacggtg cctttacagg cccgtgtttt tttatcattt 1722601 gtgcggttaa aaatgaacta aataatctat gtaccaaatg ttcaattggt ttttctgtgc 1722661 tcagccgcgt ataaacttta tcgcacttat aagtaaagtt tctaggcacc cctgcataca 1722721 atggaacaga aactttgtat ttttatattt tatttataaa aatgcacact agacaaatgc 1722781 ccagcataag ataacacgaa gaagaacaag gaggcatgcc ggaatgtctg aatacaggga 1722841 aattattacg aaggcagtag tagcgaaagg ccgaaaattc acccaatgca ccaacaccat 1722901 ctcgcctgag aaaaaaccga gcagcatttt gggtggttgg attattaacc acaagtatga 1722961 cgctgaaaaa attggaaaaa cggtagaaat tgaagggtat tatgatataa acgtatggta 1723021 ctcttacgcg gacaacacaa agacagaggt tgtcacagaa cgggtaaaat atgtagatgt 1723081 cattaaactc agatacagag acaataatta cttagatgat gagcatgaag tgattgccaa 1723141 agtgcttcag cagccaaact gccttgaagt gaccatttcg ccgaatggaa ataaaatcgt 1723201 tgtgcaggca gaaagagaat ttttggcgga agtggtaggg gaaacaaagg tagttgttga 1723261 ggtcaatcct gactgggaag aggatgacga ggaagattgg gaagatgagc ttgatgaaga 1723321 gcttgaagac atcaacccgg agtttttagt gggagatcct gaagaataaa aaagggacta 1723381 ggggagacag tacccccaag tctctttttt atattgatat atcattcttt tatcactttt 1723441 tgtttatgtt ataatgaagg ttggaaaata gaaacgttga tacatagtga gggattaaac 1723501 aatggccggt tatacgccta tgatacagca atatttaaaa ataaaggcag agcaccagga 1723561 tgccttttta ttttttcgcc tgggtgattt ttatgaaatg ttttttgagg acgccaaaaa 1723621 agcgtcacaa gagctggaaa ttacgttaac gagcagagac ggcggtgcgg ctgaaaaaat 1723681 accgatgtgc ggtgtgccgt atcattctgc ttccgcgtat atcgaacagc ttattaaaaa 1723741 aggatacaaa gtggcgatct gtgaacagac ggaagatccg aaagccgcaa agggcgttgt 1723801 gaaaagagaa gtagttcagc tgattacgcc cggaactgta atggacggca aaggcatcca 1723861 tgagtcggaa aataatttta tcgcatctgt ttcagcctgc tcgaacggat acggacttgc 1723921 tctgtctgat ttaacaacgg gagaaaattt ggctgttttg attgaacggc ttgaagacgt 1723981 catatcagaa atttattcag tcggcgcacg ggaaatcgtg gtttcaggaa gcttggatgc 1724041 cgatacagtg gcacagctga gagagcggtg cggtgcaacg atttcaattg aagacggaga 1724101 aacagacgaa cacgtaacga tcattgagca cttaaataat gaagatataa caaaaacatt 1724161 tctgcgctta tatacgtatt tgaaaagaac ccaaaagcgc agccttgatc atcttcagcc 1724221 cgtgcaggtg tatgagcttg aggaagcgat gaaaattgac ttgtactcaa agcgtaatct 1724281 ggagctgacc gaaacgattc gttcgaaaaa taaaaaaggc tcccttttgt ggctgctgga 1724341 tgaaacaaaa acggcaatgg gaggccggct acttaaacag tggattgacc ggccgcttat 1724401 cagagtcaat caaatcgaag agcgccaaga aatggtggaa acattaatgt cccatttctt 1724461 tgaacgggaa gatctgcgtg aacgtttaaa agaagtatat gacttagaac gccttgccgg 1724521 ccgcgttgca ttcggaaatg tcaatgcccg ggatttgatt cagctgaagg aatcgttaaa 1724581 gcaagtgcct ggcatcaaac agctggttgc ttcactggct catgacaagg ccaaggaacg 1724641 tgcaaagcgc attgaccctt gcggggatgt acttgaactg ctggaagaag cgctgtacga 1724701 aaaccctcct ttatcggtaa aagaagggaa cctgattaaa gatggttata atcaaaagct 1724761 tgatgaatat cgtgatgcaa gcagaaacgg aaaagactgg attgcccgcc tggaacagca 1724821 ggagcgggaa tacacaggca ttcgctcttt aaaggtcggc tttaataaag ttttcggtta 1724881 ttacattgaa gtgacaaaag caaacttgca tttgcttgag gaagggcgtt atgagcggaa 1724941 gcagacgtta accaatgcag agcgctacat tacacctgaa ttaaaagaaa aagaagcgct 1725001 cattttagag gcggaaaata acatctgtga gctggagtac gagctgttta ccgagctgcg 1725061 cgagaaagtg aagcagtata ttccgcggct gcagcagctt gcaaaacaga tgagcgagct 1725121 ggacgcactg caatgctttg cgacaatcag tgaaaatcgc cactacacga aaccagagtt 1725181 ctctaaagat gaagtcgaag tgattgaagg cagacacccg gttgttgaaa aagtcatgga 1725241 cagccaggaa tatgtcccga acaactgtat gatgggcgat aacagacaaa tgcttctcat 1725301 tacaggtcca aacatgtcag ggaaaagcac gtatatgaga caaatcgcgc tcatttccat 1725361 tatggcgcaa atcggctgct ttgtacccgc gaaaaaagcg gtgctcccga ttttcgatca 1725421 aatttttacg cgaatcggcg ctgcagatga tttgatttcc ggacaaagta catttatggt 1725481 agaaatgctt gaagcgaaaa atgcgattgt caatgcgacg aaaaacagcc tcattctgtt 1725541 tgatgaaatc gggcggggaa cgtccactta tgacggcatg gcgctggcac aggcgattat 1725601 tgaatatgtt cacgatcata tcggcgccaa gacgctgttc agcacacact atcacgagct 1725661 gaccgttctt gaggacaagc tgccccagct gaaaaacgtt catgttcgcg ctgaagaata 1725721 taacggaacg gttgtctttc ttcatcaaat taaagaaggt gcggctgata aaagctatgg 1725781 tatccatgta gctcagcttg ccgaactgcc gggagatctg attgcgcgcg ctcaagatat 1725841 tttaaaagag cttgagcatt caggaaacaa accggaagtg ccggtgcaga aacctcaggt 1725901 gaaagaagag ccggcacagc tgtccttttt tgacgaagcg gaaaagccgg ctgaaacacc 1725961 aaagctttca aaaaaagaaa agcaagtgat cgatgctttc aaatcactta atatactgga 1726021 tatgacaccg cttgaagcga tgaatgaaat gtacaagctg caaaagaaat tacattaaaa 1726081 cggggtgatg aatgtggcaa aagtcatcca actgtcagat gagctttcaa ataaaatagc 1726141 ggcgggcgag gttgtggaac ggcccgcctc agtcgtcaaa gaattggtgg aaaatgcgat 1726201 cgacgctgac agcacagtca ttgaaatcga tattgaggaa gcaggccttg catccattcg 1726261 ggtcttggat aacggcgaag gaatggagaa tgaagattgc aagcgagctt tccggcgcca 1726321 cgcaacgagt aaaataaaag atgaaaatga tttattcagg gtgagaacgc tcggtttcag 1726381 gggagaagcc ctgccgagta tcgcgtcagt ctctcatctg gagattacaa caagcactgg 1726441 tgaaggagct gggacgaagc tcgtcctcca aggaggaaac atcatttccg aatcgcgttc 1726501 ctcaagcagg aagggaactg aaattgtcgt ttccaacctg ttttttaaca caccggcccg 1726561 tttgaaatat atgaaaaccg ttcatacaga gcttggaaac attacagatg tggttaaccg 1726621 tattgctctg gcgcatccag aggtatcgat ccgcctgcgc catcatggga aaaacctgct 1726681 tcaaacgaac ggaaacggag atgtgcgcca tgtactggca gcgatttacg gcacggctgt 1726741 cgccaaaaaa atgcttccgc tgcatgtgag ctccttggat tttgaagtaa agggatatat 1726801 cgccctccca gagattacac gggcgtcgag aaactatatg tcgtctgtgg tcaatggccg 1726861 ttacattaaa aatttcccgc tcgtcaaagc ggttcatgaa ggctatcata cgcttctgcc 1726921 gatcggacgc catccgatta cttttataga aattacgatg gacccgattt tagtcgatgt 1726981 caacgtgcat ccatcgaagc ttgaggtccg gctcagcaag gaaacagagc ttcatgactt 1727041 aatacgtgac ggaattaaag atgtgtttaa acagcagcag ctgattccta gtgcccaggt 1727101 cccgaaaaaa tcagcacctg ccatcaaaaa tgagcagcag tttataacct ttgatgaaaa 1727161 gcctccggaa aaaaaagttc cggaaaaatc gactgcgcca tcttattcac cgatgaagct 1727221 cagctcagtc gtaaaagagc cggttgatgc ggaggaaaaa ttgccccctc tccaatttga 1727281 tgctcctcct atcgttgatc aggaacaaac ccttgaggtg tccgatgttt cagcagaaca 1727341 gcctgaaaca tttgagcagg aatgccatga ggaacagccg cagccagcgt ctgatcgggt 1727401 tccaattatg tacccgattg gccagatgca cgggacttat atattggcac aaaacgaaaa 1727461 cggcctatat attatcgacc agcacgccgc ccaagaacgt attaaatatg agtacttccg 1727521 tgaaaaggtg ggggaggttg agcctgaggt gcaggagatg attgtaccgc tgacgttcca 1727581 ctactccaca aatgaggctt tgattattga acagcacaaa caagagctcg aaagcgtcgg 1727641 tgtcttttta gagtcattcg gctctaacag ttacatcgtc cgctgccacc cagcctggtt 1727701 tccaaaggga gaagaagcag agcttataga agaaatcatt cagcaggtgc tcgactccaa 1727761 aaatatagat attaaaaaac ttcgcgagga agcggcgatt atgatgagct gcaaaggctc 1727821 catcaaagca aatcgccacc tcagaaacga cgaaatcaaa gcgcttctgg acgacctccg 1727881 aagcacatca gacccattta catgcccgca cggccgcccg atcatcattc accactcgac 1727941 atatgagatg gaaaagatgt tcaaacgcgt gatgtagcgg gggtggtagg cattgatcca 1728001 ttctctgaat ggatcaatgc tttttttgta ctccttcgag tgtcagatta taagaaacgg 1728061 ttgtaaacgt gtgagcagtg ttaacgcatt atacttcatg gttcctccgt ataacaaaat 1728121 ttccatttac aggcaattgg gattaatgta tattttgggt gagggggtgg aaacatatgg 1728181 catgtggtcc gaagatcatt atctttttgg atgaacttga tgatccaaat gtgagaatca 1728241 ttttagaatg cagaatttaa attacaacat tgtgttttgc tccctgttcg tgtgaacagg 1728301 gagatttttt cgtttatata actggtgatg tccaaatata gggtgttatg aattttccat 1728361 atctgccatc ggctttaagc tgcttctcta ttaggctggt tatcaaaagc aagttcaatg 1728421 atagccatga aagctgatat cacaacaagc aagacatctg gaatataaat agactgcata 1728481 aagtaatctg caaaacagat cgttataaga ttgctgataa aatacagtat aaaagcaaaa 1728541 agtgcagtct ttttcaatga aagtgatttt gccaaaatga tagagataat ctttgtgagt 1728601 gggtctatga ttaaacctac agcaaagcag gctaaaataa ataaagctaa tgtttgattg 1728661 gaagcgtatg tgatgccaag tatggagaat aagcctttca tcccgaagaa aaagccgccg 1728721 aagatgactg caagcgcgat ggccgcgata aaagtaatag atacaattcc gattaatttt 1728781 gatctcaggt taaaatcttt agagtgctcg ttctgttctt tttggttcat gtatgacact 1728841 cccttcacct gcttactcat acaaacagca cccttgaatc agcccaaaat atctataagt 1728901 ctgttttctg acgaaaatag tatagcatat tttaacaaaa ccaaaaaagg ccctttccac 1728961 tggggaaggg cctttttcat catgttaact cctgagattc gccgaagctt tctctttttt 1729021 tggccaaata aaatagctgg ctgtaatgag aaagtcaatg cctataatga cagtccacag 1729081 tttaagaatg ccgctcaacg cctcggttcg ggaagagtca ttgataaaat agatcatccc 1729141 tgccaatagt cccgcaccaa ttaagtaggc cagcacatgt cttagccagc ctttcgcacc 1729201 gtgcttggca tggtccattc caaaacgttt cagcggtttt gttccttttt ttgtcacata 1729261 atattgaaac ttttcatctg cccattgaat catttgtttc ccataagcga tcgatatacc 1729321 gatgtaaaca gctgcaatcc catgggctgc ggtcgctgag gctccgcggt aaaggtccac 1729381 accagttgcc gctaacaaga tcaaatcgat aactggagtt aaggcaagga atagcagtcc 1729441 taatgtatgt cgtttgaata cgtagcgtac agcaagcccc aaaacaatga caacccaaaa 1729501 cgcaatttca cagaaaacaa tcatccatgc gataccgttc aatccattcc cctcttttca 1729561 atacagttgt attatttaaa taatatgtta ccatctttgt ttttgtaaca caactgtatt 1729621 ataaaaattg ccctctcatt tttttcttgt tacaataaag ctatgccaaa acaaattgac 1729681 catgagaaaa gaagaaaaca aattgcagaa gcaacgtggc gcgtcatttt agaacgaggg 1729741 atggagggag catcagccag aaatattgca aaggaagcag gattgtcatt aggtgcgctg 1729801 cgccattatt tctctacaca ggatgaattg cttgcttttg caatgaaact tgtccaagaa 1729861 aaggtaacgg accgaattaa ggacattgca gtgagggatt tgctccctaa ggaaaaagtg 1729921 ttgcaaattt tgcttgaaat ggtcccaacg aatgaagaaa cgattagaga gatggaggtt 1729981 tggtttgctt ttactgctta cgccagacat aaaaaggata tgtttgatgc gagtcatgac 1730041 gggattttca gcggcatgcg gaatctgatt gcctatttag atgaatccga tttactgaag 1730101 cagaatgctg ataaagacat tgaagctgag agactttacg cgcttgttga cggcttggct 1730161 ttacatgcca tgcttgaccc tgtgcgcgtg aataaagacc gaatcaagcg ggtcattatg 1730221 cagcatgtag agtcaatttg cgtggaagat acacgtgaga cacaaaaacg acatccttaa 1730281 ggcactagtg tgaaaagcga ttcttgttgg gcatgcgtcc aaaagagtcg cttttttatt 1730341 ttcaaagaac aaggatctct gaaaaaaatg gaaaacaatc atgctgtttg gtaaagtgga 1730401 atgaaagacg gactgagggg tgaacactgg tccatcgttt aagaacttta catgataggg 1730461 atggtataaa tgaatcttac ttacaaggtg catccaatta aaacaaggta tcagggctgg 1730521 acgaattatt gctatatcat tgaagatatt gtaagcagat ctgcaattgt tgttgatccc 1730581 tcatgggaat tgagtaagat aaccactaca ctttccgaac tcgaagcgga attaaaggca 1730641 gtcgcattga cacactctca ttatgatcat gtaaatctgg tagacccgct gacgaagatg 1730701 tttaacgctc aagtttatat gtcgaaaaaa gaaattgatt attatcaatt ccgatgcaga 1730761 aatttaatta gcctagatga tcatcagacg atcagcatag gaaacacaag agcacagtgc 1730821 cttctcacac cggggcatac agccggcgga atgtgttatt tgttttctga gagtattttt 1730881 accggagata cggtgtttac agaagggtgc ggcatatgtg aggatgatgg cagctctgcg 1730941 gaagagatgt ttgatagcat tcaaagaata aagtcggagg tttcacccca tgtacgggtg 1731001 tatcctggtc actcatttgg caaatcgccc ggccattcga taaaggatct ttatcagcat 1731061 aatatttact ttcaaattga taagaaagaa tattttgtga aatttcgcac tcgtaaaaac 1731121 caaaaaggta tttttgattt taaataatcc ttctgaatct attatcctat ttttcttcga 1731181 atatctaaat gatttttatt ttcgaaaatg attacataga aggtgttatt tattttgaaa 1731241 actcatttga aagaaaatga agcgcattat catgatatgg cgccctatat gtaatccggg 1731301 tcttttttct tatgttctgt tatatctcct gatcctttat tcctcaatgg aaaaaagcag 1731361 aaaaacaatg gagcaaactg taggaaaaat taacttgacg gataatattt acagaggtta 1731421 ccatcaacat gaacatgcta ctatttatcc ggtcatcact attataaaat catacagaag 1731481 tgaaacacat ctactaatcg gaagggtggc tttgagagaa tgatcacata tgtttttcca 1731541 ggtcagggtt cacaaaaaca gggaatgggc agcggcctat tcgatgaatt taaagaactg 1731601 acggatcagg cagatgagat cttaggatat tctatcaaac gtctttgcct ggaaaatcct 1731661 tattccaatt taaacaaaac gcaatttact cagccggcat tatatgtggt aaacgcacta 1731721 agctatctga aaaaaatcag ggatgaagaa gttaaacctg actttgtcgc cgggcacagc 1731781 ttgggtgaat acaatgcgtt atttgcagct gaagcctttg attttgagac aggtttacag 1731841 cttgtcagaa aaagaggcga gctgatgagt ctgataagca acggcggtat ggcagctgtt 1731901 atgggactaa atgaagagca ggttgcaaag gctctgaaag aatatcattt acatgatgtt 1731961 gatatcgcta atgtgaatgc cccatatcaa attgtaattt caggaaaaaa agatgagatt 1732021 gaaaaagccg catctctttt tgaaacgatg actgaagtta caatggtact ccccttaaac 1732081 gtaagcggcg cgtttcattc cagatacatg aataaagcaa aagaagaatt cgaggagttc 1732141 cttcatgcct tttatttttc gcctccgtct atcccggtta tttctaatgt gtatgccaaa 1732201 ccgtatacat acgaattcat gaaacagacg ctggctgatc aaattaatca ttcagtgaaa 1732261 tggactgaca gcataagcta cttaatgaaa aaaggccata tggagtttga ggaggtaggg 1732321 cctggaaatg ttttaactgg gttaattcat cgcataaaga aagatgcgga agcaatgccc 1732381 cgctaaagca tttgccccta tggccatgta tctcatcaat caggtctaaa cacagatttc 1732441 ctttcattta aggtataaag ttttaaagat tcaatcgttc gattgacact gtttctaatt 1732501 gaataacttt atatactgtt acataaagag gctgataaat taagttagac atttgaacta 1732561 tgtcagccgg tctgtcaaac catcgctccc acatctagat ggtccatttt taaaccgcac 1732621 ccaccaatca tagagtcgat gttctttgct gatcctgtta tcatgttaca tcaattttga 1732681 gatatcaaca tacatctacg atcacgtcat aaatgaacca catccagagc accaatagca 1732741 atccttccaa gttgaatctc ctttactttt tcacatatgt cttttccatt tattaatttc 1732801 atttcaatcg ctgctatgtg ctttaacaac atgcatggaa atgagaaatc caatagccgt 1732861 cataaatata aaaaaagaag gttatacaca tgaatgaacc gcttgttttt atgttttccg 1732921 ggcaaggttc ccaatactat cacatgggga aagaactatt taaggaaaat accgtgtttc 1732981 gccaatcaat gcttgaaatg gatgccattg cagcacggcg aatcggcaca tccattgttg 1733041 aagaaatcta ccatccaggt aaacgtgtgt cagatccgtt tgacagtatt cttttttccc 1733101 accccgccat ttttatgatt gagtattcct tatataaggt tttggaagac aggggaattt 1733161 atcctgatta cgtattggga tcaagtctgg gagaattcgc agcagcggca gtttctggtg 1733221 tgtcagacgc agaggatatg ctggattgca tacttgaaca ggctattatc atccagaatt 1733281 cctgcgataa aggaaaaatg ctggccattc ttgacaaacc gcaattgctg aatgatcatc 1733341 cgcaactgtt tggaaatagt gaactcattt ctatcaatta tgattcgcac ttcgtcattt 1733401 ctggtgaaga agatcatata aggaagatta tggaggattt aaaggagaag cagattcttt 1733461 gccagctgct tcctgtgtcc tatgcctttc attcttcgct tattgatccg gcagagagtg 1733521 cctatgcaga atttttaaga tcaaaatctt ttcaaaaacc gtcaataccg attgtatcga 1733581 gcttaacggg aagctgcctt cacgtaatgg acgagaattt cttttggaat gcggtcagaa 1733641 agccaatgat gtttcgtgaa gcgattcgat atttggaaag ccagcataca tgcaagttta 1733701 tcgatttagg gccatccggc accttagctg cttttgtgaa acagctgatt ccgggtgatt 1733761 cagctgaccg ttgctgctca atcataacac catttcatca ggagctgaaa aatctgaata 1733821 cggttgagta tttccgtaca ccagaaagga agtttacaag atgattacat atgtctttcc 1733881 agggcaaggc tcccagcaaa aggggatggg acaagggcta tttgaacagt atcagcattt 1733941 gacagatcaa gcagatcaaa tattgggcta ttcaatagag aagctatgta ccgaaaaatc 1734001 atatctggat gtaaatcata ctgaatacac gcagccggct ttgtatgttg ttaatgcact 1734061 cagttacttg aagagagtgg aggagaccgg cagaaaacct gattttgcgg caggacacag 1734121 cttaggagaa tacaatgcgc tgatggcagc cggtgcattt gattttgaaa ccggattaag 1734181 gctcgtcaaa aaaagaggag aattgatggg acgaattaca gggggcggaa tggctgctgt 1734241 gatcggcctg agtaaggaac aagttacagc cgttttagaa gagcaccgtc tttatgacat 1734301 tgatgtggca aatgaaaata cgccccagca aattgtgatt tctggcccga aaaaagagat 1734361 tgaaaaagct cgggctgttt ttgaaaacac caaggatgta aagctgtttc atccattaaa 1734421 tgtgagcgga gcttttcatt ccagatatat gaatgaagcc aaacaggtat ttaagcaata 1734481 tattgactca ttccagtttg cacctttggc gatcccggtt atctccaatg tctacgcaga 1734541 gccataccat caagacagat taaaagatac attatctgaa caaatggaca acacagtgaa 1734601 atggacggac agcattcgtt ttctgatggg aagaggagaa atggagtttg cagagattgg 1734661 gcctggaact gttttaaccg gtctcattca tcggattaaa aatgaagctg aaccattgac 1734721 atatataccg aaaaagaacc ccgcgatcag tgcgcatcta aaggagcaac gcaatgttca 1734781 agccgggatt acggcagaat ctttaggaag tgctgaattt aaacaagatt atcatcttac 1734841 atatgcttat cttgcaggag gaatgtaccg cggcattgct tcgaaagaaa tggtagtaaa 1734901 gctgtcaaga gcgggaatga tggggttctt tggcacagga ggtctgagcc tgaaagaggt 1734961 tgaagatgcg atccatgcta tacaaggtga attaggaaaa ggacaagcct acggcatcaa 1735021 tctggtccac aatatgaaac atactgaatc agaagaaaaa atgatcgatc ttttattgag 1735081 gaatcaagtg agcattgtgg aggcttcagc atttttaagt gtcactcctg tattagtaag 1735141 gtatcgcgca aaaggagtga aacgaaatca aaatggtgac gttatatgct caaatcgtct 1735201 catagcaaaa atatcacggc cggaagttgc agaatcattt ctgagtcctg cgcctgagaa 1735261 tatgctgcaa aagcttttag gagaaaataa aatcactatg aacgaagctg agttgttgcg 1735321 gtgcattccg atggctgacg atatttgtgt agaagctgat tcaggcggtc atacagatgg 1735381 cggtgtggca tacagcctga tgccggcgat gacatcttta agagatgaaa tgatgaaaaa 1735441 atatcaatac cggaaaaaaa taagagttgg tgcagctgga ggaattggaa cacctgaggc 1735501 agcgatggcg gcttttatgc taggggctga ttttattcta acaggctcaa tcaatcaatg 1735561 tacggttgag gcggcaacaa gtgataaagt aaaggatttg cttcagcaga tgaatgtaca 1735621 agatacagcc tatgcgcctg caggtgatat gtttgaatcg ggcagtaaag tgcaggtgct 1735681 aaagaaaggc gtgttctttc ccgcacgggc aaacaagtta tatgaactgt atcagcggta 1735741 tgggtctata cgtgagctgg atgcaaagat gctggcccag cttgaggaga aatactttaa 1735801 acgcagtata gaagacatat ataaagatat tgcattgcat tatcccgcgg cagacattga 1735861 gaaggctgaa caaaacccga agcataaaat ggctttgatt ttccgatggt acttcagata 1735921 cagttcaaaa ttggcaatca gcggaagcga acattcgaag gtcgattatc aaattcactg 1735981 cggtcccgcg ctgggagcct ttaatcaatg ggttaaaggg tcgcaattag aaaattggcg 1736041 aaaccgccat gtggatgaaa tcgggaaaaa attaatgaca gaaacggcag tattgcttca 1736101 tgaacggatg caatcgatgt atcagccgtc gcatgaaaca gacaacataa aaataaaagt 1736161 ttgaatatta tgaaaatata cctataaaaa tcattaaaat aatcccttga aggagagagc 1736221 gcattatgga taaacagaga atctttgaag tattaatcac caatatttgc gaggtgcttc 1736281 ctgaattaga cggacacaga tttgagcctg aagatcagtt agttgagcta ggagctgact 1736341 ctgtagacag agctgaaatt atcacgatgg tgctagagga tttatcgtta aaaatccctc 1736401 gcattgagct atccggggtg aaaaacatcg gtgaattagc tgaggtgctt tatgacaaag 1736461 tgcaatctgc ctgaggtggt ggtgaccggt gtaggcgtta cggcctctat cggtcaaggg 1736521 aaagaggact ttgcttcctc gctgctgtcc ggcagacatg cctttgatgt catgaagcgt 1736581 tcaggcagac aaaaagacag ccggtttatc ggagccgaaa ttgcgtcatt gtcttatcct 1736641 gaccgactct ctaaaaaaat gttgcgaaaa gcatcattct ccagccgcgc tgcattggta 1736701 actctcacag aggcttggga ggaggctgaa ttggacgatg cagattcctc acgtatcgga 1736761 ctggttgttg gcggatcaaa ttttcaacag agagaaaact ttgaagttta tgaaaggtat 1736821 caagaccgct ccggttttat ttctccggcg tatggtctgt ctttcatgga cagcgatctt 1736881 tgcgggatat gtacagatca gtttggcatc acgggattag catatacggt gggaggagct 1736941 tcggccagcg gccagttagc agtcattcat gcgattcagc aagtcctgtc aggcgaagtt 1737001 gatacttgca tagcacttgg tgctttaatg gatctttctt atatggaatg cgaggcgcta 1737061 agggctttag gcgctatggg gacggacaaa tatgctgatg aacctgaaaa tgcgtgccgt 1737121 cccttcgatc aaaacagaga cgggtttatc tatggagaat cgtgcggtgc attggtaata 1737181 gaacgaaagg agacggcttt acgaagaggt ctaaaacctt atgcagcatt gtctggctgg 1737241 tcaatcaaac tggacggaaa ccggaatcct gatccttcat tagaaggaga gattcatgtc 1737301 atccagaagg cactggagcg tgccaggctt ttaccagaag atattgatta tattaatcct 1737361 catggaacag gctcttttat tggagatgaa atagaattaa aggcgctccg tgcatgccgg 1737421 ctttcccatg cttatatcaa tgcaacaaaa tcgataaccg gacacgggct tagtgcggcg 1737481 ggcatcgtag agattatttc tgttttgctg caaatgaaaa aatctgccct gcatccgagc 1737541 aggaatttgg atcatccaat cgatgattcc tttcattggg taaatgagaa atcgatttca 1737601 taccgcatca aaaatgcgct gagcttaagc atggggtttg gcggaatgaa caccgcggtt 1737661 tgtatacaaa acattgagaa atgtggaggc gaatcataaa tggtttcagc cggaatagaa 1737721 gcgatgaatg tctttggcgg aacggcatac cttgatgtca tggagctggc caaatacaga 1737781 cacttagata ctgcgagatt tgaaaattta ttaatgaaag aaaaagcggt agcactgcct 1737841 tatgaagatc ccgtgacctt cggagtcaat gcagctaagc cgattattga tgctttatct 1737901 gaagcagaga aggaccggat tgaattgctg atcacttgct ctgaatccgg gatcgacttt 1737961 gggaaatcgt taagtacata tatccatgaa tatttaggtc tcaaccgcaa ctgccgtttg 1738021 tttgaggtta aacaggcgtg ttattcaggg acagcgggat ttcagatggc ggtgaatttt 1738081 atattatccc agacttctcc gggtgccaaa gcactggtta tcgccagtga tatttcacgt 1738141 tttttaatcg ctgagggcgg agacgcttta agcgaagatt ggtcttatgc ggaaccgagc 1738201 gccggagcgg gagcggtggc cgttttagtt ggcgaaaatc ccgaggtgtt tcaaatagat 1738261 cccggagcaa atggttatta cggctatgaa gtgatggaca cgtgccgccc cattcccgac 1738321 agtgaagcgg gagattctga tctgtcttta atgtcatatt tggattgctg cgaacagact 1738381 tttctggaat atcaaaagcg tgtaccgggt gccaattatc aggacacgtt tcaatatctt 1738441 gcttaccata cgccctttgg cgggatggtg aaaggtgcgc accggacaat gatgcgtaag 1738501 gtagcgaagg tgaaaacatc cgggattgag acggattttt taactcgggt aaaaccaggt 1738561 ttaaactact gtcaacgggt tggaaatatt atgggggcag ccttgtttct ggcattggcc 1738621 agcacgatag accaagggag atttgatacg cctaaacgaa ttggctgttt ttcctacgga 1738681 tccggctgct gttctgaatt ttacagcgga attacaactc cgcaaggcca ggagcgtcag 1738741 cgaacatttg gtattgagaa gcatttggat cgccggtatc agctctccat ggaagagtat 1738801 gagctattgt ttaaggggag cgggatggtg cggtttggga cgcgcaatgt aaagctggac 1738861 tttgagatga taccgggcat catgcagtcc actcaagaga agccgcgctt gtttttagaa 1738921 gaaatttctg agtttcatcg gaagtacagg tggatctcgt gacctatcaa acgataaagg 1738981 tccgctttca agcatcggtt tgctatatta cctttcaccg tcctgaagcg aataatacga 1739041 ttaatgacac gctgatagaa gaatgcttgc aagtgttaaa ccaatgtgaa acatcaacgg 1739101 tgacggttgt cgttttagag gggcttcccg aggtgttttg tttcggagcg gattttcaag 1739161 aaatctatca ggaaatgaaa aggggcagaa aacaggcaag ctcccaagag cctctctatg 1739221 atttgtggat gaaattgcag accggccctt atgtcacgat ttcgcatgtc aggggaaaag 1739281 tgaatgccgg cggtcttgga tttgtatctg ccacagatat tgccattgct gatcagacgg 1739341 cgtcattcag tctctctgag ctgctattcg gcctgtaccc tgcttgtgtt ttaccgtttc 1739401 tgatccgccg tatcggccgg cagaaagcgc attatatgac gcttatgaca aagccgattt 1739461 ccgttcagga agccagtgaa tgggggttaa tagatgcttt tgatgctgaa agtgacgtgc 1739521 tgctgagaaa gcatttattg cgtttgcgga ggctgaataa aaaaggaatc gcacattata 1739581 aacagtttat gagctcactt gatcatcaag tcagtcgtgc gaaagccacc gctttaactg 1739641 caaatcaaga catgttttct gatcctcaaa accaaatggg aatcatcagg tatgttgaaa 1739701 caggacaatt cccatgggag gatcagtaac cgtttaaaaa tgacaatcag aaccgttagg 1739761 aggacatcat gacgcattct gttgtagagc ttatcgaaat tgaatccgcc attattcagg 1739821 taaagatgca agatcgcact cataaaaacg cgttttcaca agaacttaca gacgatttaa 1739881 ttcaagcgtt tgaatacata cggcagaatc ccaaatacaa agcggtcatt ttgacaggat 1739941 atgataatta ttttgcttca ggaggaacgc aagaaggact gcttcgaatt caacagggat 1740001 tgaccaagtt cactgatgac aatctttatt ctctggcgct ggattgcgag attccagtta 1740061 ttgcggcaat gcagggccat ggaattggag gcggctttgt catggggctc tttgctgaca 1740121 ttgtcattct gagcagagaa agcgtgtata cggctaattt tatgaaatac ggatttacgc 1740181 ctggaatggg cgctaccttt atcgttccta aaaaactggg tttcagcctg gcccaggaaa 1740241 tattattgaa tgcgggcagc taccgcggag ctgatcttga aaaaagaggg gttcctttta 1740301 aggtgctgcc ccgtgcagaa gtgttagatt atgcagtgga gctggcgcaa gaactggcgg 1740361 aaaagccgag aaactcactg gttacactga aagatcattt ggttgccccg cttcgcgatc 1740421 agctgccgcg cgtcattgaa caggaattga tgatgcatga gaaaacattt catcatgaag 1740481 aagtcaaaag tagaatcaaa ggtttatatg gtaattaact gaaaatatat ataaattttg 1740541 caggtgaaat ggaggcagcg tgatgagaaa taatgataat atccgcatat taactaatcc 1740601 ttctgtcagt catggggagc ctttacatat atctgaaaag cagccggcaa caatacctga 1740661 agttttatac agaacggcga cggagcttgg ggatacaaag ggaatcattt atttgcagcc 1740721 ggatggaact gaagtttacc aatcatacag acgattatgg gatgatggat tgcgcattgc 1740781 gaaggggctt cgccaatcag gcctgaaagc aaaacaaagc gtgattttgc agcttggtga 1740841 caattcacag cttctccctg cgttctgggg gtgtgtgtta acaggggttg ttccggctcc 1740901 attagccgtt ccgccaacgt atgctgaatc gagcagcggc actcaaaagc tgaaagacgc 1740961 atggacgctt cttgataagc cagcggtgat tacggaccgg gggatgcatc aggaaatgct 1741021 cgattgggca aaagaacaag ggcttgaagg gttcagggca attattgtag aggatctgct 1741081 cagcgctgaa gcggacacag attggcatca atccagtcct gaagacttag cgcttttatt 1741141 gctgacttca ggcagtacgg gaacgcccaa agcagttatg cttaatcatc gtaacattat 1741201 gagcatggtg aaagggatta ttcaaatgca aggcttcacc agagaggata ttacgtttaa 1741261 ctggatgccg tttgaccatg tcggagggat cggaatgctg catttgcggg atgtttatct 1741321 tggctgtcag gaaattaacg tctcaagcga aacgatctta atggagccgt tgaaatggct 1741381 ggattggatt gatcattacc gagcttctgt tacgtgggcg ccgaattttg cgtttggtct 1741441 ggttactgat tttgcagaag aaataaaaga taagaaatgg gatctgtctt caatgcgata 1741501 catgctcaat ggcggtgaag caatggtagc caaggtaggg cgtagaatac ttgagctttt 1741561 agaaccacat ggactgcctg ctgacgccat ccgacctgcc tggggaatgt ccgaaacttc 1741621 atcgggcgtt attttttctc atgaatttac ccgggctgga acaagtgatg atgatcattt 1741681 tgttgaaata ggctctccaa tccccggctt ctctatgaga attgtgaatg accataatga 1741741 attggttgaa gagggtgaga tcggccgttt tcaagtctcg ggtctttctg ttactagcgg 1741801 ttattaccag cggcctgatt tgaatgagag tgtgtttaca gaagacggct ggtttgaaac 1741861 cggagatctt ggctttttgc gaaacgggcg cttaaccata acaggccgta cgaaagatgc 1741921 aattatcatt aacggcatta attattacag tcatgcaatt gagtctgcag ttgaagaatt 1741981 acctgaaatt gaaacttctt atactgctgc ttgcgctgtc cgtctgggcc agaattcaac 1742041 agatcagctg gctatcttct ttgttacttc cgcaaaatta aatgatgagc agatgtctca 1742101 gcttcttaga aacatacaat cccatgtctc acaggtgatc ggagtcaccc cggaatattt 1742161 gctgcctgta caaaaagaag agattccaaa aacggctatc ggaaagatcc agcgcaccca 1742221 gctaaaaact tcatttgaaa atggagagtt cgaccacttg ctacataaac ccaatcggat 1742281 gaacgatgca gtccaggatg aggggataca gcaagcagac caggtgaaaa gagtaaggga 1742341 agaaatacag aagcatctgc tcacctgttt gactgaggag ctgcacgttt cccacgattg 1742401 ggtggagcca aatgcaaata tccaaagtct tggtgtgaat tctatcaaga tgatgaagct 1742461 cattcgatcg atcgagaaaa actatcatat caaactaaca gctagagaga tacatcaata 1742521 tcctacaatt gaacgcttag ccagctatct atcagaacat gaagacctca gcagcttgtc 1742581 tgctgacaaa aagggcacgg acacatataa aaccgaaccg gaaaggagtc aggcaacttt 1742641 tcagcctctc tctgaggttc aaaaaggatt atggacattg caaaaaatgt cacccgaaaa 1742701 aagtgcatat cacgtacctc tctgttttaa attttcgtca gggcttcacc atgaaacatt 1742761 ccagcaggct ttcggccttg tattgaatca gcacccaatc ttaaagcacg tcatccaaga 1742821 gaaagacgga gtgccatttc ttaaaaatga gccagcactt tcaattgaaa tcaagacaga 1742881 aaatatctca agtttgaaag agtctgatat tcctgctttt cttagaaaga aagtaaagga 1742941 accgtatgta aaggaaaaca gcccgttagt gcgtgtcatg agcttttcca gatctgaaca 1743001 agagcatttt ttattagttg tcattcacca tttgattttt gacggagttt cgtctgtcac 1743061 atttatacgc agtctgtttg atacctatca gcttctttta aaaggacagc agccggaaaa 1743121 agctgtttct cctgccattt atcatgattt tgcggcatgg gagaaaaaca tgcttgccgg 1743181 caaagacggt gtgaagcacc gtacatattg gcagaaacag ctatcgggaa ctttgccgaa 1743241 tcttcagctg cctaatgtca gcgcaagttc agtcgattct cagtttagag aggatacata 1743301 caccaggcgg ttgtccagcg gcttcatgaa tcaggtcaga acgtttgcga aagagcattc 1743361 tgtaaatgtc acgacggtat tcttaagctg ctatatgatg ctgcttggcc gttacacagg 1743421 ccaaaaagaa cagatcgtcg gcatgccggc catggtgagg ccggaagaaa gatttgatga 1743481 tgccattgga cattttctca atatgctccc gattcggagt gagctgaacc cggcagacac 1743541 tttttctagc tttatatcaa aattgcaatt aacgatattg gatgggcttg atcatgcagc 1743601 atatcctttt ccaaaaatgg tgagggatct gaatattcct cgcagtcaag caggttcacc 1743661 ggtatttcaa accgcttttt tctatcagaa ttttcttcaa tccggaagct atcaaagctt 1743721 gctgagccgc tatgctgact tcttttctgt cgatttcgtt gagtatattc accaagaggg 1743781 cgaatacgaa ttagtatttg aactgtggga aacagaagaa aaaatggagc tgaacatcaa 1743841 gtacaatact gggctgtttg atgcggcttc tatatccgcc atgttcgacc attttgttta 1743901 tgtaacagag caggcgatgt tgaatccttc tcagccttta aaagagtatt ctttattacc 1743961 tgaggcagag aagcagatga ttctcaaaac atggaacgcc acaggaaaaa cgtatccata 1744021 tataactttt catgagttgt ttgagcagca ggcgaaaaag acgcctgata gagcggctgt 1744081 cagctatgaa ggtcaaacat tgacgtatcg ggagcttgat gagaaaagca cacagctggc 1744141 catttatttg caggcgcatg gagtgggtcc tgaccgtctg gcggggatct atgtggatcg 1744201 atcgctggac atgctagtgg gtttattagc gatcctcaag gctgggggag cgtatgtgcc 1744261 gctagacccg tcctatccgg ctgaacgatt agaatacatg cttgaggaca gtgaagtttt 1744321 cattacactg acgacatcgg aattagtaaa tacgttgagt tggaacggtg tcacaacagc 1744381 ccttttagat caagattggg atgaaattgc tcaaacagcc tctgatcgaa aagtgcttac 1744441 acgcactgtc acgccagaga acttggcata tgtcatttat acatccggca gcacaggaaa 1744501 gccaaaaggt gtcatgatac cacataaagc tttgacaaac tttctcgttt cgatggggga 1744561 aacaccaggt cttacggcag aggataaaat gcttgctgtc acaacctact gttttgatat 1744621 tgcagctctg gaattatttt tgcctttaat aaagggcgca cactgctata tttgtcaaac 1744681 ggagcataca aaagacgttg aaaaactgaa acgggacatc cgcgcgatca aaccgacagt 1744741 gatgcaggca acccccgcta cgtggaagat gctcttttat tcaggctggg aaaatgaaga 1744801 gagcgtgaaa attttatgcg gtggcgaagc attgcctgag acattaaaac gatatttctt 1744861 agatacgggc agcgaagcct ggaatatgtt cgggccaacc gaaacaacta tctggtcagc 1744921 ggttcagcgc attaacgttg aatgctctca tgccacgata ggaaggccaa tcgccaatac 1744981 acaaatctat attacggatt ctcagctcgc gccagtgccg gcaggtgttc cgggtgagct 1745041 gtgcattgca ggagacggtg tggcgaaggg ctactacaaa aaggaagaat taacggattc 1745101 gagattcatt gacaaccctt ttgagcctgg gtctaagctt tatagaacgg gagacatggc 1745161 ccgttggctt acgggagggc gaattgaata tataggccgc atcgataatc aagtaaaaat 1745221 ccgcggattc cgtattgaac ttggtgatat tgaaagcagg cttagtgagc atcccggcat 1745281 tctggaatgc gttgtggtcg cagatatgga taacctagct gcctattata cagctaaaca 1745341 tgcaaatgct tctctcacag cgagagagct gcgtcatttt gtgaaaaacg ctttgcctgc 1745401 ctatatggtg ccttcttatt ttattcagct tgatcatatg ccgttaactc cgaacggaaa 1745461 gatagataga aacagcctta agaatatcga tttatcaggg gagcagctaa agcaaaggca 1745521 gacctctcct aagaacattc aggatactgt ttttaccatt tggcaggaag tgctgaaaac 1745581 gagtgacatt gaatgggatg acggattttt cgatgtgggc ggggattcgc ttctcgcggt 1745641 cactgtggct gatcgtatca aacatgaact atcctgtgag ttttctgtca cagacctgtt 1745701 tgagtattca acgattaaaa atatcagcca gtacatcact gaacagcgaa tgggcgatgc 1745761 aagtgaccat ataccgacag acccggcagc tcatatagaa gatcagtcta ccgagatgag 1745821 tgatctcccg gactattatg acgatagtgt ggcgattatt ggcatatcgt gtgaatttcc 1745881 aggggcaaaa aatcatgatg aattttggga gaacctcaga gacggcaagg aaagcattgc 1745941 gtttttcaat aaagaagagc ttcagcgctt tggcatttca aaggagatag cggagaatgc 1746001 cgactatgtc cctgctaaag cttcaattga tgggaaagac agatttgatc caagcttctt 1746061 tcaaatctct cctaaagacg ctgaatttat ggaccctcag cttcggatgc tgctgactca 1746121 ttcatggaaa gcaatagaag atgccggtta tgctgcgagg cagattccgc aaaccagtgt 1746181 ttttatgtcg gcaagcaata attcttatcg cgcgctgctg ccgtcagata caacagagag 1746241 cctggagacg ccggacggct atgtttcgtg ggtgcttgca cagagcggga cgattccgac 1746301 aatgatttct cataagctcg ggctgagagg gccaagctat tttgtccatg ccaactgctc 1746361 atcctctctg attggattgc attctgccta taagagcctc ctgtcgggtg aatctgatta 1746421 tgctttagtt ggcggtgcaa cgctgcatac cgagtcaaat atcggatatg tgcatcagcc 1746481 tgggctgaac ttttcgagtg atggacatat taaagctttt gacgcttcag ctgacggaat 1746541 gataggcggt gagggcgttg ctgttgtatt gctgaaaaaa gcagctgatg cagtaaagga 1746601 cggggatcat atctatgcct tgctgagagg cattggtgta aataacgacg gcgctgacaa 1746661 agtcggcttt tatgctccaa gcgttaaagg ccaggctgac gtggtccaac aggtcatgaa 1746721 tcaaacgaag gtacagcctg aatccatctg ctatgtagaa gcacacggga ccggaacgaa 1746781 gctgggggac ccgatcgagc tggcggcttt aacaaacgtt tacaggcaat atacaaataa 1746841 aacgcaattt tgcggcattg ggtcggtgaa aaccaatatc ggacatttag atacagccgc 1746901 cggtcttgcg ggctgcatta aggttgtgat gagtctttat catcaagagc ttgcaccgag 1746961 tgtcaattat aaggagccga atccaaatac agacttagcc agctctcctt tttacgtcgt 1747021 cgatcaaaag aaaacgttaa gccgtgagat caaaacgcac agggctgcac ttagctcgtt 1747081 cgggcttggc gggacaaata cccatgccat ttttgaacaa ttcaaaaggg attcagataa 1747141 gggaaagata gacggaacct gcatcgtccc gatctcggcg aaaaataaag agaggctgca 1747201 agagtatgca gaagacattc tggcctattt agaaagaaga gggtttgaga acagccagct 1747261 gcctgatttt gcgtataccc ttcaggtggg gcgcgaagcg atggagcatc gcgttgtctt 1747321 tattgccgat catgtaaatg agttaaaaca gaggctcaca gattttatca atggaaatac 1747381 agcgattgaa ggctgttttc aaggaagtaa gcacaatgcc agagaggttt catggctgac 1747441 ggaggatgag gacagcgctg aactcatacg taagtggatg gccaaaggaa aagtaaacaa 1747501 gcttgcagaa atgtggagca agggagcgca tatagattgg atgcagcttt acaagggaga 1747561 gcgcccaaac agaatgagtc tgccgactta tccatttgca aaggaacgat actggccgtc 1747621 gcaggatgac cgcaaaccgg tggcgcagat atccggaaat cagacaggga tcggctctat 1747681 tcatccattg cttcatcaga atacatctga tttttctgaa cagaaattca gttcggtttt 1747741 cactggtgac gaatttttcc tgagagacca tgtggtaaga ggaaagcctg tgcttcctgg 1747801 tgttgcgtac cttgaaatgg cgtacgcggc tataaaccag gcggcaggaa gtgaaattgg 1747861 ccaagatgtc agaatcagat tgaatcatac agtctgggtt cagcctgttg tggttgacag 1747921 acattcagct caagtggata tcagtctctt tcctgaagaa gatggaaaaa tcacctttga 1747981 catttacagt acacaggaag acggggacga ccctgttatt catagtcaag gcagtgcgga 1748041 gctggcatct gccgccgaaa cgccagtcgc agatctcact gaaatgtcac gccgttgcgg 1748101 caaaggaaag atgtcgcctg atcaatttta cgaagaaggc agaagcagag gaatgttcca 1748161 tggtccggcc tttcaaggaa ttaagaatgt gaatatagga aacagagagg ttttggcgca 1748221 gctgcagctt ccagaaatcg tttctggaac gaatgaacag tttgtgctgc acccaagtat 1748281 catggattcc gccttgcaga cagcaacaat atgcatcatg caggaattga cggatcaaaa 1748341 gctgattttg ccatttgcgc ttgaggagct tgaagtgatc aaagggtgtt cttcttctat 1748401 gtgggcttat gcccgcttaa gtgacagcga tcactccgga ggggttgttc agaaagcgga 1748461 tatcgatgtc attgacgaga gtggaaccgt atgtgtcagg atcaaaggat tttcaacgag 1748521 agtattagaa ggggaggttc atacttcaaa gccttcaaca cggcacgaac gcttaatgct 1748581 tgaaccggtg tgggaaaaac agaatgaaga acgagaggac gaagatcttt cgtacacgga 1748641 gcatatcatt gttctcttcg aaactgaacg aagtgtcaca gacagcattg cctcccacat 1748701 gaaagatgcc cgtgtgatta ctctaaacga agctgtagga catattgctg aacgttatca 1748761 atgttacatg cagaacattt ttgaactcct gcaaagcaag gtccgtaagc tttctgcagg 1748821 ccgtatcatc attcaagcga ttgttccgct ggaaaaagag aagcaattgt ttgccggcgt 1748881 ttccggtctg tttaaaacag cagaaataga gttcagcaaa ctgactgctc aggtcatcga 1748941 aattgagaaa cctgaagaga tgatagacct tcacctcaag ctgaaagacg acagccggag 1749001 accatttgac aaacagattc gatatgaggc tggataccgt tttgtgaaag gctggaggga 1749061 aatggtgctt ccttcagctg atacgcttca catgccgtgg agagacgagg gtgtttatct 1749121 aatcacaggc ggagcaggaa gcttaggcct tctgtttgca aaggaaattg ccaatcgaac 1749181 tggccggtct actattgtgc tgacgggacg atctgtttta agtgaggata aggaaaacga 1749241 gctggaggct cttcgaagca tcggagcgga ggttgtctat cgagaggctg atgtaagtga 1749301 tcagcatgcg gttcgtcatc ttttggagga aatcaaagaa agatatggca ctctcaatgg 1749361 aattattcac ggtgcaggca gcagtaaaga tcgcttcatc attcataaaa cgaatgaaga 1749421 gtttcaagaa gtgttgcagc caaaagtgag cgggttgtta catgtagacg aatgcagcaa 1749481 ggatttccca ttggactttt tcattttctt ctcttctgtt tcgggatgtt taggaaacgc 1749541 tggacaagcc gattatgcgg cagccaattc gtttatggat gcatttgctg aataccgccg 1749601 ttctcttgcg gcatcaaaaa agagattcgg ctccaccatt tccttcaatt ggccgttatg 1749661 ggaagaaggc ggtatgcaag tcggcgctga agatgaaaag agaatgctga aaacgacggg 1749721 aatggtcccg atgccgacag atagtggctt gaaagcattt tatcaaggga tagtatctga 1749781 taagccgcaa gtttttgtga tggaaggaca gcttcagaaa atgaagcaaa aactgctttc 1749841 cgcaggatcg aaagccaagc ggaacgatca gagaaaggcg gatcaggatc aaggacaaac 1749901 tagaaaattg gaagcagcct taatccaaat ggttggcgca attttgaaag taaacactga 1749961 cgatatcgat gtcaacacag agctgagtga gtacggattc gactcagtta cattcactgt 1750021 ctttacaaac aagatcaacg aaaaatttca attggagcta acaccgacca tattctttga 1750081 atatggcagc gtccaaagcc tggctgaata tgtagttgct gcgtatcagg gcgaatggaa 1750141 tcaagatgct actgctaaag gcaaagatga aagaacaaac ttagtgcaca gtttaagcag 1750201 cctggaggca tcattaagca acatggtcag tgcaatttta aaagtaaata gtgaagatat 1750261 tgatgtcaat acagagctga gtgaatacgg atttgattca gttacattta cggtctttac 1750321 aaacaagatc aacgaagaat ttcagttgga gctaacgccg accattttct ttgaatatgg 1750381 aagcctccac agcctggctg agtatttgac cgttgaacat ggtgacaccc tggttcagga 1750441 gcgagaaaaa ccagaggggc aggaagagtt acagacaaaa tcttctgaag cgccgaaaat 1750501 cacatcacgt agaaagcgcc gctttacaca gcctattatt gcaaaagcag aaagaaacaa 1750561 aaagcaggct gccgattttg agccggttgc aattgtcggc atcagcggcc ggttccctgg 1750621 cgctatggat atagacgaat tttggaaaaa cctagaagaa ggaaaagaca gcatcacaga 1750681 agttccaaaa gatcgatggg attggcggga gcattatgga aacccagaca ctgacgtcaa 1750741 taaaaccgac atcaaatggg gtgggtttat tgatggtgtc gcagagtttg atccgttgtt 1750801 ttttggtatt tcgccgcgag aagctgatta tgtagaccct cagcagcgct tgttaatgac 1750861 atacgtgtgg aaggcattgg aagatgcggg ttgctcgccg caaagccttt cgggtacagg 1750921 gaccggtatc tttatcggta cgggaaacac cggttataaa gatctattcc atagagcgaa 1750981 tcttccaatt gaaggccatg ctgctacagg tcatatgatt ccttcggtag gcccgaatag 1751041 aatgagttat tttttaaata ttcatggtcc gagcgagcca gtagagacgg cttgttccag 1751101 ttctcttgta gccattcacc gtgctgtgac tgcgatgcaa aacggtgatt gtgagatggc 1751161 gatcgctgga ggcgtgaata cgatcttaac cgaggaggcg catattagct acagcaaggc 1751221 ggggatgctc agcacagacg gcaggtgtaa aaccttctcc gccgatgcga atggctatgt 1751281 cagaggcgaa ggggtcggaa tggtcatgtt gaaaaagctg gaagatgccg agcgcgacgg 1751341 aaatcatatt tacggcgtta ttcggggcac ggcggaaaat cacggcggaa gagccaatac 1751401 cctgacatcg cctaatccga aagcacaagc tgatttgttg gtgcgtgcat atcgccaagc 1751461 agacatagat ccaagcactg tcacatatat cgaagcacat ggaacaggga cggaattggg 1751521 cgatccgatt gaaataaatg ggctgaaagc cgcgtttaag gaactatcca atatgagagg 1751581 cgagagccag ccggatgttc cggatcaccg ttgcggcatc ggctcagtta aaagcaatat 1751641 cggtcattta gagctagcag ccggtatttc cggtttgatc aaggtgcttt tgcaaatgaa 1751701 gcataaaacg ttagtgaaaa gcctgcattg cgagacgctt aatccttatc ttcagctgac 1751761 tgacagtccg ttttacatcg ttcaggaaaa acaggaatgg aagtctgtca cagatcgtga 1751821 cggaaacgag cttccgcgcc gtgccggaat cagttcgttt gggattggcg gagtaaacgc 1751881 gcatattgtg attgaagaat atatgccaaa agccaattca gaacacacgg ctacagaaca 1751941 gccaaacgta attgtgctgt cggctaaaaa taaaagcagg ctgatagatc gtgcttcgca 1752001 attgcttgag gtgattcgca ataaaaaata tactgatcag gatttgcacc gcatcgctta 1752061 caccctgcag gtcgggcgcg aagaaatgga tgagcgtctg gcgtgtgttg cggggacaat 1752121 gcaggagctt gaagagaaac tgcaggcgtt tgttgacggt aaggaagaaa cagacgaatt 1752181 tttccgggga cagtctcatc gaaataaaga gacccagact atttttacag cagatgaaga 1752241 tatggcgttg gcacttgatg cttggatcag aaaaagaaaa tacgccaaac ttgctgattt 1752301 atgggtcaaa ggggtctcaa tccagtggaa cacattatac ggagagacca aaccgcgcct 1752361 gatcagcctc ccttcatatc cgtttgcgaa ggatcactat tgggtgccgg caaaggaaca 1752421 ttcagaaaga gacaaaaaag aactggttaa tgcgattgaa gatcgcgccg catgcttttt 1752481 gacgaaacaa tggagtttga gtccaattgg atcagcagtg ccggggacaa gaactgttgc 1752541 catcctgtgc tgtcaagaga cagcagattt agcagcagaa gtgtcttcgt attttccgaa 1752601 tcatctctta atagatgtga gccggataga aaatgatcag tcagacattg attggaaaga 1752661 gtttgacggc ctagtggatg tcatcggatg cggttgggat gatgagggcc ggctggattg 1752721 gattgaatgg gtgcaaagac tggttgaatt cgggcataaa gaggggctca ggctgctttg 1752781 tgtgacgaag gggctcgaat cgtttcaaaa cacatctgtc cggatggctg gcgcctcacg 1752841 ggctgggttg tatcgaatgc tccaatgcga gtacagccat cttatatcaa ggcatatgga 1752901 tgctgaggag gttactgatc atcgccgtct cgcgaagttg atcgctgatg agttttattc 1752961 cgattcttat gatgcggagg tttgctacag ggatggttta cggtatcaag cttttctaaa 1753021 agctcatccg gaaacaggta aggccacgga acagagcgcg gtcttcccga aagatcatgt 1753081 acttctcatt acaggcggca cacgaggcat cggactatta tgcgcccgtc attttgcaga 1753141 gtgctatgga gtgaaaaaac tggtgctgac cggacgagaa cagcttcctc cgcgagagga 1753201 gtgggctcgt tttaagacat caaacacatc attggcagag aaaatccagg cagtgcggga 1753261 gctggaagcg aagggtgtac aggtggagat gctgtcgctg acgttatctg atgatgctca 1753321 ggttgagcaa acgctgcaac atatcaagcg aacattagga ccgattggcg gtgtcattca 1753381 ttgtgcaggt ctgacggata tggatacgct ggcatttatc cgaaaaactt cggatgatat 1753441 ccagcgggtg ctggaaccta aggtgtcagg tcttacaacg ttatatcgcc atgtgtgtaa 1753501 cgagccttta cagttttttg tcttattttc ttctgtttca gccattattc cggagctttc 1753561 ggcgggacaa gctgactatg cgatggccaa tagctatatg gattattttg cagaagcaca 1753621 tcagaaacat gcgccgatca tcagtgttca gtggccgaac tggaaagaaa ccggtatggg 1753681 tgaagtgaca aatcaagcgt atcgggacag cggcttgttg agcattacga attcagaagg 1753741 cttacgtttt ctagatcaaa ttgtatcgaa aaagttcgga ccggttgttc tccctgcaat 1753801 ggcgaatcaa acaaactggg agccggaact gctgatgaag aggaggaaac cgcatgaggg 1753861 cggtttgcag gaagctgctt tacagagccc gccagccaga gacattgaag aggccgatga 1753921 agtttccaaa tgtgatggat tattatctga aacacagtcc tggcttattg atctgtttac 1753981 cgaagagctg agaatagatc gtgaagactt cgagattgac gggttgtttc aggattatgg 1754041 cgtggattcg atcattttgg cacaggtgct ccagcgtata aaccgcaaat tagaggcagc 1754101 gctcgatcca tcgattctat atgaataccc gacaattcaa aggttcgcag attggctgat 1754161 cggttcttat tccgaaaggc tgtccgcttt attcggaggc aggatatcgg atgcatcagc 1754221 acctttggag aacaaaatag aggcggaggc atctgttcct gggaaggatc gagctcttac 1754281 acctcagatt caggcgccag cgattttgtc accggactct catgcagaag gtattgccgt 1754341 tgtcggactc tcttgccgat tccctggggc agagacattg gagtcatatt ggtcgttact 1754401 atccgagggg cgttcgtcaa tcggcccgat tccggcagag cgttggggct gtaagacgcc 1754461 atattatgcc ggcgtgattg atggcgtcag ctattttgat cctgatttct ttttgcttca 1754521 cgaagaagac gtaagggcga tggatccgca agcactgctc gtgttggaag agtgtctgaa 1754581 gctcttgtat cacgccggtt atacacctga ggaaataaag ggcaagcccg tcggtgttta 1754641 tatcggaggc agaagccagc acaaacctga tgaagacagc cttgatcatg ccaagaatcc 1754701 gatcgtgaca gtcggccaaa attatttagc cgctaatctt tcacaatttt ttgatgtccg 1754761 cggtccaagt gttgtagttg acactgcatg ctcgtcagct ttggtcggca tgaatatggc 1754821 cattcaggcg ctgcgtggcg gagatattca atccgccata gtcggcggtg tcagcttgct 1754881 gagctcagat gcgtctcaca ggctgtttga ccggcgcggc attttaagca agcattcatc 1754941 cttccatgtg tttgatgagc gtgctgacgg agttgtgtta ggtgaaggcg tcggaatggt 1755001 catgctaaaa accgtaaaac aggcactgga agacggagat atcatatatg ctgtcgtcaa 1755061 agcggcctcg gtcaataacg acggaagaac ggcgggacct gcaacaccta atcttgaggc 1755121 acaaaaggaa gtcatgaaag atgcgctttt caaaagcgga aaaaaaccag aggacatcag 1755181 ctaccttgag gcaaacgggt caggttcaat cgtaaccgat ctccttgagc taaaagcgat 1755241 ccaatcagtg taccgttctg ggcactcatc gcctctttct cttggctcaa tcaagccgaa 1755301 catcgggcat ccgctatgtg ctgaagggat cgccagcttc attaaggttg tgctgatgct 1755361 gaaagagcgc cgctttgtcc catttttatc aggtgaaaaa gagatggcgc atttcgatca 1755421 acagaaagcg aacatcacgt tcagccgagc cctggaaaaa tggacagatt cgcagcctac 1755481 tgcggctatt aactgctttg ccgatggggg gacgaatgcc catgtcatcg tagaggcgtg 1755541 ggaaaaagat gaaaaacacg ccatcaagcg cagtccaata tcgcctcctc aattaaagaa 1755601 acgaatgctt tcgccaggcg agccaaagct ggaagcggag acttcaaaaa tgactgcggc 1755661 aaacatatgg gatacttatg aggtggaggt ctaacgtgaa aaagataacg aaacaactca 1755721 cattatcgtt aaaaaatccg tttatttatc accatgtggt ttacggacaa aatgtcctgc 1755781 cgggattggc ttatatcgat ataatctacc agatattcag agaacacggt ttctcctgct 1755841 cagagcttca gctgcggaat ttatccatct atcagccatt gacggcggaa caggatgcag 1755901 taattgtttt gaatatccaa tgcgcggaga aaaaagaagg acagtggcaa atcacagcca 1755961 agggaattga aaaacgtgat gggaaagaag cttcagaaga aaagctctat atgaaggctg 1756021 acatgcacgc agactcccca gccatatttg aagaaacact ggatctcagt caaatcaaag 1756081 catctgcaca gaacgttgtt cagcttgatg atgtatatga acaatgcaga cgtcaggaat 1756141 tggtgcacag cgaatatatg aaagcaaaag gctgcatcta tgaagaggaa gacggcgtcc 1756201 ttcttgagct ttctctcggt tcggaggcca tgcttcacgc agaaggcttt atgtttcacc 1756261 cgactctcat agacgggagc ggggtgggtg ccaatcattt gctcacatct ttgcttaaag 1756321 gagaacagag gctgtatttg cctctgttct atgaatcctt ttccgcttct gcacttttgc 1756381 aaacggattg catgacaaga attaagcgct cctccgtccg gcgggaaaaa gagctgattt 1756441 atgtaacact tgaatttttt aatgcgtcgg gagaaaaagt ggctgagttg aaaaacttta 1756501 caagcaaatt ggtgcgagaa gcggagctga ttagcggaaa acatcaagat gcacaggaga 1756561 cacagatgac aagagcggac actgctgagc gtgataaacc tgctgacatg gtatcttctc 1756621 ccgttaattc ctatagtgag gctgaacagt tcgtaagcca attaatcgca gagaaaatca 1756681 ataagccggt agaacaagtt gaaaaacagg tcggttatta ccaaatggga ctgaattcat 1756741 cgggcttgct tgaggtggta gaaacgatca gtgataagat cggtgagagc ctttcgccga 1756801 ctcttctgtt tgagcatacc accatagcgg aactgtcagc gtttcttgcc gaggaatatg 1756861 ctgagcattt tagtgccgct ggttctcttg gccagaatga aagagcacgc gtttccgaca 1756921 gcataaacga ccataagact gttgaaggct ctcgtcctgc acctattgag gcagcaggcg 1756981 atattgcgat tatcggcttg gcgggcaggt atccgaaggc agccaatatt catgaatttt 1757041 ggaacaatct gaaagagggt aaggactgcg ttagtgagat tcctgagtcg cgctgggatt 1757101 ggcagcgact tgaaggaatc acatctcctt cgggtaagga catttccaaa tggggaggat 1757161 ttattgatga tcccgactgc ttcgatcccc aatttttcag aatcacgcca agagaagcgg 1757221 agacaatgga ccctcaagag cggctgtttt tagaaacatg ctgggaaacg attgaagatg 1757281 cgggctatac gccaaagacg ttggccaagc ctaaaggacg aaataaaagg cagcatgtag 1757341 gagtttttgc aggcgtcatg cacaaggatt atacattagt cggagctgaa gaagcatcag 1757401 cagaaaatgt gtttcctctt tcgctcaact atgcgcaaat cgccaaccgt gtttcttact 1757461 tttgtaattt ccacggtccg agtatggctg tcgatacggt atgttcatcc tctttgaccg 1757521 cagtgcactt ggcgttggaa agcatacgtc acggtgagtg cgatgttgcg ttagcaggcg 1757581 gagtgaacct gtctttgcac ccgaataaat atatgacata cggggtctgg gatatgtttt 1757641 ccactgacgg acactgccgt acgtttggaa aggatggaga cggttatgtg cctgcagagg 1757701 gtataggcgc ggttttatta aagcctttgc gccaggcaga ggaagacgga gatcgcattt 1757761 atgcagttat taaaggaagt gctgtgaatc atgtgggcac tgtaagcggc atttcagtgc 1757821 cgagccctgt ttcccaagct gatctgattg agacatgctt ggagaaaacg ggaatcgatc 1757881 cgcggacgat cagttatgtg gaagcccatg gaaccggcac gtccttagga gatccgatcg 1757941 aaatacaggg attagtgaaa gcgttccgcc aatatacgca ggatcggcag ttctgttcaa 1758001 tcggttctgt aaagtcaaac attgggcacg ccgaatccgc cgcggggatc agcggtttaa 1758061 gcaaggttgc tcttcagctt caccatcaaa aacttgtgcc ttctttgcat tcggaagaac 1758121 tgaatccgta cgttgatttt gaaaagtctc cattttatgt acagcatgaa acagaaacgt 1758181 ggaagcagcc tgttatcaag gagaatgggg aagacgtccc ttatccgcga cgggcgggga 1758241 tcagttcttt tggcgcaaca ggttcaaacg cacatattat ccttgaggaa catattcctc 1758301 aagcagcgga gcaggacgtt tctttgtcct cagattctga catatccgca gttattccgc 1758361 tttctgcccg taatcaagaa cgtctccgtg tatatgcaaa acgtctcttg gattttcttc 1758421 atgatgggat tcagattaga gatttggcgt atacattgca ggtaggccgt gaaccgatgg 1758481 aagaacgggt ttctttctta gcatccggaa ttcaagaatt gagcgaccaa ttgaaggctt 1758541 ttatagaagg acgaaaagcc attcagcatt gctggaaggg ccgcgtgtca agaggaagcg 1758601 aaccatcgcg tcccgccgaa tcggtacata aattgctgga gcaaagaaaa ctcgatcaga 1758661 ttgcggagca gtgggcgaac ggatctggtg ttgactggaa gctgctttac gagggaagca 1758721 aaccaaagcg gatcagcctg ccgacttacc catttgagag ggtgcgttat tgggtgccga 1758781 aagcggagaa aaagactgat cgttcaaaac aggagcggca catcctgcat cctcttctgc 1758841 atcaaaatgt gtccgacata tcgggtgtcc gcttccgttc agcgtttaca ggacgtgaat 1758901 ttttcttgaa ggatcatgtc ataaagggcg aacacgtttt acctggcgca gctttattgg 1758961 agatggttcg ggcagctgtg gaaagggcag ctgcggatca gttcccgaca ggattccggc 1759021 tccggaatat cgtctgggtc cggccgttcg ccgtcacgga acagcagaaa gatatagatg 1759081 tacgtctata tcctgaggaa aatggtgaga ttacatttga aatctgccgg gaccctgaaa 1759141 gcgcagagga gtcgccgatt gtatatgggc aagggagtgc agtgctttgt gaggctggtg 1759201 aaaatccggt tatcaacatt gaagaattga aggcaagcta taatggccgg acgctgtcac 1759261 cttttgattg ctacgaggct tatacagaaa tgggtattca ttatggtgac agccacagag 1759321 cgatcgacag cctatatgcc ggcgaaaacg gagttctagt gaaattgacg atgcctcctg 1759381 taatctctga tacagaagac cattatattc tgcatccgag catgatagat tcggcatttc 1759441 aagcatctat cggtttgagg ctgggaggag ctacgagttt agaagacaga aaggcaatgc 1759501 tgccttttgc catacaggat gtccgaatct tcaaaggctg cgaggcatct atgtgggcgc 1759561 ggatcacata tagcgagggc agtacagctg gggatcgtat gcagaagctt gatatcgatt 1759621 tatgcaatga agagggccag gtttgcgtgc gattgacgag ctattctgca agagtgttag 1759681 aaacagatca agaaggtcct tctgaagcga atgacacgct attgttcgaa catatttggg 1759741 aagaacgtgc tgcagagagg caagagctca tagagtacga cacgtataaa gtcgttgtct 1759801 gtgatgttgg agaacaaatg gaaagcctcc aaaatcatct tgactgtaca gttctgcagc 1759861 atgatacaga gacaattgat gaacggtttg aaggttatgc catacagtta tttgaagaaa 1759921 tcaaacagct aatgcactca aaaacaggag gacatacatt cattcaagtg gcggtgcctg 1759981 cgttggacga gcctcagcta ttaagcggct taactggatt gctcaaaacg gctgaactgg 1760041 aaaatccaaa actgacagga cagttgatcg aaatagaaac cgggatgtca gctggtgagc 1760101 tattcgaaat attggaggaa aacagacgct atccgcgtga cacgcatatc cgccactggc 1760161 aagggaagcg atttgtaagc aagtggaaag aagtgtctgg tgagcaccta agtgctgaca 1760221 tgccatggaa ggataaaggc gtgtatctga tcacaggcgg tgcgggcggt ctgggattca 1760281 tctttgcaac tgaaatcgca aaccaaacga atgatgcggt tgtgatcctg acaggacgct 1760341 ctccgcttga tgaaaggaag aagaagaagc ttaaagcctt acagaaactt ggcatccaag 1760401 cgatttacag acaagctgat ctggctgaca aacaaacggt tgatgcctta ttaaaagaaa 1760461 cccaaaacgt ttacggagac ttagatggca tcattcatag cgccggttta ataaaagata 1760521 atttcattat gaagaaaaag aaagaagagg ttcaaaccgt tcttgctcca aaggtagcag 1760581 gactgattca ccttgacgaa gcaacgaaag atattccgct cgatttcttt atcctttttt 1760641 cctcaggtgc cggagcagta ggaagcgcgg gacaggctga ttacgcaatg gccaatgcat 1760701 ttatgaatgc attcagcgaa tatcgaaatg gccaagcaga gctgcataag cgttacggaa 1760761 aaactctttc agtgtgctgg ccgctgtgga aagacggggg catgcaaatt gatgcggaaa 1760821 ctgcaaggat gctgaaaaga gaaacaggca tggtggccat ggaaacagat cgtgggattc 1760881 aggcgctata tcatggctgg acgtcaggaa agccgcaagt gttagttgct tccggtgtta 1760941 ctgatcggat tcgtgcattt ttacatgaaa cgggacatgg caaaggccaa tctcacaata 1761001 tcaaaaaaag cagtctcaat caggaggcag aaaaagcaga catgatcggg gaaattgatg 1761061 aagagatact aagagaaaaa gcggagaact attttaaaca ggtgctttct tcggtgatta 1761121 agctgccagc tggccagatt gatgctgaag ctcctctcga ggattacggg atcgattcta 1761181 tcatgatcat gcatgtaacg ggtcaattag aaaaagtatt cggatctttg tccaagacgc 1761241 tgttctttga ataccaggat attcggtcat taacccggta ttttattgat tcccgcagag 1761301 aaaaactgct ggacatcttg ggatttgaaa cgggaaaacc ttctgttgaa agaaaatcag 1761361 aacctgaaaa acaagaaatc ccagttatcc caagaaagtc tggatttctt cctttgcaag 1761421 ataaagagca gaagcaggta agagagaagg aaacggaaga aattgcgatc atcggtatct 1761481 caggtcgcta tccgcaggca gacaacattg atgaattatg ggaaaaactg agggacgggc 1761541 gagactgtat tacggaaatt cctgcagacc gctgggatca cagtctttat tatgacgaag 1761601 ataaagacaa gcctggaaaa acctacagca agtggggcgg cttcatgaag gatgtagaca 1761661 agtttgaccc gcagtttttc catatttcgc cgcgtgaggc aaaattaatg gacccgcaag 1761721 agcgtttatt tttgcagtgc gtgtatgaaa cgatggaaga cgcaggctat acaagagagc 1761781 acctcggccg taagcgtgat gctgagcttg gcggaagcgt cggtgtttac gtcggtgtca 1761841 tgtacgaaga atatcagctg tacggggcac aagagcaggt gcggggaagg tctctggctt 1761901 taacgggaaa tccatcatcc atcgcgaacc gggtatctta ttattttgat tttcacggac 1761961 cgagtattgc tttagacacc atgtgttctt cttctttaac ggctatccac ttggcctgcc 1762021 aaagcctgca gcgcggagaa tgtgaggcgg cattcgcggg cggcgtgaat gtgtcaatcc 1762081 atccaaataa atatttgatg ctcgggcaga acaaatttat gtccagcaaa ggccgatgtg 1762141 aaagcttcgg acagggcgga gacggctatg tgccggggga aggcgttgga gcagtgcttt 1762201 tgaagccatt gtctaaagca gttgaagatg gtgatcacat ttatggaatc attaagggga 1762261 cagccatcaa ccacggggga aaaacaaacg ggtactcagt gcccaatccg aatgcccaag 1762321 cagatgtcat caaaaaggcg tttgtggaag cgaaggttga tccgcggaca gtcagttaca 1762381 tcgaagccca cggcacggga acctctctcg gtgatcctat tgaaatcaca gggctgtcca 1762441 aagtgtttac gcaagaaacc gatgacaaac aattttgtgc aatagggtca gccaaatcaa 1762501 atatcgggca ctgtgagagt gcggcaggta ttgcaggagt aacgaaggta ttgctccaaa 1762561 tgaaatacag gcagcttgcg ccttccctgc attcaaacgt gctgaacccg aatattgatt 1762621 tccttaactc gccgtttaaa gtacagcaag agctagaaga gtggaagagg ccgatcatca 1762681 gtgtcaatgg caaagacatc gaattaccga gaatcgcagg agtctcttca tttggtgccg 1762741 ggggtgtgaa cgcccatatt ttaatagaag agtatgctcc ggaacctgtg gaggaacgtt 1762801 taccagcgag gaaacagccg gctgtcattg tgctctcagc aaaaaatgag gaaagacttc 1762861 agaaacgcgc ggagcgattg ctgcatgcca ttcgtgaaca aacatatgtt gaagcagatt 1762921 tacaccgaat tgcctatacg ctgcaagtcg gccgggaagc gatgaaagaa cggctggcgt 1762981 tcgttgcgga aacgatgcaa gagcttgaag aaaagctgta tgaatgtatc tccggaacag 1763041 aaaatcgtga atatgtctat cgcggacaag taaagagcaa caaagaagcc attgctgctt 1763101 ttgctgctga tgaggatatg tcaaaaacaa ttgaggcatg gctgcaaaaa ggaaaatatg 1763161 cgaaggtttt agacctgtgg gtaagaggtt tgcgaatcga ctggagcacg ctatatcagg 1763221 atcaaaaacc gcggcgcatc agtttacctg cctatccttt cgcaagagat cgctattgga 1763281 tagacgtaaa tgcaaaggct gaggaaaaaa gaacggagga gccattcgct ccagtacagc 1763341 ccgttattcc gaagccgtct gtagacagag aagccagtgg caagcctgcc aatattacgt 1763401 tacagccttt aatgaccaat caggatcgtt tagagcgtgt tccatcagat acagaaacag 1763461 agacgatcac ggcggaagcc ttgtgcgatg aactgacagc gggcttagcg gaagtgctgt 1763521 acatggacca aaacgagatt gatccagacg aagcattcat agatatcggt atggactcga 1763581 ttaccgggct cgaatggata aaagcaataa ataaacagta tggcacatca ctaaatgtca 1763641 caaaggtata tgattatccg acaacacgtg atttcgctgt ttacttagca cacgagttaa 1763701 gcacacaagc tggggagaaa aaacaaacgg agacgtacac gccgatcaga caaaaaacag 1763761 tggtacctgc tgctaaaccg gctaatatat ctctgcagcc gttagaacat catcagccag 1763821 tgcaagagga agctgaagaa acgattcaat atgcagcggc agaaatatct gcatcaagac 1763881 aatatactgt agcaattgaa acgctgcatg aaaacttgag ggaaagcata gcagacgtgt 1763941 tatacatgga gccatacgag gtggatattg acgaagcgtt catagatatc ggaatggact 1764001 cgattaccgg actcgaatgg ataaaagcgg tgaacaagca atacggaacg tcttttacgg 1764061 taaccagagt atatgattat ccaacgatac gtgattttgc cgaaatgcta aagtccgagc 1764121 ttggaactca tcttgataga aagatagagc atactgactc tttcgaagca gcccagcaaa 1764181 agccagcagc atcatctcat ccaaagccgg cagaacggcc actacagcct gttcaacatc 1764241 caataaagaa agaacatgag aagaaaacgg ttcctgttct tcaagaccgc ccggaggatg 1764301 cgatagcgat tgtcgggatg tcgggaagat acccgggcgc tcgtaatgta agagagtact 1764361 gggataacct ggttcatgcg agaaatgcca ttcgggacat tccaacatca cggtgggatg 1764421 ttgacaaata ctatgatcct gtcctcaaca aaaaagggaa agtctattgc aaatcaatgg 1764481 ggatgcttga tgatattgaa cattttgatc cgttgttttt taatattccg ccgtcagaag 1764541 ctgaactgat ggacccgcag catcgaatct ttttgcagga aggctataaa gcctttgagg 1764601 acgctgggta caacgcccga actttaaatg agaaaaaatg cggtgtatat ctcggcatta 1764661 tgagcaatga atacggggtc atgctgaatc ggcagtcaag agcaaatgcc accggaaaca 1764721 gctttgcgat cgcagcggcg cgtattccgt attttctaaa tttaaaaggg ccagcgattc 1764781 ctattgatac cgcatgttca tcttcattgg tcggcactca tttagcgcgc caggcactta 1764841 taaacaaaga aattgatatg gcgctggtcg gcggggtcag cttatacctg acgccggaat 1764901 cttacatgag tatgtgtgag gccggcatgc tttcacctga tggacaatgt aaagcatttg 1764961 acaatggcgc gaatggtttt gtgcccggcg agggtgcggg tgcgctggta ttgaaaaggc 1765021 tgaaagatgc ggaagcggac cgtgaccata tttatggcat catcattggc tcgggtatta 1765081 atcaggacgg gaaaacaaac ggaatcacgg caccgagtgc gaaaagccaa atggatctgg 1765141 aaagagacat atatgaaaca tacggcatac atcctgagag tatcagttat gtcgagatgc 1765201 acggcacagg aacaaaacaa ggcgatccaa ttgaattaga agctctgtcc accgtatttc 1765261 aagaaaaaac agacaaaaag cagttttgcg caatcggttc cgtcaaaagc aatattggcc 1765321 atacatccgc ggcggcagga gtagccgggg ttcaaaaagt gttattgtgc atgaatcata 1765381 aaacacttgt gccgacattg aacttcacga caccgaatga gcattttgaa tttgagcatt 1765441 ctcctttata cgtaaatacg gagcttaagc cttgggaaac ggctgatgga aaaccgcgga 1765501 gagcatgtgt gagctccttc ggatatagcg gaacgaatgc ccatattgtg atagaggaat 1765561 atcagcctga aaagaggaac gatcgattaa caaagcagca ccgctcagca ttatttgtac 1765621 tctcagcgaa aaaagagaag caattgaagg cctatgcgga agcaatgaaa gatttcgtaa 1765681 cttccaatga agatatcgat ctggaggata tggcatacac acttcagacg ggccgggaag 1765741 caatggatta tcgcatggcg tttttggcgg attcgagaga aatgctgatc aaagctttag 1765801 atgattattt ggctgaaatg ccgaacggca gcatatttgc tgctcacgtg aaaacgaaga 1765861 agagcgaaat caagctgttt gaaacggatc atgatgccaa agcattgctg caaacatgga 1765921 tagagaaaaa aaggctggag aaagtagcag agctatgggt gaaagggctg cagatagatt 1765981 ggaacaagct ttatggggaa tacacgcctc gccgaatcag cctgcctgct tatccgttcg 1766041 cggaagagta ttactggctg ccaactcaag aaggcgaacc cgaaaccatt gctacagcaa 1766101 tgcctcaatt cgaactgatg ccaaagcgct gctttctgcg taaacagtgg cagccttgtc 1766161 cgattgaacc ggcagaaatg acgaatcaaa ccgtcgccat tttggcaaat gaggagacaa 1766221 tggcattagc ggaagagctt tcggcgtatt tctcgacata ccgtatattt gacagccaag 1766281 agctggatcg ggtatctgct gctgactatg aacacgttgc tggagcaatc gatctgatcg 1766341 ggtgcggaac gagccatgag cattctatgg gctggataaa ctggctccaa aagctgatcg 1766401 agcaaggacg tgcaagcaag catcatttga cggtcttggg tgtaacaaag gggctggagg 1766461 cctacgcaaa tgagggtgtt cttttgtctg gtgcttcacg ggccggttta taccgcatgc 1766521 ttcaaagtga gtacagccat cttacttcaa gacatgcaga tatggaatgc gaagcctctc 1766581 atgaggagct ggccagactg attgcagttg aatattatgc caagagcaca gaatcagaag 1766641 tctgttatcg aaacggacag cgatatcgcg catatttgac agagcagcca gcagaagccg 1766701 ctctaagtca taagcaagta tcgttttcaa cagacaaagt cctgcttatt acaggcggga 1766761 caagaggtct cggcttgctg tgtgcgcggc attttgtgaa aacatacggc gttaagcggc 1766821 tggtccttat cggccgtgaa gagcttccgc cgcgtgacca gtggaattcg gtaaaaattt 1766881 cctcgcttgc cgagaaaata aaagccgttc aagagctaga agacatgggt gcgcaagttc 1766941 aggtgctgtc tctggatctc acagacaggg ttgctgtcga acagagcctg aagacaatac 1767001 acgaaacaat gggggcgatt ggcggagtca tccattgtgc cgggatggtg aacaaacaaa 1767061 acccggcttt tatcagaaaa tcactagaag agatcggaca ggtgcttgaa ccgaaagtcg 1767121 aaggtctgca aacgttgttt gacctgcttc aagatgaacc attggcgttt ttcaccttgt 1767181 tttcatcagt atcagcggcc atccctgcac tagcagcagg acaagctgat tacgcgatgg 1767241 caaatgcttt tatggattat tttgcggagg ctcatcaaga taaatgtccc attgtaagca 1767301 ttcagtggcc taactggaag gagaccggtt taggcgaggt tcgaagcaaa gctttagaac 1767361 aaactggatt gatcagtttg acaaacgacg agggattaca gctgcttgac cagattctat 1767421 cagacagaca gtatgctgtc gtgctgccgg cagtaccaga tacaaacgtt tggaagccgg 1767481 ataagctgat gcagccgtca ttgcctgtcg aagctctctc gcatcctgag acgaaagagc 1767541 aaaccagcac tcgcaacctg ttccctgaaa cagtcgactg gctcgtaact cttttttcag 1767601 atgaactgaa aatagctgca gaagactttg aaacggatga acctttccaa gaatacggaa 1767661 tcgactcgat tatattggcc cagctggtac agcagatgaa ccaacaatta aatggagata 1767721 ttgatccgtc aatcttgttt gaatacccga caatagaatc ctttgcacac tggctcattt 1767781 cgaaatatga catatcagct gttttacagc catctgttcc tgagaaacag acacctctca 1767841 agccgcaatc agcaatgaaa cagaagctgg tgccagaaca gcggccgcaa cagataagcc 1767901 atgaaaaaac ggcacttctt gctgaggaca tcgctatcat cggtcttagt tgcaggttcc 1767961 cgggagcaga aaccctagag gaatactggg atttaatacg tgatggacgg tctgcgattg 1768021 cgcctgttcc gcctgaacga ttcgggaact ccagctcgaa ttacgcgggc ctcattgatg 1768081 aaatgaaccg atttgatcat gatttcttca tgatgtccga aagcgatgtc agagcgatgg 1768141 accctcaagc tttggctgta ttggaggaaa gcttgaagct atggtatcac gcgggttata 1768201 cagagaaaga agtgaaaggc atgagggctg gtgtttatat aggaggccgc agccagcaca 1768261 agcctgatcc ggccagtctt tcaaaagcaa aaaatccgat agtcgctggt ggacaaaact 1768321 atttagcggc taacatctca caattttttg acttgaaggg accgagtatt gtcctggata 1768381 ccgcttgttc ctctgcactg gtggggctga atatggccat tcaggctctg cgaagcggag 1768441 atattgaggc agcggttgta ggcggcgtca gtttgcttga tgctgatgcg catcgaatgt 1768501 ttcatgagcg cggactttta tgtgacaaac cgtcattcca tatttttgat aagcgggcag 1768561 acggtgtcat tttaggagaa ggcgtgggca tggttctcgt caaaaccgtc aaccaagcgg 1768621 ttgaagacgg agattccata tatgcagtca ttaaagccgc tgcgattaat aatgacggaa 1768681 gaacggcagg cccatcatct ccgaatctcg aggcacaaaa ggacgtcatg ctgtcagcgc 1768741 ttgaaaaaag cggcaaaaag actgaagaga tcagctatct cgaagcgaac ggatcggggt 1768801 cggcagtaac agatttactt gaattaaagg caatccagtc catttaccgt tctgaatcaa 1768861 aggctccgtt agggctggga tcggtgaaac ctaacatcgg ccatccatta tgtgcagagg 1768921 gaattgcgag cctgattaaa gtagctttaa tgctgaagca tagacaattg gttccgttcc 1768981 tgtcaggtaa tgaaaatatg ccgtattttg atatagaaaa aacagatttg tatttcagca 1769041 gatcgcaagc cgagtggaag gagacaacgc cggctgcggc aattaattgt tttgcagatg 1769101 gcggaacgaa cgcccatctc attatagaag gttggagaga ctcggctgag cgtccaatta 1769161 gaagaaaacc tctgcctttg ccggaattaa ataggcagcc cgttttaatc aaaccatcag 1769221 ctcaaaacgt gcagaaaaaa gtgcattcag acacaggggc ttctaaagat atgttttgga 1769281 aaactttcaa ataagagagg agtgggaaaa tgataactga acaactgcac atttcattaa 1769341 ataatccaat catgtccaac cacaaggtat atggacaagc gttattaccc ggccttgctt 1769401 atatagattt aatctaccaa gtattccagg aacatggtta tgcataccaa gagcttgaat 1769461 taaaaaacct aaccattttt taccctttga tcgcagatga gtcatatgac attgccctga 1769521 ccattcacgt gtctgaaaga aaggaaggga catggtccat catcatcgac ggacaaaaac 1769581 agcatggaga atcactatct gacaagagac aatatgtgac tgctgacatg catcgtaaag 1769641 agcaaaccgc ttttgccgaa tcaatagacc ttaatcagtg gaaaagtaca gctgacagga 1769701 ttctgaattt agatgaaatc tatgaacaat gccgatctca agagttagtg cataccggca 1769761 tgatgaaggc ggaaggacag atttatgaag ccaaagaggg ggctgtaatt gatttagcag 1769821 tcggacagga agcattgcgt cattctgatg cttttctgtt tcatccgacg cttattgacg 1769881 gcagcggcat aggttcaagc tgcctgatct cagatcaaac gatgtacctg ccattgtatt 1769941 atgaatcgtt ttctgcttca gaacgattgc aaaaaggatg tacagcacgg atcctctcct 1770001 catctgtgcg ccaaaagaaa gaactcactt atatgacgat tgaatatttt aattcagcag 1770061 gacaaaaagt ggccgagctg aaacaatttg caggcaagtc tgtacggaat atgtcagcct 1770121 ttcattctgc aaaagaaatt caagaagaaa gagctgctgt ctctcagaac atcagtcggg 1770181 actatcccgc atttgaaatg tatttgcgtc agctgcttgc taagcagctt gaaaggccgg 1770241 cagaacaaat ggatatccac gctgggtact atgagcttgg tctggattct tcgtcattgc 1770301 ttaccgtggt tcaggaaatt ggagataagg ttggggcgga tcttgctccg acactgctgt 1770361 ttgaatttac aacaattgca gaactagctg ctcatcttgc tgatcactat tcaattggag 1770421 aggcggacga tgctgtccgc caatctcctt caccaattga tggtgttacc tcttcaccag 1770481 agatcgggga ggacatagcc attatcggaa tggcgggacg ctatcctaag gcgaaaaata 1770541 tacaggaatt ttgggaacag cttaaagcgg gtaccgactg catcacagag attccaaact 1770601 cacgctggga atggaaagaa agcgatggac tggattcacc tgcaggcaag ccgctctcga 1770661 aatggggcgg ctttatcgag gaggctgatt gctttgatcc tcaatttttc agaatctctc 1770721 cgcgtgaagc ggaaatgatg gaccctcagg aacgcttatt tttagagacg tgctgggaag 1770781 ctattgaaga tgcgggttat acaccagaga caattgcttc accgcaggga gaaaataaaa 1770841 gacagcatgt cggtgtgttt gccggcgtta tgcataagga ctattctctt ataggagctg 1770901 aagctctatc agaacacaat ccatttcctt tatcgctgaa ttatgcgcaa atcgccaaca 1770961 gggtctctta ctattgtaat ttccacggcc caagcatggc ggtggacacg gtctgctctt 1771021 cctcattaac tgcggttcat ctggcaatag agagcatccg gaatggagaa tgcgaggccg 1771081 cgcttgccgg aggcgtcaat ttgtcactgc atccggctaa atatatcagc tatggcagtg 1771141 tagggatgca ctcaagtgac ggctattgcc atactttcgg caaaggcggg gatggctacg 1771201 tatctggaga aggtgtcggc acagtattgc taaaaccgct gcgaaaagct gaacaggacg 1771261 gtgaccgaat ctatgctgtc atcaaaggca gtgcgataaa tcatgtagga aaagtaagcg 1771321 gaattacagt accgagcccg gtagctcaag ctgatgtaat cgaagcatgt ctagaaaaaa 1771381 caggaattga tccgcgcacc atcagctatg ttgaagccca tggcactggc acctcattgg 1771441 gagatccgat tgaagtacag gggttagtaa aagctttcag ccgcaatacg caggacaagc 1771501 aattctgttc aatcggttct gtgaaatcaa atattggcca tgctgaagct gcagccggca 1771561 ttagcggctt aacgaagact gtcctgcagc tgcatcataa aaccttggtg ccgtcattac 1771621 attcagaaga gctgaatcct tatttgaagc ttgatcaaac cccatttttt gtccagcatg 1771681 aaacaaagga atgggagcag ccatctttta cagaaaacgg ggtggacgtc acatatcccc 1771741 gccgtgccgg tttaagttcg tttggcgctt caggatcaaa tgcgcatctt attttggaag 1771801 aatatattcc ggcagagagc cattcagaga cgattttaac gaaaaatgaa gaaatagtga 1771861 tacctttgtc tgcgagaaac aaagatcgtc tgcaggctta cgctcttaaa cttcttgatt 1771921 ttcttagcga ggacgtcaat cttttagcgt tagcttatac catgcaggca ggacgggttg 1771981 aaatggagga gcgtgcggcc ttcattgtaa aagacataaa agatttaacg gctaaacttc 1772041 gggcgtttgc caatggcgaa gaagagatcg agggctgctg gaccggacga gccaaggaga 1772101 atcaggaggc ggctgggcta gcatcggtaa atgcgctgaa taacaatttg ataagagaca 1772161 gtgaaatgat ggaaatggcg aaagcatggg ttcaaggaaa gcgggtcacc tgggacgacc 1772221 tatacggcga tcgcaagccg cttaagatca gtgttccgac ctatccgttt gcaagggagc 1772281 gctactggat ctcggttcct gaaatgaaaa ccagcactgt gaatcatatc ttacatccgc 1772341 tggtgcaccg caatacatca gactttactg agcagcgctt tagctctgta tttacaggca 1772401 cggaattttt cctgtcagat catgttgtac agggacagaa aattttgccg ggcgttgcct 1772461 atttagaaat ggcaagggaa gcagcggaaa aagctgcagg cgatctggac ggcgaacaaa 1772521 gagtggtgtc gcttaaagac attgtgtggg tgcgtcctat cacgatagaa agtgaaccaa 1772581 aagaaataca tattggcctt tttcctgagg ataacgggga catttccttt gatatttata 1772641 gcagctctga acataaagaa gaagccctga cgatacactg ccaaggtcgc gctgtcattt 1772701 cagatgaagc ggagacttcc attttaaacc tttcatcaat acagacagaa tgcagcctgg 1772761 acacagtgac gtcagaacaa tgctatgcag cgtttcgaaa gattgggctt gactatggcg 1772821 agggctatca agggattgaa aaagtctatg tcggcaaaga tcaattgctt gcaaaaatct 1772881 cgttacccgc ttttctaaaa aacgacaagc agcattttgc gctccacccg agtttgatgg 1772941 attccgcgtt ccatgccaca gtcggtttta tcgttagctc agtcaatgcc gctggacaag 1773001 ctcagacgct gtctcttcca tttgcgttac aggaggttga tattttcagc ccatgtccag 1773061 agaagatatg gtcttatatt cgatacagtt cagacagtaa agcggagaac aaagtcagaa 1773121 agtatgacat tgatttatgt gatgagaacg gacgtgtttg tgtgcgaatg aagggtgcct 1773181 cgatgcgggc acttgatgga gagcagcatt caaagccgca actattaact gattctcagc 1773241 tgaccgggca tacggtgatg atccccgtct gggaaccagt ctctctagaa gcggaggata 1773301 atgcttcgtt tgctggtaaa agagctgttt tatgcggagc tgctgaagct gatcggactt 1773361 tcataaagca tcattatccg caaatttcct ttgtcgatat ccgccctgca gatgacattg 1773421 aggcaatagc ggacaaactg caagcgtacg gaagcattga ccatgtattg tggattgccc 1773481 cgtcacaccg gggaagtata ggtagtgatg gacaagaaga agctgttctt cacttattta 1773541 agcttgtgaa agcatgcctg caattaggct atggcgagaa acaacttgaa tggtctcttg 1773601 tgaccgtcca agcgcagccg gttacgcaac atgaggcagt acaacccgct catgcaagca 1773661 ttcatgggct tgccggcaca atggcaaagg aatatccaca ctggaaaatc cgtcttctcg 1773721 atcttgaaaa aggctgcaca tggccggtaa atcacatgtt tgcgctccca gctgaccgcc 1773781 ttggccatgc ttgggcctat cgtaatcagc aatggcatca gcagcaattg atcccatatc 1773841 ggtcctcact gtcaggcgac acgctatatc ggaaaggcgg agtctatgtg gtcatcggag 1773901 gagccgggta tatcggagag gcgtggagtg agtacatgat ccgccgctac caggcgcaaa 1773961 tcgtttggat tgggcgaagt caacttaatg ctgccatcca gtcaaaaata gaccgacttt 1774021 cggcgcttgg ccctgagcct ttctacattg cagccgatgc agccgataag cattcactgc 1774081 agcaggctta tgaacaagtg aaaaaacgtc atcctcatat tcacgggatt gttcactctg 1774141 cgatggtttt atttgagcaa agcctggaaa aaatgaagcc ggaagaattc accgctggac 1774201 tggcggcgaa gatcgatgtc agtattcgga tggcccaagt gttccgccag gagaatgtag 1774261 attttgtttt attcttctct tcgcttgtag cccatatcaa aaatgtgaag caaagccatt 1774321 atgcctctgg ctgtacattt gcagatgctt ttgctcacca gctttctcag agctgggcat 1774381 gccctgtaaa agtcatgaac tggggatatt gggggaatag tgaagcggct gaggatgaac 1774441 attatgtaca gctcatgaat caaatcggct taggtttaat tgagcccgcg gaggctatga 1774501 aggcgctgga agcactgctt tctgggccag tcagccaaac agctttcatt catacgacaa 1774561 agcctgtagc agtcgaaggc gtgaatcaga atgaattcat cactctttat ccagagcaac 1774621 cttcagcaga tgcagagagc ctgatggagc gtctgccgac tacgggacga tttcaaagag 1774681 tgacacatga agagcttgat gatcttcttt acaggctgtt gttaggacag ctgcaaacag 1774741 ccgagctgtt tgatggttat acattatcgg ttgaacgtct tcaacaatat aagactcgtg 1774801 aattttatgg aaaatggatt cggcaaagca gcgaatttct cttgcagcat ggctatctta 1774861 agaaagttgg agattcattg gtgaggaagg accaagcaga ggatatcgag ctgctttggc 1774921 tagaatggaa cgcgaaaaaa gaaaagtggc ttaaagacag cgagacaaag gcgatggttg 1774981 tattagcaga ggccatgctg caagcattac cggatatttt gacagggaaa gtccctgcaa 1775041 cagatatcat gttcccgcat tcctcgatgg aactggtgga aggcatttat aagcataacc 1775101 aagtggcaga ctattttaat aaagtgcttg ccgatacatt attagcttat ctggatgaac 1775161 gtctgaagca cgaccctgag gcatcgattc gcattatgga aataggcgca ggcacaggcg 1775221 gcacgagtgc cggaatcttt gaaaaactga aaccatatca aaagcacatc aatgaatatt 1775281 gctatacaga tctgtctaaa gcatttttgc tgcatgcaga aaaggaatat ggggcggaaa 1775341 atccgtacct gacatatcag ctttttgatg tggaaaaacc gattgatcag caggaatttg 1775401 aagcgggagg ctatgatgtc gtcattgccg ctaatgtcct tcacgcaaca aaaaatatcc 1775461 gtcaaacact gcggcataca aaagcggtaa tgaaaaacaa cggaatgctg ctgctgaatg 1775521 aaatggcggg aaacagcctg ttccctcaca tcacctttgg tcttttggaa ggctggtggc 1775581 tgtatgaaga tcctgcagtg cggattcccg gctgtccagg cttacatcct gacagctgga 1775641 aagcggcact tgaaagcgaa ggctttgaat ctgtcttttt cccggccgag gcggcacatg 1775701 atctgagtca ccaaatcgtc gcagcctcaa gcaacgggct ggttcgacgt atgatgaaaa 1775761 atgtgatctt gccggagaag gttgtttcac aagcgtctaa tcaggagcca gcctacattc 1775821 ataccataga ttcagaggaa gctggacaat cgaaacatgc tctcctaaga gaaaaaagca 1775881 cagaatatat gaaaaaacta atcggggaaa cgttgaaaat tcctgcagga aagattgagt 1775941 catctgaacc tcttgaaaag tacggtattg attctatcgt tgttgtccag ctgacgaata 1776001 cattgcgtaa agaatttgac catgtaagca gcactttatt tttcgagtac cagaccattg 1776061 acgcattagt ggagcatttc atcaaaacaa aaacagaagc tctgatgaaa ttaacaggtc 1776121 ttgaccgtca agttcaacaa catacaccgg ccgaaagcag aacccaatct tcacagaaac 1776181 ctgatcaggc cgctaaaaga acacggcgct ttcgcaagct tggcttcagc ggggagaaag 1776241 aaacaccgac aaacactctt gcaagccgtg acgttgccgt tatcggcatt tctggacgct 1776301 atcctcaggc ggaaacagca gaagactttt ggaacaacct aaaagaagga agaaattgta 1776361 ttgaggaaat tccgaaagat cgctgggatt ggaaagctta ttacgataaa gaaaaaggaa 1776421 aagaaggatc aatttatacg aaatggggcg gatttatcaa ggatatggac aagtttgacc 1776481 cattattctt tcagatttct ccgcttgagg cagaaagaat ggaccctcag gagcgattat 1776541 ttctgcaaac cgcttatgca agtattgaag acgcgggata cacgcctgac tcgctctgtt 1776601 caagcagaaa aatcggcgtc tttgccggag tcatgaacaa aaattatccg actggctacg 1776661 gctattggtc tatcgccaac agaatatcct atttactgaa tttccaaggc ccgagtcttg 1776721 cagtcgatac agcctgctca tcctccctga cagcgattca tttagcgctg gaaagcatct 1776781 atagcggatc gagtgattgt gccattgccg gcggtgtcaa tttagttgtc gacccggttc 1776841 actatcagaa tttatctgtc atgaatatgc tctctgctag tgatacatgt aaatcattcg 1776901 gcgatgatgc agatggattt gtcgacggtg aaggcgtagg cgccattgtg ttaaagccgc 1776961 tgcagcaagc aatagcggac ggtgaccata tttacggtgt gataaaggca agtgccatta 1777021 atagcggagg aaaaacaaat ggatacacgg ttccaaatcc tcatgcacag gcacaggtga 1777081 ttaaagaagc aattgagcgc gccgacattc ctgcccgaac catcagttat ttagaggcgc 1777141 atggaacagg cactgcatta ggagatccga ttgagatagc ggggttaaca aaagcattcg 1777201 agaaagatac gcaggagaaa cagttttgtg cgatcggctc cagcaaatca aatatcggcc 1777261 attgtgaaag tgcagccgga attgcagggc tgacaaaaat actttttcag tttaaatatg 1777321 gccaaattgc gccatcattg catgctcagc ggttgaatcc gaacatcgag ttcagccata 1777381 cgccatttgt cgttcagcag caacttggtg aatggaaacg cccggtgatt ggcgggcaag 1777441 aggtgcctag gcgcgctggc ttgagcagtt ttggcgccgg agggtccaat gcccatatca 1777501 tcctggaaga atatattcca agaacggggg cgcaaacgcc gaaagaccat cctccagcgc 1777561 tgattgtgct gtcggccaaa aacatggaac gtttgcaaga aaaagcggaa cagctgctta 1777621 cagccatcaa acaaaaaagg tactgcgaaa cagacctgat caggatcgcc tataccttgc 1777681 aaacaggccg tgaagcaatg gaggaacggc tggcctttat agcggaatca ctagaggatc 1777741 ttgagagaaa gctgaacgat tttatcgaaa acaaagcaga cagcctgtat ctggatcgca 1777801 tcgatgataa caaaaaagcg ttagcagtct tatcagcgga tgaggatacg gaaaaaatca 1777861 tagaagcatg gatgagcaaa gggaaataca cgaaactgct ggatctttgg gtgaaaggct 1777921 tgtctttcga ctggggcatg ctgtacggca cccaaacgcc tgtccggatc agtcttccgg 1777981 catatccatt tgcaaaagaa cgttactggg caccaggcgc ggcaaaggcc ccggtgtcta 1778041 tagaacagga tcatgatcag caaacagaag aacctttcaa ggttatgacg tttcaagaag 1778101 tgtggaaaga agagccggcg actctcacat cgaaacgtat caaaacgctc atctgttttc 1778161 tgactgaaag agaaaagcaa aacgcatttg cttcagccct gaaaaacgtt gatcaagaca 1778221 ccaaggtcat ttttatatca cagggcgaag tgtacagcaa acagtctgaa tatagctacc 1778281 agattgtgcg gcaagaaccc gttacttttg aaaaggcctt ccagagcatt aaagaagaac 1778341 ttggagagcc agatgcaatc ctctatatgt ggcctatgga agacaagcgc tgtataaagg 1778401 accattcctg tattgtttac ctattacaag gtatgtccgc agcaaagctt catccttcac 1778461 ggctgctgct ggcaggatgt tttgaagata gtcttgaccg aagttatctg gaatcatgga 1778521 ttggcttcga acgttcactc gggcttgtcc ttccgcacac aaaagtgact ggaatctttc 1778581 agcccgcgga acaaggatcg atggatgatt ggacacgtaa agtctgggca gaattacagg 1778641 cttcaactga acaaacggtt ttgtatcaga atctgaaacg atatgtaaat cacattgaac 1778701 agacaacgat acaaccggac aacagcaaat tgaagtctgg cggtacttac ctgattacag 1778761 gcggtgtagg agggcttggt tatttatttg ccaagcattt ggccaaaaac tatgccgcaa 1778821 acctgatttt gacagggagg tcgcctttta atgatgagaa gcaaaagcaa ataaaagaat 1778881 taaaggatct aggcggcgaa gcgatgtatg cagaagcaga tgtgtctgat cctatcgcaa 1778941 tgggagactg cgtaaaaaga gggaaagacc gattcggtgc catcaacggt gttattcatg 1779001 cagccggaat cgagagcgac tctgctattt ttgacaaaaa gatcgaaagc ttccagcgca 1779061 tcattgaacc gaaaatcaac ggcacgatag cgcttgatga atggcttaaa aatgaagacc 1779121 ttgattttat gtgttatttt tcttcttctt ctgcggtttt aggggatttt ggatgttgtg 1779181 attatgcgat tggcaatagg tttcagatgg cttacgcaca atacagaaat gagctgcata 1779241 acggtaaaac gtttgtcatc aactggcctg tgtggaagga tggcggaatg aagatcggtg 1779301 atgaggaaac aacggatatg tacctgaaat caagcggcca acgcttccta gaagccgagg 1779361 aaggtatccg tatgtttgag cacatcctag ctcagcagga tgctcagcat ctcgtgatag 1779421 ccggtcagcc cagccgtgtc agcagatttt taggaatgac tgaaccagct attccagaac 1779481 cggccactca agcccctcta gcacaagaaa acaaggatga ggtaaaaaca ctaagcattg 1779541 aaaagcgttt agaacacgac ttgaaagagc atattcacac attgcttaag atttcaaagg 1779601 acaagctgaa tttgaacaaa aattgggccg acttcggatt tgattcgatc tatttggcta 1779661 aattctcgaa cgtgttatca aagcatttca acatcgaagt gacaccggct ttatttttcg 1779721 gctattcaac tttacaagaa ttgatcagct ttttcttaac cgatcataaa gagctgattg 1779781 aagcatttta ccgggatgat gcatcagagg cgcaaaagcc ccctgaagct tatgcagtaa 1779841 ttcctgtagc tttagaacca gaagccagta aaaaaagcat tcggcaggtt cacgatgagc 1779901 ctattgccat tatcggcatg agcggcaggt tccctcaagc tgattcggtc catgagctgt 1779961 gggataatct gaaaaacggt aaatcgtgta tctctgacat tccgggcgaa cgccgggact 1780021 gggggagagc taacagagat ccagaaaaag cagtgccaag gtggggtgca tttttgaagg 1780081 acatagaccg gtttgatccg ctgttttttc aaatatcgcc taaagaagcc gaaagcatgg 1780141 acccgcgtca gcgcattttt ctagaggaag catggcacac gtttgaagac gccggctata 1780201 tgggagatcg gataaaagga aaatcctgcg gtgtttatgt aggtgtggaa gaaggggaat 1780261 atgcgcatct aaccggagat acggattaca ttaacggaac acaaaacgcc acattgtctg 1780321 cgagaatcgc atacgcattg gatttaaaag ggcctaatat ggctttgaca gcagcatgtt 1780381 catctggact ggtggcgatt caccaggcat gttcagctct gcgtcagggg gattgtgaaa 1780441 tggctttagc gggcggcgtc agcttgaata tttctcacat gtcttttgag gcgctgacaa 1780501 gggccgaaat gctgtctccg aacggacaat gcaaagtgtt tgaccaggat gccaatggtc 1780561 ttgtgccagg tgaagcggtg gctgctgttc tcttgaaacc attatcaaag gcaattgaag 1780621 ataaagatca tatttatggc tgcatcaagg ccagcggcgt gaattacgat ggcaaaacca 1780681 acggcattac tgcgccaaat ccttttagcc aggcagaatt gatcgaaaac atttatgaaa 1780741 aaaatgaaat caatccgctc gatattcaat atgtgatggc gcacagtacc ggctcgaatc 1780801 ttggtgatcc gcttgaggtc caagcgttaa cgagcgtgtt cagcaaatat acgaagcaga 1780861 agcaattctg tatgatcagc tcaattaaac ctttaatcgg acatacattt gcagcgtcag 1780921 gaacggttgc tttaatcagt atgctgatgg ctatgaaaaa ccagatcatt ccggccactc 1780981 atcactgtga atcggaaaac ccgtatattc cgtttaaaga aagcccattt gtgctttgca 1781041 aagaaaaccg ttcgtggatc aagaaaaatc agaagccgag gatgggaacg atcagcacga 1781101 ctggaatcag cggcaccaat gcacatgcag tcattgaaga atacattccg gatgatcagc 1781161 cgtccacaca gcggcatcaa gggtcaccgc agatctttgt gatttcagcc caaaatgacg 1781221 atcggcttca ggatgctgcc tgccgcatga ttgcgtatct ggagcagaat cataaccttt 1781281 ctttacctga tgtggcatat acgcttcagg ttgggagaaa agccatggaa gcaaggctcg 1781341 cgatcgttgc aaacaatcag gagcaattgg tgcgaaaatt gaaggaatat gtggaagcaa 1781401 tgaagaatgg tggggtatca ggccaacaga gatcccttta tacaggatat acagaaggga 1781461 ttttagaaga acaagatgaa gcagttctgc aagctctcgc aaaagaaaga aatttggaaa 1781521 acatcgcgga atgctgggtg aaaggatatc agattccttg ggaactcctt catgatggcg 1781581 atgacgttcg gatggtttct ttacctggtt atccatttgc aagggaacgg tattggattt 1781641 cgtcaggcac tcagcaatca gaggccgtta aacagcattc acaagatatg aaaacagaga 1781701 ttgacgagcc gaatggcaaa acccatattc aaaagatcat tgttcaattt ttagcacgag 1781761 aattgggcat atctgaggat cgaatcaatt tcaaaagaaa cttcctggat tatgggatgg 1781821 attcaattct tggccgaaaa ttgatgcggc atatcgaaaa aaccacgcag ctgaagatgg 1781881 ccggccggga aatccttgaa tgtcagacag tccaagctct atctgaccat ttggccttaa 1781941 aagcggaaaa acaaaatcat agcgcagcag cacatcacat aaagggcacg tatacagacg 1782001 agcaaatcat tggattgatg caagaggtgg cgctagggaa attggatttt aagagtgtgc 1782061 aaaacatcat agaagggagt aaatcgtatg aatcataaag aaattctcga tgccttcaga 1782121 tcaggagaat taaccatttc tgaggtggaa gaacatctta aaggcatgaa gcggcagttg 1782181 aaaagcccgc tttcagaagg gcaaaaaggg ctgtggatgc ttcaaaaaat gtctcctggg 1782241 atgagtgcat ataacattcc tttatgcttt cgcttcagca aaccaataca tgcagagacg 1782301 ttcaagaaag cccttctgtt tgtacagaga caatatccgg tcttagccag tgtgattcaa 1782361 gaagaaaatg gcattccatt tcaatcggtt cagttatcaa aggatcttta ttttgtggaa 1782421 gaggatatat cagcaatgaa atcagcagat attatgcctt ttctaaaaga aaaagcaaaa 1782481 gaacctttcc agttggaagc tggtccgtta tggcgcacac acctttttca tcggttagaa 1782541 gaatgcattg ttcttataac aattcaccat atcatatttg atggtgtgtc gatgctgaca 1782601 ttgatatcgg cgctattcga agcgtatcaa caattgctga atgggattga acccttgcag 1782661 cagccatcaa cagctgatta ttacgatttt gtcgattggg aaaatcgaat gctgactggc 1782721 agagaagggg aagagcatct cgcttactgg aaagaacagt tgtctgggag tctgccagtt 1782781 cttgatttgc ctgctgaccg tccgcggtct tcagcacgaa aatttaaggg gcaagcttat 1782841 aaaagcttgc tccctcatca cctgagaaat caaattaaat cgtttgcccg caccaatcat 1782901 gtgaatgaat cggttgtgtt tctctccatt tacaaagtgc tgctgcatca ttatacaaaa 1782961 caaaaggata tcattgttgg cgttccgaca atgggtcggc aagaagacag atttgaaacc 1783021 ctaatcggtt attttatcaa tatgatggct gttcggagca agaatatcgg atctcagcca 1783081 ttaacagcat ttattcggga actgcagctg acagtggctg tcggcctgga tcatgcggcg 1783141 tttccgttcc ctgcattggt aagagagctg aatgtagacc gctcggccgc ggattctccg 1783201 gtttttcaaa cagcttttct gtaccaaaac ttttttcagg caacaggctt gcaaaaagtg 1783261 cttgaaccgt atcaaacgct tggcatcgaa tatattgaag acattcggca agagggtgaa 1783321 tttgagctgg cgctcgaaat atatgagcaa gaaaatgaaa cagtgcttca tcttctgtac 1783381 aaccctgatt tgtacgaact gtcctccatt gaaagcatga tggagaacta tatgaagctc 1783441 gcgcagcaca tgatggagga cccgtctttg ccgcttgaag cctactcttt gcaattaaat 1783501 caagaacaaa ctagtttgct ggaacaatgg aatgcgacag ggacaaacat cgcaaatgac 1783561 aagtgtatac atgaggtgtt tgaggaaaaa gcgaaacaaa cccccgatgc ggttgctgtg 1783621 atgtttgaag acagatcact tacatataaa gaagtagatg aaaaaagcac atctgtggca 1783681 gtctaccttc aacatcaggg tgttagacct gaacagcccg ttggcatttg tgcagagcgt 1783741 tcgtttgata tgatcatcgg aattttagga atactgaaag ctggcggagc gtatgtgccg 1783801 ttagatccaa gttttccgca agaacgatta aagtacatgc tcaaagacag tcaggcatcc 1783861 attgtcctca cccaacctaa cgttcatgat aggatcagcg gattaactgg cagccatgta 1783921 aaagcgatca atatcgagtt agcttgccga aacggttata cagaccagca aagcagcggt 1783981 ttaaagcggg aagtaaaacc ggaacacctc gcttatatta tttatacatc gggaagcacc 1784041 ggagagccta aaggggttat ggtagagcat cggagcatta tgaataccct gaattttctt 1784101 gaatctcact atcctgtaac ggctgaggat gcatatttat tgaagacgaa ctatgtgttt 1784161 gatgtatcga tctcagaatt attcggatgg tttattggag atggccgtct agtgattctt 1784221 ccgcctaatg gggagaaatc accgcagctt tgcatggatt atattgaaac atataaagtg 1784281 actcacatta attttgtgcc ggccatgctg catgtttttt tagaaatggc gaaagacaac 1784341 aagcgattca cagaggacgg tccgctgaag tatatgatgg ttgcaggtga agccttccct 1784401 aaagtattag tgaaaaaggc ggtatcgctc tttacaaact gccgtgttga aaatatatac 1784461 ggaccgacgg aagcctccat ttacgctgcg tatttcggat gcggaaaagg agatatcgca 1784521 agtcaccata caccgattgg aaagcctgtt tccaacacga aaatttatat tgtggaccag 1784581 catttgaagc ctgtcccgat cggaaagcca ggtgagcttt gcatcgctgg agccggctta 1784641 gcaagaggct actttaaaaa gccggggctt acggctgaaa aatttattga taatcccttt 1784701 gaatcaggga cgaagctata taaatcgggt gattcagcaa ggtggcttcc tgacggcaac 1784761 atagaatact tgggacggat tgacagccaa gtcaaaatac gcggttttcg cgtcgagctg 1784821 ggcgcaatag aaacaaagct gggtgaattt ccgggcattt tagatcaggc ggtagtggtg 1784881 aagcagcttg agggccatca acagctcgct gcttattata cagaggaaag cggacatgcc 1784941 tctgccaatc caaaagattt gcgccttcat ctaaaatcga gtctgcccga atatatgata 1785001 ccttcacact ttatccgctt agatgagctt ccattatcgc ccagcggaaa agtgaaccgt 1785061 aaagaattag aaaaacgcga gatcgtgttc aacagaagga aaccaaatca cttgcaatta 1785121 acggaaatag aggatcaggt gctgcgcatt tgggaggaaa cgctcaaggt cagcggattt 1785181 gggccggaag acggattttt cgatgcgggc ggcgattcgc ttctggctgt agctgtggct 1785241 gaacgaatca aaaaagaatt cgattgtgag tttcatgtta ctgagctgtt tgagtattcc 1785301 acgatccgtg caatcagtga atacattttg gagatgaaaa actcagatct agccgggaca 1785361 caaaatgaag atgatcatga tgacaaaaaa gatggaaaat acccgaaaca gaagattccc 1785421 ccttattttg acgacagtgt tgcgattgtg gggatatctt gccagttccc gggtgcgaaa 1785481 aatcatcatg acttctggaa ccacatcaaa gaaggcaaag aaagcatacg attcttttct 1785541 gaagaagagc ttcgcgcaaa tggagttccc gaagaattga tacagcatcc tgactatgtg 1785601 cctgtgcaat ctgtgatcga agggaaagac ttattcgatc ccggtttctt tcaaatctcg 1785661 ccaaaagatg ctgagtatat ggaccctcag cttcgcctct tattgctgca ctcctggaaa 1785721 gcgattgaag atgcaggata tgtggctaag gagattccgg caacaagtgt atatatgtct 1785781 gcaagcagca attcatatag aacgttattg ccgaaggaga caacagaagg acatgaatca 1785841 ccggatggct atgtctcttg ggttttagcc caaagcggaa ccattcccac aatgatctca 1785901 cataagctcg gattaaaagg gccaagctat tttgttcatt ctaactgttc ttcatcacta 1785961 gtcggtttat atcaagcata caaaagcctg acatcgggcg aatcacaata tgcgcttgtc 1786021 ggaggcgcaa cattgcacgc acaatcagcg atcggctacg tgcaccaaaa cgggttgaat 1786081 ttttcaagcg acgggcatgt gaaggcgttc gatgcttcgg cggacggaat ggccggaggt 1786141 gaaggcgtag cagtcatcct gctgaaaaaa gctgtggatg ccgtaaaaga cggagaccat 1786201 atttatgcca ttatgcgcgg aataggcatc aataatgatg gggcagagaa ggcaggcttc 1786261 tatgcgccaa gtgtaaaagg ccaaacagaa gtgatacagc atgtattgga tacaaccaag 1786321 atccatcctg aaacggtcag ttatattgaa gcgcacggga cgggaacgaa attaggcgat 1786381 cctattgaaa tgtctgctct aaataaagtg tacaagcaat acaccgacaa aacacaattt 1786441 tgcggaattg gttcagtgaa aacgaatatc ggccatttgg atacagctgc ggggttagcc 1786501 ggatgtatta aagttgcgat gagtttatac cataatgaac ttgcaccgac catcaactgt 1786561 acggagccga atccggatat aaagtttgaa agctctcctt tttatgttgt ccgtgaacga 1786621 aaatcgttag agaaacacgc aggtgtccat cgggcggctc tgagctcatt cggccttggc 1786681 ggaactaacg cccatgcaat atttgagcaa tatgaaaaca tttctgatgc aggtgccgaa 1786741 aacgaaggca atcagcctta catcattcct atatcagcaa aaaatagtga acggctccaa 1786801 gtatacgcga aggaaatgct gtcctatatc agtcaagacg agcaaaggca tttctcttta 1786861 agagatattg catatacctt ccaagtcggc cgtgaagcaa tggataacag gatcgttttt 1786921 atagtgaacg atctggaaga gtggaaacat cagctggaag cttttgtgac tggaaagccg 1786981 ctcgcagaag gctgtattca aggagaaaaa acgagaatga catccgctga acagctgctt 1787041 ggaaatgctg aagcagatga tatggcttca tcgcggatat caaaagaaga attgagaaag 1787101 cttgccgaga tgtgggcaaa tggctttcac gttgaatggc gcaggctcta tccaaatata 1787161 aagccacgcc gcatcagctt gccgacatac ccttttgccg aagaacgata ctggcctgaa 1787221 agcagcaccg gcgctatcac aacaattgaa ccatctcgtt tgcatccttt ggtgcaccat 1787281 aatacatcgg ttctgtcaga gcagcgtttc agctccattt tcacaggaca agagtatttt 1787341 attgccgagc atatcattaa aggcatggcg attttgccgg cggcggtcac gcttgaaatg 1787401 gcaagagccg ctatagaaca aggaattggc ggattggagg atcatgaaac tggaatcagg 1787461 ctgaaaaatg tcgtgtgggt tcgcccggtt gtagcaggaa gtgagccggt tcaggtaaat 1787521 atcggacttt acgatgaaga tggcggacat attgcttatc ggatgtatgg tgatccggaa 1787581 tccgctgatg cagaaccagt tgtatataac caaggtaaag cggaattgat tcagttaaag 1787641 cgagaaaaag cactggatct ttctaagatc aagaaacaat gtgatcaaag caaaatggat 1787701 gctgcctcgt tttatgaagg gatgatcggc gccgattacg gtccaggtta caagagtgta 1787761 gaggccgtat ataaaggcga cggccagctg cttgccaaat tatcactgcc agaatctgtt 1787821 gcacatacgt tgggcgatta tgttcttcat ccaagtgtaa tggacggggc gttacaggcg 1787881 gctgaatatt tgcaaaatgt cgtcagagcg gaactttcag acactgaaga ctttaaggca 1787941 gcactgccat ttgcactgga ggaacttgag gtttttcgtc agtgcgtttc tgacatgtgg 1788001 gtttatgttc aattcaactc gaaaaacaaa ccaggagatt tgatacagaa agtcgatatt 1788061 cacctatgtg atgagcatgg catgatctgt gtgcggctga aaggattttc gacgagagtg 1788121 atggaggcag atatacaaac cgaaccatca aaaatcaacg ctgaaacttt attgcttcag 1788181 cccgtttggc aagaacaaaa ggctgctaac agcttagctg caaaaaaata tgcagagcat 1788241 ctcgtattcc tatgtgaata tgatcatgag acgagaaaac aaattgaagc agccatcgag 1788301 gatgtccatg tatacagcct ggaagcaagg ccttcttcag tagatgggcg tttccattct 1788361 tatacagaac aagtgtttaa aaaggtacaa gagatcattc gtacgaaacc gaaagacggc 1788421 attctcgttc agatcgtgac ctctgccgag ggagaacagc aattgttttc agggttgaca 1788481 ggactgctga aaacagcttg tcaggaaaat gccaaactaa ccggccaaat gattgaagtc 1788541 agcagtgaag aaagtggaga aagcattgct ggcaaactgt tagaaaatca aatgagcagc 1788601 gattcatatg tcaaatatca aaacgggaca cggtatattg ctgattggcg tgaaatcaaa 1788661 caggcaaaag gagacggcag caaaccgtgg aaagacaatg gcgtttatct catttcagga 1788721 ggtgccggcg gactaggtca tatttttgca aaggaaattg cggaacaaac gaaaaatgcg 1788781 acagtcattc tggcgggccg ctcacctctt agcgaaagca aaagcaaaaa gctgaaagag 1788841 cttcatagca agggggctga catcacctac cggcaaacag atgttaccaa taaaattgaa 1788901 gtctatcagc tcattgacga cattcaaaaa agatatggcc gtctgaacgg tattcttcat 1788961 agtgccggaa tcatcaagga cagctacctg gttaataaac aggcaaaaga tctgcacgat 1789021 gtactggcgc ctaaagtaaa agggcttgtt tatctagacg aagcgagtaa ggatttgcct 1789081 ttagacttct ttattctctt ttcatctctt tcaggaagtt tagggagcat tggtcagtct 1789141 gactatgcgg cagccaatgt atttatggat atgtatgcag gctatcgaaa taggcttgcc 1789201 gacctcagcc agcggcatgg gcagacgctt tctgtaaact ggcctttatg gagagatgga 1789261 ggcatgcagg tcgatcaaga aactgagaaa aggcttgtgc aacttgccgg tattgttcct 1789321 atgagggcgg aaaaaggaat tcaggcatta tatcaagcac ttcattcaga ggcaaaccaa 1789381 gtaatggtga tcgaaggcga tgtgcagaaa ataaaacaaa acatgctggc caaaaacgcc 1789441 tcagcaccta tggaaaagaa ggaagcagaa cacatgactg aacaaataaa tagcattgat 1789501 gcagacagtt tgctggataa agtaaaggcg atgttaaagc gagagatcgc caagctgtta 1789561 aaggtcaagc ttgaaacgat tgacgatcat gcagagatga cggtgtatgg ttttgattct 1789621 atctccatga ctgaattcac caaccatatc aatcgcgcct atcagttaga gctgacgcca 1789681 accgtatttt ttgaccaccc gacgattcat gcgtttggca agcatttgtc agaagaatat 1789741 caatcggtat ttgcgaagac atttgctgtg cgcgctgtat cggctcagct tcagcctgct 1789801 gcgaaacagg aacaagccgt gcgtgccaaa gctaaaagac gcagaaagca gcaagtcatg 1789861 ctgccaaacg ccatacagag tgatgctggg cctgagccaa ttgccattgt gggcataagc 1789921 gggattttcc ctatggcgaa agacgttgag gcgtactgga acatcttaaa agagggcaaa 1789981 gactgcatga cggaaatccc gaaagatcgc tgggattggc gtgaatatga aggtgatccg 1790041 gcgaaggaag tcaataaaac gaacgtgaaa tggggcggtt ttattgacgg tattgcagat 1790101 tttgatccat tattctttgg catttccccg cgtgaagctg aacaaatgga acctcagcag 1790161 cgcttactgc tgacttacgc ctggaaagcg atcgaagatg caggatattc ggcgaaaagg 1790221 ttgtcaggca caaaaaccgg cgtcttcatc ggaacgggaa atacaggata cagctctctt 1790281 ctatctaaag cgaactcggc aatagaagga tcagcggcag ccaatacgag cccatcggtc 1790341 ggtccgaacc gggtcagtta tttccttaat ctgcatgggc cgagcgaacc ggttgataca 1790401 gcgtgctcaa gttcactagt ggcgatccac catgccatct cttcaattga ggaaggcact 1790461 tgtgacatgg cattagccgg cggtgtaaat acgattatcc ttcctgaggt gtatatcagc 1790521 tttgataagg cgggagcact gagcaaagaa ggaaaatgca agacgttttc aaatcaagcc 1790581 gatggttttg cacatgggga aggtgccggc atactgttcc tgaaaaaatt aaaagcggct 1790641 gaagaagcgg gagaccatat ttacggagtc ataaaaggca gtgcaatcaa tcacggcggc 1790701 cgtgcagcct ctttaacgac tcccaatccg aaggcgcagg cagatgttat tcagtcggca 1790761 tatcaaaaag cgggaatcga cccgaaaacc gtgacctaca ttgaagccca cggaaccgga 1790821 acggagcttg gagacccggt tgaaattaac ggtttgaaat cagcttttaa agcattgggt 1790881 gtaaatgaag gagacacatc agccaatcct tactgcggat tagggtctgt aaagacaaac 1790941 atcggccact tatcgctggc agccggtgca gcaggagtta ttaaaatatt attgcagctt 1791001 aagcataaaa ccttagtgaa aagtctgcat tgcgaaaacg tgaatccata cattcagctg 1791061 aaaaacagtc cgttctatat cgtacgggaa acggaagaat ggaaagcgct gaaaaatgaa 1791121 cagggagaag agcttcctcg acgggcaggt gtcagttcat ttggaatcgg cggagtaaac 1791181 gcccacgtga ttatcgagga atatattccg gaagcatccg atgagaatat accatccatc 1791241 gcgccggaac atccgggtat cttcgtttta tcggctaaaa atgaagcgcg gctaaaagaa 1791301 catgcacagc agctggcaga tgcgcttgat aagcaaacat atagtgacgt aaatctcgcc 1791361 cgaatcgctt atacactgca agccggacgg gatgcgatgg aagaacgtct cgggattatt 1791421 tccggttcca ttgaggattt acagaaaaag ttaaaagact ttgcagcgga gaaaagcggt 1791481 gtggaggatg tatttaaagg caggattgat aaaggcacac tccaaatgct gacagaggac 1791541 gaagagattc aagaagccgt cgagaaatgg atggaacggg gaaagtatgc aaaattgctt 1791601 gaattatggg taaaagggct tgatgtagac tggacgaaat tgtatggcga gaatctgcca 1791661 aagcgcatca gcttgccgac gtatcctttc gcaaaagacc gttattggat ctctgatcat 1791721 attgaaaaaa gcggcagcat tgatgcaaat caagcagcct cccgccttgg cggagccgtg 1791781 ctgcatccat taatgcatca aaacacatcc aatctctcgg aacaaaggtt tagctctatt 1791841 tatacgggag aagagttttt ccttgctgat catgttgtga aaggccaacg gattttgccg 1791901 ggagtggctc atcttgaatt ggcgcgggca gctgttgagc aggccgcaga ggtacaaggt 1791961 gtaccgcgca tcatgaagct aaagaatgcg gtgtgggtgc ggcctattgt tgtagaggat 1792021 cagccgcagc aagtacacat taggctttta ccgggagaaa atggtgagat ctcttatgaa 1792081 atctatggtc attcagacgt tactggcgaa cagtcaatcg tctacagtca aggcagcgcg 1792141 gtattgaatc ctgctgaaaa tttgccggcg gttgatttgc aatctctgcg ggagcagtgt 1792201 caggaaagtc atttcagcgt aaacgaagta tacgacacct atcgaatgat tggatttgaa 1792261 tatggtcctg cttatcgcgg agtgaaaaaa atctatacag ctgaacaatt tgttttggca 1792321 aaattgtcat tgcatccgtc agctgcagat acgctcagcc aatacaaaat gcaccctggg 1792381 ctgatggatt ctgctttgca ggcgtcaagc attttgacag gagccgggga taaccagctg 1792441 acactgcctt ttgcggtcca ggagcttgaa gtcttcggag catgttcgtc agaaatgtgg 1792501 gtatacgcaa gatacagcca aggcagcaag gcaactgata aggtgcaaaa gcgcgatatg 1792561 gatattttag atgagagcgg caatgtttgc gtacggatga aaggattatc tttcagagca 1792621 gcagaaggcg gctctggatc ggcggaatct gatcaaacgc tggcaaccct gatgtttgaa 1792681 gaaaaatggg tgcccaagga ttttaaaaaa gaaagtcctg agcctcatta cgaacggcac 1792741 attgtcatgc tttgcgacat gaatggcctc tcaaaagatc gcattgaatc aagaatgaca 1792801 ggagcggaat gcatcgtttt ggagtcattc cgcgaaggac ttgcagagag gttccaagat 1792861 tatgccgaac aagcgcttga gacggtccag ggtcttctca aaagcagacc tcagggcaat 1792921 gttctgatcc agctgcttac ctctgcacaa agaaagcagt actcattctc agggctatcg 1792981 gcgctcctta aaaccgccgg cctggagaat aaaaaactaa tcggccagac gattgaaatc 1793041 gattcacatg aaaatgttga aagtgtaata gaaaaactga aagagaataa aaggcacaca 1793101 gaagatcagc acatcaaata tgaaaaaggc aaacggtaca tcaatgatct ggatgaaatg 1793161 caaatagatg atcgggaaat aagcatgccg tggagagata aaggtgtata cctcatcacg 1793221 ggcggcgcag gaggacttgg gtttattttt gcaaaagaga ttgctcgcca agccgaacag 1793281 cctgtgctca ttctgacagg cagatccgcg ttgaatgcgg atcagcaggc ggagcttaac 1793341 gaacttcagc aattaggggc tcgcgcagaa tacaggcagg ttgacgtgac acaaacggaa 1793401 gcagcctccg agcttatcac aagcattacg tctgattacg aagacttgaa tggtgtcatt 1793461 cacagcgctg ggctgattaa agataactat cttatgagca aaaccaatga agagctgaca 1793521 caagttctcg ctcctaaggt gaaagggctt gtgaatgtgg atgaggcaac cgagcatctt 1793581 gcgttagatt tctttatcct cttttcttca atatcaagtg ttgccggcag cgcgggacag 1793641 gccgattatg caatggctaa tgcatttatg gacagttatg ctgcttatcg gaatgcgctt 1793701 gtaaccgcca tgtacaggca cggacaaacg ttgtcaatca attggccgct ctggaaagaa 1793761 ggcggcatgc gcgcgaataa agaaattgaa aacatgacgt tgaaaaacac aggtgtgact 1793821 ccaatgcgga ccgagaccgg cattcaagcg ctgtataaag gtttggcatt tggcaaagat 1793881 caagtcatcg tcatggaagg attcaaagac atgatgaggg aaaagctgac tcaaaagccg 1793941 tcttctgatg atgtaccaat gaaaacagtg caagtacggg tgacatctga agcaagaatg 1794001 gatcaaggga atatgtttga ccacattcaa gaagttttaa agcaaacaat ctctcaattg 1794061 ctcaaaatca aacctgaaga gattgacccg gacatggagt ttaatcaata tggatttgat 1794121 tcgattacgt taactgaatt cgcaaataca ctgaatgaga agtgcaagct ggatcttacg 1794181 cctacggtct tctttgagca cgcaactgtt tatgcatttg cagggtatct gtcagaagaa 1794241 tatccaaatg cttttacagc tcaaacgcct gccaaagctg aggtgctgat gcagcctgtc 1794301 gaacagaata taaaaaatat gacgttttcg actgaaaacc gctttgtaaa accttcggta 1794361 acaccaatgc aaaaggaagc tgatcacaag cctgagccta ttgcgattgt ggggatgagc 1794421 ggcgttttcc caaaggcaaa agacgttgag gaatattgga agaacctgtc atcgggcgca 1794481 gattgtatta cagaggttcc aaaagaccgc tgggattggc aggagtatta cggagaccct 1794541 ctgaaagaag cgaataaaac aaacgtcaaa tggggcggtt ttattgatga agttgctgac 1794601 tttgatccat tgttcttcgg catatctccg ctggaggctg agcagatgga gcctcagcag 1794661 cgcctgttaa tgacctatgc gtggaaggcg gtagaagaag cgggacactc agcgagaagc 1794721 ctggcaggaa ccaaaacggg catcttcatc gggacaggaa acacagggta cagttcactt 1794781 ctgtcaaatg tagacatcga aggctcagcg gctgcgaata tgagtccttc tgcaggaccg 1794841 aatagagtca gttatttcct gaacattcat gggccgagtg aaccgatcga cactgcgtgc 1794901 tcaagctctt tggtcgccat tcatcatgcg gtttgcgcca ttgaaaatgg aaactgtgaa 1794961 atggcgattg cgggaggggt caacacggtc gtaactccgc aaggccatat cgcctatgat 1795021 aaagccgggg cgctgagcaa agaaggaaga tgcaaaacat tttctgacaa agccgatgga 1795081 ttcgcagtca gtgaaggtgc cggcattctc tttctgaaaa agctgacagc ggctgaacga 1795141 gacggtgatc atatttacgg tgtcattaaa ggaagtgcgg taaaccacgg tggccgcgca 1795201 aattctctaa cgactcctaa tccgaaagct caggcggatg tcgtaaaaac agcatatgaa 1795261 aaagcgggaa ttgatccaag aaccgtaact tatattgaag cgcatgggac tggaacagag 1795321 ctgggcgatc cagtagaaat caacggctta aaagcggcat ttaaagagct gtatgaaaaa 1795381 acgggggacc cggctgttca tggcagccat tgcggacttg ggtcagcgaa aacaaacatc 1795441 ggtcacttat cactggcggc cggtgtggct ggtgtcatta aagtgttatt gcagctcaag 1795501 cataaaacgc ttgtcaaaag tctgtacagt gaaactgtta atccgtatat cagactggat 1795561 gacagcccgt tttatattgt gcaggaatcg agagagtggc aggcgcttcg ggatgaagcc 1795621 ggccgagagc tgccgcgccg cgcaggtatc agttcgttcg ggataggcgg cgtcaatgcc 1795681 cacgtggtca ttgaggaata tattccgaaa gaaacaaccc atcctgcaac agcaccagcc 1795741 gtgacagcac agcacccggg catctttatt ttgtcggcaa aggatgaaga tcgtctgaaa 1795801 gaccaagccc ggcaattagc agactttatc agcaagcgat ctatcactgc tcgtgacctc 1795861 actgatattg cttatacact ccaagagggg cgtgatgcaa tggaggagag attagggatc 1795921 atcgctgtct cgactgggga cttgctggaa aaactgaacc tctttataga agggggcacc 1795981 aatgcgaagt acatgtacag aggcagagca gaaaaaggta tcgcacaaac attgagatca 1796041 gatgacgaag tacagaaaac gctcaacaat agctgggagc ctcacatata tgaaagactg 1796101 cttgatttat gggtaaaagg catggaaata ggctggagta aactgtatga cggcaaacag 1796161 ccgaaacgca tcagcctccc tacctatcca tttgcgaaag aacgctactg gataacggat 1796221 acgaaagagg aggcagccgc ccatcaaaca gctttaaaaa cagtcgaatc agcagctttg 1796281 catccattga tacatgtcaa cacatctgat ttgtcagagc agcgtttcag ctcggccttt 1796341 acaggtgctg agttcttttt cgccgatcat aaggtgaagg gaaaaccggt tatgccgggc 1796401 gtggcatatc ttgagatggt tcatgctgcc gttacaagag cagtgagaag aaccgaagat 1796461 caacaatctg ttattcacat caaaaatgtt gtgtgggtgc agccgattgt ggcggatggc 1796521 cagcctgttc aagtggatat cagtctaaat ccccagcagg acggcgagat tgcttttaac 1796581 gtctatacag aggctgcaca caatgatcga aagatacatt gtcaaggcag tgcttcaatc 1796641 cgtggggcag gagacattcc agtccaggat atcagcgcgc ttcaagacca atgcagttta 1796701 agcacactct cacacgacca gtgttatgaa ttgtttaagg cgatcggcat tgactacgga 1796761 cctggttttc aagggataga tcggctttac atcggccgca atcaagcctt ggcagagctt 1796821 tctctgcctg ctggtgtaac tcacacactg aatgaattcg ttcttcatcc aagtatggcc 1796881 gactctgctt tacaagcgtc gatcgggcta aagctgaatt ccggtgacga gcagctttct 1796941 ctgccttttg cgctgcaaga gctagaaata ttcagcccgt gtacaaataa aatgtgggtg 1797001 tctgtgacat ctcgtcctaa tgaggacaaa atacagagac tggatattga tttgtgtgat 1797061 gaacaaggcc gagtgtgtgt aagaatcaag gggattacct caaggctgct ggaagaaggc 1797121 atacaaccgc cagacgggcc gacatcacta ggaaactcca aagcaactct taacggagcg 1797181 cttcttatgg cgccgatatg ggatcgagtg cagctggaga agaggagcat ttcgcctgct 1797241 gatgagcgtg ttgtcatcct cggaggggat gacaacagca gaaaagctgt tcaaagggag 1797301 tttccgtttg ccaaggagct gtacattgag ccgaacgcat caattcatag aattacaggc 1797361 cagcttgaag cactcggatc gtttgaccac atcgtgtgga tgtctccttc tcgtgtgaca 1797421 gagtgcgaag tcggcgatga aatgattgaa gcccaagatc aaggcgtcat tcaaatgtat 1797481 aggctcatta aggcaatgct ttctttaggc tatggacaga aggagataag ctggacgatc 1797541 gtgacggtga acacacaata tgttgatcag catgatattg tcgacccggt cgatgccggg 1797601 gtgcacggcc tgatcggttc aatgtcaaaa gaatatccaa attggcagac aaagctgatc 1797661 gatgttaaaa aatacgaaga cctgccgtta tctcaactcc tttccttgcc tgccgatcaa 1797721 gaagggaata cgtgggccta tcgaaacaag atttggcata agcttcgtct aattccagta 1797781 cacaacaatc aaccggtgca cacgaagtat aagcacggag gtgtttatgt tgtcataggc 1797841 ggagctggcg gtattggtga ggcgtggagt gaatatatga tcagaacata tcaggcgcag 1797901 atcgtttgga ttggcagaag gaaaaaggat gcagccattc aaagcaagct ggacagattt 1797961 gcacgtctag ggcgagcccc gtattacatt caagcagatg cggctaaccg agaggaatta 1798021 gaacgcgcgt atgaaacaat gaaacaaaca catcgtgaaa tcaacggcat catccattct 1798081 gcaattgtct tacaagaccg aagcctgatg aatatgagtg aggaatgttt cagaaacgtt 1798141 cttgctgcaa aggttgatgt aagcgtgcga atggctcaag ttttccggca tgaaccactg 1798201 gattttgttt tgtttttctc ttccgtacaa tcgtttgcaa gagcttccgg acaaagcaat 1798261 tacgctgcgg gttgcagttt taaggatgct tttgcacagc ggctttctca agtatggcct 1798321 tgtacagtag ccgtgatgaa ttggagttat tggggaagca ttggtgttgt ttcatcaccg 1798381 gattaccaaa agagaatggc tcaggcaggc ataggctcaa ttgaagcccc tgaagcaatg 1798441 gaagctttgg aattgctgct cgggggaccg ctgaagcagc tagtaatgat gaaaatggca 1798501 aacgaaacga atgatgaagc ggaacagaca gaagaaacga ttgaagtgta cccggaaact 1798561 cacggctccg ccattcaaaa gctgcgaagc tatcacccgg gtgacaacac aaagattcaa 1798621 caactgttat aggaggggaa acgccaatgc tgaacacaga agacattctc tgtaaaatgc 1798681 ttttcgcaca attacagtcc atagggtttt tcacagaaag taaatcccag ccggtattgg 1798741 agaatttcta tggcagatgg tttgaagaaa gccaatcgat tttagaacgg catcaatttc 1798801 tcaagcgaac ggagaacgga catgttccaa cacgctcaat aggcaccatg agcgagctgt 1798861 ggaaagaatg gaatgaacaa aaatttgacc tgcttcaaga caataatatg aaagccatgg 1798921 tgacattggt ggagacagca cttaaagcct tgccggagat tctgaccggc aaggcgtcag 1798981 ccaccgatat cctgtttccg aattcatcta tggatttagt agaaggggtc tataaaaaca 1799041 atcaagtcgc agactatttt aatgatgttc ttgcagatac gttaacagcc tatctgcaag 1799101 aacgtctgaa gcaagagcct gaggcgaaga ttcgaatatt agaaatcgga gccgggaccg 1799161 gcgggacaag cgcggctgtt tttcaaaaat tgaaagcatg gcagacacat ataaaagaat 1799221 attgttatac agatctgtct aaagcttttt taatgcatgc agaaaataag tatggtcctg 1799281 acaatccata tttgacatat aaacgattta atgtcgagga gccggcgtct gaacagcata 1799341 ttgatgcggg aggctacgac gcggtcatcg cggcaaatgt gcttcatgcc acaaaaaata 1799401 tccggcagac attgcgaaat gcaaaagcag ttttgaaaaa aaacgggctg ctccttttaa 1799461 atgaaataag taatcataat atatattcgc atttgacgtt cggcctttta gagggctggt 1799521 ggctgtatga ggatcctgat ctccgcatac cgggctgccc gggcctgtat ccagacactt 1799581 ggaaaatggt gcttgagagt gaaggatttc gctatgtttc ctttatggct gaacaatcgc 1799641 atcaactcgg ccagcagatc attgccgctg aaagtaacgg agtcgtccgt caaaagaaga 1799701 gaacggaggc agaagaagat ccaagccata tacaaatgaa tgctgaaatc gatcattcac 1799761 aggaaagcga ttctctcatc gaacaaacgg cacaatttgt gaagcatacg ctggcaaaat 1799821 caatcaaact atcaccagaa cgtattcacg aagatacgac atttgagaag tatggaattg 1799881 attcgatttt gcaggtgaat ttcattcgtg aattagaaaa agtgacggga gagcttccaa 1799941 aaaccatttt atttgaacat aacaacacaa aagaactcgt cgaatattta gtaaaggggc 1800001 atgaaaataa gcttcggaca gcattgttaa aggaaaaaac gaagcctgca aaaaatgaag 1800061 ctccacttca aacagagcgt acagatccta ataagccatt tacttttcat acacgccgct 1800121 ttgttacaga gcaggaagtc acggaaactc agctagcaaa taccgaacca ctaaaaatag 1800181 aaaagacaag taatttgcaa ggaacacatt ttaatgattc tagtacagaa gatatcgcaa 1800241 taatcggggt aagcgggcgc tatccgatgt ctaacagttt agaagagctt tgggggcatt 1800301 taatcgccgg agacaattgt attacagagg caccggaatc cagatggcgc acatctttat 1800361 tgaaaacatt atcaaaagat ccaaaaaagc cggcaaataa gaaacgctat ggcggatttt 1800421 tacaagatat agaggcattt gaccatcagc tttttgaggt ggagcaaaac cgggtgatgg 1800481 aaatgacacc ggaactccgt ttatgtttag aaaccgtctg ggaaacgttt gaggacggcg 1800541 gctatacgcg aacccggctg gataaattgc gggatgatga cggagtaggt gtttttatag 1800601 ggaatatgta taaccagtat ttttggaata tcccatcttt agagcaggca gtcctcagct 1800661 caaatggggg agactggcac attgcaaatc gcgtttccca cttttttaac ctgaccggac 1800721 cgagtatcgc tgtcagctca gcatgctcta gttcattaaa cgccatacat cttgcgtgtg 1800781 aaagcctgaa attgaaaaac tgctcaatgg cgattgctgg aggtgtcaat ttaacactcg 1800841 atctctctaa atatgattct ttggagcgtg ccaatctgct gggaagcggc aatcaaagca 1800901 aaagttttgg caccggaaac gggcttattc ccggggaagg cgtcggagct gtcctgttaa 1800961 aaccactttc gaaggcgatg gaagatcagg atcatattta cgctgtgatc aaaagcagtt 1801021 ttgctaacca tagcggcgga agacagatgt atacagctcc ggacccgaag cagcaagcaa 1801081 agttaattgt caagtcgatt cagcagtcgg gcattgatcc agagactatc ggctatattg 1801141 aatcggcggc aaatggttcg gcgctgggcg atcctattga agtaattgcc ttaacaaacg 1801201 cgtttcaaca atatacaaac aagaaacagt tttgtgcgat aggctctgtc aaatccaatc 1801261 tggggcattt agaggcggct tccggtattt ctcagctgac aaaagtgctg ctgcagatga 1801321 agaaagggac gctggtgccg acaattaacg cgatgcctgt caatccaaat attaagctgg 1801381 aacacacggc tttctatctt caggaacaaa cagagccatg gcatcgcttg aatgatcctg 1801441 aaactggaaa acaattgccg cgcagaagca tgatcaattc cttcggagcg gggggagcct 1801501 atgccaatct tattatagaa gaatatatgg agacggcccc tgagaaagaa catatcgctc 1801561 cccgccagca ggaattcact gccgtttttt cagccaaaac aaaatggagc ctgcttagct 1801621 atctagaaaa tatgcaattg tttttagaga aggaagcttc tctggatatt gaacccgttg 1801681 tacaggcttt acacaggaga aaccataatt tagagcatag gactgcattt acagtggcat 1801741 cgactcaaga gctgatcgaa aaactaaagg tgttccgaac atcaagagaa agctcactcc 1801801 agcaaggcat ctatacatca ttcgatttac agccatgtgc ggaatcagca tctagggata 1801861 gagaaataaa cgcagcagag caatgggcac aaggggcatt gattgctttt aaagaagctg 1801921 atatagggaa ccgaacaggc tgggttcatc tgcctcacta tgcatttgac cataatacat 1801981 catttcattt cgatgtatcg tctatcaatg agaaatcgtc agatgttgaa gacaatatca 1802041 atcagccggt cattcaagat caattcactt atgatgagcc ttacgttcaa ggacacgtct 1802101 tcaacaatga acgggtgctt gtcggtgcca catatggcag tctggccatt gaagcatttt 1802161 ttaacctgtt ccctgaggaa aacagcggcc gtatcagcaa attaagttat atcagtccaa 1802221 ttgtcatcaa acaaggcgag accattgaac ttcaggcaaa gccgctgcaa aaagatcaag 1802281 tcatagaact gcaaatcatg tatcgcgagc cgtcctctgg tttgtggaag cctgccgcaa 1802341 tcggacaatg cggaatcggt tcttttgagc ccaaaaaagt caatatcgag aacgttaagc 1802401 attcattaac taagcttcat cacatcgatc agatgtataa aaccggaaac ggtcctgaat 1802461 ggggagagtt atttaagaca attactcatc tctacagaga tcacaagtct atactggcaa 1802521 aaattcgcct gccccaaagc gggctggcaa acgggcacca ttacactgta agcccattga 1802581 tgacaaacag cgcgtacttg gctatcctca gtttcttaga gcagtttgac atgacaggcg 1802641 gcttcctgcc gtttggaatc aatgatatcc agtttacaaa gcaaacgata aaaggggatt 1802701 gctggctttt gattacattg gttaagaata caggtgacat gttgctgttt gatgtagatg 1802761 tgatcaatga gtcgtcagaa acagtgctgc actactcggg ctactcgctt aaacagcttc 1802821 gtatttcgaa tcaaagagga aatcaaaata aggccatcaa agccagcaat ctgaaagctc 1802881 gtatcagaag ctatgtaaca gataaactgg cagtaaacat ggccgatccg tcaaaattgt 1802941 caattgcaaa agcgcatatc atggattttg gaattgattc ttctcaattg gttgcactga 1803001 caagggagat ggaagcagag acaaagatcg aattaaatcc gactctgttt tttgaatatc 1803061 cgactattca agagttaatc gacttttttg cggacaaaca tgaagcatct tttgctcagc 1803121 tgtttggtga agctcatcag caggaagaac gcccagctca aatcgaaaac caaatgaaac 1803181 agattccggc atacgagacg aacacggata aaacaatcga acacgcggca gacggcatag 1803241 ccattatcgg catgtcggga cagtttccga aagcaaacag cgtaacggaa ttttgggata 1803301 accttgtcca aggaaagaac tgtgtctctg aagtgccgaa agaacgctgg gactggcgca 1803361 aatatgccgc agccgataag gaagggcaat caagccttca atggggcggt tttatagaag 1803421 gaataggtga gtttgatccc ctgttttttg gcatatcgcc taaagaagcg gcgaatatgg 1803481 acccacagga gtttctgctc ttgatacatg catggaaggc gatggaagat gcaggcttaa 1803541 cagggcaggt tttatccagc cgcccgacag gagtatttgt cgcagccggc aatacggata 1803601 cagctgtggt tccttcccta attccaaacc gtatatccta tgcacttgat gtaaaagggc 1803661 caagtgaata ttatgaagct gcctgttcct cagctctagt ggctttgcac agagctatac 1803721 aatccattcg aaacggcgaa tgtgagcaag ccattgtcgg ggctgtgaat ttgctgcttt 1803781 caccaaaagg ctttattggc ttcgactcaa tgggctattt gagtgagaaa gggcaggcca 1803841 aatcctttca agcagatgca aatggctttg tcagaagtga aggagcagga gttctcatca 1803901 ttaaaccatt gcaaaaagcc attgaagatt ctgatcatat ttattcggtt attaaaggtt 1803961 caggtgtatc gcatggcggc aggggaatgt cacttcacgc gccaaatccg gccggcatga 1804021 aggatgcaat gctgaaggct tatcaaggag cgcaaattga tcccaaaacg gtgacctata 1804081 tagaagcgca tgggatcgcc tctccattgg cagacgcgat agaaatagag gcgttaaagt 1804141 caggctgcag tcagctcgaa ttggaacttc cacaggaagt acgggaggaa gcgccatgtt 1804201 atatcagcag cttaaagccg agcatcggac acggtgaact cgtctcaggc atggctgctc 1804261 ttatgaaggt cagcatggcg atgaagcatc aaacaatacc aggcatatcc ggattttcgt 1804321 ctttgaatga ccaggtgtca ttaaagggca cccgtttccg agtgactgcc gagaatcagc 1804381 aatggaggga tttaagtgac gatgcaggca aaaaaattcc gcgcagagcg agtatcaaca 1804441 gctatagctt tggaggcgta aatgcgcacg tcattttaga agaatatatt cctttaccaa 1804501 aaccaccggt tagtatgagt gagaatggtg cccacattgt agttctttct gcaaagaatc 1804561 aagacaggct aaaagcaatt gctcaacagc agcttgacta tgtgaataaa caacaagaac 1804621 tgtcattaca agattatgct tatacacttc aaaccggccg agaggaaatg gaagaccgcc 1804681 tggcgctcgt cgtccgcagt aaagaagaac tggtaatcgg cttgcaagcc tgcttagcag 1804741 aaaaaggcga taagctgaag agttctgtac ctgtctttag cggaaatgca gaaaatggct 1804801 cgtcagatct cgaagccttg ctggatggtc cattaagaga aatggtgatc gagactttgt 1804861 tgtctgaaaa caaccttgaa aagatcgcgt tttgctggac aaaaggggtg caaatcccat 1804921 gggaaaagct ttatcaagga aaaggtgccc gcagaatacc gttgccaacc tatccatttg 1804981 aaaagagaag ctgctggaac ggctttcaag cagtagagaa tacgccttct gtttcacagg 1805041 atgagcgtat caacaacagc agcgatcatc acatattagc aaatgtacta gggatggctc 1805101 cggatgaact gcagtttcat aagccattgc agcagtatgg atttgattca atttcttgca 1805161 tacagttatt acagcaattg caatcaaagg tggaccctct cattgtcttg acggagcttc 1805221 aagcatgcca tactgttcag gacatgatgg acttgatcgc aaagaaacag gaggatacat 1805281 ccttacaaaa tgatcaagct cgcacgtttc cggaattaat accgttaaat gacggcaagc 1805341 gggggcgccc tgtcttttgg ttccatggcg gagtaggagg agttgaaatc tatcagcaat 1805401 ttgcacaaaa gagccagcgc cctttttacg gcattcaagc cagaggattc atgactgatt 1805461 ctgctccttt gcacggaatt gaacaaatgg cttcctatta tatagagatc attcgatcca 1805521 tacagcctga aggtccttat gatgtaggcg gatattcctt aggcgggatg attgcatatg 1805581 aagtcactcg ccagctgcaa agccaaggcc ttgctgtcaa aagcatggtg atgattgact 1805641 ccccatatcg ttctgagaca aaagagaatg aggcatctat gaaaacgtca atgctgcaaa 1805701 caattaatac gatgctggca tcgattgcga aacgggaaaa gtttacggat gttctcatca 1805761 gccgtgaaga ggtggacata agcttagagg atgaagaatt cctgtctgag ttgattgact 1805821 tggcaaaaga acgagggcta aacaaaccag ataaacaaat acgtgcgcag gctcagcaaa 1805881 tgatgaaaac acagcgcgcc tatgatttgg agtcgtacac tgttaagcct ctccctgatc 1805941 ctgagacggt aaaatgttat tatttccgca acaaaagcag gtctttcttt ggtgatttag 1806001 acacttattt cactttatca aatgaaaaag aaccgtttga tcaagctgcc tattgggagg 1806061 aatgggagcg gcaaattcct catttccacc tggtggatgt cgattcaagc aaccacttca 1806121 tgatattaac cgaaccgaaa gcgtcaacag ccctgttaga attttgcgaa aagctctatt 1806181 caaacagggg agtagtgaat gcgaatttcc ttaaggcttt ccggaagaaa catgaagcga 1806241 gggaagaaaa agaaacagat gaattggtga agcgctgaga aaacacaaac gccccctctt 1806301 ttaaaagggg gcgttttgaa tgttattttg aaagtgaaac agggagactt tctaatcctc 1806361 ttaaaaagac attttttctc cattgaatgt catcaggtgc aaccgcaagt tcaatatcag 1806421 gaaatctctt caaaagtgct ttaaatgcaa tgtggccttc cagcctggca agaggcgctc 1806481 ctaagcagaa atgaatgcca aaaccaaaag aaatatgtct attaggcgac cgatttatat 1806541 ttaatatttc ggggttctca aaaaaattcg ggtcgcgatt ggcagatccg atgcctataa 1806601 aaatcatgtc tcctcttttg atcgaatgcc ccttatatgt aaagtcttcg atggcccacc 1806661 gatttgccat cataacgaca ggtgaggtgt atcgcagcaa ttcttcaacc gctgtagcga 1806721 tcatttcagg ctgctgcttg agcttctcac attccttctt gtgctgcagc aatgcgaggg 1806781 tgcctgagcc gagtaagtta acagttgttt caaggccggc tacaacgagc aagaacagca 1806841 tcgaatagag ctctttttcg cttaacttgc tgccgttttc ctcagcatgc acaagtttgc 1806901 tgattaaatc gtcttttggc tttattcttc tgtcatggat cagcttagcg atataatctt 1806961 taaattcacg aagggcctga tttgtcagct ctctattacc ttcagaggta tcaaccatcg 1807021 cattggtcca gatttgaaac tgtgaccgat cttcttttgg gattcccatc aattcagata 1807081 taacaataaa aggcaaaggg gaagcgaagg atttcatgat atccgcttta ttttcttttt 1807141 ccatttcatc taaaagctgt tcagcaattt gttcaatgct gccgcgcaga ttttcaatgg 1807201 ttcggggagt aaatgcttga tgaacaagtg atctcaggcg ggtatggtca ggtgtgtctt 1807261 ttgccagcat atgatcggat acaaaatcga tatcttcact aacgttgagc attttgattt 1807321 gttcttggtt catcacattt tttacgtctc ttgtaattcg attgtctttt aaaaaggcca 1807381 tacaatcatc gtatcgggta attaaccagg ccggatatgt ggctccgaac cgttttaatt 1807441 caaatcggtg aatgggctct tcctctctaa atcgtcctaa aactgaaaaa ggattgtgat 1807501 gaaactcttt accatgcgga tgaaacatca atttttccat ttgcattctc ctcgcctaat 1807561 agggtaaata gatgaatcaa attgctgaat tagtttacaa aaaacagaat gatttgaaat 1807621 gtaatcctgt ctctaaaact atatatctat cttaggcgtc attcaatagg gagaagaacg 1807681 aaaaaagtga aaaaacggct cgatataaag cagcgccttt gaacgaaagc tcaaaggcgc 1807741 tacgctgtat tattttgatg aaagtggctg tcagctgtgc tggatatcaa ttgtatatac 1807801 tgcacgatct gttacgacct tcaatccttc gttttcttgg tgaatatgaa gctcacctaa 1807861 taaaggaatc tcataggcat tttgcggaag cggtacgttt ccgtcctcag tgaatgttgt 1807921 tccttcgcct tctaaaacaa gctcttcttt cgcaacataa tcatcaggat gattcgtact 1807981 gcgtatagcc actttttgaa ggtggagaac aatctgatcc aagtctgata tctcttcatc 1808041 atgggtcaat tcaccttttc taatatcaag cgtctggccg acttttgatt ccagccattg 1808101 agaaagctgt gtattcgtgt gtgccatcaa tattcctcct tttgatctac acgatactat 1808161 tcccaattgc tgcatctttt acacgggaaa gagccgcccc actctttatg tatgaaacag 1808221 ttcgctgttg agtgccttga tatagcgtac ggcagaacgc tggaccgatt cgtcggcatt 1808281 ttctttgaca actttagaga aagcattgta aagccggttg aattgaagcg gttttacttt 1808341 ggctgctatt tcttcaactt tggaggcggg aaggggaatg agatttgggt agctgtacat 1808401 aaagctgacc cagtttcgat ccgccgcaac cgtaatgata tctccggtca atagacagcc 1808461 tttcccttca ttgcccttgc tccaatgcaa aacagcaccg cctttaaaat gtccgcccag 1808521 tcggtaaagg tccagtcccg gcttcatatt gagcgtttcc cctgaccaga agtgaatgtg 1808581 attgcttggc cttgtcaccc attctttatc atcctcatgg atatagatcg gcgcctgaaa 1808641 cgcttcagcc cactcaacct gagtagagta ataatgtgga tgagacaagg cgatggcttg 1808701 aataccgcct aattcgttga tttggtcaat tgtcttttgg tcaagatatg tcatgcaatc 1808761 ccacagcaca ttgaagccct tatgctgaat aagatgggct gtttgtccaa tcgcaaactc 1808821 tggttcagtt ttgatgctgt aaagatgctc ttcttccttt ttaaggatgt tttgaaggtt 1808881 tcctttctca cgcatgtctt caagggttgt ccaagtttgt ccatcgggat gaatatactg 1808941 tctttcatcc tcgcaaatca gacacgagtt gggcggatct acagtctgtg catgttgcac 1809001 accgcatgta ttgcagatat aatatggcac tttcttcact tccttcatct attttccatt 1809061 attttacctt atgattatga atattcaaac gaaaaaaccg gcagttctgc tgagagagaa 1809121 ttgccggctt ttgatgatgt ttattggccg ggaacggaat tttctgcgtt gacagcgccc 1809181 gctccgtaga tattcggatc ttcatctttc catttgtccg tgccgttttt caaaagctct 1809241 tttacttcat caggggtaag atccgggttt tgctgaagaa ttaaagctgc gattcctgcg 1809301 caaatcggtg ttgccatcga ggttcctgac attgtaaagt actgagaccc tacacggctt 1809361 gacttttgga gcttatcaat ataagaattc ggagagcgaa gggaaataat attaacaccc 1809421 ggcgctaaaa tatcgggctt ttctttcccg tatactgtcg ggccgcggct tgagaaggaa 1809481 gcgacagtat catcatcgct gcttgcagta ttgttatcgt caagcgcacc tactgtaatc 1809541 accttttcgc tcacgcccgg gcttgcaatg gtctgcgaat cagggcctga gtttccggca 1809601 gcgacacaga cgacaatccc tgcgctccac gcttcctcaa ccgctctgac taacggatct 1809661 tcctgttcat gatcatatct aagggcatcg cccccgagcg acatgctcat aatatcaatc 1809721 ggttcatcgg ggttgtcctc attgtattga atacaccact caacaccctc tataatatct 1809781 gctaacgttc ctgaaccctg cttgtttaat acctttacgc cgatgagatt ggcttccggt 1809841 gcaggtccgc ggtattgacc ggaagaggat gcaccgctgc ttgcgacatc acctgcacag 1809901 tgtgtgccat gaccattatc atcgtacggc tctgtttttt gattgaccat gtccgcgaat 1809961 ccgataattc ttccttctag atcaggatgc gggtagattc ctgtatcgac aacagcgaca 1810021 gtaacacctt ttcctgtcag ggtttgcccg tttctgacga cttccttcgc atggcttgct 1810081 tcggttgccg tgtctaaaag cgctttgact tcgcggttta aatacacttt acggatattg 1810141 ctgcattcag agagaaggga atgtaatgct gaaggagtaa cctcggcgct gcagcagttg 1810201 attttgttga agcggctttt tagcttgctg cgtttttctt tttgcagcac ctctccagcc 1810261 atttgaaagc cggtctcgtg acagccttcc tcaaattcga taatgactga catttttttt 1810321 ctgttttgca atttggtttc gaaaaattta tgcaagaagc aaggagtcca tttgaagggc 1810381 ttgtaaagtt gcaatacggt ttcccgtaac ggccaatcta gcttgtgagc atttgctctc 1810441 accatttgta ccatagagta cccaaacatg tattttcctc ctattataag gttctctgta 1810501 tactctatga acagatgata ggtttggtaa gtttgtttgt cctctgtaag agacagacaa 1810561 gagtttgttt ttctgaatct ttcgcattag atacgataga ttcagaagct gaggaaatca 1810621 ttggggattg aaaaagaacg tttgttcgta ttataatgtg atcatatcaa actgggaagg 1810681 ggagagcaac cgtatgaatt tctacttgca ccgatctttg gaaagccaaa tgccaatcag 1810741 cattatatat gaagaaagac ggaacgatta gtaaaagaac gattattgtg agacagaaaa 1810801 gcaaaacgaa aatcaaagca ttttgttttt cgaaacaaca gatcagaaca tttttattgg 1810861 actctatcct ctcctgtgat tttgtgagaa caaataagca aaatctctat tctgcaggcc 1810921 ggtaacagct gtccgtctca gcaaccgggc agcctgttac taaaaccctc cttaaaccta 1810981 tatacattta tttgccaagt gaggttgttc ctaccttttt tgtctttcct ctcaaccttt 1811041 tttcactctt atttgaaatg aaccgctaat aaccgtgaca atcaattgat tttttgaaac 1811101 cgggaacttt ttcactgatg atattgtgta tacaatggta agataaaacc tattggctaa 1811161 acctcatata atgaaccgcg ccattcttat gaaaggagtt aaacatgaga agatttttac 1811221 taaatgtcat attagtctta gccattgtct tgttcttgag atatgttcat tactcattgg 1811281 aaccagaacc atcaaatcag ccagatacat attcaaattt cagcagcttg gcagagaatg 1811341 agagcccagc cgattacgat atttcatata atgagaaaaa aggaagcaaa gtcttaatta 1811401 tgtctccgca tggcggaaga attgaaggcg gagtaagtga gcttgtgcgt tatttcaata 1811461 atgaatactc tacataccta tttgaagggt tgaagtccca tgataaccaa acactgcaca 1811521 ttacaagcac caactttgat gagccattgg caaaaaagaa aatcaaggag catcaatatg 1811581 tggtggcttt tcacggatat aaaggagaga acaagaatac ccttgtaggg ggaacagacc 1811641 gaaagcgggc gaaaatgatt gtgagagccc ttgagcggag agggttttcc gctgagttag 1811701 cgtcgtctaa aagcggtctt gctggattga atgccgaaaa cattaataac caaggggaaa 1811761 cggggctaag tatccagctg gaaatcagcc gtgagcagag agaagcattt tttgatgatt 1811821 tttattataa aaatagaaaa tacacaaaga acagtgaatt ttatgcttat gtcagtgcga 1811881 tcaaaggtgt cctggaaaaa gagtattcgt aacaagcaga tcagaagaca aaataagaga 1811941 agatcagtag actgaaatag gataaaaaag gaggcaaaac aatggcagat catcattttt 1812001 atttaaaagc gaactggccg ggtaaccgta atgatgtcgg tacgatcgaa agcggaaacc 1812061 tgatcacatc gatttccatt cctaaagaaa tggatggccc gggagaaggg accaacccag 1812121 atgaaatgct tctcggggcg gcagcgacct gttacattat tacacttgca gcgatgatgg 1812181 agagaagcgg gctggaaaaa gaagacttac agatggagtc agaaggcatt gtcaacgtta 1812241 caaaaggagt ctttacatac aaaaagatca ttcaccgtcc ctctgtcgtg cttaaacatg 1812301 atgcttcaca agacgacgtc gcattggcgc acaaactttg taaaaaagcg gagtcgtcat 1812361 gcatgatttc gcgtgcaatt caaggaaatg tcgagctgca gcttgaagcc tctgtgaaac 1812421 tgggtggaga ataaagaaaa cagacggtca ctcacaggcc gtctgttttt tatcttcagc 1812481 gtgggctttc gattgattta gcacgaccac gcctgcaatg acaagcgtga gaccgaatac 1812541 accttttaaa ctgatggttt cgccaaaaag caaaaacccg acaattgctg taagcgcggt 1812601 accaacgccc gaccatgttg catacgcgct tgataagtca attgttttta aagaaaagct 1812661 tagaaacgta aaagcagaaa gaaatccgac tatgactccg gcaatgggcc aggcttgtgt 1812721 aaatccttct gaaagcttca acatcgtgct cccaaacact tcagatacaa tggcgagagc 1812781 caaataaagc aatcctctca tcttcatcac tcctttacgg ccaattaagt aacacgaccc 1812841 ctgatagtaa taaaagaatc ccgataagcc ctttggcatt cagatcttcc ttgaaccatt 1812901 ttactccgat cactgtcgtc agcaccgtgc ctgccccgct ccaagtcgca taggagaggc 1812961 tcaggggaat atggtttaaa gtcagggaca gcatataaaa ggcgagggaa tagccaataa 1813021 cgaccaaagc acttggcttc cactttttga agccatcaga tactttcagc atggctgctc 1813081 ctatcgattc cgaacatatg gcaatcgtga ggaatatata tcctatcaac atcatgaatt 1813141 ctcctcacta tatttttaga ttagaaaaaa aacttcagct agaaaaatat tagtgtatgc 1813201 ctatgtatga gtcaagagat tcattttcac acacttaaaa agaccccttt ttaaggggtc 1813261 ttttgcgttt aataataaaa agggaacggg gcatacggat aataggggta tccgccatac 1813321 aaataaggat taaataaagc gcttcctata agcccgcctg caaggccgcc gataaacggt 1813381 cctccaaaaa atccgaatgg ccggccaaac ccataaccaa atccgggtct tccaaacccg 1813441 taaccgaacc cgaacggtct tccaaaccca aatggtctcc cgaatccgaa cggccttcca 1813501 aatattcttg tatcttcagg gctgaaatgc tctaactcgt tcatgttttc tttcctcctg 1813561 taataaagtg tagatgatgc agtgtattca ccctgcccgg atttgattgg gcgaatcgag 1813621 gaaaaggagg atgtgaacac attgggcctg tatcagtctg actggtcaaa agcaccgccc 1813681 cacgcacatg cttatcatgt caaaacaacg agagaacagg gccattatca tctcatcgaa 1813741 gggtttactc agccggcaaa cggatcaaat accgatcagc atacacatta ctatacaggg 1813801 atcacttcat ttgaaaacgg ccattttcat cggtattacg gaatctcagg accggcgatt 1813861 cccttagcag atggcacaca ttatcatgaa atcgaagaaa cgacgtatct ggcctataac 1813921 gagccgattg agatccagta cggaggggtt gtgtacgatc ccggagatga cagaagaaaa 1813981 acgcatcgtc ataccctgaa aggaaagaca agggaaattg tcggcaatga gccgctcggc 1814041 tggtagaagg atgtttaccg atgcaaaaaa agggcaaaat ggataggtgg ttgtccatgt 1814101 tgaatgctat aatgggggga gatttataaa agagagtgat acatattgaa taatacgaag 1814161 cagcccgttg tcattttagt cggaccgacg gcagtgggga aaaccaattt aagtattcag 1814221 ctagccaaat ccttaaacgc ggaaattatc agcggagatt cgatgcagat ttataaaggg 1814281 atggatattg gaacagctaa aattaccgaa caggagatgg agggagtgcc ccatcatctg 1814341 attgacattt tagatcccca agactctttc tctactgccg attatcaaag cttagtaaga 1814401 aataaaatca gcgagattgc aaatagagga aagcttccga tgattgtcgg cggtacaggg 1814461 ctttatatac aatctgtgct ttacgattat acatttacgg aagaggcaaa tgatcccgtg 1814521 tttcgagaga gcatgcaaat ggctgctgag cgggaaggcg ctgactttct tcatgccaaa 1814581 cttgctgcag cagatcccga ggcagcagct gcgattcatc cgaataatac aagaagagtc 1814641 attcgcgcac tggaaatttt acatacgtcc ggaaaaacga tgtcccagca tttgaaggaa 1814701 caaaaacgag aacttctgta caatgcagtg ttaattggcc tgacaatgga tagagacacg 1814761 ctttacgaaa gaattaatca gcgggtcgat ttgatgatgc agtcaggcct tcttccggaa 1814821 gtgaaacgct tatacgacaa gaacgtgaga gactgtcaat caatacaggc gataggctat 1814881 aaagagctgt atgcatattt tgacggtttt gtgacacttt ccgatgctgt cgaacagcta 1814941 aagcagaact cgaggcggta tgcgaaacgc cagctgacgt ggtttcgcaa caaaatgcag 1815001 gtcacatggt tcgatatgac accgcctgtt gatatggagc tgaaaaaaaa ggaaattttc 1815061 acacatatag caggaaaact cgaactttaa tcgaaactgt atgatataga gaatcaagga 1815121 ggacgaaaca tgaaaccgat taatattcag gatcagtttt tgaatcaaat ccggaaagaa 1815181 aatacgtatg tcactgtttt tttgctgaac ggctttcagt tgcggggcca ggtgaaaggc 1815241 tttgataact ttaccgtatt gttggaatcg gaaggtaagc agcagcttat atataaacat 1815301 gcgatctcaa cgtttgcgcc gcaaaaaaac gtccagcttg aactcgaata gatcaaaaaa 1815361 tgccatgtca agacatgagg aaaggctgtc gggggttccc ggcggccatt tttaacatga 1815421 atccactttt gctccaagct ttttgtgtaa gctgaccatg ccaaggcacg gtcttttttt 1815481 atgagaacaa catacggaag taaaaatggt atattatgta taaaatgaat ttgggagtga 1815541 tcgatcttgt ttgaaagtga agcagaactg agacgaatca ggattgcact tgtatggata 1815601 gctgtctttt tactgttcgg ggcgtgcggg aatcaagata ccattattga aacagacaac 1815661 ggcaattcag actatgaaac gcctcagccc acctcgtttc cacttgaaca taaccatttt 1815721 ggcgttatgg aggacggcta tatcaaaatt tatgagtata atgagtcccg caatgaggta 1815781 aagctgaaga aagaatacgc ggatgatgag cttgaataaa attcacaagc attcgaattt 1815841 acaaagcgga tgccagccgc taaactaaat acagacacag atcaaacaga gggtgaaaac 1815901 atgaagcata aagtgatcgt gaatcattgg gaagaaattt gcgaagatga ttcttgctat 1815961 gaatacggaa caagtatcat tgtgaacgga aaagaattaa tcagagaagc gtcaattatc 1816021 actgctttga aggcggtttt agaagagatc ggcgcggatg ttgaaataga agaaacagta 1816081 gagagcgaaa aatgctgtga tagcttaaga aaaaaaaatc tagactacta agcagttttt 1816141 tttcatgtta tgatatacat cggctaaaaa cgacaccccg agtaggacga gagatgattc 1816201 tcgttctgct ctcttttttg ggccctaatg agtctgcccg tttgcctgat ttgatcaaaa 1816261 tatgaatttt tcataaaaac gaatctatat attgtgtttt tgctagaggg tagtatacta 1816321 tatatagtgt tagtgatgag agattcatat tttttgatag gtcgtgataa aacgtggtac 1816381 aaatcatatt tgattcgaaa acagggaatg ttcagcggtt tgtgaataaa acaggctttc 1816441 agcagatacg caaggtggac gaaatggacc acgtggacac tccgtttgtt ttggtcacct 1816501 acacgacaaa cttcggccag gtaccggcat caacacaatc atttctcgaa aaatacgccc 1816561 atctcttatt gggagtcgct gcgagcggca acaaagtatg gggcgataac tttgcaaaaa 1816621 gcgccgatac catttcaaga caatatcagg tgccgatctt gcacaaattt gaactcagcg 1816681 gcacatctaa agacgttgaa ttgtttactc aggaggtaga aagagttgtc acaaaatcaa 1816741 gtgccaaaat ggatccagtt aaataacgaa atcatgatcc aaaaagatgg gaaattccag 1816801 tttgataagg ataaagaagc tgtacatagc tattttgtag attatatcaa tcaaaacaca 1816861 gtcttctttc acaatttaaa agagaagctg gattatttgg ttgaaaacca atactacgaa 1816921 gaggaattct taagccttta ttcttttgaa gacattaaag aagtgtttaa gacagcttac 1816981 gctaagaagt ttcgttttcc ttccttcatg agtgcgttta aattctataa tgactatgct 1817041 ttgaaaacga atgacaagaa aaaaatcctc gagcgttatg aggaccggat ctcaattgtt 1817101 gcgctgttct tcgctaacgg cgacactgag aaagcaaaag aatatgtaaa cctgatgatc 1817161 aatcaagaat atcagccgag cacaccgaca tttttgaatg ccggcagaaa acgccgcggt 1817221 gaacttgtga gctgcttctt gctcgaagtt aatgattctt taaatgacat ttcaagagca 1817281 atcgatatct ccatgcagct ttctaagctt ggtggcgggg tttctcttaa cctgtccaag 1817341 cttcgcgcga aaggtgaagc cattaaagat gttgagaatg cgacaaaagg cgttgtaggc 1817401 gtcatgaagc ttcttgataa cgcgttccgt tacgctgacc aaatgggaca aagacaaggc 1817461 tccggcgcgg cgtatttaaa cattttccac cgcgatatca atgattttct tgatacgaaa 1817521 aagatttctg cggatgaaga tgtgcgtgtc aaaacgcttt cgatcggtgt tgtcattccg 1817581 gataagttcg ttgagcttgc acgcgaggac aaagcggctt atgtattcta cccgcacacg 1817641 atttataaag agtacggcca gcacatggat gagatggaca tgaacgaaat gtacgacaag 1817701 tttgtcgaca accctcgggt gaaaaaggaa aaaatcaacc cgcggaaact gcttgaaaaa 1817761 ttggcgatgc ttcgttctga atcaggctat ccatacatca tgttccaaga taacgtcaat 1817821 aaagtgcatg cgaataacca tatttccaag gtcaaatttt ctaacctttg ctctgaagtg 1817881 ctgcaggcat ctcaagtttc ttcatacaca gactatgatg aagaagatga aatcggtctg 1817941 gatatttcct gcaacctggg ttcgcttaac attctcaatg tcatggagca taaatcaatc 1818001 gaaaagacag tcaagcttgc gacagactct ttaacacacg tgtctgaaac aacagacatc 1818061 cgtaatgcgc ctgctgtaag acgggcaaac aaagcgatga aatcaatcgg cctcggtgct 1818121 atgaaccttc acggctacct tgcgcaaaac ggcattgcgt atgaaagtcc ggaagcgcgt 1818181 gactttgcaa acacgttctt tatgatggtg aatttctact ccatccagcg ttctgcggaa 1818241 atcgcaaaag agaagggcga aacgtttgat caatatgaag gatcaaccta tgcgacaggt 1818301 gaatacttcg acaaatacgt ttcaactgat ttctcaccga aatacgaaaa aatcgctaat 1818361 ctgtttgaag gtatgcatat cccgacgaca gaggactgga aaaagctaaa agcatttgtc 1818421 gctgaacacg gtatgtatca cagctacaga ttatgcattg cgccgacagg ctctatctca 1818481 tacgttcaat caagcacggc gtctgttatg ccgattatgg aacggattga agaacgaaca 1818541 tacggcaact caaaaacgta ctacccaatg cctgggcttg catctaataa ctggttcttc 1818601 tataaagaag cctacgatat ggacatgttc aaggttgtgg atatgatcgc cactatccag 1818661 cagcacattg atcagggaat cagctttaca ttgttcttaa aagacacaat gacgacccga 1818721 gatttaaacc gaatcgatct gtatgcacat catagaggaa ttaaaaccat ttactatgca 1818781 agaacgaaag atactgggca agacagctgc ctttcttgtg ttgtttgatt aaaggagagt 1818841 ttatagtgac aaaaatttat gacgcagcaa actggtcaaa gcatgaagac gattttaccc 1818901 aaatgttcta taaccaaaac gtgaaacagt tctggcttcc ggaagagatt gctttaaacg 1818961 gcgatctcct cacatggaag tacctcggaa aaaatgagca ggacacttat atgaaggtac 1819021 tggccggact tacgcttctt gacacagagc aggggaatac ggggatgccg atcgtggctg 1819081 aacacgtaga tggccaccag cggaaagcgg tgctgaactt tatggcgatg atggagaacg 1819141 ctgtccatgc gaagtcgtac tctaatattt tcatgaccct tgcaccgact gaaacgatca 1819201 atgaagtatt tgaatgggtt aaacaaaata aatatttgca gaaaaaagcg caaatgattg 1819261 tcgggcttta caaagccatt caaaaagatg atgaaatttc actgttcaaa gccatggttg 1819321 cttccgtcta tctggaaagc ttccttttct acagcggttt ctattatccg ttatatttct 1819381 acggacaagg aaaactgatg caaagcggtg agatcattaa cctgatcctt cgtgacgaag 1819441 cgattcacgg cgtgtatgtc ggtctccttg ctcaggaaat ttataataaa cagacagaag 1819501 agaaaaaagc agagcttcgt gaatttgcga tcgacctcct gaatcagtta tatgaaaatg 1819561 agcttgagta tacagaggac ttgtacgatc aagtcgggct ctcacatgat gtaaagaaat 1819621 tcatccgcta taatgcgaat aaagcgctga tgaaccttgg atttgatcca tacttcgaag 1819681 aggaagacat taatccgatc gttttaaacg gattaaacac aaaaacaaaa tcgcatgact 1819741 tcttctctat gaaggggaat ggctataaaa aagcgacagt tgagccgctc aaagatgatg 1819801 acttttattt tgaagatgaa aaagagcaga tataatatct gctcttttcg gcttgaaggt 1819861 tcaaatgagg aggacgcagt acccatggga aaaatggacg aaatgatttt agttgccccg 1819921 cgcgatgatg tgtttaaaaa agaaagctta accttccagg gcgtgtacag tgaagatagc 1819981 agagtagcag aaatcatggc tcagattgaa gcggcctatc gtgaaatgag aagaggggac 1820041 gcagaagaag atccgcgttt caagcagccg ataccttatg tcgtcattaa gcgtgaagat 1820101 gaagtttttc tttacgagcg gctggctggc ggcggtgaat cacgtctgca caacaagctt 1820161 tctctcggtt ttggcggcca tatgaacgcc atcgaagggg cagcttcatt tgctgaagtc 1820221 ttaaagctga acacagaccg tgagcttgag gaagaactgc aaataaatga agaagataaa 1820281 caggcgattg tcacactggg attgatcaat gatgatgaaa acagtgttgg caaagtgcat 1820341 atcggtattc tttctgcgct tcaattaaag cctggcgcac aagtggaagt gaaggagaaa 1820401 gaacaaattg cgggtaaatg gatgaaagtt tctgaattaa aacaggatga tatctacaac 1820461 cgtctggaaa catggtcaca gtttgttgtt gatattcttg aataaaaaaa cccggtttct 1820521 cgcgatgagg agccgggttt ttttatgaga cgctcgtccc cgtctcggct atgattctag 1820581 gatcacaata gcgtcaaagc cggcattttt cgctctggca gcgagggtgt ctgcattgtc 1820641 tttggatgaa aatgcgccaa tctgcacttt gtataatccg tcctttaaaa ggacaatcga 1820701 gtcaaaacct ttggcttcgg cattacttgc gagcgagtcg gcattcgctt tgactttaaa 1820761 tgcgccgatt tgaaccttat ataaccctga gctggaagtc tttttaaggt taaaggcttg 1820821 ctccagcccg tttgcatgtc ctctcgctaa gctttgaata aaactgctcg ttttcagctt 1820881 atttgcatcg gaaacggtat caatgaagcc gttctcggtc aagagggcag gcattgccga 1820941 ctcccttagg acgtggaagt tcgctgtttt tttgccgcga tcggcaaagt cgacagcttg 1821001 tatcacttca gagtgaattg tcgattgata agtcgtcgtc ggggctccta catctggata 1821061 aatatagctt tcaaaacctg tgcctccccc ggaattaacg tgaatggaca aaaagaaatc 1821121 tgctccccag ttatttgcgg catttgtccg gtcgtttaag ctgacatatt ggtcgcttgt 1821181 ccggctcagc agcagagaaa cgccttcata ttcattagtt aatatcgtac gtaaggctaa 1821241 agcgatttgc agggttaacg ttttctcctg aaggccatta cctgttgcgc ctggatcaga 1821301 cccgccatgg ccaggatcaa taaaaatttt aaccattttt catcacctca ttacaggata 1821361 tgaaaaaaca cggcttctgc ttgtacgatt atcattcaac tgaaaaatga ggaaataacc 1821421 ctttcacatc cagaaattat ttctcgggaa agcgcacaat tcaacatgaa gcgacaacag 1821481 atacggtccg acatgaaatc tgtgcatacg ccatatgttt gtatgtacta tgggttcggt 1821541 taacctgcac tgattcctgc tggttttaag ctttgcgttc atattaaatc aagcatttaa 1821601 aacgtaaatt gatgaggaaa gctcctttca ttaaagacac cgctttataa atcgaaaaaa 1821661 agaaaaacac ttcaggtatc ttagggcggg taatacgttt cgtacaaaaa tcagcccgtt 1821721 gtatgaaaaa gaaataatga gaaagaagct cactataata ctctgacaaa atgattaaaa 1821781 acaaaatctc atggtttgtc caccccatgt ccgtgaatac aataagaaat aaagtatttc 1821841 tcgggaaagc gcaggattcc ttattgttcc cgaaaaaagc aattgtttcg acacatgata 1821901 ggcgtttgtc acaatcggca tccgcttgaa tatcatatag agagaacaga gaggtgaaga 1821961 tgttggagcg cgctgtgact tataaaaaca acggacagat caacattatt ctgaacgggc 1822021 aaaagcaggt gctgacgaat gctgaggcag aggcggaata tcaggctgca ttgcaaaaaa 1822081 acgaagcaaa gcacggcatt ttgaaggaaa tcgaaaaaga gatgagcgca ttagttggga 1822141 tggaggaaat gaaacgcaac atcaaggaaa tatacgcctg gatttttgtg aaccaaaaac 1822201 gcgcggagca aggcttgaag gttggaaagc aagcgctgca catgatgttt aaaggaaatc 1822261 cgggaacggg aaaaacgacg gttgcacggc tcatcggcaa gctgttcttt gaaatgaatg 1822321 tcctgtcaaa aggccactta atagaagcgg agcgggctga cctggtcggg gagtatatcg 1822381 gacacaccgc ccaaaagacg agagatttaa tcaaaaagtc attaggtggc attttgttta 1822441 tagacgaagc ctactcgctg gcaagaggcg gcgaaaagga ctttgggaaa gaagcgatcg 1822501 acacacttgt aaagcatatg gaagacaaac agcatgagtt tattttgata ctcgccggat 1822561 attcacggga aatggatcat tttctctcgt taaatcccgg actccaatca agatttccca 1822621 tctccattga ttttccggat tactctgtga cccagctcat ggagattgcg aaacgaatga 1822681 tcgatgaaag ggaataccag ctcagtcaag aagcggaatg gaaattgaaa gattacttaa 1822741 tgacagtgaa aagcacgaca agtcccatta aattcagcaa tggacgtttt gtcagaaatg 1822801 tgatcgaaaa atcgatcaga gcacaagcca tgaggctttt aatgggagac caatacttaa 1822861 aaagcgactt gatgaccatc aaaagccaag atctttccat taaagaagaa gcatctggat 1822921 ctgcatagac ctctcagttt ttgagaggtc tgttttttgc tcgtatttcc gcttttcaaa 1822981 gcaatcgatt tgtggtatac acatgcaggg tttggtatga taatactact gcccaatatg 1823041 caaaagaaag gaacatccat ttgaacgaac aagaaacgat tcaggagaaa gccattttag 1823101 tcggatgtca gctgccgcat atcacggatg agcattttga aaattctatg gaagagctag 1823161 catctctgac gaaaacagca gacggaaaag tactgaccag cgtcacacaa aaacggaaca 1823221 gggctgacgc cgctacatat ataggaaaag ggaaggtaga agagctgaag gcactcgtgg 1823281 aagagcttga agctgatctc ctcatcttta atgatgaact gtcgccaagt cagctgaagt 1823341 cattggcaac agcaattgaa gtgaagatga ttgaccgcac gcaattgata ttagatattt 1823401 ttgcaaagcg ggcgagaacg agagaaggca aacttcaaat tgagctggct cagctgcaat 1823461 atgcactgcc gcgtctgacg ggacaaggga tcaacctttc ccggcaaggc ggaggaattg 1823521 gggcaagagg tcccggggaa acgaaactgg aaaccgaccg ccgccatatc agaaatcgca 1823581 ttcatgaaat caacacacag ctttccactg tcattcgcca tagaagccga taccgtgaaa 1823641 gaagaaagaa aaacggtgtg cttcaaattg cgcttgtcgg ctatacaaac gcagggaaat 1823701 caacatggtt caaccgcctg acgagtgctg acagctatga agaagacctc ctgtttgcca 1823761 cgctggaccc gatgaccaga aaaatggtcc tgccaagcgg ctacagtgtt cttctttcag 1823821 atacagtagg atttattcag gatcttccga cgacattgat tgctgcattc cgctcaacgc 1823881 ttgaggaagt aaaagaagcg gatttaattc tgcatttaat tgattcttca aatgaggatt 1823941 atgcgggaca tgaaaaaaca gtgcttcggc tgcttgagga gcttgaagca gatgatatcc 1824001 cgatgctgac ggcttacaat aaacgtgatc aaaaactgcc tgattttata ccgaccgccg 1824061 gaagggatca cattatggtc agtgcgaaat ttgaggacga cgctgcagcc tttaaagaag 1824121 cgattcagcg ctatttgcgc caagaactgt taacgtcttt tgaagcacat gtgccggcaa 1824181 gtgaagggaa gctcctttcc agaatcaaat cggaaacgat ggtagaccgc ttctatttta 1824241 atgaagaaaa tgaacagtat gacatatccg gctatgtcca agaagagcaa agtatcatcg 1824301 gtgaattaaa gaagtatatg taggaaggaa atataaagac atgtttgaca cattaacaca 1824361 cggagaatta ttgaagaaaa cggcaatgga agtggaagcg gacattgccg gcattcataa 1824421 acaaatagaa gaaatcagcg agcgaaatga gtggagagtg cttcaaagct atagaaaaca 1824481 caaagtaagc gacactcatt tcacgccgtc tactggatac ggctatgatg atatcggaag 1824541 agacacgctt gaaagcatat atgcggatgt gtttggcgga gaagcggggc ttgtaaggcc 1824601 gcaaatcatt tcaggcacac atgccatctc aattgctttg ttcggtgtcc tcagaccggg 1824661 ggacgagctc ctttatatca cgggcaagcc gtatgatacg ctagaggaaa ttgtgggcgt 1824721 caggggtgga gaaaacgctg gttcgttaaa ggattttcaa atcggctata atgcggttga 1824781 tctgacgaaa gacggaaaga tagactatga tgcagtcgcc gctgcgatca atccgaagac 1824841 aaaagtaatc ggcattcagc gctcaaaagg atatgcgaat cgcccttctt tcttaattag 1824901 tgaaataaaa gaaatgatcc gttttgtaaa agaaatcaat gaaaatctga tcgtctttgt 1824961 ggacaactgt tacggagaat ttgtggaaga gcttgagcct tgccatgtcg gagccgacct 1825021 gatggcggga tctctcatta aaaatcccgg cggcggcctt gcgaaaacag gcggctacct 1825081 cgtcggaaaa gcgaaatgga ttgaagcttg ctcataccgt atgacgtcac ccggcatcgg 1825141 cagagaagcg ggggcatctc tttactcgct ccaagaaatg taccaaggct tctttttggc 1825201 gcctcacgtt gtgtctcaaa gtttaaaggg agcggtgttt acagcgagat tccttgaaaa 1825261 actcggcttc acttcaaacc cgaaatggga tgcgaaaaga acggatttaa tacaatccgt 1825321 tgagttttct gacagagaaa agatgattgc tttttgccag gctattcaat ttgcatcgcc 1825381 aatcaatgct catgtgacgc cttatccagc ctacatgcct ggatacgagg atgatgtcat 1825441 tatggcagca gggacgttta ttcaaggagc aagcatcgaa ttatcagctg atggccctat 1825501 ccgcccgccg tatgtagcgt atgttcaggg aggattaacc tattcgcatg tgaagaatgc 1825561 catatgcagt gcagtggatt cattgatgca aaagcaatta atttaaattt tttaaaaatt 1825621 tctctggatt tgatgttaag aatccttaca tcgtattgac acataatata acatcaccta 1825681 taatgaaact aagttaagaa aaggaggaaa ttgagatgag tgataatatt cgccgctcaa 1825741 tgcctttatt tccaatagga attgtcatgc agttaactga gttatcagca agacaaattc 1825801 gatattatga ggaaaatgga ctgatatttc cagccagaag tgaaggaaat agacgattat 1825861 tttcatttca tgatgtagat aaactgttag aaatcaagca cctgatagaa caaggtgtaa 1825921 acatggcagg aattaaacag attctggcga aagccgaagc cgagccagaa caaaaacaaa 1825981 acgagaagac gaaaaaacca atgaaacatg atctgtccga tgacgaactg agacagctcc 1826041 tgaaaaacga gctcatgcaa gccggccgtt ttcaaagagg gaatacattc cgtcaaggcg 1826101 acatgtcccg cttctttcat taatccgtta gcaactgttt tgctatatac atttaccttt 1826161 taagaggagg aattttacca aatggcaaag tacactagag aagatatcga aaaattagta 1826221 aaagaagaaa acgtgaagta tatccgcctt caatttactg acattcttgg aacaatcaag 1826281 aatgttgaga ttcctgtaag ccagcttgga aaagcgcttg ataataaagt catgtttgac 1826341 ggttcttcta ttgagggatt cgttcgtatc gaagagtcag acatgtacct gtatccagat 1826401 ctaaatacat ttgttatctt cccatggaca gctgaaaaag gtaaagtagc acgtttcatc 1826461 tgtgatattt acaatccgga tggcacacct tttgaaggtg acccgcgaaa caacttaaaa 1826521 cggattctga aagaaatgga agacctcggc ttcagtgatt ttaaccttgg gcctgagcct 1826581 gaattcttct tattcaaatt ggacgaaaaa ggcgagccga cgcttgaact aaacgacaaa 1826641 ggcggatatt tcgacttagc tccaactgat ttaggagaaa actgccgccg cgatatcgta 1826701 cttgagcttg aagagatggg ctttgaaatc gaagcgtctc accacgaagt agcacctggt 1826761 cagcacgaaa tcgactttaa atatgctgga gcagtccgct cttgtgatga catccaaaca 1826821 tttaaactag ttgtcaaaac aattgcccgt aaacacggcc tgcatgcgac atttatgcca 1826881 aaaccattgt tcggtgtaaa cggttcaggt atgcactgca atctatcact cttcaaaaat 1826941 ggtgttaacg cattctttga cgaaaacgca gatcttcagt taagtgaaac agcgaagcac 1827001 ttcattgcag gtatcgtgaa gcacgcaaca agctttacag cagtaacaaa cccgacagta 1827061 aactcttaca aacgtcttgt tcctggctat gaagcacctt gttatgtagc atggagcgcg 1827121 caaaacagaa gcccgcttat ccgtatcccg gcttctcgcg gcatcagcac acgtgttgaa 1827181 gtacgcagtg tagacccagc tgcaaaccca taccttgcac ttagcgtatt gcttgctgca 1827241 ggattagacg gaatcaaaaa caaactggaa gcgccggctc caatcgaccg caacatctat 1827301 gtgatgagca aagaagagcg catggaaaac ggaatcgttg accttccagc aacacttgcg 1827361 gaagcactag aagaattcaa atcaaacgaa gtcatggtca aagcgctggg cgagcaccta 1827421 ttcgaacact tcatcgaagc aaaagaaatc gaatgggata tgttccgcac gcaagtacat 1827481 ccttgggaac gcgaacagta tatgtctcag tattaatatc tcaatccctt ggcactaaaa 1827541 gtgtcagggg attttttatg ttaataggta ataaattatg gagcggcact gctaaaaagc 1827601 agggtcactt ttagtctatg tcactaataa ttctatgtac taaattttta attagggaaa 1827661 taattccacg cttaaggaag caatacgcat aaataattcg acaaattctg tgataattcc 1827721 attgttcaat acttctacca gcaataataa gatgagtaag gtagatgttt atcattgaca 1827781 tcataaccaa atgaatccat aattacgttg aaatctaaat caattttcaa aaaggagatt 1827841 tctatgaaaa aattgactat cttctccggg ggattaggag cggttttttc tgtactggct 1827901 caactgtttg cggttataga tgactcttac actttgggga atttatggtt tttaggtgct 1827961 ttggcgggaa ttataaccat gcttgcttca atccagacaa ataataaacc agtcttcagc 1828021 atattattaa ttgctagttc agtaataggt ctacttggaa ctggtcttgt atacatcata 1828081 ccaacactgt tcaatataat aataatttat aaattttcaa aagtaagcca ataagccaat 1828141 gggaaaatta aggttctttt tttatttaac atccctttga caaggtcggt gataaatcgc 1828201 agaatgttta tgcttgcaac taatccacca gcgggggcat cggtgggcat gattatctaa 1828261 cgccatgttt ctaggatacc ggaattgaaa catttgctga ggcatttcgt gaagctgatc 1828321 accaaatgac catttccata gaggcacgtc taaagaagct atcataggag gacaatactg 1828381 tgtggaaagc tttaagtcaa ttactcaaga aacagaaaaa tcaaagtcca agcgatgaag 1828441 attatataca gattccagaa ttagaagtaa aagttttggg gatgcttcac agtatcaata 1828501 tagacctggt taatgtaata gcccaagcag aaaagtctaa ggagtttata ggacaaatcg 1828561 aaggcatctg gcattctata gcaaatcaat tttattcact cgcccaaggg tttgagaatg 1828621 aggatatcaa taagctttct gcggatcttg atcatgctgc cgccacttgg gaagctgttg 1828681 ctaataaagc aaaagagttt gtaacaaatt cataccaagg gtaaaagaaa aataagggcc 1828741 tgaaagggct cttttgctta tagtcatatt tcccgtaagt attacttttt ggatttaata 1828801 aattttaaag cgtgtttgtt tcactgaatt catagtcaaa aggggaatgt ttttatgctt 1828861 ggaatcaacg ttgaaaaatc aaatgaaaac ttaattatca attggcagct atccaaaatt 1828921 gaaattccaa tcaaagaaat caatgatgta tttcttgatc caaactatgg gggagaggag 1828981 aaaagcgcag taaggattgg gtttccttat ggctcaacag atagggtagt aattaaaaca 1829041 gcacgtaaca cttacatttt gttcaccact aatcctgctt taattatgag taaaattgtt 1829101 tcttaataaa cagtttatgt cccttttaaa tttatctatt aatgttctgt gtggtaaaat 1829161 ttagtgagat gatttaagga ggaggagcat ttatggaaga aataaaagtt agttcacatg 1829221 acactagatg gtattaagaa agcagtttct aaatatggta cattccctat gtttcatcat 1829281 ggaggatatg tcatggaaga tgctactttt catttcaaag atcctgctag tcctcaagaa 1829341 attagcgata tagaacagaa gctaggtgtt actttcccta atgactataa agagtttttg 1829401 ttacagcaca atgggatgga aatgtttgat gggattgaaa tacttagctt agagggaatc 1829461 attgaatata atgaggttca agatttccca gagggatacg ttttaattgg atatcatttt 1829521 gatggaagat atgtcataga cacaaacaaa tcaaaaaatg gattaggcta tatgctatat 1829581 ctagactcaa ttgatgatat tgaagatgcg attaacttag attctaattt cgagatatgg 1829641 tttgatatgc tagtgtcttt aaatggaacg aaatattggg aagtaaatcc gaatctccaa 1829701 gagtattata aactggtttc agaataacac ttcggcaaaa gaaaaaatta tgactaattt 1829761 caacaaccaa agaaactgca atttgaggga agtataatga caatttacga gcaaattaag 1829821 gatgctttga aaaataagat caatgagttg gtttcacctc aagaagtaaa gaaaaccctt 1829881 caagaaaaat acggaactaa tccggatagc attattttat cagattattg ttataaccgg 1829941 tataataagg ggatttcttt taataagcac ctctttgaat atatgaatag aagttcttac 1830001 aaatacttag gtgaaaactc tctttataca ggacttattt tcagaaaatc aaaaggggaa 1830061 gataaggaag ttatcgtagg cgaatgggta aacggtgtta aatcactccg agaagcttct 1830121 gttactaata accaaataaa tgatcaagcc gaaatcatta gtaaagaaca acttgtaaac 1830181 ctttataatg aatataacca aatcctgaga tatgaaatga atgtattgaa ctgtaagcct 1830241 acagaattga ggcatttaat tggcagaatc ggtgaattca tttgtgcaat ccaaaccaac 1830301 ggcactctgg cacgtcaaac taatcagcat ggatttgatg ttgtgagtga tggcagacgg 1830361 attagtgtaa aaacaacagc tcaatcaagt ggttttattt cgataaataa aaatacattt 1830421 tatgattttg atgatttttt tgtagttcaa tacgtaaatg atgattttaa agttattttc 1830481 ttcggctcaa aggaagaagt gcaaaaaata agcagaattt atggaagcca atacgaagtt 1830541 gaaatttcac ttcttaaaaa gcttaataag gaataccaat taaattaaac aatcttgttg 1830601 gtaacaaaca tcctcttact tattgtaaga ggatgtttgt ttaattctta catattttat 1830661 ctttgcaatc tggcttacga gttgcatcca cagtaaatga tcttacttcg tctttagttt 1830721 tgtcataaat tccccatatt acccctcaga gaaggatagg gggattattt tggagaatca 1830781 tattccattg cttgttcaca gtcagtaatc cttgagttgt tctagcaaga ggcaatattg 1830841 ttgaataaga atagttttaa agaggttatt gttgtcttca tattgaaata aagattaagt 1830901 atattagagg ggagttgctt taatgcacat aacaacaaaa aggttattga tacgtgaatt 1830961 tgaattcaaa gattggcaag cagtatatga gtatacatct gatagtaatg taatgaagta 1831021 tatacctgaa ggggttttta ctgaagaaga tgcaaaggca tttgtaaata aaaacaaagg 1831081 tgataacgct gaaaaattcc ctgtcatact aagagatgaa gactgtctta taggccatat 1831141 tgttttttat aagtattttg gtgaacatac atatgaaatt gggtgggtgt ttaatcccaa 1831201 ttatcaaaat aaagggtatg cttctgaggc agcccaagct atcttggaat atggatttaa 1831261 agaaatgaac ttacatagga ttatagctac gtgtcaacct gagaatattc cctcataccg 1831321 agttatgaag aagattggaa tgagaagaga aggctttttt aaaaaatgta ttccaaaagg 1831381 caatgaatgg tgggatgaat attattacgc tattttagag gaagagtgga attgaacttt 1831441 attgagtgcg gcaatacaaa caaattatca ccctctactt agaacatatt agttaaatga 1831501 aggtgatata taaagtgata tgacagtgat taaatgggat tcaatgagct ccggtgaatt 1831561 gtttttaggt gagttcacta aggatgatac ctgatacgca gccataccat tcgagcgtta 1831621 atcattttat aactgatctt ttcacttttg cccacggggg aataagaccc tatttaagtt 1831681 tgccagacga ttgtttgatc cgttgttgat gattgtcagg attttttgtg aaggaatatc 1831741 tttatatagt ggttgattat tcccttctgg taaaaattga tctatgttga attgcttaac 1831801 atgtcattga actcagagaa taaagtgaac ctgccacaga tgttcattat cttttagggg 1831861 gttccaaaaa gaccgtattc ctatcgatcg ctcagagtga aaatggtata ctaaagttac 1831921 aatcacagga aggaattaca atttttttag atctacataa aatcatctga ttaaccgaaa 1831981 gtgagaatgt gtgaatgaat ttaatagggt atattgagga aaggtttcaa aacctcgaat 1832041 taattcctag catctataat caatggggca caggaatcca tttttgtctt ggggaaaata 1832101 tctatcaact caaagcaaat gaagaattga atttaaagat gtttcggatt gtatatgaac 1832161 aaacctcaat catttttaat gaattatttg aacaaaatga tgacatattc cttgtgacga 1832221 atatgtataa gcacaaaaag aaagagaaat gtataagaaa attaaaggtg tatcaaccgt 1832281 ttctaaaatg taaaaatcat ttgaatcaaa ttatggtgaa gacatatccc tatcctttcg 1832341 aaatcaataa agctgaagaa tacgagatgc aacaattttc cctgttatgc aaacctcgag 1832401 acttacgtgt aactgaatta cttaaagcag ccagtaatga ggattttcca caaaaaccga 1832461 aattcggagg ttactctatt gattaccctg atgttttctt tgtgaacatt acaaaagaca 1832521 ttattttctt tatctatgat gaccgcggat gcgaagtcat agctcatgat ttcaaacgaa 1832581 tacgtccact ttatgaaaaa tatcacgact gggtagaaga gtataagtgc atgtaatact 1832641 ttttttaaaa acgatttatc aggaaaggca gaattagatt atgagggcct tacatacaag 1832701 atgtaaacgg ttattgaaac taagatggta ttatgtgatg atgagagatc tgcattttta 1832761 ttagtacttg atgaaagatt agtggatttt gattctcaag gtggaaacca tattagtgtt 1832821 tatttagtta ctcactttga gttatctgat caatcgtata aagatgtatt aagctttaat 1832881 gatgatcttt tgggtatgga gcataactgt tcgtatgcaa tggatattct aagcgttaaa 1832941 gaggaacttg atttcgattt cccatttaat atgcttgcaa taaaaagcta tgtacaagaa 1833001 ttaataaaaa tgttagggat tgatatcact ctgcctgaaa tgaaagaaag agattttgac 1833061 aaactttctc aaaactaaat aaaactacta tttttaaaga gaacggagac ttgctttcaa 1833121 tatgaatgtt aaaaaagctg cagctgtttt ttcaatcact attccaatta tctcagccat 1833181 cttaattatt aattttttta caggatttat gtcaattcca tggcaaggaa tgccggtgtt 1833241 ttttccatta ttactttctc ctataggaat cattttagcg ttcgtttcaa taaagacaaa 1833301 taaacggtgt gctgtatatg ggattgtctt aaatgcaatt atgtttccat ttcctttttt 1833361 ctggtttatc ggaggggctt tgttatttgg agtttaaaat ccattaggca ttacgcttat 1833421 acattggtat tttcgagctt gtcaaaagaa ggaataaaaa aacttcagaa ttgcttggct 1833481 ttactttatg ttgaaagggg tcgagtaagg tggataggaa aaaggatgaa atacaaagaa 1833541 aatataggga acaaatgagg gagaagaaag aacgagaaaa agaagatggc agttcacata 1833601 cttttgaaat tgttgttgtg ctagccatta tcattttgat gtttttcttt aattcagttt 1833661 tcaaggcttt ttagatattg tacagatgac tttcaggatg tttgaaaaaa taaccctttg 1833721 agatatatac cgcatgaaag tattgaagga cttatgaaaa ttcaagagcc agttgaatct 1833781 taataattaa tcaccaaata atggggatgt aaaatgaagt tgtataatga atttatcaat 1833841 atagctaaaa cgtttaataa agagttagac ataattccat tattatatgg atctttaggt 1833901 cttgaaaagg taactgggtt agacttttcc ccagaagata ttgatctcct tattccttta 1833961 atttttttag aggaaaagtg ggaaaaacta aaaaaagtga tggaactgca tggatacaaa 1834021 atggttgatt tacatgagca tgaatttaag aaaactaata caaaaatagg catttcttac 1834081 attgaggatt taaaaccatt tgcagatgta gactataata acctagagat ttttgaagat 1834141 ggcggagcga aatatcattt gctaacgatt gatgattacc tcaagattta taaaaagtct 1834201 ttattagatg gttatagaag aaggaagaag aatcataaag accaaagtaa aattaacata 1834261 ttgaataaat taatacggaa ttaatttctg tattcccttt tgtttccagt ctcaattaaa 1834321 atttttaaga ttaaaataag tttgaaggaa aaatcatagt gtttaacaca gccattaatc 1834381 ctcagacagt caaatagcca tttctactcc ggttgaaagc ttctctattt ttgcttctta 1834441 tttatctttc ctgtattgat atatgtatgt agggttggac ttataacata aactattctg 1834501 gccattccgt tctttcaatt catgaccggg cttgccatca gcataaatct aggctaacag 1834561 tctccataca tcctgtgatc acctttatca aactcttaaa tgcaacttac cactaaccaa 1834621 ttctttattt cgcatagatc atctttgtca tgtgtttaca caagaatctg ttttggactg 1834681 agacactgaa tataacaaaa cagtcaaaaa tcaatattta attcattctg tttaaacttt 1834741 ctgaaaaaga tgttgaaaaa gtcgaaagga ttttataata ttaagtcaag ttagtttgtt 1834801 tgatcaacaa actaatgaaa tgaactttca ttatccacaa gataagatct tactaatatg 1834861 gatggaaggg ggataagagg gtcgatttaa tggagctaaa caatataaga aacgaaagaa 1834921 tgaggctttt atccttttcc aggtatataa ggtatgacga aaaaagatga attttttgct 1834981 tgctgatcac catatttttt tgcactgttt tgaaagcgct tttataaaag tttactgacc 1835041 gtaaattcga gaaattgtta taccgtttca cactgttcca tattaaagga tcgaaaaggg 1835101 gagaaatcat gctcagtgaa aatgtaaaga agattagcat ggttgaaaaa gttggatatg 1835161 cgtctggaga ttttgcttgt aatttaattt atgcaacagt gtctacgtat cttttgttct 1835221 tctatacaga tgtttttggt ttatcggcag cagcagccgg tactatgttt ttagtggtta 1835281 gaataatcga cgctctcgct gatcctttta tcggaacaat agttgacaga acgaacagca 1835341 gatttggacg ctttagaccg tatcttttat tcggagcttt tccatttgtc atactggcaa 1835401 tactctgttt tacaacacca gacttttcgg atatggggaa attaatatat gcctatataa 1835461 cctatgttgg cttgtcgctt acatacacaa cgataaacgt tccatatggc gcgttaactt 1835521 ctgcaatgac tagaaataat caagaagttg ttagtataac ttctgttcgc atgttatttg 1835581 cgaatcttgg gggacttgtc gttgcatttt ttgttccctt actggctgct tatttaagcg 1835641 atacttccgg caacgagtct cttggctggc aactaaccat gggtattttg ggaatgatag 1835701 gcgggtgcct tttaatcttt tgttttaaaa gcacaaaaga gcgggtcact cttcaaaaat 1835761 ccgaagagaa aattaaattt acggatatat ttgagcagtt tcgtgttaat cgtccacttg 1835821 ttgtattaag tattttcttt attattattt ttggagtgaa ttccatcagt aattcggttg 1835881 gcatttacta cgtaacgtat aacttagaaa gagaggattt ggtgaagtgg tacggtttga 1835941 taggaagttt acccgctttg gtcattttac cgtttattcc aaggcttcat caatttttgg 1836001 ggaaaaagaa attactaaac tatgcattat tactgaatat tataggcctc ttagctttac 1836061 tgtttgttcc gccaagtaat gtttacctca tacttgtctg tcgattaatc gctgctgctg 1836121 gaagtctcac tgccggggga tatatgtggg cgcttattcc tgaaacaatt gaatatggag 1836181 agtacaggac tgggaaaaga atgggtgggc tcatttacgc tataatcgga tttttcttta 1836241 agtttggtat ggccttagga ggagttgttc cgggtctggt tcttgataag tttggatatg 1836301 tagcaaatca ggcacaaacc ccggcggcct taatggggat tttaattaca acaaccatta 1836361 ttcccgtgtt cttgcttgtt ctagctttaa ttgatattaa tttctataac ttagatgaga 1836421 aaaaatataa aaacatggtt cgagaattag agaatagaga caaagtttat ttggatcata 1836481 ttgatgattt caaggcttaa aaaagaaaat aaactgagga ggagtcccaa atgaagatta 1836541 ccaatcccgt acttaaagga ttcaatcccg atccaagtat ttgtagagca ggagaggatt 1836601 attatatcgc tgtatctaca tttgagtggt ttccgggagt ccagatacac cactcaaaag 1836661 atttagtaaa ttggcactta gttgcacatc cattacagag agtttcacaa ttagacatga 1836721 aaggaaaccc aaattcaggt ggagtttggg caccatgttt aagctatagt gatgggaagt 1836781 tttggctgat ctatacggat gttaaggtag tagatggcgc atggaaagat tgtcacaatt 1836841 atttagttac ttgtgaaacg attaatggtg attggagtga gccgattaaa ttaaatagct 1836901 cggggtttga tgcttctttg ttccatgata cggatggaaa aaagtattta ttaaatatgt 1836961 tatgggatca ccgtattgat cggcactcat ttggaggaat tgttatacag gaatattctg 1837021 ataaagagca aaaattaatc ggtaaaccaa aagttatatt tgaaggaact gatagaaaac 1837081 tgacagaagc tccgcatctt tatcatatcg ggaactatta ttatttatta actgcagaag 1837141 gaggaacacg gtacgaacat gctgctacaa ttgctcgttc tgcaaatatt gaggggccat 1837201 atgaagttca tcccgataat ccaattttaa cgtcatggca tgacccagga aatccattgc 1837261 aaaaatgtgg tcatgcatcc attgttcaaa cacatacaga tgagtggtat ttagctcatt 1837321 taacgggacg tcctattcat cctgacgatg attcaatttt tcagcagaga ggatactgtc 1837381 ctttgggcag agaaacagct attcaaaaac tttactggaa agatgaatgg ccctatgtag 1837441 taggtggaaa agaaggaagc ttggaggtag atgcaccttc tatacccgaa acaatatttg 1837501 aagcaacgta cccggaagtt gatgaatttg aggattcaac attaaatata aattttcaaa 1837561 ctttaaggat tccattcacg aatgaattag gttcattgac tcaagcgcca aatcatttac 1837621 gattattcgg tcatgaatca ttgacctcga catttactca ggcatttgta gccagacgct 1837681 ggcaaagtct ccattttgaa gccgaaactg ctgttgagtt ttatccggaa aattttcaac 1837741 aagccgctgg gttggtgaat tactacaata cagagaactg gacggctctt caagtcacgc 1837801 atgatgaaga acttgggcgc attcttgaat taacaatatg tgacaacttt tctttttcac 1837861 agccattaaa taataaaatt gttattcctc gtgaagtaaa gtatgtatat ttaagagtaa 1837921 atattgaaaa ggacaaatat tattatttct attcttttaa caaagaagat tggcacaaaa 1837981 ttgacattgc actggaatcg aaaaaattat cagatgatta tatccgtggg ggaggattct 1838041 tcacaggggc ctttgtaggg atgcaatgcc aagataccag tggtaatcat attccggccg 1838101 actttagata ttttcgttat aaagaaaaat aatttgcaca tgaaaaagga gatttctatt 1838161 ttagaactcc tttttcatat gagaaggtgc catgtcacta ttgcttcaga aatactccta 1838221 gaataaaaaa actcatcttt aaagatgagc tgtccattcc ataaaaaatt acattgtaat 1838281 catgtccaga aaatgatcaa tcacaatgga ggacattcct aatgccggtg cattctgtcc 1838341 taaggaagat ggcaataatt catagctatt gcctaattgg gaataaaccc ttgatgatac 1838401 ttcacttctc attgaattta aaaccatagg atgcgattca attatgctat ttcttaaaat 1838461 tacggcttgt gggttgaaag tatttagaat attggtaagg cctattccta aatagaatcc 1838521 aaaattttgt aatgcattta aggttccgat atcattcaga tgggcgaggt ttatgatatc 1838581 ttgataggac agttttttct ctttggtctg aagagatttt aataaagcct tctctgaagc 1838641 atacaattcc cagcatcctc ggtttccgca actgcattta ggaccattaa agtctattgt 1838701 catatgtccc atttctccag agaagccgct tactcctcta tataaatgat tgttgataat 1838761 aacaccgatc cctattcctg tgctgatact tacgtaaata atgttatcgt gattttttgc 1838821 agctccaaat actttttctc catatgcgcc agcatttgcc tcattttcaa taaaaacagg 1838881 cacattgtac ttctcttgta tcgaagattt taagtcaata tctctccagt tggagttcgg 1838941 agtgaaaaca attttttgat ctttatcaat gagtccaggc acgcaaatac ctataccaat 1839001 aagcccgtac ggagattggg gcatttgcgt aataaagtga tgaatcatat caatcaaaat 1839061 gtctttcgtt atttctggag aattggattc caaatggcgg tattgatcaa gaacgattgt 1839121 tccttcaagg tctgttaaaa tgccattaat ataatccaca ccaacatcta ttccaacgga 1839181 gtatcctgcc tttttattaa aaacaagcat gacaggtctt cttccgccac ttgattgtcc 1839241 ttgacctatt tcaaatacca tactttcttt cattaacgtg tttacctgtg atgagacagt 1839301 tgatttattt aatccagtca tttcagataa ttttgctctt gaaataggtg aatttttaag 1839361 gatttctttt aataataact tttgatttac ttttttgaca aaggtttgat cagcgatatc 1839421 cacttcatcc actccatttg tttaatcttt aaattaagta tcaacatagt acatagcgaa 1839481 tcttcccttt attatatcta atgtgttcat aaaaaactaa aaaaaatatt gaaaatactg 1839541 acgaggttat ataagatgaa aataagttag tttgtttaaa caacaaacta ataggtgatg 1839601 tacttactat atgaaataaa atgcatctgt atttgaatga atttattttt aagggggaaa 1839661 tcacatggct caatctcatt ccagttcaat caactatttt ggaagcgcaa acaaagtggt 1839721 ttacgaaggg aaagattcga ctaatccttt agcatttaaa tattataatc ctcaagaagt 1839781 aatcggcgga aaaacgctga aagagcattt gcgattttct attgcctatt ggcatacatt 1839841 tactgctgat ggtacagacg tttttggagc agctacgatg caaagaccat gggatcacta 1839901 taaaggcatg gatctagcga agatgagagt agaagcagca tttgagatgt ttgaaaaact 1839961 agatgcacca ttctttgctt ttcatgaccg ggatattgca ccagaaggca gtacgctaaa 1840021 agagacaaac caaaatttag atatgatcat gggcatgatt aaagattaca tgagaaatag 1840081 cggcgttaag ctattatgga atacagcaaa catgtttacg aatccccgtt tcgtccatgg 1840141 tgccgcgact tcttgcaatg cagatgtgtt tgcgtatgct gcagcacaag tgaaaaaagg 1840201 gttagaaaca gcaaaagagc ttggcgctga gaactatgta ttttggggcg gccgtgaagg 1840261 atatgaaaca ttgttaaata ccgatttaaa atttgagctt gataatttgg ctagatttat 1840321 gcatatggca gtggattatg cgaaggaaat cgggtacaca gggcagtttt tgattgagcc 1840381 aaaaccaaaa gagccgacca cccatcaata cgatacagat gcagcaacaa ccattgcctt 1840441 tttgaagcaa tatggcttag acaatcattt taaattaaat cttgaagcca atcatgccac 1840501 attagccggg catacattcg aacatgaatt acgcatggca agagtacatg gtctgcttgg 1840561 ctctgttgac gcaaaccagg gtcatcctct tttaggctgg gacacggatg aatttccgac 1840621 ggatttatat tctacgacat tagcaatgta cgaaatcctg caaaatggcg gccttggaag 1840681 cggcggatta aactttgacg cgaaggtcag aagatcttct ttcgagcctg atgatctaat 1840741 atatgcccat attgcaggga tggatgcatt tgcaagagga ttgaaagttg cccacaaatt 1840801 aatcgaagat cgtgtgtttg aagatgtgat tcaacatcgt taccgcagct ttactgaagg 1840861 gattggtctt gaaattatag aaggaagagc taatttccac acacttgagc aatatgcgct 1840921 aaatcataaa tcaattaaaa acgaatctgg aagacaggag aaattaaaag cgatattgaa 1840981 ccaatacatt ttagaagtat aacaggataa gctccagatc ctgctatcaa taccaagtca 1841041 ctgaattacc cgtcatgatt cctttcctat tgcttgttgt tatgacgggt aacttctata 1841101 attaggattt atttagagtg aatggttttt taaaagggca aggagtgaaa aaatgaagta 1841161 tgtcattgga atagatcttg gaacgagtgc tgttaaaacc attttagtta accaaaacgg 1841221 caaggtttgt gcagaaacgt ccaaaaggta tccgctcatc caagagaagg cgggatatag 1841281 tgagcaaaat cctgaagact gggttcagca aacaattgaa gcattggctg aattggtttc 1841341 tatatccaat gttcaagcca aggatattga cgggataagc tattcgggac aaatgcatgg 1841401 attagtactg cttgaccaag atcgtcaggt gttacgtaat gcaattcttt ggaatgatac 1841461 cagaacaacg cctcaatgta taaggatgac cgagaaattt ggcgatcatc ttcttgacat 1841521 cacaaaaaac cgtgttttag aagggtttac attacctaaa atgttatggg taaaggaaca 1841581 tgaacctgaa ctttttaaaa aaactgctgt gtttttgctt ccgaaagact acgtgcgatt 1841641 ccgtatgacc ggtgtcattc acaccgaata ctccgatgca gcaggaactt tacttttaca 1841701 tattactcgc aaggagtgga gcaatgatat ttgcaatcaa attggtattt ctgcagatat 1841761 ttgtcctccg cttgttgaat ctcatgattg tgtaggatcg ctgcttccgc acgttgccgc 1841821 gaagaccggg ctattagaaa aaacaaaagt gtacgctggg ggagcagata atgcttgcgg 1841881 cgctattgga gcaggtatcc tttcttccgg aaaaacatta tgcagtattg ggacgtcagg 1841941 ggtcatactt tcctacgaag aagaaaaaga aagagacttt aaagggaaag tccacttttt 1842001 taatcatgga aaaaaggatt ctttttatac gatgggcgtc acgctcgctg caggatacag 1842061 cttggactgg tttaaaagaa cgtttgcacc aaacgaatcg tttgagcaat tattgcaggg 1842121 ggtggaagct attccgatag gagccaatgg actgctatac actccttatt tggttggtga 1842181 aagaacgccg catgctgatt cttctattcg gggaagcttg atcggaatgg atggagccca 1842241 taatagaaag cattttttga gggcaataat ggaaggtatc acattctctt tacatgaatc 1842301 aattgagcta ttccgcgaag cgggaaaatc agttcatact gttgtttcta ttggtggggg 1842361 agctaaaaat gatacgtggc tgcaaatgca agctgatatt ttcaatacga gggtaattaa 1842421 gttagaaaat gaacaagggc cagctatggg ggctgcaatg ctggctgcct ttggaagcgg 1842481 ttggtttgaa tcacttgaag aatgtgcaga gcagttcatt cgtgaggctg ctgcatttta 1842541 tccaaaggcg caaaatgttc aaaaatataa aacactattt gatttgtata agaacattta 1842601 cactcacaca aaggatctca atacagcttt gaagagcttt cgaaaaaact aatgatgtta 1842661 ttgtctggag atcaaccgaa gaacaattaa tgatcaatca tcatcaaagg cctttgataa 1842721 catggctgcc ttcttttgaa aagatggtga gaataaggta tcgcaacctt taaacagtat 1842781 tggagtatcc agcagacaaa acgaacgagt ggaaccgtat tttgtcagcg aacacttcaa 1842841 gaagtgggga agcttaggaa tgccaatggg taagatgtat gaaaccgcgc taacgacggt 1842901 agagggatct cttgatttat gaagaaatag gaaggatgtt aacacacaaa taacccctca 1842961 cattgacgtg aaggggtgtt ttttattgtt actatacagc ggaaatttta caggctagtt 1843021 gcatgatttt agcttgttaa gcagaatgga actagactct ccatcatctc tttctcattc 1843081 tttggaaact gcattctgct aggtttgctg ctttttttaa caaacagtgt ttttctattt 1843141 cacacagcca ttaaatcctc tgttcgtcac ataaccgctc ttactccaaa ttgacagttt 1843201 atctgatttt gcttcttgct catctagtct gaattggtct atgtattttg tgttaggctc 1843261 atatacatat gctactctgg ccaatccctc tttcaataat gtctcttgaa cagatttgcc 1843321 gtcaacataa acgtatgcta acagtcttcc atacttatct ctgcgatcgc ctttatcaaa 1843381 ttccagctgt agcttaccgc tgttgaccaa ttctttattt cgtttcgacg catcctcacc 1843441 gtatggttga acacaagaat ttggtttctt cgtctcaggt gtatcaacga gcaagtagcg 1843501 aactgtgtct ttctttccgt tgtaaataac cttaatcgta tctccatcta ttgctctatc 1843561 taatgtaaca ttgaccaatt tcttctgatt ttttgaatga ggcgtgccag ccttttgttc 1843621 tgtctgatta tattcattag agtgagtatc ttgagagact tgctccgtcc cattagaatc 1843681 tgaatggttt ttggctgcgt gatttgatcc gcaagctgcc aaagtaatac ttaaaacgat 1843741 tgcgatcata ctgatcaaaa tcttcttcat attgattccc tctttatcat tttctctttt 1843801 cgcgattaaa catcatcatt ataacgatat ggacattttt tgtgaatgga aaacttcaag 1843861 ggaacttata acactccaaa ttgccaatag ttaacttcac aacgagatga tcaaaacatc 1843921 accatcacat agcggaaata aataatcctg aaaataatat tgactgaaaa tgcttttaga 1843981 attatgataa tatgagaaat gacaataatg tgacaaagac attactacaa cataacaact 1844041 aatagcttag gtttattcta ttggttaaaa atgtaaacgg ttacaaatcc agaggcgaaa 1844101 atctaagata gagatgactt tagttttgac tcaatatcca cactgaaaga gcttattaag 1844161 tattcttaaa ggcaggggaa atggatatga atgaacatcg aaatcgaagg ttgaaattaa 1844221 taatgatttc agcaactttt ggagggcttc tctttggata tgacaccgga gttataaatg 1844281 gagctttacc ttttatggca aggccagatc agcttgattt aacacctgtt acagaagggc 1844341 ttgttacgag tattctttta ttaggtgccg cgtttggagc gttgttatgc ggaagattgg 1844401 ctgatcgata tggccgccgt aaaatgatcc ttaatctttc ctttttattt ttcctggcat 1844461 cactgggaac agcgttagca cctaatgttt tcatcatggc ggtctttcgt tttttactgg 1844521 ggctggctgt tggaggagcc tcggcgatgg tgccggcctt tttagcagaa atggcaccgc 1844581 atgaaaagag agggcgtatg gtaacccaaa atgaactaat gattgttggc gggcaatttt 1844641 tagcatatgt ttttaatgcg atcctcggtg taacaatggc aaatacggga catgtttgga 1844701 gatacatgct agtcatttgt gctgtaccgg ctatcatgtt atttgccagt atgcttaagg 1844761 taccagaaag cccccgatgg ctaatctcca aaggcaaaaa cagtgaggcg ctgcgagttc 1844821 ttaaacaaat tcgagaagat aaacgtgcag aagctgaatg tagagaaatt caagaagcgg 1844881 tagaaaaaga tacagcacta gaaaaggcat cactcaagga cttttctaca ccatggctgc 1844941 gccgtctttt atggattgga atcggtgttg ccatcgtgaa tcaaattaca ggtgtgaact 1845001 cgattatgta ttatggcaca caaatcctta aagaatctgg ttttggtaca aaagcggctt 1845061 taatcgctaa tattggaaat gggctgatat cagttattgc agttatattt gggatttggc 1845121 tggtcggaaa agtgagacgg cgtccaatat tattgattgg tttggcaggg acgactacag 1845181 cgctcctatt gattgcgatt ttctcaattg tgcttgatgg atctatggca cttccttatg 1845241 tagtgctttc tttgaccgtt ttatttcttg cctttatgca agggtgtgta ggacctgtga 1845301 cttggcttgt catagcggaa atattccctc aaaggttaag aggacttggt tctgggataa 1845361 gtgttttttt cctttggata ttaaactttg tgatcggttt tgctttcccg atcttgctta 1845421 gctctgtagg tttgtctttt acattcttta tatttgtggc tttaggtgta ttggcaatcg 1845481 gttttgtgta caaattcatg ccggaaacaa aagggcgtac acttgaagaa ttagaagagc 1845541 attttcgttc tcgacacgat cataatactc ctgaacaatc agttattgag gtataaatat 1845601 gttgaaaatc tctcttctta taggagggat ttttttagtt tcagaaaaaa caaaatccct 1845661 ctggtagagg gattttgatt cagcatttta agatgttcta cacgtataat actggagttg 1845721 atactttaaa aatctcgcca tctcttatat aaaaacgagg gatgcggcgg cttaatgtag 1845781 acacgacttc atagttaatc gtattgagca tttcagccac ttcatcaacg gaaatctcgg 1845841 ctcctttttg cttaccgtaa atcacgactt catctccttg tttaccttca ccgttttctc 1845901 ctaaactgac catgatcata tccattgtta ctcttcccgc cactggcact cgttttccgc 1845961 gatgaagaac aaacccgcga ttggaaaggg cacgagaata gccgtcagca tagccaatcg 1846021 ggagtgtagc aattacttca ttaggttctg cgatgtatgt agcaccatag ctaacggttc 1846081 ggggttctgt ccgcatggtt ttcacataag cgatgcgtgc ctttaaactt aacgcaggtt 1846141 caagcttaac gagatttagt tgtttaatat aggctgaagg atataaacca tataagccga 1846201 tacctaaacg gatcatatca gcgctaaatt ccggaaatgc gatagctgca gccgtgttgc 1846261 acatatgcac ggtgggcagc tcaatcccct gtttttttaa aaagctgaga aaactgatga 1846321 atttttcatg ctgcagcttt gtgagtgttg tgtccggttc atcagctgtc gaaaaatgtg 1846381 tgaaaatccc tgtccatctg aggaatttac ttgcctttaa ggctttcact acctctaaaa 1846441 gttcttcctt tgtgcgtaca cctaatcgtc ccatgccggt atccacgtta atatgaatgg 1846501 ccagccggtt agcactcgct tctttttcca atatctcgtt tgcttctttc atccaatcaa 1846561 cctgaaatgc tgataatgtt atattccaag ctgctgactt ctttacacaa ctaagggatg 1846621 taaaaccaag cacaaggata ggtgctgtaa tcccagcttt acgtaaaacg attccttcct 1846681 ccacactggc aacagcgagc tcactcgccc cgtgttccag tgcatggcgt gccacttcta 1846741 tagacccgtg gccataaccg ttcgctttta caacagccat aattttgctc ttatgtggaa 1846801 tatgacggcg gatcgctcgc aaattctttt taacggcatc aagattgact tcgatccaaa 1846861 cttctcggca aagctttatc atcaacgctt ccttccttct tatggattat aaataccacc 1846921 tattgccgca agaataaatg ttaattgttg gatgattcga tcttatttta ttcaacttta 1846981 tttgaaatca ttcaacagca aatccatgtg atacgagaag gtgcctatca atgttcgaat 1847041 aatagcaagt acgggataca tgaggcttgt aagtggggtg ttaatggatg cggcgaccga 1847101 ggattacaaa aatgattatt tgttttggga catttttttc taagggtaga tgataacgag 1847161 aaatctaatc aggaaatact taccgttgtt atgaacattg aagaaccttt taaatgagaa 1847221 gggctgagga aattctgtaa aagataatcg gttgaaaagg cagtcgattc cttgttccat 1847281 aaacctaaca tcagagtata taattatact cgtattcaca aaaatcgttt aagtaagggg 1847341 tatacatgaa taggggagtt agttttcaaa taccgaatga atatggaaat tttctatgga 1847401 gaatactgca gccggtagaa atagctaatt ataggtggca aacgagtggg gaatcttatt 1847461 ttgttgtaga aggagagctc gatgatgagg agctttttca tgactacgaa attgttgagg 1847521 gggcagtttt tgagcaacaa ttaaaaacga atcagtacta taccattttc gttgaactga 1847581 aagcatttcc atatggaaaa atggttaatc aagtcaatac atatgaagag tttgctgaca 1847641 gtgattgcga acttgtcctt ttgatagcag ataatagcta cgtttcgatt tactgtaaaa 1847701 acaaaaatat cattgaaaaa ctttacttca atgctttaca gcatgatttt gaagacgttc 1847761 aatttataac tgatgaaaat gacacaagaa caagccttac tgtatgatac tcaataaaaa 1847821 ttaaaggagc tagtacatga caatgcaaat taaaatcaag tatctagatg aaacacaaac 1847881 aagaatcagc aaaattgagc agggagactg gattgatctt cgggcagctg aagatgtaac 1847941 aatcaaaaaa gatgaattta agcttgtccc attaggtgtt gcaatggagc tgcctgaagg 1848001 ttacgaagca catgtcgtcc ctcgttcaag tacatataag aactttggcg ttattcaaac 1848061 aaattcaatg ggtgttatcg atgagtcata taagggagac aacgatttct ggttctttcc 1848121 tgcttatgca ttgcgtgata ctgaaattaa gaagggtgat cgtatctgcc agtttagaat 1848181 catgaagaaa atgccggcgg ttgaattggt tgaagtcgag catttgggaa acgaggatag 1848241 aggaggactc ggttcaacag gtacgaagta aacaaaataa atccttggct gtcttcatgc 1848301 tgtgtgattg atcaatggag gtttcagcca aggtacatat aaatattatg tataaaatga 1848361 atattttaat acgaaggatt taattaaaaa caaagtttaa aaagggaagt tttgaaaaag 1848421 tgaaatagta ataactaaag tcgataaaga acctaaagat gtcaaagaaa caatttttct 1848481 ggtgctttgc ttttttgaag gtttacttag ctcgtggata actgcccccc ataaaagcat 1848541 ggatgctaaa attataatac ttatatacat aaagatgctc cttttattat atttacagtt 1848601 tttacatttt tatcgatttt accacattta ggattgagtt gtcgatgaaa caagcatctc 1848661 tataaagaaa tacttttatc taaattttta taaatagggg aaggcaacta aaaactagta 1848721 atgccactaa taataagcca agttaaatga cttgtgttca ttaataattg aattttacag 1848781 cagccatgag cacaaaaaaa tctgagttcg tcgataaata tcataaaaaa gcccccggta 1848841 tgtcgccagg gaataaatag acgtttaaga gatttagtga tgttttttat atgattcgac 1848901 aaaatcataa taatgatcat cgtcatcata atactttttt tcgtaatgat aatcgtgatc 1848961 atcgtaatac tttttatcat ggtcatcata ctttttgtcg taatcataat gttttttatc 1849021 atgatcataa tacttgtcgc aatcataatg cttcttatca ttgtcgtaat actttttgta 1849081 atatgttttt ttccaagtat aatactcttc tttatatttt ttataataac ccaattaaat 1849141 tcctccttta tgttattcga atttaattta tgaagtttaa atgatatggt atggtcaaat 1849201 gaaataagaa tagtaaaaag aggctgttta aaacactttc tgaaaaacaa aacggatagc 1849261 tgtttatgaa aataagagcg agagagagca ctcaatcact gtaaaataat agtaaagtgt 1849321 atagagagat tagtatacgt aaaaagggac tttctcattg aagaatattt gaacgttatg 1849381 gttaagattc aagagctcta tgatgtgatt tttcacactg cttttgaagg atttagagtt 1849441 agacatcaaa aacaaacagc aaaaccggct agaaacagat catataagga atgaaccgct 1849501 gccaaatatc ataaaaaagt tgttaatgat caaatgaatg aaattagaga gaatttattt 1849561 taaagaaagc ccaattgcac atggacaaat gacaattgat attgaggtaa aatacaatgc 1849621 attaaatcag aaaaagctat tggaggattt aatgtgttta gacaatttcc aatttggtat 1849681 acacaaacac ctgactattt gaatttttat gtaccgcaat atcaaaccat ttcgtataat 1849741 cctcaacaat gttatcaacg gtgtatgtac caaactggcg gtaactatga gctatgtgac 1849801 agactatgtt atggagaaat acaggtgtaa aagaggggga ttaactcctc tttaaacaca 1849861 cagtgagtgg aataagatcc tcactttatc tgcaagtgct tagtatttgc gataatattg 1849921 cattcgtaat aaattatgct tagcaactga aaatgaaaga aggatatgaa tagtcatgac 1849981 gcaattcgat aaacaataca attcaattat aaaggatatt atcaataatg gaatctcaga 1850041 cgaagagttt gatgtaagaa ccaagtggga ctcagatgga acaccggcac atactctaag 1850101 tgtaatcagt aagcaaatga gattcgacaa ctcagaggtt ccgattttaa cgacaaaaaa 1850161 ggttgcctgg aaaacagcca ttaaagagtt gctctggatt tggcagctga aatctaatga 1850221 tgttaatgat ttaaacatga tgggcgtcca tatttgggat cagtggaaac aagaagacgg 1850281 aaccatcgga catgcatatg gatttcagct ggggaagaaa aacagaagtc taaatggaga 1850341 aaaagtggat caggtagact atcttcttca tcaattgaag aacaatccat cttcacgcag 1850401 acacattaca atgctgtgga atcctgatga attagacgca atggccttaa cgccatgtgt 1850461 atacgagaca caatggtacg ttaaacatgg gaaactccac cttgaggtaa gagcacggag 1850521 caatgatatg gcattgggaa atccattcaa tgtattccag tataatgtgt tgcagcgcat 1850581 gattgctcaa gtgactggtt atgagcttgg tgaatatatc tttaacattg gggattgcca 1850641 tgtgtacaca cgtcatatag acaatttgaa aattcaaatg gaaagagaac agtttgaagc 1850701 acctgaacta tggatcaatc ctgaagtgaa agatttttat gactttacca ttgatgattt 1850761 caagttaatc aactataaac atggggacaa gcttttattt gaggtagcgg tttaatgctg 1850821 cctttttatt gtgcagtgaa tagatagcag gtatcctaat ttcattaagc aatctggaag 1850881 atgaataaaa attgaaggac aaacacgtat aatacataaa aaagattaac tctacagtta 1850941 atctttttta ttcagaagaa aatatcctaa ctttgaaact aaatacaaag taaaagcaat 1851001 cattacagtt ctagatatta caattccatg aatagctaga tcatatccag caggtatcaa 1851061 cgcatttgta ttacacataa aatatataga tattagaagt gctacaataa ctaaaatcat 1851121 tccaaaaaga cttgtttttt catatttcat accaatttcc acccttatta aagttaggtt 1851181 taaacaaaag agctgaagaa acgaactatg accagtatgc tccaaggaaa accgccagac 1851241 aatgctggcg gctttttgct gcttcgttta tttattaaca gagatcgtaa cgttatttcc 1851301 tgcaactgaa acctttgcga aatcctgtgt atctaccaca ggagtgacgg ctttattgtc 1851361 gatagtgatg ttgttaaaag aggtcgaaaa ggttgctttg atcgcatcac gctggctttc 1851421 atacgaaaca gccgcggtag caagtgtttt ccattttgaa atcgtgccga tgttggttcc 1851481 ttgaatttct gtgataatcc gtccggtgta gccgtcattg ttcgttcccc aaagggtcat 1851541 gcgcgtattg ccgcttaaat ttttatagat tgtcatttgg actgtgcttc cagggcggaa 1851601 gcctttattg tatgtgaatt tgtcttttcc ttcgatgtac gtttcttcat ttttggaccc 1851661 aaccttcatg aggggcttcc agacgttgta ttgtttgctg tactgaagcc cgatatcggc 1851721 ttcagttccg cttgttgccc taaagccaga ataaatatag ggagtagaga ccgagtcgtt 1851781 gtttttgaca gtttcaggaa gcacgatttt agctgtaaaa acggcgcccg tactgttcag 1851841 gtagacacgg ccgccgattc cgttaggcag ctcggatgct gcttttgcga cttgagcgtc 1851901 tgccgcgggt aaacctggta tacctgatga aagggttccg aaaagaactg ctgttcctac 1851961 tgcacctgca atcaatactt ttttcaccaa aattccccct tttgatagtg gtttcgccat 1852021 ttattatacc ttattttgga actggattta cgtatataaa tcgacaaaat atttcatttt 1852081 gaatgatgta aggtcgaaac gcttcgccaa tctgaaagct atataccttt atcagaggaa 1852141 agaatgagat cacattcgtt ttaaccgatt tgaaattttc ctcaaaataa aagtacaaat 1852201 gcttaaagaa acgattatta aaagaatgcc cgctatcgtt tccaagcctg taaaaaagag 1852261 gtgacgtttc atcaatgtct gtccttgtaa aatgataaaa gcacagatac cgactaagaa 1852321 aagaaaacaa atacttagga ttgctaacgc tttacgtgag tatgttttca tttcatcttt 1852381 aaaatacagc aatacgaaaa taaagcagat aacattggct attgttctaa tcacctcaaa 1852441 gcttttcatg acaactgata taaatagaca aagtaaaatg agataaaata cgatgtttct 1852501 atacaaaaaa cctctccttt tatgtaggat cctcaaagag tttataaaag tttctttgta 1852561 actgcaataa attgaatgcg ctcacttatg aactaactaa actatgtact aaatattcac 1852621 tattcttttt cagattcagt caccaaggtt ttcatagaaa gggaagcttc agaaatatac 1852681 atatagtgca caaacaaaaa agacccggca atagccgggg gaaagtaaaa acgaggagat 1852741 gttaatggcg tttagtagtg ttttttatgc tttttatact ctacaacata atcatagtct 1852801 tttttatcgt gatcataata ttttttatca tagtcatcat attttttgtc gtaatcacag 1852861 tcataatctt ttttatcata ttcgtaatac ttcttataat acgttttttt gaccgtataa 1852921 tactcttctt tgtatttttt gtaataaccc atatatactc ctcctttatt tttactacgc 1852981 tttattatac ggcgagtaga ttttgcggct tggacagtta aaatcataga aggaaaaaag 1853041 ggctgtccaa atgatagaaa aagacagatg acacaaaaac aaatcaaaat aaagagccga 1853101 tttttcatcg gcccaaacga tttatcctac atttgtttgt cttctttgtt ttctgagtca 1853161 ttttttctga tatcctgagt cagtccgctt gttgcttgtt taaattctga taaggctttt 1853221 cctgctgcac ggccaagcgc cggcagttta tcaggcccaa atactaaaaa acccacaaac 1853281 aaaataacga gtatttttgt gaagcttaat tccatatcct tttccccctg attgaagtac 1853341 aaccttttaa acaaattata agagatagca gtacaaatgg gaatgcattt attttgaaca 1853401 ttttaaaacc agcacaaaga cggattcata aaacggctgc tgctgaatat aatgtccaat 1853461 gccacctgcc taagaagcag gaggcaggct ggatcaatta tgtagctctg ccggaaatga 1853521 tacaaacgta gcggctatca ttgacataga ggagtggtgt agctgatgag attcactaag 1853581 gtagttggat ttttgtctgt tttagggttg gctgcggttt ttccattaac ggcacaagca 1853641 gaaaaagccg gaactgcggg ggctggagag tgggataagt tggggactta cacatatact 1853701 tactcaagtc cgacggtata ctcgaccgga ggagatttta gagtgtgcct ttcaggaagc 1853761 actccttttt ctgtttcact gcacttatat gaggatgatc ccggtgacaa tcctgatgat 1853821 tatgtagggg caaactattt ttcacccgga gaatgccaca cctttggcag tattggaaaa 1853881 tttgtagatg ggagcaataa caaggccgag ttctttgtta ccgattactc tggtaaatct 1853941 aaaactgtta cgttttatga ttgatggact caaattgtga agtataaccc ttggaaaaaa 1854001 acaaaaaaga gagatacctc tctctttttt attcttcgac agccttacga agccgttcat 1854061 ttacaatgcc agtccagccg ccatccatct taccgcgaac gacggagctt ttctcgtttg 1854121 ctttgccgat cacttcattc ggctctttcc agccgctgtg aataagggta aaccctgtct 1854181 tttcccccaa gtcttctaat tgaaaggtaa cgacccatcc ttctgtatcc cattcaaaag 1854241 aaagttcagt tggagcttga acagccaaaa ctttacaagg ggacggccca aacggcgatt 1854301 gtaagtgaaa ttcttgtcct tctttgagct gaaagtcatt gggcataaac cacttggcaa 1854361 tgccttctga agtagagact gtctcccaga ctttctgaat gggagcctcc agagtaatgc 1854421 tttttgtaat atccggtaat gcattttcgt tgttttgagc catttcgttt acctcttgac 1854481 atatgatgtt ttttcaattc aatcatataa taactaataa gatcatgtcc atagcgtgca 1854541 ttatttatgc tagagctgct gttgaacagc gtgtcagtcg ccagtctgat ctgtgaatgg 1854601 gagaattctg catgcgcgaa aaagagagag aggtgtatgt tgtcatttcg ttcattcttg 1854661 tttgcagccg caactgttat gtttgaactg ggattcctgt tcagccaatt tattttgcga 1854721 tttttgtttt aatagtaaat gagccatttt ctaaaacagg aggtttttta tgcttggaaa 1854781 aatcaaagca gccattgata atagtccagg gaagccggcc agaattttag ttagtgaaaa 1854841 agcgtttcag caattagagg aagaaatgcg ctttgtttac gtttccaaac cgaaaacgat 1854901 aatggggatt cctgtggaag tttcagatca ggcagaaagc ttcaagctgg aattttagtt 1854961 ttcccagact gctaaaaggc tcattttgtg ttaattatgc aaaatggtca ggttgatttc 1855021 tttaaaagca tgatgaaatg ttcatcatgc ttttttattg agaaaaaaga cgaacataaa 1855081 aaataggtat acgggaaaaa taatcctatt agagagaggg gaactgacag atggataaca 1855141 tgatatcaac acttactgac tggaatgtgt ggtttcaagc gttagtagta tttctcgttc 1855201 catatgtaat ctataaagtg tttacttgga ttcatgtata agaaggtgca atgatgaggt 1855261 ggcggaacaa tcagtacaaa acacagaagc agcataaatc agattattcg acagctgaaa 1855321 agcaggatca ggatgtgtta accggtaaca tcggatacga cttagaacat gtaaaaagaa 1855381 aaataggaca taacggggac gttcatttcc gtgagcttga aatcactcaa ttacatgtga 1855441 aagcggcatt gatctttgtt gaaggactgt ctgatcagga cttgattaat aaaggactat 1855501 cagtgttagt catgaatcaa cctaatcagg taagcgatga aatttctcaa tccggcaaag 1855561 gtattttaac ttcgaaacag ataaaaaatc aaatcgtatc aatcggtgat gtcatagatt 1855621 cagagaaaat cagtgatatc gtgttgaatg ttttcatggg ttcgacagcg cttctcatcg 1855681 atggaatacc gcaggccttt cttctgggaa ctgtaaaaaa acaaaatcga agtatcgagg 1855741 agccgctttc agaagcgctt gtcagagggc cgcgcacagg ctttacagaa gagttgagta 1855801 cgaatacagc tcttttgaga cagcaaggaa aaaatgatca attaacattg cagagatttg 1855861 aagtaggaac acgattaaaa aaggatttaa ttatcgctta tatgaatgac attgcagatc 1855921 caaaagtagt cgaggaagta agaaaaagag tgagagggat tgagatcgat catttgccgg 1855981 agtcaggcta cgttgaacag ttaattgagg ataattattt gagcccgttc ccgcaagtac 1856041 agagtacaga acgtcctgat cgcgtcataa gcggattaat ggaaggaaga gtagctattc 1856101 tgcttgacgg cactccgttt gctttgattg ttccagtcac tttcagcatg atgcttcaat 1856161 cgcctgaaga ttattatgaa cggtggttcc cgagctcgct catcagattg ctgaggttca 1856221 tcgcagcaat gataacgtta ttcgcacccg ctttatatat atcatttatt tcttttcatc 1856281 ctgggttaat tccgaccaag ctggcgattt caatttccgg gacgcgccaa ggtgttccgt 1856341 tcccatctct gattgaagcc ttatttatgg aagtcgcgat tgaaatttta agagaggcgg 1856401 ggcttcgttt gccaaaacca attggacccg caataggcat agttggcgga ttaatcatcg 1856461 gggaagcagc tgtgcaggcg gggattgtca gtccaatcat ggtcattgtt gttgcgctca 1856521 cagcaatttc ttcatttgcc atcccgcatt atagcacagg tatagcactt cggatgcttc 1856581 ggtttggcgc gatgttttgt gcggcggtgt ttggattgtt tggagtcatt atgtattatc 1856641 tgctgctaag cagccatgtc gtaaagctaa agagctttgg tgtgccatac gcaagtccgg 1856701 cagtgcccta tcacttaaaa gattggaaag actttgttat cagaatgcct cttttagtca 1856761 tgaagcgccg gcctaaaatg atgaatacag ataatacaaa acgggtgaag tgatgaactc 1856821 gacaggatgg tgataaagtc tcatgttcag cccaaccagt aaaatcacaa ccgctcaggc 1856881 aacgattatc atcattaatt atatgcttgc tgccggagtt cttacgctcc ctcggacagt 1856941 aacagaacaa acacaatctc ctgatggatg gatttcagtt ttattaggcg gggtcctagc 1857001 ggtaatagcc gggatgatta tagctaaatt aagccagcag tatcctaagg agacctttta 1857061 tgaatactcc cgacatattg taggaaaatg gctcgggcat ctgatcagta ttgtttttat 1857121 tacttatttt ctggcactcg gtgcatttga agtcagagtc atgtccgaaa tcgtggattt 1857181 ttttctcctc gaagggacac cttcttgggc catcattatg acagttcttt ggattgggct 1857241 ttattcaatt acacaaggcc tagatccgat tgcacggctt tttgaaatga tttttccgat 1857301 tacggtcatc atctttttaa cgatagccct catgagttta ggcatatttg agatcaacaa 1857361 tttgcgccct gtattaggtg atggaatcat gccggttctt agaggtgtaa agacaacgaa 1857421 cctttcattt acatgttcag aaattatgtt cattttagta gcatttatga aaaagccgaa 1857481 aaatgcggtg aaagcagttg tgatcgggac aggcgttgtg accagttttt atatgattac 1857541 gatgattatg gtcatcggtg cactatcagt tgagggagtt gtgacgagaa catggccggg 1857601 gcttgacctg atgagaagtt ttgaaatacc tggtttaata tttgaacggt ttgaatcatt 1857661 tctgcttgtg atttggatta tgcagctttt tgccacgttt attatcactt tttatgcagc 1857721 ttccctggga gtctcacaag tttttaaaaa gaaacccctt tcatgtatgt ttgggctgct 1857781 tcctgttata tatatcctct cttgcatgcc gaaaaatgaa aatgacgtct ttatattggg 1857841 cgatacggtc agtcatatcg ctttgtatat atttggcgct ttgccgattt tgctgttagt 1857901 catttcgaaa tggaggaaaa gaggtgaaaa gtaaactaaa acgtcaattg cctgctatgg 1857961 tcatagtatg tctgctgatg atttgcgtaa caggatgctg gagcagtcgg gaaatagaag 1858021 atctgggtct cacattcgct atcgcaattg ataaaggaaa agaaacgaac actgaaaaag 1858081 agttaaaaga agagggcggg agctatccga aaaaagacaa cattacgctg acctatcaat 1858141 ttgttaatga aaaagcggca ggcgcgggca caagcggggg aggcggtagc ggacaaggag 1858201 cgcaaaaagc gtacattaat ataagtgaaa caggggattc attacagcag atcggaagtg 1858261 aggttgcatt aagacgggac cgagaagtgt ttagcccgca tttaaaagtt gttgtcatga 1858321 gtgaagatgt gctgcacaca tttcctatcg acgaaatgct ggatcaattt tttcgtgata 1858381 atgaaatcag gctgagctgt cttgttttat ctgctaaagg ggaagcaaga gacgctctcc 1858441 agctgaaaga gaacggagaa attccggcat ttcggctgat tggattaggt gaaaatgaac 1858501 ataaagtttc cagaattctt ccccctatga cactcgcgaa actaattgga aaactgcatt 1858561 ctggcagcag ctttttactg caaaatgtgg ttgcggcgaa tggagcggtc aagtattccg 1858621 gagcagctgt aatcaacgga aaatcgaaaa aaatgatagg caccttaaat gaatatgaaa 1858681 ctgaggggat tacatggatt agaggagaag ggaaaggcgg agttgtcaaa agtcatgata 1858741 aaaagagcca acagacgtta gcgtacgata tcaataaaat caaaagcaga attcagccaa 1858801 tcgtaaaagg gaaagatatt tcattccatg tcgatattga atcagaaggc gatttggttg 1858861 aaaactggaa cacaaaagag gcgttggaca cccagtttat agatcgtctc gaaacgacta 1858921 ttgaaaacga ggtaaagaaa atagttggtc aggtattaaa aaaaattcag catgattata 1858981 aagcagatgt tgcgggtttt gatgaatctt ttagacttac atatcctcac ttatggaaaa 1859041 gggtgaaaaa taactgggat gacaccttca gtaaagccga catcacatac agtgtgaacg 1859101 tcacaattac tcatttcggc acggttaaaa ctcagtaatg aatcccaagg aagagaagga 1859161 aacctctctt ctctttttta tgcatttatt aggataaaga tacttttttt ggagagatat 1859221 acacttttca aatcgaccaa tatgctaata taggaattgc ttgaaataga agggagaagg 1859281 ggctgtgagg cagaaaccga tttatgtaga aatcgaaatg aaatctgatc tggatacact 1859341 ctgggaatat acacaaaacc catcactgca taaggaatgg gatctccggt tttcaaatat 1859401 tacgtatttg aatagtcagc catgcgaaaa acagaagttt ctttacgaaa caagggtagg 1859461 ctttggatta aaggtgtcag gtacaggaga aaccgtcggt gttttcaaca aatgttcatc 1859521 tgaaaggtct tcttcactgg cttttggctc tgatcatcca ttatctctga ttcggcatgg 1859581 aagcggctac tggaagtata tacagagaga aaatgggaaa atgacgtttt taacacagta 1859641 ccaatacaaa acagcctacg gactgctggg aagatggatt gatcgtttat tatttcggcc 1859701 gctgcttggc tgggcgactg cctggagctt tgatgcatta aggctttggg tagagcaaaa 1859761 taaacatccg aagcgcttca ttcgatctgc tatcatctat gtgttcatgt gtctgttttt 1859821 cagcctgttt tggttctatc aaggctttgc aggtgttaag acaagcatat tgacaggaac 1859881 agcggagata ggcttagcta ttttgtggct gcttccttta aaaagaaaat ggatcattca 1859941 tggtgtccag gcttgtattt ttgctgggtt tgcttgtcta ggttccgaaa tattcatgtg 1860001 ggttctattg agtgtgtttt ccgctgcaag cggcgctctt agcctgcagc tccccagtgc 1860061 caggcgcaca aaacgaaaga gaaagaagtg acattgtgag ttcgatttat gaaaaatcaa 1860121 ttattaacta tcatttgctg catcccaagc tgcagaaacg gtaccaatta gacgggtctc 1860181 atacattcag cgggacggga acgatgtcag aaataagcgg aggctctttt ctggttagaa 1860241 tgctgttaaa gctgggtgtt tttttcagat gcttcttttc agaaagaggc aaagacattc 1860301 catttacaat acaaaataga acttgtcttt tgaaatcgca acatacagga atagaatgga 1860361 atcgtacatt tttctttaaa ggcaaaaaac gtttctttga tgcgttaatg atatatgacg 1860421 agaaagaaaa tagaatactt gatttcttcg gcaaacctca tctgctgctg tctgttttga 1860481 cgttcgaggc atctcttgac ggctctctta cgatcacatc gggaaagcaa tggctattga 1860541 tatgcggaaa aagaatcccg ctgccgaaat ggctgaccgg tacatccgaa gtttgcgaaa 1860601 cgtttgatga aaaaaagaat tgtttcacca ttgaagtgca tgtgcaaaat acaattcttg 1860661 gcactctttt cttttataag ggaacgtttc aggaggaaga gagagaatca tgaaacgaaa 1860721 tggcatagtc agtgcgcttt gttttattgg atttcttgca gcagaagcac cggatatttc 1860781 agtggcagag gcactcgttt tgttatccat tctatttttc gtgccgggaa tttttccttt 1860841 tgtttttcgt caatctccgg ttcgtgctgc tcagtttatg gaaaacgggc taatccagtg 1860901 ctatcctgta gccgcattct ttgcggtgct ggctctagtg acggaggttg ggggtttcgc 1860961 acttatctgg tggatgtaca cagtttttaa tgcattgtat gcgatcctcc gcctttggga 1861021 aacaaagata catagaatcg aagagacatc agttttgttc ggtcttattt atttggcggg 1861081 aggaggattt tggttttttg cttatgctgc ccatttgcag atcatgcaat ttggccctct 1861141 catcattttg ctgactgctg tccactttca ctattctgct tttctgatcc cgatcttcaa 1861201 cggtttactc ggcagaacca ttagaaaaca tcggatgttg tacagttgga taacatgggt 1861261 gattttgctt tcgccccttc ttatcgcact gggcatcaca tattcaaaaa cacttgatgt 1861321 cattgcggtt agcatttata tggcggcgat ttatcttcat gcatttttgg tgttcacggc 1861381 agcttttcgc accaagacgg ggacatttct tattcggctt tcttccgctg ttttaatgat 1861441 aacgattgct ttctcgatga tttattcatt tggtgtcttt cggcaagaag ttacattgac 1861501 catcaatcag atgatttgga ttcacggttt tgtcaacgcg tttggtgtta tcttgcccgc 1861561 tctcataggg tggagaatag aggatgcgaa accttttgat gcagacagtg taaagacatt 1861621 cagccgtatc tacggaaaaa gaaagattgg agaagaattt ttagctaaca ttcaagctga 1861681 aaataacgct cggtacagcg gacttgtgga tgatatgggc agcctgcgtt caaaagattt 1861741 ttcaccagaa aaactggcgc cgctcattct ttcgttttat gaacaaacca tcgaatacaa 1861801 tattaaagca aaagtaacat ggagcacgtg gtttcggccg cttgcaatta tttacgaatg 1861861 gttcagcaga agaatcggcc aaatacatct ttcgacgaac cctgactggt ataggatgta 1861921 cagcaagata aaaggtgttc attcgaaaaa agacggaagg gaaagagtac gtgcctggat 1861981 tagaacaaat gaaaaaaacg aaaccatttt taccgctctt tattcagtgt atcgttcaaa 1862041 tggagagggg tatatgaata tttctttacc gcttccattc agcagcatga caggtatttt 1862101 aaaaccatat catcatcagg agaagctggt tttaacaagc aggcggagaa aaagcagagc 1862161 gggggatgag gggatttatc tgcaaacaag agcgggaact tgtccgcttc ctttatctga 1862221 aacctttctg atagaagctg tacatgacaa caaattaacc gctgttcatc atatgtggct 1862281 gtttggaata aaatttctaa ctgttcatta cagcattaca catattaacc agcctattga 1862341 aagaacctaa cacaaagaag aagcttcgtc tgccagttgt aatgagatga actgttttaa 1862401 aattctgcac cgcatcaaga caggaaagga agggtttatg gtgttttata tcagtttatt 1862461 tctgattctt tggctggctg ctgggtttgc agtgggaatg aaacaagtgt atgtcgatca 1862521 gctgtttgat aaagctgtga tcgaaagact ggaaaaagaa gcgaatgatc atggacatgc 1862581 tgaccggatg atcaaacagc gcgtccttta tattgcagca gtgacagtaa gcgggtttat 1862641 ttctgtttat tatgaaatga aaacaatccc gcaaaggcga aacataagaa aaattgaaaa 1862701 aaacatcatg aaattaaatc aagcaaaaaa acgaagaatg aagagaaaat aaaaagtgca 1862761 caggccaaag ggcaggtgca tttttgtttt gtatggaaaa tgggggaggt ggtgccagct 1862821 tacttttcat aaattcaaaa atgagaagaa cagcgcccgg gctaatggta tataatattg 1862881 tgaatttaac aaaaatttaa caaggaggac gagagaattc gtgctaaagc ctcaaagaga 1862941 cctacattct gttgatttgg acttagaggc ggagtagatg aaaccggcca aagtatccct 1863001 gctccgccgt ttgctccatt ccttgaagca tgttgattgt aacatagcca aacgttttcc 1863061 atcaactatt aaaattgtaa aattattgat gatttttatg gtgtttactc cgatttcttc 1863121 aatttatgct gaagatgtat atcagaattt tgaggaatta aaaaacaatg aagatccttc 1863181 tgattatggc gttgttacga aagaaaccgg aagccctgtt cttgttttag ctattcacgg 1863241 aggaggtatt gaaggcggga caagtgaagt agcgagagag ctcagcaaag agtactcgat 1863301 gtatttattt gaaggcttaa aatcggcagg aaactcagtc ctgcacatta cgagcacaca 1863361 ctttgatgaa cctcgggccc ttaaaatgac gggaaatcat gaatatgtca tttcattaca 1863421 cgggtacgca gaagaagatc agcagatcga agtcggcggt acagatcgcg taagagcggc 1863481 agatttagtt gagaaattgc agcatgccgg ttttcctgct gtattgctca atatggacca 1863541 tccgcatgcg ggcgttagtc cgaataacat tgcaaataaa tcaaaaacag gtttaagtat 1863601 tcagatagaa atgagcacag ggtttcgaaa gtctttgttc ggcatctttt ctttaaaaag 1863661 cagagctgtt actcaaaatg agaggtttta tgagtttaca gaagtgatgt tccgttttct 1863721 caaaaatagc tactgaaaaa taggaggcga taagacagcc tcctattcct tatgcttctc 1863781 tttcgtttcg ggaaacagct cgtccgcggc ttccgtttga tactgcaacg tgttatctct 1863841 cgctgacagt tcatttcgga aattttcatc aagcacattt ttcagtaaat accgatgaaa 1863901 aaagtattca aaaacagtaa gacaggcagc ggaaaggaga gccgctccaa atggtgagaa 1863961 atcgtttctt gtttgggtta aaacaaatac ccaaagaata acgaatgaaa ggccaaagtc 1864021 agccaatgaa gctgtaatat tgtttgttct gggtaagacg agcatgtcac cagaaagata 1864081 ggaaacaaaa cctaagaaaa gtgcaataaa catcacactt aaaaaggatg cgtgatagac 1864141 tctgtccaaa atcacatata aaagggcgag agtgaaagca atctttgaag caagcgcaat 1864201 gatatgtttc atttgaccac ctaaattgtt attttttgaa gaaaattctt gggcgtaaac 1864261 aaatgataaa taatgcaatt caaaaccatt cataatggtc atgttactat tttaaacagt 1864321 ccgtttttgt ttacactggt atttttttca gctgtatgaa actttcttat gaaaaaagtc 1864381 gtatatgtgg atgatcagct ttcaaggggg gaatgatttg tggagataaa aggaatcaat 1864441 cacttgctat tttcagtttc gcatttggat acatcgattg atttttatca aaaagtgttt 1864501 ggtgcaaagc ttttggtaaa gggaagaaca actgcatatt ttgatatgaa cggcatctgg 1864561 ctagcgctta atgaagaacc agacatcccg agaaatgaca ttaagctttc ttatacccat 1864621 attgctttta caattgaaga tcatgaattt gaggagatgt cagctaaatt aaaaagactt 1864681 catgtcaata ttctgcctgg cagagaacga gatgaacgcg atcgaaaatc aatttatttt 1864741 accgaccctg acggccacaa atttgaattt cataccggaa cccttcaaga caggcttcga 1864801 tattacaaac aagaaaaaac gcatatgcac ttttatgatg aaacggcctt ttgatagcac 1864861 aaccatattt catataaggt taaatttaaa gaagggtgtt ggtggagact ttatgtttgg 1864921 ggaaggtttc tacccgactt gttcaacgat gccatatctt ttgaactgca caagtgattg 1864981 ggtgaaggtg aaattgaaat acacattaca ttacatttta tatgaagaaa gcgagctgtt 1865041 ttatcaaatg ttgaactaat taaactatgt actaaatttt cagtatattt caattgcttt 1865101 gccccttaat aaatataaaa ccgcatcctt ccacgaccta aaaaatgaaa cgtttttaag 1865161 aagatggcgt ctaatattct aaatgttcat attttgataa aagtttccta aaggaaagaa 1865221 aatttcttga cttcaacaat cttttggtgg ataattatgg tgtaaacatg atgttctttt 1865281 tcctcctatt cgggctcgca cccaaaagtc agggcgagcc tgcttttttt gaacaacaaa 1865341 ccccctctcc gtaaaggaag agggggttat tttatgcatc tgatagatca atagattaat 1865401 ggacggttct gaacacgcca atcactttcc ctagaatgct gacattctgc aaaatgatag 1865461 gttccatcgt tgggttctca ggctgcaagc gaatgtgggt atcctcttta tagaatcgtt 1865521 ttacagttgc ttcatcatct tctgtcatcg caactacaat ttccccattg ttcgctgtgt 1865581 tttgctgttt aacgatgaca tagtccttat cgagaatacc agcatctatc atactgtctc 1865641 ccataatctc cagcataaat acatgctcgt ctggaggaac catgcggtca gggagcggaa 1865701 aatattcttc aatattttct actgctgtaa taggagatcc cgccgtgact ttcccgatga 1865761 ccggtacatt aacgacctgg ctttgcggaa tgtctacttc ttcatcaaga atttctattg 1865821 ctcttggttt tgtcggatct cgtctgatca gcccttttgt ttccaaacgg gccaaatggc 1865881 cgtggacagt agaactggac gcaagcccga cagcctctcc gatctctctc acggaaggcg 1865941 gatatccttt tgatttaacc tctgctttaa taaaacggag gatatcaagt tgcctttttg 1866001 atagcttcgt catttttcgc acctcaaaac gtcgatttta agaagattat agcatgattt 1866061 tccttacagt acaaacatag gttcgaaaaa acaattgaca gaaacgtttg ttcgtatata 1866121 ctgaaattat aaaaatgcga acaaacattc ctgttggagg ttatgatcat gagtaaagaa 1866181 tctattattt ttgtcggtct gtttacagtg attttgagcg cggttatcct tatgctgtca 1866241 tatacaagca gcggccaaga gcttaatcag tatgttaaaa tagaagtcca gcaaggcgac 1866301 acactctggt caattgctga tcaggtagcc gatacaaaaa agataaacaa aaatgatttt 1866361 attgaatggg tagctgataa aaatcaactt caaacctctg atatccagcc gggtgatgag 1866421 ttagtgatcc cattgaaaaa gaagcatcag gatgcatatg aattagcaac tgtaagatag 1866481 agaggaaaga gagataaaat gaaagcactc atttatgccc gtgtaagcac aaataaagaa 1866541 cagcaggaaa cgtcattaaa gcggcaggag gaggagctta cggccattgc agcggagaac 1866601 ggcatggaag tggtcaaagt gatttcagaa aaagccagcg gatatgaaat ggatcgggat 1866661 ggtgtatttg agctgctcga tgagattaag aacgctgata ttgatgtcat tttggttcag 1866721 gatgagacaa ggctcggacg gggaaacgca aaaatcgcac tgcttcattg tatttataga 1866781 gaaggtgtga aagtctatac aacggctcat agaggtgaac tggagttatc ggaggctgac 1866841 tcaatggtct tggaaatcgt cagcattgtg gaagagtatc agcgaaagat tcacaacatg 1866901 aaaatcagac ggggaatgaa acgtgcagta aaaaacggtt ttaaaccgca aaaaaactta 1866961 aaaaaccaac atgggaacag tggaaaagaa aaaatagagg tgccaatctc agagatcgtc 1867021 cgcctgagag cgaataaact gacgtttgct gaaatcgcgg ctaccctaag agggtttggc 1867081 tatgatgtct ctaaagcaac cgttcaccgg cgttttcagg aatacataga gaatgaagag 1867141 actgcagagt gaatcagttg taaaactttt tttgatctag tactatatag acaaaatgca 1867201 ataaaggagt ttaacatgat ttcaaacgcg aaaattgcca gaattaatga acttgctgcc 1867261 aaagctaaag ctggcgttat tacagaagaa gaaaaagccg aacagcaaaa gctccgtcaa 1867321 gagtacttga aaggttttcg ttcttctatg aagaacacgt taaaaagtgt gaaaatcatt 1867381 gacccagaag gcaatgatgt tacaccagaa aagctaaaaa gagaacaaag aaataacaaa 1867441 cttcactaat ataagaggaa tacggcaata tcgtattcct cttttgcata tactataatc 1867501 aaaactctta tgtgacaaaa ttcaacaagt ttctctcaaa tttaagctga aacagttgag 1867561 aaaaagtcgt cagacattta tgatgtaagg gtacaacaca taaggaaggg gatttttatg 1867621 gatacaattg aaaagaaatc agttgctacc attcgcacac tgtcaataga cgctattgaa 1867681 aaagcaaatt ctggtcaccc agggatgccg atgggagccg ctccaatggc atacacgctg 1867741 tggacaaaat ttatgaacgt aagtccggca aaccctggct ggtttaaccg tgaccgtttt 1867801 gttttatctg ctggacacgg gtcagcacta ttatacagca tgcttcattt aagcgggttt 1867861 gatcttagta ttgaagatct taagggattc cgccagtggg gcagcaaaac accaggacat 1867921 ccggaattcg gacatactgc cggtgttgat gctacaacag gtccgcttgg ccaaggaatt 1867981 gccatggcag tcggtatggc aattgctgaa cgccatttag cggaaacata caaccgcgat 1868041 tcatttaacg tagtcgatca ttatacatac agtatttgcg gtgatggtga tttaatggaa 1868101 ggtatttctt ctgaagccgc ttcactcgca ggccatcttc agcttggccg tctgatcgta 1868161 ctatacgatt ctaatgacat ctctcttgat ggagacctcg accgttcatt ctctgaaaac 1868221 gtgaaacagc gttttgaagc aatgaattgg gaagttcttt atgttgagga tggaaacaat 1868281 attgaagaat taacagcggc tatcgaaaaa gcacgccaaa atgaaaagaa acctacatta 1868341 attgaagtga aaacgacaat cggattcggt tcacctaacc gtgccggtac atccggtgtt 1868401 cacggtgcgc cgcttggtaa agaagaaagc aaattaacaa aagaagctta cgcgtggaca 1868461 tatgaagaag acttctacgt tccgtcagaa gtttatgagc atttcgctgt agctgttaaa 1868521 gaatcaggtg agaaaaaaga acaagaatgg aatgctcaat tcgctaaata taaagaagtt 1868581 tatcctgaac ttgctgaaca gcttgaactg gcaatcaaag gagagcttcc gaaggactgg 1868641 gatcaagagg ttcctgtgta tgaaaaagga agcagtttgg catcccgtgc atcttccggt 1868701 gaagttctca acggacttgc gaaaaaaatt cctttctttg tcggaggttc tgctgaccta 1868761 gcgggatcga acaaaacgac tattaaaaat gccggtgatt ttacagcggt tgattactca 1868821 ggcaaaaact tctggtttgg tgtacgtgaa tttgcgatgg gtgcggcctt aaacggtatg 1868881 gcgcttcatg gcggtcttcg tgtattcggc ggaactttct ttgtcttctc tgattacctg 1868941 cgtcctgcga ttcgccttgc agcgttaatg ggccttcctg tgacatatgt cttcacacat 1869001 gacagtattg cggttggtga agacggtccg acgcacgagc ctgttgaaca gcttgcttca 1869061 ctccgtgcga tgcctaacct ttctttgatc cgtccagcag acggcaatga gacagcagca 1869121 gcatggaagc ttgcagtgca aagcactgac cacccaacag cgctagtgct tacacgtcaa 1869181 aaccttccta ccatcgatca aacatctgaa gaagcattgg caggagtaga aaaaggtgca 1869241 tatgtcgttt ctaaatctaa aaacgaaaca cctgacgctc ttctcatcgc ttccggatca 1869301 gaggtaggtc ttgcaattga agcgcaggct gaattggcaa aagaaaatat cgatgtttct 1869361 gttgtcagca tgccttcaat ggaccgtttt gagaaacaat ctgatgaata caaaaacgaa 1869421 gtccttcctg cagatgtgaa aaaacgtctt gcaattgaaa tgggctcatc atttggatgg 1869481 ggcaaataca cggggcttga aggtgacgtt ctcggcatag accgattcgg tgcatctgct 1869541 cctggtgaaa ccatcattaa cgaatacggc ttctcagttc cgaacgtagt gaatcgagtt 1869601 aaggcattaa tcaataagta agcttttgaa agaggatgag tcaaatcatc ctctttttct 1869661 tgtttatccg acaaaaatag tattggctgt ttaacagtaa tagacaattc tttcttttct 1869721 tcttttgtat aatagagagc aaatgaaatg ctgctggaaa aggggatgaa aagatggaac 1869781 gtcactacta tacgtacctg atcaaagagg aatttgccaa tcactatttc ggccgggaat 1869841 cggttatgtt tgagctgttt caagactatc attggacaag ccttgaaaag cagcagtatg 1869901 aaatgacaga gaaacagatt caatatatta cacaaccaat cccgatttta catatgcatc 1869961 agcggttaaa aatgaattta aacaagacgg attacaggca gctggattat atttatagaa 1870021 tagctttgcc gaaagcaaaa ggccacgcga cgtttatgat gaaggagcac atgatagaaa 1870081 ttgtggcttc gggagattac gaggcagaaa cgatattctt tgaagtgtta agaaaagtaa 1870141 gcccttgctt tttagcaatg gatttcaatt cgaagcgtta cggatggcta aatccggtga 1870201 aagaaagaaa ttttgtctaa aaccgaagaa aaagagatgt aaatgttgta taatagcttt 1870261 tggtttagta cactttaaac tagacaacat gaaggaggaa ataaaatgac tttatgggtt 1870321 ggcatcctag tgggcgttgt tgcattgctc ataggtgttg cactcgggtt ttttattgct 1870381 cgtaaatata tgatgagcta cctgaaaaag aatccgccta ttaatgaaca aatgttacgc 1870441 atgatgatga tgcaaatggg aatgaaacct tctcaaaaga aaatcaatca aatgatgaaa 1870501 gccatgaata atcaaacgaa ataatacgta aagattatga tatagagaaa catggttata 1870561 aaataaaaaa cccttatacg ggttttttat tttgcaatca ttcatcaccc gctactgctc 1870621 gaaggcgctg cttttgatat tgtatgagaa gatggtcaag ctcctgactg agctctatcg 1870681 taatatgaga tgtcattccg ttcgccatga caatttgcag cagctctgct cttttttttt 1870741 caatttcttt taatagatgc tctctaatca cagggatgta tcctttcata cattagatct 1870801 tcaaagtgaa tgtttatatt atatccatat ttatactaat tttcaaatga gaaggagtat 1870861 aatgtctcaa tgtcaaatta aattatataa gttttttctg aaaatagaaa tccttcaagt 1870921 gaaagtgtta aaaaaatgaa atgattttgt cataacttga aggaatgtca aatcatgaag 1870981 ggatgatgac atgggagacg tgaattattt tttgacattc ggagcggggt ttttatcctt 1871041 tatttcgcct tgctgcctgc cgctttaccc agcttttttg tcatatatta caggggtcag 1871101 catggacgat gtaaaaactg aaaagctgct gctgcagaaa agaagcttgt ttcatacttt 1871161 gtgttttttg cttggctttt cagtcatttt tattgcttta ggctatggaa catcttttat 1871221 tggcagcctg tttagggatt atcacgatgc gattcggcaa attggcgcgt tgcttattat 1871281 tttgttcggt ttcattacac tcggtgtgtt ccggcctgag gctatgatga aagagcggag 1871341 aatccatttt aagcataaac caagcgggtt tttagggtcg gtcttaatcg gaatggcatt 1871401 tgcagctgga tggacaccat gtaccggtcc gatattagct gctgttatca cacttgcagg 1871461 caccaatccg ggctcagcgg tgccatacat gatgttatat gtactcggtt ttgcggtacc 1871521 gtttctttta ttgtcttttt ttatcacaaa gctgaagtgg ataaggaaga accagctttt 1871581 cattatgaaa gctggtggcg ttttgatgat tgtgattggt gtgctgttat tctttaattg 1871641 gatgagcctg atcattattt tgctgtcaga tctttttgga ggctttactg gtttttgacg 1871701 gtaaattact ttcgtactac tactaatcct tttgtttttg gtacaataag actattatct 1871761 gtggaaatcg attgttggag gggaatatga caagagtttt agttgtagac gacgccaagt 1871821 tcatgagagt gaaaatcaga gagatcttgg aagaggcaaa ttacataatc gcaggcgaag 1871881 cggcggacgg tgaacaagca gctgacctgt ataaaaaact gcgcccggac cttgtgacaa 1871941 tggatattac aatgccggtg aaaaacggca taaaagcgct tcgtgatatc ttaacctttg 1872001 atcctaaagc gaaggtcatc atgtgcaccg ccatgcgcca gcaaagaatt gtaacggaag 1872061 caattgagct gggggcaaag gattttattg ttaagccgtt tgaggaaaca aaagtgctgg 1872121 aagctgtaag ccgcgttatg ggacattaaa gtcatttctt ttcaaaatgg ttttttttat 1872181 tgttttggag tatagtatat agtatcaaca ctccgagaaa caaaggaatg ataagtatga 1872241 tgattatagt ttcatcaatt attgctgtgt taatggctgt agctgtgatg gtggtcagaa 1872301 taaagtcctc tgacaagcct gtttcaccaa aaaaaatcat tcttccgccg atttttatga 1872361 gtacgggagc gttaatgttt ttatttccgg tattttgggt aactggagca gagtttttgg 1872421 aagcattcac tttaggtgtg attttctcta tttttctaat caaaacttct aagttcgaaa 1872481 ttaaaaataa tgaaatttac atgaaacgct ctaaagcatt tgtttttata ttagtcggtc 1872541 ttttggtgat cagaatcgtg atgaaatcga tcttgagcac atcaattgat tatggtgcac 1872601 tgagcggaat gttttggatt ctggctttcg gtatgattgt gccttggaga atcgccatgt 1872661 atttatcata tcgaaaactt cataacgagc tgcagtcatc taatattcaa atgaattaaa 1872721 aaacctttcc tcttgtcagg aaaggttttt tatttgagaa gggtctgata aggttccaaa 1872781 tcgatttttt tgtcccgcag atgccttttt aagaaggtat ggtctctttt aggagttgcg 1872841 agaatatagc ctttgatcat aagttgctga tcaatctttg ctaccttttc ttttaatgca 1872901 agctcaccga ttttgcctgc gattttagct tttgctgcat ctctgaacag ctctggcacg 1872961 ggcgcagtca attcatctag aaactgtttg ttttcatcgt tccataaatg tctgctgttt 1873021 tcaatatagt aatcctgcca atcaagctct gatctgccgt cctcttttgg taaacgcttt 1873081 aaaaactttc gaaacatgaa aaaaccgccg attgataata agactaccat catgattacc 1873141 caaaacagaa taaaccataa aaaccatcct tccagcatca atcattcccc cttattctaa 1873201 ccatattgta tacgaagaga gattagaaga acacagtaaa aaaagaatag aaaaaagtga 1873261 tagacgtcta gtcaaaagag atagtagatc atattctatt gtatagtgaa tctgctattt 1873321 ggccatggga gagtcactag agggtatttg acgataaatg gacggaaaaa aagtcacttt 1873381 cataataggg gatgaaagtg actttttatg tttagctgag aggaaattga agagaaaaag 1873441 aagagccatc ttctgtttct ttattgacgg cgactgtgag tatttgattt tcgcattcga 1873501 cttgaatgtt tttgtcatta aaataaaaag gaagcatcat ttgtttttca aaagtctgtc 1873561 ctgacgattt gacagttaag atgaactcgc atccagaaag ggtaactgtt acttgtgtag 1873621 gctgtaaaaa agtcagatcc gcttctataa tatactgctg acttgtttca tataaatcaa 1873681 taggcaatgt ttcgtcgtac caggcgaagg ggtcttcaaa aaattgccga agccattcat 1873741 ccatactatc gaaatcattc gcatcgttgc gttttgaatg gttcatggaa gcattcctcc 1873801 acatatcaac cttgctttac atcatatgcg gtggattata aatgggtgaa cgcataaaaa 1873861 aacagacact aaggtctgct tttcttacat atcatggctt gagttgtgct tttgtcttgt 1873921 atggtttcgg ttttttactt ttttgcttcc gcttagaggc tcgggttggc cgggattgtg 1873981 tcctttaggg gcgtttttat gcatatcttt acttgtattc ttattggtca taaaatgaga 1874041 acctccttaa aagagttcgg tgttattgat tggtttttct ttttttgtta ttttggcgtt 1874101 ctgcttcagt cagtacaagc tggtcgtttt caatatagcc ggcgcctttg ccttggcttt 1874161 ttgcgtcatt cattccgtta atgacgtgat tcgcttttct tttgaccatc attatcacct 1874221 caatcataat atggcttctt ttattgtgtt atatgagaga gcgtaaacag taaaaattac 1874281 cggtacattt ttctcataag tcgaacttat tgtatttaat aaaaacattg atatttactt 1874341 atgtatgatt ttgttttaat atgaaattgt gagaaaattg tgatggaatg taatgttcat 1874401 ctgagaatga tctgatctga agggggattt tggagaatgg caaacgagca aaaaactgca 1874461 gcaaaagacg ttttccaagc gagaaaaacg tttactacaa atgggaaaac atatcattac 1874521 tactctttaa aagcgttaga agattcaggt ataggaaagg tttcgaagct tccttattcc 1874581 atcaaagttc ttttagaatc agtattgcgt caagttgacg gcttcgttat caaaaaagaa 1874641 cacgtggaaa atttggcaaa atggggaact gccgaattaa aggatatcga cgttccgttc 1874701 aaaccgtctc gtgttatttt acaagacttc acaggggttc cggcagtagt agatctggct 1874761 tcactgcgta aagcaatggc agctgtcggc ggagatcctg ataaaatcaa ccctgaaatt 1874821 cctgttgatc tcgttatcga tcactctgta caggtagata aagcgggtac agaagatgca 1874881 ttagcagtaa atatggactt ggaattcgaa agaaatgcag agcgctacaa atttttaagc 1874941 tgggcaaaga aagcgtttaa caattatcag gcagtaccgc ctgcaacagg tattgtgcac 1875001 caggtcaacc ttgagttctt ggcaagtgtt gtccatgcca ttgaagaaga cggcgagctt 1875061 gtaacgtatc ctgatacgct tgtcggaaca gactcacaca caacaatgat taacggtatc 1875121 ggtgttctcg gctggggtgt cggtggaatt gaagctgaag cgggaatgct tggacagcct 1875181 tcttacttcc cagttccaga ggtaatcggc gcgaaacttg tcggcaagct tccaaacgga 1875241 acaacagcta ctgacttggc gttaaaagta acacaagtgc tgcgtgaaaa aggcgttgtc 1875301 ggtaaatttg ttgaattctt cggaccggga attgctgaac tgccgcttgc agatcgcgca 1875361 acaattgcga atatggctcc ggaatacggt gctacatgcg gattcttccc agtagatgaa 1875421 gaagcgctta actacctgcg cctgactggc cgtgatcctg aacatattga tgttgttgaa 1875481 gcatactgca gaagcaatgg cttgttctac actccagatg cggaagaccc tcaatttact 1875541 gatgtggttg aaattgacct gtctcaaatt gaagcaaact tatcgggtcc aaagcgtcct 1875601 caggatttga tcccgctatc tgctatgcag gaaacgttta aaaagcaatt agtcagccct 1875661 gcaggtaacc aaggattcgg tttaaatgct gaggaagaaa ataaagaaat taagtttaaa 1875721 ctccttaacg gcgaagaaac agttatgaaa acgggtgcga tcgccattgc tgcgattaca 1875781 agctgtacaa atacatcaaa cccatacgtg ctgatcggcg ccggactggt agcgaaaaaa 1875841 gcggttgagt tagggcttaa ggtgcctaat tacgtgaaaa cgtcacttgc accgggttct 1875901 aaagttgtta caggatatct tgtgaattca ggccttcttc catacatgaa agagcttggc 1875961 tttaacctcg ttgggtacgg ctgtacaaca tgtatcggga actcaggtcc gctttcaccg 1876021 gaaatcgaag aagcggttgc gaaaaatgat cttctgatta cgtctgtcct ttccggaaac 1876081 cgtaactttg aaggacgtat tcacccgctt gttaaaggca actatcttgc ttcaccgccg 1876141 cttgttgtgg catatgcgct ggctggaacg gtaaacatta acttaaaaac cgatccaatc 1876201 ggtgtgggca aggatggtca aaacgtatac tttaatgata tttggccgtc aatggacgaa 1876261 atcaatgcac ttgttaagca aactgttacg ccagagctat tccgcaaaga gtatgaaaca 1876321 gtatttgatg acaacaagcg ctggaacgaa attgaaacaa cagatgaagc tttatataaa 1876381 tgggataacg attcaactta catccaaaac ccaccattct ttgaagagat gtctgttgag 1876441 ccaggcaagg ttgagccatt aaaaggactg cgtgttgtcg gtaaattcgg cgattcagtc 1876501 acaactgacc atatttctcc tgcgggggca atcggaaaag atacgcctgc cggaaagtat 1876561 ttgcaagaaa aaggtgtttc acctcgtgac tttaactcct acggctcccg ccgtggaaac 1876621 catgaagtca tgatgagagg aacatttgcc aacattcgca tcaaaaacca aatcgcaccg 1876681 ggtacagaag gcggatttac gacgtactgg ccgactggtg aagtaacatc catctatgat 1876741 gcatgcatga aatacaaaga agataaaacc ggtcttgtcg tattagcagg aaaagactat 1876801 ggtatgggat cttcacgtga ctgggctgca aaaggaacaa accttctcgg catcagaacg 1876861 gtcattgcag agagcttcga aagaattcac agaagcaatc ttgtattcat gggtgtgctg 1876921 ccgcttcagt ttaaacaagg tgaaaatgcg gatacactcg gcttaacggg taaagaagtc 1876981 atcgaggtag atgttgatga aacagttcgt cctcgtgacc ttgtgactgt aagagcaatc 1877041 aatgaagacg gcaatgtaac aacttttgaa gcagtcgtcc gctttgatag tgaagttgaa 1877101 attgattact accgccatgg cggcatcctt caaatggtgc ttcgtgaaaa aatgaagcag 1877161 tcctgatgaa tcaataggaa gagaaggcat ttcgctttct cttcttttta tgacacaatg 1877221 tgctgcggag gtggcatatg ctgaaaaaat ggctcgcagg gatcctgctt atcatgctag 1877281 tcggttatac gggatggaat ttatatcaaa catacagcaa aaaagaagtc ggaattcaag 1877341 aggggcaaca agcacctgat ttttctttga aaacgctatc aggagagaaa agctctttac 1877401 aggatgcaaa aggcaaaaaa gtgctgctca atttttgggc aacttggtgt aagccgtgcc 1877461 gtcaggaaat gcctgcgatg gaaaagctgc aaaaagagta cgccgacaaa cttgcggttg 1877521 ttgcggtaaa tttcacttca gctgagaaaa gtgagaaaca ggtccgagcg tttgctgata 1877581 cttatgactt aacgttcccc attctgattg ataaaaaagg gatcaatgct gactataacg 1877641 tgatgtcata tccaacgaca tatatcttag atgaaaaagg tgttatccaa gacatacatg 1877701 ttggcaccat gacaaaaaaa gaaatggaac aaaaactgga tcttgattag attcagtttt 1877761 ttttatactc aaatatgctt acaagttttc agaattggaa aaaataaaag aatatgcgga 1877821 ggtgagaagc gtgaagaaga tgagaaaacg ttcttttcat gagctcgtca tggaaaacaa 1877881 aaaagagctg atgaccaata cagagtattt aaatcagctt gaggaaaagc ttgaacagcg 1877941 atttaagcaa aaataacctt taatttgtat tcatgtttac ccctcctttt gagaaaccta 1878001 tctgttgagg agggataaac atgggaaaca acaagaaaaa cggtcagcct caatatgctc 1878061 caagccactt gggtacaaag cctgtaaaat ataaagccaa taaaggggaa aaaatgcatg 1878121 atacttcagg acagcggccg attatcatgc agacaaaagg cgagtagcga aaattcgagt 1878181 ttatttctag gaggtacatc cgaatgacaa agaaccaaaa tcaatatcag cagcctaatc 1878241 ctgatgatcg ttctgacaat gtggaaaaat tgcaggatat ggttcaaaat acaattgaaa 1878301 atatagaaga agcagaagca tcaatggagt ttgcttcagg agaagataaa cagcgtatca 1878361 aagaaaaaaa tgcaaggcgc gaacagagca ttgaagcgtt tcgtaatgaa atacaggacg 1878421 aatctgcagc gagacaaaac ggataccgtt cttaaaaaac cagggaaacc tggttttttt 1878481 ctttctgatt tgattatggt aaaatggggc taaattgacg ttaagggagc agagtaatct 1878541 tgcatgtatc aaaaaaagaa atagaagtgc gttatgcaga aacagatcaa atggggattg 1878601 tctatcacgc aaattatctt gtgtggatgg aggtcggcag aacggccttg attaaggact 1878661 taggcttttt atatagtgat atggaaaaaa aaggcgttct gtccccagtc gttgatatca 1878721 atatttccta taaaaagccg cttcattacg gagaaaccgc ggttgtacat acatggatag 1878781 aggactataa cggatttaaa accgtctatg gttaccacat ttataatccg gccggtgagc 1878841 tttccatcaa agccacctca tctcatattt gtgtggataa agaaagcttt aagccaattc 1878901 aattccgcaa agcttttcct gattggcaca cagcatatga aaaggccaaa aaatagggaa 1878961 gtgaacggga tatggcgttt ggtgtgaaac gggaggaact taaccggtgg aaacaagcag 1879021 tgaaaagagg agaaatcgca tttttaacac attactggct ggatgaccga tttccagaag 1879081 caaagaccgt gacaaaagcc ggctgtgcag acattgataa gctggttcag tggggagcgg 1879141 cgtacgggtt aaaaaaagaa tggatccata agaaaagtga atttccccac tttgatctgc 1879201 tgggggaaac acaaaaatat attttggaac aagaaaacct aaccgatcat cttatacgat 1879261 ttcatttgta aaaaaagaac gcacatgaag tgcgttcttt tttattggta ttcaaaaacc 1879321 ggttcatcag cgtcttctga atagctgacg agaaggtcgt ggttatcaaa gtaccataaa 1879381 tcactttctt caataaagaa ggtaatgcca tcagcttctg cagtgactcc agcctcttgt 1879441 ggggcatctt tcgctacacc gagagaaaaa cccttttgaa cgttgctgca gcctccatag 1879501 cggacgaaaa agcgaacctg gtctccgctt tccaaatcga gttcttcttt ataccagttc 1879561 aatgcgtctt cgttaattgt catattcata acagaacacc cctttgttct tcatttgaat 1879621 tttctctatt ataaacgtat taggctattc tgtgtcaaaa gagaagtttt ttaagcttat 1879681 aaccatttta ctttaggttc tgttttattg ataattcgtt taatgttcgc tcggtgtctg 1879741 tatatcacaa aaatagtgag cagggtaacg acaatcaata aatacgtatc atggacaaag 1879801 aaactatata taacagtata gatccctgtt aacatcgatg agagagaaac aaatttagtc 1879861 aagtataaaa agatgaagaa taccgcaacc atcgtgataa ataacagggg tgcgtaaaat 1879921 agcaaaacgc ctcctgatgt cgccacggct ttaccgcctt taaatttggc gaagatggga 1879981 aacacgtggc ctaaaaccgc aaagactcct gcaagaagcg ggtgaatatc aacatgcatg 1880041 agaaaaggca atgcagttgc cagtgtccct ttcaaaatat ctccggctat gacgaccgaa 1880101 ccagctttta cacccaatgt acggaatgca ttggtagcgc ctaagttgcc gcttccgtgc 1880161 tcccgaatat caattccttt ggcaagcttg cccacaatta agccagatgg aatgctgcct 1880221 atcaagtagg ccaaaataat caataaagca attaacatct acatttctcc tttttcaaat 1880281 tcccttcttt ttattttaac atgagatgtc atgatctgat gataagtttt tttgtaaagt 1880341 ttgcttacaa atcaaatcaa acatgcatca tattttgatt tctcctgttt tgatcgtgta 1880401 aaataagtga aaaaggagtg acacacgatg caaaaccctt ctaaagcgga aattaaagag 1880461 attcttcaaa gaagcaaacg tatagcggta gtagggcttt cagaccgtcc ggatagaacg 1880521 tcacatatgg tttcaaaagc aatgcaggac gcgggttatg aaattatccc tgtgaaccct 1880581 acaattgatg aggcgctagg tgtcaaagcc gtttcatctt taaaagagat agacggtccg 1880641 attgacatcg taaatgtatt ccggcgctca gaacagcttc ctggagtggc ggaagagttt 1880701 ttagagacag atgcgccagt attttgggca cagcaagggc tagttaatga ggaagcatac 1880761 cagatgctaa aagaaaaagg cagaacggtt atcatggatc tgtgcataaa agtggcacac 1880821 gctgtaacaa aataggtgca gaactgcaaa aatccttgta aattcaagga tttttgcttt 1880881 ttaattttaa gatattgttt gcgtattacg gtgaaacaga tacaataaag cttgaacagc 1880941 tttttttgaa taccttgtcc agctgggttt cggccgttcg atttgcgaag gtctgctgct 1881001 ttatatataa taaacaaaca tacgttctca tagtgtaaaa acagcactag ccgatgtttt 1881061 gagaagaact gattcgttag ctctatgttg cgattgcaaa catattggtt ataatgagga 1881121 gtccaaggca gtactggctc gaggcgaggt ttataaaaaa tatcttatat acaaatgatg 1881181 tgtaacactg aaaagagaaa gacaatgtta gtttttgaaa ggggtttgta cgtttggcta 1881241 gaaaacagca atttgattac aacgaagatg ccatacaggt gctcgaaggc cttgaggctg 1881301 tcaggaaaag gccgggtatg tatattggct ctactgacgc gcggggtttg caccacttgg 1881361 tttatgaaat tgtagataac tctgtcgacg aggtgcttgc cggccatgga gatcacataa 1881421 tcgtcaaaat acataaagac aatagtattt ctgtacagga tagaggccgc ggcatgccga 1881481 ccggaatgca taagctcggc aaaccaaccc ctgaagtgat tttaacggtg cttcatgccg 1881541 gagggaaatt cggccaaggc ggctataaga caagcggcgg gctccacgga gttggtgcat 1881601 cagtcgtgaa tgctttatct gaatggctga cggttaccat tgagcgggac ggttttgtct 1881661 atcagcagcg atttgaaaat ggaggaaaac cggttacatc tctcgaaaag atcggcaaaa 1881721 caaaaaagac gggaactctt acacacttta agccagatcc aacgatgttc agcacaacca 1881781 cttataattt tgaaacgctc tctgagcgct taagagagtc tgcgtttttg ttaaaaggac 1881841 tgaaaattga gctgattgat gaacgcaatg accagcgtga ggtcttttat tatgaaaacg 1881901 gcatagaagc gtttgttgct tacttaaatg aagaaaaaga cgtcttgtct gaagtggtct 1881961 cgtttgaggg tgagcatcat tctatagaag tggactttgc gttccagttt aacgatggtt 1882021 attctgaaaa tattttgtcg tttgtcaaca atgtcagaac aaaagacggc gggacgcatg 1882081 agtcaggtgc aaaaactgcg atgacgcgtg cttttaatga atatgcgcga aaagtggctt 1882141 tgctgaaaga aaaggataag aaccttgaag gcaccgatat aagggaaggg ctttcagcca 1882201 ttatttctgt ccgcattcct gaggagcttc ttcaatttga gggacaaaca aaaggaaagc 1882261 tcggtaccag tgaagcaaga tcagcggtgg atgcgattgt ttcagagcag cttgcttact 1882321 ttttagagga aaatcgggac accgcaacgc ttcttgtcaa aaaagcaatc aaggcgagcc 1882381 aggcgcgcga agcggcacgc aaagcccgtg aagaagcaag aagcggcaaa aaacgaaaaa 1882441 aatcagaagc gactttaagc ggaaagctga cgcctgcggg ttcaagaaac ccggcaaaaa 1882501 atgaattgta tctcgttgag ggagattcag caggcgggtc agccaagcag ggacgagacc 1882561 gcagattcca ggcggttctg cctttacgcg gtaaagtcat taatacagaa aaagctaagc 1882621 ttgctgatat ctttaaaaat gaagagatca atacgatcat tcatgcgatc ggcgggggag 1882681 tcggggcaga tttctcaatc gatgacatca actacgacaa aatcatcatt atgaccgatg 1882741 ccgatactga cggcgcccat attcaagtgc tgcttcttac ctttttctat cgctatatga 1882801 aaccgctcat tgagcatggc aaggtgttca ttgcgctgcc acctttatat aaggtcagta 1882861 aaggaagcgg gaaaaaggaa atcattgaat atgcatggtc tgatgaagag atgggggatg 1882921 tcctgaaaaa agtcggcaaa ggctatacca ttcaacgata taagggtctt ggagagatga 1882981 acgcagacca gctgtgggaa acgacgatga atccggagtc ccgcacactt gttagggtca 1883041 aaattgacga tgcggcacgt gtagagagac gtgtgacgac gttaatggga gacaaagtag 1883101 agccgcgcag aaagtggatt gagaaaaacg tcgctttcgg cttagatgaa gaaagcaata 1883161 ttttagaaaa tgaaaactta tcggtcgctg aggaggttta atgattgtca cagccagaat 1883221 tatttcatga tttaccatta gaagaggtga tcggcgaccg ttttggacgc tacagtaaat 1883281 atattattca agacagggcg ctgcccgatg cgagagacgg attaaagccg gtacagcgca 1883341 gaattctgta tgcaatgcat acagatggaa acacgtttga taaaaacttc agaaaagcgg 1883401 ccaaaacggt cggtaacgtc atcggtaact atcatccgca cggtgacagc tcggtttatg 1883461 aagcaatggt gcggatgagc caggattgga aagttcgtaa tgtgttaatc gaaatgcatg 1883521 gaaacaatgg aagcatcgac ggagatcccc cggcagccat gcgttataca gaggcacgat 1883581 tatctccgat agcatctgag cttcttcggg atattgacaa aaacacggtt gaatttgtgc 1883641 cgaacttcga tgatacaagc aaggagcctg tcgtactccc ggcgatgttt cctaacctat 1883701 tggtcaacgg atctaccggg atttcagcag gatacgcgac cgacattccc cctcatcatc 1883761 tgggagaagt cattgatgct gtcattaagc gtattcaaat gccttcttgc tctgttgacg 1883821 aactcatgga agttattaaa gggcctgatt ttccgacagg cggtattatt cagggcgttg 1883881 acgggataag aaaagcttac gaaaccggaa aaggaaaaat cattatccgc ggaaaggctg 1883941 aaattgaaac aatcagaggc ggacgagaac aaattgtcat tactgaaatt ccatttgaag 1884001 taaataaagc aaaccttgta aaaaaaatgg acgagttccg tattgataaa aaggttgaag 1884061 gcatctcaga ggttcgtgat gaaacggatc gaacagggct gagagtggtc attgaactga 1884121 aaaaagaagc tgatgccaaa ggcattttga atttcttata taaaaatact gatttgcaga 1884181 tcacatataa cttcaatatg gtggctatcc ataaccgccg tccgatgctg atgagcctgc 1884241 cgtctatttt ggatgcatat atcggacacc aaaaggaagt tgtcacaaac cggtccgttt 1884301 acgagcttca aaaagcaaaa gacagacatc atatcgtaga agggctcatg aaagctttgt 1884361 ctattttgga tgaagtgatt gcaacaatcc gttcttctag cgataaacgt gacgctaaaa 1884421 acaatttgat cgcgaaatat gaatttacag agcctcaggc tgaagccatc gtgtcattgc 1884481 agctatatcg tttaaccaat accgatatca cagcgcttaa ggaagaggca gaagagctcg 1884541 gtaaaaaaat tgaagagctc gaatctattc tgagcaatga taaaaaactg ctaaaagtga 1884601 ttacaaacag cttaaaagca ctgaaaaaga aatatgcaga tacgagacgc tccgtgattg 1884661 aagaaaaaat tgaagaaatt aaaatcaatc tcgaagtcat ggttgcatct gaggatgtat 1884721 atgtaaccgt tacgaaggat ggttacctaa aacggacgag ccagcgctca tttgccgctt 1884781 ccaacggtca ggacttcgga atgaaagata cggacaggat gctgcatcag tttgaaatga 1884841 atacgacaga cgtgctgctg ctctttacga acaaaggaag ctacatctat tgtcctgttc 1884901 accagctgcc tgatatcaga tggaaggaca tgggccagca tttttcaaat ctaatcacta 1884961 ttgaccgtga tgaaacgatt gtaaaggcta taccgataaa agaatttgat ccgtcggcat 1885021 atcttctatt ctttacgaaa aacggtatgg tgaaaaagac agagctcact cattataaag 1885081 cacagcgtta ttctaaggca cttgtagcct taaatctgaa gggtgaagat gaactgattg 1885141 atgtacatgt aacaaatggg gaaagccaga tctttatggc cactcactta gggtatggtc 1885201 tatggtttgg agaagacgaa gtgaatgtag ttggcgcgcg tgcggcaggt gtcaaaggga 1885261 ttaacttaaa agaggatgac tttgttgtct ccggtgagat tcttcagcaa tctgattcaa 1885321 ttgtcttgtt cacacagcgg ggagcggtta aacgcatgag tctttctgag ttcgagaaga 1885381 catcccgtgc aaaacgcggt gtcgtaatgc taagggaact gaaaaagaat cctcaccgtg 1885441 ttgtagcact gttcgcttgc ggtcttgaac agcgactaat ggcagaaaca gaaaaaggcg 1885501 acagaaaaga actgcagaca aaagagttgc ggacaaacga cagatacagc aatggctctt 1885561 tcttttttga tgaagaggaa tcaggcaagg ttacagctgt ttggcgcctt catacagaac 1885621 aataataaaa aacccgctca tactatatga gcgggtttcg tttgtttttt atcagctttc 1885681 atggttggtg aatagatctg ttacagcatg aatgacttca atcccctgcc atacaaataa 1885741 attcagcgct gtgaaagaaa ataagcctaa aatcaccatt cttaagataa acaacatgtt 1885801 taacagcctc ctcatatttt cgttacataa tcgggtgatg ttgaacatga agtttgccga 1885861 aataagacga ttgataaaat ttggccagta taaagctttt tttccgctga cgtctgcggg 1885921 agtatcccgt acttttgctt tcagcggtca gcagcagaac agccattgcc cataaagcgg 1885981 tcagcgtaaa tgcccctgtg atggatttct tctcatcatc agcattttgg ccggctttca 1886041 tctcatgcat ttcctgctgg tcggctacgg ctttataatg atggccgata tcaaaggcgt 1886101 ggggaattga gaacaaatga aaactggcaa tcgccaagaa taagatggat gctttcaata 1886161 tcgttacttt tttcaaatga tctccccctc ctttaatatt actgaatatt tttataataa 1886221 taccccaatc catcctaaaa gtaaacctga tttattaaat ttaaaaataa atttaacttt 1886281 gttaagtata tatctttttg cttatttttg aaagagaaaa cttcttttat tagcgtatgt 1886341 atacccggtt tatggtgtga ataaaaacat attttaaatg atatgttgtt taggatttat 1886401 tactttattt atgtgtaaat caaagagaaa ggcaagagaa tgggaagaaa tgattacatt 1886461 gttaataggg tactcttttt ttaaagccag tttgcaagga atgtttttat tcgtaggaaa 1886521 ataatagaga aggggtcgac agagtaacat ctggctatga caatattctt ctcgaaaaaa 1886581 cttcctaatt cgtcatattg tgatataata aaactcgtta tgttaaaaaa tctaacatca 1886641 aaatcgaatt cgtattgaat tgatgaaaac gggaggtaaa tatggagtct tttttcaata 1886701 gtttgattaa tattccaagt gatttcatct ggaaatacct attttatatt ttaatagggc 1886761 ttggattatt ttttaccata cgttttggtt ttatccaatt ccgttatttt attgaaatgt 1886821 tcagaatagt aggggagaag ccggaaggaa ataaaggtgt ttcatctatg caggcattct 1886881 ttatttcggc cgcatcccga gtcggcacag ggaatttgac tggtgtagcc ttagcaattg 1886941 cgacaggcgg accaggcgct gtattttgga tgtgggtagt ggctgcagta ggcatggctt 1887001 caagctttgt cgaaagtaca ttagcacagc tttataaggt aagagacggg gaggatttcc 1887061 gcggagggcc ggcctactat attcaaaagg gtcttggtgc cagatggctt ggcatcgttt 1887121 ttgcaatctt aattaccgtc tcattcggct tgatttttaa cgctgttcaa acaaatacaa 1887181 ttgctggagc attggatggc gcattccatg taaataaaat agttgtagcc atagttctgg 1887241 cggttttaac tgcgtttatc attttcggcg gtttaaaacg tgttgtcgct gtttcacagc 1887301 taattgtgcc ggttatggca ggcatttata ttcttatcgc tttatttgtt gtcatcacga 1887361 atattacggc tttccctggc gttatcgcta caattgttaa aaatgcttta ggttttgaac 1887421 aagtcgtcgg cggcggaata ggcggcatca tcgttatcgg tgcgcaacgc ggactttttt 1887481 caaacgaagc aggaatgggg agcgcaccaa acgcggctgc gacggctcat gtatcccatc 1887541 cggcaaagca aggctttatt caaacattag gcgtattttt cgatacattt atcatatgta 1887601 cgtccacagc atttattatt ttgctgtaca gtgtaacgcc aaaaggcgac ggcatccaag 1887661 tcacacaggc tgctcttaac catcacattg gaggctgggc gccgactttc atcgcagtcg 1887721 caatgttctt gtttgcattc agttcagttg tcggcaacta ttattatggc gagacaaaca 1887781 ttgaatttat taaaacaagc aaaacatggc tgaacattta ccgtatcgct gttattgcta 1887841 tggttgtgta tggatcttta tcaggcttcc aaatcgtttg ggatatggcg gacctcttta 1887901 tgggtatcat ggcgctgatc aacttaattg tgattgcgct gctgtcaaac gttgcttaca 1887961 aagtgtataa agattacgcg aaacagcgta agcaaggact tgatcctgtg tttaaagcga 1888021 aaaacatccc agggctgaaa aacgctgaaa catgggaaga tgagaaacaa gaagcataat 1888081 ataaatataa aacaaagctg cattcaatag ttgaatgcag ctttttcatt attggaaata 1888141 aatttaattt ttcgactcga atgaaaaatg acgtgtaaag tcccaattca gtccagtttt 1888201 ctttgttcta tatgtgtcat gtgtgtctta ttcattggag gtagagcaaa ttgacaggct 1888261 tttaaacctc cccaaaacaa gaaattaggt tgatagacaa tcatgagaaa gatttttaca 1888321 atgagttcgt gctcataaga agtgtagagc caaaatgatg cgaaggagga aaagatcaga 1888381 tatgaaacgg tcaatctcta tttttattac gtgtttattg attacgttat tgacaatggg 1888441 cggcatgata gcttcgccgg catcagcagc agggacaaaa acgccagtag ccaagaatgg 1888501 ccagcttagc ataaaaggta cacagctcgt taaccgagac ggtaaagcgg tacagctgaa 1888561 ggggatcagt tcacacggat tgcaatggta tggagaatat gtcaataaag acagcttaaa 1888621 atggctgaga gatgattggg gtatcaccgt tttccgtgca gcgatgtata cggcagatgg 1888681 cggttatatt gacaacccgt ccgtgaaaaa taaagtaaaa gaagcggttg aagcggcaaa 1888741 agagcttggg atatatgtca tcattgactg gcatatctta aatgacggta atccaaacca 1888801 aaataaagag aaggcaaaag aattcttcaa ggaaatgtca agcctttacg gaaacacgcc 1888861 aaacgtcatt tatgaaattg caaacgaacc aaacggtgat gtgaactgga agcgtgatat 1888921 taaaccatat gcggaagaag tgatttcagt tatccgcaaa aatgatccag acaacatcat 1888981 cattgtcgga accggtacat ggagccagga tgtgaatgat gctgccgatg accagctaaa 1889041 agatgcaaac gttatgtacg cacttcattt ttatgccggc acacacggcc aatttttacg 1889101 ggataaagca aactatgcac tcagcaaagg agcacctatt tttgtgacag agtggggaac 1889161 aagcgacgcg tctggcaatg gcggtgtatt ccttgatcaa tcgagggaat ggctgaaata 1889221 tctcgacagc aagaccatta gctgggtgaa ctggaatctt tctgataagc aggaatcatc 1889281 ctcagcttta aagccggggg catctaaaac aggcggctgg cggttgtcag atttatctgc 1889341 ttcaggaaca ttcgttagag aaaacattct cggcaccaaa gattcgacga aggacattcc 1889401 tgaaacgcca tcaaaagata aacccacaca ggaaaatggt atttctgtac agtacagagc 1889461 aggggatggg agtatgaaca gcaaccaaat ccgtccgcag cttcaaataa aaaataacgg 1889521 caataccacg gttgatttaa aagatgtcac tgcccgttac tggtataaag cgaaaaacaa 1889581 aggccaaaac tttgactgtg actacgcgca gattggatgc ggcaatgtga cacacaagtt 1889641 tgtgacgttg cataaaccaa agcaaggtgc agatacctat ctggaacttg gatttaaaaa 1889701 cggaacgttg gcaccgggag caagcacagg gaatattcag ctccgtcttc acaatgatga 1889761 ctggagcaat tatgcacaaa gcggcgatta ttcctttttc aaatcaaata cgtttaaaac 1889821 aacgaaaaaa atcacattat atgatcaagg aaaactgatt tggggaacag aaccaaatta 1889881 gttaagcttt tttttggcgg acatcagtaa cgatgtccgt ttttatcatc taataggagg 1889941 tttgcgttgt ggatgaaata ctgaaacagt atatggtgct gtataaaaaa atgagtaata 1890001 tgataaatgg tcccgactat ccaggtaagg aaaaagacat ccagcatcaa aaagatcaga 1890061 tcgaagttta cgaaaaacag ctgcagcaag gattttctac agattatgac tatgatgtgt 1890121 ttgctgattc tgttatcaaa tgcgcatatg gcgatatgac gctggaagat ttagaagccg 1890181 tttattatgg attgacaaca ccattttttt gatttgtcat tcagcagtaa aatttcaatt 1890241 tctgtctcac taacttaagt atactttgat attgagacag aaatttattt attttgttta 1890301 cttcctagaa tatatattat gtaaactaga aaagatgaag aataaagctt tgctgttttt 1890361 atgtacatcc tttcttcttc ctgtaattca gcaacaaaat aaaaaagcga tttcccaatc 1890421 ggaaaatcgc caattcagac actctattat ttatgtgtgt ctttgtgctc ttaacgattt 1890481 acaacaaatg ttgtcacgct ttgagctgga agatgagccc aaaaatgatt gcctgataca 1890541 gtgagattcg ttccaggttg tagattgctg ctgctgctcg tgatccatct agatacgttt 1890601 gaagcagatc cattctgcaa aacaaagttt tggttgactc ctgtgttgct tttattgatg 1890661 gcaacaataa cgaccttgtt gtcaccttta taggctgaca cgtaaacgtt cgcattaggg 1890721 tttttcgttg catcaatcct tacatagccg ggacgcacaa actttgagaa atgagccata 1890781 ttgtagccgc gtttgctgat cgtaccatct tctttcatag gtccatatga tcttcggatg 1890841 taccaccata cataagcttg aaagtccccc tctaccatcg cattgtgaat atgctgtgaa 1890901 acatccaatg cctcaggcca tcgatccgcc gagttggtat cactgtttgg atagtatact 1890961 tccgtcatcc aaaggtcctt ccccgctcct ttttgtttga aaagaggata agggaattgg 1891021 ctgacctggg tgccgtacag gtgagttccg agaatatcca tattggcaag agcctgcgga 1891081 tcgttcaaga tcgggtccga caaattcttc aagtattgaa atgactcagg cgcaatgacg 1891141 cgggcattga tcgagccggc gttttctctc ataaagcgaa gtatttcttg cggcgtccac 1891201 cacgtccact cgtgagcgta atcaggctcg ttttggaccg aaatcgcgta aagattcaca 1891261 ccattattct tcatgaaggt aacaaaatcg ttaagatgct gcgcgtatgc tgcgtacttg 1891321 ttgtatttca gccgtttagc cgatgtgtca ccattccgat taaaggtctc aaccatatca 1891381 cttggaggat tccaaggaga agcaaaaacg attgctccgt gtttgaccgc actctttgca 1891441 gtctccacct ctttatacca attatttcga ttttcatcta catgaattct taagattgaa 1891501 aatcctaact ggttctgtcc attgccaaaa gcagtttctc tttgagctgc tgtaagatcc 1891561 ccagcccaag ccggatgatt catccctcca aaaccgcgaa tcacttgttt ctctgcagat 1891621 acattaactg ttacatcact tgctgccaaa acttcagtag cgcctggccc taacatgact 1891681 gacagcatag tgaaacatac taatagtaca caaattgttt tttttatgcg tggaatcatt 1891741 tattcctctc cttcgtcatg tgtcttttac ggtattaaaa aatctgcatg gcatatccat 1891801 aatggcgggc tgttccggtg ctggcccgta cttcacccgc ctcgttttta agcggtccca 1891861 ttacgagtac tatctttgcg taaactgcca gtaatcaaaa ttaaacaagt ttcctgtacc 1891921 tgttccggta aatacaaaga atactttgtg cacaccggtt gccccgctta ccgcagtttc 1891981 tatttccctc cacgtttgcg ctccgcctgt tgaaggcaca ttcagagttc caacaagctt 1892041 accgtctgca ctgtcgaggc gcacttctat tttcccgcct aaagtggatg ctacatttgc 1892101 tttaaatgac ctggcaccgc ccgctccgaa gtctgcattt cctacagcaa tccagtctcc 1892161 attttgaatg cttgttacat gctgattatt tactggcccg ccgggtgctg tggacttctc 1892221 tgtcaaaatg cgtccattcc aagcaaacgt ttcagcttct acccggttat atgggtttaa 1892281 attggaaatt tgtgttacac ctgcataatt tgccgctacc tcttgaatag atccatctgc 1892341 attatgcacc agcttattaa tatggggaga gcggtatcct ttgccggccc cgaacagagc 1892401 ggaactgaca gtttgcgcat ggtacaccac ataccactcg tttttaaaat tgaaaacagc 1892461 atgatggttg tttccgccac ctccgaaaaa tgcacccgga tttttcagga agtgccctct 1892521 atatgtaaag ggacccatgg gacttgaact ggtcatgtag ccgatctcac ccgggggttt 1892581 atcggccggg tgcgtgccgc cgaaattgat gcaataggag taataatatg ttccgttata 1892641 cttgtgcaat cccgaatctt caaacatgaa aggcgcatca attgtagatg cacttccaac 1892701 aacactcgtc atatcaggcc ccaattttat gactctagcc gttttaggat tggcccattg 1892761 tccctgcgtt ggatttgaaa cgccaggaac gcctccgccg gcatacaggt aaccggttcc 1892821 gtcgtcatct acaaatactg ccggatcaaa aagccataca acaccagaca ttcctggcgt 1892881 acttggcgtt acgagcggtt ttccgattgg gtcggtccat ggaccaatcg ggctgtctgc 1892941 ggtgagaacc ccgatacctc cgccgctgtt tgcgaaataa aggaagaatt tatccttgcc 1893001 attaattttt ttaactgcga ttgacggtgc ccatgacgca cctgcccatt ttgcaattcc 1893061 acggcctcca ttagctccat tggcacctgc taccggaatg gctccgtggt ctgtccagtt 1893121 caccatatcc gctgaagata tgacgaatac tctattcaaa ttggcaaatg aattatcttt 1893181 aattgttccg ttgctattat attcatagtc atcacttgac atatagatgt agactcttcc 1893241 gttataggtc agcgcaaccg gatccgctcc caaatgatgg tcgataagcg gatttgaatt 1893301 ccctatatgt tttgcaattg tagtactagt ggcagcatac gcagacttcc cagataagca 1893361 gctcaataat aaaactagaa tccataaaca tacgctacac tttttcctca tcacttcaca 1893421 tcctcctttt tccttaaaat gggggatttt cttttggaat ttgataacaa caggtcacga 1893481 agattgcacg cataaagtag ccggaagctg tttagcaatg ttcccagttg ttctgaaagc 1893541 tcatcttcat gtgtctccat tctctctttt cttcgaggag atcgcaccac tccttcaaaa 1893601 ttgttcaaaa aaacttcccc attcctagcg accattgtcc agaaaataaa aagacaggat 1893661 tgttcatggc ctcccactaa tcacattgaa cggagattac atcattatcc aagatatccc 1893721 tttatctaac atcctacatc attaaaaaaa ttgtgtatag aaacttttgg aggagttagt 1893781 gttcgattct acaaaggaac tggatacatt tattcattga taagatgggg ctaacactcc 1893841 gtttatattt gtatgttttc agacacaaaa aacagccgtt caatgcggct gtttttttca 1893901 agagtataag actattgagc ggtatacccg ctttttcatg ttttgttcat attttattaa 1893961 ttgtttattc aacactgtcc gctatagtaa tccatatcaa caaatatgac tgccactcgc 1894021 atcttttatg aagggaggtt cgttacgctg aaagaaaaaa taaagacatt aggccgtttt 1894081 tgcaccgtag gcgtcggcaa tacgctgata gattttggtg tcttctttct tcttaccgct 1894141 tgtcatgtct cttatctgcc ggcgcagatc tgctcctata ctgcaggtat cgtcaacagc 1894201 tatgtgtgga accggaattg gacgttttgt gtgaaacgta aggctgacgg gaaagagatc 1894261 gtgcgttttc tcatgattaa tattgccgcg tcagggatca cctttttgct gctttatttg 1894321 tttcaaaatt gcggctgctc gcttttggtg agtaagctcg ccgccactat cggcggaatg 1894381 atgatgaatt ttatcggaaa ccgaatctgg gtatttggag attcgctgaa aaacatacag 1894441 gatcaggagt gaagatgaat gagaaaaaaa gtgagaaaag cggttatacc cgcagcgggt 1894501 ttaggaacga gatttctgcc ggcgacaaag gcgcagccta aagaaatgct tccaatcgtc 1894561 gacaaaccag caatccaata tattgtagaa gaggccgcag agtcaggaat tgaagatata 1894621 ctgattatta cagggagaaa caaacgctcg attgaagatc attttgatcg gtcggcggaa 1894681 ttggaattca atctccggga aaaaggcaag acggagacac ttaaggaaat gcagcagatt 1894741 gccgatttgg ccaacattca ttacatccgc cagaaagaac cgctcggatt aggccatgcg 1894801 gtgctgtgtg cggagcattt tatcggagat gagccttttg ctgttctctt aggtgatgat 1894861 attatggtgt ctgaaacacc ggctcttcgg caattaatgg atgtatatga cgtttatggc 1894921 acagaggttg tcggtgtaca gtcagttctc cctgaggatg tcagcaaata tggtattata 1894981 aatacatcag ggtctcaagg gcatgtatat gaagtgaacg atttagtgga aaagccttct 1895041 cctgaagaag caccttcgga aatcgcagta atgggacgtt atgtgctgaa ttcttcgatc 1895101 ttctccgttt tgaagacaat tggcagaggc gcgggcaacg aaattcagct gacagatgcg 1895161 cttcgtgagg tttgccgtaa ggagccgatc catgcccggc tgctggaagg aaatcgatat 1895221 gacattggcg ataagctggg ctgttttaaa gcgagcaccg aaatcggctt aatgcgtccc 1895281 gaaatgagat ctcagctttt ggcctattta gaagatgtga tcaaacggga aacgaaagaa 1895341 atgctgcggt aaaaaaattg taaccatctt gctcgtcaat cagtcatata atagtgaaaa 1895401 agattaggac aggttgtgaa gaatgtgggc agtttgataa gcgaaatttt aacatggctg 1895461 acgaacatgg gatatgcggg tattgcgatt gggttaatga ttgaaatcat tccgagtgag 1895521 attgtattag cttatggcgg ctatatggta tcggagggca cgattggatt tattggcgca 1895581 attattgcgg gtgttatcgg gggcaccatt gcccagatct ttatttactg gatcggtcgc 1895641 tatggcggca ggccatttct ggacaaatac gggaagtatt tattgattaa aaagcatcat 1895701 atcgatatgt cggaaaactg gtttcagaaa tacggcgccg gagttgtctt ctcggctcgt 1895761 tttataccgg ttgtcagaca tgccatatcc attccggcag gtattgccag aatgcctttt 1895821 ctcaaatttg tggtactgac tgtgcttgct atcattccat ggtctatcct gtttgtttat 1895881 ttaggcatac agctaggaag ccagtgggat gatgttgaga atatagcagg cacttataca 1895941 acaccgatta tgatattggc tgttgtcgtg atagcccttt attttgtgat taagaaacgt 1896001 acagccatat ttaaacgata gctagcggat atgcataggg gtgactgacg ctcccctatg 1896061 catatttttt tacttgcgat gttgatttgc cagcttcaga ttctccgcta aaaatgcgac 1896121 aaacacttca tcccgcacga gcgatgcggc ataatttctc ttaataaacc attctgcctc 1896181 ttcaaacgct gcgaatgttt cgtcttgggt ttctccgtta atttgaatat tccattcgtt 1896241 gtctaaaggg aaaagaaaaa atctcatttg tgcgcgattt tcatataatg atccattcgc 1896301 agatcccttt agattataga tgttacggaa ggcatccggc cgtacaggat caatacggaa 1896361 agcttcagct acaaacaact cgtatacttc atcggttatt gaacagccgg acgcttttgc 1896421 atgccctccg ccgccatatc ggccggcgat ttctgacaca tcgatgtaat catgaatggt 1896481 gcggagactg actcgttttg accccatgct caaaatcgca atgtaatcga ggtgcgggtt 1896541 atctttccct agcctgttcc ccagctctga atggtacgat tcagcgtgaa cgatgcctac 1896601 acagtgttcg tgaacaaagg tttgtaccat ttcccttttc tttctgcgga ggtagcgctc 1896661 gattttttcg tcttctaaat caagcagttt ttcttcaaaa tcatcgaaga aaaattcgtc 1896721 atgcgtggaa aggcgctgga tcatttttgc ttcaaattca tcgattgaca gcaaaaagaa 1896781 aagatcatta agccgcttcg cctgtttttg atcgtaccgc tcccactccc atgtatcgta 1896841 ttggcggacg agctctgtga attgatctaa ggcgtttgtc ggtttcatga agccattttc 1896901 aatgagatag ccatataaaa gcgatgtcgc ggatgtgagc cttccatcat cgtattccac 1896961 ctggacaaat ccccattcat gctcattcaa atgaagggct gttttatgat ggtcaatgag 1897021 cttcactttg ccccctgcat gaacatactc attcaatctc tcttcgtttt cttcattgac 1897081 ggcgagatcg gtgatgaata acgcgtcctg tctgttgctc tccttcgctt tttctaaaaa 1897141 gtactgcacc tgtgcgttta agccgttgac agagttatac cggatctcta cgtcttttcc 1897201 gaacgccaat tttgctacga ttccgcatcc tactccgtcc aagtcgttat gtgaatataa 1897261 atgatacata atgtaggccc ctttttatga taaactgaca attgccgcta gaggtgcggc 1897321 agcctttatt tactattcta aaaaaccaag cgttttatgc aatggtaatt agttgacata 1897381 atgttgttat tgtaaatata taaaggagcg ctttttttgc gctcctaagt tcttgctttt 1897441 acaccggata aaccggatgc tttcgattgg taaatgtcat ttcctttgtc atgtatgcct 1897501 tgagccgttt ggccagctca tcacgcagcg aattggctgg gataacagca tcaatgatca 1897561 tttctgaagc cagacggtag atattgatgt cctctttgta ttcctcccgt ttgctgctga 1897621 taaatgcggc tctctcttct tctggcagct cggcgatttt tttagcgtag acagcgttta 1897681 cagcggcctc agggcccatg acggcgattt gggcggttgg gagcgctaga cagcaatccg 1897741 gttcaaatgc cggccctgcc attgcataca accccgcccc gtaagctttt cggacaatga 1897801 cagagagttt tggaacagtt gcctccgaca tcgcagaaat cattttcgct ccgtgtctga 1897861 taatcccagc ctgttctact tttgtgccaa tcataaaacc ggggatatcg gctaagaaca 1897921 gcaatgggat atgaaaagcg tcacataagg taataaactt agccgctttg tctgctgaat 1897981 cgtggaataa gacgcctcct tttaccttcg gctggtttgc aacaatgccg acaggctgtc 1898041 cgtggattcg tgcgaggccc gtcaataatt ccggtgcaaa taaggctttg atctcaaaaa 1898101 atgagtcttc atctatgacc cgctcaatga gctcatgcat atcaaaaggt gcgttttgat 1898161 tttgcggaat gacgtcggca agcggagttt cgaagtgttt tggcgggcgt ttctcatgaa 1898221 tgggcgcttt ttcttgaaaa tttgccggaa agtaagacaa ataagcccgc accagctgta 1898281 tggcttcttc ttcagtttct gcaagaatat ctccgcagcc ggagattgag caatgcatac 1898341 gggcgccacc catttcttcg agagacactt tttctccaat aaccatttcc gccatccttg 1898401 gcgaacctaa atacatggag gcgttaccgt ctaccataac gacgatatca cagaaggccg 1898461 gaatataagc gcctcctgcc gcagatggtc cgaaaagcag acagatttgc ggaatgcgtc 1898521 ccgataattt gacttgattg taaaaaattc ttcctgcacc gcgtctccct ggaaagacat 1898581 tgatttggtc ggtaattcgg gcgcctgccg aatcgactaa ataaatgagc ggacagttta 1898641 atttttcggc gatttcttga attctgatga ttttttcaac tgtttttgct ccccatgacc 1898701 ccgctttcac tgttgaatca ttcgccatga cgcaaacggt ttggccgccg attttgccga 1898761 tagcggttac aactccgtca gcgggaagcc cgtctgacat acattccgca aaaaaagcgt 1898821 cttctagctc aatgtcatcg tcaaagagaa gggaaagccg ctctctgaca aagagcttgc 1898881 ctttttcccg attgctttga tgatactttt ccgctccgcc ttttcgaatc cgttcagccc 1898941 gttctgttcg ttccttttca taatccatca gcattgcctc ccttttatat tcccttgtat 1899001 acggcccgtc ttttttcttg aaaggcctga agcccttctc tcctgtcttt tgtcgggatg 1899061 gtttgttcat acgctttttg ttcaatcgca aggcctgtag caagatctgt ctccaatcct 1899121 ttattgattg caaatttagc ctgacggaca gcgatcggtc cgttggcaga aatggctgcg 1899181 gccagttcct ctgcttttgg cataaggtca caaggagccg tgacatgctc tacaaggccg 1899241 atttcttttg cttcgtgtgc ggtcacgcgt ctgcctgtat aaatgaattc ttttgctttt 1899301 cctctgccaa tcagccgggg cagcctttgg gtccctccag cgcccgggat aatagctaac 1899361 cctgtttccg gaagtcccag cacagctgct tcagttgcga ttcgaaggtc gcatgccaat 1899421 gccaattcta gtccgccgcc taatgcgctt ccatttatcg cagctatgac cggctgcggc 1899481 aaggcatcaa gtaaagccgc cgttctttga atgagagata cactttccag aacctgatct 1899541 tctttcagtt ttatccgttc cttcaggtct gcccctgcac aaaacgcttt ttcaccggtg 1899601 cctgtgagga tgacgcaacg gatgtttgag ttaaattcaa tttcctggat aatcatttgc 1899661 aggtttctaa gcatttccgc tgaaagagca tttgctgcct gaggcctgtt taaggtgatc 1899721 aacgccatat gttcattttt aacagtaaaa agaatagaat ctcccattgt atgcgtcctc 1899781 ccttttatca agatgattta aacacctgta aatttctgct cggcagcggt ttgcccattt 1899841 tttcttcaat ccatttggcc gcagatagca gtttttctag ctttacattt gttttgatat 1899901 ccatctgttc aagcatgtac acgatatcct cagttgcggc gtttcctgat gaacctggcg 1899961 catatgggca tcccccaagc ccgcctgccg agccgtcgaa caccgtgatg cccatttgga 1900021 gtgctgtgac catgttggcc agagcggttc ctctcgtatc atgaaaatgc agggcaattt 1900081 gattagccgg gaatcgtgcc aaaagagctt caagtacagt ttccacttgg gcgggattag 1900141 ctgctccaat cgtatctcca agcgacagtt cagaaatccc aaattcaaat agagcttctg 1900201 aaaggcgaat gacttgttca atggggacat ctttttcgta cggacagccg aaaacagtcg 1900261 agaggtaggc tcttgttgtg aggtttgctt tttgtgcgtc gttgtttact tgtttgagta 1900321 tatggaggga ttcagaagtg gatttattga tgttttttct gttgtgcgtc tcgctggcgg 1900381 acataaaaac gcaagcctcg ttaatgcctc cttcaagtgc attctccagt cctctttgat 1900441 tcgggacaag tgccgcgtac gttacccctt tttctcggtc gatgcctttt gctacatcga 1900501 tagcatctcg aagcgccgga atccatttcg ggtgaacgaa ggatgtgatt tcaatatacg 1900561 acagccctgt ccgggaaagc tggttgatcc aggttatttt atcctctgtt gcgatccaaa 1900621 cgggctcgtt ttgtaagcca tcacgcgggc cgacttcttt gattgtcact tttttaggat 1900681 atggcatggt cttcctccaa attattgagt ggaattgctc agttcgagca gtacgtctcc 1900741 ttcatttaca aagtcgcctt cctttttttt gacttctttt acgattccgc ttctatctgc 1900801 aacgatcggg atttccattt tcatcgattc caaaatggct acctcctggc ccttttcgat 1900861 ttggtcgccg gctttgacgt ggactttcca caggtttcct gccatttgta tgctaaccgt 1900921 catgacaact gcctccttta taggtgctgt ttcaaaaagt cagtcgtgac atccccttct 1900981 ttaaatgcct ttgttgccgc agcctgtatg aggagcggaa ggtttgtttt gattccctct 1901041 acacgatagt cgcgaagcgc tgtctctagt ttttcaattg cttctgttct ggtttggcct 1901101 ttgacaatca tcttagcgat catcgggtca taaaaagggg taacggtgct gtcttttgct 1901161 accgcacatt cgtgtctgac tcctttttgg tcaggaagtg aaaacgcagt gatcgtacct 1901221 ggtgacggga agaaggtctt gggatcttcc gcgtatattc gaacctctat cgcatgcccg 1901281 ttccgttgga tgtctttttg ggagaatgtg agtgtatggc ccgcagcaat ccgcagctgc 1901341 tgctcaacta agtccaggcc tgttatttct tcagtcacgg ggtgttcaac ttgcagtctc 1901401 gtattcattt cgaggaaata aaaattttgt ttctggtcaa ctataaattc gatggtgcct 1901461 gcgttcgtat agccgattgc cttcgctgct tttaccgctg tttgaccgat cttcattctt 1901521 agttcatcgt ctacaaatgg agacggtgct tcttcaatga ctttttggtg gcgcctctga 1901581 acagagcaat cacgttcaaa cagatgtact gtatggccgt gttgatcggc caaaagctga 1901641 acctcgatgt ggcgcgcatg ttcaataact ttttctatat acatagaccc gtcaccgaaa 1901701 aaatctgctg cgcgcttttt gtttccctcg tacgcttttt ttaatgcttc ttcattttca 1901761 acacgctgca ttccgatgcc gcctccgccc gctgaagctt tcagcatgac aggatagccg 1901821 atttgacttg cggtgcggca ggctgcctct atatctccga gggattcaga aacgcccggc 1901881 accacaggga cacctgcagc ctccattgct tttcgcgctt caattttgct gcccatcttt 1901941 gcgatgatat caggggaagg tccgataaac acgatgtttt cttgcttgca gcgttcagcg 1902001 aaccggctgt tttctgataa caatccatat cccgggtgga tcgcgtcggc ttttgctttt 1902061 ttcgccgtct ttatgattct ctctatattt aaataacttt cactgactct cgattccccg 1902121 atcaaatatg cctctgtagc ggcttttgta tggggcgcgt ccttgtctgc ttctgaataa 1902181 acagcgaccg ttttaatgcc gagacggctg catgttcgga taattctcat tgcaatttca 1902241 ccgcggttgg cgatcagtac ttttgtaaac atgatttcac ctcattgact tgatgataag 1902301 ttgaacattt caatcgtttt ttctcgcagt ttatattttt gaattttgcc tgaggccgtc 1902361 atcggatagt catccgtaaa aataacataa cgcggaattt tgtggcgggc gattttccct 1902421 ttgcaatagg ctttaagctc atcaggtgaa acgcttttac cgtctttcag tttaatccag 1902481 gctgcagctt cctccccgaa tttggcgtca ggcacaccaa ccacctgtac atctaaaaca 1902541 gcgggatgct ggtataaaaa ttcttcaatt tcccgcggat aaatgttctc gccgcctctg 1902601 atgagcatat cttttaatct tccggtgatg cggcagtacc cgtcttcatc catgacagca 1902661 agatctccgg taaacagcca tccgtcatga ttgattgctt ttctggtcgc atctttgtct 1902721 ttataatagc ctttcatgac gtgatagcca cgggtgcaca gttctccctg catgcctctt 1902781 tgaacttctt gacatgtccc gggttctaca attttcacct cagtatgtgg cagggcacgg 1902841 ccggttgttt cgactcttct tatgaaggaa tcatttgctc tcgtttgtgt aatgactggc 1902901 gaggcttcgg tttgtccata ggcgatcgta atgtctttca tgcccatcct ttcaatcaca 1902961 gctttcatca cttcacttgg acagggagag ccggccatga ttcctgttcg gagcgtcgat 1903021 agatcatatg catcaaaatc cggatgatgc agctcggcga taaacatggt aggcacacca 1903081 tggagcactg tgcatttctc tttttctacc gttttaagga cggtaacggg atcaaattct 1903141 tgcacgggta tcatggctgc cccgacggat acacatgcca aaaccccaag gacgcatcca 1903201 aagcagtgaa aaaacggaac agggatgcac atgcggtctt gagaggttaa agccatacat 1903261 tcagcgatat tagcagcgtt attgatgaca ttgaaatggg tcagcatcac gccttttgga 1903321 aaccctgtcg ttcctgatgt gtattgcata ttaatcacat tgtctttatc caggctgttc 1903381 attctctctt caagctcagc atctgtcact gttttcgcca atatctctgt atcgtcccaa 1903441 tgatacatgc cagacaatcg tttattgcca atatagatca gcgtttttaa aaagggatag 1903501 cgttcagatt tcagttggcc gggctttgct tcttgcagtt ctggaattaa actgttcacg 1903561 atgtctggat aagaagtgcc cctgtatgaa tccatgataa taagcgccgc ggcatccgat 1903621 tgctttaaca agtaatcaag ctcatgtgct tgataattgg tattgacggt cacgagcacg 1903681 gctccgatct tcgcagttgc gaactggacg gcaagccatt cagagatatt agaagcccat 1903741 atggcgacgt ggtctccttt tccaatcccc atccgcatga gacctttagc ggtttgacgg 1903801 cacagactgt caaattgagc gtacgtatag cggatatttc ggtctggata cacaacagca 1903861 tctcgatcgg gatacgcatc agctgtttgt tccagcagcc tgccgattgt ggaatggatg 1903921 agttcagcca ttcattgttc ctcctttctt aatgatagga aagcgtttac atttttattt 1903981 taaaagctgt ctggcgatca cgagacgctg aatttcagat gtgccttcac cgatttccat 1904041 taattttgcg tcccgcagca tccgttccac cccatactct ttcatatagc ctgaacctcc 1904101 atggatttga atggcttgat tgcaagctct tgtcgccatt tcagatgcga atagcttggc 1904161 gtacgccgct tctttggtga acgggcggtt atgatctttc agccaggcgg cttttaacac 1904221 catttgccgt gccagatcaa tttccatcgc catgtcagca agcttaaatt gaatcgcttg 1904281 aaaggaagaa atcggctgtc caaactgctt tcgctctttc gcatatgcca atgatgcgtc 1904341 aagggccgct tgggcaatgc cgactgcaag agcagcgatg gagattcgac caccatccag 1904401 cgtatataga aactgtttaa acccttttgt tggatcgcca agtaagttgg ccgcaggcac 1904461 tcttacatct tcaagcaaga tttccgctgt attcgaaccg cggacgccca ttttatcgta 1904521 cgggctcgta atcgtaagtc ctggtgtgtc agttggcacg attaatgcgg agatgatgtt 1904581 ttttccgtct ttgtttttgc ctgttacggc ggttacaata actgtgcgtg cgtagcttgc 1904641 attagtgatc cagcactttt cgccgttgat tacatactcg tcaccatttg aaatcgcttt 1904701 tgtttgagtg cctcctgcat ctgagccggc atttggctcc gtcaggccga atgatccgag 1904761 tgctgtgcct gaagccagcg gcgtcaaatg cgtctgtttt tgctcttctg ttccgaagta 1904821 gtaaagaggg cttgcgccta gcgagaccgc tgcagcatag cttaatccag tactgccgca 1904881 ggctttgccg acttcttcaa ccgctaaggc atatgaaatc gtatcaccgc cagatccgcc 1904941 gtattcttct ggaaatggaa tacccatcag accgagttca cccatttttt taaatgtttg 1905001 catcgggaac tcgcctgttt gatctacatg ttcagcgtga ggagcaattt cttttttcgc 1905061 aaaatctttt accatttcac gcaccatttg ttgttctttt gtcagctcaa aattcacatc 1905121 gtttcctcct tcacatcttt gtaacatcct attaggcgag ttctataatc attccctgac 1905181 aagaaaagtc tgaaaattaa aactgaatca ttttttatgt gataatatca gcgggatgag 1905241 caaatacatg cagtaggcgc ataccatcca tatcgtaaac gcaataactt ggccctttga 1905301 taaagccggg aagatgaggg gaagattcca aagggaaatc gtatccatca ataaaccgac 1905361 cgctgatccc catataccta gcttgatcac cgcgaactgt gattgatcga gtttttgata 1905421 gagaaagaac acaaggcata aaacaagagc agtgcccgct cccaagagaa gaaagttcgg 1905481 caaaaaggct tcttcagccg gatcagtcaa cacagcatct ccgaacagca caaaaaataa 1905541 tgtggcacct aaccagacta gaaatgaaaa cgtaaaacac gtcctgtacg tgtttctctt 1905601 cgattttatt tttatttagt actagtttct cagattccaa taatggtaaa tgtccaaaca 1905661 ccgcctccat attcatgtga atctcacctt tgttttttaa aaaattcagc ggtttaccat 1905721 cgtttcctgt cccaaaatca ctttttaaaa aaagacgact tagaaagccg tccttctcat 1905781 ttcttatttt gttgttcgtt tggaagcttt gctttcgtta tgaagccggt ctgctgaagt 1905841 gacataatac gtatatttct tgttgggatc tgccgtgtta tctaagaagg tttgctgctc 1905901 atgtgttttt ctttgcgttg ccagcaatgt tctctgcttt ttcccttcgg ctctgtatat 1905961 cgcataatag gctgtttctt tcgttttttg atttgatggg tgatctttaa tctgcagaag 1906021 attgccgttt ttgtcttcgg tgactttcgt aagcttcggt ttttttgggg cggtattgtc 1906081 aagccaaggc atttgcggaa ccagtgccgg cttgctgtaa agatcggtgc tgagactgtc 1906141 tttgatgcca agcggatttt tgttgaggtc cttgaggctg aaatgcatgc ttcctttcac 1906201 cagttcaagc tggcggttca aagtgatttg ccgcacatat tcctcaggat cggaccaagg 1906261 cggatcaaaa ttgttattga ttttatatgc tgcctggcca atatataagt gaacaggcct 1906321 atttttgact tcattgctcc accaatcagc cagcacgtcg taagccgctg cgttaaagcc 1906381 gatactccaa taaatttgcg gagcaatata atcgatgtcg ccttcttgga tccaatgcct 1906441 tgtgtctgca tatagatcgt cataatttct gacgcctgct tttgtattcg atccggtcgg 1906501 gtcatctgcg gcgtttctcc atactccaaa gggactgatg ccgaatttga catacggttt 1906561 tgcagcttta attgtttggt tgatttgttt gacaagctgg ttcacattgt cccgccgcca 1906621 gtcatcgata ttagaaaaag cgtcttttcc gtattgttcg tactgtgctt gatcaggaaa 1906681 ttcctgtccc gctattttat aagggtaaaa ataatcatcc atatgaacag catcgatatc 1906741 ataatgtttt acgacttctt caatgccttt gacgataaaa tctctcgctt ctggaatgcc 1906801 tggatgataa tacagctggt ttccataggc ggcaacccaa tctggatgtt ttcttgccgg 1906861 gtgatcctca gacaatttat taagatctgt atgattcatt gtaatacggt aaggattaaa 1906921 ccacgcgtga aattccaaat ttcgtttatg ggtttcttca atcataaatg caagaggatc 1906981 atagccgggg tccttccctt ggacaccggt taagtattcc gaccaaggcc cgtaagctga 1907041 cggataaaag gcatcagccg tcggtttaat ctgaacgata acggcattca ttcccatttt 1907101 ttgcacatcg tccagcagtt tgatatactc ctgtttttgc tctttcacag ataacccttt 1907161 tttggacggc caatcaatat ttaatacgga agcaatccat acggctctca gctccctgtc 1907221 agactgcgca ttggccataa acggaacgga aatgacaaac gttccgatga tcaagctgac 1907281 aaggaaacgg acaatcgact tttggcaaac cttcattctg tttcttctcc cccattacat 1907341 cactttcact attcgctatt acggtattcc cgggctataa aagggtgatt aacagaatgt 1907401 ctatctcact aaataaacga aaaaagtcct aaagcatgtt gtgaaccgct tttaggactt 1907461 tttatcattc atcatggttt gcagactttt taacacatca ataagtttta cgccgacacc 1907521 gacagccgtt tcaaggatcg cttgtgctcc ggcaatggct aaaataaaga tcagcggtat 1907581 tgcaatacga ggcaaaaaaa gatagccaag tccgatcaag atggcacacc aaacaccggc 1907641 acaccagtag caattgagca tgtatccaaa gttagaagcc ggcacgcttt tttcatctac 1907701 atgcccgttt tgatcaacaa tccttttctt tttcataaaa ggttttcgga taaattctgt 1907761 gattttgtca aatacaatca aatgtgtcag cctgtaactg gctagaatca gcatgataaa 1907821 agttagaaaa gaaagacggt ccattgagaa gcctccaaga aaaaggatga tgttatcatt 1907881 cccaagtgtc ccttatccat tcttgataca aaaagaaaga cggacagaga atggcctctg 1907941 tccgctaatc cgctttatcg tttgtgcagt attacttgat ttgaagtgat cttttctaaa 1908001 atgtcgagga tgatgtcggc attcttttca gcatatgttc cttccagcat gtctttatga 1908061 gcgccaaaac ccgtgtactc actatagttt ccgcaggcgc cttcccattt cgttaagcct 1908121 gtatgcccgc tggtttcggg gtggattcca gcttcgatga aatgaatgct tgctttgatg 1908181 tggccttcat tcagcaattg tgcccaatat tcctgatagt ttcttttttt cttcatcacc 1908241 ttttctctga ctgcttcagg cagatatgct gcagattcgt cattaccggt atcgataggc 1908301 aaaggctgtt cttttagata agcgtccacg ataatgaagt cgctgacttc taatcctttg 1908361 cgctccatag cctgtgccac ttcaaaagcc aggtttccgc ctgcagagta gcctaataaa 1908421 acgtatgggc cctcaggctg tatgtccgtc atgcaattaa catattgttc aatgcgggtg 1908481 tcttgttcaa taaagtgaaa cccgtatacg gctgccttct cattcagcaa taaagcaagg 1908541 tctttaaaat aaatgccaaa tcccgatatc ggcgggaagc agaaaagatt ttgcgcgccg 1908601 tgctggttca gtttgatcac atgctgttca tttgctgctg tcagctgttt agaataaagt 1908661 ttttcggcaa gctgagcgat tgtcggatgt tcgaacaaga aatcaatcgg tatgtcaatg 1908721 ttctgctgat gttttagtgt atgtatgact tgcagtgctc ttagtgaatg tccgccaata 1908781 gcaaagaagt catcatcaat actgattgtg ttaacaccga ggacttgctt ccaaatgttc 1908841 gccaattctt cttcaaccaa gtttcttggc aatatgatgt tctgtcgttt ggcaggctta 1908901 ttttctggaa taggcagcgc gctgcggtct atttttccgt ttccggtaag cggcatccgc 1908961 tccacacgca cccagtgctg cgggatcata tagtctggaa gcacacgcgc caaatcggcg 1909021 cgaaaatccg tatctgtttt tttgtgatca ccgacgtaat gagtgtacag ctgcgcctct 1909081 ccatcttttt ctctcaatgt cactgctgct tcttgaacgc cttccatttc taacaggcgc 1909141 gcttctattt cggcaggctc aattcgtttt ccgcggattt tcatttgcct gtcaattctg 1909201 ctgatgtatt ctaagtttcc atcaggcagc cagcgcgcca aatcaccagt acggtatatt 1909261 ctttctccag gcaagaaagg atgaggagaa aacacagcat ttgtcagatc tactctgttc 1909321 aaatagcctt tagcgactcc atcaccgcca acacaaagct cgccgggaac gcctattggc 1909381 aaaagacgtc cttttgtatc taagatgtaa gcggtgctat tactgattgg ttttccaatc 1909441 ggaatcggcc ccgcatagtc tctcttcatt tcaaaaaagg ttgaaaaagt cgtgttttcc 1909501 gttggcccgt aaatattatg aagcgcgaga tctggacagg cgtgtctgac ggcattcatc 1909561 agggcaggag agagtgcttc tcctccgaca tataacgtat ggagtccgcg aaacatgtca 1909621 gctcgtacct gtgccagctg attaaaaaga gctgtcgtta aaaatagcac tgtaatgtca 1909681 ttttcaagca aatacgctcc aaaccgatca ggtgtcagca ttgtcgattt atcaatgata 1909741 tgaaggcttg cgccatttaa aagtgccccg aacatttcaa aggtgacggc gtcaaagctg 1909801 atagatccag tcataataaa ccggtcatca ccggacgcag acgtgtaatt gctgtttctg 1909861 acaagggaca cgacattgcg attcgtgatc atgacccctt tcggccggcc tgttgatcct 1909921 gaggtataca tgatgtacgc aagatcatcc gggctggagc tgatattaat agggatatcg 1909981 ttctcttcca tcaatccctg cgcatctgaa atgatacatg ttcctgagaa cgcagcgttt 1910041 tgctccaatc ccttttgaac aatcagcatt tttgcctgcg tttcctcaag cataaagctg 1910101 actcgttcag gcggaagctc cgcatcaagc gggaggtatg ctccccctgc ttttaatacg 1910161 gcaagcacac tgatcatgaa ttcgggagaa tgtgcagcca atattccggc tgtctcgttt 1910221 ttccgaaatc ccttttgaat taactctctg gcgagcgcat tagagcgttt atcaagctct 1910281 ttatacgaaa tagacatatt gccatacaca agtgcggtat ggtctggcgt cttttctgct 1910341 tgttcgcgaa ataaatcgat aattgtatga ttctttggat actccgtttt tgtattgttg 1910401 aactgtgtga caatctgctc tttttctgtt gcatcaagaa aagaaaaatc agcaattggc 1910461 atatgagggt gctgtgcagc tgtgctaagc gcttgcgtaa attgcctctt gatacagctg 1910521 atccaggcag catcgtaaac gaatgcatta tagctgaact tgatgacaag ctcttcgcca 1910581 ggagcaacga caagattaaa gttatatcct gattgctcgg atacttgaac ttgatcgatt 1910641 tgcagcggtg aatcggtttg atcagcggaa tcggcgattt tctgctgtaa cggatagttt 1910701 tcaaagacga taatgtgatc aatcagttcc tgttttaatg cggtgtttgc ctgaatatca 1910761 aataaaggct ggcaggtaaa cggctcagct tccagcattt ctttctggca gcgtatgagc 1910821 agctcgtgaa acgtttcgtc ttggtgtgtt ttaattcgaa tcggtatggt attgataaac 1910881 aaccctatca tttgctccac gcctgggatt tctgacggtc ttcctgatac aactgcgcca 1910941 aacacaacgt cgtctgtgcg gttatattgc tgcagcatca caccccagac tgcctgaata 1911001 agggtagcga gcgtgacgcc gtgttgtttg gcagtctctt tcagcttgtc tgtcagtggt 1911061 ttatttaatg aaaatatcaa atcttcacgg tgataacttt cttttgtttc tttatcagac 1911121 acacgaggca gaggtgatgg agcgctgtag ttttttaaat aggtatccca gtaggccgct 1911181 gctttttctt tgtctcggtt tgtcagccat gaaatatagg tgctgtacgg acggacaggg 1911241 tctaatgaaa gcggttttcc tgcatgaatc gattgataaa tttgcataaa ttcctgcata 1911301 acgataccta ggcaccatcc gtccattaaa atgtgatggt gactccagat acagacatgc 1911361 tcatctttag ctgttttgaa tagagaaatc cgcatcagca tgtctttttg cagatcaaag 1911421 cctttttgct tgtccttctc tttaaagcgt tcaatatact cattctggtc gtttgtcggc 1911481 agatgagaaa tgtcttcgct gttcaaatgg aattcacgtt ctgtcatcac gacttgccga 1911541 ggtcccgaca aatgcgggac gtgcggcaaa aacacggttc tgaaaatatc atggcggtcg 1911601 ataatggctt gaatgctgcg ctggaaccag tcatagctga ggcttccttt aatggtgaag 1911661 agcgactgct caacatacgc cccctcctct ttacggagga aggaatgaaa cagcatccct 1911721 tcctgcatat gactcagagg ataaatgttc ttgatttttt taatggtatt catagtgtct 1911781 gcacctttct tcacggattc attagtgaaa actgagcata tcagcgatct cttgcagggc 1911841 gtcctcggtc agttcttgat catcaaaatc actgatcgtc ttttctgttt cgcttttgtt 1911901 ctggcagtgt tcgatcagct gtaataaaaa ttgacggcat gtttcgctaa gctgttcgat 1911961 ggttttgcgc tgaaagcggg cattgtcata agtcatattg acagtcaatt ttccttctgc 1912021 agcgattgcg ctgatatcca gcgactgttc acggttccat gttgtgctga tatcacctcc 1912081 ggcacccagc ggagagaatg agaaggcgtc ctcctcaggt acttcagctg tgcggccgct 1912141 ttcaaattga ccaagataat taaagctgat ttctggtgca cctgtgaaat tgatgtcttt 1912201 tttgccaggc ggagtcaaat atttgatgac accgtagccg aatcctttgt caggtacacg 1912261 tctcagtgta tcttttgttg tttttagcac atgaaccatg ctttcttccg aatctggcaa 1912321 gtctgcgttc agtttaatca ataacggata aatggcggta aaccatccaa tcgtccggct 1912381 cacatctatt ccttttaata catcctctcg cccgtggccc tctaatgata gtttgaaggc 1912441 ggattgattg gtccaatggc gcagcgcaag aatgacagaa gcgagcagca tgtcctgcgt 1912501 atcagtgtta tatgcgctgt tggcgtcttt taagagtgct gctgtctctt tatcgtttaa 1912561 ggtaaacgaa attgtggacc gttgtccctc gtgtgctcta gttccatcga tttgatcaaa 1912621 aggcaatgcc tctgtttgat actcttcggc ttcgcgccaa tacttgagct gtttcattag 1912681 ctgctggctt tcagcgtagt cagagagctt tttcgcatac gctttaaacg agcttgtttt 1912741 aggcggcagt ttgatatcct ccccgccagc agcttggcga taccctaaag ccaaatcttc 1912801 aagcagaacc cgccatgaga tgccgtcaac gacgaggtga tgagcagata aaaataagaa 1912861 atcaccgtca attgtgtgga aaagaccggc ttgcagcagc ggaccattct tcaaatccat 1912921 tttctgctga atatcaagta catggcgctt gataagaggt tcatacggtc tatttccatc 1912981 agtgccgtcc ggagctgaca aatcaatcat ctgaaggccg tacaacgcgt cgtccgaatg 1913041 actgagcggc cgattatatt gatcccactt tccttgttca ttctgtgtaa acaccattcg 1913101 cagcgcatca tgatgacacg ttattgcttt taacgttttt cgcagtgcgt cttcttgtac 1913161 agaggtgctt cgatgcagca ttacggactg attaaaatgg tgtttttctt ttatatcttg 1913221 agaaagaaac catttttgaa caggcgacca ttgtacgtct ccctcaaccg cagcttggct 1913281 ggaacttgta tctgaatcac ggatataagc tgccaattct tgaatggtcg gatggctaaa 1913341 caaatctttc actgccattt gcttgcctat ccggtgaagc cgcgcagata cctgtaacgc 1913401 tttgattgaa tctccgccaa gttcaaagaa cgaatcagct gttccgatct tttctgcccc 1913461 cagtacttct ttccatatat ctgccagtat ttgttccatt ttgctggatg gcgggaggaa 1913521 tggacgttca ccttcgtggt tgtatacagg ttttggaagt gctccgcgat ccagcttgcc 1913581 gtttggtgac aatggaagtg agtccagttt ttcaataaac gcagggtgca taaacaccgg 1913641 cagcttgttt tgtaattctg agcgtacagc atttgtgctc aaccctggtt ttgtcaccac 1913701 ataagcgctt aattcggttt gtcctgacgc tgttacatga gcaactactg cggcgtcttt 1913761 tacacccttt atacaccgga tgaccgattc aatttctttc gtttctacac ggtatcctct 1913821 gattttgact tgatcatcga ttcttccgag atattcgagt gtaccgtcgg ccatccatct 1913881 ggcggcgtct cctgttcggt acattcgtgc ttcgggttta aatggattct gcgtgaatgc 1913941 tctctctgtc agttctggaa gattaacgta ccctcttgca agccctgttc ctgctataca 1914001 aagctctccc gcaacaccga ttggctgaag ctgatgattg ctatttaaaa tcagcacttg 1914061 agttccgtca atcggctggc cgatgcttac gtatgcctgc ttttccatat gtctcatgac 1914121 ggtagtcgcc acgctgtttt ctgtcggtcc atattcgttg gcgagttcgg tatgcggaca 1914181 tatagctaag ctgcgggcga tcaattcgcg gtcagccgct tctcccgcca gtgtgacgac 1914241 tctaagcgtc tttacatctt ccggctgcac tacgtccaaa agcgctcgat ataaaacagg 1914301 cacaataatc atatgtgtaa tccgttgacg agacagctga tgcttaatgg ccagaatatc 1914361 cttcgcttcc tcttcatgaa gcaaaacggc ttttgcacct gacaaaagcg gtgtaaacat 1914421 actagttata aagccgtcaa atgagaaaga aaagagctgc agaatggtat ctgtctcgtt 1914481 gaatgcataa gcgtttcgcc gccactgaag agtgttagca atccctttat gctcgaccat 1914541 tacccctttt ggacggcccg tcgttcctga agtataaatg atataagcca aatgatgggc 1914601 agacgacatt tgcggcagcg gcgatttgtc gtcttcctct acgctttcta tcgtcaagat 1914661 ctctccttca aagtcagcaa gtactcccag atccgcttca tttattgtca tcagcagttt 1914721 cgttccgctg tcgctgagga tatagcgttt ccgttctttc gggtattcag gatcaatggg 1914781 aacgtaacag cctccggctt tccacacacc aagtatggat gctatcatac tgaacgaacg 1914841 atgcatcatg atgcctactg gtgtgtccgg cttaacacct cggctgcgca atgcacgtgc 1914901 gattccattg gaccactcgt caagctcctg ataagtgagt gttttgtctc cgctgacaag 1914961 tgcagaagct tttggtgttc gtgcagcttg ctgctcaaac aattgactga ttgtttgaac 1915021 tccgtattga ttcgcttgcc cggtgttaaa ctcattaagc agctggtgcc gctcttcttg 1915081 ggtcaggatg tcgatatggt tgagtgtcac cttcgggttt ttgccgatga tgctaagtac 1915141 atttgttaaa tgcgatgccc agcgttcaat ggtggttttc tcgaacaatg cggttgaata 1915201 ttcaaaaagg aaatgaatgt ttccgtcgcc ctcagatgcc tgtagtgtca aatcgaattt 1915261 agaaacgaga tgagaaactt gtgccggctt catttgcaaa tcatgaagat gcaatggctc 1915321 gtaatcatta ttttgaacaa ctaacatcgc atcaaacact gggttccggc tcatatctcg 1915381 tgtcaattca agcttatcga caagctcttc gaacgggtaa ttctggtgct caaaggcttc 1915441 caatgctgtc tcacgcactt cctgcaaata ctgtacgaat ggcttcccgc cctccgggcg 1915501 cgtccgaagc gccagcgtgt tcacaaacat gccgagtatc ggctcaagat ccttgtgcgg 1915561 ccggccggcg attggcgagc cgacgatgat atcttcctgt ccgcttaagc gtgacaagaa 1915621 cgcggtgtaa gccgcaagga gcaccatgta cagtgtgctt ccgttttctc gtgccagctt 1915681 gtgaaggcct gatgcaacct ctggttccag cgtaaatgag accttgtcac ccgcgaagct 1915741 tcgcaccggc gggcgggcat gatcagcggg gagatccagc acaggcagct cgccctcgag 1915801 ctgcttcagc cagtacgcct cctgcatttt gtacgcgtct cctgttttga atccttcttg 1915861 ccatacggca taatctttat attgaatgcg cagcgccgga agcttccgat tattgtacag 1915921 ctcgccgaat tcttgaatca gaatgttgac ggaaacaccg tctgaaatga tgtgatgcat 1915981 atcaaccagc aataggtgcc gctcatctga tacctttacg atttgggcac ggaacagcgg 1916041 cgcttggctg agatcaaacg gtttgataaa tgcggctgcg gcctcctgtt cggttcgtgc 1916101 gccgagaact gtagtctgta acgtaaacgg cacctcgtca tggatgcgct gcaccggatc 1916161 gcctccttcg tcctgttcga aggaggttcg aagcgactcg tggcgcttga tcagctcttg 1916221 gaaagctctg tccatccttt cagggttgag cttcccttcg agctctaaca cagccggcat 1916281 attgtagcct gtccctccgt cctccagctg ctgaaggaca taaatccgct tttgggcaga 1916341 ggaaaccgga taggtttcct gtttttcagc gggcttaatc gcttcatatg gactgtccgt 1916401 tccttcacgg ataacggtag ccagtccttc taccgtcgga tgggcaaaca catcttttag 1916461 cggcacctgt acatcgaatt ctttggtgat ccgtgagaca agcgccgttg cttttaagga 1916521 atgtcccccg cggtcaaaaa agttgtcgtg aatcccgaca gggccatttt tcagcacgtc 1916581 ctcccacagc tgagaaagct tcatctcagt cacgtttctc ggcgctgtgt aggtctccgc 1916641 atctgccgct ccgccaggag ctggcagggc gtttcggtcg agctttccgc ttggcgtaac 1916701 cggccactgt tccatctcta tcatataggc tgggaccatg tagcccggca acagtctctc 1916761 aagctgcgct cggacttcgt ttctttggag cccttctaca taagcgcata attccggctc 1916821 cccgctgtct gtccgtacgg taacggccgc ctctcttaca ccttctatac ttcttagtgc 1916881 cgcttcaatt tctcccggct caatccggta gccgcggatt ttcacctgat catccgtgcg 1916941 cccgaggaat tcaacattcc cgtcagggag ccagcgcgcc acatccccgg ttttgtacat 1917001 gcgttcaccc gggtaaaacg ggtcttcaag aaaacgctcc tccgttaatg ccggccgatt 1917061 caaataacct ctggcaacac ccgctccggc tatgtacagt tcgccgatac atccaacagg 1917121 cagcatccgc tgattctgat tcaggagata taatctgaca tgatgaacag gttttccaat 1917181 tgggatccgt tcaagttttt catgcggcgg acaatcaaag aatgcagctt ctacggttgc 1917241 ttccgttggc ccataggaat tggttattga aacatttgga agcaactcgt aaaatcggga 1917301 gacaagatgg gtccccagct gttctccccc agaaaacact cgcttgagtc tgtttgtctt 1917361 aatcggtaca gagcgatatt ttatatgttc taaaaatgca tggagcattg aaggcacaaa 1917421 atgcatagct gtgatctttt gttcttctat ggccttcgcg atcacttcag gttctttttc 1917481 gcctccctga ggaagcagat aaacagaagc tccggcataa ggccaccaaa acagctccca 1917541 tattgaagca tcgaatgaat atgatgtttt gtgcataatc atatctgaat gctttagctg 1917601 atagcgggac tgtagggaat tcaaaaaatt caccgctgat cgatgttcaa tttcaacacc 1917661 cttaggcatc ccggtagagc cggatgtata gatgacatag gctaaagatt gcgggagaac 1917721 atccacattc ggattggaca aacgatgtgc cagtccgcta tttgtctgat tgagatagac 1917781 aatctctcct gtaaattccg gaacatgaag gccggcagac tgaagcagga gaatgtttgt 1917841 accgctgtcc tccagcagaa agctgattcg ttcttccgga taatccgggt cgatgggcag 1917901 ataagcgccg ccagctttaa gaatgccata aatgccaagc agcatttcag gtgaacgctt 1917961 tcctataatg gcaacagtcg tttcgggttt taccccccgt ccgatcagct cccaggcgat 1918021 acggttagcc tgttcgttca attctttata ggtcatcact ccatcttcga agataacggc 1918081 cgcctgatca ggcgtttttt ctgcctgctg ttcgagtgca tagtggagcg tttgattcat 1918141 tgaatagccc gtctcctcaa acagatggca tgattcaatg aaatctcgct cttcttcttt 1918201 tgttaagatt ggaatattgt ccaattctgt ttcaggactg gcagctgtat gttccacaag 1918261 cgtggtgaaa aggctggccc acctttggat ggtttctttc tcaaacaaag ctgtactgta 1918321 ttcaaactga cagaaaagct cggaatcatg ctctgtaacg tatagggaaa tatcaaattt 1918381 tgatattggg tgctccaagt cgttccactg aagctgtaca tcattcattt ttagcttttg 1918441 ctgttccata ttctgaagga ctagcgttgt gtcaaacaaa ggattccggc tcatttcccg 1918501 ctgcacaccg agtttgtcca caagctcttc aaacgggtaa tcctgatgct catacgcttc 1918561 tagtgccgtc tgtctgactt ctttcagaaa ttcctcaaat gtcttattac ccgccgggcg 1918621 tgtgcggaga gccaatgtat tgacgaacat cccaagaaca gcttcaaggt cggcatgggg 1918681 ccgtccggcg ataggtgaac caatcacgat atcatcctga ccgcttaacc gagacaaaaa 1918741 ggctgaatac aaagcgagaa gcgtcatata aagcgtgctt ctgtttttat gggcgagccg 1918801 ctttatgcgg gccgtgatct ctttgtccaa ttgaaaggtt acttttccgc ctatgaattg 1918861 ccgttctgcc ggacgtcgtt tatctgttgg aagctccagt ataggaaggt ccccgctaaa 1918921 ctgctgctgc cagtaagtct cctgcttttg gtacgagtct ccctttttaa atttctgctg 1918981 ccatacggcg taatctttat attggatccg caatggctta agctgccggt ttgcataaag 1919041 atcggtaaat tctcggatta ggagctgaac ggatacgcca tctgaaatga tatggtgcat 1919101 atccaccagc aatacatgct tctcgtttga cacttctata aggcctgctc taaataatgg 1919161 cgcctggctg agatcaaagg gacggacaaa tccctcgata gtggtctctt tacttaacgt 1919221 aaacggcact tcggtgtgga tacgctgaac cggctcgtca tcagctccgg atacaaagga 1919281 agttcgaagc ggctcatgcc ggctgatcag ttctttacat acagcagaca gtttggcgac 1919341 atccagtgca ccttccagtt ctaagaccgc aggcatgtta taggcgacac cctcatcaag 1919401 ctgttgaagc acatagattc gtttttgggc cgaagataca ggatatgtat cccttttttc 1919461 tgctggttca attgctgcat acagattttg ttctgcctct cgaataatta aagctaatcc 1919521 ttcaacagtc ggatgagcaa agatgtcctt aagtgaaact tgcacatgga attcctttgc 1919581 gatccgtgac ataagcactg ttgcttttaa cgagtgaccg ccattgtcaa aaaagttgtc 1919641 ttggatgcct atatgcccat tctttagcac atcttcaaat agttgcgaaa gctttgcctc 1919701 taacagattt cgaggggcag tatatgggtt tccgctgatt gaagcatctg gctccggaag 1919761 tgctgcgcga tctacttttc cgtttggggt aagaggtatg ctgtcaaccc atatccattt 1919821 cgccggaatc atgtattctg ggagctcact agccatataa ctgcgtaaat ctattgtgtt 1919881 cagcttttgt acactgcaat agtaagcgca taattcatgt tcaccgtttt gatcttgcca 1919941 gatgagaatg gcagcctcac taatgtccgg atgattcatt agcgtgactt cgatttcttg 1920001 cggctcaatt cgataacctc tgattttcac ttgattgtct gcccgtccga tatattcgat 1920061 gttgccgtct tcaagccgtc tggccaaatc acctgtccgg tacatgatca catcaggctt 1920121 gaatggatcg gatgaaaatt tgtcgcttgt cagtttatcg tgattgacat atcctctggc 1920181 aacacttgcg ccggaaatat agagttcgcc tggtacgccg catggctgaa gctgtttttg 1920241 atgattcaaa atatatagat cagtacagcc tatcggttta ccgattggcg gaagctcagg 1920301 aatagggtct ccaggatgaa tggtatacgt agataccaca tgagtttctg aaggtccgta 1920361 atgattgtgc aggtgtatgc cgcgtttacg caacacatct tggaaaaggt ctgaaatcat 1920421 taattgttcc ccggctgcga tcaggtgttt gacgccatca ggaaacgagt tcgcaagttc 1920481 tcgctcgctg aaaatcattt tgataaaagc agttgggaga aacacaatat tcgtctgatg 1920541 cttgtttata aatgcaaaca gctgaggcac atctcttttt atggcttctg gcacgatgtg 1920601 gagtgtgccg cctttcagaa gcgcagaaaa tatttcttga tagcagacgt cgaaggaagg 1920661 cgtcgcaaat tgcagaacat ctgcttcaaa gtcaatgccg gagtgagtat attcgaactt 1920721 cagcaagtta gccatgtttc gatgctcaaa ttgaacaccc tttggtttac ctgttgtgcc 1920781 tgatgtataa atcatataca gcagatcgtc agcattgttg actgacttta tgttactgcc 1920841 gtctactttg ctttcgatat cttctggatg agtgataatg taattgtctt ctaacgatga 1920901 gggaagatgc gcttgtgaaa caacatgcga acagccgcaa tcatgcagaa tataacggat 1920961 tctgtcagca gggtaatgcg gatcaaccgg aacaatggcg ccgcctgctt tcaagatacc 1921021 aagaacacct gtgataaacg ccgctgagcg ttccatcata atcgcaacgg gttcctgtct 1921081 cacaacgcct ttcattcgta aatgccgtgc caatctgtta gccgctttat tcagttctct 1921141 gtatgttaat gagcaggctt gatcaattac agcatgagca tctggtgtct tttccgcttg 1921201 cttttcaaac atggcatgga tggtttcgta aactggtgtt tgatctgtga tttctccaat 1921261 cagctgccgc ttttcagtat ctgtcgtgat atcgatttct tcaggtggaa gattcggatt 1921321 atttaagatt tgtgatacag cattcagaag atgctctttg acagagagca caaaagaccg 1921381 atcgtgctgc tccgcatcat agttcatttt gatatgaatt tcttcccctg gcgccaccat 1921441 aagataaaag ctgtagttgg tttcatctgc gacagtgaaa ttatgaatct gaaaaagatc 1921501 agaagcatgt tcctgtttgt tcagcatttg aatctcttgc tgcaccggat agttttcaaa 1921561 tacgagaata tgatcaatca gcccttgctt aacagctgag cgggattgaa tctcatataa 1921621 agggtggtag ctgtacgctt cagcggcaag acggtctttt tgcatatctt ttataagttg 1921681 aagaaaaggc gtttttgccc cctgcacccg aaccggcatc gtattaatga aaagacctac 1921741 catatgttca atgccttcga tttctgcggg tcttcctgaa atgacagaac cgaatacggc 1921801 gtcatcgtta ttattatatt tttgcagcag aatgccccaa atggtatgaa aaatcgtact 1921861 gagtgtcact tcttctctag cagcaagctc tgaaagcctg ctgctttctt ccttagagaa 1921921 tgaaaatgta acgtgttcct gcctgctttt tccctttgtt tttttctgct tcgggagcac 1921981 ggtttgctgt tcgtggccgg aaagataatg atcccaataa gaaaccgcct gctctttgtc 1922041 ttgctccatc agccatttga tatactttcc gtatggctgg accggctcca atgttattgg 1922101 ggatgcattt acataagatg cgtaaatatg cagaaactcc tttagcacaa tgctgaggca 1922161 ccaaccgtcc atcatgatat gatgaaaggt ccaaatgcaa gagtactggc tctctcctgt 1922221 ttgaatcaga gcgatgcgca tgagcacatc cttttgcaaa tgaaaccccc ggtcccggtc 1922281 cttttctttc cattgctcga taaactgtga ttgctccgcc tcgtttaaat gagtaatgtc 1922341 ttcttccagt acgatgacat ttcgttctct cagaacaacc tgctgggggg aggaaacatt 1922401 ttggctgata aaaatcgttc tgaaaatatc atgtctttct acaagagcgt tgatgctgtt 1922461 ttgaaaaaac tgcgggttga cttttccttc tattgtaaaa gaagcttgct caacatacgc 1922521 ctgtgaatct ttttgcagga gggaatggaa aagcatccct tcctgcatgt aagacagcgg 1922581 ataaatatcc tgaattgaat tcgcttttgt catgttcatg tctcctgtca cgattttcta 1922641 caattcttcc accaagctgg atatgctgtc caagtcctct gccgttaatg attgactgct 1922701 gaaatcgctc agtgtctttt ctgctttctg ttgaccggcg cagtgtttca taatgtccag 1922761 caaaaagtgt tcaatcctgt taataagctg ttccattgtg tttctgtgaa agcgggctgg 1922821 cggataacta agattgaaat ggagcttttt gtctgctgcc attgcactca tctcgatgat 1922881 ttgctcgcgc ttccatgtat gagtgatatc ctttccgcta ccaaggcttg atgggcggaa 1922941 ggtgtcctgt ctttcgatgt cgttgaactg gcccaaatag ttaaagctga tttcaggtgt 1923001 ttttgaaaac gtaatgcttt tattttcagg gtgtgtaagg tatttcagca taccgtaacc 1923061 tacccctttg tttggtatcc ggcccagtgt atctttaacg gtttttactg aggttccgag 1923121 ctcatcccta tgattttcaa agcttatgag ggccgggtac atggatgtaa accagccgac 1923181 cgtcctgctt atatctaact ctggcagaat gtgttctctc ccgtgtcctt ccatagcgat 1923241 acggagcttg cttcctcctg tccattcaca aatcgccaag gatgctgcgg ttaacagaat 1923301 atcttgtgta tctgtgccat aggcgtgatt gacgttttgc agcaagacgg cggtgtctgc 1923361 ttcagtcagt gaaaagctta atgagtccct tttgctgaag tcgatgttca catgatgcgg 1923421 tatttcatag ggcagttctg cggcttgctg ttcttctaca cttcgccaat acgcctcttc 1923481 gcgaatcagc ttactgcttt gggcatattc ctgtatgcgt cttgcgtatt cctggtagga 1923541 atccgtttta ggcggaagct ggatcgtctg gcctgcagca gcttgttgat atccggctga 1923601 caaatcctcc agcaaaatcc gccatgagac accatcaacg acaaggtgat ggatcgcaag 1923661 gaacaagtaa tctccggtca gtgttttaaa caaagcggcg tgcaacaatg gtccttcctg 1923721 caaattgatg ctttgctgaa gatcggcaac ttcttgtttg attttcgtct cccagccgct 1923781 ttctgactgt gaaagatcag agattcttaa gctgtatagc tgtgactcat gaatgccttg 1923841 gttgatttga atccatcgcc tgtcatcgtt gcgataaacc atccgaagcg catcatgatg 1923901 ctccgccagt tttttcaagg ctggtctaag ggcgttttca gacaaacgtc cagaatggaa 1923961 tagcatgaca gactgattga aatggtgtct ttcttcaata tcttgtgaaa aaaaccattg 1924021 ctgaacaggc gtccaaggaa cgtcaccctg aatgggtcct tgctctatga ttctctctga 1924081 cttacggata aatggtgata agtcctttat ctttggatga cggaataaat cacttacctg 1924141 caagcttagt ccatagcgcc caaggcgtgc agaaacttga agggctttga ttgaatctcc 1924201 gcccaattca aaaaacgaat cctctattcc gatcctctgg atgcctagaa cctcctgcca 1924261 gatcaatgcc agctgctctt caagttcgtt gcgtggcggg atgtatgttt gtttagatgc 1924321 gacatctggt tcaggcagtg ctttccggtt caatttgccg tttgatgtga gcggaagagt 1924381 ctccatttca atgatatacg ccgggatcat atagtttggc agcgaacgcg cgagaagaga 1924441 acgcacttgt tcagcattcg tgcctgcttt tacgctgata tagccaaaca gctctttgct 1924501 cccggtctgg gctgtacgtg ctaacactgc ggcttctttg accccgtcta tttgacgaag 1924561 tgctgtttcg atttcaccca gctccacccg atagcctctg acttttactt gatcatcaat 1924621 acggccaacg tactcaattg tgccatcgga aagccagcgc gccagatcac ctgtgcgata 1924681 cagtcgatcg ccaggtgcaa atggatgtgg gacaaatttc tctttcgtta aatcaggacg 1924741 gcccaaatat cctctggcga cgccatctcc gccgacacaa agttcaccga cagctccgac 1924801 cggctgcagc actccccatt gatttaagat aaaagcggtg gaattaccaa ccggccgccc 1924861 gatcggaatg gaaagttcat atgttttttg aatgtgaagg catgtcgaaa aagttgtatt 1924921 ttcggtaggg ccatatccat tccatataga tacttcaggg cagacatttc tgattcgatt 1924981 gacgtggctc ggcgacaaag cttctccgcc aataatcaaa tgtttcagct gtgaaaatgt 1925041 ttgttcattt tgctctgtca aatgattgaa tagagaagat gtcagccaaa tcgttgtgat 1925101 tccttgatgt tctatgtacc tcttaagctg atgggaatcg agaaatgttt gttgatcgga 1925161 cagatgcaaa gcggcaccat ttagcagcgg tccgaaaatt tcaaatgacc caacgtcgaa 1925221 accgattgat gatgtcatca gaaggcggtc ttcaggtgta aatgtaatat aattgctgtt 1925281 tttaacaaga cgaattacac ttcgctgctc aatcatgaca ccctttggtt taccggttga 1925341 tccagaggta taaatgatat atgcaagtga atggggccct gctgaagatt caacgttctt 1925401 cgcctctcct tgcttttgaa tatcttcgat tatgatttgt tcacattcaa tgcctaatag 1925461 ccgtttttct gttttttcag attgaaggag taatgctgcc ctgctgtcag acagcatata 1925521 agctatgcgt tcaacaggca gattagaatc gataggcaga taggctcccc cggcttttag 1925581 aatgcccagc attcctgcaa tgagttctgg tgttctgcct gtcaacaagg ctacaacact 1925641 atcaggccct acgcccttta tctgtagaac tgaggcaatt tgatttgccc agctgttcag 1925701 gtcctcgtaa gtgaatactt gggtgtcgct gacaattgct acagcattag gtgtttgttc 1925761 tgcctgcatt tcaaagagtc tgctgatggt ttcatttctt ggataatcta tttttgtacg 1925821 attgagctcg tggataaggt aatgggcctc atcctcattc aggatattta ttgttccgag 1925881 agcggctttg ttgtctttga tgatggagag taacatattg ttgaagtatt gaagccactt 1925941 ttctatcgtt tttttcttat ataagtcagt actaaactcc atttggaacg tcagcaaacc 1926001 gcggggctgt tcctgggcat atagggttaa atcaaatttg gacgtttgat gcccattgtt 1926061 tgctgcaggt ttgagacaaa gttcatccag ctccaacgat tcctgatcca tattttgaag 1926121 aacaaacatt acgtcaaaca gcggatttct gctcatatct cgtgtcaatt caagcttatc 1926181 aacaagctct tcgaacgggt aatcttggtg ctcaaaggct tccattgctg tctcgcgcac 1926241 ttcctgcaag tactgtacaa acggcttccc gccctccggg cgcgtccgaa gcgccagcgt 1926301 gttcacaaac atgccgagta tcggctcaag atccttgtgc ggccggccgg caattggcga 1926361 gccgacgatg atatcttcct gtccgcttaa gcgtgacaag aacgcggtgt aagctgcaag 1926421 gagcaccatg tacagtgtgc ttccgttttc tcgtgccagc ttgtaaaggc ctgatgtaac 1926481 ctcttgatcc agcgtaaatg agaccttgtc acccgcgaag cttcgcatcg gcgggcgggc 1926541 atgatcagcc ggaagatcca gcacaggcag ctcgccctcg agctgcttca gccagtacgc 1926601 cccctgcgtt ttgtacgcgt ctcctgtttt gaatccttct tgccatacgg cataatcttt 1926661 atattgaatg cgcagtgccg gaagcttccg attattgtac agttcgccga attcccgaat 1926721 cagaatgttg acggaaacac cgtctgaaat gatgtgatgc atatcaacca gcaacaggtg 1926781 ccgctcatct gataccttta cgatttgggc acggaacagc ggcgcttggc tgagatcaaa 1926841 cggtttgata aatgcggctg cggcctcctc ttcggttcgt gcgccgagaa ctgtagtctg 1926901 taacgtaaac ggcacctcgt catggatgcg ctgcaccggg tcgcctcctg cgtcctgttc 1926961 gaaggcggtc cgaagcgact cgtggcgctt gatcagctct ttgaaagctc tgtccatcct 1927021 ttcaaggttg agcttccctt cgagctctaa cacagccggc atattgtagc ctgtccctcc 1927081 gtcctccagc tgctgaagga cataaatccg cttttgggca gaggaaaccg gataggtttc 1927141 ctgtttttca gcgggcttaa tcgcttcata tggactgtcc gttccttcac ggataacggt 1927201 agccagtcct tctaccgtcg gatgggcaaa cacatctttt agcggcacct gtacatcgaa 1927261 ttctttggcg atccgtgaga caagcgccgt tgcttttaag gaatgtcccc cgcggtcaaa 1927321 aaagttgtcg tgaatcccga cagggccatt tttcagcacg tcctcccaca gctgagaaag 1927381 cttcatctca gtcacgtttc tcggcgccgt gtaggtctcc gcatctgccg ctccgccagg 1927441 agctggcagg gcgtttcggt cgagctttcc gcttggtgta accggccact gttccatttc 1927501 tatcatatag gctgggacca tgtagcccgg caacagtctc tgaagctgtg cacgcacttc 1927561 gtttctttgg agcccttcta cataagcgca taattccggc tcgccgctgt ctgtccgtac 1927621 ggtaacggcc gcctccctta cgccttctat gcttcttagt gccgcttcaa tctctcccgg 1927681 ctcaatccgg tagccgcgga ttttcacctg atcatccgtg cgcccgagga attcaacatt 1927741 cccgtcaggg agccagcgcg ccacatcccc ggttttgtac atgcgttccc ccaggtaaaa 1927801 cgggtcttca agaaaacgct cctccgttaa tgccggccga ttcaaataac ctctggcaac 1927861 acccgctccg gcaatgtata gttcgccggc gacaccggaa ggctgtacgg ctaaatgcgg 1927921 atctaaaaca tacaaacgcg caccaggtac gggcttccca atcggaatcc gcaaacggtc 1927981 tctgtcccgt tctggatcta acacgtaaaa tgccgcgtct accgtggctt ctgtcggccc 1928041 gtagccatgg attaatgata cctgcggcaa tacagaagca aaacgggctg ccgtacgcgg 1928101 cgcaagcggt tcacctccgg cgaatacacg ctttaggctt gtcctgtcac tcagcctttc 1928161 gatttccgct tgatcgagaa agctgttcag catagccgga ataaaatgag ccgttgtcac 1928221 gttttcctga tgaatggctt gtacgatcaa tgcggagtct ttttcccagc cgggcggaag 1928281 cagatacgcc gaagcaccgg aaagagccca ccaaaacagc tgccacacag acgcatcaaa 1928341 ggaaaaagag gttttcacca tgacaatgtc atcttccgaa agccgaaact ggtgctgcat 1928401 gccggtcaga aaggaaacag cctggcggtg ctcaacggcc actcctttcg gctgcccggt 1928461 agagcccgat gtatagatga cataggcgag agatccgtcg ctaacagaag cagacacatg 1928521 acgttttact tcttcacact caagagatgt catgtccact tcaagcgttt cgccagaaaa 1928581 gtttggtgcg gagcatcccg gctgtgtcag caagagcgat gccccgctgt ctttcagcat 1928641 gtagctcagc cgctcctttg gatacgcagg atcaagcggc aaatacgccc ctccggcctt 1928701 caatacagca aggacagcga tcagcatgtc aggtgagcgt tcagacagga caccgacgat 1928761 actttcgttt gtgacgccgc gtgccgcaag gtgcgcagcc agccggctgg cgtacatatc 1928821 aagctcagcg tatgtcagcg aaccgcctga aaagcgaatg gccagccgct ccggtgtgac 1928881 tgccgcctgt cgttcaaaca gcccatgcag ggttggggct tcaggtgaaa cagatactgt 1928941 cctgttattt tgagaaacga ttttccgtgt tttgtcctca tctagcaacg tcatctttga 1929001 cacaggaaga gatggatcag agatgacgtc agagaccatg tgcagcaaat aatcttttat 1929061 ttcggacatc atgcttggtt gataagcgct ggtctgaaaa tgaatccgaa cgtacaaggt 1929121 acggcctggg atcactttga cactgcaact ataattggtc acctcttcca tctcaaaatc 1929181 tttgacggag aaatcaaatg accccgcttg attcagctct tcgatctctt gctgggtagg 1929241 tgtattttca aagacgataa tatgatcgat caactcttgc tttagagcac tctgcgcctg 1929301 aatatcatac aagggaaagt aactataggc ttctgcctca ttcatgtcct tttgcattct 1929361 cctgactagg tcagaaaaag acagagaatc actttgggct cgaataggaa tggtattgat 1929421 aaaaagcccg accatgtttt ccacatcttt tagctcagaa ggtctgcctg atataactga 1929481 accgaacaca gcatcgctgc tgcgattgac cttttgaagc ataatccccc ataaagcttg 1929541 gaaaacagtg tttagtgtcg caccagaagc tgctgcgatt ttctgtaatt cggcggtttc 1929601 tttttcggga atggcaaacg tgatctgctg tagtgtccca ttcggaattt gatctgttct 1929661 tttcggcagg ggtgtagatt tttcgaaatg ctgaagcctc tttttccagt actcagctgc 1929721 ttcttcacga tcttgctgca tcagccattt aatatacgtc ccgtacggct gtacgggagg 1929781 caaatcagga agctggcctt tacccagcgc ttgataaata tggagaaagt ctttaatgac 1929841 gatgcctaaa caccagccat ccattaaaat atgatggtgg ctccagatac agacataatg 1929901 atcaggcgcc cattttaaaa tagatattct catcagtaca tccgtttgga gatcaaagcc 1929961 tttggatttg tcctgctctt tgaatgcctc ggtacaatgt tctttatccc tttcattgag 1930021 atgggaaata tcttcaatat gaatagggca atgacgttgc ttgagcacga cttgacgagg 1930081 tttggctaca tttttataga tgaatgctgt tcgaaagata tcgtacctgt caaaaacagc 1930141 atccatactt ttttggaaac gctccaagtc aagctgtcca tggatcgtaa aagaagcctg 1930201 ttcaaaataa gctctcgact gttcatcata cagtgagtga aaaagcatcc cttcctgcat 1930261 aaatgacaaa gggtatatat cctgtatttc aggttgctgc ggcatcagtg aatctcctct 1930321 cctatagttt gttgacggct cccatgatct cactcaattc atcaagcgtt aagtcttcat 1930381 cagtgaaatc agatgcgctc cactcttggt tttctttgcc ggtacaatgc tcaatgatgt 1930441 tttccagagt ctgtttaaaa tgcctggaaa atgtttggat tgttttttcc tcaaattgaa 1930501 acctgttata gatgatgtgc atgttcaggc accccgaaga aacggcgccg ctgatatcca 1930561 gtgcataagg acgctcccag ttcgggctga tctcatttcc tggcttgatg tcagacacct 1930621 caaaggcatt tgattgaata tcctgatcaa actggcctaa ataattaaag ctgatttctg 1930681 ggctgttttt ctgagagccc catcttttgc tgatatattt cagcacgccg tagcccgcgc 1930741 ctttatgcgg tatacggtgc agcatatctt ttgtctgttt aataaggtgg cccagccgct 1930801 cttctttgtc cttatgatcg gaatctctca tatcaagcca cacaggataa atggaggtga 1930861 accagccaac agttctgcta atatcgatgt cctcaagata tgattccctt ccatggccct 1930921 ccatgctgat tttaaattgg ttatttcccg tccatttctg caaagcaaga cctaaagctg 1930981 tcagaaggat atcattcatc tccgtgctgt aagctttatg tgcagccgtt aatagtaatt 1931041 ctgtgtgatg gcgagatagc tcaaaatcaa tcacttctgt atctttgaat gtgttagatg 1931101 ctgcgtcatt gtcttttgga ataggctgga tgtgacggtt ctcgcactca tcccagtacg 1931161 ctgcttcgcg ctgcacctgg cggcttatag agtagtcagc tattctttgt gaatacgtta 1931221 aatatgaatc tgttttttgc ggcagtttaa tagattctcc tgagactgcc tgtttgtaag 1931281 ctgttgaaaa atcctcaaac aaaatgcgcc aagaaaccgc atcaacaact aagtgatgaa 1931341 tcgttagaaa taaatggtca ccattctcgg ttctaaacaa tccagcgtga agtaaggggc 1931401 cggtttccaa acgaatatgt tcttgcatcc ggctggctgc ttcctcaatc gtgttccggg 1931461 cttctgttag gctatccttt acatcaaaca gttcaagtgc atatagctcc tcatctgaaa 1931521 gatctatccc tctgtttatc tgcacttgcc tgccatcttc atgccggcat acgattctca 1931581 gtgcatcatg atgagtcaca aggcttttta gtacttttct aagcgcagcc tcatcaaatc 1931641 gttcagcccg gtagatcata acggattggt taaaatgatg gctttccaga gattgcgaga 1931701 aaaaccactg ctggataggt gtccaagtaa tctcgccttc gaccgggcct tggtcaatgg 1931761 cgcgtacgtc ttttcgaacc cgggcggaca gttcaccaag agtctgatgt tcaaacatct 1931821 cacgtactgt cgtttcaaat ccgcgctgct tcagtctggc acaaacctgc agcgctttaa 1931881 tagagtctcc gccaagctta aagaaattgg cgcttacacc cagctcatct acattaagaa 1931941 gctcttccca aatttcagcc atcaccgttt caatctcatt tctaggactg atatcatcag 1932001 ctgtataagc ttgtttttca ggctctggca gggctttctg atcgagcttt ccattaacag 1932061 tcaccgggat gctgtcaatt tgtatcatac gggcaggcag cataaagtca ggcaaggcgt 1932121 tttttaggta agttcggatg tctgatatat tcgcagcctg ttgatctttt atcaccatat 1932181 atgcatatat agctgtttgc ccttgctcgt ctgctctggt aatgacagcc gcctctttaa 1932241 tcattggata ctgaagaagt gccgcttgga tttcgcctaa ctcaatacgg tgccctctga 1932301 ctttcacctg ctcatcaatg cggcctaagt attccagctc gccatttgac aggcgcttag 1932361 caagatctcc tgttcggtat aatctgtctc ccggaagata aggattggat acaaaacggt 1932421 cagcggtcag ctcatctctg ttgagatatc cccgtgccac accttcgccg cctatataca 1932481 gctcccctgg aactccggtc ggctgcaggt tcatatgggc atccatcaca tgagcctgca 1932541 gagtagaaag aggccggccg atattgcttt tattttttgc aatgtctgct gcggacaatt 1932601 ttttgaatgt tacatggacc gttgtttctg taataccgta catattaatc aaatcagtat 1932661 gaggatattt ttcattccag ctttgaagca atccgggctg taaggcttcg ccgccaaaaa 1932721 tcacatagcg gatgtttaaa tgatctgtat gattttggtc ttcaagcatc aagccgtaaa 1932781 aagcagtcgg ggtctgattg agtacagtga cgcgctcttt ttttaacaat aatcggaatg 1932841 cttgggggtc acgggctgtt tctttagaga ccacgactaa tgtacttccg ttcaataacg 1932901 caccgaacat ctcccataca gagaaatcaa agcaataaga atgaaataac gtccagacgt 1932961 cttcatggtt aaattcaaaa ggcaggtttt gatgcttcaa gagactgatc acattgcggt 1933021 gctcgacaat gactcccttt ggctgaccag tcgttccaga tgtgtatatc acgtatgcgg 1933081 gctgatccgt tactatttct tcaatgttta catcagccgg aattgagttg ttttcacatt 1933141 catcgatata caaaatatgc ccggtgtagt ctgcaggttt gtttagaccg cgctctgtca 1933201 gcagcagttt tgctccgctg tcattgagca taaagctaat acgctccttg ggatattcag 1933261 gatcaatcgg caaataggcc ccgccagctt ttaaaatcga taaaacgcca atgatcatat 1933321 caggtgaccg atcgagcatc agaccgacga tatcgccagt tctgacccct tgtttgatca 1933381 gcatagcagc tgcccgctcg gctttttcat tcaggtctcg atacgtaagc tgagaatggc 1933441 cgcacaccac tgcgatatgc tccggatact gagctacttg cttttcaaat aagcttacta 1933501 tgttttcatt tctcggataa gctgcatact gccccatttt ttcaaggagt aacctacgct 1933561 ctgcagcagg aagcaattgc atgttcgaaa ttctcatctc agtatccgcc gttacccctt 1933621 ttaccaattc aataaaatag gatgcccact gcgtaatggt ttcttcttca aaaagagcag 1933681 tgctgtattc aaaacggcag cgtattccac tcagatgctc ctcagcatgt aatgttaaat 1933741 cgaatttaga tatatcatgt ttaggagtga cagacgaaat cgacagacca ggcacttcga 1933801 accggaaatc ttcactgctt tgaagcacaa gcatcgcatc gaacagcggg ttgcgattta 1933861 cctctcgatt tgtatcgagc ttatctgcca gctcctcaaa aggataatcc tgatgctcgt 1933921 aagcggtcag agccaggtgg cgaatgtcat gcaaatagga gctgaacgtt ttgtggccct 1933981 cgggcttgct gcgcatcgcc aatgtattga cgaacattcc gatgacgcgc tccagatcag 1934041 cgtgcggtct tccggcagca ggcgaaccga caacaatatc ctcttgcccg cttagcttag 1934101 ataacaaaat agaatagaca gccagaagaa tcatatacaa tgttgttccc gtttcagcca 1934161 ttaaacggtg cagttcatca gccatgtctt tatcaatgtt gacttcaatt gttccacccc 1934221 tgaaatcagg gagacgcggc cttgttttat caagcggtaa ttctagtgta ggaagactcc 1934281 cgccaagctg accgagccag taggcctcct gttttttgta tagctctttc gggtgcttct 1934341 cttgctgcca aacagcaaaa tccttataat gcaggtttaa agctggcaac tcttttccgc 1934401 aatataagtc agtaaattct tggacaagag tgctcatcga gacaccgtcg gcaataatat 1934461 ggtgcatatc gagcagcaaa aagccgcgat tattgcccat tgtaatgaca catgctctaa 1934521 aaagcggacc ggatgataga taaaacggtt tgataaaggt ctcgattgca gactcaagca 1934581 tttgttctga ttccatttca agctctttta gatcaaaagc catctctgga taaatgatct 1934641 gcacaggctc gtctctgtca agcacaaaaa cagtccgtaa tgcttcatgc cgattcacaa 1934701 gttctgtgag aacgcttctc aaccgctggc gattcagatt tccgcgtaat tcaagtacag 1934761 ctggcatgtt gtagcctgtg ctgtcatctg ccagctgatg aagagcatat aatcgttttt 1934821 gcgagaaaga cagcggatag acatctcttt gatccgcagg ttcaatctgt gtaaaagcgt 1934881 gttcttttaa gctcatcaat ttgaccgcca tgctttcaac cgtcggataa gaaaacacct 1934941 cactgagcgg cagctcgaca ttaagctttt tatgtattct tgataccagt gcggccgctt 1935001 ttaaggactg tccgcctaac tgaaagaaat catcacgaat gccgatgtgc tgtttattca 1935061 gcacatcttc ccaaatatgt gcgagatcag cttcgattaa ggttcggggc gccatatatg 1935121 tgacactcgt attgttttct ggttcaggaa gcgcaaacct gtcaagcttg ccgctggatg 1935181 ttaatggcat ctggctgatg ttgataatac ttgctgggat catataggac ggcaatgtcc 1935241 cggcaagatg ctgatacaaa tctgggaggc tgtttccctt ttccggaacg atataagcaa 1935301 cgagctcctt ttcctcagca gaaacatcac gggccagtac cgctgcttct tttacccccg 1935361 gtgcttgtcg aagaactgtt tcaatctctc tcagttcaat acgataaccc ctaattttca 1935421 cttgatcatc aaaacgtcca atatattcaa tcgttccatc aggcaaaaag cggcctgcat 1935481 cacctgttcg gtataaacgc tccccttcaa ggaatggatg atcggagaat gctttctgtg 1935541 tcagctcttg ctgtttgtag tatcctctcg caagacccgc gccggaaata cacagttcac 1935601 ccgccgcgcc gatcggctgc atttgatttc cgtgcaaaac aaatactttt gtgtttctga 1935661 tcgggtgtcc gatcgtgatc ctctcttttt tattcagatg ccgcaatatt gttgttgcca 1935721 cactgttttc tgtgggcccg tattcatttg ccagttcagc agaaggacaa attatttgat 1935781 tcaactcaag cagatcaggc gtgaccgctt cacccgcaaa tgtcacaata cgaagacttt 1935841 ttgcatcgtc agcagtcatc acttccaata acaccctgta cagggaagga acaatgatca 1935901 tgtggctgac cttataacgg gctatttttc gcttaagggc cagcacatcc ttcgcttcgt 1935961 catctgttgt cagcagtacg cacgcaccag ataaaagcgg ggtaaataag ctcgttacac 1936021 agccgtcaaa cacgtacgaa aacaaatgga gggatatatc ctgttcggtc atgctatact 1936081 cttcccgtct ccattgcaat gtattggcaa taccgtgatg atcaactaaa acccctttag 1936141 ggcgccccgt cgttcccgac gtatagatca agtaggctag atcacctggc ggcatatttg 1936201 gcgcttctgt ttggtaactt tctgtatgtt ctatcgttat cgtatttcct tcataggacg 1936261 gagggatcaa ggaaataagg tcttcttcta tcagcaattg agccgcttga ctgtccttca 1936321 gaagaaaaga aagacgttct gctggaaaat gtggatcaag cggcatataa gcgccgcctg 1936381 ctttccaaat cccaagcaga gctgcaggca tttccattga ccggcccatc attacagcaa 1936441 cgatatcccc agatccaacg cctttttcta tcagggcgtg cgcaatctga ttggctctta 1936501 cttgtaactg gcgataggtc cagcactcgt ttcccatttt caatgcagca gcttcaggtg 1936561 ttttgtgagc ttgttcctca aacaattggg gtatcgtttt gttcacataa ggacgctcag 1936621 tttcgttaaa caattggata acctgttgct cctccggcgg cacgatattg atgtcactga 1936681 cggcaacatc gggatttgtc aaaatgcaat ccagtgcttg ctttagatgc ccctgaatcc 1936741 tcagcatctc ctcccgctcg taaacgtctg cgttgtagct gaatttgata taaaatgatt 1936801 ctcccggaac gataacgata ttaaagtcgt aattggtttg ttccgacatt gaaatgtcac 1936861 tcagcttcag agcgccttcg tcattttcac tctccacgct taatgcctga tgaagctgta 1936921 cagggtaatt ttcaaaaaca aaaatatgat cgatcaaccc ttgcttcaat ggactatggt 1936981 tttgaatctc ataaagcgga taatacccat gctgttcaga tgataaaata tcctcctgca 1937041 cggctttgac cagcgaagaa aatgttatgc cttccgcaga tcggattcgc actggaacag 1937101 tattgataaa caaaccgacc attgattcaa tcccgtcaat cgctgacggg cgtcccgaaa 1937161 tgacggagcc aaaaacggca tcatctgcag cattatatcg atggagcagc acgccccaaa 1937221 tactcataaa cagcgtgttt aatgtcactc cccagttttg ggcagcctct gtcagtttct 1937281 caaccatatc cggcgctaat gaaaagctga cctggtcggc tttataattc ccgtctgccg 1937341 tgcggcgctt tattcgggga atagaagcag tattgccgta ctccttcaaa tattcgctcc 1937401 agtaggcagc agtctcttct tgatcttgtt ctccgagcca ttcaatataa cggctgtacg 1937461 gcaccgtgct gccaagctgt acaggtgagt tatttttgag cgaatcatac atgctgaaaa 1937521 actctttaag aataatgccg agacaccacc catccatgat gatatggtga tgtgtccaga 1937581 cacatgtata ttggctgtct cctctatcaa aaagggcaag acgcattaaa ggatcttttt 1937641 gcaaatcaaa tcctttttcc cgatccttag tcataaaagc atcaatcagc gtctgctgtt 1937701 cttgatcagc caggcgagaa atatcttctc tatatactgt caattcacgg tttgatagaa 1937761 ctacctgctg cggacctgta agatctggta cttctttaat gaaaatcgtt ctgaaaatat 1937821 catatctaga aacaagaagg tttaagctct tttgaaacga gtcgacgcat agattccctg 1937881 tgatcgtaaa cgaggtctgt tcgatatatg ctttcgagct gaaatccatt agtgaatgaa 1937941 acagcattcc ttcctgcatg tgcgataacg gataaatatc ttgaatttgt gccgattgtg 1938001 ccatcaattc cacacacctt ttcaaaagtt aaagatcttt cacgagatct tcgatgctag 1938061 ataatgcaga caacgttaat tctttattgc tgaaatcgct caatgttttt tcgcgtgctt 1938121 ttttctgcga acaatgctca atcgtctcga taagatgcct gtgaaaacga tccataaagc 1938181 actcaattga gtgtttgctg aacacttggg tgtataccgc ttttacgtga agccgtccgt 1938241 ccgtaatgag agcattgatg tccagctcat actctcgttc tctctcaccc gctatttcgt 1938301 aacggggctg gtaatatgat aattgaaacg tttcaacttc cttctcttcg ctaaattgac 1938361 cgagataatt aaagctgacc tcaggctctt tatgccgcag ttctcctatg tgtgttaaca 1938421 atccgtatcc agttcctttg ttcggtactc ttctcagcat atcttttgtc gtcttaattc 1938481 ggtatgcgag ctgatcctcg aaaggctcgg gaatacccat gtctagcaga ataggataaa 1938541 tggaggtaaa ccatccaact gtccttgaaa tatcaatgtt tggcacatgc ccttctctac 1938601 cgtgtccctc agtgctgatc acgatttggt catgcccagt ccattcagaa agcgccattc 1938661 ctaaagccgt aagcaaaagt tcgttggcat cagtaccata ggcttgctgg gtttcaaaca 1938721 gcaatttttc agtccagtcc ccggatagta caaacgctgc tgcgtcgctg ttcatttgga 1938781 gtttgtctgg cacattttct atgtccttag gaagaaaagc agtgtgagcg tctaaaatcg 1938841 tttgccaata cgttttctct gaaagcaatt gtttactttc agctatttgg gtaagaccat 1938901 cggcgtagga taaataagaa tccgtttttg gcggtaattg gatttctttc ttttctaaag 1938961 cctgttgata tgctgcagct aaatcctcaa gcagaattct ccaagaaacg ccatctatca 1939021 caagatgatg aagtgcaatc agcaaatgat ccccttctgc cgttttaaac aaacctgctt 1939081 gcagtaaggg ccctttttct acattcattt tgctttgaat gacggtttcc tcagcggcaa 1939141 gtttttcatc aagatgagcc ctttccagcg atgcttttgt ccaatctgaa atataaaggc 1939201 caaacagttc atgatccttg tgattgattc cgcgattaaa ctgaatgaca tggccgtttt 1939261 ggtcacgttg gaaaatcatg cgaatggcat catgatgctc ggttatttta cgcagcgcta 1939321 gatgaagcgc gttagcattg aatccttttt cactgaaaag catgacggac tggttgtaat 1939381 gatagtgaaa agcatgtacc tgtccgaaaa atcttcgctg aatcggggtg agttcagctt 1939441 caccttccgc aggtccctgg tccgcttgag atgccaatgg tgtgatatgt ccgcatagtt 1939501 cctgaatcgt tgaataacgg aataagtcgc gtattgtcat gctccagcct tcagctgcca 1939561 gacgtgctgc cacttgtaat gctttaattg agtctccgcc aagctcaaaa aaggaatcgt 1939621 gaatgccgac tcgtgacatg ctcagtacat cttcccatat atacgccatc gttttttgta 1939681 agtcgttaac tggtgcggta tatggacgcg ataacacatt atttggagcc ggcaaggcat 1939741 ttctgtccag ctttccgttt agggtcagcg gcatgtttac taaaggaatc agatatgcag 1939801 gaatcatata cgctggcagt tcctttgtta aagcagcacg gagagcattc gtattgacgt 1939861 ctgaaggcac aatatatgct gccaaaccag cctgtccatt tttatcatgc tgaacggcaa 1939921 cagcagcttc tctgacaagc cccgtttgaa gcagaacact ttcaatttct tctgtttcaa 1939981 ttctgtatcc atttatcttt acttgataat ccattcggcc aagaagccgg atcgttccgt 1940041 ttggaagcca gcatgctcga tcaccggttc tgtacagcct ttctccagag acaaatggat 1940101 tttctgtaaa tttcatttgc gttaagtcag gtttatgatg atagcctttc gcaacacctg 1940161 ccccgccgat gcacagctcg ccggcaacac cgatcggctg aatttgatca gtctggctga 1940221 gtacgtacat gtgtacattc ggcagcgggc tgccgattgg tacgttatct cccgtacact 1940281 ctccacccat actggtttca tagaaactcg aatcaatggt tgcctctgtg acaccatagc 1940341 tattaatgat gcgcatgctt tggccaaagc gatctgtcaa tgttttgaaa tcttgagctt 1940401 tcaccatgtc ggaaccaaga atcagtatgt ctaagtcagg aagcttgaac tggttacggt 1940461 atacatactc catcaccggg ataatgagag ccggtgtcga ctccatcacc gtgattctct 1940521 gagatttaat gattttatat atttcagcag gttccagccg tgtttcatct gggcaaacga 1940581 ttagagtccc gccgttggtc aatgttctcg ccaaatctcc tgagaagaca tcgaatgaaa 1940641 agctcgcgat ttgaagcagt ctgacaggct tccgatccag ttcataaatt tgacgccaag 1940701 caagagcagc atgagtaaag ttctgatagg tgacaataac acctttaggc gcacccgtcg 1940761 ttcctgacgt ataaatgata tataccggct cttcaggagc aggagataag ttaaggttgc 1940821 agttactttc ttcaaaagag ccctcatcgt caaggaagat gtgagacatc tcagattcag 1940881 gcgagttcga aatcaaatgc ttcaactctc tctgtaaaag aagaatatct gccccgctat 1940941 cacgaagaat gtattcaata cgagcttttg gataatgtgc atcgattggg atatacactc 1941001 cgccagcttt catcactgcc agaactccaa caattgcatc gatggaccgc ttggctaaaa 1941061 cagccacagt tggcttcggt ccttttctgt tttgcaatgt tcgtgccaga cgattggctc 1941121 tttcatttag aaggcgatag ctaatctctg tttcgttatc aataacagct atatgttctg 1941181 gattttcttc agctttcgct tcaaatatgc gatgaaaagg aatatctttt tgagcaaatt 1941241 caacttgagt tttgttaaat tcaaagacta ttttttgttt ttctttatca ctaagtatgt 1941301 ttatttgtgc aaggcttgtt tcaggagttg aaagtgcctc atgcagaaat tcgataaaat 1941361 gatcagccca gcgttcaatc gtagctttca ggaatacttc tgtactaaat tccatttcgc 1941421 agcaaataga tccacttatt tccgtagcta ttaatgtgat atcaaataag gaaatgtgat 1941481 gtgcgaaatt ggcaggccgg acttttattt ctctcagatc tatgtcttgt ttttccacat 1941541 tttgaaggat aaacatcgca tcaaacactg ggttccggct catatctcgt gtcaattcaa 1941601 gcttatcgac aagctcttcg aacgggtaat cctggtgctc aaaggcttcc aatgctgtct 1941661 cacgcacttc ctgcaaatac tgtacgaatg gcttcccgcc ctccgggcgc gtccgaagcg 1941721 ccagcgtgtt cacaaacatg ccgagtatcg gctcaagatc cttgtgcggc cggccggcaa 1941781 ttggcgagcc gacgatgata tcttcctgtc cgcttaagcg tgacaagaac gcggtgtaag 1941841 ccgcaagaag caccatgtac agtgtgcttc cgttttcacg tgccagcttg tgaaggcctg 1941901 atgcaacctc ttgatccagc gtaaatgaga ccttgtcacc cgcgaagctt cgcaccggcg 1941961 ggcgggcatg atcagccgga agatccagca caggcagctc gccctcgagc tgcttcagcc 1942021 agtacgcctc ttgcgttttg tacgcgtctc ctgttttgaa tccttctcgc catacggcat 1942081 aatctttata ttgaatgcgc agtgccggaa gattccgatt attgtacagc tcgccgaatt 1942141 cccgaatcag aatgttgacg gaaacaccgt ctgaaatgat gtgatgcata tcaaccagca 1942201 acaggtgccg ctcatctgat atctttacga tttgggcacg gaacagcggc gcttggctga 1942261 gatcaaacgg tttgataaat gcggctgcgg cctcctgttc ggttcgttcg ccgagaactg 1942321 tagtctgtaa cgtaaacggc acctcgtcat ggatgcgctg caccggatcg cctcctgcgt 1942381 cctgttcgaa ggaggtccga agcgactcgt ggcgcttgat cagctctttg aaagctctct 1942441 ccatcctttc agggttgagc ttcccttcga gctctaacac agccggcata ttgtagcctg 1942501 tccctccgtc ctccagctgc tgaaggacat aaatccgctt ttgggcagag gaaaccggat 1942561 aggtttcctg tttttcagcg ggcttaatcg cttcatatgg actgtccgtt ccttcacgga 1942621 taacggtagc cagtccttct actgtcggat gggcaaacac atcttttagc ggcacctgta 1942681 catcgaattc tttggcgatc cgtgagacaa gcgccgttgc ttttaaggaa tgtcccccgc 1942741 ggtcaaaaaa gttgtcgtga atcccgacag ggccattttt cagcacgtcc tcccacagct 1942801 gagaaagctt catctcagtc acgtttctcg gcgccgtgta ggtctccgca tctgccgctc 1942861 cgccaggagc tggcagggcg tttcggtcga gctttccgct tggcgtaacc ggccactgtt 1942921 ccatctctat catataggct gggaccatgt agcccggcaa cagtctctca agctgtgcac 1942981 gcacttcgtt tctttggagc ccttctacat aagcgcataa ttccggctcc ccgctgtctg 1943041 tccgtacggt aacagccgcc tctcttacgc cttctatgct tcttagtgcc gcttcaattt 1943101 ctcccggctc aatccggtag ccgcggattt ttacctgatc atccgtgcgc ccgaggaatt 1943161 caacattccc gtcagggagc cagcgcgcca catccccggt tttgtacatg cgttcccccg 1943221 ggtaaaacgg gtcttcaaga aaacgctcct ccgttaatgc cggccgattc aaataacctc 1943281 tggcaacacc cgctccggca atgtacagtt cgccggcgac accggaaggc tgtacggcta 1943341 aatgcggatc taaaacatac aaacgcgcac caggtacggg cttcccaatc ggaatccgca 1943401 aacgatccct gtcccgttct ggatccaata cgtaaaatgc cgcgtctacc gttgcttctg 1943461 tcggcccgta accatggatt aatgatacct gcggcaatac agaagcaaaa cgggctgccg 1943521 tacgcggcgc aagcggttca cctccggcga atacacgctt taggcttgtc ctgtcactca 1943581 gcctttcgat ttccgcttga tcgagaaagc tgttcagcat agccggaata aaatgagccg 1943641 ttgtcacgtt ttcctgatga atggcttgta cgatcaatgc ggagtctttc tcccagccgg 1943701 gcggaagcag atacgccgaa gcaccggaaa gcgaccacca aaacagctgc cacacagacg 1943761 catcaaagga aaaagaggtt ttcaccatga caatgtcatc ttccgaaagc ggaaactggt 1943821 gctgcatgcc ggtcagaaag gaaacagcct gacggtgctc aacggccact cctttcggct 1943881 gcccggtaga gcccgatgta tagatgacat aggcgagaga tccgccgtca gcaggagtaa 1943941 actcatggtt ttctgctttt tcgctcgcaa gagatgtcat gtccacttca agcgtttcgc 1944001 cagaaaagtt tggtgcggag catcccggct gtgtcagcaa gagcgatgcc ccgctgtctt 1944061 tcagcatgta gctcagccgc tcctttggat acgcaggatc aagcggcaaa tacgccccgc 1944121 cggccttcaa tacagcaagg acagcgatca gcatgtcagg tgagcgttca gacaggacac 1944181 cgacgatact ttcgtttgtg acgccgcgtg ccgcaaggtg cgcagccagc cggctggcgt 1944241 acatatcaag ctcagcgtat gtcagcgaac cgcctgaaaa gcgaatggcc agccgctccg 1944301 gtgtgaaagc tgcctgtcgc tcaaacagcc catgcagggt gaaagcttta ggcgaaacag 1944361 cttccgtctt gttaaactca tacaacaatt tttgcttttc tcttgtattc gtcatatcta 1944421 attctcttat aaagctgtgc ggatgtttaa gggcgttttc cagtatggta agcagatgag 1944481 attgtattcg tttaatatcc tcaagagaaa acaaggtatt ttgatagtcg aaatttaatt 1944541 gaatggttcc attgtctatc cgttcttgta tttgaactga aagttcgttc gcggtgtatc 1944601 cgctgaaata aagcgctgtt tcatagtcaa aatcatctgc attgtgccac tgaagtggct 1944661 gatactgcat agatataccg ataaggttgt gtaaatcctt ctgttcattt cttaattcat 1944721 ttacaagcaa attataagga aaccgttgat gacgcataac agaaagctgt tccctgccta 1944781 ttgtgcggac aaaggaaaga aaatctgtgt caggatcaac cgttattctg attggaaggg 1944841 aactaacgaa catgccgagc atttcttttt cagcctttga acctctgttg ccatagtagg 1944901 tgccaatggc aagatctttt ttagaagtga ttcggctgat gcatatgtaa aatgaagcca 1944961 taaataagga aatgatattg atcttgtgtt cttcgcagaa gattcgaatc gtttgctcta 1945021 gatcaggtga aagaatgatg gtgtctctgg atgcagatgt gctctgtttt tgtaaggacg 1945081 tctggtcggc taacgagtgg tattccaacg ggtgctcaaa ggtttgcgtc caaaataaac 1945141 ggtcctttgc aaaccgtgga gattgtagat attgactctc tttttcgatg tagctcaagt 1945201 aagaaggttc cggctgatca ggtaaaggat ctttcttttt cattttttga taaagatcta 1945261 taatttgatt tcccatcaca tttaaagaga ttccatccat tatgatatga tggaatttcg 1945321 caaatagcca aacttcatga gagtcaattc taaggaggta aaattgaaaa agaggcgagt 1945381 tgaacagttt aaatggaatg ctcgcttgat cctgaatcca ttgctctatt tctatcattt 1945441 caacatttga aaaatcaatt attctaagtg gataatattt atattcagta aggtgcaatc 1945501 gaggctcaag ctcttctcct tctaacagct gaaatctaat ggcgtcgttg cgggagatgg 1945561 aatgattcag tgctccctcc agagtatcaa gctcaatatt gcctttaaat ttcacacaag 1945621 ctgtaagatt gcaaatgctg gtatctggct ccagcagttc ggtaaaccac actctccttt 1945681 gggcatgggt taaagaataa gtatgttcgc tcaacggatt ccctccagtt ctcataataa 1945741 gaggataaga aaatgtagaa aaaagcagaa aaatgacaat aaaagaaatt atatgactat 1945801 ataatccata tatgcactat attaacggat attttttaaa gtacaataaa aaacattaaa 1945861 tttttataac attttttttg aatatagtat tatttcttta tttttcgttt ctttttttat 1945921 caaatttccg gatataaagt gataaaagta ttgttttaca taaggtctta tacactactt 1945981 tttaatcgga ctaattttct tttgtgcatc attcttctaa ttgttggaag gttcgacaaa 1946041 gcgttattac agacataaaa aaacctgttt tctcttggaa aacaggtctc ccgctattat 1946101 tgatttgcca aaatgacagc gatttgatcc tcaatatctt ttccatcctc ttcatcaatc 1946161 aatccattta gaagaataga gaaaacaagt ttttttccgc tctttgtttc tgcgtacccc 1946221 gatagagagc ttaccgtact gagcgatccg gtttttgctc ttacttttcc ttgtgcagga 1946281 gtgcctttca tgcggtttct cagcgttccg cccaccattc tgtcaggatt ccccgcaaca 1946341 ggtaaagaat ttagataagc cgagaaccaa ctctgatcct gaatgtcata taacagctgt 1946401 gaaagttgat ctgaggatac agcatcaata tgtgagattc ctgatccgtc ccttaagacg 1946461 agtgatttag aatcaacacc aaattccgga agcgtactgt ttaacacttc gagccccttt 1946521 tcccagctcc cttctccttt tttcactttc cccatctctt ttacgagcac ttcggcatgt 1946581 ccgttattac ttaatttcat gaacggcaca aaaagtttcg ataaaggcat tgagcgatga 1946641 gagagcagca catctgaaga actaggtgct tcacccgtct tgatgtcccc tttcacagta 1946701 ataccttgtt tttttagtga ctgcttaaat aaatctaagg catatccggc aggctcccag 1946761 acagaaatcc attcctttgt cttgtttgcg tcaaccggta cgctcccttc aattgtaatc 1946821 gtgtttgttc catgctctct ttcgattgtg aggtctttct ctgaaccggc agcagtcgtt 1946881 ttagcatcgt tctttatcgt tatataatcg gttttcggag agacagacac ggcaggctct 1946941 tccccttctt tttgatttgg ggtgacctca acaatcacag tgcctgcatc atagtcttcg 1947001 tttggagacg ctgttagagc ggagattggc gcgccataat atgtgtattc atcgctccaa 1947061 ggcatatcag gtgataatcg catgtcatca tgccacgtat catcaccgat cagattgcct 1947121 ttaattactt ttacgccgga atgtttcaat atctcagcca ttttgtcaaa atcagatggt 1947181 aaaagtgtcg gatcgccttt ccctttcaaa taaaggttac cattcagctt tttccctttc 1947241 agtgttccat ccgtccggac ctcggttgta aaagaatagt tctcgccaag gacagaaagt 1947301 gccgcggccg ctgtcaaaag ctttagagaa gaggcaggcc tcattcgggt gtctcctgaa 1947361 tgttcatata gaacagcacc tgtttccgca gagcgaacgg tgatgccggc cattgcgcct 1947421 tcgagggcag gatgatcagc taaaatctta tcgatctgcc cggaaagtgc atcttgtttt 1947481 tcagcggcaa gcgcagcctg atgcatataa ggcaccgaag caacgacgaa aagcagtaaa 1947541 acagcaacat aaagctttat gctttttttc attaatttcc ccgcctctct gcgcttcatc 1947601 attggctatt gatgattcag ttcaatggtg atactgcttt tagctgtcgt ttcttctccc 1947661 ggctccagca cttgtaaacc agtgagtgac gaaggtaaat caagattcac tgcgtttgtc 1947721 acccatgtgt aaggctcagg gcataaatac ccttgttttc cgtccgcatt gtatacaacc 1947781 caatgtttaa actgttcatc tgccttataa ataatgctga tatgtgcatg ctgatgataa 1947841 atgactgcct ggttttctcc gcccctcttc tgataagaag ataaaaagac atcatccagc 1947901 tgcttgtggc gcaaatccat tccttcatgc aaagcttctt tatacgggac atccatcagc 1947961 ttcccggtcg gcagcaggcg ttcatccaac tcccattgct gatctgctgt cagggagaat 1948021 aacgagcttt ctgccggaaa tataaatgta gtatgataac caattcccca aggaaacgct 1948081 tcctttcctt tgttcatgac cgtcgcatgt ttaaataggg tattctcctt gatcgtgtat 1948141 gtcatccgaa cgacggcatg atgaggaaat tgcttctgca catggggaag ctcagaaaga 1948201 tcaatttctg tttcaacaat cactccttca tcagtttgct tcgtggtcac gacattccac 1948261 ttttcatggt aaagaaaccc gtgaagatgg ttgtgtttat ccttctcgtt gatatcaaaa 1948321 tgatacgttc tgccccggaa actgaatgta ccgtcactta tgcggttagg cgggaacagg 1948381 attggaatgc catacaatgt tggtgtgtcg tgaaaacttt ctgctgtttc cggttcacgc 1948441 aaaagctgga catttgttgt tttgtccacg agagaaatga cgttgctccc ccactcaggg 1948501 acaacaatca tttctagatg ttcgttgccc gctttgatgg ccggcgttcc caaatacgtg 1948561 attttctcaa taaagtttgc catgtttact caacctctcc ttgattcatt gctagtataa 1948621 gaattcaatg tactgtacca tatttcctcc attttatatt ttcccctatc aaataaaaaa 1948681 acaccgttca aacttatgaa cggtgtgatt cggaggctat tggatgagac gtgtgatttg 1948741 tttctttttc cagacgaatt gataataccc ataaatcaac agcaagctga cggcaaacgc 1948801 agctggataa ccaacccaga cgccgagtat ttcaagcttt gtatagtgag aaaggacgaa 1948861 agcgacaggc acctctactc cccagattgc aaaaatactg atgacggtcg gccataaaac 1948921 tgttccgctt gcccgcatcg ttgcagaaat aatttgggca tttccaaaca gcaaatagct 1948981 ccacagtgta atcatcaaaa gacggtgcgc aatgtaaagc gtctcttgct cggttaaaaa 1949041 taacgataaa atctgatgtg aaaaaacata gatcagaatg atcagtacgc cgccaatgat 1949101 ataattcagc caaatcccaa cgcgaatgac ctgctttaag cggtcaaact cgtttgctcc 1949161 gatcgattgc gcagcgaaaa tagaaaccgc aataccaagg ctgacggccg gcatctgtac 1949221 atagctggcc acctggttga ccactccgta tgcagctgtt gcattagagc cgtaatgatt 1949281 gacgaatgaa ataaccgcta tctctgataa tgagacaaga atcatattga tgcttgctgg 1949341 gaccccaaga cgcagcagga gaaccagcag ttccttatcc attttcaaat aacgacgcac 1949401 tgttttatca aattgcagcg ggtgttttcg ctttcgtaaa tacaccatta acacgagaaa 1949461 agtcgcaatc gtggaaatga cagttgcata tgccgagccg tatatgccca gtttcggaaa 1949521 accaaacatg ccaaggatta aaacaggcaa aagcgcgatg ttgatgaccg tgctcacaat 1949581 cagcgtataa aacggtgtct tggaatctcc tgttccgcgc aaaaaggtag tatatgcaaa 1949641 atataaaaac ataaacggca tagcataaaa taaaatacgt gcatagttag cgctgacatg 1949701 aatgacattt tcaggtgttc ccattaaacg aaggatatcc agggtgaaaa tactgccgat 1949761 aacggctaac acaacgccta ataaaaatgt aaacgtgagt gtcgtcccga caacagcctt 1949821 tagccgttcc tcatttttcg ctccgtaagc ttgtcctatc agaatcgaac ttcctgaacc 1949881 gatcccaatc gtaaatgaga ttaaaagaaa aaataacggg aaaaaggatg atacagctgc 1949941 cactgcatca acaccgagcc atctgcctac agccatcatc ccgactagct ggccgactga 1950001 ttgcagcaca ttgctcagca gaagcggcac taaaaagagt gacatcgacc gccaaactga 1950061 tggtttgctt ttcttttgag ttacaagagg ttcttgtgat gtttccatat taaaggactc 1950121 ctttatttga aatcgttttt aaacatgccc tcattttttg acaaaaacag gatatgtaac 1950181 atgttattat tcatcactgc acttatgaaa cccttcccga ttcttctaat tttacacatc 1950241 tttttagctt atgaagaata aactagcaag taatggcgta ttttttgtga gtaaaagaat 1950301 aaaaaataat ttatgcaaaa gtattgtaat ctatccgtaa ttattgtaac atttgtaaca 1950361 taagagaaag agattttgaa ggagagagcg ataatgaaaa aatgtcttct atttctaaca 1950421 accattgcac ttattctgtc attaagcaca aatgcatttg cgaaaaatac atcaggcgat 1950481 ttatcacaaa aacaagcatt acagttggca ttatccgcta gagaacattt ttggaacacc 1950541 atgagcggcc acaatccgaa ggtgaaaaaa gcagtttgcc catcaggcac attcgagtat 1950601 caaaatcttc aatatgtata catgtgcagt gatctaggca ctaaagcaaa agcggtgaat 1950661 tatttaactc ctatttttac aaaaacagca atcgaaaaag gctttaaaga ttatcatttc 1950721 actgtttcaa aaggaaaact tgctgttcca atcggtgacg gagacaatct tttgaattgg 1950781 aaaaaatcaa ctgctaaact gatctctaaa aaaggcagca caatcacata cgaatttact 1950841 gtccctacat tagacggatc cccttctgca aaacggaaag tgacatttgt gaaagaaaat 1950901 aaaaaatgga aagtcaatca atttgacgca gttatataag aaaaacgccc ggtataagcg 1950961 ggcgtttttt atttggtttg cataaagaaa gacaacaggc gaaaagtgcc tgttgtcttt 1951021 ttgtgaatat aacgctctag gagagattcg aactcccgac ctgcagttta ggaaactgct 1951081 gcactatccg ctgtgctact agagcttttg gtatttatat agtagctctg atgatcaata 1951141 ttttcaagcg atttgtatta aagccctcca aaaaccttat atgcggctct tgtcgtatct 1951201 tcatcaatac cgatataccg cattgtaatt gatggtgatg aatgattcag tattctctgc 1951261 agctcggcga tgtctttcgt tcgctgataa aaatgatagc caaacgtttt ccggagtgta 1951321 tgcgtcccta tctcctcaag tccgcacgct gcagcggcct ctcttaaaat tctgtaggcc 1951381 tgaatgcggg aaatcggctt cctggtccgc actgatttaa aaagatattc gttttccttc 1951441 atgtctttcg tatactcgta tatttcctgt ttcagcgatt ctaaaataag aatctttctt 1951501 ttctttttcg ttttgctttc agtcgcccat aaatgatctt tattttgaac gtccttcact 1951561 tgcagcggca gaatatcaga aatacggagc gcgctgttga tgccgaaaat aaacagaaaa 1951621 taatcccgct tgtttttgtt aagcaaatac tgtttgactt cttggatttt ctctagactg 1951681 cgaatcggct gtacaatatg catcaaaaaa ctccttaaaa accgttatgt aacattttga 1951741 ggtctatgtt actattatag ctgaaaaacg ttgaatgtca aagtgcggcg gcgtttatgt 1951801 aacataatat acatagtgtt acataagctt ttaaaaaagc ttcttccaac cttcacccta 1951861 taaaataagc tttaaagcct cttataaagc ttttaacctc ttggatactt atccccctac 1951921 taatcatcaa aaaacctctt aaaatgaaat ctgacactcc caattttctg gagcttccgc 1951981 aaaaatatac aaaaaaagac acaatttcaa attgtgtcct aatcctcatc ctttacatca 1952041 atatcttccg ggatcggttc atttaatatt tcctgcacaa gtgctttgta attctccagc 1952101 tgttcgagat gcgttttgaa ctgttcctta taaatcaaaa attgctcccc gtcatgaacg 1952161 gctctgattt tcccttcgag caccaagctt ttaatataat cctctgaaag atttgtatat 1952221 tctgctgttt cttcaatcgt taaatacata tagcagtccc ttcttaatcc gtatgctgat 1952281 tctaatatag cacatggctc atatcaatat aatcaattct gcacagaaaa acggcattat 1952341 gcactatata atataccatt tgtcacttgt gaaaacgctg taattttttt acgctaagat 1952401 tgtaacaata cagcttcata taggagggag aacatgaaaa gaacgtggaa cgtctgttta 1952461 acagctctgc ttagtgttct gttagtcgct ggaagtgtcc cttttcacgc ggaagctaaa 1952521 aaaccgccca aaagctacga tgagtacaaa caagtagatg ttggaaaaga cggcatggtt 1952581 gcgaccgcac atcctcttgc ttctgaaatc ggtgctgatg tgctgaaaaa aggaggaaat 1952641 gctattgacg cagcggttgc cattcaattt gcactcaatg taacagagcc gatgatgtca 1952701 ggtattggcg gcggcggttt tatgatggtg tatgacggaa aaacgaagga tacaacgata 1952761 atcgacagcc gtgagcgtgc tccagcaggc gcaactcctg atatgtttct ggacgaaaac 1952821 ggcaaagcaa ttcctttctc tgaacgtgta acaaaaggta ctgccgttgg tgttccaggc 1952881 actctgaaag ggctggaaga agccttggat aaatggggaa cccgttcgat gaagcaatta 1952941 attacccctt ctattaaact cgctgaaaaa ggctttccga ttgattcggt gttggcagag 1953001 gccatttctg attatcagga aaagctttca cggactgccg caaaagatgt atttttacca 1953061 aatggcgaac cgcttaaaga aggagatacc cttattcaaa aggatttggc taaaacattt 1953121 aagcttattc gctccaaagg cactgacgct ttttataaag gaaaattcgc caagacgctt 1953181 tctgacactg tccaggattt cggcggatca atgacagaaa aagatttaga aaattacgac 1953241 attacaattg atgaaccgat ttggggagat tatcaaggct atcaaatcgc tactactcct 1953301 cctccaagct ccggcggtat tttcttattg caaatgctga aaatccttga tcattttaac 1953361 ctttcacaat acgatgtccg ctcatgggaa aaatatcagc tgcttgctga aacgatgcat 1953421 ttgtcatatg ccgaccgtgc gtcttacgca ggtgatcccg aatttgtaaa tgttcctctc 1953481 aaaggcctgc ttcaccccga ttatattaaa gaacgccagc aattaatcaa cctagatcaa 1953541 gtgaataaaa aaccgaaagc cggtgaccct tggaaatacc aagaaggatc agcaaactat 1953601 aaacaagttg aacagccgaa agacaaagta gaaggccaaa caacccactt tacagttgct 1953661 gaccgttggg gaaatgttgt ttcttataca acaacaatcg aacagctatt cggaacgggt 1953721 attatggtcc ctgattacgg tgttatttta aacaatgaat taacggattt tgatgcgata 1953781 ccaggcggag ctaacgaagt acagccaaac aaacggcctt taagcagcat gaccccgacg 1953841 attttattta aggatgacaa gcctgtcctc acggttggat ctcctggcgg ggccacaatt 1953901 atttcatccg ttttgcaaac cattctctac cacattgaat atggtatgga attaaaagca 1953961 gctgttgaag agccgagaat ttacacaaac agcatgagct cttaccgtta cgaagacgga 1954021 gttcctaaag atgtcctcag caagctaaac ggcatgggcc acaaattcgg cacaagtccg 1954081 gtggatatcg gaaacgtgca aagtatatcg atcgaccatg aaaacggcac ctttaaaggt 1954141 gtagctgatt caagcagaaa cggcgcggcg atcggcatta atttaaaacg taaataaata 1954201 aaaaactgta ctcgcttcaa atgagtacag ttttttcatg cagatcttta aaataaaaac 1954261 tgacaaacgt ctttattctg ctaatgcacg tctatcttca tcttttcatt tcgtttatct 1954321 catcaagaaa tgtctgaaac gcactcgtaa taaaaaagtc tttcctgtat ataaagacga 1954381 tctctaagtc ttgatatgat ggtggcagct gatgaatcca tacatttgta cgatgctcgg 1954441 agccgtcaac agcggacttt gggagcagcg ccgtacccat cccggcggaa acacctttta 1954501 taatagcctc caatgtgcca aactctatga ttttttgatt gtgtatgcct gcttcctcta 1954561 gtaatctttt gaccctgtca cgatgagaac agccagcccc aaaaaagagc atcggctgct 1954621 gaagcatgtc ttctgccgtc ccttctcgtg atgaaatcaa aactaattca tcatgggaga 1954681 catggagttg tctaactgca gcgtgttcaa ccggcccata tacaaaagcg ccatcaactt 1954741 tatgatcaag aacctgttga atcaaatgat gcgtatcagc tgtgttcact gataaatcca 1954801 cttcaggaaa acgcctgagg aaggatgctg catgctcagg cagatgcgtt accgccattg 1954861 tttccagtga tccgatccgc aaaggccctt ttggttgcct gctcattcgg gtcgattttt 1954921 cagcttggtc taacagcgat aatacttgat ctgcatattg taaaagattt tctcctgcag 1954981 cagtcagctt cattccccga ttcgttcgat gaaaaagcct gatattcaaa tcttcctcaa 1955041 ggttatgcac tctggctgtc acattcgact gaacataatt cagcatttgg gctgctttcg 1955101 ttatgcttcc ttcgcgagca acagcctgaa aaatctttaa atctccgctt tccacgcgct 1955161 ctcacctgct tgctatgatg aaaagtgata ttggctatca tatttgttca ttttactcga 1955221 agaaaaccgc tatgtaaaat atgtaaagat atgaaaatac aattaatgag gaggcagaca 1955281 gcatgaaagc tgtaattcac aacggaaaag ccggtcttct ggggttatca gttcaggacg 1955341 ttccatcaac aaagcctgga tacggagagg taaaggttaa attaaaatct gcaggcctga 1955401 atcatcgtga cttgtttctt atgaaaaaca aatctgaaca agatcctcac atgatactgg 1955461 gttctgacgg cgcgggtatc atcgaagaga ttggtgaagg cgtgaaaaat gttactgttc 1955521 agacagaagt agtcattttc ccgacattga actgggattt gacagaaaat gttccacctg 1955581 tacctgagat tctgggaggt ccttcggacg gaacacttgc tgaatatgtg atcattcctt 1955641 cacaaaatgc aatcaaaaaa cctgcttatt tatcttggga agaagcgggc gttttacctt 1955701 tatccgcttt aactgcatat cgggctctgt ttacaaaggg gcaattaaaa aaaggcgagc 1955761 atctattgat acccggcatc ggcagcggtg tagcaaccta cgctttattt atggctaagg 1955821 cgattggggc aacagtaagc gtgacctccc gcagtgagga gaaaagaaaa aaggcgctga 1955881 aattaggtgc tgattacgca tttgacagct acagcaattg ggatgagcag ttgcagggaa 1955941 aaaagataga tgttgttctt gacagcatag gacctgccct cttttcggaa tacttccgcc 1956001 atgtaaaacc aaatggccgt attgtcagct ttggggcaag ctcaggggat aatctcagtt 1956061 ttccggtgcg ttctttattc tttcctcagg tcaatgtttt gggaacctcg atgggaagcg 1956121 gtgaggaatt tcaagctatg ctcgctttca ttgacaaaca taagctgcgg cctgtaattg 1956181 accggatata tcctttagaa aaagcatgtg aagcatataa aagaatgcag gaaggcagac 1956241 agtttggaaa catcgggatc gtaatggaat aaaaaaagaa accggctggc agccagaccg 1956301 gtttctctta tatgataatc ccctttattt acggaagaac tgaactcccc atcaaatatc 1956361 gatccacttc acgcgccact tcacggcctt cattaatcgc ccatacgatt aagctttgcc 1956421 ctcttcttgc atcccctgcg gcgaatacac catcgatatt tgtttgataa tccccatatg 1956481 ctgcactgat tttgttattt actgaattaa caccgaactg tttcaacagc ggctgttctg 1956541 tgccttcaaa gccgatagcg ataaagacaa gctgagcagg ccatactttt tccgttccag 1956601 gcagctcgcg gaactcgtat tttccatgct catttttcac tttttccatt tggatggtat 1956661 gaagctcttt cagctttccg tttttatccg cgaccatttt tgtcgtttga atggagtatt 1956721 ctctcggatc tcttccgaat tttgcttctg cttcctcgta tgcatattca agcgtaaaga 1956781 cgtgtggctg ttcaggccac atattgtcat tcgtgcgggc tggcggaagt ttcgggtgtt 1956841 tgccgaattg gtgcacgctt ttggcttttt gacgcagagc ggtagccaca cagtcagctc 1956901 ctgtatctcc gcctccgatt acgatgacat ctttcccttt ggcatcaatg aattgcttgt 1956961 ctttaaaatt agaatctaaa tagctttttg ttgcaagtgt gaggtagtcc attgcgtaat 1957021 ggactccttt tgagtcgcgt ccttcgatta agaggtcccg ctgtttttga gcgcctgtgc 1957081 ataagatcac agcatcaaat tgctccttta gctcatcagc tgtaatgtca acaccgattt 1957141 ctgtgttcgt gacaaaatca attccctctt gcgtcagcaa tttaattcgg cgttctacaa 1957201 tgcccttctc aagcttcatg tttggaatgc cgtatgttaa aaggccgccc gctctgtctg 1957261 ctcgttcaaa aacagtgacg gaatgtcccg cttgattcag ctggtcagca ctcgccagtc 1957321 cggctgggcc tgacccgacg atggccactt ttttgcctgt tcgttttttt ggaattctag 1957381 gttgaatcca gccgttctca aatcctttat cgataatggt ccgctcgatg tttttaattg 1957441 atacggccgg atctgaaatc gctaaagtgc atgatccttc acaaggagcg gggcataccc 1957501 gccctgtgaa ttcaggaaag ttgtttgttt tcaacagacg ttccaatgct tccttccatc 1957561 tgccccggta gacaagatca ttccattcag gaattaagtt gtaaatcgga cagccggatg 1957621 taaatccgtt aatgtccgca ccgatctggc aaaacggtgt accgcaatcc atacaccgcg 1957681 ccccttgccg tttcgatgct tcttctgaaa aaggagcaga atattctttc caatccttta 1957741 agcgagtgag agggtcccgc tccgcaggtt tttctcgttt gatctccata aatccagttg 1957801 gtttccccat gttcctctcc ccttccttac tgtactaccg cttgtttttg tcccgatgct 1957861 gctgtattct gctttggctt cgtgttggcc tcaaaagcga acatgatggc ttcttcatct 1957921 gataaacctg cagctttttg ctcttcgatg cttgcgagca tttgtttata gtttttcgga 1957981 atgactttga cgaatttttt cacactgtct tcccattgat ctagcagatc ttctgctttt 1958041 tggctgtttg tatacgcagt atgtctttca agcattgctt tgatttgctg gatttctttc 1958101 tcatcctcta atgattcaaa taaaatcatc tcaaggttgc atttgcgttt aaacgctttg 1958161 acatcttcgg tcagtacata agcgattccg ccggacatac ctgccgcaaa gtttttgcct 1958221 acatcaccga gaacgacaac gctgccgcca gtcatgtatt cacagccgtg gtcgccgatg 1958281 ccttctacaa ctacgttcac accgctgttt cgaacggcaa agcgttcacc agcacgcccg 1958341 ttaatatatg cttctccgct tgtcgcaccg taaaaagcca cgttgccgat aatgacattg 1958401 tcatccgaag cagagttgaa tccttctgat gacttgacga tgatttttcc gccagaaagc 1958461 ccttttccga cgtaatcatt tgagtctccg tccaaataaa gcgtcatccc tttaggaacg 1958521 aaagctccaa agctttggcc ggctgatccg gtaaagtgca gcttgattgt atcttcagga 1958581 agaccttctt ctccgtaacg ctttgagatt tcactgccgg ttatcgttcc ggctacacga 1958641 tttgtattat tgatttcaat cgaaatatca gcttcttttc cagattcgat ggcttcttgt 1958701 acggccggga gaattgttgt aatatcaagt gattgatcaa ttttatgatt ttgcggcgat 1958761 tggaacgtcc gcaccccttc aggctgataa agaagggtag acaaatcaag ctggcttgct 1958821 ttccagtgct cctttgcccg ttcacttgca tgaagtacat cagtgcggcc gatcatttca 1958881 tcaaatgtct tgaagcctaa cgcagccatg tactcacgaa cttcttcggc aatgaacagc 1958941 atatagttca caatatggtc aggatctccc atgaactttt tgcgaagctc tggattttgt 1959001 gtcgctacac cgacagggca tgtatccaaa tggcaggcac gcatcatgac acagccgagt 1959061 acaactaacg gagccgttgc gaaaccaaat tcttcggcgc cgagcaaggc agccatcaca 1959121 acgtcgcggc ccgtcatgag ctttccatct gtttctaata caacacggtc acgaagtccg 1959181 ttcagcatta gtgtttgatg tgcttctgca aggccaagct cccacggaag ccctgtatgt 1959241 ttaatactgg ttttcggaga agcgcctgta cctccgtcat agccgctgat cacaatgaca 1959301 tctgcagtcg ctttggcaac acctgcagcg attgttccta cacctgcttt tgacaccagc 1959361 tttacgctga ttcttgcgtc acggttggca tttttcaaat cgtggatcag ctgggctaaa 1959421 tcctcaatcg aataaatgtc atggtgtggc ggaggtgaga ttaatccgac acctggcgtt 1959481 gacccacgga catcggcaac ccatggatat accttgttgc caggaagctg cccgccttca 1959541 cccggcttag caccttgagc cattttaatc tgcagctcat cagcattgac gaggtaatgg 1959601 cttttgacac caaaccgtcc ggatgcaatt tgtttgatcg cacttcttct atcatcgccg 1959661 ttctcatctg gaacaaagcg tttgggatct tctccgcctt caccgctgtt gctttttcct 1959721 ccaagacggt tcattgcgat tgctaaagct tcgtgcgctt ccttactcaa ggacccgaat 1959781 gacatcgcac ccgttttaaa acgtttgaca atcgattcag cggattcaac ctcctccaac 1959841 ttcaaaggct tgcggtttcc gtcaaatgcg aacaagttcc gcaaaaatcc gatgcgttct 1959901 tcatcagccg cttttgtata ctgtttaaac agattgtaat catttctgcg gcacgcccat 1959961 tgcaaagtat gaatcgtttt cggattaaac gcatgatgct ctccgccatt tctccattgg 1960021 aagtcacttc ccggttcaag cgttttgctg taatcatcct gatacgcttc ccggtggcgg 1960081 cgctgtgcct cttctgcaat tgtttgtaaa tcgatgccgc ctagctgtga tgcagtacct 1960141 gagaaatagc ggtcgatcac atcgcggctg attcctaccg cctcaaagat ttgtgcgcct 1960201 ctgtagcttt gcacagttga aattcccatc ttggacatca cttttacgac gccctcagta 1960261 atgctttttc catatttgct aaccgcttct tcatagctga tatccaaacg gccttcatca 1960321 atttcctgct tgtaggtcgc ataagcgaga taagggttaa tcgcatctgc gccataaccg 1960381 attaacgctg caaagtgatg cacttcacgt gcttctcccg attccacaat aatgctgacc 1960441 ttcgtacgca gccctttgcg gattaagtgc tggtgcagtg cgcttactgc cagaagcggc 1960501 ggaattggtg tcagtcgttc gttcatcttt ttgtctgata aaattaacaa acttacgcct 1960561 tggctgatgg ctttctctgc ctgtgtgaac atgtccttta aaccgcgttc aagatcctct 1960621 gaaaacagca catcaatttt ttggcttttt aaatcaggat gaacaatcgt tttcaatgcg 1960681 taaaactgtt cattggataa aacaggtgta tacagtttaa tccggcgaac atttcgttca 1960741 cttggatgaa gaagatcgcc ttccgcaccg agccaagtca tcgttgaagt gacaagctgc 1960801 tcacgaatcg cgtcgattgg cgggttcgtt acttgtgcaa acagctgttt aaagtagtta 1960861 aacagcgatt gcgctcggtc agaaagtaca gcaagcggag cgtcattccc cattgaacca 1960921 aggggatctt tgccttcttt aataacagga attagatact tttggatatc ctcatatgtg 1960981 tatccgaatg ccttctggcg agtaagaaga tcactaaatt gttcttcttc tcttgactcc 1961041 ggatcaggat ttacttgtac aagctcttct tcaagccatt tttggtacgg atactcagtt 1961101 gcaatttgtg ttttgacttc ctcatcggag ataatacggc cttcttccag gtcgattaaa 1961161 agcattttcc caggctcaag gcggttttta tataaaacgt tctcctgttc aacttcaata 1961221 acgcctactt cagatgagaa aataatataa tcatcttttg tgacataata acgggccgga 1961281 cggagaccgt tccggtcaag gatcgccccg atttgtttac cgtcagtaaa tgaaatagct 1961341 gtcggtccgt cccaaggctc catcagggag ctatggtact cgtagaacgc ccttttttcc 1961401 ttggacatat gcgtattttc cgtccaaggc tctggaatga gcatcattgc cgtatgtgcc 1961461 ggtttgcgtc cagccatcac aaaaaactca aatgcgttat ccaaaatgga agagtcactg 1961521 ccatcagcat tgagaatcgg caaaatcttg tttaagtcct caccgaagct ttcagaaaca 1961581 aattgctgct cacgtgctct catccagttg atatttccgc gaagggtgtt aatttcaccg 1961641 ttgtgaacca aatagcggtt aggatgcgct ctttcccatg tagggaatgt attggtactg 1961701 aagcgtgaat gaacaagcgc aaaagcagaa acgaatgctt cgtcttgcag atcagaataa 1961761 aatgcatcaa cctgttcagg tgttaaaagg cctttgtaaa caatggtctg gcttgaaaga 1961821 ctggcaaaat aaaaatcaag accttccgtt actccccaat tttcagcctg tttacgaatg 1961881 acatacaatt ttcgttcaaa agataaattg tcctttagat cagaacttgc gccgataaat 1961941 acctgacgga caaacggaca gcttttttgc gccactgttc cgatttttcc gacatttaca 1962001 ggtacagttc tccatccaag aacgacttgg ccttcttgtt caattagtgc attgatttgc 1962061 ttttcaattt tttttctttc atcttccttc tgtgagaaaa agaccattcc taccccgtaa 1962121 cgttcttttt ctggcagatt gatgtttttg cactcttttc taaagaaagc atcagggatt 1962181 tgaaccagta agccggctcc gtctcctgta tccggatcac tgccttgccc tcctctatgg 1962241 tctagctggc aaagcatctt aagtccttgt ttgacaatgt cgtgagtctg cttgcccttt 1962301 aagtgtgcat ataggccgat tccgcatgca tcatgttcaa attcaggacg gtagagacct 1962361 tgagcttttg gcatttgatt gtacgtcata attcctctcc cccgatcaat ttccgataat 1962421 accggtcata aaatctaaca actctataat cattgtaggt tttcaaaacg atataaacaa 1962481 tatataattt agatcaaaag aatctcaaaa tgagatagat ggatgtgaga caaacatgga 1962541 gctgcgccaa ctgcgttatt ttatggaggt ggctgaaaga gaacacgttt cagaagccgc 1962601 tgatcatttg catgtggccc aatcagcaat cagcagacaa attgccaatc ttgaagaaga 1962661 attaaatgtg accttatttg agcgtgaagg gagaaatatc aaactcacgc caatcggaaa 1962721 agaattttta attcatgtga aaacggcgat gaaagccatt gattatgcga aagagcaaat 1962781 tgatgagtat cttgacccgc atcgcggaac ggtaaagatc ggctttccta caagcctcgc 1962841 cagccagctt ttgccgactg tcatttcagc gtttaaagaa gaatatccgc acgtcgaatt 1962901 tttgctgcgc caaggctcct ataagtttct gattgaagct gtcagaaacc gcgatattga 1962961 tctggcctta ttagggccgg tgccgacgaa tttctctgac ataacgggaa aaatattatt 1963021 tactgaaaaa atttacgcgc ttgttccatt aaatcatccg cttgctaaac aaaaaacggt 1963081 tcatttaatc gatttgcgca acgaccaatt tgtattgttc ccggaaggat ttgtacttag 1963141 agagatggca atcgatactt gcaaacaagc aggctttgct cctctcgttt ccacggaggg 1963201 tgaggatttg gatgcgatca aagggttagt gtccgcagga atgggcgtta cccttctgcc 1963261 tgaaagtact tttgctgaaa caacacctcg ttttactgtg aaaattccaa ttgagttccc 1963321 tcaagtaaaa cggactgtcg gaatcattaa accgaaaaat agagagcttg cgccttccgc 1963381 gaatgatttt tatgagtttg tcattcaatt tttctctaag ctggagcagt atcaataaaa 1963441 aaaatgaacc cgagcttcta tatagaagct tcgggttttt ttctgcaaat taatttacag 1963501 gtaaagaaaa atccacatgg caaacaaatg cttcttgatc aattagagct ctatttgtca 1963561 gttccttttt cttttccggt tcttgaagct gtacagaaga gtaattgacg attccaaggc 1963621 cgatttccgt cccttttgaa tccatcagcc gaacaactga accgcttttg aatttccctt 1963681 taatcttctg tacaccgtct aggtataaac tcgattgtcc gtttgttatt tttcgtgaac 1963741 aatcatctga taaaatcatt tcaccttccg gaccggaatt aaaagcgatc cattgctcct 1963801 tttgattcaa cggaagcgtt ccttctgctt caaaataggt gccttccgcc tgttcatgaa 1963861 cggcgtggta taaaatatcg ccagcatctg cctgacctag gaaaccttta atgccagacg 1963921 ccattacgat tttaaacgca tcaagcttag agcgcatgcc gccggtgcca acgatgcttc 1963981 cagtgtcacc tgcgcatgct tcgatgtcag gtgttatttc actcacccgc tgtatctttt 1964041 tcgcttctgg atttgtgcgc ggattgccgt catataatcc gtctatatct gataaaatca 1964101 caagcatatc tgcatcaatc aatcctgcga cttttgctgc gagcgtatca ttgtcgccaa 1964161 acttgagccg attgacggta actgtgtcat tttcgtttat gatcgggatg atgccgcgct 1964221 cgagcagtac attcattgta ttcctgacat tgttgtatcg atattcatca gaaaaatcgc 1964281 ttctcgtaat taaaatttgg gatgcgacat agccgtgtgc caaaaacagc tttgaataag 1964341 cctccattag caatccctgg ccgattgaag ctgatgcttg tttttctgga agcttctcgg 1964401 gcctttggat aaatccgagc ttccgatatc ccgccgccac tgcgcctgag gaaaccaaaa 1964461 tcacttcata accggcgtct ttgagtttga cgacctggtc gaccaacgct tctaattttc 1964521 gaatgctgat ttctccatga aggcttgtta atgaactgct tccaatcttc acaacgactc 1964581 ttttcatgct tgtatcaggc gtcactttat cactcctgat agcggcgctg cagttttttc 1964641 gatatcttcg ctgatttcct ttgaacgctt agccgcatgc tttattgctt gagaaatcgc 1964701 ttctccgccg ccgctctttt tcaaggcttg cagccccgct gctgtcgttc cgttcggtga 1964761 cgtgatatta tctcttaaga tctcaggatg ttctcctgtt tccatgagca tttttgcggc 1964821 acctaaaagt gtctgtgcgc cgatgcttcg agataactgt ttatcgaggc ccgcttcctc 1964881 gcctgtcttt tcaatgaatt ccattaaata ataaaaatac gcgggtccgc tgcctgcaat 1964941 tccggtgaat atatccattt gattttcttg gattgtatag acttcgccca tgcatccgag 1965001 caatgcttcg gccagcttct tcaggtcttc cgacacatat ttgccaaggg caatagctgt 1965061 tgcagaagcg ccaatcatac tggaagtgtt gggcatcact ctgacaaccg gctgttcatt 1965121 aagcaatgat tgttcaataa aagaggtagt tatgccggca aggaccgaca atattaattg 1965181 atggggttga atacgtgatt ttagtgatga cagagcgttt tcggcgtctt ttggcttcat 1965241 tgccaaaatg agcacatcca tgtcttcaat acatagttgg ttcggcaagg cgcctttaat 1965301 gccatattga agttcaagtt cagttaatcg ctctgtattg ctgcggtttg taacgcagat 1965361 gttttgtttc gggattttgt tggctcgaac gatacctgat atcattcctt ccgccataga 1965421 tcctgctcct ataaaggcta ctttcttttg atcaaagatc ggtaacatct cctttgttcg 1965481 cttttttgtt cgcattttca cacgtttaaa atgttaccac gtgaggaaat gatgtcaagt 1965541 ttgaaggcca ttattgattt gtattgtttc ttttcgacaa atatgtataa tgaaaagcag 1965601 aaaacacccg gttcacactg ctgcgccggg tgtttgtttc tattaaaaat tatctgagag 1965661 agctttttca atcagttttt tacagcgatc cagctctacc ttcagctgtt ttttatatag 1965721 cttggcagct tcgtaatctt taaattgata gaggacgact tcctggagct tagccccttc 1965781 tttttttact ttaatttgtt ttagtatccc gtcatcaaga agctcatgca aagaccggta 1965841 tacttctgta tgatttggtt taaaaccaat ctctttaaat tcagaccgaa gtacttcaag 1965901 cagctttaac ccatagagtc tctcttgctc tgtcatcgtt atcatataaa gcttcaaaaa 1965961 tgcgcgctgt ttcactaaaa agcctgttga actccttttt tcttctttca tcatatgcac 1966021 tccttcttct gtcactgaca acactatgta ctaaatattc aattttcttt tattgttttc 1966081 cttctttata ttaaagactg atagtccagt tatttcatgt ttactgatta taggtgtagc 1966141 ggaaaaaata aatttcgact gaacatttgg tacatagttt tcttagttct attatagcct 1966201 gcatttactg ctatcttcaa tttaaacgat tgccagggtt tacatatctc attttaccgg 1966261 tacggatttc attcaaataa aaaaacctgt cgaaagacag gttttcattt ttaaggattt 1966321 gttgaccata atcccgctgt tttgatgaaa atacgaggat ctaatttcag ttgtgccacc 1966381 atgtactcag caagatcctc aggctgcata actttttcag gattaccgtc tgttaagttc 1966441 aattcgatag acatatcact agcgacagtg ctcggcgtta acgcgctgac tctgatatta 1966501 tgttttctca cttcttgcat aagagactct gttaacccga gaacggcaaa tttagaagcg 1966561 ctgtaagcac ttgttacagc agctcctctt tggcccgctg tagatgaaat attaatgatg 1966621 tctccggctt tgcgttcgat catttccgga agcaccgcgc gagtgacatg gtacacaccc 1966681 attaggttga cttgaataat attttcccac tcatcagctg acagatctaa gaaaccgcca 1966741 aatttgctga tgccggcatt attaatgagg atatcgatat caccgagctg ttccttcact 1966801 tgagctacag cttggttaac ctgatcggca tcttttacat ctgcagcagc aaatgcagct 1966861 tttacaccaa gcgctttgac ttcttcagcc actttttcta cattagcgga agtccggcca 1966921 attaacccga tattcacgcc ttctttggca agcgccagag cagtagcgcg gccaattcct 1966981 ctgcctccgc ctgtgattag tgcagtttta tgttgtaaac tttgcaattg aagcaccctt 1967041 tctttgttta catatgtacg atatcacatt ataagtacaa tacatccaat acgcaaatca 1967101 aacgaactgt gtaaatatca tttcttctga ttaaaaaaac ggatacaggg taatgacata 1967161 agaaaaggag tgaacatatg attatagttt atatcagtct tgcagtatta gcagtttcta 1967221 ttatcttctt aggagttacc gtgatccaaa acaagaaaaa aatagacccc gcactaaagg 1967281 agctttcctc tgttacgcag gctatgcaaa aacaaatcga aggattaaaa acagaaacag 1967341 agctgctgac gcaaaaacaa aagaagattc agcaggatgt ccaaataaaa aaatacacgc 1967401 ttcagcagac cgcagctgaa gtgaaagaag ttccccaagc agtcaaagag gtgtggcagg 1967461 caggacattt taatagcaga taaggatgaa tgagatcccg ttgttacgat cagaatggac 1967521 aaatgggatc tcatttttcg aggaggctta cacatgatta taaaccgcag ctgcttaaaa 1967581 gagttcgcag aaaaagtaca ttttcttccc tcttcactta caaagtccga tttacttact 1967641 gatccatttc gtctccatca agaaaacgaa cttggcatct actattcacc tcataatgaa 1967701 tttatcaatc gggatgcctc gcttgtgatt gccgggatca cgcctggttt ttcccagatg 1967761 aagacagcgt acgaaacagc cgccgaaagc ctgctgcaag gcgggactct tgagcaaatg 1967821 gcagtagaca caaaaatagc agcgggtttc tccggatcga tgagacataa ccttattacc 1967881 atgctggatt tatgcgggct gccgcaagct tttggcattc aaagcgccgc aaagcttttt 1967941 ggagaattac ggcatatgct ccatacaact tccgttatta aatatcctgt ctttatccag 1968001 caaaaaaact ataccggata caaaccggct atcactcatt ctcctatcct aagcacttat 1968061 gcttttgggc acttccctgc agagcttaac catgtgacgg gaccagctct tctcattccg 1968121 ttaggaaaag cggccgaaac agtgtgtgaa acattgatca gacagcacag cctccagaat 1968181 ttgatttgcc ttaacggctt tccccatcca tcaggcgcga acggccatcg tttgaaacaa 1968241 ttcagcaaaa acaaagagca actagaaaga caaattcgtt cctttgctgc attggttgat 1968301 ttcgctatag aaaagaggaa ataaaaggga tatgataaac aaaaacacaa acgtggggag 1968361 tggttgaatg tttcctatat tagaaacgga tcggcttata cttaggcaaa tcacagatca 1968421 ggatgcggaa gccatttttg cttgtttctc aaacgatgag gtgacacgct attatgggct 1968481 tgaaaacatg gaatctatag aacaggccat ttcaatgatt caaacgtttg ctgccctcta 1968541 tcaagaaaaa cgcggtatac ggtggggaat tgaaagacgg gacactaaag aactgatcgg 1968601 aacaattggc tttcacgctc tggcccaaaa gcataggcgc gcggaaatcg gttatgaaat 1968661 catcccggag cattggcgaa acggatttgc atcagaagtc atttcaaagg tcgtatctta 1968721 cggattttct gcccttggac tgtcgcgtat tggcgcagtt gtatttaccg ataatgaagc 1968781 atcaaatcgt ctgcttctaa aaatggggtt tcaaaaagaa ggcgttttaa gacagtacat 1968841 gtatcaaaat gggactccat atgatacaaa tgtgtactct attgtgaaac caagagaatg 1968901 acggtattct cttggtctgt gccacatccc ttttccttta aaaagataaa aagcgcccct 1968961 caaacagggc gctttctaat taagatgcat attgaggaga tgtttcctcc ttaactgctt 1969021 tttcctcagg tatatgaata cattttgtca agaccgcact tgcaaggtaa agggccgcaa 1969081 agatccagac gacaccttgc gcgccgacga gaccgatgaa cagccaagcg agtgcagggc 1969141 cgacaaacgc tgataaacct gcagctaaat tcaatacaga catggctgcc cctttatctt 1969201 ttcctgccac cgtcggcaca attgcaccaa tcggcacata gcctgccagc aaaccgcccc 1969261 aaataaagcc gatcacgctg acaaccgcta aacttccgcc ggagaaaaca ggtgcgtagt 1969321 ataataagac ggtgaaaatg ccgcagccga ctccgccgaa ccaaataaca gtatttttcc 1969381 agccgaattt atcgccgaca ataccgaaga taaggttaaa cacaatgttc cccaggaaaa 1969441 tcgttcccca aatttgcagc cacacattgg ttgaaattcc atgctgggcc atgtgcatcg 1969501 gcaaaaagac tggaaaacca tatgtaccaa tgctgttgat gattctgatg attccgcctg 1969561 taagcacgcg cggatttgta aatagaatcg taaccccttt taaaagctcc tcggctgttt 1969621 ctgatctttt tcttttcttc ttttcaaaac ggtctttatt gataaacaat gcaaagaatg 1969681 caccgagaca tacccagaaa atagagctcc aaagcgtatt caaataaccg aacgctttga 1969741 tcgcgtagct tgagtaccaa gcgccgaaca caaacatgcc gaggcaatat gcaatccaaa 1969801 accagccgac agcagtgctc agtttgcttt gcggtgttct gtaaatgacc catgtcaaga 1969861 aagaataagc aaaaagcggg taacctaacc cttttacgaa gtaagtcaca tacatcactg 1969921 gcaggttcag ctgttcaaat ccaaatacga taaaagcagc tgtaccgatc acataaaaca 1969981 acagccccat aaacatcgtt cgttttgcgc caaatgcttc gagacataca cccgaaaacc 1970041 aggaagctat ggcaagcgca attccgtata tactaaaaat ggaagcggac tgctgaacgg 1970101 tgagcccgtt ttcgatcaaa aaaggactga gccagccttg ttcaaggcca tctcccatca 1970161 taaacaaaac aacccctaaa aatccccagg caagccgctt cggtattcct attttatcca 1970221 acatatctgt ctcctcctta gatgctatta ttcattaccg tattacctta ttaaagttga 1970281 aaattaaatg attcctcaaa acagcagaaa ttccgtctta aattaatact ttgctttctg 1970341 atcctgaaaa aaagcgctgt gtttgcttcc attcctcata taaagccaat tctatctgac 1970401 agtccttcgg ttcgatcacc cggacatttg ctgacatctc ctccgttaat tgaaaggttt 1970461 cattgcaaat gactgcagca ccgacgacag atgcctgatg atatccctct tggacataga 1970521 cctttttttg aagaagatcc gcgatatatt gagtgagcgc tttgctttgg aatccccctc 1970581 cgcacaccca aacataatca cgttcaaacg gagtaacctc tgttaaaatg tcaaagttcc 1970641 atttgattga aaatgcgatc tcttctagcg ctgcacgtac aaaatgtgcc ctctttaaat 1970701 gtgctgacag cggggcatca aaaagaaaac cgcctctcgt taacgcattc ttttcagccg 1970761 ataaataaga gccgagagcc gctacacatg catggtcttc ttttgcaagt gcagaaatct 1970821 cctcctccat tacttcgtac gtttcattcg gataaaaaat ctgttttaat ttttgataat 1970881 tcaagccggt aattcccgga ttcgtttcca caagccaatg cccttgatcc gtatgacagt 1970941 tcaaccaggc tttatgtttt gtgtcgccat gatcctcagt aattttggtt attggcgttg 1971001 ttgtccctga tacaatgaca atgtcctcaa gtccagctcc ggtgcttttg acagccagct 1971061 gtgtatcccc gccccctgct ataaccttag catttattga aaggcctaat tcggatgcat 1971121 attcatttgc tatcgttcca attgctgttc ccgctcttac aagaggcgga aggatagatg 1971181 gagaaaagcc gaaaatgtcg cacatctctt ctgaccaagt gttttgcttc acatcaaata 1971241 gcagggtttc tgttgcctgt gatggttcat atgttaatat tccgctcagt tggtacgtca 1971301 cccaatcact gatgcttgta aagcttgcag tcttttccca taaagagggc tggcgctgtt 1971361 ttaatccata aagcttgagc gcagaaaaaa gtgcagttgg caggcggcct gtgctgctgt 1971421 atatctcttc ccaatcggga atgcccgcct cccactctcg gccgcgatta tcgatgttcg 1971481 gcagcccgag aaaaggattg ccgttttgat caatcaaaac aatcccctgt ctttggctcg 1971541 tcgatgtcaa accaatgatg tcaatatcac acgaacggga tagcgcacgt tttgccaaat 1971601 tcatcacctg cttccacagc acctgaggag aaaaataacg gctgtccggg taaagcgtct 1971661 ctgtggaata ctcgatgtcc tcccgttcaa ctgttagaac actgccagtt acactcacga 1971721 ccgctaccct cgcattgcct gtgccaatat caaaaacgag atagcctttt tgttttttca 1971781 ttctgttagc ctcctttctt atccccctgt tttcagtgcg tccttgttat acattgtctg 1971841 aatattaaga gttttttcac ccttccactt tttgagggct ttattcagta tcgtcacgtg 1971901 atgatcctcc acttcaaatg ttgctccagc gagatgcggt gttgccagaa cattaggcaa 1971961 tgaaatcaat tcataatctg attcctctgg aggttcatga taaaaaacgt ctagtatcgc 1972021 accgctgatt ttatgttctt ttaatacaaa taaaagatct tcacggttta caacaactgc 1972081 tcttgaagta ttaacgaaaa tcgcactctc tttcatcaga tcaaaatatt gccgatctat 1972141 cagtccgagt gtttcctcag tgcgaggcag atggacagaa acgatatcgc tgtctgaaaa 1972201 caccgtttta agagatgctt tttcatacaa cggatgatcg tcttgaatgt atggatcgta 1972261 atattttatc ttacagtcaa acgcagtcag cagttttgca atcctttgcc cgactgcgcc 1972321 gaacccaatc atgccaaccg tttttcctgt tagctcattt cctttaaatt tgacataagc 1972381 ctgcaggtaa tcactgtccc actctccatc cttcagccac tgattcgagg cgctggtatg 1972441 gcgcagaaag gaaatcacat ttccaataaa catttcggca acggcttgtg cattccgccc 1972501 tggtgtataa aaaacaggta tgcccctttt tgaggcagct gccacatcca catttgaggg 1972561 cattcccctg caaacaccga caaatgaaag ttcgggaaca gaagcaaata cgctgtctgt 1972621 tacctgatca agttcagtaa tcaagcctgt cgcatttgtt gcttttagca gctgaatgag 1972681 ttcatcctcc cgatatgccc taccttgttc cttccaagat tgataagcaa ctgagccaaa 1972741 caagttttca agctcttttc gtccttcttc gttgtacggt gctgtaacca aaaccgtcat 1972801 gctgcaaaac atccttttca tcgtattttt cataaaaaaa atctctttcc gaagatggaa 1972861 agagattcat atataggcgc gctctgttac aggcagacgc cggtataaac cttgctttcc 1972921 tatctttcaa gctagcgctt gctggaattg gcacaataat gttgccgagg tttcataggg 1972981 ccagtccctc cacctctctg gatagaaaat attgagtatg taattttcag aatgaagaat 1973041 acgtttatca taaagaagac tcagattgat gtcaatctct ttttttcaga attgacgtta 1973101 tcatcggaaa tgttataatt cttacaaaat atctaactag agagaggaac tgggccatga 1973161 gatcttttgc cacacaacaa aacggcattt tcaaatccgt ttgctcgctg gactgcccgg 1973221 atcagtgcgg attgttaata cataaaaaag acgggaaaat cgtaaaagtg caaggagacc 1973281 ctgatcatcc tgtcacagct ggaaacatat gcaacaaagt ccggaatatg acggagcgca 1973341 tctatgatga aaagcggctg actacaccgc tcaaacgaac aggtgcgaaa ggccaagcga 1973401 tatttgaacc gatttcctgg aaagaggcaa tcgatacgat cacctcccgc tggaaacagc 1973461 tgattgatga agagggagct gaaagcatac ttccttacag cttttacgga aatatgggga 1973521 aattgacagc tgaaggaatg gaccgccgct ttttttaccg catggggtca agccagcttg 1973581 aacggacgat ttgcagcaaa gcgggatctg aaggctataa atatacaatg ggcataagcg 1973641 cgggaatcga tcctgaggaa accgttcata caaaactatt tattttttgg ggaatcaacg 1973701 cggtcagcac aaatatgcac caaattacga tcgcccaaaa agcgcgaaaa aaaggtgcca 1973761 aaattgtcgt gatcgatgtg cataaaaatc aaacaggacg tcttgcagat tggtttatcc 1973821 caataaaacc gggaaccgac agtgcacttg ctcttggcat catgcacatt ttatttaaag 1973881 aaaaccttca tgatgaagca tttctgtccg agtacacggt tggctatgaa gagctccgtg 1973941 aacacgtgaa acaatatgat cctgaaaagg tatcgacgat caccggtgtc agtaccgaag 1974001 atatttaccg actggcaaaa atgtacgggg aaacctcccc ttcttttatc agaatcggaa 1974061 acggacccca gcatcacgat aacgggggga tgattgtaag gacgattgcc tgtcttccgg 1974121 cgatcaccgg ccaatggctg cacacagggg gcggcgcaat taagcataac agcggaattt 1974181 tagaatataa cacaaatgcc ttgcagcggc ccgacttatt gaaagggcgc accccgaggt 1974241 cgtttaatat gaatcagctt ggcagggtgc ttttggaaac agacccgccg attcgctctc 1974301 tatttattta cggaacgaac cctgccgtcg tcgcgcccga agcaaacaaa gtcagacagg 1974361 gcttgctgcg ggaagacttg tttactgtgg ttcatgattt gtttttaacg gaaacggctg 1974421 catatgcgga cattgtactg cctgcaacat ccgcttttga aaatactgat ttttacacct 1974481 cctactggca ccattacatt cagcttcagc agccggtgat tgagagatat ggggaaagca 1974541 agtctaacac tgaggttttc cgattactgg ctgaagccat gggattcaca gaccaggagc 1974601 ttaaagattc agatgaagta ttaatccgcc aggcgcttga ccatccagat aatccgcatt 1974661 tggcagagat tgattacgat tcacttacta agcattcatt tatgaaagcg aaacgtgaaa 1974721 agccgctgtt tccgggcgaa cttccaacgc caagcggaaa aatagaatta tattcagaaa 1974781 aaatgaaaca agacggcttc cctgctttac cgacatatac acctcttgta accgataatg 1974841 aacatccgtt tatgtatgtt ccggggccaa accataattt cttaaactca acattttcca 1974901 ataatgaaaa acacatcaag cttgaaaaga cgccaaagct ctttatcaac acaaaagatg 1974961 ctgaaaaaca cggaatcgtt gatggggcac ctgtacgaat ttggaacagc cggggagaat 1975021 gcgagctgac cgctgcagtt ggagaacaag tgctgccagg tgtcgttgtc agccaaggat 1975081 tatgggcgga tgaacaagga aaaaaacagc ttgtaaacgc gctaacccca gatcgcttgt 1975141 ccgatatggg cggcggcgcc accttttttt caggccgtgt acagattgaa aaggtttgaa 1975201 aaataatgaa acccggagta tgccaagccc gtataacata acatcgacat aatggaggca 1975261 tacacatgga cgttttttta ggaattggta ttgctttggc tggatatttt atcggtgaag 1975321 gcttaaagca gaggaaccaa accaaaggta atgaacaaaa tgatatcttc ctaataaaag 1975381 aacgggatat ttacttttac attggacttt ttttaggaat aacaacgact gaagcaaaac 1975441 agttagctgg agacatggca gacctgcctt acatcgaaat aaacggaaaa aaatatgtcc 1975501 agaaacatat gttaaaagat tggacattca cattagttga aaaacatcag ggtgaataaa 1975561 acaaatctga ggagagcgag attcattgtc acgctctcct ctgtttagct gtatggatcc 1975621 tgccaccaaa actttgtgct ataagcgctg ataaaacgat aaaccaccat ctatgttctt 1975681 tcctcaaaca actcaagatg cccgttccac aacaatagtt tttatattcc tttgatgacg 1975741 tgatgttctt gatgaacgta tgtatcgtaa aacacttaga aaacctattc ggtttgaatg 1975801 tgtgctctca ttatgccccc atactgcgcc tttatccgcg gaggattttt ttaaaaaaat 1975861 atgaaaccta aagcttttag atcctgaatt tttattgaac ctccatattt ctccgattgg 1975921 taaaaattag cctatacacc ggaagctgta cgtttataaa ggatcagaga atcccataac 1975981 cagtaaatca ctgcagccgc aatacttaac atataataaa agtacgattg caatgtccat 1976041 gctattgacg caggttcatt gataacaaaa aacaggaaag ctgcgataaa agcaaccaca 1976101 ctgtaaatca ataggtacat gacattgaaa gttctcgctt ttttctgcaa cttcatttgg 1976161 agcggaacag caaaaaggcc atacaccaca aaaccgtata ataaagcaat tgctgccgta 1976221 aacaatgcaa ttatcatatc gccatacata acgaaagaat aaaaccctaa taacaaacca 1976281 aatgtaaggc tggatagccc taatgtcatt aaataatatg atgcgatttt tttcattttt 1976341 tcacccccct tgtttgattt attcacagtg ctgttagtat aaattcacaa cctttgtatt 1976401 tcttttatcg agatgtcttc cctaacgtgc tatacgcaat gcgctaataa aaggtttcaa 1976461 aaatgacgtt cttttattag ataatacgct ggctgaaaac gcctctcctg attggccaaa 1976521 gcgcgaatga aaaaagtgca tgaatacctg cccaacagac agaataagaa gagttgatat 1976581 ttcaacactt ttcgtaaagg ggtgaaacca atgagtaaga aaggtattca aaattcaagt 1976641 attgaacaaa taagaaatga ccatgagact gaaacagctt ttaaagcaga tgatcctaaa 1976701 aaacacggtt ccgatcctaa aagaacgaaa taagttctta cccccactaa aatatcaata 1976761 atctggagga agtaaagtga ctcaaaaaaa cggtgcagac agacctgatg attataaaag 1976821 attttcttca ttagacaagg aatatgattt tcagcaatct atacgcagca atactgagac 1976881 agaaagtgta aacactgaaa cacaaactca taacaaagaa aacaaaaatg acacaacaga 1976941 tgttgccggg aaatactttg agccctcaga ttataaagga agcacgcaat tagaaaaagg 1977001 attggctgaa actcatgaac aggtcagcga tgactatttt gaagggacaa tcgatcaaaa 1977061 tttggactag ccatacaaac ggaactaact taaaagaagt cagttaactc tgtttttaga 1977121 aacaaccaca gtaaaagtag ccaaccccca ccgaataaga tgggggttgc acgtaagtag 1977181 cctgtttaat atttaaaacg attaatgacg gtttgaagtt cttctgccaa ctgagataga 1977241 gattctgcgg cataggagat ttcccccatt gaatgaagct gttcctgtga tgaatttgca 1977301 accgcttctg tatttgctga cgtttctttt gtaccagcag ccaatgtatg aactgtgtgc 1977361 tgaatcactt caacgcctga agtaagctgt tgagttgctg ctgcaacttc ttgtatttga 1977421 gaagtgacct gttccaccag gttcagtatt tcattgaaat ttcctgttgt ctcttgagaa 1977481 agaacaatac ctgagctcac attttcttga acaactttaa tattatttac cgtttctatc 1977541 gattcgtttt ggatggtcgc taccaccgat tggatgtggt ttgcagattt atttgtttca 1977601 tccgccaact tccgaacttc ttctgccacc acagcaaatc cttttccttg ctctccggct 1977661 ctggccgcct cgatcgctgc atttagtgcc aacaaatttg tctgctctga aatcgtcgtg 1977721 ataagcgaag agatatcgct gatttctgct gtgctcgcta ccaatgtttg caatccattg 1977781 ccggctgaat ctacagattt atcaatgaat ttcatctggt ctaacatctt gttgacggac 1977841 ttagagccta tttcagcctt gtctctcatc gaagaagaaa gatccgctat gttccctgta 1977901 tttgaagcga ctgatgatat actgtctaat aattcagtga tggattctgc gctcttttct 1977961 gtcattgagc tttgcttcac attgctgtcg gcagccatct gcatggctcg tgaaatatgt 1978021 tcagatgttg atttcgattc ttccgcgctt gccgataatt cttcagagga agcggcgact 1978081 tgttcagatg agctgctgat ctgcttcaca atttgagtta atgaatgagt aaaagaatta 1978141 aaagattggg caagctggcc aaattcatct ttatttttca caatgacttt tttggttaaa 1978201 tcagcctcgc cgtgtgcaat ttcctccagc tgcttattta tgcttcttag tggcaccata 1978261 atggacttta acagcattat gcttagaaca atgcctaata ttactgatat ccctgtgaca 1978321 atgataatga gcgattgact cattttccca ttgccctgta tttcatcctt tagatcctct 1978381 acctcttgat ccaggcgatc agacagctta ttgacagccg gagctacgcc ttcttttctt 1978441 attgttcttt cttctccaaa atggatggtt tctgcttttt taggatttga agagtaggct 1978501 gttactactt gctgattcaa agctctatac tgagtaaaac ttgtcttaat gtcttcaata 1978561 ttggattgat acttctcttc atcaatcaag tcattaaccc ggtcaaggct ctttaagaca 1978621 tcgtctgctt ttcccttcat accctcgtcg tattctttgt ctctggtaat caagaagcct 1978681 ctttcatcat ttgataaccc ggtcaattca tattggatgt gttttatctc tttttggaat 1978741 tccattttgt ctttaagttc ttcattcttt ttcacagtag aagaaatcat aaatactgag 1978801 gagcctccaa ttccaataat tgaaacaact aatattgata taatccccag caattttgtt 1978861 ttcactttca tgtgtcgttt tccctttccg cacaatgtaa tggctgaaat aaaatatgtt 1978921 caagcgcgtt tgaatccaat tcgcttacgc tcatgtccat aatatcgaca cgtgttatca 1978981 agttttatag tgatattctt atatgaataa gcaaattctt tacgtctctg aacttacaga 1979041 aaaaccttaa gtaaaatttg cagtcttttg cggtatgtaa gtcactctta ttcgtttttc 1979101 taaaaaaggc ttttcccacc tcaaattggc tgaaccggct gttttctcga aaatataata 1979161 caatacgcag cataatatga aggagcgaaa cttaaatggg gatcatcaat ggtaaagaat 1979221 tcattgaccg attgaataaa ctagaaaacg aaatatggta tgatggcgaa aaaataaagg 1979281 gtaacatttc tgagcatcct gcatttaaag gaataatcaa aacaaaaagc tcactttatg 1979341 aattgcaaac aaaggatgag ttaatacatg aaatgactta ttgccttcct ggagatcata 1979401 atcgaatcgg cctttcctat ctccagccta aaacaaaaaa tgatttgaaa aaaagaagga 1979461 ccatgattga acattgggct agacatactc atggaatgat ggggagaagt ccggattaca 1979521 tgaatacggt tatgatgagc tttgcttcgt cagcggagct tctaaaagat aaagagaatt 1979581 gctttcctga acatatacta gatatgtatg aacaagctgc taagcatgac ctttccttta 1979641 cccatacatt cattactccg caagtgaacc ggtcacagtc ctattttggg ctaagtgaaa 1979701 aaccgatatc tgctaaagtc attgatagaa ccgaaaaagg tttaatgatt catggcgcac 1979761 gactgcttgc cacacaaggc gggttgaccg atgaaatctt ggttttttca gcgcctaaat 1979821 ttttctttga aacagatgaa gcttatgctt tttcaatccc ttctaataca aaaggcgtaa 1979881 aattcatcac aagagaatca tttgtattaa gcgactcttc ctttaatcat cccttaagct 1979941 caaggtatga agaaatggat tcaattgtgg tttttgatca tgtgttagtg ccgtggaatc 1980001 gtgtgttttt ttacgataat gtggaagcag ctaaagattt tatgacaaaa agctcttttc 1980061 atgcctttac ctttcaccag gttgtcatta ggcaaatgat aaaaattgaa tttctattag 1980121 gtgttgcaca gcttcttgtc gacaccatta atgtttccga atatcagcac atccaagaaa 1980181 agctctcaga aatcattgtg ggattggaaa caatcaaagc cctcattgac aaatcggaaa 1980241 atgatgctca gttagatgaa ttcggctata tgcgcccctg tttaattcct cttcaagtca 1980301 tcagtacgat cattcctaag ctatatcctc gatttactga aatcatacaa ttaattggag 1980361 ctagcggaat ggtgacactg cctaccgaaa atgcatttga ctcagagata cgggaagatc 1980421 ttgaccaata tcttcaagca accaatacaa atgctgaaga acgtgtgaaa attttccgtt 1980481 tggcatggga tttaacaatg agttcattcg gaactagaca aactcactac gaaagatatt 1980541 ttttcggaga tcctattcgg atttcaagca ggctgtatac cagttatcca aagcaggagc 1980601 agttgaacat gattaaaaca tttttacatg cagatacaga acattgaaaa aacagcggga 1980661 aaagatccgc tgtttcgtat tttttattca ggaaactgaa catggcccgg tactgtatag 1980721 gctttggacg ttccgctttc aggcagcttt ggaatggtgt ctttcacaac ttttccgcgg 1980781 atgtcagtca ttctgacttt gagagagcca gtacctaaat tcgtactcac aaaatggtta 1980841 tagtccattt tctccatgtt gatccactta ccatcctttt catattccat tttcataaca 1980901 ggatacttgt gatttctgac ttggattgct gcccaccacc tgctgctgcc ttctttgatc 1980961 cggtacgtga aattgccggt gattggggct ttgacaacac gccatttaat attgattttt 1981021 ccgtctttca tattgccgat tttacggaag gcattaggtg acagatcaag agctccccga 1981081 gcgccttcgg gataaagatc agtaacatat acggttgttt tcccttttgg cccttcaact 1981141 tccaaataag agccggcaag tgccgctttt actcctccgt aattgagatc cgccggattt 1981201 attgcagtaa tctccatatc ggaaggaatg ggatccagca ggaaagctcc tcctgaatag 1981261 cctgaccctg tatacgttgc ataaccttca tgcaggtcgt catatgctgc cgaagcttgc 1981321 ggggaaaaac agaagatcgt caacaaaacc ataccaacaa atgcactcat gatctttttc 1981381 atatttggtc ctcctcaaac cagacttcaa atgagaatca ttatcattat aagactcaat 1981441 ccatctggtt tgaaagagga aatagattca tagttgattt taaggcaaat tcactatcat 1981501 tcatatatca aatgtaggta cttatgaaaa agccaataca aatgaacgaa tgtgcacttc 1981561 agccgaatgt cttatttttc cctctcaaaa ttcgcatttc aataacgaaa tgaaacaggc 1981621 tgttggcctg ataacagcta tacaggaaaa gctatttttc cccgctcagt ttcaacttag 1981681 ctgtcatcat gatgccaaag atcagcacaa tcggaaccca aataatgaag tgataaaaat 1981741 caggctcagc cagagcaaca ataatagccc ctacacaata caaaataata gccagtgctc 1981801 ttaacacagt atctcttaag aaagtcttct tttgcttctt aaaaaacaaa cggccggata 1981861 tatcctctaa aagagaagcc aaagtgccgg tcaacacagt tgaagaaata cctgcaatcc 1981921 ccagtttttt tgctgctgta gtttgaatcc ccatagaaat gctcatgagt ataattagaa 1981981 tgtgcacagg aacaaatgcc cggtaaaaag aaagacaagc aaagacaaac aaaatgaatg 1982041 cttcaagtgc gagggctttt gtcacagcag aaggccaaag ggtattttcc gcctttccga 1982101 ccatcaatgt agcaatgatc acgccgcata taaatccgat tagcgcagtc aaggaattaa 1982161 aaacagtgac ctgaatggat ttgccgatag ctaaccccaa taatacaatg tttccagtca 1982221 tattagctgt gaacacatgt cccaggctta aatacccgat tacatccacg attccagctg 1982281 ttaaacataa aagtgatagc aaggtgtttc gataagctgc tgcagtcaac ggtgtatcaa 1982341 tcctttcttc tatttcaatt gttagtatgt cttttggcgc aatctctatt ttttaagtaa 1982401 cccaacatta attaggaaga tagaacctat tattcctttc cattaactgt aataataatc 1982461 cccgcaagga aatgattaaa attgaaagga agcatattgt gatgaaacga ctttgtttat 1982521 ggttcaccgt ctttagcttg tttttggttc tcttgcctgg aaaagcatta ggtgcagtcg 1982581 attttccgaa tacctcaaca aatggccttt taggttttgc cggaaatgcc aaaaatgaaa 1982641 aaggcatctc taaaacgggc acaacgggtg gaaaaaacgg gcagattgtt tacattcaaa 1982701 gcgtaaatga tttaaaaacc catctaggag gatccactcc gaaaatttta gtgcttcaaa 1982761 atgatctttc cgcatctgcg aaaacaacag ttaccattgg ctcaaataaa acactcgtgg 1982821 gctcttacgc gaaaaaaacg ctgaaaaata tttatttaac aacttcatca gcttttggaa 1982881 atgtcatttt tcaaaattta acgtttgaac acagtccgca gattaacgga aataatgata 1982941 tccagcttta tttagattcc ggtatgaact attggattga tcacgtcaca ttctcaggtc 1983001 atagctataa tgcaagcgga agcgatttgg acaaactcgt gtatatcgga aaatccgcag 1983061 attatatcac gatcagcaac tcaaaatttg cgaatcataa atacggtttg attttaggat 1983121 acccggatga ttctcagcat caatatgacg gctaccccca catgacaatc gccaataatt 1983181 attttgagaa cttgtatgtt agaggcccag gtctgatgag atacggttac tttcatgtta 1983241 aaaacaatta cagcaataat tttaaccagg cgattacaat tgctacaaaa gcaaaaatat 1983301 attccgaata taattacttt gggaaaggca gtgaaaaagg cggcatcctt gacgacaagg 1983361 gcactggtta tttcaaagac ataggcagct atccatcact caacaagcaa acctctccgc 1983421 tgacttcttg gaatcctggg tcaaactata gctatcgtgt ccaaacgccg gaatatacaa 1983481 aagaatttgt cacgaaatat gccggatcac aaagtacaac tctggtattt ggctactgat 1983541 ataaaagagg ccctgcgtta aaaacgctgt gcctcttttt atactatagg ctatttttaa 1983601 gcgatccttg taattccatc aagatccagc gtcggtcaaa ctaaaaagca tatgttcttt 1983661 tccacaataa cttcttaact ggctttctta ttataccagt ttatcgcaag tgaaaagaaa 1983721 tcattgttct gaacctgtat taaatgaacg atcgtcccac aaactactta aaaaccccta 1983781 aaaaggatga tggatatgtg cggcaggttt actttgtact ctgcatttga tgatattatt 1983841 gaccagtttg acatcgatca attttttcct aaaggtgaat accagccaag ctataatgtc 1983901 gcaccatcac aaaacatcct tgcaatcatc aatgatggat caaataatcg cttaggcaag 1983961 cttagatggg gacttattcc accttgggca aaagatgaaa agatcggtta taaaatgatc 1984021 aatgctcgag ccgaaacaat taccgagaaa ccggcctttc gaagaccgct tgtcagcaaa 1984081 cgctgcatca taccagcaga cagtttttat gaatggaaac ggcttgattc caaaaccaaa 1984141 atcccaatgc ggatcaaatt gaaatcatct gctctttttg cgtttgctgg cttatatgaa 1984201 aagtggagca cacatcaagg ataccctctt tatacctgca ccatcataac aactgagcct 1984261 aatgagttca tgaaagatat acacgaccga atgccggtta tattggccca tgatcatgaa 1984321 aaggagtggc ttaaccccaa aaatacaagc cctgattatc tgcaaagttt gctgctgcct 1984381 tatgatgctg atgacatgga agcataccag gtttcatcat tagtaaattc acccaaaaat 1984441 aattcagctg agcttcttga tgcagaaaat catatgtagt gattgaaaaa attctctagc 1984501 aagaacttgt caaatagctt tgttccttag gtgccaatcc ctctagtaat tatgaatatt 1984561 tagtacatag atcaattagt tatctttagc atcagtttga aataatttta ttatgtaaac 1984621 ttaaataagc aatgttattc ctttcatata aaatagttta catttttata aaatcgcttc 1984681 acttttctat tttgtcagca aaaaaactga accacattaa acttatgaaa cctgccgcac 1984741 ctgtggattg caaatatgat ataagcccat agaggtaaat ccatacactt tccctcctaa 1984801 gaattaaatg aaatttcttt catcttacat gaaggtcttc tttcttttgt ttatccagtg 1984861 taatacttaa taatatgttg atgaatgcag ctggaaaata tataaatccc actccaagaa 1984921 tgcctagtat cgtacttaaa cttactatgt aattctttgt catcgtttga ctgtcaatca 1984981 atattagaag tgaaatcaat ccagctaaaa cacctataaa ccaagcatcg ccaacagcat 1985041 aagaatcatc cagcatccct aaccatcgcc ccaatataga gctcccaatg gcagtcaaac 1985101 tggataaaaa tatgagtgct ttcatttctt ctcctccttt aaagccaatc aaactggtag 1985161 aaatcggcca ttgaatcccc attatcgaat ggttaccatt tcatttccac attaacattt 1985221 taaagctcat tacaatacga ttcaagcaga aaaaccctac ataacgtata tatagggatt 1985281 taataaaaca caggccaaaa ttcagctcta tctactttaa aaagatatga agggcagctg 1985341 tgtgatctgt tacgtcttta cgtaccggga tatttcacaa caggcacttt cttcttgcgc 1985401 agagaatcaa gcatgactga tccagcattc aagttgcttt gtactaattc tttaggcgtc 1985461 aatgccatcc actgattgag tgacacatct gcatagcggt tacttttgaa catttctaaa 1985521 aaccataatg tttctgtacc agtgttttgt atatagtgtc cggcattaga aggcacgtat 1985581 ccaacgtcgc ctgctctata atcaaatgtg cgggcagtcc catttccgat aaataccgtc 1985641 attcgtccct gtcctgttag ataatattgc cactcatcgc tattgggatg ccaatgaagc 1985701 tctctcatcg cgccaggctc aatctgaaca agtgcagcgg ctatcgtttt tgaaattggg 1985761 aagttagaag aatccacaat tcgtacactc ccccctggca tttgaattgg gggttgattt 1985821 aacagctcgt gtttaaaggt catggggact tttccatatg gtgactgaat gtcttcactg 1985881 gcgactgatc ccggcacatt cccttggtag atatagactt gctcagacgg aagagagttg 1985941 aaagcattct ccgggacacc gaaatttgca gacagaacat cttttggtgt gtgtgcaagc 1986001 caatctgaaa tggttaacgt tgaaaactca gaaaagttcc catcatcgaa aacgagcaga 1986061 aactcgcagt gttccaatcc ctgtatggaa tgcggaattc ctgccgggaa gtaccaaagg 1986121 tcgccgggac caacatcagc aatgaaattt cgtccgtctt ggtcaacagc ggtgatacgt 1986181 gcccgtccca aaagcatata agcccactcc gcttgcttat gccaatgaag ctcgcggacg 1986241 cctcccgcag ttaagctcat gtttacacct gcaatcgcag tcgaaatcgg aagctgtctt 1986301 acggtgattt ctcttgacca gccgccgtga tctaatttca tgggagcgtc tgagaatgaa 1986361 aatctcaagt taggaatcat accctcatct gtaacaggcg gaacaaatat attcggattt 1986421 tgaatatccc gtattatatt tcgcgggcct gtatcaatag ctccagctcc atcacttcga 1986481 ataggctgcg gcacgtttct gtcttcatga ttgattggtt gttgttccaa cagcatgcac 1986541 ctcgttttag aaatgaacaa gattttattt cagcctatgc agaatcttag attgctgtgc 1986601 ctaggaatcc gcaaataaaa aagtgaccac caatgtgatc acaaatacat caaataaact 1986661 attttttata ccatggcttc ttatgtaatt tgattgcttc tgtctgtttt ttctggcctg 1986721 tcctccactc cacttttact aatacatcat gacctatcac ttcatcttca ggcatataat 1986781 caaaggtgga aatatggtcc tccatgcgtc ccccacccgg catttcatca cctgtgtact 1986841 ccgataagtc gtactcatct acgttatcat cttgatactt ttcgccatct acatacagag 1986901 taattctttc aacaacagtc cacttttctt ccttcttact cccctgccaa tatagattta 1986961 gaaaataatt gggtccaatt gaagttttgt ctgatttttc aaggttagac atccacagtc 1987021 cgcttttccc gctgccctca tatttcactt tgttccctga caccattaca aataatgtga 1987081 tgatgcagat gatcaagaat ccagcaatga tcaatagcca tttcttaata ttgttctttt 1987141 ttctcatgtt tttcctcact ttcctaactt tttagtagga aaatacgatc aaaatgttac 1987201 cgaaaagaaa ataagaaagg gctaatgatc taacagatga ctgtctaaac ttttgactta 1987261 aattaaagtg ctttctaaag acaagattaa aacgtataac agctcttaaa tgcatttttt 1987321 gtttcattga gtcaagaacc ttaaaatggc tttttattat taaaaatcaa gctagtgtat 1987381 taagtaactt ttcaaattta tttatactca tgatctcgtg agtcacaaat ctcccatcaa 1987441 aaaaaacgct aaaagttgtc caaatagctg gtgacttttg tgcctcttct ttcgatgata 1987501 actgaattga ctgaaattga acccctttct tttcagtcaa ttcccgcaaa tcatttatca 1987561 tgcccactgc aaacggacac tgagctgtat agtatatcgt aatccccttt tcattgatag 1987621 aatcactttt cacctggctc ttaaatgcag gagaatctgc aaggccattc caagtcaaag 1987681 ccattaattg aaaataaggg gcagcttcat cttgtagagt aaaccccata tgctcaaaga 1987741 aatgcttatc acttaaatag ggcagttttt tcttgcctgc gatatggata atgccatcca 1987801 tgccgcacgc tttcgcatct gctatacatt tgtccaacaa tcgtttcgca tgaccgttat 1987861 ttttatatct gccagacacc cacagacaat taatgtacat aaaattaggc gcattgatag 1987921 gcacccatgc ctcattcgca ggtaggtatt caataaagac ttttgcccgt tcatgtaagc 1987981 gatagaacac caatccttca tccattcgag ctttgagcca tctcttcttt tcattaactg 1988041 catgctcata ttgtttcgtg cttaatgcac agcaaatatg attgtcttca atattgtcct 1988101 ttgtgatttc aatgtagcac atctcctctt tccccccttt aacataatta catggaattc 1988161 aacttcacac tttacatgcc taatagaata aatacccgtt ccaacttaaa tactttttct 1988221 tttccatttt gccaattaac tgtaaaaccc ttcttttatt cagatattat cttgattcct 1988281 atatcaccca tttcaaatcc aaagtgtgtt catctttgag gattagatgc actgcttatg 1988341 ctataaatac agtacacgaa gttttttatt tgaagtaata tttgttacgg gacagcaata 1988401 gtaaataagt gataaaaggg gaattaaact tggtggaaaa atgttattct tgtttaattt 1988461 gcggatacaa aggattaatt caaaatcctt tgtataaagg cgagtatcaa aaaacgtttg 1988521 acatttgtcc atgttgcggt tttgaatttg gctacagtga ggatcatgat gtgaggttag 1988581 gttttattgt aactcctgat catttaattg aggctgcatt tcaattgtat cgcaaacaat 1988641 ggcttgagag cgggatggta attgctcatc cggaagatat tccagaagaa ttgaaaaatg 1988701 gcaattgctt aaaatttgaa gttttgttga aacaattgaa aaaactaaat cttgacatag 1988761 aaaattttga aattagcggt ttttaatgat gaaacaggtt gcacttgttt aggtttcact 1988821 gtcattatca gtaaaatgtt aagttgaaat gcgcaatcag tcacaaagtc tctattcgta 1988881 ttcaataaag actttgtgat catcgacaaa catttcactc ccatcggata aagtatccaa 1988941 aaggcctcct ctggttcttc tctatagtca ttaatcacag tcactttgac atttgactca 1989001 gctatgattg gttttccaac aatttttcgt tttttcctca ggcaaagtaa gagatcgaat 1989061 catcaaagcc attccatctt tactgtctaa ttaacgccat cttcagtgaa tttaaaggtc 1989121 tgttttaaat tgcgtccttc ttgccccttc tgtgtccaaa ttataacaac ctctaattca 1989181 gaggccttat ctgccagcat aaaatgattg aacttcagcg gtgagccatc atttaaactt 1989241 tcagctaaca ttttagaatc ttcttttggt ttgacacaat tttcatcggg acatccaaaa 1989301 agcgaaaacc ttgtgattga attagggtca tttctataca attgcacatc cactgtagct 1989361 gctttttccc ctatattttt gacttccaag gaatatactt gatattctcc tttatgaggt 1989421 ctcgtaaatt cctttacatt ttttgcttca cttactttta ctgaccactg gtctgttttt 1989481 tgtgtaatag gcaacaccgt aaaagtcagg gcatgcgctt ttgattggca aaacgtaaat 1989541 ccaactgctg taaaaacaat tacagaaaat aatacccttt tcacttcatt tatccctcct 1989601 tcctttcact ggccgctcct taaagaattg attttgagca atctacaagc tctcttaacc 1989661 aaaaccttac ctgaggtttt gtctttactg ctctgcattt atttctttcg gtatccgaga 1989721 aggagctttg gggatttttc tcaatctgct gttaatcaca tcagaagagt atagcgtaat 1989781 aatcatactt cccccatacc tttttgcccg aattaagatt ggttggttat attggttttg 1989841 aaagcgaaag tcaggacctc cccagcttac cgtcgcatcc cgtccgggcg gtacatatgg 1989901 tacacttcta gtatgagaat agcgctgaac gatctgcagt cctgcacgat ctactgcatt 1989961 aaatagagtt gaggacacct gacaaattcc tcctcctaca ccttcagaca actccccttt 1990021 tacaataatg ggtgcacttt tatatccttt gttccgagtt ctcattccca caacttggtt 1990081 aaacgaaaac gtctcattag ggaaaacaac gtgattgtcg attgcttttg cagaaagaga 1990141 aatattgtgt gaacggcttt tattgcttga gttaaaatac gtcacgtact gaccaagctg 1990201 ctgcgtactg atgtgagcta gcagctcgct gtcaactttc ggataaatgt tcatttccgg 1990261 cacttctatc ttggagggac cttgcccata aaaatacgca taaaactttt ccataaacgc 1990321 ctgttgatac agtttgtagc caaccctgcc cgggacgatg cttccatgat cgttaaggac 1990381 agcatttatc ggctcacggt acactttctg atcaagctgt ttgatgaatt tactgtattt 1990441 ttcatagtca accattggag tgccgggaag aggcattgta aagtcttcac ggttaacagt 1990501 ggcaatcgtc cgtccttgct gtgtgaccgt taaactgtcc tgcggctcac tcggctgagc 1990561 caataaaaaa agaccagtga tcaaaatttg tatcataagt cggtttacct cccaatcatt 1990621 agtatgaaca gccgcttatc ctttgatgta tttcttccca tcgtttgttt gaatctttag 1990681 acgttgataa aaaccttcat aaaagagctt agctttatgt tcacaccgat ccctgagctc 1990741 actgaggcac acggttcatt cagtcggcaa gtttgaagta gttcagcatc tcccagtgat 1990801 gagggatgct tttttgtctt gtcaaaaatg aaaagggtct cctataacaa caaaaaatca 1990861 atccatttca atattttttt attgagaaac gataaatttt ttgttacatt caattagaca 1990921 acaaataaat gaggtgcttg ttatgaatcg aatgtcgaca atttttttaa agatagcttt 1990981 ggttcttatt ggaattccaa ttcttgcttt atgcattttt ttagtgccta aggtagccaa 1991041 ctattcagca gaattatttc caaatatcgc ttatataaaa tatctcgttt tcatctattt 1991101 gtatgtaacg gcgatacctt tttactttgc tctttatcaa gcgttcaaac ttttaagcta 1991161 tattgacaaa aacaaagctt tctcgggttt gtctgtaaga gctttgaaga atataaaata 1991221 ttgcgcagtc actatcagta tcttttacgc agcaggcatg cctgtctttt atctgatggc 1991281 cgagatagac gacgccccgg gtatcattgt gatcggattg gttattattt ttgcttcaat 1991341 ggtgattgcg gtctttgctg ctgttcttca aaaactgtta aaagaagcga ttgatataaa 1991401 atcagaaaat gacttaacgg tctgaggtga tgacatggcg attattatca acattgatgt 1991461 gatgcttgct aagaggaaaa tgagcgtaac agagctttca gagagagttg gcatcaccat 1991521 ggctaatctt tcgatattaa aaaacggaaa agcaaaggct attcgattat caactttaga 1991581 agcgatttgc aaggctttag aatgtcagcc cggggatata ttggaatacc gaagtgatga 1991641 agacacagga ttcgtaaaga aaaaatatga aggatcaaca gaaaaataaa gtgattggcg 1991701 gtgagcttat ggacataaac ttatatccat ctagctgcta tactaagcgt ccctttcata 1991761 cacgaagaac acaactatgg aggaggcata catcatgaga gccataaaac aaatcgtcca 1991821 ttttggctgg gaacaagccc tttcatgttt gtttcctgcc gttatttttg cctctttggc 1991881 tattacgcaa atcatcccac tgcccttctt gccgcggtat gactggctgc tcattatctg 1991941 cgttctcatg caattgtgga tggtgcgttc cggtcttgag acacgggatg aattaaaagt 1992001 gatcacatta ttccacctta ttgggcttgc tctggaactt tttaaagtcc atatgggctc 1992061 ctggtcttat ccagaagaag gatactccaa aatatttgga gtacctttgt atagcggctt 1992121 tatgtacgca agtgtagcca gttatttgtg ccaggcatgg agaaggctta aggttgaact 1992181 ggttaagtgg ccgtcttttt ttgcagttgt tccgcttgcc gcagcgattt atttgaattt 1992241 tttcacccac catttttcta tagacattcg atggtggtta tcagggcttg tcatcattgt 1992301 cttttggcaa acatgggtta catacgaggt gaatggagct cgttaccgta tgccgctcgc 1992361 actttctttt atactcatcg gattttttat atggatagcg gaaaatatcg ctacgttttt 1992421 tggagcttgg aaatatccaa accaaatcga tacatggagt ctcgtacacc ttggaaaggt 1992481 aagttcatgg ctcttgctag tgattgttag ctttcttata gtagcatcat taaaacaagt 1992541 taaggagcag agtcccacaa aggcagagat ggatgaatct ttttcttagc atacgcatac 1992601 aagctcccaa atagagtgaa aagcaacgtt caaatggttg cttttttctt ttatgtaact 1992661 ctgccggtga gtattcatct tcttcaaatt tcatcgcaac acgataactg attcagatta 1992721 caactgcttt caacactttg acaaactcat gcgccgccgg cgttatctct tcaaatgaat 1992781 gtgcgatgac gccaatatcg cgtgtgaccc taggaaagat gtccttttta atcaattgat 1992841 gcgggacgga tgaaagtgta aagtttgaaa tgatgccgat acccaagtta tttttgacca 1992901 tattaatcaa ggtttcggca ttttgcacag ttaagttttc ctttaattcg atgttgtatt 1992961 gcgaaaatgc gtttgacatc gcgatttcat gaccgccttt acaaaaaatg aggtcatctt 1993021 gatatgtttc aaggtcgaca tgcttttcaa gttttaattc gtcacgctgc ggcgggatga 1993081 cggccaccat atagtcgtta cacaatagct gattttcaaa cggttcaaat ggagatgctg 1993141 cgatcccgat atcaaccgtc cgatcttcaa cccatccttt tatttggtca gaggttcctt 1993201 cgatcaattc tatgcggatc agcgggtagt ttgatctgaa tgccgcaatc gcctgtggca 1993261 tgatatttgt tgaaactgca ggaaatgaac caattttcac cttcccgttt aacagcttgt 1993321 tttcccggtt ggctacttga tatattttgc tttcaattcc cttcatttgc ctcgccagca 1993381 gcaatatttc ttttccgatg tcagtcagca ttaaaccatg atgtttatcc ctgatcaata 1993441 atttgagctg cagtgagctc tccaggtttt ttatcgcttt acttaccgcc ggctgagaga 1993501 tgaacaattc ttttgccgct tctgtaatat ttaatttctc cccaactttt acaaatatgt 1993561 gaagatggtt catgttcata accatttggt tataccccca ataataaaaa tgtatttcag 1993621 ttatacataa atgtaacata tgatagaaac cagcacgata ttttaacaag aaaggcggct 1993681 tcattatggt aaaagttatg ctgggaatca tatctgtcac acttatttgg ggttatactt 1993741 gggttgcgat gaaagtagga attcatgaca tccccccgct tttattttcg ggtttgcgcc 1993801 tgttcatcgg agcagttcct ttatttctca ttctcttcat ccaaagaaaa aagctttcaa 1993861 ttcaaaaaga acatctcaaa agctatatca tcatgagcct gttgatgggg ctgggctata 1993921 tggggatttt gacgtatgga atgcagtttg tcgattcagg gaaaacctct gttttggtat 1993981 atacaatgcc tatatttgtt acggtgatca gccatttttc attaaacgag aaaatgaatg 1994041 tgtataaaac gatgggactg gtctgcggcc tcttcggact gttatttata tttggaaagg 1994101 aaatgctcaa tatcgatcaa agcgctttat ttggggagct gtgcgtactt gtggcagcgc 1994161 ttagctgggg aatcgcgaat gtgttcagca agctacaatt caagcatatc gatattattc 1994221 acatgaatgc ctggcacctt atgatgggag ccgtcatgtt attggtgttt tcctttatat 1994281 ttgaggcggt cccttcagcc gagtggacat atcaggcggt gtggtcattg ctgtttaatg 1994341 gcttgctttc caccggcttt acctttgtcg tatggttttg ggtgctcaat caaatccaag 1994401 cgtcaaaagc atccatggca ttaatgtttg ttcccgtatt ggccctattc tttggatggc 1994461 tgcaattgca cgaacagatc accatcaata ttatcctcgg cgcactgctg atatgctgcg 1994521 ggatttttat gaatacattt acattttcac gacggaaagt gtgaatgata tacatttccc 1994581 ctgtcatttg ggcttcatgt gacaggagaa gactattacg agaaagtctt ctagaatcct 1994641 gacgacagcc tattaaacaa tgaaaaaagc taatgtctgc atgtagacat tagcttggct 1994701 ggcgtttagg ctggtgagaa tccagatact tttttattac cattctggct gatcaaactg 1994761 aaaaccgtat agacctttta ctttaacatc tccgcaatct ggatcttttg tcaaaatcaa 1994821 ataatgagtc ttataaggca tcgtctcaac tcgatcagtt gcactaaaat caaaatgatc 1994881 ccccgagaag tttttttcac taacggttat ttcatatcct gacaaagtca ttcgcatgat 1994941 tcttgcgtta attgtacatc cttcagtatc gaaaatggtg aatctgtacc caaagtgaga 1995001 tgtccaatgg tttgaattta ggtcatcaga cttcataaac catttttcat tctctgtcat 1995061 tgtaaaactc actttctcct catctttcac gataacggcc gaagcttccc ctacatggat 1995121 agtcaaagcc aaaagaaatg taaaagctaa catcaacatc tttttcaaaa gagttcctcc 1995181 cgatatcttt tacttcaata tattggaagg gtcttttctg atcaagacag tcttctccaa 1995241 atgaatcttt agcaccatga aatgagcctt aataagaaca gttttaaccc aaatcaacct 1995301 ctattcgaaa taaggcttac caatctatat tctttttaaa agtttctgca tttctttatt 1995361 tagctcctag acacatataa aaaatgctcc tataagttca ggagcactac aaaaaactgc 1995421 taaagtgttt tctatcgatt tattgtattc attagctcaa agaaatattc aggcttttga 1995481 gtcttattta gcttatacca tgaacgcaat gtatctggtg caaatacatc taattttttc 1995541 aatacttcta ccgcaaattc cagaggagca attcctgatg cagtaaccaa attttcatca 1995601 gatactgcag gccccttttc atagaatgtt tctcctttgt aattagggca gaccatattc 1995661 atatagtcga ggtcattgct tgtgtgcttt ctcgaattta agtatccttc attcgcgagg 1995721 cccaaggttg ccccacaaat tgcagcaata gtcgtgccga gctttaaagc gtcgccaact 1995781 tttttcaaga tcggctgatg aatatcttct ccccaagtgt ttcctccggg taaaatgata 1995841 agatcttgac tcccaagagt acattcgtca agagaaatat ctggttttat gcttaatcct 1995901 cccaacgtag ttatcatttc tttattaacc cctactgtaa ctacttttaa agatgctgca 1995961 tcttgtttaa agtatctccc tgagtttagt tccgcaatta aatatccata ttcccagtct 1996021 gacattgtgt gaaatacgta gagataaact tttctcgttt gcatccaata acactccaat 1996081 cacaattgat aaagctttct aatagatgac tttgctgaca gtcattgtca gcttttttgt 1996141 tgattctatt cttatgccct tgttctccca acttataaaa atataagatc aattgattct 1996201 atgtttacta gcgcaaaggg gtttgttaca ctaactgtca tgggaaacat ttcaaaggta 1996261 atacaaaatc atttgaatga ggaggcctga tgaagttgaa aactaaagcg tcaataaaat 1996321 tcggaatatg tgttgggctt ttatgtttaa gcattactgg tttcacacct tttttcaact 1996381 caacacatgc cgaagcaaaa tccatagaag acacaaacat ggcaagctgt ataacgaata 1996441 aaaaatttgt tcaacttgag aaaaaatttg atgccaggct tggtgtttat gcaattgata 1996501 taggttcaaa caagacaatc gcctatcggc cgaatgaacg atttgcttac gcatcaacct 1996561 ataaagttct agccgcagct gctgtcctga agaaaaactc aattgaaaaa cttaatgaag 1996621 tcatccacta cagcaaggac gatcttgtta catattctcc aatcacagag aaacacctag 1996681 atacaggcat gagcctaaaa gaaatctcgg aagcggctat ccgttacagc gataataccg 1996741 ctgggaacat cttgttgcaa cagcttggcg gccctaaagg ttttgaaaag tcactgaaac 1996801 agattgggga tcatgtaacg aaagctaaac gattcgagac ggatctaaac tctgcgattc 1996861 ctggtgatat tcgtgacacc agcaccgcaa aagcactggc aaccgatctt aaagccttca 1996921 ctttagataa cactctcacg actgacaaac gcatgatctt aaccgattgg atgcgaggca 1996981 atgctactgg tgacgaactg attcgggcag gcgctccaat aggatgggaa gtcggcgata 1997041 aatccggagc cggaagttac gggacacgaa acgacattgc tatcgtttgg ccgccaaaca 1997101 gagctcctat tgttgtggca attctgtcaa accgctttac gaaagatgct aattatgata 1997161 atgctcttat cgctgaggct gcaaaagtcg tccttaacga tctcaaataa tatgtttagc 1997221 cttttgccac aaaggaaaag acattacttt tttaacttct accgttcatt ttttgatgaa 1997281 cggttctttc ataagacctc tagaatcata tatttaaaca ccacaaaatt aaacattatt 1997341 ataattaaca gcaagttttc attttatgga acaagtaaag tttgaatctg acaagaatta 1997401 agactaagca ccctaaaatc cgttttcttt tcttccaaga atatactcct tagtgcaagc 1997461 cattataaag atacaagtga acatacaatg cagacaactc tcttaagtct cttattctgt 1997521 gaccaatttg taatactcat gaatatccgg actcacttcc aatatttcgt ctcgttcgaa 1997581 gacactaaca tatcaaacca cttgaattaa cataactgaa cttgatattg gtcactggca 1997641 gtttcaatgc aatagaacaa catttgttgt ctcagaggtt atctatatga gaattcaaca 1997701 atttttttat aataattcat atttttgtat cgttgcactt ggtggatttg actcttttcg 1997761 tgtatggaac cacactttta ttttttcacc tcttttgaga tcatctgtgt tatcaatctc 1997821 acttaatcct acaattacta tgttattttt aaacttgttc ataagttgtc cttcagaaag 1997881 attgtaatct tcttttcctg gagcttttgt atcggtaatg agaattgccc tttcattgtc 1997941 tttaagcacg acatagccta ctaggctctg catctttgtt tcgtctccgt tttgttcatt 1998001 tttattgcag cctgcaagga aaataatgag cataatgagc actatcaagc ttactccgat 1998061 tttaggcatc tttcttcctc ctctttaaac tcatctttaa aataaacaac aggatatcac 1998121 ccaacccatc tacttctttt tgcaattcat aacagcagca tactcattct ccaattcctc 1998181 aaccttcttt ttattctttc tcaaatattt gcatgtggta gccctcgata ttatccgctt 1998241 actcattttt gcgctttcaa atatattatt gaaggccgct tctttctgga ttccagcata 1998301 aatatactta tccttactgt cgtttactat cgcaacttcc attaaaatcg agatttttac 1998361 tttttttatg atccattatt cacttccaaa ataacttcca attacaacat aatatatgta 1998421 taaattgtaa atggagttga tgtaattgaa gattaggaaa atcttattga gttctgcttt 1998481 atcctttggc atgctaatat ccgcggttcc cgcattggct gctggcactt cgtctgaggt 1998541 tgcagtaaaa aatgaagaat atgattatga cactatatac cgcattagtc ctctgccaat 1998601 ggacttccag ccaacaatag aatacaacgg ttatacttat acgcttacac gtcattattt 1998661 tgattactca atcgggtttt acacggctat ttatacaaaa gttgtttaaa cttataaagg 1998721 agctttttag ctcctttttc tcttgtttta agcaaggtat ttctttctat gtggtcccct 1998781 atcaaataca acatcaacat tctccagttc tctttgacac gaacaaaatc taaagtttgg 1998841 ttttaaatgc tggtaataaa aaattcactt taaagaagtg ccgcccgcaa aatacggctt 1998901 ttgtacacta cgccaatttt atattgaaaa gccagacctc ctcaaagagg ttccagcttt 1998961 tcttaatgtg ctatcgatct tcgttagttc aacgggaact ttatcattcg gtacaaatgc 1999021 agcctcccaa cttctagtta gggctgatgg cggaatatct gacggttctc tacacacatc 1999081 agacattaga agatttcaat gtagccttct gtaccatgaa cgcgaattcg ttgcccatct 1999141 tttatcagct tggcagcatt ttcaacgcca acaactgcag gtaagccata ttcacgggct 1999201 ataacagctc catgggtcat cagcccccca acttcggtga ctaggccttt tatggataca 1999261 aacaatggtg tccagcttgg atcggtaaag gaggtaacta atatatctcc atcttctaaa 1999321 tccgcatctt ccatgtttaa aatgacacgc gctcgcccct ctataactcc ggaggaaaca 1999381 ggtagaccta caatcgctcc ggctgggaga ttttctcgtt tatactcacc tgtaacgatt 1999441 tcaccatcag acgtgataac acgtggtgga gatagttttt catataatgt gtactcgtct 1999501 tttcgtgtac tgatgatttg ataatccagt ttatgtgtgc gcacgacttc gtgaagttct 1999561 tcaaaagtga gatagtatat atcttctttt tcatgaataa cgcccgcttc tatgagttgt 1999621 tcggcttctt tcagtaaagc ctgcttataa acgaagtatc gattaaccat gccgtatttt 1999681 ggatattccc taaacccgct gaaattccgg atgatatcta tcgctcgttt tgtttctttg 1999741 gctttttgtt caccatccgg taattgcttc aatcgatcta ataactcttg ttctttcttc 1999801 aaagcttcct gtcgcccttg ctcaaatttc cgatggccga cattaggctc aaaattttta 1999861 atattattaa gaatcattgg gacaagtgta gttggttttt cgctccatcg agttcttgtg 1999921 atatcaatct ctccggtaca tcgcattccg tatttgctga gataatcata gatcgcgtct 1999981 cgggttttgc ttccgccatc aaacttagcc agttcatcca aaaagttatc atcttttaca 2000041 tgttgtaagt aatcaattac ctctggataa ggacgaatca catctgcgac gtctaatagc 2000101 gcaagaccca tttctgaagt aatattatgg ggtacagatt gagaaagcgt atctgctgcg 2000161 tttttttcac ctaaccactc gttcattttt tcgttaatcc ataatgaagc attcatagca 2000221 gttcgaatta gaaccgaact ttttgggtta aataaaatct tctttaattc ctgaatatct 2000281 tccagaataa aacgaaataa atctgatcct gatttcgttt ggatgttttg ttttaactct 2000341 tctatcgatg tttgactgct ctcaatcaaa tcagacacga ttgtcggatc gttttcaact 2000401 tgagccggca tatctgcatt gcctctgctg ggatttggtg ctgttttatc atttggtatc 2000461 gactttatga aatctcgtcg ctttattatg gtcataagtg cgtcttttaa gagctgatcg 2000521 tgctgcccca tgccttttaa gaaaacttct ctgctgtcag gggatgccag atgatgtgtg 2000581 acatcaacaa atagccttcc accggcttta cgcatgggtg caacagtcgt caacagaaaa 2000641 aaagacaatc ccagtggttt tatgggatcc gtcatcattt gttgatgacc aacagaaata 2000701 tagacgtgat tttcttggtc actcgcttca gggatgggga ataaagtagt gattggacga 2000761 ctctgtacaa tataaaaagt atcgcgggcc aaacaccatt cgatatcttg cggctggccg 2000821 aaatgagctt cgatctgtct tccaatgcgt gccagctgta aaatttgttc atcagtcagt 2000881 gtttgagcct tttgctgatc agaatcgatc tgctgtgttt ctgttccgcc ttcttttcgt 2000941 ccgtagatag ccattttttt agttgctatt ctcttatcga tgatttgccc atcctgtact 2001001 ttaaaacaat cggcagatac caagccagaa accagtgctt caccaagtcc aaaaccggca 2001061 tcgatggata acacctttcg gttggaggta atcggatcag cggtaaataa aatccccgaa 2001121 gcctgaggga aaaccatcct ttgaacgata acggataaat agacttggct gtggtcaaat 2001181 ccattttgca tacggtaaat aaccgcgcga tccgtaaata gggacgccca gcatttactg 2001241 atatgctgca agattgcatc gacgccggta atatttaaat aggtgtcttg ttgaccggca 2001301 aaagaagcat gtggtaaatc ctcagcagtc gcactagaac gcacggcata ggcatgttcc 2001361 tcgccaaact gggagagata ttgagccact gctttcacaa catcggaagg aatgtctact 2001421 tccataatga tttgccgaat cttccggctg atgttaccaa tctgatctcg gtcctcaact 2001481 tttagcatgg tcaattgatc caacaacact tgtaacgttt cgttttgttc gatggctttt 2001541 tgatatccta ctgttgtgac acaaaatcct tctggtactt gtataccttg aatttttgat 2001601 aattccccta aatgtaaccc ttttcctcca acgagcgaaa gctgtgtttt ttcaatttca 2001661 tgtaaaccga gaaccaaaga actcattcta catctcccct tcaaaaaaaa atattgacaa 2001721 gagcttccta gcaggatata ataaaattat aagatggata tctataactt tttaactaga 2001781 aagcgcacgt agtgtgatta tatcaccgtg tctgtttttg tgcaatataa aaagaacctg 2001841 ggaaatttca ccaggttctt ttcttaattt ccatagctag tcgcattaaa aaacttggtt 2001901 tgagctgatt caatcctcta aggaaatcct aaagttgggt tctttttgaa cttacttgct 2001961 ttgttcgtag agtccccatt cataaattgg actttttgtt cttaacagtc ccacctttaa 2002021 ctagtataaa gttatgagga tctggttaac tactagatat ttttattttg aataaggctt 2002081 atgtttgata aagaagggtt atgtaaaggt gtctgttgtg agcaagcgct gactacaaaa 2002141 aattgatagc attctcattt aaataccatt ctattaacct atagggaaag ttttaaaacc 2002201 agatggagaa taccctacct ccagcaattc caaggccgtt cacctagtag aaaacaacct 2002261 ttaaccatta ctaacgattt taataatcat tgattataaa acttctcaag gaacgatcag 2002321 cagcccgtta gctacccctg attaaggatg atctgttacc acactgttac gttagaactt 2002381 ccactacttt gatatccttc tgtcgccatg acttggtaag cccaattact gcccagattc 2002441 attccatggc tcttccatgc gttcacatga ttgctgaaag tgattgtagc gttgcttccg 2002501 gttggtctct tcgactggcg aacactccag tactgcgtaa aagtagtgcg atcgccatca 2002561 atggaaggtg cgttataacg tgtagttgta tatatgtcat atgtaccccc atcacttttt 2002621 acagtacctt tatacgttcc agtaggtcta taagtacccc atgaatccac tacataatat 2002681 tctatgagag gtgatctcgt ccaaccatat aaagttaaat atccattgcc attcggcgcc 2002741 caaactccgg cattatagtt tatcgtccta aatggcgaac ctgtagtcca acctttacca 2002801 acaacaaaat ttccggtatt agaccaatta acactgtaat tcccgccaga cccattgaca 2002861 gcgtttacta taccgccccc atcagtccaa ttttgccagt agtctgtgct agctgcagag 2002921 gcggttgccg aaaacaagct aatactcatt aaagctgccg ataatccaac taagaaattc 2002981 tttttaaact taaacatatg ttacctccta taatattttt tccgactttg aggtagcact 2003041 cgtatacatt taaaacattc ttaattacta acgccaaagc ttttgatcgt ccccttcagt 2003101 ataataccac gaattcatga gcaaatatta aaagtatttg taattcaatt acaaatacct 2003161 agaaacacat tataagtggt cttcttccac catatcctga tccttttttc gcaggatcac 2003221 aattcttgtt tctaattcag atggagtaat atctgcaatg aattcccatt gaaccatttc 2003281 aaataaagga gatatacatt agagattgtg aaattattgt agctgccgct tgtctaatga 2003341 agggaagcaa atttatgaag aatatgaaga actgaagaag aaaacaatta aggttatact 2003401 aagaaagaac tgctcaatta aaattattga ccaaatttga ggatgatagc ttagatcagt 2003461 tttacaaaga agttgcaaga tttttatttg aaagggctct gaaaaagaaa aaaaagaatt 2003521 gacaatcagg gtaactgtgg gatgtaaccg agcctccaat tcaaaataaa tatctttaac 2003581 tttctttttt tatttaaaga gggactgtat atccctcttt aaaattaagc tttagattgc 2003641 tgctgaaagt aataaaaatt gtacttttga tcaaaccctt cttcgctacc acaaagaaaa 2003701 ataatgaatt caataaatgc gataatagag gggataccag tccagcaaaa caaaatatat 2003761 agaatacctt gtcctactct tcccaaataa aacttatgta ttcccagacc cccgaagaaa 2003821 aatgctaata atgccgctac aattttgttc ttcttgctta ccatgacttc ctcctagttc 2003881 attgctacca tttttaaagt aatgctttca cattataatg cattttccgc cagaaatcgt 2003941 gaaaattttg aaattctttt gagatttttt attttattga gaaatgaaag ctcatataat 2004001 tgaactagat ggttttggga ggcatttatt caaaatgtat tgccaaagat tacggcaatt 2004061 acgaaaggca cacaaattaa caatggaaca gttagctgag aaaattggaa ttgcaaaatc 2004121 aagttacggc gggtatgaag ctgaaagcaa aaaaccacca ttggacaagt tggttatttt 2004181 agctagacta tatgatgttt cagttgatta catacttgga ttaacagatg atcctgatcc 2004241 taaagtggaa agaaaaaatc taaaagagtt tttagaaaaa ccagatattc actgggatgg 2004301 atataaactt acccctgaga tattagatcc tatacggaaa attttgaagt tggttactgc 2004361 aaacaacaat taaaaaagcc ctcataaggg cttttgcata aaacaattat ttcattgaat 2004421 tttctggact catttcaaga agtttattca tgatgatagc taaactttca ccagcttttt 2004481 gtagcttctc acctgctttt atcagagtaa ttaaagcact taaaaagtcc actaagctat 2004541 tttgatttat tgcaactgtt tctttataag ctttgtaagc ttcttcaaac tgatcaaatt 2004601 gcacaccttt catagcaaca acagctaatt tatctgaaat atttccatat gactctgtta 2004661 aactaaaaaa tcttttgaca ttgattagta aggcaatgca ctttaaataa tcgtgcccca 2004721 gaccaatatg taaattgcct gcagcaaaca gcaaatcgtt caaaactgtg tacggttcac 2004781 cattccttgc aactgtctca atccctttgt ataagtataa taaaaagaca aatgaatttt 2004841 tatctgtgga acgctcaggt aataaggaca ctataataac ttactttaag ccaaaacatc 2004901 caaataaaaa ggctggttat aattattata aaaatcaata ggaactataa atatataaag 2004961 agggattgct atgccaaaat tatatacatg tttaatttgc ggatataaag gattaattca 2005021 aaacccatta aacaatgatg gtgagtatca aaaaacattt gatatctgcc cttgctgtga 2005081 ttttgaatac ggctacagtg aagatcatga cgtaagctta ggttttattg taactccaga 2005141 ttatttaatt gacgctgcaa ttcagttata ccgaaaacag tggattgaga atggaatgaa 2005201 aactgcaaat cctgaagata ttccagaaga attaagaaac ggtgactgct taaaattcga 2005261 ggtgttgtta aagcaattga atagcctaaa tctcgatact gaaaactttg aaatcaaggg 2005321 atttaatggt tattaagcag atccaagccc ccatatgggg gcgttcttat tattgtacag 2005381 tctatcagaa ctatttatag aaaaactatt taatgtattg tataaatatc actgaccttt 2005441 tctttctcca ttcaacttcc ttaaccctca actgtttgct gctgcatcac attcctcctt 2005501 tttgattttt gtgtatcaag cctgtacaat attcaaaaac cctaaaggat gatgaacatg 2005561 tgtggcaagt tcactttatt ttctgagttt gatgacatca ttgagcaatt caacatagat 2005621 caattcttac ctgaaggtga atatcaccct agctataatg tcgctccttc acaaaacatc 2005681 ctgacaatta tcaacgatgg atctaataac cgtctgggta aacttagatg gggtcttatc 2005741 cctccttgtg ctaaagacga aaagatcggt tataaaatga ttaatgctcg tgctgaaaca 2005801 ttggccgaga aacccagctt tcgaaagccg ctcggaagca aacgttgtat cataccggct 2005861 gacagttttt atgaatggaa acgccttgat ccaaagacta agattcctat gcggattaaa 2005921 cttaaatcgt cgaatctctt tgcttttgcc ggcttatatg aaaagtggaa cacgctagaa 2005981 ggcaatctgt tgtacacttg cacaatcatc acaataaagc ctagtgagct tatggaagac 2006041 attcatgatc ggatgccagt tatcctaact gatgagaaca aaaaggaatg gctaaatcct 2006101 aaaaatactg atcctgatta tctacaaagc ttgttgctgc cttatgatgc tgatgacatg 2006161 gaagcatatc aggtatcttc attagtgaat tcacctgagc tcattgaatc ccattaagta 2006221 ccactgccat atcgctttat ataccacctc ctcttagcta atatgttcta agtaggaggt 2006281 ggtattttgt ttgtatctcc aatgctattg cattcaataa aagagccttt tgatgacgag 2006341 agctatatca ctgagcttaa attatcaaga ctaaaattaa aataagggct catacatagt 2006401 tgatatatat aatatgtatt gagaccttta ttgaacaaac gccccgtttg ttaaagtgga 2006461 aatctctata attaatagcc gacttttaaa agttccaatc taaaattatc ctctaaatcg 2006521 gctagcttca ttaacttctc cgatatacct ttccaatctt tatttacaga catagaatga 2006581 catatcccaa acaccttagc ctgttcagtc ttcaacactg ataaatgtga atgcctatct 2006641 ttaaaataca ttgcataatc gttggccctt cttgcactta attggaaaag gaagaatgtt 2006701 gtatgcctta tagtatcagc tgtaataggg gcatttaata attgatcagc ataaaaacaa 2006761 attgcttccc ttccaattaa ccctatatcc actttttcga atttccgata agttctctta 2006821 aaataatcaa ttgctctctc gtatatttcg ttattgtcta atgtgacaac cttttttgct 2006881 gtagaccaat atttattgat tcctttccta tacggaatcc tttccgccat ccaagccttc 2006941 ttaaattggt ccagtgataa tggaacaaat ggaaagcctg ctggatcttg cacataaata 2007001 ttttcattat ccatttggta ccctagaaca taatggtcag aaccatttaa atttttatga 2007061 ttcggatggt atgttagctc ccccatatct aaagggccta gaatgacagg gttttgtttg 2007121 atttgctgtt ttaataacgg aaatgggtca tctaagtcac tagcttgctg atgttcttct 2007181 gcagtaaatc caaggatgtt taaagcataa ttgataccat catcaggatc tctcatacta 2007241 aaataaaggt ttttttcata ttctatcatg gcacctaacc caacaccagt taatatctct 2007301 acaagttgag gagatacatt ttctcctatt gatgaaagaa acattgcagt tgaatttgaa 2007361 taacagtaat ggccatttcc tatatacact aacatcacct ccgggtagat aagttaacct 2007421 tacaattttg aaaattgaaa atccatatta aattgctccg ttctcgtatt catcatctgg 2007481 atcattttta tcaacaataa tgatcttctc gccaatctcc gttttacgat cgacctctac 2007541 gtattcgcgc ttgatgctgc taagtgtttc gtcagccagt acgtgaatca ttacagttga 2007601 gttcgcttta atttccgtca tttactgcac cctttatatt ttttttatgt tttttcaatt 2007661 ctttttagat tttcatattg gatttcactc ttttaattat agaggcgtgt catacacatg 2007721 ccatctaaga gagataggac aattttgtct tggaggtgaa agctaatgaa ttttcttctt 2007781 gatcttttta caaattggac ttttgataaa gtcctggatt atacactagc tgctgtaatt 2007841 tggtctgtat ttaaatccag atcaaagcag aataagtatc caggctattt cgagaaaata 2007901 cgccgctata gaaatttaca tccccttctg cgatcgttat cgatgcgtgt acttttatcg 2007961 ataacgatcc atccttatat gtttagttaa aaactatctt ttatttagac ttaatgggat 2008021 aaaatcttca ttgtaaaact cttcccactc agcaattaag tttctataat agttttggtt 2008081 agagtcggtt ggcatagatt caatattgtc aaaaccatta ataccgacat ctaattctac 2008141 tgtcactaat ccttggtaaa acttcttata attcttttta attactttga aaaattcaac 2008201 atcaaagaag tcttcatatt cagttgctcc actccaagaa tcataagagg acttaacacg 2008261 ataattaaaa agaaccaaaa ctaactcatc tttcacatct tttgatattt gctccattaa 2008321 ttgatttagt ccttcactgg cattaaaatc tacaatgctt aatcggaagt caatccaagt 2008381 aacagcttca tcttttaacc ttccttctcc gtcttcattc acttcaatta atacatatct 2008441 gtcagccata attccctcct aatttatttg tttaaaatca cgattttaac tatttatgat 2008501 ccattagtca cttccaaagc aacttccatt taactcataa ttaatatata aaatgtaaat 2008561 ggagttgata tatttgaacc ttcgaaaaat tttattgagt tctgctttat cattaggtat 2008621 gctggtatct gctgctcctg tcttggcaac aagttcttcg tctgaagtga tagtaaaaag 2008681 tgatgaatat gattatgaca ccatatatca gcttagcccc ctaccaaact tcaagccttc 2008741 tattgaatac aatggatata cttatactct cacacgttat tatttcgatt actcaattca 2008801 gttttatacg gctatttata caaaagttgt ttaaacttat agggagcttt tttagctcct 2008861 ttttcacctt tttaagcaag atatttcttt ctatgcggtc ttttatgtat gaaatcaaat 2008921 gctttcccta attccttctc ttctgttacc gctgagtcca tatcttatat tgcatctaag 2008981 gtttagtcag tcgagatcat tgaatatata gtactttact cagaacattt tgcttattaa 2009041 ggacataata agtgttcgta ttaatttttc ctgttacgat aacgatcaaa aacaaaataa 2009101 tttatctcat tttaagacag aagttattct gctttttcaa aaaaatattc ttgattttcc 2009161 cttttttaga tgcatccata aagcattcga tcataaccat tatatgtaac tgaaatgcag 2009221 gtataagagt tattatatag ggattacact accattatct gggggtgtat taacatccaa 2009281 atactcaaaa gcaagaacaa atgtacccat agcacttcca tttccacacc ctatccaaat 2009341 tttcattttc ctaattccac atcaaaatca ccctttttca catcgtaatc actatcgtaa 2009401 aagcctatag tatcaacgtt tttccttctt aaaattttct ttttttataa atatcttccc 2009461 aaaacaacca ctttccccta ctcccgctta tgttttacga tcgtttaccc cctatttact 2009521 aattaaagta tcaaaaattc ttatgtttac tgtcttttta gctcattata aatttttacg 2009581 ataagcaatt gcctttgctt ttggatatga cttgactgta tttggtgacg atttaacaga 2009641 gaaatttaat gctcttctga cttttttaac tgcattgggc attattgttg atccaacaac 2009701 tcaaggtatt tctgatagtg aacaagcaat ggattatgat tcaccgagat aaaccccata 2009761 cccttctctt gattgaggag ggtatttttt tcgttttttc aaatgaaaaa attgcagaaa 2009821 actttacatc cttttacaat tttttcaatg actatgttat gattgttttc gagagatttt 2009881 tgaaattttc agaaagaggg gtttaaatga gtaagatcgc ttctgaagtt gtcgctacta 2009941 cactgaatga ctggtacatt gctataaaaa aacaaaaggt tgatgaatca ataaaatatt 2010001 attcagagat aaagaaactt tttgatgaaa tggaagaaga tcaagaagtt cttgcgtatt 2010061 atagtctatt agaagaaaga cataaaatgt tgctgcattc ttcacgagga gagcctttac 2010121 aaaagcacac ctattttact gaagacaatc aaaacttcat aacaaaaaca aatgataaat 2010181 tagaatacaa cttttattta tttgaagcaa tgtacgaggc atacaacaaa aactatgatc 2010241 gagcaattaa cctatatgga ttagctgaga aaaagcttgc agaaattcca gatgaaattg 2010301 aagcagctga attttactct aaagtctctt acttatatac tcttgttaaa caaagcattg 2010361 tggcacaaca ttatataaaa aatgcaattt caatatataa gcgacaccct gattataaat 2010421 gcaaactagc tacatcaaca atgattgcag ctgcaaacta tgctgatatg aaacgatttg 2010481 aggaagcaga acaatattac ttagaagcaa ttgatattgc aaaagaaaca aaagatgaat 2010541 ttttaaaagc tcaattattt cacaatctta gtatcgttta ttctgattgg aacaaacctg 2010601 ataaatgcat tgaatctctt gaaaaagcaa taggaaatga atcttggtta cattcgattt 2010661 attatataaa ttctttattc atgatgatta aagaactctt taaaattgac gaaaaaatga 2010721 aagccattaa tttttacaat aaagcacagg aaagactcat attaatggag aataaagtat 2010781 acgaagccaa aatcagcatc ctgtataacc tttattgtgg ggaattaaaa aataatttca 2010841 ataattgtat tagtaatatt gagtttttaa aacagcaaaa tgaacttgaa agtgtagatg 2010901 aattgtccta catagctgca aaaaggtttg aatcaatagg tgcttttgaa gaagcaacga 2010961 gctttttcaa tgcgaaaatt tgggctgaac agaaaatgaa tcaggtggag ggaatcttat 2011021 gaaaaaactt gtgctttgcg tatctatttt agctgtgatt ttaagtggag tagctttaac 2011081 gcaattgagt acagattcac catctaacat ccaggtagct gaaaggccag tcggaggtta 2011141 aaaaaggttg attaattaat ttagccctac tcaaacattt gagtgggctt ttattttatg 2011201 atttatgtcc accggtcagc cctgctctgt ggagcgcagt acctgcaaac gtaactgaga 2011261 tacttctcac tgttttttgc ccgagtaaaa cttattaaag aacatcaagc aacacttata 2011321 aatatccatc gtgatatttg tgggaaaatc aattgttttg gatcgatgaa aaccaccgcc 2011381 aagctcatct ttactgtatc caattcctag acttattgtt cgaccaactt tattatatgt 2011441 acgtgccctt cttgcgactt cctcacaaat ctccaagagc acagctttaa tctcttctct 2011501 ctttgtataa tccctaaaca aaatctgact cttaccaaaa ctaatctgcc cctgcatcaa 2011561 tggagctcct atttcagata aatcaattcc gtgagcatga tagtacaact ggtttcccat 2011621 tattccgaac ttcttttcaa gcagctctaa aggaaattta gctaactgac ctacagttga 2011681 tatacccatt cgattcagat ttctttccat cctccctcct atcccccaca ttttagacaa 2011741 aggtcgaact ttccagagtc tatttggcac atcttcatat ctccaacgtg caataccact 2011801 ctttgttttc ttactctcca ggtcaagtgc aagcttacta agcaacatat tgtcaccaat 2011861 tccaactgtg cacatcaaac caaattctct ccacatgctg ctttggattg ctttggccat 2011921 ttcttcagga ttctcttttc ctgcatctaa aaaagattaa tcaattgaat acgtgtggac 2011981 acatttttca ggaacaaatc tgtaaaacag ctttgtaatc tcagttgaaa ctctgatgaa 2012041 aagcttcatt tgtggattta caatgtatat tcttggatct tcaggtatct caaatagtct 2012101 cgatcctgtt ttgattccaa aatctttttt aagtgcagga gatgcagcta acactacact 2012161 tccctgtcta tccgtattcc ctacaacggc aagataacat gttaaaggat taagccccat 2012221 tgctacagcc gatacagaag cataaaagga tttcatatcg acacagagta tattctcacg 2012281 tggaaattgt gagtaatcag tcattgtata taactcttat gatgttattc atgttgatat 2012341 aaactgtatt gtcgttctgg tcttttacgt gaagcttttg ttgttcaaaa ttaatgtaat 2012401 gtactctgcc ggtaacattt tcaacaaatc ccttgttaaa gagtttgaat ttcaactctt 2012461 tattaaattc caatgcctca gaaacgagaa tatccatctc atcaatttgt ttgtcatcta 2012521 aagatggctt ttcaactttt gatccatcaa tcaaatcttg tttaagctgt attaattgtt 2012581 ctagcatcat tgatgtccat tgatagttcc tcgatcccta aacatatcga ctcactcctt 2012641 gattgatcta atatcaacag aacaaacgtt ccttattcaa tatagatcag aacaaaagtt 2012701 cgatgtaaat gttggtaata aaatataaag gtcaataatg atatccgtag tattaataaa 2012761 ggagagattc ttttcgacga gggagagtgt gatggtgaat gaagaagagg ttaattggat 2012821 ttttggtctt agttcctgct ttgattatgt ggggtataac tttaatcgaa tcaaacaaaa 2012881 agacccctgt agaagtttta gaaagtgctt gggatgaatt tgggttattt agttttgaaa 2012941 ttggaataac agatccggca attacaatag gcatggatca aaccaaaagt gaagcaaaac 2013001 tccgtgaata tttaaaagat aatctgtcta gagaagccaa ggaaaaatat aagatttata 2013061 tattcaagga tgatactgat aagctggaga aagagcatca agaatatttg aaagaaaata 2013121 atctcaataa gtaaaacgcc cagcaattaa aactggacgt taaaaaacat tagttattct 2013181 ttattttttt ttagtattca cacgtaatct ctctctatct tctttaaaag aggatatgta 2013241 gtttttagac tctaatgcag tcaccaacgc tttattagtt ctattatttg agatctttat 2013301 tcgtctgcct ttttcagcaa tttcagagta aggttcccct attttagtta aaaattcagt 2013361 aattgattca ttatcaatat gctttatttg tccagctagc aacgataacc tagtatccaa 2013421 tgttgtaggt gattcaagca aaaaggttag tagttcattg gtgattttca ggttatgctc 2013481 attaataaaa taaattgtat ctttaagaat atcattattt ccatctgtca aacagttaga 2013541 atttaaatgt tgtacaaata tttctttgtt aaattgagag agctcgttgc tatctatgag 2013601 ttgctttata tcattggcat caagggaaaa atcaccttgt ttatcaataa actcgtcagg 2013661 gtttctcaaa gcgagttgga tatgaagtgt atcaaaattt aattttaact ctttaaaatt 2013721 ttccggtgtt agagataaca aatcattatc aatcaataat tttgctcttt tttcactaac 2013781 atttccgagc ggaaagtaaa tccaactttg aatactagca attaacactt cgaatgtttc 2013841 gtctgtaata tcccgactat taatgatttc ttctgagata tcttctaaaa tcgcttcgtc 2013901 aaatttatca tcaaacgcct ctatattatt tttagagagc tcttttctat taacaggatt 2013961 gtttaagaaa gctattaaga aatcaggcat ttttttattg tattctacat aagaagtaat 2014021 aacgtttgac cagcatgcaa ccattttatt ttcacggatc acaattggcc ataactcttt 2014081 aatcaattca ccaatatccg agatggcaaa agtttttttc atgatcattg catgctttac 2014141 tctcttatct aaatcctccc gatttaataa ctccagaaaa ctttcctctg gttcctcaat 2014201 ctcctcagta agtaaaactt tttcaacaaa tatatcaata ttgtcattta cgtaattgat 2014261 aacagcctgc tgatcagagt ttttaactgc agcatacgtt atattgggag catcatttaa 2014321 aataactgat aaagttttga tattaatttc gtatagattt cgttgaacaa caaagtcata 2014381 tattgtttca gaatttagca aatgatccaa acttttaaat ttaacttgga gttttaatag 2014441 tagttctttt attttctcct catcagatac taagctgaga agatttaagt acttggataa 2014501 tgtgaaagac atgaccgact ctttattcat tcggataata tcagctatat cagcatatgt 2014561 aagtatatct gacaagtatt cctctttttt ctgttgtgta taattggatc taagttcaat 2014621 aaaactccaa aaatcatccc atttactaga tatcgattgg ataaaggcag ctttatttat 2014681 tgccctttct ttaaaaccat ctatgaatgt aacagattct ttacttccat ttgcaagtcg 2014741 ctcaattatg ctatcataat aattacggta ttcagaatga tccattatat agtttaagag 2014801 atgaaaatta agtacctcta tttgcttaaa ttcagcacca actaatttgc tcattatttt 2014861 accgatatta tccagctcaa agctgtaagg caatgactcg tggtttttaa tactaaatac 2014921 aaatttaata tcggaaagac ttaaactttc tggatagaag taagtgatgt aatggttata 2014981 catttcatca atatatccat gacgtagcag gtaaacaagt aattttttct cgtaaagctt 2015041 atcagaaaat acatcctttg aattcatttt tgtaattaat acttgtaaag attgcgctct 2015101 tatttcttgc ttttctctct ctaattccaa tagttctttc ttgaattttt ggatttcatt 2015161 tttctctata gccttgatgg catcttctct ttcaaagtag ttcggtttcc gaccaaaaac 2015221 agttgcaatt tctttaattg tcgctggacc atttctattt cttaaataac aatagatagt 2015281 atccgcattt tttaacttct caaaaaaccg atctttatta gatgtattgc ctctaaatac 2015341 ctcgccatct atattaatat cataattaga attcaaattt gatatttcta attcgctcaa 2015401 gtatataaaa tttaattcag caattgattt taaagactca acttctatat tcgctaattt 2015461 cctctctaat tgttgtattt tagcattaat taattttatt tgttcctcaa ttataagttg 2015521 ttttttttga aagatttcat ataccaaccc tttgttatat tgtaatttag aaaaatccac 2015581 aggataaata tttttgtaga ttatcattgc taacattttg ttaggatcaa gatcaattgc 2015641 acttagtttt tgttggtata taacaaattc attaaaaata ttctttaata ctctcatgtc 2015701 atcaatgtaa attgttacat cctctaagaa atgagtgttt atcaaatcag aatatggtga 2015761 atgttttatt ttctttttaa gtatgtctcc tgaattagat gcattaataa ttggtattac 2015821 tgggataata aaatcaaaaa attttgtgcg gtctctagtt aacttttcag tgtctgcatc 2015881 tccaaaaata tcatctttta tcgcatatat aaaaacaaca cgtctatcta tttgttctga 2015941 attatttata agttcattta attctcttaa tctttcaaaa atacctatat tattaaagcg 2016001 atctaagtcc tcaaatatta caacattata cttggaggct tcaaaaaaat ataatatttc 2016061 atctaaatat ttatcaaata tagaagagtt ttcttcccct gtattttttt ctaacgttgt 2016121 attagcaatt gtaaccttat tcaattttaa gttggcacgg acaaaatgat aaattctttt 2016181 atatgcgagt agaggatata ctataaagaa cagtgctaat aatatagtca gtcgtatttg 2016241 ttgctgatct tcagtaccga gactccttga aactaacgtc tcagcatata ttcctttaag 2016301 tgcatcaggt ttaaaaaggt agatgccaac tataataaat gcaaaaaaga aaatcaaatt 2016361 tataattatg ctcttagtcc ttatatgctt aattctttta aacctagaaa agggaatggt 2016421 tctatcgtgt acccggtata tcatttgttg caagatgctt ttctctaact tattctccat 2016481 atcatccgta tctgtgttga atgtagctaa ggatatattt aagaaactat attccctgct 2016541 gtattgtttt tgaaaggtat ttaatatgct actttttcca gacccgtagg gaccagttag 2016601 ggcgatattt ttcacttttt tattttctaa cccccaactt agtgctttag aatattttcc 2016661 atcagtgtcg acatcattgc taggagaaag atcttcaaaa aggctttctt ccttaacatt 2016721 aggttctttt agtctaatca gaagtttctc taaccactgc acaaattttt ttttgatttc 2016781 ccccaaaaaa aacaaatcct ttctaaactt tcaggtgtaa tacgaattaa taaaactgga 2016841 gcaaagaact aaataaatga gtatgtagca atgacaaatc atttctcttc catctaatat 2016901 agtcctttat cgccagttga aattcactat taattgtaac atgaaagggc attaaaagtt 2016961 tctgaaaaaa agatgatcaa taaacaacac agcgcccaat tacaggactg tttcatattt 2017021 aaattgaatt tttataagca ttaattgctt catttcgcag cagcatatta tctttgttaa 2017081 ccatgcctaa gttgtaagct tttttgataa tatctaatac ctgagaatct aacgccgaaa 2017141 gattaccgcc tggattaaat cttgatttcc aataatctaa agaattattt aggtcaagtg 2017201 agcttttttt gttctcgggt ttaactactt catttttctc aagtgtttca cagaattcac 2017261 taaaaccaat ggatctactg ggagctgagt tatttccccc gtatccttct gtagccaagc 2017321 tgcaaaatgc taagaatttt ggatcataaa taagatcgct tcagtttaca tttaccactg 2017381 ataatcacaa tcctctcaaa gctttttata attgtagcac cttttccatt tttacacata 2017441 ttaaatatcg acaatcattc aaatgattta ataattgaat acaaaaaaga acctgcattt 2017501 tgcaagttcc tttcacgttg tcaatatatt gtgaattttt aacgacaagg gcatttatgt 2017561 atagtatgat atttcctgta cagtaagttt tgctcactcg agggagtctt gctcatcccc 2017621 taatgaaagg ggtgatgcta tgtcaacatt ccaggcatta atgctaatgc ttgcaatcgg 2017681 gtcgtttata atcgccctat tgacgtatat agaaaaaata gacctccctt gagcctcaga 2017741 acctgaaggg ataggcctac ctagaaccac atcgagcaag ccctttgatg ggcaactttt 2017801 tgtacagagc cggggtgttg gtagcacctc ggtctttttt attttatgca tttctcatta 2017861 aagaaatgca ctgtaatgta ttgtaaaact gattataaca cattttccgt gaaatgcatt 2017921 acaataaacc tcaagagact tggaaagctt ttttattgtt tcttgtaacg ttataatgat 2017981 ctaaaatagc gcacaagcct ttatacatct tcatcatttc ttactcttct agctcgtctt 2018041 tcaacattcc aattcccaat ctttccccag acattcttgt tagtccattt ccctagctta 2018101 gttttatcaa accattcctg aaacaaagat atttcatctt tcctttgcat tgtatctttt 2018161 aaaaggaaat aatgtattat ccaaaagata taaagagctg aacaagaaag tccaaaaata 2018221 agtttattta cctctaacca atttcctaaa acttgttcgc ctaaatattt atcatataga 2018281 aggggtataa aagcaaatgc tgaagcaccg acaaaaaaag ctagagtttc tttaaaccat 2018341 ctaacaaaaa caaaaacagc gcttaaaata taattcgttc taaaaagaac tttataccaa 2018401 ttataattct tgtttagagt aacaaatata cttctatatt ctttattaac tgcttgatct 2018461 aacattctca ttttataaaa taattttttc ctattctcgc tgttcttgtt taaaatatac 2018521 tctctgaaac aatcttctgt attcaaaatt tgatctatca ataagatgtt tctaagtttt 2018581 gatagcttcc cctttttccc actatattct tcgaaaaatt tttctataag gaccatttta 2018641 tggttttcat cttcttcatt ctttatttct tttagggaat aatacatagg ctctaaaatt 2018701 ttttctaatg tttcacctga ttgagagtag aatcgttcta tacttttttg tctttgattg 2018761 aatagcaatg caactatacc cgtaattact gcagtaagaa taccattttg ttgtatccaa 2018821 ttccaaatat ctaataactc caattaagct tctccccttc tctctgaatt tacttttaat 2018881 acgggctaaa ataaaaaagg tttcatataa aacgggacta gaaaacttct gtcactttaa 2018941 ttatttaatc caataaaata agctctcatt gcgagagctt attttattta gattgaggat 2019001 gtgcaactca agccttctat tgcgctatag caatactttt gcttaatcgt cccagtcttc 2019061 atcctcatcc cagtcatctt tcgcttcctg aatcttatta taaaaaaatt caataaagct 2019121 gtctgcaaca gtatcttgat aaccaattac cctatcccat tcaactacag ggcattctcc 2019181 gtctttcatt ttatttgtat ctagacagta agcaaagtaa tcaacatctt caataaccac 2019241 aagtccatca gtaaggccat agtgttcttt atattcatta gttctattta caactgatgc 2019301 atgatcaaag ttgtagccta aaaccaaaac gccgaataaa ccaccagcac cgtatttttc 2019361 taaaaaccat ttataactgt tggggagatc gcattggagg ttttcttcaa tgcgaccaat 2019421 gttttcatga cttgcacctt ctgtaaatat agcattttgt ttattttcat taataaagtt 2019481 ctcaaccttc gaataaatca tataaacacc tcaattctca ttttcaaatt gtttcgctct 2019541 ccatttccaa tatctctttc taaagctctc gtattgtgct tttaaaacct tatcatttct 2019601 aaaactttca ccatcagact taagctgatg aatgacatca ctatattttg tatgtaagct 2019661 gttcgggatt tcaagcattg ggccaggttc ttcttgaatc aagtgatgta aattaatctg 2019721 tgtaccgtct tttgcataag gggcattccc gtttttcatt agctgaagat ttgtaacacc 2019781 gaattctgtt ttttgattaa tatcaatatc tttcatagta tacactctac ggcttacatc 2019841 tttaactttc cccttcgcct ttaccttccc ctctatttca tatgcatcat acttttcttt 2019901 atttagccaa ggagggcttt tcttttggcc agtaaacggt tttcttgttc catccggtat 2019961 tttcttcgca ttagtcaaaa gttcattctt aaggttttgg ctatcaacca cattgtatgg 2020021 cacgttatct gctagagcaa gcttatactt agggttgtaa ggcagcaaat ctggaatctt 2020081 aacgtccttg attttcttac ctgcttgact tgctttattt attaccttgc ccgctgcatc 2020141 tgctttgtta atggctcctg caccttttgt accaacaaca gctacagcca ctgaaccaat 2020201 agcataggta acccatcttg atctagaata ggcatctcca ttcaccatat ccttttgata 2020261 tgactcttct attgctgctg aaatggcatc gtatgttttc actggatgca tagctgcatt 2020321 acccagtgct gagagtgttt ctcctggatc ggtgatgaag tcccatatgc cggttacagt 2020381 gtcttttcct acatcgtata aaccaactcc tacacctttt acgatatccc aggtgatttc 2020441 tcctgctcct tctagctgct tcgcttgttc aatttgcact gcaagctgca cttgagttgg 2020501 ctccagattc tcgtacccta ctttcttagc aatctctaaa tattcatcag ggtcagatac 2020561 accgtcatta agttttttct ttaattcctt gatttcacgt tcctttgctt cttctttctt 2020621 cacacttaag taagcttcag aatgcttttc aatatcgcct tttttcttat gtatgtcact 2020681 ttctctgtac gctttagcgt tatagtgaat tggtgtagcg ttttttcctt tgcctgttga 2020741 ttcctgcagc tttttaaagt cttgctgaat aaattgttcg tttggttctg tttcagcgta 2020801 ttctgttttt aaatcctcat caagcttgtt tagcttatcg attgtttttt cacgtttgtc 2020861 atctgcagaa gaaagtttgt ctttgaagtc ttctgttgag aatatttcaa ggggaaggat 2020921 atcattgatg ttgtttaata tgtctttcat tgcttttttc tgttcagaca taatggattt 2020981 tgattttgca taagcgttag ccaactcgtg ttctagaaag gattcttcta tgtaagcatc 2021041 agacatcttc gcatcttcaa gtgttgcaga catgctgctt aagaaagcaa tcttcatatc 2021101 gataagatca atccattggt ctgttacgcc gacatgacca tgataaaatg ctttaatgtt 2021161 gtcagcaccc ttgcctgaaa attcactgtc atctaggtta gctacttcct taaacgcttt 2021221 tttgagcttc accatttgcg accttagttc cttatactct ttggttcttt tatccgcttc 2021281 aaagagtaat gaatcagcct caaatacctt catatcattc tccttcctag actacttcta 2021341 tgtaaatttt accacagtaa tctaattgaa taacagaaaa agacagccaa aatgactgtc 2021401 ttatacatca cacactatct tgttctataa taattttctg cggtatagta gcgccaatcc 2021461 caaaaaggtt ccccattggc caatatatac cggtctaaaa atttttcaaa gtttaaattt 2021521 aatggattat attctaaacc actttcaaat atatagagat agttgggatc accttggttc 2021581 actttatctt tatcgatcat taaatggcat tcttccaata agtagccaat tggaatacca 2021641 ttgatatctt caaacaaatc ttcatatttt aactcctctt caatctcttc aaggctaaat 2021701 agctgaagtc ctccacctat attctcccca tcagaaagaa tctcaaaaat tttcgcaccg 2021761 ttatgtagtg tcatgaactt ctgataatcc tgtggaaggg taagctggtg tttagcctca 2021821 aagctttgaa tgtcattcag ggttgctttg tcctgtgaaa aagtaacaag gaactccatg 2021881 atatcacctt ctgaacaaaa caatttaatg gctccttttt cgtctaaaag acttttcaag 2021941 ccatttacag tcttatgaac aaagttagtc acatacatca cccctttatt tccttttaac 2022001 aataaccttt caaattccaa aagatgtgaa cagatcgtga taggtgctct tttcagtgaa 2022061 tataatgcaa taaattctaa aaagaggtgc ctccaaaaat tgaattctct aatgaatgat 2022121 gacatggtaa agatcattag aaatggcctt agcgcatcgc agcatccaaa gcacattctt 2022181 gttataggag ctggattgtc cgggcttgta tcagcatctt tgttgaaaaa tgccggtcac 2022241 agagtaacga ttctcgaagc gagcggcaga gcgggcggcc gtgtctgcac tttgagatct 2022301 ccctttagtg atgatttgta tttcaacgct ggcccgatgc gcataccgaa taaccattcg 2022361 ttaaccttag aatatatcaa aaaattcaaa ttgccaacaa atgtatttat caacagaacc 2022421 ccgatggaca tcatttatgc aaatggaatc aaaacacgtc tccaagtttt tgaacgagct 2022481 cctggaatat tgagatatcc agttgcacca aatgaacaag ggaaaacgtc tgaagagctg 2022541 atgctttctt tactgcagcc tattctaaat tttatcaatc aaaatccagc aagaaattgg 2022601 cggattgtcg aagaacaata caaaaatcat tcgttaagct cttttttaaa cacgtatttt 2022661 tcatatggcg cgatcgatat gatcggtgta cttttggata tggaagcgta tatggggatg 2022721 tcccttgttg aagtattgcg ggaatctatc tttttttcat cccccgctca cttctatgag 2022781 ataactggcg gtatggatct gctgcctcac gcgtttcttc ctcaattaaa aacaaacatt 2022841 ctataccatc aaaaaatgat gaaaatgtct cagggtgaaa atcgtgttac gatccattgt 2022901 cagcatcaac aaacggcaga attcacatca ttcacagctg atctcgctat tgtaaccatt 2022961 cctttttcaa cattgcgatt tgtaaaagtc gaaccatacc attcattctc ttactataaa 2023021 cggagggcca tccgtgagct aaactatatc agtgcaacaa aaatcggcat agagtttaaa 2023081 agccgatttt gggaaaaagc cggtcagcac ggcggcaaat ctattactga tcttccgatt 2023141 cgtttttcat attatccaag cagaaatatt ggagcaaatg gacatgctgt cattctggcc 2023201 agctatacat gggccgatga ggcactgata tgggacagtc tttcagaagg agagcgaatc 2023261 cagtatactt tactgaattt atctgaaatc tatggtgata ttgtgtggtc tgaatttgtg 2023321 tctggcactt cttttagctg gagccagtac ccgtattctg cgggaggttt tacagctttc 2023381 gaaccaggac aagaattaga gctgtatccc tatattcctg tccctgaggg cagagttcat 2023441 ttcgccggag aacacgcctc actcactcat gcgtggatgc aaggcgcgat tgaatctgga 2023501 atacgtgttg cttatgaggt caatcgctta ccttagatca tgctcacatc ttgttaaaac 2023561 tggttgatat aaaaagaagt gaagaattta tactcctttg tttaaaagat taattcaaat 2023621 atgggatgtc tcaacattcg gttctttatt atctttatac acgttttgaa tgcggacctc 2023681 ccttttcttc cataatcatt aataaatacc caaccatagg aaacgtttta attaaccatc 2023741 gggcgaactt tctttcactg tataacgatt cttaatgttg ctttttatcc tttacttgtc 2023801 ctctcttttt ttcattgact tacatttctt gaaaaccagt ataaatccta aaggaatttt 2023861 gtaacaaata cagaattgga aagagaagcg ccaaaagaaa tgctaactcc ttatctcaaa 2023921 gacaaaactg cgcttatatt aaaagaaaga ggtgtcttta gaatggttca ttttaaaaac 2023981 tgccctgatc cttctctaaa cgccaattct cagtctcacc ccgaattttc atccgaatta 2024041 gaacatatta agacaagaat gcaaaacttt attaagcact cggttacaga ccaaaatatc 2024101 gaagttactg acgcaagggt gacggccgaa ggagaggtca cctctctttt aaaagaacgt 2024161 ctcgacaagg aatattatag gcttttatct aaaatcaccc gggaagtaaa tgtggctgac 2024221 ttcggcgctg ttccagatgg aagagacaat actgaagctt ttcgaaaagc aatcgggaat 2024281 ggccgagtca aagtacatgt tccagcggga gaatacctcg ttcaagggat taaacttcca 2024341 tcttggacaa caattgttgg acaaggtaaa gggatcacag tgattaaatt gcatgaagac 2024401 actccagcgc atgaatgggt gattacaaat gatgattatc aaaatggaaa tcgcaatatt 2024461 tttgtccaag gaatgtcatt agactggaat ccaagtagac aatgcggtgt gagaaatcca 2024521 gggggacagt tctccagttg tttaactttt gctaaggttg aatatgggtg gatcaaagat 2024581 gtggaagcga ttaacgcagg tcttcatggt attgatatta catcgccaac gtatgaccat 2024641 ttgcctgata ccgattggac aaaagacgga tcaagatata tttggatcga taactgtgtg 2024701 acatatggtt caggagacga cggcattacc acccattata gcgaatacat ctttatttca 2024761 aactgccatt caggaaatcc gcggggaaca gaatttgctg aaggtgtttc aaactccaac 2024821 ggaatagaaa ttgacgacgg ctctaggcat gtgtggcttt tgaataactt tacaagcggc 2024881 aacatccgcg gagttgaagt aaaagcccat gaactgtggc cagcctctca aaacgtccat 2024941 atcataggcc atatttctta tcgcgatgtt cgtgcatttg atcttcgtca tattggtcac 2025001 catcaaatta cagatcctga aagcacaaca gcatacgatg tcacactcat tgattgttca 2025061 gcagttgaac cagttttcaa ctcgctttac gatgctgtga ccccaagagc gctggttatt 2025121 tcggcatata aaaacgttaa tgtaagcgga ttcacagcga ttggtgatcc agactatgat 2025181 tataaagaaa accctgtcgt agccttgcaa tatcgcagcc aaaatataac cattaatggt 2025241 attaaaattc gcggttttaa aaaagccggt gttgatatta atttatcagg cggatcaaat 2025301 aaaactgatt atattaaaat ttcaaatttt gatatttata aatctgctcc aaaaggaatt 2025361 tcaatcggtg gaggcctcta caatgtcaat attctaaatg gaacgatgat tactgacaat 2025421 gggacagttg caattcagtc ccccaataat caggccacaa ttctcggtgt acaatcagaa 2025481 ggttatagtg tggcagcctc aatcaaaggc caaacatacc aacaagttcc aatcaatttg 2025541 aaaggaggca tacagcttgc aacgacctct ggctttgccg ttaaccaaac aagcgcagtt 2025601 atagcaggta ccggcgacat tacggcccgc ggagaaagaa atgcggtcat tagctcttct 2025661 ggaggctcca gtactgaagg ctctcgcgca ttaatcgctt cttcaaataa cgcacatatt 2025721 agaggaaacc aagcgtcaag aacaatactg tcttctgaaa atattatact tgaggaacca 2025781 tacaccgtgg caggaggtca tcaatcaata aagtggcttc ttgactctgt tcggggaaac 2025841 gggacgtttg ccggtgcaat cagttcttct ttaggtggat atggagagta ttttgagagt 2025901 tcaactggac agttaatcca tactggtaca atcgtgactt taagaggtga aaaaattgtg 2025961 cccgcgaatg ttggagatta tatgcttggc gttatttcag aaacttcagc tttcatttca 2026021 ggagcctcca gtttcgtctg gcagggccgt tatttgacaa atgagttcgg cggatttatt 2026081 tatgaaacgg tgactgatga ggaaagcggt gaactcatac gtgttcccaa acaaaatcca 2026141 gactacgata cagcgctgga ggcaaattat cattcacggg cagcaagaga cgaatggcac 2026201 gttgtagggt tggttggcca acattatgtg cgtattgacg aaactgtcaa tcaaggagat 2026261 tatcttacgg cacataatgg aataggaaca aaagccactg aaggaagctg gaaagtaatg 2026321 aaaataacct ctgcttacac atcagaaaaa gggtatggta tcgctctaac cgtcatcaaa 2026381 tagtggatac gccgaccagt tcaatatatg tttatccaaa taattagatc tcttttctag 2026441 gttctttatt ccttgtatgt tattatcaat tttcaatatc taccaaaata cccctaatat 2026501 actatcgtaa ttaacttata ttataatcaa aaaaattttg acagctgttc cttctcgtta 2026561 ttcatgaaag ttgctattga aatgagtaaa tggatatcat attagacttc tatagcaaat 2026621 acaccatata tatcctttaa gtatttacaa attgaaaatg tttcatgagg cttattaaaa 2026681 gtattgttct tttatcatct gtaagtcgat acaaactgca ttaagatcac acctaaatct 2026741 cactgagttt tttcttacaa ataaaatgaa aaccctttcc attctaaatt catttcaccg 2026801 ttactaaaag taatccttgc attccttcgc cctccatgct atattcatat agcgatgagc 2026861 tgaattgtgt aagccgatgt acatgccttt acggcacaca cgaatgtggc gtgtggtgca 2026921 tcgcctcaat acgcaaagac gtttgcctta ggcaaacgtc tttttttgcg ttatccgatt 2026981 tttgtgccgt ttgggacagg ctgatccggc tgcaaaagga cgacgtcgcc ctggccgggt 2027041 atgccgccga ggaccaagac ttccgattta aatccggcga tccggcgggg cggaaagttc 2027101 acgactgcta tgacttgctt gttgatgaga ccttccggct tgtaacgctt cgtgatttgt 2027161 gcgctcgatt gttttatgcc gatttcagtc ccaaaatcta tcacaagctt gattgccggt 2027221 actcttgctt caggaaattc ttccgctttt acaattgttc ccgttctgat atccaatttc 2027281 tcaaagtcat caataactgc catatcaata actccttttt ctcctattgt aaaggagata 2027341 tacaatattc ttttaactaa agagccatca ttttttatcc gaatataagg tgtttcgata 2027401 caggcggggc ggcattcctg tgcttttcgt gaaccatctt gtaaaagaag aaaggttttg 2027461 aaagcccagc gcctcgctca cgacggtaag agtttcattt ctctccatca gcattctttt 2027521 tgcttcctca aggcgaaggt cggcaatata gttctgcggg gacttccctg tctgtttttt 2027581 gaaccagctt gaatagtaag ctgggtgata atgctcgatt tctgccagct tcttaatcgt 2027641 cagccgctca aataaatggc tgtgaatgta tgcaattgag gcatagctat gggattgaag 2027701 cttttctttt atgtattgta ctagcatatg aagcgagttg gctgttccgg cctttgcttc 2027761 ctctgtcagc aagtacctga tcgaagacca gaaaggatcg agggcagctt caattcctga 2027821 tcctgcacga tactcatcaa ttttcattgc atgaagcgga acatccagta caagacattc 2027881 atttcttccg atagaacgga agcgatgctc gcactgcggc ggaatatata aaaaatgatc 2027941 cggatttaat ttcacctggc gcccctcagt ctcaagatca atactccctt caagcggaaa 2028001 aagaaattgg ctgtacgcgt gcttatgtga atgatatagc cgtgtgtatg tccgtttttc 2028061 gcaaattatc tcttgaagcg agtccattag caaacccctt cctttggtca tcttttaatc 2028121 cggtaatggt gttccgatat aggcgaaaag ccgatttttc catataaaga aactgccgcc 2028181 agattttctt tcatcacttg taaaaacatg cgttccgctc cgttgttttt tgcccattca 2028241 gtcaacaccc tgatcacttg ggttcctgcc ccttttcctc tgtgctcctc agctacaacg 2028301 atattactaa gtccgccata accatcaatg acagaaaccg tgccaagcgc tgtcaggctt 2028361 tctttgtcat acatcttgaa aaaagtttta cacggcggca tgcgttcgaa tatgtgtttg 2028421 taacctttgt gacgctcggg tgaaaaccct tctaattgaa taaattcatc tatccaaaca 2028481 gatgatggct cttgttccca cttgtatgta aatcggctgt tgtcatttgt tcggctcata 2028541 attgaccggc acaacgctgt catctggaag cactcgtcta ccttttcata acggctgtct 2028601 gccaatgcgt catcaagccc tttcggtgat gcgttgctaa tatgaaaaca aacaggtaag 2028661 cctaaacttt gataaaaaag ttcggcctct agctgaaaat ccccttcagg catatccgca 2028721 gacgtccata cgctatttgc ccttttggtt acgccaaaat tcgctctgag aagccatttc 2028781 cctatgcttt tttgaaaata agccggccat gaagctgccg ctaatcgttc aatcttgcga 2028841 atgtcatcca ttgcataatg cctctcccct atgtatactc ccttgatatt atacaatatt 2028901 cagaaatata agacatccat ttatttgttt acataatatt tttattgttt attaataatc 2028961 ctgacaaaaa tgtccgaatt gaaaatgaca ggctttctaa aatgtcctcc tcacgttcaa 2029021 atgcttcttt tgcgattaaa acagtaaagc catgcagcag acttctgagc ccccttgtcg 2029081 catgaatggc agtcttttca cttgcatagc cgttttcaat gagcagcttc gtcacaagac 2029141 agacaatttg gtcagagacg atttccgtcc gtttgtcgtg aaccttaaga agagccgctt 2029201 cataatatcc gggattttca attgcaaaat caacatatgc atgagctaaa gaaagcatcg 2029261 cggaatctcc ctttcgttcg gttacggagt ccgccatttg atcaaaaagc tttgtcagtc 2029321 ctctgacagc aagttctgct ctgatcgctt gcagcccgtt gatatggtta tacaatgacg 2029381 gggggcgaac attcattttt ttagaaagtg cagcaagtga gacaccattt accccttcct 2029441 gatcggcaat ctctgctgca gcgtctacaa tcattttttg ggtcaaacct attctcggtg 2029501 acatgctcat catcctttct ttgctttttg gatcgcctgt ctcatccgct ctgaaggtga 2029561 tcgcaggaat tttccatgtc cgacagcgag acaggaaggc gccttatcgg cgagcaattg 2029621 tgcacttttg atggcctcct ccttattcca tgtggcgaaa gcgggaaaag gaaacgccca 2029681 ttttatctga cctgatacag cgattcctcc gcgcaactga aacgcatctc ctgctattaa 2029741 agtgccgttt cttgtatcaa gaaatgacat gctgcccggt gtatggcccg gtgttggaat 2029801 ggcaagcaga gaaccaattg tttcaccgcc cgtcagcagt tggtgaggct ttgtttgtat 2029861 gtgtttcgga atacctcctt ttataggcgt ctgcggctca tcttgccgca aagatgtgtc 2029921 accttggagc aagaatgaat cccgttccga gatcatgacc tttgcatgcg gaaatgtttg 2029981 tgccaatgta tccagtgatc cgacatggtc cccatgtgca tgagtcagta aaatatgctg 2030041 aagcggtttt ccaagctgat tcacagcttg aataatccct ttatagctgc ctggcagtgc 2030101 ggcatcaata agggtgactt cgttttcttc ctctactaaa tagcaattaa ccggaaacaa 2030161 tgctggaaaa aaagtcagct gccaaaccgt ttggtactga gtaattctca tctttttatt 2030221 cctcctaaca aaaactaatg gtgttagttt tattattaac taacaccatt agtttttcaa 2030281 gagtttatta tttttttatc gctacataaa tgttaacttg tgctcgctgt ggcactgcgg 2030341 cattttgatc atacatctca aagtcacctg taaacgtgcg cagatgccgc ttatcccaag 2030401 tccaaatttc cttccacgtt tcaagcacaa tctcttcaat aggaccgatt ctggaagtga 2030461 aaacggcgta agcggaagcc ggcaaatcaa tattttcata tggtcccgga agaatgtcgt 2030521 cgtattcctg aaacgttccg actgaaaacg tataaaaccc attcgtctct tgttcataat 2030581 tcgaatataa ggcaataatg ctcttgtctt tttcagcctg tgataaaaga gcgctcatat 2030641 cctgcttcca taattgatcc cacagtgccg gaatcctcct ttcttccgtc atttccagtg 2030701 cgttgcttgt ccgttgtgat agtccggcaa atcgtttcag gtctaagtgt gttatatgtg 2030761 aaaagcccat acgatctcct ccttttttta agattataga caaagaaacc tgacagcagt 2030821 gtgtcaggtt tcatatattt tttgcatgtg atgaatggtt tcttttactt tatcccttat 2030881 atgaagaggc tgcagaacct caatatcctt tccgaactgg agcaaaaaac cgatcagcca 2030941 ttgatcttct ggaagtgaaa tcaccgcctg gcagatttca tcttcctcac aacagtgaag 2031001 gacatcatat ccgaaccatt cacctatacg ctgacgtgct gacggctgaa caagaataac 2031061 caattcagtt aaacggtcct tttggtacca actcttatcc catggcaaag tgtccagctg 2031121 aatgtctttt ctgataaatg tctgatgtaa gatggccaga tctttcatcc ggttcagttt 2031181 aaaaaagcga aaatcatttc ttaccaggca gtaggcatat aaataccagt gccccgcctt 2031241 gcaaaccaat gtataaggtt cagtttcccg aagtagtgtt tccccgcttg cgcttgtata 2031301 tgtaaaagat atcgttaaca accgatcgat ggcagcgctg attttctcgc gcagcgtctt 2031361 ttgatcctca gtatggcccc aagccgtcat gtcaataaac catttttctg tttggtgctt 2031421 aaatgcttga gtagattgct caggtataag gtgtttgatt ttttgatagg ctgtgctgtg 2031481 agaaacgggt tcatacatag atgaaacgct ttgcaaagcg gaagcaattg caaacaattc 2031541 ctcctccttc agccactctc tttcaagccg atacgtttcc atgatgccaa ttccgccccc 2031601 ggaaccctgt gaggtcacaa tcggaatacc agccctattg atcgtctcaa tatcacggta 2031661 aattgttctg acagatactt caaacagctc agcaagctct gcagcctgca cttgtttttt 2031721 gctgatcaat aacacaacca tcgctaacaa acgttccagt ttcattctgc gcaccttttc 2031781 ttcttgtatt ttccaacaaa acaatcataa cattttgata aagcttgggc atatctatta 2031841 tgcggcggaa tacacctcgc atatgctatg aaaacagggg tttccccttc ttttttgtgt 2031901 tcagtattta tttcagctac tatttccgac cggataagca tacacttctc aacggagggg 2031961 atttcacatc atgcatctta cacttcagag cgtttatcct gccataatca tcatcttttt 2032021 tctgtataaa aaaattaaaa ggtccatcgg ataccagccg ctgaagcccc gctggctgtt 2032081 cacccgtatc attcttttct cgctgtttgc ttttggactt tcaatcttca gcgccattca 2032141 ccctttttta tatggatatc tcattttggg cattcttggc ggatggctcc ttgtcttttt 2032201 cgctaagaaa aacatctctt ttgaaaaacg cagaggaaag atctattttc ggactcatat 2032261 ttgggtagag gtgattctct taactttatt tctatcaaga tttctgtatc gagtgacgga 2032321 gctttatctt acctcacctg atctaaaccg ccttggatca tacagtcagt caatcggaac 2032381 ggaccctctg acaattggcg tctgttttct gatagccgtt tattatatcg gtttttcttc 2032441 ttttatcatc aagctcagca gaaacgaact tgaacagcac gaatacaata aagaaaaaga 2032501 catccttgcc cgctaacagc gagttaagca aggatgtctt tttcaatcat gctgtgtatg 2032561 atggatcatt tgctgaagaa catctaaaac atgttcatcc tccggagagt aataaatcga 2032621 tgttccttct ctgcgcgatt tgacaagccg gagatttttt aaaaatctaa gctggtggga 2032681 cacagtggat tgcagtaaat tcagcttttc tgcaattccg tttactgcat gctcaccttg 2032741 ggacaataaa tggagaattc tgattcgggt aggatctgaa agcgctttga atgtttgcgc 2032801 gactagaaac agcgtctcct cgtccagatc agcagccgat tgttccgttt ctctaaattc 2032861 agtcatatgt atcacctttc tttattcata gttttatctt ataacaaatg cgcttgagtg 2032921 caaaccagcc tgcttgtatt ccatttcaat ctcatagttt aaatttatgt ttcaaatcag 2032981 gtttttactt ggtctgatat accctcttat gtcataataa aaaaggtcat actgctccaa 2033041 acattgaggg tgaaacacag tgaagaaaaa gagaaaaggc tgtttcgctg ctgcgggttt 2033101 tatgatgatt tttgtctttg tcatcgcctc ttttttattg gtcctgcttt ttttcaaccg 2033161 ggatttaatc aaaaaacttc cgatcgatac gaaaacgatt gttttggaac gtttaaccga 2033221 ttacaaaccc ttggtggaag aagagcttga aagccaagga ctctctaatt atacatcact 2033281 catattaggc atgatgtatc aggagtcaaa aggaaaaggc aatgatccca tgcagtcctc 2033341 tgaatctctg gggttaaaac gcaatgagat aacagaccct caactcagtg ttaaacaagg 2033401 catcaagcaa tttaccctca tgtacaagac cggtaaggaa aaaggcgtgg atttggatac 2033461 cattattcaa agctacaaca tgggggcagg ttacattgat tttgtagctg aacatggagg 2033521 aacgcatact gaggaattgg caaaacaata ctccgagcag caagtcaaaa aaaatcctga 2033581 tctgtatact tgcgggggaa atgcgaaaaa tttccgctat ccgtattgct acggtgatta 2033641 tacgtatgca gaaaaagtaa aagaaaaaac aaaaactgtt gaagaatctt tgcaggttgc 2033701 aacacttgaa accatggaat ccaaggctca tgaataagag tctatcaatt tactgacaaa 2033761 agcccaaaaa tgaatttggg cttttgccat gtttacacgt aaaaaaagcc atactgagta 2033821 tggcttttaa taatacggtg aaatcatcaa atatacaata acgcctgtaa ggcttacata 2033881 cagccataga ggcattgtcc atctcgcaat ttttttatgg cgctccacct gcatgctgaa 2033941 gcctctgatc agcgtaaaca gcgcaagcgg cacaataatt gcagaaaggc agatatgtgt 2034001 aattaaaata aagaaataaa tcgggcgcat aataccttct ccgccataga gcgtgttttc 2034061 cgcaatcgag tggtacgtca catagcaaat caaaaatagt aatgttgttg tgaacgcagc 2034121 caaaataaag cgtttgtgag ctttgatatt tttctgttta atcataatca gcgcggccaa 2034181 taagaagata aacgtaaagc tattgaatat cgcattcagc attggcaaaa tgtgaatatt 2034241 cgcatggctg aactgatcta atttaggcat aaaaaacagc actgcgatta aaccgttaat 2034301 cagaactgtc agcgtaagga caatccccgt gtaatttttc ggtttatttt ctgtttggtt 2034361 catttggtga cctctcctaa tttgtactgg ctatccaaat cgtatgcaaa ttcaaagaag 2034421 atgtcaacgg tttcgattgc ttcgtcagaa attagacaca cttcaaaggc cggaggctat 2034481 tagccccggc ctgttaggtt tacgcctctt ttatcaaatg ttcaatgacc ttatgttcat 2034541 tttcattcag caggttcttt tgaattttcg aatgaatggg tttattcata tgctgatcca 2034601 agatatcggc cgtttcttta tccccggcaa taaccattcg ttcccatctt ttcgcggcag 2034661 ctttttgatc aaggctggca gccagccgct tatacagtct cgattggttc tctgttacat 2034721 gttccctcat ccggttctct tcaaatggtg gcgctttgtc tacagcggaa tggctattct 2034781 tccaagactc attgatcata tcatactcat aacgctccac cgcctcaatt tttcctaaaa 2034841 cagtttcaat aattttcact tcatgctgct gagttaaaat aaacgccgta cttgggtatg 2034901 tctggcgcaa accctttagc tgatccagga cagctgtttc ttcccagtaa aatcttgtat 2034961 ctacagggac ttgaagctta ataggttccc atatgccgct gtcggaaaca aaaaacacga 2035021 gactgcgggg catgtctttt cccattgcat tcaagtattg attcatttta gccctgattc 2035081 catccagaca cttttcctcc tctggatcac tagctgccaa atactctttt aatcggctga 2035141 atcctgactt tagggcaatc ttccattctc ccccctgctg ctctggatct ctcatgtctg 2035201 tattgagata cagagagaga attttatccg gcggttccaa ttggacatac tgtaatttgt 2035261 taatcaatga atcaatcgcc attccgattc ctcctttttc acaggttagt tttctttttc 2035321 ctctcttaaa aacgatcaaa cctgactttc cgctaatttc tagtaataat ggaattgttg 2035381 tttacaatac gcctctcttc taatacaatt ggtaactgtg tttctaagct gttttttgaa 2035441 aggagtttga tcttgtttac tgttaaagaa aaaaatcgtc aagagcttga ggaagaacta 2035501 aatgatttag aatttcaaat ttatcgcatg caggagaata tgaaggattt atctaaagat 2035561 gccaaagtgc ttggtattga tcaatcgaaa catgatgagt ggatgattgt ttcctcgatt 2035621 gatgatggcc aaacatgcaa aattatgcta actgattgta aaacggcata ccgaggaaaa 2035681 ggctgttttt cacttgtagc gtcttacaag gacgatgcca ttcatatagg ggatataaaa 2035741 ggccctccga atcacgggtt tggctccatt tgcatgaaat atttaaaaga tattgcaaga 2035801 gaccataata taccgaaagt caccggagac atcgccaaac gggattggaa tcatgtagac 2035861 cggctgattc acttttatga aaaacatcac ttcaaagtat gtatcgatca tgatacccaa 2035921 tccggcagca ttaagtgggt tgatttgtaa aaaagtctgg aagaaagagc caagatatgc 2035981 tgtaatggta taaaaccatt gatggagggt tctatgtacg cctcaaaact gaaaaaggga 2036041 gacgaaatcc ggatcgtgtc tcccgcgacc agcatgtcta tattatcaaa tgaagcaaaa 2036101 atccaagcaa aaacggcgtt agaacgctta ggttatcggg taaccatcgc tgaacacgca 2036161 aatgaatgta acgaatttga ttcatcctct atcgagtcaa gagtccatga tctgcacgct 2036221 gccttttttg atccaggcgt caaagcgatt ttaacgacac tcggagggtt taattcaaat 2036281 cagctgctgc gttatcttga ttacgagaaa atcaaacgac atccaaaaat tctgtgcggt 2036341 tattccgata taaccgctct ttgcaacgct atttatcaaa aaacgggtct tgttacgtat 2036401 tcaggtcccc acttctcaac atttgcaatg aaaaaaggac tcgattatac agaggagtat 2036461 tttctttctt gctgcgcttc agacgatccg tttgaaattc acccctcaag tgagtggagc 2036521 gatgatcgct ggtttttgga tcaagaaaac aggcgttttt atcctaataa cggccctgtt 2036581 gtaatccaag aaggttatgc ggaaggtact ttaattggcg gaaacttatg cacgcttaat 2036641 ttgctgcagg gaacggagta ttttcccgaa acagaacata ctattttatt gattgaagat 2036701 gattatatgt cagacatcca tatgtttgac cgcgatctgc aatcactcat ccacctcccc 2036761 gctttttcac atgtaaaggc gattttgatc ggcagatttc agaaagcatc aaacgtatca 2036821 atagatcttg taaaagccat gatcgaaaca aaaaaagaat tatccggcat cccgatcatc 2036881 gcaaatataa atgccggaca tacctcgcca attgccacgt tccctatagg aggaacatgc 2036941 aggattgaag ctatttcggg tacatcacga atatggattg ataaacatta atcagcttgt 2037001 aaattttttt acaagctttt ttagcgcaat cggctatgca tgccgcacga gacatgacaa 2037061 atgtcatata ggaggcatga tgtgtgctac tacaaaagac ttctctcatt agcgtatact 2037121 gaaccgagac acacaatgag aggatactta ctatgactga acaaaccatt gcacataaac 2037181 aaaaacagct gacaaagcaa gtcgctgcat ttgctcagcc tgaaacaaaa aacagcctga 2037241 ttcagctttt aaacacgttt atcccattct tcggcctatg gtttcttgct tatctcagcc 2037301 tcgatgtctc ctatcttctt acgttagcat taacggtgat tgccgcaggt tttctgacaa 2037361 gaatttttat catcttccat gactgctgcc atcaatcttt tttcaaacaa aaacgctata 2037421 accacattct cggttttctg acaggtgtcc tgactttatt cccgtatctt caatggcagc 2037481 acagccattc gattcatcat gcaactagca gcaatctgga taaacgcgga acaggagaca 2037541 tctggatgtt aacagtaaac gaatataaag ctgcatccag acgaacaaag cttgcataca 2037601 gactttatag aaacccgttt atcatgttta ttctcggacc gatttatgtt tttctgatca 2037661 cgaaccgttt taacaaaaaa ggcgcaagac gcaaggaacg tgtaaacaca taccttacga 2037721 atctggcaat tgtcgcgttg gctgccgctt gctgtctgat ctttggctgg caatcgtttt 2037781 tactggtgca aggcccgata tttctgattt caggttcaat cggtgtttgg ctgttttatg 2037841 tgcagcatac ctttgaagat tcttattttg aagcggatga aaactggagc tacgttcagg 2037901 ctgctgttga aggcagctca ttttataaac tcccgaaact gcttcaatgg ctaacaggca 2037961 atattggtta ccaccacgtt catcatttga gtccaaaggt gcctaactat aagcttgaag 2038021 ttgctcatga acatcacgaa ccattaaaaa acgtaccgac aatcacctta aaaacaagcc 2038081 tgcaatcact tgcgttccgt ctatgggatg aagataacaa acagtttgtg tcatttcggg 2038141 ctataaaaca tatacctgta agccttccgc ctgattcacc agaaaaacag aagctgcgga 2038201 agaatgcctg atgataaagg aggtcttcta atatactaga aggcttcctt tttattgttg 2038261 gagggtgcat tctggctttc acaatgataa agttacaagt aagatgaaaa gctgaaaatg 2038321 aggtaagatc atgattaaaa atcattttac atttcaaaaa ctaaacggga ttacgcccta 2038381 tatatggacg atatttttca tcctcccctt ctactttata tggaaatcat catctacatt 2038441 tgttattatt gtcggcatca ttttgacgct tttatttttt tcggtatatc gatttgcttt 2038501 tgtctcaaaa ggctggacca tttatttgtg gggattttta ttaattggca tttcaaccgc 2038561 ctccattact ctgttcagtt atatttattt tgctttcttt attgcttatt ttattggaaa 2038621 cattaaggaa cgcgtccctt ttcatatttt atattatgtc catttaataa gcgcggccgt 2038681 cgcagccaat ttcagtctcg tattaaaaaa ggaattcttt ctgacacaaa ttccttttgt 2038741 cgttattacc ctcatcagcg caattttatt gcccttcagt ataaaaagcc gcaaggagcg 2038801 cgaacgactt gaagaaaagc tcgaggatgc aaatgaacgg attgcagaac tggtaaaatt 2038861 agaagaacgt cagcgaattg cccgcgatct ccatgatacg cttgggcaaa agctttctct 2038921 tattggttta aaaagcgact tagcaagaaa attgatatac aaagatcccg aacaagcagc 2038981 tcgtgaactg aaaagtgttc agcaaacagc gcgaacttct ttaaatgaag taagaaaaat 2039041 cgtttcctct atgaagggca tccggctcaa ggatgaattg atcaacatca aacaaattct 2039101 cgaagcagct gacattatgt ttatctatga agaagagaaa tggcccgaga atatctcatt 2039161 gctgaatgaa aacattttga gcatgtgctt aaaggaagct gtcacaaatg tcgtcaaaca 2039221 cagccaggct aaaacttgcc gagttgacat tcagcagctc tggaaggaag ttgtgattac 2039281 agtgtctgac gatggaacat tcaaaggaga agaaaattcc ttttcaaaag gacatggctt 2039341 actcgggatg agagaacggc ttgagtttgc aaacggaagc cttcacatcg ataccgaaaa 2039401 cgggaccaag cttaccatgg caattcctaa taattcaaaa taaacataaa ggatggctta 2039461 tatgattagt atatttattg cagaagatca gcaaatgctg ctgggcgctt taggatcact 2039521 tctaaacctc gaagacgata tggaagtcgt aggcaaaggt acaaccggcc aagatgctgt 2039581 tgattttgtc aaaaaacgcc agcctgatgt atgtattatg gacattgaaa tgcccggaaa 2039641 aacagggctt gaagctgctg aggagctaaa agatacaggc tgcaaaatta tcatcttaac 2039701 caccttcgcc agacccggtt actttcagag agctattaaa gctggcgtta aaggctattt 2039761 gttaaaagac agtccgagtg aagagctggc caacgccatc cgtagcgtca tgaacggaaa 2039821 acgcatctat gcacctgaac tgatggagga cttatacagc gaagctaacc ctcttacaga 2039881 tagagaaaaa gaagtgctcg aacttgtggc tgacggtaaa aacacaaaag aaatcgctca 2039941 ggaactcagc atcaaaagcg ggacggtgcg gaattatatc tcaatgattc tagaaaagct 2040001 tgaagtgaaa aatcgaattg aagccattac ccggtcaaaa gaaaaaggct ggtttaaata 2040061 aaaaaggatc ttggcatctg ccaggatcct ttttgttaac ctgaaattcc cgtttgagaa 2040121 cctcgtcgca accagaatta aattgatcca tatcctcgct cctacgcccg ctgaacgatt 2040181 gtttggttaa cagcccaata aaagactgga ttgaatgata tccctgttaa aatggtcggc 2040241 cattgcacat cagcagaatt tctgatattg attatattgt attttcagta tgacaaagtt 2040301 gtgccacttc gctcccgaag ctgccatgcc caactgcaag agcctaatat cacaataaaa 2040361 aaccgtctga aatcaatccg attccgtaaa tggtatctgc tacatccaac tgcttattat 2040421 ctgccaaaaa caccagctcg tttcgctgat caaagatagt aacaaccagc tataaatgtc 2040481 atgatgccga atgtctctgt aatgtggaat caatctttta acccgagagc ccctgaatcg 2040541 cacataaaga aaaacgggac cactttcttt tatcagcata tgatataaac agctctaagc 2040601 agaacaaaaa aagacacaag ccaaaagctt atgtctttta tcacaatcta tattattagt 2040661 ttaagacttt aacacttaca gttttgacgc cccaattaga agcatcactt ttacttggta 2040721 caaatacgtc gattttattt cctttaatag cgccgccagt gtctgctgct gttgcttccc 2040781 cgtagccttc aacatagact ttagaaccta gcggaattac attaggatca accgcaataa 2040841 ctttcgcgtt cgggttctta tttaagtcaa tgcctgtagc tgtaacgccg gaaatgccgc 2040901 cgtcgttagc agtgtaagca gtagcagtaa ctgttagttc ttttgaagct tcttgattat 2040961 ttgtatttga ttgaacagcc ttctcctctg tgttaacaga agtttctgcc tcagcctttg 2041021 tttcttgttt aggttgctgt tgtacagctt cttgtttagg ttgctctttt tgcacagcct 2041081 cttgttttgg cgcagcttga ggtgcgtttg tttgcgcatt ctcagtagct gtgtttgctg 2041141 ctgttgcctg accttttact gaaagagttg atccagcata gatcatgtca gagcttaagt 2041201 tattccaaac tttcaggttg ttgactgtcg tgccgaattt ttgagcaatc ttagaaagcg 2041261 tatctcccgc tttaattgta tattgcccag tcgtggttgt ttcttctgaa gaaatggtca 2041321 gtttttctcc tgcaatgatt ttatcagaag ttaacttgtt ccattctttt aagtccttta 2041381 ggttcactcc atttttctga gagattcccc agagcgtatc acccttttgc accgtaattt 2041441 cttttgcaga agcgtgagct ccgaatgcag ttgttgaaag tgcagcaact gccacaaagg 2041501 acataatcgt cttcttcata agtaaatcct cccttgttag ctttttattg gcggctaaca 2041561 ggtgatatcg taacacacgt aaatgtcaaa tcaataacaa aaagatatga tttagattac 2041621 agttccttta catgaaggat ttctctctga tggaaagact tgctgaaccc ttgatataat 2041681 aggcttcgca ggtcttttta ttttgaggcg aaacagagaa aataaaatgt gttttttata 2041741 gaaaaaaaga ttgtttttct gtttttttag tctgtcatcc ttgcataagc ctgtatttct 2041801 tgtaaaaaaa gccggccgta ttttgctctt ttttgttctc cgactccttt tatagacaaa 2041861 agttcatcat catttacggg ctgttttcct gacatttctt ttaacgtttg gtcagagaaa 2041921 acaacaaatg gcggaacacc ctgctcagcc gcaatttctt tccgaaccat gcgcaatcgt 2041981 tcaaatagct cgtcattttc agtaatcgct gccgctttta acgcttcttt tctcgctact 2042041 gataattctc ctttcagcac attccttcct ttactgctga caaaaagagt cggaaacgtt 2042101 ccgtctgaca tcctgatgaa gtcgtcagaa ataagaaatt cgataaaatc actgatttcg 2042161 ccaacggatt ggtgttttaa tatcccgtat gttgaaaggt cggaaaagcc gttttcaaga 2042221 acttttttat ttttggagcc ggcaagcacc tgggcaacca tcgtcttgcc aaaccgttct 2042281 ttcatgcgaa tgatacaaga taagaccatt tgcgcctccc gcgtcacgtc atgggccgct 2042341 cttgtatcgg tacagtttcc gcactgtccg cacgcatcag gctccttttc tccgaaatac 2042401 ataaggataa aacgctgcag acaatcttcc gtatgacagt agtcgaccat ttgtctcagc 2042461 ttttttaaat cctgcttttg tttctcttca tgttctgatt gctcaattaa gaagcgctgc 2042521 accataatat cctgcggtga aaacaggaga acacattcac tggcaagacc gtcccgtcca 2042581 gctcgtcctg cctcttgata atagctttcc atatctttcg ggatttgtgc atgcagaaca 2042641 aatctgatat ttgatttatc aatacccatt ccaaaagcag aggttgccac catcacttga 2042701 agctcatcat taagaaatct ttcctgctgc tcttttctca catcatcagc caaacctcca 2042761 tgataccggc ctgccctgac ctgatttcgt ttcaatctct catatatccg atcagcttct 2042821 tttctggtcg ctgtatagac aattcctgct tcatgcctgt tgttttgcac atattcgtct 2042881 ataaaccgat ctttattttc tccttttact actttaaagg ttaaattctc tcgggaaaat 2042941 ccggtatata ccgtgttttc tttttgaata tgcagctgtt tgcaaatatc atcatgaacc 2043001 tcgggtgtgg ctgttgctgt taacgccatg atgacaggct tgtcgtgtaa ttcacggaac 2043061 aagatttcaa tattcctgta gcttggcctg aaatcatggc cccattgaga aatacaatgc 2043121 gcctcgtcta ttgcgaccaa aggaacatct atgccctgca aaatccggat aaactctatg 2043181 gacgttagtc gctctggtgt aatgtaaaaa agcttataag ccccttcttt gagtccgttc 2043241 agcctctcat atatttcctg attggattgt gtgctgttaa tgtaggcggc gttaatcccc 2043301 gcttcttcta acgcatcaac ttgatccttc atcaaggaaa tcaacggtga aatgacgatc 2043361 gtcgtccctt caaacattaa tgccggaatc tgatagcaaa tcgatttgcc gcctcccgtc 2043421 ggcataatgc aggccgtatt ttgcctcgct tccgtcacca agcggatcgc ttcatcttgg 2043481 ccgctccgaa acttctcata accaaaataa tgagccagaa gggattgggc tctatgtaac 2043541 ataacgtgta aacctcgctt ttccttgaat ttctcccatc atatcataaa aaagcggcct 2043601 tcatttcttt cacacaaaaa tggaatattc actataccaa acctttttag ataaaataaa 2043661 aagccatttc cgaaaaggaa atggctttcg ctacgtcttg ccgtatgcaa gtaagaaagt 2043721 tttaaaccac cactcctcaa agtgggtgtt tgcagaaacg ttcctgtcgt cctctgcaat 2043781 ggaggcatga cattccggct tcgatataaa actccctatt acagcttaaa ggttaaaact 2043841 taattaacaa tacgcacaaa gtagcttctt taatatagta caccatcagg cgcttttaat 2043901 caagaggtca gaacaattgt ttagaaaaac tttttccagt gaataaaact gttttttctc 2043961 caaaatacct gacaattcga caaacaaaaa atatattaca ataaaaaaaa tagcctttat 2044021 tgctaaaagc gaatgattat tttcttctat attaatgtgt atatacaaaa agactcctat 2044081 ttgtaacgat aggagtcttg gctttattag aattttgcag caagatcttt tgcttcttgt 2044141 aaaccttttt caacgatttc ttgcgcttga tcaggtgctg cgttatgtcc ttcgatgaca 2044201 actgtgtgca agtcttgaac accccagaaa ccaagaactg ttttcatgaa gtttaatgac 2044261 atttcaagtg cagccattgg tccttctgag tagacaccgc cgcgagcgtt aagaagcgca 2044321 acttttttgc cgcccattaa accgactggt ccttcttgtg tgtatttgaa tgtaacgcct 2044381 gcgcgagaca gataatcaac ataagtatga agcactgctg gcactgtgaa gttccaaagc 2044441 gggaatgcga aaacaacttt gtcagctttt acaaactggt tcagatattt gtcagcaatt 2044501 gctgcttgtt ttttctcatc ttctgtcatt tccattcctt gacctgcttt aaatgttccg 2044561 ttaatcatat ctctgccaag gtaaggaagg ttttccttat gaagatctaa ttcaaccact 2044621 tcatcattag ggttgttttc tttataagca gctaagaaag cttcgtaaag tttagttgaa 2044681 acgccttctt cagctgtacg gtcgcttgat tttacaaata aaactgtaga catttgtatt 2044741 cctcccggta aactttttat atttacttac aaatagtatg ttactttctt ttttacgtaa 2044801 agtcaatcac tttattttga atatgagatt ttttttcaaa aaaagcaagt acatctaata 2044861 tcggtgtact tgcttggcat ttttacttcg aatcttgttc acgatccaag atttcatacg 2044921 tctgcgagct tttttgatca attgtttctt tgttggataa gtcttttacc tgttcatgaa 2044981 actctctttc ataagaagga gcatctgtct ccagatcatc ctccacatca gcttgggcct 2045041 caactgtcat tcttgcataa ggaacagctt caagtctttc gtaaggaatc tcttggccgg 2045101 ttttttcaca cacgccataa gttccgtctt tcatcttttg taatgcacgg ttgacctcct 2045161 ctaacagctc ccggtcaatc tctttcactg tttggtctgt catccggtct gtgacgagcg 2045221 tcccgtggtc tgccatatgg ttgtcaaccc cattggaaag ctcccccact tcttccgtca 2045281 ttgattctgt ttcctttttc tcgccagaca attctttttg catatcgagc aatttatgat 2045341 agagatgctg tgtttgttct tttgtcagtg ccatgtatat cctctccttt ctatcctgtt 2045401 tcccgttttg ccttctgtca aacatggaaa catcgatgga aagatgagct actgcctttt 2045461 tgaacggatc gtgaccgctg gcgtcgatgg tgcttcgggt tttcgttggc actttttgtc 2045521 cttctcttct ggcggtatat aataggttgc gcctatattt aatctgccgc tcagttcatc 2045581 aatggtcagc tcgccgaatt caagatgata gtcaactttt tcgacattca gcgtttcaat 2045641 atgtatatag gtttcttcag actcttgttt gctgctttgt ttttgtttct caatcactga 2045701 gagtctttct tcacattcac gcagtttgtc aagttctggt ttcaagcaat gcctgatcag 2045761 cgaccggaac atttttttca tgacatcacg accctttgca tactcctctt tcgtctacat 2045821 atataatgag gtatatccca tagaaaggag aggttttcat gcttccgact aacatcaata 2045881 tttctcatct caagactaac tcgataggca ccggctcatc ccttaccttt ggttctgcgg 2045941 agttaaggaa caggtgctct gctatcaaaa gaaataacgg ttttggggaa caaaatgcag 2046001 atggtattgt tatggtcatt ccgattgaat caattgatga ccgtgatgtg tcagatgcac 2046061 tcagtatgaa aatcaatcat caataacaat ggttttcgct tgaccttcgt ctttttgaat 2046121 agtgatgtat aggattccgt ctttaaaaat ggcattcatc tttccatgaa gatgatcgga 2046181 aagcggaatt ttcttttcaa aacttccgta tttcccttct ttttggcgaa agtcctgttc 2046241 attaaaatag gaaaagcgct gccccttcac cactaaataa tctccgtacg ataatatgtg 2046301 aacgtcttgt ttacggtagc ctggaagata aattaaaaac tgcacttccg caacggtatc 2046361 tacaatatcc atgctcggaa atgaagcatc tcctttccct cgctgatctt gctgcgcaaa 2046421 cggaaacgga gattggccat ttgtcataaa aggggttttt tggtcttcat caaatacctg 2046481 tttccaaaag tcaccgccgt acatctgctg tgcgaattcc atccactgct tcatcttttc 2046541 gaaatccatt tgaagccccc tgtcttaaca tactttataa ccgccagcat acaactatag 2046601 aaaggaggtt tgcctgtggt tcaaccaact ccgtatatca atattaatat tttcatgctg 2046661 aaaattaatt cctttgaaaa tgcttcagcg gttaacgtag gacaaaattt attggcagaa 2046721 tggcaaaatt cagataaaaa aaatcaaggc tacggacaga attttggaga tgcgagcgga 2046781 tttatgggca cgagaagcca tgtggatgac agagaccaaa ttgattctcc ggcctctttt 2046841 gaaagtgaag cggttaactc ctcaatcaaa aggaagtgat gagatgttct tttcaccctc 2046901 cgtcgtaaat gtcggcggat ttaaaatcaa tacgatggat cgaggttcct ctttaacact 2046961 cggtccgtat cagcaggtcg attacttttt atcagctaaa ataaatcaag ggtttggaga 2047021 agaaaatggc gactttactc ctcttgtcgt gccgatttca aatgtattag atgcagatct 2047081 tgttgattcg aactcagcga aaaacagtgt ggtgtaataa gaacagggcg cacatgccct 2047141 gttcttgttt ttatatataa aaaaagccta accatttttt gaacggctgg ctcatcaaat 2047201 attcagctgc acaaatgctt tgtcagcacc gcctgaacct cgcttaaatc ggtgtctttc 2047261 gcaaattcta attcgaaagt tttgcttctt gtcatcaata aaagcccagt gtccggatca 2047321 aacattcccg cttcttggat ggcaaagctt tcaattgttt tatatggaag aaatacacga 2047381 accttctttt tagaaaacat tttattgtca aagaaaatga tccgcttatt tgtaaagcaa 2047441 atttggtcca ctcggagctt ataaatcgat tcaattcttt ccccttcaac gagcaaagcc 2047501 tcaagcttct ttgcgtccgt tgatctgcta acagaaaaaa tacccaatga agaacccctc 2047561 tttctgcatt tatctatttg ttttatcatt cactacataa aaataagtcc tttatcccta 2047621 tataagaata cgacatagaa gacatttaaa ccattacgaa cagattacat ttttcaaatt 2047681 tttgatttgt tttttggctt ttaagctgtt gtcatcaagt aatacgcaca tatagagaaa 2047741 aaagtttcaa tattcagcaa tgtttttata aaaaagtggt ttttaatgat ttttttaatt 2047801 ttgttttata tttcctgttt taaccacaaa aaaaccgcag ctgagctgcg gttttatgta 2047861 tcgactgctt ttaacaaaat ctgtttgatg cttcaaggaa gcattacatc tcttcgaagt 2047921 attctttata atagccgccg actttattcg tattgtcgac cacaaagaga aactcctctg 2047981 tttcattttt tacttcatat tcttttcccg gcgttaaaac gcggtttacg atatattttt 2048041 ttgcgtttgt ctgcacacac tttacttttt taatggtttc tttttcaagc caatttttat 2048101 gaatcatgat gaaatctcct tttcttatct ataagcttat tgtagctttt ttcttttgta 2048161 aattgcaata tcggttattc attgattttg ccttgatttc tattatagaa tgtttgtata 2048221 cgcttacgtt tgaagcaact atcacagctt atttctgcta ttcaatccag gaatcaatgt 2048281 gctatcacca agaatctcag aacagaccat aaaaaatgac tggaggtttg ttacggatga 2048341 gttctttaac gatgcaagtg acgaaaaggc tggagacatt tttacaggga acaaagaagc 2048401 tttatattga cggaaagttt gttccgagtg cctcaggggc aacctttgac actccaaacc 2048461 cggcgaccgg cgaaaccttg atgacgctgt atgaagccca ggctgcggat gtggacaaag 2048521 ctgttaaagc tgcccggaaa gcctttgacc aaggtgaatg gagaacaatg tctccagctt 2048581 cgagaagcag actgatgtat aagctggcag acttaatgga agagcataaa actgagcttg 2048641 ctcagcttga aacacttgat aatgggaaac cgatcaatga aacgactaat ggagatattc 2048701 cgctggctat tgagcatatg cgctattacg ccggctggtg tacaaaaata acaggacaga 2048761 cgattccggt ttccggcgct tattttaatt atacgcgtca tgagcctgtc ggtgtcgtcg 2048821 gccagatcat tccatggaat ttcccgctcc tgatggcgat gtggaaaatg ggcgcggcac 2048881 ttgcaacagg ctgtacaatc gtcctcaaac cggctgaaca aacaccgctt tcagctcttt 2048941 atttggcaga attaattgac caagccggtt tccctgccgg tgtaatcaac atcatcccag 2049001 gattcggtga agatgcggga gaagcgctga cgaaccacga agcggttgat aaaattgcct 2049061 ttaccggttc cactgaaatc ggaaagaaaa tcatgtccac cgcagcgaaa agcattaagc 2049121 gtgtgacatt ggagctgggc ggaaaatcgc ctaatattct tctgccggat gcgaatttaa 2049181 aaaaagccat cccgggcgct ttaaacggtg tgatgtttaa ccagggccaa gtctgctgtg 2049241 cgggctcacg tgtcttcatt cataaagacc aatatgatga agttgttgat gaaatggcat 2049301 cctatgctga gtcactccgc caaggagcgg gacttcataa agatactcaa atcgggcctc 2049361 tcgtaagcaa ggaacagcat gagcgcgttc tttcctatat tcaaaaagga aaagatgaag 2049421 gagcaaaagc agtgaccggc ggaagctgtc cttttgaagc aggatatttt gtcgcaccga 2049481 ctgtgtttgc gaatgttgaa gacgaaatga ccatcgcaaa agaagaaatt ttcggacccg 2049541 tgctgactgc aattccgtac gaaacagtcg atgaagttat tgaacgggca aaccattcag 2049601 aatatgggct tgcagccgga ctatggacag agaacgtcaa gcaggctcac tatatcgcgg 2049661 accgacttca agccggaacc gtttgggtca actgctataa tgtgtttgac gcggcgtctc 2049721 catttggcgg ttataaacag tcaggactcg gacgagaaat gggatcatat gccttggata 2049781 attacacaga agtcaaaagt gtatgggtaa accttgaaga ctaacatgta tgtttaaaaa 2049841 actgctgcct gccagcagtt tttttctttc tgtaatggca gtaaaagacg ctgaatatat 2049901 atgcttctga aggagttgag cgtgatgggc acacttcagg agaaagtgag gcgttttcaa 2049961 aagaaaacca ttaccgagtt aagagacagg caaaatgctg atggttcatg gacattttgc 2050021 tttgaaggac caatcatgac aaattccttt tttattttgc tccttacctc actagatgaa 2050081 ggcgaaaatg aaaaagaact gatatcatcc cttgcagccg gcattcatgc aaaacagcag 2050141 ccagacggca catttatcaa ctatcccgat gaaacgcgcg gaaatctaac ggctaccgtc 2050201 caaggatatg tcgggatgct ggcttcagga tgttttcaca gaactgagcc gcacatgaag 2050261 aaagctgaac aatttatcat ctcacatggc ggtttgagac atgttcattt tatgacaaaa 2050321 tggatgcttg ccgcgaacgg gctttatcct tggcctgctt tgtatttacc attatcactc 2050381 atggcgctcc ccccaacatt gccgattcat ttctatcagt tcagctcata tgcccgtatt 2050441 cattttgctc ctatggctgt aacactcaat cagcgatttg tccttattaa ccgcaatatt 2050501 tcatctcttc accatctcga tccgcacatg acaaaaaatc ctttcacttg gcttcggtct 2050561 gatgctttcg aagaaagaga tctcacgtct attttgttac attggaaacg cgtttttcat 2050621 gcaccatttg cttttcagca gctgggccta cagacagcta aaacgtatat gctggaccgg 2050681 attgaaaaag atggaacatt atacagctat gcgagcgcaa ccatatatat ggtttacagc 2050741 cttctgtcac ttggtgtgtc acgctattct cctattatca ggagggcgat taccggcatt 2050801 aaatcactgg tgactaaatg caacgggatt ccttatctgg aaaactctac ttcaactgtt 2050861 tgggatacag ctttaataag ctatgccctt caaaaaaatg gtgtgaccga aacggatggc 2050921 tctgttacaa aagcagccga ctttttgcta gaacgccagc ataccaaaat agcagattgg 2050981 tctgtcaaaa atccaaattc agttcctggc ggctgggggt tttcaaacat taatacaaat 2051041 aaccctgact gtgacgacac tacagccgtt ttaaaggcga ttccccgcaa tcattctcct 2051101 gcagcatggg agcggggggt atcttggctt ttatcgatgc aaaacaatga cggcggattt 2051161 tctgctttcg aaaaaaatgt gaaccatcca ctgatccgcc ttctgccgct tgaatccgcc 2051221 gaggacgctg cagttgaccc ttcaaccgcc gacctcaccg gacgtgtact gcacttttta 2051281 ggcgagaaag ttggcttcac agaaaaacat caacatattc aacgcgcagt gaagtggctt 2051341 ttcgaacatc aggaacaaaa tgggtcttgg tacggcagat ggggtgtttg ctacatttac 2051401 ggcacttggg ctgctcttac tggtatgcat gcatgcgggg ttgaccgaaa gcatcccggt 2051461 atacaaaagg ctctgcgttg gctcaaatcc atacaaaatg atgacggaag ctggggagaa 2051521 tcctgcaaaa gcgccgaaat caaaacatat gtaccgcttc atagaggaac cattgtacaa 2051581 acggcctggg ctttagacgc tttgctcaca tatgaaaatt ccgaacatcc gtctgttgtg 2051641 aaaggcatgc aataccttac cgacagcagt tcgcatagcg ccgatagcct cgcgtatcca 2051701 gcagggatcg gattgccgaa gcaattttat attcgctatc acagttatcc atatgtattc 2051761 tctttgctgg ctgtcgggaa gtatttagat tctattgaaa aggagacagc aaatgaaacg 2051821 tgaatcttat caagcggaga tgttcaattg gtgtgaagcc ctgaaagatc agattcaaaa 2051881 gcgaggtcag cttgaccagt ttgaagatca aatcgacaag atgattgagg ctctggaaga 2051941 tgaccaaaca acagaagaag attggtataa acaggccgct gccctttatc gggatattac 2052001 agaatcagat gatacaagtg aaagacgcgc ttatgtccct atagggaaac acgtgctgcc 2052061 aaagcttcct tacaaatact ccgccttaga accttatata tcacgcgata ttatgatcct 2052121 tcatcataca aaacatcatc aaagctatgt cgatggcctg aacaaagcag aatcagagct 2052181 taaaaaagcg agagcgacaa agaattatga cttaatcact cattgggaaa gagagcttgc 2052241 gttccatgga gcaggccatt atttgcatag tattttttgg ttttctatgc atccaaacgg 2052301 aaaacggcgt cctacagggg cattgttcca aatgatagac ctttcatttg gaagctattc 2052361 cgcttttaaa gaacatttta cccaggcctc taaaaaagtg gaaggcgtcg gctgggccat 2052421 tctggtctgg gcacctcgat caggacggct ggagatttta acggcagaaa aacaccagct 2052481 ctttagccaa tgggatgtga tccccctttt accgcttgac gtatgggagc atgcctacta 2052541 tttgcaatac aaaaatgacc gggccagcta tgtcgatcac tggtggaatg tcgtggattg 2052601 gcgcgaggct gaaaaacgtt ttgagcaggc aaaagaagtc gtttggaagc tctattaaaa 2052661 aaagccccct ttcctcgggg gcttcgtgtg ttaaaaaata cctatcacat gcaaaaacac 2052721 gatgatgatg gcaacaggag atagatatcg aatgagcagc agccaaaccg caaaccactt 2052781 tcgtttgaga ttggaaccgc ttttcagctc gtcaaacaaa tcctgtttcg gtatttttag 2052841 cggaacaaaa atcgaaatca gtaacgcacc taacggcatt aaaatattgc tcacaagata 2052901 gtcagccgca tcaaaaatag acagatgaaa tatagtgacg tcacttaaga caccgtatga 2052961 taatgcagac ggcacaccga caataaaaat agcaataccg cctaaccaag cgaatcgttt 2053021 tctcttattg atatcgcctt tcgacagtac tgcgaccaaa atttccagca ttgaaaaagc 2053081 agatgtcaat gcagcaaata aaaatagaag taaaaatgct aataaaaaga taattccgaa 2053141 cggcatttga ttaaacacag tcggcagaac gttaaataac agaaccgggc cttggtctgg 2053201 cttgaggccg aatgaaaata cagctggaaa aatcgcaatt ccggccatta cagcaacaag 2053261 catgttcata acagttacag atacagcgga ctgtaccaga ttttcctgtt tctctaaata 2053321 agcgctatac gttaccatga cagatacacc gacacttaat aagaaaaagg attgtcccat 2053381 tgcatataaa atggtattgg catcaattgc agttaaatca ggcatgagga aaaatttgat 2053441 tccttccatc gcgccatcaa gtgtaaccga acgcaccatt aaaatgatga ataatagaaa 2053501 aagcgccggc attaatactt ggcttgcttt ttcaattccg ctgcttaccc cttttgcaac 2053561 aactaaaatt gttaccacca taaagagcag ctggcctcct acagccaaat aaggatttga 2053621 aatggtactt gcaaatatcg tatcaaaacc agatgtttgc gataaaccgc cagtgaagcc 2053681 ttttataata taaattaaaa tccatccgcc tacgacactg tagaaagata gaagaataaa 2053741 gcacgtcacc atgcctaaat aaccgatcca atgccacttc gttcctggag caagtgtttt 2053801 ataggactga acggcatctt tctgtgttct tctgcctatg atgaattcac ctaacaataa 2053861 aggcagtccg attaaaaccg taaataaaat aaaaataagt aaaaatgcgc ctcctccgct 2053921 ggttccggca acatatggga atttccatat cgcaccaagc ccgatagctg atcctgccgc 2053981 ggctaaaata aagccgagct tcgaagacca ttgatttgct tccttcaccg tatcactcct 2054041 atttgatcta accattataa aggttcattg taagaatatc ttcctatata gtcaagaaca 2054101 ttttaattag tttacatcat atatctatag acatctgcca aaaactaata ttgaattatt 2054161 cagaaaatta tttataataa gagaatgtta tgaaatttgt aagaatttct gctgaagttc 2054221 ttgataagtg tgttaggagt gtttttatgg acatcattag aaaaataagc cattttgcag 2054281 gacaaacctt tggcatatgg gtcattgttt ttgcagtgct gggattttct ttcccatctt 2054341 tatttacgtg gatcagttct tatattacga tttttctcgg cattatcatg tttgggatgg 2054401 gccttacact gcaagccgat gatttcaaag agctggtcag aaagccttgg caagttatta 2054461 ttggagtaat agctcagtat acgatcatgc cgctcgttgc tttcggcctc gcatttgggc 2054521 ttcatcttcc agctgaaatc gcagttggtg ttattcttgt cggctgctgt cccgggggaa 2054581 ctgcatctaa tgttatgaca ttcttagcaa aaggaaatac tgccctttct gttgcggtta 2054641 cgacaatttc taccttattg gcacctgttg taacaccgtt gttgattatg ctgtttgcca 2054701 aagaatggct tcctgtctcg ccggggtctt tgtttatctc aatcttacag gcggttttat 2054761 ttccgatcat tgcaggtctg attgtcaaaa tgtttttcag aaaacaagtg gcaaaagccg 2054821 tacatgccct tccgcttgtt tctgtcattg gcatcgttgc gattgtctca gctgtcgtca 2054881 gcggcaatcg ggaaaatctg cttcaatcgg ggttgctcat tttttcagtt gttatcctgc 2054941 ataacggtat cggttattta ctggggtttc tttgtgcaaa gcttttaaaa atggattacc 2055001 cgtctcaaaa agcgattgca atcgaagtcg gcatgcaaaa ctccgggctt ggggctgcac 2055061 ttgccacggc tcatttctca ccgctatctg ccgtaccaag cgcaatattc agtgtgtggc 2055121 ataacctttc aggttctatg cttgcaacat attggtcaaa aaaagtgaaa aagaagcaag 2055181 ctggatccaa aagcagcaat ctatcacttt aaatatgcat caaaaagggt acatcacttt 2055241 atcgtgatgt accctttttt attatccttc taataaaagc tgttcaggat cttccagtaa 2055301 atttttgatt gtcacgagga aaccaaccgc ttctttaccg tctacaattc ggtgatcata 2055361 agataaagcg atatacatca tcggacggtt ttcgaaacgc tcttcatcaa tggctacagg 2055421 gcgcagctga atcttatgca tgcccagtat accgacttgc gggctgttta aaattggagt 2055481 tgacatcaat gaaccgaaag tccctccgtt tgtaatcgtg aaggagcctc cctgaagctc 2055541 gctaagggtt aatttattgt ttcttgcttt tttcgcaagc tcgccgatct ctttttcgat 2055601 tcctgcaaat gtcaggcgat ccgcatcccg tacaaccgga acgacaagac cttcatcagc 2055661 agcaacagcg attccgatat cgtagaattt tttaacgatc aactcatcgc cttgaatttc 2055721 tgcattcaac agcggatatt ttttcaatgc agccacgacc gctttcgtga agaaagacat 2055781 aaagccgagc ttcacttcat tttgctcaaa aaattgatct ttgcggcgtt ttctgagatt 2055841 catgacagcc gtcatgtcca cttcattaaa tgtagtcagc atcgctgatg tttgctgtac 2055901 ctctacaagg cgttttgcaa tcgtttgtct gcggcgtgac attttttgca cttcaacagg 2055961 tttgtcaaag ctttgctgtg ctttttgagc ctgaggctgc tgcttttgct gaggagccgg 2056021 ttttgatgcc ggtttttcgt acgcttcgac atcctgcttg cgcactcttc caagcggatc 2056081 tccagttgga acttgagaca ggtcaattcc tttttctctc gcaagcttac gggccgacgg 2056141 agaagcgatc gttcttgatt ttgcttcaga ttgtgcttcc tcgctcacct cttgtgcagc 2056201 tggttcagcc tgtttctctt cttttacgct ttccttgctt tctgttttct ctgtaggagc 2056261 aggggcagaa ctttcacccg cgccttctga aatcgtaccg ataatttctc cgacctggac 2056321 ggtatcaccc gaatctttca atacctcttg aagtacaccc gattcttctg ctgtcaattc 2056381 aacattcact ttatccgttt ctagttcaag cagatattca ccctgttcta catagtcacc 2056441 aggctgcttt aaccattggg ctattgttcc ttctgagatt gattctgcta attcaggtac 2056501 cttaatttcc gccatttttt catttccccc ttagtttttg cgagtcaagc tatcagatac 2056561 aatacgttcc tgttcttttt tatgaactgt cggatctccc tctgcagggc tggatcgtct 2056621 tcttcgtcca atatattgaa cgcttactcc ctctggtgca atctctgtca aatacgggct 2056681 gatataaccc caagccccca tgttctgcgg ctcttcctgc acccaaacga tttctttcag 2056741 gttcggaagt tttgcaaata attctttgac tccttttgcc gggaatggat acagctgttc 2056801 gattctcgca atgtgaagcc actctttacc gtcttctaac ttattaaaat gatcgctaat 2056861 gtctatagac actttaccgc tggataatac aagtctggtt actttttcat agtcatgaga 2056921 aagtcccgac tgttcataaa caggctggaa gcggctttcg ctgagctcct gcacttccga 2056981 caccgtattt gggttgcgaa gaaggctctt cggcgtcata atgacgagcg gtctgatttc 2057041 ttcacgaagc agcattttag cctgtcttct taaaatatgg aaatactgtg ccgcgcttgt 2057101 caggttggca accgtccagt tgttttccgc tgcaagctgc aggaatcgct caattcttcc 2057161 gcttgagtgc tcaggcccct gtccctcgta accgtgcggg agcagcatga ctaatccgga 2057221 tttttggccc catttcgcgc gtccggcaga aataaattgg tcaaaataca cttgagcagc 2057281 gttggcaaaa tctccgtact gtgcttccca caaaacaagc gtttccggtg aatgcacgtt 2057341 atagccgtat tcaaaaccga gaaccgatcc ttcagacagc gggctgttat gaacagcaaa 2057401 tgatgtgctg cagtcagata agtgatgaag cggcacaaat tctttgcccg tctcactgtc 2057461 atgaagcaca aggtttcttt gggcgaacgt tccgcgctcg gaatcctgtc ctgttaaacg 2057521 aatcggtgtt ccgtctttca aaattgaagc aaacgcgagt gattctgcca aagaccattc 2057581 cacttttctg tcatcatcga acgccttggc gcgtctttct aaaatgcgct ttagcttgcc 2057641 gaaaacatta aatgactccg gccagttgat caattcgcca ttcagcttgc ggagcacatc 2057701 aaaatcaatc gaagtgtcca catctgggaa accgtttgat acaggctctg gaagttcaat 2057761 ttcacaagca gtgtgttcct ttttagacgg aactttctga tatgcatcct caatgcgctt 2057821 cgttaccgat ttttcgatgt tttgaacgac ttcctcggta accacgcctt cttttaccag 2057881 cttttcagcg aaaatttgtt tgacggtcgg atgctttctg acagcatcat acagcattgg 2057941 ctgagtggtt gacggttcat ccatttcgtt gtgtccatag cgtctgtacc cgatcaaatc 2058001 aatcagaaaa tccttgttga atgtttttcg gtattcgacc gcaaacttaa cagctgaaag 2058061 acaagcttca ggatcgtccg cattcacgtg aacaatcgga atttcataac ccttggccag 2058121 gtcgctggca tattttgtcg atctggattc agcgctttct gttgtgaatc cgatcatgtt 2058181 attggcgata atatgaatcg caccgcctac ttgataccct tttaaagagc ttaaattcaa 2058241 tgtttcagct acaattcctt ccccagggaa tgcagcgtct ccatggatta aaatggccag 2058301 cgattttgtt tcatcttgta ccgggtatcc gctttgtgtt cgcgtttcct gtgccgctct 2058361 tgtgctgcct tcaacaatcg gattgataaa ttccaagtgg ctcgggttgt tcgctaacgt 2058421 aatgcgcgct gattttgttt cagcgtcttg aagctcccga ttcgccccca aatggtattt 2058481 gacatccccc gtccatccgt agctgattcc aatggatccc tcagacggta caagatcttt 2058541 gttcggcgca tgctggaatt cagagaagat gatttcatac ggtttgccga gcacatgtgc 2058601 caagacattc aggcgtcccc tgtgcgccat cccgatgttg acacttgtcg tgcctgattt 2058661 gacagattgt gcaataatgt catcaagcac tggaacaaga gcgtccagac cctcaatgga 2058721 aaagcgcttc tgcccgacga atgtgcggtg caaaaactgc tcaaagccct ctacttctgt 2058781 caatctttcc agcacagctg acagcttttc agctgagttc ttctggaaca gctcgccaga 2058841 ttcaatcttt cttgtcagcc actcgcgctc tttgaagtca tgcacatggt caaattcaaa 2058901 agagatggtt cttttatacg tatttcgtaa atactgaatg gcttctaaac cgttcgaaat 2058961 gtttttagga gcgtctttgc agatgacaga cgcaggtatt gcttttattt cctcttctgt 2059021 tagcccgtaa tcggataatg gaaaaagttc gctctttttc tcatcctttc tgagcggatt 2059081 gacggaagcg ttcaaatggc cataggttcg gatatcttct gcaagtctga ctgcggatgc 2059141 gatcttttga atcagatcgg ctgtaacacg tcccttttct tttgttcccg aggcctcttt 2059201 tatatcgctt ggcggagcac cgagctcgtc gaacatttcc ttcaaatccg ggtcaatgct 2059261 gttcggatcc tgggtatact gatcgtaaag ctccagcgca tagccgaggt tcggaccgta 2059321 aaaatcttcc caattcattc gttgtttcat actattttga aacatttgaa tattaccccc 2059381 aacttaaata atcaagtgat tgattcacta tcttgaaata actttcgaac gctgtgtcca 2059441 aaattatgta ataaaaacgc ttccaacgat attttaccac tgtttgcaat ttgattctac 2059501 cttgattgtt cacaaaatag taaaaaacct ttataaaaaa caaaaaattt aatcattcga 2059561 aaaaacaaac gccaaaaagc ataggattaa gggctatcct atgcttttat gaagcagttt 2059621 tttcagcagc ggatacaaaa catccggtag ctgatcaaca tccgggacaa atatactgaa 2059681 ttttccgtac atatcctgga tcgtcttcat ttgcgattct tctatttctg agttggagag 2059741 aaaaacattt atcacttcta ttcctctttt tcgggcttcg ataaccgcct cacttgtatc 2059801 aacgatccca ttttgttcgt agccaaatgc ggccggctct ccatctgaga aaacaattaa 2059861 gaacttttgc gcctcgctgc gatgcagcat ttttttcgtc atctgcctaa ttgcgtaccc 2059921 gtcacggtta tcttcttctg gctcaagctg cataatggcc ggtccagaat cttgtcttaa 2059981 tgatgattgg aagggaataa ccgtattgaa atagtttggc tggctttttt cggttgcatc 2060041 atttgtgtcc tcccaaaaac cgacaatctg atgcggaacc gctaccgatt tcaacgcttc 2060101 gtgaaacagc acgattcctc gttttgtttc gtccattttg tcgaacatgc tggcggaaca 2060161 atcgaccagc aatgtaaaaa ctgcgtcgat ttctgaagat ggttcttgct ttttgtagaa 2060221 caggcgcgga tttcgctcag tgaagtaacg aagaagctta ttgttcagtc tcccggcatg 2060281 aaggtctgtt ctcggcaatg tttttttatg ctccagcgtt ttttgaatca tttgtttcaa 2060341 acgcttttga tacgattcaa tcgtttttgc ctgctgttta taagaaagct cttcttcact 2060401 ggttgccggc tgcggttctt tataaattgg aaatgcatat ttattttctt tgccgtcagc 2060461 catacccgct ccgttcggct ggtctttttg ggactccagc gcttccagct tggaatagtc 2060521 tttccgtttc gtttgtctgg ctgatccttg aacagagcca agggcctgat ctccatcgtc 2060581 gccttccctt gaagcatctt ttcctaaatc tgattttgcg ccgtgttcaa tatcaaattg 2060641 aaggaagctt ttagacggtg cttctgtttc ccggtgccat gtcggcattt cttcttcatg 2060701 gatatcctca tcaccgtctg attgttttgg aagcgtgatg tcatcactca gcttcggcgc 2060761 ttttttctct tcttcaaata acggctgttc tgcagctttt gcgtaatcaa gctcaggcaa 2060821 aaagaagtag gtgttcaaca tgtctttatc gagtacctct tcaagtccgt ccatgaggtc 2060881 ctcaacaatt ttcagaacct gccgtgtcga atctgcttca tacacacgca agagctgctg 2060941 ctcaataaac gggcgcatca gatcgatatc ttcacgcatg gatggaaggg tctcgagcgg 2061001 cgattccgct gtgagcttga aatagatcgc gcaaaagagc gcatcggtaa aaatgcttcg 2061061 ttccaaattt aaggtcagct gggttgagaa atgttttctg tacatgtctt ttcgcttcgc 2061121 aaatacatgt ttcgtacccg ggcgctcacg tttgatgcat tcttcgatcc taatgtcttc 2061181 aagcagcata aagagctgct tggcaaaact tttaaacgta agatggcgat ggatatcatt 2061241 caaaaagttc gcaaactcat gcagcgagct atatcttgtt ccgactgaac gcaggtagac 2061301 gtcgcttttc agacccgctt ccatgtcctc agctgccctg tctttccaaa agtggctcat 2061361 atagattttc ttttcaaatg gattgtaata ggactgaacg ccatactcca cttctaccgc 2061421 ttcactcttg gtgagtgttt tggccaaatc agtcagcatc ataaataaaa atgaatcaat 2061481 cgtgctgtcg ttaaatttga taaatttcat cgcagccccc tcattcaaac agagtttctg 2061541 caatatttcg gacagccgct ttttcccgat catcatcaag cttttctaca attccccgct 2061601 caatggcacg acgcggcgga atataagcag ctaaatcaca tgtatcgatt aaagctctga 2061661 tggatgccgc ttcttcagac acctgtccgt tattggcctg aacgatcaag tcagaggaaa 2061721 gcgtgataaa tctgtcaatc aatttctcgt ctttcaaggc tgactgagac atgagcactt 2061781 gtttcagcag ctcgccttta atataaggca catcaatgat gacaaaacgg tttttcaacg 2061841 cttcattcag aggaacagtt ccgacatagc cttcattgat ggctgcaatg actccgaaac 2061901 cgcttttagc ccgtatgacc tcgcctgtaa acggatttgt catcattttt ctgtaatcta 2061961 atacaccgtt tagaataggc agtgtttccg gcttcgccat attgatttca tctatataaa 2062021 gaaaatggcc ttccttcatt gcctttgtaa caggtcctga aacaaactcg attgttgcct 2062081 ggccagattg attttcaatc gttttataac cgaccaatgc ctcagcgtcc aagtcgactg 2062141 aacagttgac gctgtgcatc ggtttatgaa aatagctgga caatgtttct gccagctttg 2062201 tttttcctga acctgtaggc cctttcagca ggacattttt ccccatggct aatgcaataa 2062261 tggcgtcaaa taaaatggct tcatcctccg cctcatagcc tgatgttcct ataagcgatt 2062321 gaaactctgg ggaaataggc tgctctttat atgataaaag cttttgttgt atatcttccg 2062381 gcaatgttaa gtgctgtagt tgagttgtca tagacagatt ccctttccta ttcatattcc 2062441 attaacgagt atactaaaaa agcccctgta tgctcaatac aaaagggcct ggatgatatt 2062501 actgcttctc gttatttccc aaaagggctc cgcagacaat acgcgcaccg gaattgccgc 2062561 ttgggtttgt cagataatcg tccgcttgtt catgaataat aaatgcactt ccgtcctcgt 2062621 cgagaatatt tagtttactt ccttttttca gtgaagtgtc aggcgcattc attatgacat 2062681 ctacctttcc atcagcaccg acttcaaggt tcggcagatc tccggcatga tgccccatcg 2062741 gattattaaa gccgtgttct ttgttcagtg gattaaaggg accgcccgct gattcaaaat 2062801 ccggcctgac acaagaacct ttctcataaa tatgaaaacc gagagaagca cctggacgca 2062861 ggctgtttgc ggaaatatga atatcgaggc cttcatcatc tgattctttg atctctataa 2062921 aaccgactgc tttcccttca cgattgacca gctggacatg atgaccaaac gctgacgttt 2062981 caaccacttt tttttccggc acccggttag gagggtctgg aggttttttt tgtccgcatc 2063041 cggcaactcc cagtgccgtc agcatcatca acagcaagag acggtgcata ctgtctcccc 2063101 cttgtttttt ctaacagtgt ggtcaatcat tgtctggtat aaacaaaaaa gcctataaaa 2063161 ggctttttgt catactcatt tttaaaaata acttcttgcg cccaagtacc gctgtttcca 2063221 atacgaattg ctgagattgg aaatgtcgac gcccgatgag cttgcatgaa taaaatcacc 2063281 gccgcctaga taaatcccca tgtgagacgg gccggattta tatgtggtaa agaagacaaa 2063341 gtctcctact gacggctggc tgactttctg catgacattc caataccctg ccgtactcaa 2063401 tcttgatata gatgatacat tattaatgag gtaataaatg aagccgctgc aatcaaaacc 2063461 ggcaggcgtg tttccgcccc atcggtaagg cactccgaca tattttttcg cttccgttat 2063521 cattctgtca atcttcgaac ctatttgaat gtttgaccct gagttatctt ttggctttgt 2063581 tggctttgtc ggatttgaag gattagattt tgatgctccc gaaatagtca gaacctgccc 2063641 gatttgcaac acatccgatg ataaattgtt tttatcacgg atgctttgga cagtgactcc 2063701 gagccgattt gcaattttcc acagcgaatc gcctgctttt accttgtacg tcgttgtttt 2063761 tgagggattg gagtttgacg gctttttgga accgctgttt ccgttcttag gtgaactgct 2063821 tccttttatt ttgagcacct gtttaggata aagtgtatct gatgttaagc catttaaggt 2063881 ttttaattcg gctacagtca tatttaagct gtttgcgatt ttccacagtg agtcaccaag 2063941 cttgaccgta tatgtacttt ttgaagaacc tgaagaattg gaaccgctgt ttttctttga 2064001 tccatttgat ccgcttgaac tgcttgtccc tttgatctta agcttttgcc ccggacgaat 2064061 caggtcactg ctcaggctgt ttaagctttt aagctcagaa acactcattt tatgattttt 2064121 agcaatcatc catagggaat caccatatgc aactgtgtat gttgatgttt tgcttgaatt 2064181 agatggggat gtcgtgcttt ttttgctgct ttcaggaacc ttaagacttt gtccgacata 2064241 aagcaccgtt gatttcaatt tgttttcgga tttcagagct gatattgtcg tatcatactg 2064301 gcgggaaagt ttccaaagag agtcaccgct ttttactttt atcgtttttg cttccgcggg 2064361 tgctgcggcc atcgacgacc caacaactgc agaaacagcc aagccggcta caatcttctt 2064421 tttcattcat tcaacctcct aaactgtttt tttgcaaaaa cagctagtat tttgtttcca 2064481 aaaatggcac acaactgttt tatcgtcaat ttttcagcaa gttaaaccct tttcaaacat 2064541 ttggcgcagc attttcagca tcgttcgacc tttaaacctt caaataaaca tctaacattt 2064601 tacataagca cgatatgttt ttcgaaagtc taaggaacta tttaagcgag ggtaaaaatg 2064661 atggttttct attgatgaac gaagcagttt ctcctccttt cttgtctatt tttctaatca 2064721 attctctatc ggcgtgtcaa atcccttcct ctgcattctt atgaaatggc aaaaagcctg 2064781 ttctttcgat aagaacaggc ttttacacta tgcatttgct gattgagttt tttgttttac 2064841 agcttcaaga atgctgtcgg ctgctttttt agagccgcct gccgctttca gtgattgtcc 2064901 aatttctttt gccttttcag catacgaacg attattcatt acttcttgta tcgtctcttt 2064961 cagtaggctt tcagacaatt cttccttttt aattactttt cctgcgccga ctttttctac 2065021 ctgatctgcg acaacaaatt ggtcgcctcc catcggaatg acaacgagcg gggtttcaaa 2065081 atacaaacct tcacttgtgc tgttcattcc gccgtgggtc acaaataagc tggctctttt 2065141 caagatctca agctgaggga catacgggcg tacaatgaaa ttctccggaa tgtcgtttaa 2065201 ctcacttgtt ttaatatgct tgccgatgga aagcacaact ttaccgtcaa agtccttaca 2065261 cacttcaagg cattgattaa aaaactgctt ttgattatta aaaatggttc ccattgaaat 2065321 aaacagcacg ttttcattgt caatctgatc aaatgggaaa tcattgtttc cggctctttc 2065381 tgtaatggaa ggaccgacaa atacatatcg ctcgccaaat tgctcagcca gtggctgaaa 2065441 tccccttgat gtaaagacga ttgtcaagtc accatcagct aaaaaaacat caaatggctt 2065501 cttgatctct gcttgaaaat cagcatttaa cgtttctgca agctgctggt atgattcata 2065561 atgaggcgaa tcttcaagtg atcctttcat gtacgctccc atcatttcct tcgcaaattc 2065621 ctcattcatc gcaaaggttg tacacaatga aaatcttggc agcttcagca tgttggcaat 2065681 gactttaccc gcgagaagat ggtgatcata tatgacataa tcatacgatt catgtttgac 2065741 ttcctcataa atatgagtcg cgatatcctt acaggctttc aaaaaagcgc agagcatttc 2065801 tgtgaaatct ctttcttcat cgccggttgc gtttttcccg aagtaatctc ctctgaaatc 2065861 atgatactca cgaaactcta tatcaagagc tgtgattttt tctttatatt ccttcactgc 2065921 gtagtacgta atgttttctc cccgggattt cagctccttc atcacaccga tagagggatt 2065981 aatatgccct tcaccgggga aaccgatcat taatacatta gccatgcggc agcacccttc 2066041 ctttgagaat ttatgtaata ttttatacgg tactataaat gcataaacag gtaaagtatt 2066101 tcacttaatt aatattcatc atatataact tttctaccag tttatattcc ctgtcttcaa 2066161 gacaaaaagc attcagcttg aagcgaatgc tttaataaag atgcgaattc agtcattttg 2066221 tctcatgata ggattcttaa tcaggccctt tttattattt ttacgttctt ggtgaaatta 2066281 acggatataa tacaccgtct ttggcaaacg acatcttccc tgtttcctct gaaaccacga 2066341 gcaccagtgc atccgtatag cccgacatac caagagccgc ccggtgccgg gttcccaaat 2066401 ggatatccac ttccttcgtc gtcagcggga gcacattggc tgctgacacg agtttgtttt 2066461 ccctcactaa taaagcgccg tcatgaagag ggtttccggg aaaaaagatg ctttcaatta 2066521 atgaagagct gatctcggcg tgtagggagg tgcctttttg aataaaacgt tcaaccgggt 2066581 ctgctctttc aatcacaatt aaagctccat gcttatgttc cgataaggct ttaatcgcct 2066641 tggccagctc aataaatgcc ggcgtaaatt cctcaatgta tgattgcaaa taaaaggagg 2066701 atgcaatccc ctgcatgtcc tgaaaaacgt gccccaaatc atctaattca caaaggagac 2066761 actggtcttt ttcgtgaagc gttttcaaga ttagagatgc atcacctaat atttgctcta 2066821 agtacacctg tattttcccc ttgaacgcat tttctgatat ctgctcatag cgcatagcct 2066881 tcatctcctg tttaaatttc caacttttca cgaatgctta tcttattgat gcacattcta 2066941 ttggtaaagg agggatgtaa agaatggaaa tcgaaagaat cattcagtat atttgcacct 2067001 ttttaggcgt gatttcgctt tcttttattt atgcccaaat gtttagaaaa acgaaaccga 2067061 caaaaaaaga ataggcccgg cgttcattgc tttttataca taaaatgtta taatttctct 2067121 cgttatgaaa aagaaacgga gatcaatgta tgaaagaaac tcaaaacgcc cgggaaaaaa 2067181 tcaaacagct cttgcacatt ttaataccga tattcattac ccaagcgggg ctttctctga 2067241 tcacttttct agatactgtg atgtcaggga aagtcagccc cgctgattta gctggtgtcg 2067301 ccattggctc aagcctttgg acccctgttt acacaggact tgcaggtata ttaatggcgg 2067361 tcaccccgat tgtcgctcag ttattaggtg cagagaaaaa acagaagatt ccctttactg 2067421 ttttacaagc tgtatacgtg gccgcgcttc ttagcatcgc cgttttagtg attggatatg 2067481 ctgcagttga ccttattctt ggccgattga accttgatat tcacgtgcat cagattgcta 2067541 aacacttttt aggcttttta tcactgggaa ttttcccttt atttgtttac accgtgttga 2067601 gatcattcat cgactcatta ggaaaaacga gagtcaccat gatgattaca ctcagttctc 2067661 ttccaatcaa ttttgtattg aattatgtat ttatcttcgg gaagttcgga atgccggcac 2067721 ttggaggtgt aggcgcggga ctggcatccg cgttaactta ctggtgtata tgcatcatca 2067781 gttttttcat tattcataaa aacgcaccgt tttctgaata cgggattttt cttaccatgt 2067841 ataagttctc ttggaaagca tgcaaaaatt tgctcaaaat cgggctgcct attgggttcg 2067901 ccgtgttttt tgaaacgagc attttcgcag ctgtcacgct tctcatgagc cattttcata 2067961 cagtgaccat cgcgtcccac caggcagcca tgaattttgc gtctctttta tatatgctgc 2068021 cgcttagcgt gtccatggct ctaacaattg ttgtcggatt tgaagcgggt gcagcccgtt 2068081 ttaaggatgc acgctcatat agcttaatcg gcatcatgat ggcgatcggc ttttctttgt 2068141 tcactgccgc ctgtatcctt ttattcagag agcaaattgc gggcatgtac acttctgacc 2068201 ccgatgtgct ccggctgaca cagcactttt taatttatgc gctatttttt cagctttccg 2068261 atgctgttgc cgcaccgatc cagggagcac tcagagggta caaagatgtg aactatacgc 2068321 ttgcggccgc ttttgtctct tactgggtca ttggccttcc ggtcggttat atggtcggta 2068381 cgtttacaag cctcggtgca ttcggctatt ggattggatt aatagcggga ctcgccgccg 2068441 gagcagttgg gctgtttttc aggctggcaa aactgcaaaa acgttattcg caaaaacaac 2068501 acatttaaaa gaggtgatca atcatggcaa aaaacaaaaa attattcgag tatctttccc 2068561 agcatgcgga aaccatcagt tcaacatggt atgaaacaat cgaggagact gatcccaatt 2068621 ccatttatgc ctcaacagac cctgttgtca ttcacaattt aaagagccag aatcttgcct 2068681 ttaactataa aataaaccgt atttttatag atgatgagga cgtatacttg cctatactga 2068741 aagaatgggc ctttgaagtc acacaggatc aagagcattt aaaaactcct atccactata 2068801 ttattcggga gtttgtcaga gtgagagatt tatatgtttc ttatgtgaaa gaatttgtcc 2068861 atctcaatca gaatactgtg aaaagcgaag aagccgaaga cctgtatcac gcccttataa 2068921 aagcgtttga tcttgtgatt catattttta tagaagaaat gtacaaaaac acaagccttc 2068981 agcttcaggc ccaaaaagat atgattactg aattgagcgc tccggtcatc gtgctgtttc 2069041 acagcgtcgg actgctgcct ttaatcggag atattgatac agtccgcgcc aagctgatta 2069101 tggaaaacac actgcatcaa tgtgcgaaaa aaaaggtgac acaactgtat attgatttgt 2069161 caggagtagc tgtgattgat acgatggttg cccatcagct gttcagtctg attgaggcgc 2069221 ttcgtttaat cggtgtttct tcaactttgt ctggaatccg tccggaaatc gcgcaaacag 2069281 cggttcagct aggtttgtct ttcgaaggta tttccttgag atccactctc gcttcagcta 2069341 ttgcatcgga cttaaaatta aaaaaggtat aaggcttaag gccttatacc tttttgatta 2069401 atcattccat tgatacgtcc aatatatttc ttcttcaaac catgttgcca taacaggttc 2069461 attatttttc aatttctctt caagctctct gagcatgcct tctgtttgtg tgcggtgagc 2069521 tcttaacgca ttcattttaa tatcagctac ttctttgata tcaagtacga catcagcttc 2069581 gccgagaacc tcttctctgt tgcgggtaat ggccatgcag attgtacgcg gacggtcttc 2069641 tttctttttg cggtataatg cacggataac cgcttccccg catgcatcat ggtcagggtg 2069701 cacaccgtgt ccgggataaa atgtgacaat taaacttggt tttacatcat ctatgatctc 2069761 ttccatgata tcagctaaat actcatcgtc ttcaaattcg agcgttttgt cacggagtcc 2069821 aagcatccga aggtcattga tatccatttc tttgcaagcg ttgatgagct cttgttttct 2069881 tagcagcggc aacgtttccc gattcgcgaa aaatggatcg cccatatttc tgcccatttc 2069941 acctaaagtg gcgcaggcat acgtaacggg aatgtctttt tttctgttta aggcaatgag 2070001 gcctgccact ccatatgatt catcatcagg gtgaggcagg attactagta catgttcttt 2070061 cattattatt cacccttttc tttaaactgt gaacggtttt tcgctgattt gcagagaaat 2070121 agccagttta ccgcccggca ggtgtcccgc cattaataaa cggttttctt catctaccgt 2070181 gtattcagtc aagccttcag cataaatcca gccttcttct gttttcaagc caacgcggta 2070241 aggcccgttg cctttgattt ttgcctgatg ataagtgact tttgcattgc gaatatacgc 2070301 aacaaccgtc atgttctttt catttaagtg cgctgaataa gaacctgtgg tggtttctaa 2070361 atggatatat acagggcggt ccgcatatcg ttctaaagat gcttgcacat cttcttttat 2070421 gatcgctttc atgattgctc ccctctttct tcttttaaat actctgcacg ttctgtatgt 2070481 aatttgacca gctgatattt cacagccggt tcgagctgtg aattcacaat gcgctgaatc 2070541 gcggcaaaat atttttccag catcggtttt cggagtcttg gatgtgttcg tttatccaag 2070601 agctcaagat caatcgcctc tgctaccgct tctgcgtcat catgtgcgag agatcggtta 2070661 ttccaaagtg aagcataggc tttcactatc tctttatcat tgtccatcgt cttgctcctt 2070721 tatgtcttac atacatgaaa tgattataca taatatatgc atcagctgaa aagccaaagg 2070781 cctcaatggc tttttgacgc ccgtttccac ttcacttgtg aaaacgtaaa caagagcagc 2070841 gcagcccata tacagctgaa tgtaaaagcc ttcgagcttg aaaatggctc atggtaaaca 2070901 aacagcccga tcagcagggt aatggtcggc gcaatatatt gtaagatacc gacttgatac 2070961 agtggcagcc gtttcgctcc ttccgcaaac aataagagcg gcaaagccgt aaacacaccg 2071021 gccaaaaaga gaagcagcca cgtccctccg ctttctgcac ccgctggctg aacatgtccg 2071081 ctgaacagca aataccccaa tgcaatgggc ataatcatga atgtttccag cgttaaaccg 2071141 atggcgctcg gcaggcttgt tctttttttg cttaacccgt acagcccaaa gctgaatgcg 2071201 agcagaagcg caacataagg aatggagccg tattggaacg ccgagatgat gacaccggct 2071261 gccgcaatcg aaacggccac taattgcagg cgattcagtt tttcctttaa aaataaaatc 2071321 ccaaggagca ctgatacaag cggattaatg taatagccaa gactagcctc aagcaaaaag 2071381 ccatggttga cagcccatat gtatacaaac cagttgatcg aaatcaggat agaagcaaga 2071441 aataaagaga ggatccctcc gttctttttc agagagcgca actcctgcca tcctattttc 2071501 cattgccgca agaaaaaaag tacgatacac ataaaaacaa aagaccatat aatacgatga 2071561 gccaaaatat caagagccgg cagctgttcg agaagcttcc aatagagcgg aaacaggccc 2071621 cacatgataa atgaaacggc tgtgtaaata acgccttttt ttgtttctgc atgttgcatt 2071681 gatatccctg cctttcttta gagcatctta tattatatca cgtgaaagat ctggtgggca 2071741 tatactattt tgtccgtgaa gaaaggatgt gaagacaatg tttgagtgga acaagtactt 2071801 tcctttccac aatcaatttt ctaaagaagc attaaaaaaa gctgatccga aagaagttga 2071861 aacgtatgtc aatcgtgtga tggaaagtgt gttcggcagt gattatgcgg ctcaatttcc 2071921 tttccgcgat cctctccccc aaaaagaaca tcccgccaaa cctgatgcaa aacctgatgt 2071981 caaacctgat attgatatat tcgaaacagc agaccatgtg tttgtaaagg tgccaatcag 2072041 cgaagaatgg ctggaacaag tgagaatcaa acacacatct cacgaattat ggttggaaaa 2072101 cctcccaaga gcagatcatc cgaaaaaagt aaaccttcct tgtttagtca aacgcaaagg 2072161 aacaaaagcc gtctataagg atggccttct ggaagtcatg tttcaaaagc agcaagacta 2072221 caatatgtcc gaggtagaaa tcatccgata aaaaacggcc tgcaatcgat gcaggccgtt 2072281 ttttattaat agaagccggg atatcccccg tatggcacgc cggcaccaaa accgtacggt 2072341 ccgcctccat atccataagg gccaggagga taggcatagg gacgagaata gttaaacagc 2072401 gcactcccga gaaaaccgcc taataaaccg ccgactagag gagcgccaaa caaaaaagga 2072461 ctacgcgccg gatatccggc tggacctggg attccgcgta aatacgaatg atgagggtac 2072521 atgatttttt cctcctttat gtctgcctat acgtaaagta ttcagcaagg aagaaaaacg 2072581 attgggctac ggactgtcta tgattgttac atcacaagcc ctgccaataa cacacagccg 2072641 agccctgtaa ccgaaagaac tgttgtaagc agcgtccagg tttgaaatgt ttctttcatg 2072701 ctcaagccga aaaattcctt taccatccaa aatcctgcat catttacatg acacgcaatg 2072761 acactgccgg ctcctgttgc aagcaccatt aacgcagggt ttacactgcc agcctccata 2072821 agcggagctg ccattcccgc tgtggtaagc gcagccacgg tagcagagcc tagacacaga 2072881 cgcagaaccg cggcgatggt ccatgcaacg aatagcggcg acatgtttgt ttgacggaaa 2072941 aaatcagcga cataatcgcc gactccgccg tcaatcagca cctgtttaaa cgctcctccc 2073001 cctcctatga tgagcagcat catcgcaatt tgcgaaattg attctgaaat agatctgccg 2073061 atttcctgca tagatatttt acgggcatat cccatcgtat agagtgcaag caacagcgaa 2073121 atgagcattg ccgttcccgg agtgccgata aattctataa tgtcttttcc ttttgaatgt 2073181 tcactcaata ataaagaaaa aattgttgcc attgccataa agataaccgg gaataaagac 2073241 gtgacagcac tgatcgcaaa gcccggtgtt tcatccagct gaaattcttt ccttggtcct 2073301 aaccccgata ggtttccatg cttttgatac gcaccaggaa accgtttcat cgcaaattta 2073361 ttaaataaag gcccggcaat cacagttgtc ggaacagcga tgatgattcc aaaaagcagc 2073421 acctggccaa tatgggcacc atatgcaact gagatagcag ttggagcagg atgcgggggc 2073481 aaaaatccgt gagtaacatt taaggcggcg gccatcggga ttcccagata cagaaaaggc 2073541 atttttaatt ctttagcaat cgcgtaaaca atcggtatca acagaacaag accgacttca 2073601 aaaaataggg caatcccgat gataaaagag gcaaccacaa ccgccgcctg tattcgtttc 2073661 ctcccgaatt tgtcaatcag cgtaatggcg atccggtagc cgcccccagc atctgagaca 2073721 agcctcccaa gcatcgcgcc aagtccaaac actaaagcta aatgccccag ctgcccgcca 2073781 attccagtct caattgaaag aacaatttta ttgatatcca ttccaagtcc gatggctact 2073841 aaaaatgaaa cgacaatcag tgagacaaag gtatttaatt ttactttaat aatgagaaat 2073901 aacagaatca gcactccgac agctacaatt aaaatcggca tggtacccct ccaaaagtgt 2073961 tttatatgat tctcgcgaca atgttttggc gcttttcatg cctagatgaa cagaaagcgc 2074021 tttcattaat aactaaaaac gtcttggtta tatgattgtt atcttttgat caactaatat 2074081 gttcatacta atctcctaat caatgactgt caatcgtttt tatgagcttg tctcgattac 2074141 ctaccgccta acccaatgat ttattagtta tatgttgatt aacttttggt tatatgttat 2074201 gttttttaaa gttgactgcc aatcattata tctctccatt gtctggaagc aaatgagaca 2074261 atatgagaac agacggataa caacttcata agaggaggag tacacatgcc attattgcgt 2074321 tttgatgtaa ttgagggccg tgatgaaaaa tcgctgcaat tgttattaga tactgctcac 2074381 caagcgatgg ttgaagcatt tggtgttccg gaaagagacc gttatcaaat tgtccatcag 2074441 catcccgcaa acgagcttat aatccaggat gcgggattag ggtttcagag aaccaaggat 2074501 atggtcatca ttagcatgac aagcaaagca agaaccgaaa gccaaaagga aaaattgtat 2074561 gctctgcttg ctgaaaggct agaaaaaaaa tgcgaaattt cccctgacga cctcatggta 2074621 tctattactg agaatggtga cgcagactgg agtttcggtc tcggtgaggc gcaatttttg 2074681 aatggaaaac tataagattt cgtctcccca caaaaaaaag aagagagagc tccaaagaag 2074741 ctctctcttt tttcataaat gcggaagtca tcagtataga agcatccagc aatacgaaaa 2074801 acctggatct ccttttatat ccggtttaaa tgccaattgg aagctgactg ggttttggct 2074861 gaaaatataa aattttgctg atttgcataa taagatacat cataatcccc atttacaata 2074921 ggttggatgt tatagcttat tgatcatttc ctattttata tatccccttc atatgcacat 2074981 gacatttttg ccaatccgga aatatcagtc tgacaaatat aaaaagtcat gtaaacgggt 2075041 gtgaaccgta cttacatgac tcaccatgga aacaaaggct ctttttcagg tgccgctttc 2075101 cttatttctc ttcttcacac actgtgtcac caggctcgca aaattgatcg gcccatgcct 2075161 gcatttcttg aaatacagct tgaagcgctg ttcctttttc agtcagcgtg tagatgactt 2075221 tgaccggcgt ttcagggaga acctgccgtt cgacaatctc gttttgttca agctccttca 2075281 agcgctctgc caacattttt tggctgatca tcggtattgt ttccgttatc tctttaaacc 2075341 gtttcggccc atccattagc acatggatga tcagaccgtt ccatcgtttt cccagcaatg 2075401 agaatgcgga ttccatttta gggcacatcg tatttcccat aagtcttcat cccttcatct 2075461 attgattgac atgtattcaa tgatccatta caataatctt tcaagttaca tttagtaagc 2075521 ttctaacttt tctattatca taccacgttt atccgaagga ggaaacacta tgacgaatac 2075581 tctggatgtt ttaaaagcac gtgcatctgt aaaggaatat gatacaaatg ccccgatctc 2075641 taaggaggag ctgactgagc tattagacct tgccactaaa gcgccttctg cttggaacct 2075701 tcagcattgg cattttacag tattccacag cgatgaatca aaagcggagc ttcttcctgt 2075761 agcgtataat caaaaacaaa tcgttgagtc ttctgctgtt gttgccattt taggcgattt 2075821 aaaggcaaat gaaaacggtg aagaagttta tgctgaatta gcaagccaag gctatattac 2075881 ggatgaaatc aaacaaacat tgctcggcca aatcaacggt gcttaccaaa gcgagcaatt 2075941 cgcacgtgat tccgctttct taaatgcttc tttagctgct atgcagctta tgattgccgc 2076001 aaaagcaaaa ggttatgaca cttgcgcaat cggcggattt aacaaagagc agttccaaaa 2076061 gcaatttgat atcagtgagc gctatgttcc ggttatgctt atttcaatcg gcaaagcagt 2076121 gaagcctgcg catcaaagca accgtctgcc gctttcaaaa gtatcaactt ggctgtaagg 2076181 atatgaaaaa ccttagtccg aaatccggac taaggttttt ttatacaatc gcctctttgt 2076241 accattcacg agcctgttca gcttcatgct gagtcagctg atggcccccg tcctgccagt 2076301 aaacggaggc tgatgccccg ctgtcacgca aatagcggta aagctcttct gattcttcct 2076361 tcgtgcaaag aggatcgtat ttcccggcac cgataaaaac agggagcccc gccatatcag 2076421 gcagctcgat accccgaatc ggaaccattg gatgatgcag aatagcccct tttaacacat 2076481 ctttataatg aaaaagcagg cttgccgcaa tgtttgcgcc gtttgaataa ccgactgcaa 2076541 tcactcggcc gcgattaaac tgatgcgttt ctgcagcctc gtcgataaaa tctttcaatt 2076601 ctcttgtccg caccacaaga tccttttcat caaaaactcc ttcactcaga cgtttgaaaa 2076661 atcgcggcat tccattttca agcaccgatc ctctgacacc aagcaaatgg gcatcagggt 2076721 ctataaaccg ccccaatgaa agcagatcgt gttcattacc acccgtgcca tgcaacagca 2076781 aaagtacgtt gtcagatgtt cctttctcat aaatatgctt cattataaat tccccctttt 2076841 aaagttcagg taaaatgtct gtaatttgtt gtctatgttt ctccagccat tcaggcagtt 2076901 ttaaggaagt ccctagctca gcaaacgttt catctgtcat aaagcccggt tcatctgtgg 2076961 caatttcaaa taagataccg cctttctccc taaaataaac tgatgtaaag tattccctgt 2077021 cgagaatttc tgacgaaggc agatggtttt cagcaataat cggcagccat ttcgcctgtt 2077081 cctttttctt agtccgaaac gctacatggt gtaccgtacc atatcctccg actcctcttt 2077141 tttcaggatg taaatggaca tcaatgacac cgccgaccgc cgctgaagat gccagtctga 2077201 caatctggtc ttcttcggcc actttggtgt atccaaagct ttccgttaac aattgtatgg 2077261 tcgcctgcgg gtcgtaggaa tatagcagca cacctttcat tcccgtaatt gcttcatttg 2077321 ttgtgatccc gtcaggcgtc cactcgcttt tgccgctttt cgcatcctcc atgatcgcca 2077381 gcggaaggtc ttctgtatca tcaaaaataa gacctttttc accaaacaac gttttttcct 2077441 ctaggctcag cccgcttttc tcaagacgtt ccttccaaaa agacagggag cctgagggaa 2077501 ctgaaaagta cacccggccc gcttggcctt ttcctaccgt tccctgtccg cttccttgga 2077561 acggaaaaaa ggtcattatt gtaccgggat ctccgttttg attcccaaag taaaaatgat 2077621 acgttccggg atcatcaaag tttactgttt ttttaacgag cctgagccca agcacttctg 2077681 tataaaatcg caagttttct tgcggatctc tggcgaatgc tgtgacatgg tgcaatcctt 2077741 ctgttttcat tttctcactc ctatttatct cgatttcaag atatttatta ttttaaacct 2077801 ttattgaaaa ggatgcaaac catgtgtttt gattaaataa ttgaaaaaat catttttttc 2077861 taataattat cttgtgatct tttcttacaa ctgctattat agtgagcatt atcatgtttc 2077921 aggaggaaag taaatggtta aaaaagcact tattgttatt ctcattcttt tgccattcgt 2077981 tcagctcgcg cttttgccgc ttgtgaatcg aatagaaccg attatgttcg gcctgccgtt 2078041 tttccacttt tggctgctgc tgtggattat tgttacgccg ttatgctcgt ttggcattta 2078101 tcagatgcaa aaaaaagatg gaggacttga ataatgcaag ggaatctgac tgcacttctc 2078161 attactgcta ttattgtttt aaccgttgtc tgtatcggct ttctcgccgg aagagacaaa 2078221 tcctcacgta cttctgtgga agaatggtct gtcggcggca gacgcttcgg cggtcttctc 2078281 gtctggtttt tagtaggcgc tgacctttat acggcctata ctttcttagg gttgaccagt 2078341 actgctttta caggcggaag tgttgcattt ttcgccattc cttattctgt gttggcctac 2078401 tttatcgcct acttcttctt gccaaaactt tggaaagttg cgaaaattca taaattaaca 2078461 acactcgcgg attatgcccg ggaacgtttt aacagtaagc ttttggcaag cctcgttgcc 2078521 atcgttgggg tactcatgct tattccgtac atatgccttc agctgagcgg cattcaagac 2078581 acgcttcagg ttgccggcac tggctatatt aacgtaaaat tcgttgtgat catttcattt 2078641 attcttgttg ctctttacac attcttcagc gggattaaag ggcccacata tacagccatc 2078701 attaaggaca ttttagtatg ggtcattatg ctgtttatgg tggtgtccct ccctctcatt 2078761 cattttaacg gctggacgcc aatgattgac acgttagtga aggaagcgcc gcaaatgctg 2078821 acgataccgt cagaagggcc aaaaggcatt ccttggttta tcacagcatc tattgtttcc 2078881 gctctggcac tttttatgtg ggcacatgcc gctacaggtg ttttcacggc gaaaagcgct 2078941 gatgcagtaa gaaaaaacag catgtttttg ccgctttata atatcgtgtt aattttggtt 2079001 atttttcttg gctttatcgc ctttcttgtt ctgccggaag atacaaatcc aaggctggcg 2079061 ctgctgcatt tgattcaaac atcttacggc ggcgtggcac aaggctttgc atatgccact 2079121 atcgctcttg cttcattaat accttgttcc attatggcaa tcggcgcatc gaatttattc 2079181 gccaacaacc tataccggga tttgattcat ccgaatgtgt cgcaaagcaa gctgactctt 2079241 gtcacacgtt caatggtgtt tgttgtcatc ggtcttgcgc tgctgtttgg aatgctgttc 2079301 ccgactgcct tagtgacact tcagctatta ggtgtatccg gtatggtgca aatcttccct 2079361 gcgattgctg tcagcctgtt ctggaaaaac caaacgaaag aagcaacggt tatcggatta 2079421 ttagccggcc tagcggtaac gtttattgtg tatatcactc aatccgcaca tggcatttat 2079481 gaaggattct ggggattggc cgccaacatg atcgctgtgg tcatcctgaa tccgctgttc 2079541 gttaaaaacg cgggatccaa tcctgtcatt gaaggtttat ttggcaaaaa acaagacgct 2079601 aatccaaatc aaaagggcgc ataaaaaaac catacgcggc agccgcgtat ggtttttttt 2079661 acatttcttt tttcagtgtt tcaattgcct tttccatttg cgtatcatta tcagacagct 2079721 tcttttgaag ttctatcatt aatttcgttg ttgtatcgcc agtcagtatg cctgtttcat 2079781 tcagcttctc ttttttctgg aactgtttga cgacagatac aaaatcctgg tcatacatac 2079841 tgttaacctt taccttgtaa ccaagtgctt tgagcatttt ctgagccact ttgacgtttg 2079901 tgcctgtatc acctgatttg tacgttttat ctgcgtccaa atacggcagc ttcgcgtaat 2079961 caggcagctc tgctttcact tgaggcttga tgcctttttt gtgaatccat tcgccatcag 2080021 cagtcagcca tttggcaact gtcagtttga cggtagagcc atcatcatat tcttttgccg 2080081 tttgtactgt acctttgccg aatgtcgtct cgccgattaa cggtacgttt gacgattcat 2080141 gaagggcagc ggccataatt tcggctgcgc ttgctgtacc gtcatttact aaaacgacgg 2080201 tcggcttggt cactttccgt tctttttcgg ccttcatgac ttcttttgaa ccgtttttgt 2080261 attcaacctg catgatgttt ttccctttat caatgaacag gttgctcatc gtaatcgcct 2080321 gttccattaa gccgcccggg ttgcctctca agtctaaaat atagcctttg gcgccttttt 2080381 tctctaaact gtcaatcgca tctgtcagct ctttagctgt tgtttcagag aaagaagtga 2080441 tttgaatttc tccgatgttg ttgtctttca tctctgaata gacagtctct acaggaatgg 2080501 tatcgcgctt aatggaaaga tcgatattcc ccactcccgc tctgttcagt tcaagcttca 2080561 cctttgtgcc ctttttgcct cggattaaag cgacggcttc atttacattc atgcctttta 2080621 cgctttttcc atttacctta atgatttggt ccctcggttt gataccggct ttttcagcag 2080681 gtgaaccttt aattggggat acaataagga tttctccgtc tttctcctct acttgggctc 2080741 cgattccttc aaaagatgct gaaatcgtct cgtcgaatga tttcgcttgc tcttgatcca 2080801 tatatgtaga atacggatca tccagtgatt gaatcattcc tttaattgct ccgtctacta 2080861 atttgtcatc atctgttttt tggtaataat cacttttgat ttgctcatac gctttattta 2080921 atttgtcgaa cttgctgtct cctgtgcttg ctgatttttg gcccaggata ctggaattgc 2080981 ccgtaataaa taaagtaagc gccgaagcga caactgcagt gatcagcaca ataaaaaaca 2081041 gttttaattg ccgtttcaat taaacaccac ctttttcttc ttacattatt atcatggacg 2081101 aattcttatt cgtcaactcg gagcagaaat gaaagagaaa cgcccttctt ttgcttttca 2081161 taaacctatg tctttatacg acatatgata aggaaaaagg aggattcgat attgagccga 2081221 tatttagaaa tgctgtcctt attcggtgtc gcaggggcgc acccaggcgg gctggctttt 2081281 tcaaaagcgg tcttgcaaaa ggctgcaccc tctccggatc agccgattct tgatgccgga 2081341 tgcggaacag ggcaaacggc ggcttattta ggacatttgc tgtatcctgt aacagtcgtt 2081401 gataaagatc ctattatgct tgagaaagcg aaaaaaagat ttgcgaatga agggcttgcc 2081461 atccctgcat atcaggcgga gctggaacat ctcccgtttt cttctgagtc cttttcctgc 2081521 gtcctgtcag aatcggtcct cagtttttca cgcctgacat cctctcttca agaaatttca 2081581 agagttttaa aacccagcgg gatgctgatt ggtatcgaag ctgctttaaa aaaaccaatg 2081641 ccccctgcag aaaagaagca aatgatggat ttttacggat ttacttgctt acatgaagaa 2081701 agcgaatggc ataaactcct aagatcctat ggctttcaaa aaacagaagc gatgtcactt 2081761 cttccggaag acatggaatt tgaaccaacc acagaaatgg atttatcgca aacgattgat 2081821 cccatctatt acgatacgct tcaaacacat tatcagctca tgcagttata tagtgagtac 2081881 atgggtcatt gtatttttat cgcgtacaag taaaacggcg tatcgccccc tgttttcgtc 2081941 caaccttttt ttcctatcta tcatatgctg atagaaagtc aggataggag gggaacaata 2082001 ttggagagat attatcatct ttgcaaaaac catcaaggta aagtcgtcag aattacagag 2082061 agaggcggga gagttcacgt cggcagaatt acccgtgtaa caagagacag agtttttata 2082121 gctccggtcg gcggagggcc aagaggtttc ggttacggat attggggcgg ttattgggga 2082181 tatggagcgg cttacgggat ttccctcggt ttaattgcag gagtggctct ggctggttta 2082241 ttcttctggt aagcatagaa caaatgctag attcaccaga cacaatgaag cccgcttatc 2082301 tagtgtaagc gggcttttca ttttaaattt tcttcacttt ttcaaagtac tcttcaagcg 2082361 ttaaatcatt atcttggatg acctttgcgg cttttttgcc tacatagcgc agatgccatg 2082421 gctcatattc atatttcgtg atatcttctt tatttttcgg atagcgaata ataaagccat 2082481 atttataagc attgtcctgc acccatttcc cgtctgccgt gcttccgaac gcttcattta 2082541 gctcaaagcc attgctccgg ctcgaaatgt ccatcgcaag gcctgtttga tgctcgcttt 2082601 cacccgggta agcgaccgct tcctttgcct tcctttcccc ttttaggctt acttcattgt 2082661 caaaaatgac tttctgtctg tcatacgaac ggtaccctga gacagctgcc agttcatagc 2082721 cttccttttt ggcagcatcg aacattgttt ttaatgcgtc ggccgcttct tttctgatgt 2082781 aacgtttttg aatcttttct tcaaaagaaa actctacatc aggtatgaca agatcgctag 2082841 gttcatagtt tccgggcagt gcatattgtt tattgacaag cgcgagtata ttttctggat 2082901 tttgaatggt ttccagacca tcgacttttt taatatcatt gaaatactgg ctttccaatg 2082961 aaaactcact gttttgagtg tttgattttt tgctgtcagc tgttttttgt tctgtttgct 2083021 ttgtttctgc tgtggttttc gtatcctttt gagcatctcc gttcgacatg ctgcagccgg 2083081 ctccgactat tgccgttaca ctcagagcgg cagccagtga gaaccattta ccggactttt 2083141 tcatattaca ttaccttcct tttatcaatc gtttccgcat gcataaagaa gaggctgccg 2083201 gcacccagca cgcctcttga tatattttat tgtgatacgg aatgtaaagc cacttctatc 2083261 atatcatgaa atgtcgtttg acgctcttcc gctgtcgttt cttctcctgt taatacgtga 2083321 tcactcacgg tgagaattga cagggctttt cttccgtgct tcgctgctaa tgtatacaat 2083381 gcagttgttt ccatttcaac gccaagcaca ccgtattttg caagtttttc aatttgcgaa 2083441 tcgtcattgt agaactggtc agctgtaaat acgcttccta cagtcaccgg cacaccttta 2083501 tcctttgcgg catcataggc attttttaaa agctcgaaat ctgcgcaagg cgcaaaatca 2083561 acgcttccga aagcaactct gttcatttgt gaatcagttg aggaggtcat cgccaaaatg 2083621 acgtctcgca ctttgacatc tttacgaata gcgccgcagg aaccgactct tattagattt 2083681 tgcacatcgt agctttgaat taattcattc acataaattg aaatagacgg aactcccatt 2083741 cccgtgcctt gtactgagat ttttttacct ttatatgtac ccgtaaatcc atacatgcct 2083801 ctgacttcat tgtagcattc tacattttca agatacgttt ctgcaataaa ttttgctctg 2083861 agaggatctc ccggcaaaag cacagtatcc gcaatttgtc ctttttcagc acctatatgt 2083921 acactcatct catatcctcc tgtaaatcta aattatcatc cagcccgtcc attttacaac 2083981 gaatgtcatg atgaaacaaa cttcagcatt gattataaag gaatatatcg aaaaaagaaa 2084041 tgttcgagga tctgttaggc acttcctcag aaaaacggat aatcggggtg ttaatttgaa 2084101 aacctaaccg caggaaggag gggtgggaca tgggtaaaaa acatcgtaac cggatcaccg 2084161 gccaaaaaaa gaacaatcat atacctgaaa aagatatcat tgcagctgaa gaagcacacg 2084221 ggaaagaata ttccgctgcc aaacgcaagc cttaaaactg cagaaaactg cgggtttccg 2084281 cagttttctt ttcattatgt cgtttgtaca atcagacgat tgattttcct ccagccggcg 2084341 ggaagcagtt gataatatgt tttccctttt ctgccttcat caatcaggat cacgtcccct 2084401 gtggccatga atcttgcatc ataatcactc ggaacagtgt cgaatacatt aaacaaagag 2084461 aatgctcttt tcagcacgtc ttgatgatcg ctcccgttca gttcagttcg atagacggct 2084521 ctgtagccct ttttttcgcc aaaccggggt gtctgaaata ttgtcacgtc ataggaacaa 2084581 gacttctttt taaacacgga taacatcatc aagatcccct cccttttatt tctttaacat 2084641 attggcgttt ttgctgtgtt ttcctctctc tatttttgtc gaaaccgctt aatcttttcg 2084701 tcaaaacctt ttactaggaa aaacagaagc aagccgaggc taaagcctcc taacacgtct 2084761 gtcacaaaat gaacccccag atacactctg cttatgccga ctaaaacagc aattacaccg 2084821 gctatgatat ataccatttt tttatgctta gacaaaaacg ggagatgttt cactaaaaag 2084881 taagcaataa caggatagac acaagcagca ttcatggaat ggccgctcgg aaaactgaag 2084941 gatgattcat gaaccagcgg tgcaaaatca ggcctcactc tttcgatcca ttcttttaag 2085001 actttgttta acagccgatc tgtgccgaat actaagagca tcaacaggcc gtcccatgtt 2085061 tttctgtaga aaaacatgcc tgctccaatg atgacaatta gagggagcag aaaagaagaa 2085121 gcaccaagat gcgtgatccc cgtcatgact tcattaagcc atggctgacg gatcaaaaca 2085181 gctgccttgc ttattgcttc atctgcagat tgaacagcat ttgtatgaat ggccgcagct 2085241 agaattaaaa agaaaagaaa caaactaacg ggcttgtaca attttaacca cctcaatttt 2085301 cacagaagtc atagaacatg aataataaaa ccggagctga ccgctccggt tttaagcctc 2085361 actcatcttc atccagctct tcatctatca tacatttttc tatcaaataa tcaaaggtaa 2085421 tatcagcgat ttcaaacagc tcatcctcac tcggtatgta gccccgtctt gcaagctctc 2085481 tgtaaaaaaa ttcagcgatt tcttccgtat caatcacaag atctatttct ttcatctccg 2085541 taccgcctcc ttttttatgt tttatgaaaa aacaggctga attatacccg gtgttctaaa 2085601 caattctttc agtcatatat tgaataaaaa acgagccatg ggaggctgac gctatgattg 2085661 ctaaaatgat ggaagcactg gacggagaaa gatttgatat cataatggaa aaaacgctca 2085721 aaggaatgac gcgtgtgatg atttggggct gtctgccata ttttttatat gtcttgatcc 2085781 gtatgttcac aaattaactg aaatgctctt ttaaactttc caaaacaaac atcatcatgt 2085841 ctttatattc ttcatcctga aacatttcgt acagaatttt gtagtcatta taaatatcca 2085901 gaagctcatc aacaattgac acagcaagga tgtgaagggt atcttgatct tcatcaccgc 2085961 cttcaaactg aagaagagca gacgatgcga tatcttcgcc gatctcatgg ccagtttctc 2086021 cgacataatg gacaaacaac agctgatgca caaactggtc catttcatat tttctaagca 2086081 ccagcgtgag atcctcttcc tccgtttcaa gccactctcc atcctttaaa cgggtcagct 2086141 cataaatgat atcttcccag ccatcttcta aatatctcca aatttctgtt ctatggccga 2086201 taatgcgaaa gagttctttt ccataatctt taacataaac aacgtcccca ataaggaatt 2086261 catactcaat atcaagcttc tccatgtcga caatgacacc ctcataatct ttataaagct 2086321 gaatagatga ttcaaagtat aaaacttcgt tatgattgac ttcataaaga tagtgtttat 2086381 caatttggtg tacttttgtg atggtgccga ctgttccata cataatgacg actacgatat 2086441 cccctacttg gaatttcggt ttattttgct tcatggtgtc tccccctcgc cgcaacattt 2086501 ctcatacgct atcgtatgcc gggtgaagcc aattcgcatg ggcatgaaaa ccaaaggaaa 2086561 tatccaatta tggtatgggt atggacataa aaaaatccgc agtgatctgc ggatgaaaca 2086621 gctattatct gccgtgcact tcagactcgt attgatccca agcttcatca aacgtcgcca 2086681 tcgtgtgaag gtaatcagca ttcagctcca aatatgaact gatttcatga taatcggttg 2086741 atgtttttgg aaagctgtga tcctcatacg cctgattggc aaattcactg atgctgtcct 2086801 tcggcttagg gtgtctgtat ttcaataaat agtgataaaa ggatttcatg ggtttcccct 2086861 cctgatgtct gtcttttgtt gttctattat acagttcaag tgtaaaatta caacaaaaga 2086921 atactgaaac atgactcagg agaagtcaaa atagttgcgt ttcaaaattc tttctgtctc 2086981 catgagctgc tgatatgtca ggctttcagg cagttttttt gtttgaatta aaagcagctg 2087041 atcctcaatc tctttaaccg tgttttcctc ttgataggtc ataccgcagg aagaacatac 2087101 catggcaggg gtgtctgtca gttctatagc cctcgttcca tcagggagct cccagtacac 2087161 cgtgttcctg ccgggcaccg cttcgagctc gccgcaccat tcgcatgttt tcatgaagaa 2087221 tcccctccgc attcagtctc tttctgtttt ttctgctgcg ccaaaaattt cttttctttg 2087281 agctgatctc ttttctcacg ccgatctttt aatgtttcat gctccggatt tgcgatgtat 2087341 gcctctctcc ttttgattct gtctacattt tcaggtgtaa acgaaacttc tttgtcagca 2087401 aaaatggcac tcagcccgat cggctccttt ttgtcagcgg tttcagggaa aacggactca 2087461 aaataggcgt ctgcctgatt ggggatataa ttctctggtt ccggatatga cgtaatcaca 2087521 ccttcaaaat ttcttaagat cactttgtca ggactttgtg acaggacata gtttggctgc 2087581 agggcgattt tacctcctcc gcctggtgcg tcaacgacaa aggtaggaac cgcatagcct 2087641 gaggtatgac ctctcagccc ttcaatgatc tccaaacctt tggaaacagg agctctgaaa 2087701 tgccctattc cttctgacag atcacattgg taaatataat aaggacggac tctgattttt 2087761 accaagtcat gcatgagctt tttcataatt ggaaccgaat cattaatacc tgctaatacg 2087821 acagcctgat ttccgaccgg cactcccgcg ttcaccagct tttcacatgc ctcaacggat 2087881 tcttctgtca tttcgatgct tgtgttaaaa tgggtgttca gccagaccgg atgatatttt 2087941 ttcaatatct cgcacagatg atcggtaatg cgctgcggaa agacgacggg agctcttgtt 2088001 ccgattctga tgacttccag atgcggaatg ctgcgcagct cttttaaaat atattctaaa 2088061 atttggtcgt tgatgagcag cccatcaccg cctgaaatta aacaatcgcg gatttcgggt 2088121 gtttcccgga tataagcaat tgcagcatca agctgttttt tggggacgcc cattccgatt 2088181 tgtccggaaa agcgccttct tgtgcagtag cggcagtaca tggaacattg attcgtgaca 2088241 agaaacagca cacggtcggg atagcggtgt gtcagaccgg gtaccggtga atcttcatcc 2088301 tcatgaagcg ggtcttccag atcgtatttt gttttgtgca tttcttcaga aagcggcaca 2088361 gactgcatgc gtaccgggca tctcggattg tcggggtcca ttaaagaagc atagtaaggt 2088421 gtaatattta aggggatcgt tttggtagaa attctgacgc cttcctcttc atcctcggtc 2088481 agattaatga ctttctttaa atcatctaac gttcttacag tgtgtgtcag ctgccaaagc 2088541 caatcgttcc atttctcttc cggaacgtcc ttccataact cgatctcctt ccaatgccgt 2088601 ttcggtttat accatttgtt tttcaaacga actcctcctc gcgcatattt tgacttacag 2088661 ttgcttgcac caaatattca tgttttcaag gccttcggct ataaagcaat tattgatcag 2088721 ccttccgcca tactgataac ctgaatggta caacacagca ttcatcccaa aagacgaagc 2088781 acgggcgaga gaaaacacat gaacgatatc ctctccagcc atttcttttt ctaacgcctc 2088841 gattaaaaag cttgttaacg aatggccgcg atattccggc agcacagcgc aatcggttat 2088901 ttctgcatgc ccaagctctg gattgatttc tgcgcttgct gcgctgatca ggcggtcatg 2088961 atcaagcatg atataataca ccgtatttgc attcatcgtc ttttcaatat aagcggggtc 2089021 aaataccggg gttgggtacg tgcggaatac ttttttatac agcatcgata gctggtacat 2089081 gtcgtttgtt tctgcttttc tcatcgtaaa aacgggtgta ctgtcgttgc gaagacgggg 2089141 cgctgtgcga tatatggctt cgatgatctc ctgttcctct gtataagaat ctgtttgtct 2089201 ccggctttct gaaaggtaac gtaccatgac acaagccgaa tggccgagat aatagccctt 2089261 tagatagccc tccggcgcaa ataattgttt ggcaaggatc ggctcatcat gctgcttcgc 2089321 atagacaatg attttttctg cattctcttc ttttgccgct gccacgatat ccggcagggc 2089381 cttctcaatg gctccgtcat aacgaaccac tctgattcgt ttattaaagc cgtcatggtc 2089441 caaaactgct gtgacaccgc tactctttat tgacttgagc atccgcatcc tccccatctg 2089501 tatgaaggcc gcaccaatcc atgacaaaaa gtgcaataat tttagcagat tctatcatgg 2089561 cttcaacctc aatgtattca ttggcctgat gagccgtttt tgtttccccc ggcccgaaaa 2089621 cgatcactgg tgtatctcct gcatggtaca aaagccctcc atccgttccc cacggggaag 2089681 cctcaataat cggctctgtc tgtttcattt tttgataggc tgattgcagc acagaaatta 2089741 aagggtgatc atcaggtaaa tcattcggca gccattgagc gccaaaccat tcgacttgta 2089801 cgggatggcg tttaaaccat tcgtcatggt attctaaatc cttcagccag ttttccaatt 2089861 caagttttac agcttctggt ttctcatggg gagcaattcc gcatctccct tctatgacga 2089921 cacggtctgc aactgaagat ggccaggcac cgcctgagat ggtgccgata ttcaccggta 2089981 ccggtattgg gatattgtca tacagcggat ctgaaattct cgcattgcgg actttctcca 2090041 gctcttgtat cgctgtgata acgtgcatgc ttttttcaat cgcgcttacc ccttcatagc 2090101 gtgtgccccc atgtgcggat aatcccttca cagtgatccg aaaccacatc gaaccctgct 2090161 gcttaataaa tagtttcata ttcgtcggtt caggaatcag cgccccgtca gcacgatagc 2090221 ctctcatgat ggcggaaagt gtaccggcgc cgccgcactc ttcatctaca acactctgaa 2090281 acaatacatc tcccttcagt ttgacatcgc aggcgtgcag ggcttctaaa gcaaaaagaa 2090341 gggctgtatt gcctcccttc atatccgttg agccgcggcc gtatatttta ccgttttctt 2090401 cgacagcttg atacggttca tacttccaat cctttacgct tccttcaggc acaacatcga 2090461 tatggccgtt caaaatcagg gacctgcctc cgccggctcc cgttttttta gccacgatat 2090521 tcgggctctc atgaaaatcg gatcggttag atttaaagta gggatgctgt tttaattgct 2090581 ttatgcttgg ctcccataca tcaatgtcca tatgaaattg ccgcagcttt tcaagcacaa 2090641 cagcttgggc gttaaactct gaccccaatg tgcttttttc cccaatcagc cttttgagaa 2090701 gacgaatggc tttggccgaa tgctgatcaa gccactcgat tacttttctt tcaatgtctt 2090761 gcatcctcat tccccctctt aagaaaaagg catatctatt ttgatttcag cttctgtcag 2090821 cctcgtcacc tcatcgattg tcgagccatt catcagctct tttaaaatga agtgatggct 2090881 atcgacctca agaaccgctt tttcggtaat aatcaaatct acacagcctg cagcagttaa 2090941 tggcagcgta catctttctg ttaatttagg ccttcccttt tgatctgtat gactcatgac 2091001 gacaaccact tttttcgctt tttgggcaag ctccatcgcc ccgcccatac caggcacctt 2091061 ttttcccgga acaagccaat ttgccaaatc tcctgattgg ctcacctgca gggcgcctaa 2091121 aatcgtaatg tcaattttgc cttttctgat catcgcaaaa gacatggttg tatcaaaata 2091181 agaagcccct tttacagcgc ggacaggata tcccgcggcg ttgcataaat gcgcatcctc 2091241 ttctcccttt tcgggacttt ctccaatgcc aaggacaccg ttttccgctt gaaacatgac 2091301 ctgcatgtca ggcttcaaaa agttcggtac caaggaaggg ataccgatac cgagattcac 2091361 aatcatgccc tgcttaattt cagtagcagc gcgttttgca atctgttctc tttctgctac 2091421 tcccaagccc atttccactt cactccctcg cttcgtacaa ccccctcaac aaaaaccccc 2091481 ggtgtgacaa tcatttcttc agaaatctcc cccatcggaa cgatacgctc agcttcggca 2091541 aaggttctcc tggcggccat tgccataagc gggttcatat tgcgcgcggt tttgtcatac 2091601 gttagattgc cgaattcatc tgcaatgtaa gcattgatga aagcaaaatc agcagtcagc 2091661 gcctcttcaa tcaagtatcg ttttcccgcc actgttacga tgtccttttt ttcgcaaacc 2091721 atttgattat caatgcccac gtcggttaaa ataccgccaa gccccgctcc gccggcgcga 2091781 atccgttccg caagcgttcc ctgaggtgaa aattgaacct ctaacgtccc ctctgtcatc 2091841 tgttttccgg ctactggatt ggaaccgata tgcgaggcga tcagggtttt gacccgttga 2091901 ttaacaataa gcgggccgat tccgatatcc gggaaaccgg cgtcattgca aatcacagtc 2091961 aaatccgtta caccgctgtc caatatcgct tcaatcaatg aaggaggcga cccgactccc 2092021 ccaaaaccgc caaacatcag aaccgatcca tcccgaacat ctgcaattgc tgtgtcaatg 2092081 ctgattgctt tttgaaatgg cgccatttaa tgtcaatcct tttttaagtt tttttcgacc 2092141 gctgcaactg tttctgaaaa aatagagata agctcttcca tttcaccgtc tgaaatagta 2092201 aaaggaggag caataatgac agcatctcct tctccactgt ctattccagc tttggaagga 2092261 taaacaatca gcccgcgttt tttcgcctcg ctgacaataa gctgggttat cgcctgctct 2092321 ggcggaaaca ctttcttcgt tttttggtct gccacaaatt caatgcctaa tagcagtcct 2092381 tttccgcgca cctcacctat aatgccgctt tgagatgccg cctcatcaag cttcttcttc 2092441 agcacagcgc cctttttttc tgattgtttg atcaagccgt gctttaacac atatcgcaaa 2092501 acttcaagag cagctttggc tgaataggga tgtgcactat atgtgtgacc gctcataatc 2092561 acacctgacc cttgttttat ggtttcaata atagaatcag atacgacggc agcagcaata 2092621 ggtgcatacc ccgcaccgag tcccttcccc agtacagcaa tatcaggtac ggtatcccaa 2092681 tgctctgtcg cgagcatcct tcctgttctc ccaagccccg tcatcacttc atctgcaata 2092741 aaaagcacat cgtgtgtgcg gcatacctca cttaatctct cataatatcc cggaggcgga 2092801 gtaatcgctg ctcctgcagc accaataata ggctcagcca caaagccggc gatgaattgg 2092861 cttccgattc ttttaatcat ggtgtccagt tcatcagctg cagtctgaac aaagtcttct 2092921 tccgtctcgt gattcagccg ataaatatgt ggagctgaga tagctggata ccgctcaatg 2092981 agatgggtga accggtatct cctttcataa aaaccagaca atgaaagcgc tcccaaagtt 2093041 attccgtggt aactgctcca tcgagacaaa aagatggatt tttgtgtttg ctttttttcc 2093101 tgccaatact gaatggcgat tttcatagct gtttctatcg cttctgatcc gctgttgaca 2093161 aaaaaagacc aattcacatc tccgggcagc tcctgtgcca agagagcggc taattgctcg 2093221 gcgggctcac tcgtaaactg tgagcggtaa gcaaaagaca cctgatcaag ctgttctttc 2093281 agcttctcag tcacatcacg aactccgtgg ccgatattac atgtcaccgc acctgacgag 2093341 ccgtcgagat atttttttcc ggtctgatca taaacatatg aacccttcgc ataactgaca 2093401 accggatagg ccgagctaag ctctggctta atcaaataac tgctcatgct cccacctcaa 2093461 aacccctttt accatattgt atgagtgtcc aaatggcggc atgacgttcc ccgcaaaaac 2093521 tttttcacat aaaaagagcc ttcctaataa ggaaggctct tttgaaattt cagcatctag 2093581 caaataaaag cggctccaac aataattaat aaaatgaaca agacaacaat taacacaaat 2093641 gtatttgtcc cgcagccaaa tccgtaaccg tacccagagt atccatacat gctgttttca 2093701 tcctttctta tcacgatata cgacatttta tgcgggccaa gtcccaaatg gtttgtgcaa 2093761 acgcctattt catgtaagga aataatgaaa tacagtatgc acccgctcat attttttaaa 2093821 cgtcagcttt tcgtaaaact gagttgcacc gtcagtgctt gcagccacta agtaggctgc 2093881 ttccattcct agtgatttgg cgatggacag catttctttc actaagatac tgccgtagcc 2093941 cttcctttga aactgatcta aaattgccac ttcttcgatt ttagccgttt tctcttgatg 2094001 atcgataaac agctcgccgc acccaatggg aactttctgt gcctggtcgc tgtaacaaac 2094061 aacaagaatg attatatctg cttcatagaa aggatatttt ctttttaatt tttgttcagc 2094121 gattgcttct ccaatataaa tggaatcgta aattttcata atagaagatc cgtcgctaag 2094181 actttttgcc gtcccccatg cggttaaagg atgtcccatc tgccccttcc agtcactaag 2094241 cttcatgtca tatagtagct catcctcgac gacaaaaccg ctttttacaa gtgactgctt 2094301 caaaccgagc ggaaaaacat gctgcggcga cgcttttaaa tggagataat tcgcatcaag 2094361 cagctttggt acggagggta aaaagttaag taaccgctcc aatggaaacg tatcatggag 2094421 ctgaacaaag ttatgagaaa aaatttgcgg aagctgcgga tctctgtata cgctgtaatg 2094481 atcaaacgat gccgattcag acgttaacaa tatatattga tgttccgttt ttgaataatg 2094541 tcctgtcatg aacgtctcct ttttatgacc tataccttta ctctgttgca atattcaatt 2094601 tctttataat ctcatcgtac accggataaa acggctttcc aattggaaat tgctgaatat 2094661 ttcggaaaga agcggagatt ggcttctgat gtaaaaaaaa cttccttgtt acttgttcac 2094721 taatcgggtg aaagacgccg tttagaaaca aaaacggctc gcgttcgatg aaaaacagac 2094781 gtcggccagg cggatttttg atcaattcag atcgtttcca cgtaatcggc ggcccttccg 2094841 gaagcgtctc catctcttct tttccaattg tcactatgtc ttttctttga aattgataaa 2094901 attgaaacgc atactggtcc acaattcgcc ttttttttcc ggcttcgata taaaatattg 2094961 caggatggtc agcttccttt actaaaatat aattcggaat gtttaaaatt ttgccaatcc 2095021 tatattggaa taaatatggg tctggaacag cgacagtccg atttagatac aaaaaacccc 2095081 acttttctcc aacaggatgc cttacaccct gatcaaaaaa atacacattt tgatctgaac 2095141 cttttacaaa agagccgtca atcaaatcgg cgggcagaaa ccgatatgca ttttgaaatg 2095201 aatctggggt tttataggtt gtgtctaata cttcatttat cggcagaaat ggggtaaagt 2095261 tgttgagtct cgcccaaaaa attgcgtcgc catgattcca atgcttcata tcatcatccc 2095321 agtagcctcc aaatttatgg tgaatgagat taagtaacga acggcgatgc ataactgagc 2095381 aatgatcaac ttgaaaagcg gcctgatcaa gcactgcatt ggcatttctg tagaaatgtg 2095441 agatttcctc tcccctttcg tttacatgta caactttttg ttttgaatag accgcctgcg 2095501 cttcaggctt atgtgaaaac tcttgcacca tacggctcag ccgctcagga tgataaacag 2095561 tgtcgtcagt aagataggaa atgtaatcgc cgtctgcaaa tgggagcgca ctgttaatta 2095621 atgtggcata acgggctgtt tttaatcgat ctgcaggatg cacgaaactg ttatgatatt 2095681 gaatgcgccg gtcatggaga tacttgtgaa tcaccgcagt tgtttctgca ttcgaatgat 2095741 catccatgat aaaaagctcc caaagatcat gcgtttgctg tatcacgctt tcgatcgctt 2095801 tttgcaaata atcgggtttg ttgtaacttg ttaaaataat agacactttc tctcccatct 2095861 ataccgcctc ccgccgtcaa acataaaaac ggctccgcag caagcagagc ctctgtcatc 2095921 atttaaaaag caccccagct tacaacactt gagagtgaaa catgagatct cgtgttattt 2095981 aacgggtttt ggaaaataac caaatcagtc agaacttctt ttacgatgac attttgaagt 2096041 gtatctccgt tgatcaaatt gacttttgaa accggtacgc ccagctcttt tgcaaaaaca 2096101 agctggcgtc tgaggtcaga tggatttcct tcagaagacg attgacgtat cagcagaatc 2096161 agcaaaagca aaataaaatg cagatcatct tggttttctt ctcgatccac ttgtttctct 2096221 aaatccaaat catccctctc ccttatcctt atctctgttt cacaatatgt gcgacttcga 2096281 tttatggtat aggctatgtc cactccatta aaaaatcagc attttcctta aatagatgaa 2096341 aaatagatca ggtacggcgt tcgactcata ccaaataaca gccggaagaa tatgaataac 2096401 gtgagttcac tatcgaatag gaggtgtgtg taatgagctc tgaaaatgca cagttaaaaa 2096461 aggatttaat taaagccgtt ttaagccctt tatttccaac tgcaacagaa ggaggagaaa 2096521 atatggatag taatcttaaa gccttgcttg atgctgccat cgatcaaaaa gtagatgaaa 2096581 gtgaaacggt tacggcagaa tctattttag acccttctct tccggcaaga tggatttttg 2096641 ccagaattac gccaggcact acaatcagca ttgtgactga ttcaggtgac atgatcggac 2096701 cggttgtttt cgttgctttc gatcaggttc acgggatcgt atttgtaaca caggaaagct 2096761 ccgtcactcc ggcaggccaa gctacaacat taattgatgt agacaaagta gaaagcgtta 2096821 cgttcttttc ataacatccg atgaaagtct tgtatatcca gtcgggatac ggaggaatat 2096881 acagttattt tgatcgctgg gctgaagaat gttttcagaa cactcataca gagtatatga 2096941 ttgcagataa acctgaagca gaatctttga tgaagatcga agcgtttcag ccggatttca 2097001 cacttatgat ggttggagac cgcgttcctc acgactggct gacctggtta aagggtaagg 2097061 atatccccgt gtatgtttgg ctgaccgaag acccatttta tatggatatc agccttcagg 2097121 taattaagct tgctgacgcc atattaacga tagaacaaaa tgcagctctc tactatcaag 2097181 agctcggcta ccagaacgtc tattatgttc cgataccagt taaccatcgg ctgtttaaaa 2097241 aaatgggcac cgaacattcc tatcattcaa atctgttaat catcggctat ccttacccta 2097301 atcgggttca gcttatgaaa gaagcggtcc atctgccatt cacggttcgg gtaatcggca 2097361 aggaatgggg aaaatatctg cctaaaaaag tgctcaaaca gccgcatatt gatgtcgtca 2097421 gcacatgggt tccacccgaa caggccgttc attattataa tggggcagac atcgtaatta 2097481 atgcgcatcg tccctatcat tttgctttca accaaaatac tatgcgcatc aaaaatgcca 2097541 gttttaataa ccgaacgttt gatatcgctg catgcgaagc atttcaatta acagatttac 2097601 ccgcggcgca tcctttttca tccattattt cttatcacgg catgaacgac tttaaggaaa 2097661 aagccgcttt ctatatcaac caccctgaag aacggcaaaa agctgcagca gccaattata 2097721 aagagaccgt acccgcattt acgtttgatg agcttcctgc aaaactaaaa gcgattcatc 2097781 tggcgctttc ttgaaaaatc gttcattgct atgaacgatt tttttattca tagaaaaaag 2097841 cagctgcaca agctgctttc tattctagcc gtcagaacgg tctttcagct tcctcggatt 2097901 tacctgttta tgaagatcag gcatttcgcc gagatgctgt gcaatttgtt cccacgatac 2097961 aattttgaaa ttttgattga cggcttgtcc gttatcaata ttttcgccgt cctgcgccac 2098021 aaaaatcccg tacggatatt ttgggccaag tccgaaaccg agaacatcaa taccatccgt 2098081 gtcactagta ccgtctatct tctcgccatc tgtaatctca aagttggcta catagcgatt 2098141 tttcccctgc cgttcataca ttgcatagct gttatttcct tgacttgaag ccatgagata 2098201 tcctttgcca tttggtgcat aatagattgt cagtccttca atatcagctg tcaaatgatc 2098261 tcctgtcgca cggtcaacaa cctgcccctt tgaccctccg ccgggctcag cgttaaattt 2098321 ccagatggcc tcatcttcct ctgctatgta taggtttccg tactcatcat ccgcaacaag 2098381 gccttcggtc tgagaattca acttaaattc acgcaccttt ttccctgtta cataaccctt 2098441 tccaccatca acaatttcat actgctcaaa ttccccttgt ttgcctgtca ctaatgcgta 2098501 aaatgctcct gttttctggc tgtgatacaa gctgaatcca taaacctcag aaatattggt 2098561 ggaaatagga tggttcggat ctgtaatgct tttcaatttt cctttatccc cgtctattgc 2098621 atatacttca attgtatttt ttccttcgga ccggttggat gcggcagcaa tatcaatttt 2098681 ttcgccgttc aatggaaaat catagcgcag atcgacatta ttgagcttgc caaactcata 2098741 agaatgaagc tgttttccgt ctaaatcata cacaacgagc cctgacttct tatttgttgt 2098801 aatcaacttg cttttttccg ggtgtttttc atgaacccaa atggccgggt catctgctgc 2098861 atcatcgcca gatgcgaccg gatctgtctc cgtgtgtgca gtcactttga aatgatgttc 2098921 ctcattcaca taatgagccg acaccgaggt tgctgtcagg ctaagcaata aacccgcggc 2098981 agtgcttagc agcattgttt ttggaacctt catttggtac cctcctcttt tatcactaac 2099041 actactattg taaaatatat acaggtgatt accgtgagga aaatgaacct ttttttatag 2099101 ggtttctgac tcataaacaa cttattcccc aaagaggtgg tgagatgact ttgccagatt 2099161 tacttttgcg gagcgaaata aaaatatgtt gaatatttag tacattattt atttagtttt 2099221 gtttttccct agttacgtcc gtttttccat tttctattaa aaaagaacac tttgtgacat 2099281 gatcattccc ctaaattttg ttttattggt tgctttcatt aattcgatta caaagttgaa 2099341 catatgatgc atggtagaga aacgagagtt ggaggataag ccatgcctaa acagcaaaca 2099401 gcagaactaa aaccattttt ccataacaaa acagttttag tcactggcgg aacgggttca 2099461 atcgggagtc aaattgtcaa acgccttttg atgcttacac ctaaacaggt gattgtattc 2099521 agcaaagacg acagtaaaca gtatgtcatg agccaaaagt atgcggagga taagcggcta 2099581 ttatttgtac ttggagatgt acgcgatcac agaagggtga atcaggtgat gaaaggcgtc 2099641 gatatcgtct ttcacgcggc tgcgctgaaa caggttccga catgtgagga ccatccattt 2099701 gaagcgatcc agaccaatct catcggcgga caaaatgtgg tggaagctgc cctttcacac 2099761 cgagtgcagc atgtcattaa tatcagtaca gataaagctg tatctcctgt gaacacaatg 2099821 ggtgccacca agctgttatc tgaaaagctg tttcatcaag caaaccgcca cgtccaaaac 2099881 aaaggaacct tgttttgttc ggtccgcttt ggaaatgttc tcggttccag aggttcggtc 2099941 atccccatat tatttgaaca gatgatggag ggtgaacctc tgaccatcac agacaaaaac 2100001 atgaccagat ttttcatgtc aatagacgat gcagctacat tgacattaca atcggctgct 2100061 attacaaaag gcggagaaac ctttattttc aaaatggaat cactgaaact tgaagaactg 2100121 attcatgggt ttgaagaata tgcatcgcag cacgggctcc cgcggccggc tgcagtagaa 2100181 gtgggcaagc gtccaggtga aaagcttcac gaagaattaa catctccaca tgaaattgaa 2100241 tcactgtatg aatggggcaa cctttatgcg atccttccag agccggaaaa acatcctgac 2100301 tttcgcaaag tcaatctgcc tgggtatcaa tcagatcaag ccccgctcat tacgaaagaa 2100361 agaattgctc agattattga agaattgcat caagagaaaa aggcataaaa acaagcctgt 2100421 ctatccatta ggcaggcctg tttttaacag tttatttatt aaagagatgc agatagcttt 2100481 cgtatccttc ttcttttagc ttatgcttcg gaacaaaccg cagcgctgct gaatttatgc 2100541 agtaacgaag tccgtttggc cccggtccgt cattaaatac gtggccaaga tgagaatcag 2100601 cagttcggct tcttacttct gtgcgaatca tgccgtggct cgtgtccagt ttttcttcca 2100661 cttcttcttc aatcggcttt gtaaagcttg gccagccgca ttgggaatca aatttatctt 2100721 tggatgtaaa caatggcttg cctgacacaa tgtctacata caacccttct tccttatgat 2100781 cccaatattc attttgaaat ggcggctccg tgccgttatt ttgcgttact tcatattgca 2100841 tgcgatttaa tgactttatt ttttcttctt tattgtacgc catttattta gccccccaat 2100901 gctcgctgat aaatcccgct cgtccggaac ctgtccggta gcgctgataa tgtgctggat 2100961 tctttttata aaaatgctga tggtagcctt ccgcttcata gaaaggttca gcttttaaaa 2101021 tgtccgttac aatcggatct ttaaagatgc cgctttccgc cagacgttgc ttggaagctt 2101081 ccgcaagctc cttttgttta tcattatgat aaaaaatggc tgcgcgatag gaactgccgc 2101141 gatcagcaaa ttgccctccg gcatctgtcg gatcgatttg ctgccaaaat aattcaagca 2101201 gtttttcata agggaataca tcaggatgaa acgtgatttg aacggcttca cgatgtcccg 2101261 tcgtttcact gcacacctct tcgtacgtag ggttttcagt atggccgcct gtatacccgg 2101321 acaccacttt ttcaattccc ggctgttcgt caaaaggttt aaccatacac caaaaacagc 2101381 ctcctgcaaa tgtggcgatt tctttttttt cagacatact ggtgcctcct ttgttaatac 2101441 gtggtattat tatattatag catgtaaaaa tagaatgaaa atgattctgc ttttcaataa 2101501 aatctatagg ttttaagcaa tatgcttatg taatggaggt tcacaaattt gaaagtaaga 2101561 acacagatga tgtacgatat ggaaacttta ctccgtaaag tctttaaaca aatacgcaat 2101621 gaaatcaatg aaattttaga taaagagctg tcgcggaatg aattcaccat tcttcgaatc 2101681 cttagtgaac aagggcctaa aaaagtcact gaatttgcgc ctattttaga ggtatcggca 2101741 agccacatta cggctgtgac cgatgcgctg gtagaaaagg aatggattac gagaatcaga 2101801 tcgaaggaag acagacgcat catccgcatt catatcactg aagcgggcga aaaagtcctt 2101861 cagcacttta acgagaaaaa aacggaatat ttctttaaac gctttgactg ctacactgat 2101921 gctgaacttg ccacgttaat cgagctcttc agcaaacttg ataaaaaacg gtgaaaaaaa 2101981 gcacataccg atatataggt atgtgctttt cgcagtgctt cacttatttt tcagtaaaca 2102041 gcttcattgc tttccagcgg ccatatctat aatacaaaaa tgccgcgcag ctgctaaata 2102101 aaaaactcat tccgattcca agcccgattc ctttttgtcc aagccaagct gaaaatagag 2102161 ctgtgaaagg atacctcaac acccaaaacg agatcaaatt taataccaga acctgcagca 2102221 tcgctcccgc ggccctgacg attccgttca gcacaaaatt aaccccaata aaagggtaga 2102281 aaaacgcgat ccacttcaaa tattgttcac caaatgcgac cgcatcaggc tcactgataa 2102341 ataaccttat gaggtattta ccaaataccc aaatcataac cgcaatcacc agcatgcagg 2102401 aaataacagc tatcacacct agccttgcaa ttgttcccac tcttttttcg tttccgattc 2102461 caatattttg ccctgccata ctattgacgg ccgtaccggc agccattgct ggaagcgtga 2102521 tgatgctatc aagccgctgc accgcgccaa agcctgatac cacgtgatcc ccgtatgagt 2102581 taacaacact cataatcgcc atcataccgc ctgtaatcac catcatctgc agacctgccg 2102641 gaatcccgag tttcaaaatc agcgcggact cttcccactt gggcattctc ggaatcgaga 2102701 atggcacaag cttgtgtttg atgacataaa acaacccata caaaaacgca atgccctgtg 2102761 acaaaatcgt tgaataagcc gctcccgcta ttcccatgcg gaacacagaa ataaagagcg 2102821 gcgcaagcac tgtattcagt acaacagcaa acgcaataaa ccggagaggt gtcttgctgt 2102881 cgcccagcgc acgaagcaca gtactgataa agttataacc aaacaaaaat aaaatgccga 2102941 taaattgaat ctgtaaatac gtctcagcaa gcggtatcat tgactccggc gtttttagaa 2103001 gacgcagcaa aagctctgag agaaaaaaac cggccgcgcc gaatccgatg cttaggcctg 2103061 ttaataaaac aacaaaagcg ttaatatacg acgccattcc ttttatatca tcttttcctt 2103121 tttgctgaga taaaatggtt aacgtcgcat tgttaaggcc caaaataaaa gacagcacgg 2103181 tcaaaacaat cgtgcttgat accgcggctg ccccaagggc ctttgccccc agtaaattgc 2103241 cgatccacaa gctgtctata aattgaaagg aaacctgcaa tgcgtttccg agcataatag 2103301 gcattgaaaa cagtacaagc tgtttcagca cgttcccctg tgtaaaatcg tatgctttca 2103361 tcttttctcc ttgtgttctc aaattttctt cggaccacac gaaaaaagag acgttgtttc 2103421 atgtctcttt tttcatgact tatcggtttt ttttcggtct cgcataccga atgtaaacac 2103481 catcacactt aggaacaagg cacaatagga aacattcaaa tacatttgat ccatatcttc 2103541 agcagccaga tgatgataag caagccagcc gaagtacagg gaaaatgtaa aggataataa 2103601 actgaaatac tggtaaatcc gtttcatttt cagtcacctc tattgtttag gatggtaata 2103661 ggaaaactca atttcatctt tttctaaatt tatcttatcc gctttgacat acattccatt 2103721 cgttaaaggc atttctgaca aacgcacttc aatgctttta tctccggggt gaacatggac 2103781 aaatgacggc aattcataaa agctgtccat ataatttaac acaaagctaa ttggtatact 2103841 caatttccct aacgaaaatt tcgtgacatt cagctctaca tcaccgtttt ttttcacggt 2103901 cggctcaaaa gcgataaacg catcaataga cgtggaaaat gccttgattt tccctgcgac 2103961 atgaacatca tcatcaatct ctactttata atcaagcttg tttgatgctt tgtcgtttaa 2104021 atatgagtta acaaacgcag ctaatgattc ttttgtgctt gtcacttgaa atccatactc 2104081 gctctcagat gcatctttca cctgagcctg ttcccccgga agcaaaacaa gtgccacaaa 2104141 cccggcggcg aggataaaat tgattgcaag caatataaaa aacagtcgct tccacttatt 2104201 catgctgtca ccctactctt tcggtaatcc ttctttttta atggcttgat agacgcgctt 2104261 tgcgataaga gaataacccg taccattagg atgaaaatca tcttcctcag aaattcggct 2104321 gctgtcactt ttttgattaa acaaatcttc gatatggacg atttttgcat gtttatcttt 2104381 tttcagctct ttttcagcaa tatggttcca atccgtgacg acaccattta tttcatttag 2104441 ttctgataat gtaaacgtaa acggattgta catgctgaca taaatcagct cagcgtgatc 2104501 attcagctcg cgaatttcag aaatgatttt ttcaaagcgc ttttcgtacg gtttttccgc 2104561 ttcctgaaac ggttcaacgg ttaattgcag aaagttttgg cgaaggattt tcatcaaatc 2104621 attaccgcca attgtaaaaa agacataatc tgcgtccttt atgccttttt gaaccttttt 2104681 atcttttagt ttttctaata aatcatccga acggttccct tttacagcat aatttttcac 2104741 gtcgaccgtt ttgacttgtt tatctgaccg gatagaatcc gccaccttgc cgacatatcc 2104801 ctttccgtcg ggatctccga ctccttctgt cagcgaatct ccgacagccg ctatgacaat 2104861 gtgttctttt gttttcgttt catgggcttt ttgttttccc tcagatgatg tacgtatgct 2104921 cgtacacgca gtaagaagca aaatcaaact ggccatgatt gaaaaaatgc gcagcttcaa 2104981 tcttgttgct ccttcccatt ctactagtgg aaagtgtatc atgttttaga agatttgcaa 2105041 atgcctagtc tcttagctta cttgagtgta ctggctgact tcacatcgga aatgatatca 2105101 tcgtacggtg tattctccac tccattgtaa tctttcagca ccttaccgtc cggacctacc 2105161 aaataaaaag aagattgatg aatcacttgg tcctctccct ccggcttctt tacgatcgct 2105221 ttaaagctct taagtgcgaa ctcctcaatc tcactctggc tgtatcccgt gagaaaatcc 2105281 cagttatcaa aagataatgg ataatttgcg gcaaatttct tcagctgttt cggcttatcg 2105341 ttttctggat caacactaaa tgatatgatg cggacatcta tattttcggc tttcagtttt 2105401 ttttgcagat cggtcatatg agcggtcatt ggcggacata tagtttcaca attggtaaaa 2105461 ataaaatccg ccagccatac ttctcctttt aaactctcta aagaaacgtt cttgccgtct 2105521 tggttttgaa atgtaaaagg ctccacctcg taattgagcg gatctttaat ctgctgtcct 2105581 ccgcatgcac acaaaaacag aaaaatcagc ccagccgtta accccttgat aaccttcatg 2105641 acatccatcc tttccagcca gcataaaaac gctttctaaa accgtcctta ctgtcccatg 2105701 tttgtattcg atactgagca aaaaaaatcc tgcatgcctc cccattaacg attacaaagg 2105761 agggcatgca ggtaaaaaac ggcatgttac gcgttgtgct ttaacacctc ttgatgaaat 2105821 acagcctgat aatctgccca cttcatccgc cgcttcatat aatgtcggaa agaatacact 2105881 tttgccctgc tgtttgatga aaacacttct tttaagtaga attgcaaatg gtgatgtaac 2105941 ataaagaaat agtgctcatc ttcctttaat acaggtattt ctgtcacttt cacctgaatc 2106001 ccgtcaccgc gtttgaactc taggcttttg agtaacaagc tatcaatcct cttttttgtt 2106061 tttcttctat tatatatgat gccagccggg ctgtctgtca ttttgcgcgg ttgtgtaaaa 2106121 aaattagatt agcaaatgga acaagtcctc atccttgttc acctctacat aatgaaacgg 2106181 ttttttgttc atccgttcaa tcagcggccc ataatcggct ttgttctgca gctcgatgcc 2106241 gacaagagca ggtccattgc ttttattatt tttcttcgta tattcaaacc ttgtaatgtc 2106301 atcattcggc ccgaggactt cgtcaagaaa ttcgcggagc gcccccgctc tttgtggaaa 2106361 attgacgata aaataatgct gaaggccttc aaaaatcaag gaacgctcct tcatttcctg 2106421 cattcttccg atatcgttat tgcccccgct taccacacac accacgtttt tccctttaat 2106481 ttgatccttg tacaaatcaa gcgctgcgac agaaagagct ccagccggtt cagcaacaac 2106541 cgcacattcg ttatataatt caagaatgga tgtacatact tttccttcag gcacaaggag 2106601 aatgtcatca acgacagttt ccagcgtccg gaaggtttcc tcgccaattt ttttaacagc 2106661 cgccccatct acaaacttat caattttatc aagtgtgacg acatgcccag ctttgtttga 2106721 ttcaaagtag gatgccgctc ccgccggctc aacagcaatt acctttgtat caggagacac 2106781 gtttttcaaa tatgtaccta ccccagagag aaggccgccg cctccgacac ttgcaaaaag 2106841 aaaatgcggt tctgtatcaa tgtcgtttaa aatctcgact gcgagcgttc cctgtccggc 2106901 catcacatcc ggatcatcga acggatggat aaacgtccga gattccgcct cacagcattc 2106961 agcagcgctt ttatacgcgt cgtcaaacgt atcgcctgtc aaaataatat cgataaatcc 2107021 ttttccgaat agttcaactt gagatacttt ttgtctcggt gtagtagacg gcataaaaat 2107081 tttcccgtga atgccaagat gtttacacga aaatgccaca ccttgagcgt ggtttccggc 2107141 acttgcacac acaactccgt tctctgtctg ctcgctggaa agctgtttca ttttatgata 2107201 agcccctctg agcttaaaag atctgacaac ttgcaagtct tcgcgtttta aatagatatt 2107261 gcattcatat ctctcagaaa gtctgtcatt cctctgcaaa ggtgtgtgaa tgacaacgtc 2107321 ctttacgttt tggtgagcct tcaaaatgtc tttcacttgg atgagagagt tttctttaag 2107381 caacggtttc atgtacagat tcctttcttg ttttaaatcc ctatttaata tgccattata 2107441 acatgaatat tcaaaaaata agacaattat ttttatttaa taattaaaaa aatacagact 2107501 atgtccacca catcttgtgg taacttctgt tcaaccatta tcctgcagag ccaagaaaaa 2107561 agatgatcgt aaaataaagg gtgttttcaa ccaaaaggca tgatataatg aaaccaatta 2107621 gaaccaaaag gagccaattg atgaatagtg caccaaaact caatacattt caacatctaa 2107681 tcggagaaca tcaaactttt ctggaagcga agcgaatcgc caagcagttc tcgttatcgg 2107741 agcttcctgt cttaataaca ggaaaaatcg gaacaggcaa aaatcacttc gcacatgcca 2107801 tacacttgga atcttcgaga agcaatgaac cgtttataag cgtcaattgc agcacccatt 2107861 cggaagaaac ccttattcat gagctttttg gccctaacgg aaacacaggt gtttttcaaa 2107921 aagcggtacg aggaaccctt tttcttgatg atgtatggcg catgcctgct tctgtacaag 2107981 ctcagctgtt aaaagcgctt gattcagaca cggagaaacc gcgaatgatc tgtgcttctg 2108041 cagaccgatc cgtggaacat acattcaggc aagacttatt ctacagactg aacattttaa 2108101 cgctcacact gcccgaatta tcggaacgaa aaagcgatat tccgcttttg acacagcatt 2108161 ttctctcaaa ttctggtcag caattgttaa tcgatccctc cgtttttccc gtgcttgaga 2108221 agcatgcatt tgaaggcaat gtcagggaat taaaaaacgc tgcagattat atggcggcag 2108281 tatcaagcgg gggaacgatt cagccatatg acctgccgcc gtatattaga ggcacgatag 2108341 acggaaaaac gtcgaagaaa aaagcgaaac tgcttacttt aatggaaaaa gctgagtttt 2108401 tgtttatttt ggaaacaata aaagtattga acgaaaaagg agaacctgcc agcagacgga 2108461 tcatttctga acacagcaaa aatacccaaa cctcgttaac tcctcagcag gtcagaagcc 2108521 gtctcgacta tttggagaaa aaagattatg tcaccaaaag ccgcggacgc gcaggcacaa 2108581 aaattacctt tgagggcttg agctttatag agacgttaaa aaatcaaatg atctagcgat 2108641 cgaaaggaga atgtacttgt ttacaatcaa agaagagatc gccaatgcga ttacacacgg 2108701 catcggtgtc ctcttatcca tcccagcatt agtgtttcta atcatatttg cggctaatta 2108761 cgggtctgca tgggacattg tcagctttac aatattcggt gtctctatgc tgctgttata 2108821 tttgagctcc accctgcttc acagcatcac acataaaaaa acgaaggaca ttttggagat 2108881 tattgatcat agcgcaattt acgtactcat cgccggaacc tacacgcctt ttttgcttgg 2108941 gccgctgaaa ggcacactcg gctttaccct gttggttatc gtatggtcac ttgccctagg 2109001 cggaatcgtt tttaaaattt tctttgtgaa acggtttatc ctattgtcaa ccttcgtgta 2109061 tttagtcatg gggtggctga tgattattgc agttaaacct ttatatgctt cactgagcgg 2109121 agcgggattc agcctccttt ttctcggcgg cattttatac tctgtcggaa ccatctttta 2109181 catttggaaa aagatcccct tccatcacgc catttggcac agctttgtat tgggcgggag 2109241 cgctgccatg tttttctgcg tgctcttcta ttgtgtaaag gtgcctttcc tttcgtaaca 2109301 gtaacagaaa agcgcagtct tcacgactgc gcttttttat gcacgtaatt gtttttcatt 2109361 ggcaggtata taagcttttg aaaaggacaa ttcaatgtct gccggtttta agcgtttaaa 2109421 aaacgagcca ttttgcatgt tatctgttcc tttcgtttcc accatcacca acggaagatg 2109481 atagcgggcc gcaagttcta caggatcaat agaaccatct agtgaaagaa tcaggctttg 2109541 tcccttttcc agctgttttg tcacatcttc atataccttt tctgaatccc cgtctgaaat 2109601 cacatccatc cgatccagcc attgcccgat aaaaggcaag cggaacactt ttgggttagc 2109661 gataaagccg gccggttcct caatatatcc agcaattaag gccagttcag ccaaacgcaa 2109721 acggggatgc acatacaaaa caggaccgtg tggtattggc tctggctgat ggatcgtcac 2109781 aactgaaccg gagatgccga tacagccttc taaaaacgcc tttggctgtt cgtacacaag 2109841 agccatctgt tttttgtatg acagacgggg atcgagcatt gtttgattaa ataattgttt 2109901 catatttttt aacagcatat acacaatata aaccactaga aggctgtagc gaaccaatta 2109961 aaatcctccc gctttagaag aattcttttt ttcatacatt agaaattcgt aatcatacgg 2110021 gtttttttcg tctttggtcc cctgctcaga agaaaccagc ttccaattgg attcatcaaa 2110081 ttcaggaaag tgacggtcac cctcaaactc gtgatgaatt ttcgtcatat acagtctgtc 2110141 cgcataaggg aacaggtccg tatagagctg agcccctccg atcacaaagc attcttcagg 2110201 gcctgaacaa atgtccagta catcctttaa tgaactgaca accgtgcatc cctgaaattc 2110261 tgaatccggc gctgaggtaa cgacaatatt tttccgattt ggaagcggac gtccgatcga 2110321 ttcaaatgtt ttccggccca taatgattga atggcccgat gttattttct taaagtatgc 2110381 aagatcattg ggcaaatgcc acggcaaatc attgtctttg ccgataagcc tgttggcatc 2110441 catcgcaaaa atgaatgaaa tcatacgctg accgcccctt ttatatgagg atgcggatca 2110501 taatcctcga tgataaagtc ctcaaatgca aagttaaaaa tagaatcaac ctttctggcg 2110561 aaacgaagct gcggaagcgg tctaacatct ctttccagct gcaaattgac ttgttcaata 2110621 tgattttggt aaatatgaac atcaccaaac gtatggatga actcgcccgg ttcaagccca 2110681 gtcacatgag caatgatcat ggttaggagg gcataagatg caatattaaa cggcacacct 2110741 aagaaaacat cggcagagcg ctgatacagc tgacaggaca gcttgccgtc agacacatag 2110801 aattggaaca ggcaatggca cggcggcaac gccattttat caatttcacc aacattccag 2110861 gcgctgacga ttaagcgtct ggagttcgga tttgttttaa tatcttcaat aagacgggaa 2110921 atttgatcaa tggtttctcc atcagctccc cgccaagaac gccattggga gccatataca 2110981 ggtccaagtt caccgttttc atcagcccac tcattccaga ttcgcactcc gttttcctgc 2111041 agatagcgta cattcgtatc tccttttaag aaccacagca gttcatgcgc aattgattta 2111101 aagtggagtt ttttagtggt gagcatcgga aagccttccc gtaaattaaa tctcatttga 2111161 tatccgaaag tgctgattgt tccggtccca gtccggtctc cctttttctc accatgctct 2111221 aaaacatgtc tgcagaaatc cttatactgt ttcatttttt tcatccttta aaagtagtct 2111281 tctagtagtg taacacaata aaaaatcatt tctgaaccca gaaatgattt ttttatagtc 2111341 agctgacgac aggcttttca tcctgttctt tttcttcatc ttgcagatcc tgatgcgtat 2111401 gtgcaattct gctcgccgct gctgcagcaa gagctgccac aatatcatcc aaaaaggtgt 2111461 gaataccgtc tggactttca tcaagttcct taataattcc aatcttctct ttatccaaat 2111521 aaccgaaatt ggtcaaaccg atcgacccgt acacattaac gattgaaagc gggataattt 2111581 catctatgcc gtaaagcggt tcatccgttt caacaaggtg ctgcagcggt tcggggagaa 2111641 gtttctgttc tgcaagctga tcgagtgcaa ggcctgtcaa aacagcatga ataatttcac 2111701 gtttgttcag gactttttct acattctcca tgcaaacact gagcggcaga tttggattgt 2111761 atttttcctg aagtttttga acaatccgtg caatatcttc tatcataacg ccccgtttgt 2111821 tcagcatatc ctttgttata tcgaccattt cattcattgt gtactttttc atgtctaatg 2111881 gcatctcctt taggcactca tccagttggg aggcgtgttg cggtcccagt aaatgctccc 2111941 aagctcatga tgtgattgaa atccatcttc tgctgtatga taatgaaaat taaaccagta 2112001 gccgtcatga ggcgggtggt ctcttcgcac atggaatctg agaagatctt ctccagttgt 2112061 ccgattgtaa acgttgaaaa ttttttccgt tttgcccgct gaaggcatgc ttgagatcac 2112121 aacatcttgg tacgcctcat catcttgcaa tgtcgctaaa taatcactaa tcacattttc 2112181 gatttttggc aggatctctt tccgatagtc atcctcaatg acaggagcga ttctgctgcc 2112241 gaattttaaa aaggactgat cctcagcgct gtcaaggagc tgttccttgt acgattgaaa 2112301 aagcagttca ggatctcgcc tgtcatccga ctcatcatcg tacaggtcat gctcatcata 2112361 aaaagcggtg taatcattct gctcaagact gctcggctgt ccggaaggct tgtccgccat 2112421 aagggcagcc ggaggagata cgagcccgaa cgttacaatg gtaaataaaa ccacaagggt 2112481 ctttctcatc cacaatttca tgactgctta ttcctctcta ttttattgtc atgtttctct 2112541 tattttagca catccaaaac atgcaagtca tgtactatat gaaactgata tgcaaattag 2112601 gagattcgtt gctatgcact ttgtgtaaaa acgcttacaa tatttcatga aaggaggctt 2112661 tccgcatgat tgacgctctg tttgccacag tttcactctt aacattatta tactttgtcg 2112721 tcatggaggt caccgattaa cagaaagccc gtgatatgaa tcacgggctt gtttgaatga 2112781 cgccataatg gaacagtgct gtttttcttt tcatgacgtt aaaaccaaac tgttcaaacc 2112841 gcgggctttt ccagtggtct tttagcacaa cgctttttct ggcgactcgt accgcttcat 2112901 tgatacatcc ttcgtgcaaa acggaatcct ctgccaaatc acgtaaaggc gcgatgccgt 2112961 cagaggtttc tacaggttca tgaaacattg gatcgaaata aaccacatca acagagttgt 2113021 cagggagctg cttgatgtgt tcaaagcaat caccattctt cacctggatt cttctcatcg 2113081 cagcttgaag ctcttctata cccgtttccc atgaatgcag ccccgtcctc actaaaacag 2113141 acacaagatg gtttttttca atcccaacaa cagaacccgt ttcgcctact gccatacttg 2113201 cgataatggc atctgacccc aacccgagtg tgcaatctaa aaacgtatcc ccttcagata 2113261 agccggcagc ccgaagcata ggttctttct ccccctgtaa gaagcgtttg gctctgaaca 2113321 tcgctgtatt cggatgaaaa aagaatttgg caccttgttt cgtatacagc tcaaaccgct 2113381 ctttgccgac cacaagcaaa tcacgttcag ctgatttcag caggtgctca accgtttgtt 2113441 tattccggcc gcagtatggc atatttagct ctttagaaag ctgctttgca gtttttatgg 2113501 tgtgttcaga cggtctatag cttgttgtta tcatcttctg tactcccaaa aagaaaatgc 2113561 ccggagaacg ggcatttagc agtgcgcatc gaaggcagca gtcagatttt tcatgatttc 2113621 ttccatatcg tgtccttcaa tttcatgacg cggaataaaa tgtacgactt ctttgccttt 2113681 caaaagagcc attgatggtg aagaaggctc ctggccagta aaatactcac gcattttcgc 2113741 agtagcttct ttatcttggc ccgcaaatac agtcaccgta ttgtcaggtg ttttgtcatt 2113801 ctggaggact gcctgtgtag ccgcaggacg cgcaaggcct gccgcgcagc cgcatacaga 2113861 gttaacgact acaagagttg tgccctctgc cttttccata aagttttcta cttcttccgc 2113921 tgttgttaac tcttcaaaac ctgctccagt cagctcgcgg cgcatcggta cgacaagctg 2113981 gcgcatgtat tcttcataag ccattgacat aaaaaaagcc ccctctagta tccttcatct 2114041 gaagtaaagg atactataga gagggccgga tttcaaatgt tcacgcctta aaataaaaga 2114101 aagtgtcccc agctatctag attttcataa taccgccggt gttggcactt gtcacaagtt 2114161 tagaataacg tgccaggtag ccggttttca ctttcggttc aaaacctttc cagttcgctt 2114221 ttcgtttttc ccactcttct tctggcactt gtacatccaa gatgcgtttt tcaatatcaa 2114281 cgataatatg gtctccgttt tcaacaaagg caagcggccc gccctcagcg gcctcaggtg 2114341 atacgtggcc gattgagagg ccacgggagg ctccggaaaa acgtccgtcc gtaatcaatg 2114401 ccacttttgg cccgagtccc attccaacga tttgggatgt tggcgccagc atttccggca 2114461 tgccaggtcc gccttttggc ccttcgtatc tgatgatgac aacgtcgcct tcttttactt 2114521 ttcggttgat aatgccgtca agcgcctcgt cctgagaatc gaatacgaca gccggccctt 2114581 cgtgtcttgt aatcccattc tgtacgccgc ctgttttaat gatagcgccg tccggagcta 2114641 gattaccgaa taaaacagca aggcctccct tttcagtgaa tggttgatcc agcgggtgaa 2114701 tgacgtcata atcctttact tcatgtccgg caatggtttc tccaagagtt tttcctgtaa 2114761 cagtcagcgc atctaaatga agcgctcctt ctttcttcga aagctcattc agagccgctg 2114821 aaacgccgcc cgcttcgtga agatcttcaa taaacacatc cgatgcaggc gccagcttag 2114881 ccaagtgcgg cacgcgctca gcgacttcgt taatgcgttc taaagagtat tcaacgccgg 2114941 cttcgtttgc aagggcaagg gtatgaagaa cggtatttgt agaacctccg agcgccatat 2115001 cgagtgcaaa cgcgttatca atcgctttta ctgtaacaat atcacgcggt ttgatatctt 2115061 tgcgaatcgt ttccattaat tgcgcagccg attttctcac aaactctttg cgttccggag 2115121 atgttgccag aatggttcca ttacccggca aagcaagacc aagtgcttct gacagacagt 2115181 tcattgagtt cgccgtaaac atgcctgagc aagacccgca cgttgggcat ccgaactgct 2115241 ctagttcttg aagctcgttt tcgttgattt tccctgcttg gtaggcgcct accccttcga 2115301 atactgagga aagggagatt tttcgcccgt cacttgttct tcctgccgcc atcggtccgc 2115361 cgctgacaaa aatcgtcgga atgttgatgc gcattgccgc cataagcatt cccggtgtga 2115421 ttttgtcgca gttcggaata cagaccattc cgtcaaacca gtgtgcggat acaaccgttt 2115481 ccacagagtc tgcgataatt tcacggcttg gcagcgaata tctcataccg atatgcccca 2115541 ttgcgatgcc atcatctacc ccaatggtat taaattcaaa cggaacgccc cctgcttctc 2115601 tgattgcttc ttttacgatt ttcccaaact cctgcaagtg aacatgaccg ggaacgatat 2115661 caatgtatga attacacacc gcaataaacg gcttgccgaa atcctcttct tttacccctg 2115721 ctgcacgaag caaactgcgg tgcggagctc tatcgattcc ttgtgtgatc atattactgc 2115781 gtaattctgc catggtgatc ctcctaaatt ctttcaattg tttgattgga ttttattttg 2115841 acaattttca gtttatttat gggctgtttt tgcaaataag ataaatacag gccgccctca 2115901 ccttgttttg ttctttcgtg tttttatatt tatatagctt tctttcgatt tgaaccctcc 2115961 aactattaat attgttactt actataaata gttttcggat atttttcaac aatattcgaa 2116021 ataattttta taaaaagtga attcacataa aaaaggtgca tgatctgcac cttttttatc 2116081 tttattcgcc tttttttctg ctttccgtca tttgtttcca aacagaacct tttgcttctt 2116141 ctccatgctc aatacgttca agcgccattt tgacttgaag gctgacctca aattcggggt 2116201 catcttcggc agcgcgcaaa gcttcaattg cactttcatc gccgacttcg tacaggaaca 2116261 tggcggcacg ccagcgaaca agcttgctgg agtcgcttaa tgacttgatc atagcaggaa 2116321 tggcttgagg atcgccgata tcagacaggc agtctccggc cgttcttctg actgatacag 2116381 ctttgtcctc aagtgcttta tacaatagag gaagaacatc aggtgtttca atcattccta 2116441 agtacacaac agcctgtctt ctgatggaca cctttggatc atccaatgcc ttctgtaaaa 2116501 ccgggatatc ctcttctttc ggatccatct gttccaagtg tgcataacgc tttttccagt 2116561 cctcatcatc cagcatatca agcgttactt tatacgcttt gcgctgtaca gcttgttttg 2116621 cttcgccctt tccttgagcg gctgcttcag tcagtcgttt cagccgttca tcactgtatg 2116681 ccgcttgaag ctcttctgtc acatcatggc cgatttcatc aaagtcaccg aatctgacac 2116741 cttgttcttt ccaagcccgc tcaaacacaa cattggaagc ttcagatcta agttttaaga 2116801 tcgcctgctg aaagcgttca ggtaagccga agcgttcttc ccgctctcca tcggttaatt 2116861 taacttgcat aggaatgccg ctgaacatct gcacaaaaac ttttacctct ccaaaagatt 2116921 cttgatcaga acgattttct tctgcgcttt cagcactttc catcccaaat gcagtgcgga 2116981 cttgcggtaa aatgtctttc cagtcgtatc ttgcattccg ttcaacagca agaaaatctg 2117041 cgacgtgata taccccttta actccatcta ttttaaggat ttccgctata acaagcggtg 2117101 cgccttctgc ttgctcaggt ttatagttat tgcttttgcc cgccggaagc tcttccgtta 2117161 agatgacttt cattgtattc gggcttggtg taggttcaat tgattttatc ttcatgatcg 2117221 tcctcctata gcatatctgt gacttattct atcatagtcg ctccaagcct tctattacga 2117281 cgtttcggca tcaatcccgg gtatgtcttt ttctaattgg cggacaaatt gaagcataaa 2117341 attgtgtctt tcttctgcca gttcccgtgc agtgtctgta ttcatcatat ctttcagccg 2117401 cagcagctta tgaaaaaaat gagcgtaggc gctttgctca tctccataaa ggccatgccc 2117461 ttttgcgccc gcaaacatga aagctctcgc aatgccgaca gcaccaatcg catcaagtct 2117521 gtcagcatcc tgtacagctt ttccttcaat tgagagcggc tccttcgcca atttccccct 2117581 gtcccgaaag gacatccttg ttataatatg aatcaccctg tcagcattct cttttcctac 2117641 tccgaaaaaa acgagctgat catatacttc gctcacagaa agcctgaccg tgtcaggcag 2117701 cttcacatca attaaatcat gaaccaaagc cgccgtttca acaatgaaca aatccgcttt 2117761 ttccttttct ccaatatacg ctgcaagatc tgctactctt gatacatgat gccagtcatg 2117821 tccagagctt tcgtcagtca ggatagattg aacccatgtc ctgatttgct ctgcctgctt 2117881 caattccttc acaaaaacac cctcttttta ttgctctaat agcttcacga tatcgtcttc 2117941 caactctttc ggatttgtat ttggtgaata acggccaacg atttctccat ttctatccac 2118001 tataaatttc gtgaaattcc acttgatcgc cttagttccc agcatccctt tcgcatgttc 2118061 tgtcaaatac acaaacagcg ggtgggcgtt tttcccgttt acatccactt ttgaaaacat 2118121 aggaaatgta acaccgtaat ttgtttcaca aaattcctgt atgtcagcct cttcaccagg 2118181 ctcttggttc atgaattgat tgcaggggaa ccctaagatc tccagcccct cctgctgata 2118241 tgtatcatat aattcctgca gctgcttcaa ttgggaagta aaaccgcact tacttgctgt 2118301 attcacgatc atcagtacct ttcccgcgaa aggctgaagt gtcatgtctt tccctgtgat 2118361 tgtacgtacc ttcatatgat aaatagacat gtaagtccct cctatgtcct tggtgctgat 2118421 tattttacct tttttaaatc gcaattcaaa atgtaaacat caattaagaa ctcataagaa 2118481 acctaacgat atgagcgtca gttcattatc aattcatatg gctcgttttt tatcttatca 2118541 ttctataaaa cattacaatt ccctcttaca tctttgaaaa tcattttact gtgaaaccaa 2118601 aaggcgtgtc agtgcgtttt atttaaagag ttttctgttg tttccccctc aacacgtata 2118661 gatagattga aaattggcgt gaaaattcct ataatgaaga aaattaaacg gggaaataat 2118721 ggaggtggca cgttgcctat taatatacca acacacctgc cggcaaaaca ggtgcttgaa 2118781 agtgaacata tatttgtaat ggatgaaagc agagcatttc atcaggatat ccggccgcaa 2118841 aaaattatta tattaaattt gatgccgaaa aaaatccaaa cagagactca gcttctcaga 2118901 ttgcttggaa attcgccttt acaggttcat ttcacatttt taatcccaag cacacacacg 2118961 ccgaaaaata ctgcgagaga acaccttgac gaattttaca cgactttttc caatatccgt 2119021 cacaagaggt ttgacggcat gattatcacc ggtgcgccga tcgagcattt ggcgtttgaa 2119081 gaggtttcat attgggaaga gctcaaggaa atcatggagt ggagcaaaac aaatgtcact 2119141 tcaaccttgc atatttgctg gggtgctcaa gcaggtttgt attaccatta cggtgtggaa 2119201 aaaattcaaa tgccgaaaaa aatcttcggt gtgttcgaac ataccgttct ttcaaaacac 2119261 gaaagattgg taagaggttt tgacgagcta tactacgtgc cgcattcccg gcatacagat 2119321 ataaatatgg aacagcttca agcagtgccc gagttaaaca ttcttaccgc atcaaaggaa 2119381 gccggggttt gcttaattgt gtctaaagac gaaaaacaag tctttttgac agggcaccct 2119441 gaatatgata caaatacgct tcttcaagag tatgaaagag atttggaacg aaacctttct 2119501 actgtcgagg cccctaaaca ttattttgca aaaggcagca acgagccagt gaatcgctgg 2119561 aaagcgcatg ccacattatt gtttatgaat tggctgaatt attacgttta ccaagaaact 2119621 ccttatgaat gggactaatt tttctttttt tagtgatacg ctgagcaaaa aatatgataa 2119681 aatacatctg attcagtctg cgtataacaa aaatttaaaa tactggaatc caaatcattt 2119741 aaaattagct taactttttc actgcattaa taattcgatt atgtatttgt gttatgttta 2119801 tgtatagaca ataactcctt acgatgcatg aagcttgctt gttgttgatt acattgaggt 2119861 gaatttactt gaataccaat aaaagagtat taattttgac tgcaaattac ggaaatggac 2119921 atgtgcaggt agccaaaaca ctttatgaac aatgtgtacg gctcggcttt cagcatgtaa 2119981 cagtttctaa tttgtaccaa gagtcaaatc cgattgtttc agaggtaact caataccttt 2120041 atttaaaaag cttctcaatc gggaaacagt tttatcgttt gttttattac ggagttgaca 2120101 aaatctataa taaacgtaaa ttcaatattt actttaaaat gggtaataaa agattgggcg 2120161 aacttgtcga tgaacatcag cccgatatta ttattaatac atttccgatg atcgtcgtgc 2120221 cggaatacag acgccgaact ggaagagtca ttcctacctt caacgttatg actgattttt 2120281 gtcttcataa aatttgggtt cacgaaaacg tggataaata ttatgtggcg acagattacg 2120341 tgaaggaaaa actgctggag atcggcactc atccaagcaa tgtaaaaatc acaggaattc 2120401 caatcaggcc gcaatttgaa gaatccatgc ctgttggccc gatatataaa aagtacaatc 2120461 tttcaccaaa caaaaaagtg cttctgatca tggcaggtgc tcacggtgta ttaaagaacg 2120521 taaaagagct gtgcgaaaac cttgtcaagg atgaccaagt gcaagtagtt gtcgtgtgcg 2120581 ggaaaaatac ggctttaaaa gaatctttga gtgcgcttga agcggaaaat ggtgacaaat 2120641 taaaagttct gggctatgtg gagcgcattg atgagctatt tcggatcaca gattgcatga 2120701 ttaccaagcc cggcggcatt actttgacag aagccacagc cattggagtg cctgtcattc 2120761 tgtacaaacc cgtgcctggc caggaaaaag aaaatgcaaa cttctttgaa gaccgcggag 2120821 ctgccatcgt tgtgaaccgt catgaagaga ttctcgagtc agtcacttcc cttcttgcag 2120881 atgaagatac cttgcatcgc atgaagaaaa acattaagga ccttcattta gcaaactcct 2120941 ctgaagtgat tttagaggat atcctgaagg aatcagaaat gatgaccgcc aaacaaaaag 2121001 ccaaagtgct atcgtaatgg cgtacttgag agcatacgaa aatcgtgtgc tctttttatt 2121061 tatattcagc catcaataaa agcggttaca tttttttatg gaacttgccc ttcttttgaa 2121121 aaataagccg tttcgcaact tgacgggtgc tcccagatgg tgtatagttg aaccatcatt 2121181 taacaatgaa tcaaagttag atgatgacaa aatttttttt agcacatggg tgctacagta 2121241 ctaggaggaa ttaagcaata tgcaaaacgg taaagtaaaa tggttcaaca acgaaaaagg 2121301 attcggcttc attgaagttg aaggcggaga cgatgtattt gttcacttca cagctatcga 2121361 aggagatgga tacaaatcat tagaagaagg acaagaagtt tcttttgaaa ttgtcgaagg 2121421 taatcgtgga cctcaagctt ctaatgttgt aaaactctaa actcaataca tgatgatgag 2121481 atgacaaata gaggagaggc attcgcctct cctatttgat tttcatctgg atttcaatcg 2121541 ccaaaatgtt ttgtttacac ctctgttcaa tctcttcaac atacttttcc attgatggtt 2121601 ttcctttttt cgcgatatcg gccagttctt ctaaatcact gtatatttct ataaatgttt 2121661 tgtgaaggat caacttcaag tctttatcat ccatagctgc gttccccttc tctatcaaga 2121721 tacctcaaat agtaaaacgg tcctatttat tctggttcaa tagttatatc ggcttatttt 2121781 tattttcttt tctattttgg tacataaatt tcaaaaaaac tctgcaaaat aatggcggag 2121841 gtgttttttg tgacttcaga atttcataat gaggatcaga ccggctttac ggataagcgg 2121901 cagctggaac tagcggtgga aacagcgcag aaaacaacag gagccgcgac gagaggccaa 2121961 agcaaaacat tagtcgactc tgcataccaa gccattgagg atgctagaga actgtcacaa 2122021 tctgaagagc tggcagctct cgatgatcct gaatttgtaa agcagcaaca gcagctgcta 2122081 gatgacagcg agcatcagct ggatgaattc aaagaataaa aaccgcagct tctgcggttt 2122141 ttatttttag tgattggtta agacatctcc gtattgtttc aacttttcac caaccgtaca 2122201 tttattgata caaaatgaat gcgcataagt tttgccaaat tctttgcgaa actgcttctt 2122261 aataaaacag tccttgcaat attcatcgtg cagttctgtc agttctttaa agatcatttt 2122321 cttatccaat atcgtcatct ccgttacggt ctaatttcgt gtggctttct acgaattgat 2122381 gggatagaat ttttttagcg aggccgtcag cttcctgatt gtcttttcgt tgtattgttt 2122441 cgtaggttgg agtaagcttc agcgattcaa ggagtgcttc tattttgtcc agccattcat 2122501 tatgagatgg atcataacaa ggccagctgc cgtcaagctg attcagcaca acaagcgagt 2122561 cccctttgat tgtaattgaa tttctgcttg ccccaagctc tcttacttct cttattgctt 2122621 cataaagcgc tgcgtattca gcttcattat tggttttcag ccggaagctt ttattttttc 2122681 tcaagcgatg ccgggttcct cccaatgaat aatagatgac gatcccgaga ccggccagtt 2122741 cgctctcttt atcgaaactg ccgtcaaaat aaacagtaat gtcatcaggc tcttgagcaa 2122801 gctcctctgt cagcttttcc aattccttca gcgtccagct gccgcctttc tcgtcttcga 2122861 actctagctc cttcatgtat ggaaaacggc caagttctct ggcgaacgta cgtgcctgct 2122921 gtgctgtcag ccagtcttcg ctaaaaaatg agacggatcc cgttcctttt gcttctattt 2122981 tcaaatgcgg tctgagcttc attacaatca ccttaccatt cattagttgc cgggcttatg 2123041 ctataatcaa accaatctta ccccggaaag gaagcttttt catcttgttt aataattcgt 2123101 tttggatctt ttttgcgatc attcatttta tcattgttct tttattttat aaaggatttg 2123161 gcaaaatggg actgtttgtt tggatcggtt ttgcgacagt ctgcgccaac ctccaagtcg 2123221 tcaaaacagt cgaactgttt ggcttaacag cgacactcgg gaatgtgatg tatggcacaa 2123281 tcttttttgc gacagatgtg ctgaatgaaa aatacggacc agctgaagcc agaaaagcgg 2123341 tatggctcgg attctcaacg ctcctgacgc tgacatttgt catgcagggc gtgctgcttt 2123401 tcgaaccggc ttccagcgac atatcacaaa cagcgctgga aacgatcttc ggattccttc 2123461 cgcgagttgc gttaggaagt ctgcttgcct ttatcttcag ccaaacgctg gatgtttatg 2123521 tatattcggc aattagaagg atatttcctt ctgatcggct tttatggctc agaaacggcg 2123581 gcagtacagc agtcagccag ttgtttgata cattcatatt cactgcagtc gcctttctcg 2123641 gcatttatcc ggcagacgtg tggcttcata tttttatttc tacatatttg attaagtttg 2123701 cggtatcttt aatttcattg ccttatgcct atgcagccaa aaaaatgata cctaatgatg 2123761 aaaggagttc ataatgccta cagaaatata tgtagacggc gcaagcgccg gtaatccagg 2123821 gccttccggt atcggcattt ttatcaaaca tgagggaaaa gcagaatctt tctctattcc 2123881 aatcggagtg catacaaacc aggaagcgga atttcttgca ttaattgaag ggatgaagct 2123941 atgtgcaacg cgcgggtatc aatcagtttc ctttcgaacc gattcagata ttgtggaacg 2124001 cgccactgag cttgaaatgg ttaaaaatat aacgtttcaa ccgtttgtag aagagatcat 2124061 ccgattaaaa gcggcattcc ctcttttttt catcaaatgg ataccgggca agcaaaacca 2124121 aaaagccgat cttctggcaa aagaagcgat tcggctgaat gaaaagaatt aaatcttgat 2124181 cattggttca tcctaatggc gaggtgaact aacatgaaaa agaaagataa aggccggctg 2124241 accggcggtg ttactccgca aggcgacctg gaaggcaata cacataatga ccctaaaaca 2124301 gagcttgagg agagagcaaa aaaaagcaat acaaaacgct agagaggatc taaacgatct 2124361 ctctagcgtt cagcttttca agcatacgct caattccttt aatttggtgg cggcgaagca 2124421 tgtcagccgc ctgctccatt tgcaaagtaa ataaagcgtc tttcagtgtg caggccagcg 2124481 gcactgagca atggatttcc gcaagcttcc tcgacatctc caaatcgctt aaaccttgct 2124541 gaatttttcc ctgctgtcct tttggaagaa gagaaagatt ttccaataaa cggtcaatcg 2124601 tttcgtattc acgaatcagt ttgtaggctg ttttttctcc aatgcctttg actccgggat 2124661 agttatcact ggaatcaccc ataagcgctt taatatcaat caaagccttc ggcattacgc 2124721 ctgtttcttc ataaaaagtc tcttttgtat agactttata atttccgatt cctttttgaa 2124781 gcaaagcaac gcttacttta tccgttaaca gctgaagtaa atctctgtcc cctgttacca 2124841 ccgtaatgtc cgcttcattc gcaaataaat cggcaagagt accgatacag tcatccgctt 2124901 catagccggc aaagccaata ttcatgattc caagctctgc ggctgcttcc tttgccaaat 2124961 caaactgcgg aatcagctcc acaggcggcg cgctgcggtt ggccttataa tcttggaaca 2125021 agtcatttcg gtacgttttg ctccccatgt cccagcagca gacgacgtgt gtcggctgga 2125081 atgtttccac agctgtaatc aaatgcttta aaaagccgtt gacgccgttc gtcggcaccc 2125141 cgctgtcatt tatcataaag ttgcgatgta cggccgtggc aaaaaaggcc cggaataaaa 2125201 gagccatgcc gtcaaccagc aatagtttat tattattcat caaataactc ccttttcttt 2125261 cattccttct attttatcat aaagcagccc aaaaataaaa aacagtatct ctttaattag 2125321 agatactgtt tgaatattta tcaatcgttg tgtcttttgt tgctggcgat cagcttttca 2125381 gcttcgcgtc ctgcgtaaga gtcaaaatgg gtttgaaatc cgtttttctt tttggcgttg 2125441 ttattcgcct gtgcatttct gtttccgagc tttgttctgc ccaacatgaa tcccccctta 2125501 cgtcggatgc atatagtata tgcttccggc aggaggttca ctcgcgacag gatcatccag 2125561 cttacatgcg gcttacgtat tctctgacca tttcttttga tacaagccgt cttgtcggga 2125621 cgatgccttt tttagcgagc tgattcattt gctcggtaat ttcattaatt gcatctgtag 2125681 tataaggctc atcgtttctg catttagcaa cagcttcttc aatcgccaat tcacgcatat 2125741 tttcaagacg cataaatgct ttgatatgct cgtgctgttt tgatgaatgt gctgaaattg 2125801 ctttatgtac ctctgacatt aatcgttcat ctcgcttttt tctatttagt ctatcatgac 2125861 ttgaaataca agccaactga attttacatt tttattgtat tgtctgaatt tttccaggag 2125921 atgcacgcct gatacgccat ttcaatctct ttcgcatgtt ccccttccgc atatcctctt 2125981 aaatatgtct ctttttgatc cgttatttgc gcgattgctt tttcacccat atcttcctgt 2126041 aagcgtctga ggtgagcagt gtaatgagat atcaggcttt cttcttcatt ttttatccat 2126101 gcctctgtga ttttcgtaag tttcatccgt acagcttcga taaaggtcgc ttttcctttc 2126161 tgctcaaaaa actgcttcgg tgatttgatc tcttttagtt cctgctcaaa agcacgttct 2126221 tctatttccg gttcaacttc cttcaactgt atgccgttcg aatgctgatc acccgcataa 2126281 acggaaaaat aaccgtcctc gtttaatgtt ttttgaaaat gatccagcca ttcttcattg 2126341 atatgccgtt cgatgaaacc gctcatgcga acatcaagcg ttttgatttc ctgaatatat 2126401 tcaaatagat attcatgtaa ggctgttgtc atcgctttac tgacgttctt tttccaatcc 2126461 ccgttttgca gcccgggatg aaatgccgat tttaataaat catttgcaaa atatgataat 2126521 cgctgtgcaa tgtgatatag ctgctctctt gtatcttttt ttactttttc aatgatggtt 2126581 tttgagttcc gccgtttctc gatatcggcc gctgtccgct caaatgacag cataaggcac 2126641 tgtttctgcg cttccttctc ttctcgggac tgatgctggg attggtgaag ctgaaaaaca 2126701 gtttcgcata gtttgtctgc ctccgaactg agctgcgctg ctgacgcttt ttttacatcc 2126761 acttcgataa accggtctaa gtgttttctt actttcgaga actgattata aaatgactcc 2126821 ggttttccca ccagttcctc cttacttgat acggtaaaga gctgcggctc ataaacccct 2126881 tcttttacaa gctctgcgct gacataatcg gtcactgttt cgagctctgt tttatctttt 2126941 gcaaggtctg cagcattaat aataaaaaac attttatcca tgctgagcga ttctttcaca 2127001 agtccaagct ttcgcaaaaa tgaacggtct ccttttgaaa aagagtgctg ataataagtc 2127061 atataaaaaa atgcatcagc atctttgata tattggaatg ccagttctgt atgccgttta 2127121 ttcatgctgc tcgcgccggg tgtatcaacg atcgtaatcc ctttttcagt gagcgggcat 2127181 gtatagtaga ccgttacctc tttcacagca caggccgttg tttcctctgc tacatacggc 2127241 tttaattcag agagcggaat cgttaatttc ttctgttcct gtatatactg ctgatacttc 2127301 tcgtatgcaa gcaggaaatt gctgatcaat ttcacgtgtt cttcctgcag cctgtttttt 2127361 ttgactgcct tttcccactt ctctgtgaag gaacggcctg ccggctcctt tggtattccg 2127421 gtgagctgca aaatttcagc cgttaagtca tcctctgtct taaacactac attcgctgtt 2127481 ttgtttaagt tgccattgat tggctttgtg atcttgttaa ttgtcgctgt ggttggcgtt 2127541 ggtgaggatg gcagcactct ttcgccgaca agcgcattgg caaatgatga tttccccgag 2127601 ctaaagcctc caaaaagagc gagtgtaaat ttccgttcct caagcctttt caccctttca 2127661 cgaaacgctg aagtttgctt taacaacatg ctgcattcgc ctaaaatgtc agacaaagtg 2127721 taaaagcgtt tgatttggtc ttgaagcggc atttcttgtt ccattttgat ttctgatttc 2127781 ggcatcggct gcgccgtcag ctggcttcgg ccttgtttct gctctggagc cgccactctt 2127841 gttttcttcg atttaaacca ttctgtgtct atatgcattg ggcatgcgga ctcttcttcc 2127901 caaatggccc acaggcgatc ggttttctct cgggcattat tctctaaacg tgcctgttct 2127961 tgaagaaaga caagtttttc tgattcttgg acgagccggt cgttaattgt ttgcacatct 2128021 ttggaaacac gctctttcac catagcggag agcaccttta tgatgtctgc ggcttctctt 2128081 ttcgcctctt tccggatgag ctctgccaag tcttttgtat attgcaatac atattcagag 2128141 gaaaaggctg caccatgctt gaccgcgtgt tcaatgatgc ttatatcaag cggtgtgcga 2128201 taggcctgaa tcagcttttc actttcagcg gtatagacat caaatacctt ggcgagttta 2128261 tgaagcgtgt ctatcatatg ccaatccgct tcggcctctg ttcgttttgc cacatcagag 2128321 aaaaaagcat tccgcctttt atctctttcc tgtgcagttt tcgctttaga aaagaaaaag 2128381 ccggttttaa aggaaggctc ttgtgattct aaaaatgcag ccgccaattc acgcatttca 2128441 aaaggcgtca ggttggcgtt ttttaaaata cgattgattt cttcctgcat cctcttctct 2128501 gcctcagtca tttgtttttc ggcctcatcc aattgatcac gcagcgattg gaccagtcca 2128561 gtatggatat taagctgttc agcgaaactc ggagcgcctg tttcgtcttt cttcagcatt 2128621 tccgtatgtt cctttagcag attacggact ttttgttcgg ttaaagcctg catattgctt 2128681 tttgattgct gttctattct gcttaactct tctctcaggg cccccatctg attgaacggg 2128741 tgatccggtt ctgttactga tgtaaaatag agcgcttccc ttgaaatccc ttcattgcaa 2128801 agcatctcct ctacctgcgc ttgatagtct ccaaatttcg tctccgtctc atcatggcgg 2128861 tcaatttgat tgacgataaa atacacattc ggaatgcttt cttttattga tctgagaaac 2128921 tttacatttt cctcagcgtg cacgtgatta tagtgaacga cgtaaaacag cgcatccgct 2128981 tggtgaagaa tagaagcagc cgatagaaaa tgcgcatcat ctgttgaatc tatccctgga 2129041 gtatcaatat acgcaacccc ggaatcgatc tcagtatacc tgtcaaaaat ttcgacgctt 2129101 tcaatctgtt ccccgtcttt acaatattgc tgcaccttgt ctttctggta agtcccttcc 2129161 agctcagcac acgctccgtc tgttgtatga agccgaactc gcttttcccc gtttctgatc 2129221 acaacaaggt tagcgcttgt cggaatcggg cttgtcggca aaatattctc cattaacagg 2129281 cagttcagca gtgacgattt ccccgctgaa taatgcccgg taaacgcgat ataaacctct 2129341 tcatcagccg cttttttcat gaccgcagcc agtttagcag ccctttgttc atcttgattc 2129401 tcaataaatt gcttataaag ttccccggtt ttatgcaaaa gctcttttct gttttgatct 2129461 gtcataagtc tgaacccctt tgtgccgttt caattgtgaa cctttttcga aagatctgaa 2129521 ttcattccct tttcatttta cacaagaata aaccaaattt ctttaggaga atagaaaaaa 2129581 gccgccatta cggcagcttc tataaaagaa aatctgcaac ttttacaagt tccagattca 2129641 tcaaacagat ttattagaga ttccttttaa tacaaaacca attaatacac tatatgtaca 2129701 aaccgctcca agcaaaaaca gcattgtcat ttgcttcacc atcctgattg agaatctttt 2129761 tcaaacccat tttaacatgg ttgagaatga ttttcaatcg ctattttacg ctgtattcct 2129821 gtaatgcttt gtcttctgcg cgaattctga cgcttaacaa cacggcattg aaaatggaaa 2129881 acagacacat ggtgacgtat gcttgataaa gcagcggaat cagcaaaatt tcgaggataa 2129941 caacggcata gtttggatgt ttcatccatt tatatggacc tttttttaca agctctacac 2130001 ctggaacaac aaggattttc gtattccaat atgctcctaa ggaacaaagc gcccaatacc 2130061 gtacgatctg tacgcttaaa atcactgcag cgataccgag ccaccagctg gacggctgtt 2130121 tattcatcag cagcacctcg gcaattaagg acaggaaaaa aaggatatgc atcgtaatga 2130181 tatacggata gtggctctcg ccaaattcaa ttgctccttg cttctttacc ttttgttcgt 2130241 tttgcctggc cactgccatt tctgctgctc tttgaacaat gagaatggcg atcaacaacc 2130301 aaaacatgag tcaggccccc ttttcccagc tgaataatag caactctgat gagaaacccg 2130361 gccctaatgc gccaatcagt cctcgttcag cttccttttt atgtccgttc tgcagatggt 2130421 ctttgatcac atacaagatt gtggctgaag acatatttcc gtgcttttgc aaaatgcttt 2130481 gcgcagatga aagcttttct gacgacagcc cgagactttt gatgtatgca tcgatcactt 2130541 tttttccgcc tggatgcgcc aaaaaaacac tgatatcatg gaatgacagc ttatgtttgt 2130601 ccaaaaaaat ctgtacattt gttttgagcc atttttccac caaggtcgga atgtctcgtg 2130661 agaaaatgac tttgaatcct tgatcggtaa agtcccagcc catgacatct tctgattgtt 2130721 tcatcaaaac agattgggcg tccattatct tcggcgcaag cttcagcttt gacaccctgc 2130781 ggtccgcctt ctctccgcat aataaagctg cggcaatgcc gtcaccaaaa agcgaggtgc 2130841 cgatcagatt gctttttgtt ttatcttccg gctggaatgt caggctgcac agctcggcag 2130901 aaatgacaag cacaaaagcc tcaggatacg ctttgcagta ttcggctgca cgcgcaagtc 2130961 cgctggctcc tcctgcacag ccaagccccc aaatcggaat ccgcttcgta tatggagaaa 2131021 acggaagttc attcataagc cgcgcctcga tactcggtgt ggaaagacct gtactggaga 2131081 cgaaaaaaac agcttccact ttctcataag gaatggcttc ttgaaaaaat tccggatgag 2131141 agaggcactc acgaacagcc gctctgctgt gtttaagtgt ttcttctatg tatatttgat 2131201 ttttttcttc aaagctgtgc ccctctttat accattcaat cggcttaaca aactgtctcg 2131261 aatggatttg cccgttttta aaggaggata acagcctgtc aatatcctta aaagaatgct 2131321 gaaacatata gcgggcgaac tcggccgctt tctcttggtt tacattatac gcaggaagac 2131381 ttgttccaat ggataaaata aacgccatgc gatcacctct ttgcatacat tgtgccgcaa 2131441 caatcttttt tatatgcaaa aaaaactccg ccgcggcgga gttagactgc tgttttttgt 2131501 tcagcgaggt cagcttcttg ttctattttt ttagctttag aaaaaacgtt atatacaata 2131561 tttaagacga ctgcagtaaa gctgcccgcc acaatgccat tcgttgtaag cagcgttaag 2131621 gcactcggaa gctgtttgaa aatatccggc acaacggtca caccgagccc caatcccact 2131681 gagcaagcaa caatcagcag attttcctgt ttcgcaaaat caatgcggct gagcatttta 2131741 attccgtaag caatcaccat tccaaacatc gccaccattg caccgcccaa aacagcggat 2131801 ggaataatag tcgtgaaagc agcgatcttt ggaaacagcc caaatgccat taggatcaca 2131861 cctgtgacca caatgacggc attttttttg atccctgtga gctgaacaag cccgacattt 2131921 tgagagaatg ccgtgtaagg aaaagcgtta aaaataccgc ccagaagcac agccagtcct 2131981 tcagctcgat agcctttaga caaatctatc tctgtcaaac ggcggtttgt caggtcacct 2132041 aaagcaaagt aaacaccagt tgactccaca aggctgacaa ttgcaacgat ggacatcgta 2132101 atgataggcg ctgcgtgaaa agacggcgct ccgaagtaaa atggctgaat catttgaaca 2132161 actgccgcgt ccgaaacatt atcaaattga acttttccca taaaatatgc gatgaaggtg 2132221 ccaatcaaaa taccgatcaa aatcgagacg gacttgataa agccttttgt aaaacggtat 2132281 agaagcacaa tgatactcaa cacggtaaaa gcaagtgcaa gattggagag atctccgaaa 2132341 tctgcacttc cttctccgcc ggccatgtta ttcatggcaa ccggcatcag tgtaataccg 2132401 ataatcgtaa caacagagcc tgtcacgacc ggcggaaaaa acgatacgag ctttccaaag 2132461 aaaaatgaaa taagaatgac aagaatgcct gaagcgataa tgctgccgta aactgttgaa 2132521 accccatatt cagatccaat cgctatcatc ggcgatacag ctgtaaaggt acagccaagc 2132581 actaccggaa gcccgatccc aaaaaatcgg ttgctccaca cttgcagaag tgtagccaca 2132641 ccgcacataa aaatatcaat cgatactaag taagtcagct gctcgacagt cagtcccatt 2132701 gcttttccga caatcagagg aacgacaatg gcgccggcat acatggcaag aacatgctga 2132761 atccctaaag acagcgtttt gccgaatcca tttctcatga atgaacctcc tgtacgaagg 2132821 acacttttcc ttcttctaaa gactgaattc ttgccaaaga ttccactcgg tagcccagtt 2132881 ttacaagttc atctcttccc ggctgaaatg acttttcaat aacaatgccg attcccgcaa 2132941 tagaagctcc cgcttgcttc acaatcgaca caagcccgtg cgctgcctgt ccatttgcca 2133001 aaaaatcatc gataatcagc acatgatcct gatccgacag gtgggtccca gacactgcga 2133061 tttggctttc tgtttgcttc gtaaaggaat aaacagacgc tgtcagcaag ttgtcggtga 2133121 gtgttaacga tttatgcttt ctcgcgaaga caactggcac acccagcttc aagcccgtca 2133181 ttacagcggg agcgatacct gatgattcga ttgtcacaat tttggtaata ccgtcttttg 2133241 caaacctaga cgcaaattca tcaccaattc tctgcataag cagcggatca atttggtgat 2133301 tcaaaaaaga atccactttc aatacctgat cagataatac gacgccttct tcctctattt 2133361 tccgtttcag tgcttccatc ctgtctacct ccgttatgag aataaaaaaa gcattgcccg 2133421 ctcaaataaa gagcaagcaa tgctgatatc acaaaaaacc gtacacgtgc ggttccattg 2133481 ctcacccata gtcggacatt tacggtgccc ggtagaaact tgcgtgccat atccacgcga 2133541 ttatatgagt gttcctatta tattgtaata aattatatca agattctaat ctcttgcata 2133601 ggctgaaaat aaaaattccc gaactttaat tttgtttttt tagatatcat tcgtatttca 2133661 aggggattcg atataaaaga gtctgacgac cgcgccgcca ggcttttgat tataacagat 2133721 agagatttga atatttgttt gataaataat caattaaata gcgaacattc agctcttctc 2133781 ctgttgcatc tttaataatg tctaacggct ttttccgttt tccgtgaatg tgcacctttt 2133841 ccgtcagcca ttgctttatc ggatggaact ctcctctttc caagagagcg tcaaattcag 2133901 ggagatcctc aagcattttt tgtttcagct gagccgcata catgtagccg agcgcatagg 2133961 atgggaagta gccgaaatct ccacctgccc aatggacgtc ctgtaaaatc ccctctgcgt 2134021 cggtctgcgg tgtaatccct aaataatcct ggtatttttg attccaaagc gacggcagat 2134081 cttccacaga cacttcattg ctgaaaatcg ctttttcaat ttcataacgg atgatgatat 2134141 gaagaggata cgtcaattca tccgcttcga ccctgataaa tgaaggtttt gattcattga 2134201 ttgcccggac aaaatcatcc agggagatgt ccttgaactg tacaggtgat gcctcttgaa 2134261 tcttcttata gtacggagtc caaaaatgct tgttgcggcc gataaaattc tcgtaaaata 2134321 atgattgcga ttcatgaatt cccatcgatg cgccgtctga caagttcgtg ccactgagtg 2134381 cttcatcaat attttgctcg taaatcgcgt gcccgcactc atgaatggtc ccaaagatcg 2134441 ccgtccggaa atctttttca tcatatctcg tcgtgacccg aacgtctccc cgattcagcg 2134501 tagttgcaaa cggatgaacg gtttcatcaa gtcttccgcc atcaaaatcg tagccaagct 2134561 cctgtaaaaa atacagactg agctcttttt gcttttcttt cgggaacgct tttgtaataa 2134621 agcttgtatc tggtttattt ccggaagctg tcacctgttt aacaagaggg ataatcgctt 2134681 ccttcagctc agcaaacaac tgatcaagca cctttaccgt gacgccgggc tcaaacaaat 2134741 caagcaatgc atcataagga tgctcttgat atccccaata cgtaataaaa cgtttattga 2134801 attcaatcag ctgttctaaa taaggagaaa acaagctgaa atcagatttt cctttcgctt 2134861 cctcccacgc tgtttctgcc tttgaacaca gaatcacgta ttctttgtat tcagcctcag 2134921 ggattttctt attctcttca tactcttttt tcgccagttc cactgctttt ttcgtatctt 2134981 ccgacaagtc atcaaatcgt tcatacagga catcgataag ctccttcatt cgatctgatg 2135041 tttggatatt gaatatatct gttgaaagct ggccgatact ttcggcacga tcctctgagc 2135101 catttttcgg cgcgcctgtt ctggagtccc agtgcattaa cgcaactgct tcgctgtaat 2135161 gtgagattct ttttaaaaga tcaaaaaatt ctttttcata tgtatgtatc tccatatcca 2135221 ttccctccct attctagccg ttccattaca ggctaatgga agggggtatg aaagtcaaat 2135281 tgtttgtata aaaggctgcc ggtatgtttt gtggcagcct ttttattcag ttgatcgtca 2135341 tttgattttt tggcggaggt gttctccgct ttttctgctt gattttttta tctacccaca 2135401 ctgttgccag cggggttaag agcgaggtga caataacgct tgtcgcgata attgcagttg 2135461 ccgactcagc aactggcgca aatgaggcat tcgcttccgc taatgcatat ggcacggcta 2135521 cagccgcccc tgccgtagaa gaagcggcca ctcccgcgac accatctccc cgcgcaataa 2135581 aacgatcaag caaaaacaaa gaactgcccg ataaaatgac gacagaaact ccgataaaaa 2135641 tgccgagcag ccctgattgg atcagcattc caaaattcaa ggtattgccg agcgaaaagg 2135701 cgaaaaatgg aatgatcgcc ggcacaacct tgctgaataa gtctctgaga tcatgatcca 2135761 gatttccaag tatacatcca agtaaaaacg ggatgactgt cgctgccagc gtttcccatg 2135821 ggaatgcggc aagtcccgtc acaccaaacg tcaccatggt cataaaagga ccagattctg 2135881 tactgataaa ggcgaaagcg cccgcatcct cttttcttcc catgtgattc atgagcgcca 2135941 aatacagtcc gccgttcgtt tcattcatta ccgcgacaat tgctaaaaca gaaaggcctg 2136001 caaaaaagcc ggattgtatg ccatcgtcag gtataaattg cgctgcgatc acgccgagca 2136061 gcgccgcaaa tccgatcttc cccaataata acgtgattcc ttttcttgcg atatagcctg 2136121 aagaacgaaa atcaatcgtt gctcctacgc aaaagataaa aacacccagt atcggcagcg 2136181 ttccggtaat caaagcaccc gtaaaccctc caaagaactc cgctgttcca ggcgcaaacg 2136241 tgttgagcgc cgctccaaga aatagcggaa taatcatcat tccgccaggt acccgttcaa 2136301 ttgtcgcctt gattttcata ttgtggattc tcccatcctc cggttatgaa aaaacaattc 2136361 cacttacact tggaaaacag cctgcaaatc ctcttttgaa cagctgccca actggctgcc 2136421 gactccgacg gcgccagctc cggctctaag ccaatcaggc acttcagacg gatgtatccc 2136481 gcctgtcgga ataaaggtca cctgcgggaa aggacccgct aaatttttca taaacggaat 2136541 gccaaacaca ccgcttggga acagctttaa tgtcgtaaaa ccgaatgtca gcgcttccat 2136601 aatttcgctc ggagtcaaga cgccggggat ataatgtgtc tttacaaaag atagatgttc 2136661 agcaagatca gctgaaaaac ccggactgac aataaactgc gcgccagcct tagcagcttc 2136721 cccagcttgc tgcgcgctga tgaccgtacc cgcgccaatt aaaatatctt ccctattacg 2136781 gaaggattcg ataatatctg atgccccggg ggtcgtatac gtcacttcaa ctgcacgaat 2136841 ccctttatct aataaactct caatctgctg acaggcctcc tgcttatcct ttgaacgaat 2136901 gactgcaatc agctttgctt ctttcagacg gttttcaacg actttggact ccatattaat 2136961 aatccccttt cttttggtga accgttcttt gagcagataa aaaagaagct aatttctccc 2137021 tggtcggcaa accgtccata tcccccggtg cctgcacttg caaagcgcca atcgcatttc 2137081 ccctttgcac cgcatccttg tacgacaaac cgtctaggat accgctgatt acaccgactg 2137141 caaatccgtc tccggcgccg accgtatcaa ccacccggtc gacccggcag ccttctagaa 2137201 atccttcact tgtccccgtt ttaaagtaag cgccttcttt tccaagttta atagcaacaa 2137261 agctggcacc ttttttcaaa taatagtcgg caatgccttc aggtgttttt tctccggtca 2137321 atagctctcc ctctgcgata cccgggaaaa accagtctgc aagcccagcc agatcattga 2137381 ttgtgtgtac cattgttgct tgatcaggcc aaagcgaagg tcttacatta gggtcgaatg 2137441 aaatggtctt ccctgcgttt ctcatgtcgt tcatgacatg atacgtgaag tctttcatct 2137501 cggctgataa agcaggcgga atacctgtca catgcaaatg gcctgcgcat tgaaaataat 2137561 ctctcggata ttcagctgta gttaatgtgc ttgcagctga gtttttccta tagtaggtaa 2137621 cttgcgggtc gccttctttc acttttgact tcagcagcag cccggtggga ttttcgtcct 2137681 gcgagcggat cacgcgggac acatccactc cctctttttt aagctcttgt aaaataaacg 2137741 ttccgagctg atcattgccg accttgctca tccatcccat tcgaaatccg agtctggcaa 2137801 ggccgcaggc gacattgctt tctgctccgg caagcccttt agaaaaagtg gatacttcat 2137861 gaaggcctcc atactcattt gcataaaaca tggccattga ttccccgaat gtcaccgcat 2137921 caagcttcat ctcttcccaa cctcctctta gttgagggca cctaggatta aagtgacttt 2137981 ctcatgatga cttttgcctc taattcaatg gtttgaggcg ctcctttgtc accttcaatc 2138041 ctttttaata cacgttccat cgccgtcctg cccatatcat gtgacggctg ggcgatcgtt 2138101 gtaatgcctg gaccgatcag tttgtaccac tccgtatcat cgaatcctgc aatccctata 2138161 tcttgaggga tgcgcaggcc aagctcttcc atacagctga tgattttcag cataatcaag 2138221 ccattcaaag ccagaatcgc ttttttttgc tccggcattt ccttgtgaaa agaacgaagc 2138281 tccgccttaa gctgctcctt gtcctttacg tcaatttcat gcaatctgac aagcccgttc 2138341 acattttgaa ccgaagccat ttcctgatac acagctgctc tttctgcacg agggctgata 2138401 gaggaaatcg gttcggtaaa cagcgcgaca tcagtatacc ctttgctgta caccttctga 2138461 agaatctctt ttgtgatcca tctgttgtca gtcgttacgg tatccagttt cagatccggc 2138521 agtttccggt caattaagat tgttggaatt tgctgttcag caaaagcgcg gagtacatcc 2138581 ttgttttccc ctgttgcgtt taaaatcaag ccctcaaccg aatgggcttc tagctttaag 2138641 agcatttccc gctctttttc aggactgtta tctgtgttgc acaccataat gctgtatcca 2138701 tattgatcac aaacctcttc gactcccctg aaagcagcga ccgaaaaagg atttgtaatg 2138761 tcagccacaa caaatccgat taacttgctt ttttttattt tcaaaccttg tgccatttta 2138821 ctcggccgat aattcaattc tgcgattgcc tttttaatgt ttttcacttt ttcaggagaa 2138881 atcgcgtcaa tttttccgtt aatatagcgg gaaactgtcg atttcgaaac tcctgcacat 2138941 tcagctacgt ctttgatggt tgtatggcct gttgttttct ttttcattca agtgctcctg 2139001 tatctcatat atttgaaacc gatttcaaaa ccgttacaac aaaagaatac cataatttta 2139061 aaatttggga agagtttttt taataatatg tcaattcatt attttttcgt tgactctttt 2139121 cactatttat cctaaaattt tctttgaaac cgttaccaaa atattttcat tcaagtgatg 2139181 ctgaaatcct aaccaagggg gaaatataat ggaaaatcgt tattctgtac atcctgaaca 2139241 agtaaaacgc tttacaacag aggagcttcg cagtcatttc ttaatggatt ctttatttac 2139301 agaaaacaaa cttacgatgt attactcaca tgaagaccgg gttgtcatcg gcggagcggc 2139361 tccagggcaa agtgaactga agcttgatgc aggtgatttt ctaaaaacag acttcttttt 2139421 ggaacggcgt gaaatcggga ttattaatgt cggccagcct ggtgccgtta gagtcggcga 2139481 tgatgaatat gtgcttcaaa caaaggattt tctctatatt ggaatgggca atcaggatgt 2139541 atcgttttca agcctgaacg gggaaaaagc gaagttttac ttcgtctccg cttgcgccca 2139601 caaaagctat ccgacacaaa aagccgccct atctgaactg acaccggacc gccttggtga 2139661 tgatgcagcg tctaatgtca gaagtctgta caaagtcatt catcaggatg gcattaaaag 2139721 ctgtcagctg atgatgggaa taacgatgtt agatcaaaac aacaactgga ataccatgcc 2139781 agcacacgtt catgaccgtc ggatggaggc ttatctttat ctggatcttg aaaaggactc 2139841 aaaggtattt catttcatgg gccagccgga cgaaacacgc catcttgttg ttggaaatga 2139901 gcaggctgtc ctttctcccg cttggtctat tcattctggc gcaggaacat caaactatag 2139961 ctttgtgtgg gcgatggctg gagaaaatta cacatttacg gacatggatc tcattccaat 2140021 ggatgggctg aaataagatg ggttatctac atgacgcctt ttcattaaaa ggaaaaacag 2140081 cgctggtgac aggcccggga acagggatcg gtcaaggaat agccaaagcc ctagccgggg 2140141 ctggcgctga tattatcggc acatcacata caagcagtct gtctgaaaca cagcagcttg 2140201 tggaacagga aggccggata tttacatctt ttacattgga catgagcaag ccggaagcga 2140261 taaaggattc tgcagctgag ctgtttgaaa acaggcagat cgacatcctt gtcaataatg 2140321 ccggcattat tcatcgggaa aaagcggaag attttccaga agagaactgg cagcacgtac 2140381 tgaatgtcaa tctaaacagc ctgtttattc tgacacagct tgctggcagg cacatgctga 2140441 aaagaggtca tggaaagatt attaatattg cctctctcct gtcttttcaa ggcggcatcc 2140501 tcgttccggc ttacaccgcg agcaaacacg ctgttgccgg tttgacaaaa tcatttgcaa 2140561 atgagtgggc agcgtcaggt attcaggtca acgcaatcgc cccaggctat atttctactg 2140621 cgaatacaaa gcctattcgg gatgacgaaa agcgaaatga ggacatttta aagagaattc 2140681 ctgccggccg ctggggccaa gcggatgata tcggggggac tgcagtcttt ttggcatcac 2140741 gtgcttcaga ttatgtaaat ggacatattt tagcagttga tggcggctgg ctatcccgct 2140801 gacaaataaa aaagctgacg aacgatcgtc agcttttttc cattacatca tgtgcggttc 2140861 aacaggcaag acctttttga cctcatcaat gatgcgttca ttttctccgc cagcgtaaat 2140921 gtgaatcgag ccgctgtctt gattcgagcg aatcaggcgc ccgatgccct gccgtacacg 2140981 taacaacata tatggcagat caacttcttc gaacggatct tttttcgctc cgttgcgctt 2141041 cgctgtaaat acaggatcgt gtggcgggaa cggtaatgac caaatggtaa cattcttcaa 2141101 tgcgtcaccg ggaatgtcga gtccttccca taagtgaact gaacaaagta ctgtttcttc 2141161 ttcctcttgg aatttctcta ctaagctgct gatttcctca tcaccttcga agaaaattgg 2141221 atacggcagc tcccatgccg ccgacagctc tttaaactcg tttaattctt caaaagaagg 2141281 gaaaagcacc agcgttcttc ctttgtatcg tttgattgtt tcaatcgttt cagccgtttt 2141341 ttgttcagcg tccatatctg tttttgcgta tagattaata ctcatttgct cgtcataatc 2141401 ataaggggaa tcaacagtta atgacaaata atcatgaatc ccaagactgt cggcaatata 2141461 atcaaacgaa ccgccttctg acagcgtagc agaagaaaag atataaggaa ttttcttaga 2141521 aaacactttt tcgccaagta cttctgctac cgttctcggc atcacgacaa aggttgattc 2141581 tgcttccttt ttctccagcc agctgatcgc atccttttga tatagagata atgaatacgc 2141641 catttgttca acatattctt ccactactga cagttcgtat tgatcaatcg tatacatttc 2141701 agactcaaat acaagtgcct caccgatttt atcaagtaaa cggcaaagct cgtccgccgc 2141761 ctttttgaca cgatggtcat tttttatttc taaacggtgt gaaccggcta cttcctttga 2141821 ttcttcagaa agaacataga aaaattcgtc gtttgcgaga agcgcatctt caatcaattc 2141881 tgcaaactct tctctgatgt cattttgcag caatcgttct aaaaacaatt caagagtaga 2141941 ctgcttcact ctataggtta gcgctttttg cgcagcaaac tctaacaagt gcccctcatc 2142001 aaatacaact gcactatgat caggcaagag cggcagctgg ccctctcgtt tgcgtgattc 2142061 ttccgtccac acatgctcca tataaaaatc atgggaacaa atgattaagt ccgttgactt 2142121 gcggtagtaa tctctggaaa gtgtcagacc gcatctgtgt ctcatatcac aagtcagaca 2142181 gtcctgaaac gagtcgtagc ttacgtcaga ccactcttca ttcgatagat ttgcgtactg 2142241 cttacggtcg ccatacggat aaaagcgctg catcgcctgg gactcgtgga caaatgacgg 2142301 taacgactca taaagatcca gccatttatc atcatcagaa cgctgcattg ttttttcaag 2142361 cttcttcaag cataaatatt gctcatgtga ttttgacagc cttgtatcaa ttttcagatc 2142421 aagatgctca gccagcttag aaatatcgcc ctcttttttc accagctgtt caattaatgt 2142481 ttcatccgca caagcgatga tggcaggttt gccgacatac cttgcatagc tgattgcaaa 2142541 aagaagatat accagcgttt tccccgttcc cactccagct tcggcgaaca tgactttttt 2142601 ctctttaaac gcccgctcca gctgaaaagc cataaatact tgctcgtccc gaagatcaaa 2142661 ccctttttcg ggaaggatat cgtaaaacac gtcaccaatc caattgttca attcttcata 2142721 aaaattcttt gttttcgtta aagaaaaagg caaacgtgat gttgtcacct agttccaacc 2142781 cccaactatt cgacattcag accaccaata atatcatttt ccgctgatga atacaataaa 2142841 aaacttggca atgccaagtt ttttgcagtt tacttacgat tgatcacatg cgacgataaa 2142901 aaaggatggt ctgttgaata aatatgttct accgcttttt ctaaatcagt ttgcgcatgc 2142961 gaaatcacag acggagacga atcagtcccg agctccttca gctcgtttgc tgttgcgtca 2143021 agcgcccttt gaataagatt aaaatgttcg ctgttcagca tgagatcacc tctgatggaa 2143081 ataatcatca ttgtatgcga acttttcatt ttatatacat gctttaccgc atgttatcac 2143141 cgaaacatgc acaaactaca cttgatattc cgtctccgga ttatccgtct tatcaacaat 2143201 attctatcag ggagtgatgt tgacatgagt tatagaaacc gattagatca gcattctgaa 2143261 ctgtttcatc acaattggac gcggcctaaa cgttcaaagt ctcaagtaaa cggtcacact 2143321 gaaatgtccc aaaccaacat tatattgaga agcaacgcga aagctcaccg ttggtaacga 2143381 tagaataggg ctgaaagatg aaagaagacg catgcagagc gtcttctttt tatgcgtttt 2143441 ctgttttctt gcgctgcggt cttacttttg accagtattg ataataatcc gttttaataa 2143501 acccgttaaa gagttttcgt ttcttcgttg cttttctgcc atatgcttcc tcaaagtttt 2143561 catttgatgt cagcatatac acagaccaag tatcaagcgg ctcgaacgcc tgccccattt 2143621 ctttgtacat ctgctcaacg gcttttttct cgccgagacg ctctccatat ggcgggttgc 2143681 cgacaattac gccaaattcc agatttgtgg taaagtcttt gacctgcatc tgtttgaact 2143741 ggattagatc tcccaatcct gcttcctctg cattttcttt tgcgatttga accatgcggt 2143801 ggtctatgtc gctagcgaaa attgtaagcg gctgatcata atttgccttt tcttcgactt 2143861 caagccgcgc tttgttccac agatctttac cgatccattc ccaatcctct gatacaaaat 2143921 cgcggttgaa tcccggggcg atgttttggc cgattagcgc cgcttctatc gcgattgttc 2143981 cggagccgca gaaaggatca acaaacgggc ggtcaggcgt ccaattggtt aattgcacca 2144041 aagcggcagc aagtgtttct ttaatcggcg caccgccctg atcgacacgg tatcctcgtt 2144101 tgtgaaggcc cgtccctgat gagtccagtg taatcaaagc ctgatctttc aataaagata 2144161 tttccacttt atactcagca cctgtttctt caatccaatc attggctttg ccggactgca 2144221 gcttgagctt ttcgacaatt gcttttttga cgatccgctg acagtcagga acgcttgcaa 2144281 gtgttgattt taccgatttt ccgatgacag ggaatttccc gttttcaggt ataaatgagc 2144341 gccagttaat cgctttcgtt ttttcaaaca gttcatcaaa tgttttcgct ttaaaagaag 2144401 caacctgaac ctttatgcgg tcggctgttc taagccaaag gttcgcacgg cagatggcaa 2144461 gtgcatcacc ttcaaaaata actttcccgt tatcaacctt gcattcgtat cctaaatctc 2144521 gtacttcctt tgcgacaaca gcttcaatgc ccatcggcgc cgttgcaatt agtgtatact 2144581 tcttcatcgt atcaccctgt cttttaaaac ttttctcttt tcaagataaa agctctcctt 2144641 atacgggaga gcttgttttc atcattttaa atgtaagtgg tctaacgttc tgtaagccat 2144701 gttttgttcc atcgtactgc aaacggctca tcacctcgta ctcaggcggc aatcatctat 2144761 ctacagaaag cattctgtcc ttctctccgt tgaattccgt taagaaggtt cccctaccaa 2144821 aatttgggtt tctcgctcga ggggtttacc gcgttccact ctcaccattt ctagtgagac 2144881 ttcgtcactg tggcactttc aaggatactc agccatatcc gaagacgtag gcttttttcc 2144941 tgccgtcagc ctctaaagac tgccctagct tatgacttcg ctaggcacga acactacggg 2145001 catctcagca ccgtgcgagc atggactttc ctctacagat tcaagatctg cagcgattac 2145061 ccgaacgtta agaacatgaa ttattatata acaactgatt acaatttaca agcgccattt 2145121 ttttcaagcg tgatcaatca taaagcttgc tgccaaaaac gtgtttttct aagttagaca 2145181 gccgttttaa aatatcaaag tttgttgtgt tagattgcac aggctgtttt ttgctggctt 2145241 cttcaagctg ttttttcagc tgcagatttt cctgctgcag ttcttcaatt tcttgatgga 2145301 aggtttcata atccttaata atcatatcta aaaatttgtc aacgtcttct tgcttgtagc 2145361 ctctaacgcc tgttttaaat tctttttcca aaatttcttt cgcagaaagc tttactttat 2145421 cagcaagcat ctttttcacc tcgtatcgtg aatcatcaca tatatttttt cagaaatctg 2145481 tacggttgtc aaatttctct ctcattgtta gtagctgtct tcctccactg tcactctcaa 2145541 gtcatccatt gtaataaagt agatgggata gccatcctgt tcgcgccttt tttccgctgt 2145601 cccaagcata tacttagggg agccttcctt ttccgggtca tataaaagca gaagcccgtc 2145661 ggacttatca atgaagaact gatttttttg tttgaattga agcgggcttt cataaggacg 2145721 gtgagtcagg cttgcttcat agtctgcctg agccagaact gcttcatact gttctttatt 2145781 cggttctttc cagttctttt cctgctcgta aaatggtgtg atgacagcta cctttaagtc 2145841 agggtattcc tcctgcaaat catatgcagc ttctgccgcc cacagctcaa ctccaagctg 2145901 gcccgaaatt aaaatccatt ctaatccttc atccaaaaaa gcaatcagcc ggtttttaat 2145961 ggcttttttt atgtaataca gcgccttgtc atcctgctta aatatcccca gttcaaacgg 2146021 tttatagccc gttattgcca atactttcat catttcacct gctttaaaaa atggggctcc 2146081 cgtgggcccc atttgttgtg ctgcattgtt tacaccatca agctgcacgt tttccatact 2146141 agtagtcgca gcaaggtttt cctgcttgaa aatgctgatg cgtagccggg tcaacatttg 2146201 agaaagtgtg tggaaagtag tgaacgtgct gaaaatgctg gtggtttacg tttgttgtat 2146261 gctgtgggtg aatgtgcggc acgatagtct tcgaaaacgt atggtgttca cagcaatgag 2146321 taggatggac aattggcgcc atcatatgcg gtctgcagtg atgcatgata aaatcccctt 2146381 tccataaact ttattacaat actaagttat gaaaaataag gggtacatgt tctgatgcaa 2146441 agacctattt taaaagtgtg caattaagct gtctttaaag tttgaaaaca caaaagcaat 2146501 caaaaatacc acaacaaaga acaagtaaaa aacaccctta tacataccaa ctctcccttt 2146561 aaaaataact aacgtcattt tacaggattc gccgctattc tacaacaaaa tcaatgtgaa 2146621 ttcagcaaaa aaaattcatg gcgaaacaag tcgtcttttg cgctttcccg gggaatattt 2146681 aagaggaata tttcctcttt agccgggcaa ttctcacatg cagtttttca gtttctttct 2146741 ctgataagca tgccgcatcg ctaagcgatt gctctgctac ttgcaatgct tttccgaatt 2146801 cttttttctt atgctcaaaa tatttcgcga gctctattac agcagcgtat ctgcacttct 2146861 ggttttgcga gcgggacagc ttttcccaaa gcggcactgc ttcttccaag cggttttgtt 2146921 ttttgtacag gagcgataaa tccagccgtg cactgtcctg gtcctcaaac gatttttcta 2146981 taagcctttc caactgcttg atcgcttggt ccgtttcttt atgagccata aaccatttcg 2147041 ccatagcata ggcttcactg tgttcttttg gcgcatgtga ttctgaaagg atttttttag 2147101 acatatggat gtacaatgaa atgagtgata acacatccat ttcattatga tgcaggacac 2147161 cttttaaaag atccggctct tgcgccttga taaaatgaaa gtaaagcatt ggcgccaagt 2147221 agcccggtgt gtcttctagc ctgcggatgc cgagctcctc tttttcaacc gtgccaagag 2147281 atacacggtc cattttgtgt ttccacaggc gtctagctcc atgcaaaaga tcaaagtggc 2147341 caaactccgg aagcttcgga agtctgtcac ggatcaaggt gtgccttgtt ttcacctgcg 2147401 gccaatcaaa ggctttgccg ttgtaggtca caagtgatgt aatgtcaacc tcgcttaaaa 2147461 agctttggta caaggcgact tcgttccccg gtttgggcaa aagatgctgt ttgactgtca 2147521 ctcggtcttc atatactctc gcatgcccaa gcaaaaaaat ggtattccca gctccacccc 2147581 caagaccggt tgtttctgta tcaaagaaaa agaggttgtt tttgttatac ccttttgctg 2147641 acaatgtatg cgacaggccg ctttgattcc acagtgtgat cacttcctca agctcagaaa 2147701 agctgtataa cccatggcgg tgagaaagcg gatattctac ttctctgatg aggcaatatt 2147761 catcttcgaa gatgaaaggc ttcatgccaa aagcctccca ctcttctaaa aacgggatgt 2147821 catcaaagtg gttttcttgt ttgcctgctt ctattttttg ttctccttcg tcgagcgcca 2147881 tgtgcttttt catccgttgg agtttccctt ttaatgacat atccggcctc cctccttacg 2147941 acatttgatc caacagctgc aaaattcttt cctttgcttt tatcccttct atttccgtac 2148001 ctatacaaga cggacagccg tcatgacaag gacaatgtgt aatcagttgt ttcgccgctt 2148061 cattaatgtc tgaaaaacgt ttaaagactt cctccgccaa accgataccg cccggataat 2148121 gatcatataa aaatatggtt ggcaatccgg tatgggctgc tttaatttga gaaacaacat 2148181 gaacatcatt tcgatcacac atgatataca cagggacaat atgctgcagc acattcgaga 2148241 tgccaagaag cagctgttcc agtgtctttt ccccgatgtc ttcatccgct gttttgattt 2148301 cgagccaagc tgcacttgta tgcagttctt cttccggcaa atgaataggt ccagacccaa 2148361 tattttcaaa agtggtcatt tttatttttt taaaaatggt cggcagggca ttgacagtga 2148421 cgtctccgta gtgcaatgac gtacggcttt tttctttcgt tttatcgatt tctaatacct 2148481 tcagctgaac tgccaggttt gcatccgtat aatattcgac atcgactttt ctgacatacg 2148541 cctttttatg gtcccaatcg agcttctcaa cttgatactg aacgccttca tgcaaataaa 2148601 tcgcttcatc atgcaaaagc gtcatcgcac taaaacggtc catttcaccg ataatcctta 2148661 catttgcaat atccgactga tcaactataa cgacattttc ctgggaggcg gaacgcaaac 2148721 tgatgtttga cgcagggaac gactcacttg cccaatggta ccgttcgccg ttgcggtgaa 2148781 gaacagcctc ttcctgaaga tactcaagaa tatcactgac ttccatggct ccaaattctt 2148841 catcagctct aaaaggaagc tcataagccg cacactttaa gtggtctact aaaataatca 2148901 aattctccgg attgattctt gcagattccg gcgaacgatt aaagaaatat tcaggatgcc 2148961 gcacaatata ttggtcaatc ggtgttgaat tggctaccat gataatcaaa gattcaccgt 2149021 gtcttctgcc ggctcgtccc gcctgctgcc aagcacttgc aacacttccg ggataccccg 2149081 tcattacaca cacttgcagc tggccgatat caacaccaag ctctaaggca ttcgtactga 2149141 ccactcctaa aatgtcgcct tctctcagtc ctctttcgat ttctcttcgc tctttcggca 2149201 gatagcctcc ccgatagcct ctgattgatt ttgttccaat ctcttttttc acaagctcct 2149261 gaatatggct taaaataatt tccacccgaa ctctgcttct ggcaaaaaca atggtctgca 2149321 ctttgttttt aaggaactct ttcgccagtt cattcacttc tgcggttgcg ctccttctaa 2149381 tattcagcgg tttgttcaca attggcggat tgtaaaacac aaaatgcttg cgtccgctcg 2149441 gtgcgccgtt gtcatcgacc agccgcatcg gtttgcctgt cagctgctct cccaattcct 2149501 ttgggttggc aatcgttgcg gaagtacaaa taaaaactgg atcacttcca taaaaccggc 2149561 agatccgctt cagccgccgg atcacatttg ccacatggct gccgaacaca cctcgatacg 2149621 tatgaagctc atcgatgacg atatacttaa ggttttcaaa caaactgacc catttcgtat 2149681 gatgcggtag aatggcagaa tgcagcatat cggggtttgt aatgacaata tgacctgctt 2149741 ttctcacctt ttgtctgatt gccggagacg tatccccgtc atatgtaaag cttttaatat 2149801 caatgcccat ttcatcaata atttcattta gctcgctctt ttggtcttgt gccagcgctt 2149861 tagtcggaaa taaatataac gcccggtttg tttcatcttg ggcgatggac tgcaggactg 2149921 ggaggttgta gcataacgtt tttcctgatg ctgttggcgt tacggtaacg atgctctctc 2149981 ctttttgcac atattgaaaa gcggaatatt ggtgagtata tagttcatca atgccccttt 2150041 tcgaaagggc cgctttgatt ctctcgtcta tactttcggg cataggcctt gtttttgctt 2150101 cccgaggctc aatttcatgc caattcacaa cgttttcatt tccttttaaa tcagaaatga 2150161 gttcagtcag tgatttcttt ttcattcttt acacctcttt gtcaagtaca gtttaccgaa 2150221 tatttgtttg catggctagg tgcaaatttt atacagttga ataaaaaaag caaggcatac 2150281 gccctgctta tttcgctttt attgtaaaga gctttgattc gcctttacga gcagcctttt 2150341 cgcctgccga taccattgat cctacagcct caccattcat tataacgatt gggatgactg 2150401 tgctgctcgc tttttctttt attaattcca aatcacatgt aatcagcggg tcaccgacct 2150461 tcactttatc cccttcttta atgtgggcag taaatccttc tccgttcata ttgactgtct 2150521 ccagcccgac atgaattaac agctcaattc ccgagcgagt ccgaatgcca acggcgtgtt 2150581 tggtgtggaa aatctgaatg acttcacctt cagcgggaga aacgatttca ccgctagaag 2150641 gttccaccgc tattccttct cccatcattt tctgtgaaaa aacagggtcc ggtacatctg 2150701 acaggtccat tactgtaccg tctgccggag aataaataac ctcttctgtc accttttcct 2150761 gaattttgcc cattccgaat aattttttca gcaatgtatt ttctcccttc tcattcactt 2150821 caaccgttat cccttcattc accactattt aaccacactt tcaattttgc ttcaatttat 2150881 aacaacatct ggcatagacg cataatctgg ttaaaaaagg cggtggcgat attggaattc 2150941 catgatgaca aaaagaacga actgcaaaag aaagaagaaa tcataacgga ggcaatcgac 2151001 actctttttc aatcctcagc gttcggcaac cttataaacg gatttcagaa cctaatcaac 2151061 tcgagtttaa aggatgtgca gacgaccata catgtcagag aaagagatac tgggctgtat 2151121 atcgatatta ccattccggc gacgtttcga gatggcgaga tcgtcgttga tgttaaatcg 2151181 aggtatctcc atgtaacact ccaagaaaaa cagaaacacc aaaatgaggc tacctttaca 2151241 agcatgacaa gaacggttca gctgccttat gaagttcgcc aagaagatat ggaaacgtct 2151301 tggaacgagc agacaatgac acttttcttt ccaaaaaata agcatgaatg aacgattcat 2151361 tcatgcttct atcatttaaa aaagctggta aatcccttta ttaaagatcc gacctgattc 2151421 attgcactca ttacttgacc tgtcgtatcc atcattttat taaaatcaaa ttgcccattg 2151481 gcttttttga actgcgacat aatgctttga aattgtgaag gctgctgttg attaggcctt 2151541 gggataggat aagggttaga aaatacaggc ggctgcatag gcataggctg gatcggagca 2151601 taaggctgat aataatcctg ctgtccataa tgctgctgag gcagttgttg ctctaaataa 2151661 ccgggtgcag cctgctgata atatccttgc atatgctgag gataataata gcccatttgc 2151721 cgaggatagc ttcgagagct cccgttcatt gcgattcccc cctaaacaca acatatttct 2151781 cttctatata tgtatgaatg acttctattg tttgtgtcac aagtgatgat tagcatttgt 2151841 caaattgtgt cgaaagttta aattttttaa aaacagaaaa aagtcgaatc attatggtac 2151901 catattttca atacagatga gaggggatgc accataatga acgtatcata cttaagcaaa 2151961 cgttttgcag aaatgaagaa atatgaaaca gactgtatga ataaactgat ggactttgcc 2152021 aagttcctct atattcaagg acatctcagc ataactgagt ttcgtaacag tatgaaggtt 2152081 ctcgaagcaa atggagcaga aagcccggca tatgagatga attaacgtcc ggccccctat 2152141 aaaaacgaaa agaagacagc cttttaccgg ctgtcttctc ttgcaatttc atcctttact 2152201 gcgtgcaatg tataaaggac tgactcagtg atgtccttga atcgtttttt atgaatatga 2152261 tgaacataag attgaaggac caattccagg aaattatcct ttacggcctc aatttgctct 2152321 ttatgcacat attttggccg gcggactttt atcaattcaa gagcaccctc tgcccagcga 2152381 gcagccagtt catcattctc ttcaactgca ggctttatcg tctcaaaaaa atcataagaa 2152441 tgattactgt tttttccttc ctgataccga tcagcgcctt tttcagcaac ttcaatcatt 2152501 tgctcggtca tttccagcaa agtttgtgat agcaatatct ttcacctcaa tgcctatcgt 2152561 accaaatttc actcacaaat tcagccgatg cggtatacct tctcaaacgc atacctgtgt 2152621 tcaggcgatt gatacagctc atttatacaa atatgaagat ctatgatttc ttcttcgagc 2152681 acacttaggc gatcgttctc cgtttcccgc atctcagcct ctaatgcatt tacagaatga 2152741 ttcaggcttt gctcagctcg cgttaattca tcttctatat cagaaagcat acggagaata 2152801 tctgtcttgc atacataacc ggacattcgt gtacctccct ttccttgtct ctcccggtta 2152861 acattctttg ctctcaaggc tctttccttc ctcatgacaa aactagaagc aaatcgccaa 2152921 acaaacaggt attccacgaa aagctgaagt tttcgacaaa aacacccgca aaaattgtat 2152981 gatcctcctc attaatgcaa acgatacttg tgaggaggtg ccgtatgaaa acaagaccga 2153041 aaaaagccgg ccagcaaaaa aagactgaat caaaggcaat cgattcttta gataaaaaat 2153101 taggcggccc gaaccgccct tctacgtaag aagcaaggaa tttccttgct tctttatttt 2153161 ttcagccact gctccaccgc aaaaagcgca tgaagctggc gctttttatg taaataccag 2153221 tctgtcaatt caatctgctt cggcaattcc tcgcgcctaa agaacgtttt ctttatcttt 2153281 ccatgaaacc aatctgtttt cgttccgtct aatgagtgga ttaactcagg gtagcatgtc 2153341 cttagcatag gagatgttct ttttgtaatc ccgatcatct tttccatatc aaaacgggaa 2153401 cctgtgtgcg gcactgtgtg caaaaagtga taaaaagagg agaacaattc tggcttgaac 2153461 agcaattgag acagctgctt tcccagcctt atcctttcct ccgcctttga aaagcgtttc 2153521 actgaaatgc cgtaaaaaaa cccatttgag gaaggaaaaa taacggtgtt aaaatgaaac 2153581 cagtcactta aataaaaagg aatcgtgtca aaaacattct ttttaaacga aggattttgt 2153641 ataataggtg tttggatagt gttttgttca tttataatga gggcatacat tagccgctcc 2153701 gtatttcgct catgccaaaa acgggtccat tcttccgaca taaattgtga gacgccaaac 2153761 acatgcagca gatgaaacag cggtttccca actctttttg accagtggta taaaagaagc 2153821 tgcggatagg catccgaaaa aataagccag ttcgctcttt cataggctaa aaagaaccat 2153881 ttttgctgtc tctcacggag tccaagctga aacagactgc cttttaagtc agtcattgac 2153941 cagccggcat tacgagaaac gaaagaagcc aaaagcgacc atttgatttc cggatgacgg 2154001 tcgtaaaatg ctttataagc atttgttctt gaaatgttat ccgcgttttt catttttgtc 2154061 tgccgctcaa tccggctcag aagctttctg atggcctgtt gttcttgcac gttcattcac 2154121 ttccgtcatg attagtttaa taaggaggat gagaaagtga ttcggtatcc taatggaaaa 2154181 acatttcagc cgaaacattc ggtttcatcc caaaacagtc agaaaagggc cccgtcttac 2154241 agtaatcgcg gaatgaccct cgaagatgac ttaaacgaaa cgaataagta ttatctgaca 2154301 aaccaaattg ccgttataca caaaaagccg acacctgttc aaattgtaaa tgtccattat 2154361 ccaaaaagaa gtgccgcagt gattaaagaa gcttacttta aacaatcatc gacaacagac 2154421 tacaatggga tttacaaagg gcggtatatt gattttgagg cgaaagaaac gaaaaacaag 2154481 acctctttcc ccctgcagaa ttttcatgac catcaaatcg agcatatgaa gcaggtaaag 2154541 gctcaagacg gtatttgttt tgttattata tccgctttcg accaggttta ttttttggaa 2154601 gccgataagc tgttttattt ctgggacaga aaagaaaaaa acggcagaaa atcaattcga 2154661 aaagatgagt tggaagaaac agcttatccg atttctcttg gatacgcacc cagaattgat 2154721 tatattagta ttattgaaca gctttatttt tcgccatcat ctggtgcgaa aggttgatta 2154781 acgaaaggtt gagatgttat gtcagatcaa tttaacagcc gtgaagctcg acgaaaagcg 2154841 aacagcaaat cgagtccttc accgaaaaaa ggcaagaaac gaaaaaaggg cggattgttt 2154901 aaaaagaccc ttttcacttt actcattctg tttgttttag gcgtagtcgg cggtgctgtt 2154961 acatttgccg tcatggtttc tgatgcgccg tcccttgatg aaagcaaatt gaagacgcct 2155021 tattcatcaa cgatttatga taaaaatgga aaagagatcg ccgaagtcgg cgccgaaaaa 2155081 cggacctacg tctcgataga tgaaattccc gatgttgtaa aagaagcctt tatcgcgaca 2155141 gaagacgctc gtttttatga gcaccacggg attgaccctg tccgtatcgg cggtgcatta 2155201 gttgccaact ttaaagacgg cttcggggct gaaggcggaa gtacgatcac ccagcaggtc 2155261 gtcaaaaact cccttctttc acatcagaag acgttgaaac ggaaggtgca ggaagtatgg 2155321 ctttcgattc agctggagcg caattactct aaagatgaaa ttttagaaat gtatttaaac 2155381 cggatttatt tttctcctag agcatacgga atcggaaaag cggcggaaga atttttcggc 2155441 gttactgatt taagcaaatt gactgtcgaa caggctgcga cgcttgcagg aatgccgcag 2155501 agcccaacag cgtacaaccc ggtcaaaaac ccggataaag cggaaaaacg acggaacatc 2155561 gtactcagtc tgatgaaaaa gcaaggattt atttctgatt ctcaatataa caaagcgaaa 2155621 aaagtggcag tgaaagacga aggcgtcgtg tcacagaagg aatatgaaaa agcaagtaca 2155681 aacaaataca gcgcatttgt tgaagaggtt atgaaggaaa ttgatgaaaa atctgatgtc 2155741 gatccatctg ctgacggatt aaagatctat acgacattag atacaaaagc acaagataaa 2155801 ctagatgaat taatggacgg agacaccgtc ggatttactg aaggcatgca gggcggtgtg 2155861 acgcttctcg ataccaaaaa cggagaagtc cgagcgattg gtgcgggacg caatcagcct 2155921 gtcggaggct ttaactatgc tactcaaact aaggcacagc ctggttcgac cataaaaccg 2155981 attttggact acggaccagt tattgaaaat aagaaatggt ccacatacga acaaattgat 2156041 gactcagctt atacgtattc taacggaaaa ccgattcgtg attgggaccg caaatatcta 2156101 gggcctatct caatgcgtta cgctctggcc caatcaagaa atatacctgc tttaaaagca 2156161 ttccaggcag tcggtaaaga tactgctgta gactttgcaa atggactcgg gcttggttta 2156221 acaaaagata atgtaacaga ggcctattct attggcggtt tcggtgggaa cgatggtgtt 2156281 tctcctctga caatggcagg tgcatacagc gcgtttggaa ataacggaac gtataatgaa 2156341 ccgcattttg taaaatctat cgaatttaac gatggcacga agcttgactt aacaccaaaa 2156401 tcaaaatcag ccatgagtga ttatactgcg tttatgatta cagatatgct gaaaacagct 2156461 gtgaagacag gtactggaca gcttgcacaa gtacctggtg tagaagttgc aggaaaaaca 2156521 ggaacgacta actttgatga taatgaagtc aaaaggtaca atatcgctag cggtggcgcc 2156581 cgagattctt ggttcgttgg ctacacaccg caatatacag ctgccgtctg gacgggaatg 2156641 ggagaaaacg aggctggaaa gaaatcactt tcagctgaag agcaaaaagt tgcaaagcgc 2156701 atcttcgccc agctcatcgc cgatgtcgat gacggaagcg gatcatttga gaagcctgac 2156761 agcgtagtgg aagccaccgt agaaaaaggt tctaatccgg caaaactggc agggccaaat 2156821 acgccaagcg ataagaagct cacagagtac tttgttaaag gcacagctcc ttctactgtt 2156881 tctaaaacat atgagaaaga agaaaaagag gaaacagcta aactgtctgg tttaaacgtg 2156941 aaatacgata aagacaatca atctttaacg ttaagctgga attacgacgg agatgcgacc 2157001 tttgctgtta agcaatctgt tgacggcggc agctactcgg aaattcaaaa cagctctgca 2157061 aaagaggcag ttatttcggg tgtgcagcca ggatctgtat acaaattcga agtaacagcc 2157121 gtcagtgatg atggcaaaag tacagcttcc acatcttatg aggtgccaaa agctgaagac 2157181 gatgaagata aaaaagacca gcaacaaacg gatgatgaaa aacaagatga tgagaagact 2157241 caggatgata cacaaactga tgattctcaa aaagatgacg gtcagacgga tcaagatcag 2157301 acagatgatt caacaaacga tcaagacaaa aaacaagaca atacgaacac caatccgtcc 2157361 gacaacaata accaagacca atcaaacgat aatgataacg acaacagtaa caaccaggat 2157421 acgtcggatg gtgattcgaa ctctggtaag aatgattcaa caggttctga cacgaataaa 2157481 aataaaacag acacatctaa taaaacacaa acaaactcat catccattga aaaaacaaat 2157541 taaacaaaaa agccgtcacc tttggggtga tggctttttt ggtacacaat aaaaaacctc 2157601 ccgttttaac aggaggtttt atcgattcat cgcatgatat ttataaaaat gctttttcat 2157661 ttcggtaatc agctcatcaa gctgaataaa gcaatggtat tgggtcggct taagaagaat 2157721 aaattccact cgttcagccc aattaatcgg ctttgcggga tatgatttct ccctcagttc 2157781 ttgccaatcg agcgatttca ccggctcacc tgctgtccaa tgtaacgaag ccagcaaaca 2157841 cacaatgccc tttaacattt cgttttggtc acatctcgat tttcgtgttt gaaagactgg 2157901 gagaagtgat gctttgatgt catcccacac ttcaaataaa agcggaacgt atttcccgct 2157961 gtcctcccat ggcaaatcgc cttgtaattc cgtgcagaaa tcaaaataca cgggattggt 2158021 ctgcaaggtt ttcttcatat ccgaggaact cttctggcca agactgcgca agtattgctc 2158081 ataggaagcc aacacttctt ttgcttgcgt catcgtttca ccagtccttt tttatccctc 2158141 ttctgccctt ctctgcacaa agaaagcagc ggacactccg cacagcgcgg agattgggct 2158201 ttacagtgat atctgccgaa gaaaataagc cggtgatgcg taacggacca atcttctttg 2158261 ggaaccttgc gcatcagcgt cttttcaact tccagaaccg agtccttcca ccggcaaatg 2158321 cccaatcgtt tgctgactct ctccacatgg gtatctacgg ctatggccgg cacgccaaac 2158381 gcaacggata ccactacgtt tgcggtcttt ctcccgaccc ctggcagttt gacaagctca 2158441 tcgcggtctc tcggcacttc tccgccgtaa tcttcaataa tcattttact cagcttttga 2158501 atatttttcg ctttattacg atataaaccg attgatttaa tatcctgctg aagctcttcc 2158561 agcggaacag ccaaatagtc ttccggccgt ttatattttt ggaataatgt tttggtcact 2158621 ctgtttacaa gtgcatctgt acattgcgca gataaagcaa cagccaccac taattcaaaa 2158681 ggattggaat gaaccagttc acactccgca tgaggaaaca tgtcacctat cttgtctaaa 2158741 cagaattcaa tttgttttag atttaacacg attgtcacct tttcacttta ttgttcaagc 2158801 caattgtaaa aaggaacctg ccttttatac tctttttgcg gttcattctg ctttgcttgt 2158861 acacgccgga atttttggct gtgtattttt gcctgctcca cagttttaag cccatttttc 2158921 ttccattcaa acaaaatccg gtcaatgtag cggaaactga gttttcctga tagtacagcc 2158981 tcttttaacg cgtgtttgat cagttgtgcg tcatgctgat cctggtcctg ccagatcgcc 2159041 agcgtttcac actccaaagg cgataacggt cttgcgaact cttcctcaaa aatggtataa 2159101 aggctttttt gttccccttc tgcttttctt tcctgtgttt gattctgtgc aagctgaata 2159161 tactcgtaca gcttgcccca taaaggctga agagaatatt tctcaaattt gatgccgttt 2159221 tgatcctcgc attcttcaat aaacagaaag cctttttgaa taaacatccg caatctgttt 2159281 gtacattctt caacagaaat tgacatacct tcctgcagct gattcggtgt aggaaaatat 2159341 gatccttttt ctaaatgcat tttaattttt aacagcagaa taagttctgt ttcattaagc 2159401 ccaagctgtt tataatgcgt gagcagaaga ttggggatgg ttgatgttcc ctgctcctgc 2159461 atatcaataa attgctgttt tttcatcgtc acacctctta ctgtaaagga ttgtgattgc 2159521 ccctttactg taaaaagtct cccttgcagg agactctttt ttgtttcatt tgaatgtatt 2159581 acggatacag acggtttaac agtcttggga acggaatcgt ttcacgaacg tgaggcgctc 2159641 cgctgatcca agctactgtc cgctctaatc caaggccgaa gccggaatga ggaactgatc 2159701 catattttct aagttcagca taccatttat aagcgtcaga atccagtcca tgttctttaa 2159761 gacgcgattc caaaagttcc atatcgtgaa tccgttcaga cccgccgatg atttctccat 2159821 agccttccgg cgcaatcaag tcagcgcaaa gcacaacgtc ctcacggtca gaagccggct 2159881 gcatatagaa cggttttaag gacgtcggat agcgagtgat gaataccggt ttgtcataat 2159941 gttcagcaat cgctgtttca tgaggcgctc cgaaatcatc tccccactcg atatcgtcaa 2160001 agcctttttc tttcagaaat tcaatcgctt catcatacgt aattcttggg aacggggctt 2160061 tgatttgctc aagttttgac gtgtctcttc ccaatgtgtt tagttcaatt ttgcaatttt 2160121 taagaactga ttgcacgatg aaagaaacgt aattttcctg tacttgaagg ttttcttcaa 2160181 attctacaaa cgccatttcc ggttcgatca tccagaattc gattaagtga cgctttgttt 2160241 tagacttttc cgctctgaat gtcggtccga aagagaatac ttttcctaaa gccattgccg 2160301 cagcttccat gtagagctgt ccgctttgag acagatatgc atcttcatca aagtactttg 2160361 tcgcaaagag ttctgttgtt ccttcaggtg cgcttccagt caaaatcggc ggatccactt 2160421 ttacgaagcc ttcgttatta aagaattcgt aagtcgcgcg aatgatttca ttacggattt 2160481 tcatgatcgc atgctggcgc tttgaacgca gccataaatg tctgtgatcc atcaaaaatt 2160541 ccgttccgtg ttcttttggt gtaattggat aatcggtcgc ttcgtgaatg acttcaatat 2160601 ctgtcacagc aagttcatat ccaagcggag aacgctcgtc ctctttgaca atccctttta 2160661 tatagagcga cgtttcctgc gtcactgatt tagctgtttg gaaaatgctt tcttccactt 2160721 ccgcttttac tacgacaccc tgaataaaac cggtaccgtc ccgaagctgt aaaaacgcaa 2160781 ttttcccgct tgaacgctta ttagcgaccc aagctccgat cgttacttcc tcacctacgt 2160841 gcttgtacac ttggttgatt gttgttttca acatatttcc ctccaaaaca agaaagacat 2160901 tcggaagctc attgccccgc gaactctttt atcatcactt tattataccc gctcttaact 2160961 aaccgggtca atgcagataa aaagcggctt ttctgtcagc cgctttttga tctgttagct 2161021 atgtttttct acaaaacgct tgattctttc aatggcttct tcaagaagat ctaacgatgt 2161081 tgcataagaa agacggacat tctcaggaga gccaaatccg gatcctggaa caatcgcaac 2161141 tttttcctcc tcgagaagcg ctttaacaaa ttcatctaca tctttgaaac cgcaagattg 2161201 agctgcctct tttgcatttg ggaacaagta aaaagcacct tccggcttca cgcagctgaa 2161261 ccctgggatt tctatgagct ttgcatagat cgtatttaat ctatgttcaa atgcttctct 2161321 catttcttcc aatggctcag aaggcccgtt ataagcagca atcgctccgt attgtgcgat 2161381 tgatgtcggg tttgacgtgc tgtggcttgc aaggttcgtc atcgctttaa taatgtcttc 2161441 agagcctgcc gcataaccga ttctccagcc tgtcatgctg tgggacttcg atacgccgtt 2161501 tataatgacc gtttgctctt tcagtctgtc tgacagctgt gcaatggaaa catgtttctt 2161561 tccgccgtat gtaagttttt cataaatttc atctgacaca atcaagatat catgttcaag 2161621 gcacacttca ccgagcgcag atagttcttc ttccgtatac atgacaccag tcgggttgct 2161681 tggagagtta ataacgattg cttttgtttt ttccgtaatt gcatttttca gctgctcagg 2161741 cgaaattttg aagtgatttt cctcaagccc ttctacataa acaggctttc cgccagcgag 2161801 tttcacctgc tccgggtagc ttacccagta aggcgttgga ataataactt catcttcttc 2161861 atccaaaatc acttggaaaa gggtatacag agcatgtttg gcaccagtgc agacaataat 2161921 ttgagacggt ttgtattcaa tattctggtc gcgtttaaat ttctctgcaa tgctgttttt 2161981 cagttcagcc aaaccaccgg aaggcgtgta tttcgtatgg ccctcgttca tcgaacgcac 2162041 agcggcatca ataatatgct gcggtgtatt gaagtcaggc tcgcctgctc ctaagccgat 2162101 gacatcatgg cctgcggctt tcagttcttt cgctttcgct gtgattgcca gtgtggttga 2162161 tggtgttaat gcggatactc tttttgccag tttcaacttg aactccccct aattcgtctt 2162221 aaggcgtgat atttttgaga atctttccag ttgtaaagtc cacataactt aaactgtatt 2162281 gcccttcttt gtctaagtac gtcacttccc aaagcaggac gtttccttct cttgccagat 2162341 gaacctcttt ttgctttgaa accagccctt catcctttat gattttcgcc gctttgtctt 2162401 cagagattcc ctctttcgct tcttttgaga gaatttttgc ttttttatca gcaggaaccc 2162461 agacatataa tgcagtgcct tttttatccg ttccctttac aacataatat ttttcttttc 2162521 cgacaaatgt ttcgacttga tcaacatggg cgagatcggt ttctttttta gcttcagcag 2162581 ctgctgcttc gtgcccctct tccttttgtg ccatggctga tttataaatg cttgccgaga 2162641 caagaagtac tgctaaaaaa ataataccaa aaatgacggt aaatattaat gctttttttc 2162701 tcatcttctc acctacgtac gataaatggt aaaaacggct tggtttttgt tttcttcatc 2162761 cagcgcaagg ccgaacatca gattgtctct tttcagtgta cgattcaatg tgtccacaat 2162821 tttatacaga tcatcagaat gctctacatt aattgttgaa agaatttcga ttttactttc 2162881 cattttttca tcctccagtt tgaacaaata ttgttagtca tactccattt caggacacgc 2162941 catactagta tcacagagcg ggaaatccgc ttttaaataa aacaccatcc tactcccaca 2163001 ccgcaaaagc cgctttatgc ggcttttatt ctttttcccc tgcaacataa gcttcaagct 2163061 cgctgtcagt catttcggat actgaggttg tcggcaaggc atcaagaaac agccggccgt 2163121 aaccagcggt tttaatccgt ctgtccaata taataatcgt tcccttgtct cccgcagaac 2163181 gcagcaagcg tccgattcct tgcctgaagg tcagcacagc ttccggtaat gacactgttt 2163241 gaaacggatt ctttcctttt ttgcgggcaa gctcacattt tgcagcatga agcgggtgat 2163301 caggggaccg gaatgggagc ctcacgatca ttactgtcgt cagctcatca ccagggaaat 2163361 caacgccttc ccaaaaatga tttgttccga gcaggatcgc ctgattggat gttttaaaag 2163421 tcttcatcag tttgccggga cttccgcctg taatcccttg tgccaagagc tgaatgccgg 2163481 aagcactcat gttatgctta agctcctggt gaaccttttt cagcatatca tgggatgtaa 2163541 acagcacaag gattttaggc tgtttttcct ttgccatcag ttcgatataa cgggctgtat 2163601 cctgtataaa ttcaggttgc cctgtatcct gaattgattt catttctttt ggaatcatca 2163661 cctgcatacg ctcatcgtaa gaaaagggtg actcaattct cattgtccgc gggaaaaagt 2163721 cactcagtcc cagtcgttca atcataaatt gaaaagaacc ttcgactgta agagttgcag 2163781 atgtcagcac cacactattt ttgcgcgcga aaaactgatc agccagaagt tcaccaggtt 2163841 caagaggctg tgcgtaaatg gccactgcat ttttcgcacc ctttgcatct atttcaatcc 2163901 aaaccgcttc atcgtcatca gagccaaaga agagcttctg caacgtctga cagtaatgct 2163961 gcaagccttt catgcttctt tggtattcat cggctaaaaa gacggttttg ctcttcatgc 2164021 ccttcaaatg tttttccata agggatgact gcgcctcaaa aagctgctgc aaatgtgtca 2164081 gcatggaaca aagcctctcc gcaccatctg ttaagatcga ccagctttta tcctggcttt 2164141 ctttgttcac cttaaacact agacggttta agtcttcttt aggttttctt cgtttgacaa 2164201 aagaatgtac agagctaaag aaagcatcac tttctgcttg aacgtgctga agccactctt 2164261 ccaattcgaa aaatgaatca accggcaggc tgtttcgctg gaatagctgt ctcatctttt 2164321 ttagaagtcc ctgctccttc agagtgccga ttctgctcaa tttcgtatgc aattctatgt 2164381 acgtggctct tttccctaaa tgttcgcttg ccgcacgttc aaaatggtgt gcttcatcaa 2164441 taataaatgt gccgctttcg ggaagccttt ttttatggct gccttcatcg gtcagcaaaa 2164501 gagaatgatt ggtgatcacc aaatcggaac gcatagcaat ctgtttggcc cgctcgtaaa 2164561 aaccgatcac atgctcactg cgacttcttt tataggagtc atcgtcataa gccaatctgt 2164621 cccacagcaa ttttccgcct gaaggcaaat tcagttccgc tacatctcct gtatttgtct 2164681 ctgtcagcca aacaagaagc tgtgcctttg tcagtacggc atcataatta tcatcttctt 2164741 catgaagcac ctgctcaaat ttatacaggc ataaataatg cgattgccct tttaaaatcg 2164801 ccgctgttac cggaaatgga aacagatctt ggacaatcgg caaatccttt gtgagaatct 2164861 gctgctgtaa aagcgtcgaa tacgtgctga ttatgaccgg cttttttgat ttcttggcaa 2164921 aaagcgcagc cggaataaga tagccaatcg tttttccgat gcctggagga gcttcaatca 2164981 gcgcatgctc acgattggca aacgcatcag ccacctctct catcatcatc atttggccgt 2165041 ctcttttttc atacccaggc attaactctg acagcgcttt ttcatttccc gcttcccagc 2165101 tttcgatctc aaatgagaag ttctcgtcct catttatacg aacatcgata gcttcaggtt 2165161 ctctgacaga aaacgaagaa aagcgcgtat agcccggtat ctcggtatgt ctgttttcat 2165221 taatgaacat atccaacaaa tgcgtcagat cactgatgaa atgctgcgaa agccttctta 2165281 actgctttaa tgtcggataa ggaagctgcc gcagcttttc aaggatttcc aaaaaaataa 2165341 gccctgtcac ttcagcatcg ctgtcagccc ggtgcggctg atcatgccgc agctgaagct 2165401 cctcgcttaa ttccgtcagc ttataccctt caaatcccgg aaaaacaatg cgtgagagct 2165461 cgacagtatc aagcacttca caatctggga gctgaaagcc cgccttatgt agctcatact 2165521 tgacaaatcc aaggtcaaaa tggatattgt gggcgacaaa ataagcgccg tcaagcaatt 2165581 ggaatacttc ttcagcaact gcttcaaatg gctgttcatt ctcgaccatt tgattagaga 2165641 ttccagtaag ctgctcaata aaagcaggga ttgatttatt tggattaatg tattttgaaa 2165701 accgctcagt aatttgtcca ttttcgatta caaccgctgc gatttgtatg attttatcgc 2165761 ctttcttcgg cgaattccct gttgtctcta catctataac aacgaaccgt tgcttattca 2165821 ttaaaatgga cacctcaatt cttgcatacg acaaaagtgt aacacgtttt gtacggaaat 2165881 ggagcggcaa aaccgtttta ctctcaaaat cttaaaagaa aacccccgat aaagggggct 2165941 tttcttctac aaaattgtac gggctggttc gttccccagc atttgttcaa ttttgttttg 2166001 atcattcaga acagccactt tcggctcatg gcttgccgct tcttgatcag acatcatttt 2166061 gtaggaaata ataatgacct tatctccttc ctgcacaagg cgtgcggctg caccgtttaa 2166121 gcatatgacg ccgcttcccc gtttaccagg aataatatac gtttcaagac gtgctccatt 2166181 attattattc acaatttgta ctttttcatt aggaagcatt cccacagcat caatgagatc 2166241 ttcatcaatt gtaatgcttc ccacatagtt caggtttgct tccgtaacag ttgccctgtg 2166301 aagtttgccg ctcatcattg ttcgatacat attatattct ctccatttct cgaatatcaa 2166361 taatgatatt atctattaaa cgcgcttttg aaaaagcaac tgcaacagcg agaatcatct 2166421 ttccagcaat ttcattcaca ggctcgagtt ccggatagga ataaagctct acatagtcta 2166481 tggttccgct agtcgtttca atgatatctt ttgcagcttt tatcaccgct tcaggatctc 2166541 tttcaccggc ttggacaagt tccgcacttg tttgaagggc ccgatacagc ttaggcgctt 2166601 cttttctttc ctcagctgtt aagtatacat tgcgagagct tttggctaag ccgtcttcct 2166661 ctctgaccgt atcgacagga accaattcaa tatccatgaa gaagtcgctg attaacccat 2166721 caacaacagc tacctgctgc gcatctttta aaccgaaata ggcacgagtc ggcttgacta 2166781 gattgaaaag cttcgtcagt acgatcgcga ccccgtcaaa atgtccttct cttgagcgcc 2166841 cgcataacac gtctgtgcgt ctttctacat gaatcgtgac attcttttca ccgggataca 2166901 tatcatgagc atctggcgta aaaagaatat cgactccggc gttttctgca agagctgcat 2166961 cccgctcaat atcgcgcgga tatgcttcaa aatcttcatt agggccgaat tgtgcaggat 2167021 tcacaaaaat actcataata acggcgtcgt tttcttgtct tgctttgtct gctaaggtta 2167081 aatgcccctc atgcagaaac cccatcgtcg gaacaaatcc gattgacttg ccctctgaat 2167141 ggtattgttt tatggcttct ttcagctgtg aaatatcagt aatctgtctc atcttatttt 2167201 cccccgtaca agccgtcaag cactgtctgg ttcatttgaa aggaatgctt ttgttcaggg 2167261 aaagcacgat gtcttacatc ctgaacatat ccgctgattg ctgtttcgat ggtttcatca 2167321 atgcgcgtat attgctttac aaatttaggt gttctctcaa caccgtggcc gataatatca 2167381 tgataaacga gaacttgtcc gtccgctttc acaccagccc cgattccaat gaccggtatg 2167441 cttagcgtct cggcaatttt ggctgtgagt tctgccggca cacattccag cacaagcatc 2167501 atagctcctg cttcttcgca ttttatactg tcttctatta attttttggc gctttgttcg 2167561 tctttgccct gtactttata gccgcccagt acgccgactg actgcggtgt caaacctaag 2167621 tgactgacta ctggaatgcc tccaagcgtc aatgcgcgaa tggattcaaa cacgccttct 2167681 ccgccctcaa gcttcagtgc gtcagctccg ctttcctgaa cgatagccgc tgcatttttc 2167741 agcgtatctt ccttagacag gtgataagac ataaacggca tatctgtcac aataaaggta 2167801 ttcggcgcac cccttttaac ggcttttgta tgatggatca tgtccgcaac tgtcacaccg 2167861 acagttgaat caaggccgag gacgaccatt ccaagtgaat caccgactaa aatcatgtca 2167921 actcccgctt gttcagcaag tttagctgcc ggataatcat aagcggtcag catgacaatc 2167981 ggttcttcag actccttcat ttttagaaaa tccagttttg ttttcatgtt ttctcctcct 2168041 catgtttaga ggagatgatc tgccgttttc ttctgcaagc caaaaaacct tccgttacaa 2168101 cgagaaggat tcttcacttt ctaaagttcg gcgagtttca tccctctgtc ccagtccttt 2168161 tttggatcaa ggcagactgc tgcaatgtct atctatttta ataataggtg cagttcgcag 2168221 gcgatactgc ccaatggaag tataccaaaa tcaacgggct tgtaccaaca cattagccca 2168281 attcgatatc ggcagaatag atttttttaa tgccttcgtt cgtttctaaa agcagaacgc 2168341 cttcatcatc tatacctaac gccttaccgt aaaaggttcc gtttaacgtt ctggctctca 2168401 tattagtgcc aataccgagc gcatagcttt cccataaaag cttaatcggc gtaaatccgt 2168461 gcgtcatata atcccggtac cgtttctcaa agcatagtaa aatatgctgg atgacgccgg 2168521 cccgatcaat tttttcccca gcagcttggc tgaggcttgt cgcgatgtcc ttcaattcat 2168581 ctggaaaatc attaggctgc tggttaacgt taatgccgat cccaatgatc actgaacgta 2168641 cgcggtcttc ttcagcctgc atttccgtta ggataccgac tgtttttttt ccgttaatca 2168701 aaatatcatt tggccattta atatccgttt ggatgcctgc tgcctcttct attccctgca 2168761 caacagctac tgcagcaagc agagtcagct gcggtgtttt ttggagcgga atgtcaggcc 2168821 gcaaaatcag gctcatccaa acaccgtttc cttcttgaga atgccatacc ctagacattc 2168881 ggccccttcc ggctgtttgt ttgtcagcca ccacaagggt gccttccggt gcgttattat 2168941 tcgcgagctc atgagccgtt ttttgcgtgc ttgaaagaac gtcatggtaa ataagatgct 2169001 ggcccatcac ttccgttttt aatccaaaac gaatttcgct ttcactgagt tttccgggtt 2169061 ttttgatgag ccgatatcct tttcttctaa cggcttctac ttcataaccc tctttccgaa 2169121 gctcttcaat atgcttccac acagcagttc ttgaacagcc gagagcatca ctgatttttt 2169181 ggccggaaat aaattcattg ccggcctgag aaaataattc aataaggtct tttcttaatg 2169241 ttgaccgcat gtcttcagcc actcctctat gtgtttcttt tgattggaga gcttccctgt 2169301 cacaacagcc tgctcgatcc actgtaattc ttctgacacc cattttccgg ccggccggtt 2169361 tcgaagcgca agcaagtcct tacccgtgat atcaagatcc ttaaggcttt tgatcggcag 2169421 gttttgataa gcgtactgaa tgtccttcag tttcttttca tccagttttt cgttttgccg 2169481 aagctgcgat attttggccg ctgagagcag tgcttttttc ccagctctgt acattgtcat 2169541 tgcgtcaagg ctctggccaa acgtatcggc aatgtgaatg gcttccttga tcacttttcc 2169601 cgggagcttc caggctttca ggaaaagggg cgcgtctttc aaaactatgc caaggttaat 2169661 taaaagagca gcccaaagct cctcacggga tgttaaagag aagaatggaa actcactcgt 2169721 tgaaatcagg ttttctcgtt tatgataaaa accaggaagc tcttcataca atctcgtttg 2169781 aatgagtgtt tgaagcgcct ggcgagaagc tcttccctgc agcaatttct caaactctat 2169841 agtttttcgt tcgactgaaa catgggagag gagtgatttt tctttcgcaa tggcttcttc 2169901 tgtttccggt gaaagcgtaa agccaagctg gctcataaag cgtacggctc tcagcatacg 2169961 aagcgcatcc tcttgaaatc tatcctcagg ctttccaacg gttcgaatca ctttctgatc 2170021 aatatctttc ttgccgccaa aataatcaag caccttcccg tccgctgtca tggccatcgc 2170081 attgatcgtt aaatctctgc gttttagatc ctcttctaat gatgagataa attgcacttc 2170141 tgacggtctt ctgaaatcaa cataatcaga ttcagtccgg aatgtcgtga cttcataggt 2170201 ttcatcctcc cagagcacaa taatggtccc gtgctctttg cctacatcaa cagtccgctg 2170261 aaacagccgt tctacttgat caggtgccgc atctgtcgcg atatcgacat ctccgatcgt 2170321 tcgtttcata tagctgtcac gaactgcgcc cccgacaaaa taagcctgat ggcccgcttc 2170381 gattaagatg cggagcacgg gaagtgcttt gataaaaact ttttccatgt gatcactccg 2170441 gttctgctaa atcggcataa atctgttcat actggctgac aattttttta gaagaaaatt 2170501 cattttcaag catctctatt gccgcctttg taaaacgatt gcttagctgt tcatcttcta 2170561 aaatgctcat cgcgcgggct gttgcggccg taacatcacc gacatccacc aaaaatccgc 2170621 tcacattgtt ttttataacc tcagggatac cgccaatgtt tgttccaata caaggcactc 2170681 cgcaagccat cgcttcaagc aggacaaggc caaagctttc tttttcagat agcagcagct 2170741 tcaaatcgct aatagaataa agatcttcaa cacggtcttg atttccaagc attaagactt 2170801 ggtcttccaa gccatatttt ctgataagct cgcaggctgt cgatttctcc ggaccgtctc 2170861 cgactaaaag cagcttcgct ttcgttttgc cagcgatatt gcggaacaca cggatgacat 2170921 cctgcacgcg tttaactttt ctgaagttgg acacatggat gacgactttt tcatctggta 2170981 aaattccatg tttctcttta attgccgctg tgtttttctt cagatacacg cgctcgtcta 2171041 taaagttata aatcgtttca atttttttct ccggtttaat taaatcgtat gtttcagccg 2171101 caagcgctga ggagacggcc gtcaccctgt ctgatgactc aatagcaaaa cggatcagat 2171161 cttttagaga cggatcataa cctaacaccg tgatatccgt gccatgcaaa gtggtaacaa 2171221 tgccgatatt gcgtttcagc atttgttttg caagataggc gcaaacggca tgcgggagag 2171281 catagtgagc atggataatg tctaaattct cccgttccgc cacctcagcg attttgcttg 2171341 ccaatgtcaa atcatacgga ggatacttaa aaacagcata ttgattaacc tcaacttcat 2171401 gaaaatgaat attgggatga tatgtattca gtctaaacgg aatgcttgat gtgatgaaat 2171461 ggatttcatg tcccttttca gcaagctgct tccccagttc tgtcgcaatg atacctgagc 2171521 ctccaacgct cggatagcat gtgattccta tttttagttt tctcattgtt cgcccccaag 2171581 cacatcatga tcaagcatca gcatccgttt ggaaaagaaa ccttcggcat actccacgcc 2171641 cgcttcttta ccgtaaagct tttctctcgc ttcaacgatt tcaatatacc cattcgtcag 2171701 aggagtagaa acggaatcct ttgacgggat aaactggctt ttgtaggcgt tgaggctttg 2171761 tttctttgcc tctattgtat ccgagatatc aataacaaaa tccggctgat gaaaaccatt 2171821 tatcatataa tagtaaacct tgctgacttt atgcgccgga aggctttttt cgtctttata 2171881 tttatggatt ccggcggaaa agatcgcttc ttccaccagt gcagccgcat tgccgtgatc 2171941 cggatggcga tcctttttat acggcataaa aaccgctttt ggccgacaga ttctgatgac 2172001 agtgacaatt gaccgaattg cctgatcact cattattagg ccgcggtctg gaagcgttag 2172061 ctgaattctt ttatctgcgc ctaatatgcg ggctgcttca gctgcttctt ctttacgcaa 2172121 actgaccgta ccgttagaag agagttccgc ttctgtcaaa tcgcatatca ttactttttt 2172181 ttcctgtttg acaaacttcg ctattgtgcc gcccattccg atctcgacat catcactgtg 2172241 ggcgccaaaa gcaagaacgt cagcattata cattcggctc ttctccccga agaaggtcac 2172301 ggaattcgaa aacaccttca tcaagtgtgc gcacaagaat ttccgcagta cccatatttg 2172361 tggcgagcgg aatggaatac acatcacata aacggattaa tgccgagaca tccggttcat 2172421 gcggctgcgc ggtcagcggg tcgcgcaaaa aaatgacaag atcgagtgca ttggcagcga 2172481 tcagtgcacc gatttgctgg tctcccccta aagggccgga ttgaaaacgt tcaatttgaa 2172541 gacctgtcgc ctcatgaatt ttcaaccctg tggttccggt tgcgtataga tcatgattct 2172601 ttaaaatatc ccgataggca gtcgtaaatt gaaccatatc ctgttttttc ttgtcatgcg 2172661 cgatcaaagc aattttcatt gtttatcccc ccgtctaatc aatgatattt tctaaaccat 2172721 acacaagctg atcaatcttc atgacttgtt cgactgacag tttaacgcct gacatgaaag 2172781 aagcacggtt ataagaatca tggcgtatct gaagcgtttg gccatccatg ccgaacatga 2172841 cctcctgatg cgcgatcagt cccggaagac ggacgctgtg caagcgaata ccgttttgct 2172901 ccgctcctct tgctcctggg agaatttctt tttcatccgg atgtccttgc tgcttttctt 2172961 tacggacttc tgaaatcatt tccgctgttt taagcgcagt tccgcttggt gcgtcaagct 2173021 tctggtcatg atgaagctca ataatctcaa catcctcaaa atagttggca gccatttttg 2173081 aaaatttcat catcagtatc gcaccgagcg caaaatttgg cgcgatgatg gctccgatcc 2173141 ctttttcttc tgttaaagat gtgagctctt ttaaatcagc ttctgagaaa ccggttgttc 2173201 cgacaactgg acggactccg tgctctaatg caatttttgt atgtactttt ccgatttcgg 2173261 gcgttgttaa atcaatcaag acatccggtt gtgtttctgt aaaacaggca tggatatctg 2173321 tgtaaatgaa agcatctgac tcaacaggca tcacatcaga taatttttgc tgatcgtatg 2173381 tatggtctat ggcccctaca aggtcaaaat gtggtgttcg ttctgccaat ttaacagctt 2173441 cctgccccat tcttccacgc ggtcccgcaa tgactaattt aattgtttcg tttgacatct 2173501 tgatctcctc tactttcctt cttcttttct ggtccagcga tctttatctc ttgtattaaa 2173561 tttatgcatg actcggtcgt gagcttcctc taaagagata tcaagagagt tggctaaaca 2173621 aaccaataca aatagcacat cgcctatttc ctcttccatg cttttatcat cttcagtcgc 2173681 tttttttggt ttttctccat aacggtgatt cacttctctg gcaagctcgc ccagttcttc 2173741 agtcagcctc gccatcatgg ccagcgggct aaaatatcct tctttaaatt ggcctatgta 2173801 acggtctact tcagcctgta tgtctttcat tgttttatca ctcactgaac gaaacctcct 2173861 atcatcctct tacatgttag ctaattcaga tacgtttgac aaatgtttaa gcacgtttgc 2173921 tgttttcttt ttcatccact ataatataaa cgctatctaa tggaaggaaa aggggttttg 2173981 tgtgatgctt ggagaaatta gattaaaaaa catatttttt attttaatcg gagcggcaat 2174041 tttttcattt ggcttggttc atttcaatat gcagaacaat ctggctgagg gcggttttac 2174101 aggtattaca cttttgcttt atgccctttt ccacatcagc ccctctatat cgaacctggt 2174161 gttgaacatt ccgatttttt ttattggctg gcgtttgctc ggcaggacaa tgtttgttta 2174221 tacccttgtc ggcactgtag ccttgtcttt gttcctcagc atctttcagc gatatgaaat 2174281 ccatatgccc cttcagcacg acttagcgct cgccgcttta tttgccggcg tattcatcgg 2174341 agccggactg ggtattattt ttaagttcgg cggtacgaca ggcggtgttg atatcatcgc 2174401 acgtttagtg aataagtatt ttgggattcc gatgggcaga acgatgtttg ctttcgatgc 2174461 ctgcgtcatc attttgtctt tgcttactta tctctcctat aaagaagcga tgtatacgct 2174521 ggtagctgta tttgtagcgg caagattaat cgattttatt caggaaggcg gatacgctgc 2174581 taaaggcgct acgatcatct cttcgaaaaa cgacctgatt cagaaaaaga ttcttgaaga 2174641 aatggaacgg ggcgtcacca ttttgaaagg acaaggttcc tacacaaaag aggatataga 2174701 tgtactttat tgtgtggtgc cgaaaaatga attggtgatg ctgaaaagcg tgattaactc 2174761 cattgatccc catgcctttg tagcggtaag cgatgttcac gatgtgctcg gagaaggatt 2174821 tacgcttgat gaaaataaaa atccgcttcc gcgctgacat gtaatagaaa aaaggcggct 2174881 gaccgccgcc cctcatcctt atttagggta gtcccttttt ttcagcttgt ttttttccgc 2174941 cttgtacttt ctgtaaccga cataggtaag agcagtaatg atgatactgc cggttgtaat 2175001 gatcacccag agtaaagacg gatcggcatc atcctcctcc accctgtcaa acacattttt 2175061 caggtcatgc tgaagaaggg aaagccgttc aagcttcgtg ctctctgtca tttgctgaaa 2175121 ttcctcttgc tcaataacat ctatatgttt tccgactgtt tcaagctgat cctctgatac 2175181 atcgattgta agactggggt aaatcaagtc atataaactg ataaattcat tccatttttc 2175241 atgaaagctt gtgcttccat tcttttggac atctcgcttc agttcagtaa aagcttccat 2175301 aatcggtttt tccagtgagc cccaaagcgg gtcagaccga ttgtcaaccg catccatcag 2175361 cattctgaac tgcgcggctg ctctgagttt ttgtgtgtct gatgtatcag cttgctttaa 2175421 actccgaacc atatcattat agcccaatgt gatttgacga atttgggctc ccgttagcat 2175481 ggggtcttgc tgttttttct cagcggattt taatgttttt tcaaaatact ccaagacttg 2175541 aagcgcctct tcatatttcg cctgtcgggt catttgaaag actgtatcgg ataaatcatt 2175601 caattcctcg aggcttcccc gctctgcagc cttggcattt ccattataaa aaataagtgc 2175661 aatcaacaaa cagatcgtca gctttcgttt catgcaggtc cctcccactc tctctcctta 2175721 cagaatatga agaaagggac aaggatagac caacattgtc tttacatcag ctcaagcttc 2175781 gtttgctttt ttgagaccac aagaaagtaa gcaagcgcga ttgaaaagat acttagccaa 2175841 aatgttccgt atcctatttc agtcatataa tcagaaagca tagagtattg cggcatcata 2175901 tcaaacaagt agtcaatgac atcgttatgc agtgtccaga ctgcagcaat tgcaagatgc 2175961 caaaatgaaa aacgaaaata cggactgtat aatacgcctt gaactgccat tgcaaaatgc 2176021 gaagcaatta gcatgtagcc ctcccacggc aagtcaccag ttactgcaag cacaagaaaa 2176081 ttcatagcca ccgcccatag gccatacttt acgagggtaa ctagcgcaag cgcctctaaa 2176141 agcggagcat tccgtttcat gagaaaggca agcagcacaa acagaaagaa aaacgttgct 2176201 gtcggactgt ccggaacaaa aatcaggaaa cgggccggtg tctccaaaag ctgcggcaag 2176261 taccaatagt agccgtaaac cgttcccaga aaattaatgg ctaagacaag aataagcatc 2176321 ggccgctgcc ctaatacata ttgaaaccat ttcacatcga atcaactctc agtctgtaaa 2176381 aataatatgt ccatataaaa aagctgacgc cgggtcagct tttgataata aaagtatatc 2176441 cttccatttg acaattcaca atacgttatt ttgcggttgt ttcagaaata aattttgcaa 2176501 gttcttcgag ctgcttatca tttcctttga acacacccgc cggcattttg cctttccctt 2176561 ctacagcgat ttttttgatt tcatccggtt tcagcccgct gtcaaccaat gaaggcccgg 2176621 ccgctcctcc ctgaaggtta tccccatggc aagaaataca gccctgttcc ttaaaaacct 2176681 tatatccttc tgcattggtg tcaatgtcgg cttcttttgt aattttcccc tgttcttctg 2176741 ccttggccca gtcatgagta gcaactgact gccacgtcaa aaatacagca gcggaaatgg 2176801 ccagaagcat cataccgaca gcgaccggac gcttccacgg ccttctttct gtccctctgt 2176861 ctaggaatgg agccaaaagc agggccccaa aagcgagacc tggcataatc atggcgccga 2176921 ccactgtaaa gcttccggcg gcgtattcat acttcaacag ctggtataag aaaagaaaat 2176981 accaatccgg cagcggaata taaccagtat cagtcgggtc cgccatccgc tctaaaggcg 2177041 gctgatgcac aatcgtcaaa acgagaaaac cgatgagaaa gacagctcca accatccatt 2177101 cctttaacaa gaaatttggc cagaaagcct ctgttttacc cggatactcc gaataatcct 2177161 tcggtatatt cggctttttt tcagccggta tccttgagtc gcctacaaat ttcatccctt 2177221 tgccccggtg catgtcatcc cctccctttt attcgcagat caagagttta aagcggtcct 2177281 gaaatcccct gcttccggat cataataaaa tgtgcagcca tcagcccgaa caatgcggca 2177341 ggaagaaaaa atacatggat cgcaaaaaac ctagtcagcg tttgggcgcc tacaatatcc 2177401 ggatgccctg caaggagcgt tttaacttgc gttccgatca aaggcgtggc ttcggcgatc 2177461 tgcagtccga cttttgttgc aaacagagcc ttcatatccc aaggaagcaa gtagcctgta 2177521 aagccaagac cgagcataac aaaaaagatc agcacaccga caatccagtt cagctcgcgc 2177581 ggttttttat acgcgccttg gaaaaagacc ctcagcgtat gtaaaaacat catcacaatg 2177641 accaggctcg caccccagtg gtgcatcccc ctgacaatct ggccgaatgc cacttcattt 2177701 tgcaaataat ataccgattc ccaggcattt ttgatatcag gcacataata catcgttaaa 2177761 aacattccag ataatacttg gataacggtt acaaaaaacg tcagtccccc aaagcaatac 2177821 acaaacgcag agaaatgatg ggcgggattc acatgttccg gtacttcgtg atcggcaata 2177881 tccctccaca tcggtgtaat atcaagccgc tcgtctaccc agtcataaat tttgttcagc 2177941 atgtcaccct tcccccttag gctttgcttt tccaagatac aggaagccgt cttttacttc 2178001 ttgctcataa tgatcaagag gcgcaagcgg cggcgtgcca gggacattgg tgccgtcctt 2178061 ttcatagagt ccgtaatggc atggacaaaa gaatttattc gggtttttag gatcactatt 2178121 ccagttcacc gtacacccta aatgcttaca aattggcgaa agtgctacaa tttcatcccc 2178181 gtttttgaag acccaggctg atcttgactc ttctgactca taccaggcat cgacttgatt 2178241 aattttaaaa tcaaagcgct gcggctcttt tgtcaactca tcaacgctga caacctgaac 2178301 catatcctgc ttccctgtcg attttaatac cgggtcgagt gcgaagcgaa ccataggcat 2178361 gagcatacta gccgccataa aacctcctac gcctgtgagc gtataattca aaaattgacg 2178421 tctggatata tcatgttttc cgcccatctc ttctcccccc tctaagtcac ccctgcaaac 2178481 tgactaaaat agaaaatatt gcaataactc tagacaccct cataatatat gaatctctca 2178541 gcaaggtcaa tatagccaaa atattgttta taaggaaatg taagtgtttt tataaagtgc 2178601 tccataactg taacaaaacg ttcaaaattt cagcagtgcg ttcatccaat atttttcttt 2178661 ttaaagagtc atttaaatgc tctaatggaa cagacgatgt aacaatcatt ttgcctaacg 2178721 catcctcagc tctccaactt tcgtcagatg tgagcaggac aacatgcgga aattccgtta 2178781 tcagctcttc ccgcaaatcc ttaagccctt gaacggttat ttcatttcta tcaacatatg 2178841 tataaggcgg aagtaaatat acccgtccct ttaactgcct ttcaagttct tctgagagaa 2178901 gctgcgtaaa ctcgcctttc tccgccgcca ttttaaaatg gttattaacc cttatgttaa 2178961 ttaatggtat gacagcggta tcaatgtaat ccttagcttg taaatagtcc ttggcatcag 2179021 tgattctcca cctcatcgtt ctcccccttt acggcaacaa gccttgcaat tcactgcaag 2179081 gctggtcata ttatgtgagc tgatttaatt ggcgcgataa ttgttcaaat gcctctttat 2179141 catgacgatc taacgcgtcg tcaatgtctt ttaataattt ttctctttgg aatgtggaaa 2179201 tagcgtgctc taaaatctgt tccgccaatc cctgatcttt tttattctca aaaaggtttt 2179261 tcggaatatg cgggttggac tccagcaccg ccgcatattc aggtgagctg taagccgaac 2179321 ggaaattaag ctggataaac aaatcctgct gtttatttaa tctaatatca tgaaaagatt 2179381 tttccgcgtc ggtagtcatg acattctctt tatagaaccg gaacggaact tcttcaacac 2179441 aatgtgttga cattataatg cctctcgggc aaaattcagc ctgctccaca aaatgaacct 2179501 tctccatgag agaatcatgg ctcattaagt agttcaagat ccaaacgcac tctcggcgct 2179561 ttaactgata atggtttaaa aaccaacgga taaaatcttt tttctcattg acagaaacag 2179621 gggtctgcat gtaattccct cctctatcgt tcgtataatc tatatactta tatgttccac 2179681 atgaatggtt aatattcctg cttatctaga aaattcatcc tcgattcgca aaatcgtttc 2179741 ttcaagctct tcattggctc cgtccatttc aagaaccttt ttcaaaagcg gcagcgcttc 2179801 tttttgaaga ccttcttcta ataggaagct tgcgtattca tataagaaat ctctatcctc 2179861 ccggtaatga agataggcag cctcaaagga ttgttttgct tcctcgtatt gctctaattc 2179921 agtatatgcg cttgcaagat accaattgta tttaggatct tcttcaccgt agcttcgaac 2179981 ctcttgaata agatcaatga tctgatcata atcctcttct ttgtgataca cggcaagaag 2180041 tgtatgaagc gcctcgacaa agcccggatc aagcgcaagc gcctcctgaa gcagcttctt 2180101 cccctcttct gacttcccga ttttcaaggc cattttggcg gcataaagga aaagttcttt 2180161 gttatattca tcatatctga tcccctcttt tgccgttttt aatgcctctt catacattcc 2180221 ttcagcttca tagcttttcg agagcggcat ataaagtgaa gtataagatg gatcaagctc 2180281 ctttaaatca gacagctgct taatagctgt tttcacaagc cccgcctgta aggctgtaaa 2180341 accatagccg aaaatcgtat taggatcagg attctcatcg acagctttct cataccatgg 2180401 aatggcatcc tcaaattcac ctgaggcact taacgattct gccagtcttt gatggacatt 2180461 aacgcccccg atctcactct gctcctcagc cgttgtttta aaatattgaa ccgcttttgc 2180521 ataggctccc tgagcaaagt aaagttctcc cagtgcaaaa tcaataacag gttcattgtc 2180581 cagaatggac tttgcctgga aaagcttttg ttcactgact tcgaataacc cctgcatctg 2180641 ataaagatcc gccataagca gcaaactttc cggatatgat ggatctgttt ccggaatagt 2180701 ctccagcaca gcgagggctt tttcttcttc gtcaatatct attaaaagtt cagcgtagaa 2180761 attcgtcagt tctgtttcat ttggatataa atcatgtaga tcactaatca gtgaaatggc 2180821 tttttctaca tcgccccact cgtaataaag ctgggctgca atggctttat cttcatcatg 2180881 cagctgtttt tcagccttcg agagcgtgtt gaggcctttt tctgtttcac ctgcttcaac 2180941 taattttatg gcttcttgaa tcaatgtatt caaatcggac cggtcctttc ttttcctata 2181001 caacatcaac catacaaaaa aagctttatt tgttcgggtt aatcttatca taattcagac 2181061 gaatgccccc ggcaaataag atgcttctgt acggaaggga attattgagt cttattagtt 2181121 taccaaaaga tcttgagata gaaaatgaaa aaaggaagat cgccctctgt acagtaaagc 2181181 agctctttga cctgccggct tgtaagtaaa gcacatcccc ccttttcgtt tttctatccg 2181241 ttctataaga caagctatgt tttttcgcct cgaattatga tctgcataaa aaatcctgaa 2181301 gtaaaacttc aggatttttt cgaaagctta tttaaatgct cgaagaaggt tggataagaa 2181361 acgtgaatgg catccgtgtg ctcgatttca atcggctcct ccgttataca ggaagcaata 2181421 ccaagcatca ttccgattcg atgatctccg tggctggaca ctgcagcgcc gcctttcaac 2181481 gtttgtttgc cataaacctt cattccatct gctgtcggtt caatttcagc acccagcttg 2181541 cgaagctcag aaacaacagt atcaatacgg tttgtttctt tcacttttag ctctgccgcg 2181601 tccttaataa cggtggttcc ttccgcctga gtcgcaagaa gcgcgatgat agggatctca 2181661 tcaattaaac gcggaatgat atctcctccg atttcaactg cctttagaga tgacgtttct 2181721 ataatcaaat ctccataagg ctctgcaccg ctatcagcag atggtttgat ttcaagtttt 2181781 gcccccatgt tttgaaggac atcaataata cctgtccgag tcggatttaa acctacgttt 2181841 ttcaatacaa ttctgctgtt tggaaccatc gcgccagcag caaggaaaaa cgcggctgaa 2181901 gaaatgtctc caggaacaaa aatatcagca gctgtcagtt tctggccacc agcaatggaa 2181961 acactcgttt gatcttcaga aagcttaacg ccaaaagcag aaagcatccg ctcagtgtgg 2182021 tcccgagatt tatggggctc tgttacagtt gttgtgccct cagcctgtaa tccggccagc 2182081 aaaacagcag atttaatttg cgcgcttgca acaggtgata cataatcaat tccttttaat 2182141 gaagcgccgc tcactgacag cggtgtaaac tctccgccgg ctctgccgtc gattttagcc 2182201 cccatttttt tcaaaggctc agtcacacgc ttcattgggc gtttcgcaat gctctcatct 2182261 ccggctaccg cgctgtaaaa aggacggccc gccaatattc cgagcatcag gcgaatcgtt 2182321 gtacctgaat ttccgacatc taaaaggctt tctggctctt tcagggcatc gattcctttt 2182381 ccgtgaatca cgacatcgct gctgctttgc tcaatgtgaa cacccatttt tctaaagcaa 2182441 tcgatcgtgc tcagacaatc tgctcccggc agaaagtttt taactgttgt tgtgcctgcc 2182501 gctagcgcgc caaacataac agagcggtga gaaatggatt tatcaccggg aatatgtatt 2182561 tctccatgta aggtctgcac cttatctcgt ttcatttttt ccacctcaat cagcataaaa 2182621 agtttcatat tccgcccggg cttcaatgca ttgttctgcc cttttgcggt cgtcatcaga 2182681 ctgaaaactg atccttaaaa tcccgttaat atcctctcgt gtttcgataa tgcggatatt 2182741 cgtgatactg atgcgctccg cagctaagat cgctgttatc tcggatatta cacccggatg 2182801 atcgggtaca tccacatata aatcataaaa tgcaggtatc gctcccttct gccgaagcgg 2182861 cagcccgtcg cgataatcct tggctgtttt aaaataacga aatagatttt ccgcatcttc 2182921 ttgttctaca tatgtacgga tcttgtcaat ttcacgaatc cactcatcaa aacggtctaa 2182981 gattttatct ttattatgta ataaaatatc ccgccacatt gccgggctgc ttgatgcaat 2183041 ccttgtaata tctctgaacc cgccggcagc aaaacgctta acaagcggat acaggttttc 2183101 cgaatgatgg gtttggtgaa caaggctagc tgctacaata tgcggaaaat gactgattac 2183161 gcttgtaacg ccatcatgct cctctggcga catttccaca aaatgggcat tcgtcccctt 2183221 cagcaggttt tttaactgtt ccacagcttg tttgtccgtt ttctggcctg gcgttaaaat 2183281 ataaaatgca ttttcaaaca ggaactcctt cgcagcggcc actcctgatt tatgtgaacc 2183341 cgccatcgga tgccctccga caaattgata gcggctaggc agcacttgat cagcgtaatc 2183401 aaccactttt tgctttgtgc ttcctacatc cgtaatcaaa agctcatgtt caattcctga 2183461 atgagccagc tcttcaagca taaccagtgt ttgttcaaca ggtgtcgcaa tgattactgt 2183521 agctgcctct ttcacaccgc taataaacga atcagcacga tcgtctatca cgcctaattt 2183581 taatgccgct accgcctgtt catcagagat gtcgattccg ataatccgtt tgccgggatg 2183641 attttttttg atggctaggg caatcgaacc gcctatcaat ccgagaccgg cgagcaatat 2183701 tgtatctttc atttgattca tacgtcatca cctggtttat agactaaaga ggtgatattt 2183761 gatcacctct tataaaattt cagctaaaat ggcaagtatt tcttcatttt gctcttttgt 2183821 tccgatcgta atccggagtg atgtcgggaa acctaatgcg tttcctgacc ggacgatata 2183881 gcctttttcc agcagagcct gaaacagttc atcagcagga cgtttaaagt caattaacac 2183941 aaaatttgtc tgtgaagggt agcactttaa accatgagtt ttcgcaaaat cataatactg 2184001 ctgaaggcct gcattatttt gctcgacaca ggaagcaata aacgcttgat catcaagtgc 2184061 tgcaatcgcc gcagcctggc ccagacggct ggtattaaac ggctctctcg ccggctcaat 2184121 ctggcgaatc aggttctcgt cagcaattcc gtatccgact ctgagcgctg ccagaccgta 2184181 tgcctttgaa aatgtgcgca aaatcatcaa attggaatac ttgcttaaga gcggcacggt 2184241 ttccgggtaa tcctctgctg ttacatattc ataatatgct tcgtcaagaa cgacaaggac 2184301 acgagaagga acgcgctcca gaaatgcgag taattctcct tcagatgtat aagtgccagt 2184361 cggattattc gggctgcata tccaaacgac ttgtgtctgt tcgtcgatgg cttctaacat 2184421 ggcgtctaaa tcatgtgagc cgtcgggacg aagtgcaatt tcacgtactt cagcaccttc 2184481 aataaccgca ttatgtttat attgcggaaa agtgggggca gcagtaaccg tgtttgtttt 2184541 atcgtttaaa aatgcccggc agatgatctg tatgatttca tcagaaccgt tgccgaaaat 2184601 aagtgatgtt tcgctgacat tgaggtgctt actgagcctt gtccgcaaag cggcgctata 2184661 cccgtccggg taaagggcta gctgttgaat ctcatgatga agcgcctctt ttgcagcctc 2184721 tgaacagccg taaggattct cgtttgaagc aagcttcaca actttatcca agccatattc 2184781 tgatttcact gcttcaatcg gctttccagg ctgataaggc ttcagctgtt ttaaatgttc 2184841 tttgatacgc aaatcagtca cctcatttta aactgtacaa gccgctaaac gccattgcat 2184901 aatcctcaaa ctcctgcagc gcctgatttc tcgtttcagc gctgatgagc cggtccttta 2184961 attcttctat ttttctgacg agcgcacttc ccactacgac accgtcacta atttcattca 2185021 tctttatgac ctgttcacgg tttgatatac cgaaccctac agcaaccgga acagtgctga 2185081 gattcttcac agtacgaatg aacgggtaca cggatgaatt gaactcattg cggacaccgg 2185141 tcacacccag agaagataca cagtagacga acccctcggc ttgttcaata atggttttca 2185201 aacggctttc gcttgtcggc gcaactaaag aaatatacgt cacctcatgg cttttacatt 2185261 cctcttgaag gctgttgctt tcttctaatg gcagatccgg aacaagcaga ccgtcaatat 2185321 gattttcccg cagtaaagcg aaaaagtatt ctttgttcaa ttgtaacaca ggattataat 2185381 acgtaaagag gataatcgga atattcactc cgtttttttt catttctccg cctaattcga 2185441 ttgcctttac gatattcatt ccttgatcaa gcgcccgctt tgaagcccgc tggatcaccg 2185501 gaccgtctgc aagcgggtca gagtatgcaa caccaagctc caatgctgtg gcgcctgctt 2185561 tttggagtga cttcgccagt tcaatcgaaa cctcaggaac tggatcgccc gccgtaataa 2185621 acgggataaa caatttttct gatggttgaa gatccaattt aaacatgggc tttcacctct 2185681 tcttccaata cattcattaa tgtgttgaca tccttgtctc cccggcctga taaacagacg 2185741 agaatgagtt gaccgcgatc cattcctttg gcgagtttga atgctttcgc taacgcatgg 2185801 gcagattcga ttgccggcaa aatcccctct ttttctgaca aaagctttaa tgcatccacc 2185861 gcttcttcat cggttatact gtcataagtg acacggccgc ttttatgcaa atatgcatgc 2185921 tccggaccga ttccaggata gtcgagaccg gctgaaatag agtagggctc aataatttgc 2185981 ccgaactcat cctgaatgag ataagtcaat gaaccgtgaa taacccctac ggttcctttc 2186041 gaaatagtgg cggcatgaag aggtgtatca attccttttc ctgctgcttc agcgccgatc 2186101 agttcaacat cttcatttaa aaatgcctga aacataccca tcgcattgct tcctccgcct 2186161 acacatgcca ctactttatc aggcatagtg ccttcaatac gtttcaactg atccttcgct 2186221 tcctctccga tcattttttg aaattcacgg accacttgcg gataaggatg cgggccgaca 2186281 actgatccaa tcatataaaa gtgatcctca caatgctgaa cccagtaccg gatcgcctca 2186341 tttgtggcat ccttcaatgt tccgtttccg cttgttacag gcactacctc cgctccaaga 2186401 agcttcatgc ggaaaacgtt cagagactgg cgggcaacat cctcttcacc cataaacaca 2186461 gtacaggaaa agccgaattt ggctgcaact gttgcagcgg caacaccatg ctggccggca 2186521 ccggtttcag caatgatttt cgttttgccc atttttttag caagcagcgc ttgacctagc 2186581 gcattattga ttttatgaga acctgtatgg tttaaatctt ctcgtttcaa atagattttc 2186641 gcgccgccta agtattcagt gactcgatca gcgtatgtta atgcagtcgg gcgtccggaa 2186701 tagtccttta acagcttata atactcttca cgaaaagcgg gatcatcctt gatttgttta 2186761 aatgctgttt gtatttcatc taacggctgc atgagtgttt ccggaacaaa ctttccgcca 2186821 aaatcaccgt atctgcctat ttcattcgga tatggataca tatcggttca tcctttcttc 2186881 taaaagcctc atcagattct gatctttttg tccgtttttt tcaattccgc tggcaaggtc 2186941 aattccttct ggctgccatt tcaataggcg tgtgatgcta tccggattca cgccgccagc 2187001 gataaagcag cgtttaccaa tagccgcctg ctgatattcc ggcacacatt cccaagaaaa 2187061 tgcaacacca gttccgcctc tagacccttt tacagatgaa tcaatcacaa agccgtcaac 2187121 attatcttta aagcgggcta tttcttgagt tgtgttatct tgatggtgaa gcgccttcca 2187181 tatttcacag cctgtcagct tgcgaagagc agcagcatcc gccggttttt catcaccgtg 2187241 aagctgaatg acgtcgagct tcaagctctt ggcaatacgt gacatcgtct ctattgattc 2187301 attaacaaaa acacctgcaa cctgtttttc gacacgaact tggttcagcc attttttcac 2187361 atcttccgga gatacttttc gtttgctttc agcaaaaata aatcctaggt aatcagcctg 2187421 tgattccgcc gcaagctgca aatcctttag tgaccgaata ccgcaatatt ttaatgccgg 2187481 tttcttcaca acctcactcc ctaaacaaag catggattgc tttacgctga gaagtttgtc 2187541 tcatcaatga ttcaccgata agtacagctc gcgccccatg ttcattgaca aatgttaaat 2187601 gttctaaaga accgattccg ctttcgctga caagcaagga ttctttcgga acgagagatg 2187661 cgatttgttc tgtctgcttt acagatgttt caaacgtttt taggtttcga ttatttacgc 2187721 cgagaatgtc gggtgtgaac actttcaata tttgttctag cgttgatgca tcatgaacct 2187781 ccactaacac gtccatcccc ttttcacctg cttcaagata taattcatga aggtgtaagg 2187841 gatcaagcac ctcgccgatt aacaatatgg catccgctcc gattcttctt gattcctcta 2187901 cttgaagaga atcaataaaa tcttttctaa gtacaggaat cgaaacagca cgctttacgt 2187961 ctgataaata gctgttttcc ccttgaaaaa acggggtgtc tgttaaaacg gaaatcgcat 2188021 ctgccttcgc agcctcatag tcttttgcaa tctgcacagg tacaaaatcc tctttaataa 2188081 gcccttttga cggcgatgct ttcttcactt cggcaatcaa cccgataaac cgattcgggc 2188141 ttgccagcgc ctccttaaat gaacgtttct cgaaaggctg ctctaccggc agaaccagtg 2188201 ttttcacttc ttctttcttt tgtttgatga ttttttcaag catagatctc ttcctctttc 2188261 tgctttagtc gttcaagctg cgcggcagcg cctccgcttg taatcgtctc taacgccagc 2188321 tccgttcctt ccttcagtga ggcggtaatt cccgccgtgt aaatcgcagc acccgcatta 2188381 aaagccgtaa tagataaagc ggaactgctg cttttatttt caaaaatatt ctgaatgaga 2188441 taagcgctct ctttcggaga ctgcacctgt aaatcttcaa gtctgccatt tgtgaaaccg 2188501 aaatcttcgg gtgaaacggt atactcccgg cgctctccgt cctttaattc aatcacgtcg 2188561 gtcggtgctg taattgaaag ctcatctaaa ccgtcacggc ttgatacaaa cataacgtgc 2188621 ttcggctgaa acgtctccag tgcgcttgcc atcagtccag ctttttcaac agaatagacc 2188681 ccaatcacct gacgcttcgc ctgtaaagga ttgctgagcg gcccaagcag attaaatacc 2188741 gttctgaaac ctagctcttt tctagtacct gctacatgtt tcatagacga atggtaaagc 2188801 ggcgcaaaaa gaaatcccat gttgtttgtt tcaatgctgc ttttgacctt ttcgggagtg 2188861 gtttgaatag aaacctctag ctcctctaaa acatcagcgc ttccgctttt agaagagaca 2188921 gagcgattgc catgcttagc gattttcgca ccagctgccg aggcaacaat tgccgaggcc 2188981 gttgagatat taaaagtgga aataccgtct ccccctgttc cgcatgtatc aacaatatca 2189041 ggaagtccat cgactgtaag agcgtgtgcc cgcattgcct tcacaaaacc cgcaagctct 2189101 tctggcgtct ccccccgatg agcaagaatt gacaatatcc cccccatttc agaaggagtc 2189161 atttccgctg ccatcatcat attcatcagc gtttcagcct caccggcagt aagggttttt 2189221 ccgtcaacgc acaattgtag aaatctgttc atcagcttta tcctccttgc tatgaaacat 2189281 gtcttctgca atatgaatcg ttttcagcag cgcaccggct ttattacagc tttcttcgta 2189341 ttcggcttcc ggaacagaat cagcaacaat gccagcacct gcctgtatcg atgcaacacc 2189401 gttctttaca ctcatcgtgc gaatcgtaat acaagagtcg atattcccgt caaacccaat 2189461 gtaggcaata caccctccgt atgtctctct cggtgttggc tcgagttctt gcaaaagctg 2189521 catggcacgg attttgggtg cgcctgttaa agtccccgcc gggaaagcag acatcagtgc 2189581 atcgacagga tgaacccctt ttttcaatcg gcctgtaacc accgagataa tgtgcatgac 2189641 atgtgaaaag gaaacaattt ttgtgaactc cggcacagaa acagaaccat actctgctac 2189701 tctgccgata tcgtttcggg caagatcaac gagcatgtaa tgctccgctt tttctttttc 2189761 atccttcatg agctcaacct tcagtctctc atcttcagct ttgtctgcac cgcgttttct 2189821 cgtaccggca atcggatgga tttctaagtg cccgtcttga acgtgtatta accgttccgg 2189881 agagctgccg actatttctc tgtctagcag tttcatataa tacatatacg gcgaaggatt 2189941 gacgatccta agcactcggt ataactcaaa agcatctgct tttatcggca cctcaaattt 2190001 ttgtgataaa acaccctgga agatatcgcc tgcttttata tagcttttga ttttttctac 2190061 atcagccata aaagccgatt tttcataatt agaagatact gtctcaaagc tgggtgtctt 2190121 gtatgaatca gcagaaagaa acagctcttt tatgtttttt tggtccatca ttttttcaat 2190181 gagattttga agctccagat gattttgatg gaatacatcc attttttcgt tttttgtttc 2190241 ctctccagtg agccttgcat attggataaa gtggacgttt ttggtttcat gatcatacgc 2190301 aattaatgtc cggcaaacaa acagcataca cttttccatg tctgtttctt tggtatgcga 2190361 aggaacagaa ggctcaatca gcgggatcat atcatagctt aagtacccga cagctccgcc 2190421 gacaaaagga atgccaagct caggtgtttt gattttgtat gtggtattca tccagttcag 2190481 cacttctttt agttcatttc ctgtgtaaag agatttgctg tcctgatcag cggccgaaaa 2190541 acggccctgc tcttctttaa ttgtgagaaa tggattcagg ccgataaacg aatatctgga 2190601 ccaagtggat gtatcgtcct tgctttcaag aagatacgta atctccctgt caagcttctc 2190661 tatcatttga atgggtgtca gtgtatcgac tgtgaaggtc tccacaatcg gtatcgtgtg 2190721 gtgggacaag ctgtcctcta aaaatgcgga aatgtttgat tggaaattca ttgctctcac 2190781 tccttatggc aaggagaatg agaagatggc atgagaggat aaaatactat ataacaaata 2190841 aacccaaaag aaagacttct tttgggtaga ataaacataa tgtctcagct caactaaact 2190901 cattctctgc taccctattc tctaactcaa ctcattctaa ttgctttata cacactcttg 2190961 tgtatttcta agctgttctt atcgtattac aattcagtat tttttgtcaa tgataaatcg 2191021 ggcctcaata cgacaacttt ttctaaatat acatgtctga tctgatcctg agggacatct 2191081 gtctggaccg tcatcatgac tcttatgcac tttttcagac cgcctgttac gtccatttcc 2191141 tgcatacatg ttaccggtac atactgccat cctgaaagct cgcgaacagc ttttgccggg 2191201 aaaacagcgt gcaaatcagg tgtagccgac agaagcattt gaacaacatc ttccggtttt 2191261 gtatgatttt cttctatgat tttctctaac agctgtttag ttttttgtaa aatttcttct 2191321 tcagtatccc gttcaactgt agttgctccg cgaattccgc gaatcatcat gatgtctcct 2191381 ccaatcgcca tttgttcagc cagctctcaa gttcatttct ggaaaatgta tgatcagcaa 2191441 ctttccctaa ttcgttgagc acaataaact gaatcttccc gccacgggtt ttcttatcat 2191501 tcatcatacg gttcaagaga accgaagttt ccgtctcttt tctgatttga cttggataac 2191561 ccaggctttt tagccagctg accaaacgtt ttctgtccat ttcacagcct acagtctttt 2191621 cgcttatata taaagcaaac tgcattccga gggctacggc atcaccgtga gtgatctgcc 2191681 catatccata ttccgcctca acggcatggc cgagcgtatg cccaaagttt aagtaagctc 2191741 ttatcccctc ttctttttca tcctgctgaa cgacagacgc tttaattgaa atgcctttaa 2191801 aaatcatgtc attcagctga tcattagtga tatcacgcag tgagtggata ttcagcagct 2191861 cctccagaaa cgctctgtca tagataaaag cgtgtttaat cacttctgcc attccggacc 2191921 taagctcttt ttcaggcaga gaacgcagga aatctgtatc atagagcacg gctttcggct 2191981 gataaaacgc accgattaga ttttttccaa gcggatggtt cacggctact tttcctccga 2192041 ctgcgctgtc atgcgccaag agcgtcgtag gcatttggat gaaatcaatg ccgcgcataa 2192101 aagtggcagc cacaaaaccg gcaagatccc ctacaacacc gccaccgaat gcgatgatgc 2192161 atgaggagcg atccatatga aaacgaatcg cttcactctg caattttgtg tacatgtcca 2192221 tggattttgc ctgctctcca ctcggtaccg tcactttttt cacaggccat ttttcttgca 2192281 gcaaatggag catttcatca ccatacaggc ggtccacttc ttcatccgtg acaaacataa 2192341 tccttgttaa aggcctgttt aaagaggtta atagttcgca agcctttttt ctgatacctt 2192401 gtccgataaa aacaggatat gacgaggaag cagtttgaac atgcagtgtc ttcattaaaa 2192461 ttccctcgac agttttctca tattctccac attttctcta atgcggtcaa tttgatctaa 2192521 tccgaattgt tcaacgactg cgttcgcaat ttcccaagcg acagccgctt cagcgactac 2192581 acttgccgca ggaacagcac agctgtctga acgttcaatg ctggcagaaa acggttcttt 2192641 cgtttcaata tcgacacttt tcagcggttt atacaaagtc ggaatcggct tcatgactcc 2192701 gcggacaaca atcggcatcc ctgtcgtcat gccgccttcc agtccgccaa gtctgttagt 2192761 agcacgggtg tatccttttt cctcgtccca aatgatctcg tcatggactt cgcttccatt 2192821 tcgccctgct gcctcaaatc cgatgccgaa ttccacacct ttaaatgcgt taattgacag 2192881 aacagcggca gcaagcttgc tatccagctt gcggtcataa tggacatagc tgcccacgcc 2192941 taccggcatt ccctcgacaa tgacttctac tattccgccg atggaatctc cgtttgcctt 2193001 tgcttcatca atggcagcca tcattttttt gcctgcctct tcatcgtagc atctgacagg 2193061 agactcttcc gttacacgct gcaagtcttc aattgacgta tactctgttt tttcagcttt 2193121 aacagcgcca atttgcaaca cgtggcccgc caccttaatg ccaagctcag aaagaatctt 2193181 tttagctaca gcccctgccg ccactctgac agttgtttcc cttgctgaag aacgctcaag 2193241 cacatttctc atatcacgat gattatattt aattgcaccg tttaagtcag cgtgcccagg 2193301 tctcggtctg gaaatctggc gcttcatttc cttttcttca tcttctgtaa tcggagcggc 2193361 gcccatgatt tttgtccaat gcttccaatc gttattttca actacgagag caattggcga 2193421 accgagtgta cgtgcatggc gcaccccgct cataattttg gcctggtctt tttcgatctg 2193481 catgcggcgg ccgcggccgt gtcctttttg gcgtctggca agctcaaaat tgatatcttc 2193541 ctccgttatg taaagcccgg caggtacacc ctcaataatg gttgtcagtt gggggccgtg 2193601 tgattctccg gctgttaaat atctcatgac ttcttctccc ttcatcgcat taacgctttt 2193661 aagtaagact actataacat atttttcagc aaaaagtcag tctatctttt ttgataaaag 2193721 aatgtatcgg ctgggactag gccaaatttc tcgggattga agatttgctc ggtgctgccg 2193781 acaaaaagaa ctccattctt cttcaagcta tgtgccattt ttaaatacag ctcttccttc 2193841 gcgctttctg taaaataaat aaatacattg cggcacacga ttaagtcaaa gtcttgttca 2193901 taacgatccg ccagcaaatt gtgctttttg aatgtaatat tctttttgat ttccgttttc 2193961 acttcataac ttctatttgc gttttgcgta aaataacgat ctttcacaga tagcggcact 2194021 tcctgtaaag accgctcctg ataaacgcct tttttcgctt tttccaatgc tttttcatca 2194081 atatccgtcg ctaaaatctg atagcccgga agaccttttt gctggtccaa aagcatggca 2194141 agcgtgtatg gctcctcccc cgttgagcag gcggcactcc aaatttttaa aggcctagag 2194201 gtcttgatta acggcagaat tgcagtctca agaacttccc atcttttata attacgataa 2194261 aattctgaaa cattgatcgt cattctgtcc aatgtttcat ttaagagagc ttgatccttt 2194321 tccaatgccg cagcaaagtc cttaaagctt tggaacccct ttttctcata aagtgacgtt 2194381 agccttctct tcatttgtgc ttctttatat agtgttaaat cgactccggt taattgtttc 2194441 catttcgttg taaatacgct gtatgtatcc atctctactc tcccagtctc gctgtctttt 2194501 tgtcctagta tagcttgttt tatcaggaaa ttgtattgtt tcaataaaaa aatcagcttt 2194561 tcagctgatt ttagatcgtt gggaaaggca gaggtctgat gcacactgcc attcaaccct 2194621 ttattcactt taatgtaaac ctttacaaaa cagaacaaaa accggcggcg ttatatgttg 2194681 ccggctctgt tgcttatttt cacaatgatt aatagatcca gcctgccata agctgctgat 2194741 atgatactaa ttcttcattc ttaaagaaaa tgttaatctc gcgttctgca ctttcgagag 2194801 aatcagagcc gtggatgatg ttttttccga caaacatgcc ataatcccca cgaatcgtac 2194861 caggtaaagc ttctttaggg tttgttttcc cgatcagctg tctcgtcact tcaatgacat 2194921 tttcgccttc ccacaccatt gcgaatacag gtcctgaagt aataaactca acgagctctc 2194981 cgaagaaagg cttaccttga tgttcggcgt agtgtttctc agccatttgt tcagtcactc 2195041 tcattaactt ggcgccagct aattgtaagc ccttacgttc gaatctagat aaaatgtccc 2195101 caatgagctg acgttggaca ccgtctggtt tcaccatgat aaaagtcttt tccatcatat 2195161 tctccacccc atcattatgt atgtataggc tttcacactg cacaccgaaa tcgtaacatc 2195221 tttctgataa ttaatcaatc cggggcggag aaatttctta atatctacaa aaattaaaat 2195281 tttcttttac cgatatattt tgcgatggct gcaagagacg agcgtgcgcg ccctcgagga 2195341 agcgtgttta atttctgaaa agctttctgc agatacattt cgcttactgc catagatgct 2195401 tcaattgcat ctgttttttt gatttcttca atgattggtt caagctgttc ctgcgttgtc 2195461 tcactgttaa tcaatttaag ctggtttttt aatgcaggat ttttcagggc atacagcact 2195521 ggcaatgtga cgtttccttg aagcaaatct cctcctacgg gtttacccag ctcttcctca 2195581 gttgaagtaa aatcaagaat atcatcaata atctgataag acatgccgac gtaataccca 2195641 aaccagtaca atgccttatg aatcttctca tcagctccag acgcaatggc accaagctgg 2195701 cagctgaccg cgatcaagag agctgttttt cttttgatac ggcggagata cgttctgaga 2195761 ttttgttcca tgttgtattt gtctttgatc tgctcaattt cccctagaca aacttcaacg 2195821 atcgtctgtg acaaaatcct atgggctttc ggttcgttaa ttctcgtcat catttcaaga 2195881 gatcccgcaa gcatataatc gcctgtgtac atcgcaatac gattgtccca ctttgctttg 2195941 attgtcggtt ttcctcggcg aagctctgca tcatcaatga catcatcatg aaccaaagat 2196001 gccatgtgaa tcatttccag agtgacggcg acatatttaa tcttattaat atcataatcg 2196061 ccaaacatgc cagaaagcag cacgaaaaca ggccgaatac gtttccctcc ggcctgcagc 2196121 aggtgaagac ctgcctcgct taaaagcggg taatcggaac gtacggtttg ttcaagttct 2196181 ctttcgatta catcaatatc gtcatttaaa aaagagtagg ccattttaaa tttcatatca 2196241 ttcacccaaa catctgtgtt ttcatttcca tccgatatgc gtggcagcga ctccgccagt 2196301 aaacgaatga tatttaacat ttttcaggcc cgcctcttca aacaggcctg ccagttcctt 2196361 cattccaggg aaatctctgg ctgattcttg aagccaagaa tattctttat agctcttcgc 2196421 aaacagtttc ccgaaaaacg gcataatata cttaaagtac ataaagtaag cctgtctgaa 2196481 tccgaacatt tccggctggg acgtttccag acataccacc tgcccgcccg gcttcactac 2196541 acgtctcatc tctttcagta cagtcaagta atcagggaca ttgcggagtc cgaagccaat 2196601 ggtgacataa tcaaatgtat catcatcaaa aggaagctcc atcgcatttc cgtgcagcag 2196661 ttcaatttgg ctgaatccgc cgtcttttac tttctgctcg ccgacactca gcatattttc 2196721 actgaaatcc aagcccttga tctcgccgct tttgcctgcc gcttttgcaa gagcgatcgt 2196781 ccagtcagcc gttccgcagc agacatcaag tgcttttgcg ccttccttta cattcatgat 2196841 gcgcatcgtt ttgtcgcgcc attttttatg ctgctgaaaa ctgatgacag agttcatttg 2196901 gtcataattt ttatatattt tttcaaatac tccgtgtacg cgctgttctt ttgagtcctg 2196961 cataatggtt tacccttctt ccactttctg atgataggtt tgatcttggc tgattgtctt 2197021 cagacggttt attaaaatgt tctgaatagg tgaatttaga ggcagaagtg actcaatgct 2197081 gtttttcgct tttttaaaac aatcttctaa tatctcttct tttgtttttc ccagctgtat 2197141 aaaactgccg atcacatcca gaaatgcatc atttccgttc ataagccgct taaatacaaa 2197201 aaaatcactc gacagctttt tccagcgcgg gaggttgaag tgttccgcca cacgatggaa 2197261 taaagctgat tcaacgatgc cgacactttc gaaaaaatcg ttttcgtcct tgaaagaacg 2197321 gtcatacaga cgaattttat gttcgttgat ttctttaatg gctgtagcaa gcgtccgaat 2197381 catgtagata tccttcattt cagatagtaa agagtagtac agcccgctga aataatcgcc 2197441 cgcgagaaca gtcaattggc ggtttttgtt ttcgtctcgt tttatgactc tagctgtcgt 2197501 cacttcatca tgggtatcaa gggcgctttg tacaagcatc gctgttacaa tataattttc 2197561 tctgtcgttg ttttttatgt cggcttcttc aaataaagca tgaaaaagaa gaagcttatc 2197621 ctcatcaatt ttcggcgcag aaatatgctt cgctaaataa ggatgagaca gcttttgttt 2197681 taatttcgtg ttcagattgg ctaaagttcc gtagatgtct tgcaaaaata tcacccttgt 2197741 ccccaaattc acatttattt cttaatctat gtatgagttt tatcttttca ttcgcttacg 2197801 caggtatcat tatagcataa aaaaaagaaa ttggctgtat cctcccgctg tttgcgagca 2197861 tttgctttta acagcgggga cagccagctt attttttttc gcttttcatt tctccgtacg 2197921 cggtttgaat cagtgcctct cctctgactt taatggcaga agtatgctct gtaaactgag 2197981 cgatgatcac ttctcccttg tcgagttttt cggaatggtg aaactttgtg tctgttcctc 2198041 ttgtcaggcc gatcacattc actccgtcct caacggcttt aatgacgaca aaatcacttg 2198101 aatgcttttg gttcatttat agcaccctct atctttatta gtcctggcgt ttaatatgtt 2198161 ccaatacttc tgcacgggca gcggcatcat ctttaaaaac gcctctgact gctgaagtca 2198221 cagttttcgc acccggtttt cttacaccgc gcatcgtcat gcacatgtgt tccgcttcaa 2198281 ccactaccat tacgccatgc ggatcaagcg tttctacgat gctttctgca attgtagaag 2198341 tgatgcgttc ctgaagctgc gggcgctttg caacggcttc aacggcacgt gccagtttgc 2198401 tgagtcctgt gacctttccg cctcgcggga tatatgcaac atgtgctttt ccataaaagg 2198461 gaacaaggtg atgctcacac atagaatgaa acgctatatc ttttacaaga acaagctcct 2198521 catggttttc accgaagata gtctggaaat gttcttttgg atcttcattc aagccggaga 2198581 atacttcggc atacatcttt gcgactcttt tcggagtatc aagaagccct tctctattcg 2198641 ggtcttctcc gatcgcttct aaaatttgac gaacagcttg ttcgatttgc tctttattaa 2198701 cttctttcat gttctatgtc ctccaccaat gaatacattt aatttcgatt ctagcacata 2198761 tgccccgcta aaagcaaagt gaatgccctg tcaggaagcc catgctcttg aaatatgaaa 2198821 agccccttag aaaggggctt ttctgtgaag aaataaagtg tatgtaagct agatgcatac 2198881 acgatctata ttcacaatta ttttccggca actgcgtctt taagcgcttt acctggtttg 2198941 aaagcaggta ctttgcttgc tggaatttcg atttcttcac ctgtttgagg attgcgtcct 2199001 ttacgtgcag aacgttcacg cacctcgaag ttaccaaaac cgatcagttg gattttatca 2199061 ccgtttttaa gtgcatctaa gatcgtatca aaaacagagt caactgcttt tgtagcgtct 2199121 tttttagaca attcgcttgc ttctgcaacc gcattgataa gttctgtttt gttcatgcct 2199181 ttcacctcct cccaaaagga tacattcagt tcgtttatta tcatttcttc acagttcagt 2199241 ctgattctaa acctgtctca gaaaaaaatg agagcaagta agagaaagac aattaaacgg 2199301 ctttttaaga aaaactgcac tctgaggaat gtttgtccaa caaagtgaag aatttctgta 2199361 tgtagagtaa cacatataaa aagccatatc aagcatttta aagcgtcaat cccttgctcg 2199421 tcaaggattt aaggtgattt accgaacgaa tattcctttt tttccttttt tcatcctatt 2199481 ccttgatcct tttccattat taagagcaaa gaaaaaagac ctcccattct ataaagaggt 2199541 ctaccggtat tacaggatga tggcgattaa gccgccagag ccttcgttta tgattctttc 2199601 taatgtttct tttaatttat accgtgcgtt ttcaggcatc aatgacagct ttgcctgaat 2199661 cccttctctc acaattgagc tcagcgacct tccgaagata tcggaattcc agatggagag 2199721 cggatcatcc tcaaagtcct gcattaaata gcgtacaagc tcttcacttt gtttttccgt 2199781 tccgataatc ggggcgaatt cgctttcgac atctactttg atcatatgga tcgacggagc 2199841 gacagctttc agcctcacac cgaatcgcga gccctgcctt ataatttccg gctcatcgag 2199901 actcatatca gctaaagcag gcgctgcaat gccgtatccc gtctgtttga ccatttttaa 2199961 ggcatcagac acttgatcat attctgtttt cgcatgggcg aagtcttgca tgagctcaag 2200021 cagatggtct cttcctctga tttcgacgcc cacaacttct tttaggattt gatcatatag 2200081 atgatcaggc gcgtacaaat caatttctgc caccccttgg cccagctcaa ttccggctaa 2200141 tccggcactt tcaatgaatt caaactcgct gaattggccg acaaccctgt ctacgtcccg 2200201 gagccgttta atatccttaa ccgtttcctt cacggactcc tgatagcttt cacgcaacca 2200261 atggttttct ttcagcacca ttacccagct tgggagattg acattcactt ctagcaccgg 2200321 aaactcgtag agggcctctc tgagcacact cagcacatct gattcccgca tgctctctac 2200381 actcattgcc aataccggga tatcatattt ttcgcttaaa tcctggcgca tggcttccgt 2200441 ttccgggtga tacggcctga ctgagttgat gaccataata aaaggtttgc caacctcttt 2200501 cagctcttca atgactcttt cttcagcctc tatatagtca cttctggcga tatctccaat 2200561 ggtgccgtct gtcgtaatga caactccgat ggtcgagtgt tcttgaatga cttttcgtgt 2200621 gccgatttca gcagcctcat gaaatgggat cggttcttcg taccaaggcg tattgatcat 2200681 ccgcggcccg ttttcatctt catatccttt agcgccgggc actgtgtaac ctacacaatc 2200741 tactaatctt atattcacat cgagtccgtc tgacacatga acagacatcg cctgattcgg 2200801 aacaaattta ggctctgtag tcataatggt tttgccggct gcgctctgcg gcagttcatc 2200861 ctgcgctcgg gcccggtctg cttcgttact gatattcggg agcaccacaa gctccataaa 2200921 ttttttaatg aacgtggatt ttcctgtacg gacagcacct acgactccta agtatatatc 2200981 gcctcctgtt cgttcagcga tatccttgaa aatatcgacc ttttccaagt gatcccctcc 2201041 cggacttcct atccttttca attttattaa gctctttcaa tcaaacacag gacactatat 2201101 gtgtatgacg ttgtcctatt tgaatatgac atctttagaa aatttctcat cctcaatcta 2201161 ttaatataaa aaaacctttc tccctatttg tatgcaaggg agaaaggttc attccttttt 2201221 catatcattt tctaaaaaaa caggttcctg tttgtcattt accgtatatt ttacagaaaa 2201281 cgcggggaca aagggggttt catgccaaat catatcctgg atttcagtcc cgggtttaaa 2201341 cgtttttttg ctttttttga ggcaagaagc cagctcagtc cggtaatcgg catatatttc 2201401 tccgtctccg tcaatcataa gcggcaagga attccctgag attgggcttg tcactgtaag 2201461 agagctgcca tccccaagct tcttctcatc gagtgtaaat aaatcacgag atagcacatc 2201521 cttgtaaggc ggatattgat gctcctgacg atacatttgg atgcgcaatt tcacatcgcg 2201581 aattttttct gccatcttta gatcaattaa tttaacagtc ggatcgttct ctacgtcaac 2201641 aagcacgtat tgatagtctc ccccgctttc aaatgccgta cttggaggtt cagctatgta 2201701 tcttggcgct aaccggttaa agtctatcgg atatttttga tatagcggtg tcgacatatc 2201761 tttggtttga ataggaagca gccctccatt tgccttttga aattcatcaa cagcagattg 2201821 aacctgcttt agctggtctt gataaggaat ggcatgcaca ctgcttttcc gttcatttgg 2201881 atataaacat ccggataaaa acacgactgc cgcaaaaatg attgcgcact tcagtttacc 2201941 catacagcac ttccttttac agctttattc attgacaggg ccgctaaaaa ccacgacaaa 2202001 cacaataatt ccagatatga gcatacacat gtatgcgaat gatgaaatcg caatcttcaa 2202061 aaaacggttt tggcacttaa agcggcttaa atagatggaa gctacagcca gaaacatcag 2202121 acccatggac cctagagcaa accacatttt catcaatgcc agattcaatg acgtgcgcct 2202181 ccccgatatg taagatataa gcgttatatt atattttaat atacagcgcc ggaaaagatc 2202241 aaccagattt tccatccatt gatagaacaa aaaaactgaa gcaaagaggg ggaccttcgc 2202301 ttcagtcaac ttgactatat tcacctgcac gtttaagaaa cactctcttg gacttcgatg 2202361 ctatagtatg cgacttggca tacagatgca tcctctattg cctaaatcgg caaaatgttt 2202421 caggagatcc caagacttgg gtgttcttct gtttttcggg ctttcgttca attaagatat 2202481 gcgattcacc atttgattga cacttttact tcacttgatt ttcaaacgta tttaccaaat 2202541 cctccatctc gtgggttttc cctctcgcca ttaaagattc aacagcggtt tccacttttt 2202601 gtccgttgaa taggacctga tggagagctt ctgtaatcgg cattttaaca tcatatttct 2202661 tcgaaagctg ataagccgct ttcgtcgtgc ggacgccttc gactaccatt cccatctctt 2202721 caagaacatc ttcaagcttg tacccttttc cgagcaaatt gcccgcacgc cagtttctgg 2202781 aatgaacact tgtgcacgtc acaatcagat cgcctactcc tgtcaatcca gagaacgtca 2202841 agggatttcc gcccattttc gttccgagtc tcgcgatttc ggcaagtccg cgtgtaatca 2202901 aagcagcttt ggcattgtca ccgtacccta aaccatctgt aattcctgca gcaagggcaa 2202961 taatattttt taaagcccct ccgatttcaa ctccgataat gtcaggattt gtgtacaccc 2203021 gaaaattgtg attaataaat agatcctgca cctcttctgc tgccctcatg ctctttgaag 2203081 atgcagtaac agttgtgggg tgccgcagcc ctacttcttc cgcatgactc gggccggaaa 2203141 ggacaacgat atcttttctg acatcactcg ggagctcaat ttccataatt tcagaaatgc 2203201 gcagaagtga atctggctca atacccttgc tgacatgaac aaagactgcc tttttcgtta 2203261 taaaagggac agcctgtctc agcacttccc gaattgcttt tgtcgggacc gcaacgataa 2203321 tgacatctgc gtctgaaaca gcctctttca tatctgttgt tcctttaatg gatgtagaca 2203381 gcttaacatt cggcaaataa tctttgtttt catgcaactc attaatttga tgaattaaat 2203441 ctgcacggtg agcccacaca cacacttcat ttccattatc agttagaact aaagccagtg 2203501 ctgttcccca actccccgct ccaagcattg tgactttttt catgtttgat tcacaccttt 2203561 ttattttcta gctcttgcaa atattttgat tggtgtcccc tcaaaaccga acgcgtctct 2203621 gattcggttt tctaaaaacc gttcgtatga aaaatgcatc agttccggat cgtttacaaa 2203681 cacaacgaag cttggcggct ttaccgacac ttgagtcgca tagtaaattt tcaaacgaga 2203741 accgttatga gtcggtgtcg gattcattgc cacagcgtcc atgatgacat catttaagac 2203801 gtttgtttga actcgaagtg aatgattttc actagctttg ataatcgcag gcatcagagt 2203861 atggatccgt tttttcgtta aggcagacat aaataggatt ggcgcataat ccagaaattg 2203921 aaaatgatcg cgaatatttt cttcaaattc tttcatcgtg ctctcatctt tgtcaacagc 2203981 atcccatttg tttacgacga tgacgacggc cttgcccgct tcgtgtgcat aaccggcgat 2204041 acgcttgtcc tgttcaataa tgccttcttc gccatccagc acaaccgcca cgacttctga 2204101 gcggtcaatc gcttttagcg cccgcagtac actatacttc tcagtcgttt catagacttt 2204161 cccttttttt cgcatacctg cagtatcgac aatgacaaac tcctgctggt tgtaagtaaa 2204221 tgacgtatca acagcatctc ttgtcgttcc agccacgttg ctgacaataa cgcgttcttc 2204281 gccgagcatc gcattcacaa gtgaagactt tccgacattt ggacgtccga tcagacagaa 2204341 ttgaataact tcttcattgt atttcgtttc aggaatgttt ttaaaatgct ctgcaacggc 2204401 atccagtaaa tcacccagtc cgagtccgtg tgttcccgaa attggatacg gctcgccaaa 2204461 gcctagcgaa taaaaatcat aaatattcgc tctcatttct gtgttatcca gtttattaac 2204521 cgctaaaaca acaggctttt ttgtgcggta caaaattttc gccacttctt catcagcagc 2204581 tgtcacgcct tcacggccgt tcaccataaa aataatcacg tccgcttcat ccatggcgat 2204641 ttcagcttgc tggcgaatct gcgctaaaaa cggctcatca ccgatatcaa taccgcccgt 2204701 atcaatcaaa ttaaaatcat aattcagcca ttcagccgag ctgtatatcc gatcccttgt 2204761 cacgccaggg gtatcttcta ctattgaaat tctttctccc gcaatccggt taaagattgt 2204821 ggattttcct acatttggtc tcccgacaat ggctacgaca ggtttaccca tagtaccctt 2204881 cctttcaatc cagccgcttt catttttaca taaattttca accggttatt aaaatcattt 2204941 cattcacttt tatgaaaaga aacccttcag aggaagggct taactcattt attatatcag 2205001 tttttactgg gatcacaact attcttaaaa atgtttcacg atcaaataca cgtcatctcc 2205061 gattctgtga gctattccat caaggatcgc ctcaagattt ttagcgaaaa gctccatctc 2205121 cttttggtca ttgcaaaaaa agacaggtgc tccccctgca acccgatttc gatttgtcgt 2205181 gattacagac aaaatcactt tcgtaagaga ttcactcatc ctatcacctt atcctgattc 2205241 ttgataaatt cagtcggcat tctaatcgca ttttccaggg ttggaacatt gctaataatt 2205301 tgaacagccg tttcgggatg gtgaatttgc gggagaacaa atactgccac tctcccatca 2205361 tttaaatccc gttttgcaat tggtgtcaaa gatggctctc ctgaatcccg ataaaccccg 2205421 agcacattgg aaacatcaaa taaaatggcc tgacgctgcc ctaaatttgc tatcgtcgct 2205481 gctgaattaa agtttttcgg cgtcaaaata aagcccatgc catgctttaa aatcagttcc 2205541 tgtttctctg gaagcccgat attcatcata taaatattat caacaaacag tcccggaccg 2205601 tcaaagcgcg gctttatgta ctcgatatct acaatatcct tcaacacact gcccgacata 2205661 aacttcatgg ccagtaaaaa acaaacgaca gccgctatga ctgcagccca gatggataaa 2205721 aacacatacg cagaggttgt caaaagcgct gtaaagatca caatataatt tctgctttca 2205781 aacgcaatgg caatcccctc aatatatgtg cttccccttg agacaagttc atacgaatcc 2205841 atttgcgtca atgtgttccg ctccatgttt cggacatctc taaattgcgt cgctgccaat 2205901 gttaaaaatg tgatggccgt aaattcctcc tgcaaaagcg ccggcataat aattgcacct 2205961 aaaccagccg ctatcaaccc cagtgcgatg tgaatcactt tcccatgaac ataggtcgga 2206021 tactggcggt aatccgtttt cagcatataa agccttgtcg caattccggc aatgacccca 2206081 gcaataatcg gatagatgta atcactcatg acattttggt agctcctttg tttgatcttt 2206141 tgcttttctg accaatctgg cttgcgaggt gttcgtattt agatatgcca aacagcaata 2206201 tcatccccgc agaacacgca ttcagccatt gaaagccgcc gacagccata gccccggcca 2206261 acttctggat cacaaatgaa tacaccagtt cgccttggca catccctagg acaaataaga 2206321 caagctgctt ctcaaaattc ctttcaacag aagctgttaa aagcactatt aatataacag 2206381 cagcccactc aggttttatg atgaaccaaa ccgggtcata taatgcaaaa agataaacaa 2206441 acgcatacgc ggcaacaagc gtcagataga ccatgatgta acgaaaacga tacattccca 2206501 aatacccggc atagacacat ccgcaaacga aaaacatcaa atatgcagca ttcagggaaa 2206561 aatataaagc gatgtcatgt atgcttagaa taatattagt taaaataaag acagagacgg 2206621 caattcgtct tttcgtcttt tcaaaaataa atgttgtcag aacccacaga aaccacattg 2206681 accaatagta ataaaattgt tccattttac ttcctccata ttcccagtat ggagttcaag 2206741 cacatttttt aaacaatcga tctcacatta aggagtatga tcatgggaaa agacagacaa 2206801 gagaaaaaac tcaaagcttc aggcagagtc gaatcagatc gcgaccagtc cattcactat 2206861 gacggagcga caagccttga acaaaacgga agattcaaaa agcgaaaatc ataatacaaa 2206921 aagcccaaac cacatatggt tttgggcttt tatcatttat cgcacactat agcttgatgt 2206981 attgacccct ctctctgtga gccaatgatg ggtttcacct ttgatcacaa ggggcgcctt 2207041 ttgtaaatcg gcaattgttc tggcacccag cacggtcata atcaacttta attcctcaag 2207101 gatcagctga atctcctcaa gcagtccttc ctcaccgctg tcagtcagcg cttttaaaaa 2207161 atgccctgcc attccggtgc aagaggcccc cagcgcaatt gcctttgcca cgtcaagcgc 2207221 atcttgcaga ccgccagagg cgatcatggt gcttgcagga aactcagagc ggatttccgc 2207281 caaacttgca gctgtcgaaa tgccccacga attaaaaaag gagatttgcc gctgtcttcg 2207341 gagattttcg attttcgaga aatttgttcc cccgtaaccg ccaatgtcaa cagctgcagc 2207401 accagcttca tacagctttc ctgctgatgc tttgctcata ccgaagccga cttctttcac 2207461 aatgaccggt acactgaccc ggctgcaaat ttgttcaatg cgtttcaatg cgccgctaaa 2207521 gcttctgtcc ccttcaggca tcacaatttc ctgaatcaca ttgaggtgga tctgcagtgc 2207581 gtttgctcca atcatctcaa cggcttcctt tgcctgagca gccgttgcct cgcttcccag 2207641 gttggcaaaa atcagcccgt ttgggttttc ctttcgaaca atttcatagg aaagacgctc 2207701 tgatggatct tttaatgctg acatttgcga tcccacagca aggggaattc cagcctgaga 2207761 agccgctcgc gcaagcgatt tattaatctc atatgtaagt tttccgccgc cgccagtcat 2207821 tgcattgata aaaatcggcg aactgcttga aagttcgccg atttttgtgg aaatatctac 2207881 ttgttctaat gcaagatcgg gcagactgac gtgaacaaac gtaatatcat caagacctgt 2207941 ttcccgcttc tggccgatgg acaaggcatg attgatgtgt tgtctttttc gttctgctcg 2208001 agtcacgttt atcaccaatt attttagttt attcagctta tctccgatca gatctccaag 2208061 ctggaagcca gtgcttgttt cttccttcgc ttgatattga cggtaatctt cctggtcagc 2208121 tttaggcgtt tcttcaagtt cacgcatgct taatgaaatg cgctcctcat tttcattcac 2208181 atcaagaacc ttcactttta cagtctgtcc ttcttcaagg acttcatgcg gcgtgccgat 2208241 gtgtttattg gaaatttgag aaatatgaac gagaccttca acacctggaa ggatttcaac 2208301 aaaggcaccg aagcttacaa gacgctgtac agttccttca agcacatcgc caggcttcac 2208361 tttttcgccg atttggttcc aaggtccagg cagtgtatct ttgatcgata aagaaatacg 2208421 ttcattatca cggtcaaccg ataacacttt cacttttact tcttgtccct cttcaacaac 2208481 gtcagacggc ttctctacat gagagtggga aagctgtgaa atgtgtacaa gtccgtcgat 2208541 gccgccaata tcaacaaacg cgccaaagtc agtcaggcgc tgtactttgc catcaagtac 2208601 acttccaact tcaagagact gaagaagttc ttgtttttta ttcgcttgtt cactttcaac 2208661 aacagcacgg tgtgaaagga tcacgcggtt tttatcacgg tcaagctcta caacgagcag 2208721 tgacagtgtt tttcctttat agtcagtgaa gtcttcaacg aaatgtgctt caacaagtga 2208781 tgccggaata aaaccgcgaa cgccgatatc aacgacaagg ccgcctttca cgacatcttt 2208841 cacttcagct tcaaacactt cttttgtttc aaattttttc tcaaggtctt cccaagcgcg 2208901 gtctgcatca acagcacgtt tagataaaat caaagcatcg tcttccactt ttgttacttt 2208961 caggtcaagc tcgtcgtcta ctttaacaac atccgatgct ttctctacat gaagacttga 2209021 taattcactg attggaataa taccggattg tttgacattg ataatttcta catctacatg 2209081 tttgtcttct acctttgtca caatcccttt aactacatct ccaacctctg gcacttgaac 2209141 atcaatttga ttcatttcct ctgtcatttg aataacctcc ttggtccaaa cctacacagc 2209201 ttaattaaaa cggtttgaaa gctgaacata taacatgccc gcttttagcc gaatatgtat 2209261 taaagaatca tccaaaaaag ttttttgaat gatcaataaa aagttttatt agtattaact 2209321 tctaataaaa ggacaggttt gtcaagcaat aacattctat cttcgttgaa aaattcaaaa 2209381 aaagtggcat ttgccatcct cagcgggact tttgctccac agcctcgagg attttatcag 2209441 ctacctcttg aatggaaagc gatgtcgtgt cgatttcaag agcgtcttct gctttacgca 2209501 gcggagatac ttcgcgctct gaatcaagct tgtctcttct tgcaatttcc tcaattaatg 2209561 tttcgtagtt gacatcaaag ccttttttca cattttcttc ataacggcgt ttcgctctct 2209621 cttccacaga tgccaaaaga aagattttta cttctgcatt tggcagcaca tgcgtcccga 2209681 tgtcacgacc atccatgacg acgccgcctt tttccccaag ctgctgctgg cgtttcacca 2209741 tttcttctct gacacttctg tgcttggccg caattgaaac ttggttgctg atttcatctg 2209801 ttctgatcgc ctcagttaca tcggtgccgt ttacaaacac tttttgtcca tcttttgttg 2209861 taatcagctc aatgtctgtc cgctttagca gctcagccag tttttcttca tctgtcagat 2209921 caacgttttc ctgtaaagcc gcgtacgtaa tcgcccgata catcgctcct gtatcaatat 2209981 atatgtacga ttttttctca gccacaattt tggcaacggt gcttttcccc gcagctgccg 2210041 ggccgtcgat tgcaatcgat aatttctttt ccataattcc tctccttgct cttttctcct 2210101 ctaaggattg tatcacgaac tttatgaaaa agggtgaaaa attgatgaat aattaatgtt 2210161 tgaaggtttc aatcctattg ttttcctcca ttttatccac cccttcatat tgaatcactt 2210221 ttgatacgta tggttcaata tgctgatagt gaaaaagaaa ttggacacca agtaaaatga 2210281 tggcctgaat gaacaataat ttgatcagca gccgttcaaa tgttttcatt ggagcacctc 2210341 cattacaaat agtatggaag tgtttgccga tgtttattcc attcgggcct ttcttctctt 2210401 atttaactgg cgcctgatgc agtattgaag caaagcctgc tggtcacctg ctgcaatttc 2210461 tgaatactct aaagtcattt ttcgtttttc tgacttgggg tcattaaaga ttcgtctgac 2210521 aactgcttct gtttctattt gacgtgtgtg ctcctcttca ggaagacgga tgatcaggcg 2210581 caatgattcc cccgattgaa aagaaaggcc atcagctaaa accacggcga tgccgcctgc 2210641 actgatgtta taggatagtg tgcggatctc ttcttcattt cccggctgaa tttgcacatc 2210701 taataccgca tcagttctta catattggcg gcgctggatt cttttcattt tttcacgggg 2210761 aggcatttca agacagatca tttgaagttt gtccttcact ttacctttta tacggcttat 2210821 aaagcgataa ggaacttcgt cttttcccac aaactctacc gttacttcca tatcgttatg 2210881 taaaatcaca gttcgccctg taactacatc aacaggatac gcgatcaaaa gttcattgtt 2210941 ttcgatgctg accgccttgc tttttgcctt tttcaattca ttttcttcta tatattctaa 2211001 aagtacattt tctccaatct ctatcattga cttcactctt tcgcattcaa tatactcacg 2211061 tttttattaa agcacgtaat gaaaaaaagg aaaagacatt tagtcctttc ctcctgtttt 2211121 tataggtctt tatatatagg ttctgcattt tttagttttt caaccttttc ttccgatccg 2211181 tctttggcat tgatatacat tctgaatgtg tcattttcaa ttgtcccaag catttcgtag 2211241 cataacactt cttgacctag ttcatttgta atcaaagcga gccttgtttc tctcacttgt 2211301 acatttttat ttaatttaga ctttgcctct gcttcagtaa ttgcaggctt aggtatggtt 2211361 ctttttctgt gagatgtgag gaagtctctt gctgaaaagc cgacaacctc accgtcatcc 2211421 aaggccactt tcatacgaat tgcctcgggg tacatccgga ctttattttc aacaggaaca 2211481 tatgaaaata caccgatttt atcatattgg gcactttcat caatttccaa atcatctgtt 2211541 tcaaatccgt ttttctttaa aaatgcaagc gctcggttcg atccgtcatt taaactgatt 2211601 ttctgatctt tcacttctct gttttggatc aagtataccg gatgcccgcc cttcttcgta 2211661 atatccatat aaatcactgc tttatggtct gggtctttca tgctgatgct atatacatcg 2211721 cgatttgttt tttttccgct ctttaccact ttaattgaat aattgtcatc tggggcaaag 2211781 cgctcagcaa tttgttttgc ttcctgttcg gaaatttgtt ttcccttcag atggctgaag 2211841 cctttctctt cttttttcgt actggtgaaa ctcgggccaa gatcagtgcc agtggagaat 2211901 gcaccaacat ttttttcgac tgttttaaag ctgttgataa tcgtattatc actttgtttt 2211961 tcgtcagaag ccagagccat ttctacgtcc atccagcgaa ggtttttgct catgacaagg 2212021 tgctgaacat gacgcaattc attttgtata tcttcggact gctgatatag cttatttagt 2212081 gatgtatact cgtttttatc aagcggcttt tggtccaaat ctctgactga cgttttatag 2212141 ctgaaatcgc cgatctttga taatagctct tcagttttat taaacggcat taatgtaagc 2212201 ggcagctgac tgacgctgtt atgagcttct gatgtaatcc tccacacatc gatcaatgca 2212261 ggcgacagtg atttttggct gttcatggca agtgttgttc cgattttatc atgaagctga 2212321 tccacctgat aggtaagctc atgaaacgcc cgctgatagt tattttcagc atgaagaaga 2212381 actgcgtctt tttcctggtg ttctttgtat ccccagtagc ctgtaccgac tattgcaata 2212441 ccaagcacgg cgattaaaat tcctctgatc atttatcaca cctcttttta tgctttctca 2212501 tatctgctac tcacagaaaa tgtgtttacc gattctttta atctgcggac gcccccaaat 2212561 ccacggactt gtagccgtat ccggattaaa gtagtaaagt gcttcctctg atgggtccca 2212621 gccattgatg gcatccagca ctgcttctcg tgccgtttca ttcggctgca tgtaaatttg 2212681 tccgtcggct actgctgtga aggcaagcgg ctcaaaaata acccccgcta ctgaatttgg 2212741 aaataacggg ctgttcaaac ggtttaaaat gactgctgca atagcaacct gcccctcgta 2212801 cggctcgccc cgggcttcgc cataaaccgc ttgagcaagc agcctgatat cgttgttgga 2212861 aaatccacca ggcatgttcg ctgctaccgc atcctgtttt cttgcttttg ctggtgtatt 2212921 gttttgctgt ttattcgcat tcgctttagg cttctgcgtt gttttttccg caggctgttt 2212981 ctgccgtgct tctgcttgtt gtcttgcctt ttgtgttgct gcttttgatg gtttcgtctg 2213041 atactttagc ggaatttttc cgtaatgcgt gaatgtattc cctttattga gctgttccat 2213101 gacatattca cgatagtatt ttgatttaca tattaaggtt tgctttgttt tagctcctac 2213161 aaggccgtca acctctttta acccgaattg atcctgaaaa tttcgaactg cccagtacgt 2213221 cccccatcca taaaccccgt caatttttcc gttataatat ccgttgtatt gaagacgcgc 2213281 ctgaagctcg accacatcat cccctgttgc ccctctttga atgacctgat tcgaaaaggc 2213341 agagatcgtt tcagtattaa taaacgtcgt tattgtaaag gaaaaaagga tgagacatgc 2213401 cataatcgat cctttggact tcatcttttc aagcctccta ctgcaaattt ttaagtgtaa 2213461 tcgtattttc tgtaacgagg ttatttttat acactctttc cttgttatcc ctcagaacat 2213521 aaaaactgca cacaaaaaag ccgcacggtt gctgtgcggc ttctatactt gcatcatatt 2213581 aacggaacgg gcttttttcg ctttacgcaa accaaaccac cataaaaata ccataaatgg 2213641 aagcatataa taaatccaat tgctaagcgc tgttaggata aaatcatatg atccatgcaa 2213701 aagggatggg acaactaaag aaagagtaag ccactttaca cgcgccttat cagcggaaaa 2213761 acgggctttt ccaaggtaaa atcccattat aacgccaatc aaggcatggc atgaaacagg 2213821 cagcagcgcc ctgacaaacg catgctccac gccgtggcca attaaataaa gaatattttc 2213881 gagggttgca aaaccgagtg atacacttgc accgtacaca atcccgtcat aatgctcatc 2213941 aaagtgggcg tgcgggtaaa cactgatcat cagtataaac cattttaatg attcctccaa 2214001 aaaccccgaa gataaaaaag aaacgaaaaa gcttccgcct cctacattct ctttttcaag 2214061 tacatactgg ataaacatga tgggaaatac aagaacaacc ccgagaaaaa acgaccgtag 2214121 caccatatgt acaggttcat tatcatactg atcttttaaa taaaaataac ttaataacgc 2214181 gatgccgggg gcaattcctg cagagatgat tgcaaacatc aggcaacctc tttcctttat 2214241 attcctacat ctatcctacc atgttgttta aaattttaca tctgtctgca cttaaaaaaa 2214301 caaaaagagc atacgaatgc atcatatgct cctcatcttt aatggttttc tcttttggcg 2214361 atttccgctg cgatatgccc cccgtgaaac ctgccgtttt caataaatat ttcatttgca 2214421 ttgtttcccg cagcaataac accggcaata aagacacctt caacgttcgt ttccatcgtt 2214481 tcttcgttga aaaatggacg ccctgtttct ttatcaattt caacaccaat tttttcaaga 2214541 aattgatgat cgggatgata gcctgtcatg gcaaatacaa aatcattttt aatggtaatg 2214601 agttctttct ctccggagcg aaacacaact tcattctcgg tgattttttc gacacaagct 2214661 ccaaattcca tacggattgt accgtttctg acgagagctt caaattccgg cagaatccac 2214721 ggcttaatgc tcggagaata ctcattgccc ctatataaaa ctgtgacacg cgccccagat 2214781 ttcacgagtt caagggcggc gtccacgctt gaatttttcc cgccgatgac aacaacatct 2214841 ttatcaaaat acgggtggcc ttctttaaaa taatgaaata ctttcggcaa atcctcaccg 2214901 ggtacgccca tatagtttgg atgatcataa tagcctgtgg cgatgataca atatggcgtc 2214961 gtgtaggtct cttttgacgt ctcaataacg aatgtgttat tttgcgtttt cgtcacttta 2215021 cgcaccattt caaacgcatt aacacggatg tttttccgtt taacgacttc ccggtaatac 2215081 gataaagcct gaattctgac aggcttcctg ttctctgtaa taaatgccac atctccgatt 2215141 tcgagctttt cacttgaact gaaaaaggtt tgatgcgtcg ggtaattgta aatactgtta 2215201 acgacattgc ctttttcgat gacgagggca tcaatgccaa tttgttttag gtgaatggca 2215261 gcagatagtc cacaaggtcc tccgcctata ataattgctt tttcttgaat catttctgtc 2215321 aactcctgcg attggcattt cacttcatat tttctatttc cgaataaaaa aatctcctat 2215381 tttatcatag gagatttttt atttttatgc aaatcatcaa cttatatcca gcctctaaaa 2215441 cgcgaagctt cagccatttt gcgaacgccg accatatatg cagcgagcct catgtcaatt 2215501 cttcggttgt tagccatttc gtaaatattg ttaaatgatt tgaccatcat tttttctaat 2215561 ttttcttcta cctcttcttc actccagtag aagccttggt tattctgaac ccattcaaaa 2215621 taagaaactg ttacgccacc ggcacttgcc agcacgtctg gtacaagcag aatgtcccgg 2215681 tctgaaagaa tttttgttcc ttcaagcgtt gttggtccgt tcgctgcttc aacgacaatt 2215741 ttagcccgga tattatgggc attttcttct gtaatttgat tttcaatcgc agcaggaacg 2215801 agaatatcac aatccagctc cagcagctct tggttggtaa tggtatcgtt gaaaagcttt 2215861 gttacggtac cgaagctgtc gcgtcggtcg agtaaataat cgatatcaag gccttccgga 2215921 tcataaagtc cgccatacgc atctgagatg ccgacaactt ttgcccccgc atcatgcata 2215981 aattttgcca aatagcttcc cgcgtttccg aagccttgga caacgacacg cgcaccttta 2216041 atatcgatgc ctctcttctt agccgcttct ttaatacaga tggtaacacc ttttgctgtc 2216101 gcagattctc tcccgtgaga tccgccaagc acaagcggtt tgcctgtaat aaatccaggc 2216161 gaattaaatt catcaattct tgaatactca tccatcatcc aagccatgat ttgtgagttt 2216221 gtaaatacat ccggtgccgg cacgtctttt gtcgggccga caatttggct gatcgctctg 2216281 acataccctc tgctcagacg ctccagctct ctaaacgaca tatcccttgg atcacaaaca 2216341 attccgcctt taccaccgcc atatggaaga tcaattatgc cgcattttaa actcatccaa 2216401 attgaaagcg ccttcaccgc cttcacctct ttttctgtta cgttcgggtg aaaacgtatc 2216461 ccgcctttcg ttggaccgac agagtcattg tgctgcgcac gatatcctgt gaaaatcttt 2216521 actgaaccgt cgtccatacg aacaggtatt tttaccgtta ataatctcat cggctctttt 2216581 aacaattcgt atacctcttc gggatatccc aatttttcca gagccttatg tattacggtt 2216641 tgggttgatt ttaatacatc aagtttgtcc tcttctgtat gaccggtgtt tcgatcggct 2216701 gccatttgag ttaacctcct agaatcttct gtttctcaca tgctcccttt cagagaatag 2216761 tatacacctt catatgatct gtgcatagaa taaacgttat gtttttccat gttttttaac 2216821 gaaaaaaaac tgctgaaatc agcagttttc cgttgcattc ttatgaaaaa tgagtttgta 2216881 tcgtttctac ggcattaccg tccataatga gcttaccata ctcttgcagg cgataaatcg 2216941 ttaaagttgt cggattgccg tattcagcca gaaccgccac aaccccttca gccgtatgtg 2217001 accctagatc ttcaaggctt aaaaagtact gcccgtcata gtggtagaca gttccccctg 2217061 tgataccgat tcgctgtaag ctttctgaaa gctgaatgat atcttcaaag gaatggaatt 2217121 gatatatgat gtccgcgctt tcatcaagct tgacttgcat ttcgatgtaa tcatcatcat 2217181 actcatcgtc ttctgaatcg gcgtcttggt tctttgttac aatcacgacc atcccttgtg 2217241 cttggagaga atacacttcc actgcaatcg gtccattcgc ttcaaagccg agctctgtat 2217301 ttgcttcatt catcatatct ttaaataact ggtggacttt aaatgagtcc ttccagaggt 2217361 cttcttttgt caatccccgg tctgtcaaat catcgagggt taaaaagatt ttgatcttat 2217421 tataattcag acgctcaagc cgcataacgt tccctcctgc ctctacttgc acacaaatca 2217481 tataacacat tatatgagat gatgagtcat aggttcttaa ttgttatcag tttacactga 2217541 gttcactagt aagacaagca caatgcagtt tttattgcca tacggatttt tgctttttag 2217601 aagttattct ggcccgcaaa gagtcacaat gtgagtttca ggctcagcac ctaaacgaag 2217661 aggcactttt gtcgtgccgt agccgttgct gatcagatat gccgcgtttt taacaatacc 2217721 tgttttcccc agttcataag gaccgaattt tccaaacctg atctggcctc catgggtatg 2217781 tccgctgagt atcacatcaa taccgtcatc ttcattgatt tgttcatgaa tctccggatt 2217841 atggcaaacc agaatattca gctggctttc atcaagttct ttgatggctt cctcataatg 2217901 atccatctcc atcctgatat catcaacccc cgcaatcgca atcgtatgcc cattgtatga 2217961 aaacgggact gactcatttc tcagagtgat gacgccgtgc gctttaaata tggaatacag 2218021 cttatgctgc ctgacttcat aatcattatt cccccacaca aacacgatag ggaccccgaa 2218081 atgtacgagc cttttgatgt tttcctcgat tctcgcactg ggcaccccgc cctcagctaa 2218141 atcaccgccg attataacca agtggggggc atggcttcgc gctttttcta aaaggtcttg 2218201 atcgatgaga cgtttgtgaa tgtctgaaat aaaaaagatt gtcagaggcg gcttgccctt 2218261 catctttgat aaaggaaacg tatgtgtctt caaatgattg ccttttgctg ttgcatacat 2218321 ttttgccgtc attgccgctg ccgcaacagt tagtacaccg gcaattttca ctgatagctt 2218381 cataaaaaac tctccattct ttttagaact tatcaataag acggacaata aaaaaagacg 2218441 tttctatcgt ttgagaaaac gccccatttt atttactttc aaaatataga ttaatgtcat 2218501 atttgtgctt catcatatga aaaacagact ctctcgcctt ccatttatcg ggctgcggcc 2218561 agagatcagt gcttttctga ataatttcac atctcagttt atggaaatca gtctcggatt 2218621 tttcttcctt tttcttgaaa taatatgaag tgcagtaggc aaaagcggtt gccagcatcc 2218681 aaaataaata aaaggtatgg ctaagtattt cttgaagtat aagctgaggc tccgggcttt 2218741 tgatcatgat cataacacat aataagccta ggcagataag tgaagcccat cgccatctgc 2218801 ggcattgtgc tgcataattt tcgaattttt gttttcgttt taccagcgct tggagcatct 2218861 gtttggtcgg cgcgtctgta aactgatcca gctgattcca taaggattcc atacgcttca 2218921 caccttgtcc attttcattg ctacaatata tgaacgtaaa ataaaaataa taccctattc 2218981 atccattaaa gggatgtcca aaacttgtcc ggtgtaaaca tcatttccat tcagatgatt 2219041 atatgctcga attttttctt ctcctgtccg gcttttataa tacttcatgg aaatgcggta 2219101 tagcgtttct ttcttttgga cggtgtgctt gacaacgcga ttcggcacat tttgaactgg 2219161 ctcagctggc tgttcttgct gttgtactgt tgattgggaa gaggaagcag ccgcggcggt 2219221 tgcttcctcc ttatttggcg agtcttcttt ttccgctaca gcagtctgtt tcttatcagc 2219281 agctgtttgc tcttttggct tggaatcttc tggctctttt tttgactcct tctgcagtgc 2219341 ggtttcttta gtgtctgcgg tatcgttttt atcctctgat ttcgggacaa cctcatattt 2219401 gctttggctg ctgtcaataa aaacatcttc ataatcgtca tgattatccg ggtggctctt 2219461 tagataaaat aaggtgacta aaacgataac cggcacaaat acaaatatta ctgcgagtac 2219521 tgtgaataat ggcgtttttg ttttgccttg cttttttttc tgttctcttt gattttttac 2219581 agattgtctt gtcggaaggc tttctccatc atcgacataa tcgtccgcca atgcggcgtt 2219641 ttgatcttca taaagattct gggcttttct tctctctact ctcgacatgt tcgtcatgtt 2219701 tatccctcct cacatgttca aaacgaatct gacaggcaaa cacggcatca atgataaaat 2219761 gcgccgtcat cggaacaaat aagttgccgg tccattcata catcagaccg agcaaaaagc 2219821 tgattgctgt caccataata aataacagcc attttgacaa ataccgaaag tgcagagcgg 2219881 caaatataag gctggccgtc cataaaccga tatgagtctg cagcactcct ctgaataaca 2219941 tttcttccgc gaaagcaatc agaagcgtta aaaatataat atgagggatt gacctcttac 2220001 tgaatatttt tttattgatt ccgccgtcat catataaatg agacggaaac catttcatta 2220061 ctgccatatc ggctaaaata acaataacag ctatagaaac accataccag atgattcgca 2220121 tatcgcgaat gtcccagagc tttaatacgt cccgtacatc ctcaaaaaag aacagtcctg 2220181 ctgcagcagc ggcaaagatg atgagtagct gcgtcaaata taactgcttc agcatatcat 2220241 ggtcagtcat atgctgaata taatcttttt gctgtttcag ttcagctcac ctacagtctg 2220301 caagctgaat atccggtgca attccgaact ccagctgtct aatggcgcca ttttactccg 2220361 ttcccctttt tgttcataca aggataaatc aaaaccgcaa tgtgaacagc acgggaggtt 2220421 tccgtcatca ggctcgtatg attcatcaaa gtaggttaac agtgcctgcc ttaaacagcc 2220481 gtcacgctga agcaaaaatg atacacggtg cattttttcc agcttcagct ccatgcgata 2220541 tgaaatttct ttcttcatca gttcaactga tgtttttccc tgcataaaga gatgaatcat 2220601 catacgggcc tgtgtctctc cgacgccata ctgaagtaat acgtcacgca gccttctctc 2220661 atcccgctcc tccgtcttct ctagcacacg gattacgtcg gcgatttctt cagctgtgac 2220721 actctccatc tggataattt gttcctgcaa ttcaaaatcc cctggcgccc gcagcaaaat 2220781 gctgacactc ggctttccgt cgcgtcccgc tctgccgatt tcctgcataa aagcttctgc 2220841 cgtctgcggg agatgaaaat gaatcacata tctgatatca ggtttatcga cacccattcc 2220901 aaacgcattc gtacaacata tcacatcaag ctggttatga ataaactgct gctgaattaa 2220961 aatcctgtcc cctgactcca aaccgccatg gtaaaagtcg gctctgctgc tcgttttgct 2221021 tttaatttca cccgctaatt ccttagccca tttccgtgtt ggacaataaa caattcccgg 2221081 accttgcagg ttttcaacca gctgaatgac cctatctatt ttttcggcag tatccgccgc 2221141 attttcaacc ctcagtgcga tgtttgggcg gttgactgag ttgagatggc gtacagcatg 2221201 ctgcagctcc agcaggttca tgacatcttg cagcgtttcc tttgtagccg tggcggtcaa 2221261 tgccagaacg ggtgggtgtc caagtttttt tctcagctgt ccgagctttg aataatcagg 2221321 cctgaagtcg tgtccccatt cagaaataca atgcgcttcg tcaataacaa ataggctaat 2221381 cggaacgctt ttcaattttt ccaatacata tggagactgt aaagcttcag gagacaagta 2221441 caaaaattta tatcgatgaa tatgttctaa aacaaattgt ctttcctgcc tgttaagcat 2221501 gctgttcaaa gctgcagcac gcttttcccc ccgggctttg agctgctgca cctgatcctc 2221561 cattaaagaa agcagtggag aaacgattaa taccatgcca tcaagcatat aaccaggcag 2221621 ctggtagcaa agcgatttcc ctcccccagt cgggagcatt gcaatggtat ccttcccgct 2221681 gagtatgctt tcaataatgt cctgctgccc ttttttaaag gaagtaaaac caaaaaactg 2221741 atataacgtt tgctgtaatt tagtcatatt gctgcacctg ctttgtcaat gccagtctga 2221801 tttgaaagta gctgaaccgc tgttccagcc cgtcgcgaat ttgtttgatt ttattcgtcc 2221861 gcatccgttt ggcaaactct gcgatttgaa gctggtcttc tgctgataca tagtcattaa 2221921 tcataaacgc aggctcatgg agagaaatct cgacaatgtg gtcttcaatc gtcgctgttt 2221981 tcagctttct gatttcagca attcgctgta tcggaaaccc ttgtttgacc atctgccatg 2222041 ttttcctcgt cgactctgtc agggcattat ctaagtgcac atcagaaagg agatccttta 2222101 acaaagcatc ttcacactcc ggaagagaat gaataaaata atgtaccgaa gcccaaaaca 2222161 tgatatagac ataccattcg tcttctttca gcgtatcagc aagctgcctg ctcgtataac 2222221 cgatccgatg gtgcgaggtt aaggagtaga caaaaatttg cgctgctttg ttttcaatct 2222281 ttttcaaatg cgcctcaagc atggcaaaaa ggctttttgc catctctata tgatccgtat 2222341 gccgggacag gtatttcttt acccagtgaa gtgtcttatg atcctttgtg acagggatat 2222401 actgcctgct cccttgctgt ttatgggata ggacctgcac aagcagcgaa agccttttcc 2222461 aaagcacgcc ggcagcctgc tgataatgag cgccgtgaca atgaacgggc caaggccgct 2222521 cgctaagggc atgtctcaaa actgctgcgc cgctggctgt cactttgtat gtatctgatt 2222581 cagacattgg cgcgagatat gaatgctttt caagcttgtc aagcgacgca gaaatatcgc 2222641 ttctcgaaca ttttgccgcc attccaaagt attttgcagt ctgaaataag ccggcatctt 2222701 gaatggtctg tgacgatctc ttgcctttga ataggtgaaa aacagcgctt cccgaccgtt 2222761 ccccgtttat tttgcaaaga caatcgagaa ccataatatc gaagtaattt aatgacaacc 2222821 tatccaccta cattcttcct gacaaaaatc gttgatttgc tctttttatt ttaacagatt 2222881 tcaaacagaa atcgacgttt aaagtcatca ttaaggggga tgttatgtag ataacccctt 2222941 atgtgataag cattctcaat catttttctg ttgaaatgtg gcagcaacat cattacaata 2223001 agtaagagga ataggtgtta aattgattaa atataaagat tgatccattt gttccaccaa 2223061 gaacaatctg ggaggtttta ttcatggcaa agtacacaat cgtagacaaa gatacatgta 2223121 ttgcatgcgg cgcttgcgga gctgctgcac cagacattta cgattacgat gatgaaggca 2223181 tcgcgttcgt aacgcttgat gaaaacaaag gtgttgtcga agttcctgag gtactggaag 2223241 aagatatgat tgacgcattt gaaggatgcc ctactgattc catcaaagtg gcggatgagc 2223301 catttgaagg cgacccgctt aaatttgaat agaagtaact aaaaaaagct cccgaacggg 2223361 agctttttta tttaatggat atgtgcactt cgctgctgct caatccatgg cttaagcttg 2223421 ataaaaatta gtgagaatac aaccgtaatt acaatacctt ttatcatgtt aaacggcagg 2223481 atacctgcga cgactgctgt ttttagcgcg ctgtcggata atgccggtga atgtaaaaac 2223541 cacgtgtatg ccggaagaat cagaacataa tttaaaatac tcattaaaat ggtcatcgct 2223601 gcagttccca aaagcaggct gacagccaag ccctttgctg agttgagttt tttaaataag 2223661 aaagcagtcg gtaatataaa gagtgttcct gcaataaaat tcgcaacttg ccctacagga 2223721 actccggcca tgcttccctg aatgatatac tgaagaacat tttttatcgc ttctacggca 2223781 atacccgcca aaggtccgta aatcagaatg gcaataattg cgggaacgtc gctaaaatcg 2223841 atttttaaat aatccggaag acccggaaac gggaaattta acagcatcaa aacaaatgca 2223901 atgctgctca gcatgctgac cacaactaat ttttttactt tcacttcatt ctctcctttt 2223961 cgatcacatc ttactcgaaa acggaaaggt tcttttccag ccaataaaaa aaccgcttca 2224021 tatataaaag cggggtttcg aaaattaggc taggcaaaga aacgtttgaa aaattcaatt 2224081 tcaaaacgct tatgaacctc catcttctcc catccagact gtactgtcgg ctccggaatc 2224141 tcaccgaatc ctgctgtaaa gacagctcgc gggcttagag ccattggctc atcaccgccg 2224201 gtagggaatt tcaccctgcc ccgaagattg atcatatgaa atttaattac attataaacg 2224261 ataactggtt ggctgtatag agaattgctt caaattaaat atattacctg caagctgtca 2224321 gatcattgat ttattaggct ttacttttat cctttactgc gtcaatacac gttgacactc 2224381 ttttgagaat atgttaaatt atcagatatt tagtttgtca atttaggagg aaatctaacg 2224441 atgtttcgag tattggtctc agacaaaatg agcaacgacg gtttacagcc acttattgaa 2224501 tcagacttta ttgaaatcgt tcaaaaaaac gtagcagatg cagaagatga attacatact 2224561 tttgatgctc ttttggtgcg aagcgcgaca aaagtaacag aagacctttt caacaaaatg 2224621 acttctttaa aaattgtcgg aagagccggt gtcggtgtcg ataatatcga tattgatgag 2224681 gctacgaaac acggggtaat cgtgatcaat gctccgaacg gcaacaccat ttcgacagct 2224741 gagcatacat ttgcaatgat ctcttcttta atgagacaca ttccgcaggc taatatctca 2224801 gtgaaatcca gagagtggaa ccgcacagct tatgtcggtt cagagcttta tggaaaaacg 2224861 cttggtattg taggattagg ccgaatcgga agtgaaattg cacagcgtgc gagagcgttc 2224921 ggtatgactg tgcacgtttt tgatcctttc ttaacggaag aaagagcgaa aaaaatcggc 2224981 gtaaacagcc gtacatttga agaagtgctt gaaagtgcgg atatcattac cgttcacacg 2225041 cctttaacaa aagaaacaaa aggcttattg aataaagaaa cgattgcaaa aacgaaaaaa 2225101 ggcgttcgct taattaactg tgcgcgaggc ggaattatcg atgaagcagc acttctcgaa 2225161 gctttggaaa acgggcatgt tgcgggagca gcgcttgacg ttttcgaagt cgaaccgcca 2225221 gttgacaaca aacttgttga tcatccatta gtcattgcca ctcctcactt gggagcatca 2225281 acgaaagaag cacagctcaa tgtcgccgcc caagtgtcag aagaagttct gcagttcgca 2225341 aaaggcctgc ctgtcatgtc agctatcaac ctgcctgcca tgacaaaaga tgaatttgct 2225401 aaaattaagc cttaccatca aattgcagga aaaattggca gccttgtatc acagtgcatg 2225461 aaagaaccag tacaggatgt tgccattcaa tatgaaggca caattgctaa acttgaaaca 2225521 tcgttcatta caaaagccct tctgtcaggc tttttaaaac cgcgcgtaga ctctactgtt 2225581 aatgaggtca atgccggggg tgtcgcaaaa gaacgcggca ttagcttcag tgaaaaaatt 2225641 tcctcttctg aatctggata cgataactgc atcagcgtaa aagtgacagg agaccgcagc 2225701 acctttactg taacggctac gtatattcct catttcggag aacgaattgt cgagatcaat 2225761 ggatttaata ttgattttta tccgactggt cacttggtgt atatccagca tcaagataca 2225821 acaggtgtca tcggccgagt aggacgtatt ctcggagata atgatattaa cattgcaact 2225881 atgcaggttg gccgtaagga aaaaggcgga gaagccatca tgatgctttc ctttgacaga 2225941 catctggaag ataaaattgt gaaagaacta acaaatgtcc ctgatattgt gtctgtgaag 2226001 ctcattgatc tgccataatt aaaaaaactc aagctatata gcttgagttt ttttattgtt 2226061 ctatccccgt gtgtttttat gcaaaatatc taagacactc cttagctcag aaacaggaat 2226121 ttggcctggt gcggacgcct cttctccagc tccaaaagta caagccgatc caaaaacctc 2226181 accgctcagc ctgctgatga gccctgttgc agccattgac attgtaataa tggggcggtc 2226241 tgcatatatt gttttcattg tatacgtcgc atcaagcagt gttaggagat ctccagtatc 2226301 attcggcatg acagccattt ttggaatatg cgcgcctaag tcctgcattt ttcgaagtct 2226361 ggaaataatt tcatctttta caggtgtttt ttcaaagtcg tgatttgaca tcaccacata 2226421 gacgttgttt tcttccgcca gcgatactaa cgcttttaca tttgcatctc ctgaaaataa 2226481 ttcgatgtct atcagatcga tgtcttttgt ttggattgcc gattccagca aagcaagata 2226541 ggagctttcg tccatctcca tgctcccgcc ctctttgtgg gttctgaatg taaatagaaa 2226601 tagcttgtct tctaaagatt tacgaagctt agaaatgagc tttgtgaccg cttctctgtc 2226661 attcgctttt tcaaatacgt cgactctcca ttcaacaatg tccggattca gtaattttac 2226721 tgcctctgct tcattcagaa tttgtttttc cgtctttccc atcagcggaa tgatgatttt 2226781 cggcatccct tccccgatgg aaactccttt aatcgttaac acgttcactc gtctcaaatc 2226841 ctttcaatct ttaccttgtt ttattataca cgtacaactt ttttttgaaa atttctatta 2226901 tatgaatagc aactaaaaaa gagccttaaa gggctctttt tagtttaagg aaatcggatt 2226961 tggagcagct ggcaccggaa ttgcatctga tatgtcatat ttgccgattt ttttcgttct 2227021 ggtttccgta aaggtcactt ctgtgaagcc aaactctttt gcagtcaaaa gtagtccctc 2227081 aatcattaaa ataccggcaa tagaatcatc aacttctgac tcctttgaaa agcggatata 2227141 taagtgtttc tgtttcttcg ttacagattg gacagcaccc gcttgaataa gaggtgtcgt 2227201 atcttcttgg ctgctcgatt ccatttcctt aatcgcttct tttactgtat caaaagaatg 2227261 atttgacgga acgagaaagt cttgtccttg tttattttgg tacaagtagt aggatcgttt 2227321 tgactgtttg ggaatcgaaa tttccgtaaa agtgccatat gagccaatcc gaaccccagt 2227381 ctcattttga tccgataaaa atttgacttt ttcataagga ctccatttta aggattcttt 2227441 aagcaatttt tttaacagtg tatcatcttt tatagaaaat gccgtagctg gctgatggac 2227501 tcgtatactt aattccttct gctttggttt ttcctttatt tctacttcat ctatgaaggt 2227561 tggaattgta atggcatgat caaggatgcc caattcacta ctttcaaaca gcatatcctg 2227621 gatcgtttgg tctgcatttg ttttttgaat gctgacgggt atgattgcag atgtatcggc 2227681 atcagcaacc gctacagtga tgtaattgtc ttgttccttt tcaggaacga caaacgatgt 2227741 ctgatccaag gacgatgcag cttttgggct gtcttctgtc tcagttttcg ttactgcgtt 2227801 ctcttgggac gcttcttttt gttgaggctg tgcctgatca aagaaatgag gagaaataat 2227861 gaaggcgata taaaccgcaa ttgcagcggc acacgcgggg ccaatccacc tgacagcggg 2227921 cttattttta cgctttgcca tcgtcagccg cttgtaaata tcctgaggcg aacgatggtc 2227981 tttaactgcc ggaagttgac ttaacaactc ctttatctgt tcttcgttcc attctgactt 2228041 catcatccat tagctcctcc ctcaaaagct ccatatgttt ccgaagtact ttgagccctc 2228101 tgtgttgggt cgtttttact ttgctttccg agaagcgcag agccttggct gtttcctgta 2228161 ttgaatatcc ctgaataaac cgcaagataa tcacagctct ttgatcgatt gtacattgat 2228221 caagcgcagc ataaatttcc cggacatttt catgttgaac cgcaagttcg tccggcagca 2228281 attgctgatc cctgacatcc tgtgtatccc agtcaaatgt accgagtata cgctgtctga 2228341 ttgtttgctg tttacggaac cagtctatcg caacatggcg tgcgatagac aaaagccatg 2228401 ttttttcact gcttcttcct tcaaacgtat gataagaatt taatacccgg atataaacct 2228461 cttgaagaag gtcttctgtc tggtttttat cctttaccat ataaaataaa aattggtaca 2228521 aatcttgatg atatgtatca tataataatt gaaaggtttc ttccatttga aacccctccg 2228581 ttcacttttt tgtcgtatga atagcttgaa aagttacatt acaactatat tacgagtaac 2228641 tggaatttgg aagggaattt atattaacat atccttaaat tttattaatg ttggctatta 2228701 aaaaaacacc cgctcagtca gcgggtgttt cttatggaac aagattcttc ggcaaattca 2228761 gactcgattt taccgttttg tcggaatata aaaagaaaat gttgttcctt tatctattcg 2228821 gctgtgcaca gtaattgatc cgttgtgggc ttccacgata tttttaacga tagccagccc 2228881 taacccggtt cctgctctgc cccttgtccg cgctttatct gccttataaa accgctcaaa 2228941 gataaatggc agatcttctt ccggtatgcc agacccggag tctttgatat caattttcaa 2229001 tccatccttc acagaatgga ctgaaatgga gacactgccg ccggctgaag tatgccgcag 2229061 cgcgttatca atcaaattgg taaatacctg ctccatcttg tcttcatcaa acataaattc 2229121 ctcttctgtg agagaaatgt catgatctaa agcaatattt ttttctttcg caacaccgga 2229181 aaacttccga atgatctttt ctaaaaactc attcacattg attttttcat aatgtaagcc 2229241 tgtatggcct gattccattc gggctaaatc aagcaaatca ttaactaaac ggcccattcg 2229301 gagcgattcg tcataaatga tttgggcaat ttctttccgg tcttcttcag agcttgcaat 2229361 gtcatcgaca attgcttcac tgtatccctg aagcatggag atcggtgttc tcagctcatg 2229421 actgacattt gcgataaagt cctcccgcag cttatcaagg cggcgttctt ctgtcatgtc 2229481 acgcagtacg gcaaccgctc ctctgacgtg cgattccgca taaagcggcg acatcaaaag 2229541 cacccatgat ctgccttgaa gcgtcatctc aatcatttgt tctttttcag tgctgacagc 2229601 gttttgaaac agctcttttg cttcaggcgg aagattgtcg ccttctttga tattcatgtt 2229661 ctgttcataa taccaagcct gaagaaaacg ttcagccggc gggttggtca caagaatcgt 2229721 accgtcaata ttaatggtaa taaccccgtc agccatactg ctcaaaatgt tagaaagctg 2229781 ctctttttct tgattgagcg cattgatatg aaagttaagc tgccggccca tttgattaaa 2229841 agcggtcgcc agttcaccga tttcatcctg agttaaaatc gggatttttg tatcgaactt 2229901 gcccttcgcc aaatcctgcg cgccttctct catttttcgg agagggtacg tgaccctgct 2229961 tgataaaaag aatgcgaaaa atgtggtcag cacaatcgca attccagcgg caagaaaaat 2230021 atagcgggtc gtatgttttg ttgtatcttt aacggcaagc aaagactggg ataaaaagac 2230081 catgcctttc tttccgtctt tttcatacgg gacacctaca atcaggcgtt cattatccgt 2230141 gtctgtatcg ctcagtcccg tccgtttgct tactttttta tggtctttga gagctttatt 2230201 taagtctttg tcatgctgta tttgctcaac cgtaatagac gacaggcgat ttttatcatt 2230261 cggagaatac cagtggttct tctcatcctg gatgatggca atgcttgtta agttatcagc 2230321 gagttcccaa gtgattgacc ttgccagtgc ctggtcctcg tgattttcta ggatgacagc 2230381 aactttattc gcaagctgtg ttaaatcatt ctcagcttct tccacatggt agttttcaat 2230441 aaactccagc aaaagaaccg ttaaaatgaa caatacgatc aagacgagtg aaaggatcgt 2230501 aaaccacagc ttgcctacta cgcttttcca aaatttcatt cagcgccgac ctcaaattta 2230561 taacctacac cccatacggt gacaattttt ttcgcagctt ccggagatac cttgttcagc 2230621 ttctctctca agcgtttgac gtgagtgtcc actgtccgta aatcaccaaa aaactcatat 2230681 tgccacactt ctttcagaag cttttcccga tcatacacct tgtcaggcgt tttcgctaag 2230741 aaatatagaa gctcatactc ttttggcgtc aggctcactt ctgttccatc agctgttacg 2230801 cggtgagcat catggtctat tgacagatgt gaaaacacga gcacattttt cgtcggtgta 2230861 ttggcattga aataagaggt ttgggatgct cttctcaaaa gggcctttac acgcagcacg 2230921 acttctctcg ggctgaacgg cttaacaata taatcatctg ttcccgcttc aaacccctgc 2230981 acccggtttg cttcttctcc ttttgcggtc agcataataa tgggtgtcgc ttttttttca 2231041 cgaatttgcc ggcacacttc aattccatca gtccccggca tcatcagatc aagcaaaatt 2231101 aagtcataat tggcttcaag ccctttggca atggcttcat caccattttc agcttcatct 2231161 atagcataat tttcacgttc aagatacatt cttaaaaggc ggcgaattct ggcttcgtca 2231221 tcaactacta atatttttgt ttcgttcgtt tggtccatgt tttccccctg ctttccttct 2231281 gttactttca ttttatcaaa tcgtgagaaa gtttgagaac tgtgtcgctt tcaaaggact 2231341 atgcataaga atgaagtccg gcaagcacaa gatttacgaa tattaaatta aacataataa 2231401 tagcaaaacc gattacggcc agccatgctg acttctcacc gtgccagcct cttgacagtc 2231461 ttaaatgcaa gtaagcggca tagaacaaaa atgtgatcag cgcccatact tccttagggt 2231521 cccagcccca aaatctggtc cacgcgagct gagcccaaat cattgcaaag atcagcgcgc 2231581 cgagtgtaaa gatcggaaat ccgattgata cggccctgta cccaacctca tccaccagat 2231641 caagattgac gtttttcacc agcggatgta atagagcgct gattcttttt ctgatgatca 2231701 gacggagagc cccatacaac acaagacctg ctccaaatga ccaaatgaca gtgttcactt 2231761 ttctgcctga gaaaagcgcg ggaagatcaa caagcggttc cattcttcct tcggtcaaaa 2231821 gctctccctg atgcggaccg acaagcgcgg gcatttcgta caccatcacg cttttttctt 2231881 tacttttgtc cacccagtta aactccgctt catagcctgc aagacgaaat gccgatgtga 2231941 ttgcaataaa ggcgacggtt gtgaccagga taaacataat cgcttcaagc cagaaggtct 2232001 ttttgcttgg ctttgtctgg tctacatgct tcaaaagaaa gatgacacca gcgacaaagc 2232061 tgatggcaag tatagcttgc ccaagcgcgg ccgttgttac gtgaatatac agccagttac 2232121 tttggagcga aggaattaaa ggcgagatat ctgtcggaaa catgctggcg taggcaatca 2232181 gcaataaagc aattgacagc gtaaacaggc ctaatgaagg caatctatag agaaaataaa 2232241 gaatgataaa cgccaaaaca agcatcatgc caaaagcggt ggtgaattca aacatattgc 2232301 tgacaggcgc atggccgctt gcagcccacc ttgtgatgaa atatcctagg tggcagaaaa 2232361 aaccgacaat agaaagggtg attccaatgt tggcccatcg gtttggcctg ccctttttat 2232421 ctttattccc gcgtatggcc ccgccgaaga ttgggacagc gattaaatac acaagaaagg 2232481 ccgcataaag aaaatttccg ctcagctctg ccatgacatc actccctttt cgcctatttc 2232541 tgtgttttga ttaattcttt ttggtccacc ggttcagtca gtccggaatc agccaatata 2232601 aatgctaaat ccttcttcag gccaaaccag tttttattgg tatgccctgc taccataact 2232661 gcaccgtcct gtgagtgcag ccaaattctt cgatgctgcc agtacatacc ttgaatgaca 2232721 ccgatcataa aaatggctcc gccgacagca agcacccaga gtgtcagatc ctttctgact 2232781 gtaagtccag taatgttttt cgtttcgaca tggtcaaatt tcagcttgta tttattattg 2232841 cctgatcctt cgatggtttc ttggatggcg acaaagctct tttcgccttt cggtttgtcc 2232901 ggcgttatga tattaaagac aaaagccgga ttgttaggga tctttgtttt tgtgctcggc 2232961 tctccgtcct gattaaaata gaagtcaggc aggtagctgg cgatttccac cttgtaaccg 2233021 ttaccaagat catagactga atctggatcc agaaggttga tcttcaggct cccaaaggat 2233081 ttttttgttt ttttatcaat cagctggaac accatttggt caagctgatt ctctttgtaa 2233141 tccacctggt aaacggaaaa agaatcaaaa cgcagcggct gattgacacg gatgtcttct 2233201 tctgttactt tttccagctt cggcttctcg ccataaacaa tttttccttc tctcttgtag 2233261 agtacggcat cagtttgaaa gttctttgcc actctaccgt ccccgactct gtcaatggca 2233321 tctgcaaata cctttttttc cgttttgctg ttataggtct ctacgctgaa ttgattgttt 2233381 ttcaaataat attttccgtc tgtacccgga attgctgcgg tttcgccttc tctgacccaa 2233441 agcgtctcat cgacgtacat gccaggcaca aatctcagca tcgcaccaat cagaaagatg 2233501 atcaatccaa tgtggttgac atacgggccc cagcgggaaa agcgtccttt ttcagcaaga 2233561 atgctgccct ctttttctct gattctataa tgttttttct ttaatagagt aactatcttt 2233621 tctttcgatt ccccgttcag tacagtaact gtttcactga acaagcgctg ccttcttaaa 2233681 aaggccgggc tccttctgac accttggttt tttaacgctc tatacaacgg aatgacccga 2233741 tcaaggctgc aaatcacgag tgaaatgccg atcgaggcaa tgagcagcaa ataccaccaa 2233801 gaaccatata aatgatgaaa cccgagcaaa taataaagct ggccaaacgt gccgtactgc 2233861 tccttgtaat aagtatcagc ctgtgcgccc ggaggcagat aggcttcctg gggaaaaatg 2233921 gtgccgaacg ctgatgcggc aagggttatg acgataagcc atattcccac cttaaccgag 2233981 gaaaagaaat tccaaatttt gtcgatgatc gttttgttat aggtttgcga acgtcttgcg 2234041 cttccgtcat atctcatatc agcgagcgga ggttgagttt cctgaagagc tcttccgcac 2234101 gattcgcata aaacggttcc gaccgggttt atatgtccgc attcacattt gacttgcttc 2234161 atcccgaagt ctctccgggt tttatgagat tcatataatc gtgtatcatg ctttctgtca 2234221 tagtgccggt caccaccttg acaacttttc cttccggatt gatcaaaaag gttgtcggaa 2234281 gcggagatac gtcataggca tcaagcactt ggcgatctgt atccagaaca accgggaaat 2234341 tgactccgta ggatttcata aaattatgta ctgctatctt tgactcccca acatttacag 2234401 cgacaatttc aacaccttgg cttttaaaat gcttatattg gtttgccata taaggaaact 2234461 cttttttgca cggttcacac catgtacccc agaaattcaa aaaaacacct ttccctttta 2234521 agtcactgag ctcgatacgt ttcccattcg tatcctctag gacaaaattc ggtgcgtcgg 2234581 acccttcgga tatactctct ttgccggcaa atacagcgtt gtaaatggta tagccgagtg 2234641 cgcagattaa aacgagaagg atgccggtcc gaatgaataa acgccttttt ttcttcattg 2234701 tccactgccc ccttccccct attgcagatc cattcaatta tatcattgca cgttcatttc 2234761 acatttctta ctttttgaag gttatgtgaa atttagaaag cgtttttacc gtgatccgcc 2234821 agtgctctga gcctttttac ttcgtgaggc gtaagctctc tggcatcgcc cgtgtgcagg 2234881 cctcgcaggt ttaaaaacgc gtattcctca cgcttcagct tgattacctc atgtccgatc 2234941 gcttcaaaca tgcggcgcac ttgtctgttg cgtccctcat ggatcgtcag ctgaataatg 2235001 cttgtctgct ttttcttatc caaagacagc agcttcgctt tagcaggcgc tgttttgcct 2235061 tcctccagcc taattccgcg ctccagcttt ctgagcagct ctttaggcgg gattcctttc 2235121 accttcgcca cgtatgtttt gtctatttca tacttaggat gcattagctt attggcgaat 2235181 tcgccgtcat tggttaaaag caaaagaccg ctcgtatcat agtccagacg cccaatcgga 2235241 taaatgcgct gcggaatatt tttaaaaaag tccgtcacca ctttgcgtcc tttatcatct 2235301 tgcgctgcgg aaataacgcc tcttggttta tataagagaa agtaaaccgg ctcttcgcgt 2235361 tcaaccttta acccgtttac ctcaatctga tcagaaccgg tgaccttaac acctagctct 2235421 gttactactt tgccattcac ctttactttt ccttctttaa tcagctcttc tgcctttctg 2235481 cgcgacgcaa ctccggcatg agcaatcact ttttgcagtc tttccatgtc tttcacctca 2235541 agtattatct tacttttttc aaccttaaca aacaagcttt ttcaaattcc tatgccaaat 2235601 ctaaaaaaaa cgccgttttc aggcgctccc aaataataac gtaacgatga tgatagatgc 2235661 aactacgccg attaaatctg caagaagtcc cacctttaat gcatcaccca tttttttaat 2235721 gccgactgct ccgaaataca cagtcagtac gtaaagcgtt gtatctgtag atccctgcat 2235781 gacggaagcc agcctgccga taaaggaatc gggcccgtat actgcaatta aatcggtcgt 2235841 cattccaagt gcggccgtac cggagatcgg gcggatcaga gcaagcggca ctacttcagc 2235901 agggatgccg atagcggaga aagccggttt taaaagatcc attataaaat caagcgcgcc 2235961 tgatgatctg aaaacagtta tagcgacaag cattccgact aaatagggga taatggaaaa 2236021 ggcaatttct atcccctctt tcccgccttc gacaaacgat tcatatgtcg gaaccttttt 2236081 gatcgttcca taaagaagaa ttccggcaat aatgattgga atcatggcta aagacagcca 2236141 gttgatgatt tccatccgct caccttccct tctttttgcg gcggtaataa aaataccgat 2236201 caatgataat ggcaccgatt ccggaaataa gcgttgccaa aatgcttggc ccgacgatat 2236261 ctgtcggcgt tttggaggaa taagccattc ggacagcgat caccgttgtc gggatgagtg 2236321 tgatgcagga cgtattaaca gctaaaaaag taatcatcga ccggcttgct tccgatcggt 2236381 ttccgttcag ctttttcatt tgttccattg ctttaatgcc aagcggagtt gctgcatttc 2236441 cgaggccgaa gaaattcgcc ataagattag ataaaatata gcccatcgcc gggtgatccg 2236501 gcggtatatc agggaacagt ttagatataa aaggtctgca catccggctg aaaatatcca 2236561 aaagccctga ctgctcggcg attttcatta agccaagcca gaaaacaagc acgctcatca 2236621 atccaaatga gatcgtaatc gcttctttcg cacccttaaa cacggcttca tttacatctt 2236681 gcagagttcc gttgcacatc gcaaaaacga gtccgatcac ggttaaactg acccaaatta 2236741 tattgaccat tttgctccgc ctgccgcatt cagaaagatt gatttaaacg tttcaaaaaa 2236801 ttgtttcttc ggtttttgat gccgctcatt ttcataatag atcggcactt ttgcgatggt 2236861 tgcatcgttg aacatgatct ccatgtgccc tacgatgtca gggattttcg aggcatcttt 2236921 ttcccatgct tttttcggct tgagcagtgt ggtattaatt tttacatttt ctttttcctc 2236981 ttcggtcagc aaataggtga tatcacgttt gataaaagcc ttcgattcat aaaatgtgcc 2237041 tttcagcttt ggaatatccc ctttttttgc aattaaatag gtttgataat gctcaaacac 2237101 atagttaaac atcttcatat ggtcatccca atcattaggg tcattaatgg tgacggctat 2237161 caggtcaatg ccgtcctttg aagccgtaga gaccagtgtc cgttttgcaa gttttgtata 2237221 gcctgttttt cctcctgtgc tgtacggata aagcatggtc agcagtttgt ttttgttttt 2237281 ccatacgctt tccatcgttt ccgctttgta tatttttgtg cctgaaatct tttgatagtc 2237341 tttcagcttc atagcatact tagttaaaat ggccatgtca taggctgttg aataatgatt 2237401 ttcatggtcg tccaatccgt gcgggttttg aaaacgggtg tttttcatac caagctgctc 2237461 ggctttttga ttcatcatat aaacaaaccc atcgaggctc ccaccgacat gctcagcaat 2237521 cgcgacagcg gcatcgtttc ctgatcttag catcaggcca tacacaagat ctttcagctt 2237581 cactttttga ccttctgtta aataaatggc ggagccttct gttctgacag catttgccga 2237641 aaccgtcact gtttgatcca ttttgccgga ttcgatggcg aggacggcgg tcataatttt 2237701 tgtgatgctc gcgatccgcc ttttttgatg ctcatccttg gcatataaca ctctgcctga 2237761 cgcaccgtca ataatgatcg cgctttttgc actgacatct atagcagcat gtgctgtatt 2237821 cacatttacg gttgcaataa gaaaagaaat catgatcacg aatactgctt ttttgaaaat 2237881 gcgcatgttt gctcacgtcc ttgtggtggt ttgtacaagt ttatgcgcat gtccatcagt 2237941 tatgaataac aattatattt ctggaagcaa acataaaaaa actctccctg aaaaagggag 2238001 agtaaacgtt atctgattgg cgccatgctt gatccggacg cttcgtaatg agccagctct 2238061 tccctcatct tcagaaaggc cgcgctcaac ggcaataata attgctcaag cgacgcagga 2238121 acagcatgat aaaactcaat tgcgctgacc ccggtataag acgcccggct attttcacac 2238181 cacgtgtctt ttttcggcat aaagaactct tcaatgcatt ggtgatacac attataaagt 2238241 gttttttccg ctctggcttc ctgaaaaggc tcctgcatca ggagacgacg gcacgcttct 2238301 gcgcctcctt cacaaaatac tgccattctt ctcagagtgc taagcacatc acagcagtat 2238361 cctttttcaa taggcaattc agcctgtaag gactcaagcg tcgtttgatt taggtaatcg 2238421 ttcacggtat tgacaaccat tgataagaat tcgcctgttt tttgagtctg cgctcgcaca 2238481 atcgaatgtc ccatttcgtt tggtatcttc ccctcatgta tttgtctctc acattttgct 2238541 tctttcatga tagcttcttc cttatatctt atgatgatga aaaagcgcga ttcattaaac 2238601 ttctatttta tatcttcgaa ggtttggtta aagttttcaa aaaataaatc tgcttcttct 2238661 tgaagaacgt cttcttccgc attttcaggc agcggcggaa gctcgtccag cgttttcaga 2238721 ccgaattgtt caagaaaagt cggcgtagta ccgtataaaa tggcccgccc cggaccatcg 2238781 gcacgcccta cttcacacaa tagcgccttc gcgacaagac tgtgtaaaat ccgctctgat 2238841 tttactcctc tgatttcttc aatttctgct ctcgtaattg gctgtttgta tgaaacaatg 2238901 gccagtactt ctaaagatgc ttgagaaagg ccctttgacg gcacttcaat cagttttttc 2238961 aagtaaggcg caaagtcttt tttggtagag agcatgtacg tatctgcata ctcaataagt 2239021 tcaatccctc gtgtatctcc gcggtattcg tccgccacat ccgccatgat cgtgttcagt 2239081 tcaggctctt cgatttcaag cactgttaac agctgctttt ttgtaagccc ttcatcgcct 2239141 gccgcataaa gaagggcttc cacaatagct ttccaattca cgatatcaag ccccatgaat 2239201 ggattcactc cccgtaatgt aaatatctga aaaattgtgc tcctgttcaa tgaggaccag 2239261 ctgatttttc atcagctcaa gaacagctag aaaggtcact actaaatgtt ctttttgctc 2239321 atatggaaac agatccataa agttaattct cgttcctcta gatttcaagc tgtgcacgat 2239381 ttcgttcatt ctggcttcga ttggtatgtc ctgtcttgta attgttgttt ccatcggcct 2239441 gtttattttt ttgcgtttca gcactttttg aaaagctccg atcatatcat agaccgtgac 2239501 agagagcttt tgctcagact gttttacttc ttttgcatat tcactcaaat cactcggcgg 2239561 tttcgtgaac gatttttgtc tttcttcttc ccgttctttt aaatccttcg ccgcatcttt 2239621 atattttcgg tactcaatca gcttttcaat cagttcctcc cgcggatctt cttcttcaag 2239681 taattcatct tcaaaaagct cctcctcttg cttcgggagc agcattctgc ttttaatgct 2239741 gagcagcgtg gcagccataa ccaaatactc gctggcaatg tcgagctcaa gcacgcgcat 2239801 cgtatgtaca tataataaat attgttcagt gatcttcgcc acaggtatat catatatgtc 2239861 aatttcaaga cgattgatta aatgaagcag caggtccaat gggccctcaa acgtatcaat 2239921 tttcacttga tattcttcca tcatctcacc attttcaagt atcactctca ttgccggaaa 2239981 aactggctac cctatagtat aagccaccaa aaagctctcg tccaatacta tttcatatcc 2240041 tgttttgaag gagtttgtac agaatattca aaacacaaga ggtgtttgct cggagcgcag 2240101 aagcgggaga aaaagccttt gcttctggtt ttcctttcta agaagcacta gaggccgggc 2240161 gttctttttt ccttttatcc cttctatggt acactaaaag cacattaaag gaggaagcac 2240221 cttgtatccg aaagcttata tagattatct cgttgagttt catgcgacac gggattattt 2240281 tgaatgccat gaaatattag aagaatattg gaaggaagat ccgccaaaga aacgaaaacg 2240341 ctattgggtg ggctttattc agcttgcagt ggctttatat catcacagaa ggcagaatac 2240401 agccggggca aaaagactga tggcgaacag catccggatt cttcaagcag aacaccgggc 2240461 agtcgaagac ttagggcttg atcatggccg tttgctcgaa cttatgcaat cggtttacga 2240521 acaaatcgaa accgtctctg cctataaaag cattatactg ccaatcaaag atgagaaact 2240581 ggaggaagca tgcaggatcg aatgcaggaa aaaaaagtat acatgggggc agcccagtgc 2240641 actcagcaac atatttctta tcgacaaaca ccgtttgcgg gatcggactg acgtcatccg 2240701 tgaacgtgaa aaagaaatag aacgcagaaa aaaaagcaga gactgatcac agcctctgct 2240761 taattattgt atgaaatgtc ttgatcctgc tgaccttgac aacgttcgaa aaagctctgc 2240821 gttaattcat ttggaaccag tacttgcgtt ttgaataaat gctttaaagc atccatcatc 2240881 tgttttccga ttccttgatg gcgatgagaa ggattcacac tgatatgccg gatctcaacc 2240941 tcagaatcct ttttttcgac tccgattgct ccgacgatat cctcgtcctc tttccaaaga 2241001 aagagctggc ggtctgtatc cgtttcgtag tccttaattg tctgctgaag ctgcttaagg 2241061 tctttttcat tcggcataaa cgaaagaagc cccatcgcaa tcttttcaaa cgatttttta 2241121 taacgaatta acataaaaac ccctctatat ccaaaatgtc cagtctgcta ttaacggata 2241181 cgaataggtg atccgttttc tcacattata tcattttcgc catattttta aactgttttc 2241241 agcaaattat tcaaatgagc ggtttaaatt tgccatttca atggcagaaa cagcacaatc 2241301 tacacctttg ttgcccgctt ttgtgccggc acgctcgata gcctgttcga tgttttcagt 2241361 tgttacaatt ccaaagatga caggtacacc agtagtgttt gctgcttgcg cgatgccttt 2241421 tgcagcttca ttgcagacat aatcgtaatg tgtcgttgcg cctctgatga cagtgcccaa 2241481 tgtgataata gcatcatatt tttttgtttc cgccattttt ttcgcagcaa acggtatttc 2241541 aaatgcgcct ggaacccaag ccacatcaat gtcatttgtg tctacgccat gtctgagcag 2241601 cgcatcttct gctccgctca gcagcttgct cgtaataaaa tcattaaatc ttcctactac 2241661 gattccgatt ttaagacctg taccaactaa atttccttgt atgatattca tatgattccc 2241721 atcctttttt gtgatatttg tgattagaaa tgaagtaaat gacctagctt gttcattttg 2241781 gtttgcaaat attttttatt gtgttctttc gcctccattt gaagcggcac tctttctgaa 2241841 atactgagtc cgtagccttc aaggcctgcg atttttcgcg gattattcgt caaaagcttc 2241901 atattccgga caccgaggtc gcgtaaaatt tgtgctccga tgccatagtt gcgaagatcc 2241961 ggcaagaatc caagcgcctc attggcttct acggtgtcat agccttgttc ctgaagctta 2242021 taagctttta atttattgat taaaccgatg cctcgtcctt cttggcgcaa gtacaggagc 2242081 actccacggc cttctgcggc aatttggttc agcgcggcgt gcagctgcgg tccgcaatca 2242141 cagcgatgag agccaaacac gtcacctgtg agacattctg aatgcacccg gaccaatacc 2242201 ggttcttctc cgaacggcac atctcccatc acaaatgcga catgctcttt tccatctacc 2242261 tcatttgtgt atccataaac cttaaatgtc ccaaaatcag taggcagcgt aatgtcaact 2242321 tcacgctcga caagtgttgt cagattgtaa cggtattgaa tcaaatcctt aatggtgatc 2242381 atttttaatt gatgcttttt cgcaatttca atgagctcag gcactctcgc catcgttccg 2242441 tcttcattca taatttcaca aatgacgccg gctcctggag atccgcaagc ttcagcaaga 2242501 tcaacagcag cttctgtatg gcccgctctt ttcaggacac ctcctttttt cgcaatcagt 2242561 ggaaaaatgt gccccggacg ctgaaaatca gatggcacgg atttgctgtc cagcaatgct 2242621 tgaacggtaa aagatctttc ttgagcgctg atacctgtct tcgtttcacg atggtctatg 2242681 cttacggtaa atgcagtgtg gtgagagtct gtattatgct caaccatagg gtgaagatca 2242741 agcctgtctg cgatttcctc actgagcggc gtgcagatca gtcctctccc atgtgtcgcc 2242801 ataaagttaa tgacttccgg cgttgcatgc tcggcaagag ccacaaagtc tccttcattt 2242861 tctctgtctt catcatctac aacgatgatg acttcgcctt tttttaaagc gtccagtgct 2242921 tcttctatcg gatgaaacat gcaaatcttc ctctctaaaa gccgttttcg cttaagaagg 2242981 cttttgtaat ggtttgttgg gtcttatttt cattggcttt atgcaaaaat cgatacatat 2243041 attttccgat catatcgcat tcgatattca ctttagagcc gatcgttttt tctgaaaaga 2243101 tcgtttcgct gatcgtatgc ggtattaagg agatcgtcac tgtgtcttct gtcaggccga 2243161 atatggttaa gctcacgcca tccacagtaa ttgatccctt taaaaccaat gtttttgtta 2243221 atgacgggtc catttttaaa tcatagtaaa ctgcgttgct tttctcttca attcgtgtga 2243281 tttccgcagt tccgtcgaca tggcctgaga cgaaatggcc tccgaaacgg ccgtttgccg 2243341 ccatcgctct ttccagattt actttgcttc cttttgttaa atcattcagt gacgtagctt 2243401 tgactgtttc aggcataaca tccactgtga attgattttt tgtaaaatca gtgacagtca 2243461 gacaaatgcc gttcactgca atgctgtcgc caagatgaac atcctctaaa atctttgagc 2243521 atttaatagt taaggccatt gcatgccctg cttttttcat ggattcgatt gtgcctgttt 2243581 cttcgataat tcctgtaaac atggtcacca tcctattcct ttgtcggttt tgccgtcagt 2243641 ttgatatcac ggccgatttg ggttatatca gtgaattgta ataaggggac atctttcatt 2243701 gattgaaaac cttcaccgga gattaagctg ggagcatgcg ttcctccgat tagtttaggg 2243761 gcaaaataga agatgatttc ttgaaaacag ccttctttga caaagcttcc gtgaacagct 2243821 gaaccgcctt ccacatacac cgacatgatg ccttcttccg ctaggatctt caaaacatca 2243881 ggaatttgaa tgcgctcggt ttcaagtgta aatatgttca ctccgaaagc tgaaagccgt 2243941 tttttctttt cctcgtctgc gcgtgccgtc gtaaaaatcc atgtcggcgc tatttgatcg 2244001 caaatcactt tagcgtcctc aggaatcgag agtacggtat caagtatgac ccgaaccggc 2244061 tgttttgtta cattcggcag tctgcaggtt aagctcggat tgtcggcttt cactgtgcca 2244121 actccgacta aaatgctttg gtgtgttttc ctgtattgct gagcatcctg tcttgcagcc 2244181 tctgacgtga tccatttgct gtcacccgtg ctggtagcta tcttgccgtc aaggctggca 2244241 gccgctttta gcgtgacgta cggaaggcct gtcctcataa agtgcagaaa tttttcattc 2244301 agcctctccg cctggtctgc caggatgcct tcccttacct caatgccagc ttctttcatc 2244361 atgctgatcc ctcttccagc cacaagcgga ttaggatctc tcatcgccac gaacactctt 2244421 ttgataccag agttgataat caattctgca catggcggtg tttttccgta atggctgcac 2244481 ggttcgagtg taacgtaaat gtcggcaccc tctgcatgtg ctccagccat atggatggca 2244541 tgaacttctg catgagcttc accatatttt aaatgggcgc ccattccgac aatttgtccg 2244601 tcctttacga caacagcgcc gacgagcgga ttggattcgg tctgtccttc gccctgcttc 2244661 gcaagatcta aggccagctt catataatac tcttccattt gtttccctcc cctcttttgt 2244721 tatttaccgt caaaaaagcc ccgaatttat aaaaaattcg gggctttagg tattttacgc 2244781 aataggaaat aacactatgc atttttaaac attttgcata gcggctcatc atccttctcc 2244841 catccagact ttcactgtcg gcttcagctt aaactgaatc caccgcgtgc ttatgcacac 2244901 gggtcacggg ctctaaagca aatgtgcttt actaccgccg gtcgggattt ccaccctgcc 2244961 ccgaaggata caatctttat tcatttgtcc ttattggtta ttatagcgat cctttttaaa 2245021 gtacgcaatg aaataaactt acaatttgag aaaaacaaaa catcaccctt cgatccgaaa 2245081 ggtgatgttt tttaatcatt cacttttgca accttgatta atccgtcgat ccgctttgat 2245141 ttgctgaagt aagccttaat cttgtcacct tcttttatat cagataaatc ctgatttaat 2245201 ttttttccgt tgaagatgat tttcgttccg ttttctgcta ctccatgata ctctgagccg 2245261 tcaattttcg tcactttata ttcctggatg gtgtattcct cttcttccga ggacaaggtt 2245321 tgtccaattg ctgtcggaac atccttcagc tcaatatcat ttatgtacat ataaccgcct 2245381 gcaagtaaaa gcaaaagcac taacagaatg gtaatcttgg tttttattct tcccatttct 2245441 aaacctccag ccaatatgaa tctattcatt catatgagtt attccttttt ttcatgaata 2245501 aaaaaccgta aattctcgta aattattaat ataacgatgc ataacgggaa tatgtttcac 2245561 atttctgcaa aaatttcttt tctatagata tacgaattta tgttctgttt ttaggggatg 2245621 accgtaaaaa agatataaaa aaagcagccc caatgggaag ctgcttgatc ctaatttgtt 2245681 ttgcgcattt cgttaaacgg gtagaaaaca aactttgacg tacccgcaat ttgttttttc 2245741 gtgaagaggc caaggccgtt acggctgtcc atggaattgc gacgattgtc acccatcaca 2245801 aaatacttgt tatcaggcac tttaaccggg ccgaaatcat cggtcaaatg gtcaaaaccg 2245861 tcctgtttcg ctctcttttt attagccgcc aaataaggtt cgtccacctt tttcccgttg 2245921 atatagagct ggtcattttt catctcaacc gtatcgccgg gaaggccgat aatacgtttg 2245981 acatagtgaa catcatctcc gtttaacacg acgatgtctc ctctatcaaa ctcgccgatg 2246041 tatttgactg tcatattaac aaaaaccctt tcacggttgt gaagtgtagg atacatagag 2246101 tcaccatcaa cgacatacgg cgcaaaaata aagttgcgga tgagcaaagc aagaacgaca 2246161 gcaatcacaa ttgcttttgc ccattctaat attgactttt tcttcgaaac attttctgat 2246221 ttcaactgat ttcctccaat aaacaacggt cttcaattta tgttatcacg aatcgaaaaa 2246281 aaatcccatt aggaccattg aagtgatttt acaaactgtt aatcttcatc ttctacccac 2246341 atcatgccta ttttttcttg tcgatcataa ctaggcctga aaatattgaa agaaatgaat 2246401 cgcataattc agaagcgatg gactcagaag aaagagagtt ctcatatgca aaatctttag 2246461 atcgtatata aagcatgagg ttacgggcag tttgttcatt tactgcattc cattgatctc 2246521 ccagtccatg atacccatgg cacttgacaa aacaattaac gtcatgaagg ttactggaat 2246581 gtttgcggca acctatttca caggtgataa ccgcaccccg ttttttgctt tcataatatg 2246641 tttaaaatca ttcaagctcg aaaacatgga tcagcctcca aaaaataaat ccaatatatt 2246701 cccggcagtt gaagactctt tattataaaa ctctgaatat ccgcagttct tacagtaaac 2246761 cactagaaat cggttatgct gcacgtcaaa cagctttgat aatcccgtgc cggttgtagc 2246821 tatttctttt tgtccggctt cagtactacc gcattttata cagcctttgt tgttcatatc 2246881 gcgatctcct tttcattaca tcacgtttgt ttgatttatt ttactacaaa atatcaatcc 2246941 caatgacccg tactacttta aagtttactt aattttgatt acatactaat tgggttcgtt 2247001 tctcagcttg gtaaatcttc tggagaaacg gaaaagctcc atgaccaaaa cattcaaact 2247061 cagccaaaca ccgccgaagg cgtaacccgc agcaacatca ctcggatact gctcataaag 2247121 tacacacggc tcagcccgat gaggaataaa acgataataa acaaaaaaat gcaacagttt 2247181 gcagacgcgt cttgtgagaa tgacgaacaa aaagataagc acaaaaacca aaaatgacaa 2247241 atgccgttaa agtctgttcg ctcgggaatg gatataatac atgactttcc aaaggagcgt 2247301 gaacaggatg aagggaatga aagagccgtc tgattccctc ttcataaagc tccccaccaa 2247361 tgactaggaa aaataagaaa gagagttcga ttttccgatc ttgccctctg aataccgtcc 2247421 aaaaaaaagt tagaacaata acggctaaca gaacacctct cgacgcaaaa gctttctgaa 2247481 ttgcagctgg gcccagtcta tacccgatcc aatacgacat gctcactccc acagctcccc 2247541 aatccggccg ctaacatgct tagcacccag tttaactttt cttgaaacac gagaacaccg 2247601 gcaaactctc ccggtccaag taaagctaga agctctaaca tcaagacaat aaacaagacg 2247661 gcatatccgt actgttcgag caaccccgtc aaaacttgca tgtgattctc cttaaacttt 2247721 tttgttcttt tatcattccc aatccacttt ttgtataatc agcacaattt tatcttcagt 2247781 cgtccaacaa cattgtctat ggcgggatct tctctcatac attctttttt gacataggag 2247841 gagcaatagc atgaaatggg aggaaacaaa agatacgcag ggagtttgcc aaaattttgg 2247901 gcagttcgtt ctgccaccga gtcaggtgtt tgtttgccca cctcatccct tgtcaattcc 2247961 ccatttttcc cgtttgaggt tcgaaatggt aaagtatttc acttagtttc ttacatgaag 2248021 aggtaaattc tttgctcacc gaactaggat agcggcgtat ggcgatttct acattgcata 2248081 accactggtt atttagtgag ccgtgagcaa tgtatatgca ctttgagtca gcacaggatg 2248141 atcctattac attcgccaga aaagcagctg ccgcattcag agtagttaaa agaatagaca 2248201 gatatctggg cttccggaag ctttaaagga ggctcttttt tcgagcattt ttataaatca 2248261 ataaaaacag gcatctccta aatatttttg ccgataagtt tacgctaatc aactctagca 2248321 ctaatacata taaaaaatag aatgatatga aaggagactt gatagtatga ttgattatcc 2248381 tattaatata aacaacgttt ccgggaacag tgtaattaac gtaggcggcg cttttatgat 2248441 caggccttta actttgtcca aatctgtgtt tggctccgga ggtttaaaca caggaattgt 2248501 ctttgaaaat aactttgtaa gcaaagctaa aatgattaat catcaattta ctgatcaaaa 2248561 cgtcaccaaa actttttaat gtattcaata cacgggggtc actaactaaa cacctggttt 2248621 tgccaaccgc catcagcatt cggcggtttt ttattgaaca tttttggcca ataaaaaaag 2248681 cttcctctct aagaggaagc cttttgcctg ccgattagcc ttctacacga acttctttca 2248741 tgacatcgcc attagacatg tttttcgcga attctaatcc gcttgttact ttaccaaata 2248801 cagtgtgaac accgttcaaa tgaggctgtg gctcatgaac gatgaaaaat tggctgccgc 2248861 cagtgtcttt tccggcatgt gccatagaaa gtgcgcccgc ctcatgtgta tgcgggttgc 2248921 cttctgtttc acatttgatt gtgtatcccg gaccgcctgt accagttccg tgcgggcatc 2248981 cgccttggct gacgaagcca gggatcactc ggtggaatgt aagcccgtca taaaagcctt 2249041 cgttcgcaag cttttcaaag tttgcaacag ttccaggtgc agcttcagga taaagttcaa 2249101 attcaatttt gttcccgtct tctaataaaa agtaacctgt tttcaattgt atgcctactt 2249161 tctttatttt aattttcaaa ggagattatg tataggttat agcctgtctc tccttgtcgc 2249221 ggctattata ccacaccttt cgggggaaaa cgaatctccc gagctttact aaaaaataaa 2249281 aatgaaacct gaatctcttt atctccgtct aacctaacgg aactgtattt ttcatgattc 2249341 aggtcctcac aaagcagcac tatccagctg cttgtgaaat tgaaggaggt caaactgctt 2249401 tgaagaaaat ttggattgga atgctggcag cggccgtttt gctgctgatg gttccgaagg 2249461 tcagtctcgc ggatgccgca gttggagatg tcattgtaac actgggtgct gatttgtcag 2249521 aatctgacaa acaaaaagtg cttgatgaaa tgaatgtccc tgataatgcc acaacggtaa 2249581 ccgtgaccaa taaggaagaa catgaatatt taggaaaata tatatcgaac gcgcaaatcg 2249641 gatcgagagc gatttcttca tcgtcaatca ccattgccaa aaaaggctcc ggattgaatg 2249701 ttgagaccca taatatcagc ggcatcacag atgaaatgta cctgaatgca ctgatgacag 2249761 ccggtgttaa agatgcgaag gtgtatgtta cagcaccgtt tgaagtatcc gggactgccg 2249821 ctttaactgg attgattaag gcgtatgaag tttcttctga cgaagcgatc tcggaggatg 2249881 ttaagcaggt cgccaaccaa gagcttgtca cgacatcaga gcttggagac aaaatcggta 2249941 acgaaaatgc ggcagccctg attgcaaaaa tcaaagaaga gtttgctaaa aacggggtgc 2250001 ctgataataa agctgacatc gaaaaacaag tggatgacgc agcttctgat ttaaacgtca 2250061 cacttacaga cagccaaaag aatcagcttg tctccctatt caataagatg aaaaacgctg 2250121 acattgactg gggacaggtc agtgaccagc tagataaagc gaaagataag attacgaaat 2250181 tcatagaatc agatgaaggc aaaaacttca tccagaaagt cattgatttc ttcgtatcta 2250241 tctggaatgc gattgtatct atattcaaat aagaaaagcg ccgaaaaatc ggcgctttct 2250301 tttattgctt tacacccgtt ttaaatggca gatcaagttt tacaatatct tcgtatgttt 2250361 ctcgcttcac gactaaatga gcctcaccgt tttcgacaaa tacaacggcg ggtctcggaa 2250421 tacggttata attgttggcc atgctgtatc cataagcgcc tgtacaaaaa acggcaagaa 2250481 gatcgccttc ttttacttcc ggcaggtcaa tatcccaaat cagcatatct ccgctttcac 2250541 agcactttcc ggcaattgat accgttttgt catgcgcttc tccgatcctg ttggctgccg 2250601 cagcttcata tttagcttgg taaagcgcag gacgaatatt gtcgttcatg cctccgtcta 2250661 cagccacata ttggcggaca cccggcactt ctttttgaga gccaaccgta taaagagttg 2250721 tgcctgcgtc tcccacgaga gaacggcccg gttcgatcca aatttccgga atgtcaaaac 2250781 cgtaacggga agcattttct ttcacagctt cgataatttt ttcaacgtat tcagtggcat 2250841 gaagcggttc atcatcttcc gtataacgaa tgccgaaacc tcctccaaga ttcagcacct 2250901 tggatacaaa tgaatatgaa tctctccatt cgtctagttt tttgaagatt ttttccgctg 2250961 ctaacacaaa accggccgta tcaaagattt gcgagccgat atggcaatgg acacccagca 2251021 gctgaatgtg ttccgattgt aatacttgtt caatggcccg ttcagtttgt ccgttatgaa 2251081 gatcgaaacc aaactttgaa tcttcctggc ccgttgtaat gtagtcatgc gtatgcgctt 2251141 ctactccggg cgtgatccga agaagaacat cgatggagtg acccgtttct ttacataggt 2251201 cttcaagaag cgcgatttca tagaaattat ccaccacaat gcagccgatg cggtgctcaa 2251261 gcgccatccg cagttcttcc ctgctcttat tgtttccatg aaagtggatg cgttctgccg 2251321 gaaagcctgc tgcaacagcc gtatatagct ctcctccgga tacgacatct aaagaaagtc 2251381 cctcttcctc agcgagctga atcattgcga ctgatgagaa tgctttgctc gcatatgcca 2251441 cctgtgcttt cagccctgca gaaataaacg cctgcttaaa gcttttagca cgctcacgta 2251501 ttaaagccac atcatatacg taaagaggtg taccatattt ctccgctaaa tagagagcat 2251561 ccacacctcc gatttctaaa tgaccatgtt gattttgtct gcttgtgccg tgtaagaaca 2251621 atgtcattcc ctctttctcc gcttatggat gaaaggacag ttttatggac tgtcccttca 2251681 taattaagac atacattatc atactcttca gtcagtttca atgcgattat gaattggtag 2251741 gctgccttaa gcgatttttg gggtgaacga tgctgggtct tacttttgcg ccaggtttcg 2251801 ctgtgcggac aagaacctgc cacagcgcct ttccgttaaa gggaatcagc ggccataagt 2251861 acggtgtctg aagggatttg atgcttgcca tggcaataat tagcactgta aatccgatga 2251921 cgagcccttt tatatgaaat aaagcaacga gtatcatgag gacaagacgg ctcattttgt 2251981 ttgccaagct taattcataa ctaggcgtcg taaaggttcc aatcgccgca agtgagacgt 2252041 acagaatcac ctcaggagaa aaaaggccga cctcaatcgc aatctgcccg atcagaacag 2252101 cggcaattaa acccattgct gtcgataaag ccgtcggtgt gtgaatggca gccattctga 2252161 gaaactcgat tcctaagtca gctaaaaata tctgcaggat gatcgggata tgcgtatctt 2252221 tatttaaacc gataaatttc atgttgtccg ggagcagatc aggctgaagc acaaagagaa 2252281 accagatcgg aagaaataaa gtagaagcaa gaataccgaa aaatcttacc catcttaaaa 2252341 aggtcccgac tgaaggcgcc tgcctatatt cttcagcatg ctgcacatgg tgaaataaag 2252401 tcgtcggggt aatgatcaca ctcggcgatg tgtccactat aatgataaca tggccttcta 2252461 gaacatgatt tgcggccaca tccggtcttt ctgtatagcg cacgagcgga aaaggattat 2252521 agctttgatt aacaatgaat tcctcgacag ttttgtctgc cattgttaat ccatcgacat 2252581 caatggatgc aatttctttt tctacgatct caaccagatc cggatcagct atatcttcta 2252641 tataacaaat gcttaaatcc gtctttgacc gctcaccaac tttagtcatc ttgactcgaa 2252701 ggcgttcgtc tctgatccgc cttctgagaa gggccgtatt gacgacgata ttttcaacaa 2252761 atccgtctct ggctcccctg accacctttt ccgtatcagg ttcttccggg tttctgcccg 2252821 gatagcttct gacatcaatt ataaatgcga agcctgcacc ttcaacaatg acagcgacga 2252881 gcccggacag cacttggtcg gtggtttcat ccaaggtttt tactttttcg acctgggcgt 2252941 taagcagcct gttttcgacg atgtcgacca gctcatcagg gtcttctttc cgattgttaa 2253001 tggcaacaag ctctctcatt aaatgaataa tataggctgt atcgcataat ccatttagat 2253061 agtaaagctg gatctcttta tctaaaatcg tgagcttgcg aacacctaca tcatagctcg 2253121 tccccatccc aacacggttt ttgaaatact cttcattttt agctggattc cgataaaccc 2253181 gaattttctc ttccttgtgg tccggcatga tacccgctcc tttctaaaat aaactcgacc 2253241 gctttcatgg tgattggcga cccttttgag atatcgtctt ttctgcccat tttgccgata 2253301 tccccgatac cgacaataag cgggagatca agtttatcaa ggcaatagac tgtatctcca 2253361 ctcattctgt ggtcatcaaa ttccctttcc ccgactttat cgacgccgta ttcagttatt 2253421 tctccattgc ggtcaatgct tacatcgacc ctggtccatt cagcctgatg tgtttttgac 2253481 gcgaccgcaa tcacaccgag cacttcaata gacggatggg ttgcgacata ggttagagcg 2253541 gcttctcccg ggccctctcc ttgaaggccg gagtcgtcaa acatgacaaa tacaggatca 2253601 tacggtgctg aggcgatcag cttgacaagc tcggcgccgc tgcgggtgga aggattccct 2253661 tttgattgtg aaatacatcg gcctcccact ttgcttgcgg cgtattcaat tgttttagcg 2253721 gcataaacat ccccgtctgt taccagtatg accttgcgtt ttgtcgtcat gtcggcatta 2253781 tcctttcggt ttgaaaataa cagctacgat aaaggcgaaa agaatagcgg ctgagatacc 2253841 ggccgaggtc agctcaaaaa tccccatgcc gattccgata aatccgtgta tatgcgcctg 2253901 atgcatggcg ccgtgcagaa gactgtgacc gaagctgacg atcggaacgg tggcgcctcc 2253961 tccggcaaat tcaataaatt tatcgtaaat gccgaaacca tctaatattg caccgattac 2254021 aacaaatgat gtcatgacat gagctggcgt caatttaaaa atatccaaga gcagctggcc 2254081 gacgatacag atggccccgc cgcagacaaa agccaaaagg tagtccatat taagatgcac 2254141 ctcctgcacg ctcaaataca accccgtggg cgatagtcgg gatggtttct ttttgctgga 2254201 tcatcgtcgg gcttaatagc gccccggtcg ccacgacaaa tacacggttt agttttcctt 2254261 ctctcagctg cttaaaaata tgagagtagg tgacaaccgc tgaacaagca cagccgctcc 2254321 ccccggcaaa gacctgctga tccggagtgt aaatcagaag cccgcaatca tcatgctttg 2254381 tgccgactgg atatccatct tcttttaaaa tgtcttttac gattggagaa ccgacgcctg 2254441 acaggtcacc tgtcaggatt agatcatagt catccgctgt ccggttgaga tctttaaagt 2254501 gctgcttaat cgtatcagct gcagccggag ccatagccga tcccatatca aaaggatctg 2254561 taattcctaa atcagaaacc ttcccgacag tcgcacttgt gatttggata tcacccggtg 2254621 tctgactgat gacaactgca ccgcttccgg ttacagtgga ggtagcagtg tccggttttt 2254681 ggcctccgta ttctgtcgga tagcgaaact gtctttccgc agttgcattg tgactgctgg 2254741 tggcagcgag tgcccttttg gcaaaccctc catcaactaa ggctgatgcg acagccactg 2254801 tttccattga tgttgaacag gcgccaaaca tacaaagaaa tgggattttc aagtgtcttg 2254861 ccacatagtt agccgtcacg ttttggttca gcaagtcgcc tgccagcaat aggtcaatat 2254921 catcttttgt cagattgttt ttttgaagtg caacattaac agcgtcttcc atcagctgcc 2254981 gttccgccat ttcccagctt ttttgattac aatgcatttc gtcataggtt ttatcaaata 2255041 aagagccaag cggtccgtct ttttcctttg gtcctgctgc cgttcccgct gagttgacaa 2255101 atatgggatg ttcaaatacc caggtttgct ttcctgttaa tttcattttc ttctcctcct 2255161 atgacatcag tttctcaaaa gcaaaccgaa tcattccaac gatgtatgca gctacaactc 2255221 cgaaaacaat aacatttcct gccagtttaa acatatttgt cgctactcca agcactaatc 2255281 cttcgctttt atattcaaga gccgcacttg ccatactgtt ggcaaaaccc gtgacaggta 2255341 cggctgaacc tgcgcctgcg aattgtccga ttctgtcata gattccaaac cctgtaagca 2255401 gggcagaaat taatatcagc gttgcagctg ttggattccc cgcagttttt tcattgaaat 2255461 caaaaaaatg gatataaaaa ttttgcagac cttgcccgat tgcacaaatc agtccgccca 2255521 ctaaaaaggc ttttacacag ttccagacgt aaggcggctt aggctgatat gttttcactt 2255581 ttgatttgta attttctttt atgtttgtca tcttgaaacc tccttatgaa tggtcaataa 2255641 agtacagcca gtgaaataaa gatcccgcga ttttcccaat cacgatggcc attaacagaa 2255701 taatgatttt acttctgagc ccgattcgtt tcgccaaaat cggcaggaca tttaaaacct 2255761 ctgtaagagc agccgctagc atcccgacga acaaacctgc cagaagcccg accggcacag 2255821 ctatccattt tgttagataa agatgattca tatgaagcgt ctcccatccc ccgcaaaccg 2255881 cgccaagaat aacagccgct tcataagcct gaacaaatct cattgttttg gtgagctgca 2255941 tcagccgcgg aatgattccc attacggtta aaaaagcaac gaaacccgcc cccaccgtta 2256001 tgcctccgcc gagcccgaca aaaatgatga acaatacact aacgatcatg cagatccttt 2256061 atggtttctt gattctcatg catggccaca tattgatcga gatcaagctg atagttaaac 2256121 atctcaacct ccagcgggct gggctcttca tttaggcgct ttttaaatat gtggttaaaa 2256181 aacacgatca tccccagtcc caaaccgatg ctgtatggga tttgaagcaa atatggatag 2256241 tcattcctct ctccggttat gatttcatat agtgcgatat gaacatctct catgcttaca 2256301 tcctcatgaa agttcatgat ggcaagacac gatccaataa acagaagcag ccagacaccg 2256361 ataaatagaa ccgttgataa atttcgcttt cgatactgaa tttcaacaat ggtttctgct 2256421 ccgcctacgg tttgaacatc aattgtcggg tcttgtaaat gaatggctct gaggacttgt 2256481 atgatatcca gaattacgat atttttatct ttttcgctca cctgataaag cggcatagcc 2256541 gaaagtttct ttttcagctg aagctgccct tctatttgcg cggcatctcc aacggtaata 2256601 atatcccctg gatgtgccag cactcggtgg cgaagccgga taaatattcg tcgttccatc 2256661 attgatcacc atctttcggt ggttatatat gtagtatgtg gttcgatttt gttctcattc 2256721 atccgctcga aaagaccata aattaccacg cttttgcaca aaaaagctag cctgcactgc 2256781 agactagcca tccgtatgat ccatttgaac cttgatctgt tttaatattt tcttttcaag 2256841 cctggaaacc tgcacctgag agatcccgag ccgctcagcc acctcggact gtgtctggtc 2256901 tttataatat ctgagataga cgattagttt ttccctttcc tccaaatcgc tgatcgcttc 2256961 tttcagcgca attttgtcaa accatttttc ttctgagttg tcagcgattt gatcaagcag 2257021 ggtaatcgga tctccgtcat tttcataaac ggtttcgtga atcgaagatg gagcccttac 2257081 cgcctcttgg gccagtacaa catcctcagc ttcaatctcc aaatggtcag cgatctcctg 2257141 caccgtcggc actctgccca gtgttttcga aagctcatcc ttcgcgcgcc ggattttgtt 2257201 tccaagctct tttaatgacc gtgatacctt tacggttccg tcatcacgga taaatcgttg 2257261 gatttctccg ataatcatcg gcactgcata cgttgaaaaa cgcacatcat aggttaaatc 2257321 aaatttgtca acagatttta acagcccgat gcagccgatc tggaagagat cgtcaggctc 2257381 atatcctctg tttaaaaacc gctgtacgac agaccaaaca agacgcatgt ttttttctat 2257441 gaggaggtct cttgcctgct ggtcgccatt ttggctttgt ttgattaatt cctttacttc 2257501 atgatccttc agctgagcgt ttttgccgtt tttcttaacc tccacatcca taacaaatct 2257561 ccttaattac aaagcgcttt gctttttgat aagtgctttg ttaagcgaat cgttgttccc 2257621 atttcaggcg atgaatcgat actgacatca tccatgaaat tttccataat ggtaaagccc 2257681 attccagagc gctcaagctc aggcttagtc gtaaatagag gctgacgggc ttcttcaaga 2257741 tctgtaatgc ctaagccttc atcacgaata gtcatatata cgacatgatc ttccagcgtc 2257801 actgaaatgt aaactttccc ttcacagttc tcttcatatc catggataat cgcattcgtg 2257861 acagcctctg acacgactgt tttgatttca gtcagttcat ccattgtcgg gtccagctga 2257921 gctataaatg aagcaactgt cacacgggcg aacgattcat tctgactgag ggcagaaaac 2257981 tcaaggtgca tttcattttt catgatgcca cccccagtgt caggagtgcc tgctgttcag 2258041 attgttcaaa tcggataatt ttaaacagac ccgacatatc aaacaatcgc ttcaccgcag 2258101 gagagatagc gcaaacaacc atttctccgc caatttgctt aatttgcttg tatcttccta 2258161 aaataacgcc aagccccgag ctgtccataa aggaaaggtc ctccaagttc agcacgatat 2258221 ggcgaatatc atccttctcc aatgattgag tcactttttg cttcagggtt tcagccgtat 2258281 ggtgatcgag ttcgcctgtt aatcgaatac aaagcacaga ttctttgaca ttcatgtcaa 2258341 ttccaaggct catgctcatt cctccttgat atgatcggat aatgagtgtt tcgatttcga 2258401 cggaatgaat tccttcaccg tgacaaaact agtggtcatt cggcataatt acttaaattt 2258461 tgtccagtct cccatcgtcc gctttaagaa tgtgataaac ccggctttct tcatatcttc 2258521 ttttgcagca acaggacttt cagcgagtac ttctccatcc tttttcagaa caagagtgcc 2258581 aagctcttgg cctttttgaa tcggagcact aatattgtcc ttcatcttga tttctttttt 2258641 cacatcgttc atatcctcgc cttttttcgt caatattgaa atcggctcag atgtagtgag 2258701 ttcgataaat ttttgtttcc cttttttgac ctttactttt gctactgttt gatttcgttt 2258761 atataaagga tgcgtttcat attggctaaa ggcgaagtca agcatttttg tcacttgcgc 2258821 gtttctttct ttaggcgtgc tcgctccgaa tacaaccgct atggcccgca tgtttccttt 2258881 tttagccgaa gcagtcagac aatatttcgc ttcgcctgta tagcctgttt ttacgccgtc 2258941 tacaccagga taaaatttga taaggcgatt tgtatttaca agccaaaact ttttatctgt 2259001 attttcacgc agataatctt catacgtgcc ggtaaacttc gtaattgatt cgtatttcaa 2259061 taattcctta gccatgattg ccatgtcata agcagagctg tagtgtcctt cctcggtcag 2259121 tcctgttggg tttttaaagg atgtattttt caatcccagc tcttttgctt ttttattcat 2259181 tttcttcaca aattcttctt cagagccgga aataaattca gccatggcga cggaagcgtc 2259241 atttcccgaa gcgattgcga tgcctttcag catttctttg acagtcattt cttcgccggg 2259301 ctcaaggaat atctgtgagc cgcccattga cgccgcatgc tcgcttgtac ggaccttatc 2259361 actcattttg attttgcctt tatctaaagc ttccataatc aaaagcatcg tcataatttt 2259421 cgtcatgctt gcaggcgcca gtctctcatt gctgttcttg ttgtaaagca cttttcccgt 2259481 gtcacgttct atcagcaccg cagacttcgc ttcatgagca agctccgatg tacgttttcc 2259541 gtcttgtttt gcaaatgcag acggtgcaaa tgtaagcagc attataccaa tcaacaaagt 2259601 ggataaaaga cgtttcatct caaaagccct ccatttcata atccttttta ttttttccaa 2259661 gcgtgatggt tttatacgcc actgatggaa aatgtttcga attttgggca taaaaaaaga 2259721 cagctgtgtg atatcagaca cagctgtctt ttggtcctgc attgattcat atttattcgt 2259781 actgagcgac gatcgcttta acaagcttta agaatccagc ttttactttt tcggtcactt 2259841 ccataacttc atcgtgactt aaaggctgat ccagaattcc ggctgccgcg ttagagatgc 2259901 aggaaatgcc aagaacccgc attcccgcat gattcgctac aatgacttcc ggaacagtag 2259961 acatgccgac tgcatcagag cccatcgttc ttaagaaacg gacttctgcc ggtgtttcgt 2260021 aagaaggtcc tgtcacagca gtgtacacgc ctttttgaat tgggatatta aggtctttcg 2260081 caatcttttc agccaggctg gacagatctt tgtcataggc tgaagacata tctggaaatc 2260141 tggcgccgaa atctgcttcg tttggcccga ttaacgggtt tgttcccata aagttgatat 2260201 gatcggtaat aatcattaaa tctcccgcac ggaattcagt gttgacaccg cctgcggcat 2260261 ttgtcacgat caacgcttcc acaccgagcg ctttcatcac gcgtacaggg aatgtgactt 2260321 tctccattga gtagccttca taaaaatgaa agcggccctg cattgcaatg acggaaactc 2260381 cttcaagagt gccaagcaca agctgtccgg catgcccttc aacagtagat accgggaatt 2260441 caggtatatc ttcatatttc agcttgaccg gattttcgat ttcgtccgcc aaaatgccaa 2260501 gacctgagcc taaaataagg ccgatctttg gagattccgg caggttttgt ttaataaaag 2260561 cggctgcgcg ttcaattctg tccttcaaga aacagtcccc ctattgtaat aaagataaaa 2260621 agcttttccc gtatttcggt ttatttgttt ggaaattatc agcgatcgtt gcgccaatat 2260681 cggcaaatgt atctgcaagc ggcagcattt gcgctttctt atgttttttg ctgtaagcga 2260741 gaatcggcac atactcgcgt gtatggtcag tcccatgatg aatcggatca ttgccgtggt 2260801 cggctgtaat aattaacaga tcgtcttctc tcattttttc aaacacttcc ggaagccgcg 2260861 catcaaattc ttcaagcgcg cgtccgtagc cttcagggtc acggcggtgt ccgaataacg 2260921 cgtcaaaatc aacaaggttc gcaaagctca gacccgtaaa atcttctccc agcgtatcga 2260981 tcaccttgtc cattccgtcc atattagaaa ccgttctgcg tgaagaagta atgccttctc 2261041 cgtcgtaaat atcagagatt ttaccgattg aaatcacatc taagccgcag tctttcaatt 2261101 cattcatgac agtgcggtca aacggcttca gcgcataatc atggcggttt ggcgtccgtt 2261161 tgaattgacc cggctctccg acgaacggcc gtgcaataat gcggccaacc atatatttcg 2261221 gatcaagcgt cagctctctc gccgtttcgc aaatgcgata cagctcctca agcggcacaa 2261281 cctcttcgtg agcggcaatt tgcagaacag agtcagcaga cgtgtaaaca attaaagccc 2261341 ctgtctccat gtgctcctgg ccaagctcat ccaaaatcgc tgtgccggaa gccggcttgt 2261401 ttccaataat tttgcggcca gatctctttt ccagctcttg aagcaattca tcaggaaagc 2261461 cttccgggaa cactttaaac ggtttatcaa tgtataaacc cataatctcc caatggccgg 2261521 tcatcgtatc tttgccgttt gacgcttctt gcatttttcc ataataggca agcggatgtt 2261581 ctgttttttc tacacctttg atatcttcga taagaccaag gccgagcttt gccatattcg 2261641 gcatatgtaa tccgttcata tgctcggcaa tatgaccgag cgtatgagcg ccttcgtcat 2261701 taaagtcagc ggcatccggc gcttcgccga ttccgactga gtccatcaca attaaaaaca 2261761 cacgattata tttgtatgca ggcatcttga aagcctcctt tttttctata cgtctattgt 2261821 atcgctaaga ggtctgacaa ctcaagtata aaccgttttc attcccgttg acaatgtatt 2261881 tggaaataat gagaaacttc aatattttct gtcgctctaa acaaaaaagc cgcagccacc 2261941 tgcggctatg ctcgcggatg aaactgcttg tacacatcct tcagccttgt tttcgtcaca 2262001 tgcgtataaa tttgcgtcgt ggatatatcc gcatgaccga gcatttcctg caccgctctt 2262061 aaatctgccc cgttctcaag cagatgcgtc gcaaaggaat gcctgagtgt atgcggagtc 2262121 agctctttct taatgccggc ttccaatgcg atttttttca ggttcttcca aaatccctgg 2262181 cggctgatct gtttgccgtg atgatttaaa aagagggcgt cagatacatt attttttaac 2262241 agttttcccc tggcttttgt catatattcc tcaatggcgg aagcagcggc ttcaccgatt 2262301 ggcacaatcc gttcttttct tcctttgccg aagcatcgga taaaccccat agataaatga 2262361 acatcagccg ttttcaattc aatcatttca ctgactcgta tgcctgtcgc ataaagcagc 2262421 tccagcattg ctttatcccg atatccgaaa gggctcgtca gcttaggcgt gtccaataac 2262481 cgctcgactt cattgagcgc gagcaccttc ggaagcgccc gttccgtctt ttgtgtttcg 2262541 atatgaacgg aagggtcctt atccgttact ttttccctga gcagaaattg atgaaaagag 2262601 cgaatggatg ccaaatgccg cgccgatgtc ttgccggatt tccccgagtc cttcaaatgc 2262661 tttaagtatt ggataatatg tatgcgggta acgtgattcc aatctgtaac atgaagggtt 2262721 tctgttaagt agagagaata gcttttcaag tcacgttcat aggatacgat cgtattttga 2262781 gagagccctc tctctaccat aacgtagtgg atgaaatcct ttatttgatc tttcactctt 2262841 gatctactcc ccgttttggt aaaaaaagat caaccggtcg aaccatccgc ctttttcatc 2262901 ctgatccatt tcaacaactt ttacagcgga gccttccggt ttatcatacc gatgatagtt 2262961 ttcatactct tgattcaccc atatcatagc ataatagaac aaagcggtaa aaccggtaaa 2263021 caggatgaaa actttcaatg catcgacagc tgttttcagg aatcttccca tgtcctaatc 2263081 gatcctttcc ctatggttcc agttatataa accatatgcc aaatcagaaa ggttttatac 2263141 atagaaacag caaaaaaccc tttccccatg agaaaaggtt cgcgctcggc accgtctatt 2263201 cagtttcttt tccgttacag cggtggcaaa tgccgtgaaa cgtcaatcta tgatctttaa 2263261 tcttaaattt ccaatcacgt tcaatgattt cttccacgtc ttcaagcaaa tcttcttcaa 2263321 tttcatcaac ggctccgcac tccatgcaca ccaagtggtg atgaaagtga gctgcgccct 2263381 ctttccgaag gtcgtaacgg gacacaccgt ctccaaagtt aattttatct acgactttta 2263441 attcagttaa taattcaagc gtacggtata ctgtagcgag accgatctca ggagatttct 2263501 cttttacgag gaggtataca tcttctgcgc ttaaatggtc ttcttcgttt tcaagcagca 2263561 ctcttactgt cgcttcacgc tgtggcgtaa gtttatagct ggatgagtgc agttgtttct 2263621 taatacgatc aatacggttt tccatgtctt tccctcctac gccgcattcc atgactcatt 2263681 ataacaaaat acgcgcagag ttccaactat aattattata aactgataaa taaaatggtt 2263741 ttcttttaat aatgatttta aaaaagtcta gatgtaagct tttccattaa aacaggagat 2263801 aagtatgctt caaagagaga tgaaatcagc gctaaaaaca gaatgaccag cagcacaaag 2263861 gcataccgcc cgaaccattg aatcggcgcg tcatgcaggc ttcgtttcac gaacagctgt 2263921 ctgattaact ttaaagaaaa cgcaattgca catgtgccca taatgagata agccggaatc 2263981 agcagcacat tttgcggcaa aacggagaca aatgatagga aaaacccgct tactcccatc 2264041 tgattgacta ggaacccgac agtaaagccg acgacgatcc ctttcagaaa gatcataatg 2264101 aaaataatcg gcatcccaat gacggaaatt cccagtatcc acatcaggcc taaatacttt 2264161 gcattatgaa agatactttg cccaaacata tcagctgaac ttgcctgttt tccatccgaa 2264221 agctgtccaa aaaattgact taagtagtag tataaatctt ctttctggct gatggtcata 2264281 ctgttgacaa taatcgcgcc aaagatgaca cccatgaaaa acagcactga cacaaatata 2264341 taaagagaga gatgatcttt gacatgcctg agaaacatgt ccttataaga gatttttcgc 2264401 ataccgtttc ctcccgcccg ctctagtgat ttgatttaat agattgtatg aaagaaacag 2264461 aaaaacatgc cctttttcaa aaagaaacaa tagagatgaa tgctaggcgg ctttttgggg 2264521 cacaaaaaaa tccttatcat caactgctgt atgatcataa ggattcttat gcttccgttt 2264581 attcaaaatc tcttttttgc tttttgtcat tcttccatgt gtgctgaaag atggtgtgct 2264641 gcctcttgat aataagacgt cacgtccgcc gtttctcaat cgatgccccc gcttcttttt 2264701 cgcttggctt tttgccatgt gatcactccc ttttttattt tcatagtaat gataacaaaa 2264761 ttgaacaatg ataagaaaaa aacagcacct gctacgacag gtgctgttta gctacattta 2264821 tttcactgct gtaagagctg catgctcgac agctgctgct accgcatgat ggacttttga 2264881 atcaagcggc tgagggacaa catcaccttg tttagtgcaa gctgcgatgg cctctgctgc 2264941 tgcgacaagc atatcatgat taatctccgt gctttttgcg ttaagcgctc ctctaaaaat 2265001 ccctggaaaa ccgagtacat tattaacaga acgcccgtca gctgcatatg cggcgccagc 2265061 ctgcagtgcg gcctccggct caatttccgg cttcggattc gataaagcca gaatcacttg 2265121 accagaacgt acaaatgccg gttttattaa acccggaacg cccgttgtag caatgacaat 2265181 atcacatgtt tccataagct cctcaatact ggaaactgcc tgtccgccgt attgttcgag 2265241 acggttcatt gctgactctg atttgtctgt tccgtataca gcattcacac cataagccat 2265301 gaacatccgg cagatggcca cgcctgctgc gccaaggccg atttgcccca ctttcgcttc 2265361 cttcaggtca acccccgcac tcctgcatgc cgaaatggca gctgccagcg tcactacagc 2265421 tgtaccatgc tggtcatcgt gcataacagg gatgttcagc tcctctttta ggcgatcctc 2265481 gatttcaaaa caatgcggcg aaccgatatc ctcaagaagg atgccgctaa agcccggaga 2265541 aatatgtttt actgttttga tgatttcttc aggatcactc gtatcaagca gtatcggaat 2265601 gccgctaata cccgccagct gatcaaataa agcagccttt ccttccatga caggcatgcc 2265661 agccacagag ccgatattcc caaggcctaa aattgcggtt ccatccgtta caattgcaac 2265721 agaattgctg atcgttgtat aaatagaagc tttttcaggt tctttttcga tcagtcggca 2265781 cacgtccgca acacctggtg tgtagacacg tcccagctct gccagtgaac ggatcggcat 2265841 tttgcttttc atttggattt ttccgccttc atgtgcggac aggacttcat cagatacggt 2265901 gtgaagcctg atcccttctc cgagggcctg tacagccgcg atcacttcct gaagctgttc 2265961 ttcattctcc acttgaacgg taatattccg cattgtgtaa ttgggtccga cttttaccgt 2266021 ctccacttca ccaatatccc cgcccagaag gccgatggcc gtagccaccc ttccaagatt 2266081 tccgggaacc gaaggcgttt cgatcatcag tgtccgaatc atgtgtttcg ctatcattca 2266141 gtgatcctcc cctattagcc tagtttttcg gctttaactg tattgttttt cgtataccat 2266201 ataaattttc ctgtataacc atagataatt gcaagaccta ttgctacaaa actgagccac 2266261 ataaacggca gataagagaa ggtagaaaca cctaaaatac cagccatgta aatcccatta 2266321 tcagaccaag gaaccatccc cgaagtcaat gttcccccga cctctgagtt acgtgataac 2266381 actcttctgt ccagatgtaa gcgatcatag ctgtcttcca taattttcgg agtcaaaata 2266441 agagatacat acatcgcaca gccgaagatg tttgctaaaa acgctacgat cagtgtagac 2266501 aatgtgacat tgccggctga agttaatttc ttttcaaacg ttgaaacaat gacttttaac 2266561 acgccgagtt tctcaagcag accgccaaaa ccaaggccaa agatgatgac gacgagagaa 2266621 tcaagcatac cgacaattcc accgcggttt aacaagccgt tcaaaaattc aacatccgtt 2266681 ttaatagaga agccgttgta cgcagttgca atcgcatggg caatatccat tccttggaaa 2266741 acaacagccc agattgcacc gagtaaagcg ccaattacga taactggcat agatggcttt 2266801 ttcatcgcca ataagactat gacgagaact gccgggatca gcatccaaat atgaatgtca 2266861 aacgtgtttt gcaaagatga ttttaagaat tcaactttat caagatcaat atttttcccg 2266921 ccgtacataa atccaacaac tgtaaagagt atagctgtaa tgacataagc aggtattgat 2266981 aaataaagca ttgctctcac gtgagccaat acatcgactt ttgatagtga agaagctaga 2267041 actgtactgt cagacagcgg agacagcttg tccccaaaat aagcacctga aagaatagct 2267101 cccgctacta gaggaagcgg aatgcctaac ccctctccaa ttgcgatcat ggcaatgccg 2267161 gcagttccga ctgttcccca tgacgttcct gttgccacag acataatgga acaaataatt 2267221 aacgttgcca gtaaaaagat acttgggtga ataaattcca gtccgtaata aatcaaagtc 2267281 ggcacaacgc ctccggcaat ccatgttccg atgagcgccc caactgaaac gagaatcagt 2267341 acggcttcaa ggccatttga tatcccatgt acaatcgcat tttgtaaatc tttataagaa 2267401 taaccgagtc taatacctaa aagcattgca ataaaccatg aaacaaaaag cgccagctgt 2267461 atcggcaagt cgagaaagac tgtaaacgat agaacaagtg ctaaaaatac tcctagtaca 2267521 ataataattt caaatagtgt tggcaatctt acatccttca aaagaagtcc cccttcatgt 2267581 aaaagctaaa acgctttcaa tatatagtgc aacacgtata ctatacttcc tcatccctat 2267641 gttgtaaaca gcttattcat ccgactattc ggagatgaat aagctgtatt ttatacaaat 2267701 tttatttttc taatagttct ttccctgcga tacctggttt ggtcatctca tatgggttta 2267761 aaataatatc caattcttct tcagtcagca catcatgctg cagacaaaga tcccggacag 2267821 attgccctgt cataattgct tccctggcaa ttctagctgc cgcttcatac ccaagatgcg 2267881 gattgacagc tgtgatcacg cctgcgcttt tttctacgta ttgcttcata cgcttttcgt 2267941 tggcttcaat gccttttaag cagttgtcag tgaacgaacg gaagccgttg ttcatgatgc 2268001 tgatggattg aagcaaatta aagacaagca cgggctccat gacgttcaac tcaagctggc 2268061 cggcttctga agcaaggcag attgtattgt catttccgat aacctggaac gcaatttggt 2268121 tgatcagctc cgccataacc ggattgactt tccccggcat aatagatgaa cccggctgac 2268181 gtgcaggcag agaaatttcc gcaagtccgg cgcgcggtcc cgacgccatt aagcgcaggt 2268241 cgtttgcgat cttcgacatg ttcatcatgc agacttttaa tgaagctgat acctctgtat 2268301 aggcatctgt attttgtgtc gcatcaacaa gatgatcagc gccgacaaga ggaagcccgc 2268361 taatatcagc aaggtgcttt actacctgtt tgatatattc aggatcagcg ttcagccctg 2268421 taccaacagc agttgcgccc atgttgactt catacaggtg ctggcgcgat tgcttgattc 2268481 gtttgatatc acgctcgaga acacggctgt aagcttcgaa ttcctggcca agacggatcg 2268541 gaaccgcatc ttgaaggtgt gtccggccca ttttaataac agagtcaaac tcctgtgctt 2268601 tttgcttaaa cacactatgc atatcttcca ttgttttcag cagtttttct aagagcttca 2268661 atgtggaaat atggatagca gtcgggaaca catcgttcgt agactgtgac atgttcacat 2268721 gtgtgtttgg acttaaatgg atataatctc cctttttatg tcccatgatt tcaagcgccc 2268781 ggtttccgat aacctcattc gcgttcatgt tcatagaagt tccggcaccg ccctgaatcg 2268841 gatcgacgat aaactgatcg tgccacttgc cttccagaat ctcgtcagcg gcttgtacga 2268901 tagcttggcc aattccttca tacagccgtt tcacgtccat gttggcaaga gccgcagctt 2268961 ttttcacaat cgccagtgcg ttaatcattt cctcatggat tttgtatcct gtgatcggaa 2269021 aattttcaga agcacggagc gtctgaattc cgtaataaac atctgcttca atttgttttt 2269081 ccccaaggaa gtctttttcc acgcgatatt ctttttggcc gtttaacata atctttaacc 2269141 ttctttctct ttgctggtta tcgtttttac attttacagg acaacgtcat cagctatcgg 2269201 cgtttccata attctcttga cgacaggaag atccgaagac tgacctagcg cccacatcaa 2269261 ttttggcaca attgcttctg tgttcatatt tcttgatcgg ataattaagt cttggttgac 2269321 tctgcggcca acctcgtaaa tgctcatgtc ttcgccttct tcaagacatt gagtcgtaat 2269381 gacgacgaca atgccgcttt cgatcagttc attcactttt gacaaaatgt ctctgccttc 2269441 aaacggcact cctccgctgc cataactctc aatgacaatt cctttgtaca tgcttttcag 2269501 ggcatcaaac atttcgggct ttaagcctgg atgcagcttc agcagacata catctgtgca 2269561 tagtgaagtg tcaactgtga aggtgtcgtt ctcaggttcc gttacttgtt tgttgtattc 2269621 gatcccgtct tcattgataa aagcgatata tgggtaattg atgctttcaa atgcgtcgta 2269681 gcttttcgtt cttaatttga tcgcacgcgt tccctgaatg actctgccgt caaacacaac 2269741 ataaacgccg cccacgcctt cacaggcaaa tcgaatggca tctgtaatat tttttttggc 2269801 atcggttttt tggaacgtga tcggaatctg cgagccggtg atgacaatcg gctttttggc 2269861 atgctgcagc atatacgata gtgcggcaga tgtataggcc attgtatctg taccgtgagt 2269921 aataacaaac ccgtcatagg catcataatt ttccttaacg gcttctgcta tttccaccca 2269981 gtattcaggc tgcatattgg tgctgtctat attcataagc gactgagttt ccattgtgta 2270041 atcgttatca agttttgata cgtaacttaa taattcatca gccttgactc cgggagccag 2270101 cccattttcc ccttcaactg aagcaatcgt tcccccagtt gtcaacatca ataatttttt 2270161 cataccatgc acctcttcac tgtatctaaa gatgggttgc gagaaggtat tcgcttttcg 2270221 catactttta atgcaattat agacacggaa aataaaatac gcaagacatt attattcaat 2270281 tcgcgtacac ttcctaatac ctatatgata taatcagctc aaggtgaaaa aggagcggaa 2270341 gttcatgaat ctagatcgtt taactgaatt gagaaaaaag aaaaattggt cgcttcaata 2270401 tacagctgac cttctcggta tcgcaaaaag cacatatgcc ggctacgagt caggctaccg 2270461 acggccttca cttgaagcgc ttgccatgct ggctgacctc tttgacacaa cctgcgatga 2270521 acttttaggc cgcgagaaac aaaagcagac tgctcctcag gccatagaat tggccacgtg 2270581 gagcagcctc gactttacca tttctgttga tggccagccg ctgagtgaag atgaaatcat 2270641 ccagctgatt acctttatac gcacaaaaag aaaagtacag gaggaactga gttaatcttt 2270701 agctcacggt ttaattttac cgtaggttcc tcctcctccg gctttcaatt ccagttttcc 2270761 ggatctcgct tttacgataa gcgccgcggt tttcggcggg acaacgcgag ccaaatcttc 2270821 ttctgcagcc tcatgaagaa cagccatttc tgttccgaag gcttttttta gtttgtccag 2270881 cgttttcggg cctacacccg gaacaaattg cagcgggatc tgatgtacat atcgcggacg 2270941 cgggacgcga acttcaagct gatcactcaa ttcacgcaat ctatcgctga ctcccttggt 2271001 aaatctggct tttccgcaat tcgcgcacgc tgtttccccg cttacagcag gctctccgca 2271061 cgcttcgcaa gccgtctgat aatatttccc caataacggg tccaagccat aatttgcgat 2271121 aattttcctg tcatcttgtc cctttaatgc aagagcaaat tcagtaaaat cagctgactg 2271181 cacatataat tcattatatt ctctgccgat tttccccaac gaatgcgcat cagaatttgt 2271241 taaaaaagga tacggattca attgcgatac gtgtgatgcc atgtctgtat cacagcttaa 2271301 tccaagctcc accgcgtcta tcatagatgg atcaaaaacc tcagttaagc ttgatttaac 2271361 cccttttcca tataagcttt tatgcggcgt aaagatatgg gcggggataa acaggccgcc 2271421 catatcctgc actttttttt gcaggtttaa gcccgtttca taaatccgct gcgagcttaa 2271481 atgaatattt ttcagccggg ctgacagcca gtttgaaaac tgtttcatat cagccagcgt 2271541 cggcataaat acgagcacat ggatcggtcc gctgcaggct tcatcataaa tctccagctc 2271601 gctccccaat aaaagagtcg tgctgcgata acggattcct cccccgtcaa gctcgcgata 2271661 ttttccagat gaaatgcctt cctcaagctc tagaatgact tccggagaat gacagtcgat 2271721 aatgccgagg agttcaattc ctttatgttc actggcttca accaaaattc tgtccagcgt 2271781 taatgttttg gcgcctgtta ttttgacagc ccttcctgta aaggtccggc cgatatgaat 2271841 gtgcaaatcc gcgtaaatct ttttcatttt tgtgcttgga gcgcttcttt cagctgaaga 2271901 tactgaatcg cgtaggctgt tttagcatca tatacttcac gcgattcaac cagctttagc 2271961 gcatcttcaa gcgtcacctc catcacttca acaaactcgt cctcatcaag ctcccgtttt 2272021 tcttcaagca cagaaagctc ctcagcaaga aaaacgtgaa cgatttcatc tgcaaatccg 2272081 ggtgatgtat aaaacgcagt tatttttgtc agtttttttg ctgtataacc ggtttcctct 2272141 tcaagttccc gaagtgccgt atactccggc tcctcacctt tttcaagctt accggccgga 2272201 atttcaacga tcgtccgctc aagcggctta cggaattgtt tgaccatgat gattttccct 2272261 tcatctgtga cggctagtac cgctacagct ccagggtgtt tcacaatttc acgtttactg 2272321 gctttgccgt ttggcagctc tacatcctcg acataaagat caatgacttt acccgaaaaa 2272381 atctgttctt tggcaattgt tttttcttct aatgatttca tttcttcatc tcccgttctg 2272441 tctctatatg atgccccata cattttatca tactagagca aaagggggct tcttcgtgaa 2272501 agtgcaccgc atgccaaaag gtgttgtctt agtcggaaaa gcatgggaaa ttcgagcgaa 2272561 gttaaaagag tatggacgca catttcaata tgtgaaagat tggatctcaa agccataaaa 2272621 gttgaaactt tagctccttt atattacggt caatacaaag cctaaaaaag gagtgtgcac 2272681 atgagaaagc gcaaattggg tacatctgat ttagacatta gcgaagtcgg actcggctgt 2272741 atgtctcttg gaactgaaaa aaacaaagca ttgtccattc tggatgaagc gatcgagctt 2272801 ggcatcaact atttggacac agcggatttg tatgaccggg gacgcaatga agaaattgtc 2272861 ggtgatgcga tccaaaacag acgccatgat attattctgg caacaaaagc gggaaaccgt 2272921 tgggatgacg gaagcgaggg ctggtattgg gacccttcaa aagcttacat aaaagaggcg 2272981 gtaaaaaaga gccttacacg tctgaaaaca gattatatcg acctttatca gctccacggc 2273041 ggcacgatag aggacaacat tgatgaaacg attgaagcgt ttgaggaatt aaaacaagaa 2273101 ggtgtcatcc gctactacgg catttcttcc atccgcccga atgtgattaa agaatatgta 2273161 aaaaaatcaa acatcgtcag cattatgatg caattcagcc tgtttgacag acgccctgag 2273221 gaatggctcc cgcttttaga ggaacatcaa atcagcgtag tcgccagagg tcctgttgcc 2273281 aaagggctct taactgaaaa accgcttgat caagcttcag aaagtatgaa acaaaacggg 2273341 tacttgtcct attcattcga ggaactgaca aatgcccgta aggcaatgga ggaagtggct 2273401 cccgatcttt ccatgacaga aaagtcgctg cagtatctgc tagcacagcc ggctgtcgct 2273461 tcagtgatta caggcgccag taagattgag cagttacggg aaaatattca ggcagcaaat 2273521 gcacggcgtt taaccgaaga ggaaatcaaa gcgctccaat ctcatacgaa acaagacatt 2273581 tacaaagctc atcgctcata gcagaaaaac cagcacctgt acgggtgctg gtttatttat 2273641 attgatgcca atccatttgg ctttcattta ggagttcttc aaagctctta tttttttcga 2273701 tctctttttt ctttctaatc tgttctgctt tttctctttt ctgcctcttt tcatcctctt 2273761 ccttcaattg gctcttcatc tccataagct ttgctttgat atcggattga aggccgtctt 2273821 ttagctggtg tttgtcaatg gatttttgtt ttttcatgca gacttccccc atgttttgtt 2273881 ttgaagccag tttatcacgg agcatataaa ctgaacaagc agactctctt ctgatcactt 2273941 tctcagcgta gcagtgttta ggtataatga tcttaaacac gaattgccta tatatttcgt 2274001 tgaaaggtgc tgtgactttt gaagaaaatc cttttggcca ttggcgcgct cgtaacagct 2274061 gtcatcgcaa tcggaattgt tttttcacat atgattctat tcatcaagaa aaaaacggat 2274121 gaagacatta tcaaaagaga gacagacaac ggacatgatg tgtttgaatc atttgaacaa 2274181 atggagaaaa ccgcttttgt gataccctcc gcttacgggt acgacataaa aggataccat 2274241 gtcgcaccgc atgacacacc aaataccatc atcatctgcc acggggtgac gatgaatgta 2274301 ctgaattctc ttaagtatat gcatttattt ctagatctcg gctggaatgt gctcatttat 2274361 gaccatcgcc ggcatggcca aagcggcgga aagacgacca gctacgggtt ttacgaaaag 2274421 gatgatctca ataaggttgt cagcttgctc aaaaacaaaa caaatcatcg cggattgatc 2274481 ggaattcatg gtgagtcgat gggggccgtg accgccctgc tttatgctgg tgcacactgc 2274541 agcgatggcg ctgattttta tattgccgat tgtccgttcg catgttttga tgaacagctt 2274601 gcctatcggc tgagagcgga atacaggctc ccgtcttggc ccctgcttcc tatcgccgac 2274661 ttctttttga agctgagggg aggctatcgc gcacgtgaag tatctccgct tgctgtcatt 2274721 gataaaattg aaaagccggt cctctttatt cacagtaagg atgatgacta cattcctgtt 2274781 tcttcaaccg agcggcttta tgaaaagaaa cgcggtccga aagcgctgta cattgccgag 2274841 aacggtgaac acgccatgtc atataccaaa aatcggcata cgtaccgaaa aacagtgcag 2274901 gagtttttag acaacatgaa tgattcaaca gaataaaaaa gcgaaaggcc tcttcggctc 2274961 tttcgctttt ttatgttaca gaacgtcggt aatgccatcc atattttctc tgatccattc 2275021 aatcgcaaga tctatcgttg taaactcctg cgtctcgaag gtcatttcat cctgcaatag 2275081 ccagacatct ttcttgatgg actctgctcc tccgattgac cagtgaagca aggtataagg 2275141 atggttttga ttcaggaagg atacccacgt tttattttgt gctgtgttct tcattgcctt 2275201 cagcttttgt tccacgtttc gcgtctccta ctttactaat atgctcattc tggggctgag 2275261 catttcagcc gggcttttca gcgccaatgt tttggctttt tcattgtaat cgatcgtcat 2275321 ttgatcgtca aaaaacactt tttgcgacga ttggatatac agcggaatgc cgttcgtttc 2275381 cagctgctcg cactgtcccg ttaattcttc tgccagccag attgtcggga caccgcttac 2275441 cgcgcagccg catccttctg catcgtaacg aagctgggct ttttttcccg ggttggcgtc 2275501 aaacgcctgc tgcagtgcct gttttgctgc atctgtcaca tgtatgttca taaggtgaaa 2275561 cccccgtttt catcattttc gctattgtag catacaatac tgccattcgc attgtttctg 2275621 ccttttttcc accgcttcgc attttcttct gcagtcttga tccactcatc tttcccttgt 2275681 atatactgat tgatgctgtc agggtgctgg gccgccagct gttttttgag aacggcgtat 2275741 tctttcgcta tgtttggatg agctctgaga taatctctga ataacagatg cctttcaata 2275801 gcagggtttc cctgttcgta catatggaca tgatgagtgc gtttatttcc gcccttttgg 2275861 aaataacgcc tgcccgctat accgttctca ccttttggtg tatagccgtt ggccttcatt 2275921 tgttcatcaa attggctcac ggcttcaatg cttctgactt caattaacat atcaatgatt 2275981 ggcttcgctg ccatgttagg tattgatgtg cttccgatgt gatgaatagc gataatctcc 2276041 ggcccgaaca caagtttcag ccgttctttt tcttcatcga aacattctgc ccatttttcg 2276101 ttgtagagaa tgatctcaac ttttcttttc ggatacaaat gaaagaccga cagcaataga 2276161 ccctgcgctg ctttgacggt ttctgccttt tggaatccgg cctgtgtata gagtgacaca 2276221 gccggggtat tgttctcggc tgtgactact tcgattttct cagcgtcttc attatgatca 2276281 atgacaaatt gcagaagcgc tcgtccaatt ccttttctga aaccgtcagg atgcacaaca 2276341 agcctgcaaa tggtgagata atgcatgttt ttctcatatg aaatgacacc gatcagcttg 2276401 ccgtttttcc gatatcccgc aaaccgttca tgggatgctt gaatatcctt taccttctct 2276461 tgtaaagcgg gaataccgtc aaaaccgata atctctgttt cctttatgta ggcggggatc 2276521 tgtacggcta aaatctcacg cgctatagtg gcttccttat gctggagaaa ttcaatcatt 2276581 cgtgttctcc tgaaacagcc gctgtctgtc gacttttgcg acgcggactg catacgactc 2276641 gtaccaaacg cttcttcctt tttcttttgc tgcttgatgt tcagtgtgat gcctccaatg 2276701 gttaattgcg tccatactgt cccaatagga aactgtgatg ccccttccat ccgcttcacg 2276761 tacgctttcc acgcctaaaa atccaggctg atccgccgca agtgatacca tccgctccgc 2276821 tgtttctcca tatcctgtgt cattttcgct tttgacagaa gaaaaaatga ctgcatagta 2276881 aggaggctca ggtgtttttg ataaaaaatc catcatattt ccccctcata tgtttttgac 2276941 aaatagtacc ctgtcttggc ccgggccatc atagtttgca aacactgaga tgccatttac 2277001 cgttttggtg cccttttcaa tatcaaaccc caattttgtg tgatatgcga ttgatacctt 2277061 attcacaggt gaagtgacac acttcacccg ggtgcagccc ctttgtttta ctgtttcgat 2277121 aaatacatca tacaattgtt tcccaatttg catttttctg aaatccggat gcacaccgga 2277181 aaaatgaatg tacgccgttt caggatcgga ttgcgattga aatccgatta aaaatcccgt 2277241 catgctgtta tgttcggatg taataaagct tgtgtcctga aaatgctcaa aaaatagtct 2277301 cggcaatttt tctttcagct gtctgccgcc ccaccattca ttcagtacag acgttaccat 2277361 ttcataatct gaagacgtga ttgttcgaat atccattacg atttgatctc cctccgtctg 2277421 gcaaaacgaa tgtcagctct ttttctcaca atataaaaat tatattttgc ctggctggaa 2277481 ttgtaaatgc cttctttcct gtatcatacg tttccagact gccgagggaa caatgtttga 2277541 tcattttacg cctatttctc ccccaaacag gaggagagac tttacagcac aatatcaagc 2277601 acttgatcaa gtttcagctt ataaagctga tcctcgtctc cttttatcca tactgctttt 2277661 tcaaactctt cataccggca gattttcccg gtgcagcaga caatctcacc gtcctgaaag 2277721 cagctgacag tgatatcctg agcaaactcc atcgcggcgc aaagcgtttg attcatctct 2277781 tccagcttat cggggtcaag gatcggcttt tgcagcttct gtttaagtcg ctttctctcc 2277841 agcaggcttt gcttatgttc cggcagaaac atcctgctcc cttcccacag caggttgccc 2277901 ctttttaaat ggtcgttcat ttataatgcc cccctatttt agccgcacgt tcaaatgcct 2277961 ggcctgccgc tgtcagtgac gccgccctga tgattgctgt atcgccgaat cgatttttaa 2278021 tgccatccat cacatagcct aggctcattt tctttgcata atcctgaaat aaattgagct 2278081 gccatatgtc atcagatgag agctgagaca gattgacacc gaggcggcgg acgggtttcc 2278141 cgtcccaaaa tgtaagaaac agccgtcgta cagcctcata tacatcctgc gtagaattag 2278201 tcggctctgc cagcttcact tgccggttga agcccgtcgg ccaatcaaaa tcagcacccc 2278261 ggcagctcac tgacactgtc tgccccatga ccccggcgtt tcggcttcgc ctgcacacct 2278321 cttcactcag ctcaagcaat acgaccttga tttctttgtc aaagtgttcg tagtctctcg 2278381 ggagagtcat tccatgacct atcgcctttt gcccgtccag agacgaagtt gacacagggg 2278441 aatagtcgat tccgtttgcc gtcatccaca gcacgtggcc gttaatgccc catttctttt 2278501 ttaaaagatc gagcggaaaa gccgcgagcc cgccgatcgt gctgatgccc attcgattta 2278561 aatgatgctt catgcggctc ccgacgccaa acatgctgcc caccgggagc ggccacattt 2278621 cggttttcat attttctttc gttaaggtaa aaataccgtt cttattcttt ttggcaaaat 2278681 tgtcacacgc aattttggcc agcgctttgt tagggccgat tccgacccgt gcataaacgc 2278741 cgatctcccg catgattctg ccctgaatgc ttttcgcgat ctccatcggc gtcccaaaca 2278801 gcttctggct gcctgtaatg tccatgaact gttcatcgat ggaatacggc tccacaaggt 2278861 ctgtatactc ctcgagaatg gccgtaattt gcagtgatac atcaatatac cgctgcatac 2278921 gcggccggag cacaacagcc tcaggacact tttcctgcgc ctcccacagc cgtgaagcat 2278981 tcaccacacc cttttgtttc gccagcgggc aggcagccaa tacgactccg cccctttttt 2279041 cagggtcacc cgaaacaatg acgggcctat ttttcaaatg tggattttcc gctttctcta 2279101 cagatgcata aaacgattgc atgtcaacga gaaaaatcac tttttctttc atcatacaca 2279161 cctctaaaaa gaacttatgt tcgcttttca ttatatgcga aagtatgttc gttttatact 2279221 ggtaaatgat tcttgtctga cagaaaatat gatccaaggg tttgagagaa gaaaaacatt 2279281 tagtagaata aaagcgaagc ataaggatag gagagtcatg atggagaaat ttgtcgaaaa 2279341 aatgctggga caggcattgc ggcaatacgg cagaaacgtt gctatagatc cgttaagccc 2279401 gtatgaaaaa caaagcctga aagcggctct acaagagaga cggaatgaag aaccagatga 2279461 ggatttgcat gcgcatatag aagatatcat ttatgactat gtcacaaacc aaggcctgtt 2279521 ctcttaaacg catgactgtc agttctttca gccgctgatg cggcttccct ttgaaaacac 2279581 cgcctgaaac aaataaacag tctcaggctt acagaaaaaa agcaggattt tctcacgctc 2279641 catagattca tatggcctgg cgtaaaattc ccctcaatgc tcgcgcaaaa cggaataagc 2279701 tgtccatgat cacgcgtata cactttttcg aagagatgtg ctctcttgtt ctgtcatgcg 2279761 gtccatgccg gttttcagcg tacatcttga tctcatagcc ggtttcactg ccgatatgat 2279821 ccacgttctg gcggcttaaa ctaacacacc ctcactgacc aatcgctttg cttttcatcg 2279881 gacatcccgt cattttcctt ctttcaagat gtaaactccg tcagccacac gcatcctcaa 2279941 cgcatagtat attgccatcc atacaatcag gcatactaca tgtcaataac gaaatatttt 2280001 gaacgatcta ttggagaagg aaattttttc atatatgata gagaaagatc atacatacag 2280061 gagagaatat aattcatgaa gaaatggaaa gatatccacc cgatcagctg gacaattata 2280121 atcggaacca ttttcggcag aatggcaaca tcgatgagca ttcctttttt agcgatttat 2280181 ttgacagccg tccaaggcgc atcagcttcc tatgcagggc tggtcatcgc cgcgagctca 2280241 tcagtcggca tcctcgcaag cttttacggc ggatatatct cagataaatt cggcagaaaa 2280301 aacatgatgc ttgtatcgat tttcggatgg atgctggtat ttgcaggctt tgcggcagca 2280361 tctaatctct gggtgttttt tgtagtaaac gcattaaacg gtctttgcaa atcactgttt 2280421 gagcccgctt caaaggcctt gttgtctgat atgacagaag aaaaaacgag actgctagtt 2280481 tttaatttac gctatgcggc tattaatatc ggcgttgtct tcggacctgt gcttggccta 2280541 tatttcggct catcgcaatc gactacgccc tttttggtgc ctgcagtcat ttacggacta 2280601 tacggaattg tgcttgccct ccaatttaaa aaacatccat ccttatcagc accagcccag 2280661 tcccgaaata tgagcgtgcg ggaagcgttt atggtcacgc aaaaggatta tctttttacc 2280721 attgctttgg tcggcattac gctatgcacc ttcggctact cacaattcag ttccacattc 2280781 cctcagtata tggcgcagaa ccccttgatc ggcaatggaa cgaagctgta tgggctgatg 2280841 ctgacattaa acgcaatcgt tgtgttggcg acgcaatttc ccattgtcca ttttgcaaaa 2280901 cggttttcgc cgctttgttc tctgatgctc ggtaatgtga tggttagcat cagcatggcc 2280961 attttcaccg tatcacacgg tgttccatca attgtgatga ttgtcatcac atttacaatc 2281021 ggcgaagtgc ttttattctc tatgatggat ttgtatgtag accagattgc aaaaccagga 2281081 ttaaaaggca cttatttcgg ggcaatcggt ttttcacagc tcggaaacgt catcggccct 2281141 tgggtcgggg ggatatgtat agacctgttt ggcgctggcc ggccgattta tattttttct 2281201 gtcctgagcg gcattaccct gctcggcctg ccatttttag cgttcgccta tcggcaaatg 2281261 aaaatggaga ccacaaaaca ccgttcccgt ctggaaaagc cgctttaaat aaaaaacgga 2281321 agagaatgaa tctctcccgc aaacatgagg tgaagaacat gaatataggt gatgtgatgt 2281381 ttcagctgtt tgtatttatt atatttgccg ctgtcgtctt tgcggctgtt acaggcttca 2281441 agtatgcgaa aaaccgaaaa gcgcagctgg atcgcattga gaaaaagctg aacagcctgt 2281501 ccgaagatca cgattaacag cttggggcaa cgagctctac cttaatccgg tctggatcct 2281561 cacaaaagac tgcataatgc ccgtctcctc cggcaaaagg atgcctgtct cggtacaaca 2281621 cacgatagcc ttttgccgtc aatttttcag tcatctgatc gacttgaagc ttggattcag 2281681 catgaaatgc gagatggttc agaccgactc ggcatctatg gtattccggc tctagaaatg 2281741 gctctttcgc ctgcacaatc actaggtaaa aacgatcttt cttccagctg atgcctgagc 2281801 tccatttttg atactcttta taaccaagtt cttttaagaa ccagccccaa aaccgcctag 2281861 acgcctccaa atcagagaca tacagttcaa tatgatgcac atttcatacc ctccttacca 2281921 acacttcctc gaccttatgc ccgtctccct tacgcaaaat gagatctgac ctgaatttag 2281981 ttggcaaaat attttcatat aaattcggcc ggttgacact ctcccaaatc gaggctgcca 2282041 tctcgtcagc ctcctgatcg gacaagtctt taaatttatg aaaatatgaa tcaggatttt 2282101 gaaaagctgt ttcccgaagc aggcgaaaac gctctaaata ccaagtgaaa atccggcttt 2282161 cctccgcatc cacataaatc gaaaaatcaa agaaatcgga aacaaaaata cgcgggtttt 2282221 cccggtcatc ctccaaggtg ggcgactgaa gaacattaat gccttcaata atcacaatat 2282281 ccgcctgttc tacaacctcg aacacacctt cctcgcggtc ataggttaga tgggaataca 2282341 ccggggcctt tacgctgtcc tttcctgatt ttaagtcatt caaaaattcg agcagcgcct 2282401 ttacatcata gctttcagga aatccttttc ttgacatcat atttttcttt ttcagctcgg 2282461 cagtaggaaa taaaaaacca tctgtcgtga taaggctcac ttttggacgg tcaggcaaac 2282521 gcgaaagcag cttctgcaag atccgcgccg tcgtgctttt tccgactgcg acactgccgg 2282581 caatgccgat aataaacgga attttggctg aatgtgggtg cttcaaaaaa acattgacat 2282641 gcttattgcg ttcagccgca gacttgacat gtaaatgaag caagcgaaca agcggaatat 2282701 agatcgtctc cacttcttca acagatagat aatcattcaa tccttccaca gcttttgcct 2282761 cttcttcaga tacagcaatc gacaaatgcc ccccaaaacc agaccaagac tcccgattgt 2282821 gctgtgtata taaagtatgt aggttaagtt ctttattttt cactgtttac acctgactct 2282881 ctgtaggtta aaacccttac aaagattgta acggaaaacc ttttcactgt ctgcttattt 2282941 ttcatttcgt ttttttagca aatcagcacc gattcggtta tacgcagcca tttcatcttt 2283001 tggaaccatg cttcctcccg ttccccagac gacatgtacg gcatgttcca tcttatattt 2283061 ctgagcatag cgccttccct cttctgtcga aaaaagctga accggcccga acatgccagc 2283121 aagagcagag ggctctaaat atttatcttc agatacagcc agcatatgaa gcaaagtata 2283181 aagcgtattg tcctctaccg tataacagcc gctcagaagc ggttcaatca gcttgccgac 2283241 aaatcctgac ggcctcccta cggcaagtcc gtcagcagcc gtctgattat ccaggccgat 2283301 atcctggacg gagatcttct cgtgaagtcc tgaataaagc cctaacagca tacaaggtga 2283361 atgagttggt tctgcgaaaa acacatgaac atcatctccg tataaaagct tcagcccaaa 2283421 tgctacaccg cccggtcctc cgccgactcc gcacggcaga tacacaaaca agggcgtctc 2283481 aagacttggc tttatattca tacagtcaag ctgtgttttt aatcggcttg cagcaacagc 2283541 atatcctaag aacagctgac gagaatgttc atcatcaata aaataacaga atggatcttg 2283601 ttccgcctgc cgtctccctt cgttcaccgc ttcactgtaa tctgtttcgt actccataac 2283661 agtgactccc ttttggcgga ggagatcctt tttccactgc ttagcatcgg cggacatatg 2283721 cactgtcacg cgaaacccga gtgccgcgcc gatgatgccg atgcttaaac ctagatttcc 2283781 tgtcgaaccg acagcaatcg aatagcggga gaaaaacccg gtaaaccgct cttcctgtaa 2283841 gatgcggtaa tcatcggttt cctgaagcat tccttcttga agcgcgagat tttcagcata 2283901 ctttaacact tcataaatcc cgcccctcgc tttaatcgat cctgaaatcg gaagctcatg 2283961 gtcgcacttt aaaagccatc ttccgggaaa tggctgctga tatgccgctt ccagctttcc 2284021 cttcatatgc tgcacctcaa aaagcggaga ctcgatgatt cctttagcgc ctttcgtctc 2284081 aggaaacacc tcggcaatgt aaggtgcaaa ccgctgcatt cttttttccg cttccgctat 2284141 ctcggttgcc cactcatctg cacggggtaa tggcccctct ttcttgcctg aatttgccca 2284201 gaatacaggc tctgcatcaa tcagtttctg aataaacgga tctttaagca gagcatgaag 2284261 gacttctgaa tgaactgaca ttcaacaatc tctcccttcc actatcaaaa actgccccgt 2284321 gagaaacaag ccactccacc acaggcagtt ctatcattat tttttcatga gcgcgcgtcc 2284381 tgccagcttt tctacaagag ctggaaacag ctgatacagc ttagtgccgg cattcattaa 2284441 acgcggaaga ttgatctccc gctttttcgt aaaaattgca gctgtaattt gagctgccac 2284501 gtcatcagga tcaagcatcc agcggccgac atttttggcg tagtccccgc ctttatcagc 2284561 aatggaaaaa aagtccgtct gaatcgggcc cgggttgact gttgtcacat aaatgccggt 2284621 tcccgaaagc tccatccgca aagcgtttga gtaacctaac acggcatgtt tggtcgcgga 2284681 atacaggcta gacttcggtg tggcgatttt ccccgcttga gaggcgatat tgatgatatg 2284741 tccctttttt tgctcaagca tttgcggaag caccgctttt gtacaggcga tcaggccgaa 2284801 gacattcaca tcaaacatcg ctttcatgtc atccaatgta gagtctaaaa ccgtttcaaa 2284861 tataccgaag cctgcattgt taatcagtac atcaatcgag ccgatctgat cgcggacccg 2284921 ggcgatatcc tctaggcggc cgacatccag aggaaaaatc tcacactgtc cgctccattc 2284981 ctcggttatt ttccttttga tttctatcaa acgatcctcg cgtctagccg acagcaggac 2285041 atgggctcct tcagccgcgc ataagtatgc gattctttct ccaagccctc ctgaagcgcc 2285101 ggttatccaa atcctttttc ccgctatatg tttcacccat ttcacctctt cattgtttta 2285161 aagtatacgg tatttccttc ccaatatgac gtgatggctt cttcagcctc caacacatca 2285221 aggtgacctg ccgtttctga catcgttaaa aacaattcct tttcatatac agcaggaaaa 2285281 agctgctgac agacctgaaa agcggtcatc ggcttttcat ccagcatgcg acgcacatcc 2285341 tccgtcctgt tcctctgctt gtcaaaacgc ttctcaatca gcgcttgtac actggtgata 2285401 ggctcgccgt gaccaggaaa tacgattgtt ggatcaagtt gagacagcct tcgcaatgac 2285461 cgctgataat ccactaaagg ctttgacctg acgtctcccg ctttcggcgc ttccaaaatc 2285521 ggattagacg agctgtttgc cagcagtaga tcgccgccaa gcatccttcc gcttttttca 2285581 tggaacagaa caatatgcga ttcagcatgt ccaggcatct ccaacacaga ccagccctca 2285641 agcccatcta tgcccatacc ttctctgatt gattttgtca gagatctcgt acaggaaaat 2285701 gcgtacgctg atcgaatcag cttttccgcc ttccccgtat caaatggaac gcctaattca 2285761 ggcagcagct tttgaaaaaa acgtttttgc caatccataa aggcttgatt ttggctgata 2285821 taaggttcgt tgaatgtatg cccaatcact tcgatttcat ctgaaaagac atcaagcaag 2285881 cctgcatgat cagcatgatg gtgagtcagt acaacctgct cgatatctga caatttcaca 2285941 tttacagcgg caagctgctc ttgtaaggct ctggcagcct cttttgtatt cggcccggca 2286001 tcgataagtg tcagcgcatc accttttacg aggtaaacga taacatcgcc gacagcaaac 2286061 ggtgtcggga cgcggatcgc aattacatct tcagttgtca tcctttcgct ccttgtcttc 2286121 attcattatt catattttag ctttttctcg gtcttgtgtc attattgcag aatgagaaca 2286181 aacctttttg aaaaagctat tgacattagc ttgtccgcca ttgcataatg aacaacaaac 2286241 taaaacgaga accattggaa cgctatgacg aggaatagta tacaaggcaa tggcctaaga 2286301 gagcgatacc cccggctgaa aggtgttgcg gcccgcttgt ttgtagaacc tgccctcaag 2286361 tcgcggttag gaaaacctaa acgtttcccg cgttacgggg atttgagctg agcacaattt 2286421 gtgctaatga gggtggtacc gcgaaccttt tcgtccttta cgtgatgaaa aggttttttg 2286481 ttgttctaat agaaggagga tatcaatgaa aaagatagga tttgtcggcg ccgggtcaat 2286541 ggcagaagca atgatcaacg gcattttgca aagcggcatc acaaaaccag aacatatcta 2286601 tattacaaat cgctcaaatg acgagcgtct gattgaatta aaggaaacgt acagcgtgcg 2286661 tccatgcaga gataaaaatg agtttttcac tcacaccgat atcattatcc tcgctttcaa 2286721 accgaaagac gcggcggaaa gcatcgacag catccggccg tatatcaagg accagcttgt 2286781 catttcagta cttgcaggcc ttaccatcga aaccattcag cattattttg gcagaaagct 2286841 cgcggtcatt cgcgtcatgc ctaatacatc agcggcaatc agaaaatcag caaccggatt 2286901 ttccgtaagc acggaagcaa gcaagaatga tattattgcc gcaaaagctc tattggaaac 2286961 aatcggtgat gcaacactgg ttgaggagcg gcatcttgac gctgtcactg caatcgcagg 2287021 cagcggcccg gcctatgtgt atcgttatat tgaggcgatg gaaaaagcag cacaaaaagt 2287081 aggattagat aaagaaacgg caaaagcact cattttgcag acaatggcag gggcaacaga 2287141 tatgctcctc caaagcggca aacagccgga aaagctgcgt aaagaaatca ccagtcctgg 2287201 gggcactaca gaggcaggtc ttcgcgcttt acaggactcc cgctttgaag aagcaattat 2287261 tcactgtatt gaagaaacag ctaaacggag cgcagaaatc aaagaacagt ttgccggtgc 2287321 cgccttagag agacattctt agatgtaagg acaaaaacag aaggcacagt gccttctgtt 2287381 ttttattttt cccgcagcag ctggccggca gattctgatt gctttaatag cgcggagatc 2287441 gtaaatgaaa gcaaatcggg aagcacttca aaggaataag gcatatacaa tctttccgtc 2287501 catttatgcg ggtctttacc agccggaccg acatttaaaa ctgggacata taaagcctga 2287561 tttttaccgc ttggcaatga ataccctctg ttaaagagcg gcatattgct tgtgtatgca 2287621 tcaacctcct gtttttccag ctgaagataa ctcaagtccg aaagtccggg gaagtactga 2287681 acctcccgta atgcaatgcc gtatcgctca gccgcataat gctttatctg atctgctgta 2287741 tttctgatca attgatcatc ctttgaagaa acagctggat aaagcggcgg actataaaac 2287801 agaacgatga gcggcgcatc ctccttacaa agcgaagcaa gctcagaaac aattttcgtc 2287861 gaaaaatccc tgtctccaag ctcccccctg ttagcaaagg cataatttag agcccgctct 2287921 gtttccgaga tccccgcacg cttttttgca cgcgagacca gctcatcaaa tgtcaaaaca 2287981 gtgacgtccc gctcaatcgg ctgaaatggc tcaaattgtt gaaaatcctg tgttttcttc 2288041 cgaacgttcg acatgatttc ctccgccgcc tgttctgctg ttttaagcag catctgatgc 2288101 agctcactag ctgagcgttt cattgacagc acattaaata atgtgacggc tgtatgcggt 2288161 gtctggactg aatatgcctc tttcaagtcc ttttgcatta agtttaccgg cggcggagtg 2288221 acctcgccat caaccttttc gcaataatca gcattcagtt caagcaaacg gttaatctca 2288281 gataccatta aatttgcgtt tagacctgaa aacggctctc caacatgtgt ctcaatcccc 2288341 ttgcagaaaa aacccgcaag caccttgcca atgcttcctg tataaaaata ttgctgctga 2288401 tcgccgggaa atttttcaaa catcggttcg gcattcaggc aagcggttaa tgtgatatca 2288461 tgctttttct ccatctcctt caatgcagga accgcttcaa tcatgcctct tgaattcact 2288521 tcctcgtccg gaaccgttat caacagcaga ttgccctcaa aatgcccgtt cattgccctc 2288581 tccagcatcg acagttgaat acaaagcccc gctttcatat ccatcgtccc tcttccgaac 2288641 agccagtctc cgctttcggc atctcttctc acacgttccg ggagcagctc ttttttctct 2288701 aaaaaggagc tcaaaagctc agcaggcttg caagccatat gtttaaattc gccgtaatct 2288761 tctatgtcaa cgacatcaaa atgactcagc agaagcactg tctttttgac attcttcttt 2288821 ttgactagag ccgtaagaaa agatctgcca tcgtccatcg gatgaagtgt tacatcatca 2288881 gggtgctttt gaaaataggg cttgtccttc aaaataaaat aaagatactc tgcaagcgct 2288941 acctcgccct ttgaaccggt gatgctttcg tattgcacaa gagaagttaa aagtgccagc 2289001 aattcgtcct tcgtctgcca attcattgat tccgcccctc ctatgaataa aaatgcttct 2289061 atactgaaaa ataaactgat ttctcgtcta ttatacagaa atgtttgaca aaagcggttc 2289121 atttgagcag tttatatgac gggaaagaaa tgacttgata taatcaatct ctaaaaacct 2289181 tacgggaggc gaaagaaatg gccagaaaat tatttacacc tattacaatt aaagatatga 2289241 cgttaaaaaa ccgcattgtc atgtcgccaa tgtgcatgta ttcttctcat gaaaaggacg 2289301 gaaaattaac accgttccac atggcacatt acatatcgcg cgcaatcggc caggtcggac 2289361 tgattattgt agaggcgtca gcggttaacc ctcaaggacg aatcactgac caagacttag 2289421 gcatttggag cgacgagcat attgaaggct ttgcaaaact gactgagcag gtcaaagaac 2289481 aaggttcaaa aatcggcatt cagcttgccc atgccggacg taaagctgag cttgaaggag 2289541 atatcttcgc tccatcggcg attgcgtttg acgaacaatc agcaacacct gtagaaatgt 2289601 cagcagaaaa agtaaaagaa acggtccagg agttcaagca agcggctgcc cgcgcaaaag 2289661 aagccggctt tgatgtgatt gaaattcatg cggcgcacgg atatttaatt catgaatttt 2289721 tgtctccgct ttccaaccat cgaacagatg aatatggcgg ctcacctgaa aaccgctatc 2289781 gtttcttgag agagatcatt gatgaagtca aacaagtatg ggacggtcct ttatttgtcc 2289841 gtgtatctgc ttctgactac actgataaag gcttagacat tgccgatcac atcggttttg 2289901 caaaatggat gaaggagcag ggtgttgact taattgactg cagctcaggc gcccttgttc 2289961 acgcagacat taacgtattc cctggctatc aggtcagctt cgctgagaaa atccgtgaac 2290021 aggcggacat ggctactggt gccgtcggca tgattacaga cggttcaatg gctgaagaaa 2290081 ttctgcaaaa cggacgtgcc gacctcatct ttatcggcag agagcttttg cgggatccat 2290141 tttttgcaag aactgctgcg aaacagctca atacagagat tccggcccct gttcaatacg 2290201 aaagaggctg gtaatgccca taagagatat cctgtagagg atatctcttt ttttattttt 2290261 agagaaacga tcggctaagg ttctccgtct ccctagtaga accaattaga ggagatgact 2290321 ccaatgaaat cagcttggat ggaaaagaca tatacaattg acggatgtgc gtttcataca 2290381 cagcaccgga aaggatcaag cggtgtaacg attgtctttg aggccggcta tggtacttct 2290441 tctgagacgt ggaaaccatt aatggcggac attgatgatg aatttggcat tttcacatat 2290501 gatcgggcag gcataggaaa aagcgggcaa agcagagcta aacgaacagc tgatcaacaa 2290561 gtgaaagaat tggagagttt gcttaaagca gctgatgtaa aacctcctta tttggctgtt 2290621 tcacactcat acggagctgt catcaccggt ttatgggcct gcaaaaacaa gcatgatatt 2290681 atcggcatgg tccttcttga cccagcttta ggcgattgcg ccagctttac ctttataccc 2290741 gaagaaatgc acaaatcaca tacgagaaag atgatgcttg agggcacaca tgcagagttt 2290801 tcaaaaagtc tgcaggagct caaaaagcgg caagtccact taggaaacat gcctcttctt 2290861 gtgttgtcat caggagaacg gactgagaaa ttcgctgctg aacaggagtg gcaaaacttg 2290921 cacagcagca tattgtctct atctaaccaa agcggctgga ttcaagctaa aaacagctcc 2290981 cacaacatcc atcatgatga acctcatatc gttcacttgg ctatttatga cgtatggtgc 2291041 gcagcgtgcc agcaggccgc tcctctttac caggcagtca attaacgtaa aaaaagaccg 2291101 ggccgtaagg gattcccggt cttttatatt attttgtttc acggtgaagg gtatatttct 2291161 ttaaacgcgg tgaatatttt ttcagctcca aacggtctgg attggtgcgt ttattttttg 2291221 ttgtgatgta atttcggtct cccgtttcag tgcaaagcta aagtaacatt tactctcata 2291281 attaacatct ccttataaaa cgtaatgatt acgttttatt atacaacgtc atcacaaatt 2291341 gtcaaataag agctccgcct tcagcctcgc gggacgttta cctctaagaa atcatatgcc 2291401 gccacgctat tggggaaaac gtcaaccgct tctttttgaa gctccaaaga agcatctccc 2291461 tgatatcttg cgctgatatg ggttaaaatg agctgcttcg ctcttgcttc tttcgctgtt 2291521 acagccgctt gttccgttgt actgtgataa taatcataag caagtttacg gtcttcctta 2291581 gcaaaggttg cttcatgaac aagcacatca caatccctcg caagctcttt tagtttgtca 2291641 cttactctcg tatcaccgga gaacacaaca gatcttccct ttttaggagg ctccagaaaa 2291701 tcattcccat tgatgattcg tccgtcttca agcgttaccg tttcgccttt tttgattttc 2291761 tgatatacag gtccgggcgg gatgttcatt tcttttaata cgtcagcctt caaggaaccc 2291821 ggtacgtctt tttcctgcac acggtacccg aaggcttcca ctccatgaat aacagatacc 2291881 gctgtgacaa taaactgatc gtcctcaaac acgattcctt cttcaatttc ctggatcgca 2291941 agcggatatg tcaaatgggt tttcgtgacg gcaaggcttg tttcaataaa cgccttgatc 2292001 cctttaggtc cgtacactgt cagctcgtcc tctccgcctt gaaaggaacg gctccccaga 2292061 agccccggaa gtccgtatac atgatcgccg tgcatgtgtg taataaagat tttctctatt 2292121 ttacgaggtt taatcgttgt atgtaaaatt tgatgctgtg tggcttcccc gcagtcaaaa 2292181 agccataccg aacgcctttc ttcaagcaat tttaatgcca ccgacgttac atttctcgcc 2292241 ttggcgggga tgccggctcc cgtccctaaa aaaagtaatt ccacgtttcc ttcctcctac 2292301 tagaaccaga tacctacaag aatacaggat caagcggaaa atgtgaatct tgcctctgaa 2292361 aagaacaatc ctttcgtgct agaaacattt tttcagcatt ctgcttaaaa aagggcttaa 2292421 atgtttgctt tcgttgaatt ttagatttaa aatgaaggaa atatacgggg tgtactaaaa 2292481 taaagcttcg aataaagtga ggtactttta gtgaaaacaa accaacaacc aaaagcagta 2292541 attgtcatat tcggtgcaac tggagattta gcaaaacgaa aattgtatcc gtctattcac 2292601 cgtttatatc aaaacggaca aatcggagaa gagtttgcag tggtaggagt tggaagaaga 2292661 ccttggtcta atgaggatct tcgccaaact gttaaaacat ccatttcctc atctgcagat 2292721 aagcatatag atgatttcac gtctcatttt tactatcacc cgtttgacgt gacaaaccct 2292781 ggttcttatc aagagctaaa cgtattgctt aaccagctgg aagatacata tcaaattcct 2292841 aacaacagaa tgttctactt ggcaatggct cctgaattct tcggaacgat tgcaaaaaca 2292901 ttaaaatcag agggtgtaac agctacaacc ggctggtccc gccttgtcat cgaaaaaccg 2292961 ttcggccatg atctgccaag cgcacaggca ttgaataaag aaatccgcga agcatttacg 2293021 gaagatcaaa tttacagaat cgaccattat ctaggcaaac aaatggttca gaacattgaa 2293081 gtgattcgat ttgccaatgc gattttcgaa ccgctttgga caaaccgcta catttcaaac 2293141 attcaaatca catctagcga atcactaggc gttgaagacc gcgcaagata ttacgaaaaa 2293201 tcaggcgccc ttcgcgacat ggtgcaaaac catattatgc agatggttgc ccttcttgca 2293261 atggagccgc ctatcaaatt gaacacagaa gaaatccgca gcgagaaagt gaaggtgctg 2293321 agagcactgc gtcctattgc aaaagacgaa gtggatgaat actttgtgcg cggacaatat 2293381 catgctggtg aaattgacgg tgtaccggtt cctgcttata cagatgaaga taatgtcgct 2293441 cctgactcca atacagaaac ctttgttgcc ggcaagctct tgatcgacaa cttcagatgg 2293501 gctggtgttc cattctacat cagaaccgga aaacgaatga aagaaaagtc cacaaaaatt 2293561 gtcgttcaat ttaaggacat tccgatgaac ctgtactacg gtaatgaaaa caacatgaat 2293621 ccgaacttgc ttgtcattca tattcagcct gacgaaggca ttacgcttta cttaaatgct 2293681 aaaaagcttg gcggagcagc acacgcacag ccaatcaaac tcgattattg cagcaattgc 2293741 aatgacgagt tgaacacccc tgaagcatat gaaaaactaa ttcacgactg tcttcttggc 2293801 gatgcaacaa actttgcaca ctgggatgaa gttgcccttt cttggagctt tgtcgactct 2293861 atttctgaaa catgggcagc aaacaaaacc ttatctccta actacgaatc aggctcaatg 2293921 ggaccgaaag aatctgatga tcttttggtg aaagacggct tacactggtg gaacatataa 2293981 taagaagaaa aaagccgaaa tagtttacta agcattttcg gtctttttta cgctgaacaa 2294041 aggtataaca atctccttaa taacaaaacc cccaaagctt aagagcttcg ggggtttcta 2294101 ttgattactt catccattca gtatggaaga tgccttcttt gtcagtacgc tcataagtat 2294161 gagcgccaaa gtagtcgcgc tgtgcttgga ttaagtttgc aggcagtacg gctgtgcggt 2294221 agctgtcata gtaggctaat gcgcttgaga atgatggcac cggcacacct tgggcaactg 2294281 caagtgaaat cacttggcga agcgctcctt gatagctttc tacaatattc ttgaaatagc 2294341 tgtcaagaag caggttgtca agctcaggct cgcgatcgta agcttctttg atcttctgaa 2294401 ggaatgccgc gcgaatgatg caaccaccgc ggaagatcat agcgatttca ccatatttca 2294461 gatcccagtt gtattcttca gaagcagctt tcatttgggc aaatccttgc gcgtatgaac 2294521 agattttact catgaacaac gcttttctga ccgcttcaat cagctcttct ttattttctg 2294581 taacaggctt cacttctggt cctgaaagaa gtccgctcgc ttttacacgc tcttccttca 2294641 tagctgagat aaagcgtgcg aatacagatt cagtaataat cggaagcgga acgcctaagt 2294701 caagtgcgct ttggcttgtc cattttcctg ttcctttttg gcctgcttta tcaagaatca 2294761 catcaacaag cggtttgcct gtttcttcgt ctttttttgt gaagatgtca gccgtaatct 2294821 caatcaggta gctatcaagc tcacctttat tccattcagc gaaaacttca tgaagctcat 2294881 cagcagaaag gcccagcacc tgtttcagaa tgaaatatga ttcagagatc agctgcatat 2294941 ctccgtattc aattccgttg tgcaccattt ttacgtaatg gccggcgccg tccggaccga 2295001 tatatgtcgt acaaggttct ccgtcaactt ttgcagaaat ggcttcaaga atcggtttta 2295061 caagctcatg tgcttctttt tgtccgccag gcatgataga aggtccttta agcgctcctt 2295121 cttctccgcc ggaaacgcct gttccgataa aatgaatgcc gctttcagcg agttctttgt 2295181 tacggcgctg tgtatcttta tagtatgtat taccgccgtc aattaaaata tcatccttct 2295241 ctagatgagg aagaagagat tgaattgtcg catctgttgc agttcccgct ttaaccatta 2295301 ataagatttt gcgcggtgtt tccaaggatt ggacaaattc ttcaatgctg taagtgccaa 2295361 caacattttt tccttttgcc tcctgtaaaa actcctcagt tttactgctt gatctgttgt 2295421 aaacagaaac agaaaatccc cggctttcga tatttaaagc cagattttta cccatgaccg 2295481 caagtccgat aacgccgatt tgttgttttg acatattcta acgtcccttc tgcaaacgtt 2295541 taatcatttt aaaatttaaa ttaaaataaa atgatattta taataaagaa attaccatac 2295601 attcaccctt tttttcaagc gattcagctt ttcttttcat cttgaaaaaa atctttatta 2295661 aagcttgttc cctttgtttt gctctcctct ttttttaacg ttgccccttt tctgatcagt 2295721 ttggtaccgt actttttatt cagcttttcc atcatctgct gaatgggctc atccttcgca 2295781 tcttcattaa agctgaacaa atcgagctgt ttataggcct gctctttttc tactaaatcc 2295841 gttccggtaa tgccaagcag cctgacagga tttttattcc aatgtttaaa aaagaggtgc 2295901 tccgcttctt tcaaaatgtc atttttttga tcaatcgggt ttctcagcgt agtgcttctt 2295961 gtgatggttc tccaatccgc atatctaatc ataataaaaa gcttcgaagc catgacttcc 2296021 ttgcgctgta aacggtcact cacagaagcg gcaagctttc taaaaacgcc taacagctct 2296081 tcttcatcac tggaatcatg ggaaagtgtc gatgagttgc cgacgctttt aaattcgtaa 2296141 atgcgctccg ggtcaaccgg cgcatggtga atgccatttg ctttattttt aaggcgcgga 2296201 ccgttgatgc caagcaggcg cttcagcgag tgttcatcag ctgcagctag ctctccgatt 2296261 gtatggatgc cgagtccctt cagtttttcc gctgtctttt tgccgactcc gtgcatctct 2296321 ccaacaggaa gcggccacag gatatcgggc acttgcctct ttcttaagat cgtaattcca 2296381 agcggttttt tcatatcaga cgccatctta gcgagaaatt tattcggtgc aatccctatg 2296441 cttgacggga gcagcagctc tttttgcagc ctgctttgga tttcttttgc cgtctctaga 2296501 gcgcggctgc tgtatggtgt atcggtcatg tccatatagc cttcgtcgat ggagacaggc 2296561 tccactaggt cagtatattc acgaagaatg gtaaacatcg ctcgtgaaga gtttctatag 2296621 cggtcaaagt tcggcggaag aacgatgagc tcaggacaat ggcgcttcgc ttgccaaacc 2296681 ggcatcgttg ttttgacgcc gcgcgctctt gcttcgtagc tgcatgttac cacaatgccc 2296741 tttcgctcct ttacgtttcc ggcaactgcg accggctttc cccggagagc cggatcatat 2296801 gccatttcaa ccgacgcata aaagctattc atatcaatat ggaaaataat tcggctcttt 2296861 cccggcataa acaaatctcc ttttcggtca ttagacaaca gcttgtacat atagtaaaat 2296921 gaagctattg aatggatgtg atgacaatgt ttgtggaatc gataaatgac gttttattct 2296981 tagtcgattt tttcacaatt attcttcctg ctctaacggc aatcgggatt gcattcctct 2297041 tacgggagtg ccgtgcgggc gagcaatgga aatcaaaacg aacagatgaa catcagacgg 2297101 tctttcacat taaccgaaca gactttctta ttattatata tcatcgcatt acaacttgga 2297161 tacgtaaagt cttccgcatg aattcgcctg tgaacgatga ggaagacgcc ggttctcttc 2297221 ttttataaac cgcatttata aaaaggagga gaacaaaatt gttaaaaaca tatcaaaaac 2297281 ttttggctat gggtatcttt ttgatcgtat tatgctcggg caatgctgca tttgcagcga 2297341 ctaatcaggt gggaggcctc agcaacgtag gttttttcca cgattattta atcgaaccgt 2297401 tttccgctct gcttaagggt gttgccgggc tgtttcacgg agaatacgga ctctctatta 2297461 tcctcgtaac cattattgtg cgtatagttg tattgccttt gtttgtcaat cagttcaaaa 2297521 aacagcgcat cttccaagag aaaatggccg ttattaaacc tcaggttgac agtatccagg 2297581 ttaagttgaa aaagacgaag gacccggaaa agcaaaaaga gctgcaaatg gaaatgatga 2297641 agctgtatca ggagcataat atcaacccgc ttgcgatggg ctgtcttcca atgctgattc 2297701 agtctccgat tatgattggg ctttattacg cgattcgctc aacacctgaa attgcgtcac 2297761 actcgtttct atggttcagt ttagggcaat ctgatattct catgtccctt agtgcaggga 2297821 ttatgtattt tgtccaagcc tatatcgctc aaaaactgag cgcgaaatat tccgctgtcc 2297881 cgcaaaaccc tgcagcgcag caatccgcaa aattgatggt gttcatcttc cctgtgatga 2297941 tgacgatttt ctcgcttaat gtgccggcag cccttccgct gtactggttt acaagcggac 2298001 tgtttttgac agtgcaaaac atcgtccttc agatgacgca tcataaaagt aaaaaaacag 2298061 ccgctcttac tgagtcggtg aaataaaaaa gcaaccccgt gcaaaaagcc ggggttgttt 2298121 tttgttactt gcaaagtacc gcgccaaaca gtcttgttta tcatggctga agcagaaatg 2298181 gccatcctaa aaaatagccg tatcgtttaa aaagaaggaa atcgggaata cctttactca 2298241 cctccaaccg aaaggagcct atacgttgac ggaacgcttt cagcaaaaaa atatttctgt 2298301 acctgatgga atctggatca tgagacaaac ctggaatgat gtcttatttg ctcactggcc 2298361 tgttgatgtt tctatccttc gcgctttggt accgtccgtt ttagaattag atacatataa 2298421 cgggcaagct tggatcagca tgcttccctt tatgctcacg aacctgaggg cgcgttatct 2298481 ccctgtcatt cccggtgcgc gtgcatttcc tgagcttaac ctccgcacct atgtcacgta 2298541 taaaggcaag cccggcattt atttttttag cttagatgcc gatcatcgtc tggcggtcct 2298601 tggcgctcgc acattctttc atctgcctta tttttacgcg gatatgaagt ccgaaaaaaa 2298661 cggtgatgcc attgactatg tcagcaagcg gaaaaatgac aaagaagcag cattccacgc 2298721 cgcataccgg ccaatttcag cgccttttac agcagaaaag gattcgctcg attactggct 2298781 gacagaacga tacaggctct acaccactta tcgcaataag ctctattacg aagacatcca 2298841 tcatcatccg tggctgctgc aaaacgccga agcagaaatt tcagtcaata cggtgactga 2298901 tgctcacggt attacattgc cggagtcaga ccccttgctt cattatgcta aaaaacagga 2298961 tgtgttattt tggccgctta ggaaatggag ctaaaaaaac ccgatgcggg aaatcgcact 2299021 cgggttttct ttttttattt tgccgcctct tcaataatgg caacaaccat ttctgccgtt 2299081 ttaacgagct cttcgatcgg cattttttca ttttttgtat ggatttgctc ataaccgaca 2299141 gcaagattga ccgtcgggat gccatgacca gcgattacgt tcgcgtcgct tccgccgccg 2299201 ctcgtttgca gctcgcttgg acgtccgatt ttagcagccg cttttttcgc gatttcaaca 2299261 acttggtcgc cgtcttgata tttaaagccc ggatacataa cctcaatttc gacttctgcg 2299321 cgtccgccca tatcagcagc tgcctcttca aaagcagctt tcattttttg aacctgagct 2299381 tccattttct caggaactaa agagcgcgct tcagcaagaa tatgaacttc gtcgcacaca 2299441 atgtttgttt gtgtgccgcc ttcaaaccgg ccgatattag ctgttgtttc ttcatcgata 2299501 cggcccaatg gcatttttga gatggctttg ctagcgattg taatcgctga aatgcctttt 2299561 tcaggttcaa ccccggcgtg agcggttttc ccgaaaattg ccgctcttac cttcgcctgt 2299621 gtcggcgcgg ccacaatgat atttccgact tttccgtctg aatcaagagc atagccgtag 2299681 gatgcagtga tcatagaacg gtcaagcgcc ttcgctccga tcagacccga ttcttcccct 2299741 actgtgatga tgaattcaat cgtgccgtgt tcaatatttt cttctttcag caccttaatc 2299801 gcctcaaaca ttgcagccaa tcccgcttta tcatcagcac ctaaaatcgt cgtgccgtca 2299861 gttttgacgt aaccgttctc tacaactggt tttacgccgt ttccgggtac aactgtgtcc 2299921 atatgagatg taaaatagat cgtatctgtt tgttttgtcc cttttagcgt gcaaatcagg 2299981 ttaccggctc cgtggcccgt gatatccatt gtatcgtctt ctttaacgtc cacacctaaa 2300041 tcagaaaatt ttcgtttcag cactttgcag atttcagctt cgtgctttgt ttctgagtca 2300101 atttggacaa gctctaaaaa ttcttccagc aggcgttttt cattcaccat ttgtaagtcc 2300161 ctccatatta aagcggtatg ttaccgtgct tttttttcgg tctctcttct gtcttatgtg 2300221 taagcatatg aaaagcttga atcagtcttc cccttgattc ttccggcaaa atgatgtcat 2300281 cgaccattcc acaagcggcc gctttgtatg ggccggcgtt ttgctttttg tattcagcag 2300341 ttttttcgcg tttcgtcttt tgcgggtcag ctgaagcttt gatttccttt tcatacaaaa 2300401 tcgatgccgc accttctgga cccatcactg cgatttcagc attcggccat gcaaacacaa 2300461 ggtccgctcc gatcgctttg ctgttcatgg ccacataggc gccgccgtac gcttttctaa 2300521 tgatgagtgt gacttttggg acagtcgctt cagcataagc aaacaataat tttgctccat 2300581 gcctgatgat tccgttgtgc tcttgctgaa tacccggcag aaaccccggg acatcttcga 2300641 cagtcaacag cgggatatca aatgcgtcac aaaaacggat gaaccttgct gctttatcag 2300701 cagcgtcaat cgtcaggctt cccgccagat gcttcggctg gctcgccacg atgccgattg 2300761 ctttttcacc cagccttgca aacccaatga caatgttctt cgcaaaaaat ggctgaatct 2300821 caaaaaaaga ctgcgggtca gccagctccc taatcacctt ccgaacatca taaggctttg 2300881 tcgtatcagc agggacaaga cggtttaata acggtctgga cgcctctttc tctggcttcg 2300941 gctctgttgt ccggccattc agcggcaaat aagacagtag ttttctcacc cctgtcagaa 2301001 cctccttctc cgtatgcccg gaaaagtggg cgtttccgct gacggcatta tgtatccccg 2301061 ctccgcctaa gctctccgca tcaacctgtt cccctgtcac tttttcaatc accttcgggc 2301121 cggtaataaa catccggcca gtctgttcag ccataaatat aaaatctgtg agtgccggag 2301181 aatatacagc gcctccagcg cacggcccta aaataaccga tatttgcgga atgactccgg 2301241 aatataagac gtttcggtaa aatatgtgac cgtatccatc taatgataac acaccctctt 2301301 gaattctcgc accacctgag tcattcagcc cgataatcgg cgccttattt tttgctgcca 2301361 gatccatcaa agcgcagatt ttcctggcat gggtttcgcc aagcgcccct ccgtacactg 2301421 tgaagtcttg cgcaaataca taaactgagc gaccgtcaat tgtgccgtac cctgtcacga 2301481 ccccatcccc taacatgcgc tgttctcttg ttaacacttg actttccatg aaggggtgta 2301541 attcgataaa gctgtcctga tctagaagaa atatgatcct ttcccgagca gtgagcttgc 2301601 ccttttgccg ctgctgagcc agcttttccc gtcctccgcc ttcttctgcc tgcttgcgtt 2301661 tcgtgtaaaa atgatccatg tgctcattca tgctcattgt gttggtctcc tttcggttca 2301721 caaagctcta caagaacacc gtttgtttcc cgaggggaaa taaacgcgat ctttttcccg 2301781 ttcgctccct gtcttggaaa cctgtcaatc aattgaacat gctgatcaga caatgcttga 2301841 agctgttcag ataggcagtt gcacaaaaac gcaatatgat gcagtccctg ccctttcttc 2301901 tccaaaaata aatggacggg gctgtcagct gtcaacggct ctatcagctc aagtttgacg 2301961 ctaccagctt gaaaaaaagc aacattcacc ttttgctctt caaccgtttc ttgatgaaga 2302021 aatgcaagcc ccaatacatt ttcataaaag cttcttgcat cttttatcga aaaaacggct 2302081 atcccgatat ggtcaagcct gttcattttc atccctgctt tcgctaatag atatcgcttg 2302141 tccgcccatt caaaacacgc taaaatatag acagattgtt taaggagtga aaatcatgtc 2302201 tcaaaaactg atgaaaagcg ttttgatcgt gattttggga gtttttattc tttcaactgt 2302261 actctcagga atcgtcatgt ttctataacg ataaaaaagc aggcgcctta ttcaatggga 2302321 atatcctgct tttttatcag agctttatgc tcgatggcaa tctcctcaaa agagcggttg 2302381 tcgtccgtga tcagcactct cgttcctact ggtatcgttt gaaacaaatg aacaacctca 2302441 tcgttatgca tacgtataca gccgttagac acaaattttc ctactgattc ctctcggttt 2302501 gtcccatgaa ttccataaat ccgcccgtcc gttcctttcg cgtcaaatcc gatccatctt 2302561 gccccaagcg ggttatcagg agatccccct tcaatatttt tctttctgta gtaaggattt 2302621 tccgctttta ccgttaccga aaactctcct tcaggcgtca aatcatctgt ttttccagtc 2302681 gccacactat acacgccttc tactttgttg tcgaggataa cagcaagttc atttgttcgc 2302741 ttgttgacaa taacatacgg atcacccggc agcggatttt cgccgagcgg ccaaatcggt 2302801 gaaatcatca tgaaaatcga acataagaaa aaacgcataa gctcctcctt tttcattagg 2302861 ttgaccaatg aaggaagagc tcatgcgaat catccgagtg atttttgcgc ttttattcct 2302921 ttaaaataac ttttaatcac taaatattgt tccatttcgc cgagaagatg gaagagagcg 2302981 gccctcgctt caaattcctc tctagtcgca ggaagcggca tctcctcaaa ttcttttctc 2303041 atgtcagcaa gtcttttcag aaatttgtat gctgtattcc cagggtgtat cgcctcccgc 2303101 aaatcatgaa taaattcagc gatcattttt ccctgatcta ccgtgatgga gatcgatgtc 2303161 actttaggga gaaggcgttc gataatttca aattgctttt ctctcatttt aaaataatga 2303221 taatgcagat tttcataacg caaaatgtgg ttttgcacat ctcgatatgc caggttttta 2303281 gcctccgtaa tgagctggtg cgtttccgga atttcttttc ctgaccaatc ttgctcacca 2303341 gttaacaaat accgttcgat ttctgcaaaa atgacagcaa agttatcctc tatctttttg 2303401 cggtaggcaa tcagtttccg gtcaagacta ggcatataca agttcatcaa tagagcgacg 2303461 ccgatgccaa ccgtaatcag ctgaacttca ttccagatga aagtaggcgt aatgccgccg 2303521 gacatgtata aatgaaggat aataacagaa ctggtgacga taccctcgtt aatttttaac 2303581 agaaccgtta tcggaatgaa tatcaaaaga agcgctccga tcacaaacgg gtggtagcca 2303641 ataagctcga aaaagagata agaaaaagca attgccagac agcatgccga aaagcgggcc 2303701 catgaggcct gaagcgaccg tttttgtgtg atttgtatgc acaaaatggt gatgattcct 2303761 gctgatgcga agttttgcaa atgcaataac tggcttatat aaatagccaa agctgttcca 2303821 agcgcggtct ttattgtgcg gtaaccaatt ttaaacatgt cggactccat ttctatttgt 2303881 ttcttcaata aaaaagaaga ggcggccagc cttcttcttt tttatattct ataatatttt 2303941 ctctaaaaag tcctgcgctc ttttggattt tggcgacata aaaaattcct tcggattgcc 2304001 gtcttcgaca atcattcctt ggtccataaa cagcacacgg tctgccactt cttttgcgaa 2304061 gcccatttca tgtgtgacaa tcaccatggt catgccggtt tcgaccagct ctttcatcac 2304121 ctgtagcact tctttgacca tctctggatc aagggcggag gtcggctcgt caaacagcat 2304181 gatgtccgga ttcatcgcaa gagccctggc aatcgcgaca cgctgttttt gtccgccaga 2304241 caaacggttt ggatagtcat ttcgcttttc aaacaaaccg actttgcgga gcaggtcctc 2304301 agctttctcc tgtgcagcct gttttgattc tttttttaca ttgacaggcg cgtacatgat 2304361 gttttcgaga accgttttgt gcggaaagag atgaaaatgc tgaaaaacca tcccgatgtt 2304421 ttcccggacc tttaatgtgt tggttttcgg cttcgtaatc tctgtgtctt ttattgtaat 2304481 ggttccgccg ttaggctttt ccaacaggtt taaacagcgt aagaacgttg atttgcctga 2304541 gcctgaagga ccgatcacgg caacaacctc accctcagcg attgttgttg aaatgttttt 2304601 taatacttcg tgtttcccaa atgattttga cagcttttca accttaatca ttggatttca 2304661 gcttcctttc tacagccttg ccgataaacg ttaaaatcag gacaagcaca taataaatca 2304721 atcccgcgat aatgagcggc tcaaggtaat tgtaagtggc ggcgccagct tgatatgcgc 2304781 gtctcatgac atcaccaagc ccgatgacgg tgacgatcgc cgattctttt gttaacgtaa 2304841 ttaattcatt cacaattgca ggtgatatat ttttgaaggc ctgcggcagc agcagatcct 2304901 tcatcatttt tccatacggg acaccgagtg caacagcagc ttctttttgc cctttatcaa 2304961 tggcattgat tccggctctg ataatttccg atacataagc ggcggaattc aaagacaatg 2305021 cgacaaccgc agcccaaaac tggtcaattt gaaatccgag cagctgagga aggccaaaat 2305081 agacaatcat aagctgcagc actaaaggcg tgcctcggaa cactgatgta taaaaatcag 2305141 cgatccagat aaacgggcgg aatgtgctga tcttgcataa gcttagcaca ataccgagta 2305201 taagtccgat aatagcagat acaacaacaa tttttaatgt aattgccaag ccttctaata 2305261 taaaaggaat ttgggggatc gttgctgaaa aatccaaatt catagccttt gtctcctttt 2305321 cttacaggaa aaaagtttcc tattcaataa aaaggctcaa cgaaaaagtt gagccgcttt 2305381 tttttacttc tcgccagtga accatttttt cttcaatttc tcaagctctc cgttatcttc 2305441 catttccttg agcgctttat tgaatttgtc tgtcagttca ctgtcctttc tgaaagcaat 2305501 tgctgaaccg gcttcttccg ctttcgcatc aggaatcaca aagccttgca ggtcatcatt 2305561 tgatttgaaa tacccttctg caacaatgtc ttcaataatc gcggcatcga agcggtcaga 2305621 tttgatttcc tgcaccaaat cagaaattct gttgcggtct tctgttttaa aaccatattc 2305681 cggagaaagc tctttcccct tctcttcctg aatagagcca agctgaacgc caactgtttt 2305741 tcctttcagg tctttcaaag attgaatgcc gctgtctttt ttgctgacaa tcatatggtt 2305801 cgctgtgtaa tacacatcgg aaaaatcaac ttgtttttta cgctcaggcg ttggtgtcat 2305861 tcctgacaga acgagatcca cctgttttga tttaagcgct gtaattaagc tgttgaagtc 2305921 catatcctgc acttcaattt catagcctgc cttctttgcc agagcttttg ccagctctac 2305981 atcaaagccg acaatattat ctccttcttt atattcaaac ggtttgtaat ccgccgaagt 2306041 acccataatt aattttttct ttccgctttc tgaacctgaa ttgcttgagc cgcacgcagt 2306101 taatgcaaag gtgatgcaag cagccacaag taataagagc cattttttca tgatccattt 2306161 cccccgtatt cattactttt ggtgtatttg aatatttatt cgttaatttg tattttaaac 2306221 agtttctcat ttttatgcaa tactattttt aaaaattatc tttaggctta tctttccagt 2306281 gatctcttct gatattacta gataaaaatt aaatcgctgt acaatccgat tgaataatcc 2306341 cttaatattt attcatatat ccttggaaat ttatgcacaa aaaaacccgg gctgctttga 2306401 gcatccgggt tgttcgtctt atacttcttc acaatattct tcaaaggctt cctgcagctt 2306461 tgccactaca gccatcggct catggccttc aatttcatga cgctctacca ttttcatgat 2306521 ctttccgtct ttcaaaatcg caaaggacgg agaagatggt ggataacctt caaaatagtc 2306581 acgcgcacgc gctgtcgctt ctttatcctg tccggcaaaa acggtgacga gctgatcagg 2306641 tcttttatca tagtgaacgg aatggtaggc tgccggtctt gcaattcctc cggcgcatcc 2306701 gcaaacagag tttaccatga cgagcgtcgt tccttttttc gtaagtgcct catccacctc 2306761 ttcggctgtt ttaagctcgg tgtatccggc agctgttatt tcttgtctcg cttggcggac 2306821 aatatcattc ataaataaat taaagtccat gttcaatgaa gacctctcct ttttcatcat 2306881 ctgttcttat gatagcaagg aaacgtccat atcggcaaat gactttgctt cgccgtgcac 2306941 tttttttgct cttcgtttac tgcttacaga aaaaggggat tatataacca gaagtaaaat 2307001 aaaggagcag ttgtatatga gccaccggaa agcgttactg attcataacg gaaatgccgg 2307061 caacaaaaat atagaaaaag cacttggtgc tgtggtgccg gttttatctc accatttaga 2307121 tgaggtgatt attaaacaga caaagaaaaa ggatgatgcg tatcattttt gccgatccat 2307181 tgatgattct gtcgacaccg tcttcattct cggcggcgac ggcacgatcc atcaatgcat 2307241 aaatgctatc agcgctctag aaagaaaacc cgctgtcgga attttgcccg gcggcacgtg 2307301 caacgacttt tcaagagtgc ttggcatccc tcaaaatctt gcaaaggccg cggaagcact 2307361 tatggcggga aaaaaaacca gcgtagacgt atgtcagatg aatgaccgtt attttttgaa 2307421 tttctggggg atcggcttaa ttgcagaaac gtcgaatcaa atcaacgaaa cggaaaaagc 2307481 attattggga aaaatcagct attttacaag tgccttgcga accgtctcat ctgctgcatc 2307541 gtttccgatg acattaaaaa ttgatggaga agaaattaaa gaagaagccg ttatgctgct 2307601 tgtgatgaat ggccaataca ttggaacgaa tcgaattcct ctgcccgatg ccagtattga 2307661 agacggctta cttgatgttc tcatatgccg caataccaac ctcaccgcgc tgcgggagct 2307721 gatgagcatg gaacaaggct caattgatcg ttttactgga gagttgtcct atgtccaggc 2307781 ttcccgtatc gagattgaaa cagacactgc caaaaaggcg gatatggatg gagaagttta 2307841 tacacataca cccgcagtca ttcaggtcct gccacagcat atcgacatgc ttgttcccgc 2307901 aaatgaataa ctgtcataag gctttagaaa gattttgcaa atccgttgac tctcccctag 2307961 gaggaggtct tacagtataa gggatacaca cttgaaaaag gggaagtcat atggagaaga 2308021 aaaatattac cttaactata ttattaacca atttatttat tgcttttttg gggatcgggc 2308081 ttgtgattcc agtaacgccg accattatga atgaattgca tttatcgggg accgcggtcg 2308141 gctatatggt tgcctgcttc gctattacac agctcattgt ctcaccaata gccggacgat 2308201 gggttgatcg cttcgggcgc aagatcatga tcgtaatcgg cctgttgttc tttagtgtgt 2308261 cggagttttt gttcggcatt ggaaaaacag ttgagatgtt atttatctcc cgtatgctgg 2308321 gcggtatcag cgcagccttc attatgcccg gggtcacggc ttttattgca gatatcacga 2308381 ccattaaaac acggccaaaa gcgctcggtt atatgtcagc cgctatttca acaggattta 2308441 ttatcggccc cggcatcggg ggatttttag cagaagtcca ttcccggctg ccttttttct 2308501 ttgcggcagc ttttgcactg ttagcagcca ttttatcaat cctcacgctg cgcgagccgg 2308561 aacgaaaccc tgaaaatcag gaaataaaag gacagaagac aggctttaaa cgaatttttg 2308621 cccccatgta tttcatagct tttctcatta tcttaatttc gtcttttggt ttagcatcat 2308681 ttgaatcttt atttgcatta ttcgtggatc ataaattcgg atttacggcc agcgacattg 2308741 ccattatgat tacaggagga gcgattgttg gcgccattac gcaagtcgtc ttattcgacc 2308801 gcttcacaag atggtttggc gaaattcatt taattcggta cagcttaatt ctctcgacga 2308861 gtctggtatt cttgctgaca acggtacatt catatgttgc gattctgctg gtgacagtca 2308921 ccgtatttgt cggatttgat ctcatgcggc ctgcggtaac gacttacctg tcaaagattg 2308981 cgggaaatga acaggggttt gccggcggta tgaattcaat gtttacaagt atcggcaatg 2309041 tattcgggcc tattatcggc ggaatgctgt tcgatataga tgtaaactat cctttctact 2309101 ttgcaacggt caccttagcc atagggattg cactgaccat tgcttggaaa gcgcctgcac 2309161 atcttaaagc cagcacgtga taagaagcgc attctttgtg tactgcaaag aatgcgcttc 2309221 ttctttatac tgatgataga aggagtgatg gcatgaagga atcgtattac tcaattgggg 2309281 aagtatcaaa actggcaaac gtgtcgataa aagcgctccg ttattacgat aaaattgatt 2309341 tatttaaacc agcctacgtc gacccggata ccagctaccg ctattataca gattctcagc 2309401 tcattcatct ggatttgatc aaatcattga aatatatcgg cacaccttta gaagagatga 2309461 aaaaagcaca ggacttagag atggaagaac tgtttgcttt ttatacagag caggagaggc 2309521 aaatcaggga gaaattagac tttttatcag ccctggagca aaccatttca ttggtgaaaa 2309581 agcggatgaa acggcagatg gaatatcccg cgctcggtga ggtgtttgtt ttagatgaag 2309641 aagaaatacg gatcattcag acagaggcag aaggaatcgg gcctgaaaac gtgctcaacg 2309701 cctcctacag caaattaaaa aaatttatcg agtcagcaga tggatttacg aacaatagct 2309761 acggcgctac tttctctttt cagccctaca ccagcattga tgaaatgact taccgtcata 2309821 ttttcacacc tgtattgacg aataaacaga tttcatcaat tacgccggat atggaaatca 2309881 caacgatccc taaagggagg tatgcgtgta tcgcgtataa tttttcgcct gaacattatt 2309941 ttctcaactt acagaagctt atcaaatata tcgcggaccg ccaattaaca gttgtcagtg 2310001 atgtatacga gttaatcata ccgattcatt actccccgaa aaaacaagaa gaatatcgag 2310061 tcgaaatgaa aatacggatc gctgaataat aaagcataga aaaagagcat tttttgaaac 2310121 aaaacttcaa aaaatgctct ttttgcttat ttagtaaaca gatgtcttct cgtcaatcga 2310181 ttctaaaatt tgtttcactc gtccgaggaa tcgtccgcac acgagaccgt caagcactct 2310241 gtgatctaat gacaggcaca gattaaccat gtctctgaca gcaatcatgc cattgtccat 2310301 gacaaccggg cgtttgacga tggattctac ttgaagaatc gcagcctgag ggtagttgat 2310361 aatgcccatc gactgaacag acccgaacga acctgtgttg ttgacggtaa acgtgcctcc 2310421 ctgcatgtca tctgcagtga gttttccgtc tcttactttt ttagctaggc cggtaatgtc 2310481 tttcgcaatg cctttaattg ttttttcatc agcgttttta atcaccggaa caaataaaga 2310541 atcctctgtg gcaactgcaa ttgaaatatt gatatccttt ttctgaataa ttttgtcccc 2310601 cgcccacatg ctattcattt gcgggaattc ttttaacgcc tgagcgaccg cttttacaaa 2310661 aaaggcgaag aacgttaaat taaagccttc tgtcttctta aaagaatctt ttatactgtt 2310721 gcgatatgca accatatttg tgacgtcgac ttccatcatc gtccaagcat gcggaatttc 2310781 tgttttgctt cgcttcatat tggaagcaat tgcttttctt acacctgtga cagggatttc 2310841 tttatcaccg gctgcagacg caggatatga cgtctcttct tttggctcag gttttgatgc 2310901 agacttcggt gcaggagctg ctgttttcag ctcctcagga ttctgttctt gcacgccgcc 2310961 tgtttcaatt aagcgctgaa tatcttttcg tgtgatgcgc ccgccggcac cagttcctgt 2311021 cacttgatcg aggtcaatgc cgtgctctcc ggccaaacgg agaacagctg gcgagtagcg 2311081 ctttttattg ggctgatcgg ctgctccagc actttttgca acagggttct cagcggcttc 2311141 tgatgctgct ggctgttctt gtttttgttc agccggattc gcgccttctg tttcaatttt 2311201 gcaaatcatt tctccgactt gcagggtttg gccttcttct cccacaagct ctgttatcgt 2311261 accagtaaaa gaagacggaa cctctgcatt taccttatct gtcatgactt ccgcgatcgg 2311321 atcgtatttg ttcactttat caccgggggc gacaagccat ttgctgatcg tcccctctgt 2311381 tacgctttct ccaagctgcg gcatcgtcat ttgttcaatt gccatgattg tatcctccct 2311441 tacgtcttta aaactccgct aattctctca tcgccgcttc cactttatca gggttgacca 2311501 taaagtattt ttccattgtc ggcgcataag gcatagccgg aatatcagga cctgcaagcc 2311561 gtttgatcgg cgcgtctaag tcgaacagac aatgctcgga tataattgcg gctacttcgc 2311621 tcatgatgct gccttctttt gtatcttctg tgaccaaaag aacctttcca gttttggacg 2311681 cagcttcgat gatggcttct ttatcaagcg ggtaaactgt tcttaaatcc accacatgcg 2311741 ctgaaatgcc atctttttcg agacgttctg cagcttgtaa ggcgaagtgg acacacaggc 2311801 cgtatgtgat cactgtgatg tcgtcgcctt ccctttttac gtccgccttg ccgattggca 2311861 ggacataatc atcagccgga acctcgccct ttatcagacg gtatgcccgc ttgtgctcaa 2311921 aaaacagcac ggggtcttcg tcacgaactg cggcttttaa gagccctttc gcgtcatatg 2311981 gtgttgatgg catgacaatt ttcagtccgg gctggttggc gaaaattgct tcgactgatt 2312041 gagaatgata cagggctccg tgcacgcctc cgccgtatgg cgctctgacg acaatcggac 2312101 agctccagtc attgttgctg cggtagcgga ttttagccgc ttcagaaata atttggttga 2312161 ctgccggcat aatgaaatca gcaaactgca tttcagcaat cggtctcatt ccgtacattg 2312221 ccgctccgat accgactcct gcgattgcag attcagcaag cggcgtatcc ataacgcgct 2312281 cttccccaaa ttgttcatag agtcccgctg tcgctttaaa cacaccgcct tttcttccta 2312341 catcttcccc aaggacgaaa acgcgagaat ctcgttccat ttcttctttc atcgccaaat 2312401 tgattgcatc aatatatgac attactgaca tttgttcttc ctccctactt cgcataaaca 2312461 taatcaagcg ctgactcagg agctgcatat ggggcgttct ccgcttcatc cgtcgcttca 2312521 tttacgattg ccataatttc atccagcatg gtttgttcta tctcatcgga cagcaggcct 2312581 gtttccttta agtaagcttg ataagtaagc aggggatcac tttttttcgc ttcctctact 2312641 tcttcacggc ctctgtagct gctgtcatcg tcatcactgg aatgtggtgt aaggcggtaa 2312701 gaaatcgttt caattaatgt cgggccttct cctctgcgtg ccctttcgcg tgcttcttta 2312761 accgcttgat aaacttccag cggatcattt ccattcacag ttacgccagg catcccatag 2312821 cctatggcac ggtcggaaat gttctcacat gcgacttgct tatcgtaagg cactgagatt 2312881 gcgtatttgt tgttttcaca catgaaaata accggcagct tatggacagc ggcaaagttt 2312941 gccccttcat ggaaatcgcc ttggtttgaa gacccttccc cgaatgtaac aaaggctgcg 2313001 atatcctttt tctccatacg tcccgcaagc gcaataccga ctgcgtgcgg cacttgcgtt 2313061 gtaaccggag atgatcccgt cacaatgcgg tttttctttt gtccgaaatg tcccggcatc 2313121 tggcggcctc ctgagttcgg atctgctgct tttgcaaacc cggacatcat taagtccttt 2313181 gctgtcatgc caaacgcgag cacgacaccc atgtctctgt agtacggcaa tacataatcc 2313241 atttcacggt caagtgcgaa agccgctcct acctgtgctg cttcctgtcc ttgacaagag 2313301 attacaaatg gaattttgcc agaacggttt aacagccaca ttctttcatc gatttttctt 2313361 gctaacagca tggttctata catatcaacg gcttcctgat cagtcagccc tagtgcttga 2313421 tgtcggtttg tactcattca agcccctcct ttatgctttt aaaaatgaat ggctttgcca 2313481 tctgcggcaa gcgcagcttc tccaattgct tcagaaagcg ttggatgcgg gtgaatcgtt 2313541 tgcccgacct cccacggtgt tgcgtccagc actttggcaa gacccgcttc agaaatcatg 2313601 tcggtgacat gcgggccaat catatgaacg ccgagaatat catctgtatc tcggtcagcc 2313661 acgattttga caaaaccgtc gctttcaccg tatacaagcg cttttccaat cgccataaat 2313721 gggaacttgc cgattttgac attatgcccg ttcgcctttg cttcgtcttc ggttaagccg 2313781 acactggcag cttcagggct tgagtaaatg cacttcggca caagcgtcgg atcaagcgga 2313841 tgcggattga gacctgcaaa atgctcaaca gcaataattc cctcatgtga agcaacgtga 2313901 gctaactgca ggccaccgat tacgtctccg attgcataaa tatgagattc cttcgtttgg 2313961 cagctttcat tgactgaaat catgccattt tcagtaacaa tatcggtgtt ctctaggccg 2314021 atgccttcga tatttgcctg tctgccgatg gaaacaagca ttttctcagc agaataggta 2314081 acggtttctc cgtctttttc cgcttgtatg ctgatatcgt ctgatgtttt tgtcattgtg 2314141 tcaggcagca cttttgcccc tgttatgaac tggatgcctt ttttcttaag aagactttcc 2314201 atttcttttg aaatctctag atcttcagtc ggcaatatgc gatccgcgta ttcaataacc 2314261 gttaccttaa cgccaaaatc atgaagcata gacgcccatt cgataccgat aacccctccg 2314321 ccgacaatga tgattgactg tggcagctcc tccatttgga gcgcctcatc tgaagtcagt 2314381 acagacttac cgtccacttc aagacccgga agcattctcg gtcttgatcc tgttgcaatg 2314441 atcacttgtt tcgggatcag catgtcattt tcttcgccat ttccccgctc aacagaaatt 2314501 gttcccggca gcggagagaa gattgacggt ccaaggatac gtccatatcc ggtgtacacg 2314561 tcaatttttc cttttttcat taaatgattt acacccgctg caagcttatc aacaacggct 2314621 tgcttacgct gctgcacttt ttcaaagttg agggacacgc cagccgtttc cactccgaat 2314681 tgatcggctt cacgagctgt ccggtatacc tctgcgcttc taagcagcgc tttactcggg 2314741 atacagcctt tatgcagaca tgttcccccg agtttttcct tttccacaac ggctgttttt 2314801 aagccgagct gagcggctct gatggccgca acataaccgc cggtaccgcc gcccagaatg 2314861 actacgtcat actcagttgc catggtgact cactcctgtc tgtctattca atacgatatt 2314921 gtttggattg ctcttcgccc tgcaatactc ttagcgcccc ttgggcaaga gactgcagtt 2314981 cattttcacc cggataaact aaaacgtctg aaatccaatc tatgtatgat ctgatagcag 2315041 aaacaaagct ttttccgtac gcaaggcctc ccgtcagcac aatcgcttca acttcgcctt 2315101 ttaacgccgc gctggctgcc ccgatttcct ttgctacctg atatgccatg gcatcataaa 2315161 tgaagcgggc tttttcatcg cccccttgaa tcatctgttc cacttttact gcatcatttg 2315221 taccgagata gcctaaaagt ccgccggtgc caacaagctt tttcatgatt tcttcttttg 2315281 tatattcccc tgaaaaacat agatcaacaa gatctcccgc aggcactgtt cctgctcgtt 2315341 caggactgaa tggtccctcg ccgtgcaggc cgttattgac atccaccact cgcccgcggt 2315401 catggacgcc aattgtaata cctccgccca tatgggtaat aatcattttc atgttctcat 2315461 atcgtttgcc aagggaggct gccgctttac gagcgacagc tttttggttt aacgcatgga 2315521 aaatgctttt cctttcaatt tcaggcatgc ctgaaacttt cgcaagcact gacatttcgt 2315581 ctacgacaac agggtcgacg atatacgaag ggatattcag gccgtcagcg atttcccgcg 2315641 cgataatgcc gccgagatta gaagcatgct gaccggcgta gccgcttttc aaatcctcaa 2315701 tcatctcatc attcactacg taggtcccgc cttcaattgg ccggagaagg ccgcctcttg 2315761 cgcagactgc atcaaacttt gaaatattga ttccctgttc atgaagcgtt tcgagaatat 2315821 ggtttttacg aaattcatac tgatcaataa ttcggtcaaa tcgctgcagc tcttctatgt 2315881 tgtgtctcaa tgttttttca aaaatgcttc tttcgttatg aaaaacaccg attttcgttg 2315941 aagttgagcc tggattaatt gtgagaatgc gtttttcgtc atgtagcact ttcataacct 2316001 ccagatcaat ttcttaacgt ctgcttaata cactgtggcc gttttgcaaa aactggcttc 2316061 ttgagcggcg catgcgttca atccgttcct ctgctaagcg gtcagccgct aaatatgcag 2316121 gaatgccgtc acgctgagaa atctcaagta cacgctcgat attgccgtaa atgccttcaa 2316181 cttttttcaa tgcacgttct gcattatagc cgtaaagctc atctgccacg ttgatgacac 2316241 cgcccgcgtt aatcacgtaa tccggtgcat aaacgatgcc catttcgtga atttgatcac 2316301 catggcgtgt ctcttttaat tggttgttag ccgcacctgc gatcactttc gccttcagct 2316361 gtttaatggt gtcgtcgtta atagtcgcac caagggcaca cggcgcataa atatcgcagt 2316421 cttgtgaata aatgtcatca ggatctaccg cacgggcgcc aaaatcttca actgcacgct 2316481 gtacagattg tttgttgata tccgtaacga ttaagtttgc tccttcttca tgcaggtggc 2316541 ggcaaaggtt ataggctacg ttcccaacac cctgtacagc aatggttttt ccttcaagag 2316601 agtcggttcc gaaagcagct ttagctgctg ccttcattcc tctgtacacc ccgtacgctg 2316661 tgactgggga cggatttcca gaagagccga aagcaggaga aatccctgtg acatagtctg 2316721 tctcatcatg aatgatatcc atatcctcga ccgttgtgcc cacatcttca gccgtgatgt 2316781 atctgccatt cagtccttga atatagcggc caaacgcgcg gaacatttcc tcatttttgt 2316841 ctttgcgcgg atcgccgata atgactgttt ttccgccgcc aaggtttaag cctgccgccg 2316901 cgttcttata ggtcatgcct cttgccaatc tgagcgcatc ttcaattgcc gcttcttcat 2316961 tttcatatgt ccacattctc gttccgccaa gcgccggacc aagcgttgta tcatgaatgg 2317021 cgataatcgc ttttaatcca gattgttcat cctggcagaa taccaattgt tcgtaatcgt 2317081 atttctccat atatttaaaa agttccatgt tcgttcctcc taatgtgtgt attcttcaga 2317141 tgcgcatatt gccagcgcaa tggaatacag tttattttca gcagagtccg ctctgcttgt 2317201 taaagcaatc ggtgcttttg ctcctgtaat gacagccgcc acgctggcct tggcaaaata 2317261 aatcagtgat ttatataaaa tattgccggc ctcaattgtt gggacgagaa ggatatctgc 2317321 gttgcccgct acgtctcccg aaattttttt ctgggccgcg gcaatttgtg aaactgcgtt 2317381 atccaaagca agcggtccat caacaatgca gcctttgatc tggccccttt tgtacatttg 2317441 agctagagca gctgcattca cggtcgcttc cattttaggg ttcaccgttt cgaccgctgc 2317501 aagggcagct gcttttggca tattgttccc cactgcatgg gccacatgaa cggcattttg 2317561 caaaatctgc cggagctctt ccagcgaagg agcaatattc attgccgaat ctgtcacaaa 2317621 catcagccgg tcaaaatccg gtatatcgaa gacagccacg tgagaaagga cacttgctga 2317681 ccgaagcccc tcctgtctgt tcaataccgc tttaagcaaa acagaagtcg gcacattgcc 2317741 tttcattaaa acgtccgctg ttttatgatg cacagcacga accgctaatt tcgccgattc 2317801 ctcaggagta ttggcatgga cgatttccac ttgatgccct tgcatggatg atgtcagctc 2317861 gttcagtttt ttgctgtcgc ccgttaacaa gaaacgggcg gataggtgct cggctgccag 2317921 ctttacagcc cggatcactt cctcatcctc agcatgagca accgcaatgg tcttattttt 2317981 gtgtatcgac gctttgccga ttaaatcttt cagcttcatc tgttaccacc tttcttgttt 2318041 cgactccgcc ttttattatg caagttccat gccagctctt aagggtgctg tcataccagg 2318101 tataccgaaa cattcgtgca gatgtttgcg tttattctgc aaattattgc atgccttcat 2318161 ttgcaaggcc atatttatcc attttgtaat ataaattccg aatgctgaca ccgagagctt 2318221 ttgctgtttt tgtccggtta aaatgatgct tttcaagcgt ttgctggatc aaatgcgctt 2318281 caaatttttc tactgcgaca gacagctttt cgccttcaat atccggaaaa tcaaaacctg 2318341 ttccctgatc tgtgtcattt tctttttgct caagttcgaa tacaggcaag tgatcttttt 2318401 caatccattc catatgcgga ttcagaaaaa tcatggctcg tccaaggaca ttttcaagct 2318461 cccggacatt cccaggccaa tggtaggcag ataaggcgcg caaggcttgc tgtgagagcc 2318521 cttttacatt cctgccgtaa tcccggttga tcttttggat aagtctgacg ctcaatgctt 2318581 caatgtcctc caaccgctgc cgcaaaggcg ggatggagat cggatagcga ttgatccggt 2318641 aatacaggtc ttcccggaat gttccgtccg ccatcgcctt ttcaatattt acatttgtcg 2318701 ccgcgatcac tctgacgttg acagggatcg ctttcgtgcc gcccactctg acgatttcct 2318761 tttcttgaag gacgcgtagc aatttggcct gcatattttg tgtcagctca ccgatttcat 2318821 ctaagaaaat actgccgtta tttgcttcct caaataaacc ctttttaccg ccgcgcttcg 2318881 ctcctgaaaa cgcaccatcc tcatagccga acaattctga ttcgagcagg ttttcagaaa 2318941 gggctgcaca attcacgcga ataaatttat tgtatttccg gtcactttcg ttatggatgg 2319001 catgggcgaa cagttctttt cctgttcctg attccccgcg cagcaagatg gttgccggtg 2319061 ttttcgcacc gagcttcgcc tgctcaagcg caaccagcat ttgctcgctt ttgccgataa 2319121 tgtcgtcaaa cgtgtatttc gcttcaagcg tgcgaataat ttgtctggcg cgattaagct 2319181 ccgctgtcag cattttaatt tcggaaacat cgtgaatcac gccgacgctg cctttcaaaa 2319241 tcccgtccac aatcaccggt gctacattaa cgatcacttc tttttcattc gggccgacct 2319301 tcattctgac accgcggaca ggacgtcttg tttcaagcac ctttaaatgc atgctttcgc 2319361 cttcggaaat atcagtgttt gcaggcttgc cgatgacttc tttttcagaa agccccgtca 2319421 ttttcgtata cgctttattg attagcaggc cgatgccgtt ttcatcaacg acagaaatcg 2319481 cctcatcgga ggattgaata attgcctcca gcatcgtacg gacctgcttt aagttggtca 2319541 cttcctctgc cagctcgacc gcatcagtga tatctttaaa cacacaaaga gccccgagca 2319601 gacgtccgcc ttcatcaata atcggcagtc ttgtggtcac aatttgcaaa tgatcgccta 2319661 acagctgctt ctggttgtat tcaggcactc ttgtttttaa aatccgcggc atcttagtgc 2319721 tcggaatcac ttcttttatt gggcgcccaa tgacttcctc acgttttttt ccgaccattt 2319781 tttcggccat atggttaaag agaatgattt cttcattgat atcaataaaa atcattccat 2319841 catgggtgga attaaaaatt ctgtcatatt tataggtttg ctcttttagc atttgaatca 2319901 ggtgctgctt ttcttccatc agctgaaaaa cgatgtatgc catttttccc ggcatgacaa 2319961 tggtatcttc atgctttctt tgaaggagct cgtcaaacac ggcttgatcg ccggtagtat 2320021 gaatgacgat atccggtttt tgttgtatgt aaggtttcca atcagatgat acggcaatcc 2320081 catactgttc tgcttctttc aatcccggcg cctcggggtc tttgtcaact acggcaatga 2320141 tatctatgat ggctgtttta atcagaatat gtaataacgc cgttcccctt ttgccggcac 2320201 ctactatcag taccttttgc atcccgatac ccctttgtat gaaaaaattt gcacacctat 2320261 ttattccgtt gcaataattt gcacaaccct atgttaccac gttttcttct cttgacaaaa 2320321 tattttttcc gctggacaat aaaggaaatg aaaagataaa ggggttttct gaagatgagc 2320381 cgacttcttg cgcttttaat attagtcatc cccggggcta tttctgcttt aggcattaaa 2320441 ctgatgagag atacactttt cggccataca atcaagccat tttcagctct ttggctccaa 2320501 gggttgtcag gattcatctt ttttgcgatc ggcctctatg tgctggccgg gttcatttta 2320561 tacagagaca gaaaacgcaa tcaagtcagc ccgcgattca gaaaacgata gctgaaaaaa 2320621 agccggagaa tgctccggct ttttttgttg cattattcgt caggcaaaac ggtcttggca 2320681 atcgttttgt ctaacgcttc atagtcataa taagaaatcg tatcgtacag ttcttttcgt 2320741 gtctgcatat catgaagtcc ttctttttgt gagccgtgct ccttcatcaa accaaacatc 2320801 cgctcacaag cttttgccgc cgctcgaagc gaggtgacag gatatatcac catgtgaaac 2320861 cccatatctt cgaattcatc ggcacgataa tatggcgttt tcccaaattc agtcatattc 2320921 gcaaggagcg gaacggggat acgctcagca aactggcgga attcattctc cgcctgtagc 2320981 gcttccggga aaattgcgtc cgctcccgcc tcaatgtaag cctctgaacg ttttattgcg 2321041 gcatcaagcc cttcctgcgc cctggcatca gtacgggcaa caacaataag ggagggtgcc 2321101 gcttgtttaa tggcttttat tttttgcgcc atttccttta tcggaactag ctgtttgcca 2321161 tttaaatgtc cgcatttttt tgggagctgc tggtcttcca tttgaacggc tgctaccctg 2321221 gcttcaagca tctcccgggc tgttcgggcg gcatttaaga caccgccaaa tcccgtatcg 2321281 atatccacaa gcaaaggcag atcagctgca cgcacaagat ctttggcccg ttcagctatc 2321341 tctgccgatg tgatgatccc taaatcaggc agccccctgc tggctgtata ggcagcaccg 2321401 gacaaataaa tagcagaaaa accggcttct ttcgcaagca aagcggccat cccgtcatgg 2321461 gcgccgggaa tttgaagaat gtccggtgct gacatcagct tgcggaaacg cccggcaagc 2321521 tcctcttgtg acgattgctt attgacgatc cacgacatga aacaaaatcc cccttttaca 2321581 tgcagaacat gtctacgaat tcatttacgc gcatcgtttg taatgtctca tagctggtac 2321641 agcgctcata aatgtgtttg tgctgtttat caggaaaatg ggttttgaga ttgtcagaaa 2321701 acttttccag cagtttcggc actgcttcct ctcttcgaaa acgatggccg aggggaaact 2321761 cacattccac catttccgtg ctcgttccat ctttaaaatg aacctgaacg gcatttgaga 2321821 tggagcgttt atcaggcttc aaataatcct cggtatatgt tttattttca gtcacttcca 2321881 ttttatcacg aagtttatct attctcggat cattcgctgt ttcagcttca taatgctgtg 2321941 cggtgatatc accaaaaagc aaaccgattg ctgtaatgta ttggaggcag tgatcacggt 2322001 ctgccggatt gtggagcggg ccttttttat caatgattcg gatagctgat tcatgcgttc 2322061 tgatgacaac tcggtcaatc tcgtcaatcc ggttctttac ctgcgggtga agaatgacgg 2322121 cggactccgc cgctgtctgg gcgtgaaatt ccgcaggata agacacttta aataacacat 2322181 tttccatgac ataagcgtcg agcggacggg caagcttgat ctctttctta ttgaataaaa 2322241 cgtcttggaa cccccaaccc ggtgcactca aggctgtcgg ataacccatt tcccctttta 2322301 acgacatcag cgccaaatga acacctctgc tcgttgcatc tcctgccgcc catgatttac 2322361 gcgagcctgt attcggtgaa tggcggtatg tcctcaatgc tgcattgtca atccatgcat 2322421 tcgaaagcgc atttttgatt tcttctcttc cgccgcccaa aagctttgct gcaacagcag 2322481 ttgtcgcaac tttgacaaac agcacatggt caaggccaac tcgatttaag ctgttttcta 2322541 acgccagcac accttggatc tcgtgtgctt tgatcatcat ctcaagtacg tcgcgtaccg 2322601 ttaacggctc ttttccttca gacagcctca ctcttgatac ataatcagca gcggcaagga 2322661 ttcctcccaa gttatcggat ggatgccccc actccgccgc cagccacgta tcgttgtaat 2322721 cgagccagcg aatcatgcag ccaatattaa acgctgccct cacaggatcg agaacatatg 2322781 acgttcccgg cactttgctt ccattcggca cagtcgttcc tggaacaatc gggccaagca 2322841 gctttgtgca ttccggatac cgtagcgcca agattccgca gcccagggta tccagcaata 2322901 catgccccgc tgttgtatac gcttcggcac tagtaatctc tttctcaagc acatagtctg 2322961 tgatttcttc gataacacga tccgttttcg gcattctacc agctcctttc atgattttgt 2323021 ttgatatcgc gggcccatgt aactgacacg gggacggaag agccgattat tggcatgctg 2323081 ttcgatcaca tgggcgcata aaccggacgt tctcgcgctg aaaaagatcg gcgtatataa 2323141 aggaatcggt atgccgagca tccaatacac tggggcagca tagtaatcca aattcgggta 2323201 aagccctttt tccttctcca tcagccgctc acccgcttcg cacatctcat ataaacgatg 2323261 gtcaccggct ttatcgcata attgctgcag cgcctctttc atcatgagtg ctctcgggtc 2323321 catttttttc atatacaccc ggtggccgaa gcccatgatt ttttcttttc ttttcagttt 2323381 tgtttgcaaa agctgctcaa aatcagatgt cgtttttgcc tccaaaagca aatacatcac 2323441 agcttcgttt gctcctccgt gaagattccc tttcagggaa gcgacagccc cagtcaaagc 2323501 cccataaaga tctgaatgtg tagatgcaat gaccctggcc gcaaaggttg aattcggcat 2323561 ctcatgctca ctgtacagga cgagcgaccg gtcaaaaatc tgttcttcca atgaagacgg 2323621 caatttccct gtcatcatgt agagaaaatt cgcactgtag gatagggttt gaagcggaag 2323681 aatcggttct ttcttattaa tgatcctgta gctggcagca gtgagggcag gcattttccc 2323741 aagaagctga taggcgcgtt ctttgtttgc ggaaggagac cgatcatcaa tttgccgatc 2323801 atagccagca agtgccgaca ggccggtacg cagaccatcc attggatgag tgtcctcagg 2323861 gagcagctca agcagacgga gatgatcagc aggcaggctt gaggcactgt ttattttacg 2323921 ttccagcgtt tccatttcac tttcttctgg cagcctgccc tccagcaata aatggacaag 2323981 ctccagatag ctttttgttt cagaaagttc tattaaatca tagcctctta tcaaaatctg 2324041 gctggactgc gtgtcaagat aagaaatatg agtttctgcc gcaatcacac cgtccaaccc 2324101 tggagaataa tgctgtttct cctccatatc ctcaacctcc gtttttgcgt tttttgtcta 2324161 tcaggttccg ccaagcaaat acttggaaat aatcagtctt tgaatctcgt tcgtcccttc 2324221 ataaatttgc gtcacctttg catcgcgaag caggcgctca actggataat ccttcatata 2324281 gccatatccc ccataaattt gaacggcgtc taacgccgcc tttacggctg catcggaagc 2324341 aaattgttta gccatagacg cttcttttcc acagtttagg ccgcggttat gaaggtctgc 2324401 agcgtggtag acaagatgtc ttgccgcctc agctctagtc gccatatcag ccagcttaaa 2324461 tgatatgcct tgattggctg caatcggcct tccaaattgc actcgctgct tcgcataatc 2324521 aacggcatgc tcaagagccg cctctgcaat tccgagggcc tgtgccgcaa tgccgatccg 2324581 gccgacattt aaattcgcca tggcaatgtg aaagccatcc ccctctttgc caagcaaatt 2324641 ggcttcaggc acttctgcat tatcaaaaat cagttccgta gtattggagc cataaagccc 2324701 cagctttctt tctttttttc caacggtaaa accgggtgtg tttttttcaa caataaaagc 2324761 cgaaatcccg tgcctgcctt gatctggagc tgttaaagca aatgtgatat agatatcagc 2324821 tgctccgcca ttcgttatga atattttcga tccgtttaat aggtatttgc cgttcttttt 2324881 gattgctgtt gtgcggaggc tcccggcatc cgaccccgag tgaggctccg ttagtgcaaa 2324941 tgcgcccaaa tggtctcctg acgcgagatt tggtatatat ttcatcttct gttcttcgtt 2325001 gccgaaatac agaatcggat tcgtgccgac tgaggtatga acggagagaa tcacgccgac 2325061 agccgcgctg attctagaaa tctcatgaat tgccaaaata taagaaacaa cgtccgctcc 2325121 agcaccgccg tattgttccg gcaccggtat tcccatcagt ccgtgtttac ccattttttt 2325181 gatcagctga aagggaaatt cgtccgtttt ctccatgatt tccgcagcgg gagcaatttc 2325241 ttttcgtgca aaatcacgca ccatttttcg catcatgact tgctcttggg ttacatgcaa 2325301 ctcggccacc cccggatgga atagacttca ggaagtcttc tcctcatagt cataaaaacc 2325361 gcgtccgctc tttttgccaa gccagcctgc tttgacatac ttgcggagca gcgggcaagg 2325421 acggtatttg gaatcgccaa ggcctgagtg aaggacttcc ataattgata aacacgtatc 2325481 cagtccgata aaatccgcta atgcaagcgg acccatcgga tgattcatgc ccagcttcat 2325541 cacttcatct attgcctccg gcttcgccac tccctcatac acgcaataga tggcttcatt 2325601 aatcattgga agaagcacac ggttggaaac aaacccagga aaatcattga cttctaccgc 2325661 tgttttcccc atcttttccg ctaatgccat aacatctaag gccgtttctt ctgatgtagc 2325721 caagcctcga atcacttcta ccagcttcat tacagggacg ggattcataa aatgcatgcc 2325781 aataacccgt tgaggccggt ttgttacagc agcgatttct gtaataggca aggaagatgt 2325841 attgctggcc aaaatcgtat gaggcgggca aatgcgatca agtgttttaa acatctcagt 2325901 ttttgccgcc atgttttctg cgatagcctc aatcacaatg tccgcatgct ctgcctcctc 2325961 aagtgtttga gaaatcgaaa tgcggttgat tacgctcttc acttccgtct cggtcctttt 2326021 tcctttctca gcatcacggg ccagctgttt cttcagccgt ttcaatcctg cctccgcggc 2326081 ctctggattc acatcataca tccgcacata aaagcccgcg tcggcggctg tttgagcaat 2326141 tccgctcccc atctgacctg cgccagctac catgatttgt ttgatttcca ttcaaatccc 2326201 ctttttcatc atgttttaat gaacctgcac taagacggcg tctccctgtg ctgccccgct 2326261 gcaaatagcg gcaacgccca gaccccctcc ccgtcgcttt aattcataaa caagcgtcat 2326321 gagaattctc gcaccgctcg cgccgatcgg gtggccgagc gcgatcgcac cgccattcac 2326381 atttactttt tcaagatcga aacctacgat tttttcacat gtcaaaacaa ctgaagcaaa 2326441 agcttcattt acttcaaaca agtcaatatc ttggacagtt aaaccattct ttttcaggag 2326501 cttgttaata gcaaaccctg gcgctgccgc cagctcgtgc gctggcattc ccgtagttga 2326561 aaaaccaaga attgtagcca gaggccgttt gccaagctca gcagcttttt cctcagacat 2326621 cagcacgaac gcgccggctc cgtcattgac tccaggagca ttgccggctg tgatagaacc 2326681 gtcacttgca taaatcggag caagttttgc gagctgatcc agacttgtgt cacggcgaat 2326741 cgcttcatct ttatcaacaa cgtttggttt tccttttcga ccgatccagt tgacgggaac 2326801 aatttcatcc tgaaacttcc cttcatcggc ggccttagct gcccttgcat gacttctcaa 2326861 cgcccattcg tcctgctctc ttcgtgagat tgcatattcc ttggcagctg tatttccgtg 2326921 aacagccatg tgcacctcgt caaatgcgca cgttaatccg tcatacacca ttaagtccct 2326981 aagctcgccg tcccccatcc gtgctcccca gcgcccggcg ggaacggcat acggaatatt 2327041 gctcatgctt tccatccccc ccgcaacaag tatgtccgca tcctgcgccc gaatcatttg 2327101 atcacataaa gtgacagcgc gaaggccgga agcacagact ttattcagtg tttctgacgg 2327161 cacactccaa ggcattcccg ccagacgggc agcttgacgg gaaggtatct gccctgagcc 2327221 ggcctggaca accatgccca tgacgtttcc ttctacatca tctccagaga ctccagcctg 2327281 ttgcagcgcc tccttcatca caatgccccc aagctcagca gctttcacct ctttcaaaac 2327341 tccgccgaat ttgccaaatg gagttcttgc agcacttaca atgactgttt tcctcatggt 2327401 ttcacctcat tcagaagata gacagcgctt acaatttcta gttgtcttct atgaatgtat 2327461 gctttgaaac gggcatgaat gaatgaaaaa agaaggctgc gtcaaacagc ctccttctaa 2327521 caactattca tttttcagca atgccgaagc cttttctgga aagtcggtaa acatgccgtc 2327581 tgctcccgct tcaatgagac gcttcatatc ttccggacga ttgactgtat acggccttac 2327641 cttaatcaaa ccgttcctca ttttcttcag tacttcatct gtgacccctg ggctgtttat 2327701 cttcgggtga tagccggaag ccggaataga cgcgatatat cgatctgcct gataaagcac 2327761 atctgaagtt aatactgccc gttcgatatg cggtgcaagc cgggcgcaca gcgccaagct 2327821 gtcatgatta aacgtggata ggatgactct gtcctctaca ttaaatcgct tcactgcctc 2327881 cagcactttt tcttccattc cctcatagcg gatcacgctg ttttttaatt caatgttgat 2327941 gagaaaatcc ttttttaccg cccacgagag cacatcttct agcagcggca cttttatatc 2328001 gctgtacgct tgatcgtgac cagcggccgc attcgcagtc tttacctcat cataggctgt 2328061 atccttcacg aatcctttaa gtgatgtcgt gcgattaagt ctttcatcat gaattacaac 2328121 aatgcgtccg tctttcgtca gctgtacatc aagctctatc ccatccgctc cggcttcaat 2328181 tcctttttca aatgcaagca ttgtattttc gggaaattga cctgatgccc cccggtgggc 2328241 aaaaatcttt gtcatcgttt cacctcaaac cctaaagttt tctccattat acttattttg 2328301 tcggctccac tctaggatta aggctgtatc aatctactga tcataataag aatcaatgcc 2328361 attgacaatc gcatctgcgg ccttttgctg gtattcttca cttcccagct tgtccgcgtc 2328421 agagctgttc gtgataaacc caagctccgc caacacactt ggcatttgtg aatatgtaat 2328481 gacgtaaaag tctgattctt tcacgcccct gtctctcgtt tgtaaggaag aaacgagctg 2328541 tgactgaata tcggatgcca gacgccggct gttctcccct tcataatcag attgaaaata 2328601 cgtttctgtt cctgaagctg aagcaacccc tgaattcaca tgaatgctga caaaaaggtc 2328661 agcctgattg gcacttgcct tagccactct ttcctccaag gtcagaaaat gatcgtcaga 2328721 ccgggatgca acaggattgg ctccctcctc ttttagtttg tctgtcacat gctctgagac 2328781 agccaaatta atatcctttt caaagagccc gtttccgacc gctccactgt cttcaccgcc 2328841 gtgtccggca tcaatataca ctgttttccc ttctatcggc tctgctgcct gtgcacaagg 2328901 cgcgagcgtc aaagccaatc cgcacagcgc caagctcctc cataacattc tcaacttact 2328961 ccctccggtc acgagttctt tcgcagctga atatcttcca gctgtaaagt tccattatcc 2329021 ttctttgtat atttcaccag gacatgtgtc tgatctggca gtgattcaca ttcatcacgt 2329081 ttatccttcg gaacttgtat catggtttct tctccattaa gagaaaccgc aatcgtatga 2329141 ggatcagccg agccaatgta ttttccctct tcggtaaacc tcggcactga gtcatccgca 2329201 cttgcaacac tgcaccccga aagaaagagc gcagtaaaca gcaaaagaac cgtttgtttc 2329261 acatgaccac ctcttcctga tgtttggctt ttatctttga ccagaatgga gaatttgtaa 2329321 agacaacgcg aatgcaggcg agcaagttcc atgattttca aaagggctat acgacccgat 2329381 catttcctgt tgttagaaag ataacgagca gatttgtcta tgaggatggc tctaattgag 2329441 gcgccaatta gaaaaaatta gcggaaagaa gcaacttttt attcatttta aaaaatttga 2329501 gaatagggtg agcaaatcgt ttgacgggtg ggtcagccaa gcgtaacctt ttaaaggata 2329561 tttactttat tgaaagaagt taaagccatg aaaaaattcg ttctgctgct ggcggcagct 2329621 gtcatcacat gctccatcgg ccaccaaatc agtggcggct acaaaggccc cgaaaaagag 2329681 cggccaaaac atcactctgc actcaagata ttcagtcggt aaagcagatc aattgcatta 2329741 atttttacat ataggctaga atatgtgcga atccaaacga aagaagatga tcaaatgaat 2329801 cctaagtata agccactttt tgaaccattt acgtttaaaa gcggcgttac aatcaacaac 2329861 cggatcgcag tagcaccgat gactcattac gcttctaatg aagacggtac aatatctgaa 2329921 gcggagctcg actacatcat cccccgttca aaagagatgg gaatggtgat tacagcctgc 2329981 gcaaatgtta caccggacgg aaaagcattc cccgggcagc cggccatcca tgacgattcc 2330041 aacattccag gtttaaaaaa gttagcacaa gccattcagg cacaaggcgc taaagctgtt 2330101 gtacaaattc atcacggcgg tattgagtgc ccgtctgagc tcgttcctca acaggatgtt 2330161 gtggggccaa gtgacgtgtt tgataacggc aaacaaattg ctcgcgcatt aacagaagaa 2330221 gaagtggaaa acattgtgaa ggcgtttgga gaagcgacaa gacgcgccat tgaagccggc 2330281 tttgacggtg tcgaaattca cggtgcaaac ggctacttaa ttcagcagtt ttattctccg 2330341 aaaaccaacc agcgcacgga tcgctgggga ggaagcgatg aaaaacgatt agccttcccg 2330401 ctcgctattg tcgatgaagt gaaaaaagcc gcttcagaac atgcgaaggg tgcattctta 2330461 gtcggctacc gcctgtctcc ggaagaacct gagacaccgg gattgacaat gactgaaact 2330521 tatacgcttg ttgatgcttt aggggataaa gaattggatt atcttcatat ctcactgatg 2330581 gacgtgaact caaaagcgcg ccgcggtgca gatccgactc gcacacgcat ggacttattg 2330641 aatgaacgtg tcggaaacaa agtgccgctg atcgccgtcg gttccatcca ttccgctgat 2330701 gacgcgcttg ccgtcatcga aaacggtatt ccactggtcg ctatgggacg cgaaattcta 2330761 gttgacccta actggacggt aaaagtaaaa gaaggccgtg aaaagcaaat cgaaacagtg 2330821 atcaaaggca cagataaaga aaaatatcat ttgcctgaac cgctatggca agcaattgtg 2330881 aacacacaag gctgggtgcc ttataaagat taatgtgcaa agactgccga aacgattcgg 2330941 cagtcttttt tccctttata taaatagttt gtgtacacat ctaaacagca aaagaaagag 2331001 ctccccacca acttcgaaaa gaaaatccag gaaaaacccc tcacgctttc ttgctttttt 2331061 ctttttcatt cgtacgtctc ctttttacat gaatacgcct tacttacgat tttgcaggag 2331121 aaaggtttca ttttataacg gacacatcta gggtcgatca tgcttcgtga tcctataaga 2331181 tgtatgaatg gaccaagagt gcaggtaata ccgccatttg ctttccttac ttttcaaacc 2331241 tatcctttac tatatgcgga tacttaatat tcttctccca tactacaaat gtccccaaaa 2331301 caaaacgcct cctatttatc agcgcaaact aataaataaa agacgtttga tttaatgacc 2331361 acttaataag ctcatgttta agaagcctta tgctctaacc tcagcttatc cgcaaccatt 2331421 gcaatgaatt cactgttggt aggtttagct tttgtcatgc tgacagtata accaaacaac 2331481 gaggaaatgg aatcaatgtt tcctctgctc catgccactt caattgcatg gcggatcgct 2331541 ctttctacac ggcttgcggt tgtgttaaat tttttggcga tgtccggata gaggactttt 2331601 gtaatgctgc cgagcaattc gatgtcattg tataccattg agattgcttc gcgcagatag 2331661 agatagcctt taatatgggc tgggacgccg atttcatgga taatgcttgt gatgctcgcg 2331721 tcgagatttt tcttctttgg ttcaggctgg ctgctgcgta taatactgct ttgcgatgat 2331781 ggcgcacgat gcgtcacact gctggcattt ccgctgacct ggcggatatg gccgacaagg 2331841 ttttccatat caaacggttt gagaataaag taggacgcgc ctaaatcgac ggcctttttc 2331901 gtgacatctt cctgcccaaa ggctgtcagc ataatgacat tcggctgttt tttcagatct 2331961 gattccctca gcctctctaa aaccgcaagt ccgtctagat gcggcataat aatatctaat 2332021 acgagcacat cgggatcttt ttctttaaac agcgacaggc attcctgtcc gttataagca 2332081 acgccgatca cttccatgtc ttcctgtcct tctatatatt cacttaacag gcttaccagc 2332141 tctcgattat catcagcaac acaaacttta attttctcca cgtttcttcc tccccaaatg 2332201 tagttaacag gattcaccct tgctacatgt ttacattcga caaaaccgct atataccctc 2332261 taaaaaaatc ataatcacca atattagtgg catatctttg ttattctatg tttttctctg 2332321 tttttcgact aaaaatgaaa tttgacaaac aaggaaacgt gaatttgtcg aaaaatcttc 2332381 ttttgtatat tttaccgtat gtattctgag aagtgaagag ggatcaaaat aaaaaaactg 2332441 ccggaaactc cggcagtcag cttgcttttt cttttccata aatatcgatt cctgcttctg 2332501 acagcatcca ttcaatatga acaccgtagc cgcttgtcgg gtcatttaca aatacatggg 2332561 tgacagcacc gatcactttt ccattttgaa tgatcgggct tccgctcatc ccctgtacga 2332621 tgcctcctgt ttctttcaac agtcttggat cggtaatttt caacaccatt ccttttgtcg 2332681 cagggaattt ttgcggcgtt gtgctgacga tttcaatatc gaatttttct actttgtcat 2332741 catcaataac cgttaaaatt tcagccggcc cttttttgac ttcggtagaa aacgcaaccg 2332801 gcaatgcttg atctgatatg ttgttttgaa tcggctgatg cagtgtgccg aaaatcccaa 2332861 acgggctgtt tctgttaata tccccgatcg ttttgcgttc tgaggaaaat cgcgccagtt 2332921 tttctcccgg attaccgcct gtcccttttt caattgatgt tacagtggat ttaacgattt 2332981 ctccattctc cactacaatt ggtttctttg tgtccatatc ggaaatcacg tggccaagtg 2333041 ctccgtattt ttttgttttc ggttcataaa aggtcatagt gccgatgcca gcagcagaat 2333101 ctctgatata taacccgatt ctgtatttgc cttctccttc atccttttct gggatcagct 2333161 tcgttttgat tttctgttta tcacgtttga tcagtaagtc taaagattca ccagttttcc 2333221 cagccttttg aataaatggg gctacatcat tcattttttc aattttctgt ccattcatct 2333281 caataatgat gtcgcccgct tcaattcctg ccgtttctcc cggagatttt ttgccttcac 2333341 ttgtattgat ttgatgaaat ccgacgacaa gaacaccgac ggaatgaagt tttacaccga 2333401 ttgattgtcc gccaggtata acttttaaat caggaagaac atgcactttt gtttttttaa 2333461 ttggaaatcc ggcaagatca tataccaatt ctgactcacc tgattttttg cccgtcacct 2333521 tgatttcatg cggatctttc tttactgtaa acgcttctga ggattctgat gtctgagcgt 2333581 ttaccgataa actcgtttca atcgcttgtg tttgggtttc aaatactctc atttgcgttg 2333641 gaatcagtaa atattctttt agcggtttgc ataaacctac acttaataac gaaacaagga 2333701 gaattaaacc tactgctttt ctgatgttat cgggcattca ctacttcact ctcctcgctc 2333761 ctatcccaca ccttctttat gacttgctgc tacatcattt aattttgcct tctgacggct 2333821 tatttataac tgtcatatga agaaaaacat tggatatact gatgaacgaa tggatgtgca 2333881 cgaaaaaaat aagctgcgct tctcgcgcag cttacccagt tgttttgact tgatccgctt 2333941 gttttaaaag ttctttcgca tggcgtttcg ttaagtcggt tacttcgaca cctgcaatca 2334001 tgcgcccgat ttccgctacc ttttcctgct tagagagcgg cttgacacgt gtcgtcgttc 2334061 tgccgtcttt taactccttc gcaatataaa gatgcgtatc ggccatggca gccacctgag 2334121 gcaggtgtgt aatgcacagc acttgtgatc ctattgacac cttatggatc ttctcagcaa 2334181 ttgcctgtgc gaccctgccg cttacaccgg tatcaacctc gtcaaaaatg atcgatgtca 2334241 catcctgttg tgaggaaaaa atgcttttta tggcaagcat cacccgtgac agctctccac 2334301 ctgaagcgac tttcgaaagg gatttcagcg gctcgcctgt attggttgaa attaaaaact 2334361 tcaccaggtc aatcccttgt tcagtcagct gaacgggctg gccgtttaca agcggcgcct 2334421 cttcattgcg tgacgctgtt ctgaccttaa attccgtatc aaaagttgat ttttccatgt 2334481 acaggctttt taattcccga tgaatctcat cagccagctt tttcgcccat gtttttcgga 2334541 tttgtgacac atttgccgct tccactgcga catctttgcc gacggagtca agctcctttt 2334601 tcaagctttg aaggtggctg tccctgtttt caatttggtc aatctcttct tcaattttag 2334661 aagcatattc caaaatgtct tcaacagtgg caccgtattt tcgtttcagc tgtttgattt 2334721 cattaagtcg cgtctcaata tagttcaggc gttccggatc aaattcaagc tcatccagca 2334781 tatttctcat ctgaaatgtg gcatcctcaa gcaaatagta ggagttcgaa acactttcag 2334841 acattttttt cagcggttcg tttatatcag atatatcttc aagctgcgct gatgccattc 2334901 caacccagtc caatccgccc tgctcactgc gaagcgcgtt atatgcattt tgcagcgact 2334961 catatatctt ctcaaagttt gaaatttgct ggcgctcttc ttggagctgt tcatcttcgt 2335021 taagctcaag ctttgccgat tcgatttctt cgagctgaaa ttgaataaga tcaagacgat 2335081 gggccatttc ctgttcgctt tcagaaagct gcttaagctt tttgagcagc ttcacatacc 2335141 gctggtaccc ttcctgatac gttttgagcg cgctttccac ttcggccccg gcaaacttgt 2335201 ccaaaagctg gagatgattt tcgtcttcca ttaacagctg gttatcgtgc tgcccgtgaa 2335261 tatctaataa aagcctgccg atctctctta gtgaagcaat cgtgacaagc ttgccattga 2335321 cacggcaaac gcttttcccg ctcgtgctga tatcccttct catgacgatc atttcgtctg 2335381 aaacgtcgat tccctgctca gcgcatacgc ctaaaacagg atggccgctc tccaacagaa 2335441 acagcccttc aagttcggct tttgcttccc catatctaac aaattcagat gatccgcggc 2335501 ctccgactaa aagagaaatg gcatctatga tgatggattt gccggctccg gtttctcctg 2335561 ttaaaaccgt aagcccgcgt tcaaaagaaa ccgtcagttc ctcaataatg gcaaagtttt 2335621 taatcgatag ttcagctaac aaacagcatt acacctctta tctttgttag attttctgtt 2335681 acagcagttc aaggagcctg ttttttacgc cttctgtatc ttcaggagtc cggcaaataa 2335741 ttaaaatcgt atcatctccg caaatggtcc ccatcatttc atcccagtcc aaattgtcca 2335801 tcagcgcccc gattgcctgg gcattgcccg gcatcgtttt cagcacaatc atatggcttg 2335861 ctgagtctat tttcacaaat gcgtccatca atgcccgctt tagctttgac agcggattga 2335921 aacgctggtc cgccggaaga ctgtatttgt aagaaccatt atttgtaggc acttttacaa 2335981 ggtgaagttc tttaatatcc cgtgataccg tggcctgcgt tactttgtat ccatcctgct 2336041 ttagcatgtc gaccaattca tcctgcgttt cgatttcatt gcttgtaatg atctctctga 2336101 ttttaatatg cctctggcct ttgttcatgt aagcacctct atttccaagc ttatctgttc 2336161 ttttatgtta tatgattctc tgcacattgt acatgaatgc agaaaaaagg aataatagcg 2336221 ccctattatt ccggtacatc tgcttttttt tcttttaacg tcttatgtgc ttcttctaca 2336281 acgcgcatga tctcttcttc cggcagttcc tggccttcct gtccctctcc cggccaatgc 2336341 aaatgaagga gaaactcaat atttccgtct cctcccgtga ttggagaaaa tgacaagcct 2336401 ttacagatat agccttcagc ggcagaaaaa ctgatcattc gcttgagcac atcagcatgc 2336461 actttaggat ctctaacaat cccttttttg ccgacggatt cccgtcccgc ttcaaactga 2336521 ggcttaacta aagccatgca gtcgctgccc ggtacgagca aagtccttag gacaggcagg 2336581 atgagccgca gtgaaataaa ggacacatca attgtggcaa actccggcat gccctttgta 2336641 aagtctgccg gtgttgcata acgaaagttc gtccgttcca tcacgacgac ccgttcatcc 2336701 tgtctaagct tccatgcaag ctgattatag cctacatcca cagcgtatga ctgtttagct 2336761 ccattttgca aagcgcagtc cgtaaaaccg ccggtggagg agccaatatc aatcataatt 2336821 ttatctttga cagagacggg aaattccttc aacgcttttt cgagctttaa gccgcccctg 2336881 ctcacatacc tcagcgggtt tcctttgaca gttaacggaa ggtcgcggtc aattttttct 2336941 ccaggcttgt ccaagcggtt ttcgtttgaa tagacgatcc ccgccataat ggctcttttg 2337001 gctttttcac gcgtttccgc cagccctctt tccactaata atacatctaa tcgttctttc 2337061 tttgacgtca tgatccaatt cctttgtgtg tctttggtgg catcagtaat ctaatacgat 2337121 ttgccacctg ctgttttgtc agtccaattt cctcaagaag cgctgttaca cttccgtgtt 2337181 caataaaccg atcaggtata cccattctgt caatcggagt atgatattca ccttgatcat 2337241 gagcgaattc taaaatcgag cttccgaaac cgccttctaa gaccgcttct tcaattgtta 2337301 aaattggcaa gccttctttt aggatactct tcatcatctt ttcatcaatc ggcttaataa 2337361 aacgcgcatt cacaacgcgc acggaaaggc cttctttctg cagctcttcg gctgcttcaa 2337421 tcgccatttc gattgttgtg ccgaatgtta agatgacagc atcgttccct ggacgcagca 2337481 cctcccacgt accgatcgga atcgttttca actgttcatc catttttacg ccgagtccgt 2337541 ttccgcgcgg aaaacgcatt gctatcgggc cttcgtcata gctaagtgct gtatgaacca 2337601 tgtgctggcc ttcattttcg tctttcggca tcattaagac catgtttgga atgtggcgca 2337661 taaacgcaat atcaaacacg ccttgatgtg tctctccatc agcgccaacg agtccagcac 2337721 ggtcaattcc aataaacaca ttagcgtttt ggcggcagat gtcatgaaca acttggtcat 2337781 atgccctttg caggaaggtt gagtaaatcg ccaaaaacgg cttcataccc tgcattgcca 2337841 tagctgcagc cattgttgcg gcatgctgtt ctgcgattcc tacgtcgaac atccggtcag 2337901 ggaattcctt tgcgaagcct tcaagctttg aaccgacagg catagccggc gtaatggcta 2337961 caatgcgtcc gtcctcgcgc gccattcgct gcacagttcc gctgacaaga ccgctccacg 2338021 aaggagctgc ggctttcggc tttacaaagt caccggtatt aattttatat ggtccggtac 2338081 catgccatgt cccaatcgta tcggtctcag ccggtttgta ccccttccct tttttcgtaa 2338141 tgacgtgcag aagaacaggg cctttcgttt ttttggcgta ttgaagattc tcaatcagct 2338201 catgataaga atgtccgtcc actgggccca aatacgtaaa accgagctcc tcgaaaaaca 2338261 ttccggagac gagcatgtat ttcaggctgt ctttgacccg ttccgccgtg gcggcaagct 2338321 tgcccccaac tgccggaatc tttttaaata agtattcaag ctcatctttg acccactggt 2338381 atttccccgc agtgcggagc cgtccgagca tagagtgaat ggcaccgacg tttggcgcaa 2338441 tactcatttc attatcatta aggatgacaa tcatgtcttt tttctcgtcg ccgatgtggt 2338501 taagggcttc gagcgccata ccgccggtca gcgcgccgtc accaatgatc ggaataatat 2338561 attcatccgt tcctttaata tcacgggcag ctgccattcc catcgcgcct gacagagaag 2338621 tcgagctgtg cccggtttcc caaacatcgt gctcgctttc actccgcttt ggaaatccgc 2338681 aaagcccttt gtactggcga agcgtcgcaa attcttttcc gcgtcctgtc agcagcttat 2338741 ggacatacga ctgatggcct acatcccata aaaatttgtc tttcgggctg ttaaattcct 2338801 tatgcagggc aacagtaagc tctacgacac ctaagtttgg gccgatgtgg ccgccggaag 2338861 cggataaact tgtaattaaa aactgacgga tttcatcact taatttctct aattcatcaa 2338921 tggacatgtt ttttaaaaac gacgggtcct gtattgataa aagatccaaa gcggatcaac 2338981 tcactttcag catgaatttc tgcaatgata catgtctttt gcatgccgag ctgacaataa 2339041 tctcagacat aaaaaaagac aaacgcgctt ttccttttca tttttcatat aaactgctta 2339101 cattttacca tacctcgtgc agccgcttca aattaggatc gttttagtga tctcttgccg 2339161 caattaaatc acaaagctca tataaaaggt ctttttgaag agagagtccg ccgatcaatc 2339221 gcttcgcctc ttttatatga acatccaatt tatgtttggc cccttccaat gaaagaagcg 2339281 acgggtatgt cgatttgtca tttgtggtat ccgagccgac acgtttgccg attttctctt 2339341 cactgccttc taaatctaaa atatcgtctc tgatttgaaa tccgattcca atgtggctgc 2339401 tgaaggtacg cagtgtttca atgtcttcct caggcgcatc agccaaaata gcaccggcga 2339461 ttacacaaaa gccaaggagc ttggcagttt tccgttcatg aatggattcg agctcttcaa 2339521 gcgtgacttg tcggttttcc gcttccatat cagctacttg cccaccgacc atgccttcgg 2339581 tgcctgccgc tgaaatcagt tcattcacaa gccgcaggcg cttttctgct gacacctcgt 2339641 ctgacacgtg ggaggtaatc agcttaaagc tttctgtgag cagcccgtca cccgctaata 2339701 ctgccgtcgc ttcaccaaac actttatggt ttgtcggctt cccgcggcgc aaatcgtcat 2339761 catccatgca tggaagatca tcatgaatta acgaatacgt gtgaatcatt tcgacagcac 2339821 agcccaccgg aatgccgtct ttttcgcttt ttccatatgc atttaaaaca gccagtacaa 2339881 tcagaggccg caaccgcttt ccgccggcct gtagagaata tagcatagat ttctttaatg 2339941 agtccggcat atcaagcttt tctgtataga cagaaagctg attttcaatt gtttttttcc 2340001 ggtccgccag aaagctcgtt aatttatttg tcaccttcgt cttcctcctg aacactgaaa 2340061 ggtgccagtt cgccgtcttc ttttaaaatg aagtccattt gcttttcgac tttttgcagc 2340121 ttttcatggc acatttttga cagagccatg ccttcttgga aatagttaat ggcttgctct 2340181 agaggcacat ctccctcttc aagctttgat acaatgctct caagcccttt catcgcttct 2340241 tcaaatgtca tgttttcatt ttttttcacg tctgtcattt ttcttcccct ctcttttcta 2340301 atacttcaca ggtcagcacg ccatccttca gcttgatttc aagccggtcc tgctcttcta 2340361 tttgactgac acttttaatg agtttatctt ctttataagc caagctgtat cctctttcca 2340421 tcacttgaag aggacttagt gcattcagct tgccaagaac ggtttgaaat tgggaatgca 2340481 gctgcttcat ttggatattc atattttttc tcagctgatt tgtttgttcc tggtatcgtg 2340541 ttctcgcttg tttcagctgt tcatgaggat gcaatgcctc taatctgtac gtttcacgct 2340601 ccagctgtct gcttttccga tctaaaagag cggtcagctg tgcttgaaac tgctggtacg 2340661 cgaggtcaaa ctgctgctct ttttgcgcat acaaacgctt tggaaaacga aaggcatagg 2340721 acgattgcag cgtttgtatc cgttcttttt tctggccgag atgctgctgc attgctcttg 2340781 tcattctgac ttccgctgtt tttgtccgtt cgattaaatc agtggtatga ggcacagcaa 2340841 tctcagctgc tcctgtcggc gtcgcagctc tgatatcggc gacaaaatca ctaatcgtaa 2340901 aatccgtctc atgtccgact gccgatataa tcggaatatt ggaagcaaag atggcgcgtg 2340961 ctacaatttc ttcattgaat gcccacagtt cttctatcga accgccgcct ctcccgacaa 2341021 ttaatacgtc gcaaatctct ttttcatttg cctcttcaat gcgcgtaacg atggatctgc 2341081 tcgcattttc accttgtacg agcgctggaa gaacaatgac ttttacaagg ggatatcttc 2341141 tttttagagt tgtaataacg tctctgacag cggcacccgt tggagatgtc acaaccccga 2341201 ttgtggctgg aaatgcgggg atttgttttt tgtagcggtc gtcaaataaa ccttctccgg 2341261 caagcttctt ttttaattct tcgtacgcta aataaagcgc tccaaccccg tcaggctgca 2341321 tttctttggc atataattga tagtttccgc tcggttcata tacggaaatt ccgcctctga 2341381 ccagcacttt cattccgttt tcaggtttaa aaggcagacg ctcgctttgt ctcgcgaaca 2341441 tcaccgactg cattcttgcg ttttcgtctt ttaaagtgaa ataaatatgc cctcgtgtgt 2341501 gtatctttac attcgacaat tcgcctttaa tccaaatatt ttcaaggtga ggatctacat 2341561 cgaattttcg ttttatatac tttgtcagcg ctgagacggt cacatacgct gcttcaccca 2341621 tgtctaaaaa ctcctctcct aagcattcct gcaccataac taaagaaaac ccgccctggc 2341681 tttaggagcc tgaagaagcg ggtatcgtgc tcatattcaa ggcgggtaaa catttcgcct 2341741 gtgaatatct ccaattatct atgataacgt acgtttcgca gatttaacag tattatgcgc 2341801 aagcatcgtg atggtcatcg gacctactcc gcccggaacc ggcgttatga aggacgcttt 2341861 ttcctttgcc ccttcaaatt caacgtctcc gcaaagcttt ccgttttcca gacggttaac 2341921 gccgacgtca atgacaacag cgccctcttt gatctggtct gcactgatga agttggctct 2341981 gccgactgcc accaccagga tgtccgcttt tttcgtatgt tcagtaatat tttctgttct 2342041 tgaatgacag taagtaaccg tcgcgttttc atttaataaa agctggccga caggtttgcc 2342101 gacaatgttg cttcggccga ctacaacaac ctctttaccg gaaaggtcaa tattggtttt 2342161 cttcaaaagc tcaacaattc catgaggcgt gcaaggaaga aacgtatctt cgccaagcag 2342221 cattttccct acgtttaacg gatgaaaacc gtctacatct ttatcagggg agatacgttc 2342281 gatcaccgct ttttcagaaa tatggtctgg gagcggaagc tgaacgagaa tgccatgaaa 2342341 ctcagggtct tggttatatt gatcaataat ggaaagcagt tcagcttctg tgaggctgct 2342401 gtcaaattga tcgagcttga aattcattcc cattgtttct gccgcttttt tctttcctcg 2342461 cacgtaagag tgagaagcag gatcatctcc aatcaaaata accgccagtc cgggagtgac 2342521 gccttgcttt ttaagctctt ctacctcttt tgccaattgt tcgcgttttt ctctagccgt 2342581 ttcttttccg tcgatgattg ttgcagtcat tttctttcct cctatgattg ttcaatatca 2342641 gatttaatgt tagaaagaac cccgtttaca aactttgtcg ctttgtcatc accaaaccgt 2342701 tttgccagct caatcgcttc gttcatggag acattcaccg gaatgtcttc ggcatatgcc 2342761 atttcatatg ctgccaggcg caaaatcgca cggtcaacat tggcaatccg atcgagcttc 2342821 caattcacca gatgcttgga gatcatttca tccagctggt cttggtgttc caataccccg 2342881 tgtacaagct gttcaaagaa aggatctgtt ttttcttcat ccagtgcgtg ttctatggct 2342941 tcattcactg caatatcgct gacatcaatt tgaaatagtg cctgcaaagc tttttctctt 2343001 gctgttcttc ttttcatttt ctttctcctt tgatcctctt tatccgcttg tcgttaagcc 2343061 acaaagagat cataacatat ttttttcgta tccgcatatt gaaatcaagg tttttttacc 2343121 ctattaccga atattttcac acaccttaat atgattattc ggatttcacg ttcatgaaga 2343181 aactcggcta tgtaagccgg ctttcttcat gctttgaaat aaagggtaac gtgtaaaaaa 2343241 accaaagggc cgccctcccc ttggtttcgt gttaagccat ttacatttct tcgtcgattt 2343301 ggacttcttg ggcttttgtg tcaaattgaa tgccgacgat gtgaatattg atctcgttaa 2343361 tcgaaagaga cgtcatattt aataaggttt gacgaatgtt ttcctgaacg gatgctgcaa 2343421 ctttcggaat cgaaacgcca aatgtaacga cacagtatac atcgatcgta attccgtcat 2343481 ccgccaggtc gactttgaca cctttgccat gattcacttt gccaaagcgc tcaacgacgc 2343541 ctgtcgcaaa gtttccgcgc atttcggcaa ctccatcaac ttctgatgct gcaatgccgg 2343601 caatgacctc aatgacctcc ggtgcaatct caaccttacc caaatgcgta tcttcgtgat 2343661 ccattttaag caagctgttg tctttcattc aattcacctc cgtaaaaatt atgagcccat 2343721 tacatcatat gtttctaaaa atttcgtatt aaactctccg ctcacaaatg tttcgtgttc 2343781 aagcagtttt aaatggaaag ggattgttgt ctcaatgcct tcgatgacga attcgctcaa 2343841 tgcgcgcttc atgcgggcaa tcgcttcatc tctcgttttt ccgtatgtga ttacctttgc 2343901 aatcatgctg tcatagtacg gtgggatgga atagccaggg tacgcagctg aatcgacacg 2343961 gacaccaaga ccgccaggag gcaggtacat tttaatttca ccaggtgacg gcatgaaatt 2344021 tttgcttggg ttttctgcgt tgattcggca ttcgatggcc cagccttcaa attcaacatc 2344081 ttcttgcttg aggctcagtt ccattcctga agccactttg atttgttcct tgatcaggtc 2344141 agttcccgtc accatttctg tgactgggtg ctccacctgg attctcgtgt tcatttccat 2344201 gaagtaatag cgctgttcat tgtagtcata gataaattca actgttccag cacctgtata 2344261 gccaaccgct ttggcagcct ttaccgctgc atctcccatt tgctccctga tttctgaatc 2344321 aagggcagga gatggtgatt cttccaaaag cttttgcagg cgtctttgga tcgagcagtc 2344381 gcgttcgccc aaatggatcg tatttccgta gttatcagca agcacttgga tctcaacgtg 2344441 gcgaaaatct tctatgtatt tttcgatgta tacacctgga ttcccaaatg cagttgccgc 2344501 ttcctgctgt gtaatcttaa tgccattaat cagttcctct tcagtgcggg caaccctaat 2344561 tccttttccg cctccgcctg cggtggcttt tataattaca ggatacccaa tttcattagc 2344621 aagcgaaacc gcttcttcca cattttctat aattccctgt gaacccggta cgattggcac 2344681 gccggcctgt ttcatcgttt cccgcgcaac gtcttttgtt cccatttttg aaatggcgtc 2344741 agcgctcggg ccgacaaacg tgacattcac ttcttcacat aattcagcga aatcagcatt 2344801 ttcagctaaa aatccgtatc ccggatgaat ggcgtccgtg ccagtcagct ttgcaacact 2344861 cacaatattt gtaacgttta aatagctgtc ttttgatgct ttcggtccga tacaaaaagc 2344921 ttcatcggcc atttgaacat gaagggcatc tttatcagct tctgaataaa cagcgacagt 2344981 ctcaattccg agctctctgc aggctctgat gattctgaca gcaatttctc ctctgttggc 2345041 gatcaatagc tttttaatca tgttcagtct ccttactccg cttttacaag aaatagaggt 2345101 tgtccgtatt cgaccagctg gccgttttct actaatactt caacgatttc gcctttcact 2345161 tctgcttcga tttcgttgaa aagcttcatc gcttctacaa tgcagacaac tgtgttttca 2345221 tttacttttg aaccggctgt tacatacggg ccagcttccg gtgatgaaga agcataaaat 2345281 gttcctacca ttggtgaagt gattttatgc agattctcat cttgctttgg tgcttcttgg 2345341 gcaggtgccg ctgcttgctg cgcttgcggc tgaactgcct gcggagcctg tgcttgtaca 2345401 ggtgctgccg gtgcctgctg catgacttga accgtgcctg cttcgtgttt tttcagtttt 2345461 aaggatacac cttcattttc atatacgaat tcgtcaattg tagactcgtc aattgcttta 2345521 atcagctcgt ggatttcttt gatatttaac attcaatcgc actcctatgt atgaaatttc 2345581 tttttttata ggttactact aaaagtacat actatgttca tcttacagga gcggactttt 2345641 gaattcaact ctaatatgac agcaacgcaa aaagcccgct tgtttagcgg gcttttttcc 2345701 ctcattctta tttagagggt tcaaatgtga cagcgacatc tttcattgtt ttgatttctt 2345761 ttgccacaag gtctataatg gctgtcgcct tcgatttaga gtgtttgtct gatttgactg 2345821 taatattgat tttatctcct tcagcattaa caagcgcatc ctcgtaacct tgtgttttaa 2345881 tcagcgtttc cagctgtttt tctgttcctt ccacttcact gagagccgtc attttatcgt 2345941 atgcttcgct tttctccttg gctgttgcat catcgcttga cacaatggca ttcagctctt 2346001 ctctttcttt gcttctggca tcttctaaat caagacggta cgttgtaaac aaatcatcat 2346061 cggctgtttc cgtaacaaca gttccttttt cactggcttc agcggatgtt tccttgtctg 2346121 ctgatgaatc tttcgttccc tttgttccat cttcttttcc tttttcagtt tctgtaccgc 2346181 ttttttcctt cgtgtcttgc ttggcaggcg ctttttcagt tgcgacctct ccgctgtcag 2346241 acgcgctttt ttcactttgc atctgcacgg cgtttttgct ttccggcgac atgatatagt 2346301 agacgcttaa caccacgaca agactgagca ttgttaatag ccaaacggtt tgttttttaa 2346361 gcatttatga atcctccttt atttttttag gggcaaccgc aacccggtgg cttggaacat 2346421 ccaggacccg tgtcaccgct tcgataatgg tttgttttat ttgaacgttg tccactcctt 2346481 gagcaacaac gagtacaccg cgtatatcag gttttttcgt ttggacgacg acaggtgttt 2346541 ctttatcgcc gtttttgatc atgacgattt cttcctccga tgattggtct gtaacgcttc 2346601 tttttccgcc ttctttgtca gtttcttcag tggttgtatt tttgtttgat ttgttttttt 2346661 cgtatacttt cagcgacgtt gcatctacat tcacgacaac cgagacatcg tccacaccaa 2346721 tgattgtttc aagaatttct ttcagttgat tttcgtattc tttttcatag tcatcgatcg 2346781 agtctttagg tttatcagat tttgaggctt taaacacttc ggctgttttc tctttgctgt 2346841 ctgcggaatg ttgtgatgat acggccgtta tcgttttggc gttttcagtt ttctcaggtg 2346901 aagaaaacag ctggctgaca agcataaagg aaactccgag aacaaaaacg aatagaaagt 2346961 aatgatattt ggtcagcttc ggcttttcgc cgtccttcgt ttgtcccgga agaaactgct 2347021 ttttcaatac attccataat ccgtttttat tcattgccga cactctcccc gccttccata 2347081 tgaaccgtaa ttttctcact tccgatttcc caaatgtccg cgagctgcgt ttgtatctgt 2347141 ttggcttctt tttgttcggc tgcttctttt gttacgtatg catgatctgt atcaatgtgg 2347201 accggcgcga ccgtttggac cgttttttca gaagacgggg ccatatacac gctgattgtt 2347261 ttaatatcct cttctgaatc taccttttct cctgccgtga gtttgatgcg gcctacttta 2347321 tattcatcat gactgaatct ctcctccgct ttctttttta gttggacagc catttcttct 2347381 agaatatatg cgcgctggga agcttgtatt tctatttttt ttgaattgat ttgatttttt 2347441 atgtcggcag actctgactg cccgtttttt gtgaggtatt caaagatgac ttcggggtct 2347501 gtcttgaaaa gtttaaaaat cggcgtaagc atgacgacaa tcaagagcag gctgactacc 2347561 atttttgcgt acttttgcat gctggagctc ggcagcagca tatcaatcac aattgcaaat 2347621 aggataaaca acacgatggt ggtaagccat tccgttaaaa aactcatttg cctgcctcct 2347681 tcatttcatc atcatcgtga ggtttccggc tgtgattatg acagtaaggc ttaaaaaaaa 2347741 catgagagac acaatggcga gagctgcaaa aatataaatg acgcttttgc tgatgacgtc 2347801 gaggcaggtg atgacgggcc cgcctcctag cggctgaaga atcgcggctg ccagcttata 2347861 aataaaagcg agggaaagca ctttgattgc cggaaatgcc gcaatacaga tcaaaatagc 2347921 gacaccgaga atccctaccg tatttttcag cagtaaagag gcgctgatta ctgtatctgt 2347981 tgcgtctgta aacattcggc caagcacagg aataaaattt ccggttataa atttagccgt 2348041 cctgagcgta atgccgtctg tcactgcagc tgacgctccc tgaacagaga tgacgccgag 2348101 aaagatggta agaaaaacag ccagtgctcc gatggcgata tttctgagca ggttagccag 2348161 ctgcgttact ttgtattgtt cagtcatcgt gctgacaatg ctcagaatcg ctgataaaaa 2348221 aatcagcggc atgacgatat tctgaatcaa gagaccgctc gtgttcatca ggaagaggat 2348281 aacaggatga aagaaggcag cagatacagc tccgcctgag gaagccaaaa gcgccaagag 2348341 gagcggaatg agcgccagga taaagctggt catcgtctga atcgcctcag ttgcatagtt 2348401 aattgccaca tgaaagctat taagcgcaag gataatcagc accatgtaca caattgagta 2348461 agcgacctta ctgacggtgc tttgctgaaa agcattttgc aaaagctgca gaatgacgca 2348521 aaaaatcgtg agcaaaatca atgtgcccag cagctttccg ttggcaagca cttcatgaaa 2348581 caaataagaa aagagagctt tcagccattc ttgcggtgag aatgatttat cgccattgat 2348641 aaactccatt aagctgcctt tttggctttc cggcagcagt ccgccgtatt ctgtcataat 2348701 gtcattccaa aattccccga tcttatctgt ttcaagcgag gctgctgtcc tttccgctaa 2348761 ttgctcggct gtttcagcat ggtcttccgt ttgttctgca ttaccagctg cttgtacaat 2348821 ttctgcacgg cctgctatga tcagcacggc caaaagcaaa acccattgaa agcgcttcaa 2348881 tctaccgcct cctttcggtt atgacataga aggtataagt ccgagaatcg tttcgataat 2348941 gacggttaaa ataggcacag ccattacgag tattaaaatt ttccccgcca attctatttt 2349001 cgaggcgatg gctccttgac cggcatcttt tgtgagctgt gccccgaatt cagcaatata 2349061 ggcgattccg ataatcttta aaatggtttc aacatagacc atgttgacat ttgcattaat 2349121 cgcaattttt tctatcattc gaataatgtc gtagatttgg tctaccaaat aaagaaaaat 2349181 ggcacatccg gcaaaaacga cgattaaaaa cgcaaaagtc ggcttttgtt cttttacaat 2349241 taaagaaagg aaggtggcga tcagccctaa acctacaatt tgaacaatgt caatctgcaa 2349301 gcccccctat ccttggaata aaaacacagc ttttatcttt ttaaataggt catctacaat 2349361 cgtggcgacc ataaataaaa tatagataaa acctaacagc gtcacccact gagcatattc 2349421 tttcttgccc atctgatcca atatcgtgtg taaaaaagcg accacgattc ccactccggc 2349481 gatttgaaat atgacattca cgtctactcc cattttattt ttgctcccct cacgtttaca 2349541 tcaatagaag aatgagtaac aagcccgcta aaaagcccaa actttttatc atcttttcgt 2349601 ttttcgcttg cgcctgctca gcatccgctt ctgaggcttc caaatgtgtc agcgccagct 2349661 tgatgtgctt ttgctgagag attcgatcat gaatcccaag cgtctcgcca aactgcttca 2349721 gcacttcgta ttcgcttttt ttcaaagaca gggtgtccca taccttcttt aagctttgct 2349781 cccacgccgt tttcgcggaa tcacttccct tgtccagctg atcactgaat gcggaaaaaa 2349841 gagttgaaac aggctgtgcg agctgtttgg caatctgctg tgaagcagta tgaagcggtg 2349901 tatggccgta catgatttca gcctcgaggg attgaagcgc cgcacgcagc tggcggattt 2349961 gccgcggccg ttctgtataa atcttcgcca tctcaaaacc tgtccatgtt gtcgctacca 2350021 caatgaatac agcgcccagc agcttcagca tgttttcacg cccgtcgtcc tagacagcac 2350081 atttccgtct ttgtcataaa tttggctcac tgtgcccggc ccttttgctc ttgataattc 2350141 caaatagcgg tcaaaggctc tttcttccca caaacgcttc aatgaaggcc gcttcatcag 2350201 gtcggatata ctccagccat gcgccgatac gattactgaa acaccggcat gcagcgcctc 2350261 cagaagtgca tctgtatctt ccatacgccc gatttcatcg acaatcatca cctcagggct 2350321 catggatcga atcatcatca tcagcccttc agcttttgga caggcgtcta acacgtcaat 2350381 tctctgacca aattgatgct gcggaatacc gcgaagacat ccggcaatct ctgaccgttc 2350441 atcgacgatc cctgtcttta cgggcagcat gttttttttg ccggtgcttg agagcctcgc 2350501 aaggtcccgg agaagtgttg ttttgccggt ttggggcggt ccgataatca gcgtattcag 2350561 ccagctgttt tgatataagt atggaagcag cggctccgca atccccagct tttgccgggc 2350621 aattcgtata ttaaaagatg cgatgtcacg gaggcctttc acacctccgt tttccgtaat 2350681 gactctgccc gccagtccga ctctgtggcc gcctctgatc gtgacatacc ctttcttcag 2350741 ctcttcttca agtgtataca tactatagtt gctgagccgg ctcaggatca gatgggcatc 2350801 ctcggccgtg cccgcatagg acaaataaac aggttgtcct cttcgaatca attcaacagg 2350861 gcggttgatc cgaattctga cttcttcgat ttccagccat tgttgttccg gtatttcaga 2350921 aagggcgttt ttcatggatt cagggagaac ctcagcgatt tcattcaaca gagcctcctc 2350981 ctttctaccg attggcttct ttaaaatgta tgatgtgagg cagactttat gacaagcctc 2351041 tctttattta tgaacacccg ccaaaatcaa gacaacaccc gtaaaaatca gaatcagctt 2351101 tgcatacgaa agctgcccgg caatttggta gattccgaca gtcattgtaa tgataaaaat 2351161 caacggaccg acaatagcga gaatgctgtt aaccacaacc gccttccgga catcgttggt 2351221 cacaagcatg acaattgctg ccgtcagctc aatcatagag gataaaactc gtaatcccgc 2351281 cattgttaaa acagtagaat tgatatttcc aagtaaaaat ttcatagcac tctcccaacc 2351341 tcccattttt ttatatgata tgctctagct tgctgaagta gtcttgtcat tttcgtataa 2351401 aagaaagatt ctgtttttgg gcacaaaaaa agcctgctcc catttgggaa cagacttctt 2351461 tttttctttc tatgctcttg aaacgtaaga accgtctgat gtattgacaa caagtgtgtc 2351521 gccttcattc acaaagaacg gcacgtttac aacaagcccg gtttcagttt tcgcaggttt 2351581 tgtaccgcct gacgctgtat cacctttaat accaggttca gtttcaacaa ctttcagctc 2351641 aactgtgttt ggaagttcga taccaagtgt ttcatcctgg tacatcatga tatgcacaga 2351701 catgttttct agcaggtatt ttaattcttc ttcgatttga gttgcgctca gttcaagctg 2351761 ctcataagaa gaagtatcca taaatacgtg ctgatctccg tttgcatata gatattgcat 2351821 tgttttggtt tcgatttgcg ctttcgctac tttttcacca gcgcggaatg ttttttcctg 2351881 aatcgcgcca gtgcgaaggt tgcggagttt agagcggaca aatgccgcac cttttccagg 2351941 ttttacgtgc tggaagtcaa cgacgcgcca aatgccgcca tctacttcaa ttgttaatcc 2352001 tgtacggaaa tcgttaactg aaatcatgtt taatgtcctc ctatattcca atcacaaaat 2352061 aataagttct tttggggaat gggtgattgt ccggttgccg ttttctgtaa tcacgatgtc 2352121 atcttcaatg cggacaccgc ctgtttctgg tatgtaaatg cccggctcca ctgtgaccac 2352181 catacccggt tcaaggatag ctgaagatct gacggataat cccggcgatt catgaacttc 2352241 catgccgagc ccgtgcccgg ttgaatggcc gaaatagtca ccgtagcctt ttgcagcaat 2352301 atgatccctt gtgagggcgt cagcctcttt tcctgtcatt cccggcttaa tatgtgcgac 2352361 gccaagcgcc tgagcatcaa atacaacctg atagatctcc ttcaattgat cactgggctg 2352421 acctacagcg accgtccggg taatatcaga acaatatcct ttataataag cgccaaaatc 2352481 aagcgtaaca aggtctccgc tttcaatcag tttgtcactg gccacaccgt gcggaaggct 2352541 tgaacgaagg cctgaggcga caatcatatc aaaagaagag ctgtctgctc cctggcttct 2352601 catataaaac tccagctcat tggcaacagc gatttcagaa atgccgggtt tcataaacgt 2352661 caagatatgt ctgaaggcat catctgcaat cttcgcagct tcctctaata tcttaatctc 2352721 ttcactagac ttaatcaagc gcaacttttc cacggattca gccacaggca ctaattcggc 2352781 atcactgata acggcgctgt atgaagcgta agtgccatat gtcatgctgt tctgttcaaa 2352841 gccgagacgc ttgatgccaa acgattcaac agtgtcggca gtggtctgaa tcaagctgcc 2352901 gccatgttca atgatctcaa aaccctttac ctgaaccttc gcctgctcag tataacgaaa 2352961 atccgtaata aacgctgctt tgtcacccga tataacagcc aaacccgccg aacctgtaaa 2353021 ccctgtcata tagcgtacat tagtgttgct tgtaatcagc atgccgtcaa ttcccagctg 2353081 tccaaacagg tttcttaatt tctctagctt catcttgatt ctcccccttg ctggcttaat 2353141 aagtagcgaa cagcaagctt gtagccttca gctccaagac cgacaatctg ccctttcgca 2353201 acaggagcga taaccgactg atgcctgaat tcttccctgg cgtataagtt tgataaatgc 2353261 acctctacca caggaagact gatgcttgaa acagcatccc tgatcgcata gctgtaatga 2353321 ctcagggcgc cggggttcag aacaatcccg ctgtattgct cctcagcctc atgtatcgca 2353381 tctatcaaat caccttcgtg attagactgg aagaaagtga gctggatatg taaggcttca 2353441 gcaaactgaa aaagatctgt ttcaatatcg gtcagtgtct ggcggccgaa tacttcaggc 2353501 tcacgactcc caagccggtt aacattcggt ccgttcaaaa tcaaaaaatg aggcacacaa 2353561 tctctccttt tcgcgagggt ttctcatgta aaaaatgttc acttctcgtg aacattttat 2353621 catactggaa aaggattata cactattctc tatgcattcc cagcgcacgt gcaagctttt 2353681 ccgaattcag ctcattgtat tcaaatgaaa tagaataccc gacaaacagc ccgtaaagca 2353741 aataaatgca aatggtcgta ataattgtat ctgatgtcag ttcggtcacc gtgcgcacat 2353801 ctggaaaaat cggattaaaa acaaaaaaca cgagcagcca aagcaccaag ccgtataaaa 2353861 tacccggcca cattgttttt aaacgtttca atagaagaaa ataaagaaat gctgcgccaa 2353921 ttgaaattac tccaatcaaa atgatgctga ttaccgttcc cagcccatgt tttttccact 2353981 ctccgagtac aaacggctgc aatatcatat tcgggctgat ttcggaaaaa tgaaacaaat 2354041 atgcgatata agcaacgaaa ctccaaagta cgcctccgca aaaacctgtt gccgccaccc 2354101 tgccggccat tgaaacaggc ggcttttgct tctcattcaa ttcttcattt tgttctgtat 2354161 ctttttcgct tgtcatcatg gcacctccag ttaaagtgtg cccaaaaaat gaaatgtcaa 2354221 taaaaaagct cacacttttt ggcagctgcg agtaaaattt gaaaataacg ggtataatgc 2354281 atgtagaaaa agcaaggcta tggcaatttt ttcagcctgt caatctagag gtttagcgct 2354341 gtttcctgta caatagagtg aaaggaaatg gttagcaatc ctaaagaaat aggcaggttg 2354401 ataatatgtc aaaacataaa gttccgcccg cttacggcgg gcaggctgtt gtggaaggcg 2354461 ttatgtttgg cggaaagcat cattacgtta cagccatcag aagaacggat ggaagcattg 2354521 acttttttaa gcttccacgc aaacacaacc cgaaactgaa catcgtgaaa aagataccgt 2354581 ttttacgggg gatcgcggcc attatcgaag cgagtgcaaa cggcacaaag catttgaatt 2354641 tttcaagcga acgttacggg ctcgatccat ctgaagacga gacacttgag caggaagaaa 2354701 aaaaatcctc tgggctgtct atgtatctca gcctcgcagt tataggcgtc ctatcatttt 2354761 tgttcagtaa attcgtattt acattggttc cagttttctt agcggaactg acaaggccga 2354821 ttttttcctt gaacacagcg caaatcgcga ttgaaagcct gtttaagttg attttgctgc 2354881 tcggttacat ctattttttg tccatgacac cgcttattaa aagagtgttt caatatcatg 2354941 gagccgaaca taaagtcata aactgttatg aacagaattt gccaattact gtggagaatg 2355001 tccaaaacca atctcggctt cattaccgct gcggatcaag ctttatttta tttacgatta 2355061 ttgtcggcat gtttgtttat ttactcgttc cgacagatcc gctttggctg cgtgttatag 2355121 atcgtgtcgc actgataccg gtcgtgcttg gtatatcctt tgaagttctg cagctgacaa 2355181 acaaagtgcg tgacattccc ggtctgaaat tacttgggta cccgggactt tggcttcagc 2355241 tgttaaccac aaaggaacct aaggatgaac aggttgaagt tgccatcgaa agctttaacg 2355301 aacttctcag actcgaagca ttgtctgagc aaaatcagaa gccttctcac aacgtcatct 2355361 aaaatccgtt gccctgctat tactttcgga ggtggacagt tatgaatcat cgtgtacaac 2355421 ctattattgc tgtattaatt gcgctgggag cgttcggttt cctctatgtg ctggtaacca 2355481 atcccggaga aatggcaaaa atggcggtaa ccgtcatcgt ggcaggtatc attatttatt 2355541 ttattgtgaa atatgtaatg aatcgaaatg cgggcagcga aggagcagcc ttcaaaaaag 2355601 cggcgaaaca atcacggcgc cggatgaaag aacaaaaagc aaaacaccgc gccggacata 2355661 agggacgtgt cagccacctg cgaagcgttc cgagcgccag caagcctaag ccgatgattc 2355721 tcaagaaaaa aagccagact cagctgactg ttatagaagg gaaaaaaaat aaaaagaaaa 2355781 acagagcgct tttttaatag gtccactgct ttaaaaacag ctctgtccgt cttttaccta 2355841 gctcaatcag ggctagtttt ttttgttgtg ttaaatgaaa atcagtggcc attacgtcat 2355901 caacagggag aaaaatgata ttttgttcat agcgtgacgc aatgtgcctt gcgtcatgag 2355961 catccttcat cgtttcaaac agggcgccga acagttcaaa agcgttgcgg atattttttt 2356021 tcggacgctc tctttcacgc ggcgcaagcg tgacaccgat cacagggcgc tttctttcct 2356081 ttgaaaacag ccagattgga aaattgctta acacgcctcc gtcgacaacc gtggcggtgc 2356141 ctgtgtccgt ttttaatttt atcggttcaa agaaatacgg aatgctgcag ctcattctga 2356201 ccgctctggc aaccgggaac atatctggat ttaacccgta acgggccaaa tcgtccggca 2356261 aaacaatcat ggtgccgttt gtcagatcag aagcaataag gcgcagagac cctttctgca 2356321 aatcgccgaa aacccttatg cctttcgctc ttaacagatc agcaatccat ttttctatcg 2356381 tatcgccttt gtataagcca agacgccagt agatggacac ccactggagc atctttaagg 2356441 ggagaaatga gtacctctga tccagcaatt tctctccgtc cacttcttca attaaagcgt 2356501 ggatttcctt actggtgtaa cctgacgcaa tgaaagcggc aataatggcg ccggcgcttg 2356561 tacccgcaac tcttttaaag cggaagcctt tttcctcaag cacttcataa gcgcctgcga 2356621 gcgcaatgcc ttttactcct ccgccggaaa acacaccgtc aatatacatc tcattccctc 2356681 cccctccatc cgatcgttta ttaccatttt aagaaaacac gcgaagaaat agaccaacga 2356741 atgacgggtg gcgtcagcgt atcaaaaaag acggcctcct tcgagaccgc ctttttactg 2356801 attatgatgt tctgttttct tttggattga tttcagatct tttttacggg catcatcttc 2356861 ttcaaaatat tgaacaagat ccccgatgcg atcaatactg ttccagctta aatgatgttc 2356921 gattccttcg acatcgttat atattttctc ttcatcaaca ccaatgattc ttaaaaactg 2356981 ctcaagcaat tcatgtctgt ataccagccg tttgcctatt tttttccctt tagacgttaa 2357041 cacgagaccg cgatattttt cataaattaa atattcgtct ttatctagtt tttgaaccat 2357101 ttttgttaca gaggagggat ggactgccaa tgcttccgcg atatcggaaa ctcgtgcata 2357161 tcctttttct tcaatcagca tataaatctg ttcaatataa tcttccatac ttggtgttgt 2357221 catcgaaacc ctcccaaaaa gcaccttaac tttataaacc attacaagtt tacactaatg 2357281 aacttgaaaa aacaaggatg ctccgcgggt caaaagccct gtttaccgct tataattcca 2357341 ttcatctgaa gcgtactttg tttcagccaa gtgatgaaca aaatcaagct cttcctgaga 2357401 aagttcatat ggctccaaat gaatgttaag acctgtttca aatccttctt taaaggcttt 2357461 acgagcctca tccatcgtca cccgcttttc gatgagttca ttaatggcaa ccgctttatt 2357521 tttgaaattg cgctgcatcc gctctcttac tctttcactt ggatataaga acagatcgaa 2357581 cagcttgtcc tcatctaaat caagaagaat ggagccatgc tgaagaatca cacctttttg 2357641 tctcgtttgc gcgcttcccg ccaccttgcg cccctcaacc actagttcat accacgaagg 2357701 cgcgtcaaaa caaacagatg accgcggatt ttttaagctt tctttttctt tttcagttct 2357761 cgggatggca aagtaagcgt ccagaccgag atttctaaag ccttgaagta tgccttctga 2357821 aataacccgg taagcctcag taacagtcgc cggcatctcg gggtgctctt ccgaaacaat 2357881 tacgctgtat gtcagttcct gatcgtgcag cacacctctc ccgccggtcg ggcgtctgac 2357941 gaatccgaga ttatatttat gtactgcttc aaaattgatt tcctttttaa tattttgaaa 2358001 ataccctaca gaaagtgtcg ccggattcca gccgtaaaaa cggataaccg gggggatttt 2358061 cttttcgctg tgccaatata aaagcgcttc atcaagcgcc atattgaatg caggacttgc 2358121 attgcctgag tctataaacc gccaagtttc tttttgcatt ttaagacctt ccttaccgtt 2358181 ttaatagaat cagtttatca aactgtcggg aaaatgaaaa atattttagt tccattatag 2358241 atgacaatca cgctgtgctt tactataata gtatttgtcg aaaacggctc tatgaccttg 2358301 ttttatgaag cagggttttg attttatatg ctaaaggagt agaatcacat tgtctaatat 2358361 gatcgttttg attatttttg ctgcatttat catctatatg attgcttcat atgtctatca 2358421 gcagcgaatt atgaaaacac ttaccgaaga agaattccgc gcgggttacc gcaaagcgca 2358481 gcttattgat gttcgtgagc caaatgagtt tgagggcgga catattttag gcgcccgcaa 2358541 catcccgctt tcccagctga aacagagaaa aaatgagatc cgtacggaca agcctgttta 2358601 cctgtactgc caaaacagtg tccgcagcgg acgcgcggca caaaccctgc gcaaaaacgg 2358661 ctgcactgag atttacaacc taaaaggcgg ctttaaaaaa tggggcggaa agattaaagc 2358721 gaagaaataa agcaaacagc tgtctggtag acagctgttt ttatttatct ttcttccgcc 2358781 tcgtatctga gcactgggtg tctcgccgct tttgtttcat ccattctttt tacaatcgtt 2358841 gtatgcgggg cctcctgaac aagctccgga ttctcctccg cttcttttgc gatttgaatc 2358901 atagcatcaa taaacgcgtc cagtgtttcc tttgattcgg tctctgtcgg ctcgatcatg 2358961 atgcattctt caacattaag cgggaaataa atcgtcggcg gatgatagcc gaaatcaagg 2359021 agccgttttg caatatcaag cgtacgcact cccagctttt tctgccgctt ccctgataat 2359081 acaaattcat gcttgcaatg gcggtcaaac ggaagatcgt aataaggcgc gagttttctc 2359141 atcatataat tggcgtttaa cactgcgttc tcagtaacag cctttaatcc gtcaggcccc 2359201 atggagcgaa tatacgtata cgctctcaca ttaatgccaa agttgccgta atacggcttc 2359261 acacggccga tcgcatgagg gcggtcataa tcaaacgtaa agcgcccttc ttttttgact 2359321 aaaactggct ttggcaaata aggaatcaga tcttgtttta cgccgacagg gcctgagccg 2359381 gggcctccgc cgccatgagg gcctgtgaat gttttatgca ggttgaggtg caccacgtca 2359441 aatcccatat caccaggtct cgccttgctt aaaacggcat ttaaattagc gccgtcataa 2359501 tacagtttcc cccccgcttg gtgtacaatt tccgccatct ctgtaatctg ctcctcaaac 2359561 aagccgagcg tgttcggatt cgtcagcata agagctgcag tttcttcatt cactgctctt 2359621 tttaaatcct ctaaatcaac aagccctttt tcattcgatt tcaccgtaac ggtttcaaag 2359681 cctgctactg ttgctgatgc aggattcgtc ccatgcgcgg aatcagggac aatgaccttc 2359741 gtccgcttga aatccccgcg agcttcatga taggcacgga tcatcatcag ccccgtccat 2359801 tcgccgtgcg ctccggcagc aggctgaagc gtaacctcat ccattcccgt tatttcttca 2359861 aggtgtttgc ttaaatcata taaaagctct aatgcgcctt gcaccgtgtc ttcatcctga 2359921 agaggatgaa tcgcagcaaa accaggaata cgtgcgattt tttcattgat tttcggatta 2359981 tatttcatcg tgcaagaacc gagaggataa aaaccggaat ccaccccgtg attgcgtttg 2360041 gacagcgctg tataatggcg catgatgtcc agctctgaaa cctccggcag cgctgcgtct 2360101 tcgtcacgaa tataggtgtc tgacaagagg tcccccaatt cgatttccgg tacatcgagc 2360161 tccggcagac tatagccgat tcggccttct cttgaaagtt caaaaataag tgcctggtcc 2360221 tgattactca tggcgatccc ccaattcctg aatgagtgcg tcaatttctt cttttgttct 2360281 cagctctgtt acagcaatca gcatatggca gtccagctct ggatacgtca acccaagatc 2360341 atatccgcca atcatgcctt ttgccagcaa acgcttgttc acagctctca ccggctcatc 2360401 cagtttgatg acaaattcat taaacatcgg cccgtcaaac ataacagtaa ggcctgcttt 2360461 ttttgcttct tgctttgcat agttggcttt taagagattt tggcgggcta tatcttttac 2360521 gccgtttttt ccgagagcag tcatggccac tgatgctgcc agcgcattta aagcttggtt 2360581 cgagcatata tttgatgttg ctttatcccg gcggatatgc tgctccctgg cttgcagggt 2360641 aagcacaaag cctctttttc cgttttcgtc ttccgtttgt ccgacgagac ggcccggcac 2360701 ctttctcatt aattttttag taacggcaaa aaagccgcaa tgcgggccgc cgtatgctga 2360761 aggaatgccg aaaggctgcg catcaccgac gacgatatca gactgaaact tgcccggcgg 2360821 agtgagaaga cctagcgcca gcgggttggc tgaaacaata aacatggatt tcccttgatg 2360881 agcgataggc tcaatatcct ttagcggctc gatcctgccg aaaaaattcg ggtactgaac 2360941 gatcactgcg gctgtgttct cgcaaacggt ttggcgcaat gcatcaagat ccgtaacgcc 2361001 atccgcagcg ggtacttcaa caacatcaat atactgacct tttgcgtaag ttttcagcac 2361061 ctctcgcgat tcaggatgca cggtttttga cacaacaatt tttttctttt tcgtgtggcc 2361121 tgaagcaagc attgctgctt ctgccaaggc tgttccgccg tcatacatcg aggagttggc 2361181 gatatccatg cctgtcagtt cacagatcat cgtttggaat tcaaaaatag cctggagctc 2361241 tccttgtgaa atctctggct gataaggcgt atatgcggta taaaactcag agcgcgaaat 2361301 gacatgatcc acaatgacag gctgatagtg gtcatataca cccgctccta agaaagaagc 2361361 gtattgtacg gtatcacgat ttttagaggc cagctttgtc agttctcttg ttaattctgt 2361421 ctctgatttc gcttttttga tttgatgctc ttttttatat ttgacgtttt ccggtatatc 2361481 agcaaataaa tcatcgatgc tgcttacgcc gatagtagca agcatctcct gtttatcctt 2361541 ttctgttgcg ggcaaataac ggtgcttcat gtgttgtctc ctctctccaa gaaaaaatat 2361601 tagcgtttat aaaatggtgt tttgacaacc tttgctttca ctaatttttt gcgtatctct 2361661 acatctacaa cagtcccgat ctcactcgtt tccgaatcaa ttaaggcaag gccgacgttt 2361721 tttcctaatg tcggtgactg cgtgccggtt gtcacctttc cgacagactt gccattttgg 2361781 aaaacctcat atccgtgccg cggtatccct ttttcaatca tttcgagacc gacaagtttg 2361841 cgcttcgctc cgttttcttt ttgttcactc aatactgact taccgaaaaa gtcagactcc 2361901 tttttgtgct ttacagcaaa gcctatacct gcttcaatcg gtgtaatatc ccgggtcagc 2361961 tcctgaccgt agagcgggag cttcgcttca aaccggagtg tatcacgtgc accgagaccg 2362021 catggaatca atccgtatgc atcccctgca tcgatgattt ttttccaaat atgcatagca 2362081 tcatcactgc ggcagtaaat ttcatacccg tcttctcccg tatagccagt gcgtgaaata 2362141 agtgctttgc ggccgctgat atcggcttca tcaataaacg caaacggctt taatgcagac 2362201 acatccgcat ctgtcagatt ttttaagatc gcttctgctt tcggtccctg tacagccaag 2362261 agcgcgattt gatctgactg attgtcaatc tgcacatcac ctgctgcatg ttctttcatc 2362321 caagccaagt ctttatctat attagaagca ttaatgacaa gcagatagcg gttctctcct 2362381 ttttgataga taagcaaatc atcgacggtt ccgccatccg ggtaacacat cgctgtatat 2362441 tgagcacggc ctggcgttaa cgcggaaaca tcatttgtca tcaatctttg caaaaaagac 2362501 agactgtcgt tccctgacac ttcgacttct cccatatgag atacatcaaa caaaccggct 2362561 gcagttcgga cagcctcgtg ttcttttttt atagaagaaa attgaacagg aagctcccag 2362621 cctccgaaat caatcgtttt tcctccatat tccttataca ggtcaaataa cggcgttctt 2362681 ttcagcatct aattcctccc ctttatcaac ggcgcagcta aaaaacatac aaaaaaggac 2362741 agagaaacac ctcatgtaaa atgaaggttc tctgtcctgg cacctgaaag tttactttgc 2362801 atacgcaaag acgtcccctt tggtggtttg cgcatccgca caaacactct ccagagttgc 2362861 gtcgagcaag agttcttttg cctgagagat tcactccgca gtttgctcct tcggcgcctg 2362921 tatcccgagg ttttcggtca ggtctctccc cttgctgtca ttcgctcata ttttcatgct 2362981 gttatggaca tactatagca atatcttaca tcaaatacat actcatatcc taccatcatc 2363041 actatatgct gggcaacagc aatttgggca gatttttctt atattattca tcttaagaat 2363101 cgaagaataa gaaaggcggt ttcaaagcaa tgaatacaga aatgatctac gatgcaaaat 2363161 ggcctgaaga atttgctgaa agactgaaaa acgatggccc ttgggcaaac tgggaactgt 2363221 acaagctctc tgcagaaatc cagaaaacat tagcaattcc agagtttgaa ggcttacggg 2363281 ctcctttata tctgccttcc tttacgccgc tcccccacca gcttgaagtg gcgcaaaaag 2363341 tggttgaaaa aatgaacggg aaagcgattt tagcagatga ggttggtctc ggaaaaacgg 2363401 ttgaagctgg actgattcta aaagaatata tgattcgcgg gttagcaaaa aaaattttga 2363461 tccttgtgcc cgcttccctt gtgtcacagt gggtcaaaga gcttcaggaa aaatttttga 2363521 ttccggctgt tgaacaaaag aaaagctatg tgtgggagca atgcgatatt gtcgtctcat 2363581 caatagacac cgcgaagcgc tcgccccatc gagaaatcgt tctgtctatc ccatatgatc 2363641 ttgtcattat tgatgaggca cacaaactga aaaatagcaa aacgaagaac tatgaatttg 2363701 tccggaatct cgtaaaaaaa tattgcctgc ttcttaccgc gacgccaatc cagaaccgta 2363761 tcgaagagat tttcaatttg gtgtccttat taaaacccgg ccatttaggc agtcagaatc 2363821 actttcagga ggagttcgcc aagaagaaat ccagtttaga agcgcatgaa catttaaaag 2363881 atcttgtgaa taaagtcatg atccgtaaca ggcggcatga tacagggctg aattggaaac 2363941 agcgccatgt tgaaacagtg ccgattcaat tttctccatc agagcaggcg ctttatgatg 2364001 aaatttctcg tttgaaggac agtatcaata aaccagccag catgttctcg attatgacct 2364061 tgcaaagaga atgctgttcg agcagagaag cggtatatat gacgctgaaa aagatgcttg 2364121 atcaaaaaga gaaacaagca cctgccattg atgaggatac gatttcagtt ttgatagatc 2364181 gcatcaatca agtgacacaa aactctaaag cgcttcaagt tgttgacttg atcaaaaaga 2364241 tcgacgataa ggtcatcatt tttacagaat accgcgcaac ccagatttat ctgcagtggt 2364301 ttcttcagca aaacggcatc agttctgtgc cgtttagagg cggatttaaa cgtggaaaaa 2364361 aagactggat gaaggatctt ttccgcggaa aaatccaagt ccttattgca actgaagcag 2364421 gcggtgaggg aattaacctg caattttgca atcacatgat caactatgac ctgccatgga 2364481 acccgatgcg gcttgagcaa agaatcggaa gaattcacag actcgggcag gagcgtgacg 2364541 tgcatattta taacatggcg acaaaacata cggtggaaga gcatattcta aagcttttat 2364601 atgaaaaaat tcatttgttt gaaaaagtgg tcggtgaact tgatgatatt ttaacgaaaa 2364661 ttcaagtgaa caattttgaa gagcaccttc atgacatttt gtatcactca gcaacagaag 2364721 aagaaatgaa aataaaaatg gataacttaa cctcattttt gtcttataaa aaacagctgc 2364781 ctgctgaaaa aagaggatct tagcctgtaa ggaggtttta ttagtgagac agcaagaggt 2364841 tcacgatttt ctgctgcgtt tttttcaagc aaacagctgc caaatcgtcg atcaaggctt 2364901 aggctatatg acagtgcagc ttacagttga aatggacaaa caaatcatga accgcccttt 2364961 ctactggcat tggcgcgaga agacaggcgg tgatccgaat ccaatgaaaa tcacttttat 2365021 tacagataaa gaaaatgcgc caaaagacct agatggtgaa tttatatatt ttggggcccc 2365081 gcgtcttttt caaatattca aagctgttaa acaaaatggg agatttacca gaatgtatga 2365141 gaaaattgaa tcagccggag ctaaagtccc acttcagcct tggcttggta taaatgtcac 2365201 gatttcatac cagtccgaca tgaaaaagga taagttattg tcactaggtc ttcacctagt 2365261 ctctggaacg ataattgaag attttcaaag caagctgacc cagttttcac tgacgtctca 2365321 aatatgtgac tattgcttca ccatttcacc tatgatcaaa ccagaaagcg gacttaagcg 2365381 tatggaaaac tatatttcca aatccgctat gcaggagccg tccgactggg cggaacaggc 2365441 ggttaacagg tggaagaatg atatgacatt gcttgataag ttttacgagc atatagaaga 2365501 aaaaccagaa gaataccatc tagaaaaaca ggcgctgaaa accttgtatc aaccaaagat 2365561 atcagttgaa attgaaaatg gcggattgtt ttatctgcaa aataatattt caagctaact 2365621 tttttaccat tcgacatcat tctcgttttt tttgagaaaa tacgattata ataaaggtat 2365681 attggaaaaa aattctggtg atttaatggc aaatgacttc cagagactaa tgaagcatac 2365741 aataagtcat ggccggactg gctgaaatac ataaacaagt attttaggag gagaaactgc 2365801 atgaagaatg caaaacaaga gcactttgaa ttggatcaag aatgggttga attaatggtg 2365861 gaagccaaag aggcaaatat cagcccggaa gaaatacgaa aatatttact tttaaacaaa 2365921 aagtctgctc atcctggtcc ggcagccaga agtcataccg taaatccttt ctgaatgtgc 2365981 tataatatca caaggaaggt gatgacattg attggccagc gtattaaaca ataccgtaaa 2366041 gaaaaaggct actcactatc agaactagct gaaaaagctg gggtagcgaa gtcttattta 2366101 agctcaatag aacgaaatct acaaacgaac ccctccattc aatttctcga aaaagtctcc 2366161 gctgttctgg acgtctcggt tcatactttg ctcgatgaga aacatgaaac cgaatacgat 2366221 ggtcaattag atagtgaatg ggagaaattg gttcgcgatg cgatgacatc cggggtatcg 2366281 aaaaaacaat ttcgtgaatt tttagattat caaaaatgga gaaaatccca aaaagaggag 2366341 tagtgcctga gcagaggcac taactcctct tttgtcaata accatcgaga cggcccagta 2366401 tatgaatact gggccgtctc ttttttttgc tgttattaat ttttatcctc gctatgcgct 2366461 ttttcatttt ctttcacgta accatcttta tcagtatggt cctttttgat tgtcaagccg 2366521 ttccactgtg tagcttcgaa tgagaattga agcttaatgg agttgccttg atatttattt 2366581 tgaaccataa gccctttttc atcttttgtt ttatcatcct tgaattggat ttccatttga 2366641 acctgatcga agtcagttgg tgtttttgga acaccatcat attcaggagc ggttttacca 2366701 tcaattgttg ctacattgac tttaccgctt gcatttaaga atttagggtc aatttgtttt 2366761 ttgatttttt cagcagccgc tgcatcattt ttagcagaca tcaaatacaa gtctttaagg 2366821 ttcgcatcat ctaaaataat gtttttcggg tagccattgc cgccctcttt tccaactgtc 2366881 aacaatgtca cttcaaactg gctgaggaaa tcttctggag atgtattgct gccgccgttt 2366941 gctttaaaat ctccataatt aagcgccatt agaacttctt tgatcgcaag tgatccgtta 2367001 ttttcaaatt ggaaatcctt tgtcaactta tctcccggct ttagatttga taagttcaca 2367061 ctcgctgaat tctctttagc agataaatca agcgtacctg atgcaaaagt agcatccttt 2367121 gatttaatgt cgttaaatgc tgcccatgtt cctcctccaa ctaaagctaa tcctagtgct 2367181 gcagaagcaa ctcctaaact caatttcttt ttcataccca tggtaagctc cccttttatt 2367241 gaatgatttt atatcgaaac ctgttgccag gtttacaact gaagttaagt agacatggtg 2367301 ctgtcctttg tatctgtttc caaggctttt gtctttcttt caatttctct aatggcgctg 2367361 ctgatcgtca caaaagcgta aactaacagc atcacgccgg gaacaatcaa taatacagcc 2367421 gttccaatcg gctggctggc aaaatgaagc atatagccgg catatggaag ctgaaaacct 2367481 gtgtattgcg cgcgaacatt ttcgtccgat acaggcgctg aatcagctgc tgcattatta 2367541 tcaccttttg ttttaaataa caaatggtct ccttgctttg ttatgtcaac aattctgtgg 2367601 gtgaccgccg tatttgcatc ctgcataaat gtaataacgt cacctttttg gagctctttc 2367661 acatcagtga tttctttgac caatattaag gaacctgtat tgaactccgg ctccatcgaa 2367721 cctgacagaa ctgatttcag cgtataccca aacactgccg gctctccccc ggatgaacgt 2367781 gttgaaatca cgacaagtgt cagcacaata ataagagtaa agatgatcac gtataaaata 2367841 ttactgatca gcttcattgc ttttttcatc ctcttccccg ctttccttct ggtctgattg 2367901 agtttctttt tctttggtta cagcttcttg agatgtttct tctttcattg ttttttccgg 2367961 tatatctttt tgtgttgttt cattctcctt tttgacgtcc gactttgttt cttttttagg 2368021 gactgtcggt ttttcatcgc attttgcaag cctcataggc tccgaccact caaatgtact 2368081 gccgtttgcc gggtagcctg ccggtttata tactttaaat gcataaatgc cgggtttcat 2368141 ttttttcttg gtctcaattt tataaagtga atcgccgatt tgattggaga caaatccttt 2368201 ttcgatcacg ttcccatcct ttaacggttt gcgggcattt tcaagcttat gaagctccca 2368261 cttccacttt gatttcttaa gtttctcacc tgtattttcg agcacagcaa ataaggcgaa 2368321 aggtgagcat acagtgcctt tcgtatccgt ttgatctgat atgtgcaaat cactttgatc 2368381 ccagcgttta tcataatggc agtttttatc tgtatgctga aagtctttac acgtttgaag 2368441 tgagacatca aatgtttcaa tatcatgaaa agcagcgctt gtatcatcgg aaaattgtaa 2368501 gcatattgcg gcagtcagac tgaaaatgac tgaaagctga aagataagca gaactttcag 2368561 tttcgtcttc gccttttgct gattgtgaaa caatcgaaac atatcttacc tcctgtaaaa 2368621 cactgtaact tgatatgaca atcgttctct ttaaagaact tcacaaatag agtataatca 2368681 acgatttata gatttaaaaa caccgaaatc gctcattttg ttcgtttaaa agaatgtttt 2368741 catcatatta caaagtcttg ctcagtattg ctcatttttt caatttttta gaaatttttg 2368801 ggattgttat gtgagaattt aaatgcatat cccattatta tttggtaata ataaacaaag 2368861 aaagggtgac agcatgatga tcaaacaatg tgtgatttgt ctatctcttc tcgtctttgg 2368921 caccacagcc gctcacgcag aagaaacacc gcttgtaacc gcccgccaca tgtccaaatg 2368981 ggaagagatt gctgtaaaag aagcaaaaaa aaggtacccg ctcgcacagg tactgttcaa 2369041 acaaaaagta tgggaccgta aaagaaaaga tgaagcagtg aagcaatacc atttaactct 2369101 gagggaaggg tcaaaagaat tcggcgtttt tgtgacgatt tcatttgatc cttatagcca 2369161 aaaggtcaat aaaattgcca tattagaaga atatcaataa ggtcctccat tttttgaagg 2369221 accttattcg tttatttgcg gttatttttt ccgtttcagc caaagtcgga agccataggg 2369281 taaaataccg aaccactgct gggaaacagg cgtttttgtt tctttccgca cctcttttcg 2369341 ttcttttcgc tcatctctcg gagtatctat atatttgaca aattgctgcg tcatatattt 2369401 aacataatca ttcgttttca cgtgatcacc tcatcattca attattatga gtgttgtctc 2369461 acatgacttt ttttataccc tttacactgt tttattctgt ccatctcagc agttttttct 2369521 gtttttggtc aaacacgatc tgtgcagttc tttctgttcc cgaatccgtt gacactctta 2369581 agttgatttc tttttgttct tttatcgatg tatcatgaat gtaataagaa acccgtccat 2369641 atagaaattg ctgcgtaccc tcctggcctt tccgttcctc tagaacatgc cgaatcgaaa 2369701 gaagcacccc attttgaagc aaattctctc ctatgtataa ctcttttgtt tccttctcaa 2369761 acatgcagcg tgaaatatat tgagcagcaa caaagttcac gattaacagc acaagcgctg 2369821 acacaaaaag aacagctgga taaataaacc ctcttgtacg atacattcac ccccctccta 2369881 aatacgaata gactggaaaa gcagtttgat acactttttg gtcttcactc tcaattttca 2369941 gcaaaacaac accattttca atatcagctt tcatggcagt aatatgatct aaaatcggaa 2370001 catgcccttt gccatccact ctttttctta tcattgaatg ataaatgtca aaacggatgt 2370061 cttgtccgga aagattggtg cagattaaca cgctcccatg ctcggctgtc ttaactgcct 2370121 gtgattcctt gcattcattc atcatctgtt ctatcgaaat catccattcc tgctgtgtga 2370181 aaccgtcatg ttcctgctgt cgagacaaaa acagatggat aatcgcagct aacgatcctg 2370241 atatgagcaa aaagactgag agcgaaaata atacgttaag aagcgtgtag ccattctgtc 2370301 tgcaaaatgc tgaggcaaaa tgatttttct ttataagctg cggctttgat acatacgttt 2370361 tgatattcgc cctcctcctc ccacttcatt gcatagatat gattgttctt tgtaatcgtt 2370421 tttgacgcgg ctccttcacc actcatgaca tatttgctaa tgctctcatt catcatctga 2370481 tagccaattt ctcgtgattc cgccattttt tcatcagcca tcagcttgtc ccacaagggg 2370541 acgactgtca gcagcacaaa cagccacagg cttagcgcag acattgtttc tattgtagaa 2370601 aaacctttat tttctctcca cattgactct cccgctccct agataaactg ttatgtcata 2370661 aacggcatgg ccttttactc gtatttttcc gcctgcattc gggtgccctt tctcattaaa 2370721 ttccaaacgg tcttttaatg tcagcagttc tatagaaagt cccgttgcat acggacgttc 2370781 aataaccgta tcaccaatga ctaattgata ttctttttta tgaaagagaa tttttgttct 2370841 ttgttgacgg gaaatagcag tctgctgtgt gagcataata tcatttttca gctgacttgc 2370901 tgcctgtcgg acagctgtat tgtcataagc aggaggaagt gtagtgaaga cggccaccag 2370961 gaggatagag gcaaggctta acacaagcaa actttctaaa agggtaaacc ccttctcctc 2371021 gtttaattta atgttcaacc ttaacttctc cgccggtgat gataatgcgc ttaccatttg 2371081 gacagacagc atcctttttc acatagccct ctgactgtaa atcggcaagg ctcggagttt 2371141 gtccttcatg atcaagctca aatgcagtca tttgtgcctt aaccatgttt tgtaagcctt 2371201 cacagccctt tttttgaatg gtttgattat gtttcgtgac gttcggtatc gtaattaaaa 2371261 gcaaaatcga aataataaag agcacgatta acatttcaac aagtgtaaat cctttctcat 2371321 tcatcagcct cttcctttca catttgattc atcatctgat acataggcac aagcatagat 2371381 aaatacacaa gtaagatcat cgctgcaaca aatccataaa tcattggctg aaggatgcct 2371441 gtccattttt gcgctttgtg ttccagccgc tgtaatatga attggctgta tgtgaaaagc 2371501 tcccgatcca atcggccgct cagctggccg tgagatatga cttttgataa atcagtttca 2371561 taaaaaaggc ttccacaaat agcggattca attgactcac cggcttttag ccgttcaatc 2371621 aattgttcag cctcgcagcg gtagaaaggg agaaacgttt gatgtttaaa tgcattaagg 2371681 ctgtcataaa ttgagaggcc tgattttaaa aggctgctta gctgcaaaga aaaaaagtag 2371741 ctgttaaaca gctttacaag ctttccaacc aaaggaatcc tgatacaaat cagcatttgc 2371801 cgggcaggtg attttttctt aaacacaagc caataataaa tcccgatacc tgctgtaaaa 2371861 agaacaagca aaatgatcac aagatcaata tgctgaaaaa aagcaaaaag catatcggtt 2371921 gaacgtgagg tttccatatt catcgattga tagataccgg aaaactgagg aatgatgatg 2371981 gactgtaaca tataaaacat gacagcgacc gtaaagatga ggaaaagcgg atagcgcagc 2372041 actcttttca gctggtctgc ctgtgcaatt tttcgttcca gcagctctcc gctctggatc 2372101 attgaagcag gcagttcacc atgtgtttca gcaaaataac aaatacctac ggcttcctta 2372161 tgaaatgaca aactctttag tacttgataa aacggagccc cttccctcaa acaagtgacc 2372221 gaatcagtca agtcagccgc ctgcctctta ttcatctgaa gttccatcag gcgtaatcca 2372281 tccagaagtg tatatccgcc cgcagtcatt tcaccgagcc tctttaataa cctggcttga 2372341 tcctttaaca accagacttt tctaatcttt ttcatgataa acccaccggt catagttgtt 2372401 tgtcgttaaa tagccgagcg caattccttt tctgataatt tgacgaagcg tttgatattg 2372461 gtaatttgca tgatttcctt ttgcctcctg gatacattgc tgaagatttt tcccgtatag 2372521 aagctcataa acgctagctc tcctagtatt tcgtgactgt cggcaataca ctgatgaaca 2372581 tccgttttca caaaacgggc aagccaaatc aaccaagcgc tgagccgcta ttgcaatgac 2372641 agtctgttcg atttcattca tattgatacc gaattcaagc agtctgtaaa ttgcgccctt 2372701 tgcgtctctc gtatgaaggc tcgttagtac cagatgtccc gtcatcgctg cccgcaccgc 2372761 aatttcagct gtttccgcgt ctctgatctc acctaaaata atcatatcgg ggtcatggcg 2372821 caaaattgct ttcagacctg cggaataagt tacaccggct ttttcattca cctgaacctg 2372881 aagaacatct tcgtcccttg tttcaacagg gtcctctaat gtgacaatat ttcgattaaa 2372941 gtgttttttt gcatattgaa cgagagagta taatgtggta gtcttccctg aaccagtcgg 2373001 cccggtaaaa atgagcatgc catgggaatg ttttaaaaac gagagtaatg tggctcctgt 2373061 cttcggaaat agcgacaatt tatcaatcga agggatattg tattggggca tcactctgat 2373121 cacgaggctt tcttcattaa ttgtgggcag cgttgacatt cttaaatgaa catttccctc 2373181 tttcaacttt aacgtaagcg aaccgttttg cggctttcgc ctttcaccta tatccattgc 2373241 tgaaagaaat ttaaaatgtg aaatcagtct tacgcactct tcttttttca tgtccctttt 2373301 tttcagcaag gcatgatcga cccgaaaatg aatgatagcg tcccgctccc tcggcacaat 2373361 gtgaatatca gaagcctttg ttagatatgc ctcttcaatc aagtttttgc ttaccttttc 2373421 tattgaatcc aatttgattc cctctccttt caacgcatat tgtagaaaaa gaagaaaagg 2373481 taatcaaaca gggaaaacgt gattttgtga gatgttatat gctgaaaaac caattctttc 2373541 tggcaagaaa aaagactttc aactgaatgt acccctgtca ttataatttt ccctataaat 2373601 aaaaaagcag acatggtcac catgcctgct agattccatt ttcattatgc tgttttcgct 2373661 tattgaccag tatctttctc aacggaaaga tcgcctaatg caacaatacc ggtcatttgg 2373721 tcattttcaa gaatcgataa actgcggatt taatgctctg tcataagccc cttgacatcg 2373781 tatccggtca ccctgatatg tctggtgaaa aagcggggca cgctgcacaa aatatgaaac 2373841 atcctataga gtccgccttt ttcgaggttt ctttttcttc ttccgctcct gcagcatatc 2373901 tcccgtccag cctttttttc tcaaatagag atagatcaga actgtagatg tgacaatcaa 2373961 taagagggaa aagagatatc cgtatttcca attcagttcc ggcatcactg aaaagttcat 2374021 cccccataag gcacccagag ctgtaatcgg agtaaaaagc gtcgtgaaaa tggtcagcgc 2374081 ttttacaatt tcattccccc tatgtgaggt aatgacttcc tctgaatgca gcagattgtt 2374141 aagctcccct tcaaattcgc tgatgtatgt aaatcccctg tcaatcttca gttgtgtccg 2374201 ctgataatcc tttttccctt cattttgagg taaaaaggtt tctttcaacg ccatttcaat 2374261 ttttttagcg cttaatatca aatttttcca aatcatcagt tcatggcgca ggagatggac 2374321 gcggtttaaa atgcttttgc tattgtcgtc tttaatttgc catctgagct ttctcagctt 2374381 gacttcaaat tcatcaacac cgattaaata cgcattcatt agttcgccga gaagaattaa 2374441 aaacccctct atcgcattgt ccgctctttc catttgccga acaacttctt tgcctttaat 2374501 ctctctcaaa attgaaaagt caaagttgat tgtaaaaaaa tattgtctgg tgatataaaa 2374561 gtgaaaaaca gtatggtctt tttcttcacc aagcccctga tcataaacaa tcgacccaaa 2374621 tactgcttca ttttccgttt cagttgtatc tactcgcaaa aaattaacgt gatggttatt 2374681 ttcaaaccac ttttcacact gaggccagtg agaaaaatgg attagatctc ttgccttact 2374741 tctttcttga ggccccattt ggtaccaaaa ccaatccttt cccgtatgtg ccttcatgtc 2374801 aagctcctcc aaacttttgt tctttattct ttaattgccc aataaccgcg tcactaaacc 2374861 agtctgccgc ttcaacacat gttttatgag cattttcagg tggtatggaa tgtagaaaga 2374921 catcggaaaa gggaggtgca tgccttcctt ggagaaggca gttgttttgg aatttatcaa 2374981 tttactagca gtcgctattc tcattttgtt aacaggattt ttcgttgccg tagaattttc 2375041 aatcgtaaaa gtgcggcgat ccaaaattga tcagcttgtc gcaaaaggaa agaaaggtgc 2375101 taaagcggca aagcatgtca tcactcacct tgatgaatat ttatcagcct gtcagctggg 2375161 catcacagtc gcagctttag gactgggatg gcttggggaa ccgactgtgc aaactctgct 2375221 tcgaccgctt tttcataaag caggcttaaa tgaatcgctt acccacctgc tttcactcgt 2375281 catcgcattt ttagtggtta cgtatttaaa tgtcgttatt ggggagctgg cgccaaagag 2375341 tttcgccatt caaaaagcag aaagcattac cttgttgttc gctaaaccgc ttatttggtt 2375401 ttataagatc atgtttccat tcatttggct gttgaaccac tctgcccgat tgattacagg 2375461 agtgtttggg ctgaagccgg catcagagca tgagctggct tatacagagg aagaacttcg 2375521 ggtcctattg gctgaaagct ataaaagcgg cgagatcaga aaaagtgaat taaagtacat 2375581 gaataatatc ttcacctttg ataaacgaat ggcaaaggaa attatggtgc cgcgaaatga 2375641 aatggttagt ttgtcactag atgaagactc catttcaaat cttcaggaaa cagtcaagca 2375701 aacaaaatat acacggtacc cggttgtaag agaggataaa gataacgtca ttggcgtgat 2375761 taatatgaaa gaagtgctgt tttccatgct gacgaaagat ttttcaatca agaagcatca 2375821 aattgaacct ttcgtacagc ccgttatcca tgtaattgag acgattccta tttataaact 2375881 attgctgaaa atgcaaaagg aacgcactca tatggcgatc ctcatagatg aatatggcgg 2375941 gacgtccggt ttggtcactg tcgaggatat tatcgaagaa attgtaggag aaatccgtga 2376001 tgaatttgat gcggatgaag tgcctcatat ccgcgaactt ggaaaggatc attacttgtt 2376061 aaatgcaaaa ttattaatca gcgatgttaa cagcctgctt ggaaccgatt tatcagaggc 2376121 tgaagtagac accttgggcg gctggttttt gacacaaaac atagacgctg agcctgaaag 2376181 tgccatagaa tatgatggct actcttttaa ggtaaaagac atcaacagcc atcacatttt 2376241 atttatagaa gttaaaaaag ctgaatagcc cgtgaaaggc tgttcagctg ctatctttca 2376301 agataaacat ggcaaaggca tcaacactct tttattttaa accctttatt ggccagggct 2376361 ttagcaagac tttgctctgt tttcacattc gaaaaatcca gacccagctt cacgacagtt 2376421 tgggcaattt ccggcctgat tcctgaaata atagtctcaa tgccgagcaa tttggtgctg 2376481 tcaatcactt taaaaatttg ataggctacc atggtatcaa cgataggaac gcccgaaata 2376541 tctaaaaata aatacgagag ctttaacgct gagcactgct ccagcacaga ctccaaaatc 2376601 gtcctcgctc tgtgcgtatc aatttcaccg acaagcggaa gaatcccaat tccatcagta 2376661 atcggcataa tcggcgcact caattcatta atcatttctt tttgcgcgtt taattgtatc 2376721 atggtcacct ggtgatattc ttccgtaaac acttcgatga tctcatcaat gttttgattc 2376781 aagatccggc tccactcata aaattcctga atgctgatgt cttgagaaga agcttcgctg 2376841 aatttatgaa tccattcaaa catgatgtgc ctgaaagtgt taaactggcc gacactttgt 2376901 gtaaccgtca cttcatgaac ggcacggtct ctggcgcatt gaagagacca ccggttgagc 2376961 tcatcctcta cgtcttcttt tctaagggat tttgctacga tggtcaccaa taattcatgc 2377021 tggtctttta acttttgttc tagtttttgc tgatctttcg ctgaatacag ccagctgccg 2377081 tttgacgtac aaacttccag ccattgttgc gtaatatctt ttttgtgctc tgttaagtgc 2377141 tgatcaagag ctatcatctt aatgagttac ctcctgtttt tgaaaaatgt acgctatata 2377201 tgtataacgc gtctgccttt acacatacta tgtttagatt caatgggcta tagccaagcg 2377261 gtaaggcaat ggactttgac tccgtgatcg ttggttcgaa tccagctagc ccagtttctg 2377321 aacaggtgaa aaaccgaaga taagctgatt cgtataaatc agcggatctt cggtttttca 2377381 tcatgcagat tgatgaaccg ttttcttctt cgataacttc aacagttctc ccgggttata 2377441 accaatcacc agctttttgt tgtctactag aatcgggcgt cgcaaaagct tcggcttctc 2377501 gattaaaagt tccagcacct catttaccgt catttcttca atgtttaaat ttaaattttt 2377561 gaaagtctgg cttcttgtcg ccaaaatttc atcaattcct tctgtcgtta acgataaaat 2377621 gtactttaat tcttctcttg tcggggtttc tctgaataag tgccgttcgt taaattcaat 2377681 ttgatgtgct ttaagccaat gttttgtttt tcggcatgac gtgcagcttg gatatgagta 2377741 aaaagttaat tgttgttcca ttcgtttttt cctcctcagt taaccatctc tttgtagaat 2377801 aactacccgg atcatttttc atttaaacca tttacagaac ttttttcgga ttatttttta 2377861 aaaaacattc atacaataga aaacacaatc aaagggacaa attccatttg tatattaata 2377921 atgaaaatgt ttacatttct aggtgtgatc tattataata acagtcagag ggactctcgg 2377981 gaggggataa aaatgaatcg catgttccgg gtgttaggat tttggacggg aatttttgca 2378041 gtcatgtttt atttaggtga tatgaaagat gcttcccttt tattttttgg acagacgatc 2378101 ttatttgtgt ttctatcgta tttgaactta accgaacgca tgtatattta tatttttggc 2378161 gcttatttaa caattttctt cgccggcttt acatattact caatttttat tatggtgccc 2378221 ggcggcggag gccattaaat gcagaaagag acaaacctta tcggtttgtc tcttttttta 2378281 caatgaaaac ccatttaaaa acggattttg atcctgctca gtcagtacgt ctgtttcagg 2378341 tccatggccg cttaacacca gcgtgtgttc cggaagcgta agcagttttt catgaatgga 2378401 cgtcagcagc gtctcttgat tgccgcctat taaatccgta cgtcctatac cgccttggaa 2378461 caagacatct ccggaaatga ccaagtctgc atctttcacg tagtaagaca cactgcctgg 2378521 tgaatgtccc ggcgtaaata atgtttccaa atgaaacggc ccgatattca actcaccgtc 2378581 gccttcaatt agatgatctg caggcttagc tgtgacttct atccctcgca gcatgccgga 2378641 gccgtttaaa gaagcgtccg caagccaatt tttttcattt tgatgcaggt aaacagggat 2378701 atcccatttt tctctcactt catcaagcgc cccaatatgg tcaaaatggg catgtgtaag 2378761 caaaatggct aaaggcgtca gccctttttc ttttatgtat tgattgattt tatgtccctc 2378821 gccgcccgga tcaaaaatca gacattgatc atcactgatg agaaaatatg cgttcgcttg 2378881 aatcggccct actggcattc gtctccattt cactattatc acctctttct tttttatgct 2378941 cttattatga gggtttttga aaaaagattc aaacaatcgc aatgaaaacg ctatcgacaa 2379001 acctataaaa aacaggtaga ataaaactgg aaagaattgc aggtttttca atgtaaaggg 2379061 ggctgtgtta tgttacttgt cgtgattttc ggccttgtcg ctcttttcgc tttatgggga 2379121 gtcttgcgtt ctgttagaaa taaaaatata ctcgggtttt tattagccgg tgccacctta 2379181 tttgtctttg gatggtttac cgtgatgacc gtaataaaca gcgggtatcc aaccgcacat 2379241 taaaacctgt atccgatcgg atacaggttt atttttatgg ctgtaaatgt ttattgacac 2379301 tttctatttt gctctcaagc gtcgtttttt tgtcacgcct gtcatcgata cggatattcg 2379361 ttgccactct gtgcaatcct ttttgaaatg gcgcttcgtg aattgcctga ataactgcaa 2379421 aaaggtcact gagttctccc tcgatcagcg tattcatcgg tgtcagctga tatttgattt 2379481 tcccttctgc ttgatatcct tctaatatct tttgcacatc ggctacgtaa gcactgacac 2379541 tgggtgtttc cgtaccgatt gggataatgg ttacatctgc gatagccatc gttattccat 2379601 ctccttttga tcaatgatga gttgcttcgt ttcatgtgat ttcaataaaa taatttgctc 2379661 aaaatgaaag ccgtataacg catatttccc gttcggagat atttgaatcg gctccatttc 2379721 ccgcagagac acaagatctt ttgtctctcc cgatgctaca ttgattgctg cgagcttata 2379781 tgcatcgccg ctttgtttga atgtataaaa caggcctcct gcttcatcat agtcatactc 2379841 cattggagcc aaacttgtat atttcgcttg gagcggccat ttcgctgtaa caggtgatgt 2379901 tgattgcggc gttttaaact gatacgtccc ttttcctccg gaagctgatt tgacagtaaa 2379961 actcatttga tggaaagaat cgaagaatag aacgttatcc tcaagcttct gttccgtctt 2380021 agaagctgta tcgaacgtat ataaaggccc tgttttatcg tctctaccct cttttacata 2380081 atcaaatgta tttttggatg tccaatgaat gaacggaacc tgtactgggc ttaagaaaga 2380141 ttcgtctttt ttagcattca cctgatatgt atggaaatcc cagttttcat tgaattccgt 2380201 caccatcatt tgataaggat catactgatt ccaagcagct tcaagctcat acgtttcgta 2380261 atctttttcg taaagcgtct ctccttctgc attaagcaaa accactgccg tcttttggct 2380321 atgtgtgatt tgcagcagaa tcatctgctc cctcgcattg atttgaacat caacgatttg 2380381 accatccgtt tgatagagct ttttcgcttt gcctgtaaag atgcggtacg caaaaagctc 2380441 tgttttcgtc ggattagacg cagtatataa tattgtgctg ttattcagcc agccttccgc 2380501 cccatccgct ttttccgcgg aaagcggtat gatgtctttt ttctcatctt ttgccgccga 2380561 tgcctgtttt tgctgctgat gagatggttc gcatgccgat aaactaaaca gcaataccgc 2380621 cagcagaata aaacaaactg atctcatcag cattcccctc cgatcatctt tattctctca 2380681 tatttgcttc ggcagaaaaa agaaaaagtt tcagttactc atgaaaaaat aacgccctcc 2380741 acaagatacc gcttgtggcg ttatatatgt gtgaaaactg ctgaaacggc aaaggatttt 2380801 ggccttttcc aagttccacc gtataccctt ccttaaaata atggtgaata aaccaatcac 2380861 gaaatccagc atagctgtct atatccctta ctcccttata aatgttcccg cttaactcct 2380921 caaactcctt tatgacggca gcagattcct caggctcaag gcctttatag ccccaataaa 2380981 tttcttctcc ttgagtatga agagccagca gtctgtcagg cggattctcc gtgatcagcc 2381041 ggtacatcgc aatagattcc ggctccgtaa gcggagagat tcccggaaaa tcgcggtagc 2381101 tgggtgctgt cggttttcgg tatttttcaa tttcccataa tgatggaaat tgtttattta 2381161 aatcaacccc gtttatattc gccttccatt cattaaaatt tggacgatgt tcatttagcc 2381221 tttcgagttc atctcttctg gctcccatga cttctgatcc gtttaaaaca agatcaacgc 2381281 catccggatt gacaagagga acgagggata aggatgtgct gttaaacagc tttatgggag 2381341 aaaagccaaa gaaaggcgaa ttgcagcata atgacataca gtattcctta aaccatttta 2381401 gcaggacaga cgttgtaatc cactcattcg catgaaatga cgcgttcata tggacctttt 2381461 ttacggcatg ctccccacca gccttcagct cccagatagg cctgccgagt acagaacggc 2381521 caatttcccg gcatgagaca aacggaaaaa catcaataat cttctttatt tccttttcaa 2381581 cagctgaatc atcatagatt ttctcttgct caatccagct atctgaaagt ttcagctgcc 2381641 gaggctgtaa aaagcgcttt atgtcctgaa tggtttgaag ctctttgccg ctatgctcct 2381701 ctatcacata accagggcaa tacaattgat gtttttgtgc ggagcgattt gcacttttaa 2381761 gcaattcctc gtctatcttc agttctttcg ccacattggc caaattgttc ttgatctcag 2381821 gtttcaccgt aataaacgcc atcatcatcc cccttttttg ttactatatg acagcgtatt 2381881 taaaaaaaga aagcctcccg ctcacttcga tgcgggagac attgtgatta tgatgcctga 2381941 tcaagcattt gtttttcttt ccgctttgac gaattgtcca gccttttctg gtcataaaat 2382001 cgcaacaaat ccccataaat gatttcatca gaaagtgata gctcctgttt tgctttatca 2382061 gcaaatgctt cacattgttt tgtctcttct aacggttttc ccgtctcttt gtcataacac 2382121 gcaccgtctg tataaacaac ctgatctgtg ataaagctcc cgtcccggag caccgtgaag 2382181 tccagttttt cgtctgaaag cagatcgttg ccgaattgaa tttgatcttt cgtatcaatc 2382241 cctaaaagat tcatcagcgt cggcctgata tcaatctgcc cgcctactgt ttcaatggtt 2382301 tgcggctttt tatcagtaat acccggaata tgaatgacca gcggcacttt ttggagctgt 2382361 acctcttcaa atggggttat ttcttttcct aaaaactgcc ccatcgcttc attatggttt 2382421 tctgatatac cataatggtc accatataat acaataacag agttgtcgta taacccgtct 2382481 tccttcagct tttcgataaa ccgtttcagc gcctcatcct gataacgcac tgtcggaaaa 2382541 tatttattta gcgtctggct gtttgaatca tattcatcaa tcaattgatc ctcttcatca 2382601 agatcaaacg ggaagtggtt cgtcagtgta atcagcctcg agtaaaacgg ctgaggcaga 2382661 tttttcatca gctctgagga ctgctcaaaa aattctttat ccttaagtcc ccagccgact 2382721 gaattttcgt cagttacatc atacgagtta atatcaaaaa acgaatcata tccaaatgag 2382781 tcgtacatta aatcacgatt ccaaaagctc ttattattag cgtggagcac cgctgaatag 2382841 tatccgctgt ttttcaaaat ttcaggagcg gccatatatt gattgcccgc attcgtaaaa 2382901 aatacggcac ctcgtccaag cggatacagt gaattgtcca cgataaattc agaatccgag 2382961 gttttcccct ggcctgtttg gtggtaaaca ttattaaagt tgtagctctg ttttataaag 2383021 tcattcagaa aaggcgtgat ttcttctcca ttcaattttt cattaatcac gaagctttgc 2383081 gtcgactcta aggatacgag aatgacgttc cttccttttg cagcgccgaa taagcgtttg 2383141 ttggcatcct tcgcattagc ggttacgtag ttttcaatct ccgtcaggct gttgctgtct 2383201 gccaacgctc tctgtgcgga ttgctttgac tgaagaacgc catcgtaaat atgaaaatta 2383261 aacaggctaa tgtttttaac aagcatttct ctgtcaaatg agcgtgtcaa tagctgaggt 2383321 ctttccgcct cagacaagcc caggttgaag aaataaacag aagcaacgaa caaaaaataa 2383381 gccgcccgtt catttttcgt tgagggaatg tccgattgaa aagctttttg ccggatgtga 2383441 agccatatta aaaccgcaat atctacagct aataggaggt ctgtcggctc aagaagtgtt 2383501 ccgatgctgc ttccgagatc acccatattg ctcgtttgaa aaagaacagg gattgttaag 2383561 aaatcattgt aaaaacggta aaaaaccata tttgccagca atacaaacgt gacaagacag 2383621 ctcatcgcga taatgtagcg atttctgttt ttgcctttta aaaacaggct gaggccaaaa 2383681 ataagcaaca aaaaactcaa tgggttgata aacagaataa attcctgtgt tagattgtcg 2383741 attttaatat gaaaactggt tttgtaaaca gcatacgttt tcagccacat caataaaatg 2383801 gcaatcagca taaatgaaat cttcgaaaaa aacgtttttc gcatttcaac ctcctatgca 2383861 gcacgctcaa aaaaatcagt ctattcccaa cattctcatt aacacatcaa attaaatctt 2383921 aacctgagca caacaaaaaa tcaatttcat ttacacaatt ttaacaattt tgatgtttca 2383981 gccattcatt tttagcgatc caagcgcctc cgataacgcc ggcatcattt ccaagtgctg 2384041 cgattgaaat atcagcagct tgggctgccc gcggaaacgc gcatttgcgg aatgttttct 2384101 cgacttttga tctcagcagt tctccggctc tcgatacgcc gccgccaaga acgattttgg 2384161 atggattaag cgagcttgcc aaatttccga gcaccaaacc aagatgcttg gctacataat 2384221 caaccacctc aagggcaatt tcatcatttt cacccgccgc ttcaaacaca tctcgcgctg 2384281 acaattgttc ggttgctttt aaacgtgtcg tctttttagc atttgctatt ttttcttttg 2384341 caattcttac aattccggtt gctgacgcaa ttgtttcgat acagcccgtt ttgccgcagt 2384401 tgcagggcgc tccgccttca gggatgctgc aaatatggcc gatttctccg ccggcgccat 2384461 ttataccatg tacaatttca ccatttgcaa tgatgccgcc gccaactcct gtgccaagcg 2384521 tcacgagaat gacgtctttt gcgccatcac ccgctccctt ccacatttcc ccgagcgcag 2384581 caatattcgc gtcattttct ataacagctg ggatgccggt ttctgtctcc agatggtttt 2384641 tcaaagcata atttttccac cctagattta ctgtttcata aaccactcct gccgccatat 2384701 ctacagggcc tggtgcaccc attccgatgt atttgatgat gtgcttcggt ttttgcagct 2384761 catccagctt gctgtcgatt gtttttgcaa ttgtgacagt aatcgtgtcg ccggttttat 2384821 ctgtcggaac ttcccactta tgctgaattt cgccatattg attaataaaa gcgagtttaa 2384881 tcgtcgttcc tcccaggtca atgcccgcaa accatatctc gtccattttt atcaccttag 2384941 cctttataaa aatctcttcc gttttttgtt tgttccaatt cttttcgaag gacagctgcc 2385001 gctctggccc actgctcctt ttcaatcatg tggttcatgt ataattcctt taattcatcc 2385061 agcataaact caatttcaag ctctctgtct ccaaaataaa caatgtggcc aaacgttttt 2385121 aacagctgct gcacatcata aaatgtattc attttcctca ccatttcttg aacttaacta 2385181 tcataagcgt attcataagg aagcggtcag tcaagaagaa aacgctgaca aaaaagccag 2385241 cttcctttcc atattccacc tctatgattc tttattgttt tcaatttgcc gctgcagctc 2385301 cttgtagcgc tgctccttcg gcttcagttt cacagccgtc tggatggcct tttctgcttg 2385361 tgcaagctca tttttttccg catacaataa cgctaaattg taataggaag catggtcttt 2385421 aggttctttt ttcactgctc gttccaaaag ggaaaccgcc tgatcatatt cgccgatttg 2385481 aatatcagaa acagcaagaa ttttcaaaag atcggcagag gcatcttttt gcgctgcttc 2385541 tccgttcagc aattctgtta cttcttcata ctttccttcc tgatacagct cgcttgcctg 2385601 ctgaatcagc gctgactcct ggtgtgaagg cgaatgcaat ccgtaatata aaaatccaac 2385661 agccaaagca atcagcaaaa ccgctgacaa caatcttttt ccaaaggctc cggctttagg 2385721 caaccccagt gctgctgcag cgaaaaagcc gccaatcaag ccgccgatat gtcctgaatt 2385781 atcaatattc gaaaccgcaa aaccaaagcc cagattgatg ataataatga caataatatt 2385841 ggttcctata gttcttaaaa acatttttcg attagacaaa gcaacataca gtaatgcacc 2385901 taagcatccg aatatggctc ctgatgcccc tgccgaagga tacgggctga acacaaaact 2385961 cgcaatcgaa cccgtaatgc cagcagccag ataaatcagc aaaaatctcc ccgatccata 2386021 catccgctca accgctgtac caaccgacca taaagccagc gtattaaaag ctaaatgcgc 2386081 tatgccgatg tgaagcacga tcggtgtcag aagccgccac cattctcctt gtgcaatcag 2386141 gctgttttct tttgctccaa aagccaccag tgtctccgta ttagtgctgc ctccgtttat 2386201 ttcgagcaag aaaaacatca ggatctgaag cgcaataaat aaatatgtaa aagtcggttt 2386261 tccgttttga aaaaccgccg cttcagtttt tctctgttct tcttgtttca gcactagcga 2386321 aaggaagcgt tctcgcgcca tttgcgcgtt ttcaaacgaa gcgtgttcct ctgaacaatc 2386381 ttctgtacga aatgatggaa aaaccgcttg aagatcatct cgaagcatcg ttcctctaac 2386441 gatcgccggc tcaactgaca cagttccctt ctcaaaagtt ttttttgcaa tctcttccca 2386501 gtcatcaact ggggcttccg ttgaaaaaaa cacgttcagc agcttcatcc ttcgtctgcc 2386561 caattgatgt ctgactcgtt ctactcgttc ggcctgctct tcgatgtctc taaccatttc 2386621 ttgacggaaa tcaagatcgt gcttataaag acgaactaga tcatgagagg acttgtccgg 2386681 cgcttccagc catatttcat ctgactcacc ggcttgtatg acgccatacc cgctattcac 2386741 caggtgcgcc gcaattttcc aatatgtata ctccagcaaa aacatgttta ccgctccaat 2386801 agtttttttt cattataaca gctggcgctc cgaaacgcct actgaaagca aaaaatcccg 2386861 tttttcacgg gattttagaa agcttgctgt ataaacttat tgcggataaa tggaattctt 2386921 aaaaacaaat ggataaaaga ccgcctgatt cctggctggc tgagtacagt attcataaga 2386981 cggtagcgat tttgataaaa catgacggca gaaaccgcga aaatggcata tatcaaaagt 2387041 tttttcatga tatccctcct gccaataggg tttgttattc taccttattt attctcgaat 2387101 aagggacagg aaagttatga aaaacaagaa ataatccgat cctctgttat cagcttatgt 2387161 accgggatgt catgcggcag acggggtacg tgcgcaaaca actggcactc caaaagcaaa 2387221 gagactgtct tcccttcata ttcacttaaa tagcgatcat aatagccgcc tccaaagccg 2387281 accctaaacc cgttaacatc aaaacaaaca cccggaacga tcatcaagtc aatttgtgat 2387341 gggtttactt cttttgtttt ttcaattacc ggctcgagca gtccggcgta cacggtttcg 2387401 agctgatcat cagtctgata tgtgcgaaat tgcattttct tcgtgtccgg atggcatttt 2387461 gggatgcaaa cttgtttccc ttcttcccaa gcctgctcaa tgacaggacg cgtcggtatc 2387521 tctaatcctc tggaaatagt gacggcaatg gtgccggcat tttgccactc cggcagagaa 2387581 aacaagtact tatacatacg ttccgttttt tgaagaatat cttcatttga taaagcagac 2387641 agtgcctcca gcgtcttttt tcttaattgt gatttcatct ctcatccccc tcggaataga 2387701 aaaaaagcca gaaccttttt caaagctctg gcttttttct tacacctcaa acagcaaagc 2387761 tgttattttg tttcacggtg taacgtagat tttttatcac gtgggcaata ttttttaaat 2387821 tcaacgcggt ctggattgtt gcgtttgttc tttttagaaa tatagttacg ctcaccacat 2387881 tcagtgcaag ccaaagtaat attaacgcgc attattttcc ctccaaacta aaatcattta 2387941 cttattcaga cttatatata ataccactat aatggacgga atgctaggct gtttttcaat 2388001 gaattgctga attattgaag atacgctcat aaagctgcaa atatgatgac ataatgagtc 2388061 gggggtggtg gagcttgaac acttgttgtc tgccagcttc ttttatccgg cgggcttttt 2388121 cccggtcttt taaaaaactg tccagcagat cagcagcttc ctgtacgagc gtaaaatcag 2388181 cgatgattgc cgttttgtca tgaaccgcat aatcacaaaa accacctgac tgagaaacga 2388241 cagtcagcac accttgttcc atgctttctt gcgcggcaag cccaaacggt tcataagaac 2388301 tagggaaaac agccatttca cagtgagaca gtaacgttct gatatctttc ctatttagaa 2388361 acggcagaaa catgacgcga tccttcaggt tatatgccgc agccaatttc tcatagcagg 2388421 acagagacgg cccctcccca gccagcacta gatagaggtc aggctgacgc tgcttcaaga 2388481 tggcaaacac ctttaacagc tgcgataatc ctttttccgg aacaaacctt ccatatgaaa 2388541 agaggaatct tctattcatg cttctcggga ttttcccctt ctcttcctcc atagatgcag 2388601 ggcttgggat aacggttatt ttcttatgtg ccgccttatc aagagaccgc ttcataaatg 2388661 tgcttaatac gatcaatgca tcagcggatt ctataaggag ccgttcggtc atgagcctgt 2388721 atgggtgtgg ggcttctcgg cacaccttct tcctttcgct ttcaagaccg tggattgtcg 2388781 cagcaagcgg aaggccaagc cgttgtttca aatactgggc ggcaggggca gttgtgtcat 2388841 catgggcatg aatcagatca aagcgtttat tgtgtgataa cacatggcga accattgtaa 2388901 agttagcatc agctatgtaa tcttcaaact tcgcatacga aaacagctgc ccgctcggag 2388961 taaaaaccgt aatgttgata tgagggttta aataggaaat gaggcggttt aaatggacac 2389021 cgagcccgct tttcggctca tcgggatgtt cgggtgaaag catgagaatg ttcaccgttc 2389081 tttttcccct ctcccataac aggtgtatgc agaaaattgc gcctcccacc tggtgtgcgc 2389141 ttcttcaatc tgaaaactgt ttatatgacg aatcccattt tcatcaagat agatgtcgtc 2389201 tgtaccggca agcttgagag agacattcat tgaattcaca attctgtatt cagcccgata 2389261 tacagcatca ccagccgcct gtctaatcgt ccattctcct ttatcatacg ttgtgcgttt 2389321 tgtcctgaca gcttcaatgt cttttctttt gatgacaatg cgcaattctt ttatcatatc 2389381 ctgcgttttt tcgaaaagga ccgcttcagc cagccgcatt gtttcttctg agatttccca 2389441 gcttacggtc aaggtgtgag cgttttgaat gattatgtcg aatgtgtccc taaaaaagga 2389501 aagcttatgt cgtatattat agggaaatgg gtgtttatcc atggactcct aacattctcc 2389561 tttccaatcg ttcacttcgt gttcctatta aaccattaca tgaagaagaa gcgaagaaag 2389621 atttctcgac aaaatctcgt ttttttcgcg aattccttta gaaactattg gttttatggt 2389681 ataaaaaaga aggataaaaa aagaatagaa ggtgatgaaa cgtggaaatt gctattattg 2389741 cgttgtttat cgtcagtata gcgctaattg cattctcata ttctcaaaga gacccgatga 2389801 aagatgtaga acaggagctc gaaacactgc agctttctgc gatgcaggaa atttacaagc 2389861 tcaaaaagaa aatgacagtg cttgaggaag aattactgga aacaaacctt gtcattcgca 2389921 aatcaaagca gaacgacatc aatcaaaaaa tcgctaaaca aatactttct aaatataata 2389981 acggtatgtc agctgaagcg attgctaaag ctgaacatgt atcagtggaa gacgtgaata 2390041 cgattatcaa agataatgag aaggtgctcg tatgacaaaa cggggcattc aggcatttgc 2390101 tggcggcatc attttagcga cagccgttct tgcagctgtt ttttatctga ctgacgaaga 2390161 ccaggccgct gctgtaaaag ataataaaac agtaaccgaa caagacgtga acaattatct 2390221 tgattctaaa aaattggttt ctgtcaaccg tgatgaatat caaaaacttc tcgattcaaa 2390281 agagaaatcc ttaaacaatg acagcggctc agacacgaaa tcagacaaag tcaaaaccta 2390341 caagctcacc attaaagacg gcatgagcac ggcggatgta tctgctattc ttgaaaaaga 2390401 gggcattatc tcttcggctc aagactttaa tgactatgtc attgatgccg gctatcacaa 2390461 agaaattcgt gccggcgagt ttaaagtaaa atcagacatg agtttcaaaa agatcgtaaa 2390521 aacgttaaca cgataaaaaa acaggctgac tcagcctgtt tttttcatcc aaactttcct 2390581 gaaatgtaat cgagcgttct ttggtccttc gggttagaga acattttatt cgtattgtcg 2390641 cattcaacaa gctcgcccat gtagaaaaag gcggtttgat cagaaaccct tgctgcctgc 2390701 tgcatgttat gcgtgacaat gacaattgta tatttatctt tcagctctag aatgagttct 2390761 tcaatttttc tcgttgagat tggatctagt gcagatgtcg gttcatccat cagcaaaata 2390821 tcaggattgg tcgcaagtgc tctggcgatg caaagacgct gctgctggcc ccctgacagc 2390881 gaaagagcgg acgtatgcaa tcgatccttc acctcatccc ataacgccac gtcttttaat 2390941 gacttttcca caatttcctg aagcttcttc ttatttttgg tgccgtggac tctcggtccg 2391001 taagccacat tatcaaaaat agattgcgga aacggattcc ctttttggaa taccatgccg 2391061 atattttttc gcaaatccac gatgtccact ttatccttta aaatgttgct gccattatag 2391121 ttcagctcac ctgcaagctt tacattcggc gtcatttgaa tcattaaatt caatgtcttg 2391181 ataaaggtcg atttcccgca tccggatggt ccgataatcg ccgtaacctc attttcataa 2391241 atgctcaaat tgatattttt taaagcatga tgctgcccat accataagtt cattccattg 2391301 acttgatata cttcctgttt cattacagct tcggtagcaa tactcattgc cgccctccta 2391361 tccgaatttc ccgttaatat aatcctctgt cttttgcttt ttcggactcg tgaaaatctg 2391421 ttcggtctgt ccgtattcta caagctcgcc gtttaaaaag aatgccgtcc ggtcagaaac 2391481 ccgcagagcc tgctgcatat tgtgcgtgac aataataatt gagtattctc ttttcaatcc 2391541 tgtaattaat tcctctattt ttgcatttga aatcggatca agcgctgaag ctggttcatc 2391601 aagcagaaga acagccggct tcatcgcaag cgttctcgcg atgcataaac gctgctgctg 2391661 gccgccggat aacgagagtg cggatgaatg taaacgatcc ttcacctcat cccagagcgc 2391721 tgcttttgtt aaactttctt ccacaatttc atctaaaaca gctttattcc gctctccggc 2391781 atatttcaat gcatgtgtga tattcgcata gatcgatttc ggaaatggat ttggtttttg 2391841 gaaaaccatt ccgatttctc ttctcaagct gacaacgtta atattgccgc ccaatatatt 2391901 taatccctca taaaggattt caccttccgc tcttgcagat ggaattaaat cgttcattcg 2391961 gttaatattt ctcaaaaaag tagattttcc gcatcccgac ggcccaatta aagcagtcac 2392021 cgcatttttt tcaatatcca tgtttacatg atgaacggct tgtttatttc cgtaataaat 2392081 ggacagatct ttgacctcaa gcacgtggtt ctgcttcgga acaataacag ctcgctcagg 2392141 tttttctttt accatttgtt cagacatgtt tttcgcctct ttccgttcta atttgccgta 2392201 agctttttgt agatcatcgt gccaagccat ctcgccgcga gattaaacac aagaacagaa 2392261 atcaccagca cggcagaacc accgttggca atcgcttcag catccggaat cattccttgt 2392321 gtattgacgt tccaaatgtg gaccgcaagt gtttcagcgg gcctgaaaat attaagcggt 2392381 gatgtttccg aaaacgggtt ccactccgta aaattaagac gcggtgttgt caggcctgcc 2392441 gtaaataata atgcggccgc ttccccgaac acccttcctg acgctaaaat tgctcctgtg 2392501 atgatagaag gaatcgcact tggaattaaa actgttttta cggtatgcca gcgtgataca 2392561 cctaaagcga gagaggcttc cttcagatct ttagggactg aacggatcgc gtcttctgtc 2392621 acacgcacca tgacaggaag gttaaaaaca gttaacgcaa gcgctccgcc tatgatcgta 2392681 taaccccagc ctgttaagtt gacaaacatc aataatccaa acatcccaat gacaatagac 2392741 ggaagagatg aaagcacctc tatacatgtt ctaatgaagt cagttacttt gttattaggc 2392801 gcgtattcag ccatgaagac tccgccgccc acaccgagcg ggattgtaat cagcattgta 2392861 ataaacaaaa tataaaagga gttaaacagc tgatctcgta tgcctcctcc agctgcaatg 2392921 gcgctcgact ttgttgtaat aaattgaaaa ctgagctgag aaacaccgtt tataataata 2392981 taggaaaaca aacctactaa aatggcagcg ataatggctg cacacaaacc aaacattccg 2393041 gtcgccagtt tatctgttat tttgcggttc attacacttt cctcctagat gacaagtagc 2393101 gaataagcag gatgaacaag aatgacatca ccagaagcac aagccccatt gaccacagcg 2393161 tattgttttc aacacttccg tatgtggtgt ggcccatatt cagcgtgatg atcgttgtca 2393221 gcgttcccgc agtgtcaaac gggctttccg gcaatactct tgtatttcca atgaccatct 2393281 gaacagccaa agcttcaccg aacgcccgag ccatgcctaa cacaacagct gtcatcaatg 2393341 ttggaaaagc tgcaggcaca agtacttttc tgatcgtctg ccatcttgtg gcaccaagcg 2393401 cgtaagaacc ctctcgtaaa ctcttcggaa gagaagccat tgcatcagca gaaatcgatg 2393461 tgatcgtcgg cagaatcatg acggaaagga caatcgttcc cgccaataaa ctgtgccctg 2393521 ttccgctcga tttgaactgg gcgataaacg gcaccaatac tgtaagacct atgaatccat 2393581 aaacaacaga tggaataccg actaaaagct caatcaccgg ctgcagcact ttctttcccc 2393641 aattcggggc aatctctgtc ataaaaatcg cacctgcaat gccaagcggc gcagcgatta 2393701 gagcagaaag aatcgttact gcaaatgagc caaaaataaa tggcagcact ccgtatttcg 2393761 gatcactatc tgtaggattc caatttaagc tcgttaagaa ttcaattggg cttacaccat 2393821 ttacaagaaa agattgcagc cccttaacgc cgaggaaaat ggtaatcgca acagatgccg 2393881 caatcataat cagtgcacaa gctgtgacta tcattcttcc ccgaacttca tccaattgcc 2393941 gattttgcct agagctgatt aagcgctcgc tcacagacat attttctcta ttgtttatca 2394001 ttgttttaca ctcctatgaa tgtgttaaga ggagaaacgg ttgtccccgc actcctcttt 2394061 ttattaagat cagctttgct tcccgttggc atcacgtgtc actttcatat cagtaaccgg 2394121 aatgtagcct tggtcagtaa caatgctttt ttgaatgtct tcactcttta gataatcaag 2394181 aaattcttta gctaaacctg tcgcttcacc ttttgtataa gaatgttgat aagcccagat 2394241 cggatactcg ccagttgcta catttttcgc ttcaggttta acaccgtcaa tagatagagc 2394301 agttactttg tcatctgtta aatatgagaa tgcaagatat ccaatcgctc ccggagtatc 2394361 agcaatgatc tttttcaccg tgttggagga atcttcagta atgccttctg caggctccgc 2394421 tccgtcaagc gcatatttca caaatgtagc acgtgtgccg gaagaatcag ggcggtttac 2394481 aagtgtaatc ttttggtctt tgccgccgag ctctttccag tttttgattt tgccagtgaa 2394541 gatttttttc aattcatctt ttgaaatatc ctttacacca gcatcagggt ttacagctgc 2394601 tgccatacca actacagcga cttgatgatc gacaagcgct tttgcatcga tgccttcttt 2394661 ttcttcagca aaaacgtctg aattcccgat ctgaacagct ccttcagaga cttgagaaag 2394721 ccctgttcca gaaccgccag cttgtacctg tatatcagca tcagggtttt cttccataaa 2394781 tttttccgcg gctgcaagta ctagtggctg cattgccgat gaaccagaaa tggttaaaga 2394841 acctgatgcc ttttcttctc cttttgcaga atcgctattc gattttttac tttctcctgc 2394901 atttccgcat gcagctgcaa tcatcataaa agcagccatc agaagcataa gcaccaattt 2394961 gttttttttc atttcctgaa ttccccctgc gtataatgtg taatttgtcc tacacgtata 2395021 gagtaaaggt tctatgtaaa aagggtttga accgaatgtt aaggttttgt aaatcagtgc 2395081 gttttttgta taaaaaaaac gcccacatca tgtgagcgtt tttttttagt tatcagaaga 2395141 cgttgtgttt tctgcatttt cttcaatttt gtctttattc ttttgctgag taccttcttt 2395201 gtcctgcttc gatttcagct caaaatattt atccattact tccctgccga tttcgtttgt 2395261 aattgagtat ctttgattgt aatcaatgta agtccaagga actacgacag aaatagcaat 2395321 ctcaggattg tcagctggtg cataagccac aagcgtcgta ttataagtgt ctgttcctgt 2395381 ttttgattta tccggtccgt cgtaaaatga ttgggctgtt cctgtttttg cagctggttt 2395441 atacgatgct gaagccagtt gacctgcagc tgtcccttta gtggcaaccc gtctaaaacc 2395501 ggcttggacc tcttcaatat agctactctt catatcgact ttattcaata cttcaggctg 2395561 aacagaatca acgactgcgc cgatcccttt tttcgcattt gaatctctga cttcctttac 2395621 aagctgaggc ttcatgcggt agccaccatt tgctatggtg gagacatatt gagccaattc 2395681 cagcggtgta taagtatcat actgtccaat ggcgaaatca agcaagaaac cagataatct 2395741 gcttgtacct ttatatcccg tcatttcatt tggtagatca attcctgttt ttactcctaa 2395801 tccaaattga ctgaaataat ttctgaaggt atcaaatgca gaagtatcca aaggcaatgc 2395861 ttggtgaggt ttatattcac ctttaccaac tgcaattgct gttttaaaca taaaaacgtt 2395921 tgatgacttc tctaatgcag tttgaatacc aaccggccct aagttttgcc aagatttttt 2395981 ccctctttta tcctggccga tatacaatgg ttcatcctta aatacagtat tcaaattaat 2396041 cgctccagtt tgaagaccgg tcaaaacggt tgcacctttt acagctgatc ccatagcgta 2396101 ggatgaagtc atggctccta atgcataatc atcaaactta taggctccat tttctcgttt 2396161 aatctgcttc cctgccattg tcagcacttc gccgtttcta gggtccatca tgacaacgaa 2396221 tgcacgatcc aacaattcgg tactaggtct tgctttagca gctttaagtt ttttctcaat 2396281 aattttttcc actgattttt gcaaatcaat atcaattgtt agtacaagat ctttcccggc 2396341 tttgccttca gataccgttt ttgttcccgt gacattgcct tttgaatctg tgatattttc 2396401 gacttttgct ttttggccct gcagaaggct ttcatattgg tattccagat agctttttcc 2396461 gaccctgtca tttcggctgt agccaagcga cagataatgg tcgagcaagt tggacggcaa 2396521 tccttcatta gagctggaaa cacttccgag cactgagcga agaaggtttt tataaggata 2396581 ttcacgttcc caatcggacg tgacatcaac acctggcagt tcgtctaaat gttcacttac 2396641 cactgccatt tccttcgctg atacatcttc gtttttgata tattgagggg tcaatgcata 2396701 gcccgaatcc atctgtcttt tgatagcaag gatctgcata tctttatccg tcaattcatt 2396761 cagctgctta tcagtaatcc gttttagctg aagctggtat aaatcgtcat cggatatttt 2396821 tttgtcttca acctgctgtc tttctttaga gctaatgagc tttttcgctt ctttcggtct 2396881 agtcaaaatc caataatctt ttttatcccg ttctgttact ttttttgtat cgactttgat 2396941 catgtcagac agcttttttg cgatctttaa gcgctgttct tgcgtggtcg atttagatct 2397001 cgtgtatgtg attgcattta aagccttatt tgtcacaatg gcattaaagt ttcgatcata 2397061 aattttcccg cgtggtaccg ctgagctgac ttcactttgt tcctgcttat tcgcttggtt 2397121 tttgtaatca tcaccttgca cgatctgctt gatgcccagt tccacaataa tccaggtaaa 2397181 tataacaaag gcagctaaaa ataaaatatt cagccggatc ggaagcgact tctttttctc 2397241 tttatgattt tgcttttttg gtttatttct cctcataaca tcaccttttc tatttacaga 2397301 aagaaaagac actcaagtaa gagtgccagt tttcatttta aaggtttttt cgactttttt 2397361 ctacagataa cccctttttg gcaaaaaaat tatctctcgc cttttaaaag ggtcggttct 2397421 gttacccgtt tttggccgtc ttcttccatg gtttcatttt ccccttcttt ctccttaaaa 2397481 cgaatatcct tgacaaagta ataaatcaaa ggatgtccta tacccaatat cgcaagtgac 2397541 aaaggaattc ccacatcctc tttcagaagg gccacaatca ggagaaagca caaaatggaa 2397601 acaattctgc cggcgttcaa gaacatttct ctaagcacga tatattcaat tcttgctttt 2397661 ctggcatgcc tcgcgcgccc tatcacatca tatgtaagtg atacatatgg cacaagcaac 2397721 agaggatagc cgatggcaat aaaaacgccg tacgttaata atgtcgaaaa gctcatatgg 2397781 aacagaatca aaaacagcgc gccatacaaa ataagtccgc ccagcaaaat cgattttttt 2397841 ctcgcctttt tcttaatcag cctggatgca aagtagtagg caaagaagga aacagctgaa 2397901 ttgacaagac cgaatgtacc gagagcaagc tcgctgtttg tctcaataaa tacaaacaca 2397961 ctgattaaaa agacaaaaat cccttctctc aaaccctgaa aaaaatgcgc attcgtgatt 2398021 ctccgccaat tcatattgct atggcgctct ccaaatactt tgctcagcat aaaacggccc 2398081 tttgattctc tccgttttaa gaaaaagctc atcacgacag ccagggcaaa taaactgagg 2398141 gagagactga aaatcactgt ataacccgta ttattttcaa gccttgagat cacgaatccg 2398201 gctacaatcg ggccgatcat tcctgcagag gaagacagaa tgcccataaa cccgttgaaa 2398261 aagtctcgtg tatccggctc tgttatttca aaggtcagca cgttaaacgc tagccaataa 2398321 aagccatagc caactccgag caccgcgccg attagcacga ggcggctggc cgccgtttct 2398381 ccggctaaaa gcacacttaa ataaaaggca gctaaaaaaa tgacgccgaa ccttaaaatg 2398441 aataccctgt ctattttttt ggctaaccgt ccagccaaat aaaaggttat cggctgcatt 2398501 gtcacaatgg ataaattata tatcgccaaa tcaataaatt tccctgactg cttccaaaga 2398561 tacacattaa caaatgtatt ggacagtgca attcccagcg agtaaagccc gccaatggtc 2398621 agcagaaaga gtaagccttt gtttacgtct acatcgccta tcactttttt tagtttgctc 2398681 attactgact cccctttact atcccttagt ctgtctcact caaaccgaga tatgtaaaaa 2398741 gaagacataa aaaaacaagg tcccataatg aggaccttgt ttgtgccatt attttgcttc 2398801 gctgtataga cgagccactt cgtcccagtt tacaacattc cagaaagctg aaatgtaatc 2398861 aggacggcgg ttttgatagt taaggtagta agcatgctcc caaacgtcaa gacctaagat 2398921 aggcgttttg ccttctgaaa gcggagaatc ttggtttggc gtgcttgtga tttcaagttt 2398981 accgttgttc acaacaagcc atgcccagcc agaaccgaag cgtccagctg ctgctgctgc 2399041 gaattgctct ttgaatttgt caaagcttcc aaatacactg ttaatctctt cagcaagcgc 2399101 gccagtcggt tcgcctccgc cgtttggaga taaaagtgtc cagaataatt tgtggttcgc 2399161 gtgtccgccg ccgttgttgc ggactgcagt gcggatgttt tcaggaacag aatcaagatc 2399221 tgcaacaagc tcttcaactg atttgttggc aagagcagtg tttccttcaa ccgctttgtt 2399281 taaatttgtc acgtatgtgt tgtggtgttt cgtatggtga atagtcatag tttccttgtc 2399341 gatatgcggt tctaaagcat cgtacgcata aggtaattct ggaagttcgt aagccatgat 2399401 aattcctcct tagtatatat gtactgaaat gccgcttcac agcgagcctt tcttcattca 2399461 atgtaacaaa agaatgcttt gtaatcaatg aaaaagctca cgatttggct catttcagcg 2399521 gacatatttc actttaaccg ataatctgcc ccattaaacc tgccgccagc atttcttata 2399581 ggaccgtcca taaaaagtaa ccgatcatca aaagctgtat gatgcccttt gcaataaccc 2399641 ctgttaaaaa accaatgagt gagccgaggc caattttaaa cgctgacttt aagtccttct 2399701 gatggacgat aagttctgcg caaacagccc cgataaacgg ccccaatatg atccctgcaa 2399761 ccggaatgac aaaaggcccg attaataaac cgatcgtgct tccccatatg gcagctttgc 2399821 ttcctccgaa cctttttact ccaagcagat tcgacacgta atctgctgcg aataatactg 2399881 cggcaaaaac tgcctcaaca agccagaaca tataagaata cggactgaat gaaaataaaa 2399941 atccgtacaa tacaaatccg gcaacaataa atactacgct aggaataaca ggatacacca 2400001 gcccgataaa ggcaatgata aaaaccgctg caatcaacag ccaatacaac atatccatag 2400061 cttccatcct cccattttac tctgtcttct tcatgtcttc cttgtattca cacgcatgca 2400121 acgatacaat aagcaacata tattagttta gctaggaagt gaagatagtg aatgtgtttc 2400181 agcttttcat taaaagtaca tactctcccc gtgatattgc aaaaacaaga tttcaaggaa 2400241 tcggaaaagc gattctttat gtatttttgc tctctgtcct gtttgcaatc cctaccgctt 2400301 attatgtaag tacagggacc gtaaaatcaa tgaacggctt taaaactgtt ttaaacaaag 2400361 atttccctga tttcacaatt tcaaacggca aacttcaaac ggatgagaaa aaagccacgg 2400421 aatctcaggc aaatggtttc gttatcgtgt tcgatccgac agactcctat ggcactgaac 2400481 aaattgaagc aaagcaaaac gcaatcggca tccttcagaa caaatttgtt ttggccattg 2400541 acggacaagc ccaagaaatg tcttactcaa tgatgccgtc agagttacag aaaaaagatg 2400601 tcattgcagg tttaaaccaa aataaagcga tgattgtaac tgttctctca gctcttattt 2400661 ttctcgtaac agcagcggga aaatttattg aagtatcgtt tttagcgctt atcgggttaa 2400721 tcattaagaa ttcgcagaaa aaacatttat cctatcatca gctctggaag ctttctgctt 2400781 attccatcac actttcaact gtattcttta caatcatgcg ggcactagaa gcaaccgtac 2400841 caagtgaatt tttgctgaac tggtttgtca attttgtcat cctgtttctc gttttaaaag 2400901 agattccgtc caaaaaagta attaataaaa gttaaattat atttattttt atcctttaag 2400961 tagagagtgt gaaagcattt gcattaactt tttacttaag ggatatttaa taaaatgtat 2401021 agagcttaaa cagatacatt tataaaaaaa gctctacaat tactcaagaa caagctctgg 2401081 acaataatat cagaagtagt aagatgtaac atgaaagaag ttcttaacag catttgacat 2401141 atgtttttaa caaaataaga ataatgttaa attttaacta atagactagt taaaatcata 2401201 tggcaaaata ttttgcatcc tttcacaaca tatttacata agatagttgc tatttaaaaa 2401261 gccaggtacc aatagggcac ctagctttca gaattaaatc atcaacaagt tagaattatc 2401321 ttctttcctt ctattctcat tattgaactg ttatcttttt tgtgggttta tgtatacaaa 2401381 tgcagctccc ttagctttcc ccttatatac tgataaacct actgcccaag gtgttcctgt 2401441 cggttttggt aatttactga agtaaaactt tttggttgga gttctacttg aaaagtaccc 2401501 tgaatattgc gggccaatgt ccccaccctc aactatagat acaccaaagc tcttataatt 2401561 tagtttaccg cattttccat ttgtttcggc gtaagcatca atagatgttg cactcttagt 2401621 atatgtataa gcatctgtaa taactcttat tttacaacca gaaataccac ttaccggttg 2401681 ccaaccactg cttgcagcct ctgctttttc tttaggtgca actaccaaag ttaacattag 2401741 tagcaaaatt aaaaacacag aaaattttcc ttgcttcatt ttgtagatcc tcctttaaac 2401801 tattacataa ttatcctaac agatccattg ttcattgtaa ataatggaat acgagtttta 2401861 tattataaaa gcctcttttt gatctaattt tgcactattt tctattttct atctgaagtt 2401921 aatgtttagt cgaagaaatc ctgtcaaaaa agcgcctgta taaaaaccga gcattcgcag 2401981 tctcttttct tttgtcatga atcgaaatgg acaagcatac tatggtataa aatttcgtat 2402041 gcgggaggaa aagcgatgaa gcgtctcacc ttagtatgca gcattgtttt tatacttttt 2402101 attctttttt atgaccttaa aattggaacc atacccattc aggacctccc tgtctatgaa 2402161 gcatcagcaa aaacggctgt acaagaaccg gcttataaaa cggtgaaggt aaagccgggt 2402221 gatacggtta tgtcgatagt cggatcagca ggttctccgg atgacattgt aaaggatttt 2402281 gaagcactga atccaaatgt gaaagctaac gccattcaag ccggaacagc gtataaattc 2402341 ccggtctacc cttaatttaa cgttaatttc ttgtcagttc ggcgaagaca ctgttacaat 2402401 gtaatttgta aaataaattc acataaacca tactagaatt gttatatcta gaagcggcaa 2402461 ctacaattaa ggagcgattg caagtgagtg aaatcacaca tcgtacaaaa acgcgtcccg 2402521 tcaaagtggg acctttaaca ataggcggca acaatgaagt tgtcatccaa agcatgacaa 2402581 caacaaaaac acatgatgta gaagcaacgg ttgcggaaat taaccgtttg gctgaagccg 2402641 gatgccaaat cgttcgggta gcatgtccgg atgaacgggc ggcaaacgcc attgcggata 2402701 ttaaaaagcg catttccatt cctctcgttg ttgacataca tttcgattat aaacttgcgt 2402761 tgaaagccat tgaaggcggc gcagataaaa tccgaatcaa ccccggcaat atcggccggc 2402821 gcgaaaaagt tgaagcggtt gttaaagcgg ccaaagacaa aggcattccg atcagaatcg 2402881 gagtaaacgc cggttcattg gaaaaacgga ttttagaaaa atacggttat ccgactgccg 2402941 atggaatggt agaaagcgca cttcatcaca ttaaaattct tgaggatctt gattttcacg 2403001 atattattgt cagcatgaag gcctctgacg tgaaccttgc aatcgaggct tatgaaaaag 2403061 cagcgaaagc gtttgactac ccgcttcacc tcgggatcac cgagtcagga acactgtttg 2403121 ccggcacagt aaagagcgca gcaggactcg gcgccatttt aagcaaaggc atcgggaaca 2403181 ccatgcgcat ttcactaagc gcagaccctg tagaagaggt aaaagtagca agggagcttc 2403241 tgaaatcttt cggcttagcc tccaatgctg ccacgctcat ctcatgcccg acttgcggcc 2403301 gtattgagat tgatctaatc agcattgcca atgaagtgga agagtatatt tctaagataa 2403361 aagcgccgat taaagttgct gttctcggct gcgctgtaaa cggacctggt gaagcgagag 2403421 aagctgatat cggaatcgcc ggcgcacgcg gtgaagggct gctgttccgg aaagggaaaa 2403481 ttgtccgtaa ggttccagag gaaacgatgg tagaagaact caaaaaagaa attgacattc 2403541 ttgctgagga acactacgca aaacttgaag ctgaaaaagc aaaattaaaa gaagaaacac 2403601 aaaaagcttg acgggaaccc gtcaagcttt tttgtgttag aaaaatggaa taataaatat 2403661 tccaagcact aatgaaacga caccgatacc cattgcccag gctccaaggc cttgagcacc 2403721 tcttcttctt gcgatatagc cgacaataat accagcagct cccaataaaa caggcagtac 2403781 aaacaatgaa atgatggaca aggctaaagc gatgtaccct attccccgtc cttcattgac 2403841 attgccgccg ctgcgatcat tgtcttggtc attgctgcgg tcagcagcac gataaggctc 2403901 tgcgatttca gcagctgttt cctcaaaaaa accgtcattg tcgcgggtaa tatttgtccc 2403961 ttcagatcca tgatcaacat agtaactgtt gttatcacgc ttttcgtaat cgtttgccac 2404021 cttcaattcc cccttctgtt ttattaaagg agcttttata gtttgatcca ttttgcctga 2404081 ttcatgtttg ctaaactttt ctgttaatgt caattgttta tgttacactt gaagggatga 2404141 aactgaagga gtgtgggcat gttacgctta ggaatagata ttgacggcac aatcacggct 2404201 caggatacat tcgtccctta tttgaaccgt tcgtttaatc tttccatttc attaaacgat 2404261 atgacggatt atgatttaac aaagctgtta aacattaccc aggaagaatt ttgggattgg 2404321 atgaatcaaa atgaagcgat catatataag gaagcattgc ttgcacagca tgcgaaacag 2404381 tctctcgatc ttctcaaaga ggagcacaag cttatttata ttacagcgag acggactcat 2404441 ttaactgata ttacttatga atggtttgac agacaaaaca ttcattatga ccacatcgaa 2404501 cttgttgggg gtcatcacaa agttgaagcg gtcaagaatc ataacatcga cctgtttttt 2404561 gaggatcatc acgggaacgc catgatgatt gcgaaagaag ccgggatacc ggtgattttg 2404621 ttcaattccc cttataatca gcttccgatt gattcaaaca tcatcagagt aaacaactgg 2404681 ctagaagccg ttcaatggat gaacaacaac aagcatcact taatacgcgt caataactga 2404741 aaaaggagcc caaaccgggc ccctttttca tatatacgca ttttacgcag tagtgttttc 2404801 ttggttttcc gctgtacaat cagggcatgt gccataaatc tcaaatttat gcccgctgac 2404861 ctgatagcca tccaaatcat cacaaagctt gtccatcgga catgattcaa tttcctttgt 2404921 tttgccgcag gcaagacaaa taaaatgatg gtggtgatgg gtgaatgaac acttaaatcg 2404981 gaagagcttt tcaccggaca gctcagttgt ttccaaaatc ccaagttctt catataaaga 2405041 aagatttctg tagattgtat caaagcttaa gcctggataa tcatcattca gtgcagacag 2405101 tacgttttta gcggtaagat atctgtctga atcagcaaaa agctgcagca tatcctcccg 2405161 tttgtttgta tatttatatc cgttttcttt taataggttc agcgcttctt ggacgttcat 2405221 gaagggtccc ccttttcgct ttgcttaaga acgtatcaca tgtatgaaaa agaaaatggc 2405281 agctgtctgt ccagcaagcc attttcttta ctgcagataa aattataccc ataaaatgaa 2405341 taaaagtaaa tgaaagccta gtggattgcg tttttgaatt ttccgcctct cgtttcatga 2405401 gtattcataa ttgttatgaa tgcattttga tcaacttcaa acacgatcga tttgagcttt 2405461 gtcacttcca gccttgtgac aaccgcgtaa attacgtctt tttcttcgtc cgtatacccg 2405521 cctttcccct tcagcttcgt tgtgccccga ccgagacggt gcaaaatcgc gtcggaaatc 2405581 tcatcatact gctcagacac aataatgaca gcttttgttt catcaagccc ttggatcacg 2405641 gcatcaatcg ttttcatcgc aatataataa gtcatgaatg agtacatcgc ttgctcagga 2405701 ccgaacacaa aaactgccca aatgaaaatg aacacattga tgaacataac gaactcacct 2405761 acagaaaacg ggagtttttt ggtcagcaaa ataccgagaa tttctgtacc atccattgaa 2405821 cctccatttc gaataacaag cccgacgcca aagccgagta aaagacctcc gaacacagta 2405881 gccaaaatag gctgggttgt aatggcttct acatggtgaa gtgaggattc aataacggca 2405941 agcccgacaa tccctataaa cgtagagact agaaaggtct taccgatata tttatatccg 2406001 aagatcataa aaggaatatt taatatgaca acgaaaaaag cgaaattcag aaaggggttt 2406061 gacataaaga ggtggtctaa aataagagat acaccgataa tcccgccatc aataaaatca 2406121 ttggggatta aaaataattc aatacttaca gccgcagatg cagctcctac cagaatcata 2406181 aagaccctga aaataaaatg ggtaaatgtt tctttcttat gttgttttgt tggggtcata 2406241 aaatctcctt tcctgcaata actattttaa atacattata aatctatttt accattaaac 2406301 actgacacat tttactgatt tgcccataca ttaagtctgg aggtggaatg accgatgatt 2406361 ttatttcaaa gaattatttt gcagcggctt aatcaggcta ctgctgatga tttgctgaag 2406421 tactcaaaac aatacggaat cagcttaaca agatcgcagg ccgttgaagt agcgaacctg 2406481 ttatacggga aaaatgtaaa catctttaat gagagtgaac gaatgcggct gctgaaacaa 2406541 gtagagacga ttacatcgaa agaaacagct caaacagtta atgaactatt caaacaattt 2406601 acaagctaaa aaatgggggt gttatccccc attttttatt gctgtaaaat cttttcaagc 2406661 aatgtatcat caaattgttt ttctttcagc atttcaatct caaaacggta tggcggtttt 2406721 ttgttctttt tatcttcacc gacgtatggt gtttcaagaa tttttggaat gtcttttaac 2406781 tgctcatggt gaacaacata ttgcagtgcg tcaaaaccta tttcaccaaa gccaatattt 2406841 tcatggcggt cttttctcgc acctttgaca tttttgctgt cattgatatg aagcacttta 2406901 atacggtcaa tgccaatgat tttatcgaac tcatttagca ctccgtcaaa gtcttcgaca 2406961 atgttatacc cggcatcatg tgtatggcac gtgtcaaagc acactgacag ctgctcattg 2407021 tgtgtaacgc cttcgataat ctgcgcaagc tcctcaaagc ttctgccgca ttctgatcct 2407081 tttccagcca ttgtttctaa tgcaatctgg acattttgat tcggatcaat cacttcattt 2407141 aagccttcaa taattttttt gatgccggct tcagctcctg cccctacgtg agcgccagga 2407201 tgaaggacaa tttgcttcgc tccgatggcc gctgtccgtt caatttctga acgaagaaaa 2407261 tcaacaccca gctcaaaagt ggacggattt gtcgtgttgc caatattaat aatataaggc 2407321 gcgtgtacga taatctcgtc aatgccgttt tcttgcatat gtgcccggcc tgcttctata 2407381 tttaagtctt caattttctt tcggcgcgta ttttgcggtg cgcctgtata gatcataaac 2407441 gtattcgccc cataagagac tgcttcctgg cttgcagcca gaagcatatg ttttccgctc 2407501 atagagacgt gtgagcctat tctcagcaac aggttcccct actttctttt cttagattgg 2407561 tttcttctct gttttttctt gattttctcc atctcatagc tcattttctt tttataccca 2407621 ggcttaacct tcttcggctt tttcacgaga cgatgagcaa tttcatccgc ttcattcggc 2407681 gtttttttac gttttttgcg gcgctgacgg tcatcgcctt ttttccattc gcccttttca 2407741 agctctaagt actcaaattc gatgcccatt ttttcaagtc ttactaatgc atcctcatca 2407801 gtaagctcat aaatggtcat cgcttgtcct gatgagccgg cacgagccgt tctgcccaca 2407861 cggtgaacat agaaatcgag atcatccggc agctcatagt tgataacatg gctgacacct 2407921 ttaatatcaa tacctcttgc ggcaaggtca gttgcaatga tatatgtgaa ttccaaatca 2407981 ttgatctgct tcatgacttt tttccgctca cgtggtgtta atccgccgtg cagcaagccg 2408041 attttcatgc ctttgccagt cagatactgg gcaatatggt cagccgtatt tttcgtgttg 2408101 gcaaacacaa tccccaggta tggattcaga tgcgacatga tgtcaaaaag gagcttgtcc 2408161 ttgtcacgat gtttcgaagg aatgaggata tgctcgattt tcgcagcagt cacctgtttt 2408221 ggctccacat gggcgtattt cggattttcc atgtatttct tcaagaatgg tttcagcttt 2408281 tccggtatgg tcgctgagaa cacaagcatt tgcagatcct caggcatgcg ggaaccgatg 2408341 taatctacat ctgcaaggaa tcccatgtcc agcattaaat ccgcttcatc aataacaaga 2408401 gattccgctt tatgaacact taacgcctgt tctttgatta agtcagcaat ccgtccaggt 2408461 gtaccgacaa caagatgcgg ctgtattttc aatttatcaa ttgatttttg tttatcagtg 2408521 cctccgataa aacatttcga gcgaatctga cttccttctt caccctgcgt gattttaagc 2408581 gcttcctgat aaatctggtt ggcaagctct cttgtcggag ccgtaatgac tacctgaacg 2408641 acatccttag caggatcgat tttgtttaat aaaggcagta aataagcgtg agtctttcca 2408701 gtacccgtct gagactggcc gatgacgctt tcttttttta acactgcagg aatcagcctt 2408761 ttctggatat cagtcggttc gtaaaaacca aggcgatgta ctgcatctat aataaatggt 2408821 ttcaattcat aaagttcaaa tttcgtttct ttcatttttc ccagctcctt aaagcggcac 2408881 attatgtgtc catcatcaca ttatacccga ttttgcttaa aaacaccacg tttgcaaggc 2408941 gtttgtttta ttcagttatg taaagcaaat accgcagccc atgcatattc taatagcaga 2409001 gagagctgaa aggaggtaca agtatgtttt caccgcagca gccaatgaga aattacccac 2409061 agcccggacc gccccgcccc atgccaaatc agcgaatgat gggcagaaga ccgcctaata 2409121 tgcgaggacc ttcatttgga gcacagcagc aaggttttca gcaagccgga caatttcttc 2409181 ctcaggcaaa tgccggagcg agaaatggtg caggtgcagg cggaggctta aaaggaatgc 2409241 tgtcaaggtt cctccccggc ggaggaggcg ctggcagcgc cggggttccc ggaattccag 2409301 gagcaggtgc agcagcgagc ggaggtgctg gcctgcaagg cattcaaaat attgccaatc 2409361 ctgcatcatt atccagtatg cttggaaatg tgcaaaaagt actcggcatg gcgcagcaag 2409421 tcacccctat gatccagcag tacggcccat tagtccgcaa tctgccagca atgatgaagc 2409481 tgtacagcca attaagtaaa agtgatgata ctgagacaga ggccaatgag gaaagtgaaa 2409541 aacaatccgt ttcagaagaa tcatcagaaa aagaaaaaga gactgaaaca aaaacctcag 2409601 atgggaacaa aaaatcaaaa ccaaaaagtt cttctctccc aaagaaatct aaaacaactg 2409661 acaataaaga acaagaatta aaaacatctg ccccgaagaa aaaggaagct gcctctcctg 2409721 ctccgaaaag aacatcaggc agttcaaaac cgagattata tatttaacat tctttgatat 2409781 cttaagtgag attggctata atgagatcag aagaatgcaa gaatagagcc gtttgattac 2409841 ggctttttat attgccttta ctcacttcag tattggagga caaccgaaaa tggacgtaat 2409901 taaaatttca ccgcgcggct attgctatgg tgttgttgat gctatggtca ttgccaaaaa 2409961 tgcgtcgcta gataaaagct tgccaagacc catctatata ctcgggatga ttgttcataa 2410021 taaacacgtc actgatgcgt ttgaagagga agggattttt acattggacg gctctaaccg 2410081 tctggacatc ttaaagcagg ttgacaaagg aactgtcatt ttcactgcgc acggtgtttc 2410141 tcccgaagtc agaagaatcg cagaagaaaa agggttagtc gcaattgatg ctacatgtcc 2410201 ggatgtgaca aaaactcata atctaatctt agagatgaaa gaaaaaggat atcacgtgat 2410261 ctatatcggc aaaaaagggc atccagagcc tgagggagcc gttggcgtag cgccggagat 2410321 cgttcactta gttgaaacag aagaagatgt aaagaacctt gatatccaat ctgagaagtt 2410381 aatcgtgacg aatcaaacaa caatgtctca atgggatgtt cacgacatta tggagcttgt 2410441 caaagaaaaa tatcctcatg tcgaatatca ccaagagatt tgcctcgcta ctcaagtgcg 2410501 gcaggaagct gtatcagagc aggcaaaaaa agcggactta acaatcgttg tcggagaccc 2410561 gaaaagcaac aattcaaata ggcttgctca agtgtcagag gaaatagccg ggacaaaagc 2410621 ataccggatc ggcgacttaa gcgaattgaa gctcgaatgg ctgaaaggcg ttaataccgt 2410681 tgcagttaca gcgggagctt caacaccgac gccgatcaca aaagaagtca ttcgcttttt 2410741 agagcagttt gatcacgaag atccatcaac ttggacaact gaacataata taccgctcaa 2410801 aaaaatactt ccaaaagtaa aagcaaaaaa ctgaggctgt aaaagcctca gtttttttat 2410861 agaaatgtaa atggatttgt atctgtttca gaaacaaaga tattcacgcc aaacttttta 2410921 tcattacaca ttgatgtaag ttttctcgtg acgccttctt tcatgatttt ttccgcgtaa 2410981 tggcccggat caaccacatt taggccaagc atcatcgcat catgggccac atggaagtat 2411041 aaatctcctg tgacgtaaac atcggctccc tttcgttttg catgatgaat atacttgttt 2411101 ccatctccgc caagaacagc tacttttttc accatgctgt cagcatcccc aaccattctg 2411161 acaccattga cgtcaagctt gtctttcaca aataaagcga attccttgag cgtcatctca 2411221 tttttaaggg ttccgacacg gccgagccct ttttcggcgg gagtctgttc gacaggatag 2411281 atatcgtaag cgacttcttc atatggatgg ctttttatca ttgcattgat aacagccttt 2411341 tcgacgcttt taggaaatac agtctcaagc cttacttcat gaacaagctc aagctctccc 2411401 acttcaccga taaaaggctt agctccgtcc aatggcttaa agctgccgat tccttcagat 2411461 gaaaacgcgc aatggctgta ttcaccgata tggccggccc ccgcatttcc gagcgcggct 2411521 ctgacctgct cttcatattc cttcggcacg taaactgcca gctttttcag aggatccgta 2411581 taagtaggtg ccagcacttc cgtctcactc agctctaatg cttcagcaag caaatcattc 2411641 acaccgccgt ccgcaacgtc taaatttgta tgagctgcat aaacagcaat atcatgcttc 2411701 aaacactttt caattaacct tccggcaggc tgatctgttg aaatatgctt tagcgaccgg 2411761 aaaattggtg gatggtgtgc aataatcaag tcaacctctt tttcaatcgc ttcatcgata 2411821 acgctctcta acacatcaag tgtaaccatc acatttttaa ttggtttgtt taaggtgccg 2411881 atttgcaggc cgattttatc tccttcaacc gcataggctt tcggggaaaa ttgttcaaac 2411941 agctggatga tctgctgccc atttacactt ttagccatga tcgattacct cctttaacag 2412001 ctccattcga tcggcgagct cctttaattt ttgtttgttt tgctctgtat ccgccgcttg 2412061 gctgatctgt tcataaatgc tttgagtgtg ctgaagctct tgtgtccact ttttcaaaaa 2412121 gacagcattt ttttcttttg ccaagaaagg gccaacgagc atcccggctg ataaagaaat 2412181 accgtcataa gccgcatccc tgtctcccgc ttctgccacc agcacctcat agcactttcc 2412241 gtcctcttca aggattacct catctatcag cgcatatctt tctttataaa gccactccct 2412301 gatatgaaca gcatgaatat tcggctgtaa aatgagccgt tccttccccg ttaatttgtc 2412361 tttgcccgct tctaaaatgt gagcgatcaa agccccgccc attccggcaa tcgtaatggc 2412421 atcagcttca ccttttttaa tcacttccag tccgtctccc tgccttacag aaatgtgcga 2412481 gtttaagcct gatttttcaa cctgccgctt tgcagacaaa aatgggccgt ctgttatttc 2412541 tccggcaatc gccccgctgg ctttatgatt cagcaccgca taacaaggaa ggtaggcgtg 2412601 gtcagagccg atatcggcca tcaccgctcc attcggtatg tactccgcta ctgtttgcaa 2412661 tcgtttagat aattttaatt cgttcacttg tcatcacaac ttttctcaat cattttttcc 2412721 tttactatca tataaaaaat cagcccggaa tccaagctga agcaaatgat tttgaaatta 2412781 tttcttttga tgcgggtctg cacgcagcag tcaaaaataa aaggctgtcg agaacatctc 2412841 ggcggcctgt gaatgtataa agagaaaaat agttctttta tttaattttt gacacccact 2412901 ctgccatatc atccagctta tcggccggaa caagaccgga aggcattcca ttaccgcctt 2412961 tttcgatctt tgttttaatt tcagcgacat ctttcttatc ccctacacct tttaagctag 2413021 gacccgaaac accttcataa ttttcaccgt ggcatgcgat gcagtttgcc ttgtaaattt 2413081 cttctggtga agcgtttgca tctttctttt cagcagattt gctttctcct ccgctcgcaa 2413141 tctcccgaga gtcatcaagt ccttttactg ataaaaagaa agttagacca attcctaaaa 2413201 cagcgatcag caaaaatgga ataagcgggt tccatttcat ttcccttccc cctttttgat 2413261 ccttccccct atgtaaacac ttctaattct aacttatttt tacaaaaagt aaatggattg 2413321 ctatacaaaa gttttttatt cacactttat acaaaattga atagaaacat gcctaaatct 2413381 ctaatatcct ttttattcta ttgtataatg tattgtatac gcttacaata gaaaatatgg 2413441 aattagattt tgaaattttt caccacaatg ttcatttgca aatgacatca tttttcagta 2413501 aaataaaggc atattatcca tatatctttt taaaaaaaga agaacggatc ttcaagaccc 2413561 gttccatctt attcaaggaa atctttcaaa cgtttacttc tgctaggatg tcttagtttc 2413621 cgcaacgctt tggcttcgat ttgtcgaata cgctctctcg ttactccaaa tactttgccg 2413681 acctcttcta atgttcttgt acggccgtca tcaagaccga atcgaagacg caatacattt 2413741 tcttcacgat cagttaacgt atcaagcaca tcttccagct gctctttcaa tagctcgtat 2413801 gcggcgtggt cagaaggtga agttgcttct tggtcttcaa tgaaatcacc aaggtgcgag 2413861 tcatcctctt caccgatcgg tgtttccaga gataccggct cttgagcaat ctttaagatt 2413921 tcgcgtactt tttcaggcgt taaatccata tcttccgcaa tttcttcagg tgttggttct 2413981 ctgcctaagt cttgcagtaa ttgacgctgc acacggatta atttattaat ggtttcaacc 2414041 atatgaacgg gaatccggat cgttctcgcc tgatcggcaa tggcgcgtgt aatcgcctgt 2414101 ctgatccacc acgtagcata cgtactgaat ttataacctt tgcgataatc aaatttttca 2414161 acggctttca tcaggcccat gtttccttcc tggatcagat caaggaacag cataccgcgt 2414221 ccgacatacc gttttgcgat actgacaaca agccgcaggt tcgcttcagc caatctgcgt 2414281 ttagattctt cgtcaccttc ttcaatcttt tgagcgtagg cgatttcttc ttttgcagaa 2414341 agaaggttaa cccgaccgat ttcctttaaa tacatacgaa ctgggtcatt gattttaacg 2414401 ccaggcggta cacttaggtc attaaggtca aattcttctt cggctttggc aagctgctga 2414461 atattaggat cttctgtttc ttcattctca ctaattaatt caacaccttg ttcacctaaa 2414521 aattcataat actcatccat ttggtctgat tcaatttcaa agctggacat acgctcagca 2414581 atttcttcat atgtcaaaac gccacgtttt ttaccagact ctgttaattg ctcttttact 2414641 tggtcgaatg ttaattctgt ctcgtgggtt tgtttatcag ccattatgga tccctccttc 2414701 caaagcttgc aacgaattct ataagcggta tgattcttat tcggtccatt caggcgtttt 2414761 ctatgtgaac tgcctttaac aatgtgcgaa taatgaaatg acaattcatg atgaggttaa 2414821 gcgatctatt tgctcctccg caaggaatca ttgccaataa atgctcctca tcagttctcc 2414881 agttatttta aagatcggtt caatgtaacg atttcttgag ccaaagaagc agctcttaaa 2414941 aaatcttttt gcctttctgc ttcggctctt tccgcctctt tttcttttat cattgaccaa 2415001 tttctttgat tcaacacttt ttttacataa tctgataact cggcttcgct aagctcttga 2415061 ttaacctgaa gcattaatat atcggacaag agctggctta tatgatcatc cgtcaccctg 2415121 gccatcagat gctgaggcgt cagctcggct ccctcttcat aaaaagcata aagataagcg 2415181 gctaatgccc ggtgctcatc aatattaaat tgaaacccta cccggtcaat cacttttttg 2415241 atgacgctcc gatctcgaag catgtgagcg agtaacagcc tttctgcatt ttcatacgcc 2415301 ggacgcaaac gtttttgcct tgcttttgtc gtcagatgcg ctcgccgcgt tttagtttca 2415361 ccgctattgt cagcaggttt gttttgcttg ctgaaaacag acagctgctc agttaaagac 2415421 tcctgtgaaa gcgaaaactc tgaagcaagc tgctttacat agacttcctg ctctagagac 2415481 cctgaaagcg tgctgatttc tttcagtacg tctttaatgt aagctaggcg gtcgccttca 2415541 tcggacaggt tctttccttt tcggaaatat tgcattttga acgccattac ggtgacactt 2415601 gcgtcaataa tgtcgttttt aaatttttcc ccgccgaatt ttttgatgta atcatcaggg 2415661 tccaatccgt caggaatcat tgcaactctg actttgcagc cttttttttg cagaagctcc 2415721 gaagctttta aggtggcttc ataaccggct ttatcagagt catagcaaag aatgatttct 2415781 tcgacgtttc ttctcaggat cttgacatga tcatctgtaa gagacgttcc catcgtggct 2415841 atgctttcct ttacatccga gcttacggcc gatatgacat cagcaaaccc ttcaaataag 2415901 actgctcttt cctgctttct gatatgaagg cgggccttat aaaaattgta aagcagtttg 2415961 cttttatgaa agagcggggt ttcaggactg ttcatatact taggctgctg gctgccaaga 2416021 gccctgcctg agaaagcaac aacagccccg tgatgatcat ggatcggaaa catgacacgg 2416081 tttctgaagc ggtcgaaata tccgcttccg tcttcgcgtc tgatcaggag acccgctttt 2416141 tccatttgcg cctcactaaa tcccctcttt acaaggaatt tcgtgataaa gtcccaagaa 2416201 tcaagagcat agccaatctg aaattcatta atcagctctt tcgtaaagcc cctagaaagc 2416261 agataatcca gtgcctcttg accttctttt gtatttatta acaaatgatg gtaaaatttc 2416321 ttcaggagct catgtgcctc agccattttt tgttctccag aagactctgg ccgggctccg 2416381 gaatggactg ttatatcatc tggaaaatca atttggtatt tgtcagcaag gtgagaaacc 2416441 gactcggcaa aagaatagcc ttccatctgc cttaaaaaag agaaaacatt gccgcccgct 2416501 ccgcagccaa agcaatgaaa aatctgtttg tcgggcgata cggaaaacga aggtgtgctt 2416561 tctccatgaa aaggacagag tccaaagtag tttcggcctt gcttctttaa ttgaacataa 2416621 tcacctatga cttcaacgat atctgccgac ttttgcacct gatccacaat ttcatctggt 2416681 atccgatttc ccatcttata acactccgtc gtacattatt cgatgcttta gtgcaaaatc 2416741 ccttcatcgt tcgacaggat tttttgcagc agtgtaataa atcgttctcg atcttcttta 2416801 ttcaattttt taggcccttt ggcatatacg ccttttcttc tttgtttgcc ggaaaaatga 2416861 cggccctcta gggcaaaatc aatcgtgtct tccttgtaaa gacgacctct ttccgacata 2416921 acagagacat ttctgttcaa cagcagagat gctaatccga tgtcctgcgt cacaacaata 2416981 tctcccggtt tcacgtgatt tgcgatatat aaatcagcag cttctttatg aggatcaaca 2417041 tacttccatt tttcttcatt gcttctggaa agctgataat gttcaaatga agcgacaaaa 2417101 agaacttgaa cttcatactc ggatgctgtt tgtaaaattt catcttttac cggacaagca 2417161 tcagcatcga caaaaatcgt cttttcttgt tcattaagaa gagtaattct ccatccctcc 2417221 attaaactcc tgcataaaag caagcaaaat cgcacatcct ttattattgt ggatgtatat 2417281 gaatttgtcg aaaaatttcc gggagaaatt cttgacatct tacccataat agtttattcg 2417341 tatcacacga tccttaaacc taaaattaat cattttatca caatttttta ttataataca 2417401 aacttcacaa agatgctatt gtttttcatt attccctttt ggcacagcca aaaacccagg 2417461 atagagcgtc ctgagttata tgttttttgt tttgagatga tggataatat ttgctgtttc 2417521 ctcaaccgct ttatttgaaa catcaacaac ctggcagccg atccgatcca caatcttttc 2417581 gaaatactcg agttcctctt tgattctgtt gatatttgca taaatcgctt tatcattaag 2417641 cccgagtgat tttaaacgtt cttttctgat atgattcagt ttatcagggc taatctttaa 2417701 accgatgcat tttttcggat caacgttaaa gagttcttcc ggcggatcaa cctccggtac 2417761 aatcggaaca ttggcaacct tcaggcgttt gtgtgcgaga tattgagaca gcggtgtttt 2417821 agacgttctt gacacgccga tcaaaacgat atcagctttt aaaatccctc ttggatcacg 2417881 tccatcatcg tatttaactg caaactcgat ggcctccact tttttgaaat aatcttcatc 2417941 aagctggcgc acccgccccg gttcgtattt cgctgttaaa ccgtaggctg tttccatttt 2418001 atcaatcaac gggccgataa tatcataata taaaacattt gctttttccg cttcggctat 2418061 caaatattct ctgatttccg gcaccacgag tgtaaaacag ataatgccgc cgtctgcctt 2418121 tgcaagtgaa atcacttcat tgatagtgcc tatatcttca acataaggaa ttcttcttac 2418181 atgagtatca tccgccgatc cgttaaattg gctgagtgct gcttttacta ccaattcagc 2418241 cgtttcaccg acggaatccg atacaacata gatgatgcgg ttattcatat tatccccccg 2418301 ttagtttgca atcttatagg atttcatttt cagataaact gacaagtatt ttggtcatat 2418361 ttgtttttgt cactctgccg atcacttcaa agcctttatc ggtgtctttg atgacaggca 2418421 gtgcatcaat ttgtttttct attaagtgct ttgcaatgtc catcacataa tcctcgcgtc 2418481 tgcacaccgt aatgttcggc atccttgtca tgatgatgtg aacagggacc gatgtaagct 2418541 cctgctggcc aatgctcgct ctgagcaagt cttttcgtga aagcaccccg actaaaacag 2418601 catcgcggtc caccacaaac agagtaccta catcttctaa aaacatggtg caaatcgcat 2418661 cgtacacaga aacgttttcg tgaatcacta cggggataga ttgaaagtct ttcacctgaa 2418721 gctttttgag tttatccgcc aaaagctgtg tgccggtttt tcccgtatag aaataaccga 2418781 ctctcgggcg cgcctcgagg aatcctgaca tggtgagtat ggctaaatcc gggcgcaatg 2418841 tcgccctggt taggttcagc ttttctgcaa tatgctcccc tgtaatcggc ccgttttctt 2418901 ttacaatctg caaaatatgt tcttgccgtt tatttagttc gatcgtactc accacctttt 2418961 cacttcatag ctatgtaaag aaataacaat ccatattata acgtaaatat cttgtaatca 2419021 aacaaaaaac ttataaatgg ggaaaagacg attaccgatc acacagcaac cgccttttct 2419081 ctctttattt tacaataagg gcattcatat tcgcaaagga cttgatctca tccgccaagc 2419141 ttaccatttg cgctaaacga tttgccttta atgactcatt atccgctata accattgtat 2419201 gatcgaagta agcatcgatc ggttctttta aggctgcaag tgaagcaagc gccgcctcat 2419261 aatctttttt gctgaagttt tcctgcagat tttgcttcgc tgtttggtag gcatcaaaca 2419321 gttttgcttc gtattcattt tcaaacagat caggctgaat gtctccgcgg actccttttt 2419381 tgctgataga gatcactcgg cctaacgctt cggctgtttc cttaaagcca ggtgcaccaa 2419441 gcttttgctc cagtacttgt gctttatgca gcgcagagta cggctcaagc tcagagcttt 2419501 ccagcacggc gtcaatgaca tcatgtctga tttgttcagc attcaagaca tatttcaagc 2419561 gctgagtgaa gaaatccagc agttcatttt ctttatcggt ttgaacgaaa gtaagcagct 2419621 cttcaaatga aattccccag ttgcggtcaa gaagaatcgc aacaataccg cttgcttggc 2419681 ggcgcagtcc gtaagggtcc tgggaaccgg tcggaattac gccgatagag aagaatgaag 2419741 cgattgtgtc aagcttatcc gccattgcta caacagctcc ggtgaaagta gaaggcgttt 2419801 ctccgcccgc tgatctaggc atataatgtt cattaactgc cgcagccaca gcttcatctt 2419861 cgccaagcat tctcgcatac ttttcgccca taattccttg aagttcaggg aattcatata 2419921 tcatatgcgt cacaaggtcg aatttagaaa tttcagcagc ccgcttcaca tgttttaatg 2419981 tatcttcatc agcctgaaga cgaacggcaa gtttctctgc gattgatgtg actctcctaa 2420041 ccttatcagc aagagaacca agctcttcat ggaaaacgat attttcaagc ttcttcacat 2420101 ttgcatcaat gtttagtttc tgatcttctt tgtagaagaa tgaagcatca gataaacgtg 2420161 cgcgcagcac tttttcattg cctcgggcca cattttcaat cgcgtggctg ttgccgtttc 2420221 ggactgtgat aaagtgaggc agcaggtcac cgtttttgtc tttgacaggg aagtagcgct 2420281 gatgctcttt cattgtcgtg acaagcactt cttcaggaat tgacagaaac tcggattcaa 2420341 atgaaccgta aagagctgtc gggtattcta ctaaatgatt cacttcatca agaaggtctt 2420401 cgtcaactgg aatgctccaa ttgttttcag cagccattgt ttccagctga gattgaatca 2420461 tttgctttcg gacgctagga tcagcaataa catgctgtcc tttgagctgc tcttcataag 2420521 ctgaaggtga ttcaattgac acttcatgtc cgaggaaacg gtgtccctgt gttgtccgtc 2420581 cagactcaac gtttgtgatc gaaaatggaa tgacatcctg tccaaataat gcgacaatcc 2420641 atttgatcgg tcggatataa cgcaaatctt catttcccca gcgcatgttt ttcgggaaat 2420701 gcaagcttgt aattaaaccg ctcaattctg gcagaagcga cttcgtttct tggccggctt 2420761 ggaatttttg cacgaataca tactctatgc cttttacttc tttgatgtac aggtcttcca 2420821 catttgcgcc ttggcctttt gaaaagccga ttgccgcttt tgtccagttc ccgtccgcat 2420881 caagggcaat ttttttcgca ggcccttttg cttcttcttt tatatcatcc tgcttttctg 2420941 cgacatcctt aacgaacaca gcaagacgtc tcggtgtatt gaagagtttc acttcaccgt 2421001 gagtaatatt tttttcttta agccagcctg tcagcttgtc gccaagctga accatgcttt 2421061 cattcaaaaa gcgcgccggc atttcctcta atccgatctc taaaagtaaa tcctgtttac 2421121 tcatgagaag aaccctcccc tttaagcatt gggaacccta gtttttctcg ttcctcatag 2421181 taggtttttg ctacttttct agctaaattc cgcactcttg cgatatagcc cgtccgctcg 2421241 gtaacagaga tcgcaccttt ggcatcaagc aggttgaaag tgtgcgagca tttcagcaca 2421301 tagtcatatg ctggatgaac aagtccgttg tccatttgct tgatcgcttc tttttcatat 2421361 gtgctgaaca attggaacag catatcgacg tctgatgttt caaacgtata aacagaatgc 2421421 tcatattcag ccatcatgaa taaatctttt actgtaaacc ctgacgtcca ttccaagtca 2421481 aacacgtttt ctttatcctg gatataagac gcgagacgct caattccata cgtaatctct 2421541 acagaaacgg gtttacactc taatcccccg acctgctgga aatacgtaaa ttgtgttatt 2421601 tccattccgt caagccaaac ttcccagcct agacccgcgc agcctaaaga cggattctcc 2421661 cagttgtctt caacaaagcg aatatcgtgc tcaagcggat caattccaag agcacgcaag 2421721 gaatccaaat acagctcttg aatgttatca ggtgacggtt taataatgac ctggaactga 2421781 tgatgctgat acagtctgtt cgggttctcc ccgtagcggc cgtctgccgg acgtctggaa 2421841 ggctctacat aagccacttt ccacggctca ggaccgatac tgcgcaaaaa tgtatacggg 2421901 ctcatcgtgc cggctccttt ttctacatcg taagcctgca taagcacaca gccctgactg 2421961 gaccaatgct tttgcaaggt tagaatcatg tcttgaatat tcatttcaag cacctccact 2422021 tttctttcat aagttgactg cggcagcaac caaaaaactc ccgtctctat gcttgccagc 2422081 cgcaaacata gggacgagag ttctcccgcg gttccaccct agttgctgag aacaaaatcc 2422141 cagcctcttt tttaaaattg ctcaagaatg cctttcgttg cgtgctcatc cttagcttac 2422201 accgccctaa ggtcgctttc atgaggtaaa cgcaagtact tctttctctc actgcaacat 2422261 attttataat aaatgatcat ataaaaagat ggaccaaatg tcaacttttg ttttcaccca 2422321 taagatgttt catgctttcc atttgatcta aaaagcgctt tgattttaaa tacaatcccg 2422381 aatattcttc gtaatataaa tcaatcactt gctttaattc agcttttgtt tcctctttta 2422441 aggacacatt gccgagtctc gacagatcaa aatagtaaaa gagccttaac agccttgccg 2422501 tttgcggttt aatcggtatc ctgtaaggat ctttttcaaa acagcggtgg catataaaac 2422561 cattatcacg aacagagaaa tgaaaggttc cgtcttggct tttacaatgt acacaatgat 2422621 tcagctcagg atacaggccc atgacaccga gcatcttcat ttgaacaatg aaggtgataa 2422681 catccggatc tgttccttca ttcaactgtt ttaatgattc taatatgaat tcaaataaat 2422741 aaggatttgg ctttttttct tctgtgcctc tgtcgactaa ctcagcaaca taggcagcat 2422801 atgctgttaa aaacaagtct tccctgatgc ctctcatgct gaggatcatt tccccctgct 2422861 gaagcgttcc gaggcccgat gttttttgca ttaagaaaga accatacaaa aagggctggc 2422921 tgactgctga taaacggctg ttcggttttt tggcgcctcg tgccataaca cctatttttc 2422981 cgtgttctct tgtcagtaat gttacgattt tattcgtctc tccgtaatca tttgtgcgaa 2423041 gaacgatccc ttcacatttt gtcagcattt ccgcaccttc ctcaagcagg agcggccaag 2423101 aggtttataa aattggataa tcaaatcggg ctagctcatc ttctagttct tcgggtcttt 2423161 ccatgttctc tttttccagt tctttaaaaa gaagatacgt atcaacattt cctgtttgag 2423221 aaaatacgtt ccaggtaaaa ttcaacacaa gaaacccacc tttctgtagt taaactagct 2423281 tacctaaact ccaaattctt acctttatct tgaccagatg tcctccattt catgttaaac 2423341 aaaatttgct aatgtatccc tgttcctgtg agataatgac acacacggga agagattaat 2423401 attcgtcctc tttaaagcca aaatcgcgaa gctgggacat tttattacgc cagtctttct 2423461 gcactttcac ccacaattca aggtagacac gggagcccaa cagtgcttca atatccgctc 2423521 tcgctctttt tccaacctct tttagaaggc ttcctttttt accgatcacg atgcctttct 2423581 gggaatcccg ctcgaccaca atcgttgccg ctacgtgcac agaaccgttg tcctgccctt 2423641 tgatggattc gatggccacc gcaatgctgt gcgggatttc ttctctcgtc aaatgcagca 2423701 ccttttccct gattaattca gaaatgataa atcgttcagg gtggtcagtt acctggtcac 2423761 tcggatagaa ttgcggccct tccggcaaat acgcttcgat ctgcgcgagc aaggtttcga 2423821 tgttatttcc ttctaaagca gaaatcggaa caatttcctt aaaaggataa cgtttgcggt 2423881 attcgtcaat tagcagaagc aattggtcgg gatgaatttt atcaattttg tttacgatta 2423941 agaatacagg cgtagacatc gtctgcaatt tctcaatgat gaattcgtcg cccttcccgt 2424001 agccttcctc agcattgatc ataaacaaga tcaaatcgac ttcttttaat gtattttgcg 2424061 ccactttcat cataaagtcc ccaagtttat gcttaggttt atgaatccct ggtgtgtcaa 2424121 taaaaatggt ttgtgatgtg cctgtcgtca gtactccttg caccttgttt ctcgtcgttt 2424181 ggggcttatc gctcatgatc gcgatttttt gtccaatgac tctgttcaaa aatgtagatt 2424241 ttcctacgtt tggtcttcca ataatggata caaatcctga tttaaagctt tcgttcgtca 2424301 tgtaaatcct ccgatgaaaa tgcgcctggc aataattctt ccacagtcat ttcttttatt 2424361 tgtccttgta aattagtcag tacgacaata acgtcttttg tgcaaagctc agaaatcacc 2424421 tgtcggcagg ctccgcacgg agatactggt ccaggggtgt cagccgcaac ggccagcatc 2424481 tgaaactctg tatccccttc agaaacagct ttaaataaag cggtacgctc ggcgcaattg 2424541 cacatgctgt atgccgcgtt ctcaatattg cagcctctgt acacttttcc atccttggta 2424601 agaagagcgg ctcctacttg gaatttggaa tacggcgcat atgccatatc acgcgctttt 2424661 aaagcttctg ttattaattc ttgtctgttc atgtgtacat tcctctctta cctataatgg 2424721 taccgctatc actttatatt ttacataatc gcgcgctttt tttcacgccc atttctaaaa 2424781 atgtaaaata aatgtaagaa ttttcagcca ttacagcttt ggcaaaaaaa taagtaaacc 2424841 aatgatacac gaaatcacgg caaaaacgca aacagccccg gcggcagcgt ccttggccgc 2424901 tttagcaaga gggtgatgtt tgtcagttat taaatcaacc gtatgttcaa tggctgtatt 2424961 taaaagttca agcgaaaaca taccacctat caaaaggaat ataatcatcc actcaataat 2425021 gctgagctct acaaggaagc cgcaaatgag aacagcgcag gcggctgcgg catgaaattg 2425081 gaaattccgc tccgtccgcg ctgtttccca tatgccccgg cctgcatgca cgaagctttt 2425141 gaagaatcga ttcagctcat ttctatgatc ttttgagtcc ataagcgtcc agcaattcct 2425201 tttgcttagt aaacatctcc tcttcttcct ctttcgtcat atggtcatat cctaaaaggt 2425261 gcagaaatcc gtgtacagct agaaatccga gctctctttt aaaagaatga ttatactcct 2425321 ctgcctgctc tcttgtgcga tcggcactga tgataatatc acctaaaacc ggaggcattt 2425381 cggcgcccac gatttcgatc tcgccttctc cctcttcttc aagagcaaat gagatgacat 2425441 ctgtcggagc atcctttccc cggtattctt tgttaatctg atgtatgtca tcattggaaa 2425501 caatcgtgac agaaacttca gcctgatcct gaacgccttc acgctcagcg gcaaattgaa 2425561 gcagattttc tacttctttg agcatctctt ctgagacgct tcccgtttca tcaacgatat 2425621 caatcagtaa actcatctat ttcaccttct tagtagcctc cggatattca atccgggagt 2425681 ggaaaattcc ttttaatgtt gcacagagcg tttttgcgat tgtatccagc tctttaaatg 2425741 tcaaatcgca ttcactgaac tgtccgtcct gaagcttatc ggatataata ccccggacaa 2425801 gcttttcaat tcgttcagga tttggattgt gcatggatct gacggccgct tcaacactgt 2425861 cggccactga tataattgcg gcttcctttg actgcggctt cggtcccgga taacggaact 2425921 cttcctctgt aatctggtcg cctttttcct tcgctttata gtaaaaaaac tttaaaagcg 2425981 aggttccatg atgctgctca gcaatatcga caagctcttt cggaaattta tagcttctca 2426041 gcatattcgc accgtctgtc gtatgcgaga taataatatt tttgctcaac tgaggtgaca 2426101 gcttgtcatg cggattgtca atattcattt ggttttcaat aaaatattgc gggcgctttg 2426161 tttttccgag atcgtgataa tatgcgccga ctcttgcaag caaaccatta gccccaaccg 2426221 cttcacaggc tgcctctgat aaattggcaa ccattacact gtgatgatat gtacctggtg 2426281 tttccgtcag tattttgcgc aatagcggat ggttaggatt agacagctcg agcagcctca 2426341 tggtggataa aatgccaaag cccgtctcaa aaaacggcat cagaccgatg atcaatacag 2426401 atgaagcaaa ccccgacaca acccccatga gcattaacgt gccgatttca agacccgaca 2426461 gcgcagtgtt ctggatcaat aataaggata gaacgacaac catattaata aacgccacga 2426521 aaagtccggt ctgcaaaatc tttgatcttg cattgtgttt tcctaaaaat aatacacctg 2426581 aaatgccgct gatcaaataa taaatcccta tgacataatt gaatgttcct gtcacaccct 2426641 gattaaacat catacttccg caaatcgcaa gaatgatact tcccaaaatg gcaatgcgtt 2426701 cattcatcag cagtttgatt aagatggcgc cggccgcaat ggggaccaga tagccgatat 2426761 tattatactc catcttctga aacaaactga caacctccat gatcacaagc aaaagtgttg 2426821 tgattatgga gaataacaga atggattggt ttttaaactt cagattttgt ttctgttttt 2426881 caaaataata tacaagtgtt gcaatgaaaa gtccgatcat aatcaatagc ccgctgatcg 2426941 gtttaaagag atttgagtta tttaataacc cggtcagctc aagtttcctg tacacttccc 2427001 gatcaatgag gtcattttct tccacgagca cttgcccctg tttgatttga acctgctgga 2427061 cattatctga ggcttcctgc cgttttgcct ctgttgcttt cggatcgaag acgtaattcg 2427121 gaataatagc aaaacgcccg atttctgtcg cggctcccaa gtatttagac ggaatagaat 2427181 tgctctttag ctctttttct accttatcct ttgcatcaga tagtttatcc gaagggattt 2427241 cactgctcat gaccgtattt accgcggtaa tgaccgtatc tctgacaaaa gaaaagtctt 2427301 cactgtctgc tttcagcaat gtcttgatgg aatcctccga tatagaatca ttcacatctg 2427361 atgtcaattt gtcctttaca gatttgacca ttgatttttc cgatggtgat ttactgcctt 2427421 cttccgatga ttttttcact tcactaatac tgtcgaatat tgatgacaca aggtcaatcc 2427481 gattgtctgt atattctttt tttaatgtat attgatcttc aaccgcgtcc tcagcggctt 2427541 gctttttttc ctctgtggct ttttgatctt ctacggttgc cggagcgtaa atggtcttgt 2427601 cgctgactga aaacaggtct aaatcaagtg tttccggctt aacatgtaca aagagcaaag 2427661 caaacataat ggcagccagc agaagataca gcagtacatg catggagcgg gcatttttaa 2427721 aactgctcca tttttttgag ctgcttttgg tcttagcctt ctttttcaac acaagaacct 2427781 cctcttgaaa catcaagccc ataagcaatc ataaaaatga cccgataacg cgcgatcggg 2427841 tcattcagca ttaattttgc ttatcgtatg cttcaataat tttcgcaaca agcggatgtc 2427901 tgaccacgtc tgtctggtct agctcaatca tagaaatgcc gtctattcct ttcagcatct 2427961 ccttcgctac tgcaagtccc gatttgacgc ctttcggcag atcaatttgg ctaacgtcac 2428021 ctgtaatgat cattttagag ccaaaaccca gtctcgtcaa aaacattttc atttgagcag 2428081 gcgtggtatt ctgtgcttca tcaagtataa cataagcatc atcgagcgtc cgtcccctca 2428141 tatatgcgag cggagcaatt tcaatgatgc ctctttccat cagacgttct gtatgatctg 2428201 ccccaagcac atcatggaga gcgtcataca gcgggcgcaa ataaggatct actttttctt 2428261 ttaggtcacc tgggagaaaa ccaaggcttt caccggcttc cacggcaggt cttgttaaaa 2428321 tgattttttt gatatgtccg ttttttaaag catggactgc ttttacgaca gccaggtacg 2428381 ttttcccggt tcccgccgga ccaatgccga atacaaggtc attccgcttc atagcggcca 2428441 cgtattcccg ctgtcccatt gtttttacac ggattgattt gccttttgcg ttttttgtaa 2428501 tttcttcttc atacatgctt tcaaagtatt caagttcatt cttctttgcc attttgatgg 2428561 cgtaaatcac atcacgttca gagatctcta tccccttgcg aattaaagcg aggagcgatc 2428621 ccagcagcct gtctgcaatc tgaaacgatt catcatcgcc tgaaacataa atcgtctcgc 2428681 cgcgcgtaat gatatttaaa ttcagatctt tctccatcaa tttcaaaaaa gaatcttggt 2428741 tcccgaagag tgaaagcgcc tcgtccgggt ttttcagttt ttgattcatc gcaagtaaat 2428801 gttctgtcat tcttcagtct ccctgacaat aggtgtggtt tgaacgatat cttctataac 2428861 ttggtagaga ataatcaact ttactttacc attctcaaca gtctggtgca aaactttttc 2428921 acttttcacc tcgccgtttt cgcctatttt atcctctaca tcctgtttac ccaatttaat 2428981 gccttcttga actgcttctt cttttgtata ttttcgcaaa gcctcttcac tttctctcgt 2429041 ttgctctttg acataggata cagggagctt aaatccgaga aaatgaagcg aatgcttttc 2429101 ttgttctgtt tttggatgct tcaattcctc ttttttaaac gtcatccccc agatcgggat 2429161 tgccaaagaa ccaaaagaaa gcttgtgctt tgtccttact ttgcccgtat agacgttaaa 2429221 taatgtttca agcgggactg tcacttctga tctataccag gtttctccat aaatttctgc 2429281 ttttgaggcg acttcctgct gatggtcttc gctgccgatc agtcccgaaa caagcagctg 2429341 tcccttttca acatgatcgt gtatggcggc catgggctgt cctttttgca caaacattct 2429401 cgtaatggtt gctttctttt tggcgacaat attgcgcggg ctaacatatt tttctttttc 2429461 gggctcattt ttctccacaa ctttcatatg aatggtcgtc cccttcagat caactccgac 2429521 ccaagtgata ttgtctattc cattggttaa tgatttctgt attttttcgg gcgacatcat 2429581 taaaaactgc agacggccct ttttgacgcc gatttcatta agatgctgcc tcatttgatg 2429641 ttctgtttca ggcttagcgc ctgtcacatc aattttccac accatattgg acagcaaaaa 2429701 caaaagaatg aaaaaaatcg caaaaccgat cgtaaaccct atattcagct ttgatttcag 2429761 caacaggaag ggaaatccct tccgattgat aaatcgggct ttacatttaa atttacttct 2429821 tacccgccga aaggcatgta catcctgaag ctgtatatat aacgatacgg cttctttctt 2429881 ttttttgaca tgaaagaccg gaatcccctg tcttgtgcat tcattaagga gccgctcaat 2429941 ccctcttccc gtcaattcaa gctggacctt acccgaaaaa aaagacagcc atttattttt 2430001 cacaacattt ccccctcggc tttatgactc aacatatcga acgacatcaa tcgtaccctc 2430061 caaaagtatc tcttccggaa gaatcgcctt gatgacaaaa tttttaccag atatgatgca 2430121 ctggccctgc ttcagcatca gccgcacttc attctcactg aaaagcaaaa ggcctctgtg 2430181 gttttctatg tagatatgaa gtctgccaac cattgtaatc ctcggcagat ccatcataac 2430241 gtccggggga atttccaatg ctcttgtcag ccaagctttc atacgattct ttctttgccc 2430301 catacaaaaa gaaccccctt tcatctcata tgtatgattt gaaaggaggt tctaacactt 2430361 taatttttac gggccgggcg catcgtacgg tgaggttttt tcgcccgtgg aggtccgaac 2430421 acctctccta gaacgatccc ctgtacgacg gtgtctttat tcacctgaag cattttttgt 2430481 tttgtgtata ctgttttttg tttggcagca gcaagatctc gttccagccc tttcaggttt 2430541 cttgctgttt ccctgcgtct ttcttccgct tcccgtcttg cctgttccat acggttaggg 2430601 ataggtgcag gggcatcttc ttttgactgc ttcttttgag gagaagcaga ttgcacgtgt 2430661 tgaggttttt ttcttttttg gctgttttgc ttttcttctt tgctcttttt gccgaaaatc 2430721 gcagaaatga ttccgatgat cgctgcaata ataagcggat tggtcagtaa atcttccatc 2430781 agcgttctcc cttcttagag agattatgat ttgcggtctt catccgaagg gtctttcgtc 2430841 agcttgccga atgaatcacg catttctgtg tcagcatcga tgttcttgat attcatgtaa 2430901 tccatgacgc caatattccc ttcacgcaaa gcttctgcca tcgcaagcgg cacttccgcc 2430961 tcggcttcta ctactttcgc gcgcatttct tctacgcggg cacgcatttc ctgttcttga 2431021 gcgacagcca tcgcacgtcg ttcttccgct tttgcctgcg cgatgttttt atcagcctcg 2431081 gcctgatcgg tttgtaaaat tgccccgatg tttttgccga tatctacatc tgcaatatca 2431141 attgagagaa tttcaaacgc agttcctgag tccaatcctt ttccaaggac tgtctgagaa 2431201 atcatgtcag ggttttcaag cactttttta tgattatcag atgaaccgat tgtagaaacg 2431261 attccctcac ctacacgagc tacaatggtt tcttcccctg ctcccccgac gaggcgctcg 2431321 atattcgctc ttactgtgat tctcgctttc gctttcactt caatcccgtc cattgcgacg 2431381 ccggcaatga acggtgtttc aatcacctta ggattaacgc tcatttgaac agcttccaac 2431441 acgtcccggc ctgcaagatc aatggcagca cagcgctcga atgtgagttc aatgttagct 2431501 cgctgagcgg cgataagcgc gttgacgact ctgtcaacat tacctccagc cagatagtgg 2431561 ctttcaagct ggtttgttcc aacattaagt cccgctttat gcgctttaat cagcgggtta 2431621 acaacccgat tcggaatgac gcggcgaagc ctcatcccaa ctagagtgaa aatgctgatt 2431681 ttcactccgg ctgccaaagc tgaaatccaa agcattacag gcacaaatgt aaaaaatact 2431741 gccaaaacaa tgatcgctac tgcgacaatt gccagaatca taagtgttga cggatccata 2431801 taacttctcc tcgtttctat ttaaatttct ctcacgacaa tgcgtgagcc ttctactttt 2431861 atcactttta cttttttatc tttttctgta aacgatccct ccgatacaac gtcaaggcgt 2431921 tcatcatcaa taatcacggt accggaagga cgcagcggtg taaaggttat acccactttt 2431981 cccattaagt ccgtgcgcgt ttgatttgaa acgtagccgc tctccgtgtt tgtagaatca 2432041 tttaatatca atttcttaaa gaatttcata cgctttccca acacccttgt cagtaaaata 2432101 aaagctgtaa tcgaaacagc tgaggcgatc aagagagaaa ccgccatgac agtgaagctc 2432161 cccgcggcta aaaacaggct cgcaataatc gctcccaagc ccagtaatcc aatgattcct 2432221 ccgggaagaa aaatctcaag cagaatgaga atcacccctg ctataaagag gagaaccgtc 2432281 tcatacccgg caaggccggc tgcaagatgc ccgtaaaaga acagcaataa cgcaatgagt 2432341 ccagccgttc cagggaggcc gacacccggg gaaaaaagct ctaccgtcag acctaaaaaa 2432401 gcgattgtca gcagaatagg gacaatgacc ggattcgtca gccatcttgc cgtcttttcc 2432461 gcaaagctct cctttgcata gctgatctgc gccttttcga acccaagctt ctttacgagc 2432521 gtggacaaat tgtcagcagt gccttctgaa tagcctacct caatcgcctt gtctgcgtta 2432581 agtgtcagca gatctccctt aggcgcgcca acttccttgg catctatatc tgggtcagcc 2432641 attgcgagcg catattttgg atcgcggtta tttttcactg cggcatcttc catctctgcc 2432701 agccaaagtg attgagcttt ttggtcagcg gcattgcctt ggccatcaac aatcgcggcg 2432761 gctcccattt ttccgccagg cgccatataa atgtgatctg cttgaagtgc aatatatgca 2432821 ccagcagaca acgcgcgttt gttgacatat gcagttacgg ggatctcgct ttcggttatc 2432881 aaatcggcca tatcaatagc agatttgacc aatccccccg gggtattgat atcaagaata 2432941 atatggtctg catgtgcatc ctttgcgtct tgtaacgaac gggacaaaaa cgaggcgaga 2433001 ccctgttcga catttttttc aaccgggatc acataaacag tttgtttttc tgcttttgcg 2433061 ttcagctgta cgcctaataa agaaagtaaa aatataccca aaagagcagc acggaatcct 2433121 ttgatttgaa gcaagggcgg tgtatccctc cttcctttta taataagtgc cttctcttca 2433181 tacgtaacaa atgtatcaaa ggtttcattt ttttatgtat aaaaaaagac atctctctta 2433241 gaaagatgtc cttttctttg ccatttaaga cagttgactg ctcacaagct tattaattaa 2433301 acttccgtca gctttacctt ttactttagg cataattgcc cccatcactt tgcccatgtc 2433361 cgcttttgag ctcgcaccga cctccgcgat ggtttcattt acgattgtac gcagctcttc 2433421 ttctgacagc tgctcaggta aataaacttc taaaatgtcc agctcttttt gaactttatc 2433481 tactaaatct aaacgattag cgtttgaaaa ttcctggagg gagtctttac gttgcttaag 2433541 ttcacgagaa aggacagtga gttcctcatc ctcggtcaaa ctgtctttct taagcttaat 2433601 tgcttcattt tgaagtgaag ccttaaccat tcgaacgaca gtcagtttgt ctttctcacg 2433661 gtttttcata tacagcttca tatcctggtt gagacgctca agaagactca taaatccacc 2433721 ctcttttaga atttgcgttt tctagcagct tcagactttt tcttgcgctt tacgctaggt 2433781 ttttcataaa attcacgctt tcttgcttct tgcaaagtac ctgtctttga tacactgcgt 2433841 ttgaagcgac gaagagcatc ttcaagcgat tcgttttttc taacgaccgt ttttgacatt 2433901 ctctttccct ccctccgaat acaccaatcg actaccttta agttacacat ataaacatgt 2433961 actttgacat tataatataa gccatcagtc aggtcaacta agtgagttca cttttccgtc 2434021 atgagtgcga ctgcctgtct atataatgaa agaaaggggt tggtgaatag gatgttaatt 2434081 ctgattagct ttactgctct tatattattc tttctcgcag gcatgaacat gcttcgaaag 2434141 ggcttaattt caatggcgta ctcaaaaatt gaagaacgtt tgcttttatt tacagaccat 2434201 ccgttaaaag cgtttcttat cagtattgta tttacgggga tacttcagag cagctcagcc 2434261 tttatggtca ttgtcatcgg ctttgtaagt gcgggcgttc tttcttttaa gcggacgatc 2434321 ccgatgattc tggggacaaa tgttggctct acttttacaa ctgaatttat tgctatcaaa 2434381 atggatattg tgatttgggt tcttttaata ggaggtttat tgttttttct gactggcagg 2434441 tatcctttga aacagctggg aacaagcttc cttggactgg gcatcatctt cttttgcatc 2434501 agcggattca gccatcttgc cgggccgctg acaaagctga aaacgggcgc cgacgttcta 2434561 taccatgtta acgattcaaa ctggtccgct ttgctcatcg gcatggtgtt aactgccatc 2434621 attcactcca gttctgtctg tatcggcatt ttgatgagtt ttatgaatga agggattatc 2434681 ggactgacac aggcgatgag cgtcgtactc ggatcaaata tcgggacatg cattacagct 2434741 gtcatggctg ctgtatccgg cggatatgcg gcgaaacaga cagcatatgc ccatgtggta 2434801 tttaacgtgc taggggtggc tctagtattg ccttttctga ccgcagcgac cggctttgta 2434861 gagcagttat cacctgatcc cgcacaaaag atcgcgcatt tcagcctttt atttaatgtg 2434921 gtgacagctc ttttatttct tccgcttaca aacttgtttt accgattgat tcaccttctt 2434981 atcccggcta aataaaaaaa tcggtacatt ttaatgcacc gattttttag gttaagaaga 2435041 caaacgcatg tgttcagtta tttcatcctc aaccacacgg acaaactgtc cttcgttgta 2435101 aggataacct gcttttagga ttttgacttt tacgattttg ccgatcatat cttccgtacc 2435161 tttgaaaaca accttcatat aattgtctgt gtaaccgaca aacatatttt cttcttctgt 2435221 ttccttaaac gcttcctcag ggataatctc aagcacttca ttttcatact gagaagcgta 2435281 ttcttttgca agctggtcag aaagagcaat caggcggtgc acacgttcgt ttttcacgtt 2435341 ttcatccact tggtcttcca ttcgtgcagc tggtgttcct gtacgcttac tgtaagggaa 2435401 aacatgcagc tcagagaatt tatgttcttt aataaagtta taggtttcca taaattcttc 2435461 ttctgtttct ccagggaacc cgacgatgac atcagaagta acagctaagc ctggcagtgc 2435521 ttttttcaat ttatttaaac ggtctgcaaa gaattccatt gtatatttgc gtctcatccg 2435581 tttaagcact gtgtttgatc cggattggat aggaatatgc aaatgattca ctatcttatc 2435641 tgagcggtct aagacctcga tcacttcgtc agtgatttgg ctggcttcga ttgaagaaat 2435701 tctgatccgt ttcacgcctt ccacacgggt gtctaattcg ctcaaaagct tcgcgaagtt 2435761 gtaatctttc atatcttcgc cgtagccgcc tgtatgaata cccgtaagaa caatttcctt 2435821 atatccggca tcgacaagct gctgcgcttg tttaatgact tcttcagggt cgcgggagcg 2435881 gagcaggcct ctcgcccacg gaatgataca gaatgtgcag aaattattgc agccctcctg 2435941 tattttcaat gacgctcttg tgcggtccgt gaaagcaggc acatcaagct cttcatatac 2436001 tcttgctttc atgatgttgc tgacgccatt aatcggctgg cgttcttctc ggtattggtc 2436061 aatgtagcca agcatttttt cacggtcctg tgttccgact acaatgtcga caccggggat 2436121 cgccataatc tcagcaggtg aggtttgcgc gtagcagcct gtgacacaga tgacaccgtc 2436181 aggattttga cgaatggcgc gtctgatcac ttggcggctt tttttatctc ccgtatttgt 2436241 aaccgtacat gtattaatga catatacatc agctgtttgt tcaaagtctc ttctttcata 2436301 gcccgcttct ttgaaaagct gccagattgc ttctgtttca taatggttga ctttacagcc 2436361 aagcgtatgg aaagcaacag ttgccattac tgatcacctc ttaataactc tgtttgataa 2436421 gaaatcgcac tcaacgcgta tagcggagcg gtttctgtcc ttaaaattct cggtccaagg 2436481 ccgcacgtca caccgtcttg ctctgtgagc cgttcaacct ccgcttctgt taaaccgcct 2436541 tcgggaccaa atacgatcaa tagagatgat cctttcggaa ggctgcttac aatcgcgctg 2436601 aatgcgctta tttccccttg cttcgatgac tcctcgtatg caacgacaca tttatcgaaa 2436661 tcctgcatcc tttgaagaag ctgctgaaaa gaatggacat ccatcactcg cggcacttcg 2436721 ttacggtacg attgctcagc cgcttccttc gcaattttcg tccatctttc ccgctttttc 2436781 tttgcctttt tgtcatccag cttgacaaca gaacgcgcgg cttggaaagg aataaaggca 2436841 tgagctccga gctcagtccc cttttggata atccattcaa gcttatctcc tttcggaagg 2436901 ccgctcgcaa tatagacctt tatcggaagc tctctgtttt cattcgtcca ttctatcaca 2436961 aggcaggaca ctttatcttt ggaaacagat tgaagttcac attttgcctc gaagccgtct 2437021 tgagagcagc agataatctg atctccctca ttcattctca tcacgttcac aatatgatga 2437081 acttcttcgc cggtaatcga aaaagtcggc gcttcctcta tttgctgctt cgtgagctcg 2437141 ataaaatatc gttgcatacg ctgtgacacc tactaactgt tattttttcg caataatgct 2437201 gacccaatct tccattgaaa ggatttctac aatggtaaag ccagcttgtt ccagtgcttc 2437261 ttttacttct tgttttttat gaccgatgat tcctgacgta ataaagtgac cgccttcttt 2437321 taacaggctg tacgcttgtg aagtaaagcg aagaatgact tcagccaaaa tgttggccac 2437381 aatcacatca tgttcccctt caatcccgtc taacaaattg ttttgcttca cttgagcaat 2437441 atcgctgact ttgttcagct tgagattgag gcgtgcactt tctacagcca cgggatcaag 2437501 atcgtaggca tgaaccgatt cagcctcaag cattgcagcc gcaatactta aaattcccga 2437561 accagtgccg acatcaatca ccttatcacc cttttgcaca aagcgttcaa gcgcctgaat 2437621 gcagagtacg gttgtcggat gtgtccctgt gccgaaagcc attcccgggt ccatttcaat 2437681 aatcagttca tcagtatgga ccggcgtata ttcctcccac gtcggcacaa ttgtaaactt 2437741 ttcagaaatt ttcacaggat gataatactt tttccaggca gtcgcccact cttcttcatt 2437801 tacttcagaa atagtgatgt ggtttctgcc caaatcaata ttgtaaagaa ggagattatt 2437861 aatcgtttct ttgatgccgt ctacagtttc gcccagaaaa ctgttaaccg gcagatatgc 2437921 tttgacaatg acaccctcat ctgggtaatc attggggtcg agctggtaga tttccccgta 2437981 cacattctca cgttctttaa ttaaatcaag cgggtcctct atcacaaccc cacttgcacc 2438041 agcttcatgc aatatatttg agataggttc gaccgcttca tgtgttgtgt gaatgcttaa 2438101 ttcggaccat ttcaaaacta ccaactcctc atccaataat taatcgcctt taaacgcgcg 2438161 ttttaccttg tcaaagaaac tcatttcctg ttcgtcaggc aggtttccgc tgacttcggc 2438221 aaattcgcgg ataatgtctt tttgtttatc agtcagattt gtcggcgtaa cgacgcggac 2438281 gacgatatgc tggtcaccct gtccatagcc tctgacattt tgaacgcctt tgcctcttaa 2438341 tctgaatttc gttcctgttt gtgtaccggc cggaattttc aatttcactt ttccatgcag 2438401 cgtcggcact tctacctcat ctccaagagc agcctgagca aacgttaacg gcatttcaca 2438461 gtaaatatca tcgccgtcac gctcgaagaa ctcgtgtgcg cgtacatgga acacgacaaa 2438521 taaatccccg gcagggccgc cgtttattcc tggttcaccc tgtcccgaga gacgaagctg 2438581 ctgcccgtca tctacaccgg ctggaattgt cacattgatt ttcttgcgtt ttttgatttt 2438641 tcctttgccg ccgcagtccg cacatttgtt tttaatgatt ttgcctgtac cttcacagtg 2438701 gtggcagacc cgtctgttaa cgacttttcc aaacggtgta ttttgctcca cgtttaactg 2438761 gccggagcct ccgcagtggg agcatgtttc tggatttgtt ccaggtttcg cacctgagcc 2438821 tttacatgtt tcgcacgttt cctcgcgggg aatttcgatg gttgtttctt taccgaaagc 2438881 cgcatcctca aacgacaggg tcatcgtata ctgtaaatca gcaccctggc gcggagcgtt 2438941 tggatctctt cgtcttgtgc ctccgccgaa tatacttgag aaaatatcat cgaaaccaaa 2439001 accgccgaaa tcgccgccgc caaaacctcc gccgccgaag ccttggttag ggtcagtgtg 2439061 accaaattga tcgtaatgcg cacgtttttg gtcatctgac agcgtttcgt atgcttcttt 2439121 tacctcttta aatttttcat ctgatccggc ttctttgtta atatcaggat gatatttttt 2439181 tgacagcttc cgataagctt ttttaatttc atcctttgaa gcgctcttac ttactcccag 2439241 cacttcatag taatcacgct tactcatctc gcttcactct cccgaatttc tcacataaat 2439301 tagattgtat cattttgaat tatgattttt caattccttt tatcccgggc aagaaaaaaa 2439361 gtcaaagcca agagatgcct gactttgact ttctaatcat tgaatcagat tatgaaatgt 2439421 gttcttttcg gtcagctccg gaagcggggc tgacactaaa aagaacttat tttttgtttt 2439481 ggtcgtcgtt tacttcttcg tattcagcgt cgacaacgtt gtcatccgct ttgccttcag 2439541 cgtttgctcc gccttgagct tgctgtgctt tagcagcttc ttcataaagc ttcatagaaa 2439601 gctcttgaac gattgtttga agctcatctt ttttcgcttt gatctcttca aattcgtttt 2439661 tctcaatcgc tgcttttaaa gcgtctttgg catcgttggc ttttttcact tgttcttcgt 2439721 ccactttgcc ttcaagatct tttaatgttt tctcagtttg gaaaacaagc tgatctgctt 2439781 cgttgcggac ttcgatttct tcttttttct tcgcatcagc gtcagcattt tcttccgctt 2439841 cttttaccat gcgttcgatc tcttcatctg agagacctga agaagatttg attgtaatgt 2439901 tttgttcttt tcctgtgcct aagtcttttg ctcttacgtt tacgataccg tttttgtcaa 2439961 tatcgaaaga aacttcgatt tgaggcacgc cgcgcggtgc tggcgggata tcagtaagct 2440021 ggaagcggcc gagtgttttg ttgtcggcag acattgggcg ctcaccttga agaacatgga 2440081 tatcaacagc tgtttggtta tcagcagcag ttgagaacac ttgagatttg cttgttggga 2440141 tcgtcgtgtt gcggtcgatc agttttgtaa acacaccgcc cattgtttcg ataccgagag 2440201 aaagcggtgt aacgtcaaga agaacaacat cttttacgtc acctgtgata acgccgccct 2440261 gaatcgcagc accaagcgct acaacttcat ccgggtttac gcctttatgc gcttcttttc 2440321 cagtttcttt tttgattgct tcttgtacgg cagggatacg agttgatccg ccgacaagga 2440381 tgactttgtc gatttcgctt gcagaaagtc ctgcatcttg aagcgcttga cggacaggac 2440441 ccattgtgcg ctctactaaa tgagaagaaa gctcttcgaa tttagcgcga gttaatgtaa 2440501 gttcaaggtg aagcggtcct gcttctccag ctgtgataaa cggtaaagaa atttgcgtag 2440561 aagatacgcc ggaaagatct tttttcgctt tttcagctgc gtctttcaaa cgctgaagcg 2440621 ccattttgtc ttttgacaaa tcaatgccgt tttctttttt gaattcagac accagatgat 2440681 cgatgataac ttggtcaaaa tcgtccccac ccagacggtt gtcgccggca gttgaacgaa 2440741 cttcgaatac accgtcgcca agctcaagga tggaaacgtc gaatgtaccg ccgccaaggt 2440801 cgtatactag gatcgtttga tcttcatctg ttttatcaag tccgtatgca agcgctgctg 2440861 cagtcggctc gttgatgata cgttctactt caagacctgc aattttacca gcgtcttttg 2440921 ttgcttgacg ctcagcatcg ttaaagtatg caggaactgt gataactgct tttgatactg 2440981 tttcgccaag atagctttca gcgtatgatt taaggtgttg aaggatgata gcagacactt 2441041 cttgtggagt gtaatccttt ccttcaattt caactttata atcagtaccc atatgacgtt 2441101 tgatagacat aattgtgtta gggtttgtaa tagattggcg tttagccact tcccctactt 2441161 gacgttcgcc gtttttaaat gcaacaactg atggcgttgt gcggtttcct tcagcgttag 2441221 caataacttt aggctcgccg ccttcaagca ctgccacaca tgagtttgtt gttcctaagt 2441281 cgattccgat aactttactc acttgaataa cctcctgcta tgtaattatt gattcacttt 2441341 gaccatggaa gggcgaatga cgcgatcctt cagcttatag cctttttgca tttcctcaac 2441401 aacaatgttg gagccgtagt tttcgtcttc agcctgcata acagcttggt gcagattagg 2441461 atcaaattcc tgccctacag cttcgatggc ttcgacgcct tcttttttca aggcttctac 2441521 gagctgacgg tggaccattt ccattccctg gagcaaactt ttcgtctgtt cattgtcggc 2441581 ttcaacctga agcgctcgtt caaaactgtc aagagccggc agcaaatcag tcacgatatt 2441641 ttgagaacgg tatttttggg acgcttccat ctctaaacgg ctgcgtcgtt tatagttttc 2441701 aaagtctgct tgaacacgca aaagtttgtt ttctttttcc tcaagcaaac cttgcaattc 2441761 gttaatttgg ttttgaagaa gttcgctttc atttgtttct tcctgctgtt catcagcggc 2441821 agcttgttct tcaatgattt cttgctcttc tgtttcgttt tgttcaacgg tttgtttttc 2441881 ttctgacatt gtgttcacct ccctcaaagt gtaaggagaa ggacaggtgc tgcccttcga 2441941 taaaatttgc caaaattccc ttattcatca tacagacttg ttaatgcttt tgacaagtcc 2442001 gaagtcacat gctgaagcag gctgacaacc ctggaataat tcatgcgggt cgggccgata 2442061 atcgcaattg agccgatctg cttctggtct acggaataag aagccgtaat cagactgcaa 2442121 ttttccatct cttcatagtc gttttctttt ccgattttaa tcgaaattcc cgtgtgcggg 2442181 gattgaacca gctttaaaac atcctgttct ttctcaatta atgaaagcag cgaccgaact 2442241 cgggtgatat catggaactc aggctggttc agcatattga ttttcccgcc aaaaaacaac 2442301 ttttcaacgt gatttgtgga atgaaaggtt gaacgaagcg cgtcgagtat attgtcatag 2442361 tttttaatgt gctgtcttag gtacatgaca acttctttaa atatgcgctc attcagttca 2442421 tccattggaa cgccgcttaa acggtcgttc agtatattta ccagtttttc aatatcagac 2442481 agatccattt tggtcggaaa gttaatcgtt ttgttttcca catgccccgt attggtaacg 2442541 agaatcgcta ccgccatatc aggctgaatc ggaatgattt gaatctgttt aaggtaattc 2442601 tcactcaact tcggcccgag tacgatggat gtgtaattcg tcagatcgga caaaatttgc 2442661 gctgattttt gaactgtctt ctccagctcg aaaattttct ctttgaagat cgagtggatt 2442721 tggtccaggt cgcttttcgt caatttgacg ggtgacagca aatggtcaac atagtaccga 2442781 tacccttttt ctgacggaac acgtcctgag gatgaatggg ttttttcaat aaagcccaat 2442841 tcctccaagt cagccatctc gtttcttatt gttgcagagc taaatgtgat ttcatctttt 2442901 ttcgaaagag ttcttgatcc caccggctgt gccgatttaa taaaatcgtt gattataacc 2442961 tgaaggatca gcagctgacg atttgttaac atcatcatca cctctgttag cactctcaat 2443021 aagcgagtgc taattctata acaaaagtat caaaccacaa gaaaaatgtc aattataact 2443081 cacccaaaaa agcgccaaaa acttcattgc ctaataattt cccttgatga gtcaaataaa 2443141 cggcagactc cgaattgtga atcagccctt tttcagcgag gtcttttaac acgcttggga 2443201 aaagtccatc cagggaacgg ccgtattttt ctgcgaatcg ttttttgctg acaccggctg 2443261 tttttctcaa acctaaaaac atttcttcct caatctgttc ttctgttgtc acttcatgtg 2443321 tatctctgta cggaaaaccc ttttcagcta tcaggtcaat gtaatgctta acaggtccga 2443381 cgttcactgt tcgtgtgccg ccaatatatc cgtgagcgcc agctccgaaa ccgaaatatt 2443441 gttcgttgct ccaatacgtt agattgtgct tagattccat gcctgcctta gcaaagttgc 2443501 tgatttcata ttgatgaatg ccgtgagctt ccatcttgct catcactatt tcatacattt 2443561 cagcttcctg ctcctgcggc ggaagatgaa gccgcccttt ttgcatcaaa ttataaaata 2443621 ccgttttcgg ttctacaata agggagtaaa cggaataatg ctcagcgtcc aatgataaag 2443681 cagtgtttat ggaatgttcc agatgcttga gggtttgccc cggaagcccg aacatgagat 2443741 caagactgat attctcaaaa ccgatttccc gcgctctttc aaaagaggtg aatacatctt 2443801 tttgcttgtg cactcggccg attttttcta acagatcgtc ttcgaacgtt tgcacaccaa 2443861 agctaaggcg atttacgcct gcttctttta atatttttaa tttctctgcg gacaaatcgt 2443921 ccggattcgc ttcaaccgca aattccgata agtcgcttga gggctttagc acgcggttga 2443981 tcatatccat cagcttttta agctgttcct cagacaggga ggtcggcgtg cctcctccga 2444041 taaagattgt tttgagatca ggctgcccgg tttttgctat tgtatttatc atttcctgtt 2444101 cgagtgcgtt taaatactcg tcgactggct gactttgaat aaaatattta ttgaaatcgc 2444161 agtagtggca aatatgctca caaaatggga tatggatata agctgatttc aacggattca 2444221 ccttctttac agaaagaagc cgcagtacaa gactgcggcg gcttctattg ttttttcgga 2444281 ctgtcgtcca ttttcagaac tgccataaat gcttcttgcg gcacttcaac tgagccgacc 2444341 tgcttcatac ggcgctttcc ttctttttgt ttttcaagaa gtttccgttt acgcgagatg 2444401 tcccctccgt aacatttagc caatacgttt ttacgcattg cttttatggt ggagcgggcc 2444461 acgattttct ggccgattgc ggcttgtacc ggaacttcaa actgctggcg cggaatgagt 2444521 tctttcagtt tttcaacgat cacttttccc cgttcatatg cgtaatcacg atgcacgata 2444581 aaggaaaggg catcgatttt ttcaccattc agcataatgt ccattttcac aagcttggac 2444641 ggtttgtagc cgatcagttc ataatcaaag gacgcatagc ctttagtgct tgatttcagc 2444701 tgatcaaaaa actcatatac gatttccgct aatggcatat cataaatgat gctgacacgg 2444761 tttgcgtcta aatactgcat atcaatgaaa ttgccgcgtt ttccttggca aagctccatt 2444821 acagcgccga catagtcatt cggcaccatc atcgtcgctt ttacgtatgg ctcctcaacc 2444881 ctttcgatct tttgaggatc cggcatgttg gacgggttgt cgacaacgac cttttcgccg 2444941 tctgtcatat acacgtcata gataacgctt ggcgctgtcg taatcaggtc gatgttgaac 2445001 tcacgctcaa ttcgctcctg aatgatctcc atgtgaagca tgcctaaaaa tccgcagcgg 2445061 aacccgaatc caagcgcttg cgaagtttcc gcttcatatt gaagggagga atcattcagc 2445121 tcaagctttt caagagcttc ccttaaatca ttatacttcg ctgtatcaat cggatacaaa 2445181 ccacagtaca ccatcgggtt tagcttgcgg tatcccggca gcgcttcttc tgcaggattg 2445241 gcagcgctcg ttattgtatc accgacacgt gtgtcaccaa catttttgat tgaggcagtc 2445301 aggaagccta catcaccgac cgtcagttca tttgtcggag ttgctttcgg cgtgaacacg 2445361 cccacctctg ttacttcgaa ttctttgccg gttgccatca ttttgatttt ttgtcccggc 2445421 tttaccgttc cttcaacgac tctgatataa gccacgacac cgcggtaggc gtcataaagc 2445481 gagtcgaaga tcagcgcttt gagcggcgcc tccggatctc cggtcggagc tggcaccttt 2445541 tctacgattt gttctaaaat ctcctcaatc ccgataccgg cttttgctga agcaagcacg 2445601 gcttctgatg cgtcaaggcc gataacgtct tctacctctt ggcgcacacg ttcgggctcg 2445661 gcgctcggaa ggtcgatttt attgatgacc ggaaggattt caagatcgtt gtcaagcgct 2445721 aagtagacat tggcgagcgt ctgcgcttca atcccctggg ctgcatccac gacaagaatc 2445781 gctccctcgc aggcagcaag gcttcgggat acttcatacg tgaagtcgac gtgtcccggc 2445841 gtatcgatta gatgaaagat atattcttct ccgtcttttg ctttatattt aagctgaaca 2445901 gagtttaatt taatggttat gccccgctca cgttcaagat ccatagaatc gagcaattgt 2445961 tctttcattt ctcgttgagt gattgccgac gttttttcta aaatacgatc cgctaaggtc 2446021 gattttccgt ggtcaatatg ggcaatgata gagaaattcc gtattctcga ttgcctctct 2446081 aaacgctttt ctttatctgt cacaatctat cactcctact attaaacgca aaatacacta 2446141 gcttagatta tatcaatagg attgtaaaga ttcaatgtaa aacaagaaag agaaaagttc 2446201 cctatcatat ctgggttgct tttctctttc acgtacttat tgattcatat cccgtatcca 2446261 ttcatacatt gactgggcag tattggttac ggtgtccgaa agcgcttttc cggcttttga 2446321 aaacatattg aatgtctcca ccttttccag ctctttttgt ttttctacta aatcttttgc 2446381 cgtgactgtt tctcctagga ttgaggcttc tttttcatta tcttttccgt cggtgagcgt 2446441 aaacgccccc ttcagtgaag ggtcatgata gcctttcata ctcagcatcc cgtggtttgc 2446501 ctgctgcatg ccgaacagaa cgcctaaaaa catgatcgtg acaagcagta agcactttcc 2446561 aaagtatgca atcaaatcaa ccacctattt cttattgttt tttcgtctcc ccgctcgctg 2446621 cgttgacctt ttcagcatcc cagtacattt cgctgaatac gtccgcggcc gcgttagccg 2446681 cacgctgcag ctcttcgaga ttattatcca ctccgccaaa ctcgagcaaa agcgctctat 2446741 cggttaaatc ctgattgtaa acaccattat cgcctggcga gcctttggaa aagacacctg 2446801 tgctaagtcc ggggtatttt ttctccatca gtttatgaag ctcactcgca attttatagt 2446861 tttcttcgaa gtttttgctt tttttcccga cgacaaaggc taccctggca tagcttttcc 2446921 ctttaatcgt tgcggttgtg tcttttttgc gccgagagtc tctgtggatg tcaatgatat 2446981 attgcagatt tttgtttgaa gcgagggcgt ctttcacgac cggccttgat tcatcatagg 2447041 acctggcata gtttaagcct tttttattca attttgactg tatatcggtt ttattcactg 2447101 tggctccgat tccctgggat tcaagcgctt gtccgaacat atctcctaca agcgtgacat 2447161 tggctttaga atggcgcgcc atgtcaggat cggtctcgcc ttttaataga gggagatatg 2447221 attccgtatt gtgcgtgtga tagataaaca cgaccttttt atcacctgtt gtttgtttcg 2447281 gcggatcttt ttgcgcatta tctgattgcg tttgctgttt ttcaatctct gccaaattcg 2447341 cttctctttc ttcctccatc accttagacg gcggcggcga ttccgcaggc atattcgtat 2447401 aatccgttcc ttgtccagct aacaaaatct cggtatcaaa ttgtgcaaat cctggcagct 2447461 cccgaccgag aaagctccgc ggatcttcga ggttaatgct cgtcgccagc tttaaagaaa 2447521 gacgagaaag atgaaatgag ctgtctgttt gagagaggtc agaagcgaaa taatggtttt 2447581 ccatctgcag caaatgtgca aatacgtcac ccggcaattc ttcagcaatc ccataaaaag 2447641 agtcagacga cggcctaagt tccggccgga gagacgtcag cacaccggat agaacaaaaa 2447701 tcacgataag gcttacgata aatagaaaga tggcttttac cgctttccct ccatttaccg 2447761 caacaacaat ctgtctgttt ctgcgtttat ttctcattga atccctccag cgcttgtcta 2447821 gtaattactc tatgaacaag ctagaggaag tagaactgtt tagtgattgt aggagccttt 2447881 gttttcttgt gacacttttt catgaagcgc tgtgtttaat ccgttcgcta aaacatttgc 2447941 catatcgtcg ataaatgaat cgacttcctt cggtgtaacc attaagttgt gccctaaagg 2448001 cgaaagcacc tcgtgaatga gctgccgttt ttcatcttct tgaagggttc cgacaatacc 2448061 taggaacgat tggcgctgct tttgatcggg aagatcgtct tcagtgagca ctttcttttt 2448121 cccaaacgtc atgcctgccg gaacaagcga tcttgatggc ctgttatcct tcatttctct 2448181 gccaaaatgt tttaatatgt agtccaccgt gtcgctggca attgtcacgg catcaactac 2448241 tgtcggaaca ccgatagcaa tcaccggaac accaagcgtg tctttgctta aatcttttcg 2448301 tttattcccc actccagacc ccgggtgaat gcctgtatcc gatatttgaa tggttgtgtt 2448361 gaccctttcc accgcccgcg ccgccaacgc atcaatggcg atgacaaaat caggcttcga 2448421 ttgctcaatc acacctttaa taatgtcact tgtttcgatt cctgttatcc ccattacacc 2448481 cggtgcaaaa gcactgacag gcctgtaacc ctcctgtacg ttttccggct gaagcttaaa 2448541 caagtgcctt gttaccaaca gattttctac tgccatcggt ccaagcgcat caggtgtcac 2448601 gttccagttg ccgagcccaa cgatcaaaca gctcgcatct tttgagatat taaggttttc 2448661 aagaaaagct gagaattcct ccgcaaagac agcagagacc ttctcctgca tttccgaatc 2448721 attctccctg attccctgtg cttcaagcgt taaatagcgc ccttcttttt ttcccgaaag 2448781 ctctgcgcct tcctttgtaa catcaactgt gcggatttta atgccgccgt gatcacgctc 2448841 tttttcaata aagcctttaa tttcttttgt cggcacagcc tgctgattgg ccattgcttc 2448901 cttcgtttcc actgccaaat cggtccgtat caaatactga ttcacatcca gctcactctt 2448961 tttcatacag gggcctcctt cacattaagt acctatattg ttgccatttg ctgaataaat 2449021 catgctaaaa agagaacctt caatgaaaaa tactttacat ttatattgca atctaaaggt 2449081 gtgtttgata gaatacaatt tgttctattg tgaagaagat ttaaccttaa gacactgtgc 2449141 tacaggttgt atcttaggag gtgaaacaca tgccaaacat taaatcagcg attaaacgta 2449201 caaaaacaaa caacgaacgc cgcgttcata acgcgacaat caaatctgct atgcgtactg 2449261 caatcaaaca agttgaagct tctgttgcca acaacgaagc tgacaaagcg aaaactgctc 2449321 ttactgaagc agctaaacgt attgataaag cagtgaaaac aggtcttgta cacaaaaata 2449381 ccgcagctcg atacaaatca agactagcga aaaaagtgaa cggactttct gcataatata 2449441 aaaacgatcc tcaataatgg ggatcgtttt tttcatttct ttttaacagc tgtaaaagga 2449501 acagttcgag caggagctgc ttgtcctttt tcccggtttt catctcatag tccatgacgg 2449561 caagctgttc aataattaaa cggagctcct cctctgaaaa aagccttgct tgatccatcg 2449621 ccagctttac ccgaaatggg tgaactttta gattagaagc gatttgtttt tgtccgtatc 2449681 cctgttccgc gaagtacttc gtctgcagaa tcagccggaa ctgattcgaa ataagcgcca 2449741 taattttgat cggttcttca ttttgtttta gcaaatcata aaaaatttgc agactctctg 2449801 ttcgttttcg gttgacgatt ttattgatca gctcaaaaat attttgttca aggcttctag 2449861 caacaagcat ttttacatca tccagcgtaa tttcttcacg atctccaata aacgtgcaga 2449921 gcttttgaat ctcctgaaaa atcgatgaca gatgaccgtt cacaagcaga accaaatgct 2449981 ccgccgcttc cgtgccgatt gttttctgct ctgtttttgc aaggttgaca gtaaagtctg 2450041 tcgtttcctt tgcatttaat tccttcgcct ccatcataaa cgcgtgcttc tttaacgctt 2450101 tcgtcagctt ttttcgctca tcaagctttt catacggagc aagcaggaca aagactgtgt 2450161 aaggcgcagg tgattgtata tatgattcaa gcgcactgac gttgtgctca attttttctt 2450221 ttttcttttc acctgttaaa aaatatggat ttttcacaat gacaagacgc cgctccccca 2450281 taaacggaaa cgtttcagca tctgcaatcg cttgatccag cgggtcctct tccagatcaa 2450341 aaacggacag attgaaatcc tttgtctcct gatcaacgac cgtctgtctg atcctgctga 2450401 cggtttcttg cagcagatat gtctcttttc cgtataaaca ataaaccgga tggacctctc 2450461 cttttttcag gcttttccac acatcaaata ccattgttgt acgacttcct ctctttcatc 2450521 atccccttct atcctaaatt gagtttgcaa aatagtaaag aggaagcctg actgctgctt 2450581 ccccatttat attaaacgcc tgttcgcaag cccccgggac agcttgtaaa aaggcgataa 2450641 tcaccagaac agaaaacgtt accttagctt ctagattttt caaaacaatt ccattatact 2450701 taagtcagtc aggagggata aagttgaatg attttgaaaa aaacgttcaa agcaaacgaa 2450761 atgatgctgt agattcagct gttggttttg ttgtgtcctt cggatttttc gccttcttgt 2450821 ttgtcatggc aacggttatt cacctagttg gttcataaca gcgactgccc gggctgctga 2450881 tttctcggca gtctttttta gttcgtctct gttatatctg atgtatcata tggaggatag 2450941 acagaaaagg ttccaactct gtttttgtat ctatattgga tcgttccgtt ttgatctgtt 2451001 cgcagcacgc ggatagaatg tctctgtaat agttgcagaa ctttttgatg aggatgatgg 2451061 taccgattgt ttttcccggc tgagataatg gccgttttcg gctgaagctg ttggatgaat 2451121 tcttcaccgg tagagccttt gctcccatgg tgccccacct ttaacacatc tgcttttata 2451181 ttcggaaaca cgttcatcac ctcttgttcc ccttctttct ccagatcacc cgtcaagatc 2451241 cagctcatac cgcccgtctc catccacaga acgagagatg aattattttt gcttgccgga 2451301 tcaggtgctt ccggtgacag tacatggaac tgcaaatcct ttatttgcaa cacatcgcct 2451361 cgcttcacct cttcaattgc cactccctct tccctggctg cctgcagcac tttctcatct 2451421 ttaggttcag aaacgaaccc tttcggaatc acgaggcgct ttactttatg atgcttcagc 2451481 agaatctccg cctctccgat atgatcttgg tcagcgtgcg tcagaattaa agcgtcaagc 2451541 tgcttgattc ccttagcagt taaaaacgga atcagcacct tttcccccag tgaaaacgga 2451601 tgctgttttt cgcgccaagg ctctgacgag taagacaaag tgccgccggt atcaattaag 2451661 acacgacccc gctgatgcgg agcacctaca aacatgctgt caccctgtcc aatatctatc 2451721 atatccactt ctccttcgga actaagacac ggatatataa agagcagaaa catcaccgtg 2451781 cagcaaatgc ctccggttac catcaactgc gacaaggagc gtttttcaat cgccataagc 2451841 aataggatga tcgtgactgt gaataaaaaa agcaaaacag gtgcaggatg tgcgatcata 2451901 atcgtgaaca catcaacatc tgcaatgttt gtgattaacc tattgatcca gcttatcaat 2451961 aaatcaaacc agctgaaaaa caatctccca aacgaagcgg aaagacttaa tagaagaaca 2452021 cctgctacag ctcccggcaa aatacagaag gtataaaatg gtaccatcaa catattcatc 2452081 ggtacgctga tgatagaaaa ctgatgaaaa tgatatagga gaatcggaag cgagcccagc 2452141 tgagcgatga gtgatacaat tgtcagctgc cccaaggagg ttttaacctg ctgaaaaata 2452201 gaagaggata gaattaaaga aaaactgacg gcgaacgata gctgaaaacc ggcttcaaag 2452261 agatgataag gattgaagag cagaaggacg atgtacgaaa ggcaaattgc agttgcagag 2452321 cggacacgcc atttgacaag acttccagct aagtaaacac ccgacatgag agcggcgcgt 2452381 agcactgaag gagcagcgcc ggtcaacatc acatagagcg gcagaaataa cagcaacaga 2452441 attgacgcct tttctctagt tataccaagg cggatcatga tataaaacaa acctgctgtc 2452501 aaaatcccca cgtggagtcc tgatattgcc aagagatgga caacaccaag cttttgatac 2452561 gcggtaagca cttcatcctc cacgtaaaat ctgtcaccaa ctgtaagtgc ctgtacaatc 2452621 cctgtcgaat caggaggcag aaggctgttt gtgaatgata tgatatgttt tctcaagctg 2452681 agcaccttgt acttgaaatt ttcaggttcg ctgcagtttt ggatagacgt gacagagtag 2452741 ttccaatgaa tatgctgccg ataaagatac tcgttataat caaatgcacc cggcacagtt 2452801 gcgtgattcg gttcttccaa tgtaccagtc aactcacatg acattcctgg ttctatgtat 2452861 aacagctgtt ctttttcacc agcagactga atgcgatacg cagcagccca tttttcctta 2452921 tcaggtgtct caaccatcat agacatacgg tcgccgtcaa ttttgggaat agtgtcaatc 2452981 actgccttga attgataggt tccctgccga taggaagaga cattctgaga atctgtgact 2453041 gcatacagta caaaaaacaa tataaaagag aagaaacaaa caataataag aaaagcgtgc 2453101 ctcgttttga ttaaaatgat gaggagaaag aggatgaaaa gaaaaatagc ggggaaataa 2453161 gcggcggcag taattccagc cgttgccgaa gctgccgcca taggcaataa taagcgcgaa 2453221 ttacgcattc atcacacgta gctcgtgaaa agtgtattcg cctgttcatg tatctttttc 2453281 aattcttcct ccgctaaacc ggcatcagcc aatttcccta ttagacccgc tacaaatgaa 2453341 agcttttctc tgtttttcag atcaacgatc atttcatcga gttcaacctg ttcaacagtt 2453401 acacccgcct gttcaaataa ttcctgcgca tacggatgtg ttttgtaatc ctcagcataa 2453461 taaaccgttt tgataccagc ttgaataata gatttgcagc attgaatgca cggataatgc 2453521 gtcacataaa tctcggctcc atcagtcggc accccaaact tagagcattg aagaatcgca 2453581 ttcatttcag cgtgaatggt tcttgcgcaa tgatcatcta tcattaagca tccttcatct 2453641 gcacaatgta cgccgcccgc gattgaccca ttgtagcctc ctgctatcat gcgtttgtct 2453701 ctgactatag tagcgccgac agataatctc ggacatgtgc tgcgcagcgc caataaatgg 2453761 ctttgagcca taaagtattg attccatgaa attcgttcca cgttgttccc tccaaatgtt 2453821 gtgttgcctg acctttagtt tacctatcat aatgcatgac cgtcaaatca ctttactgta 2453881 atggaagact ttattttctc aaatgacttt tcacctattc ctgaaacctt agtgatatct 2453941 tcaattgttt ggaaacgacc gttttcctcc cggtatgcaa taatagcttc agctttggat 2454001 ggccccaccc ctgagatgcc ttgtaactcc tctaaggttg ctgtattgat attcaccagc 2454061 gctcccttcc ctccatcgct ttggacagac cctccgccac cttgctgcac tgctgtttcc 2454121 tctccctttt tcgggatgta caccactgtc ccgtcctgca gaatctccgc caaatttact 2454181 tgcgcttcgt ctgcttgttc actggtcccg cccgctttct caattgcctg agatactctg 2454241 tcccctgttc gcatttcata aacgccagga tgctgaacag cacctttgat gtctatcaca 2454301 attgtttcgt ttgactcgtc gttgtttgct tcctgcttta ccactgtatt ttctgtctct 2454361 gttggtacag cttgcttcac cggctcttta tttttccctg tggccagaaa gatcataatc 2454421 gctgtgaaaa cagccgcaga agccgctaaa ataattgctt tcttatgctg attcaaccaa 2454481 ttcatcgtgc atgttccccg ctttcgtcat attttatttt cataacacat atggtttaga 2454541 ggataatagc tcaaaggagg ggaaaccatt gaagataggc tttatcggca caggaaatat 2454601 gggtacgatc cttatcgaat catttattga atcaaaagcg gccgatccct caaacatgac 2454661 aatcacaaac cgcacaattg aaaaagcgtt gcacataaaa aaccgctaca acagcataaa 2454721 cgttaccgaa agtctcgaaa agctcgtttc tgaaaacgag atgattttta tttgtgttaa 2454781 gccgcttgat atatatcctt tactggcaag agcgttacct tatttaagaa aagatcatat 2454841 tctcatttca attacaagcc ccgttcaaac cgaacagctc gaacaatatg tgccgtgtca 2454901 agtggcgcga gtgatcccaa gtattacgaa cagagcgctg gcaggtgttt ctctcgtcac 2454961 tttcggcaca agctgcggcg aatctgcaaa agcgaaaatc aatgagctga tgcagcatat 2455021 ctctcatccg ctgcaaattg aaagtgacat cacgagggtt gcatcagaca tcgtaagctg 2455081 cggccccgct tttatgagct atctgattca gcggtttata gatgcagctg tttcggaaac 2455141 atcagtgtct aaacaggacg cgattttgat gtgtaaggaa atgcttgtcg gaatgggaaa 2455201 actgttagaa accgaattgt ataccctgcc tgcattacag gaaaaggttt gcgttaaagg 2455261 cggtgtaaca ggagaaggca ttaaagcgct ggaaagcggt gtgcaggata tgtttcaccg 2455321 ggtatttcaa aatactcata tgaagtacga ggaggatatt tccgcagtga aaaagcagtt 2455381 tcatgtgtag acgagtatgt catacgttcg tctgtactgc aaaagcataa aaaagcattt 2455441 taaaaaacca tcgttttagg aaacgatggt ttttgatttc tgcgccttga aaaagaggcg 2455501 ttctgattgt gctgatggct cggtatccgt aaaatcagct gtcacgcgat ggagctgaaa 2455561 gccgcagttc ttaagcattt cttcgtattc ttccaccggg aacgttcttt gctcgtgtgt 2455621 ctcatcaaaa cgatcatacg cttctccgtt ccacacaaaa aacgacatat catgaatgac 2455681 agaaagctcg tcacttccgg caaagctctg ccaaatatag ctgatatctt cgtcctggtc 2455741 agcaaatgtg ctatccggaa agacttccgc aattttaaaa gatgaatgaa catcaaacag 2455801 caggatgcct tcaggcttta atacccgaaa aacactttta aaggtttcga tcacatcatt 2455861 ttttgttttt aaataattta atgagtcaca gcatatcaca acagcgtcaa attgaccgtc 2455921 aaagccggta atctctctca tatcctgctg aagaaataaa ataggctggc tactcgatac 2455981 cttttgctgg gcgaaagaaa gcatctcttc gctgagatcg atgcctgtaa cctcgaagcc 2456041 tttttcggca agccggatgg agatttcccc cgtgccgcat gccagatcga gaatacggcc 2456101 tttttccggg agagatgctt caatccattt tgtccattga tcgtaaggcg cgtgtgacat 2456161 tagctcgtca tacacgcttg caaagccttg ataaatcatt gattcattcc aaagtcaaga 2456221 tctgcgagcg gagcgtctcc ccacagcttt tcaaggttgt agtagcttct ttcatccttg 2456281 tggaagacat ggacaactac atcgcctaga tcaacgagaa cccatcttgc ttcatcaaag 2456341 ccttccatct ttttgacttg aatgccgttt tcatcagctt gatccttgat ttcacgggca 2456401 atcgcctgta cctgtttatc tgaatttccg tggcagatca gaaaataatc agcaaccaga 2456461 gaaatacctt ccatatccag tgctaaaata tcctctgccc gtttatcatc gcaagccgca 2456521 gctgcgatct ttaaaatgga cttttggttc attcacaaat tcctcctgtt cagctgccag 2456581 acacaagcca gttatacgtt aaaaatgtgt ctggaaaaac cggttgattt tttttcataa 2456641 gaaaaaccat tgtattttta atggactgaa tcagcgcttg attcaaatct gtctcagcaa 2456701 gcttacgcac ctcatcgaca ccgggaaatg cccggtttgg ctcaatgtaa tcggcaacgt 2456761 aaatgacttt ttctaaaagt gtcatgccgg ggcggcctga ggtatgatac ctaatggcgt 2456821 caagaatgtc ttcatcttga acccctgcct ctctttggac caaataagcg ccgaccggag 2456881 cgtgccagag ctccggatta tgatccaata aatgcgcagg cattttttca cgcgcaataa 2456941 tttgtttcat ttcttctttc gggcggaatt tggcgtaatc atgaaagatt gccgctattt 2457001 ccgctttttt agaatcggct ccaaaacgct ccgcaagttc gatcgccgtg ttcatcacgc 2457061 caaccgtatg gatatatcgg tgttcggtca attgctgctt cacgcatgca agtgcctcct 2457121 cacgattcat ataaaccatt ctcctctaca tacttcttca ctttatcagg gattaagtag 2457181 tcagtgggct tcttgctttt aaaccgttcc cttatcatag ttgatgatac ctcaaattcc 2457241 ggaacgtctg caaagagaag cggataaggg gtttcaacat gaaaaccggg gcgctttact 2457301 ccaataaatt gaatgaggtt cagcagctcg tccagcttat accatttcgg caaatattca 2457361 atcatatcag cgccgataat aaagaacagc tgatcatttg gataacgctg cttcagtaaa 2457421 gaaacggtat caaaggtata tgatggccct tctctttcca tttcaacaag ctccagctta 2457481 aaggacggat tagattgaat tgcaagcttt agcatttcca cgcgatgaaa gctgtcggta 2457541 tagtcttcgt tctgtttatg cggcggaatt tgattaggca taaaccaaat ttcatcaagc 2457601 cccgcctggt acagcacctc attcgccatt aagaggtgac cattatgcgg agggtcaaac 2457661 gtgcctccga aaattccgat tttcttcatt tcaaccacct ttaaggaagc tcgatttgtt 2457721 tattttcctt tgattcctta tataacacaa tcgtattgcc gattgtctgc accaattgag 2457781 agcggcttcc ttttacaaga gcttccgcta catcgttttt atcctcttcg caattctgaa 2457841 gcacgctgac tttaatcagc tctctcgctt caagcgcctc agcaatttgt ttaatcatgt 2457901 tgtcgtttac tccgccttta cctacttgaa aaatcggcgt taaatgatgc gcttttgaac 2457961 gcaaaaaacg tttttgttta cctgttaaca ttctgttcct cctaattttc ctattacaat 2458021 agatctcatt ttttcaatat taggctcttg tccagtccac aattggaaag acaatgctgc 2458081 ctgttcaaca aacatgccca caccatcgag tgttttcaag cctttttggc ttgcttcttt 2458141 taaaagtgcc gtctgtattg gattatacac gatatcacat acgacggcac tgctcgcggc 2458201 acgctgtaat gaaagcggca catcgtccac gttcggatac atgcccacag acgttgtatg 2458261 gatgataaca tcatactgct caagacgttc ttctgcttct tttatgctta atacttcttt 2458321 attgtgaaac gagggagtag cttctgtaag ccgctttgct ttttctaacg tccggttgca 2458381 aatgtcaaat tttttcgggg tatttcggac aattgttgta aaaatggctc tcgccgctcc 2458441 gccagcgccg atcattaaga atgacagttc agagatgggc ttgtctaata ccttcattaa 2458501 tgacttcacg aagccttccc catcggtatt gtatccgaca agcttatctc cctctcttct 2458561 gaccgtgttt acggcaccga gcacttttgc actctcatca atatgatcca aataatccat 2458621 aatggaaacc ttgtgcggaa cagtcacatt gattccttgt acgcctagag ctcttattcc 2458681 ttttaccgca tcctccagat cattctcttc taccttgaag gcatgataat gtccgtcaag 2458741 cccgaggtct ttcaatgatg cgttatgaat atcaggtgac atagaatggc caataggatt 2458801 tccgataacc ccgtacagct ttttcataca cctctcccct tttcttaaat taatgaacgc 2458861 cgaacaaata catgaacgcc ttttggcgcg tatgcagtta cctttttatc agcgtcatgg 2458921 acagtaaccc agcctaaccc agagaaaacg atatctgtct ttttgtcttt tatcgtaaac 2458981 gtatgggcga ccaattcagg aaactcatcc atttcatctt tacccggagg tgtgagcaat 2459041 tcccctgcat gcttttcata aagcgcgtct gcattttcaa gttttgttct atgaatcatc 2459101 agctcattcg gcatatagca aataaaagga gatctttccc cagacacata atcaaacctt 2459161 gcaagtccgc caaaatacag tgtttgctga tcattaagct ggaatgtgcg aggcttcagc 2459221 tcctttttag gagataatat tttcaggtcc tttttattga cataatgcgc catttgatgg 2459281 ttgttgataa ttcccggtgt atcataaagc gatgaaccgt catccagcgg gatttcaatc 2459341 gcatcaaggg ttgtgccagg aaattgggat gttgtaataa tatcttcttc acctgacact 2459401 tctttaataa tccggttaat aaaggttgac tttcctacat ttgtacatcc gacaacatag 2459461 acgtcttttc cgttgcggta atgctcaatc gcgtcaatta cttctctgat tccctggccg 2459521 cgacccgcac tgaccaaaaa tacgtcaacc ggttttaagc caagctcttt cgcttcacgc 2459581 ttcatccatt ggatcagacg ctctcttttc agtgacttag gcaaaatatc cgctttattg 2459641 ccaactaata agatagggtt tccccccacc aagcgctgca gcccattaat ccagctgccg 2459701 ttaaaatcaa aaatatcaac aatttttacg accagagagt ccgtttctcc aataccgtga 2459761 agaatgttca aaaaatcatc atcagttaag gagacatctt gtatttcatt atagtttttc 2459821 agtctgaagc aacgctggca aatcacattt tctttcgtaa gcgatgcagg cggcgcgtac 2459881 cccaaacctg ttttgtcctc ggtttggatc gtaactccgc acccgataca aacaaccttt 2459941 tccatttctt actcctccca ctgaatgtgc ccttttcgtt tgagagcact cagtattctg 2460001 cgttcgacct ggcggttaaa gcgcgtaatg aatccgtcag aggaagcgac tggcacgacc 2460061 aaaatcgtat ggtagccgtt tcggtttccc ccgagtacat cggtcagcag ctggtctccg 2460121 atgacaacgc agtcctcttt tttcagctcc atattgcgca ccgctctatt aaaggcttta 2460181 cccatcggtt ttcttgcttt atagatgaat gggattccaa gcggttctga gaaaagtttc 2460241 actcttcttt cgttattatt agagacaatt gtcactttaa tgccgtgttc cttcatttct 2460301 tcaaaccact cgatcaatcg cggcgtcgcg ttcggcctgt cccattcaac aagcgtatta 2460361 tccaggtcag taataattcc ttttacattt cgttccttta atttctcagg tgtaatatga 2460421 aaaatatttt ttacaaactc gtcaggtaaa aaaaactttt ttaacaaaac ccgcaccctt 2460481 ccctttttct ttctttcaaa atgattgtcg aaaaaaatcg aacttgcgcc taaagaaaaa 2460541 ctgagcaaaa aaatttcgac aaaaattggg tttcttcacc aggtgtggat aaatttacac 2460601 acactatcca ctcttattac atcactcttt agacaaatta taaacacgat actcacaagt 2460661 tatccacttt ttggtgtgga taacagaacg attgttctta tatgcatttc atggtagatt 2460721 aaagataact tcaacctcag atgaatgcaa cttatcattg tatgcgttaa aatcatgaat 2460781 gattccaact tttaaggagg tgcctctccc attaattggg ttcctagcat gagaaaactg 2460841 tctgatgaat tactaataga atcttatttc aaagccaccg aaatgaattt aaaccgtgac 2460901 tttattgagt taattgaaaa cgaaataaaa agaagatcgc tcggacatat tatttccgta 2460961 tcttcttaat aggaatttgt ctattttttc cgggcgtatt tccttttttt actcagatga 2461021 ctgatattat atcactttgg ctgcgcgctt tactactatt ttcagcaaaa aacaccccta 2461081 aaaagaggtg ttttaaaggg ccggttatta tgctaaccag tatatgccgc ccacaacaag 2461141 gagaacaaca actaaaacaa caataaaagc gtatccatat gctctgcctg cgccatacat 2461201 gtgaagcgcc tccttaataa ggttttataa cagcctatgt aggagaaata aatcggacta 2461261 ggcggttgtc cggctcaacg ctgcaggatc tgcccatctt gtattccttc atatacgatc 2461321 cttgcccctt taggtgtcat atgatttcca gaaggatcta taagaccaga ttggataagc 2461381 gcttcatcag ttgcttttcc gccgtctgct tctataaaat gcttccagtt atctacaaga 2461441 gggacatcca ggcgcttcga cacatctctt gtaatatcgt tatatgagtt gtgccatttc 2461501 cttgctccgc cttttggttc aaaagcagct gcttgatatc tggaatagta aaacaaatga 2461561 tgcttcccat taccttctat aattgggata cacgtcatta agattggctt gatcccgtgt 2461621 tttctgcttt cttcaataaa ataaaccaga ttttctctaa aacgctgctt cgacactctc 2461681 ggtttcccct cagtcagtat ggcagcgtca ttggttccga acataataaa caaatacttc 2461741 ggtttttgat ccagcacatc tgtctgaaat cggagacggg catcctctgt cgtctgtccg 2461801 ccgattcccg cattgagtat atcaaggtta ccgcgctcag ctgtttttaa tatattgacc 2461861 cactgctgtg cttttggata atcgcgataa tcccaattag agccacgcgt attactgtca 2461921 ccaaatgcta caacgtcttc gtatcccctt ccctcgcatc ctgctgtaac gaacagcaga 2461981 aggaaaagga tgataaaatg tttcatcttt acacccccaa aagcctcact ttaatgttat 2462041 acctctgttt ctcttcgttc aatgaagagt ttttcgctat cactgttttt tcctatagtt 2462101 aacgtgtccc cctcagtgaa tatcattctg ctttcattgc ggcgcagctg atgatttttt 2462161 aaaattccct tctttccaat ctgaaaaaca cacaaaccaa agaaaagaaa ataacctgaa 2462221 tccgcactgg aaacaggtta tccgttaaat cctgcattta ctttaacttc gatttaagct 2462281 tggcctttgt ttttggccca taaatcccgt ctgcagttaa tccgttcatg agttgaaaac 2462341 gcttgacggc attcgctgtt ttcggtccgt aaactccatc tatgccattg tttttggctc 2462401 ccttatcagg gtaaaagtga agtacagcta aagccttttg cagctggaga atgtttgtgc 2462461 cctttcgata aggcgaagtg agctttataa ccccagacgg cagaggatat gatggtgaag 2462521 tttcttttgg aggtgtatcc gaggaagaaa ttccgtttag aaaagagttc cagtggtcca 2462581 agagtttccg cggacattct ttcccggacc actttttgtg gggaacaaca cgatttaacg 2462641 gaatattgtt ttccttcatc agctttctga tcagccactg ggcatttgat gttgcttttt 2462701 caaaatcgcc gtcagcattt tcacagattt caatcccgat cgatttgcgg tttcctgtcc 2462761 cgtttgtacc gtctcccgca tgccagccgt tttcatctat cgggagatgc tgataaatga 2462821 ctgaatcgtc aactgtaaaa tgccagcttt cggatgtgtt cgggtttttc acaaacttgg 2462881 cgtgcatttt cgcatcagcg cctttggctg tattcgctgt attatgcacc gtaatataag 2462941 caggcgccat cgcatagcca ggacgattat catttgatac cggtataaaa tcctttttta 2463001 tggttaccat ttctatccct ccctattaat aagaatgcag aaaacagaga gatggacagc 2463061 cttttttatg aggtaaaaaa gaattgtgtt cttaacctgg ttttcagttg aacagctgaa 2463121 atggcaccag ttatactaat ttagatgacg gaggttttga ctcctgacat cacctaagtt 2463181 gggagtgacc atagacatgt taaaaaaagt aataggtata cttgtgatta tcgctatcat 2463241 ttcagttggt ttttttcaga aagaagcttg gcttgatgca atcaaagcag gagggatgtt 2463301 ttccgtttta tttagtatgc tgctgattgc tgccgatgtt tttttcccaa tagtgccgtt 2463361 tgctttgatt gctgctttaa atggcgcagt gttcgggact gcaaatggaa tttggattac 2463421 actgaccggc tcaatgcttg gtacaatatt gctgtttttt ctcgccaggt acagttttag 2463481 agattgggcc agaaaaaaag ttcaggccta tcctgccata caaagctacg aggcttcctt 2463541 caacaaaaac gcttttaccg ctgttttatt aggaaggctg atacctgtca taccttcact 2463601 tgtaatgaac gtgatctgcg ggctgagcca ggttcgctgg catgtttttt tctttgcgtc 2463661 tttaataggg aaaatcccca atattgttgt tgtcactatt gcaggtgcca atttcaccag 2463721 caataaatta ttgtctatca gcatttacgg tacatatatt ctgatcatca tgctggtcat 2463781 ttataaaaag ttccctcatc ttctgaaggt gccaaaaaaa taaggaggct tgttggcccc 2463841 cttacttttt ttctgtcgca tggcctccaa attcatttcg aagcgcagca accacctttc 2463901 ctgtaaacgt atcgtctgtt aaagaacggt atctcatcat tagtgacatg gcgatgaccg 2463961 gcgttgccgt ctgcagatca agcgcggttt ccaccgtcca ttttccttca cctgaggaat 2464021 gcataatgcc cttgatctga tccagtttcg catccttagc gaaagctcgc tcagtcagtc 2464081 ccataagcca agaacgaatg acagaaccat gattccacac tctggcaacc ttctcgtagt 2464141 caaaatcaaa ttggctgttt tcaagcactt cgaatccttc accaatcgcg gccatcattc 2464201 catactcaat tccattatgg atcattttta aaaaatgtcc gcttcccgct tcaccagcgt 2464261 atagataacc attttcgacg gcagtatcac gaaaaagcgg ttccacaatc tcccatgctt 2464321 catgatcgcc ccccaccata aaacaggctc catgccgtgc gccttccatt ccgcccgacg 2464381 ttccggcatc gagataatgg atacccgctt ctttcatttg attgtagcgg cgaattgatt 2464441 ctttataatg agagtttcca gcttcgataa tcatatcgcc tttacttaat aaaggtgata 2464501 catcacgcaa aacagcatcg acaatgccat gcggtaccat aacccatagg atgcgcggcg 2464561 ggtgtaataa agaaatgaac tctttaagat ttgttgtccc ctcagccccg tatgctttca 2464621 gttcatcaac agccgcttga tttacatcat atccaaccac ttgatgattg cggtcaatga 2464681 attgctttcc tatgtttatg cccattttcc ctaagccgat taatccgatt ttcatatctg 2464741 ttcctcctga ttgtctaaaa agcctttact ctttatgttc cctatggatt gtattgtgat 2464801 acgcagaaaa caaatggggc ttacatcgtc tgcgcatgta aattttattt ttcatgaccg 2464861 acggcgcctg ccagttctat tactgaatct ctttatatcc ataattatcg ctttatcctt 2464921 gatttaccat cagtttaagt taaaatatgg gaaggaattc gattttttca gtaaaaagaa 2464981 ggtgacatgt tgcagaatca atctcatact cttattggag ttacgaaaac cgctgtattc 2465041 tttttatacg ctgcacttgc aatcatcggt tttgcaatcg ggtattttat tccgcagatt 2465101 gcgaaatggg cattatccct cccctggatc cctcttgaag gaccacttcg gctcattacc 2465161 tcttttcagg gatctacagc ttcatttatc actgctcttc tcggtatgtg tgcggggatt 2465221 tggttcgctc attctgttat tgcaatgctg ctgtctgtca aaattacaga tcacacagtg 2465281 gaattcatca aaggaaaaaa agtgcaaaca attcattccg atgacatcgc tcttgtattt 2465341 atggatcaca aacggcttgt cctcctggga acagccggat atgaattggt acgggaagaa 2465401 attgatgaaa aaccagtaaa cgttgagaag gcctttagac agcatcatta cgaatgggca 2465461 acagatggtg atccgtttaa agatcaattt cgccgatgga ttcctgatgc accagaccta 2465521 tcgcaaggcg cccatgcctt attaaaagct cgtcacaaag cactgcagga cgaagaaaaa 2465581 gacgatattg aagaattccg tctcgaactg gcacagctgg gcatcgttgt acgggacgaa 2465641 ggcacacgcc aatattggcg aaaagcagaa acctatcccc cgaaaattca gctcggcgaa 2465701 ggattgtaac aacagaggct caagaaagag cctcttcttt actactgcac aataaacagc 2465761 actctggtac cgtcaggata gctgctcatt tgattcccta cccacgagcc ggcgccgcga 2465821 ttatcagaag gcgtcacata tcggacatca gcccctgcac cgccttcctc gcagaccgcc 2465881 atcggccact catcccggtc atagcccggc ttggtcggga ttccctttaa agattcctcc 2465941 cgccttttgt ctgctccatc tctgtcaatg gtacaaatat ctggatgtcc ctctgcaatc 2466001 gcatccctaa tatgactgcc ggtttccgga taacgagaca gcggaaaata taacactttg 2466061 tcatacgaag atgcgccttg gatctgttgc ggaaccatta aacaaagaag aactgctgca 2466121 gcaagaaaca ggcctgccat ccattttttc atccccatcc ccccatacct ttgttcattt 2466181 caatgtatgg gcgcttgatg aagaatattt ttaacatttg aagttagtat gctgcttacc 2466241 aaagccggac tcccccgcga gaaatttccc ggtacagaca cagacagcct cccggtcaca 2466301 tacatttaca tataggcttt tgcctacata cttttgtgga ggtgacgatg gtgacaggtg 2466361 ttttcgcagc gctcggcttt gttgttaaag agcttgtctt tttagtatct tacgtgaaaa 2466421 acaatgcctt tccacaaccg ctctcaagca gcgaagaaaa aaaatactta gagctcatgg 2466481 ctaaagggga tgaacatgcc agaaacatgc tgattgagca taatcttcgc ttggtcgccc 2466541 atattgtgaa aaagttcgaa aatacaggtg aggatgcaga ggacttaatc tccatcggaa 2466601 cgatcgggct tattaaagga attgaaagct attccgctgg aaaagggaca aagctggcga 2466661 cgtatgcagc gaggtgtatt gaaaatgaga ttgtaattac aaaagggggg tgcatacacc 2466721 cctctttaat acgtttcaat atatatggtg tcagaatcca caatggtaac ttctttcacg 2466781 ataaagttaa caattgtttt tttatcttca agagttaagt tatctgcacc gattgattga 2466841 aaatagtcga tggctctttt tagagcattt tcacttgagc tcgtatcatc taggactttc 2466901 atttttgact ggatttcgtt acacttttca gtaagctgat tttgcttttt ttgcagttca 2466961 ataatttgtg ctttgatttc atctatgtct aaatcatcgt catcgcttag gctgattagc 2467021 gttaaaagac gcttgcggcc tttttttgtt ttctctatct ctttttcaat aagttctaat 2467081 tcatcagaca ggtgatttga ttgttcagcc tctttaaaag aaacatactt ttgaggattt 2467141 gtgatgaatt taaaaatttc accccataca tgccggttca atttattctc agacatttct 2467201 tttccgcagc cgcggtcctt tgcgccagaa taatttttcc ggcaagtata tacatagtag 2467261 tctttaccat gtgattttct tttcttccct gtcatggtat ttccgcattt tccgcatcta 2467321 accaaacccg ataacaagta attgtgaggg ctgatactca agtgttttct tttactttga 2467381 cctaagagtt cttgagcata atcccattgt tcagctggaa caattgctgg aattgtcaca 2467441 gtgatttgtt cttcttcagg ccttatttta attatagatt tgttccctgc ctgctttgaa 2467501 acataggaac cctctgtatc atatttatac tgtctatgtt cacccttata ggaagagttc 2467561 attaatattt gccgaacaac ctgcctgtgc catactttgg cgcctttttt tgttttaacc 2467621 cccatctgag ttaaatgtag agcaatacca tttactctgc cgaaaaaagg gcttttatga 2467681 tcggtgaaat agttaaaaat catccgaatg atttttgctt cctcttctaa tatctcaaga 2467741 gttcttttct ctttaacaaa tttatagcca tatagtttag aatctttaat gatcatgcct 2467801 tttttcattt tttgaagtcg gccgcttgat gtccgttctt tgattttggc tttttcaaat 2467861 tctgagattg ccccgcgcat tgcgaaaaac aattgacctt ctggagaatt ggcgtattca 2467921 ccatttacaa aaatcaaagg tatgtttcgc tttcgcaatt cgtcatcaat gattagctga 2467981 ttcattaatt tccgagaaag acggtcagga tcgtaacaaa tgacttgact tataagtccc 2468041 ttgcttgcat cctccctcaa gcgattcaaa gccggacgtt ctaaaagctc tcctgaaaat 2468101 ccttcatctg catacttcag cacatcttta gtccctgctt tctttataca ggcctcgatt 2468161 tggctgtcga tgctcgatcc cttgatcgct tgttcctcgg tcgataccct tacatatatt 2468221 gctatcaccc tgaatctcct tcctataaag ttttattaaa taatgatagc aatcgttaat 2468281 gcatttgtca gcttgcggtc cctcgatgat tatcactttc ataaaatgca tcaccccttg 2468341 ggtaatgcta tgtaacagct gtttgtccaa atgaggagat tttaaattaa actatagtgt 2468401 tattaaacgt ttcaatgaat atgcaaaaaa tttaaaaaaa gttgttgtga cttttctaca 2468461 ctcctttagg tcctcaatag aaaagatttt attttctatg cctcaacatt cgcttattat 2468521 agttttcaat gatttattat tatttgagag tacaatggag tagtgttttt cattgttaga 2468581 tagttaatga catttcactg gtgtcaagtt cgtatagcta gacattaata aaaaaaggac 2468641 acatataaat atgcatcctt taacaaaaga gtttatttat ttccctgttt cagcaaattc 2468701 cttcaaccta ttccctattt catcacgaac tctttggaaa aacgcccatt tttcttcttc 2468761 tgtcccttgt gctcttgccg gatcatcaaa accccaatgc tcacgtttta catgtggagg 2468821 cgtcatcggg catttatcag cagcatctcc acaaagcgta acaactaaat cagcattgtt 2468881 cagaatatca gaatcgatta tatctgacgt ttgattagag atatctatac caacttcctt 2468941 catcgcttta acagcattcg gatttaatcc atgtgcttct atccccgcgc tatacacttt 2469001 ccactcatca cctaaatatt gtttagccca tccttcagcc atttggctcc ggcaagagtt 2469061 ccctgtacat aaaaagtaaa tgattttatt ctccatatat tccacctcta catcgagtga 2469121 cttccaaagt attttcgttg aaaccataaa gcaaccttaa caagtgctat catgactggc 2469181 acttctacaa gcggaccaat tacggcggca aatgctgcac ccgaatgaat tcgatatcaa 2469241 gcttcgcact taaacacagc ggaatttata atatatgctt ggacagccgt aaaagccgaa 2469301 ctgaacaatg gtatgatttt gctcatgaat tttgccatat atatagacat gaaggcgata 2469361 aaaaaacaat gcctgcaact tggactgatt atttggattg gcagtccaat tattttacat 2469421 atcacttttg cattccaact tgcatgttgc gtaatatcaa ccttccgtac atacaatcac 2469481 atgcaattga aaatgtagct tggttattta aggtatcccc ttcattcgct aagaaacgtt 2469541 taagcattta ttacaggaaa ctgactcaac atttatttag tcaaactgtt acgggaaatt 2469601 tatgcccccc ctttttgtaa tgaataatga aatcctcatg catttgcgcg cattgaaaaa 2469661 aacaaaaaaa gacgtctccc ttcacgatcc gatcgggcag gataaggaag ggaatgaaat 2469721 aagcctgatt gacgttttga aatcagaaaa cgaagacgtg atagatacga tccagctcaa 2469781 tatggagctt gaaaaagtga aacaatacat tgacatttta gatgaccgtg agaaggaagt 2469841 gattgtcggg cggtttggac ttgatttgaa gaaggaaaaa acgcagcgag agattgccaa 2469901 agaactcggt atctcacgca gctatgtatc gcggattgaa aagcgggcgc tgatgaagat 2469961 gtttcatgag ttttatcggg cagagaagga aaagcggaag aaggcgaagg ggaaataatg 2470021 cagaagaagc cggatctcat actccggctt tctctatttg aaagagttat gaaaatcatt 2470081 tttttcatcg ctgataagct ctccgagaaa gacaggcagg atcgtaacaa ataacttgac 2470141 ttataatcct cccgcaggca ttcaaagccg gacgttctaa aagctctcct gagaaaatcc 2470201 ttagatcggt atacttcagt acatctttag tccctgcttt ctttatacag gcctcgatct 2470261 ggctgtcgat gctcgatccc ttgatcgctt gttccacgat atattgctat caccctggat 2470321 ctcctgccta taaagtttta ttaaataatg atagcaatcg ttcatgcatt tgtcagtttg 2470381 cagtccctcg atgattatta ccttcataaa atacatcacc ccttgggtaa tgctgcgtaa 2470441 tacctgtttg tcctaatgag gtgattttca atgagtatga aaacaaataa aaaaaccgat 2470501 ggtttgtacc atcgatctgt tttctatatc actaggccct caatatagta aatctagctc 2470561 attggttatg aaagcttatt ttcattacac actatatatt catttgttat catttctata 2470621 cgtttatatc aattatggta aaaaatggtt acaaaaaccc aataaacgtc caacctaact 2470681 ttttcatctt atttattaag aattttaacc tcttccttgt gaaataaaga agcgattttc 2470741 atctccaaac agttaatgct atttcatcgg gacatgtctg ttaaagtagc caataaatac 2470801 attcggatat ccacttacaa ccacgattca atttgatcca ctacagattt ctgagctgac 2470861 attaaacaga tagagttata aaaatctgta ccagttccct ttcacaatta ggacatttcg 2470921 gcggcgtttc ggcataatgc gaactaattt attaatgttc aacaacagaa tttcgtctat 2470981 tggcaataaa gaatccacaa atcattgcaa gaatggccat cgcccaccag aacgttgaga 2471041 tcgcctgatc atgatcgatg ataatcaaac gaatgacagc tgtgatgcca atataaatga 2471101 agtagcgaag cggaaaatga aagtctgatt tgaagtattt gataatcaaa gcaatgaact 2471161 caaagtacat gaagaatata agcagttctc caagcatctc ataatagctg tccactttgt 2471221 tgaacagtga cttgtatacg aatagcacaa tgtaccaagt ctcgctgatc agaagtgcgc 2471281 ttaaggctaa cgccagaaag aacagacaga cgttgagaag cgcttgtaac aggtaaggca 2471341 cctttttgaa tttgttagaa aatctcatca tgttgtctcc tatttcaata tattcgtggt 2471401 ttttattctc agcctacatc ttggtgttcc aaaatcgtag cacaatgtag tacttagaat 2471461 tcttttgtat actgtgaaac tgtccctgca tgcgggacat cattcgcgca atgcttcttt 2471521 caccgagtcc gttgctttcc ggtgttatat ctgcaagttt aatcgtattg ctaacatgga 2471581 tctcaaatat ctcttgatcc gatacaaacg tgatactgat tttttcttcc ggatctgcgt 2471641 atttcaataa gtttgacatc acattatcaa atacacgacc aagctcctcc aaattcacgt 2471701 taatataggt ttccggcagc tcgcctgaaa tatggacccg aaaatgctcc tgatgaagga 2471761 tagcaatctg atctgatatt agatcgtaga tcacttcttt cactgcaacg gtctccagat 2471821 cggcctcata ttccttgttc agcaggaaat acgcaaacag attgtcagac aagcttttta 2471881 attgcagtgc tttaccataa gcattggcta cataccgatc tttgctggca cccgcttcgc 2471941 ctccctcttt tttggcaaac tccagattca tgatcagcga cgtcagcggt gtgcgcatat 2472001 cgtgcgacat ttcggtaacc aggctgcggc tctcagcttg caattcctcg atagctttaa 2472061 gtttatccag gaaagctttc cgcagatcct caatgctctt tgcaatcatc gctaattcat 2472121 catgcccttt tatcgtcatc tcgtagtcca gttcgccccc ttcaagaata tgaatctctt 2472181 gatgaatcgt tttaaggtag cgaagacttt ggcgaattcc gaagagaaca atgattaaaa 2472241 agatgagggt tgccccgagc aaatccaatg caaaggccag atcataatat cgggaagagt 2472301 agaaaccgtc gataatgact cgtccttcac catcgctaaa cttgacagga tgtgaatgat 2472361 tttgagcgta ctgagtcagc ttttcctttc cataatccga ttcggaataa atagaatcat 2472421 attgcagctc ctgatccttg aatatggtga ggttaatgta attttctttt ttgacccact 2472481 cgccaaacgc ttttctatct gatgtagaca actcattttc tgaaacgtac ttgctgaatt 2472541 tttgaatgta tcttgctgac tcctcgtgat aatactcttc cgaactcaga tatccctcga 2472601 tcagatcatc tgtgatcttt tgcaacgtca gaaagatcac accactcaca atcgcagcaa 2472661 ccattatcag caaagccagt tttttggtta gcgtaaattt aagatgcgcc aaatcgatat 2472721 cctcttcccc attcagtttt tatataaacc ggacgtgccg gatcatcctc aattttggag 2472781 cgcagcttcc gtatatgcac catcaccgta ttgttggaac agtaaaagta aggctgtccc 2472841 cacacactct catatatatt ttgggcagaa aatattttgt tgcgtttgtt catcagaagt 2472901 ttcaggatac gatactccag atctgacaac ttgatttgct tctcctcttt ccacacctca 2472961 ttaaattctt cgctcactct tagtttgccc ccgataagaa atgtttcttc ctgttccttc 2473021 ttttcctgat agatagtata tctgcgtaat tgagcaatca ctctagcgtg aagttcctct 2473081 tccgagaatg gtttagtcat ataatcatcg ccgccggcga gtaatccctc agttttatcg 2473141 agtgtactcg atctggccgt cagaaacaga atcgggacgt tagaggattt cctgatgtgc 2473201 tgacatgttt caattcccga aatgcctggc atcataatat ccaaaataac caaatcaagc 2473261 gagtcattca caagttgcaa tgctcgcttt ccatccttgg ctcttagcac ctcgtaacct 2473321 gcacgtgtaa gggattcctc caaaagatca ccaatatcct catcatcctc tacgactaat 2473381 attcgatagg ccatgtctct ctcacctcat gattcttgtt gttatttctc gtgtgtcctt 2473441 actatatatc gttcatagta ataagtacgt tataagatac tacgtaaatc ttaacaattt 2473501 atgaaagctg atgctcgcca caaatttgtc acattttcta aaaaaaatga tgactcttca 2473561 taaattgtta agattcggtc tttatattta tccattgtaa ggctcaagtt tttcagatcc 2473621 gcactacaca ttgccgtgat aaatgggaaa ggagtattga tatgattgta caaaaagaag 2473681 gacgcgggca accggtgagt ctgcgggaac gggttcattt tctggacatc gtacgaggat 2473741 ttgccttgct tggcattatt attgtcaatt attttctgat cgtagattca gtaaagggat 2473801 tcgaaatggc ctccgatgac gtactgcata agctggtttc ctggtttgcc gaagggaaat 2473861 tcgttacgtt attctccttc ctgttcggag tcgggtttat gatctttatg gatcgagccg 2473921 cgcagaaggt agagagtccc aacaagctgt ttgcccgcag gttatctatc ctgttgggat 2473981 ttggcatttt gcacatcaca tttgtttggg tcggtgacat attggccttt tacgccgtaa 2474041 gtggcttcct gttactcgcc ttctataaac gcacggccaa aacggtgctt agatggatta 2474101 tcgcacttat cgtgtttcaa ttcctgactc ctgttttcac aatgttgtac aatgtcatca 2474161 atactgcagg gtcaaaaaac ccgaattttt cagagtttac tttgtttagc cacagcagcc 2474221 ttacctacat ggaatccatc agcactcggt ggacagatat ggtcacgatg gctgccggct 2474281 ctttctctat gatctattcc atgtttctca tgtttctgct gggcgtgtac tttgttaaga 2474341 tggaattttt caaagacatg gaagcgaaaa agcctatatg gaagcgtatc tggatcatta 2474401 gcacaatcgc ttttctaata acacaaagca gtatattact agacatgttt aatctttctg 2474461 agaatatgct gtggaaggac atttcctctg tcttgggtca aaatggcggc ttaaccggaa 2474521 gtatgtttta tatgagcact tttgcaatgc tgtttctata ccttcctcag ctgcgaggcc 2474581 ctatgatgat attcaccaaa gtcggacgga tgtcattgac ctgttatctg cttcactcta 2474641 tcattggaac agttctgttc ctcaggtacg gattcgggct tgcggatcat attcaatccg 2474701 ccggcacgtt catgttcagt ctggccgtgt acttcgttct tatgagcttt agtacattgt 2474761 ggttgaaacg gtttaggtac ggtccgatgg aattagtatg gcgcaagctg acgtacggca 2474821 aagtaaacgg gagtcccaaa gcaactccgc tgcattcgga aaaatctatt cagaaataac 2474881 ccccttgcac agattgcatg acttcaaatt agtgttgttg aatgaagcgg gcattaaacg 2474941 gacagatttg atatatggac tagttatttt tatatcattt aggcttcttt gggctaataa 2475001 atccaccaga gtttactcaa tgtgcattgc tcatgatcga atctaaattg aatcttttac 2475061 gcatgttcat agtcaaaggc gcctcattcg actatttttg taacttttcg caggaaaaat 2475121 tcgagaatga tgacaaatcc cgcatacgac acttaatacg gtagtgaaca atagtaaatt 2475181 agggttacat gcagcttgtt ttccaatgaa acaaagaaaa agaatcatac aaaaagacag 2475241 gagaaagctt ttgaagtatt ttaacgccaa atttaccgcg gaagaaagag cgatggaatc 2475301 acttttttgt gaaaaggcct cgcagagcag ctcgaatgtt ttactgaacg actgaactct 2475361 atattttagc aactgaggga gtgaacaatc atgaaaacta aaaatgaacc aaaagttatt 2475421 ctggaactag caaaggaatc tgatctgcca gaattccaaa aaaaattaca agaagccttt 2475481 gcgatcgccg tgattgaaac gttcggtgat tgcgaagatg ggccgattcc atcggacaat 2475541 gatgttcagg agtctttcaa tgctcccgga gcagtggtat atcatattct tcaggatggt 2475601 aagaatgtcg gtggtgcagt agtacgtatc aacagccaaa caaatcataa ttcgctagat 2475661 ttattctatg tatctccaga atatcacagc caagggattg gtctttctgc ttggaaagcc 2475721 attgaagcac agtatccgga tactgtgctt tgggaaaccg tgacacctta tttcgaaaag 2475781 cgaaatatca acttctatgt gaataagtgt ggatttcata tcgtagagtt ctacaatgaa 2475841 catcactcta atccgcatat gcatcgcaat ggacgtgaag atgacaagcc cctactgaat 2475901 gatgatgact ttttcagatt tgtaaagatt atgaaaaaaa aggactaaac aattgaacac 2475961 ggcgagatgc cgcagagagt tgctggtaac ttttttatat ttcattatca gaggaaggta 2476021 ataatgatgt ttaaaaggtg ttttgatccc tgtctcataa acaggggtca aaacaccttt 2476081 gaatcatcgg tttcttttct gacatatacc acgcccacta gtccctcaac atagtaaaaa 2476141 catatcatga gttacaaaag cttttattca aagcatatgt ttattttatt tatacttatt 2476201 ttcatcattt ttcagaattc tggacacaaa tcgggtacct attagaggcc aaggaactct 2476261 acatttcatt aagaaatacg tactcattgc cctgctttaa ttaattttaa gccctcgcac 2476321 tatgcccccc cctgaattaa gtatttgatg taactttgaa attaagttta tgaaaatctg 2476381 tcacaaaccc ttatttcata acacatcatt tgtttcagct tccctcgcga ataccggatt 2476441 aatgctcggc tttaagatag tcaaccaatc tctccgcact gttcttaaca tcttcttttg 2476501 aaagatgaag tgtcccatat tgtgtaaacg caggaagaaa acgcattcct atatagttag 2476561 cagtgacttg aaacggtctg ataagctcgc tgatcgtgat attatattct ccgcctgctt 2476621 gataatcaga ttcctgtgcg cctaaggaga tagctaagag tagttctttt ccatgcaatt 2476681 tagttcctcc agttccataa gcccagccat gtgttaacac atcatcttcc cattgtttga 2476741 gtaacgcggg actgctgtac caatacattg ggaactgaaa aacgatacgc tcatgatcta 2476801 acaggagctg ctgctctttt tctacatcaa tgataaaatt agggtattca ccgtacaggt 2476861 catgaaccgt aatgtctttc tcttgcttta aacgattcat ccaggttttg ttgacaacag 2476921 acgtttccaa attaggatgt ataacgataa ctaatgtttt cattagactg attatccttt 2476981 ctttgccaat tagttattat tttttacgat aatgaattga ttctaatttt aaaatagcaa 2477041 ctttatttac acctatttta tcctttttca tgaattcagg gcaactaatt gggcaccaaa 2477101 atcaatgatg acttaagaca ttgttttgta gaaatccgat atacagaata atccattatt 2477161 tagaaaattt ctaccttttc cctcaatcct taccaattta aactcattaa ggagatactt 2477221 tatcaccaac tttaaataat aatggaataa gtgctaataa aataattcct acaaccaacg 2477281 tagatattat taactccttc catacaatca aattctttaa aaacatttga taaataacta 2477341 atgagtttac tggaatgtta agcaataagc ccgtaagaag tccaggtgca tactttttca 2477401 ttacaacagt tgcgataaga tgtggaaaaa tagcgttgat aaccatagaa cctagaaagc 2477461 caatgaaaat ccattttgca atatctgatt ctggcatata taaaaaacca aatgcagata 2477521 aataagccaa catagttata acaatgacag caaaatgaaa ttcatttgaa gttactggct 2477581 tttgaaactt tgaagattgt tgtgaccact caggtaacca aatagcttcc tcaatattat 2477641 gaagtgtaat agcaaaacaa aaaaatgcta cgaaataaac cacctatcat ttcctcctcg 2477701 gtgccacaac caatatggtt tggcaacatt atattacatt tgaggctgat tggatatggt 2477761 gttaaaagag agaagaatct gccttagtag ttgcttctta attatatgtg caataacgtg 2477821 ttgttacgtg gcatgtcata ttcaaatata ataactctaa agcaaacaaa gatacctata 2477881 tagtttggca tcctcttttt tagttcgagt ccctctattt attttgggca caaaatagac 2477941 ataatttata ttgactcatt atacccatca cataccatac cccttaaacc aatcaggatt 2478001 aaaatgtttt aaaaaaggtg atcaaagatt aagttatggt ctcttttatt ttatgtatgc 2478061 tgtcttaatg caaaacaaca ctggacacca ctaagtcaaa tgcatttcat ggtactatag 2478121 tcaagacttg tccaagtcac cattatcaaa atgaatttca tcaaacactt gaaacattta 2478181 ttgaacgcgg ccaagtgtca taacattaat aagaaaccaa cgagtgatga atcttttaat 2478241 ctttcatttt acccgctggc tcatatcaaa ggagctctaa ccaaatttta atagctgtcg 2478301 cacctattaa ttgcgctaaa acccattgca ggaattttgt atttactttt tgcccaactg 2478361 atgcgccaat aggagaagct attaaactag taatcataag aaccagagct ggtacaaaaa 2478421 gaacctggcc cgtgattact tttccaactg ttgcgccaat ggatgaaaga aatgtaatcg 2478481 caagagatga agcgactgtg actctaacag gaatatttaa aatcgataac ataatgggga 2478541 ctaggataaa ggcgccgcca gctcctaaaa tacctgatac gccaccaatg ataaacgcta 2478601 aggaagaagc caaccattta ttaaatatca cttccttatc ttcgctatgt tcttgtcctt 2478661 tctgtccttt tttaggtata aacattaaaa taactgctat aatagccaga attccgtata 2478721 taaagttaat tcctttttca gatatataat gagaaaagta actccccaat acactcccta 2478781 aaaggatgct gcttcccatg taaataatta atgttttatt tataagacca ctcttacgat 2478841 aagcccaaac accgccgagt gtcgcaaaaa aaacttgaat agcccctatc cctgaaactt 2478901 catgggcagt taatgacatc actcccacta aagaaggaat gtacaatagc attggataat 2478961 taataactgc tccgccaata ccaatcattc cggaaataaa ggcaccaata aaccctataa 2479021 tgaaaagagt tgtgataaag gcaatatcca ttttatttgc ctcctttcat aggaaaaggg 2479081 tatctttcta ttcgataccc tttcacattc attagccttt ttgaatccaa aatttcaata 2479141 tatcgccctc gtccgtttgc tctaaaaggt catgtccgcc tgatttagac caggctgtaa 2479201 gatcattttt ggctccctta tctgttgcat gcacttctaa tatttgacct gattccagtt 2479261 cattcatcgc tttttttgtt ctgacaattg gcattgggca tgccaagcct tttgcgtcta 2479321 atactttatc tgatttcatg ttcttctctc ctctttttag cagaaacttg tgttaccgta 2479381 ttgcacagcg gtttgggcca atctccattt cacgctgttt ttcttcatct gggctgattt 2479441 tccccatgtt tgtttctcga atctcttggt atgcatttgg ttgcggaggc aaatgatctg 2479501 ttactaggtg tctaaattct gtttcatccg caatgttcaa accatggttc tcgctaaata 2479561 atgtacttag ttgtttacca acacttccat tctcatttag ctcgtcaatg atcataaagt 2479621 gtgccggtaa tacaattaaa tcctttgata acgctttgta acggctataa agcgtttttc 2479681 ttaaatctcc tacccaatct tctgccatac cggctaagtc tggtctgccg attgaatcaa 2479741 taaacaagat atcacctgaa agaagatact ggtcatcgac aatgaaagaa gtggagccaa 2479801 tcgtgtgccc cggagaataa atcggttgaa ttttaatcgt tgtatttcca ataataatgt 2479861 catttccttc ttccaacggc tgataatcga attccacttc ttcagcatct ttaggcggta 2479921 accagtaggt tgcttttgtt ttttcagcaa tgactctgcc gcctgaaata tggtccgcgt 2479981 gaagatgtgt atcaaatacg tgagtaatcg ttgcaccctt ccccttcgca aaatctataa 2480041 agaaattcac catacgtgtc gcatcaataa ttgctgcttc accattggaa atgaccatgt 2480101 atgacaagca gcctttaccg attcgaacaa actgatacat ctcaccgcca tcttttaaat 2480161 ccccgacttt taccggctct aaatgttcgc tccatgcttt cattccaccc ttaaggtagg 2480221 atacagaatg acctgcttca gaaagcattt cggataccat gacggatgaa ccttcttttg 2480281 cgcaaacgac cagcacttct ttatcagaag gaattttctc caagatatct tctacgccat 2480341 ctaaaagatc aaaataagga acattcaaat ggtcaaagtc atgcccttct atcttccaat 2480401 cactaaaatc attttcatta cgcacatcca aaataaataa aggttctttg ttaaagattt 2480461 ttttgtcact tcttttgggg tcattgcctt tacggtcatg tttcaatacc tcctatatca 2480521 aatcttttag cgggactaaa acgttaagga tacatcagca tctttcgtaa aaccaaaaaa 2480581 ggtaacagcc ccgcctactt cgattccttc cataaaatca tcttttgtta aacccataac 2480641 gtccatcgtt atttgacaac caaatcatgc aactcccatt tcaatcagtt aagaatagaa 2480701 ggcacatttg cgttcctaca accttctgcg acatgctctt ttccttgtcg caatattaca 2480761 gactttataa gcatcaaaca gaccgctatt tgccgcaata atcgctactc ttgtactcat 2480821 ctgttcatca tgctttttat ttattcggtt ttacctgtcc aatcccgcat acccgggaca 2480881 acattaataa cctttttaaa accttgtttt ttcatggtgc gggccgccat ttcactcctt 2480941 cttcccgaat ggcagataat ataaatttca tcattttcgt ttaattcgtt agcgcgcttt 2481001 tccacttcac caagagggat atgcacaact cctgggatat gagctttttc atattcctct 2481061 atctctcgaa catctaaaat gttaagagac tcgtcactat ctactttctg tttgaaagct 2481121 tctaatgaaa tctcaggaat tgaagatgca ttttctgatg aatgctctcc tccttttcga 2481181 agaaaatgac gaagtatttc tccctctgct tcagtaccca gatattcatg gcctgtactt 2481241 tttgcccatg cttccagatc tgctgtagaa cctttatctg tcgcatgaat ttccaatact 2481301 tcaccagctt ttaaatcctt cattctcttc ttcgttttta cgataggcat tggacacgcc 2481361 aaacctttag cgtctagtac aatagttgct ttcatcattt tttcctcctt ttcttatata 2481421 ggggtggggg tatacaaata tacaaaaagt ttctcactgt aagttaacac catgtattca 2481481 tacccccttt tatatttgtg atgtttttaa atccttgttt cttcaatatt tttacttgcc 2481541 tttaaacttc tcattccgct tagcaatgag taaatgagta acattagata aataagttga 2481601 cactgccttc ctcagcatct gccaaataag ctgctacacc agcatagtca atatcatcta 2481661 atagttcttt ttcctgtaaa ccaagaagat ccattgtcat cgtacaagct acgagcttta 2481721 ccccctgttc ttgagccatc tcaatcaact gaggtaaagt aagtacatta tgctttttca 2481781 tcacattttt aatcatttta gggcccatac ctgcaaagtt cattttagat aaacccatct 2481841 tatcagcacc acgaggcatc atctttccaa acattttttc aagaaatcct tttttcactg 2481901 gaatcagctc ttctttacgt aaagcgttaa atccccaaaa agtatggaag atcgtcactt 2481961 catgatcgta ggcagctgca ccatttgcaa taatataggc tgccattgct ttatcataat 2482021 ccccgctaaa taaaacaatt gttgtgcgtt ttgtttgttc tgtcatgttt attctcctaa 2482081 ctaattaccc ctgcgggtat attaaagtca aaaaattttt tcgaaagatc tgcttttatt 2482141 caactcttta aataccatag ggggtataat ataacgcata taaaaattcg tcaaccttag 2482201 gttgatgaat ttttatcggc tctttaccaa taagtcgact gcttctttta ctaaattttg 2482261 tgtgtcttcg cctttttcta aactttcacg aacacaatgt tcaaggtttg tgctcacaat 2482321 taaacccatc gctcgatcga tcgcattacg ggaagctgct aattgggtca caacctctct 2482381 acaatctttt ccttgttcca tcatagtcaa tacaccttta atttgtcctt caatccgtcg 2482441 taagcggttt ttaatctttt gatcatactc catatatcaa tgaaatcctt tctttcattt 2482501 atttttacat ttacatgttg ccagttcata actgtttaca tggatacctt tgcgctttag 2482561 aaaacgcact cctaaattta attccacccg gtcacgagct attatgtgta ttttatcacg 2482621 tggaatctct aaataaaaac gttttagata cgcatatggg atgtttaaaa taatattatc 2482681 cgaaaaattg gctacatcgt tataatgacg aatatctaat attgtgatgt ccatagcctc 2482741 taatttatct ttatggatac aagagattcc ggttatagga taataacgtc tatacgttgc 2482801 aatgataatc acaaaaataa gcaggaatgc aataactaaa taattgatac tatttacacc 2482861 accttattaa ctctttgttt attcacaaaa caataatata cccccatagg tatatagtca 2482921 agtgtgaaag ttactttctt tgagctgata gattcatttc gatatccgcg gattgaaaaa 2482981 atacttacat tcgataatgc caattctgct aaaaggaact cgaataaagc aataagccga 2483041 tttaatttta aatcggcttt atttatcaat tacttaaaat tagcacaaga cacgctgctt 2483101 ggatattaaa tggggtttca ttagcatggt actggttccc catgtttcat gctggatgtg 2483161 actttaatta ttctagaatt ctccagaata tctgtgctaa tcttccgcag ccactgcatc 2483221 tgctttggtt tcatgaactg taccaaatgg atggttagga ggagcataaa tggagtaaag 2483281 ttttaatggc gtatttcctg tattaattac gttgtgccaa gtgccggcag ggacaacaat 2483341 ggcagaatca tcatagacat ttctttgaaa gttcaaatga tctttgctct ttcccatttt 2483401 gacgatccca cgcccctgct caatccgtaa gaactggtca acgttaggat ggatttccaa 2483461 accaatgtct tctccaatac caagactcat caaagtaact tgaaaatgct ttcctgtcca 2483521 taaagcagta cggaacgtat tgttttgttt tgtggctcta ttgatattta caacaaatgg 2483581 ttttggtcca taatccttca aaagaaggtt tctatcttca tatgaagagc gcaaatcggc 2483641 acctctgtgt actttctcca tctcatttgg aatagtccaa taaacagatc ttccatcatt 2483701 atacatcggc acagtcacat aataataaca ttgaggcgaa aaagggttat agtacatttt 2483761 ttgatccccg caattataaa tttttgtgat agtatcctat gcatttatta agggagtgtg 2483821 ctaaatcaag aaaactcata ttaaacacaa aaatgaatgt tcgatcaccg tttgattcat 2483881 ggatgaataa tttatcaccg accttgtaat cgttttctag atgttgaatt tcactagcct 2483941 ttgttaacaa gacatcgaat gacaccttta tatgatggat tatcaaaggt cgacgatcct 2484001 aaatggcttt tgaacattta catagcacaa caacagagta tacggaattc tgttgtttgt 2484061 cccccctatc ccagctcttt tagatttatc tctttggatg cgccttgatg gccagttttt 2484121 cagcagcata gaatttatcc cctcctgaat cgttatagca tatttcaacg ccgatagact 2484181 tgcggttccc agtgccgttt gtaccgtctc ctgtatgtgg gctcgctttt agtaaaccag 2484241 tttatattct ttttgggcac acaacagaaa caattttcca tatgaaaatc tcgtaatttt 2484301 acacctcttt aacttgaagg aggatttttg catatgtatt ttcatacccg tcaactacca 2484361 tctcatccag catatattcc tcatatgcat tttcccctat ttgcattcca tttctttcaa 2484421 tgaactcaat gattctccgg tacgcctctt cagtatttcc gcctatttca tatccaactg 2484481 catacaggcc ttttggccgt acatgataat ttatgttctc tgccccatct tttactttta 2484541 tataaaagta actgtaattg tagaagtctt tttctaagat ttgttcccgt gcaaagattc 2484601 cgcctatcgg atatccttca tctaattcat attgctgaac ttcatgaatg agttctgaaa 2484661 tggctgccac atattttcgt tctggtaagt ttaatgtttt tcggcttaac atgaatgttt 2484721 cttcatttaa atattcaaaa gaaattgagg aaaaatcagt ctcaagtgct tgttctgtaa 2484781 gcgtcacttt tgtttgtaag atcgtttgca actgcttaag ctcatttatt tttttatcaa 2484841 tctcaataga cttttctttt agaacatgca ggatcttgtc tggtgttttt ccttttatta 2484901 gacactttat ttcttttaat ggaaccccaa gctctttaaa tagactgatg acttgaaaag 2484961 tctcaaattg atgataggaa taatatctat acccattttc tttttttatt tccggcgaga 2485021 aaagaccaat ctcatcataa tgaaataaag tttgtttttt tacacggcag agcttcgaaa 2485081 actcccctgt tgtgaaatac ttcttaacat cttcgctcat aaaaacctcc ttgactatac 2485141 ggtaaccata taccttatga tttgattgta cttgaaaaaa gcttcaagcg aaaaggatag 2485201 gtaaaaaggg ttcaattgag taaaagggga attcagatga aaaaatcaat aaatgagcaa 2485261 aaaacgatat tcattatact attaagcaac atcttcgtag catttcttgg tatcggttta 2485321 atcattccag ttatgccttc ttttatgaaa atcatgcatt tatccggcag cacaatgggt 2485381 tatcttgttg cggcttttgc catttctcag ttaattactt caccttttgc aggtaggtgg 2485441 gttgaccgtt tcgggagaaa aaaaatgatt attctcgggt tgcttatatt cagtttatct 2485501 gagttgattt tcggattagg gacccatgtt tcaatatttt atttctcgag gatattgggt 2485561 ggtgtaagtg cggcttttat catgcccgcg gtaacagcat atgtagctga tattacaacc 2485621 ctaaaggaaa ggtcaaaggc tatggggtat gtttctgctg caattagcac cggctttatt 2485681 attggacctg gtgcgggagg atttattgcc ggctttggta tccgcatgcc gtttttcttc 2485741 gcctccgcca tcgcgttaat agcagctgtc acttccgttt ttatactaaa agagtcattg 2485801 tcgatagaag aacgccatca actctcatct catacaaagg aatcaaattt cattaaagac 2485861 ttgaagagat ccattcatcc tgtctatttc attgcattta ttatcgtctt tgtaatggct 2485921 tttggtttat cagcttatga aacggtattc agcttgtttt ctgatcataa atttggcttc 2485981 acaccaaaag atattgcagc cattattacg attagttcca ttgttgcggt agttattcaa 2486041 gttttactat tcgggaaatt ggtcaacaaa cttggagaga aaagaatgat tcagctgtgc 2486101 ttaataaccg gtgcgatctt ggctttcgtg tctactgtta tgtcaggatt tttaactgtt 2486161 ttgcttgtaa cttgttttat ttttctggcg ttcgatttgc tacgtccggc cttaaccgct 2486221 catttatcca atatggccgg taaccagcag ggtttcgtag caggcatgaa ctccacatac 2486281 accagcctgg gaaatatatt tggacctgct ctaggcggta tactatttga tcttaacatt 2486341 cattatcctt tcctttttgc aggtttcgtt atgattgtcg gccttggtct tacaatggtt 2486401 tggaaagaaa aaaagaatga tgctgcagct ttgaattaat tcattttcta taaagttaag 2486461 tcatttggat gcagggaatg cccctggtta ggcacaataa gaaaaggtac ttaatttgat 2486521 aggctacatg ttgcttgacg tgaatatagt ataagctgag ttttagcaat atcaggatac 2486581 cgggataaga aaaaaggaga atgtagtatg agtataaaca taaaagcagt aactgatgat 2486641 aatcgtgctg caattcttga tctacatgtc agccagaatc aattatcata tattgaatct 2486701 acaaaagtat gtttagaaga tgcaaaagaa tgtcactatt ataaacctgt cgggctttac 2486761 tatgaaggag atctagtcgg ttttgcaatg tatggattgt ttcccgagta tgatgaagat 2486821 aataaaaacg gacgagtctg gcttgaccga ttttttattg acgaacgcta tcagggaaaa 2486881 ggattaggga agaaaatgct taaagccctc attcagcacc ttgctgagtt atataaatgc 2486941 aagagaattt atttaagtat atttgaaaat aatattcatg ctatacgcct ttatcaaagg 2487001 tttggttttc aatttaatgg tgaactcgac tttaatggtg agaaggtaat ggtaaaagag 2487061 ctatagatat ccaagcctcc ttgtttgctg agaaacgttt gaacttcgat aatgattacc 2487121 tacttaaact gcaagatcat tgtttaaaaa agcctggatg aaaatttcat ctcaggcttt 2487181 aagcatctta ttagtcaaaa tctcatgtgt tttatccaga tgttattctt ttttccggac 2487241 aatttctaaa taattaatat gccggccaac tgtttcgtgc actttaaaaa tatacccatc 2487301 ggcttctata acggacccaa ctgcagcgtc tatttgttga gtcataaacc agccgcctat 2487361 tgtatccact tcgtcacttg ctaacgtcgt tcccaataaa tcatttacat cttcaatgag 2487421 cactttcgaa tctaagatat agtgattatc atttactttt ctaatattag gcacttcatc 2487481 tttatcaaat tcatctctga tttccccgac aatttcttca agaatatctt cagcagtgac 2487541 taaacctgaa gtgccgccat attcatccac aagaatagcg atatgtgttc gctctttttg 2487601 catttttacc aatacatcat gaattggaac ggattcaata acatggataa cagggttgat 2487661 atgattttct aacttgaaat cctcttttat cttctggtct gtgtcaatat aagctgacaa 2487721 aaattcttta gcattgataa aaccaatgat tgaatcttta tctccattta ggactgggta 2487781 ccttgtatag ctctctgtct taatgatctt aacaatagtt tcataagaat cctcactaga 2487841 aatcgctacg atctctcttc tcggaatcat aatttctttg gcgattcttt catcaaattc 2487901 aaaaatatta tttacatatt tcaactcatt ttgattgatt tcaccgctct tatagctttc 2487961 agacagtaag atgcgcagtt cttcttcaga atgagcaagt tcatgttctg atgcaggttt 2488021 caaaccgaag agtcctacta taaaccgggc tgaaccattt aaaaaccata taaaagggaa 2488081 caggatgcgg taaaaccaaa taattggctt tgcagtcaaa agagtgatgg tttccgcttt 2488141 ttggatagcg agtgttttag gagcaagctc tccaactaca acgtgcaaaa aagtcgccat 2488201 cacaaaagca atcactaaga tcaatacatg tgagactgtt tcacttacat gaaaatgagc 2488261 aaataagggg tgcaaaatca cttcaaaagt cgattctccg acccagccaa ttcccaacgc 2488321 tgtaaccgtg atccctaatt gacaagctga caaatattcg tccaaatgag taatgacctt 2488381 tttggctgat atggcacctt tttttccctc taatatgagt tggtcaattt ttgatgacct 2488441 gatctttact atcgcaaatt cagtcgcaac aaaaaatgct gttaagacaa ttaaaagagt 2488501 aaagattata aggttaatgg ttgtcaatga tttgccttac ctagtaaggc gtacacctcc 2488561 gatgtaaata tttattgaat aaacaaaaaa cagtatatat aacattataa gttcaaaaga 2488621 acctaaaatc aactctgaat gatgtaaata atcatctttt tccgtatgga gagtggttcc 2488681 catagtcttc aactaacgat tagtggcgtt ttaaggctta aaaaagaaag caaaataaaa 2488741 acacacctga attttctggt gtgtttcaat aatacccaac cgtcttgatt tatttaatgt 2488801 ctttataaag attttctttt aaaatttgaa tcaattcggc ctgttgcttt atatttttgc 2488861 ggccatttct attaattgca gcaagttcac agacaattcc agctgaaatg aaaaacaata 2488921 aaccttcaaa cattttaaat cccccactgt ctaagtgata gtcaaatttg ttttttcttt 2488981 ttgcaatacc tgcttataat cttccttacg ctgatatatg ttatttaaaa tgagtccaat 2489041 aatgacaaac agtgttccta ctatatcaaa agcagttatg ttatatcctt tgatcaccat 2489101 gattaacaat gtagtaatgg ggacaaagtt aataaataaa atcccattaa tggatgatag 2489161 gattttaatg ccatagttcc aactaaggag ggctatgata cctggtaaag taatcataaa 2489221 taaaaaatca tacttaattg ctgcaatcac tttaatactc ggtaccgaca cgtaaccttg 2489281 cgcggtaagt atagctgtca tgattcctgt tatagctgtg ccgaataaac atgtcaaagt 2489341 tgaataacga agtgtggacc actctcggaa tatctgtccc cccattgtgt agacaaccca 2489401 ccctaaaaca ccaatgaata taaagagtat cgagaataga tgatccccta atgaaaaaaa 2489461 gaaacttata ttacctttgg ttatgaccat cgaagccccc aaaaaggcaa tcaatatact 2489521 gatcattgtg tattttttag gtttcacatg tttatatccc catagaataa caattgaaag 2489581 catcggcatg agtgcctcgg caatggatgc tgtcataatt ccagacttcc ccatcaacct 2489641 ttgacctaaa aaaataagaa cattgtatat agtaaacgcc atcaccccaa ataaaatgat 2489701 ccattttgct ttaccctcta aatgaaatga tttctttcct tctctcacca ataataaaat 2489761 cactaacata atcgttacca caccgtagcg aataaatgaa aaataaaacg gatcaacaaa 2489821 ttctaatgca tgatctgcaa ctggaaacat cgcgccccaa gacatacttg ctactaaaca 2489881 tgtaagggca ccaatgaata attgaccttt tttcattgaa ttcccctcct tttctttaaa 2489941 attacaatga gaattataaa aagaagtaag catcaagtaa aatgaacaaa agtgatgaaa 2490001 aacatcattg ataatgatac tttaatgaag gggggatctt catggaactg cgagacttac 2490061 aaattttcaa atgcgtagcc catcacaaga gtattaccgg tgctgcaaaa gagttaaatt 2490121 atgtacaatc taatgtaact gcgcggatta agcaattaga gaatgagctc aaaacacctc 2490181 ttttcaatcg ccataaaaaa ggggtttcac taagcccaga gggccgaaaa atgattgaat 2490241 acgttaacaa aattttgaaa gatgttgaag aactggagca agtctttcta gatactgaaa 2490301 taccgtctgg aatattaaaa atcggtacag tggaaacagt gaggatactg ccgaccatca 2490361 tagcttccta ttataaaaag tatcctaatg tggatttatc attgcaggct ggtctaacag 2490421 aggaacttat taaaaaggtc atgaatcacg aattagacgg agcttttatt tcaggcccct 2490481 tgaaacattc tattctggaa cagtatgatg tttatactga aaaacttact cttgtaacca 2490541 gtaacaaaac gtttaatata gaggattttt caacgactcc gattcttgtt tttaaccagg 2490601 ggtgcgggta tcggtctagg cttgaacaat ggctcaaaga tgaaggtgtg ctcccaaaca 2490661 gaatgatgga atttaacatc ctagagacaa tcttaaatag tgttgcactt ggactcggta 2490721 taacagtggt accggaatct gctgttatgc atctagctgt acaaggtaag gtttattgcc 2490781 acccattgcc tgagaaagac agctgtatct caacaatttt tatacgccat aaagatgcgt 2490841 acctgacaaa ttcaatgcgc agcctcctaa agaccattgt tgaacataaa aatatgagta 2490901 tggcttaaag tgatttttct ctttctatat tctaacttct taaataaaag agaaggctca 2490961 tctccacttc gctaccctta ttcacgcaaa aaatagagca gtaaacatgt gagttactgc 2491021 tctgcttcgt ttattcaccg ttcatttgtt ttacaatgta ttcagcatca tttcctacgc 2491081 cttgaagcaa cgctgaacct cgcttatgct gccaaggcaa acctataaag tacaatcctt 2491141 ctacaggtga aacacctcta tgatgtatga ttcgaccttc ttgatccaaa acacctttta 2491201 tatttatcca acataaggga ttcctgaaac cagtagccca aataatattg tttacttcta 2491261 atgtagatga atctttaaaa atgatttcat tttgctttgc ggcaatgact ctttttttta 2491321 agatgatctc cttctgtttt attgcatgtt ttaattcatg cccaaatact ggatcacctt 2491381 tcttttgaat gaatttgcct actattgatg tatgacttgc atgtaaaact cctagtttat 2491441 caaaccacca aaagatgctt ctttttccga tcattaaagg gaaataaaca agtttattac 2491501 tacaagctaa atatgtaact ctttctttgg ataattcaac agctatttga gcaccactat 2491561 tcccaccacc aactactagt acatttccat atgccaattg ttttgaattc ttatattgtg 2491621 atgagtgtag ttgattaata ttatcggata aatcctttga tattgatgga atattagggg 2491681 tatgaaaagg ccctgtagca atgacaagat tcttcgtttg atattcttcc cgatttgttt 2491741 ttattaagaa ataattcttt atttttagga cacttattac ttctgtccgt aattggattg 2491801 gaatttcaaa ttttttaaca tacttcttta gataagcaac aatttcattt tttgaaggaa 2491861 atccatgttt ttctccttca agatgcattc caggcaaaga gctatacatt cgagaagtaa 2491921 ataaaactaa tgagtcatac cgatctttcc agctctcccc cacctcatga cttttatcca 2491981 aaatgataaa cttttgatcg gactgcttaa gataatatcc tattgagatc cctgcttgac 2492041 cagccccgat tactatagtg tcgtacacat tatcaccccg ccaatttcaa attgtcagta 2492101 gacagaatct gcaaaatcct agttgatctc ctcactataa agttagataa aaaatttaat 2492161 ggtgatggtg gtcacgctgc ttctccattt tgggctgaca aaggatcgca ttgtcgtggt 2492221 tatgcgcttc ggtttccatt tgaatggtta cgtgcgtaat gcctttatgc tcaagttcat 2492281 gttcaatttt gcgtaaaata ttttcacttt ctgaaatggt cagttgatcg tcaacaactg 2492341 cgtggcaaga aagagcattc aatccgcttg tgatagacca tatgtgtaaa tcatgaatgt 2492401 tttgaattcc ctctgtccct tcaattgtac gaatgatatc agagacatcg atattttctg 2492461 gagttccttc cattaagatg tgaatggaat ctttagtcac attgtaaccg cttcttagaa 2492521 caagaatagc cacaatgata ctagccaatg gatctgccca gccccatcca aagaagatga 2492581 taagtatggc agctaaaatg gcacctacag agccgagcat atcgcttatt acatgtaaat 2492641 aagctcctct tatattcaga ttattctttg tatctccgcc actcatcata atccaagcga 2492701 ccaatagatt cacaactaac ccgatgatac taattgtaag catgccggtt gttgctactt 2492761 ttggtggatt agagaagcgt tcgattgctt cataaatgat ataaagagaa ataagaatta 2492821 aggcagcacc gtttatcaca gctgcaagaa tctcaaatcg tttatagccg aatgtcttat 2492881 tgtgatttgc ctttttttca gctaatgtaa aagcaatcag ggcaaccatt aatgaaattg 2492941 aatcactcag catatggcct gcatcagata aaagcgccag gctatttgtt aaaaatccac 2493001 ctatagcttc tataatcata taacctgtaa tcatgataaa agagatcaat aaaacctttt 2493061 tatttgctcc ttcattatga ttgtgaccca taaaaaactc ctccttacct aaagttttta 2493121 atacatatgt atttattatt tcaaatctgt tatgaagcat tctaacatga tacaaataat 2493181 atttatatat gagcatgtgt tcatatataa atatatctgc tctttactga aatgtcaaaa 2493241 tatttttata gaaatccaca atacctcctt aattattctt ttataaacat aaaaaagcgg 2493301 agcaaacaca tggtttgctc cgctacccta gtttctctat ccttttcttc aatcaagcat 2493361 ttgagggtag tattcaacta caatttacct gttaaaaatt gggcctcacc aagtccaaaa 2493421 ctccagtcag cattatcatt ttcaacaata gatacaatta aatcagttga tgcgatacca 2493481 cactcagatt ccagtctttc agctaacagc ctgtaaaatt tttgtttctt ctcttccggt 2493541 cgggatttac ttgtaactga aagaacaaca agatttttag ttcggttaaa tcctaaccca 2493601 gtatcctcaa taatcatatg attttctgga tgttcatgaa caatttgata acggtcttgt 2493661 tgaggcacat caaaagcctc tactacaaca ttgtgagcga catctaaaag ttttttcaaa 2493721 cttgattgat ctcgcccttc tattaagtca aaacgaagta atggcataaa atcccctcct 2493781 tctactacaa cagtcttttt aatttcattc gttaatgtgt cagctatttc caagcagctg 2493841 ctacatttag aaaataaagt aatttcccaa taaccccttc attctggtgt tagtcaagcc 2493901 tatgttatga tgtgtatttc cataggcaat atacagaatc aacttcgagt aattaaccat 2493961 tttttgaaat agctttatca cttactttag aaatcattta ttcttctaag ctttagttta 2494021 catgaagctc tgctatcata tataattcaa aattaagatg gaagacatct caaaatcaga 2494081 tatcaactat ggaggactag atgaatattc agttgttaca ggtttttctc actactgctc 2494141 gtgaaggcag tatttccaag gctgctctga ctttaaatta tgcacaatcg aatgtaacga 2494201 ataagataca acaactagaa aacgatttac agacaaaatt attctatcgt catagtcgag 2494261 gaatcacact tactccccca gggcaaattc ttgtttctta ctcagagaaa attctacata 2494321 ctattgaaga agctagagca gccatgggcg aatcatccgc gccttctggg ccactgcgta 2494381 taggatcaat ggaaacaaca gctgcagttt ggcttcctca actccttgca cattataata 2494441 acctctatcc aaatgttgat ttgaacctag taaccggccc tacggaacaa caaatacaag 2494501 cagttttaca ttatgagtta aacggcgctt ttatttcagg gcctattgaa caccctgatt 2494561 tagttcaaga aaaggtattg gatgaagaga tggttcttgt tacaagtgct tcacaccctg 2494621 tgatttcttc cattcaggat gttcaaacac aaacaatgct tgtattccgt aaaggatgct 2494681 catacagagc aaagctcaat catatcctgc aagaagaagg tttattacct ataaaattaa 2494741 tggaatttgg catacttgaa gcgatcattg gctgtgtaag cgccggcttg gggatttcac 2494801 tgctgcctcg ttcaatcatt gcttcgcatg aaaaagaagg ccgcatccgc agccacacta 2494861 tctctgacaa atattctttt gtatcaacta tgtttataag gcggaaagac actttaatta 2494921 cccctgcttt atctgctttt ttaacgcata tgagggatca ttttcagata aagaggccag 2494981 atcaatcgta aataaatgga tggaaggcat gcttcgcctc aaaatacccc tgatcagttg 2495041 tctgatataa aaatataggc gcatctcaat gtttgtatag agcaaaaaag caaacttcgg 2495101 tatgtagttt gctttttctt cgtgattttg cactctgaat cgtgaaacct agtcgatatt 2495161 aggatgtaga ttttcctcat tcaaagaatt ttgaacgaag gtcattgccc tagacacttg 2495221 gttgcgtctt gaagttaaag gctgactatt tcctaaagcg tcaatcgctc tcacaactat 2495281 taaatattca cctacagatt tcgggtgaca acgggaagat tgatattttc ggttggacag 2495341 gggcagaaca tccaattgta acagttgaag tatccactga tggaggagat cctgcagatc 2495401 tgagtgatat tgctgttgat tgatcaactt gtttttgttc ggaatatact cagtatatag 2495461 ccgcatattc ctcctgcaat agctggaatg agccacccca gccctatgtt atacatagga 2495521 agaatctgag tgaaaatacg attcacaact tcaattttta ttccagccgc cttcaaaccg 2495581 tcaaataggc tgatgatgaa tgcgaataat aaactgcctt gatacacttc tgtcttccct 2495641 ttaaatacag aatgcaaaaa cgttaaaaat attaaggaaa tcgcgatagg atacatcgtc 2495701 agtaagacag gcattgacac cttaatgagc tgggttaatc ctatatttgc gacaagcgta 2495761 ctaaacactg ataaaacgac agcaattttt ttataagaaa tgttcggaaa taattcatga 2495821 aaaaatgaag aacacgctgt gatcagcccg acacttgtcg tcagacacgc cactgtaatc 2495881 attaagccca ataagattga accataagat ccaaaataat aggatgaaac cttagccaaa 2495941 acctctgctc cattttctaa aatccccagt tcttcaacgc tggaagcccc catataggaa 2496001 agggctgtat acataactgc taagagtaca gctgcaatcg cggctgcttt tgcacaaaca 2496061 actatcagct gttttttggt agaagctcct tgttctttca atgcattcac gatgataatt 2496121 ccaaaaacaa atgctacaag ggcatccaga gtgaggtatc cttcctgaaa tcctttaaaa 2496181 aacgcttgtg atgtgtaccc ttttgatggt gcttgaatgg ttccaattgg gcgaataaga 2496241 gctacggcta caagcaatcc gataaatgtc agcttaattg gcgtcaaaaa tttaccaact 2496301 atatcaatga tttttgaagg attgagtgat aacaagcatg ccaatgcgaa aaataatatt 2496361 gtaaatatga tcaatgagac agggcttgca tcatttgata aaaaaggttt taccccaatt 2496421 tcaaacgata cgtttcctga tctcgggata gcgaaaaaag gcccgattgc caaatagaga 2496481 atcgtcgtaa atacaatgcc aaacaccggg tgaacacggc tggctaacga ctgtaagttt 2496541 tgtttacccg aaaaaacaaa tgctgttata gccagtaatg gcaatccaac tccggtcact 2496601 aagaaacctg cattagcgac ccatacattt ttcccggcca attgaccaag cataggcgga 2496661 aaaatgagat ttcctgctcc aaaaaacaat gcaaatagca ttaatcctat aatgatgata 2496721 taggaagcag acactttttt tgacattata tatcctccga ttaaagtaga cacttcttga 2496781 atagccagga aacattacag atgctatttg cactggcaca gtgttgattc caaaataagc 2496841 ttgtgtcagt tttatatatt tttatcaagt taaataaaag catgatcatt ttgatcgttt 2496901 ccgatatcgg ttaaaaaacc aattgcacca aaaccatata aacaacggtt ccccccgcta 2496961 tggaaagaag catatttttc ttccacaagt gaagcagtac aacagcagct gctccaacca 2497021 attcaggaat gccatgactt ccagaaagta gactcacatc tttcaaacaa taaatgacta 2497081 aaagcccgat taccgctgat ggcagcactt taccaagata ctgtacatat ttcggtgtcg 2497141 gtttgccaga cgggaaaatc atgaatggaa ggaaccgtgt cagcattgtt ccaagcacga 2497201 ccattgcgat ggtgatcatt tgctgcgtca tagtcatcgt catacggaaa cctcagcttt 2497261 ctccaatggt tttctcagaa cagtcagtac ccctaaaatg gcgagcatag caggaataat 2497321 aaattggttt ccgccaaaaa ggataagact ggctactgaa agtccaagtc ccgtgagagc 2497381 actgtaatgc tttttctctt tcatccattg ttctatgaat atcacaataa acagagcagt 2497441 catcacaaaa tcaagccctt cggtattaaa cttcacgtac gacccaaaaa tacctcctat 2497501 cgctgccccc gcgacccaat ataaatgatt aagcagtgtc acaaaaaaca taaaccagcc 2497561 cttatcaaca ttcgccggaa cattagcggt ataattgata gaaaatgatt catcgcacat 2497621 tccgaaaatc agataaagct ttttctttcc agtccccctg tacttatcca acatggaaat 2497681 tccataaaac aaatgccggg cattgaccat taacgtcaaa aaaagagcat tcatagggtt 2497741 gaacgcacca agtaaaaaat tcgctgcaac aaactccatt gagcccgcaa atatcataaa 2497801 actcatgatg attggataga ttgcgctaaa tcccaaagaa tgcataaaga tcccataagc 2497861 tatccccaaa aataaaaacc ccgcaaaaat cggaatggta tatgggaatg cagaacgaaa 2497921 tgcagcccat atttgacttc tcttattcat atgagtgttt atagcaggag agcttaaatg 2497981 taacgattct ttatttttat tcaaatcaac aacctcctac atttcatcaa ttggcacact 2498041 gacagttctt ttttctgtac tcatgactat gcttgtgtca actccactaa tagcagggtt 2498101 ctgcattaat gaatcaatga taaaattccg ataactctcc atgtccttcg ccacaatctt 2498161 aagcatatag tcatggcttc ctgtaagtgt gtagcattct tgaacctgtg ggaatttgtt 2498221 tatatcctct aaaaatgaat gaattgtctc cctatttaag ggtgataagt tgatgagagc 2498281 tagtgctgtg acttcgattc caagtttttt ctcatcaaca atagtcgtaa actttttaat 2498341 tatacctgct tctactaggt tctttgttct tgcaaggcaa gctgatggtg aaagcccaat 2498401 tttcttagat aaatttaaat ttgatattga agcatcttcc tgcaaatctc ttaagatggc 2498461 cttatcagtt tcgtcaagca taatacccat ttcacaaccc ccaatacaac ttaacagaat 2498521 tatatttcat acaatttaaa taataacgaa tttttattcg ttaatcaaat attatttaaa 2498581 tttaaatcct tttaaagtat tattcacaga ataaaattat cctcgcgatt aactcataat 2498641 gaaattaact tacatcagaa agaagtcatg ggagagttat gtacttgtgt gacttgatac 2498701 caacatcata agaaacttat cagaagccaa aaagttattg cggtctcacc gaaaattgaa 2498761 tttgcggtgc cctattgcct ttttccgcga acgaaaattg ttaaaattcg caaaacagaa 2498821 agtctactct attattattt taaattcgtc ctttagttct tcttgagcct cttgtataac 2498881 ttctaataca tcgtcagcgt atgaacctaa aaatgtattg ctgaactcaa aatttttcaa 2498941 gactaaagtg agcggcaaat ccacccaccc tgtcaggcaa tcccataaag cgtctaaatt 2499001 tctcccatag tagtctggga agtctagttt atcttttaaa tcatcatgta aaacttctat 2499061 attttcaaag tctcttccat ctattattat ttttctcatt agaaactatg ccctccatta 2499121 ttttatctta acaaacgttt actatgtaac agctgtttgt ccaaatgagg ctgaaaacaa 2499181 ataaaaaaca ccgataggat gaaactattg gtgtttgcaa gacatcttca tacccggtag 2499241 gcataaataa tgctaaactt tgtttttaaa aagctatcat atcaaatttt tatgttacag 2499301 cttttactat cgtttaatct aattgaggag taaaacaaga tatgtttgaa aatcacatat 2499361 cccctaaaaa ttaaaaacta atcggcagtt cttcgagtgc tctcatcaga aaattccctt 2499421 tccatttcat ttgtttcttt tcgcctttta actgtatatt tggacagcgg cgtaataagg 2499481 tggaaatcgc aatctttgct tctaagcggg ctagctgtgc accaagacaa aaatgattgc 2499541 catggccaaa agcaatatgg cggttgttct ttctttcaat atcaaatatg tcggcatttg 2499601 gaaatatctt ttcatcacgg tttgctgatg ctaaagaaat gatgatcaca tctttccgtt 2499661 taatctcctg cccatgcagt ataaacggtt cagccgtcca gcgaattgtc gttagctcaa 2499721 cagggctgtg aaaccgcaat gcttcttcta tggctgaatt catcaagtcc ggctgctggc 2499781 ggagcttttc tagttgatca tggtgacaca tcagagcata tgtcatattg gtgattaagt 2499841 ttacggttgt ttcatgacct gcaacgataa gcagcataat catcgagtac aattcttctg 2499901 tacttaattg tgtgccttca ctttccgctt gaattaatgc actgattaaa tctcctgcag 2499961 gttctctcct ttttttgcga actaaggatt ccagatattc aacaaactcc cctaacaagt 2500021 ggtcattctc ctgaagtctt tcaggggcat ctgaaaaatc aataattgct tgcgaccata 2500081 ctctgaattt ttgacgatct tccaagggaa tgccgagcat ttcacttatc acgataatcg 2500141 gcaatggaaa cgcataatcg tctactaggt tcatgaattt gttgggctgc actttatcca 2500201 ataaagaatc tgcgatatgc tggattttgt cttccaactg caaaatcatc cgatgcgtaa 2500261 atgctttttg aacaagagtt cgcaagcggt tgtgatcagg gggatctgaa ttaagcatat 2500321 gttttgttaa agtctcttca ttcttcaata gagcaggacg tttttctttt gcggtaaata 2500381 cattttcata gtttttcttt aatttttcat tctttaataa atgtattgca tcatcatatc 2500441 tcgatatgag ccagcctttc cccagagctc ctaaagataa tgggtagaga gcctgtgatt 2500501 ttcgcaattc tttataaaat tcatacgctt catctttaaa tgctctcgaa gacaattgac 2500561 tttccgtcaa aatggttaca ctcttttttt cttttgaaga cattcattcg acctccatct 2500621 ttgaaaggtt atgataatct ttaaatataa aatcaggacg atttgtaaaa tgatccattg 2500681 agatcagtat tcatgataag ggccaaaatg ccgtccccgc attttgaaat aaaagatatg 2500741 agacagtcat taatcatttt gctgcctaaa ctctttccct gataaaatgg cgaaactcct 2500801 aatacttcta tgccggctct tttaaggatt tggaaaattt tttagcccca ttttgattaa 2500861 tgttatcccc cctgctgcta tataatcgat caagtttaat gtcgggttta tcacgatgtt 2500921 ttaatagagc ggcaacaacc atttcaccat tctgaatgcc aacaaaaaag aaatgctttt 2500981 taaaatatgc tcttgtcagt actttatgca tttcaaaaat aaatgaatga tctttttttc 2501041 gcgttttacg agtaaatcca taaaaggata ttgattgaaa gattgatgga atagctttgc 2501101 cactttgctt acttcatctg ctcttgcttg tcgataaaga aacattgatg cacctcctct 2501161 gagcagtaaa gcaggaaatc gaattaaagc gcccttccta ttggaaaggc gcctgccgtt 2501221 ttactgtgcc aaaatgtttt tcatcagtga gtttttataa aatcatttat taattgatca 2501281 gttgtcaata ttgtggcaaa ttcatcatgc aatgtagcta gagatatatt atgaatagtc 2501341 gccgcatcat aatatgtatc attttggtct ctcattccga aggctgctgt tgcatctgaa 2501401 atcaggtatg tatcaaaccc taaattacca ctcattcttg tggtggttga tacacagtga 2501461 ggcgtggtta aaccagttat gactacagtg gttatttcat ttaattttaa gaattcttct 2501521 aaattcgtac caataaagct gctatttact gtcttggtta taatgacttc ttcatccata 2501581 ggcttaacta tttcctttat tgcaaaccct tcattctttg gatggaataa agaatgaggt 2501641 ttatcagaag tgtgttgtat gtatatgact gtccatcctt tttctctcca taattctagt 2501701 attttactaa tgttttcttc cgcctttacg ttattccgtt ccccccattt tttatcatcg 2501761 aaggcttttt gtacatccac aatgattaaa gctttctttt cttccacaag ataccctcct 2501821 acgtagaatt tctatttatt actacattct aaatacaaat tttacttttg tacaattgtt 2501881 taatgatgaa tttcaaatga gcgccttctt tattggaaaa tgcgttctat actgcaactg 2501941 tgcccaagcc gttaaccttc aaatctaatc tgagaatcac tggctctaca gagaataata 2502001 aaaaacactc taataacgag tgctgaaatg aaaaactatt gatttagaag ccatttgata 2502061 cgctcagctg aaatgatgta gtggagtatt ataagacata aaaagacaat actaactggt 2502121 tttaaataac taaaataaag cgctgcaaca gccattgcaa agatcaataa ttcaataact 2502181 aaccttgtta ctccgtttac agctattaca gtttgtccgc ttcgactagg atcatgaggt 2502241 actgcaaata cagaccagac aatcataact gcaataggta aaaccaaagt taaaacatat 2502301 ttaaaataac cattaaagct tatccaagca tacaccccta aggagattag tgcagcaatt 2502361 tcaagggtga atcttaaaag taaattagtc tgattcagtt tttccaactc ctctataaaa 2502421 aacacccccg caggagatgc tctttctctg ctttatttca gcgtataaaa acttttctgt 2502481 tcttcctctt tagattctat tgtagttttc ggcgagatta cctctacttt tgaagagatg 2502541 ataccgactg ctgctgttac caatgctccg ataatagaac gatgataagt ataatgaaat 2502601 atgacaactt ttcccctcct attcagttaa ttatccaaat aatcaggaag ttgtctacaa 2502661 tttgcagaat ttgtcgaacg aagtaaagat tatacctggg aggctttact cattgtatga 2502721 attacagtaa ataaattgcc ttcccttttg agaagacgtt ccaactcagc tagactcttc 2502781 caataggctt ccttttggcg cagctgcttt tattcaaaaa ttgagcaaca cctgaatgtt 2502841 tcattggaat ttctgaacca tcgatcgctg ctgaatttgt tgcaaatgca tacgtaggag 2502901 tagtcgaatg gtggttgaaa aatgaaatgc cttccccacc tcgagtgatg gcagaaaaag 2502961 cgggggtttt gttagagagg aatctataga tatgtgtatc gaagatttga cagcattaaa 2503021 aattatactt acatcgttgg gaacaggcca acaataaagc ggaagaacgt tgtcatttga 2503081 agtggtttgg aataaaaatg attcgaatat gttcttatca ttgtaaacga acaaaaaaag 2503141 aacatgtttt gaaaaaagat tgatcaaaac atcttcttat atgttgtcat agcgtaactt 2503201 tttataaaaa ggttaattac attttcgggg cttccaaacc aaattttgcc cattcttctt 2503261 ttgctggacc ataaatacct ggaacagtta aacctgcttg tctcataaga acagtcattt 2503321 gtccccgatg gtggttttga tgttgaatta aaaacatcaa aagtgaaccg ttaggcattt 2503381 gttgtccaat aaagttgata cgttcttgaa gtgtatggtc agtccattgg gtttttaatg 2503441 cctgtacaaa tgcattactg gcttgatgat agctgtcagc tataaactga gcagaagttg 2503501 gaacaggata atcttcagct ggggcttgga acgttaagtc tgtgtttgag gtaatgatgc 2503561 caatggcagc aacagtatgc caagcaatac ggcctagagt ccaattttgt gaagttattt 2503621 cttgtttaag tgattcatca gtcagactat ttaatagttt ctgtgtagca tctgcttcga 2503681 actcccaaga tttcaaaaaa tggtctaagg tttgaaacac aaaaatcctc cttttcattc 2503741 ttttgttttt tcaatgtgct tataggttaa ttataatgcc tcctttcgtt aaaaagaaca 2503801 aaaatttcgg acaagaataa tcatagtaaa atgcgtagac attcttaaac gtaacgattt 2503861 acgcatcttt ttacaaacat ctgactactt ggtctccatt gtcagcgaga atcaaatatc 2503921 atatgaagac aatcctatat tcttatcact ttactgagca ataaatacct tccgtatact 2503981 tagtaatacc ttcatcgtaa tcaggatact tatatgcaag accttctgat acagcttttg 2504041 aatactttct aaataatgca tagcaagtaa ataaagactt ccacatttcc tgatacccat 2504101 tcacagaata tgtagacatg agttcctccc attctttatt tgaaaggtac cgcttcataa 2504161 atttatagtt cttccccata ctaaatgaat accctttctg agatgcgata tgccaggcca 2504221 tcattctcaa taaattagga cgtacaattt catttaaatg gtcaatggca aaaaggattt 2504281 catttcttgc tagtcctttt actacgtaag tcgaaaccat ccagaactca ttacagcaat 2504341 catcaaattc ccttgcagtc ggccttttta tccagtattg gcgatcattt ggggtcactt 2504401 tatagttgat gaacgaatcc ttatcaagca ataccttaac caaaccatcg ttattagcaa 2504461 aataatcttc tgcttcacga attggaataa gggttagatc taatttgttg ccatcctcaa 2504521 aaagaataat gtatgaaaac caattaccta attcgggagg aaaaagctcc atatcttctg 2504581 gtttttgcat cataatgcgc ttcccaaaga tttcgagcca ctgatcattt tctttaaaag 2504641 attctacatc agttacaaaa tacgagatgt cataatcttg gaagttgtca ggagggatat 2504701 ttctgtttgt acgtgaccct tccaaagtga ccaatcggat tctctcatcg ttcaaagcaa 2504761 agtccaaaaa aatgtccatc atttcctgct cacttcgcat tacatgttcc tccgtttcag 2504821 ccttaatatc taactgtaaa acgtcttata gattttttta ctcttgaatg tgatgtattc 2504881 ttctaagctt tattttacat gatgttctcc tatatatcat tcaatattaa gatgcaagac 2504941 atctcaaaat cagatatcaa ctatgacgga ctacatgaat attcagtttt ttgtagagcc 2505001 gccatgggac gacactatct ttgacacact ttaatccccc ctgctttatc gacatgttaa 2505061 ctggtatgag agattgacaa aaagaaggaa aacgatatat ttaagcgaat acgagttttt 2505121 gagtaaattt taaaatgaca cttttttcaa aaatcatgtc ttaacgggag gattcggtat 2505181 gaatgaattt atgaaaaagt tttctttaac aaaaccgatt attcaagctc caatggctgg 2505241 cggtattaca aagccccgac ttgcatctgc agtttcgaat caaggtgctc ttggcagctt 2505301 agcatcgggg tatcttacgc cagacctcct agaacaacaa ataaaagaaa tatttgagct 2505361 gacagacgct ccttttcaaa ttaatgtgtt tgttccgcta ggtctagaga tgccaccaaa 2505421 agatcagatt aaaaagtgga aagaaaacat accgttagct aatcaagtaa atcaattcac 2505481 atctgtacaa gaagagtggg atgacttcta tcaaaaaatt gatctaattt taaaatacaa 2505541 ggttaaggct tgctcattca cttttgatct gccgcctgaa gacgcagtaa aggagctaaa 2505601 aaccgctgga tgctgtttaa taggaaccgc ttcaacagta gaagaagcat tgttaatgga 2505661 agaacgggga atggatatag tagtccttca aggaagtgaa gccggtggac atcgcggagc 2505721 attcttacct tccaaaggtg aatctgccgt aggtttaatg gctctgattc cacaagcagc 2505781 agatgcactg agcgtacctg tcatagctgc tgggggaatg atagaccaca gaggagtaaa 2505841 agcagcttta accctcggag cccaaggcgt tcaaatcggt tctgcctttt taatttgtca 2505901 cgagagtaac gcacatccag tgcataaaca gaaaatacta gaagcaaacg aagcagatac 2505961 aaagcttacg acattatttt caggtaaaga ggccagagga atcgtaaata aatggatgga 2506021 agaaaatgaa cagtttgaga cacaaaccct tccgtaccct tatcaaaata cactaacgaa 2506081 ggcaatgaga cagaaggctt cacttcaaaa taaccatgat cagatgtctt tatgggcagg 2506141 tcaagggata cggtcattga ctgaggaaat ttcggttaag cagcttttaa atcagctttg 2506201 ccaagaggat ataaaaatat aggcgcacct cattgataga gcaaaaagca aactttgaca 2506261 ggcagtttgc tttttttttc gtaatttcat ccactgactc tggaaatcta aatactccta 2506321 cattttcaaa gctaatttga atcgggttat caatcatcac attgatacga tgcgatcttg 2506381 ataatttcac cacaaccaca atacattacc aacatttcga tcttatctcc ccttctcaag 2506441 ttttgctccc tattcgaata atcgatagct cccatattaa atttgaatag taaaatggtt 2506501 ctttttcgtt tgattcagat gatataaagt catatgataa aaaaagaatg agacagaaag 2506561 cgtgagaagt gatgaaaata ggattttttg attcaggaat tggtggcatg actgtattgt 2506621 atgaggccat aaaagttctt ccttatgaag attacatttt ttatgcagat acgttaaacg 2506681 ttccatacgg tgaaaaatca aagggtaaag ttaaagaata tattttcaat gcagctgaat 2506741 ttctggccag tcaaaatatc aaagctcttg ttattgcgtg taatacagct actagcattg 2506801 cgatagagga tcttcggaga aacttcgact ttccgataat cggaatcgaa cccgctgtaa 2506861 agcctgctat aaataaatgt acagaggaaa gaaaaagagt tctggtagtt gctactaatt 2506921 tgacgcttaa agaagagaaa tttcataatc tagttaaaga aattgatcac catgaccttg 2506981 ttgattgctt agctcttcca ggactagttg aatttgctga gaactttgat tttagtgaag 2507041 acaaaatcat taaatatcta aagaacgaac tatcttcttt tgatctgaaa caatatggaa 2507101 cgattgtgtt aggatgcact cattttccgt ttttcaaaaa cagttttgaa aaactgtttg 2507161 ggataaaagt tgatatgatt tcaggcagtg tcggtactgc aaaacagttg aaaaaagttc 2507221 ttgcagatcg taaccagctt ggtaaaggat cgggctcaat cacctttttc aattctggcc 2507281 ataaaattgt ggaccaagaa gtcatatcaa agtacaaaag attgtttgaa atattagatg 2507341 aaactcaaag gagtcatgtt ggacattgaa tgtaaatgaa aaagacaatc tcctgaagag 2507401 aaacatgaac taagaagcgg gcttaaaaag cccacttttt ttctaacaaa caattgagtt 2507461 atacacacat atctgattac agtgttttct ctctttcccc tcttatttct cccccctctc 2507521 tatagctttt ctatttcaat aaaacacaag tctcgattga aaagttatcg taacatttac 2507581 acttcacagg agatttttca cgattgcgaa tcgaccgttt gccagatgca caaagtcata 2507641 atgtgtaaat tctgtatcta tgtgcatgtt tattatggaa ttattttcat aatgttttat 2507701 aatacaagat gatagcgttt tctaattata atgatagggg gaaataatga tgatgaaaaa 2507761 aggtctgctt gcgggtgcgc ttacggcaac cgtgcttttt ggcacatgtg cagtagatgt 2507821 accgggtatt attagtccaa aaaccgcaga agctgcatca cagctaactg atggaatcgg 2507881 cgggagggct tacttgaaca gtaatggtgc cattcttgtt acgaaaatcc agcttcctag 2507941 ctccactcag gtttcaaatg ggacagccta catctactct ggttttagcg gaggcacaga 2508001 atccgatatc gggtttcagt acagtgataa atataatgta tggaaaccat atatgaaagt 2508061 cggttcaaaa ggacaggatc aggttcagta cctcgaagga ggaagccaat tcacgaatac 2508121 gaaaggcttc cgtcccggca gcaccgtaca acttaccatc tacaaaaacc ttaacggcaa 2508181 tacccgcgct acatactggg gcacgaacaa tgccggatac aacggccgtc tcatttcaga 2508241 aatcagcaaa acaaatgtcg gctccatctc aaaatggaaa gcgctcgcta cagttgcaac 2508301 aacagggtca cgccaatcta tcaaatcaaa cttttcaaca tcttttacaa acatcaccat 2508361 cgacaacaaa gcaataacac ctgtaattga tacacaagac ttcgctaaag taacagtctc 2508421 aggcaacagt gtcagtttat ccgttgtcaa aaattaaaac atgttaaaca tacaatgcgt 2508481 taggctattg agaagctctc gatagtctta aagggggctt aacatgcccc ttttttcatt 2508541 tcaatttaac tttcagttag cttcggtaca tgccgtctat ccccgtcttt tatctgggtg 2508601 aagtaagggc agctcgcccc ttctgaacct gttccatttg ctcaacgcaa aaggtgtgca 2508661 tcactgtctt aaaaatgtta aaacaaatag cagatggtgc actttatttt tagatgaggc 2508721 atgcttacgc tcgatatgca agtcaaatga ttaagggtct gcaagagaga gaagttttgg 2508781 gtgtactttc ataaaagagg gatggcttca tatagctcga ttgcatcagg aagattagcc 2508841 aacgattggc cgagaacaac acatcacttt gaaacggatt cattccaaaa tcataagtat 2508901 gatccaataa ctaataaaga tcagttagca gtccagcctt aaaaatattt ttacatcaat 2508961 taaactagca tcactatcga ataagctcga tctgcatatc atgtactatc ctcttttaag 2509021 gaaggtgatg ttatgaggtc atttccatta atcgtagttc tattcatcct attaatcatc 2509081 gttgggacat ctttctttgg tggctattaa gaacacacct tacctcatat ccatcagacg 2509141 ccataagaaa tctttatggc gtctgttttt tattagattt aaacaaaacc attaaagtgg 2509201 gccatgcaaa cacacctatg gagattactg ccacgacttc tttgtgaggg aattattctt 2509261 ccctttatgg actattgtcg atcaaaagag aaagttgaaa tgcattttta tggtgagatg 2509321 aatcgaggct tagacatata aaaaaccgca aagctttctt gaagaagctt tgcggttttt 2509381 gggtctcttc tttgcttcat ataagccaat agatttcaag cgtaatccac tgccatacat 2509441 ccaatgattt tttattttga aataggtttc ttctactctt catgtgagat gactcaaggt 2509501 atgccacgtc acaataatat ggcggatact gaatggtctc aatcagtttt ttccccattc 2509561 tatcaattct ccacagaaaa aatggctatg gcagaacaac tttcatagag taatcatcat 2509621 ttaatgagcc atcatctcat gggcaatatc gtgtccatcc atttttgacg ggtagtaagt 2509681 aggccagttt ttgacttcat caagtaaagc ttcacggtcg tccccccaat agagatggta 2509741 atgactagct ttagtcgggt aaatactatg atcactaaac tgaatatact gaggcagccc 2509801 ttctgctttt ttagctagtt tgaatatgta tcttacccct ctattgcccg catcataggt 2509861 tagaatttcg tatccgtcat acgtatactt accagaatat tcttttccat ttttgaagaa 2509921 cgttacagta tctttctgga ttacaatacg gtcaacatct gtttgatagc cttttttata 2509981 atactcttta tattcttcag ctgtcttgcc gccttcgtgt tctgatttat atgaaaacac 2510041 ttcgtcaaga gtaccatctt gcaggtatgg atatacagat tgccaatctc cttcccaatc 2510101 agaaagtaag cgatccttta cttggctgtt tttaaaatag ccttcatata ttttttctgt 2510161 ttcttcatca tgcgcatgac tatgatcgtg agaatgttcg tgtgtatgac tgtcagatgt 2510221 ttgctcttgc gttttggaag agtcttcttc aactgctgag gatgatgttg tttgattaga 2510281 ctcacctgca gaagaaccgg aagtctgaca tcctgccaaa actagtaatg aaccaatcgt 2510341 taatatgcct agccgttttg aaaataaaat gttcattcca acactccttt tttattaaat 2510401 cgaaaacatt acgatttatt atacatacat ctcttgcaaa catcaaagga aaaatgctct 2510461 tcatgcggat ggcctatttt aaaggaataa ctgactatgt tcatcagtta ttcctttaaa 2510521 atacgaaagt ctacgatatt tccatatcga tccgcttcaa tgtgacagca cccctcaagc 2510581 agctgtttta attttccacg tccgcgttgt acccttgatt ttgctccgga gtaagaaatg 2510641 ccgagctttt cactcaactc tttttgtgat aacccctgga aatcagttaa ctcgagcgcc 2510701 tctcgatact tttcaggcaa ccgtttgatg gtcgatcgaa tacacacagt tgcttccttg 2510761 gtgaaatttt cttcctctgc actgtcatta aaatgtagaa catcaggcaa tatttcgctt 2510821 gttttttttg tacggtaaaa atcaataatc gtatttctag tgatccgata aatccagctg 2510881 tcgatctttt gttcatcgat cagatttggg agatgcactt gtattttcat aaatacgatt 2510941 tgcaagaggt catcaacgat agattgatcg ttaaccctat gtgaaatata tgtttttaac 2511001 ggctgatgaa attgatccca tagatcctct atattcattt gaaaaaacct cctataattt 2511061 tgcgtctgct ttacatttgc ttcgtctttt taatcgtaac aaagagcaaa caattgttga 2511121 atcaattgta ttgcagctgt tgccaaaaat aatgataaag gagaggtttg ttgtggagta 2511181 tacctattta gggagaacag gattgcgggt gagccgttta tgtttaggca cgatgaattt 2511241 tggagttgat acagacgaaa agactgcgtt ccgtatcatg gatgaagcac ttgataacgg 2511301 cattcaattt tttgatactg ccaatattta cggctggggc aaaaacgcag gattgacaga 2511361 gagcatcatt ggaaaatggt ttgcacaagg aggacagcgc cgcgagaaag ttgttctggc 2511421 gacaaaagta tatgaaccga tttctgatcc gaatgacgga ccaaatgata tgaggggctt 2511481 gtctctatac aaaatcagac gtcatctgga aggatcactg aagcggcttc agacagatca 2511541 tatcgaattg taccaaatgc atcatatcga taggcggaca ccgtgggatg agatatggga 2511601 agcttttgag actcaggttc gctccggcaa agtagactat attggatcca gtaattttgc 2511661 aggctggcat ttagttaaag cgcaagctga agctgaaaaa cggcgattca tgggactcgt 2511721 cactgaacag cataagtata gtttattaga acgaacagct gaaatggaag tgctgccggc 2511781 tgcacgggat cttggtttag gagtagtggc gtggagtccc cttgcaggag ggcttcttgg 2511841 cgggaaggca ttgaaaagca atgccggaac tcgtacagca aaaagagcag atttaattga 2511901 aaaacatcgt ttgcaactcg agaaattttc agatttatgc aaagaactag gagaaaaaga 2511961 agcaaatgtg gctttggcat gggtgctggc aaatccagtt ttaactgcgc cgatcatcgg 2512021 accacgaacg gttgagcagc tgcgtgatac gataaaagcc gttgaaatca gtctggataa 2512081 ggagattctc cgcatgttaa atgatatctt tcccggacct ggaggagaga cacctgaggc 2512141 atacgcctgg tgatacattc attactcaat actgacattt ttcttaaata tttatactga 2512201 actatcatat taagaaagac aagagcatgt ttgtctcttg tcttttccac atcgtgctga 2512261 aaatgctggc taaacatcga caaaaatgct gccgcttaaa aaagaaccct aaacaataga 2512321 gtaactggaa agacaactgg cttgatcagc ttgggacccc tttcagctgt atttaaatca 2512381 atcaaactaa tgattcattg gcagtctaaa tattattatt gtttctttac aaaatagtaa 2512441 tagcccctgt aatgattgct aacaacgtaa taactaatga tgtaattaca gcccacttaa 2512501 cggcaaacct ttgaaatgac cccaagtcca ttttaagcat gcttactagc aatactgttg 2512561 acgcaaccaa tggactcatc agatgaaccg gctgccccat tatagaagcc cttgcaattt 2512621 ctactggttc tataccatat gctgaggcag cttctgcaaa gataggtacc ataccaaagt 2512681 aatatgcatc atttgataaa acaaaagtaa acggaatact agtgagtgct acaataacgg 2512741 ggaaaaaccc tcccattgat gaggggatga tggatattaa tgatcctgct atggcatcca 2512801 ccatctttgt cccggataat ataccagcaa atactcctgc tgaaaatacc aataatacca 2512861 cggttatggc attaccagaa tgctcggcga ttcgctcctt ctgcattttt acattcggat 2512921 aatttatagt aagggcaaga acaaaaccaa ttaaaaataa aactgacgga tgcttagttc 2512981 caagcacaat aaacaccatg atacttataa cgaggaataa attaagatat attaagcgtg 2513041 gccttttcaa ttgttcgctc tccaaagtag cagccatata agattgagag ctgtcctttg 2513101 ttatatgtct aggctctaat tgaacgatgc ctattcgatt cctctctttc cttcccatta 2513161 gaaaagccag aaatatcaca caagcaatac ctccaagcat ggtcggaagt aatggcacaa 2513221 agaaatctga aggatccaaa cccagcactg aaatcgctct tgtagctggt ccgccccatg 2513281 gagtcattcc gctaacgata ctcaacgaca gcattgctaa tgtcgccata accatgggat 2513341 tcataccaat tcttttatac aaaggtaaca ttgctgagac tgttatcata taggttgttg 2513401 taccgtcccc atctaaagcg ataagcattg ccaagacggc agaccctatc gctattttca 2513461 cagggtctcc ctttactata gataaaattt tttctattag cggatcaaat aaacctgcat 2513521 caattaaaat tccgaaaaaa agaatagcaa acaatagcaa tgccgctgaa cttgcaactg 2513581 tttgaattcc ttctaaaatc atgtcgccaa tacccttacc aaaacctcca ataagagcaa 2513641 aaacaatggg agtgatggtc aaggcaacaa taggcgagac tttctttgtc attattaata 2513701 ttgtaaaaac agttaccatc gaaaaaccta aaatagtaag catattacac ctccaagaat 2513761 gcgctttcaa atgacttttg attaacatat cttatacggt gtaataagtt aaataaatat 2513821 ttttttactg tgtttcaaaa aaaattctat cataacttta aatggttacc atttgttcac 2513881 cctttaaaaa atcaatgaat gctttaacga gtttgattcc taatgatttt tgatcgtaca 2513941 ttagccaagt atctctcatt agaggcttac ccttagcatt atacagttcc attgtgtaca 2514001 aatgatcaga ttcctgcagg caaatttctg gtgctatgga gtaaccaaga ccatgcttta 2514061 ccatctcttt gcaagtctct tgtcgatcca cttccattgc aataatgggg gcttgtttta 2514121 gattcgtatg catccaatct tctataatcg tttttaaaga agcatccgtt ttatatttga 2514181 taaaaggtaa aaaaggaagt tgctctatcg ttattggttt ttttgagatg atatgtaatt 2514241 tttcccgtgt cagccgttcc tccacccctt tccagcgatg gcttcctctc agtataccga 2514301 cttgtacaat accagcatct aataatttca tgacatctgt gctccagcct gtttgtacac 2514361 tatattggac attaggatac atagtggaaa attcccttaa taacttaggg agcttatatt 2514421 gagcgaaatt gcttgatacc cccagcctta gatgtccttg cacctctttg cttagattag 2514481 agatatgatc tttggtatct tgaagttcct gtagcattct tcttgcataa gcaaccaagt 2514541 gttctccttc cgcagtaaag gtaattcctt tatgcctttt ggtgaataat tcaattccga 2514601 aaatctcctc aatctttttc aaccgataag tgatggaagg ctgtgatgta aataatcgtt 2514661 ctgctgtttt tgttacactt tgttcttcgt gaagaatttt caataaaatc caatctttct 2514721 catccatttt catcttcctt tctagtcctt ctttcacaat tataaaagtt tttttatcga 2514781 atattaagaa aacttatatt ttatttttat ttttttacct tctacactaa aaaacataaa 2514841 aaatactacc tttaagatga ggatgatgac gatggtcaag acgaatgtaa caatcatgag 2514901 aggcggaaca agcaaaggcg tttttttcca cgaatcagcc atgcctaaca ataaaaacga 2514961 atgggagccc tttttgcttg atgtcatggg aagtcctgat aaaagacaaa tagatggttt 2515021 gggtggcggt aattccctta ctagtaaagt ggcaataata aagaaagcat atacttcgga 2515081 tattgatgtt cactatactt tcggtcaagt cagcatttcg gaagaaaagg tggactttaa 2515141 ggggaactgc ggaaatatct ccgctgctgt tggtccattt gctattgaag aaggacttgt 2515201 aaaagcgaaa gaaccaatga ctgcggtaag gatcctgaat accaatacga ataaaatgat 2515261 cattgcggaa gtagaagtgg aagacggtca ggtcaaatat gacggagatg ttacgatatc 2515321 tggagtacct ggatctggat ctccaatcta tttaaacttt catgatgccg ctggttcagt 2515381 taccggtcat ttattgccta ctggaaatag ttcggagttt ttagatacaa gtcaaggcca 2515441 aatagaggtg tctattatcg actatgcaaa tccattagtt tttgtggaag cgagcagtat 2515501 cggcctggat ggaacggaac ttgcagaaga atttactgat ctacagttgg ctcaatttga 2515561 agaattaaga tccattgcgg cagagaaatg cggctttgcc agtcgatttt cagctacaaa 2515621 gttatcgccg gctgtcccca aactggctat agtagcaaaa ccagagaaat ataaagatag 2515681 tacaggtgct tggcattcaa gcgttgagat ggacttacac atcaggatga tgtccatgca 2515741 aaagccacat caagcactgg ctgtcactgg agcgatatgt acaacaagag ccctttcagt 2515801 ggaaggtgca atccctgcaa gaatagcaaa aaaccactct acaaaggttc ggctagctca 2515861 ttcttctggt attattgaaa caatggtgga gcccactggt ataaagatcg tccgtaccgc 2515921 acgacgtatt atggacggaa cagtttatac gcatggagac tatcaaatga tgtagatgga 2515981 ctgtgcaaaa agcctccccc ctttccatcg ttaatagatg gattgaatgc gccttcttgc 2516041 acagatccat tgtaatcttg catggcttta aaaaagcctc tatattgttt tttatgaaat 2516101 cgccaaggtc ctttcatgta tctgcctcaa gcatgacata atcattatag agaaaattga 2516161 atacttttta ctgcaaataa aaagatacca acatcattgg tatcttttag attgagttca 2516221 tctgcagcgg tttcttttcc tcactgctta tttgattaca aaattaccgt actcgtttga 2516281 acgaacatga atcggtccgt ttagattata gttgttctcc ttggcgatag agcgaagcac 2516341 gtccacacgg gcaactgatt ctctccattc gtcacgggtg tcatgattgg ccggattcat 2516401 cagatcgtca tagcgtacgt ccaagaattt attcaaccac ttcttctcgt ctattccgtc 2516461 tttaggtgat ccgcccgctt ttttgttcgt acgtttaatc aaggcataaa aagagtcagg 2516521 gtcatcacca tcgccatgct gaataaccgt atcgtacatc acagctcttg ccaatgctgt 2516581 ttttagtccg gcattatccg atcgtttcat ggcaggctga taatacaaat ggtcatttac 2516641 tttgtcttga gcggcgcgaa attccttatc atttgcaagc gacttccagg cagaagcgaa 2516701 tcccttgaga ttgcttgtat catcgctttc ttccttggcc agacggcgca attcaggcag 2516761 atactttttc agtttgttat tcggaactgc ctttgtgtat acttccacta cttccaatgc 2516821 atccccggta gccgttgtaa agcctgcccg tccgcatgta tagcctcgcc cgtcatccaa 2516881 tcgctctaca tatccatatt ggatctccgt tgtgccgttt tcaaagatac ttgtcagctg 2516941 ttccgcccgg cgcttttgat ctttattcag tcccgccgca aaaaccgttt cgctcatcat 2517001 cagggtaaaa aacatggtga aaacaagtaa tgagatcgct gcttttttcc aaaaatctgc 2517061 tttttgcata ctgattttca tttcacttcc cctttctaaa tattgtaaat acagactcag 2517121 tatacatgaa gaaactgccc tattgttgaa aatacatcaa tttgtcaata ttttgaatct 2517181 aaagtaatat agcttgaatc ttactctatt cattgccaat cagccttagc ccctctcact 2517241 gggaaggtcc cttgattttc atactgcttc aactttcatt aacaagatgc cataaggctt 2517301 tactctattt tataatggaa gtgatcatcg aaaatcgtta gggaggtgat gtaatggcaa 2517361 gcaagatgag aatgccagat tccgcaacgt cccatgcaaa gcctactatt gggaaggcga 2517421 tactttgcat ggggtagact ttctaaaaga tcgcccaagt aagcttttct gatatagtgg 2517481 ctttgcacct tatttgacat aaaaaaataa ggagctggca gaaatggcat atgtaaaagc 2517541 aaccgctatt ttacctgaaa agctgatatc ggaaattcaa aagtatgttc aaggaaaaac 2517601 aatatatatc cctaaacctg aatcctctca tcaaaaatgg ggtgcgtgtt caggaacaag 2517661 aaagctgatc gatgacagaa acgcttctat taaaaaagca tttaaaaacg gcaaaaccat 2517721 tcatcaatta tctgatgaat atcacctctc tattgaaaca ataaaaaaaa ttgtctactc 2517781 taaataaaca aaacggaagc actgataaaa aataatcagt gctttttata tggcgagttt 2517841 gtttcttagt tatttcctgc atatgatacc attggccaat tgtgtaaagt taagggagat 2517901 gagaagaaag gaaggtccta caaatgacga taaacaatgg aacgttgcaa gtacccggcg 2517961 cgaacatcca ctatcaggtg cgtggctctg gtccaatcat tcttttggtc cacggaggag 2518021 gcggtgatgc cgacaagttc catcatgttg ccaatcatct ggctaactgg tacacggttg 2518081 ttacttatga tcgccgcggc cattcccgca gcaatctcgc caatcagatt gagggttacc 2518141 gtgtggaaac acacagtgac gatgctcacc gtcttctagc caaaatcacc aataagccgg 2518201 cctatgtatt tggaagcagc tccggggctg ttatcgggct tgatctgtgc atacgccatc 2518261 ccgaacaagt acatgtcatg atcccacacg aaccaatctt attgcagctt ctgcatggaa 2518321 atgagctgaa acaagccgag caattcatgg aagaccttaa gaaaaatcat cgaagtgaag 2518381 tcattaaatt aatgtcaaga ttagagacag acgaacaatc aaaggctgtc ctgacaaagc 2518441 ggcttctcgg caattcaacg tatttcactg agtatgaaat tcaaggaatt ctcagctata 2518501 cattagattt cgaagcatta aaaactgtgt ttacatcttc accgatgaag atactcccag 2518561 ctggcggaag tgcttctcgg gagctttttc cttatcgttg cgcgaacgcc ctagcggaac 2518621 aattggaaac agaatgggtt gaattccccg gaaatcatac ggggtacaca atgtaccata 2518681 aagaattttc tgagaggtta cacgacatgt tagaaaaaga aaagaaacat acgtgttaag 2518741 gattgattaa aattttcaaa ataggacagg tgaaactaac tatggaattg gagaagattt 2518801 cacgaagcgt aaaaagaact tttcactaac gagaacgcaa tgtgagatgt ttaaccaaag 2518861 tgatattagg gatttcatcg aaaaataggt ttgtacatta cgttctccta ttgattattt 2518921 cctatcttaa ttccgtattt tataccatta gatacaactc taaagcggct cgttattttg 2518981 tcctcaacaa caaccagtgt ctaacatcat gaatctcttt tgaaaatcac cacaaatgca 2519041 ggtatggaag acttcatcgc agcaaaaacc ataccaacta ttgttgttgg tatggttcgt 2519101 cctagatagg cccttaagaa gagattctat tgtacggagt atttagctaa ttgcatttgt 2519161 aaccgacagg gccgtctgaa cctgtgtaca catatgtgtc agacacatat ccaatattca 2519221 cgacaccccg ggaatctttc cactggattt ggtcccagat attactcgtt ccatacttcc 2519281 ctgtaacagt cgttccataa gcgtaacaat aataaggaac acgggagcca ctcggaatgg 2519341 aaagcataat aggataattt gtaccaggac cgctgcgcat attgacaggc gcaccgctgc 2519401 ttgttgagac agtaaagtac tgaacggcaa gtgcctgact ggaaaaaatg aataaagatg 2519461 caatcatcac ggttaacata ctcagcattt tcagtttagt caatgtcatc cctctttctt 2519521 caattccttc attttaagaa acgatagaac ataggctacc agctgcattt aggaacaacc 2519581 ggaccgtctg agcctgtata catatatgta tcagagacaa atccaggaac gatctccccg 2519641 ctggcaagcg tccgctctgt gtaattccaa atattgctcg ttccatactt tccagttaca 2519701 gttgtaccgg ttttgtagca atagatcggg atgcgggttc cgctcggaat ggtcgttaca 2519761 attccccaac ttgtacctgg gccgctgcgc atgttgacag gagcaccgct gcttgttgaa 2519821 accgtataat actgagccgc aagtgcatgg ctagaaaaaa tgaacacaga tgcaatcatc 2519881 accgttagca tacttagcct ctttaactta ttcaccttat accctcccct tataaatgcc 2519941 gtacgtttga ctttcttaca tccagttaag gatttacttt cagataccat gccccctccc 2520001 ctcccatata tttatcaatg taccataaac tagatctttc aaaagtggaa ttattcctat 2520061 gttttcgaca attaaggata caaaataaat ggtagtcagg cttgatattg atggtgtgtt 2520121 acatttggct cttaatcatt tgtccagtcg gtaatcacga ttgacaatca ggaaaaagga 2520181 catggatcaa gcggcttcgt ttccaccaat taactcaatc agtgtactgc ttccttgtat 2520241 ccacgcttct tctcgattca tagatactcc acctttttca ccaatcaaaa acggacacca 2520301 tacaaatcag cgtaaatgct gcaagttcag tgtccgcaac ctattatgac tttgctttct 2520361 tttaccaggg cgtgtaaaaa tgattaggta cgttatcaaa cgttattcta tgattttgcg 2520421 agtcaaaaaa tcataacatt ttatatattt caatcagatt atgatctgga tctctgaagt 2520481 gagcaactcg ggcactccat tccttgcgat catgcggttt attctcacat ttaactcctt 2520541 tttcgtgtaa atcgtcatac gttttatcaa catcttctac cttaaactga agcaaaaatt 2520601 ttgattgagc ttctccttcc aaggactttt tttcctctcc aacgatttca gccatcgttt 2520661 ctcgagataa aagctctatt ttcgtttccc cattatcaaa gagtgcatat tccatttcat 2520721 tctctaacca acttattgga agtcctaatg aatctttata aaactcgacg cttttcttaa 2520781 aatcattcac caacagtcta atttgtaaca gcttcatatc gagtgcctcc tataaaacca 2520841 tacttttact ggtcatccaa tttaatgata ccaaagaaac ctgacagcac tatgtcaagt 2520901 ttccatactt cacccttatt tcagatttaa gtgcagttta gtccatgtca taagaacgag 2520961 caaaaacagc gattcttaaa acaaaaaatg ataccgagtg tattttctgt atgcttcaac 2521021 ttcatttcgg gaaatgtaac gttgataaaa ggaggttaca tcaatatgga tcatcaaaca 2521081 ttggcagctc atgaggctgt tgacttacat gaaatcgtga actttaaaac actttgtata 2521141 gcgaaatcaa agttaatgca agggcttgtg tttgaccaag aactgaagga cttgatggaa 2521201 aaagatgtac agcaatccat tcaagacctt actgaattac aagcggttta tgagcgtgcc 2521261 tcatttcagg cccctgtccc tcaaagccgc ccaacgccaa tcatcaattg aaagggaggt 2521321 aagcctcttt gaataatgat catttagacc ccattaattc gctgaatgtg cctgaactag 2521381 cagacactac attcgcgatg gattttctta tacgagctaa ggaaggcgta aggaatactg 2521441 ctgtagcttt gacagaaacc gcttcaccag atgtaagagc actgcttcgg aaacagctga 2521501 tgcaaggaat tgcgatgcac caagagatta cggaactgat gatcagcaaa aagtggttcc 2521561 atccatatga gctgagcgaa cagtataagc tggatcagct ctctgcaaaa aacacgatca 2521621 tggtcggcaa tatgaacctc tttcctgatg aaacaaatcg caaagggatg tttgaccgga 2521681 cacctgatga acactaacac tggaggtttt acagcatgaa ggcagtaacg tatcaaggca 2521741 ttaaaaatgt tgttgtcaaa gatgtccccg atccaaagat tgaaaaatcc gatgacatga 2521801 ttatcaaagt caccagtaca gccatttgcg gatcagattt acatttaatc catggattca 2521861 ttccgaatat gcaagaagac tatgtcatcg gccatgaacc gatgggaatc gtcgaagaag 2521921 ttggttctgg ggtgactaaa ctaaaaaagg gagatcgggt aattattccc tttaatatag 2521981 catgcgggga atgctttttt tgtaaaaacc agctggaaag ccaatgtgat cagtctaatg 2522041 acaatgggga aatgggtgct tatttcggct attcagggca aactggcggt tatccaggcg 2522101 ggcaagctga atatttaaga gtgccgtttg cgaattttac ccattttaaa atccctgaat 2522161 cttgtgagga acccgatgag aaattaagcg tgattgccga tgccatgacc accggctttt 2522221 ggagtgtgga taatgccggc gtaaaaaaag gcgatacagt tatcgttctc ggctgcggac 2522281 cagtcggcct gtttgctcaa aagttttgtt ggctaaaagg cgcaaaacgc gtcatagcag 2522341 ttgactatgt aaactatcgc ttacagcatg cgaaacgtac aaacaaagta gaaatcgtta 2522401 attttgaaga ccatgagaat acagggaatt atttaaagga aatcacgaaa ggcggagcgg 2522461 atgtagtcat tgacgctgtt gggatggatg gtaaaatgag cgatctcgag ttccttgcca 2522521 gcggcttaaa gcttcatggc ggaacgatga gtgcattggt cattgcttcc caagctgttc 2522581 gcaaaggagg aaccatacaa attacaggtg tgtatggagg cagatataac ggttttccgt 2522641 taggagatat tatgcagcga aacgtcaata tacgctctgg acaggctcca gtgatccact 2522701 atatgccgta catgtttgaa ctagtatcga caggcaaaat tgatccggga gatgttgtca 2522761 gccatgtcct gccgcttagt gaagccaagc atggctatga catttttgat tcaaaaatgg 2522821 atgattgtat caaagttgtg ttaaagcctt aaaaaacgga ggttacagaa atggaatacg 2522881 ccttacacga agtgcttgag gttcaggaaa tgactgcatt taagacactt tgtttgacga 2522941 aatctaaaac aatgaaagca ctggtatctg atccgaagct gaaagaaatc atgcagcaag 2523001 atgttgatat caccacacgc cagttgcagg aatttgcctc tattttatct aatgcaaagc 2523061 aagaatgagg agatgaataa atcatgaatc ctatcataga atatctgact ggcatgaatg 2523121 ttctaacaga ccaaatcatt gctatggact tattaatttc agcaaagaac ggagtcagaa 2523181 attatgcgat ggcagccact gaagccggaa cgcctgaagt aaaagaggtc cttatccgcc 2523241 atttggaaga agcactcgat atgcacgaac aactctcaag ctatatgatg gaaaaaggct 2523301 ggtaccatcc ttggaaccct gacgaacaag tcaagctgaa tttaaaaaat attgatacag 2523361 ccattcaatt gccaaccctt taacatacaa tgactgattt gctgaggaac agtattgatt 2523421 ggccacaact gttcctcagc ttcaaaatga gcactgtttg ttcgggtcct atgaccgtaa 2523481 atagattaac cgcttttctc catctgatct ccgataatgt ttgcaaattc tccaatccaa 2523541 ataaggaatc gtaaccacct ctttttatgc gatctcttga tggagaaaac aggccagaaa 2523601 caaaatcctt cgtttttgac ctgccctctt cacacgcaaa gaatgctacc ttctttgctc 2523661 cactgatccg tgaagacttt ccgttttagg cctgcttttg agctttgcct cattttcacg 2523721 caatttccca tcataatctt taatttttgt gtctaatctc ttaattgttt catcaatttc 2523781 tttccgcttc tctatcagcc gctgtcgttc gtcagccagg atattttttc gagcttctac 2523841 cgtacggtca ccttcggtaa ataatgttgt atattcaatt agcgcttcta tcgatagtcc 2523901 cgcatttcgc atgcatttaa tgaattcaat ccatttgata tcttcttcat catagtcgcg 2523961 aatgccgctg tcttttcgtt ttacaggcgg gattaatcct acacgttcgt aatatcggag 2524021 tgttgcggct gtcaggccaa actgctttgc cacctgagca atattcatga tcttcacctc 2524081 tctatcctgt atgttgtgaa ggtaacactt aaagttaact ttaagtcaag ctcaaaacaa 2524141 gtggttagct gctgaatctg ggtttatata ttcgggactt gccttaaagc acactttaaa 2524201 ctctatactt ctccatgcac taaaaacagt gtagttggag ggattgctga atggcaaata 2524261 aacacactgc cggaagagaa caattaggag aatttgcgcc aaagtttgct gaacttcatg 2524321 atgatgttct attcggtgac atttgggcaa gagaagaaga actttcatcc cgggatcgca 2524381 gcatgattac agtttctgca ttaattactg actgtttctc agcttataaa tcaggttcat 2524441 tttaaatggt ttttttaaaa aacccttgcc ttaaagcaga ctttaaggtt tatcgttatg 2524501 ttgaagacac cataaaacat aaataagtgc atgtttttat ttacaacact tatgatgaag 2524561 aaaggatagg ttcgtatgtg taatcaacat caaacccgtg tattaagcgt gtcacatgca 2524621 aaagccaaat ttgaacaaac gacgattgag cgaagaggat tacggccgca cgatgtctta 2524681 atcgatatta aattcagcgg catttgccat tcagacattc atagcgcttt tgatgaatgg 2524741 ggcggtggca tcttcccaat ggtgcctgga catgaaatag ccggtgttgt aacagccgtt 2524801 ggaacaaaag tcaccaagtt ggctgtcggg gaccgcgttg gtgtcggctg ttttgttgac 2524861 tcttgcggag aatgcgaata ctgtctcaac gcagaggaac aattctgcac gaagggtgtt 2524921 gttcaaacgt ataactcagt agactacgac ggaaacccca cttatggcgg gtacagccaa 2524981 aaaatcgttg tcactgacag atttgttgtt cgcataccag atcgtttgga aatggatgtt 2525041 gccagtccgc tgttgtgtgc aggtatcaca acgtattccc cgctgaaaca ctggaatgtt 2525101 ggccctggta aaaaggttgc gattgtaggc gtaggtggcc ttggacattt ggcaattcaa 2525161 tttgcacatg cgatgggtgc agaagtaacc gtcctgagcc gttccatgaa taagaaagag 2525221 gaagctctgg aactcggtgc aaatcattac tttgcaacaa gtgacccagc cacattcact 2525281 gcattggccg ggcgttttga cgtgatctta aatacggtat cggcaaatct cgatgtagat 2525341 gcctatttat caatgcttcg tatagacggg acacttgtaa gcgttggagc tcctgccaag 2525401 ccggacacat acagtgtgtt ttccctaatc atggggcgcc gcagcattgc aggttctcta 2525461 gtcggcggaa ttcaagaaac tcaagagatg ctggatttcg cagctgagca tggcatcgaa 2525521 cctaaaatcg aagtcatcgg agctgaccaa gtggacgagg catacgaacg tatcctccga 2525581 agcgatgtcc gttatcgatt tgtgattgat atttccacat tgtaataggt tagtccttat 2525641 atgggctgcc gcttttattg aaactcacga aaaatgatct ctttaagcaa atattttgaa 2525701 ggccggtcaa tcttcctgtt attctatgaa tagagagtta ttaggagggt tttttatgag 2525761 caaaaaaatt gcagttcttg ttacagacca attcgaagac atcgaatata caagtccggt 2525821 aaaagcatac gaagaagctg gctacagtgt tgtggctatc gatttggaag ccggcaaaga 2525881 agttaccggt aagcatggcg agaaagtaaa gattgacaaa gccatctctg atgtggatgc 2525941 aagtgacttt gatgcacttt taattcctgg gggattctct ccggatttgc ttcgtgcaga 2526001 tgaccgtccg ggtgaattcg caaaagcatt tgtcgaaaac aaaaaacctg ttttcgcaat 2526061 ttgccacggc ccgcaagtac tgattgatac ggatcttcta aaaggcaaag atatcacagg 2526121 ctaccgcagc atccgcaaag atttaatcaa tgccggtgca aactacaaag atgcagaagt 2526181 agtcgtcagc cacaacattg tcacaagcag aacacctgat gatttggaag catttaaccg 2526241 cgaatcttta aacttgttaa aataacaaga aggcacagac tgttcgggtc tgtgcctttt 2526301 ttaaaattaa gactccttcg ttacattctg aaagacagca gtcgcgtccc acacattcaa 2526361 gccaaattgg ccttctgaaa atacggaatc atgtgcatca atcacaagac gatcatctaa 2526421 atagatttta aagcgatcgc cctcggcctc tgttttcaga tgatactttt tattaacgtc 2526481 tatcggtgtt ttgtattcag caatgacaga agcagcaccg ttctcaaatt taaagaattt 2526541 cactaggtca tgcttcgcat ccacattggc aaggtaaccg tttttggcat ctttgtcaga 2526601 gcgaaacatt agtgctcctg cccctcttcc gtttccatcc ttaatggtga tatcagattc 2526661 ataagtgaag tctgacccgg atgctgaaga caagataaag gaatcgccgt ccgacctccc 2526721 ttgtttcccc tcaattgtgt ctgcccacgt gccatttaca gtcgtccagc cagtcatatt 2526781 ggacataaaa ggtgtcgttc cccatacctt ttttaaaggg tgtatcgtta aagattttac 2526841 ctttacaccg ccatttgcag catataattc aagccctttg cttgatcggt ctgggagaat 2526901 aatatccgtt atgacctgct ttccgtcatt cccaaatact tcaaccgagg agcggtcaac 2526961 aaaaatgcgc aacttaacct tcccatttac cggcttcaac ggggctgttt cttttccggt 2527021 gttaaaggcc ggattaaagg tgtcgttgcc tgactcgctc cggtcaacga acaatttggc 2527081 gttccttcgg tcatagccga ccttcgtaaa ttgattttca cctgttcgga ccttaaaacc 2527141 aaattcagca gctgaaccag ggcttacttt aaattctgca tttatttcat aggcatctcc 2527201 agattgcccc gctaacacat tatgacttgc aggcgatatg gtcagattct tccacttctt 2527261 agaggttccg cgaatggttt ccagctcttt caccggtgtt tggaccactc taaccccttc 2527321 ggtaaacgct ttcaatttta actctcttgg aatggacgtt gcacttctcc atggggatgt 2527381 cggaacatca ttcgcatatt gccaattgct catccaccct aaccatagcc ggcggctgtc 2527441 tgtggatgga atatcagacc aggatacagc cgcataaaag tctctgccgt aatccgtcca 2527501 gagaactttg tttggcgggt tttcattttt aaaatgagtt ccatcaaagt cccctacaaa 2527561 atattgcatg cctgatcctc ccgagaccgc tccgtttccg acactgacct gcatgaccca 2527621 tttcttttga ttcggattgc cgtctaccgg aagctcaaat aaatccgggc attcccatac 2527681 tcccccgtgg cttccttgat cctgtccaaa ttcacttgca tacgtccact gcttcagatt 2527741 ttttgatgta taaatgagga ttcggtcacc ggccgcaagc accatcaccc actttttttc 2527801 tttctcatac caaaagactt ttggatcgcg aaaatctttt ttacccgggt ttggaatgac 2527861 agggttgcca gcgtacttcg tccatgttct tcctttgtcg ttgctatagg caatactttg 2527921 cacttgatgg ccttcccgat cctgtgtata aatggccaca agcggcttct ctttgcctgt 2527981 ttgaaaaccg cttgtgttat ttttatctac aactgcgctt ccagaaaaga tcgtgccttt 2528041 ttcatccgga tacagcgcaa caggaaggtg ttcccatgta accaaatctt tgctgacggc 2528101 atgcccccaa tgcatgggcc cccactgaag cccgtatgga tggtattgat agaacaagtg 2528161 atattcccca gcataatata ccattccgtt tgggtcattc atccagtttg cctccggtgt 2528221 gaagtgatat tgaggacggt aatcctcatc atagtagctt gaatcggctg catctgccga 2528281 aaatgccata gtcaacagca gggtgaacat gatcatgact tgaatcagtc tctttttcat 2528341 ttgttccttc gctcctctct tcatgtttga acactttcaa aagagactgc tgcgcaagct 2528401 ggtccgtttc tggcaattct cctctgtttc actgttatcc gaatgattta tatatgaaaa 2528461 gactgctgca gtttctctct ctttccttca cacaccttat gctaagaatc cagcccaata 2528521 cccgagaatc ccgatgacaa agatgccgca aataatgaga agtggattca cccctttgcg 2528581 aagcatccat gccaccaata acgttaatcc gagaggcagc gcccccggca taatgctatc 2528641 tagcacgttt tgtaccgttt gaacatctac ttttccgctt tcatccttaa tcctggatac 2528701 aacgattgga atgttgatgg tggtccattt ggacacgaga gcccccataa caaataaccc 2528761 gagaatcgaa gcgccctctg taagcttttg aatgcgattc cccgctaaat cctgaagaat 2528821 ctccattcct ttcacatagc catactttaa tccgtaatat tttgtgctta atcttatggc 2528881 attcagcaag aaaaagaata gcaaaggacc ggcaatgttt cctcctaaag caagggaggc 2528941 tcctagcgca gctaagacag gacgaatcgt tccccaaaaa attggatcgc ctacgcccgc 2529001 tattggtccc atcaaaccga ttttcattcc gcttatcgct tttccgtcaa ttcctttatt 2529061 gttcgccatt tcttcttcca tggctgccgt cacgccaaat ataggcgctg tcagccacgg 2529121 atgtgtatta aaccattcca aatgccgctg taaggcttcg tttcttttcg ctccgggacc 2529181 gtacaatttt ttgatcgccg gtatcatgac ataacaatat cccattgcct gcacacgttc 2529241 gaagttaaag gaaccgagta aaaaatttga acgaataaac atgctgaaaa tttctttctt 2529301 cgttaatcgt ttttctttct ccattttttc ttccccctca tcgtttaggc atcaagatca 2529361 tcatcatcgt catcataaac agcaacactg ccactgtctg atgcggccgc gactgctccg 2529421 tgagcgcttt gtttttgcat cacctgctgg tataaaagcg ccagacagag accaagggct 2529481 ccaaatccca ctaagttaaa atcggtaaac gccgctaata agaaaccaat atagaaaaat 2529541 ggctttaaat aaggaatatt catcatattg atcaccatgg catacccgac aaccacaata 2529601 atgcctccgc ctatttgcag tccttttgta atgacatcag gaatatttcc caggaacgcc 2529661 tgaacagcgc tgacactaat taaagcaaca atcaatgtag gaatcatgac gcgcaaagct 2529721 tgaaacacca tcgcggtaat atgcataatt tcaattcctt ttatatttcc cgcttttgca 2529781 tattgatcag cgcggtggat gaaaaagaca gtgatcgtcc gaacaaaaat cgtcagcgcc 2529841 tgacccgcag ctgctaaagc aacagcgaca gcaatccctt cgccaattcc ttgatcagcg 2529901 gtaataacta aaatggttga gatgacagag gcgatcgctg tatcaggtgc catggcaagc 2529961 ccgacgttca tccagccgag cgccatcagc tccagtgtgc ctccaagaat aattcccgtt 2530021 tttaagtccc cgagcaccaa gccaaccaac gtacaggcca ctagcggccg gtgtgtctgc 2530081 ccttcatcca atacacttgc gattccggtg attgctgcaa tgattaacaa caaaataatt 2530141 tgtaatgaag acatattctc atccccttga ttattttgtt acgttccgta aaatctgtac 2530201 aaaatcctca ctggcatctg aaggcagctg cctcaattcc agtttcacgc ccttgtcact 2530261 taatgtttca aatgccttta tatcttgttc tgtgacactg actgattttg tgatttgcct 2530321 gcgatgattt tcaaaacgca ttcccccgac gtttacggtt ttgatcggta cacctgcttc 2530381 tataagagat acaatatcgg acggattttc aaacaagagc attgccgtta ccccttcgta 2530441 gcgcggacta tgaaatgctt ttgccatttt agaaaccgag acggcactcg cctttacatt 2530501 tgaaggcgca acagaaagga tcagcgtttt tctcatttcg tcctgagcaa tatcgtcgga 2530561 gacaacgatg attcggtcgg ctgcatggac ttttatccac cttgtcagga tttggccgtg 2530621 aataaagcgg tcatcaattc ttgctaacac aatgttcatc ataattcatc ctctcttgta 2530681 tcttgattgg ctgtttttac tttttctaaa tgttcactgc acacttgaaa gctttgctga 2530741 ctcattgctt ttaagttgtt cagcaaatct ttgagagcca gatgttctct caggcttaat 2530801 acctccagca gaatcggcag gtttacgccg gcagccatat ccattctttg atcctcagca 2530861 ataaaggaag ctgccgcgtt atatggcgtc cctccaaaaa tatcgactaa aaaaagcact 2530921 tcatgttctt ccgggatatc cttgagcgcc tgatgatatt tttcttgcag cgtttgtatt 2530981 ccttcccctt tgaaaaacgg cactgcaatc aggttatttt cttcaccgaa tatcatccct 2531041 gaagactctt ttaatgctat gggaaaatct ccatgaccgc tgataataac tgaaatcata 2531101 tctattgctc ctttcctgtt ttgtacatcc atatataatg caaggatcgt gccaacacag 2531161 ttgtgttaag cgttttcatt gttatttcag ccaatagcaa tttgttgttg aaacacttaa 2531221 aacgaaaaaa ataaacctgt attaaaatgg tgttccattt aatacaggtt catatgaaaa 2531281 aactgttttt aaaacagctg gccatgcact tcttcagcaa atatggcggc tataaataat 2531341 ttttcatcat cacttatgcg aagtccgagc ttttcttcat aaggggctaa tgttcgctct 2531401 gtcacgtaca ccatttcctt cagctgatca ttgatctctt cttcctctga gaaagcgatc 2531461 ggattctgct taattaccct ttcaaaggcg aaagccgtgt gcataatgac tttgatcaaa 2531521 accgcattat tgaaaatgac ccccagctca tcctgaacgg tttgcagcca ctccaataac 2531581 atgtcgatca catggtgggg attcaagaag acaaggtatt ttttcaggct atcctcgcaa 2531641 agctccctga caataatatt tgcttcgttc aatccattgc tcaaggagat gcttcctttt 2531701 gtaatcgcct gttgaatcag cttctctccc tccccttcaa ttaacacttc taaagataca 2531761 tgcggagcat tgattttagg gtctttcgtt ccgactgtcg caaggatttc atactctttt 2531821 tcgatttctt ttatgctgtt ggccagctta atcgatgata cggtcaatat gtgaatgggg 2531881 gtatcggagg ccttgtttac gatcgtggtt agaatgtctt ccagcttttt ggccgttccg 2531941 ctacccgtcg tgcagatgga taccaatgcc ttctttttgc cggatgccgc tggctgacgc 2532001 tcccacaact cgataaaatc cttcgtgacc gattgataga tcgcatgcaa atttaaattc 2532061 aaatagttga cctttctgac agcatccagc accattgaag tcgtaacatt gctgatcgtt 2532121 ttaatagaaa tgcctgtctt ttcctccagc ctgctttcca gcattgcaag cgaccccata 2532181 tctaccagca ttaaaacacc ttcaccttca tcaacctgtt tcattttttc tgctacgcat 2532241 tcaagaatgt ccgaaggtga aacagtaagc ggcatgtcaa ctgctgcaat cggcgtactc 2532301 cctagcagtt ctgtcgcgac ttcaaccatt gaactcgccg tgctgtttcc atgagctgcc 2532361 acgataatac cgactctttt gttctccttt aacgatttga tggaatgaat taacatcgtt 2532421 aagtagatga cttctatttc aggaatagcc actttaaaat attcctgaat tttatcttta 2532481 aaaatcatcg ccacccgata ttctttcaca tgggtatcac gaatttcatc tgtctcctgt 2532541 gtattcaaaa catcaatttg ctttcctcgc tttaaaaatg cgtcaatatg catactcaag 2532601 aaataaataa acttacggtc aaatgtgcaa tccagctcat gttcagctat ttcttttaac 2532661 tgttttgtca tttgaatcac atcgtcttca acgaatgtca gcaggttgtc tttttgaaaa 2532721 gcttgatgat gaaaaaaact tctgacatgc aaatggacat cagtcaagat gtactggtta 2532781 atatcctttt tggataaacc ttctttcata agcgttttca ctttttcctc aatcaaatga 2532841 tataagttaa atgagaggtc ttcgtcaatt tttgttgttt catcttctac aatcggagag 2532901 ataatcgttg taatattgac atattcagaa atggctttgc ttctttgcat gtttttgctg 2532961 ctggacatcc attcttgctt gatttcatca ggcagatcgc gaacagtcag ttcaataact 2533021 tcatttctgt caaggttatg caaaaatccg tgtgcgcaaa ctaactgaac atttgatttc 2533081 agctgtccga cattcccaaa tttcgcagag tgaataagcg cattatagac atcgatatgc 2533141 acactcagat tcttcttaat tcgctctgct tctttcccta ataaaaacgt cgtcagatcc 2533201 actctttcat taagcgatcg ttcttcaagc gaaggaatat gaatggtcat tgggattctt 2533261 cgcaaaaacg ttttcaatag tgcagaactc ggattttctg tagtcgcaca aataaacaat 2533321 acgttcgatg ttcgtttatg ttcagattct ccaagcctgt tataagaacc gctgtcaata 2533381 aaataaaaca gcatttcttg tccctcggga gggagacggt ggatttcatc cataaaaaga 2533441 atgcccccat tggcctgttc gactaaaccc gccttatcct cggcagcacc tgtaaatgaa 2533501 ccttttttgt gtccgaataa ttgagaaagc aataattgag ggttgttgta gtagtctgca 2533561 cagttaaatg taataaatgg tgcgccggcc ttcaatatgt cagagtaaat ggcaaactgg 2533621 taaattcggt tcgcaaaaag ggatttaccg gaaccagtcg gccctaggag gagcatatgc 2533681 agaccgttcg gcggataaaa gacagctgct tttgcctggg agatcgcttt cttcaaactc 2533741 ccttttgccc ctatcataag ctctagggga ttcgtggaaa tgtgttgatg attttgcttt 2533801 gaatttccgg aaaacgcctg aaggtctttc acttccatca tctctgtatc ccatttcttg 2533861 ttgaataatt tttctgctat ctcgactggg atgtatctta caggaaatgt tttaattttg 2533921 atgacctttt tggaccggac gagattgttc aattcaaagc tgacattgga ccgctccatt 2533981 ttcagctgct cggcaatctc ctttgctgaa ttcccttgta tttttaaaag atgatctaag 2534041 gttgaatcat gaaaattatg cttgagctga tggtatattt tatctattct tctcacgtct 2534101 atcatccttt gtccttatta gataagccat taacaagaat atttcgaaac tttatagtcc 2534161 gcgttgagat ttacacgttt aaaaaggtct ctatagcaga ttgacaaagc tggcttttat 2534221 gcgtatatgt ttacatgttg aatcatttgc acctcatatt agtatgatag atgctcagtt 2534281 ctggagggcc agtccccttc aaaagtaata atcagtaaac agtttatcat tctcggggaa 2534341 tgtaatgatg tcaaaataat caatgacaaa aaatgaatct tatagatcat gacaaattac 2534401 ccaaatataa ccccttaagt tcgttcacaa ctaaaaagac ggacactcta tgtgaccgcc 2534461 acagtattac aatttgcaaa acttcgtcat ttttgcaatc cacattggag gttaaggaat 2534521 ctgtaagctt aaaaacttta tctccgatcc tatcgatttg atccccctgc cggcctcaat 2534581 catagtgggt atgcaattat acaaatcgtt accgattaaa actagcctgt cagattgtcc 2534641 aaatgacttt cctgttttac tctgctattc aggtagaatc acgagtgaaa aatagagcca 2534701 caagacatgt aacagcactt aaaatagttt taaaatttaa aaataaaagt atctattctt 2534761 ttaaatgtta taatatccga taaaacttta ctcatctttt tattactgga ggaaaataaa 2534821 attgataggc aattctagca aagacaattt tggccagcaa cagaaattgt ctagaggcct 2534881 taaaaacagg catatacaat taatggcgat tggaggtgca atcggtacag gtttattttt 2534941 aggttcaggt aaatccatcc attttgcagg accatccatt ttatttgctt acttgatcac 2535001 cggcgtattt tgctttttca ttatgcgttc gctcggagaa ctgctcttat caaatgcggg 2535061 ataccactct tttgttgatt ttgtaaggga ctatttagga aacatggcag catttatcac 2535121 tgggtggacc tactggttct gttggatttc cctcgcgatg gctgatttaa cggcggtcgg 2535181 catttatacg caatattggc ttcccgatgt gcctcaatgg ctgccgggtc ttcttgcgct 2535241 tattatcctg ctgatcatga accttgccac cgttaaactt ttcggagaat tagaattttg 2535301 gtttgcattg atcaaagtca ttgccatact ggctctgatc gtaactggta ttctcctgat 2535361 tgcgaaaggt ttttccgcag cttccggccc tgccagcctc aacaaccttt ggagccacgg 2535421 cggcatgttc ccaaatggat ggcatgggtt tatcctatct ttccaaatgg tcgtcttcgc 2535481 tttcgtgggt attgaacttg ttggactgac agcaggtgaa acagaaaatc cccaaaaagt 2535541 gatccctaaa gccatcaatc aaattcctgt ccggatttta cttttttatg ttggcgcact 2535601 tttcgtgatt atgtgtatct atccttggaa tgtgttgaat ccaaacgaaa gcccatttgt 2535661 tcaggtcttc tctgcagtag gcatcgttgt ggctgccagt ttgatcaatt ttgttgtatt 2535721 aacatcagcc gcatcagctg caaatagcgc tttattcagc acaagccgaa tggtctattc 2535781 acttgcaaag gatcatcacg cacctggact attaaagaaa ttaacttctt ctaacgtgcc 2535841 aagcaatgcg ctgttctttt catccatcgc cattctgatt ggcgttagtc tgaattattt 2535901 aatgcccgag caagtcttca cgctgattac aagtgtttca acaatatgct tcatttttat 2535961 ttggggcatc acggtgattt gccatttgaa atatcgaaaa acaaggcagc atgaagcgaa 2536021 agcaaacaaa tttaaaatgc ctttttaccc attatccaac tatttaacac ttgcatttct 2536081 cgcgttcatt cttgtcatat tggcactggc gaatgataca cgtattgctt tgtttgtcac 2536141 cccggtctgg tttgttttat tgattatttt gtataaggtg caaacccgca gaggacataa 2536201 ggtgaaataa aaaaaagaca agggatactc actcccttgt ctttttatat gtgtcaaaca 2536261 ctaaattaaa ctttggtttc aaatttcatt cacttcattt aagtgttaac tcaaaccagt 2536321 tttgatgccg aaacctacta atattattcc ggtaattttt tgaaacactt tctggaactt 2536381 cgagtttttc atccattttt ttgcgtaatc aataatataa acaagaaaca ggaaccacaa 2536441 caccgctaat aaggttagga ttgaagctaa aatgatgagc tgctggttta tatttccgtt 2536501 caaattgata aattggggca tgattgtaac atacaccaaa acagttttag gattgagaat 2536561 gttactgagt gatccctgca taaaggaagt tttataataa cgtttcggag aacttgccat 2536621 attttttgct tgggattgca tgtcatctaa cgaaaacata cttttagcaa aaaaactttt 2536681 tacacctaaa taaattaagt atgccgctcc caaatatttg atcgttgtga aaagaatcac 2536741 tgactttgcg attaccactg ataatcctaa aatggcaatc accgtccaaa aggaaagtcc 2536801 tgtcgccaat ccgagaatgt tataacggcc ggctttcgga ccatacctaa gcgtattttt 2536861 catcacaagc atcgtatctg cccccggtat gataaccatc atggcagcga tcggtatgta 2536921 tgcgagtaag ctgtgcattg ttctctcccc ctttaaaaat cccctcaatc atatagtgac 2536981 tacaaaagta actacttata aaagtgtatc aatgcgtttg gaataaatca atatgatttg 2537041 ttaaaatagc gattactaag gcagcgattg ctctttatat tggaggatat atgaaagaaa 2537101 atatgttaga cattttaaaa aacctcaatt ttacagaata tgaatcgaaa gcgtatttag 2537161 cattattgca agaatcacct ttaacaggct atgccgttgc caaaaaatcc ggagtgcccc 2537221 gttctaaaat ttatgaagta ttggaaagtc ttgtcataag gggagatgtt tttgtcagtc 2537281 atggaaatac gcctcagtat gttccagtcc ccgcaaaaga actgattaaa aaccgccggc 2537341 tcaaagcgga agagcatttt gatcaggctg agaaatattt tgaaaagttc gagcagaccg 2537401 caaatgaccg ggaaaacatc tggaatatca ccggccgcag tgaaattctt gaaaaggtga 2537461 aggcttgtat cttatctgcc aaaaaaagaa tcctcttaga aatatggaaa gaggatttta 2537521 aggagataga agcagagctc aaacaggcgg cagaacaagg cgttattgtc accattattg 2537581 cgtacggaga catcgtatct gattttgcca atgtttacct tcatgatatg agcagtgaaa 2537641 ttacagaaga gtatgacgga cggtggcttg tctatagcgg agatgattca gaagtagtag 2537701 cgggcattgt ctcacttggc aacgacagcc gtgctgcatg gacgatgcat gtagggttag 2537761 tcatgcctat tactgaagtg atcattcatg atctgtacct catggaaatt ctgaaaaagc 2537821 atagagagct tttagaagag agcttcggga aaaatctcat ccagttgcgc cgtaaatttt 2537881 ctattcactc agatttcaaa aaacattatt tggaataatg tttgtcatct cttaccccaa 2537941 aaacaaggct tgtacaaaac aagccttgtt tttttatgca taaacccccc atgctgattt 2538001 acttctctct tttaaaaaat gtgattctgc gcaaactatt tttcagcctg ccgcgtctat 2538061 cctaggtaac agcctacgat atacgtatat tcaaaaagga gccctttatt gcaatgaaga 2538121 aaaaacaaac aacaaaagcg ttgcttgtca catgcataac tgaccataag caagatttct 2538181 acaggttggc tttcagttat gtgaaaaatc aagatgacgc attagatatt gttcaggaat 2538241 ctataaaaaa agcgctgagc tcagttgaaa cggtcaggaa ccctgagacg ataaaaagct 2538301 ggttttataa aattttagta cggacagcca ttgacttttt gcgcaaacaa aaaaagataa 2538361 gagtgatgga cgacgaaacg atagaatttt taagcaaagg aaaggaagac cattacaagg 2538421 atactgatct ccatgaagcg cttgacgaat tgccgtaccg ctataaaacc attattattt 2538481 tacgtttttt tgaagacctc aaattagaag aaattgcgga aattacagga gaaaacacga 2538541 ataccgtcaa aacgcgccta tacagagcat tgaagctgat gcgcattcag ttgacgaagg 2538601 aggatctttc ttaatggata agagattaca gcaattaaga gaagaatata aaaatgttca 2538661 gattcctaaa gaattggata tcattgttga aaaagccctt cagcaagaac caaaaaagaa 2538721 aagaatcgtt atgtggccga catcagcagc aatcgctgca gctattttat tcactgcgct 2538781 tgttaatatc aacccggacg ccgctcaggc tatgtcaaag atccctgtca tcggcaaaat 2538841 cgtcaaagcg atcaccttta ttgaaatcaa agaggaaaaa gaccaatcaa gcattgatgt 2538901 caaaacacct gctttgtccg ggctttctaa taaagagctt gaaaacagca ttaacgagaa 2538961 atacttgaaa gaaagccagc agctgtataa agagtttata cagtccacat ccaaaaacaa 2539021 aaaagggcat ctcagcatct acagtgatta cgagacggtc acagacacgc cagatttact 2539081 ctctatccgg cgcaatattg aaacaacaca agcatcttcc tacacacaaa gccgttatat 2539141 tacaattgac aaaaagaatg atattttact tacattaaaa agcttattca aagatgagcg 2539201 ctatatcaaa gtcatcagtc aaaacatcaa agaacaaatg aaacagcaaa tgaaggaaga 2539261 tccaaataaa atatattggc tcactgacga agatgcagaa ccgttcaaaa cgattcttcc 2539321 tgatcagacg ttttacatta ctgaagacca taaacttgtg atctcatttg acgaatatga 2539381 agtcgccccc ggctatatgg gcgttacaga gtttacaatt ccaaccggcg tcatttcaaa 2539441 cttgctcgtg ggagaacgtt atattcgata aaataaaaac atccatctaa gattatggat 2539501 gttttctctc ttctctattc gaggtcgtaa ccccgctatc aaaaacaacg agaatatttg 2539561 catactattg gaggaatacc catgtatcac aagacacagc atcatcgata cattcctgga 2539621 cttgatggcc ttcgggcttt cgccgtcctg tcagttatca cttatcacct aaatttcaat 2539681 tgggctaacg gtggttttat cggggttgat atcttttttg ttttatccgg atatttgatt 2539741 acatctattc tattaccggc atatggaaat gatatcaatc ttgattttcg ggatttttgg 2539801 gtgcgccgca ttcggcggct tctcccggca gcgtacctta tgatcttttc cactgttgtg 2539861 tgggtcgtat tgtttgatcg agaactattg cacactgtac gtggagatgc gatctcttct 2539921 ctcttttata tgagcaattg gtggtttatt tttcacaagc tatcatattt tgatagtttc 2539981 ggttccccat cacctctaaa aaacctttgg tcgctggcga ttgaagaaca attttatatc 2540041 atatggccga tgtttttagt tgttggaatg tacataatga aaagccgcgc cagattggct 2540101 gcggtgatat cattgcttgt gctttgttca gccgtgatga tgagcgtact gtatgaacct 2540161 ggcggagatc cgagccgcgt ttactatggc acagacactc gttcgtttga acttctcatc 2540221 ggatgtgcct tggctttggt atggccgatg aaaaggctgt cttccaacag gctgccaagc 2540281 aaactgaagc acactttgca cgccactgaa tttttggcat tttgtatttt agtgttgtgt 2540341 gtctatttca cagatgaata cgagcctttt ctttacagag gcggaatgct attcattagc 2540401 gtgactgccg caatccttat tgcatgtgtt tgccatccga gcagcttttt aggcaatctg 2540461 ctttcatgga ggccgcttcg gtggcttgga acgaggtctt acggaattta tctttggcac 2540521 taccctgtta ttgtgttaag cacgccagtt caagaaatcg gaaaccctgt tttttggcat 2540581 atcgtgctaa aggtcattgt gacatgtata cttgccgagc tctcctacca ttttattgag 2540641 aagccgatac ggacacaggg atttaggtca ttttcccgcc gtgtttttat acatagaatc 2540701 aaggaatgga aaacgacatc tgtcatcagc aaaatgtcaa ttggtttcat tattttcgct 2540761 atacttattt ttgcaggcgg gctgtcaggg ctagccggcg agcaaaagca ccctaccaaa 2540821 tggacctata gctcacaaga aacaaatgct gacaccagcc aggcttctgg ggataaaaag 2540881 aacgctgcag cagataaaaa acacaatcct gaacaaaaga caacagattc caatcagggt 2540941 caaaaggaaa acaaagatag tgggcaagag actcataaaa agaaagacac gcaatcccaa 2541001 cagttgaaaa aaccagcaga cactgcgaaa gaagttttag ctataggaga ttccgtcatg 2541061 cttgatattt cttcacacct gcgtcagtca ttttcaaatg tgacgattga tggaaaggta 2541121 gggagacaaa tgtctcaagc tttggaactc gcaagggaat acaagtcttt taatcagccg 2541181 aacaaggctg tcatcattga gcttggaacc aatggctatt ttacaaacag ccaaatcgaa 2541241 caactgcttc aatctttctc aaaagctcat atttatcttg tcaatacacg ggttccccgc 2541301 caatgggaaa gcaaggtaaa tgaatctttg cagcaacagg cccacgcaca tcaaaatgtt 2541361 acgttagttg actggcatac agaagctctt cagcatccgg aatattttac ccctgatggt 2541421 gttcacttgg ttcctaaagg ggcaaaaact ttgactgctc ttattgttca ggcgatgaaa 2541481 tcgtaaaaaa gagatcctat acagatcact tttttacttt agtttctgat cgttgattat 2541541 gtcttctttc agcaaggcag cccttatgtt tacatgccgt ttacgtaagg gtaagccaaa 2541601 attgaatgga gggatgataa tgaaaggaaa tgaagaacat gacatccaaa aagagttgaa 2541661 acgatatgag ctttttttca aaaaacgata taaggttctt tatacagtaa acgattttat 2541721 catcggtgct atgtttctcg ttggaagttt tttctttttt tatgaccggt taatgtcggc 2541781 agggatatgg ctgtttgcga tcggaagttt gctgctgtta atcaggccga ccattcggct 2541841 gattcatgac tttcattacc gtaagcatgt ggaacagcaa ttcaagcatc aatcttcaac 2541901 agatgactga tcttaaggaa taagaaagaa caaaatgcca aaagcctgag tcgaaaatca 2541961 aaaacaagac tttcagacta tttattttta aaaacaaggt aaaaagaact aaacttttgc 2542021 ctctgcatgc cgatatgaat aataaggccg gcgcgatact ccctataaca tccttttcag 2542081 tagatttcat tatcgtgccg gttttctcat atgcaaagca atcccgccaa tcagattggc 2542141 gggattttat attttacatt cctgtccaaa cgtctttcac ataacgtctt tgatcttgca 2542201 gcttttgcag ccatacagct gattcttcct gacttgctgc tttttcagct tcatatgcca 2542261 atcgcaaagt tctctctaca tcaggagcca tttgcgatcc atcaccgcat acgtaaatat 2542321 gagccccttt ttcaatgagt gtcatcaatt tctgcgtatc ttgcttgagc aagtgctgga 2542381 catatccttt tggttcgttt tcgacgcgcg agtagcatcg gcggattgtg accaaaccgt 2542441 cctgttccgc ttgatccagc tcttctctgt aaaggtcgtc atggtccggg cggcggcagc 2542501 cgaagtataa aagtgcttca ccaagggtgc ttccttcctt cttcaaaacc gatcttgcct 2542561 gaataaagcc tctgaatggc gcaattcctg tgcccggccc gaccataatc ataggcgttt 2542621 caggatcatt cggcatctga aatccggact gcggcgtacg aatgaagcaa gctgctgcat 2542681 cacctgtatt caattctgct aaataattag aggcgacacc ccggtattca cctcggccgc 2542741 tccatgctga ggctttcaca actcctaccg tcatgctcac gatatttgca tgaactttcg 2542801 gtgagcttga aatggaatag tatctcggtt ttagtgatgg caaaagtgct aaaaaccgtt 2542861 caaacggcat ttcgcaagca ggataatcct ctaaaaaatc aagcatggta agacgttttg 2542921 caagtacctg ctctttgtaa atgccatcat ctgaaacgag ctgttccagc tctttttgat 2542981 gcggcggaca aactgtataa gaggccagct cccgaagctg aagccttgat gccggttcct 2543041 gcagctctac ataggacgac aataaatcca ctactttgat tggccgatcc atcggcagat 2543101 gagccatatg agcgcttccg cttactttta tcacatgatt ggactgcaaa ccgaatcggc 2543161 tgagaacccg ctgaacaagc tccctgctgt tctttggcag gattccgata tgatcgcctt 2543221 ctttatatgt tttaccagcc ggaatttcca attcaatatg gcgggttgaa cgcgtgctgg 2543281 cagctgtctg gagttctcga ttctctaaca caatcccttc aaacgcgcca tatgctttag 2543341 caaccggcgt ttccgtcgct tcactgagaa aagtaatcga taatgaaggc ctgtcttctt 2543401 tctgggctat ttcgttaata tcaaatgcgt ccatcgtttc cttccagaag cggttttccc 2543461 aagactcgcg gtggctttca aaatcatcgg cggcgtcacc ttccccaatc gctgttaaac 2543521 gcgatgcccc ctttgctttc atcatgtcat caatcaggcg gggaatccgc tgatacgtgc 2543581 tggcccagct ccggtttccg cagccgaata ccgcatagga aacacctttc aattggcctt 2543641 cctcaagctc tttcagccac tctacaaatc cggcagcatt atcaggcggc gccccattat 2543701 aagaagccgt tacaatgacg actgcccctt cttcagggag cttgccgata taatcatcaa 2543761 gcggagccgt ttcagctgta aagcccatct ggcggccttg agcagccagt tcaccggcta 2543821 ttccctcagc tgtcccaaga tttgaaccaa aaagaacaag taaaggtgtg ccgtgtttag 2543881 gtttggtttc ttttggcttt gtttctgctt tgatgtctgc ctgttctttt ctctgtacat 2543941 tgattgccgc tgtttttcgc ggtttcacag taattttaaa atcatccggc ttgatcgtta 2544001 atgcttcttt gatttttagt tcgtagccag tatggtttat caattcaaaa tgctttaata 2544061 caagaccgag aaccattgtc gcttcttgaa gagcaaactg catgccaata caagcgcgct 2544121 gtccgtttcc aaacggctta tacgcatggt gagggatact tgaaggatcc tcaaaccgtt 2544181 ccggacggaa atcttccgca tccggtcccc aagcgttttg atcccggtgc agttttggaa 2544241 ttaaaacagt gactggctgc cctttgctga tcggatattc cccgcctaga acagtatcct 2544301 ccttcgcata tagagaaaaa gccggagctg ttggatacag tctgagggtt tcatttaaaa 2544361 ccatccgaat gtatttgagc tgctggattt gtttatattc aggcgtgtca tccgttaaca 2544421 cgcgatccgc ttcctcctga gcttttttca gtttttccgg atgtgtaagc agacaataaa 2544481 tcgcaaagga tagcaacccg cttgttgtct catgtccagc aattaaaaat gtgatgattt 2544541 ggtatcgaat gttttcgtca tccagcgttt cacccgttac tggatctttg gcataaagca 2544601 tgagagacaa gagatcctta atgttttcat ccggattcgc ctttcgctcc gctatcattc 2544661 tatcaaccag ggagttcatg acttctatat ccttttggaa ctgcagcttc gttttcacca 2544721 tcattttatc ttgcaggccc agtcttttcg attgattcat cgcctctttt aaggcacgga 2544781 gcatactggt gataaacgga tgctgtgaat cacggtaaaa gctgttgaat cgatagttaa 2544841 acccgcataa cccaatcgta tcaagcgtca gacgtgtcat atcgtccgct acatcaattt 2544901 cttcattagg gtttaaccgg ctccactttt gaatcagctg ggttgcgata tccagcatca 2544961 tagaatgata gcctttcatc gctttttgac taaaactcgg cagcaaaatg cggtgggctt 2545021 tttgccagtt cggttcgtgc gtccagcttg taaataagcc atctcccccg aactcacgca 2545081 ccttttgcaa gcctttgcca aggttcttgt caaagcgttt ttcatcacac acttcagcca 2545141 caagattgtg gccggacaca aaaacactgg atactcccgg aaaatcaaaa cggaaaatcg 2545201 gtcccaattc atcagctatc cgccataagg attgagaaag ctgttctttt tccagatgcg 2545261 gaagattttt taaaggtccg tatgttttgg gctgaggtat tgcgcttgcc tgtttcatta 2545321 acatctccct ttcctatttt tgtgatgaat gaagcttaat ggcgtcccag cagcattgtt 2545381 ccaattcagt aattaaatca gtgtccatct ctatatcacc tgtttgaacg agctgatata 2545441 tcttgagaaa cgcccctaat acaatcgcaa ttaacacatt agagggcagg ctgcgaatca 2545501 cgccttccgc ttttccctta ttaaaatagt catcaagcat ttgagtcaga ttttctatca 2545561 tttttttgct tgtatgattt aagtaatgag cgtctttttt ggtttcaaga aaaaaaagcg 2545621 catagtcgct ctctttcgta aactgaacga gacagcaaaa tacgtggtga aagccttctc 2545681 tgacaggcaa ttctgaaacg tcttgcttca gtttttccgt aaatcgctgg atgctttctt 2545741 gaaacagtac gttaacgagt gtttctttgc tgtcaaaata acgatagatc gttcctgtcc 2545801 ctacatgagc acgttcagct atcataggaa tagtggtagc gtcaaaaccc ctttccgtaa 2545861 aaagtgagac tgacgctttc ataatcatgt cgtatttact gctggatgcg gatatcatgt 2545921 aatctgacaa cctccgattc gtttacggaa tgaatattca ttccttttgt tcacaaagaa 2545981 tgtctgccct gtctgatatc acctctttgt tctttcttct gttataagtt tatatgaaaa 2546041 aaactttttt taatataaag tatatgcaaa aaataaaaaa ttaagaaaat atacccaaat 2546101 cctaatacga ggatcttgga tatatttccc gagaaatttt ttatttaaca gccacaatac 2546161 atagacagga agcacgcctg ataacagaaa gatccctgaa atgctggtct ttcagcagtt 2546221 gaatatacgt tttctctttt tcaccggtat ttgtgtcaat actgatataa aaccggccgt 2546281 caatttgaag caccctgtaa atttctctta atgcaagcct aatatcggtg cagctttgaa 2546341 ccgtatgtaa agaaaagact ttattaaagg tacggtcatc aaagggaatg tcctctggat 2546401 agccatgaaa aacctccccg ttccccatgt tctttcgatt cgcacgtgat atctgtctta 2546461 cctttcgttt tgaaggatca atgcttttta ggctaccctt ttttagtttc ttggttatgc 2546521 ttttaaagac agtgccgttt ccaattccaa tttctaaaat tctgtcattt tcttgtatat 2546581 ctatagagtc aatcatcata tgctcaattg ttttggttag cttatatttc cgagaaaata 2546641 atttccaaaa atccgatcgt ttatagagtc tattttctag cattttaaac acctgctttt 2546701 ggtttcctat gtttatttat tatcttaaaa aaataaacat catcttcatt tctaaaagtg 2546761 aaggaaggta ccaactagac ggcaatgtat tgaaaaatgt ttcaatagaa ctaaactttt 2546821 tcattttttt ccgaaaaaaa agcagaaaac ataatgtttt ctgccctctt tctaatgcca 2546881 atgataaggg aatacataca gcctttgctg ctgcattgcc atcagcctct gctgtcggaa 2546941 tggatttcca taaccatgtt tgaaggaatg cggcatggac gcataaccat ggccaatcga 2547001 cggcagtctt ttttgataat cgttcatcat gccatcacct gcctcacaat aacgttgatt 2547061 tactatatgc aggcgcgcat tttcttgaca gctatttcgc taaacttggt ccttctccat 2547121 tgtataatgc atcaatagtt ccattctaag catatgccat tcccccttca gtttttttcg 2547181 ttgcttttag cgccagtttg ttaaataaag atgctttaac tgagactctt tcatttcatc 2547241 ataaatttgt tcaatctgct gttctcgttc gaattcttcc aggcttttaa accgtttttt 2547301 aatcgttaac gttaaaaaga ataggttaat cgtcatatcg ctcaccccct ttcaaagtcc 2547361 gcatcaagcg aaataacccg cggcacaacc cttctgccgc gggcaaataa aaaccgcaga 2547421 caaaagaaga caccaatgcc tctactgcct gcggggagtt gcgtatgtcc gactattccg 2547481 aatttaatgc gtgcgataag catcggttaa ggaaggacac gaactcttcc acaggctgaa 2547541 taaaccatga acttttacat gtgtatcacg tacaggttga cgtcgttgtc tcattgtcat 2547601 tttggttcag cctcctttgc ttttttctta ctttgtaagt atatccacca aattccattt 2547661 tgtaaacatc tttttctaaa aatggacgga aattgtgcaa atcatcgaat ggatttgccc 2547721 gttggtcatg acacctgctt catttctttt ctggagcggt ctttcttatg atatgcaata 2547781 aaataaatga gaccgacaaa tacagctccg ccgatgacat taccgataaa agccggaatg 2547841 atgtttccga tgaactgccc ccacgtgaat gagcctgcaa aaatggcagc aggaatcaca 2547901 aacatgttgg cgacaacgtg ctgaaatccg atagccacaa aagccatgat tgggaaccag 2547961 atgccaagga tttttcctgc tgcgtcttgg gcgccgaaag aaagccacac tgcaagacat 2548021 acaagccagt tacagccgat ggcggaaatg agaaccttgc caaagctcat atcaagcttt 2548081 ccttgggcaa cggcaatcgt tttttctaaa taaggacctg tttcagtcaa tccaaccaaa 2548141 tgcccgaaaa agtaagcaac aaacaatgcg ccgattaagt tcataattgt gacgattccc 2548201 cagttaatcg ctaactcttt tactgatatt tttctcgaaa ataacgccat cgcaactgac 2548261 atcatattgc ctgtgatcag ttcagcgcca gcgagaacga caaggatcag gccgactgga 2548321 aatactgctg caccaatcaa actggacagg ctcccccatt ctttcggaag atcgccaatt 2548381 accctgatat caagcaaata cccaagcgcg ataaatgcac cgcctaaaaa ccccagcaca 2548441 agcagtgacg gcagcgggag ctttattttt ttcatccctg cttcaattgc tgcttccgct 2548501 atttcatccg gttttcgaaa agccataata aaacgcctcc attacttctt cttttctcac 2548561 agttatgcaa gaaaggcaat aaaaaaggca gcactcaaat aacctgtgtc aaaccaggcg 2548621 tttgaatgct gcctaacttg tatgcatacc catacaacaa tatcaagcag tatataagat 2548681 attgaaagag aatatataca gttcgtgcat acattccatt gctttagcct tctataactg 2548741 tagcaacatc atatcaaatg tgacaaattt gtgtcaatga caaatatact agctttgcag 2548801 agcttctttt tgctcatcta tttttcggtc aaaaacaaat acagatacag cgatgttttc 2548861 ctcaatttta atatcagaaa acaaatggac tagcttagct cccataagtt cctccattcc 2548921 ttccggtgtt tgtttggaat aaaggtcttg aattaggctt gtccgggccg catgtaccat 2548981 ctctcttcct tcaggcgtgc gggcaataaa ctgctcgctt gcactcagat ttccgtatag 2549041 tgttgaaact gccatgtttt ctacaaatac agtatgaatt ctctcaggcc cttttccgaa 2549101 caattctttg cgaagttttc gaataatatc attgaattca tgaatttttt tagacatgct 2549161 gattacccct tccgatattg ccttataaag gcttttcccg gttcccctca ggacatttca 2549221 cttggttaaa attttcctgc catattgtat tataataaat atcacattat aataaaagca 2549281 gtgttgatgg atttgtaata ggatcttgtt atgagtctat cgttttataa aaatcaagga 2549341 ttggtctgtt agtaagactt gctagtgaac tattccgcca tgtgtgttta caccttctta 2549401 gaattaaggg caggtgtatc tatacatggc tttttttgac ttcttgaaag aaagatggag 2549461 gggaatatga atatgatgga cgttaagtcg atcagtgtcc gtgtagacgg aacagaaatt 2549521 caagcacgag caggggccac aattttagat attttaaatg aaaacggaat tgagtacccg 2549581 cagatttgcc acgtaccaga ggttgacccg attcaaactt gtgatacttg catagtagag 2549641 gcaaacggca agctggttcg ttcatgcgcg acggttgcag aaaacgggat gtctattgat 2549701 ctttcaggaa atcgagtgaa agaagcgcaa accgaagcga tggaccgcct tcttgaaaat 2549761 catttgctgt attgtacagt ttgcgataac aacaatggaa actgtacgct gcataataca 2549821 gcggaaatga tggggatcga gcatcaaaaa tacccataca cgccaaaaga agatccttct 2549881 tgcgcggttg atatgtctca tcctttttac cgctatgatc caaaccaatg tattgcctgc 2549941 ggccagtgtg ttgaggtctg tcaaaacctt caggtaaatg aaacactctc aatcgactgg 2550001 gaacgcgaac gccctcgcgt catttgggat gagggagttc cgatcaatga atcttcctgt 2550061 gtcagctgcg gtcagtgtgt aacagtatgt ccatgtaatg cactgatgga aaaatcaatg 2550121 ctcgggcagg ctggttttat gacaggcatt aaagaggacg tcatggaacc gatgattgat 2550181 ctcgtgaaaa atgttgaacc ggggtatggc agcatttttg ccatttctga agtcgaagcg 2550241 gcaatgcgtg aaacgagaac gaaaaaaacg aaaactgtat gtacgttctg cggtgtcgga 2550301 tgttcatttg aagtatggac aaaaggacgg gatattttaa agatccagcc tgtttctgat 2550361 gctccggtta acgcaatttc cacatgtgtc aaagggaaat tcggctggga ttttgtcaat 2550421 tcaaaagagc ggatcacaaa gcctttaatc cgtaaaaacg gagcctttgt ggaatcttct 2550481 tgggaagaag ccctcgatct tgtcgcaagc agattaggat caattaaaga gcagtacggt 2550541 aaaggctctg tagggtttat ttcttcttct aaaattacga atgaagaaaa ctacgtcatt 2550601 caaaaactag cgcgtcaggt atttgaaaca aacaacgtcg ataactgctc acgctactgc 2550661 cagtctcctg ctacagacgg attgttccgc actgtcggca tgggcggtga cgccggcacg 2550721 attaaagata ttgccaaagc aggcctggtc atcattgtcg gtgccaatcc ggcggaagga 2550781 cacccagtgc tcgcaacacg cgtcaaacgg gcacacaagc tccacggtca aaaactgatt 2550841 gttgctgacc tgcgtaaaaa tgagatggct gagcgatctg atctgttcat cagccctaaa 2550901 caaggcacag accaagtttg gctgatggct gttacgaaat atatgatcga ccaaggctgg 2550961 cacgatcagg cgtttattga tgagaacgtc aattactttg aagattataa agaaaccctt 2551021 aaaacgtata cgcttgatta tgcagaacgc atcacaggcc tttcaaaaga aaacatcatt 2551081 caaattgctg aaatgattcg tgatgctgac ggcacttgtg tcctttgggg aatgggtgtc 2551141 acacaaaata caggcggttc tgatacatca gcagccattt caaacctgct tctcgctacg 2551201 ggcaactatc gccgtccagg tgccggcgct tatcctctgc gcggacacaa taacgtgcaa 2551261 ggcgcatgtg atatgggaac attgcctggc tggctgccgg gatatcagca tattacagat 2551321 gacaaagcac gcgctaaatt tgaagaggca tatggtgtcg agattgatgg aaagcctggt 2551381 ttagataata ttcaaatgct tcatgccatt gaagaaggaa aaatgaaagc tatgtatctt 2551441 gtcggtgagg atatggcact ggtcgattca aacgcgaacc atgtgcatga tattttatca 2551501 agccttgatt tcttcgtggt acaggacatc ttcctgtcaa gaacagctca atatgctgat 2551561 gtcgtcttgc cggccactcc ttcacttgaa aaagacggaa catttaccaa cacagaacgc 2551621 cgtgtccagc gattgtatca ggcgcttccg acgcttggtg acgcaaaacc ggactggtgg 2551681 attattcaag aggtggcaaa ccgtttagga gcgaattgga attacagcca tccaagtgac 2551741 attttctctg aaatggcgag tctttctcct ctgtttgcca aagcaagcta tgaggtgctt 2551801 gaaggctgga acagcttcct atggggcagc ttcacaggtg aaagcacacc gcttctgtat 2551861 gaagacggat ttaatttccc tgacaaaaaa gcccgctttg ccctttctga ttggaccgag 2551921 ccagcggcat ttccggagga atatgacctt catatcaata acggccggat gctggagcat 2551981 ttccacgaag gaaacatgac aaataaatcg aaaggcatcc aagcgaaagt gccgaatgta 2552041 ttcgttgaga tctcacctga gcttgcacaa gagcgaggtg tttgtgacgg ttcgcttgta 2552101 cggctcgttt ctccgttcgg agcagtcaaa ttgaacgcgc tgatcacaga ccgggtacgg 2552161 aaaaatgaac tctatttgcc aatgaactcg acagacaagg agtcagcgat taacttcttg 2552221 acgggccctg cagctgataa acggacgaac acgcctgctt ataaacagac aaaggtccgc 2552281 atggaagtgc ttggcggctg tgaaacagcg ccgcttccaa aaacaaatcc gcgcaacaaa 2552341 aaacggcatc cgcaaaacgg agtcgaagca gaaagaaaat ggaaccgccc tggctatgta 2552401 catctgactg attaaacgat aggaggaaaa cgaatggcca ctccgattac gacgatcaaa 2552461 aaagaaacaa aaacagctga gcaaattaag cttgaaaaaa tagaagaact gaaagagctg 2552521 ctggcggaaa atgaggacgc cgtctctaaa acgatgacgt taatgaatga actcaatgat 2552581 cttggaattt ttgatgcggc aacaagcatg ctcagagcga aggaagacat tgccaagatt 2552641 gcgcttggcc aagtttcccg cgagcctgtc accaacctca tcaacacgat gatggccgcc 2552701 ggaggcgcat tgacaaaagc cgatcctgag tttacagcaa agcttttaga aagcgtaatg 2552761 gctgggactg aacaggcaca aagcttttta aaagaagaca agaaagtcgg gattctcgac 2552821 ctgttaaaag caatgaacga tcctgacatc aacagagccg tcgggttcgg ccttcagttt 2552881 ttaaaaggca tgggaaaaga acttcgagaa caataacaga aaaacagcca tctctgatga 2552941 tggctgtttt tttattcgtc ggcttcttcc agacgcttct tgtaaataag tgaacggtca 2553001 gcgcaaaaga aggcaccggc taaaaatacg caatccgcta aaaacatcgt cgatttctgg 2553061 cctaatgtta agccttgatc agggagaact gcgcctatat ataaaaaagt gctgactgca 2553121 agcaatgtaa aagcaaaatg cttgtagtct tcttttaaag atttcattct atttttgttc 2553181 aaaagaatca cctgccagat tcatagtata cgactattat aatataatcc ggcggcttac 2553241 agagaaagta attctatcca tttgttatat attttcaagc gcttggccga tatcttccaa 2553301 caagtcttcc gcatcttcaa ttcctacaga aattctgatc aagccgtccg taatgccgag 2553361 ctcaagccgg cgttctctcg gaatagaggc atgtgtcatt cttgcaggaa cagaaattaa 2553421 gctttcaacc gcccccaggc tttcagcaat ggtaaacagt ttcagatttc ctaaaaacgc 2553481 atcaacccgt tcttcactgc caatatcaaa ggagatcatg ccgccgaagc ccgctccttg 2553541 cgtttttgca agctcatgtc cgggatgatt tgaagaacca gggtaatata acgtttggac 2553601 agcagggtga ttctcaagaa agcttgcgat tttccgcgca ttttgatcga tcgcttccat 2553661 tctgagtccc aacgttttga ttcctctcat taacagccag gaatcttgag ggccgagcac 2553721 gccgcctgtg gagttttgca caaaatgcag ctcttctcca agctctttcg aagctgtcac 2553781 aactaaacct ccgacgacat cactgtgtcc gccaagatat tttgtcgcac tgtgcagtac 2553841 gatatcagcg cctaaagtaa gcggctgttg aaaataagga gtattaaagg tattgtctac 2553901 gataagcaga acacccgctt tttttgcgat atcagccatg agcgtcaggt cggtgatttt 2553961 gagcaacggg tttgtcggtg tttcaatata aattgctttt gtattagggc gaatcgcttt 2554021 ttcaacttct tccctgctgc tcgtatcaac aaatgttgat tcaatgccaa gacggttaag 2554081 cacctttgtc atcacgcgat atgttccgcc gtacacatca tcagtcaaca cgacatgatc 2554141 tccgctgtta aacagcatca taaccgctgt aatggcagcc attcctgagc tgaacgcata 2554201 gcctgcttcc ccgctttcca gttctgtcac aagtgcttcg agagcggttc gagtcggatt 2554261 ggccgttctt gaatactcgt agcctgtatg ctgccctgct ttcggctgct tgtacgtgct 2554321 tacttgataa atcggcacgg aaactgcgcc tgttttctca tcacctgtga ttccgccatg 2554381 tatcatcaat gtttttttct tcatatcaga tgcctccttc gtatatttgt ttgctgatat 2554441 atcgatcgct gctgtcagga aatactgtga caatgttagt tccagcggat gcttttttcg 2554501 cttcctccaa tgccgcataa agcgctgcac ctgaagagct tccgatcagc aggccttctt 2554561 tttctgccgc ttctttcaca agtctaaacg cattctcatc tgttacggtg tagatctcgt 2554621 caaaatggct cttatccata taatcgggga taaactccat gccgatgccc tctgttttat 2554681 gagcgtgggg ctctcctccg tttaaaatcg agcccaccgg ttcaacaatc accgttttga 2554741 ctgctggatt tttttctttt aagaaggaag ctgtccctgc gaatgtgcct cctgatcctg 2554801 cccctgcgac aaatgtatga atattcccgt caagcgcttc ccacatttca ggtccaagcg 2554861 tcttatagta agtcgatgga tttactcggt ttttaaattg caaaacgcaa taagaatttt 2554921 caatttcagt ctccagctga atggcttttt gaatggctcc ctgcattccg tcttgacgcg 2554981 gtgtatgaat gattgatgcg ccaagcgctt gcataatttg ctgtttctct ctgctgaaat 2555041 gttcagggac acagaaaatc gctttcagcc catattttct ggcacttaac gcaaggccga 2555101 tccctgtatt gcctgccgta gcttctataa tcactccgcc gggtttcact ttgcctgaat 2555161 cgagcgcgtc acgaatcagc atatctccca gtctgtcttt gatgcttccc cctggattca 2555221 tcatttcaag cttggcatac accgcgactc cttctggaac atcaaagttc ttcaagcgga 2555281 gaagcggtgt attcccaatc agctcggtaa tgtccgtaat cactgtcata tatgtcctcc 2555341 tccttaatag aggttgtttt tagagaaaaa cggaggagaa cgttctcccc gttttaatga 2555401 attcgtttga tcacctttaa cacaagctct gttgaatgaa cagccgcctg ctctaaaaat 2555461 tggtcaaatg aaacatgtga ttctttgcct gcgatatctg ataacgctct gatgacgaca 2555521 aacggcgttt taaattgatg gcatacttga gccactgccg cagcctccat ttcaaccgcg 2555581 tacagatcag aaaatctcgc acgcacctct tcaacccgct tcggatcgtt catgaaagaa 2555641 tcgcctgttg caatcgttcc ttttgcaacc tgaatgccgt cgagttcaga taccgcttct 2555701 tcagtgatgc tgatcagctt ttcatccgcc gcataagcag ccggaagacc cggcacttgg 2555761 ccgtattcat agtcaaaagc cgttacgtct acatcatggt ggcgaacgtc agtggaaatg 2555821 acgacatccc ctacattcaa tgtatgatga aatccgccgg ctgagcctgt gttaatgaca 2555881 taatcaggct tgtaacggtc aagcagaagc gtcgtgctga tagcagcatt tacttttcca 2555941 attcctgatt ttaaaagaat cacttcagtt ccttcatatt cgcctgttgt aaattcacag 2556001 tgtgcgatcg tttctgtttt tgcattttca agtttgtttc ttaagatggt aacttcctct 2556061 tccattgctc cgatgactgc tagtctcatc tattcacatt cccttcactt taccgtttga 2556121 tcgcctccat tatccacacg aagtcgtttt gctgagtgaa tcggactgca aaaccttcag 2556181 ctgtaaacat ttctttcaac gcatccaatg taggataatg ctctgtctct aaatcatttg 2556241 caagctgata aaagccttga gaacgggctt tatcgatagc ctgttgatac gcttgcgcat 2556301 tttcaaagac ggtatcggca aacactattt tatcatgcaa gtgaaggtat ttgccatatt 2556361 gctttatggc agcccgcttt tcttcgtcag tcaaatgatg aaaagcatat gaactgacaa 2556421 tcgtatcagc ctgaaatggc ggctcaggga atgtcaggaa gtctccatca acgatttccg 2556481 tcctgcctga gagcttgtca gaagccagtt tacgcattgc tggagaaggt tcgattccaa 2556541 atacagtttt gcctgcatcg agcagcttag ctgtcaaatt cccggtcccc gggccaaatt 2556601 ctaacacatg cgttccagat tttctgacga tggcatcaag gatatgatcg tagcctctga 2556661 acgcttcttt atactgaata tctaaacctt gtactgtttg atcataagtt gctgcccaat 2556721 cttcaaagag agggataaat tcacggccca tatttgtcac actccatatt taataattcc 2556781 tataagtata ctatggatta atgatggaac agttcctata ataccacata ttctgaaaag 2556841 caggtactaa aacactttgt gtattttatg ccatctcata ttgcgcattg accgcaaaaa 2556901 agcttatact tcatatgact tgtgaaagct ggagggtcaa gacatgaatt ttcaattaga 2556961 tctgattaaa gacaaagtgg aattttttga agcggcttca ttgcaggagc ttgaaaagaa 2557021 aatcaataca caaattgaaa acaataaagc catcatgctc cgggtgaaat ctgtttcaca 2557081 ccaaactctt gtggcagaag gaagaatatt gtacagcgcg gtggttcatt tctcagctga 2557141 agcctaaaac aaaagcagcc ggttttaacc cggctgcttt tgtttatttt agcttttcta 2557201 cttttgtcgg cttccagcct ttttcatcga cccatgtaat cgtgacttga tatttattcc 2557261 cagtcgcctt gtccaaaatc ttgcctttgg catcctgagg gctgccgtta tttccaagcc 2557321 agagcaccgt catgttatct gttgagacac cagttgcgta cgaaatggct ttcagcatct 2557381 cagcccagtc ttgtgagctt gaatcataag tagcggcatg ctcgccagtc tgctcagttc 2557441 cgactgcttt ccagtcagga ttttcatacg ttttttccac atcgctcgat gagccgcctt 2557501 ctgttacttt tgcatcttta agcccgtcac cggctgaatc tgagcttgaa tctgaatcag 2557561 agtcatcttt tttagaagaa gaatcatctt ttttggaatc agagtcagaa gacttctcag 2557621 aatccttttc gctgtcagat gtatctttct tgctgtcttt tatatcctca tccgatttct 2557681 tttccgtctt tcctgaagcc ggagattcct gtttttgcgc cgtttcagaa tccttgctga 2557741 catctttgct agaaggactg ttaatgaaga gattcgctgc tactacgaca attagtatgg 2557801 atacgattgc gattaaaatg ttaagcacta aattggcttt tctgcgttta tcacgatttt 2557861 cataacgaga ttgattattg ctcaataatt ctgcactcct ttatccctct tggctcagca 2557921 tatattttaa catgtgctga gaagttgttc tatttctgat tgatttcaat ttcgtgtact 2557981 tttttaacaa tatcataaaa caccgaattt gtcagagcct tatctcccgg tgtatccatg 2558041 tgtaaaacaa ctagagcgta tttcggctta tccgcgggaa aatatccggc aaaccatttt 2558101 tcgtagagcg tttccttctc ttttgaaagc ttgcctgtct gggctgtgcc cgacttccct 2558161 gctacagtat acggaagatc ttgaaacctt ctgcccgttc cggaaggaga ttctactacc 2558221 cgccgcagta ttttttgaag ctgctgtgac gtatatttgt ctatcgtttc ccctttgagc 2558281 ttctgatctt taaacgtaac gagcgttgtg ccgttcttat actcaatttg ttcggcaatt 2558341 ttcacctgcc gtttttctcc gccgcgggcg attgtcgcca tcatattggc tacctccagc 2558401 ggcgttacct ttacattttt ctgcccgatt gctgtttgcg caatggcttt tttgactgat 2558461 ttgtcttttt catcccccca aatcacgccg cttttttcgt tatacagctg gcggaaatcg 2558521 gtttcgtggt acagttttcc ctcccagcct gcccgatcag tgagagccag cttctcggac 2558581 atatcttcaa taaccgagct gtcttttttc attaattgtt ctgcaagact cgtaaatgtg 2558641 taattacagc tttgggcaaa actttcatca aaagacaagg tgcctttgtc gtcccccggt 2558701 tccccgtaca ggtttaaatt gcaattaaag gtttgactag gcttcaccat attattttcg 2558761 attgcagctg cggcaatgac tgttttaaaa actgatccgg gatagattgg cgtcagcata 2558821 taattttgaa gtgtgttttg ccgggacacg tctgcatctg gtttgcttac aattcccaga 2558881 acactgctat tttcgatgtc cagcagcaca gctcctccct ttttcagccc ctgttcatcc 2558941 aatacctcct ccatcgcttt ttgaatgctt tgatcgatcg ttgttttgat ctggagcgga 2559001 taaaatgtat tggcttcagc tgtatatttg acgtccatgc caaacaaagg gtttcctttt 2559061 ccgtccacat gatataaaag ctttgtgtct tgttccggaa gcaaaaactc gtcaaatgtc 2559121 cgttctaaac cggttgttcc gatttctgtt gtaatcggaa ggctctcctt gtcaggatat 2559181 ttcttgcgaa gcagcgccgg atcttggttc gtgctcccta tcgtatgtga agcaaggctg 2559241 ggcttgtctt cattctccat atatacgccg taaatgccgg gatatttcaa agaattgatt 2559301 tttgtgatag attgttttga aagtgttttg attttctttt gctgcaaaat gaccggtttt 2559361 tttgcctgac ctagtgtctg gcgcaaatca tcttcagaca tgccgaggat gtccgcaact 2559421 tttttgatcg gccaatcctg cgtcagcaga aaagggaaca aaacaaccgc aggctcgctt 2559481 tgtcctgtca gcgcccgccc gtttcgatct aaaaaagagc ctcttccatc tgaaatgagc 2559541 acttcctccg tccgctgttt cacactttct tgaatcaaat taattttctt tttagaaaat 2559601 gattctgtga aaaacagctg gatttctgca agtctcagca gaagcagaaa aaatacaatc 2559661 aaaaaagcga tgactgccag cttcattcgt ttcgatatct tcataaaaaa acacctcacc 2559721 cacattgtgg acgaggtgtt tcgctgctaa acagatatta tgaaattttc acaattttca 2559781 cgagcatttc tccgcccggt gtttgtactg tgacttcttc atctactttt ttgcccaaga 2559841 ggctttttgc gatcggtgaa tcgtttgaga ttttcccttc aaacgggtca gcttccgcgc 2559901 ttccgacgat cgtatatgat tcttcatcac cgtcaggcag ttcgacgaaa gtgacggttt 2559961 tacccaaacc gacaacgtta gagccgccgt catcttcaat gattttcgca ttgcgaatca 2560021 tattttcaag agtcgtcacg cggccctcta caaatgcctg ctcttctttc gctgaatcgt 2560081 attcagagtt ctcggaaagg tctccgaagc ttctcgcaat tttgattcgc tctactactt 2560141 cttttcgttt aaccgttttc aaatattcta attcttgttc aagtttttgt tttccttctg 2560201 cagtcatagg aaaaactttc tcttgtgcca tgtcccttca ctccttctgg ttgtccctca 2560261 acatcttcga ttatgtatga gagcataaac taaaaaatac aagaatgaga acacagggca 2560321 gtcctcgttc ttctctccca tataggtact gtttatctta aactgaatcg tgtcgttctg 2560381 caaatatttc gcgtttataa acagggaaag aagggaattc gcacattccc ttcctgccta 2560441 tacataatat ggtcagagtt atttatgtct atgctatggt attacaaaat cgcgttttgt 2560501 tcaagaatgg tttgaatttt tgtgaccatc agatcaattg cgacgtgatt ctgaccgcct 2560561 tccgggataa taatatcagc gtatcgtttc gtcggctcga cgaattggtt atgcatcgga 2560621 cggaccactg acacatattg ttcaatgaca gaatcaatag agcgtccgcg ctcattaata 2560681 tctctcataa tccgtctgat gatacgcaag tcagcgtccg tatcaacata aagcttgata 2560741 tccatcagat cacgaagcct tttgtcttca agaacaagaa tgccttcaag gataataaca 2560801 tcctttggct ctacgtgaac cgtttcttct gaacgtgtgt gaagcttata gtcataaatc 2560861 ggcttttcaa tcgggcggta attcaataga tcttgaatat gctcgattaa atagtcatta 2560921 tcaaacgcaa gcggatgatc atagtttgtg ttcagccttt cttcaaacgg aagatggctt 2560981 tggtctttat aataaaggtc ctgctggatc attaaaattg agtgtccttt aaactgttca 2561041 taaatggacc gtgtgacact cgtttttcct gaaccggaac ctcctgcgat tccaatgact 2561101 actggattct tacccatggg ctgttacttc ccctttctca tcatgttgct cggataaatc 2561161 tttttgtcta gtttgaattt gacaatttgc aggggatggc gggcagcatc tagctcattt 2561221 ccgtcttcgt cccaaatggt ttcaatcgta tgtgtaaagt tttcgatttc tggaccgaaa 2561281 aattccactt cgtcgccttt tttgaagaaa ttgcgctgct gaagcgtgac catttgtgta 2561341 tcttcatcat aattcagcac taagccgaca aaatcatatg tcgttttctt ggcgtgttcg 2561401 ccgaacattt gctcttcata gcctggcgtt ccttcaaaga aagctgtcgc agtgtccctg 2561461 ttggcgcact tatcaagctc ttcaagccat tctttttgaa tcacaaagtt ttctggatca 2561521 gcgcaataag catcgattac tttgcggtat acgctgacaa cagttgctac atagtgaatg 2561581 gatttcatgc ggccttcaat ctttaagctg tcgatcccca tttcaatcat ttttggaatg 2561641 gattcaatca gcttcaaatc tttcgggctc atcgcaaatg gtgcatcttc ttcaccatac 2561701 aaagcaacgg cgttggcacc gtctgtttgg tagagatcat aatcccagcg gcatgactgg 2561761 cagcagcctc cgcggttgga atcccgcgct gtcatgtgat tgctcagcac gcagcggccg 2561821 gaatatgcaa tacacattgc gccatgaatg aaggattcga tttcgatatc taccttttct 2561881 ttcatttctc tgatttcaag agcgctagtt tcacgtgcca gcacgacgcg gtcgagacct 2561941 tcttccttcc agaactggac agccttccag tttgaaagag actgctgtgt gctcaagtga 2562001 acctcaacat tcggcgccac tctgcggcat gtttcaataa taagcggatc tgccacaata 2562061 ataccggcaa cgttggcgtc tccaagcgct tttaaatagt cttcaagccc gtccatgttt 2562121 tcattatgag cgaaaatatt cgttgttacg tagatcttcg cgccatattt ctttgcgaat 2562181 tcaacgcctt ctgcaatttc ttcgatcgta aagttatcgg cattcgagcg aagcccgtat 2562241 tcctgtcccc cgataaagac cgcgtccgct ccgtaatgaa cagcgatttt cagcttttca 2562301 agattacccg caggtgcgag aagctccggc tttttcgtaa tcacacgctt tccattaacg 2562361 attgtggata ttttatcatt tacggcagtc atagcttaac ctccttttga ttaataaacc 2562421 gtttccttga agaagaatcc ggtatcaatt tttctgttta ctggctggat gctttcaatg 2562481 cgttcgatcc agtcttcttt tttcgcttcg tattcgtcac ggttttccac gcacaaatca 2562541 attgcttctc tgtacatttt ggtgacttct attaggtatt caggcatttt caaaacacca 2562601 tcgattttga aagaatcaat tccggcatct atcaattcct cgagctcatc aatgatgcac 2562661 acatcgttcg ggctcatgat gtgagtgccg ttttcatctt cgaaaatcgg atatttatta 2562721 tcgcgttctt tatcgtgtaa aaacatgcct gattcttttt tctttctttc aatgtccatg 2562781 actttgccct gatattcaaa atagtttcca atcaaagaac gcttcgattg gaacatgcac 2562841 gtcattccat gcacctggat ttcaatttcg acttcagcat tttctttaat ctcaacaatg 2562901 ctgtccatgt ttaattctct ggcaagcaca gaacgcgccg cacccttgcg tccccagtag 2562961 ttgcatgtat aatagttggt gcctgtcgtt tctgtgctcc aatgaagctt cagatcaggc 2563021 gcagattcac gggcagccat cagcacggca ggatcgccga ataccgctgc atcgacaccg 2563081 gcttctgcta agaaagccag atattcgcca agctcaccca ctttatcatt atggaaaatt 2563141 gcatttacag caacgtatac ttttgcccct tctttgtgag caatctctac ggcttttgtt 2563201 acatcttcac gagaaaattc tccggctaat ctcaagccgt atctctgttc cccaactaaa 2563261 aacgcagttg ccccagcctg tatgagcggc aaaatgtccg ctgtactcgt cggcgtcact 2563321 aagagctctg gttttttcat gacgttcacc tcttcttttt actaatcgca agtccgtccc 2563381 cgacaggaat aatcgcagtt tgataatccg gatgattcat cagccaatga ttatattcat 2563441 caattttggc tacaagcctg cgccttctct tcggttctat tttgctgtaa tcctctgcca 2563501 ccagaccttt aaacagcacg ttgtctgtta taatcacccc gtccggtgaa agcatcggtt 2563561 catataaatg aaaaaagttt tgatactgac cttttgcagc gtcaataaaa atgacatcgt 2563621 aaggcgcggt tacatgaacg gcgtcggcta attcaagcgc atctccgtaa aaaacatgaa 2563681 tccggtcatc aagctgaaat tccttgatat tgtttaccgc ttcttcatgc cgtttctcat 2563741 tgcgttcaat tgtatatatt tcagcagacg gcagttccag agccattcga atggctgaat 2563801 aaccaatggc cgttccgatt tctagtattt ttttcggctg tttcacagac aaaatttgaa 2563861 gcagcacctc catgcccgct ttttccataa tcgggacatg atgttcttct gcatatgctt 2563921 caagtctctt cacgttatcc ggccgaggct ttaataatgc ttctatatag tcatttattt 2563981 gttcataccg gtcagtcact acaaacagcc tcccgttcta aaaaggagtg ccccagtctt 2564041 atgcgcagga cactctctga atacatcatg atacatcggt aaacaacccg atatatttta 2564101 tcataaaacc ttgcggaaag cgaacaaaag gagagctttt tgctctcctt ttatttctca 2564161 ttttttgagg aaatgtattt ttcttttgct ttattatgct cttttagcgt ttttgtaaat 2564221 acgacctcac catttgattt ggccaagaaa tacagatagt ccgttttatc cggatgcagc 2564281 gctgcttccc atgatgacat gccggcattg gcaatcggcc ctggcgtcag ccctgtgttt 2564341 ttatacgtat tgtatggtga atcgatttcc agatccttat aaagaacccg atctttatgc 2564401 ttgcctgccg cgtacaggac ggtcggatct gtttggagcg gcattttctt tttcaggcgg 2564461 ttataaaaga cgctcgcaat tttatggcgg tcggcttttt cagtcgcttc ttcttctatc 2564521 aaagaagcca ttgtcagcag cttatgcaca gaaactttgt ttttcttcat ttctgattta 2564581 tatgtttcca cataagaatt tgtctgctta atcattgcct tgataatgtc ttcaagtgat 2564641 gtgtccggat cgttaaaagg gtatgtagcc gggaataggt acccttcaag cgggtgctta 2564701 atgtttttat tgaaaacatc atttgtcaca gtgtccggga attctttctt cagctgattg 2564761 ataaatgttt catcgtccag cttcgctatg acttgttttt tagagtattt tgtttcatca 2564821 gcaatagcag ccgcgatttg ggtcagctgt gctccctcag tcactgtgat ttgaaaagcg 2564881 taacctgtag ccccgcttgt cagcttctga ataatggcat ctaaatccat acctttattc 2564941 agatggtaga atccggcctg aaacccggaa gcacctttat atttcacata gtactgaaac 2565001 gccttctcgc tttttatgac atcatttttc tttaatatcg atgcgatggc tgaaacagac 2565061 gaaccgctcg gaatgttaat attaactgtc gttttactgt ctttttcaac aggttcaagc 2565121 aatgatttcc catataaaaa tgccccgcca atgatgagaa acagcacaac aatggaagac 2565181 agtatgattc tttttttatt aaaaaacgat tttttttgct gattgatata cattaggtct 2565241 cctcccatca gctcttatac tacatgattc attgtatttc ggcaatttat tacaaaaaga 2565301 ggcctgcata aagcagaaaa aagccggagc agtatagctc cggctttggt ttggcgcgat 2565361 gttttactct tcgtcttcgt ccgctaagaa tgtgtttagt gtttcttcga tcatatccca 2565421 ttcttcgtca gtttcaatcg ggaatagctc accgttttca ccgtcttcgt ttggcgtgaa 2565481 gctggaagca agaatttcta cttcttcgtc atcttttgat tcgattggat agtacaagac 2565541 ataagatttg ccaaactctt cattttcaaa tgtaaacagc acttcacaaa gctgttcatt 2565601 tccttgatcg tcaacaattg taatattttt ttcgccgtgt tccattttct tcacctctgg 2565661 ctttaattta agctgtcaag atatccttgt aaaatcataa cagccgccat tttatcaatg 2565721 actttttttc gtttttgcct gctgacgtca gctgcaatca gcattttttc agccgccatt 2565781 gtggtaagac gctcgtccca cagcacaaca ggaacattgt acgttgtttc aagcactttc 2565841 gcaaatgttt ggctggcttc gcctctcggg ccgactgttc cgttcatgtt cttaggaaag 2565901 ccgagcacga ttttatctat agtatagtcc tttatcagtt cagataaacg ggataaacca 2565961 taatcgcctt ctgcttcatt tatctttatg gtctcaatgc cttgagcagt ccagcccatt 2566021 tcatcgctca gagctacacc gagtgttttg gttcctaaat cgagtcctaa tattctcatt 2566081 ctttatttac gcctctttat gctgttctaa ataagacttt accaattcct cgattaattc 2566141 gtctctttca agtttgcgaa ttaaattgcg agcgtcacga tgcctaggaa tataagcggg 2566201 atcacctgac agcaagtatc cgacaatctg gttgattgga ttgtagccct tttcctgaag 2566261 cgcgtcatac actgtaatca gcacctcatt tacgttagtc tcagcagaat catcggagaa 2566321 attaaatttc atcgttttat caaacgagct caccgttttg cacctctttc ccaaattcgc 2566381 aggcaaagtt cagcctgggg tcctaatctt accatcattc tacactacat gggcgaatta 2566441 taaaacggat ttcacccaat cttctacaga agccaaagct tcttctaatt tttccggctg 2566501 tttaccgcct gcctgcgcca tgtccggacg gcctccgccg cctccgccgc aaacttccgc 2566561 agcttgttta accagcttgc cggcgtgaag tcctttctca atgaggtcct ttgtgactcc 2566621 ggcagagata ttaactttat cgttttgtac cgcaccaagc acgatcaccg cagagccaag 2566681 ctttgctttg agttcatcga ccatagtgcg gagatgattc atgtcttttg catttacttt 2566741 tgccgcaagc acgtttacgc cgtcaacttc ttttactttc gacaggattg ctcctgcttc 2566801 cacgttgcct agttttgcaa gaagagattc attttctctt tgtgcatcct tcagttcagc 2566861 ctgcagagcc gcgacccgtt tcggcacttc tttgatattt gttttcagct cgtcagcggt 2566921 ctgcttcaat acagaaatct ggctgttcat ttcgacgtaa gcgccttgtc ccgttacagc 2566981 ttcaatccgt cttgtgcctg ctccgattcc ggattcagaa acgattttaa acaagccgat 2567041 ttctgctgta tttctgacgt ggcagccgcc gcacagctct aagctgtaat ctccaacttg 2567101 aacgacacgg acaatatcgc catatttttc gccgaacagt gccatcgcac ccatttcttt 2567161 tgcttcagcg atcggtttca aatcaatgct gaccgggatg ctcgcccaga tcttttcgtt 2567221 tacgattctt tcaatttgtt cgagctcttc ttttgtcact tggccaaagt gcgagaagtc 2567281 aaaacgaagg cggttttccg ttacaagaga gcccgcctga ttgacatgag ttccaagaac 2567341 atcttttaga gcctgatgca ataaatgcgt tgccgtgtgg tttttaatga cgccgcttct 2567401 catatggtct tcaacttcag ccgtaacatg caggcctttt tgaacagtac cgctctccac 2567461 aacaccttca tgcacatgct ggccgttcgg cgctttttga acatctttaa ttcttacaac 2567521 tgcctgctcg cttcggagat agcctttgtc gccgatttgg ccgccgcttt ctgcatagaa 2567581 cggtgtttca tcaagaatga tttgaacgct ttctccttca tgagcctctt cgattaattg 2567641 gccgtcctga agaagcacaa tgatattggc atcagctttg gtttgagagt agccgacaaa 2567701 tgtgctttca actgtcacgt cgcgcagtgc gccgccctgc acctgcatgc tgccgacatc 2567761 ctggcgggcg tttcttgccc gttcacgctg ctggttcatt tcctcctcaa agccctcatg 2567821 gtcaaccgtc atgttctcgt cttctgcgta ttcttcagtc aattcaaccg ggaatccata 2567881 cgtatcatac agtttaaaca catcagcacc tgagataacg ctgctgccct tgtctttttc 2567941 ttttttgatc atttctgaca ggatcgcaag cccttcatta agggtctcat ggaagcgttc 2568001 ttcctcggtt ttaatgactt ttgcgatgaa atccgctttc tctttcactt caggatagaa 2568061 atcagccatg atttctgcga caaccggcac taaatcaaac atgaacggac gatggatgtt 2568121 gatcgttttg gcataacgca cggcacggcg taataagcgt cttaatacat agccgcggcc 2568181 ttcatttgac ggcagcgcac cgtcactgac agcaaaggca accgttctga tatggtcagc 2568241 aatcacttta aacgcagtgt ctttcacatt gtctttgcca tatgtttcac cagaaatcga 2568301 ttctgttgct ttaatgatcg gaacaaacaa atcggtgtca aagtttgtcg gaacattctg 2568361 gatgacagac accattcttt caagacccat gcctgtatca atatttttct ttggaagcgg 2568421 tgtgtacgtg ccgtcagggt tatggttgaa ctctgagaac acaaggttcc atacttccag 2568481 gtaacggtcg ttttccccgc ctgggtaaag ctccggatct tctggatcat taccgtatgc 2568541 ttcaccgcgg tcgtaaaaga tttccgtatt cggtccgctc ggcccttcac cgatatccca 2568601 gaagttccct tccagacgga taattctttc ttcaggaata ccgatttttt tcgcccaaaa 2568661 ctcatatgcc tcttcatctt caggatgaac cgtaacagag agaagctctt tgtcgaagcc 2568721 aatccacttg tcgctcgtta aaaactccca agcccatgta atggcttctt ctttgaaata 2568781 atcgccgatg gaaaagtttc cgagcatttc aaagaaagtg tgatggcgcg cagttttacc 2568841 tacattttct atatcgtttg ttctgatcgc tttttgagcg tttacgattc ttggattttc 2568901 cggcacgaca cggccgtcaa aatatttttt cagcgtcgca acaccgctgt tgatccaaag 2568961 cagtgaagga tcctcatgag gcactaatga cgcgcttggc tctaccgcat gtcctttttc 2569021 tttaaagaaa tccaaaaaca tttgacgcac ttccgcagaa gttaagtgtt tcattgtatt 2569081 tcctcctcta taaaaatcga aattctcttc agtgacagca aaaaagccct ccccctatgc 2569141 aaaccaacgt ttacacaggg acgagagctg tctcgcggta ccaccctgat tacgggcatt 2569201 catgcgcccg tcacctttaa ccctgtaacg caggataagc ggcagtgatt aactgcactc 2569261 aggattagct tcctccgatc ttctgataaa gctcctttca gcttatggag cttctctctt 2569321 taacagggct tcggcgtact cagatccgtc actcgagatt cgtatgtatt ctacgagaaa 2569381 ttatagacaa gcggcacgcc gatgtcaatg ctccgtcctc atccgcaaaa aatggatcat 2569441 cattactttt aaaacagccg tcgcaggaac agccagaatc atcccgacga tacccgcaag 2569501 ctcccctccg gcaaggagtg caagcatgat aacgaccgga tgcattttaa ggcttctgcc 2569561 gacaatgaac ggactgagga tatttccttc cataaactgc agaataaaca ccgtaatcac 2569621 cacaacaaga accgccttga ctgagatcgt catcgcaatt aacaacgcag gaacagctcc 2569681 gatgaaaggg ccaaaatacg ggatgacatt cgttacccca gagataaggc caagtatcag 2569741 cggatacgga agcccaaata cccagaacga aatgcctgca atcacgccaa gaatcaagca 2569801 gaccaaaagc tggccgcgga tataatcgcc aagcgaatca tccacatccc gcaaaaaggc 2569861 gctgccccgc tttctccacg acttcggagt caagtaccat actgtctttt tcattaactc 2569921 aatgtccttc accatataaa acacgagaaa agggattgtt gcagcaatta agaagtaatc 2569981 aagcacattg cggatcccgc tgatcgcacc ctcgatcgtt cccgcaaaaa acgcctccgt 2570041 ctggcggatc attttatcta tacggtgatg cataccatca ggccagtcat ccgtatggtt 2570101 atgcacatga agaagaagcc cgttatacgt ttcggcaaac atgggtatat tttctgacaa 2570161 atccgtcagc tgcacgatta aaacaggcac ccctttatac aacgcccagc caatcccgcc 2570221 aaaaaaaaga acataaatga ccaagatgct caaagtccta ggcaatcctt tgccatgcag 2570281 ccattctgtg accggaagca ataaataaga tataaaaata gaaatgatca agggaataaa 2570341 gatcgttttt atgacgagcc aaaagggtga ccataacata tcaagcataa aaaagacata 2570401 gactgttaac agaaccagca aacaaatagc cacccacaac aaaagctgca ccggtttttg 2570461 gagcatctgc tttcacctca cctatatctt ttgaggttta caaggaatta ttctttatgt 2570521 ttctttagtc agtcagaagt catggacatt ttttcacttt taattttcag aaaagtttga 2570581 tcatttactt tttggtcaaa ttttctgata ggaggattgc gatgatcaca tttcaaaatg 2570641 taaacaagca ttacggagat tttcacgtgt taaaacaaat taatcttcaa atcgaaaaag 2570701 gtgaagtcgt tgttatcatc ggcccatccg gttccggtaa aagcacattg ctcagatgca 2570761 tcaacagact tgagtcgatc aatgagggag tgcttacagt aaacggcacc gccattaacg 2570821 acagaaaaac tgatatcaat caagtgcggc aaaatatcgg gatggtgttt cagcactttc 2570881 atttatatcc gcataaaaca gtgctgcaga acatcatgct ggctccggta aaagtgctta 2570941 gacaatcacc tgaacaagca aaggaaacgg cgcggtacta tcttgaaaaa gtcggcatcc 2571001 cagacaaggc tgacgcctat ccttcccagc tttccggcgg gcagcagcag cgtgttgcca 2571061 tcgcaagagg actggcgatg aagccggagg tcatgctgtt tgacgagccg acatcagcac 2571121 ttgatcctga aatgatcggt gaggtgctag atgtcatgaa aacactcgcc aaagaaggca 2571181 tgacaatggt tgtcgtgaca cacgaaatgg ggtttgccaa agaagttgcc gaccggattg 2571241 tcttcattga cgaaggaaaa attttagaag aagcagtgcc ggctgaattt tacgcgaacc 2571301 cgaaggaaga acgggcccgc ttattcttaa gccgtatttt aaatcattaa aacagaaatg 2571361 ggggagcttg tatgaaaaag attttttctt tagcattgat ttctttattc gctgtcatct 2571421 tgcttgccgc ttgcggcagc aagggatcaa acggagaagc ctcaaaggag agcaaaaaag 2571481 atacgctagc cgccattaaa gacaatgaca aaattgtctt cggcgtaaaa acggacactc 2571541 gactgttcgg tcttaaaaat ccaagctcag gtgagattga gggttttgat attgatattg 2571601 ctaaacaaat cgctaaagac attttaggtg atgagaaaaa agctcaattt aaagaggtca 2571661 cctcaaaaac aaggattcct atgctgcaaa acggggatat cgacgccatt gtcgccacaa 2571721 tgacgatcac tgaagaacga aaaaaggaag ttgacttttc tgatgtctat ttcgaggccg 2571781 ggcaatcgct tctcgtgaaa aaaggcagca aaatcaagag tgtcgagaat cttggcaaag 2571841 gctcaaaagt tcttgcagta aaaggctcca cctcctctca aaacattcgt gaaaaggcgc 2571901 ctgaagcatc tgttttagaa tttgaaaact acgcagaagc ctttacagcc cttaaatcgg 2571961 ggcaaggcga tgccctcacc acagataatg caattttata tggaatggct gatgaaaata 2572021 aaaattatca attaacagga aagcctttta cagatgagcc ttacgggatc gccgtgaaaa 2572081 aagggcaatc tgctctcgcg aaagaaatca acgcttcact taaaaagatg aagtcggatg 2572141 gcagatacga tgaaatttat aaaaaatgga tcaaagaaga cccagctgaa taacaaccat 2572201 cccgggatga gcaggcgatg ctcatcccaa tttgataagg agtgaatagg cagatgaatg 2572261 tgtcaattct tttcgataac ttcagcatgt atatggacgg tttttaccat accttgctcg 2572321 caagtgttat cgcgctggcc ggcagttttg tcctcggcgt tgctgtagcg gttatgagaa 2572381 taacagtctt taagccgctg caatggctcg ggaccgcata tgtagaattc atccgcaaca 2572441 tccctcttct tttaattacc tttgttttct atttcggact tccaaacgca ggcctgaggc 2572501 ttgacggttt tcaagcggga acggttgctc tcaccattta tacctctgcg tttatcgctg 2572561 aagccatcag agcaggcatc cagtctgttt caaaagggca gatggaagcg gcacgctcgt 2572621 caggctttac ctacagccaa gccatgctcc atatcatttt gccgcaggca atcaaaatcg 2572681 tcattccgcc tttaggcaat caatttttaa acttagtcaa aaactcttcg attcttgggg 2572741 ttgtggccgg attggatctt atgtaccaag ccgatttagt ttcgtcgagc acactcgttg 2572801 tatttgatgt ttatattttt gtggcgcttt tttacttagt gctgacgatt ccgcttagca 2572861 tcggtgttaa ctatctggaa aaacggctgg aaaaaagcta ttgataagga gtgagttaca 2572921 ttggatttca tcggtgctta ttcacaggag catttagcgt ttttatggga tggctttctc 2572981 gtcaccttgt acgttgcttt catctccatc attctgagct ttttcttcgg tttaatcgca 2573041 ggcaccctgc gttatgcgaa agttcccgtt ctttctcaat tgattgcagt tctcgttgaa 2573101 acgatcagaa acctcccctt gctgttaatt attttcttta cgttttttgc ccttccggaa 2573161 attgggatta agcttgaaat tacagctgct gcaattacag cactaacgat ttttgaatcc 2573221 gctatgctat ctgaaattat ccgaagcgga ctgaaatcaa ttgacaaagg acaaattgaa 2573281 gcggcgcgct cctccgggct gagctataca cagaccctgt tctttatcgt tatgccgcaa 2573341 gcgcttcgcc gcatggttcc gcccatcgta agccagttta tttctttatt aaaagataca 2573401 tcgctcgctg ttgtgatcgc cctgcctgaa ctgattcaca acgcgcaaat tattaacggc 2573461 caaagcgctg acggcagtta ttttttcccg atctttttac ttgcggccct tatgtatttc 2573521 gcagtcaact acagcctttc actcgcagca agacgcctcg aggtccggca aacatagaaa 2573581 aggatactct ttggagagta tcctttttgc attaaaacat tttcgtaatt cttcttctca 2573641 tccgcttcat gcttcgatta ttcagcatgt cagattgagt cgccattcgg tacacgagag 2573701 ctccggctcc cattgccaaa agagaagtca tcgtccgatt catcctgcgc atctcctttc 2573761 atgattaaaa attgatgctg cgttcatcct cagaaaacaa atcatccaag ctgcttaacg 2573821 ttccgtcttc ttccacctga tgagttgcaa tcttcccttt cgccactgtc agttcaataa 2573881 aacagcccca gcaataatat tggttcacgc cgattttgcc gatatcctta cttttgcaat 2573941 tcgggcatat aagcatacct cacacctcta tccgttcaga acgatctcgt ctttccgcac 2574001 ctcgacaagc gaatccgctc tttggatctg gcgcttgctt cccgccaggt cagaaaagaa 2574061 accgtccgag agttcatatg ctacgattat gcccctgtcc aaacaaaagt atacatcttc 2574121 cagcatcccc aatatatccc cctcttgcga tttcacaagc ttcatcttca tctgctcgta 2574181 tgtgaagcat gatttcggaa gaggcaaaag ctgttctgaa ctgaccgaag ccaatatgcg 2574241 gtcatcaaaa atggaagaga tatcacacgc ccgtaatagc gcatgatgat gatgcaaaaa 2574301 gcgtttttgt gcaagaataa acccaagaca atctcctttc agagaaaaac aaatatcgga 2574361 aattgtcccg agataactag aagttcgttc tgagtatact gggaatcctt ctacttcatg 2574421 gcatgttctc aaagtgtgat caaccacctt ttgttgaaca ggcttaggtt ttgctttgcg 2574481 ccttagactc atacgatgaa atcaattcca ctgcaaatga aaaaaaactc ccgcttgcac 2574541 gggagcattt tattgctgtt cttctttcat aaaatcgaat ggtgtaatgc cttccatgcc 2574601 aatgttggcg tcgtgtacgc tgaacgggag ctctttttgc aaagcttcaa gctcggcatc 2574661 catttcctca acctgtacgg acagcctgtt tttcaaggag gtctgtctga cagttgcatc 2574721 attatttttc acgccccact ccagcgcctc ctcttccccg cataaaatga gaaatttctt 2574781 cgctcttgta atcgcggtat aaagaaggtt tcttctgagc attctataat agcctttcac 2574841 aacaggcaaa accacaatcg gaaattcact tccctgcgat ttatgaatag aacagcaata 2574901 cgcatgggta aattgattaa aatctttttt cgtaaatgtc atttcattgc cgtcaaaaga 2574961 aacgacggcc atgtcttctt tttctgtatt ttcctttgca taaaatatcg acgtgatttc 2575021 gccaatatct ccgttgaaca cattgttttc cggctgattg acaagctgca aaattttatc 2575081 tccggttctg tagacaacat ccccgaactt caattctctc cgtttttctt taggaggatt 2575141 taaaatgtcc tgcagcatca cattcaattc attaatgccg gcttttcctc tgtacatcgg 2575201 agcgaggacc tgaatgtcct ttgctgtata gccttttttc aatgcattgg cgacaacctt 2575261 ctcaactact tctttgattt gcgacccgcc gcagcgaata aaggaacggt cctttgtcgg 2575321 ggcagtcaaa ttgttcggca gcaatccatt tttcatctgg tgggcaagct cgacgattga 2575381 tgacccttct gcctggcgat agatgtctgt cagtctcaca gtcggaatca cctgggatgc 2575441 cagcaggtct ctgagcactt gtcccggacc gacggaaggc agctggtctt cgtctccgac 2575501 aatgatgatt tgtatatgat cagggatcgc cttgaacaaa tgattcgcca gccatatatc 2575561 aagcatactg gcttcatcga taattaacag cttcccttcg atcggctgat cctctgtatg 2575621 agtaaagcct tcagcgccgt tccagccaag cagcctgtgt atcgtaactg cagggagtcc 2575681 cgttgattca ctcatccgtt ttgctgctct ccctgtcgga gcggccaaaa caatcggaaa 2575741 agcttcatcc tttttataag ctgacgggtc tagtgacaca ccgtgaagct ctccgtagag 2575801 ctcgacaatc cctctgatta ccgtcgtttt tcctgttccc gggccgcctg ttaaaagaag 2575861 catcggcgag gaaagggctt tttgaatcgc ttccttctgg ctgggggcat actgaacgtc 2575921 catccgttct tccagttctc ccaacgcgag caaaaactct gattcgggaa actggttctc 2575981 atattcggtt tggctagcga tatgtttcac acgctttgca acgttttgtt ctgcgtaaaa 2576041 cagcgaagga aaataacagc ggccatcttc tatgacaatg tctttatttt ctccaagggc 2576101 aataattgcg ttagcggcat ccatttctgt aatgcgctgc ccttcccttg ctgactggtt 2576161 taacagtgat tgagtgtcga tgatcagctg ttccgtttct atgtacgtgt gcccctctga 2576221 cagacaagtc gtttcaagcg tgtacaaaat agcagctttt acccgctcag gatgattacc 2576281 cgaaagaccc attctgctgc ccagctcatc cgcttttcca aacccgatgc cttctacatc 2576341 cttcacaagc tgataaggat tttcctgaat cttttcaagc gtctcggatt cataggcttg 2576401 atagattttc atagacagct gcgggccaaa gccaaactga ttcaaggaaa tcatgatttg 2576461 ctccagtccc tgatgccgct gcaatgcgcc agccagcgtg tctgctttct tttttgagag 2576521 tctgggaaca tcataaagca ctgaagcatc agccaatatt ttattaatgg cgctgtcgcc 2576581 cagctttttc acaatttctt cagctgtttt tttgccgatc ccctcgaata aatcactcga 2576641 taaatattga atgatgcctt ccttagtcgt tggaatctcc tttttgaaat gctccgcctg 2576701 aaattggagc ccgaattttg gatgggttac gatctttccg taaaacgtgt aggtctcttc 2576761 ttcttgaagc gcagggaagt agcccgtcac ggatacggct ttatcttcaa tggcttcgga 2576821 ggtctctgtg actttcactt tcagaaccgt atataaattg gtgtcattat gatagatgac 2576881 tgtgttgact gtccctttta aatagggctc ttcctccagt ttaagctgat ccggatgctg 2576941 ctgcacgagc tgtccctcct cctgtgcctg ttatgatgga tcaatcagtt ttttagcatg 2577001 aagcgcaagc atatgatctg gctggatatc gattgccttg tccagcattt ccagcgcttt 2577061 ttctcggttt tctttataag cataagtgac accggcatta taaaatgcat ctgcatgccc 2577121 cgggtcttgc tctgtcacag ctgcgaattg gctgagcgct tcgtccagca tgccctcgtt 2577181 ggctaagcac atcccgaatt gaaaacgcgc ttccgtatcg ttttcattca gttcgactgc 2577241 tctttgtaaa tatggcagtg caagcttagg ctgttcgagc ttgacaagta ccgttccgag 2577301 catgtaaaac aggtcgccgt tttccatccc cgcacgtagc gctttttcaa acatgtcttt 2577361 cgcttctttg tacatttctt ttacaacata gacatttcct gctccataat aagcagtggc 2577421 tgcgctactg tctaattcaa gcgctttatc ataaaacgca agcgcacgtt ccagctcgtt 2577481 tacggatgaa agaaggttgg caaaattgat atacggaatc gcgtcttctt tattttcttc 2577541 aatcgctttt gtaaatgcct ctgccgcttt ctcgtaatcg ccttcctgca tcgcctctat 2577601 accgagttga ttataatcca ccgatcatct tcctttcatt aaaaaacccc aactcagtgt 2577661 tgaggttttt catcttttat acgtaccaca attttgttcc gtctttgtac acatcatcaa 2577721 ttgtcccgcc gccaaggcat tcttcgccgt catagaagac aacggcttgt cccggcgtta 2577781 cagcgcggac ttgttcatca aagatgactt ccgcttcacc ttcgccagtc atgcgcactg 2577841 ttactttatg atcctcttgg cggtaacgga atttagccgt gcaggaaatc tcttcgccct 2577901 tcatgatatc cgaacgtacc cagctgatat ttgttgctgt gattttgtcg gaatataaaa 2577961 gcgggttatg gaacccttga tctacgtaga ggatgttctt ttcaagatct ttgcctaccg 2578021 caaaccacgg ctcgccgctt ccgccgatgc caaggccgtg acgctgtccg atcgtatagt 2578081 acatcaaccc gtcgtggcgg ccttttactt cgccgtccat cgtcatcata tcgcccggct 2578141 gtgcagggag atattggctg agaaacgttt tgaagttgcg ttcgccgata aagcagatgc 2578201 ctgtactgtc ttttttcgtc gctgttgcaa gttctgcttc tttggcaatt tcacgcacac 2578261 ggcttttttg aagttcgccg atcgggaaca tgactttgct cagcgtatct tctgtcagct 2578321 gattcaggaa gtacgtttga tccttgtttt catcaatgcc gcgcagcatt ctgacttttc 2578381 cgccgcttct gtctactctt gcatagtggc cagtcgctaa atagtcggcg ccaagtgaca 2578441 atgcatgctc caaaaaggcc ttgaatttaa tttctttgtt gcacaataca tccgggtttg 2578501 gtgttctgcc tgctttatat tcatcaagga agtattgaaa taccttctca taatattgct 2578561 tttcaaagtt tacggcataa tacggaattc cgatttggtt gcagacgcgg atcacatctt 2578621 cataatcctc tgtcgccgtg caaaaaccgt tttcgtccgt atcatcccag tttttcataa 2578681 agattccgat tacatcatag ccctgttctt ttaacagcag ggccgccaca gatgagtcta 2578741 ctccgccgga catgccgacg acgactcttg tatcctccgg ccgtttttcc atttcattca 2578801 ctccaattac tacgccgcct tattatgtca gccgtttgac aacgtcggcc acatgtttgg 2578861 cagcagtttt cacttgctca gccgtattgc cgaggccgaa gctgattcga atagaggacg 2578921 tcagccggtc actctcttcg ccgaacatag cagtcagaac atgtgacggc aggactgaac 2578981 cggccgtgca cgctgaaccg ctggagacag cgacaccagc catatcaaga ttaaccagca 2579041 gcgcttccac tgacacaccg gggaaataaa gattcagaac atgcggcaga ctatgctctt 2579101 tgtccccgtt gacctcgaat gccacacctg catctctaag cgtgtcggca aagattgctt 2579161 taaacgattg atacttctcg tttttttcgt cacgttcttc acttgacagc ttgatcgctt 2579221 ctttcagccc gacaatgcct ggaacatttt ccgttccggc acggcgtttt ctttcttgct 2579281 ctcctccgaa taaaaggggt gaaagcttca catctttact agcatataaa aagcctgtcc 2579341 cttttggccc gttgagcttg tgcccggaaa cagacagaag gtcaatatgg ctgtttttca 2579401 catcaattgg cagcaacccg aatgcctgaa cagcatcggt atgaaaataa gctttgtgtt 2579461 cctttaacag ctcaccgatt tcttcgatcg gctgcactgt tccgacttca ttatttccat 2579521 acatcactgt cacaaggatt gtatcatcac gcagtgcttc tttcacctgt tttgcactga 2579581 ctcttccatt ttggtcaacg tccagatacg ttatgtcaaa tccgtctccc tcaagttttt 2579641 cacatgtgtg aagcacggcg tgatgctcaa tttttgttgt gatgatatgt ctgccaagat 2579701 cttttcttgc aagtgcggtt cccatgatcg ccaagttatc agcttccgtt cccccgcttg 2579761 taaaaatgat ctcctgctct gccgctccga tttctgctgc gatctgcgct cttgcttcat 2579821 ccacccattt tcgagattct ctgccaaatg aatgaatact ggagggatta ccgaaactgc 2579881 cggagaagtg cggtatcatt tgttccagca cgcgctcatc catcggagac gttgcggcat 2579941 gatctaaata aatccgttcc attatgttta cacctctgat ctaaatatag aacatataag 2580001 cttcttgctc tccgtctgta tagctggcaa gatcctctaa tgttgtactg tctaaaacct 2580061 cttttacagc atcccggatg cgaatccaga gctcacgctt ggcaggctcc tcatcttcca 2580121 gcacttcaac agggctgatc ggcccctcaa gcacacggat aatatctccc gcagtaatgg 2580181 catccggctc actgcctaat acatatccgc catatgcgcc tctgatgctt ttcactaaac 2580241 cggcatttct gagcggcgat accagctgct ccaaataatg ctcggacaaa ttattcgtct 2580301 gtgcgatgct ttttaatgaa gtcgggcctt caccgtgctt ttttgcaagc tcgatcataa 2580361 tggtgagccc gtatcttccc ttagttgata ttttcaacat gaacacctct gttatttcat 2580421 gattttccac atttataatg gtaatttcta tatgtttcgt ccgtttatta tcttatagac 2580481 caactgttat tataacatac cttcagcgaa ttttcattga ggcagaagga aaggggcctt 2580541 tacccttttc taatgtacgg ttttccgtta ccctgtaatt aagtaaggag agatgataga 2580601 tgaagccatt ggcatatcgg atgcgtccga caaaaataga ggatattatc ggccagcagc 2580661 atctggtggc tgaagataaa attattggca gaatggtcca ggcaaaacat ttgtcatcca 2580721 tgattttgta cgggccgccc ggaattggaa aaacatcaat cgcaacagca atcgccggtt 2580781 caacaagtat tgcttttcga aagctgaatg ctgtcattaa caataaaaaa gatatggaaa 2580841 tcgtagctca ggaagccaag atgtccggcc aagtgatttt gattctggat gaagtccaca 2580901 ggctggataa aggaaaacag gattttctat taccctattt agaaaacgga atgatcattt 2580961 tgatcggagc aacgacggct aacccgtatc atgccattaa tccggcgatc agaagccgga 2581021 cccagatttt tgagcttgaa ccgttaacac ctgaactgat taaacaggca ctggaacgtg 2581081 cgctccatga tgagcatcgg ggccttggca cctattctgt atccattgat gatcaggcga 2581141 tggagcattt tgcccacgga tgcggaggag atgtccgctc cgctttaaat gcgcttgagc 2581201 ttgccgtgtt gtcaacgaag gagtcagcag acggtgaaat tcacattaca ttagaaaccg 2581261 cggaagaatg cttgcagaaa aaaagctttt ctcacgataa agatggtgac gcgcattatg 2581321 atgtactgtc cgcttttcaa aaatcaatcc gcggctctga tgccaacgct gctcttcact 2581381 atttggctag attaattgaa gccggtgatc tggagagcat cgcaagacga ttgcttgtta 2581441 tcgcctatga ggatatcggt ttagcaagcc cgcaagccgg ccctagagtg ctgaacgcta 2581501 ttcagaccgc tgagcgagtc gggtttcctg aagcgcgaat cccgctggcc aacgcagtta 2581561 ttgagctttg cctctcaccg aaatcaaact ctgccattct ggcaatcgat gaggccctgg 2581621 cagatatcag agccggaaaa attggggatg tcccgaagca tttaaaagac gcgcattata 2581681 aaggagctca ggaattagga agaggaatcg actataaata cccgcacaat tacgacaacg 2581741 gttgggtcga acaacaatac ctccctgatc ctctgaaaaa taagcaatac tataagccga 2581801 aacagactgg aaagttcgaa tctgccttaa agcaggtgta cgataaatta atgaaaagaa 2581861 aataaaacaa aaaaacagcc ttgatcatca aggctgtttt tatgcattat ttatccttca 2581921 cacgtttgat ttcaatgtct ttcaaaagat ccatgacaac atgtccgccc ataatcaaac 2581981 ctgcaactga cggcacaaaa gcattagagg aaggcggcat ttttgcttta cgtattttcg 2582041 cttcgtcatt ccccacttct tttctgacat cttcccgaat aacaatcggg ctttcatcag 2582101 agaaaatcac ttgaacgcct tttttgatac cctccttgcg taatttcgta cgaacgacct 2582161 tcgcaattgg atcagtgtgc gtttttgaga tatcagcgat ttggaagcgt gtcggatccg 2582221 ttttatttgc agcacccatg ctggagatga gcggaatatc ccgttttaga cattctttca 2582281 ttaaatgaat tttataacaa atggtgtctg acgcatcaat gacatagtca agaccatagt 2582341 caaaaaactg ctcatacgtt tcctccgtat agaacatttt taacgcgatc acttcacact 2582401 ccgggttaat gtctgcgatc cgcgccttca ttaaatcaac tttcggctgt ccgacagttg 2582461 aaagcagcgc gtgaagctga cgatttacat ttgtaatgtc gacatcatct ttgtcgacaa 2582521 gcagaatgcg gccgacgcct gaccgcgcga gagcttccgc cgcgaacgac ccgactcccc 2582581 cgactccaag cacagcaact gtgctgtttt tcagcgtttc aaggccttct tttccgatag 2582641 ctaattcatt gcgtgaaaac tggtgtaaca agaacctcac tccacattcg tattctggtt 2582701 tcatctataa aatggctgat ccatgagcag ccgttttttc tgcgcacaaa aaataaagtc 2582761 ccaatagtgc cgttgcagct ttcctttgtt ttgaacccgc tctcagcagg tgggtgccct 2582821 cttttaaatc ttgtaagtcc tctttaccga atgaaaagag gcatgtacgc catttaaaaa 2582881 tgcgggctcc caaatcaaaa aaatgttcgg tcaaaactag gtgtacaact aacacatcag 2582941 gactttattt aacttgtcaa aatcatatca cagacgattt tgattttcaa gaatcgaact 2583001 gcaaattcag ttcttaactt ttttcttgat agaaagatga agctcgtcaa gctgggcgtc 2583061 gcttacttcg cctggcgctt ctgtcatcag gcagcttgca cttgccgttt tcgggaatgc 2583121 aatcgtatct ctcaggttcg tacgtccagc gagaagcata acgagacggt ctaagccgag 2583181 tgcgattccg ccgtgcggag gagcgccgta ttcaaatgct tccagcagga atccgaactg 2583241 ttcagccgct tcttctggtg agaagccgag aagcgcaaac attttttcct gaatatcctt 2583301 ttcgaaaata cggattgaac cgccgccaag ctcatagccg tttaagacga ggtcataagc 2583361 ttgcgctttc atgtcttcag gcgctgtttc aatcagctca aggtcttctc ggacaggcat 2583421 tgtgaacgga tggtgcgctg cgtaaaaacg gccttcttcc ggatcatgct ctaatagcgg 2583481 ccagtcgatg acccataaga aattgaacaa tttttcgtca atcagtccgc gttctttccc 2583541 aagctttaag cgcagggcgc cgagtgatgc ggccacaact tcgaattgat ccgctccgaa 2583601 cagcagcaaa tcaccttcag cagcatcaag tgcttcaatc agcttagact gcttttcttc 2583661 atcaaagaat ttagcgatcg ggcctttcac tccgtctgcc tcaaccttca cccaggcaag 2583721 cccttttgcc ccgtagtttg cagcaaaagc gccaagagcg tcgatgtctt ttctggagta 2583781 atcgccggca ccgcctttta cattgatggc tttgaccacg ccgccgtttg ctacagctga 2583841 tgagaacact ttaaattccg tatcctttac aatgtcagac acatccgtca aaagcatgtc 2583901 aaaacgcgta tccggtttat cagacccgta cttgttcatt gcttcgtcat acgtcattcg 2583961 aggaagagga agctgaagtt cctcaccttt tgtttcacgc ataacctttg ccatcatctc 2584021 ctcagccaat gacataatgt cttcctggct cataaaggac atttcaatat caatttgcgt 2584081 aaactcaggc tgacggtccg cacgcaagtc ttcatcgcgg aaacagcggg caatttgata 2584141 atatcgttca atgcctgata ccatcagaag ctgtttaaat agctgcggag actgcggcag 2584201 cgcgtagaac tcaccttcgt gcacacggct cggcaccaag tagtcacgtg cgccttcagg 2584261 cgtgcttcct gttaaaatcg gcgtttcaat atcaagaaac ccattttcat ctaaaaagct 2584321 gcgaacagct ttcgtcacgt tatggcgcag ctgcatcgtc tggaacatag ccggtctgcg 2584381 caaatctaag taacggtgtt ttaaacgaac gtcctctgac acttcttcag cttgatcaga 2584441 aatcgcaaat ggaggtgtct ttgcagcatt taatacgttc actccatcag catgtatttc 2584501 gatcgcgcct gttttcaaat tcggattaac tgttccctct tcacgcgcca ccacttttcc 2584561 ttgaatatca agcacgtatt catttctgat gccttccgca atagcaagcg cttcttttga 2584621 cacatcaggg ttaaaaacga cttgaacaat gcccgtacgg tcacgcaagt caataaaaat 2584681 caatccgccg aggtctcgtc ttttttggac ccagcctttc agcgttacag attcgccaat 2584741 tgctttttca gttatatcac cgcaataata tgttcttcca aacaatgcgt ttcactcctt 2584801 atcccttttg gtttgccttc atcacatgta taaattcatc aagtgccact tcaatctgtt 2584861 cgcccgtctg tgcatccttt acattgattt tgttttgggc aagctcatct tcacccaaaa 2584921 tcgcaataaa tctggccttt aagcgatcag ctgttttaaa ctggcctttc attttcttat 2584981 tttcataatc gatttcactg gaaatgcctg cttctctcag tttgtacacc aatgaaacag 2585041 aataatcctt tgctttttcg ccgagtgtga cgatatagca gtcgattccc ttatcaacag 2585101 gcagctctct tttttcagca tcaattgcgg caagcaagcg ttcgatgctc atcgcaaatc 2585161 cgatgcccgg tgcttcaggt ccgccgatct gttcgacaag cccgtcgtag cgtccgccgc 2585221 cggcaagtgt cgtaatcgcg ccaaagccct ccgcattgct cataatttca aatgcggtgt 2585281 ggttgtaata atccagccct ctcacaaggt tcggatcgat ttcatacgaa atgccaagat 2585341 catttaagta ttgtttcact ttttcaaaat aagcggctga ttcttcattt aaatatgtca 2585401 aaatcgaagg tgccgatttc atcagctcat gatcacggtc ttttttgcag tccaaaattc 2585461 taagcgggtt cgtgtgcagc cgggactggc agtctgaaca aaattcttcg atgcgaggct 2585521 cgaagtgttt cacgagcgct tctctgtagc ttttgcggct atcttgatcg ccgagactgt 2585581 ttatgacaag cttaacgttt tctaaacctg ctttttcata aatactcatc gcaagcgcca 2585641 ttacttcagc gtcgattgca gggtctttcg aaccaatcgc ttcaattcca aactgataaa 2585701 actggcggta acggcccgtc tgaggacgtt cataacggaa catcggcccg acataataaa 2585761 gctttgtcgg ctgtacagga tttgcgaaca gcttgttttc attaaaagcg cgaaccgcag 2585821 cagctgttcc ctccggacga agcgtcaggc ttctgccttt gcggtcctcg aaggtataca 2585881 tttctttttg tacgatatcc gttgattctc cgacgcctct ggcaaacagt tctgtatgct 2585941 caaaaatcgg tgtgcggatt tctttatatt gataagtgcg gcaagtgtct ctcataattt 2586001 gttcaacaaa ctgccagcga tctgattctc caggcagaat atcctgtgtt cctctcggaa 2586061 tgttatatcc cataggtaga cctccttatg tattccttat aaaatatcca atgatcgtta 2586121 atgatgaaaa tgaaaaaaac tcccgcccct actatacatg atagtaggga cgagagttat 2586181 acccgtggtg ccaccctagt tggaatacgt tcatattccc gctcgatcct ttaacgcagg 2586241 ttcacgttca ctgcctaatg gcgttattca cgcgttcagc aggaaacctc cggagtgttg 2586301 tttcgagaaa gacgcaatgg gatccgcttt cagcctgggg cgggttcctc tctaatcatg 2586361 caatctgacc tactcttctc cattattggt tcaaatcttt catcatttgc tatgtactca 2586421 atttctatta taataatggg attggggttc tctgtcaagc tttattccgg ttgtttttcc 2586481 tcagcgctgc ttctttggac ataagaccaa attcagatgc tgtttccgta agataaccag 2586541 tcgtatcggg atctgcgtga tcgctgtaat gcagattcgc ttcaccgtcg tgaaatgcac 2586601 gtcccatttt tggatgatat ttcatgattt gcacaccttt ttgattgtat ttacgcttag 2586661 tataaacaaa tcattttatt tttatttaaa aatcagaaag gactttacga tattaaacaa 2586721 gaatgctttt ttaatgatca tcagaaagga ggacacaatg aacaagaaat actttgtcct 2586781 tattgtatgt attattttca cctcagcgct attcccgacc ttttcatccg ttacagctgc 2586841 tcaaggagaa gcggtcatcg caacagatga aatgaacgtc agaagcggcc cagggcttag 2586901 ctacggcatt acagcggaag taaaaaaggg agaacgctat ccaattttaa aggaagatgg 2586961 agactgggtg cagatacagc ttggttctgg agaaaagggc tgggtagtct cctggcttat 2587021 tacaaaggaa gaccaggcca gcacaagctc ctcaggaagc agtgacactg tgacatcaac 2587081 agaccccgat ctgcggatga gaagcggccc gggcacttcc tacgaagtca tcggcaaatt 2587141 cccgcaaggc agccaagcat ctgtcattga taaagattcg ggctggatca agatatccta 2587201 tcacagtgcc accggatggg tatcatctga atatgtcaca tcaggaggca gcagttcagc 2587261 gtctgatgag agtgaccaaa ccgaggattc cggtgcgtca acgacgggca cagtcggtgt 2587321 ttcttcgcta aatgtaagag cctccgcctc acatgacgcg gcaattataa caaaacttga 2587381 tcgcggaacg aaactgacgg ttctcaacga gaaaaatggc tgggctcaca ttgaggtgaa 2587441 cgggctaaaa ggctgggttg caagccatta ccttttgact agttctgttc cagctgatga 2587501 ttcagcaaat gccggcagtt catcctccgc taaaaaagcc tatatcatgt acggaggaac 2587561 gaatctaaga agtgatgcgt caacatcagc ttcgatcgtt gagcgcgctg ccaaaggaga 2587621 ttcatacacc attaccggtt caaagggaag ctggtatgaa ataaagcttg ataacgggca 2587681 gactgcttat gtagccaatt gggtggtcca aacgtctaaa agcgcagaag aagcaggtga 2587741 accgccagtc tctgattccc cgtctggaaa cggctctcta aacaataaaa cgattattgt 2587801 tgacccggga catggaggaa aagacagcgg aacgatcggg tattcgggga aattcgagaa 2587861 aaacctgacg atcaaaacgg caaaactgct cgccagcaaa cttagatcgg ctggagcgga 2587921 tgtatatgtg acacgccagg atgatacctt tgtcagcctg cagtcacggg tctctacctc 2587981 tcactaccgt aacgctgacg cctttatcag cattcattat gacagctatg cggatacctc 2588041 tacaagaggc agtacagcat attactacag tcctgccaaa gatcaggaac tcgcatcaga 2588101 tgtccactca gaagtggtga agcgttcttc cattccagac cgcggcgtat tattcggaga 2588161 ttattatgtg ctccgggaaa acagacagcc cgctatgctg tacgagctgg gatatgtaag 2588221 ccatccgcag gaagaagcca ttgtacatag caattcatac caagaaaaag taacagatgg 2588281 gatcgaaagc ggattagaga aatacttcca ataaaaaaag ctgccttttg gcagcttttt 2588341 ttattttgaa tccataatga gcgtgaccgg tccggagttt gtaagctgaa catccatcat 2588401 tgctccaaac gttccggtct ccactttgat tcctttttca cgaagcaggt cattccattt 2588461 ttcataaaga cctaaagctt tatcaggttt ggccgcgttc atgtagttcg gccggcgccc 2588521 ttttttcgta tctccataaa gcgtaaactg tgagacggat aaaatctctc ctcctatatc 2588581 tacaagagac agattcattt tcccttcact gtcatcgaaa atacggagat tgacaacttt 2588641 atcggctaaa taagctgcat catcttctgt atcatcgtga gtgatgccga ccagcaccat 2588701 aaggccttgt ccaatttggc cgacgacctc ttcgtccact gtaacgcttg cttctgttac 2588761 tcgctgaaca actaatctct tttctaaccc ctttagttca tgacgcggcg cacagaatag 2588821 atatctctaa tctgtttaat acgctcgacg actttatgca agtgattgat attctggata 2588881 aaaatcgcca tatggatggt tgccacttta ttgcgatccg atttgccaga gacagatgaa 2588941 atattggttt tcgtttcatt cactgcctgg agtacctcgt tcagcaatcc gcggcggtca 2589001 tacccaagaa tctctatctc aacattgtat tccttgcgct tttgaacttg tgactcatgt 2589061 tcccactcta ccgggatcag ccgctcttgg gcttcattcg ttttgacatt cggacagtct 2589121 tcgcgatgga ccgaaacccc tctgcctttt gtgataaagc cgacaatatc atcacctggc 2589181 acaggattgc agcattttga taaacggaca aggaggttgt caatgccctt gacacgaacg 2589241 ccagcttccc gttttcttcc ttgcgggtat ggcttaggtt ccccagtgac ttcctgaacg 2589301 atcttttcct gttcttcctg gtcgcgctgc tttctctctt tttctgttag gcggttcgcc 2589361 acctgcagag ctgtgatgcc gttgtaaccg accgccgcgt acatatcctc ttcatttgag 2589421 aaattaaatt tgtcagcaac cttttgaata ttctccggcg ttaaaacatc cttcaattca 2589481 aaatccaagt ttttaatttc tttttcgacc agctcacggc ctttttcgac attttcttca 2589541 cgccgctgtt tcttaaagaa ttgacggatt ttatgcttcg cttgggatgt ttgggcaagc 2589601 ttcacccaat cctggctcgg accgtaggaa tgcttagagg tgagaatttc aacgatatca 2589661 cctgtccgaa gcttatggtc aagcgtaacc atttttccgt ttactttggc accgattgtt 2589721 ttattgccga tttcagagtg aatccggtaa gaaaagtcaa tcggaacaga accggacgga 2589781 agctcgatta catctccttt tggcgtaaag acatacacca tgtcagagaa caaatcaatt 2589841 ttgagcgatt ccataaattc ttctgcatct gtcgattcat tttgaaattc taaaatttca 2589901 cggaaccaag aaagcttttt ctcaaaggtt gcaccttcat tggctgcttt cccttcttta 2589961 taagcccagt gagccgcaac cccgtattcc gctatttcat gcatttcaaa ggtgcggatc 2590021 tgcacttcaa gcggatcgcc tttaggccca ataaccgttg tatgaagcga ttgatacata 2590081 ttcggcttcg gcattgcgat ataatctttg aatctgcctg gcatcggttt ccagcatgtg 2590141 tgaatgatgc caagcaccgc gtagcagtcc tttatgctat tcacaagaat acggacagcc 2590201 aacaaatcgt aaatttcatt gaattgctta ttttgcagca ccatttttcg ataaatgctg 2590261 taaatatgtt tcgggcgtcc cgagaagtca gccttgatat ttacttcttc gacacgtttc 2590321 ttcacttcat tgacaacctc atcgacataa agctctcgtt ctgcacgttt cttcttcatg 2590381 aggttgacaa ttctgtaata ttgctgaggg ttcaaataac ggagcgccgt atcttccaat 2590441 tcccacttaa tttttgaaat cccgagacga tgcgccaaag gagcaaaaat ttccagcgtt 2590501 tcattggaga ttctccgctg tttttcctga ggcagatgtt tcagtgtccg catattgtga 2590561 agacgatccg ccagcttgat caatatgacc ctgatatctt gagccatagc gacaaacatt 2590621 ttgcgatgat tttccgcctg ctgttcctct tgagatttat atttaatttt gccgagtttc 2590681 gttacgccgt ctacaagcat tgccacttct tcggaaaatg cttctttcag gtcatcgagc 2590741 gtcacatctg tatcttccac gacatcgtgc aaaaatccgc ccgcgattgt ggaagggtcc 2590801 atttcaagat caacgagtat ccccgcaacc tgaatcggat gaataatata tggctcgccc 2590861 gatttgcggt attgctcgcg atgagcatct tcagcgtaca gatatgcttt ttcgacaaat 2590921 gcgatatgct catcagatag atagctgcgt gctttatcta taacttgctc ggcagtcaat 2590981 acttgttcgt tcgccatgga atcacctttt ttaaaatgta aactgtattg tagtttatta 2591041 tcaagaaaaa aacgaaagat gtaaagagca gaagttcaaa tagccaaata ttatataaaa 2591101 taaatgcaaa acaataggaa aaaagcaccc tgacatggag tgctttttcg ttatgcggtt 2591161 atccttagta tttcatcaat gttaagatgt cgtaatcttc gagcttattt ctgccgtcaa 2591221 ggtaagaaag ctcgattaag aaagcgatac cagcaacaac gccgccaagt tcttcaacaa 2591281 gtttgattgt cgcttcaatt gtgccgcctg tcgcaagcag gtcatctgta ataagcacac 2591341 gctgaccagg cttaatcgca tctttgtgga tcgttaatac gtcttttccg tattccaagc 2591401 cataatccac tttgattact tcacgaggca acttgccttc tttgcggacc ggcgcaaaac 2591461 ctacgccaag cgcgtaagca acgggacagc cgataataaa gccgcgcgct tcagggccaa 2591521 cgaccaaatc aatttgcttt tctttcgcat attcaacaat ttgatctgtg gcatagcggt 2591581 atacatcgcc tttatccatc agtgtcgtaa tatctttaaa ttgcacgccc tctttcgggt 2591641 aatccggtac aattgttacg tattgtttta aatccatctg ttttatgtcc tcctcgtact 2591701 ttcataagcc tctgaatctt gtttcatcag cttattcagc cattccttca gctcttcagc 2591761 agaagaataa ttcagctttt gatccagttc catcagctgc tgtttcgcct gatatgtttg 2591821 tgagtctgtt aagtcgcgtt tctttgctcc gctcacaaca gacagcacac cattctctat 2591881 tttaacaaaa ccgagatcaa aaaacacctt tgtcatgaaa ttgattgttt caacggacca 2591941 gcctttatgt tttgcaagct ctgaaccgtg ttttttcacg tcaaaagcgc ctcttttcag 2592001 caagaacgca taataccatt taaagtggtc tcttgcggga aaagttgata aaaagtggtc 2592061 ctcatgattg agaaaaataa aatatatccg ctcgggcgcc tttccttcca gcaaacgtgc 2592121 gagcatgtcc agcgaaggcg gcggatccag taatacaata tatgcaccat cgaggtcaaa 2592181 cgcctttgct tgatctttag aactgatgac gtgcacttct cggcgaaggt cttcagtttg 2592241 aagtaatgtt gttgagtctt ctttgaaaga gacaatggcc cgtttagcag atggaagggc 2592301 ggaaactgtg tcttcccacg tccgttttcc ccttaaatca aacagctgcc attcagaaac 2592361 agcggcatcc tttatcataa gctgcggctt ttttcgattg ttccattcgt tgattgacat 2592421 ctcaccgaca atggaaattc ttgaacccgg tacgatgcct tcttgaagct cgcctttatt 2592481 aaaaccgacg caatcaagct gggacgactc gtttctgatc gtcattttga catgagtttt 2592541 atttgcccct atcttgcgga catcttccag tactgcattt tctacgagaa cgtgcggttt 2592601 cgggttcagc atgccaaaag gagacagcat gttcatttct gcgatgcttt caactgtaat 2592661 gtcttcgacg ccgcagacaa ggtcgacttc ctgtacggga ataaaatcct cttccgtaag 2592721 cgtattgtcc gctatttcat tcagcctgct tcgcaaatcc ggcacatctt cggctttcag 2592781 cgtcatcccc gcagccattg gatggccgcc gaaatgagga agaatatctc tgcattcaga 2592841 aaggctctca aataaattaa atcctctgat gcttcgggcc gaacctttag cgattccctt 2592901 ttcttcatca ataccaagaa caatggccgg tcggtagaaa cggtccacaa gctttgaagc 2592961 cacaatcccg acgactcccg ggttccatcc ggctttggcc acgacaattg cagtttgatc 2593021 gagcccttgc tgttcaacca tttcaatcgc ttcatccgtc attttgctga ccattttttg 2593081 gcgctctttg ttcagctggt caatttctgc ggcaagctct tccgcttcaa acgaatcctc 2593141 tgacataagc aaatgaacag cgggatccgc ctgttcgatt cttccgacgg cattcagcct 2593201 tggtgcgagc tgaaatccga ctgtttcttc gttcgcttct ccgatgtctc cgcctgacag 2593261 cttaatcagc tcttttaagc cgagccgatt tgtccgtcga agcctttcaa gtcctagtgt 2593321 tgctattaat ctgttttcgt catgcagcgg gactagatcg gcaatggtgc cgatagccgc 2593381 caggtcaagc agttcatcag gaagttcacc caataaagcg tgggcaagct taaacgcgac 2593441 tccaaccccg gcaagctctt taaacgggta agtgcagcca ggctgcttcg ggtggacgat 2593501 cgcacggaca tccggaagct ccggtcccgg ttcatgatga tcggtaatga tgacatccag 2593561 tccgagttcc tttgccacct tcgcttcatg cacagcggca attcctgtat caaccgtaat 2593621 gatcaaagag aagccccgtt ctttaatcga acgaaacgcc tgttcattag gtccatatcc 2593681 ttctttaaaa cggtcaggta tataaaaatc aacttgagcc gacagttttt gcagcgtgtg 2593741 aagcatcact gacgtacttg taaccccatc ggcgtcataa tcgccatata tcataatctt 2593801 ttcttgttgt gaaatcgcct gttttattcg atctgccgct tctttcatgc ctttcatttc 2593861 aaaaggatca taaaaatcgg catcctttgt atgtaaaaac agcctagcgc tttctgccgt 2593921 atcaaagcct ctttttacaa gcagggacgc aacaagaggt gttatatgca attgttctgt 2593981 gagtgatttg accttatcct gatctggtcg ctggatttcc catcgcattt ttgacgctaa 2594041 cataaattca cccctcaacc accctattat actagagcag gctgaggggt ttcaaataat 2594101 attcgaaaac tagtcttttt tctcaatcat ggctgatgca tcctgtgtgt cagtctgatc 2594161 agcaagatga gtatcctctt gtttatgtat tgctgttcta ttttctttcc gcaaggtttt 2594221 tatttcccgc ttcaatttca ttacctgaaa aatgccgaca gaaaatacga tcagtgctcc 2594281 cattaaaact gagcccaaaa taacaagaat gagcggccat tctgatcttc caaacaggta 2594341 atcaacttct acggatcgaa cattaatgac tgcgaaaata gcgacaatta aggtgaaaat 2594401 aagtgcgaaa ataatggtcc attgtttatt cattctcttt tcccccaaac ttcttattga 2594461 ggtaactttc ccaatcaaga ctggttttaa acatggctta acactaggtt aagctccctt 2594521 tgctgttaat ttttcccgga tcagcctctt cagtccggtt ccctcaccgg aaatcacaag 2594581 tgtatcgcct tcgtcaatga ctgtttcaga gctcggattc agttgtttat cctgattctt 2594641 tttaacaatt gcaatgaccg tcacatgata ttcctgaccc acattcaaat caccaatcgt 2594701 ctgatgaatg gcaggcgctc ccgcctctgc tttacaccac tctataatca aatcatcaag 2594761 ggctgactcg acctgttcta atgctttcgg tttatatgcc attccgccaa gaattgcaga 2594821 catttgcctt gcttcagcgt catcaaactg cacggaggca acacattcct catggtcgtt 2594881 ttcgtcaaaa tagtaaagct ctctccgtcc gtcatgatga atgataattg aaattttatc 2594941 acggtttcta gtaatcattt caactttttg tcctatgccc ggcagctctg attcgcgaac 2595001 cctcatatat aaaccctcct acatatctga aaaccagcca taaacacttt taacaccata 2595061 tatatgttta aatgtaagcg tatgtcatta tagcaaatgt ctattttaag ttcaatgaaa 2595121 cttcaaaaaa caggctgccc tgcagaggac agcctgatat tttttattgc gccgaatctt 2595181 ttttcagttc tcttcctttc catgcaagcc aaatttgtgc ggcaatgtat agagaagaat 2595241 aaacgcctgt taacagcccg accaataaag caattgagaa gttagtaata gaagatgctc 2595301 caaagatcag caatgtcaca acaacaatca caacggttaa tacagtgtta attgaacgtg 2595361 taaaggtttg ctgcaggctc aggtttacaa tatggttcag atcggcaaag gttttcggct 2595421 tacgcttttt catatgctcg cggaccctgt caaatgtaac gattgtatcg ttaatggaat 2595481 acccgattat cgtcaagatg gccgcgatga atgtaacatc tacctcaagc cttgtaatac 2595541 tgaagaacgt gacgataaag aatgcgtcat atagcaatga ggcgatggca gcaatcgcca 2595601 ttttgtattc gaatcggatt gaaacgtaaa taatgatgcc aatagaagct atagcaactg 2595661 cgtacagcgc atttctcgcc agctccttac cgactgtcgg tgaaactgtg ctgacatttg 2595721 gatcagatcc gtatttgtct ttaaaatacg tttttacttt tgcaatggtt tctttatctg 2595781 gcaccccgac aaaacgggca acaccgatat tgctcttttc gcctgacaga actacagtat 2595841 cagggtccat acccagagat tcaaaatcct tctcaacttg ctctgtcgtc agcttatggt 2595901 cgctttgcac ttcaatccgt gcaccgcttg caaagtcaat gccaagattc agcctgaaca 2595961 caagcaggat aataatcccg gcaaccgtga ccgcactgga gaaaataaag aagtatttgc 2596021 gtttgctcgt gaaatcccat ttttggaatg gcgtatgcgg ctctgtattt tcatccgtat 2596081 cctgaatatc catgatatgt ttcttattga caccaaacca gccttttttc cgatcaagcc 2596141 atctgctttc cacaaggaga gcgaggagaa atctcgataa gaaaacggca gtgataaagc 2596201 ttgtcaaaat cgataggatc agcattgtcg caaacccttt aacagagctt gtcccaaaga 2596261 taaagagcac aaccgctgca ataatggttg taatattcgc gtcaaaaatc gtcgcaaatg 2596321 accgtctgtt tcctgaacgg aaggcagagc ggactgactt tcctagcttg agctcttctt 2596381 taatccgctc ataggtaata atgttggcgt caacagccat cccgacacct aaaatgagag 2596441 cggcaattcc cggaagcgtg agtacggcat tcatccagtc aaagatctgg agtgtaatgt 2596501 agatataaac agacagcgta atcaccgcga ttaatcccgg cagacggtaa tagaaaagca 2596561 taaataagaa aataattgcg ataccgacaa taccggcaaa caccgtatca tggagagcct 2596621 gctggccgaa ttgcgcgcct actgatgtcg aatacttttc agtcagtttc acaggaagtg 2596681 cgcctgcgtt taaaatgctg gctaaatctt tcgcttcttg agctgtgaaa tgaccttcaa 2596741 tttttacatc agttgtattt agttcctgac ttacatttgg agcggataca aatttaggat 2596801 gctctttttg aacttctttc ttaaaggaat cacctttatc ataatccaac caaatgacaa 2596861 gctggttgtt tggcgccatt ttcatgacct tcttggtcac ttcaccaaat ttatcagcgt 2596921 ctttcagctt aatcgtgaca attggctcat ttgttgtgct atcataagtt tgtttagcgc 2596981 cgttttcgac tagatcagca ccgtttaaca gttccttatc atttgcatct ctgaaagaaa 2597041 gctgcgcttc agtcgccaaa atttcacgcg ctctgttttg gtttgtcacg ccagcgagct 2597101 gaacgcgaat ccggttattc ccttcaattt ggatgttcgg ttcgctgaca ccgagaacat 2597161 tggcccggcg gttcagtgcc tctactgtgc tgaccagaac gtcttttgtg attttgtcac 2597221 ctttttttac aggctgtaca tcatacagca cctcaaatcc gccttgcaaa tccaatccta 2597281 acgtaatatt gttagcggca ggcttcgtaa agtagcccaa gcccgtgccg atcaatagaa 2597341 cgaaaaggaa aaacgcaatc aagcgtcctt ttttcattat gtatatcctc ccttaaacct 2597401 gtgcgaatca acctgctatc tcagcagttc ttccaatgct tcctggccct cttcactgcc 2597461 cagccaatta gacgttttaa atgactcaac ggttgcatag ttcataaatt cgccaatttt 2597521 cactgataaa atatcactcg ccagttcata aatgctcagt tccgttttct ttttccactt 2597581 cttatctgtt aagtatgacc acaaactttc gagttcaaca tcatcatacc cgagaatctt 2597641 aaactcttcc agtttgctgt aaagaaacgg cctgacgtgg tctttatata gatcggctgg 2597701 atgcttctcc acgaattcca cgctcctttt ttattgtttt tcaagaagac ttgtcatgct 2597761 tggacgacat atacgcatat ctttattgta tatgattcca ggtagtttga gaaggcaggg 2597821 ggtaaaaatg gcgaaacaga cgtttttaaa gggcactctt atccttatcg cagcaggaat 2597881 ggttacaaga atgctcgggt ttgtcaaccg ggtggttatc gcccgtttta tcggtgaaga 2597941 aggagtcggg ctttacatga tggcagcgcc tactttcttc ttggccacta cattaactca 2598001 attcggtctg ccggtcgcga tcagcaagct agtcgctgaa gccagtgcgc gcggagatca 2598061 tcaaaaaacg aaaaatattt tagtcatgtc tctgaccatt acgggagtgc tcagcctcat 2598121 ctttacaccg ctgtttctgt ttttcgcccc tgttatggct gaaacgatgc tgacagataa 2598181 gcgaacactg tatccgctct tggccattac gcctgttgtg ccgattattg ctatatcgag 2598241 tgtgctgagg ggatactttc aaggaaaaca gaatatgaac ccgcttgcta tgtcacaagt 2598301 ccttgaacag gttgtccgca tttcactcgt ggctgtctgc acaacgattt ttctccctta 2598361 cggaattgaa tatgctgcag cgggggcaat gctatcctca gtggcagggg agctggcatc 2598421 acttctttat ttattcgttt gctttaagta taaaaagaca attaaaatca gaaagcattt 2598481 tttacagtca attaaaaacg gaaaacaaac ctttacccaa ttaatgagcg tgtcccttcc 2598541 aacaaccggg agccgcttta tcggaaacct ctcttggttt ttcgagccaa tcgtcgtcgc 2598601 tcaaagcctt gccatcgccg gtgtggcaac agttgccgca acaaagcaat acggggaact 2598661 aaccggcttt gccatgacgc tgctgactct gcccagcttt attacatatt ctttgtcgac 2598721 cgcgcttgtt cctgcgatca gtgaaggaat ggagcagaaa aaattgcagg tggtggaata 2598781 ccgcttagaa caggcgatgc gtctctgtct gctcagcgga ggcatttcag ttgttatttt 2598841 atttgtattt gcggatgagc tgatgagagt gatgtacggt tcctcaggcg cagctgtatt 2598901 tataaaagtg atggccccgt tttttctgct ttattatttc caaggcccgc ttcaagctgt 2598961 gctgcaggcg cttaatttgg caggagctgc gatgatgaac agcttaatcg gagcgcttgt 2599021 caaaacaggc cttatttttg tccttgccac aaggccttct cttggcatta tgggcgcggc 2599081 attagccatt gtgacaggca tggtgctcgt cacgctattg cacgcagcaa ccgtaagcaa 2599141 agtgctgccg atcagcatca aaatcaagga gtacgcgctc agcttcgctg ttattgtaat 2599201 ttgcggattc atcagctccg ccatcaaaca atatataagc tttggagcat ctgaggctgt 2599261 caatctagcc ggatggattg cggcgagcgc cgccatttat atgatcctcc tgctcgtttt 2599321 ccgtttaatt aaaaaagatg agcttcgccg cattcccatt atcggacggt tgatcatccg 2599381 ataatggtca cgtgcggtgc ccatcttttt catcaatata tatttctccg tctgtaaacg 2599441 agcaaaatga aatatctgaa gggtttgtgt atccgtgttt ttgcaaactt tcaagcagcc 2599501 attttctatc tttactgatt ctggacaggt tttctgtttg aatgaagccg tctataatga 2599561 gcggcatttc gagctgccga tgctctccgc tgttttcttt cttaacaata gtcagtttgc 2599621 ccgacggctc taaaatagca aatgatacgt cagctactct gtcgatgcta ttttctctga 2599681 gctgaaccat taaatcatca aaattataac gctgtgattt catggcttct tcgtcaattt 2599741 ttccatattt gataattatg gtcggcttac cgtcaagaag ctggcggact tttcggtttt 2599801 ttaaagaaaa gtatgccaaa gtcacttgaa tgatcattaa tacaagcatt ggcaaaatgg 2599861 tatgaaatag atgatcgtct acgttttcta tggctaaaac ggcaatttca gccatcatga 2599921 taaagacaac gagatctaaa atactaagct ctccgatctc ccgtttgccc atgaaacgaa 2599981 aaatgaccaa tatcacaaaa tacaatacga ctgtgcgaaa cgcaatagtg agaagctctt 2600041 ccattatgca cctccaactc attataggtt gcaacaaaat gatcaattta tgtaagaaaa 2600101 accgattgca tttcacaaag cttttacgtc taattcatgg gataagggaa tacattttta 2600161 caaagacgag ccatcagcat gtctgacggt tttgaacaaa aagaacagaa gccttttaat 2600221 acaggcagag aggagacaat catggaggaa acgaaacaag ttggaaaagg cattctttac 2600281 ggcttaatcg ccatattttc agccatgctc ctgacaagtt tagcggtttc acttttattg 2600341 accgcaacct cgctggaaga atcatcattt aactggctga tcaccgctat ctcatttctc 2600401 tctttattta tcggcgggtt catttcaggc gggaaaggca aggaaagagg ctggatgatt 2600461 ggcgcattga ccgccttaag tttttctctg attatcttat tgtttcagta tttaggattc 2600521 ggaaagacat ttacagcaga acagctgatc ttccatctgg gatttttagg ggtgtgcatg 2600581 ctgggcggga ttttcggcgt gaacatgagg ggaaacaggt cttccacata aaaaagagcg 2600641 ggctcacttg cccgctcttt tttgtttgct atgtatagct cctgctgtta ttcagcagca 2600701 gaaacttctc tgatcgcgcg gcggtcgaac gtaagacgtg tgttatcacc agtcttaatt 2600761 acgactttgc tttcgtcgat agagtcaaca gtaccgtgca atcccccgat tgtcactact 2600821 gaatcgcctt ttttcagttc ctcttgcatt tggcgtacag ccttttgctg cttttgctga 2600881 ggacgaatca gcaagaagta aaggaccgca aacattaaaa taataggaac caatgtacct 2600941 aaagtgccag tcatcatttt cacccctttc tgtaagcctg ttatgtttat ttagaagctt 2601001 ttcgcatttg gcttgttata gccgtaacgc tcaaagaact cttctctgaa atcacccaga 2601061 cgatcctcgc gaatagcctg tcttacctgc tccattaagt gtaacagaaa atgaaggtta 2601121 tggtaagttg ttaatcgaag gccgaatgtt tcattgcagc gaatcaagtg cctaatgtac 2601181 gcgcgagtgt agtttttaca tgtatagcaa tcacactctt catcaatcgg acggaagtct 2601241 ctttcaaatt tcgcattttt catattgagt cgtccttcag cagtaaacac tgtgccgttt 2601301 cttgcaatcc gtgtaggcag cacacagtca aacatatcga ccccgcggat cgctccgtcg 2601361 atcagtgcgt ccggagaacc tactcccatc agatatctcg gtttatcctt cggcaagagc 2601421 ggtgttgtga attcgagtac acggttcatg acatccttcg gttcacctac agacaatccg 2601481 cctatagcat atcccggaaa atcaagcgaa atcaagtcct tcgcactttg tgtccgcaga 2601541 tcttcatatt ctccgccttg tacaatacca aacagccctt gttcatcctg acgattgtgg 2601601 gcattcaggc agcgttccgc ccagcggctt gtccgttcaa ctgacctctt catgtagtcg 2601661 tactccgccg ggtatggcgg gcattcgtca aacgccatca taatatcaga gccgagtgcg 2601721 ttttggatct ccatcgcttt ttccggagat aaaaacagct tgtctccatt tagatgattg 2601781 cggaaatgga caccctcttc ctctatatta cgaaacttgc ttaaagaaaa gacctgaaaa 2601841 ccgcctgaat ctgttaaaat tgcgcggtcc cagttcataa atttatggag cccgcccgct 2601901 tctttgacaa tgtcttggcc cggacgaagc catagatgat aagtgttgct caaaatgatg 2601961 cctgcatcca ttgctttcag ctcttcaggc gacattgttt tgactgtcgc cagtgtgccg 2602021 accggcataa aaaccggcgt ttcgaaggag ccgtgaggcg tatgcacttt gcccagccgc 2602081 gctcctgttt gtttgcattc ttttataaat tcatagcgta ttggttgttc agccactttt 2602141 gatgaggcct cctgttctca aattatataa tcagcatcgc gtctccgaag ctgaagaaac 2602201 ggtattcctc ttccactgca tggttatagg cacgcagaat gttttctctt ccagcaagcg 2602261 cgctgaccag cataatcaat gacgatttcg gcaaatggaa gtttgtaatc attccgtcaa 2602321 tggctttaaa ttcatagccc ggataaataa aaatagatgt ccagccgctt gatgctttaa 2602381 attgcccgtc atgttctccg gcaatcgtct caagcgtgcg tgtcgaggtc gtgccgacag 2602441 aaatgatccg accgccattt tctcttactt tgtttaaggc tgcagccgtt tcttctgaca 2602501 tttgataaaa ctctgcatgc atattatgct cttccacttc atcggcactc acagggcgaa 2602561 acgttccaag gcctacgtgc agtgtgatga actcaatttg cacgcctttg tctttcagct 2602621 gctgtaagat ttcttccgtg aagtgaaggc cagctgtagg cgcagcagca gagccaattt 2602681 cttttgaata cactgtctgg tagcgctctt tgtcatcaag ctgttctttg atatatggag 2602741 ggagcggcat ctctccaagg gattcaagca cctcgtagaa aataccgtca tattgaaatt 2602801 ccatctttct gccgccgtgc tcaagctctt ccgtgcagat tgccttcaat cttccgtctc 2602861 caaatgtgac aacagttcct tttttcaccc gtttcgccgg tttggcaagt gtttcccatt 2602921 tatcaccggt ttcctgtttc aacaaaagaa gttccacttt cgcgccggta tcctcttttg 2602981 tgccgaataa ccgcgcaggc agtacccggg tattgttcag gactagacaa tcgccttcgt 2603041 taaagaagct gataatgtgt ttaaacgagc tgtcagtaag ctctcctgta tgtttatcga 2603101 gcaccatcag ccttgaagca tcacgctgct ccaacggtac ttgtgcaatt aaacgttctg 2603161 gtagttcaaa atcaaataaa tcgactttca tgatgatttc acctttattc tagtcttttg 2603221 ttatttcatt ctgccaaaaa gattaagcaa aattgataat accacactta taataataca 2603281 agtgacaacc gggaagaaaa acgtaacatt tccttttttt acaaaaatat ctcccggcat 2603341 cttgccgaca aaatgcaaaa ctgctccgat aataagcaaa acagcaccaa gaatcataat 2603401 gatcttagga aattcagtca tatcggggag cctccatttg gaaatgatga taaacggccg 2603461 gtgtcacgat ccttccacgc ggcgttcttt gtataaatcc aatttgcagc agatatggtt 2603521 catatacgtc ttcaatcgta tgcgattcct cgccgatggt agctgaaatc gtatcaaggc 2603581 ctactgggcc gccgttgaat ttttcgatca tgcccatcag cagcttatga tcaatatgat 2603641 ccaaaccgag gcggtcaacc tgaagccgct ccagcgcatt ctgagaaatg tcttccgtaa 2603701 tcctgctgtc acccagcact tgggcgaaat cgcgcaccct tctcagcagg cggttcgcca 2603761 cgcggggcgt ccctctcgat cttcttgcaa tttcaagagc cgacggttta tcaatctcaa 2603821 cctcgaatac atcagcggtt cttgtgacaa tatccgccag ttcttcttgt gtatagtact 2603881 caaggcgaga cattacgccg aatctgtctc ttaaaggagc cgtcaaaagc cccaccctcg 2603941 tcgtggctcc caccagcgta aaaggcggaa ggtcgaggcg aaccgagcgg gcagatgggc 2604001 ctttgccaat cacaatgtcc aggcaaaagt cttccattgc aggataaagc acctcttcga 2604061 tcgatctgtg cagcctatgt atttcatcaa taaataatac atctcccggt tccagcgccg 2604121 ttaatatagc agccaaatca ccaggccttt caatcgcagg ccctgatgtc gtccgcaatt 2604181 ccactcccat ttcattagca acaatcgaag caagcgttgt ttttccgagt ccgggcggcc 2604241 cgtacagaag aacatgatcc agcgtctcct gtctcatttt cgccgcatct ataaacacgc 2604301 gcaaattttc ttttacctta tgctgcccga tatactgtgc cagattttgc ggcctcaggc 2604361 tttgctctat cactgattca tggttgtctg cttcacttga gacgagccgt tcatccatga 2604421 acatcacctt actttaatag tttttgtaat gcttttttca catattggtc tgttgtcagc 2604481 ccaatttctt ctttaaggtg aggaagcacc tttttgattt ctttttcagc atatccgaga 2604541 accctgaggg cttcaagtgc ttcttcaaga gccgtttccg ctgtttgctt ttcaagcctt 2604601 tcttcatgat taaacagatt ttcaatcatt tcaggcacaa catctgccag ctttcctttt 2604661 aaatctagaa taatctggcg tgcggttttc tttcctactc caggaaactt gaccaaaaaa 2604721 gcttcatctt cattttcaat tgcttggatg accgctccgg gatcacccga gcccaagatg 2604781 gcaagtgctc ctttcgggcc aattccggtc acgtttaaca gctttgtaaa gagcgccttc 2604841 tcctctcttg ttgaaaaacc ataaagcgaa aaagcatcct ctctgatatg atggtatgta 2604901 aaaatcgttt cttggcttct ctccttatat ataaacggat tcggcgtgaa aatctgatag 2604961 ccgatgccgc cgttctctat gacaatatat tggggagata cataatcaat cgtcccttta 2605021 acaaattcaa tcacgcaaat tcacctcttt gactgttctt cattgtacca taaaaacagc 2605081 caaagtctta tagaaaagtt aacatatgtt cgcttctctc tcattctttc acgaaaaaaa 2605141 agacatgaat acatgtcttc aatcagcgga cgctacccgc tgtatgtctt catatgttcg 2605201 atgacatcct caaactccgc ttttgtccga aatggaatgc ctttcagcag atttttttgc 2605261 atatggcttt ccagcctttc taaatcaatt tgaaaaaaag actgaattgg ttcggaagct 2605321 ggctcaggcc gcccatgaaa agtggaaatc actccattat ccgatacacc gatatacccg 2605381 ttgaccttgc tgagcggaga aatatcgtcc atttgcttcc ggaagagcac atatcccttt 2605441 ttttgttcca ctagcgtcca tccggcataa gctgcccaaa aatcatccat agaaaacact 2605501 ttttcatgct tatgctcaat gctgacatcg ccgtccaaat acaccttttc aagctgcaca 2605561 tgcacctgca gcggctcata gtgctccact tccgcgccaa gtgcgcggga aggagctcct 2605621 attaaaaata ctgccgctga gcaaagaatg cccagcaaaa gatacgccgt gctgaatcgt 2605681 ttcaccctct acacctcttt gcacacgttt atgattagtt tgaccaaaga ggctactgct 2605741 taaccgtttt atcaaaattt gtctgcacat tttccctgac aaaccgttcc tccgtataca 2605801 catctgtgct ttgctcagaa attgtcaaga atcgcgtcag aaaggcactg aaaaaataca 2605861 atgccgcaaa gatccaaatc acgccacctg caccgagcgg cccaatgaaa agactcacga 2605921 tgcccggcgc gataaacgca cataaaccag atcccaaatt caacactgac atggcagcac 2605981 ctttattatc aggtgcaagc gtcggcaaaa gcgcgcttaa tgggacgtac cctgctaaag 2606041 ccgcgccgta gcagcaggcg ataatcatga gcacccaata ctgatgcccg atcagctgag 2606101 gcgtgtaata cagcgccagc gtaaaaatac cgcatccgac accgccaaac cacatgaccg 2606161 tattgcgcca gcctagttta tctccgactg caccgaaaat gatattaaac acaatattca 2606221 caaaaaacag cgtcccccat atttgcagcc attccgaaac cgaatacccg tatcgtgcta 2606281 aataagtagg aagaaagatg gcaaatccaa attgtcctat cgcattaatc gtcttgacca 2606341 ctccgccgat gcctacctta gggttttcaa acataatcgt aaatgccttc gacagttctt 2606401 tccatttcgg ctgatcttgt ttttgtatcg gagtaaattt atctttgtta aaaaataagg 2606461 caagaattcc gcctgccgcc acaaacagta aagcgctcca aagcgtattg atttctccaa 2606521 aggccggaac tgcatagctg gaatagaacg gaccgagcac gttaaggccg cacgtaaaca 2606581 taaaccaaaa ccagccgacg gcttttccaa gaatattttg agaggtgctg tatgacaccc 2606641 atacgagaaa agagtatgca aacagcggat atcccaagcc tctaagagca tagctgccca 2606701 agagagccgg ataatacata tgaggaatcg cccagccgat aaaagcggcc gaaccgagga 2606761 taaatgcaag caatccgaca gtcatcgttt ttctcggccc ccaagtttgg acaaacgttc 2606821 ctgaaagcca agctgagatg gtgacagcaa tgccgtacat ggtaaataac gatgcggatt 2606881 gctgcatact gagaccatga tcaacgagaa aaggagacag ccagccttgt tcgaggccgt 2606941 ctccaaccat aaagatgaca acgccaatat aaccccaaac catgtgagaa ggaattccga 2607001 ttttgttcaa aacatttcct ttagcatgta ctgtattcat tttctccacc gcctacttaa 2607061 agtatcaatg gagtatatac ccaagcttgc tgaattgtaa tcctgttaga ttaaaaagcg 2607121 attttttcag tgtgctcaat gctaacaggc atgccaaaag caagcgattg ctgtgctgct 2607181 ctggcgatcc tcccggcctg taaaccgtca ttgccggtgc agggagtctc ctggtttgtg 2607241 ccgatcgctt ctgcaaaacg gagaatctcc tcctcatatg aatccttata gcgttcaagg 2607301 aaaaagaaat gcggtttatc cttcatcaca aaatcagctg ttgacacctc aaccgttgtc 2607361 ggcctgctat tgtcagccgc tgcagagcct ttcgtcccga aaacctcaac ccgctggtca 2607421 tatccgtaca cagcttggcg gctgttatca atcacagcca tggcaccgtt ttcaaaagtc 2607481 agtgtaataa cagctgtatc aatatcaccc agctccgcaa aagaaggatt caccaaagcc 2607541 gcccctttgg catacacttc cgtcacttcg cttcccataa tatatctggc catatcaaaa 2607601 tcatggatcg acatatccat aaacaatccg cctgacgtac ggacataatc tatattcggg 2607661 ggttctgggt cccgggacgt gatttttaat aaatgaggtg taccgatttc accattttca 2607721 acaatcgttt tgattttctt aaaatgagga tcaaagcggc ggttaaatcc gacttgaagt 2607781 gttaccccgt gtttccggac agccgcaagc gcttcactcg tttcgtccag agagaaacta 2607841 acgggcttct cacaaaatat atgctttttc gcctcggctg cttctttgat catctgtgca 2607901 tgtacggctg taggagagca aataaaaata gcatcaatat caggatcatg taataaatca 2607961 cgataatcag aggttatgta ttcaatctga tgactgtcgg cccagctttt tatacggctc 2608021 gcctgaatgt cagagattgc ttttattttc atgtgaggaa tccggcttat attttgaaca 2608081 tgaagtttgc cgatgcggcc tgcaccgata atccctgtca caatctgttt tgtcatggct 2608141 tcttccccct tgatcattca cgaaagcgct ttatttaaaa ttaatactat cccatttgta 2608201 agcgcttttc aagaatggaa attaaacgtt ctatgtctct tttatcacaa ttcatgctta 2608261 taagtagcct tcttcttcaa gaccagatac actagaatta ggctcttttt cctgaacagt 2608321 ttatgatttt cctataaaca gctgcataaa atagagcaaa gaaggtgaat gaaatgctga 2608381 caaaagcaga ggcactggcc cataccgtca tataccgcaa gaacagcaga tttgataaag 2608441 tcaaagagaa atccgaggaa ttaacactaa tcggcaaggg aagaagcgcc tatgtgtttg 2608501 ccttaacaga aggcggtcga aaaatggcgc tgaaagtatt ttttccggaa tatcaagcga 2608561 cagcagtcaa agaagcagcg atctatgaaa aattagccgg gtccgcattc tatcctgaca 2608621 tttacgaaac tggcgattca tttattctca tggaatatat taaaggtgaa accttttata 2608681 actgtctgaa gaaaggcatt gcaatcagtg atgacatgat tcagcaggtt gaagaagcgc 2608741 tttctgacgc ccgggcagcc ggactgaacc cgtcagatat tcatttgcgg aatctgatat 2608801 tgacagaaac cggggcggtg cgggtgattg atgttgcgag atttgagcag acaaaaacat 2608861 gcacgcagtg ggacgactta aaatccgcat atcatgcact ctacaaaaaa ccgatattcc 2608921 ccaaaaagat tccgggtttt tggctggaga tcatcgcatt tttatataag aaagattggt 2608981 ttcaaaagca tttcgcacag cggaaaagaa aatattctta aatcaaaaag gcagccgcac 2609041 aagcggctgc ctttatcatg tattttttac tttctgacgg cagaaatcag tttcatttgt 2609101 tcaggcgaca gcttaattcg atagcctctc acagttaagt agaccgcttc tgggtccttc 2609161 tcgccggaat gacaatacgt tttttccatt tctgtctccc ctcacccttt attggcttta 2609221 tttcatctta tcattgcttt attgaggtaa ttttaaagaa atgtaaagat tatatgaatc 2609281 cgatatatag taaaatgaga gaaaaaaagg gagagagtca cattaagacc gaaaacacct 2609341 tgagcttaga tgcagccaga ggtgaacttg taaatgaaaa aacacttgtc aagagaacaa 2609401 tctactggaa ttacccggac agccgcccag cagtgacgtg gatcaatcac aatacagtga 2609461 aaatcggcaa tcagacttta catcttgata ctgatgaaac gtatgattgg cgaaaagatg 2609521 atcattggat ccgtgaagaa ccgccgcagg cgtcagtgag gtgatgaaac atgaataaga 2609581 tgaacggaac aaatgatgaa aagcatttca atcattttgt gattgcttta tcctttatat 2609641 acggtttgac tgaactaggc tatttgttgc tgaaggattt tataacaatt gccataagtt 2609701 tgcctctgta gaaaaacgca gcgtagtcga tacgccgcgt tttttctttt tcccttcctc 2609761 ttcttattga taattacagg tcatataatg tgacaaatcg attgtagaaa tagttcgatt 2609821 agaccaaaat cctttttata catgtattcg aatttgaagt gagggggaag cttgatggca 2609881 gattttgttg ctagtttgaa tgcggtctta tggagtacgc ccgtcattta tattttattg 2609941 ggaattggat tcgccttttc aattatgacc cgttttttac aagtccgaca tttaaaagaa 2610001 atgattgttc agatgttcaa aggcaagagc tctgaagccg gcgtttcatc tttccaagcg 2610061 ttatcgattg cgctgtccgg ccgtgtgggc acaggaaaca tcgcgggagt ggcgacagca 2610121 attgcattcg gcggacccgg tgcagtgttc tggatgtggg cgattgcctt tatcggggcg 2610181 gcgagtgcct ttgtagaatc aacgcttgct caaatttaca aagtgaaaca agacggtcaa 2610241 tatcggggcg gccctgctta ttatatagaa aaaggcttag gcattaagtg gtttgccgtc 2610301 ttatttgccg ctgctgccct tattgcaatg gcctttctaa tgccgggcgt acagtccaac 2610361 tccattgcgg ctgggatcca aaatgcattc ggcatctctc ctttcgtcac agggtgcggt 2610421 ctggttttat tattagggtt cattattttt ggcggcgtca aacgaattgc caatgcggcg 2610481 caaatgattg ttccatttat ggccattgga tatatcctgc tgtctttgat tattattgtc 2610541 atgaatgtgt ctgaattgcc tgctgtgatc tcattaatat tcaaaagcgc cttcgcattg 2610601 gattccgctt ttggcggctt gatcggtatg gcgatttcct ggggcgttaa acgtggcatt 2610661 tactcaaacg aagccggcca gggaacaggc ccgcatccgg cagctgctgc agaggtttct 2610721 catccggtca agcagggact ggttcaggca ttttctgttt atattgacac cttgtttgta 2610781 tgttccgcta cagctttcat gatcttgttt accggcatgt acaataccca ggctgcagat 2610841 ggttccttta tcgttcacca gcttaaaggc gtagaagcag gacctggttt cacacaagcg 2610901 gcaattgaca gtgttcttcc cggattcggt gcaggctttg ttgccatcgc tttattcttc 2610961 ttcgctttta caacaattat ggcgtattac tacatcgcag aaacaaatat cgcctattta 2611021 gcacgaggca gagaaagcaa atgggcgatg cttggcttaa aactgattat tttagccgcc 2611081 acgttctatg gtactgtgaa aacagcttca cttgcttggg cattagggga tgcagggctt 2611141 ggcattatgg tatggctgaa cgtcattgcc attgtgctgc ttgccaagcc ggcgctcctt 2611201 gctttaaagg attatgagcg ccaaaagaag cagggcttag acccgatctt tgatccaaaa 2611261 gcgctgggta tcaaaaacgc tgatttctgg gagaaagaat acactcatga aagtgaacgt 2611321 gtctcctgaa catactaaaa ccggcccgat atgacctcgt gccggttttt tatgaacgat 2611381 agtttgtata cacttcttga acatcatcgt catcttcaag gacgtctatt aatgtttcca 2611441 gcttctcaac agcctgatca tcggcttctg cataggtatt gggaagcatg gtcacctccg 2611501 ccgaagaaat tagatatttc gattcgaggg ctgttttcac ctcttcaaaa tgctcaggct 2611561 ctgtgaaaac ctcatatagg tcttcttcaa ttcgcagctc ttctcctcct gcttcaagca 2611621 catcaagcat gagctcatct tcttctattt gccgttcagt acggtctatc gtaatgaacc 2611681 cctttcgttc aaataaaaag gctacacatc cgctttctcc cagacttccg ccatttttat 2611741 taaaggctgt ccgcacattt gacgccgttc ggtttttatt atctgttacg cattcaacca 2611801 tgacggcaat ccctgaaggg ccgtagcctt cataggtgat ttcttcatag ctgcttccgt 2611861 cttggcctcc cgcagctttt ttaatggccc gatctatatt ttcattcggc atattggcgc 2611921 cttttgcttt ttcgatgaca agacgcaatg ctgaatttgc ttctggatcc gctccgcctt 2611981 ctttcgctgc cacatagatt tcttttgcca gcttcataaa tattttcccg cgctttgcat 2612041 cctgtgcatt ttttcttttt tgaatgtttt tccacttgga atggcctgcc atgttttcac 2612101 cttcttttac attttctatg tacactttaa tgggaaatgt tcgctgatgc aaagaaaaag 2612161 gctgccgaat atcacttccg gcagcccttc cttcctagcg gttgttcatt ttatgaagtt 2612221 ttctgaacag ccctttatct gttgatactt ggacgtcacg gccatttgca tagttgcgcg 2612281 ctgcttttac aacattatct ctgtcagact ttgtgaactc tctgtggctt ttgactgcga 2612341 taactactcg gtcatccgat accataactt gtgtgtcatt gacgtttttc acttgtttca 2612401 cacggttggc aatttttgca gccagtcttc tgttttcttg gttgtcatac ccgttgttcg 2612461 ctgcattccg attcatgttt cggttattcg tgttgttata tgttccgtca gttgccaaag 2612521 gaacacgatc gtcagcagta acacggtcac ggttatttac attcgtggtg tttcggttac 2612581 cgtcgttctg atcctccatt aattcagaaa caggaccatc gtggtcgatt ccgtctccct 2612641 gtctatcggc gtcattttca tttgtataat atccgattgg acgggtattg ccgttattgc 2612701 gcgtatcatt catagcatta tcgtttgctc cgcatgctgt taagccggct gtcattagaa 2612761 tcaggctagc gatcgtcatt tttttaccca atggaaaaac cccccgtgga cgaattgagc 2612821 atgtttgctc gcttttatca tgtgcgtatg gggggcatgt taagcgtgtc agttctctcc 2612881 atttggcagt gatctgcttg aaaacaaaaa aaggaacgat ttacatcgtt ccgaacgatc 2612941 actcattttc ttcttccgga cggccaaaca tttggtttac agaaggctgg ttcgtcattg 2613001 gcatagaaac tcctgccgaa tatgggtttg gatttgggtt agctgtgcca tatggcatat 2613061 tagggcttcc ataagctccc attcccgaat ggccaggtgc agagaaatat ggctgatgat 2613121 caccgtcaca gccgcagtcg tcatgatctt tgtatggcat gtaaccatga gccgcagcag 2613181 gctggtatgc tcccattact tggggagtgc cgtaataagg gccatacggc atatgtccat 2613241 acggagatcc ataagccgga gatgcgtatt gcggcgcacc gtatgaaccg taatgtccgt 2613301 gatggctgtt ttcatgatgc tggttttcat aacccgggtc atactgaggc gatacaaagc 2613361 ctggctggta tccatgcatc ggatgcattg gataagcttg tgccggatag tacggatagc 2613421 ataatcctga tcctggaaga attggcgaaa caggcaccgg acacggtacg aaatgagccg 2613481 gataatgata ataaggctga acagccggca tcggcatatt cggaactgtg tgatgaacgt 2613541 tttcctcttc tataccgcct acctctggcg cctttggcat attaggcata ttcggataat 2613601 ttgcattttc catattactc atagcctcct gttgtggaaa ttggtcttgc atatgataca 2613661 tatgatccat atttccgtca tgatgttttt tcggctcctc cggtttagga ggcgaccaag 2613721 gctggaaaag ctgtttcata tcataataat cgttcacatc agcttcaggg tacacatttt 2613781 cctgcaaatt aggcatcggc gggacatacg gcatggactt cttttctttc ggctttgtgt 2613841 cttctacatc gacaacggat ttaggcttct ctttcgcata tggatgttct tgcttcacac 2613901 tcccggccgc aggacttttg cccgcttttg gctcttttct gaccgggact ccttctgacg 2613961 gcacttttat tttcattcca ggcatgatta agtctggatt gctaagctgt gtattgagtt 2614021 ttttcacttc ctcaacatcg actccgtact tttcagctat tttccagagc gaatcgcctt 2614081 tttgaacgat atggattttc aacgttttcc cctcctatgc aaaacgtgaa cagttcagct 2614141 gtgattacaa tatgtttctt cacaacatat gcctgaacaa aagaagttat gagtaaagga 2614201 agggaaaata tttctgatct acgtgatcga aagcattcga ttcagggcaa ggagtgcatc 2614261 ttcctgaatg gcttttggca ccttgatgac gcctgaaggt tctccttttt caatttgttc 2614321 cagcgaccac aacaaatgcg gcaaatcaat tcggttcatt gtcaggcaag ggcacatgtc 2614381 agggttgagt gattcgattt gtttatctgg atgctcgtga atgatccgct gaacaagatt 2614441 catttctgtc ccgattgccc acttgcttcc cgccggagcc tggttgattg tgtcgataat 2614501 atatttcgtt gatccgttat catcgcttag tgtcacgact tcgtgtgaac attccgggtg 2614561 cacaatgatc tgaatgtcgg ggtctcgctc tctcatatca tggatatttt tagtggtgaa 2614621 tttctcgtga acagagcaat gccctttcca caaaatcact ttcacattcg tatgcccgga 2614681 ttcagctact aattcatctt tcatcggatc ccacacagcc atatcttcaa gcgcaatgcc 2614741 cagatcataa gccgtatttc tccctaaatg ctgatcaggc aaaaataaaa ttcttttttt 2614801 ctgtgtaaac gcccattcaa gcactttttt cgcattcgaa gaagttacag ttgctccgcc 2614861 atgctttccg acgaatgcct tgatctccgc agtggagttc acataagtta aaggtatgat 2614921 cgtatctcca aatatatgct gaagcttctt ccatgcccta ttggtctgct gcatgtcagc 2614981 catgtcagcc atagaacatc cagctctcat atctggcagg acgaccgttt gctgctcgct 2615041 tgtcagcata tcggcggttt ctgccataaa gtgaacgccg caaaatacga tataatccgc 2615101 ttctttgttt ttttccgcta cttgggccaa ttgcagggag tcgcctgttt ggtcagcaaa 2615161 ttgtatcact tcatcctttt gataatgatg gcctggtata aagagcctgc tgccgaactt 2615221 tttcttaatg gcggcaacgc gcgtttccat atcctttctc gatagttctt tataactttc 2615281 gggcatcata tcattcgatt gtttgatcac atcaagaatt gacataacag cattcctcca 2615341 cagattcatt tgataacgta acatccatgc tgatatctaa acttttgacg gaatgagtca 2615401 gaaatcctaa tgaaatataa ttcacacccg tccctttaaa agcaggcaaa gattctaacg 2615461 taatcccgcc agaggcttca gtttttatat tagccggtgt gagctttgca aaatgacgga 2615521 ccgtatcagg cggacagttg tcaaacataa taacatccgc tccagctgca attgcttccc 2615581 gcagctgttc ctccgtttca atttccacct cgatatttac catgtgccct gcggcctgac 2615641 gggctttttt gcacgcctct aaaatagagc cgcatgctgc gatatgatta tctttaatca 2615701 tgatgccgtc atacaaaccg aatcgatgat tatacccgcc gccggctctg acagcatatt 2615761 tctccagcat tctgagcccc ggtgttgttt ttctcgtgtc acaaatttta atctgttcat 2615821 catccagaca ccgaacagcc tctcttgtca ttgtcgcaat tcctgacagc ctctgaataa 2615881 gatttaatac gacccgctct cctgaaagga gcgcagctgc gggaccgtgt aactcggcaa 2615941 tcacttcacc tttatgcaac atgtccccat cttttttgtg taaaatgctt tgaacatttt 2616001 cgtccaataa cgaaaagcct tcttttatga tcgctgctcc tgcaaaaata ccctctgact 2616061 ttgcaacaat ctccgcttca cagctctgtt ctccaaaaat agactgcgat gtaagatccc 2616121 ctgtcccaat atcctcaaga aaaaagtgat tcagtaattt tttcagctgt aaatgattca 2616181 ttgttccaaa tcccctcgtt ttttctgatc ttcgttcctt tttttgtatg gacaatttgt 2616241 cttccttgcc agctcacctc agcatgagga aaatcggtgc ggaagtgagc ccctctgctt 2616301 tcctcccgca aaagcgcaga aaacgtcatc agctttgcag tttgccatag atgagaaagt 2616361 tccatctgcc gaattgtgat atccttcaca tttacttcct gaaaaggcag cgtatgaagc 2616421 cagatgctaa gctcaatcaa actgctttgt tcccgcagaa tagacatgtg gcttgtcatt 2616481 ttgctttgca gttcatgccc ctctatatcc ggcacctcgt agaagacact ggtttctagc 2616541 cctgattgat attgcctgtt ataaaccggt ttttggataa tatgctctgc tgcccttttt 2616601 ccaaatacca gcgcttccaa taaagaattg cttgcaagcc ggtttgctcc atgtaaaccg 2616661 gagcatgctg tctcgccaat cgcataaagc cccggcactg tcgtttctcc ccagcgatta 2616721 actgaaacac ctcccattaa gaaatgcatt cccggagcaa caggaatttt tccgctgtgg 2616781 atatcaatcc ctgctttttc acaaatagcg gtgatggtag ggaaacgcgt ttcaaaatca 2616841 gaaatcgcac tgaagtctat ataaacgcga tttccttttg ccatttcttc gtgaataacc 2616901 cgtgagacaa tatctcttgg agccaggtca cctaaaggat gccgttcagc cataatcctg 2616961 cggccgtttt cgtctactaa acatccgcct tcccctctga cagcttctga aacaagcccg 2617021 taggaaacac catttttcac aagcagtgtc gggtgaaact gagtaaactc caaatccgtt 2617081 aattccgccc cggcccggta agccagagaa agaccgtcac ctgtgacagt gagatcattc 2617141 gtatggtgaa gaaacaggtt tccacagccg ccggcagcca gcacaacttc gtctgcgtgc 2617201 cttaccttga gccgcccttt gctgtctttt gtcatgacgc cgatacatcg tccgtcctct 2617261 ataagcaaat ctgctgccgt ttcattctcg attaacttga ttttgctgtt gatccgtttg 2617321 agcaaataat cgataagcag cctgcctgtt gcgtctccgc ctgcatgaaa tatgcggttg 2617381 tatgagtggg ccccttctct tccaagacaa acaccgcctc gttcattgcg gtcgaatgga 2617441 aatccacgct ccaataggct ttgaaccatc atttttccat catgtaatac gtctgctaca 2617501 atagctagat tattatggcc gcaccctgcg tataacgtat cctccagatg ggcttcaatc 2617561 gagtcatctt ttgcataggc cgcagcaatc ccgccttgtg catagacaga attgctgttt 2617621 ttgacgcttt tttttgtgat aacagtcact tcgtatgagg gcgggaaagc tgcagctaag 2617681 gaaagtgccg ccgcccctga accgatgact gcaatcgtct ttttagacat atgccatcct 2617741 cctgttgttt acacctgtct tgacacctat atttacacaa ggataaaata aactcaagag 2617801 ttttttatgg agaacggatg gaggaagacc ggatgattta tttagattat gcagcgacaa 2617861 cgcctatttg tgaggaagcc cttactgtat atcagaagct tagtatggat atgtacggaa 2617921 atgccagcag cctgcatgat gcaggaggaa aagcaaagca catactggag tactgccgtg 2617981 aaaaaatcgc caacatcatt ggcggagaag caagcggcat ctattttaca agcggcggca 2618041 ctgaatccaa ttttctggcc attcaatcat tgttaaacgg cctgccaaaa acgaaaagac 2618101 attttattac gactgccatg gagcatcagt ccattcataa ttgcgctgct tttttggaac 2618161 agcagggata tgatgtaaca gtcattgaac cgaatgaata cgggcttatt accgaggaaa 2618221 tattactaac ccatatccgg ccggaaacag gccttgtatc tattcagcat gcaaattctg 2618281 aaaccgggat cattcagccc attcaacacc tgtcttcata cctgcacaat aaggggattc 2618341 ttcttcattg cgacgctgtt caaacgtttg gaaagatccc gatcaataca aaaaatctgg 2618401 gagtagatgc actctcaatg tccagccata aaatccacgg tcctaaagga gtaggggcgg 2618461 tctatatccg gccggatgtc ccttggaaac ccgtttatcc tctgactact cacgaatacg 2618521 gattcagagc cggcaccgta aatgttcccg ggatcggtgc cttcactgcc gctgcagaat 2618581 tgatcgtaag cgaaatggaa aaacagatat cccgcaatga ggcattaaga acatactttc 2618641 tagaccaaat ccgtattcgg tctctccctg taacccttgc agcagacact tcgaaagcag 2618701 aatgtcttcc gcatattata gggtgttttt ttcactcatt tgaaggacaa tatgttatgt 2618761 tagaatgtaa tcggagtaat atttgcattt caaccggcag cgcttgttct gcaggttacc 2618821 acggtccgtc tgaaacaatg aaagcattaa gaaaaaccga acaagaagct ctgcaattta 2618881 tccgcatctc ttttggcagg catacaacag ctgaacagct ggaacagtta ttacatacgt 2618941 ttacagtgct ttgggaacaa aagaaaggag aatttgatat tgaccgaaga attaaagcta 2619001 atgggcgcca acaggcgtga ccagcttctt ctgtggctga aggaatctaa atcaccgctg 2619061 acaggaggag aactcgcaaa aaaagcgaac gtctcaagac aggttattgt acaggatata 2619121 tcgctcttga aagcgaaaaa tgtaccgatt atcgccacaa gccaaggata tgtatacatg 2619181 gatgcagccg ctcagcagca ccagcaggca gaaagaatca tagcatgtct gcacggtcct 2619241 gaacggacag aagaggaact gcagctcatc gtcgacgaag gcgttacagt aaaagacgta 2619301 aaaatcgagc atcccgtata cggagattta actgcagcca tccaagtagg cacccggaaa 2619361 gaagttagcc atttcatcaa aaaaatcaat tctacgaatg ctgcctactt atcacagctg 2619421 accgacggcg tgcacctgca tacactgaca gcacctgatg aacatcgcat cgatcaagcc 2619481 tgccaagccc tcgaagaagc cggcatttta attaaagact aaaaaaagcc ctctagtggg 2619541 ctttttttat aattggtaag actggtatgc acccagaagc ctcactttgc agccgagtgc 2619601 ttcaagctcc tgcatggccc ctggaatcaa tacatcatca aacgctttct caatatcaat 2619661 aataaagaaa taatggccta atccggtttt agtcggacgt gactcaattt ttgacaggtt 2619721 taaatttctc caagaaaatg cagacagcac tctatgcagc gccccggact gatcatcctg 2619781 cggcagcatg accattaagg tcgttttggg cctagagctc aattttgaat tcacttcaaa 2619841 agatatgttt tcatcgggag acaggataac aaatcttgta tgattgtccc tataatcctg 2619901 tatatcccgt ttcacgattt ttaattcgta tgtagaagct gccatatcat tggcaatgac 2619961 cccgatattc agctcgggat ggtcactgac aaactttgct gccgccccgg tagaattggc 2620021 gtattcatat ggaacggaag gaaaatgtcg atgaagaaat ttatggcatt gcgcaatcgc 2620081 gtgtgaatgt gagtaaattt tgtcgagctc tttccatgca ttctctcttg agggatggac 2620141 gagcaagtgc tggtgaatcg gcaacgtcat ttcacccacg attggcaaag gctgttcatg 2620201 tattaaatag tctattgtta gattaacaga tccttctaaa gcattttcca aaggaacaaa 2620261 agcaaaatca acttcgcctg caacggctgc atctatacac tccggaatgg tgcggtaagc 2620321 aacatgttcg gcgccgtttt gaaaacaaga actgactgct agatgtgtaa atgtagctgc 2620381 tggacctaaa taaccgactt tcatgacgat tttctctccc ttatgcacct gaacctaata 2620441 tttcaacctt ttctacaaaa tcaaacttcc tgagcttatt cattaatgta tgaatgtctt 2620501 cttccattgc cgacgtactg atagacagtg tcacatttgc tctgccttga agcggaatgg 2620561 tctggtgaat ggaaagaacg ttgcttccag aatcagctac cgcctgaaga agctgagata 2620621 acgcacctga cctatcctcc aaatgaaaga aaagtgtgat aatttgttct tttaccatgg 2620681 tgtagaatgg aaaaacagca tccctgtatt tataaaacgc acttctactt aaatcgacct 2620741 tttgaacggc atctgctact gaatctgctt tttttcgatc aagcagcttt ttgacttcta 2620801 atgtttttct cattgcatcg ggcaatacat cttcacggac aagataaaat gtctcctctt 2620861 tcatttgcat ccccccttta aaatagagag cctggcacca ggctctcttt tcagccaaca 2620921 ttgattaatc aataaattca aattcaaatt ccagaagcct gattatatct ccatccttgg 2620981 ctccgcgttc tctgagtgct tcatcaacac ccattccgcg catctgtctt gcaaaccgtt 2621041 taaccgattc atcacgtgag aaatcagtca tcttgaataa ccgctcaagg ctgtctcctg 2621101 aaagcacaaa tacaccgtct ggatcgcgtg taatgttaaa tggcacttct tcattttcca 2621161 tcgtgtacat gacacggttt tgtgtaagct cttcctcgtc atacagcggg aattccggtg 2621221 tgttctcaag ctgattggca acctcaaaca gaagctcacg cagaccttct cttgtcaccg 2621281 cactgatcgg gaataccgga taatcatccg tcagcttttc tttaaaggct tcgagatttt 2621341 ccgcagcctc cggcatgtcc attttatttg caacgataat ttgcggacgc tcagtgagac 2621401 gcagattgta ctcgctcagc tcctggttaa tcgtaagata atcatcatat ggatcacggc 2621461 cttctaagcc tgacatgtca atgacatgaa caataaccct cgtccgttca atatggcgca 2621521 aaaactggtg gcccagtccg acgccttggt gtgcgccttc aatcagccct ggcaaatcag 2621581 ccatgacaaa gctgcgtccg tcatccgttt caaccatgcc gagattcggg acaagcgttg 2621641 taaagtgata gtccgcaatt ttcggttttg cagatgagac aacagacagc aaagtagatt 2621701 ttcccacact cgggaacccg acaagtccga catctgcaag cacttttaat tcaagaacaa 2621761 tgtagcgttc ttttcccggc tcgccgtttt ctgaaagctg aggcgcggga ttagccggtg 2621821 tagcaaagcg gctatttcct cttccgcctc ttccgcctct tgcaatgaca gcccgctgtc 2621881 cgtgctctgt taaatcagcg atgacctgtt ttgtatcatc gtctgtcaca acggtgcccg 2621941 gcggaacttt aatgaccata tcatcagcat ttcgcccgtg ctggtttttg gacatgccat 2622001 gctcgccgcg aatcgcttta aagtgttttt tgtatctaaa atccatcagg gtgcggagac 2622061 cttcatctac ttcaaaaacg acgtctcctc cctttcctcc gtcaccgccg gcagggccgc 2622121 ctttcggcac atatttttca cggcgaaacg caaccatacc gttgccgccg tcgccgcctt 2622181 ttacatatac tttgacctga tctacaaaca taatgtcctc cgttctaaac cgttaaaaac 2622241 tccgctagtc caacccaatt tcaatcagac attcgtgact cgtgatttca aaacgcatga 2622301 tatcaacgtc ctcatatcca ttctgccgaa tatcatcaaa agcagatgga tcggcaaagg 2622361 cgccgtgaaa atcaaggtac agaatcagct gtctgtcagg atgatccgtt tgaagcgaaa 2622421 ccgttaaatg attttcactc tctctgctga ctgcttgatc aaacagatga aacagctttc 2622481 tcatcagttt cgccagcttt tgatcataag ccgacaaatc cttaatttct ccgagaactt 2622541 catattcaag cgtcatataa tgggttttcc aattaaacgt aagaaaatca aacgccaaat 2622601 gcggtgtttt caggtttgag agctttgatt cgtgctttgc gtctataacc atttcttcaa 2622661 tcatttcaaa gacacggtca tacttctgta agcttaagtt tcctttaatc agctgcagct 2622721 tattcatcca atcatgccgg gaatggccaa gcagatgaat cagttcgttt gttaatgccg 2622781 tgtcgcttat attttcttct tgattttttg aaacatcctt cattttcgca ctcccaatca 2622841 tttaatttct tatttaggag tctgtataag tgtgtattat gaattataac agagaaggct 2622901 ttgttagaaa aacaattgtt tttcccagaa atatcatgtt ccttttttct ggctttggtt 2622961 gatttgcagc caggcagaac attttatgta ttactgcttg gggaacatat ccagtgggtt 2623021 tgagatgttt attctcattc ttggcggggt ctgctcgcac atactctgca tttcattcta 2623081 ggtgtttact ccgcatattg caaaaaaaac tccagtcatc atcgaccgga gttttttgaa 2623141 tcattattga gctacaggat atacgctcac ttttttgcgg tcacggccga aacgttcgaa 2623201 tttaacagtt ccgtcgattt tcgcaaatag agtgtcatct ccgccgcggc ccacgttttc 2623261 acctgggtaa atttttgttc cgcgttgacg gtaaaggata gaaccgcctg ttacgaattg 2623321 accgtcagca cgtttagcac ctaaacgttt agcctcagag tcacgtccgt tctttgtaga 2623381 acctactcct tttttagaag cgaaaaactg aagatctaat ctaagcatgt agctcacctc 2623441 ctatattatg tttgtggtca cacgcaagtt gtctttgtaa tcccgttcga ttgtctccag 2623501 cgaaacaatc atgccttcaa tcagcagctg agctttttgg cgtgcctctg gatcaagaga 2623561 ttcagggaat tcaaaataaa aataaccccc gtcctctcct atatcaagaa gcggctcgaa 2623621 gcccgcgagc acaatgaccg cgttaacggc cccaaacaca acggctgtca ctccggcaca 2623681 aacaagatct tgtccatgtt cagcaaaatt cgcatggccc gtcatttcaa aagacaatat 2623741 gcctttatca tgagaccttc tgattgttgc ctgaatcatg cttacgcgtt gattttttcg 2623801 atcgtcactt tagtgtaagg ctgacgatga ccttgttttt tatgaacgtt tttctttggt 2623861 ttgtatctga aaacagtgat ttttttcgcg cggccttgtt tttcaacttt agccgttact 2623921 gttgcgcctt caactgtagg gttgccgact ttcacgttgt ctccgccaac aaacaaaacg 2623981 tcttcaaaag taactgtttc acctgcttca gcagcaagtt tttcgatgta aacagtttgg 2624041 ccttcttcaa ctttgatttg tttaccgcct gttttaatga ttgcgtacat tctctgcacc 2624101 tcctattaga ctaagactcg ccagatacca gggggctgta aaagctctta acacctgtac 2624161 tgagcggttg tagcaatggt gctacatcca taacattaaa aaatatacca aaatacaagg 2624221 cgtttgtcaa tcagttttag tagggcagaa gcagttcctc catggaagaa ttcgtccgct 2624281 tatcggcaaa gtaagcgtgc agcacttcat tctcgtcaag ctggctgagc ttttggcctg 2624341 atttttctat aataatcgga tgcttacagc cacgtttgaa ctcggccatc acatgataga 2624401 ctttatcctc cgcctttact gtcagcggca gaagtttctc aagctccctg ttttttccgt 2624461 aatacctttc gaggagaaat ctcacatgga tatagtgcct ttgccgatat tcctcaaaca 2624521 aggaaacagc cagaaagaca aacaaaaccc atgcgctgat ttgcagagga atcacgaata 2624581 aaacccagca cccgagcagc aggcagaagc agagcgacgt ttttagatta agccggtgag 2624641 ccttttgaaa aggcagctgt ttggaaaaca acaaaaataa cagttttcct ccatccagcg 2624701 gccagatcgg cagtaaattg acaaataaga tagaaagatt ataaaaggtg aagagttcaa 2624761 aggtatgctg atgaatcact gagacttctg caagcatcca ggcggcaaac tgaagccaga 2624821 tgtgctgaag aggtccggca ataatgaccg caaactcttc ctttaacggc cgattcccgt 2624881 gctcttccac ttcgaccgtt ccgccaaacg gcagcaaaaa aacacgcttg attctccaag 2624941 aaaaaaacac agccagagca gcatgcccca gctcatgaat caatacaatc aggagcagac 2625001 ataataatgc tttcatatgg cctgtgagca agcccagcgc cgcaataatc caaagaaaag 2625061 gatgcacatg gatctttaag ataaggtcga gccatttatt caaatgaaat cacctgaatc 2625121 ggatcaataa atttatcgcc gtctttcatg gcaaaataat agaccccttt attatgatca 2625181 tcaagcttaa tcgaaccgag ctttttgcct ttatccacaa aatcatataa agcaacatcc 2625241 acatctttga gctcgccata gatactatag gtgttgtcag catgctgcac cttaaccgtc 2625301 agtcccgttt ggctgtcttt gctgacttca accacatagc cttcttttac gctatcaatc 2625361 ttatcactgc ttgtttcgac tttaattcct tccccattgt cctgaaaatc ctgctgtact 2625421 ttcccggatg caggcgcgat cagatctttg cctacttcaa tctgctgttc cttatttttg 2625481 tgttcaggag ccaggaaagc aagcggattt ccgaatttgg tttcgaacca atggcttgct 2625541 gaagcaaatt gaaattcagt ttcaaaggtt ttggctacgg cgggtttaat ctgactgacg 2625601 ggtccaatgt ttgttttata ggctatagct gaaacgagaa caaggcaggc cgacagaaga 2625661 catttcagga taattgaatc tgttttcacc aatgggtgtt ttccgttgaa tgttggcatg 2625721 ttatcttcgt agaccggaag tgttccatgc ttttcctgat ccgttaccat cacccaggac 2625781 gggggtttct gcttttcaga aactgtctga gtagagaaac gttttgagcc ggaaagctgc 2625841 tttcttcttt tctctaatcg ttttctgatt tcatctgctc tgtgactcat tgccatcatc 2625901 ctttgcattc gttgggtttg tacatcatat gtcttgtcca tggcaaatat tcggtttagt 2625961 caagaacaaa gcaggcaaaa acaaaaaaaa cctgacacag catatgcttt gtcagattct 2626021 tctctttgat tctatcacat taagatctta ctccgaaaaa tgacttaatc ttagccatca 2626081 ttcctttgtt ttgctcttca agcacctgta aaggaacaga ttcacctaag atgcggcggg 2626141 caatattgcg atatgcaatg gaagcgcggt ttttagggtc catcgcaatc ggttcgccat 2626201 gattggaagc tttaatgact tcatcatcat cagccacgat tccgagcaaa tcgatcgaca 2626261 gatgctgtac gatttcgtcg atatccatcg tgtcaccgtt tttcatcagg tgatttctga 2626321 ttctgttaac aacgagccgc ggcggttcaa tattttcctc ttgctccagc agtcctataa 2626381 tacggtcagc atcacgaaca gctgagattt caggcgtagt gaccacaatc gctttatcag 2626441 ctccggaaac ggcatttttg tacccttgct cgattccggc aggacagtct atgatgacat 2626501 agtcaaattc ctgtttgagc tcttggacca tgtttttaat ttgttcagga gcaacagctg 2626561 tcttatcgct cgtttgagca gcgggcatta aatagagcag atcatcgaaa cgtttgtctt 2626621 ttacgagcgc ctgatgcatt ttgcatctgc cctctacaac gtctaccaga tcgtaaataa 2626681 ttctattttc aagacccatt acaacatcaa ggttgcgcag tcctatatca gtatctacta 2626741 agcatacgcg cttccctaaa atggctaagg cggtaccgag gttcgcagat gttgttgtct 2626801 tacctactcc gccttttccc gaagttatta cgatagcctc acccaattca cattcctccc 2626861 tcaagccttg ttagatcagg tcttaaatga gccaaatgtt gaaggcgttc aatgaccata 2626921 tttccgtctg tatctaaata agcacattcc atttcgttcc ctttttgaat gtggtctggg 2626981 gagcgattta acacatgatt gattcttaat tgtgtcggaa gcatttcaga ggcggcgatg 2627041 accgcttgat tatttccatt gaatccagca tgcgcaattc ctttcagtga gcccagaaca 2627101 aaaatgttcc ctccggccct gactgttccg ccgggattca cgtcaccgat caggagcaag 2627161 tcgcctttta cctgcagcac ttggcctgaa cggacaattt ttgaaacaga aataatttcg 2627221 gcttcctctc ttatctgctg tgcttctttt ttagtaatga cttcactgtc aatagaatga 2627281 acaaacaaat ctttctttga cgcaatcaat tcggttagct gttcctcttg ctccttatat 2627341 aaaaagcgat ttcccagctt aacatgaacg ctgattttct ggccttttcc atcggtatat 2627401 tgttcaattg acagcatatt ctgaagacca tcgagaagct catcaaaaga acacgcatca 2627461 tccagatgca atgttagtcc attctttgtt ccttttattg ttacatattg ctgctttttg 2627521 gtcttcacaa tattcacctc aacaacatac tcatttcgtc aaaaaaagat aaaatccttt 2627581 ttactcatct ctcaattctt tctttagact cataaaaaac aatctaaatg gcagaacaag 2627641 aataagagct gctgcaatat ttaataaaat tgtcggtata aaccggtcaa gcacaaatcc 2627701 gttaaacgtc ataatgtctt tatgaatcaa agactgaatg ccgaatacgt aaaattcgag 2627761 cagacagaca gccagaactg ctatcaatat cactacaaat gcgtttgtat gcaacacttt 2627821 aaacgctttt gaagccaaat agcatagccc tgcaaaacca aacatgtaaa cgcctaatag 2627881 acttgtatag ttcatgtcat atagaaagcc aaaaataaat ccgtaaatca tcgcgtgttt 2627941 ttggttgata aaagccgaca tgaatatcaa tacaagcatc aaaaaacgcg gggcgagcac 2628001 ttggtcatct gtaacgaaag gaaaatgcac caaatctgta aaaatgcttt ccgcagaaaa 2628061 aacaagcatc ataacgaaag ggagaaggaa acgtttcacg atccttcctc ctctgtatcg 2628121 acagtcggca cgtcacggtt aacaacgatc acattattta aatctgtaag gtcagccgca 2628181 ggttttacat aagcaacctt cgttaatcca taggaatctg actcgatatc agtcacttca 2628241 ccgattgtca gcccttctgg gaaaacaccg cctgtccctg atgtttcaat aagatcgcct 2628301 tttttcacgt cttgtttatc cttacgctca ataattgtca tcttaagacg ttttttctct 2628361 ttgtcatatc cttcgatcaa gccgtagcct ttgctgcctt tttttccgga aatttttgtc 2628421 gcgactctgt tattgcggtc agtatcgctt aaaagctgaa cagcagacgt aaaattgtta 2628481 agtccggagc ttttgatctt gccgattaat gcgccttttt cgtttgtaac ggccatatct 2628541 ttcgctacgt tttgctgagt ccccttgtta atggtgacct gtttcgccca attatcaggg 2628601 cttctggcga tgaccgttgc taaaatcggc ttgtaatctt taatcgattt gacatggcca 2628661 agctcgtcac gcaaggattt gttttcttct tcaagctctt gaagcttggc ttcatattgt 2628721 gtctgtccgt caagtttttc tcttagacgc tcgttttctt tgtatgtgtt ttttaaatca 2628781 ttgatgttct caaatattcc tgcaaaaaat tcggcaggcg tatgaaaaat attttgaaat 2628841 actcccgtcg tatcgccgat cactttctca ggccaggtgg tattgcggcc gcccttcagc 2628901 gaaaatccaa tcatagccac caatatgata atacacagaa gtaatagcat taaccgctta 2628961 ttcggcatcg tgttacacct cttctattga actcccgatt atctagtttt ccctttgaaa 2629021 agatggatgt gctccagtgc tttccctgtt ccgatcgcta cacaatcaag cggatcttcg 2629081 gcgataagga ccggcatttt tgtttcttcg ctgatgactt tgtccaaatt gcgcaaaagc 2629141 gctccgccgc cggttaacac tatacctctg tccatgatat ctgctgcaag ctcaggcggt 2629201 gttttttcga gtgtgctctt cactgcttcg acaattgtag atacagtgtc gcgtagagcg 2629261 ttagaaatct cttttcctgt aatttcaatt gttttcggca aacctgtgag caaatcgcgg 2629321 ccgcggattt ccatgttgtc ggattcttca ggagcttctg cagatccgat ttccatttta 2629381 atcgcttcag ccgtacggtc accgatcatc agattgtacg tttttctgat gtagttgata 2629441 atcgcgtcat ccatctcatc accggctaca cggattgact gagacgttac gatgcctccg 2629501 agggaaataa tcgcaacttc tgtcgtaccg cccccgatat caacaaccat gcttccagtc 2629561 ggttcccaaa ctggcagatt ggctccgatt gctgcggcaa aaggctcttc aatcggatac 2629621 gcgtcacgcg ctcccgcctg tcttgtcgca tcgataacag cgcgttcttc aacagctgta 2629681 atgcctgatg ggacacatac cattacatat ggttttctgg caaacatgcc tttatttttt 2629741 atggcctgat tgatgtaata tttcatcatc gtcgccgttg tttcataatc agcgataacg 2629801 ccgtctttca tcgggcgaag agccaccacg ttgcccggtg tccgtccaat catatttttc 2629861 gcatcatttc cgacagcgac aatcgatttc gtatccgtct gcaaagcgac aactgacggc 2629921 tctctcacaa caattccttt tccttttaca aaaacaagcg tattcgcagt tccaagatct 2629981 ataccaaggt ctctagcacc aattccaaac atatgtatgt atcttccttt cttaaagcaa 2630041 aaatacccta aagggaaaaa ctcataaact ctattatagc ttaattcgac gaaaaaaaaa 2630101 gtgttacaaa tatccttttt cctttaaact cacaaatttt ttatccccga tcaccaaatg 2630161 gtcaagcagc tcgatgccaa tcaggtttcc gcattcaaac agccgtcttg tcacttcaat 2630221 atcttccctg ctcggcgtcg gatctccaga aggatgatta tgaacacaga taaaggaagc 2630281 ggcagatcgt ttaaacgctt ctttaaacac ctctcgcggg tggacaatag atgaattcag 2630341 gcttccgata aatacggtgc gtttatggat gacttgattt tttgtattta agtataaaca 2630401 gacaaaatgc tcctgggtta aaaagcgcat atcctccatg acaagattag cgccgtcttc 2630461 cggggagcga ataacgaaat gttcttcgtt ggctaattta tgaatccggc ttccaagctc 2630521 aactgctgcc agtatttgaa tcgcttttac cataccgatt cccgggatgc ttgacagctc 2630581 ttcaaccgat gcttccttga gcaggcgcag cccgtcaaat gagcgcagca gccggtttga 2630641 caggtccaaa acagattcgt gtttagtccc tgtccgcaat aatatagcca aaagttcatg 2630701 attcgctaag ttctcggctc cgactttcag gagccgttcc cttggctttt ctttcattgg 2630761 gaaatctttg agttttaatg gcagatcgtg tatgaccaag cactcctttt ctttcccttc 2630821 ccgtttatag aaccgtcatg cccttatatc aaaatggcga agagctctca ttgtttttga 2630881 tataggaagg cccatgactg aataataatc tccgtctatt ttctttacaa aaagcgcgcc 2630941 tcttccttgg atgccgtatg cacctgcttt atccatcggc tcttttgttt caatatatgt 2631001 ccaaatctct tcttcactga gggaccaaaa cgcaacttct gtcttatcat aaaaagtctc 2631061 gctgtgattt tcagcttgaa tgctgaccgc ggttattact gagtgacttc ggcctgaaag 2631121 cctccgcagc atagaagcag cttcttcttg atcctgcggt ttgccaagac attcgccgtc 2631181 aaggcatacc attgtatcag caccgataac gattgcatgc gggtggagat cagctacagc 2631241 cttagctttt tgttttgcca accattggac gttttcttct ggtgaaaagt ttcgatttaa 2631301 tttttcttct acttcactga caataatgga gtagggcagc tggagaagat cgaggagttc 2631361 tttcctgcgc ggagattgtg atgcaagtat tagcggtttt gtcatgttcg tcatcctttc 2631421 agggtttgct taagaaaaaa agatactcgt ttatcctacc aaatcacgag gcttgtcaca 2631481 atttcagaaa aataactttt tcatgacaaa ataaaaaaag cctgtcacta aaggacgaag 2631541 gctcagggca ctatctctta ttttacgacg gctaacagct cctgctgagc cttccacccg 2631601 gcttcagcac ttggatcctc taattccttt aaagcctgca aaatcgcttt tttctctcct 2631661 gtttctgacg cttttgtttc accaagcgac ttttctattt tctctacact cgcttttgta 2631721 atgtcttcgt cgagaatcgc ctttgctgca agctccgctg tttccttaaa agaatctgtc 2631781 atatctgact ctattgataa ggaaagctcc ttgcctcccc aggcttcaaa atcactgtcg 2631841 attaaaacct gtcctaactg ctgtgagacc tccttttcac ttgctaagcc tgcaataaca 2631901 tacgtatacc cgtcatcctt tgacagtgac acggcggaat atcctttttc ggtcaattgt 2631961 tctgttaacg tttcggcgcc cttttcattt gaaaattttc cggcttgcac agcgtatgtt 2632021 ttgtatgtac cttcagtttg tgccgcttgt ttttctgcgc ctgaggtttg tttatcagca 2632081 gaagtatccc ctgcttttgc cgtttggctg cctaaagaat cctctaaaga ggccggtgct 2632141 gacgcttctt tattccccga tatgtttaac gcgaataacc ctaatccagt gccaatgaca 2632201 gccgcgaagg caatcgtcgc ggccactctt tttaccggtt tggcagcccc ggtctttcct 2632261 tttgcgtaaa gctttgtttt tttcttttga aaaggaggaa caactttagg gtcctcttta 2632321 aacaccttgt cctcctcgga atcccaattg aattcatctt catcagggtg ttcctgggat 2632381 gccgcaacct cttgttctgc ctgtcttttt tcctcccaat ttgaaaatgt catgctttta 2632441 ttcgcctctg tctcaggcgt ctcttgttcg taaaccgtct cttcttttcc attaatcgtc 2632501 accttgaggg ctttttctgc ggctttactg ttttttttat tctttctttt tttcaattcc 2632561 gcttcctccc ttcatttgct tgaccgttct tgtcggcttt tcatgctaca cactttagca 2632621 caggcaaaga aaaaaagaac aagacttttg tcgccttgtc caaaaaacgt tcgtcaaatt 2632681 tttcagcagt cagcccaatg ccattttgat ataaaaagaa atgatagagt caccgtataa 2632741 ataggctaaa atgctccctg cggctatagc gggggcgaag ggaagcggct gccttttagc 2632801 gagtctacca gtcagaacag ctgccgctcc atataatgca cctatcaaaa ctgaaaagaa 2632861 aaaggcagct gccagcattt tcacaccaag cacaaagcca atcaccgcaa ataatttaat 2632921 atctcctccc cctactcccc catgggtgat tgcggcaatt acagccagaa acaaaaatcc 2632981 ggctgccgca cctaacaggc ctgcatacca ggaatcaagc ggagaaatca atctcgcggc 2633041 cgccaaaaag ggaagaaaga aaatcaatat tcgatttgga atcagcataa aatgaatatc 2633101 tgtcactgca acaataatga gaagagagat aaacaccaca gcgggaaaca gttccagcga 2633161 tatgccaaag cgtattcctg cggcggcaaa taaacacgct gtcacaagct ctgctgcggg 2633221 atacataaaa gaaatcctat gcccgcagct tttacattta cctttttgaa ataggaatga 2633281 caggatggga attaattctg caggagttaa tgttcgccgg caaaacgggc atgatgaacg 2633341 gggcgcaata atagatagat gtaaggggat acggcacccg gccgtatagt aaaaagaacc 2633401 aaggataagc ccgaagataa aaagaatgga tagcatagac aacacacctt tactcattga 2633461 gttctggtat ggattgtagc aaaatggaca tcctgagctc caattgggaa tattcaattt 2633521 tacacatgaa aaaaacggca gaatcttttt ttgattctgc cggagccgga tgcttttatt 2633581 tcaacctttt tcgaatgtca gaaataaagt aaagagatcc ggtaatcagc acaatttcat 2633641 ttgagccctt tttactttct atgaatttga ttacatcgtc tggatcttca ctccagcttt 2633701 tattgctgat ttcacttgca tcatagagat cttttgcaag ggaagcacgc gggaaatcaa 2633761 aagaagcaaa atgaatcgca tgagcaatgg tttccagtct tttaatcatg ttctgatacg 2633821 gtttgtcctt taacgcgcta aacaccacag aaatgcgtga attggcgaaa cgctgcttca 2633881 tcgtttccgc cagcttttca acaccttctt cgttatgcgc accgtctaaa tataccggag 2633941 gatgttcctg aacaagctct aaccgtcccg gccaagcagc cttcacaagc ccgctcctta 2634001 acgcttcgtc actgatatgg gcgatattct ccttattgag ccactccgca gccaaaatgg 2634061 acaaagcagc attttgtctt tgatgggtgc caatcagaga tgtccgaata tcttcatagc 2634121 atttctcttc cgttttgaat gaaaactgtt ctcctgcagg cagagcctct tcattgaaaa 2634181 taacacatgc atcatgcaat gactggaacg gcgcagcatg ccgttcggct tcatggcgga 2634241 tgacctgtaa agcttccggc tgggtaactg ctgtaacgat tggaatacct tctttaataa 2634301 tgccggcctt ttctcctgca atttcttcaa tggtgtttcc caaaatgttc atatgatcgt 2634361 gtccgatgct tgtaatcaca gttaagagcg gttcaaccac attagtagaa tcgaatctac 2634421 cgcccagacc tgtttcaaaa ataacaaaat cgaccttatg aaactctgca aaatataaaa 2634481 atgcacaagc tgtcataatt tcaaattctg tcggctgtcc gtattccgtt tgatcaaggg 2634541 cttcaacgtg cggtttcatt tgattgacga gtgctgtcca ttcctcatct gaaatcggta 2634601 tcccgtttac gctgatccgt tcattaaacg taataatata aggcgatgta aatgttccaa 2634661 ccgtatatcc ggcttcctgc agcatagaac ggataaaagc gacagttgat cctttaccgt 2634721 ttgttcctgc gacgtggaac gctcggattt ttttttcagg atgtcctaac cgcgccatca 2634781 gctgtttcat tcgaccaagt ccgggcttca ccccgaattt cagcctcccg tgaatccagc 2634841 tgcgcgcatc ttgatatgca gtaaacaatg ataatcccct cttttataag acaaggcggt 2634901 ttctctagaa accgccccgg cttttcatta acccttcagc tcagccattc gtttttgaac 2634961 agcgtcacgc ttcgccacat aatctttttc tttttcacgt tcttcatcaa ttacgtgtgc 2635021 aggcgctttt ttcataaatc cttcatttcc aagtttcttt tggacacgct caacttcttt 2635081 tgtcagttta tcaaattctt tttgcagacg ggcaatttct tcatcaatat tgattaagcc 2635141 ttcaagcgga agaataacct ctgctcctga gacaacggcc gtcatcgcct tatcaacagc 2635201 ctcaatatcg gtgccgattt taagcacgct cggattcgta aagcgttcaa catatgaacg 2635261 gttcgcttcg aggcgggacg ctatttcgtc tgtgcttgtt ttaatgtaca gttcaacctg 2635321 cttgctcatt ggcgtattga cttcactgcg gatattgcgc acagaacgga tcagctcaac 2635381 aagaagcttc atgtcagctg ccgcttcagt atcggtatgc tccggcacta ctgcaggcca 2635441 ttgacttact gtaatcgatt ccccttggtg aggaaggtgc tgccaaattt cctccgttaa 2635501 gaatggcata aacggatgga gcagacgcat cgtttgatca agtacgtaag caaggatgga 2635561 acgggtagtt ttcttagccg cttcgtcttc tccataaagc ggaagcttcg ccatttcaat 2635621 ataccaatca cagaaatcat cccaaataaa gttatataaa tggcgtccta cttcaccaaa 2635681 ttcatatcgg tcagcaagct gggtcacgtg ctcgatcgtt tcatttaatc gcgttaaaat 2635741 ccacttgtca gcgactgact tttcacctga cagatcaagc tcatcgtacg tcatgccatc 2635801 catattcatt aatgcaaaac gggaggcgtt ccaaatttta ttggcaaaat tccaggtcga 2635861 ttccactttt tcatagctga agcgcagatc ctggccagga gagcttccag tcgcaaggaa 2635921 ataacgcaga gaatcggctc cgtacttgtc aatcacatcc atcgggtcga caccgttgcc 2635981 aagagattta ctcattttcc ggccttgctc gtcacggatt aagccgtgga ttaaaacatc 2636041 tttgaacggg cgctcgcctg taaattcaat gccttggaaa atcatgcgtg atacccagaa 2636101 gaaaatgata tcgtaccctg tcacgagaac atctgtcgga tagtagcgtt taaagtcttc 2636161 agccgttaca tcaggccagc ccattgtgga gaaaggccat agcgcagaac tgaaccatgt 2636221 atccagtacg tctgtatcct gttcccaatt ttcgctgtct tccggcgctt caagtccgac 2636281 atatagctcg cctgtttctt tatgatacca ggcaggaata cgatggcccc accacaattg 2636341 acgggagata caccagtcgc ggatattttc catccagtgt aaatacgttt tttcgaaacg 2636401 gtcaggcaca aagttgacct tttcttcttt tttttgcagc tcaatcgctg catcagcaag 2636461 cggctgcatg cgcacaaacc attgtgtaga aagataaggc tccacaacag ccccgcttcg 2636521 ttcactatgg ccgacagagt gcatatgatc ctcgatcttg aagagaactc ccgcctcctg 2636581 taaatctttc acgagctttt tgcggcattc aaaacgatcc ataccttgat attggagcgc 2636641 attttcattc atcgtgccat cttcattcat gacaaggatg cgttctaaat tgtggcggtt 2636701 gccaagctcg aagtcgttcg gatcatgagc aggcgtaatt ttcacggcac ctgaaccaaa 2636761 ttccatatca acatagtcat caccgacaat cggaatttca cgatttacaa tcggcaggat 2636821 caccgttttt ccgataaggt gtttatagcg ctcgtcttca gggtgaacgg caacagctgt 2636881 atcaccgagc attgtttcag gacgtgtcgt cgcaatttca attgagcctg aaccgtcagc 2636941 aagcggatag ctcatatgat agaatgcgcc ttgaacatcc ttgtaaatca cctcaatgtc 2637001 ggatagggct gtttttgtcg ctgggtccca gttaataata tattcgcctc tgtagatcag 2637061 gcctttttca taaagcttaa cgaatacttc ccttaccgct ttgctcaagc cttcatccag 2637121 cgtaaaacgt tcacgggaat aatctaggcc aagacctaat ttcgcccact ggctgcgaat 2637181 aaagtcagca tattcttcct tccacttcca cgtttcttcg aggaattttt cacggcctaa 2637241 atcgtagcgg gatttgcctt cttcacgaag tttcgcctcc actttagcct gtgtcgcgat 2637301 gccggcgtgg tccatgccag gaagccacag cacatcatag ccctgcatgc gtttcattct 2637361 tgttacaatg tcttgcagcg ttgtgtccca tgcgtggcca aggtgaagtc tccctgttac 2637421 gtttggcggc gggatgacaa cagagtatgg ctcttttgtc tggtcactgc ccgcttcaaa 2637481 aaatttgcct tttagccaaa aatcatatcg gtctttttca accgctgccg gatcatattt 2637541 cgtcggcatt gtttgttcat tcgtttccat cataaccctc cagcatgttt aaaaatggct 2637601 gagaacgaaa aaagagctct tcatccctgt aaaaggacga aaagctcttt cgcggtacca 2637661 ccttttttca tgaactcaat cagttcatgc acttataacg gataacgggt gtttcccgaa 2637721 tttctctact cttctttcaa gaaattatgc tcccgggcga ccttccaatc agacaacata 2637781 agaagccttt cagcaaacgg cttctctctc tgcatgcgcc ttttttgtac tcttcccgtt 2637841 ctaagcaggt gtatttatca gctcattgta tacattattt atgttcttta ttatagtaaa 2637901 agtgtttttg attcgtcaat catcttttcc aaaaacaccg ctttctatac agatgggcag 2637961 gcacctattg cccaagttta catatgatgc ttgtaaatgc gtagaggagg atgcaccgtg 2638021 aagaaacgtt tcagctctta ttcgctgccg ccatgggtaa ggcaaattcg gcttgtatcc 2638081 gcacaagtga ttattcccat tacgattttt caaggaatca gaaccatttt ctttccgaca 2638141 acctttgatg ttttgctgct cgcaatccta atctttttag cttgcgccct tcatttagaa 2638201 tggatataaa caaacaagtc cgcgccatta agacgtggac tcgttttcag cctgaaattt 2638261 tttctcttgt tcaatctgat gaattttcat cacaaacggc tctatgtttt tcatttgcca 2638321 ataagccttt aataattgtg tacattcctc tttttcatgc tgtcttttcc cagtttgata 2638381 accgttcagc accttgtaca tggctgccgg atatgccata tagctgagaa aaaggctgac 2638441 ttccgcttca cgcaaaggga atgatttcgt atatccataa aaccattcga cgcattccgg 2638501 acaagctttc ggaaagcctc tgaacatttt tgtataaaag ccgagcaggt cgttttgcgg 2638561 cggaccgaca gatgctcttt cgaagtttgt aaaatatccg gtcccggcat cattatacag 2638621 aaaatggtgt atagacaggc tgccgtggtt cattacaacc cttgaaacgt ccttttcctt 2638681 tgcggactca taccagtcct ccagccgttc cagcgcaaag ttcaccgcgg aaatggtttc 2638741 agaaaaatag gttatggcct ggagttcaaa gggagaaagg taccattcct tctccgctct 2638801 atccacaaac tgctcataga aaattttatc ttgttcccac ttttttttcg tttgcccgta 2638861 ataacgttca atctcatcac gtctaacctt tagttcctgc gcggttctct cgtgaagacg 2638921 ggctgtttct ctaaataaat aagcatgttt ttgatcccgt tcttcctctt ggtcaaattg 2638981 gagccaaggc attaaatagt agatatctcc gtattgtatg cctgctgaga aaaactcacc 2639041 gctatttgtt ctgtaaacgg gaacgaatga acgaaagcct ttttcctcaa tcgccaccat 2639101 atgatctgta aaatgcttgc cgcgaccttc tttcaatttt ttcagggcaa atatgccgta 2639161 gtctgtatac actttccaaa caagaggact gacaggctca ataaattgag cagtcagtcc 2639221 gtattcctga agaaccgatt gggtatcttc catttcattc accacatttt ccgatcactt 2639281 acggtttacg catggctatt tttatattga ggaatataga gaatctgtcc tgcttttaat 2639341 tcatcatcca aggctaaaga attcatcctg atcagctgct gggatgtaat ttcataccgt 2639401 tcgcataaac gctcgatcgt atcttcctgc tgcacaatac aaattttcat tctcgaaaac 2639461 tcatccgctt cttttgtaaa gagttttgtt aaataaagag aattatcact ttcctttgtt 2639521 tgaggttcct tcgtttcagc agcaggagca accctaggaa cagcatccgt ttccttcctt 2639581 tcagtctcag aagattcagg cagctggaag gattgaaaag gtgtttcttc cttaggctct 2639641 tcagctgatg gtgtttttct cacttcaatt tcgaagctct cttcctcttg ttcttcctcc 2639701 tccagcagct taggcgctga ataaaaagaa tcctcctctt cttgttcagg caggaaggta 2639761 cggtatgccg gttcaggcaa ttcttcttga gatgcctcct ccgagcttgt tttttgattg 2639821 aaatggaaat gtaaatcggc attgtcattc tccatatata cagctgaagc tgtttctctg 2639881 ctatcttcta tggagagagc ggcctctgat acactctcca aagcttcatc cggttccgcc 2639941 tcttcttggc aaagcgcagg atcagcctga tccgattgag ctgcttcttc attttgagcc 2640001 tcttggcgca gcgcatattc atgattagga gacactgttg tttcctcttt ttcctttgca 2640061 atcacagtct ctgaatgaag ctcagcttcc aaagcaggcg attcttctgc tccaacgtgt 2640121 tcacgaagct cagtctccgc tggagagtct gcttcttcac gaacatccgc tattgcagct 2640181 gccggctctg ccgtttcttt ttttgcttta acgatctctt gaatctctat ttctgaagga 2640241 tcaggttctg gctcagattc ttctgtttcc gattcagcac gaacctccgt ttccggcaca 2640301 gcaagctctt ctgactcttc ttcctctttc acatcttctc tggcctctgg ttctgaagca 2640361 accgattcag gcggctcaga ttctgctttt tctgtctcca gttcttcacg gagccccgct 2640421 ttcgagataa aaagttctgg cggttcggct ggcggttcat gctgaagaac tgcttcctct 2640481 gccgatgatg cacccggttc ttctactaca ctatgtgccg gcggctctga aagctcttcc 2640541 tccctgaatg ccgcaggagc ttcatataaa ggtatctccg gctctttgtc ttgcgtatcg 2640601 tccaaaagcc cttcgatcgc taaatcagct tgaattgtta aaatgcgcga atccgtcaat 2640661 tgatagtcaa atgcgtcaat aaagacgaag acatcctgta aatggctcac tttatttttc 2640721 ggaatggtaa tatccacagg aaaacagtga gtcagttccg cacttccatc ctctctcttt 2640781 ctgacttgtt caacaaaccg cttatctgta taaatctctt cggtatgttt gttttgatct 2640841 atgttgtact cacctgtaag ttcaagcgat cctatgattg atacataatc atttacttcc 2640901 tgaaccctaa tatcaggatc taatgaaata gaaagcagtt cagaaacttc ctgtcctttt 2640961 tggaaacaga tcgattcttc tacagaaaat tgcaatcgat gattttgcgg caagttcata 2641021 tcctcctttc atctaatcct taaaattaga tgtcactaaa ggtgtatgta tgaactggag 2641081 aaaatatgag tgggagagca cgaaaaaacc ggcacaagga gtccttgata ccggttttca 2641141 ctcttatctg cggctgatct cagcaaatac tttctcagct gcctggattg tgttttcaat 2641201 atcttcatca gtatgggccg ttgagaggaa aagaccttcg aattgtgatg gcggaaggaa 2641261 taccccttca tttgccatcc ctttataata gcttgcgaac agcttcaaat cagatgattt 2641321 cgctgtttca taattgatga ctggttcgtt tgtaaagaag aaaccgatca tcgaacctgc 2641381 acggttaaag gtatgcggaa tgccatgagc cccggcggtt tttgaaattc cttcttccag 2641441 tctgtcgcct tttttgatga aattcttgta ggattcaggt gtcagctgtt tcaatgtctc 2641501 taagccagcc gtcatcgcaa gcgggttgcc tgacaatgta ccagcttgat agatcggacc 2641561 gcttggagcg atctgctcca tgatttctgc ctttccgcca taagcgccga caggaagtcc 2641621 gcccccgatt acttttccta aacaagtcag atcaggcgtt acgccgaagt agccttgagc 2641681 gcagttataa tcgacccgga agccagtcat cacttcatca aaaatcagca gggagccgta 2641741 ctgctcagtg atatcacgca gaccctgaag gaaaccttct tgcggcggaa caacacccat 2641801 atttccggca actggctcta caatgactcc cgcaatgtct tcaccgaatt gctggaaagc 2641861 aagctttaca ctttctaaat cattgtacgg aacggtgatg gtgtttttcg caatgccttc 2641921 aggcaccccc gggctgtcag gcagaccgag agtggcaaca cctgaaccag ctttaatcaa 2641981 gagagaatcg ccgtgtccgt ggtagcagcc ctcaaatttt aaaatcttgt tgcggcccgt 2642041 atagcccctt gccaaacgga gggcactcat tgtagcctct gttccggagc ttaccattcg 2642101 tacaatttct acagatggca cacgatcaat gacgagctta gccagttcat tttctacttc 2642161 agtcggagca ccaaagcttg tcccgtattc agccactttt ttgaggcttt ctacgacgcg 2642221 gtcatttgta tgccctaaaa ttaaaggccc ccatgacaag acgtagtcaa tatattcatt 2642281 cccgtcaata tcaaagattt tcgagccttt tccgcgctcc ataaaaatcg ggtccatgtc 2642341 taccgattta aatgcgcgaa cgggactgtt cacaccgccc ggcatgagtt tttgcgcttc 2642401 tttaaaagcc gtttttgatt tttcatagct tctcatctgc ctcaactcct gtcaactgaa 2642461 taaaattact ccgcaagcca tttcgctgcg tctttcgcat gatacgtaat aatcaggtcg 2642521 gcacccgcgc gcttcatgct tgtcaaaatt tccaacacaa tttctttttc tttgatccag 2642581 ccgttctgcg ctgcagcctt caccattgaa tactctccgc ttacattata agcgacgagc 2642641 ggcaaagtaa actcattttt tacgtcacgc atgatatcca tataagaaag cgaaggtttg 2642701 acaatcaaaa agtccgcgcc ttcctcaaca tctgattgtg cttcgcggag tgcctccata 2642761 cggttggcag ggtccatctg atatgttttg cggtctccga attgcggtgt gctgtttgct 2642821 gcatcacgga acggaccgta aaactcactt gaatatttaa cagcgtaaga catgatggga 2642881 atattgacga atccttcttt atcaagtgct tctctgatca ctgtaacaaa tccgtccatc 2642941 atgtttgatg gcgcaatgat atccgcacct gctttcgctt ggctgacagc tgtctgcgcc 2643001 aaaagctcca gcgattcatc attgagaatg actccgtctt tgacaagtcc gcaatggccg 2643061 tggtctgtat attcgcacag gcacgtgtca gcgacaacaa ccatttcagg gaagtgttct 2643121 ttaatttctg tgatggcttt ttggacaatt ccgtgatcat ggtacgcttg tgttccgcaa 2643181 tcatcttttt cttccgggat gccgaacacg ataacagatt gaatgcccag tttgaccagc 2643241 tccgctactt catccttcaa taaatctaat gatacatggt gaacatcagg cattgacgga 2643301 acagcttttt tgccttccag cccttcaacg acaaaaatcg gatatataaa atctgatgga 2643361 tgcaaacgtg tttcctttac catttctctc attgcttttg atgtccgcag gcggcggtgt 2643421 ctattaaatg attgactcat attctctctt cctctcttga catgctgcac attaactcaa 2643481 gcatgccatc tattgtaaat gtatcaggcg tatgcgatgt gatgccgtac gtcagaaggg 2643541 catcatttgt taaaggccca atgctgatac aggccgtccc attcgccttc cactttttta 2643601 attcttctcc caagacatgc ataaacgtat gtacggttga tgaactcgta aatgttacat 2643661 agtcaaagga atattgaccc gcagcgtctt tcaatgcctc aatgccttct tcatccggaa 2643721 tcgtttcgta gagaacccat tcctttactt caaaaccgag cgggacaagc tcttgtttta 2643781 tcacatcacg tgacaaattc cctttcatca cggtaatggt ctcccccggt tcagcatgct 2643841 gcttaagagc gtcagccaat tgttcagcaa tatactcctg tggcatcaca tcaaccgata 2643901 cgttatgcat ttttaaacgg cgcgcggttt tttcaccgac ggctgcaatt tttttatgcg 2643961 cagggagaat aagctgattt tccttcagat aagaaaaaaa gaagtctgcc ccgttcacac 2644021 ttgtaaaaac aagccagcct ggcgcggcaa gatcctctct tacctgttcc gcaacatcat 2644081 tcggcaaagc gcggcgaaac gtaatcaaag aggttaaaac cgctttaccg ccaagcgcct 2644141 ccactttttg ctgaaatgat gctgcctgtg ccttattccg ggtgacaagc actgtttttc 2644201 ctttcaacgg aaaatcattt tccatcctcg tcaagctccc gttttacacg atcaattaaa 2644261 tcttttgctc ctttgtcagc cataagagcg gcacagcgct ttcctacttc ctccggatcg 2644321 tttccggtga cggtttcttt aaaaatgatt ttgccgtcag gtgaagcgac aagacctgtc 2644381 atttcaattt catcctgtcc atttaacacg gagtagcccg cgatcggaac ctggcagccg 2644441 ccctccatcg cgtttaaaaa agcacgttcc gctaagacag tccgttttgt atattcatct 2644501 gtaaactgag aaaacaacgc caacagctct tcatccgatt ctcggcactc aatcgccagg 2644561 gctccctgcc ccacagcagg caaacagcgc tcaggctcaa ggaattcggt tacgacatct 2644621 tgcttccaac ccattctgga aaggccggca gccgctaaaa taattgcgtc ataatcctct 2644681 gtttccagct tttgaagtct tgtatctata ttacctctaa tccatttaat tgtaaggtca 2644741 gggcgctcaa tcaaaagctg cgcgcttctt cttaaactgc ttgtgccaat gacagcacct 2644801 ttcttcattt ctgaaagctt tacgcgattc tttgaaataa gggcatcacg cgggtcctcc 2644861 cgttcaggaa tacagccgat cacaaggcct tcaggcaaaa cagcaggcat gtccttcatg 2644921 ctgtgcactg ccatatcaat ctcttcgttt aaaagcgcct gttcaatttc tttgacaaaa 2644981 agcccttttc cacccacttt tgagagtgta acatcgacaa tccggtcgcc ctttgtcacg 2645041 atctctttaa tttcaaaagc aaacgaagga ttgatttcct tcagtttttg aataacccat 2645101 tttgtttgag tcatagcgag tttgctccgt ctggaaccta ctttaatcgt tctcatcatt 2645161 tctttcctcc cgaatctgct tgggacatcg tttaactgaa ccaatggaat tgcgacaggc 2645221 ttccaagcag gaaataattg atcatcagca ccagaaaaca agccgtattc cacagtgcag 2645281 cgacctttcc ttgcagctcc ttaatcagcc tgatataaag ataatagctg tacagcagca 2645341 ggacgacaaa cgaaccaagc actttggcgt caaaccaata cagcgtttct agtgagacat 2645401 acgcccaaat gacgccgaga atcaaactca gcagcagcat cggaacccca atgacattta 2645461 aaacatacgc catataatca agcttagata aatcttctat tctcaacagc cattttcccc 2645521 actttttctt tttcagcaga tgatattgaa acatatatag cacagaaaaa acgaaagaaa 2645581 gggaaaaagc gccgtatgaa agaatcgcca ttgtaatatg aatcaccaaa agctcggata 2645641 caagctgccc ggaaaaagca gctgactgct gctctgtcgg tgaaaatgtg tgaatggcga 2645701 tcatagaaaa tcctataaca tttgtaaaaa acacgataaa gtcaacacgt aaaagctttg 2645761 tcagtacaag tgacagcgtg acaagcaccc aggcataaaa ataaagtgcc tctgtcacat 2645821 ttaataccgg aaaccgcccc gtcacccaca taaaataggc caaatacacg gtttgcagag 2645881 tccagacaat agaaagcaac cagaaggcca tttttccagc cttccggttg tgttgaagaa 2645941 aatctataaa ataaaagagt acacttaacg cgtaaatgac gattgtcccc tcattaagtc 2646001 ttgccattgc agtatcaatc attcagcttt cactcactta caagtgggct aaagcccgct 2646061 tttgattcag ccttcttaaa agagtggacc ttctggctgc tttcaacggt tttcatcatt 2646121 tgacggcccg cagcttcttc aatatcaaaa atctgcataa acaacgcgag cttttcttca 2646181 gaatcagcat ctgccgcaag ctctttcacc tttaaaatcg gatcacgaag catttggtta 2646241 ataatacttt tggtgtgttt gttcaacagt tttttctctc ttgtgcttaa gtgaggcagc 2646301 ttacgctcaa tgctgtccat cgtttctgac tggatggcaa gcgccttttc gcgcaatgca 2646361 gaaataacag gcacaacacc aagtgtattc atccattgtt taaattccac aatggtttct 2646421 tcaattaaca gttcaacttt ttcagctgtt tctctccgct ctttcatgtt cgcttctaca 2646481 atgccttcca gatcgtcgat atcataaaga aaaacacctt caagatcatt cagcgccgga 2646541 tcaagatctc taggcacggc aatgtcgacc ataaacagcg gacgtccctt gcgaagctta 2646601 ttcgcgtttt ccatcatctc tttggacacg acaaattcac ttgcaccggt tgaactgatt 2646661 aaaatatcag cctccgcaag cgcgctttca agctgattca agcttctcgc ttcacctgaa 2646721 aaacggtctg caagctcctt cgctttcaag tatgttcggt taatgacagt gaccttgccg 2646781 attccctgtc cgtgcaggtt ttccgcagca agctcgccca tttttcccgc accgagaatc 2646841 aatatgtgct tgcttgaaag atttccgaag atttttttgg caagttcaac tgcagcatag 2646901 cttactgaca ccgcatttga gccaatgtct gtttcggcgt gagtccgttt gcccactgta 2646961 actgcctgct taaacagctc attaaaaata gtcccgatcg ttttttcttg ctgagctgtt 2647021 ttaaagctgt cgcgtacctg tccgagaatc tgcgtttcgc caatcaccat agaatcaagt 2647081 ccgcaggcta cacggaataa atgctcaaca gcggcatcgc tctcataaaa cgttaagaac 2647141 ggtgacagct cttctttgct taattgaaac caatcagcta aaaacttttt tatataataa 2647201 cggccggtat gaagctggtc gactaccgca taaatttcag tgcggttgca ggttgagaca 2647261 atgatgtttt caagaatgct tttctcttct ttcagctgca ccattgcttc tgccagctca 2647321 ttcggctgaa aacttacttt ttcacgtatc tcaatagggg cggatttata atctactccc 2647381 acaacaagta tatgcatcgc tctaattaca cccccaacac ccaatcttaa tttataatca 2647441 ttctaacata gaactcatta tttataataa ttataacata gtttctttca caaaatgtga 2647501 acagatttta aaattcttat gctatattag aaaaagcttc agggaaaaga agcattccta 2647561 ttgacaatac caaaaacagc agaaatttac tacacatcag ctctaaaaaa caagaaggtg 2647621 atatgcatga aacaaaaatc aattttattc ccttgtctgc tgcttgccgc ttctgtatat 2647681 gcatggctag aaagcggcca agccgaactg ttttcagggc aggatcaatg gcctgttctc 2647741 ctcatgctgt taggcgcagc ctttgtatat caaggaaaaa aagaagccgt cacaccccat 2647801 ttttttatcg gtttgcttct cttcgggatc ggtttacact tttttgccaa gccgaaatgg 2647861 gtatggtggc cggatgattt tgaaatgctc ctctttatga tcggcttctc acttctcgtt 2647921 tcaaccgttc aaaaaaaaga atatgtatat gaagctgtgt cgatgatttg tttttccctg 2647981 tttttgtact ttttcaaaca aattatggca tggcttgagt ctgcgcatat tccaacagcg 2648041 cttctgaagg agtattggcc gtttgtcttt attggaatca gtttattgtt attattgata 2648101 aaacgaaaaa aatctatacg ataaataaaa ccggtagagg atcctctacc ggtttatcat 2648161 ttttttgatc gctccccaag cttcgtcttt tccctttttc gtttctgaag aaaagaggat 2648221 cagctcgtct tccggatcaa tatttaatgt ttgtcggaca accttcgcgt gtttgtccca 2648281 tttacctttc gggatcttat ccgcctttgt agcgataaca ataacaggaa tgccgtaata 2648341 ctttaaaaat tcatacatct gtacatcatc attagatggc gcatgccgca aatcaacgat 2648401 ctgcaccaca gcttttaatt cctcgcgtgt cgtgatatag gtttcaatca ttctgcccca 2648461 tgcttcacgc tcagactttg acactttggc aaaaccgtag cccggcacat ccacaaaatg 2648521 cagctcatca ttgataatgt agaaattaag cgtttgtgtt tttcccggct ttgatgacgt 2648581 tctcgcaaga tttttgcgat tgattaatga attgataaaa gacgattttc ctacgttcga 2648641 tcttccggcc aatgcgattt ccggaagccc cccttcaggg tactgttccg gttttactgc 2648701 actgatcacg atttctgact ttgtgacttt catttcttct ctcctactaa ggcatgttcc 2648761 aaaacctcgt ctaagtggga cgccaatata aatgtcagcc cctccctgac gctttccgga 2648821 atatcctcta tatctttttc attatcttta ggcgcaataa tggtcgttaa tcccgctcta 2648881 tgtgcgccaa gcgctttttc ctttaagccg ccgatcggca gcacgcgccc gcgaagcgtg 2648941 atttccccag tcatgccgac ttcacgcgaa accgcccgtc ccgttaaagc agaaacaagc 2649001 gctgttgcca tcgtaatacc ggctgacgga ccatcttttg gcaccgcacc ctctggtaca 2649061 tgtatatgaa tatcatactt ctcatgaaag tcaggttcaa tgccaagttc ttctgttttg 2649121 gatcgcacat agctgaatgc agcctgagca gactctctca taacatctcc gagctttcct 2649181 gtcaggatta atttcccttt tcccggtgaa agcgatactt caatcgaaag cgtatctccg 2649241 ccaacggttg tatacgcaag ccctgtcact acaccaactt gatcctctgt ttcagcttgt 2649301 ccatatctga aaatgcgttt tccgataaaa tcttgaaggt tcttctcagt aaccgtaatt 2649361 cgttttcgct cttcagcaac aatggctttt gcagctttac ggcaaattgc ggcaagctgg 2649421 cgttcaaggc ttcttacacc cgcttctctc gtatagtaac gaataatatc aagaatcgcc 2649481 tgatcacgca gctgaagatt gcttttcttc agcccgtgtt ctttgatttg ctttggaagc 2649541 aagtgatcct ttacaatttc aagtttttct atttctgtgt agcctgcgat attaataatt 2649601 tccattctgt ctctgagcgg gcccgggatt gtggccaaat tgttcgccgt tgcgataaac 2649661 agcactttgg ataaatcaaa ggtttcttca atatagtgat cactgaagct gctgttttgc 2649721 tctggatcaa gcacttcaag catagcggat gatgggtctc ctctaaaatc agatgacatt 2649781 ttgtcaattt cgtctaataa gaagaccgga ttcagcttgc ccgctttttt catcccttga 2649841 ataatacgtc caggcattgc tccgacatag gtccgtctgt gtccgcgtat ctctgattca 2649901 tcccgaactc ctccgagtga gattctgacg aatttgcgtc ccaagctttt tgcaattgat 2649961 ttggctaaag acgtttttcc gacacctgga ggtcctgcca aacagagaat cgggcctttc 2650021 agggattttg tcagcttctg gacagccaaa tattctaaaa tacgttcttt tactttttca 2650081 agcccgtggt gctcttcgtc caagagacgt cctgcttctt tcaaatcaag cttatcatct 2650141 gtttcatccg tccacggaag agcaaccagc cagtcgatat agttgcggat cacagagctt 2650201 tccgcagaac ttgacggaat tttttcatat ctgttcaatt ctttaagcgc tgtttctttc 2650261 acatgatcag gcatgcctgc ttcttcgatt ttttccgtca gcgtctgaac ttcgccagtt 2650321 ttgccttctt tatcgccaag ctctttttgg atcgccttca tttgttcacg caagtagtat 2650381 tccttctgcg tacgctccat cgaacgtttg acgcgctggc cgattttttt ctcaatctcc 2650441 agcacttctt tttcattatt aataaaatca atgaccttgt tcagcctgtc tttgacatca 2650501 gccgtttcta aaatatcctg cttatccttt agtttaaggg gcagatgaga agcaacgatg 2650561 tctgccattc tccccggctc ttcgatatca gtaaccgcag cgtacgtttc ggccgagatt 2650621 tttttagaaa tttttatgta ctgatcaaag tggtctagca aagtccgcat caatgcttcg 2650681 tcttctgtat cttttgaatc atcttcatga ataagttgaa tgtcaaccga cgtgtaatcc 2650741 tcgtgttcat tgtatttgac gatatgggcg cgcttgaggc cctccaccaa cacacgaatc 2650801 gtaccgttcg gaagcttcag catttgctta atttttgtat aggtgccgac agtgaaaatc 2650861 tcgtcttcac caggttcgtc tatcgaaata tcctgctgag tggctaaaaa tatcatatga 2650921 tcatgcatca ttgcctgttc aagagcctga accgacttgt cacgtcctac atctaaatgc 2650981 aaaaccatcg tcgggtacac taataaacct cttaaaggga ggagcgggat gctgcgtttt 2651041 aattcttctg ccatgtgact gacacctccg tgactttagt atgaaccatt ataatacaac 2651101 tttttcatcc ttgtacaata aacggcatgg ttccattttc tataaaacag tctcctcgta 2651161 gtataccctt tctttctgat atgaaaaagg aaaagatgtc cttcatgaaa aaaaccctat 2651221 tatcaaaata gggtttaaac ggattcttta ttgatttcga tatgaaacgg tttttgttcc 2651281 gttggcggat tcaccaaaat ttcatcaagc acttcttgga acgtcttcac tgcaataatc 2651341 tcgatcccgt caatctgctt taagatggcc tgctgatttt catatgggat aatcaccttt 2651401 ttcgcaccgg actgcttggc cgcttttatt ttcggaatga cgcctccgat gggtttcaca 2651461 agaccgttca ggctgatttc gcccgtcatc gcaacggtat tgtcaatagg aattttgtgt 2651521 atcgccgaga aaatccccgc cgccatcgca atgcctgctg acggcccatc aatcggaatc 2651581 cctcctggga aattgatgtg aatatcataa tcagaaggct tcattcccat tgtccggagc 2651641 acggttaata cattttcaac cgaacccttc gccatgcttt ttcgcctgat cgattttgat 2651701 tggctgccga tgctttcttc ttcagctatt cctgtgatgt taattgatcc tttatcttga 2651761 gccgcggtta cacttacttc gatttccaga agcgatccgc tgttaggccc atagactgca 2651821 agcccattta caatgccaac ctgtggttca acaccgattt tttgctcgtg ctttggagta 2651881 agctgactgg agtgaatgac ccattcaata tcctcaatcg taatgtcctt tcgattctcc 2651941 gttacagcca tccccgctgc gatttgaatc atattgacgg cttcccgccc gttccgcgtg 2652001 tagctggtca aaagatccag tccttcttcg gagatatttt tttcaatttt atccgctgct 2652061 gttttggcaa ccgttttcag ctcgtccttt tcaagctcgc ggaaaaaaac ctccaaacag 2652121 cgggaccgga tagctggcgg aatttcgttt ggcattctcg tggtcgcgcc aatcaagcga 2652181 aaatcagccg gcagcccatt ttgaaaaata tcatgaatat gattcggaat ttgtgtattt 2652241 tcctcactgt aatacgcact gtctaaaaag acttttctgt cctcaagcac cttcagcatt 2652301 ttattcattt gaataggatg cagctcccct atttcatcaa taaacagcac accgccatgg 2652361 gcatgggtga cagctccctg cttcggctgc ggaatcccag cctgtcccat cgctccggcc 2652421 ccttggtata tcgggtcatg gacagagccg atgagcggat cggcaattcc tctttcatca 2652481 aaacgggctg ttgtcgcatc gagttccaca aagacagcct gctctttaaa cggtgattgt 2652541 ttatgttttt ttgcttcttc caacacaagc cgcgcagcag ccgttttccc aactcccggt 2652601 ggcccataga caatcacatg ctgaggattt ggcccgcata aagccgcctt taatgcttta 2652661 atgccgtctt cctgtccgac gatatcttta aagcttttgg ggcggacctt ctcagataat 2652721 ggctcggaca agctgatagc gcgcattttc cgaagctgct ccatttcctt ctttgattct 2652781 ttatctatcg tgaccttttg tgtcctttga tttttaagca aattccaaaa atacaaaccg 2652841 atgatgatcc caaaaaacag ctgaataaat aacgcgatcc ctgtccaact catggtggtc 2652901 cctcctgaaa aacaatttat gtatccaatt cattcctctg attgctagta tctcccatag 2652961 aagacgggaa taaacgtttt tccggaagag ttgcatgcaa aaaaacctcc tgagtgttac 2653021 cactcaggag gtttgtgctt atctttatgc agatgtttta tcttggctta cctcagtgcc 2653081 gtcttttaat aagaggcgag gaggctctcc gtgtgtcaca gttgccccgg tgattacaca 2653141 tttttcaatg tcatcacgag aaggcagctc aaacatcaca tcaagcatga tgccttcaat 2653201 gatagaacgg agtccgcgtg ctccagtctt gcgttcaatt gcttttttag caatttcaga 2653261 aagcgcttct tcttcaaact caagctcaac gttgtcaagc tcaagcattt tcttgaattg 2653321 cttaacaaga gcgtttttcg gttttgttaa gatcgcaacc aatgcttctt cgtcaagctt 2653381 ttcaaggctt gcaataaccg gaagacgtcc gataaattca ggaattaacc cgaaacggag 2653441 caaatcttct ggaagcactt ttgaaagaag atcttctttc tcaagatcag cagctttatt 2653501 gtcggcaccg aatccaatca ctttttggcc taaacggcgt ttgatgattt gttcgatacc 2653561 atcgaaagct ccgccgcaaa tgaacaaaat atttgttgtg tcaatttgaa tgaattcttg 2653621 atgaggatgc ttacgtccac cttgaggcgg tacgcttgcc actgtaccct caagaatttt 2653681 aagcaatgcc tgctgtacac cctcacctga cacatcacgt gtgatagacg ggttttcaga 2653741 ttttctagcc actttatcga tttcatcaat atagataatg cctttttcgg ctttttccac 2653801 atcataatca gcagcttgga tgagcttcaa gagaatattc tctacatctt cacccacgta 2653861 tccagcttca gtcaaagatg tagcgtccgc aatcgcaaac ggcacattta aaatgcgagc 2653921 caatgtttgc gccagaaggg ttttaccgct tcccgtaggg ccgattaatg aaatattact 2653981 ttttgaaagc tcaacatcat caactttgct gttggagtta atgcgcttat agtggttata 2654041 cacagcaaca gcaagtgatt tcttcgcttg atcttggccg atgacatatt cattcaaaat 2654101 ttcgcgaatt tcctgaggct ttggtacgtc tttaaattct acttcttctt ctgttccgag 2654161 ttcttcctct acaatttcag tgcagagttc gatacattcg tcacatatat atacaccagg 2654221 tccagctaca agcttacgaa cctgatcttg tgtttttcca cagaacgagc attttaattg 2654281 tcctttttcc tcgttaaatt taaacattct ttcacccctt aatcttgtct cactttttct 2654341 tttaccggca gagcaaaaga aaatgattct tgaaacgaac gagtatgtat tgcattttac 2654401 catactttcc aaaaagacgg taacaatgtg tttctgactt gcacattcta tatgtatgac 2654461 aaaaaacagc cctgcattaa ctatattgcc ccaagaaaaa gagataactc ataattgtac 2654521 aaaacaaggc acgaatgatt cgcgccctgt tttattagta ctattattat gcaccatatt 2654581 aacggttttc tacaagaaaa tcaattgctt tgcgaacttt taaatcttct ttcatcgcgt 2654641 cagtagaacc gatggcttgt ttaatatttt caacaggcat gttgtatgct tcagccattt 2654701 ttgtaagctc agcatcaact tcctcatctg atacttcaag gttttccgct ttcgcaatcg 2654761 cctcaagagt caggttagat tttacgcgtt tttcagcatc ttctttcatt tgctctttaa 2654821 gcgcagcttc atcttggcct gagaattgag tgtaaagctc aaggttcatg ccttgcattt 2654881 gcagacgctg ttcgaattct ttcagcatgc ggtcaagctc agtgtcgacc attgcttgag 2654941 gcacatcgat ttcagcattt tcagaagctt tcagaacaag ctcttcacgc aatttagcgt 2655001 cagcttcgtt ttcttttgct tcttctaaac gtttctttgt tttttcagtt aattcagcaa 2655061 gtgtttccac ttcttcatcg atatcttttg cgaattcatc gtcaagctca ggaagctctt 2655121 tcgctttgat ttcgtgaatt ttcactttaa acacagctgg tttgcctgca agatcttcag 2655181 cgtggtactc ctcagggaat gtcacttcaa catccttctc agcacctgct tcaaggccaa 2655241 ctaattgatc ttcgaagcca gggatgaatg aaccagaacc tacttctaga gagtagtttt 2655301 cagcttttcc gccttcgaaa gcttcgccgt caacgaatcc ttcgaaatca agaacaactg 2655361 tgtttccttc ttcaacggcg ccttcttctt ttacaacaag ctcagcttga cgctcttgaa 2655421 gggcttttag ttcgttttga acatcttcgt cagttacagt tgtgtcgtct ttttcaatgc 2655481 ccaggccttt gtattcgcca agcttcactt caggttttac tgttactttc gcagtgaaga 2655541 ttaagctttc gcctttttcg attttttcaa catcgatttc aggacggtct acaggctcga 2655601 ttccagcttc ttcaaccgct ttagggtatt ctacaggaag aagaatatcc aaagcatctt 2655661 ggtaaagagc ttctacgcca aagcgctgtt cgaataatcc gcgaggaatt ttacctttac 2655721 ggaatccagg aattgaaact tgttttacta cttttttaaa tgcatcatca agtgctgttt 2655781 taaacgtttc agcatcaact tcaaccgtta aaacgccttc gttgccttct tgtttttccc 2655841 attttacaga catgtgtttc cctccaaaaa tctattcagg ttgtgtcggt cttccattct 2655901 aaagcaatca ttcggcttcg tccaacaaaa acaaagctgc caaagatcag aatcattatg 2655961 tatagatgtt aataatgaac tgcaaagcct gtccaaccgt atttcttata acccgttata 2656021 cacaaataca accactatat tataacataa cacatagcgc tttcaactat atggcgcgat 2656081 ttacaaataa gaaatttctt caatatcttt taacattgtg caagcttcat cgagttctct 2656141 gtctgtaaat tcatacatca tatgaagttc ttcgctttca atttcaatcc cgtgcatctc 2656201 gtaaccgact ttatgaaggg cagccgccca aaggtcagcc gacagcaatt tcggctggaa 2656261 cggatataaa acgtacaaat gtcttctcca caattcttct actgctgcat ataaggttgg 2656321 attttcattt ccaagtgtct catctagcac cctgagaaca cggtgaagaa tcggcgcggc 2656381 atcaggcgga acaatctctg acggttcaat tgtcaacgac tcgccaaatt tactaatgtg 2656441 tacaggttta ctgtactcat gctcagccaa cagcatgaca atcatcgttt tgataatcgg 2656501 atgggctgag gggtcttgga ggattgtttt gagcaatcct gtatactttg ctacgttacg 2656561 gtcttttaag gaatgaatga gattcatttg ctcctcaggg cttgccagca ctttctcggt 2656621 gtcaattgta tcctcatatt cttcggccca agcctcgtcc tcacgatccg gatcggtcat 2656681 tttccggctg aaatccagca gcttataaaa ttgctcggca ctttctgccg gcagctgatt 2656741 ttcttccaaa acggcttcaa tggtgctttt gacttcttcg tactttttga gctgaattaa 2656801 gatggtcatg tacacctgca aaaccgtaaa ataatggcca taaccttctt tgagcatctt 2656861 ctcgcacacg ctttctgcct cttccagctc gcccagctct aaaaagcaga tggccatccc 2656921 taagtgaaga tcggattcag tatcatcata tttcatcgct tctgaaaaca gttcaagcgc 2656981 ttcttgatac tttttttcct tgagtgatga catccctttt tccacaaggc ggtctttcag 2657041 atgaggaaaa ggaataattt ttgcgttttt cttgtcatgc gtcataccta tattcctttc 2657101 aggcatttat tttgttcaag tgtatcaaca cctgtgaaca aaaacaagaa atgaaaggtt 2657161 tcaccaggca aaaaaagccg ccggacaaat accggccgct ttttcaggct tgaagccaag 2657221 agcttctttg tgattcaaat tgcttgattt catcttccag cagcagcgtt aatgaaattt 2657281 catcatatcc gttgatcagc atctctttcc aatgcggatc aacttcaaat gaaatttgat 2657341 tgccttcact gtcatgaatc agctgatttt caaggtcaac agtcatttgc aatgactggt 2657401 tttcatactg gccgacaagc tgtttccaat tgtcatatgg catgcggatc ggaagcatgc 2657461 cgtttttaaa gcagttctga tggaaaatat cagcgaatga cggcgcaatg ataattttaa 2657521 acccataatc atcaagtgcc cacggagcgt gttcacgcga tgacccgcag ccgaagtttt 2657581 ctcctgctat taaaatggaa gctccttgat aaacaggctg gtttaattca aattcagggt 2657641 tcggttcacc attcgcatca tatctccagt caaagaatgc aaaacgtccg tagcctgttc 2657701 tttcaatcct cttcaaaaat tgcttaggaa taatctggtc tgtatccaca ttgatccgat 2657761 ttaatacggc tgctttcccc gtatgtgatt tcaaaggttc catctcgcgc actccttaca 2657821 caactgtttt ttcctgataa aactttctga catcaacgaa gtgtccgtga atggcagcca 2657881 tcgcagccat tgccgggctg acgagatgtg ttcttgcacc ttttccttgt ctgccctcga 2657941 agttgcggtt agaggttgat gcacagcgct ctccctcagg aacaacatca ttattcatac 2658001 tcaaacacat gctgcagcct gactctctcc attcaaatcc agcttccaag aaaatctggt 2658061 caagcccttc tttttcagcc tgaagcttca cgctttggga tccgggcacg acgatggccc 2658121 ttacgctgtc agctaccttc ttccctttga tcatgtcagc agcctgtcga aggtcagtca 2658181 tgcgggaatt tgtgcaggaa ccgataaata cgtgctccac tttaatgtct tcaatttttt 2658241 ggtgaggagt caatcccata tattcataag cacgaatcgc ttctttttta tcgtcttctg 2658301 cagaaaagct ttccggcgca ggaacttcag aatcgacagg aagaaccatt cccgggttaa 2658361 tgccccatgt caccataggg gaaattttgt tgccgtcaag gacgatagat ttatcgtaaa 2658421 cagcgcccgg gtctgtgcgc agcgccttcc attcctctac ggccttgtca aattcttcgc 2658481 cttttggcgt gtacttgcga tttttgcaat attcaaacgt cacctcgtca ggtgcaatca 2658541 aacctgctct tgctcctgct tcaattgaca tgttacaaac agtcattcgt tcatccatcg 2658601 tcatatttct gaatacttcc ccagtgtatt caatgacgta gcctgtgccg aatttcacac 2658661 cgtatttgcc gatgacagca aggatgacat cctttgccgt tacccctttt tgaagcgttc 2658721 catctacgcg cacttcaagt gtttttggac gctgctgcca aagtgtctgt gtggaaagga 2658781 catgttcaac ttcactcgtc ccgattccaa atgcaagagc gccgaaagcg ccatgtgttg 2658841 atgtatgact gtcaccgcac acaatcgttt tccctggaag cgttaagcct agttcaggtc 2658901 cgacgacatg gacaatccct tgatccacac tgtgaagatc ggcaaggcgc acgccaaatt 2658961 cctcacagtt tctttcaagc gccgttacct ggcgtttcgc aacttcatcc tttatctcaa 2659021 aacgattgac agtcgggatg ttgtggtcca ttgtcgcaaa tgtgttttgg ggtcttctga 2659081 cctttcttcc cttttgtctc aagccttcaa atgcctgagg agacgtcacc tcatgaatga 2659141 ggtgcaaatc aatatagaga agatccggct ttccctcacc atgttttaca atatgctgat 2659201 cccaaatctt ttcgatgatt gttcgaggca tcatctttta tttcctccct ctacctagag 2659261 ctaagaccgc ttaacgtaag ctgtcacaca ttagaaattg tattttcact catgattgct 2659321 gccttaactt cctctgtaat ggcctgagtg ctgctgaact cttcactccg tgccaagtct 2659381 cttgttcttt ttccagaagc caagactttg tttaccgcat cttctacagc tttcgcttcc 2659441 tcttcaagcc cgaaagatgt tctcaaaagc attgccgctg acaatatggc tgcgaacgga 2659501 tttgccatcc ctttaccggc aatatcaggc gcggagccat gaacaggttc aaacagatga 2659561 aggccagagc ttgataggct ggctgacggg agcattccga gcgagcctgt aagcatggac 2659621 gcttcatcgc ttaaaatatc accgaacata ttttcagtca ccacgacatc aaattgattc 2659681 ggtgcataaa ttagctgcat ggccgcgtta tccacaagca tgtgctcaag cttcacatca 2659741 ggaaattctt gtgcaacgtc ctcagccact tcacgccaca gccggcttga ttcaagaaca 2659801 ttcgctttat ctacagaggt cactttgcct tttctggctg ccgccatttt gaagccctct 2659861 ctgatcactc gttcaatttc cgttcgctta taaaacagtg tatctactgc ttcctgctca 2659921 ccttcagtgt ttacataacg tttgctcggc tggccgaaat acaagccgcc tgtgagctca 2659981 cgaacgataa cgaaatcaac attatctata tattcttttt tcaaaggcga agcgtcagaa 2660041 aggctttcaa ataccttcac aggccgcaaa ttcgcaaaca aatcaagctg ttttctgatg 2660101 ctgagcagcc ctttttccgg tctcagttcc gaaggatttt gatcccattt cggtccgccg 2660161 acagcaccaa gcaatatcgc gtctgcattt ttacaagcag caacggtttc ctccgggagg 2660221 gggttatgat gttcatcaat agccgcccct ccaatcaggc catattcaaa ttcaaattca 2660281 tggttaaagc gttcggcaac acttttcagt acgtctgtcg ctgattctaa tacttcaggg 2660341 ccgatcccgt ctccgggcaa tagagcaata cgtttcttca agttaaccgt tctcctttct 2660401 tttatgatcc gacagctgtg tggtttttca atccgctcat attcgactgg aaaaccaatt 2660461 gacggtttac tgcgttcaaa taggctttcg ctgatgcttc taatacgtct tgcgctatgc 2660521 cccgccctgc tgattctttt ccgttcacca aaactcttac atacacctgg gcaaatgcat 2660581 cttcgccttt tctattagac tgaatgcggt agtctaagag ctccacatcc ttatcgatgc 2660641 agcgctcaag cgtattgtag attgcttcca cgcttccagc tccagttgca gcttcctgaa 2660701 taagctgtgc gttttcttga tttttcaaag atagagtagc cgtagggacc tgacttgttc 2660761 cgtaatgtac ttgcagagaa agaaattcat acccaatctt gcgatctgtt actttttctt 2660821 ctaaaataag agaaacaaga tcctcatcag tgatttcttt tttcttctca gtcaactctt 2660881 tgaacatcgt aaagaattta ttaatctctt cactgtcaaa ttggaatcct aaagcagtca 2660941 gccggtcttt aaatgcgtgg cgtccggaat gtttacctag gacaagcgca tctgcggtta 2661001 cgccgacaag ctccggtgaa ataatttcat aagtcgattt ttcctttaaa aagccgtcct 2661061 gatggatgcc tgattcatga gcaaatgcat tatctccaac aaccgctttg ttgcgcggga 2661121 cagccatgcc tgtcagtttg cttactaaat cacttgttct cttaatctcg ttcagcgtaa 2661181 tacctgtttc gacttggtag aaatcttttc tggtatggag ggctacggca atttcctcta 2661241 atgccgcgtt tccggctctt tcaccgatcc cgttcacagc gcattcgatt tgatcagcgc 2661301 cattttcaat cgcagcaaga gagtttgcga ctgccattcc caaatcatca tgacagtggg 2661361 ctgaaagctt tgctttgtga atgttcggaa cgttttcttt catatattta aagatatttc 2661421 cgtattccgc cggggccagg tagccgacag tgtccggaag attgataaca ctggcgcctg 2661481 cgtcaatcac tttctcgacg atttctgcta gaaacggcag ttcagtgcgg caggcatctt 2661541 cagctgacca ttgcacaatc ggaaaacgtt cttttgcgta tttcaccatt ccaactgctc 2661601 tttcaatgac ttgttcacgt gtcattttca gcttgtgctt caaatgaatg tccgatgtcg 2661661 cgataaatac atgaattctt ggttgagcgc catcctttaa cgcttcccaa gcagcatcaa 2661721 tatcaccttt tacacaacgg gccagaccag ttactgaaca atttttaatg gttcttgcga 2661781 tttcctgaac agctaaaaag tcacctcggg acgaagcggg aaatcccgct tcaatgatgt 2661841 ctgccccgag tctttcgagc tgcttagcta tggcaagttt ctcctgtgta ttcaagttca 2661901 ctccagggga ctgttcacca tcacgaagcg tcgtatcgaa aaaattaatt ttgcgcaacg 2661961 gagaccaccg cttccttctt cttgccttgt ttcacaaacg gcatcatttc acgaagcttt 2662021 cttcccacta cttcgatttg atgttcgttc tcgcttgcat tgatagcgtt gaaacgagga 2662081 cggtttactt ggttttcgac gatccactct tttgcgaatg taccgttttg gatatctttt 2662141 aatacttctt tcatagattc ttttactttg gcgtccacaa cgcgagggcc tgatacgaaa 2662201 tctccccact gtgctgtgtc agagattgaa tatctcattc ctgcaagtcc ttcttcgtac 2662261 ataaggtcta cgattaattt cagctcatga agacactcga agtatgcaag ttcaggctga 2662321 taacctgctt cagttaaggt ttcaaatccg gctttgacaa gcgcgcttaa tccgccgcaa 2662381 agaactgctt gctcaccgaa caaatctgtt tctgtttctt ctttaaatgt cgtttctaat 2662441 acgcccgctc ttgcgccgcc gattccttta gcataagcga gggctttgtc tcttgcttct 2662501 ccagtcacat cttgatagat tgcgaacaat gcaggtacgc cagctccttg ctcatatgtt 2662561 cttcttacca agtgtcccgg gcctttaggg gccactaaga atacatctac atccgccgga 2662621 ggaacaattt gatggaaatg cacgttaaat ccatgagcga atactaatga ttttcctgct 2662681 gtcaattcat ctttgatttc agcttcgtat actttttgct gctgctcatc cggaagcaga 2662741 accatgatga tttcggcttg ggctgccgct tcttttactg aaaatacttt atgtccgtct 2662801 tcttgggctt gagtgaaaga ttttccttgt ctaacaccga cgatcacgtc tactccgctt 2662861 tctttaaggt tcagggcatg tgcgtggcct tgcgaaccgt acccgataac cgctactgtt 2662921 tttccagcca atacgttctc tttgatatca ccgttataat atacttttac catttcaatc 2662981 tctcccttgt tatgttttat acaatagata ttgttttatt ggatgacgcc ttttgctggg 2663041 ttcccctcgc aaaagccgtt gtacctgttc tcgcgatttc tttaatgcca taaggtttta 2663101 ataactcaat aagcgcttca attttgttag attcacctgt cacctgaaca acgatgctgt 2663161 ctctgctgac atcaacgaca gaggctctaa acggttctat gattccatta atctctgttc 2663221 ttgttgaagg tgcggagaca accttgatta aggccagctc cctctggaca atcgattgat 2663281 ttgtgatgtc tgtgactttc agcacatcaa tctgtttgtt gagctgtttc gttaactgtt 2663341 caacatcatt ttcaccttca acatgaacga cgaaggtgat tctggaaacg ccggctgttt 2663401 ctgtgtgtcc aactgtaatg ctttcaatgt tgtaatgcct ttttgtgaat agaccggtga 2663461 tccggtttaa caccccggag cggttcacca cagtcaatgt gataattctt ttcaaggttt 2663521 cacccccacc atttcatgca gccctttccc cggagccacc atcgggaata ctttttcttc 2663581 gctggcaacc cgcacgtcaa tgacaacagg ttctcttgat gttaatgcct cttccagctt 2663641 ttcctttgct tccgcttctg atgaaattct gatgccttta atgccgtatg cttcggacaa 2663701 tttgacgaag tcaggctgag aagcgaattt agattctgaa taacgttctt catagaaaat 2663761 ttcctgccac tgtctgacca ttccgagaca agcgttattt aaaatcacta ccttgaccgg 2663821 aagatttaat tcgcgaataa catcgagttc ttgaagcgtc atttggaatc cgccgtctcc 2663881 gacaaccgcg acaacagtag catctttttc ggccagctgt gcgccgatcg ccgccggaag 2663941 accgaatccc atcgttccaa gtccgcctga cgtgacccat ttatctgctt tttggaacgg 2664001 ataaaattgc gctgaccaca tttgatgctg gcctacatcc gttgcgacaa tggcctctcc 2664061 ttttgtaaat tgatgaatat attcaatcaa tttctgaggt ttaaaacctt cttcttcatt 2664121 atctacatac cagagcggat actcttcttt ccattctgcg agctgttttt tccattcgct 2664181 tgaatcgctt tgtttgccgt cttgtttgat cagctcctgc aggacaattt tgctgtctcc 2664241 gactacagga atctgtgttt tcatgatttt tccgatttca gctggatcaa tatcgatgtg 2664301 ggctatcttt gcgtttctgg caaagtgttt caggtttcct gtgacacggt catcaaaacg 2664361 ggcgccgata ctgattaata gatcacattc atgaagggcc atattggctg tataagtacc 2664421 gtgcattccc gccatcccta ggaaaagcgg atggtcagcc gggaagcctc cgagccccaa 2664481 aagggtgtgt gccacaggga tttgctgctg ttcagcataa ttttttaatt cttctgacgc 2664541 ttttccgtgc agtacgcccg cacccgccag gatcaccggt tttttcgcac tgctcacggc 2664601 ttccacaagc ttgcggatct gcaaataatt cggctctgtt gtcggctggt atcccgggag 2664661 attcatctca tgatcgtagc tgaattctcc ttcaattgtt gctacatctt tcggaatatc 2664721 aatcaataca ggtccgggtc ttccagttgt tgcaatatgg aacgcttctt taatgatgcg 2664781 cggcagatct tccggctggc gaacctggta gctgtgtttt gttactggca tcgtaatccc 2664841 taaaatgtct gcttcctgaa atgcatcgct cccgattaca gaggttgcta cctgccctgt 2664901 aaagacgact aacggcaatg aatcaatcat ggcatcagca aggcctgtaa caaggtttgt 2664961 cgctcccggc cctgacgtgg caatgacgac acccggtttt ccggagaccc ttgcgtatcc 2665021 ctccgctgca tgaattgctc cttgttcgtg acggggaagg atatgtacca accctgaatt 2665081 gtatagctta tcgtaaatcg gaagcacagc cccgcccgga taaccgaaga tcatttctac 2665141 tttctctttt tttaatgatt caatcagcat taatgctccg ctcatcgtct gtgtacattc 2665201 ggcagatgct gaatccacct gtacattagt ccccatttta gttcctcctt ttggattttc 2665261 atcctttaaa gatcatcttt tcattagcta gatagctgat tattcaataa aaaaagccct 2665321 tccgcccaca atcagccgcg cagtaactgc gatagctaaa aggggcgaaa aggcttttct 2665381 ttccgcggta ccacccttgt ttacggcctg ttaatcggcc gtctcatgga tatttctatc 2665441 cgctttagta acgagtgaat caagttcacc cggccaagtc ctactgtcat ttcagactgg 2665501 cactctgagg cgagttcacc ttgtaaagct tcgccggttc tcagctaacc cggttctctg 2665561 tggaaaactt tatcaaggct acttatcctc atctgcgctt ttcatattca gccttcggaa 2665621 cggctttcca gctgttcaag aaggtcgttt gtttttcatt tttttagaat catactgcga 2665681 tgattttcgc ttgtgaagct tgcatttatc ttttgttgaa ctcatattac gccgctttgg 2665741 acgcagtgtc aacagcattt tttaaaatta ttagacaatt ttgattaatc aatctatatt 2665801 gtatacgctt tcattattgg tacaaaagga attgcaaatg ttaaaagttt ttataatttt 2665861 tttattaatc tatcaagaat acaccagaat tatttaattt tatataaaca tggaagattt 2665921 tataacacga tatggttcgt atatggattg agtctgacag atcatcttgc aatccatttc 2665981 aatttcggat aggcacttct cttgttccct cggcatacat taatgatatc ttgcaaagaa 2666041 aaggtgatac gatgaataaa tcatttgcag acatgcaagg atttcctgcg ggctttccaa 2666101 gcttccccaa ctttccgcag cagtactatc ctgctgtccc tcccttttac cagcaaagcc 2666161 agcagccatt tggaggctac ggatacggac agccgttcag tcaggcatac agcccgttaa 2666221 ccactccctc tggaatgtac tcctcattcc catacgcttc aggattttac ggacagcaat 2666281 tttcaggtgc aggctttagc ggccatggcg gcagcttaag tgctccagcg atacatgccg 2666341 gcggattcag cggggcgcca ggcgtacacg gaggctttag atattaaaga ataccacaag 2666401 ggccgaacat ctattgcggt ccttttattg ttttaaaacg acttcacaag tacagtcaca 2666461 ttttctgtct ttatatttgg aaacaggatg gaatatgatt aagatgaatt gaacgatatt 2666521 ctgcacaatc cgtaagtttt cgaggaggaa taaaattgca tataaaaata gacgatttaa 2666581 ctggacgtca ggtggtttca ctggtgaatg agcatttaca tagcatgacg cttatgtccc 2666641 cgccagaaag cattcatgcc ttaggtctag aaaaactaag agggcctgaa ataacatttt 2666701 ggagcgcatg ggaaggtgat gaactagctg gctgcggagc gctaaaagaa ctggacaccc 2666761 ggcatggaga aatcaaatca atgcgaacat ctgcatcaca tttaagaaaa ggcgttgcca 2666821 aacaagttct ccagcacatc attgaagaag ccgagaagcg aggctatgag cggttaagct 2666881 tagaaacggg ttcaatggct tcatttgagc cggcaagaaa attgtatgaa agcttcggtt 2666941 tccagtattg tgaaccgttt gcagactacg gtgaagatcc aaacagtgtg tttatgacga 2667001 agaaattgtg agacggcttt ataaggatag ataagtgcag gggaaggtct gtcttatcta 2667061 tcttttttta tattcacaca tttttcacct ttatgataca cgccaatgtt ttcaattttg 2667121 tttaattcaa agaacagcgg gaattacaaa cgacatgaac gatatcatgc aaattcataa 2667181 aggaggagat tgatatgaaa agcatagttg gtgtatatga aactccgcag gaaaccatcg 2667241 cagcgattga aggcttactt acaaaaggct atgattctga tgacatttct gttgtgacaa 2667301 gccggcgaga tacagattat ttggagtcac gtacaggaac agaagtcaat caagctatcg 2667361 atgcacatca ggacgaatct gaatcttttt tcgataaact gaaagattat ttcacaatgg 2667421 atgatactgc tacacacagc aaagcattat ccgacttgga tattaaaact gatgaaatag 2667481 acaagtatca agaagatttg gatgacggaa aacttctggt agccgtcgat acagatgcag 2667541 atgtaattgc tcctattgat aacggcaatg ccctttcagg cggcttttca agcacaaatg 2667601 aattggatta tacaacgaaa gaagaaaaaa cgatgccgct ccgggaagaa cagctgaagg 2667661 tcgataagga agacgttcaa accggcgaag tagaaatagg aaaagaagtg aaaacagaaa 2667721 aaagagatat ggacattccg gtgagacatg atgaaattta tgtcgaacgc cgtccagtgg 2667781 atgaaaataa aacggacgct gctcccgtca acgattcgga agagatcaga gttccaatcg 2667841 ttgaggaaaa gctggaagtg actaaaaaac cggttgtcac tgatgaagtg gttgtcggca 2667901 aacgcactgt tgaagaaaat gaacatattt ctgaaactgt gaaaaaagaa gaacctcgtc 2667961 tgaataaaga aggaaaagtt gacggcttgg atgatgatcc gttaaataac aaatgaaaat 2668021 catagaccga caacaaaaaa cctcaaatcc taaatggatt tgaggttttt cttttggtac 2668081 gtcccaggag agattcgaac tcccgaccga cggcttagaa ggccgttgct ctatccagct 2668141 gagctactgg gacacgtttt gtttttttgt ttttcgcttt aactatcagc gacaagattt 2668201 attatatatg ggatgcaata ataagtcaac ggttttttag aatttttttc atgaggaaga 2668261 aaattttctt cctcatgaca ttttcatagt gtgactcgat tttgcagatc ctcaatttca 2668321 ttgcctgctt ggtcgtaaaa acggactgtc gcagcatcat tttctaatgt cagtatagca 2668381 tagctttctg tcctgcgcac cctcggaagc cggatgctgc ctgggttaat catcagtttt 2668441 ccgcgcagca cttcgcttcc cgcgatgtgc gaatgcccga agcagataac atccgccccg 2668501 agctcctctg cacgatagta tacgtttaac aaggtctgtt ttataccgtg aaggtggccg 2668561 tgtgtgacta gtatttttct tgagccggca gtcagaagaa gctcgtcctt aaaatcgccg 2668621 gcaaaatcgc aattgccttt tacaaccgca taaggctcca atgcaggatg cctcgtctca 2668681 agctcagagt ccccgcaatg aatcatgaga tcaacttctg cctcatgccg tttcgcaatg 2668741 gtttggagtt cttcttcaag cccatggctg tcactgataa tcagcacgtt catgtacaag 2668801 cttcctcctt atgcctccaa aagcttagac agctttttaa gcgcgtcagc cctatggctg 2668861 attttatttt tttcatcact tgtcagttca gccatcgtct tatctttatc tttcacgata 2668921 aaaattgggt catagccaaa gccatattct cctctcggtt cttcagcaat atacccttca 2668981 acatggcctt cgactgtttt tgtttcctct ccgggaatac tcacggccag tgcgcagcgg 2669041 aaacgggcgg tgcgctgttc tttttcgata cctttcagct cgctgagcac tttttcgata 2669101 tttgcctggt cgtctttctg ttcccctgca tagcgggctg aataaacccc gggtctgccg 2669161 ccaagattat cgatggatag tccggagtca tccgcaatca ccattttgtt cactgctttg 2669221 gcaacagctt ccgctttcat aatggcattt tcttcaaatg tatggcctgt ttcttcaatt 2669281 tcctctgtga atccaatttc agctaaagat ttgacatcat agcctcttgg ctcaagaatt 2669341 tctttgaatt ccttcacttt tcccggatta tgtgttgcaa taattgcttc tttcatgatg 2669401 atcaagcctt tctgtcttta tttcagttct ggcagagaat cacccagcac ttctttttgc 2669461 ttgtcaatca gctcttggat tcctttttcc gcaagaccca gaagaccgtt cagatcctct 2669521 ctagaaaaag ttgcctcttc cccggttccc tgcaattcca caaaacggcc gctgcctgtc 2669581 atgatgacat tcatgtcaac ttcagcagag gaatcttctt cataatttaa atctaacaaa 2669641 attccctgtt ccttatcaat tccaacagag attgcagcaa gaaaatcagt gatcggattt 2669701 gtcttgattg ttcctgcttt gatcagcttg ccaatcgcaa tcgccatagc aagaaatgcg 2669761 cctgtaatgg aagctgttct agttcctcca tcagcttgaa tgacatcaca gtcaatccaa 2669821 atcgtccgtt caccgagctt ttccagatct acaacagctc gaagcgcgcg gccgatcagg 2669881 cgttggatct ccattgttct gccggaaatt ttccccttag aagattctct gattgttctt 2669941 tggtttgttg cccgcggcag catgctgtac tctgctgtaa tccagccttt ccctccgccc 2670001 cgcaaaaacg gcggtacgcg gtcctcaaca gacgcgttgc agattacctt tgtatttccc 2670061 gctgttatta gaacagaacc ttccggatgg ctgataaaat ccaaatcgaa tgtgattgga 2670121 cgcagctcat cgtgttgtct tccgtcatgt ctcatgtttt acctccgatt gtatgtacat 2670181 aaaccatttt tgtcccggaa ttgaataaag aaagaggcag ccggaacgct aacctctttc 2670241 ttcctagtat atcaaaaatc ccaatttaaa aactacccgt attcacttga gatggtctgg 2670301 agaccggttc tgtgagcttt tcgccttttt catttaccag ctctgatttt ccgttcactt 2670361 taacagagac gctttttaca tccggctgct ccgttaacgt cagcacaatg ctgttcagca 2670421 cttctgaaga aatcattttc gtcttctcat cggcgctgcc gaatatagat tgattgaaat 2670481 ccaacgtcac gcgcccgtct ttgattttcg gtttgctgac cagctttaca tcttcactga 2670541 agtctgttaa cagcccgctc accttgctcg gccctttagc caattcatta atggctgctg 2670601 tgatgtcgtc tttttccgaa ttgtcgattc gtttggtcac cggcacgtag tattcactgt 2670661 cttcattttc cgccaaatag tagactgtca gcggatgggt agcagtgaga tcatttacac 2670721 cggctgtttc caaattaatg ccgtctttgc ggcttaaatc atctgagatc ggcgtccctc 2670781 ctacaggcat ctccttcagt tcatgcccgt ttattctcag cttcacttta tctatcgaac 2670841 taaattgcgt cagcgtccac gtcacagatt gaacgatttt ctgttcgtct tctttcttat 2670901 aatttttgaa ctcattagag aaatcagcta tcgccgttcc atcttttttg atgtcaacgt 2670961 taacggtggt gtcagccggc aatacagctc tgaagccatt cggaagaatt tcagacacag 2671021 gcccgccctg tacgaggtat tcaagcgcct gcttagccgt gctctcactt ttaggaagag 2671081 gcagcgtttg cgcaacaaca tacccgtttt tatcaatgag ataaagctcc ctcataacag 2671141 tagatgaggc ttgatccgct tttgcggtat cgcttttttc actttctgtt tttttggctg 2671201 ctgttgtatt tgaattggca cccgcttcat cgttcacgaa tgtaacgtct tgaggcggat 2671261 caatttcctc ggctgcctta tcagattgaa acaaaccgca tccggataaa agcaaggcag 2671321 aggtgagaca agtggcacca atgactgcag gtcctttttt cagcatactt ttccctccta 2671381 aggatgtttg tactattatg tatacgagcc tctttaggaa atagaccgaa gaattccggc 2671441 aaaacagaaa aaaacccgca acataccgtt gcggggaaaa ctatctttta atcggttctt 2671501 gcagtgagat acattccaca tgcccgactt catggccaaa ccaatcgtct gcgatttttg 2671561 caaactgatc acgcgcccct gttgtcagga actgatgatc cggggcaatc ggagactggt 2671621 tcagcagccc tttataagag agaattgtgc tgacttcccg ggctgtttca tcgccggacg 2671681 aaataatgtt tacgtgctct cccatatatc tttgaatggc ttcttttaaa atagggtaat 2671741 gggtgcagcc taaaatcagc gaatcaattg atgtgtcttt taacggatac agcgaggttt 2671801 taacaatctc gtctgctgtt ttgtcgagaa acttcccgct ttccacaaaa ggcacaagca 2671861 gcgggcaggc aaggttttca accttcaaat cagggtttaa tgccaaaagc gcttcttcgt 2671921 atgcattgct cttaatcgta ttctctgtgc cgatgacacc gatatgctga ttatccgtca 2671981 cttttatcgc tgctctcgca ccaggctgga tgactccgac caccggtata ccgacgctgc 2672041 gctggatgtc atccaaagcg atcgctgttg ctgtattaca ggcgatcacg agcattttga 2672101 tgtggtggtt ttcgagtaaa taattcgtca gctcccacgt atattgaagc acctcttctt 2672161 cagggcgcgg cccgtaagga caccgtttcg tatccccgac gtagataata ttttctttag 2672221 gtagctgtct catgatttcc ttcgcaacgg ttaaaccgcc aaccccggaa tcaatgactc 2672281 ctattggttg ttccaacaaa atcgcctcat tttctcttca tttcatgctg cagtttcatc 2672341 aaagattttt cgaagatggc tatttcttca tctgtaaacg attcgaacat atcacgcaga 2672401 tattcctgtc tttttgtaat gacctcttgg ataatccgtt ctccttcagg cagcagatgt 2672461 atcctgacaa cacgtctgtc cgccgggtcc ttgacccgct caacaagctc atttttttgc 2672521 atgcggtcga ttaagtccgt tgtcgtgctg catgccagat acattttgcc cgataattca 2672581 ccgattgtca tatctcctaa ttcataaagc cattgcaagc cgacaaattg cggcggcgta 2672641 atcgcatatt ggttaaggat ttctcgtcct ttttgcttaa tgatcgcggc aatgtggcgg 2672701 agtgactttt caatatccgc aacatgctcc aaaggttttg atgtcatttg tccatccctc 2672761 actcaaggat ctcttacgca caaaagcgtt ccgtgtctat tttccttctt ttttgaagaa 2672821 aatgcaagac tcgcaggaga gaaatagagg actttagtca aacaacatca agaaataaaa 2672881 tttaatttat gacttgccta cgttttgcac agcattccaa atatggtttc gaatgttcca 2672941 aacaaacagc aataaccggc tccttccaaa agaaggaata ccggcaagga ttaaagctct 2673001 agctcaccca ttctaagaag ctcaacaacg gcttgcgaac gccctttcac acccaatttc 2673061 tgcatggcat ttgaaatatg gtttcgaacg gttttctcac tgataaatag ctcgcttgca 2673121 atctcctttg ttgtcttatc ttgaacgagc aattcgaaca cttctctttc tcttttcgtt 2673181 agcagcggct tcgattgaaa ttctttctcc ttcaagtatt gtaaccctcc ttgctaaggt 2673241 gagagcgaat cagaaacgaa tgggttttga tatagtcgag atatcatatg taagaagggc 2673301 gcaggaggtg acgtttacaa gataattagt ttatcgtgta tgaagaagcg tttctttctc 2673361 ctcatccgtc cagctgacag ccttgccgct ttcctttgag acttgaacca tcacgactgc 2673421 cccggtgaag cagggttcgc cttcgaggtt ctctccgaga tagtgcaagg taagagatga 2673481 actgccgact gcgcttgttt tcacatagat gcgcaactct tcataaggca tgacttggcg 2673541 caaataatcg cattgctggc ttgccacgac tgtcatggtc tgtttgtttt cactcatcat 2673601 attcagcttt ttaaaataag aaatccgcac ctcctcaaaa tatataaaag gggttacatt 2673661 attcatatgc ccaaacatgt ctgtctcgga aaatcttacg gataccttat tgaaaaaaga 2673721 aaaggatgtt ttccattctt gaaacggcat atcaatataa gcgggaagct tcatcttttt 2673781 tcatctcctt attgtttaaa aaaacctctc ccatgcggaa gaggtttttt cttcttatac 2673841 tctgtcgctt ccgaagaaat tgcggaacgc ttgtaagttt gtatctctat tcaaggctgc 2673901 aatcgaagtg gtaagcggaa tccccttcgg acaggattga acacagtttt gcgagttgcc 2673961 gcaatctgca aggccgcctt catccattaa tgcttctaat cgttcagatt tattcatggc 2674021 gcctgtcgga tgcgcgttaa acaggcggac ttgcgacatc ggtgcaggcc ccatgaactt 2674081 cgatttgctg ttcacattcg ggcaagcttc gaggcagacg ccgcatgtca tgcattttga 2674141 taattcatat gcccattgac gacgtttttc cggcattctc ggccccggtc ctaaatcgta 2674201 cgtaccgtca atcggtatcc acgcttttac ttttttcaat gaatcaaaca ttctgctgcg 2674261 atcaacctgc aaatcacgaa cgactgggaa tgttttcatt ggttttaaac ggattggctg 2674321 ttcaagctgg tcaataagcg ccgtacaaga ctggcggggt tttccgttta taaccattga 2674381 acatgcgccg catacttcct caagacagtt catatcccat gtgacagggg ttgtcttctc 2674441 acctttgaca ttaaccggat tccggcggat ttccatcaga gcggaaatga cgttcagatt 2674501 cgggcggtat ggaatctcaa attcttcatc ataaggcgtg ctgtcagctg tatcttgacg 2674561 tgtgataata aatcgtatgg ttttttgttc actcatgatt atttcgccac cttcttcttc 2674621 gagtaatccc gtttccgagg cgttatcagt gatacatcga catcctgata ctcaaattcc 2674681 ggcgcttcat acgggcttac atgtttagcc attgttgttt tgagccattc atcatcatta 2674741 cgttcaggat aatccggttt ataatgggcg ccccggcttt cattacggtt gtatgcgcca 2674801 agggtaatca ccctcgcaag ctgaagcatg ttcgagaact ggcgtgtgaa catcgctccc 2674861 tggttgctcc attttgtcgt gtcattgatg ttgatctttt tgaagcgctc cattaactcc 2674921 tgaattttgt catccgtttt caaaagcttg tcattatggc ggacaaccgt tacgttcgcc 2674981 gtcatccact caccgagctc tttgtgaaga acataggcat tttcggttcc gtccatactc 2675041 ataatatcag cccatttttc ttcttctttc ttaacgtgag cgtcgaataa agatgaagac 2675101 atgtcttccg ctgaagattc taagccgttt acatatttca ccgcattcgg accggccacc 2675161 atgcctccgt aaatcgcaga cagcagggag ttcgctccca agcggttgcc gccgtgcata 2675221 gaataatcac attccccagc cgcaaacagt ccagggatat ttgtcatttg atcgtaatcc 2675281 acccataaac cgcccataga ataatggacc gccgggaaga ttttcattgg aagcttacgc 2675341 gggtcgtctc ccatgaattt ctcataaatc tcaatgatgc cgccaagctt aatatcaagc 2675401 tctttcggat ctttatgaga cagatcgaga tataccatgt tttcaccgtt aataccgagc 2675461 ttctggttca cacacacatc aaatatttcg cgtgtcgcaa tatcacgcgg caccaggttt 2675521 ccgtatgccg gatatttttc ctccaggaaa taccatggtt tgccgtcttt atatgtccac 2675581 acgcgcccgc cttcaccacg cgctgattca ctcatcagtc ttagtttgtc atcgcccggt 2675641 atggctgtcg ggtggatttg aatgaattct ccgtttgcat aatacgctcc ctgctgataa 2675701 acgattgacg cagcagatcc tgtattaatc atggagttcg ttgattttcc aaagatgatt 2675761 cccggtccgc ccgtcgccat aatgacagcg tctgaacgga aggattcaat ttgcatgttt 2675821 gtcaggtttt gtgcaacaat tccgcggcag gttctgtcat catctaaaac agcgccaagg 2675881 aattcccagc cttcgtattt tgtgaccaga cccgcaactt cgtatctgcg cacttgctcg 2675941 tccagtgcgt aaagcagctg ctgtcccgtc gtcgcaccag cataagcagt tctgtggtgc 2676001 tgtgtacccc cgaatcggcg gaaatcaagc aggccttcag gcgtccggtt aaacatgacg 2676061 cccatccggt ctaataagtg gatgatcgaa ggcgccgctt cacacatcgc cttgaccggc 2676121 ggctggttgg caagaaagtc tcccccgtat accgtgtcat caaaatgttc ccacggagag 2676181 tcaccttccc cttttgtatt gaccgctccg tttatgccgc cttgcgcaca aactgaatga 2676241 gaacgtttga caggaacgat ggaaaacaat ttaaccgcca ttcctgattc cgctgcttta 2676301 attgtcgcca tgaggccggc aagacccccg ccgactacga taatgcttga ttgactcatg 2676361 atagcccctc tccctctagt aatctagtac tcttaaacaa atgcaaaaat cgcttttaag 2676421 cctacgtatg acagtgcaac aaaaataatc agcgtaacgt atgtcgaaat tctttgagaa 2676481 cgaggcgtta ccgtgatgcc ccatgtaaca gcgaaagacc ataaaccgtt cgagaagtgg 2676541 aaaattgttg ataaaacacc gacaatgtaa aaaccaagca tagccggaga gctcaaaata 2676601 ttcgccatca tgtcgaaatt gacctcagca cccatttgtg cggcaatgcg ggtttcccac 2676661 acgtgccagc tgacgaaaat gagggtgatg ataccggtta cacgctgcag gacgaatagc 2676721 cagtttctca tgtagctgta ttgaccggcg ttatttttcg cagtaaacgc tatgtacaca 2676781 ccataaactg catgataaat taatggtaag aagataataa aaatttccaa ggcatacctg 2676841 aaaggcaggc tatccataaa atgagcagcg ctattgaatg cttcagcgcc ccttgcggca 2676901 aactggttga cgactaaatg ctgaataaga aagatgccga ccggtatgac gccaagcaag 2676961 gaatgcaatc ttcgaaaata aaactctctg ttcccagaca ttactttacc ccctgtttga 2677021 taagtgcgaa atgtgctaaa tctcttcccc cacttctttc aattgtaagc actttattaa 2677081 gatttattga caatttcatt ttactcctcc ctcaaaaggg cgtcaagaaa acgcgtacat 2677141 aaattataat tttccgaatt gattagttga ttgaaaaatt ttattttatc aatatatatt 2677201 tcttgcttaa tttttcataa gaattacagg atcattctgt aatcctcccc cctgtttgag 2677261 ctataatata cgcaggagag aggggagaca gatatgaagt ctaaatttga agcatctatt 2677321 gacaacctaa aagaaattga aatgaacgct tatgcctacg aactaatacg agagatcgtt 2677381 ctcccagata tgcttggcca agattactct tccatgatgt attgggcagg aaaacatctc 2677441 gcccgtaagt ttcctcttga atcatgggag gaatttccgg ccttctttga agaagcgggc 2677501 tggggaaccc tcaccaacgt aagcgctaaa aaacaggagc ttgaatttga acttgaaggg 2677561 ccgatcattt ccaaccggct taagcatcag aaagaacctt gctttcagct ggaggctggt 2677621 tttatcgctg aacaaattca attgatgaat gatcagattg ccgaatcata tgaacaagtg 2677681 aaaaagagag ccgataaagt ggttctgact gtgaaatggg atatgaaaga cccagtgtaa 2677741 tcaaaaaggc ggtgactgca tagtcccgcc tttttgattg tcattacaca gctgaagggt 2677801 gttttgaaag ctcaaatgca tcgtgaagcg actcgactgc tttcaccatg tcattttcgc 2677861 ttacgactgt tgacactttg atttcagatg tgctgaccat tttgattaaa atgttttttt 2677921 gcgccagtac agcaaacatt tcagccgcta caccgggatt tgagaccatg ccggatccaa 2677981 caatagatac tttagccaat ttgctttctg tctcgatttt ctcaaattcc agcgcgtctt 2678041 tatactcttc aagcaccgca acggtttggt ctgcatcttc tgttttgaca gagaaggaaa 2678101 ttccagtctt gtcctcggcc tgcgtttgga taatgatatc cacgtttatg tttcttttgg 2678161 caagtgttgt aaaaatagta gacaaagttg tcaggccgct agtcagcccg taaatggtta 2678221 ctcttgtgat ttgatcttca aatgcaatgc ctctgacaat taaattctgt tccatggatg 2678281 attcctcctc aattaatgtt cccgcttcgg tttctgtact tgaacgcact tctaacggca 2678341 cttggtaatt tttcgcgaac tcaactgctc tcggatgaag aacaccggcg cctaaattgg 2678401 caagctcaag catttcatcg tatgagatgc cctcaagttt tctcgctgat ttcacatagc 2678461 gcggatcggt tgtaaacacg cctggcacgt ctgtgtatat gtcacattta tcagctttta 2678521 aagcggcagc caaagcaact gctgttgtat ctgaaccgcc ccggcccaat gtcgtaattt 2678581 cacaatcctc tgtcatgcct tggaatcctg caacaatgac aatttttcct ttttcaagct 2678641 ggtctgctaa aaccgaagtg tcgatatctg taattctggc gtttccgtga atggcctccg 2678701 tacggattcc cgcctgccag ccagtataag acacagcgtc atagcctttt tcctgcaatg 2678761 ccattgaaag gagtgaaatc gtgacctgct cgcctgtcgc cagcagcata tccatttcgc 2678821 gtttgctcgg ctggtcagaa atagcttttg caaggctgac caattcgtca gtggattttc 2678881 ccattgctga aacgacgaca acgacttgat ggcctttctg tttttctgca attgcgcggt 2678941 ttgccgcatt ttgaattttt tcgactgagc cgacggaagt gcctccgaat ttttgtacaa 2679001 taagacccat gtattaccac cctttacatt ttggttcgtg cgggtgagga gaaagagcgc 2679061 tttgtccaca ataaaaaaag caatgagagg aatactctca ttgcttatca attaatcatc 2679121 ataaatgatt atgaacaacg agatagccct ccaagaaaat gatttcttga cagccttaca 2679181 tttattcaat gcacggccag caaataatac cgatggggtt ttatttgctt cggcgacgct 2679241 cccctttcag cctttttcac agaatccatc tttctccaaa ggcatactct tgaagttcgc 2679301 acctctatct tcaccatata acacgatcta actatgaaat tagttcacat tttatcagat 2679361 cttatttaaa aggacaacat tatttttgca atttgtcgta aaggagctga gccgccgctg 2679421 cgggaacacc ggcttttttg atgtcctcaa ggcttgcttc cttcattttt ttaacggaac 2679481 cgaaatgctt taacagcatt ttctttcttt tctctccgat acccgggatg tcgtccaaaa 2679541 cggattgaaa cgcgcttttt ccccggattt gcctgtgaaa actgattgca aaacggtgca 2679601 cctcgtcctg aatgcgctgc aggaggtaaa attcctggct gtttcgttcc agatacgcca 2679661 cctccagcgg atcaccgatc agtaaatttg aggttctgtg tttttcatct ttcgctaaac 2679721 cggcgatcgg gatatccaag ccgagttcat tttcaatgac atcccttgct gcgttgatct 2679781 gcccttttcc tccgtcaatg ataatcagat cgggcagcgg cagattctca cgaagcactc 2679841 tcgtatagcg tcttctgaca acctctctca tagaaccgta atcatccggc cctgtaacag 2679901 ttttgatttt atatttgcgg tattcctttt tgtatggttt gccatcgata aacacaatca 2679961 tcgcggaaac cgggtttgtc ccctgtatat ttgagttatc aaacgcttca attctgtgcg 2680021 gcgtataaat atttaatgcc tcacctagtt tctgcactgc cccgattgaa cgctcctcgt 2680081 cccgttcgat taaagagaat ttttctttca atgcgatttt cgcattttta tgggcaagca 2680141 tgagcagttc ttttttcggg ccttttttcg gctggtgaac gtttgtttcc agtagctgct 2680201 cgatcataga ttgatctatg ctgtccggaa ctaaaatctc cttcggaagg aagtggttgt 2680261 tttttgaata gaactgcccg atgaacgtga ggaactcttc atctgcttcc tgataaagcg 2680321 ggaacatgct gacatcgcgt tcaatgagct ttccttggcg gatgaaaaag acctgcacgc 2680381 acatccagcc cttatcgtac gcgtacgcga acacatcacg gtcgactaga tcgttcatcg 2680441 tcattttttg tttttccatc gttgattcaa tatgggcaat ttggtcacga agctcttttg 2680501 ctcgttcaaa ctcaagattc tcagcagctt catgcatttt ctcttcaagc tcttttttga 2680561 cctcattata gccgcccctt aagaaacgtg taatgctttc aaccagctct ctgttcgtct 2680621 cttcggaaat atcctttaca cacggagcaa ggcattggcc cagatgatag taaaggcaca 2680681 ctctgtccgg gagcttggag cattttctga gaggatacag acggtcgagc agtttttttg 2680741 tttcccttgc tgcctgtaca ttcggatacg gcccgaaata gcgccctttg tcttttttga 2680801 cattgcgggt gacaatcagc cttgggtggc gttcatgggt gagttttatg aaaggatagg 2680861 ttttgtcgtc tttgagcatg acgttgtatt tcggatcatg ctttttgatc agattcattt 2680921 ctaaaataag cgcttcaaga ttggaggacg tcacaatata ttcaaaatcc tcgatttccg 2680981 tcacaagcct ttgggttttc gcgtcgtgag aaccggtgaa gtaggagcgc actctgtttt 2681041 tcagcacttt tgctttccct acgtagatca cagtctgctg ccggtccttc atgagataac 2681101 aacccggttg atcaggaagg agggcgagtt tttctttcag ttgtttgttc atatgttacc 2681161 cttccttatg tttaatcctt tatttccagt ttaacacgaa cgtttgtttt tctctatggt 2681221 tcacaattgg cgaataaaaa aagcgatccc tcaatcggaa tcgctctggc atgtaagcag 2681281 cggaaaatta aagatgtttg tttacaagct cttgaagcgc ttcttttggt ttgaagccga 2681341 ctgaagtttc aactacttcg ccgtctttta acacaagaag agtcgggatg ctcataacgc 2681401 cgtattttcc ggcagtttct tggttttcgt ctacatcgat ttttacgatt ttcagtttgt 2681461 ctcccatttc ttgatccaat tcttcaagaa caggtgcaat cattttacaa ggtccgcacc 2681521 aaggagccca gaagtctgcc agtacgacgc cttcgcttgt ttcagctgag aaagattgat 2681581 cagttgcttt tacgatagcc attattgaat tcctccaatg tgaaatgatg atttttagta 2681641 tagcatctcc cattcgttca cgctatttta atgcttacaa attatttttt cctgatcaca 2681701 gccggtttac tcatttttat atggttgaat gggatatgct ctttttttaa aacacaaatc 2681761 tgataatggc cccgatcact acaattgccc caataatcat taaaatggta cgaagcataa 2681821 gatcacatct cctcttcact gtcatgtact ttaccatgcc ctgccggagc tgttttaaaa 2681881 cctgaaaaag agcgccggca tgaagctccg gcgctcttgc gcgattaaga atcagcacgc 2681941 agcgtaagta agacgactga cattggcggg agttttactt tcagtttgtt tttgctgagc 2682001 gtgtattgtc tgaaggattc cggtttgaca tgatgaggat cgtcaaacgt gttatgcgca 2682061 ttcatttttt ctgccgtaag aatgactccg gaatggtccg ctgccttgtg taggcccctc 2682121 agctcgattt ccgcctctgc tttgttttgg tgatcgatgt tgcaaattgt gatattgata 2682181 tcgccttcag cttgtttcga cgctgaaatg ctgatttgcg gaagcgtttc accgttccat 2682241 tcatagtcgg cagacattgt ctctgtggct aaaagagaag cgtcctggtg caccttaaac 2682301 atattgaata catggtacgt cggtgtcaaa agcatccgct ctccctcagt caaaatcatc 2682361 gcttgaagaa catttactgt ttgggcgatg ttggccattt gcacccggcg gcaatgctga 2682421 tggaaaatgt ggaaatgaga agccgccacc agtgcatcac gaatggtgtt ttgctgatat 2682481 aagaaaccgg gattcgtgcc tggctcggga tcaaaccacg tgccccattc atcaataatc 2682541 agcccgaccc gctgctccgg atcgtaccgg tccataatcg tgccgtgttt ttgaatcaat 2682601 tcatcgatgt atttggcttt tttcatcgta ataaaccatt catcttccgt gaattctgtg 2682661 gctgatcctt tgcccttcca gaaatccccc ggaatcgtgt aataatgaag actcaacccg 2682721 tccatcaggc cagcggcttt tttcataagc acgtccgtcc aattaaaatc atccacattt 2682781 gcgccgcctg caattttata aatgtcattc ccgctgtaat tgcggacata agtctgaaaa 2682841 cgccggtaca gatctgcgta gtattcggga tgcatgttgc cgccgcagcc ccagttttca 2682901 ttgcccacgc cgaaatattt cagcttccaa ggctcttctc ttccattttg ctttctccag 2682961 tctgacatcg gcgtgccttc ttcaaatgtc atatactcaa tccactccga catttcctga 2683021 acggttccgc ttccgacatt gccgcaaata tatggctcgc attcaagcag ctcgcaaagc 2683081 atcataaatt catgcgttcc gaattcattt gattcaattg taccgcccca gtgagtgttc 2683141 agcattgtct tacggtcacc gacaccgttt gcccaatggt attcgtccgc aaaacacccg 2683201 cccggccacc taaggacagg aatgtgcagc tgtttgagcg cctccagcac gtcctttcgt 2683261 atcccgttga tattggggat gtctgagtcc gttccgaccc agatcccctc ataaatccct 2683321 cttcctaaat gctcagcaaa atgaccgtat atatttttgt taatggttcc ttttgcgata 2683381 tctgtttgaa tcactgcttg atgttcagac atgcctctga tcattccttt catacggata 2683441 tgaaaagcac cacagtcaaa tatgtgatct gtcgtttgcc tgaggagtca gcatgaatgt 2683501 aagcgctttt aaagtaacca tattatatat gttcgtacat gtcaacgaca ttttctattg 2683561 tttttatatt tgtacgtatg tatttataaa tatgaaaaaa cccggacttt taaagtccgg 2683621 gatttccttt atgagtgtat attcagctgt ttgaattcct cagttaataa cgggacaact 2683681 tcaaataaat caccgacgat gccgtaatcc gctattttaa agatatcggc ttcggggtct 2683741 ttattgatgg cgacgatcac cttgctgttt gacatgccgg ccaaatgctg gatggcgccg 2683801 gaaatgccgc atgcaatgta caaatccgga gtaacgactt tcccggtctg cccgatttgg 2683861 agagcataat cgcaataatc agcgtcacat gccccgcgag aagccccgac tgcggcccct 2683921 agcacctctg caagctcctg cagcggctga aatccttcct tgcttttgac tcctcggccg 2683981 cccgcaacga taattttcgc ttcggagaga tcaacaccgt ccgccgtttt tttcacgacc 2684041 tcttggataa cagtgcggag gtcagtaaga gaaacatcaa tgctttcgat gctccccgat 2684101 ctgctggtgt ctttttctga agcttgaatg ttattggggc gaattgttgc aaagatcatc 2684161 ggatcggttg aaatgacgcg ttcaaaagct ttccccgagt aaatcggccg tgtgaacaca 2684221 acattccctc cggtaacgct tacatctata gcatcagaaa ttaagcctgt ttgcagacgg 2684281 gcagcaagct tcggtgaaag atccttgccc attgccgtat gcccgaagat gactgaatca 2684341 ggattttctt gctcgataac acctctcatg acctggctgt acccgtctgc cgtgtatgtt 2684401 ttcagcttcg ggtcctcagc ggtaagaact ttatctgctc cgtaatgaat aagctcttgt 2684461 gcaatgcttt gtacattttc accgatgaga acaccgatga cttccccatc tcctgaaatg 2684521 gttcttcctg cagctattgc ttcaaaggtg acatttcgca attccccatc gcgtatttct 2684581 ccaagcacga tcactttttt tcccattcta acatccccct gtttctttga atgtccaagt 2684641 tttaaatgac tttagcttcg ctgcggagca atgaaacaag ctcttttgcc tgttcagcag 2684701 gctcaccttg gagaagcttc ccggcttctt ttttcggcgg cagaaaacgt tcaatggttt 2684761 tcagctttgg ttcagcatcc tcttcgtcca gatcaagatc atcaagttca agctcttcaa 2684821 gcggcttttt cttagccttc ataattcccg gaagcgatgg atagcgcggc tcgtttaagc 2684881 cctgctgagc tgtgacaagc aatgggagcg tcgttttgat tttttcaaca tccccttcga 2684941 cgtccctttc tgcttctgca tcagtgccgt tgatttcgag tttggtgatc gtagtgatac 2685001 acggaatgtc cagtagctcg gcaagccgag gcgccacttg tcctgatcct ccgtcaatgg 2685061 caacatttcc gccgagaatc aaatcaaact cctgatcctt catatagtgg tataaaactt 2685121 gagaaatgga atattggtcg ggttcatcaa gatcatcttc tatgttgatt aaaacagctt 2685181 ggtcacaacc catggcaagc gccgtacgca attctttctc cgcttcttca ccgccgaccg 2685241 tgacagcggt gatcgtgccg ccatgctttt ccttcagctg gatggcttct tctatcgcgt 2685301 actcatcata tggattaatg atccattccg ctccgtcatc ctgaatcttt cctgtttcaa 2685361 tgacgatttt ttcttctgtg tcaaacgtcc gtttcatcag tacaaataga ttcatgatca 2685421 tatccccttt tattcgcctt tgaactgagg ctttcttttt tcgagaaatg cctggatgcc 2685481 ttccttggcg tcctctgact caaatgcttc cccaaatcgc tttgcttcaa gctttaagct 2685541 gccttcatag gaatacacct tgttggaata aagaagttca agcaaagatg ccagcgtttg 2685601 cgggcttttc tctgcaaact tagcggcaag tgcttttgct ttttcaatca cttctgcctc 2685661 atctttcgct ccaattgaga caagtccgag atcaagcgct tcttttccgg atatcggttc 2685721 tcctgatccg atgagctcca gtgctttggc tgtaccgaca tatctcggaa ggcgctgtgt 2685781 ccccgcaaaa cctggaatga taccgagatt aagctccggg agccccagct tagcatcttc 2685841 tgccgcgatt ctgatgtgac aggccattgc aagctccagc ccgcctccga gagcagcgcc 2685901 gtgaatcgct gcgataatcg gttttggaaa actttcgatt ctctccatta actgctggcc 2685961 gcgctcagcg agcaatgagg aatcctcatt gcctttaagc gatgtaaatt ctttaatatc 2686021 agcgccggct gagaaaaatc ttccctcgcc gtgaatgata atgcttcgta cgcctgcatc 2686081 tgtctcacat tgatcaagac aggaagacag ctcttctaat atccggcttg aaagcgcgtt 2686141 tgccggcgga ttgtgaatcg tcaagactgc cacaaattga tcaaccgcaa gtgaaattgc 2686201 attcatagga cagaactcct ttacttattg tgaattccgg ataccaataa ttctaaaacg 2686261 ctgtttgaaa gcgcaacgag atcgtacttt tggtcattca tcacccaagt tgtcacagtt 2686321 tcgtcaatcg ttccaaaaat catctgccgg gcgaggcgga catcgaggcc ttcttttatt 2686381 tcgcctgatt gtataccttc cgtcaaaatg ccatccaaaa tatttaagta gccttttaat 2686441 atttcgttga ttttttggcg cagctccaag ttggattggc ggagctcaag ctgcgtgaca 2686501 atggcgagat tatggtcacc cgctaaaagg gaaaaatgct ttgaaatcac aagcgccaat 2686561 ttctctttcg ctgttgcttt ttctttaatg tcctcttcca tccgctcaat aaattgaccc 2686621 attttttctt tgaaaagaga aattaaaata tcttctttgt ttttaaaata gagatagatg 2686681 gtgccgtccg ctaccccggc ttgtttggca attttggata cctgtgactg gtggtagccg 2686741 ttttctgcaa tgacttctac tgctgcatca ataatctgca tatactttgg ccgtttttgc 2686801 ttcaatgttc atcgttcctt cctatagaaa tgaatgacta ttcattcata atttcatgat 2686861 aagaaggatt ttcaggtttg tcaagtttat tcataggcgt tctctttttt tatttgatat 2686921 gatgattttc ggtttcttct tcaagtaaac gccttcttaa aatttttccc accgccgttt 2686981 tcggcagctc ctttctgaac tcataggctt tgggcacctt atagggagct agacgtgatc 2687041 tcgcaaaagc gtccagttct tctgtatcgg cttttgcgcc tttctttaat acgacaaatg 2687101 cttttactgt ttctcccctg taggaatcgg gaacgcctgc gacaacaatt tcctggatgg 2687161 cttcatgttc ataaagcgct tcttctacct cacgcgggta aatattgtaa ccgccggcaa 2687221 tgatgatatc cttcttcctg tcagcaatat agaaaaagcc ttcttcatcc atatagccca 2687281 tgtccccggt gaacagccag ccatctctca gcactgcggc ggtttcctct ggtttattcc 2687341 agtatccttt catgacttgc ggacctttta caatgatttc tccatgctca tacggagcgg 2687401 caagctcacc cgtctcttca gaatagatcg cagcgtccgt actcggccaa ggacagccga 2687461 tactgcccgg cttgtttttt ccccagataa agttggcgtg cgtcactggg gatgcctcag 2687521 acaaaccata gccttccaca agctttccac cagtcacctt ttcaaatttc tgctttacct 2687581 ccacggggag cgcggctgat ccgctaagac agcttttaat ggatgacaga tcataatgct 2687641 gcaattcagg gtgatgcaaa aggccaatgt aaattgtcgg tgcgccagga aagagcgtcg 2687701 gtttgtgttt gtcgatgatt ttaagtgttt cgagcggatc aaacttagga agaagaatca 2687761 tttcgaagcc tagtttaatc gaatagttca tgactgccgt cagtccgtag acatgaaaaa 2687821 atggaacgat gcccagcact ttttcagcgc cttctttcac gtcatacatc caagcggcgc 2687881 acatttcagt atttgccaaa atattttggt gcgtgagcat gacccctttt ggagctccgg 2687941 ttgttcctcc ggtatactgg aggacagcga tatcatgctc aggatcgatc ttcgggattg 2688001 tcaggagttc agttttttcc tgcttcatac aggaagcgaa cgtgtgaatg ttagctgttt 2688061 tgtcaaagtc gatatgcact ttttgttttt gcgtcagcgg gtaaagaata tttttcggaa 2688121 aaggcaaata gtcttttaca ctggttatca aaatctggtc gactattgat aacgttttca 2688181 tttttattgc cttcgggaaa agcaaatcta aggtgatgat tacacttacc tgagcatctc 2688241 taagctggta ttcaagctca tgctcggtat aaagcggatt cgtctgcacc acgatgccac 2688301 cggcaaacaa gacgccataa taagaaatca ctgtttgcgg gcaattgggc agcataacag 2688361 ccactctgtc tcctttttgc aggccattgc actgcaaaaa agctgcaagt ttaagagcat 2688421 ccgtcagaat gtcatgaaag gtgagttttt ttccataaaa cgatattgcg gttttatcag 2688481 ggaatcgtgc ggcggagtct gtcaggatgg attgcagggt tttattcggc aacggaagct 2688541 catgcgggat atcgttggga tactcggcaa gccacggctt ttgagactgc ataaaacctc 2688601 ccctttcgat tttagagatc caccttatca ttatagcaga tggacggcaa aaaaaagaaa 2688661 aagaaaggta aatctttctt tttctcataa tatgaacaga tatataagac caattaacaa 2688721 aaagattccc gctgcggcga gcagtatttt cgcaagcttt tccatctatt ctccgtcccc 2688781 ttatattccg gctgccacca caaaagaaag cccgacagaa atgacaaatg aaataaagcc 2688841 gacagcccgg ttatcatttt cgatttcctg atcaatttta aaccgcggag tcaaaaactc 2688901 aaaaataaag tagctgatca gaagcataac aaacccgtaa acgccccagc cgatcatttg 2688961 cagcagcgaa ttatgctggg agatggaatg ctgaaatacg tttgcgattc ccaaaatttt 2689021 tccgccggtc gccattgcca ccgcaagatt tcctttttga atctcttccc agtttttata 2689081 agccgtcacc agctcaaaca cagtcaaaaa gaggacgagg cagagaaccg cgacactgta 2689141 atatgccgcg atttccacaa gctcgttttc ccaaaaatca ctcatggcca tactcccttt 2689201 tattttagtt caacaaccgt aacgcctgat cctccctcac ctgcttcacc gaaacgggaa 2689261 cttttgacgc tgcggtggtt tttcagaaga tcctgtacgc cttttcttaa agcgccggtt 2689321 ccttttccgt ggatgattga cactcttgga tatccggcta acaccgcatc atccaagtat 2689381 ttttcaaccc ggctgagggc attttcatag cgttcgccgc gaagatcaag ttcaagcgat 2689441 acgtgatagt cctttccttt gaccgctgta atcatttttt ctttttttgg ctccggagct 2689501 gatttgataa actccagatc tttttctttt actttcatct ttaaaatacc gatttgaacg 2689561 ttccattcat tgccgcctgt tttttcgagc aatgttcctt tttgcccgaa agtgaggact 2689621 ttcacctcgt cgccaggctt aaagtcgcgt ttttgcgttt tcggcttttc cggtttcttg 2689681 gacttttcaa aagcaggcat agcgccttct aaccgtttct tcgcgttaat cagctcgtga 2689741 tccttgaagg atttgtgttc ttcttttatg gtgcgcaatt catgaataat gtcctcggct 2689801 tctttcattg ccgcttttac tttttcagca gcctgctgtt ctgcctcttc aagcattttg 2689861 tcttttttgc tgttaagctc gatgatttgc tgctgcagct ctttatgcag tttttccgct 2689921 tcttttctga ttgattctgt ctcagaaagc tcttcttccg cacgtttttt gctttgttcc 2689981 agcgacgcaa tcatcgtatc gacttcgtta tgctcggccg tcatttctga cttcgcctgc 2690041 ccgatgatat ggtccgggag cccgaggcgt tttgaaattt cgaaagcatt gcttcgaccc 2690101 ggcacaccaa ttaaaagttt ataggtcggt gacagcgttt cgatgtcaaa ttcaacgctg 2690161 gcattcatga cgccttctct gttatagccg tacgccttca attccggata atgcgtcgta 2690221 gctaacactc gtgcattggt gcgatgcacg tcatccaaga tgctcatggc gagggccgcc 2690281 ccctcctgcg gatctgtccc tgcaccaagt tcatcgaaaa gcacaaggct gttttcattg 2690341 acctgttcta aaatgccgac aatattcacc atatgggatg agaacgtact taaactttgc 2690401 tcaatcgact gttcatcacc gatatcagcg aatacgtgct caaatactgc cgcttctgac 2690461 ccttcatctg ccgggatatg aagacctgac tgcgccatta aggttagcag gcctaacgtt 2690521 ttaagggtga ctgttttccc cccggtgttt ggccctgtga tgacaatggt tgaaaaatcg 2690581 cggccaagct cgatgtcatt ggcaacaacc tgatcaggcg gaagcaatgg atggcgggct 2690641 tttttcaaac ggataaagcc ggtgtcgttc ataatcggtt ttgtcgcttt aaccgctttt 2690701 gcatatctag cttttgcaaa aataaagtca agcgtctgca gcacttgcaa atctagaaat 2690761 agctcctctg tatactctgc cgttttctct gtcagcacac gcaaaatccg ttcaatttct 2690821 tgcttttctt tcactttcgc ctgctgaagg gaattgttca tatctacaat cgcctgcggt 2690881 tcaatgaata gtgtcgcacc agaggatgag gtgtcgtgca caattcctcc atagctggat 2690941 ctgtactcct gtttgaccgg gatcacaaag cggtcattcc gaatcgtaac aatcgtatca 2691001 gacagcattt tcgatgcgga agaggaacgc agcatcgact ctaaccggtc tctgactctt 2691061 gattcgagtg ttctgagctg tgtgcggatt cctcttaatg tttccgatgc atgatcaagc 2691121 acttctccgt gatcatcaat gcaggaatta atgtcccgct ctaaatcgga cagcgtgata 2691181 agctgttcag catgctgatg gatcagcgga atgtcgacac cgtcttcagc catttgcgtg 2691241 ataaaatgtt tcatttgttt aactgcataa agcaggcctg agatttcagt gaattcagaa 2691301 ggactgagaa cgctgccgat ttccgcccgt cttaacgctc ctctgatatc tacaaggccg 2691361 ccaaatggcg cttggcctct cagccggata atgtcagaag cttcgtctac ttcatccagc 2691421 tgttttttga tttcgtctat agaagcagaa ggcttaagct cgagaagcat ttcttttccg 2691481 agcgatgaag cggcatgccc aataacctgt tctttcactt tatgaaattc aagagctgat 2691541 aatacttttt gctgcacgat tgtgtgagcc tccttactta atcgttgcgc ttcagaaatg 2691601 cctctacgtc tttaagcgac cgggcattca gaacgttttt cgtttccgtc catcctttgc 2691661 gcgcggcagt aacgccagtt ttcatatcgt ctaacatctc aatattatgg gcatcagtat 2691721 taatcaccaa tgtaacccct tgttcgtttg ctttcattaa atgctctgtg cgcagatcaa 2691781 ggcgcgcagg gttggcattg agttcaagcg ccgtatttgt tttcctcgca agctcaatca 2691841 gctgatcaat atcgatttcg taaccggccc gtctgccgat aaggcgcccg gtcgggtgtg 2691901 cgataatgtc aacatgcttg tttgtcagtg ccgtctcaag ccgtttcata atcacgtgtt 2691961 ccggctgatt aaaactggaa tgaatcgatg caataacgat atccatttcc gcaagcacat 2692021 cgtcatcata atcgagcgta ccgtcaggca ggatatccat ctcaacgcct ttcaaaatac 2692081 ggaagttttc aaactctgca ttcagcgcgt caatttcttt tgcctgctgc ttaagtcttt 2692141 ctgcagtaag cccgttggcg acctttaaat attgtgagtg atcggtgatc gccatgtatt 2692201 gatagccttt tttgatgcag gcttcagcca tctctctgat cgaaaatgcg ccatcgctcc 2692261 acgttgagtg catgtggaga tcacctttga tttgcccgag ctctatcagt tcaatgctgt 2692321 cgctgtaggt ttccacttcc tgtccgcttt cacgaatttc cggcggaatc agcggcaggc 2692381 cgaagtgcgc ataaaattca cgttcactcg gaaatgtttt gatctctccg gtttcaactg 2692441 tctcaacgcc gtattcactg atccgctcgc cgcgttcttt ggcgatttgg cgcatcttaa 2692501 tattgtgatc ctttgatccc gtaaaatgat ggagtgttgt cggaaactgc tcttccgtca 2692561 caagacggaa atcgacgctt gtttcatatt caaaggaaag gatgacggac accttcgtat 2692621 ctccgcttgc gatcacgctt ttgatgtttg gcagctcaag aagctgctct cttacttcag 2692681 ccggatgatc tgtagcaatg atataatcca gatccttcac cgtttcccgc gctctgcgga 2692741 gacttccggc acgagaaaat ttgatgatat gcgtaaattg agaaagatgc tcctcaattt 2692801 cccgcgcgat ccggagggcg tagccgatcg ggaaccgttc aggctgtttt ccggcttccc 2692861 cgagcgcctg taatattttt tcttccgatt ttttgccgaa gcccgcaaga ccctggacct 2692921 tttgctgctc acaggcttcc ttcagagatt ctgcatcgtg tacgccgagc tctttataca 2692981 gctttgcgat ttttttgccg ccgagccccg gcagcttcaa taaaggcacg agtccttccg 2693041 gcacttcttt ctgaagcgat tcgagcgtgc ttgactttcc ttcatctata tactctttaa 2693101 tgacgctgta cgttcctttt ccaatgccgg acagcgacat catatcgtcc atttctgata 2693161 agcttcggtc gtcctgttcc agagctgccg ccgcttttcg gaaggcggat actttaaacg 2693221 ggttgtcccc tttgagttcc atatagactg caatggtttc aagcagccgg ataatatctt 2693281 ttttatgcat atcataaccc ccagacgttc acatatgttt ccatcatact tgaaaaaaac 2693341 ttctccggac aagagaagtt tttttatgcc ccgtactgtg tccacagctc ttgtaaaagc 2693401 cctgacaagt acggtgtatg gttaatgatc acatttgcga gagacgattg ccccatcatt 2693461 tgctgcaacg cgtctaccgg cagaacggat gcgacataca gcagcacaaa tgtaaataaa 2693521 tagacttcta gaaaaccgag aacggctccc agcatctggt tgatttgttt aatcaccgga 2693581 atgccggcta caatactcag gaacgagccg atgattctca gtaagatttt agcaatgata 2693641 aataaaacga taaacgcaat cgcattatag tacgctgctt ccaaattccc cgtaaaaaaa 2693701 gaaagagccg gctgtcccgc tgaaaaatcg ggtgcgggaa tccaatgtaa atgcggtgcc 2693761 acgtttttat agaataaagc cgcaaaggca attgataaaa taaagctcgt caagcggata 2693821 aactgcagga taaaaccgcg ttttaacccc agtaaagtcc ccatcaggag caagattaag 2693881 atgatgatat ctagcatagt tgttcaatcc ttttctttaa gctgacgctc cagtttttca 2693941 catttctctt gtaatttgac ataatcgtgc accacattta ccgctgtcag cactgcaagt 2694001 ttatttatat caaggtatgg atttttttca ttgatttctc tcattttatc atcaacaatt 2694061 ccggcgacat acctcatatg ggctctgctt tcttcaccga caatcgtgaa gtgctggccg 2694121 taaatgtcaa cggttgtttt tgtttttttg ccgtcagaca acgtttctcc tccattccgc 2694181 gagaatccta gttcttatca taacacgttt attaaatgaa tggaaagacg agcctcccgc 2694241 tgttatgata cactggtata tacagcgaaa agtgtaaaaa aaggagatta ttacgtgtcc 2694301 cattcagtga taaaagtatc gttgtctgct attgaccaaa tgaaaatgac gtacagcggt 2694361 tcacttacag cctctgttcc gcagggagcc gtttttcagg caaaaccgcc cggctgtacc 2694421 attacagcat atcaatcagg taaggtcttg tttcaaggaa aaaacgctgc ggcagaatcc 2694481 gcgcgctggg gaacagcaga gcctcaggaa aagaagaaaa cggccaaaaa gccggctgat 2694541 ccccgctatg cccctccggc agatatcgcc ggaatgtctg ttatcggttc tgacgaagtc 2694601 ggaaccggag attactttgg cccaatgacg gttgtatgcg cgtacgtcga caaaaccatg 2694661 cttcctttaa tgaaggaact cggtgttaag gattctaaag atttaaaaga tccgcaaatc 2694721 atcgagattg cccgaaacct gattaaaacc attccgtaca gcctgctggt gttaaagaat 2694781 gaaaagtata acagcatgca ggaaaaaggc atgagccaag ggaaaatgaa agctttgctg 2694841 cacaatcagg cgatcacaca tttattaaga aaattggatg gagtaaagcc tgaagccatt 2694901 ttgattgacc aattcgctga gccaggcgtc tacttcaatc atttaaaggg cagagacatt 2694961 gtgaaggagc ggacctattt tagcacaaaa gctgaaggta ttcacctggc tgtcgccgct 2695021 gcttcaatca ttgcaagata ttcattttta atggaaatgg ataaactatc acgcgcggca 2695081 ggaatgacgc ttccaaaagg ggccggtccg cacgtcgatg aagcggccgc caagctgatc 2695141 ctcaaaaaag gggcatctgc actcagaacc tttacaaaac tccatttcgc caatacgcaa 2695201 aaagcgcagc gccttgctga taaaaaacgt tcatagaaaa aagcttgcag atttctctgc 2695261 aagctttttt atcagcctct taaaacagct tgatatgtgt cttctaacgc tttcagcact 2695321 ttgctgtgcg cctttgtcac ttcttcttca gtcagtgttt gttcaggatt gacatactgg 2695381 agtgagaaag cgactgactt cttgccttcc tccatatgct ctccttcgta tacgtcaaat 2695441 acggttacct ctttcagaag cttgcccccg gcctctttaa tgacgctctc gagctgtccg 2695501 cttgtgacgg ttttatctgt tacaagagcg atatcacgtg tcacagacgg atattttgga 2695561 atcgccgtgt aaacaagcgg tgctgtttct gctgcgagca acgcatgaag atcgagctca 2695621 aatacgtatg tttcctttat atccagttct ttttccaatg aaggatggac ttggccgatg 2695681 aagccgatca gagaaccatt caataaaatg ttcgctgttc tgcccggatg cagctgtttg 2695741 cgttcagact gtacaaattc aatgctgtct aggacgttga gtttgtctaa cagcccttcc 2695801 acaattcctt tgacaacaaa gaaatcaact ggtttctttt caccctgcca tagctgcttg 2695861 cgccataatc cggtaacagc tcctgctacg cgttctgttt caacaggttt tgtgtcctct 2695921 tccttcgtta ggaaaacgga gccaacttcg tacagtgcaa ctgagtcagt ctgcctcgca 2695981 agattgtaag aaacagaatc aagcagattt ggaacaagac tgtgtctgag aatgcttctt 2696041 tcttcactca ttggaagcgc aagcacagta ttcagtgatt tttcaatcgc aaacgctgtc 2696101 gctttcttct cgtttgtcag tgagtaagtg atggcttgtg ataagcctgc gccttcaagg 2696161 aagcgtctga ctttacggcg ttttgcctga tatggcgtta atccgcctgt agttcccgct 2696221 gtctcaggaa gcgtagacgg aatgttatcg tagccgtaca gtcttgccgc ttcttcgatt 2696281 aaatcctctt ctattgtaat gtcaccgcgc cgtgatggga cagtcacaac gagaagatca 2696341 tccgcttcac cgaccgtaaa accgagacgt ttataaatgc tgatcagttc ttctttactg 2696401 atcgtcaggc ctagaacgct gctcactttg tcagcagata cgtgaatgtt atttgcttcg 2696461 attgtcaggt gatcttcctc aaccgttcca gcaagcacct caccgccggc atacagatgg 2696521 atcagctgcg cagcccgttc tgctgcaaga cgtacgcgtg ccggatcaat tcctttttca 2696581 aatcttacgc ttgattcact tctcaaacca aggtctttgg aagccttgcg aaccttctgc 2696641 ccgttgaaat acgcagcctc aagcaaaatg gttttcgtat cttcctgaac ctctgactct 2696701 gctcctccca tgacaccggc aacggcctgc gctttcgttc cgtttgtaat gacaaggtga 2696761 tcggcagaca gcttacgttc ttgatcatca agtgttacga tcatttcatt ctcagctgct 2696821 tttcttacta cgacttcctt agagccaaat ctgtcataat caaacgcatg aagcggctgt 2696881 ccgtattcca acaggacaaa atttgtgatg tcaacgacgt tgttgtgcgg acgaatgcct 2696941 gcattcatca gctttgtctg catccaaagc ggtgacggag caatcgtgac atttttaatg 2697001 atttttgcag tgtacagcgg gttcgcttct tgatcttcaa ttttgactga aatgtaatca 2697061 gacgcttgtt ctgaagcagc cgggtaatcc gtttgcggaa gctttacctc agtgtctaaa 2697121 atcgccgcaa cctcgtaagc aacaccaagc atgttcatgg catccgcgcg gtttggcgtt 2697181 aaacccagct caagaatcgc atcgtcaagc tgtaaagccg ctaaggcatc gcttcctgtt 2697241 tcagcgtcat tcgggaatac gaaaatgcct tctgcatact ccttcgccac aagtttgctt 2697301 tcgataccaa gctcctgtaa ggaacagatc atgccgtttg attcttcacc gcgaagcttg 2697361 gcttttttga ttttgaaatt gcccggcagc accgctccga ctgttgcaac tgcgactttt 2697421 tgtcccttat ccacattcgg cgcgccgcaa atgatttgta caggggcttc agctccgata 2697481 tccacaaggc acttattcag cttatcagca ttcgggtgct gctcgcgctc cagcacatgg 2697541 ccgatgacaa cgcctttgat gccttctcct ttgtattcaa ttccttcaac ctcaataccg 2697601 gctcttgtaa ttttttcagc aagaacagcc gggtccatgc cttttaaatc aacataatcc 2697661 tctaaccatt tataagaaac aaacatcctt gcatcctcct cttacgcctg tttaaactgc 2697721 gaaataaatc tgacatcgtt tgtatagaag tggcggatat catcaatgcc atatttcagc 2697781 atcgcgatgc gctcaacacc cattccgaat gcgaagccct gatattcctt cggatcaaag 2697841 ccagccattt taagcacgtt cgggtgaacc attccggcac cgaggatttc aatccagcct 2697901 gttcctttac atactgagca gccgttccca ccgcatttaa agcatgtcac atccacttct 2697961 actgaaggct cagtaaacgg gaagaagctt gggcggagtc tgatttcacg gtcttgcccg 2698021 aacatttttt tcgcaacaag ttcaagcgtt ccttttaaat cactcatgct gatgtttttg 2698081 tcaacgacaa gcccttcaat ttgcataaat tggtgagagt gcgtcgcatc atcgttatca 2698141 cggcgatata ctttacccgg gcaaatgatt ttaacgggac ctttgccttc atgcttttcc 2698201 atcgtacgtg tttggacagg agaagtttgc gttctcatca aagtttcctc tgtgatgtaa 2698261 aagctgtcct gcatatcgcg cgctgggtgt tctttcggaa gattgagcga ttcgaagttg 2698321 tagtaatccg tttcaacctc tggcccttcc tcgactgtgt agcccatacc gataaataaa 2698381 tcttcaattt cttcaatgac aacagtgagc ggatggcggc cgccgactgc aacagggttc 2698441 cccggcagcg tgacgtcaat tgtctgtcct gcaagcttct gtttcatttc ctcttcttca 2698501 agcttctcgt ttttgtcagc aatcgcattg gcaatacgct cccttacttc gttcgcgagc 2698561 gcccccattt ttggacgttc ctcagcagaa agcttgccca ttccgcgcag cacttctgta 2698621 atcggccctt tttttccgag atattgcacc cgaatatcat tgacaacctt caatgagctt 2698681 gccgcttcta cttgttctaa agcttcttgt tccagctgtt ttagcttttc ttccattttg 2698741 catcctcctt ttatgtaaac aaaccgtcat atgtctttgg aaaataaaaa aaacccgtcc 2698801 cttgtacaag ggacgagttg tggccgcggt accaccctta tttcagacag actgatgctg 2698861 tcgtcagctt cattgacata acggaatcag attccggttc acctttacgc gcagtgtacg 2698921 cggtcccggc gacaactcaa gaggtgaagc caatttccgg ctgcgttaaa aatgctctca 2698981 gtcagcggca ttttctccct ggaaagcagt tgatcagaaa ttgaggtcct ctgtcacggt 2699041 ttttgaaata ttatgttcta ttatagagaa atccaacgct tggcgcaaca ctatcctcgc 2699101 aagtgataca cgaggatggc agccgcaacc gcaacgttta gtgattcagc ctgtccgtaa 2699161 agcggcacgt acaggttcaa atccgttttt tccagcaatg cagcatctac ccctgcacct 2699221 tcatttccta caatgagcgc aaaggattca gactgaggaa tctcctggta aggcgctccg 2699281 ttttgcagcg ccgtgccgta tacttttacg ccctctgcct tcaattcgtc cacatatgaa 2699341 ggcaggtttc ttctcacaac aggaatatgg aagtgagatc cttgagcaga tcgcagtgtt 2699401 tttccgttaa aggcgtccgc cgtgccgtca ccgagtacaa ccgcatccaa accggccgca 2699461 tcagccgttc gaatcattgt gccaaggttt cccggatctt gaacagcgtc aatcagcagc 2699521 accttgcgtg ccgttgccag cttttcttca ggcatatggc acacagcggc aatctgctgc 2699581 ggcgtttcgg tttcagtcac agctgaaaac gcatcttcac tcagcatata gcactggata 2699641 ccagtctcaa gatctgaagg aatcctcgtt tcatccttta caaggatttc tttcacaatg 2699701 cccgggcttt tcaacgcctc ttcaacgagg tgttctccct ctatcagaaa tgtatttgtt 2699761 tttgttcgtt ctttttttgt gtgaagcttt ttccaatcct tcactttttg gttttttgcc 2699821 gattctattt gtttcactgt ctatgtggcg ctcctttttt taacatgatg ttattatatc 2699881 gcaagaacag cacataataa accaggtgca gggttagaat atacgtatta cattttagaa 2699941 aaaggagcgt tttacatgga tcttaattta cgtcatgccg tcattgccaa tgtcaccggc 2700001 aataatcagg agcagcttga gcatacaatc gtagatgcga ttcaaagcgg tgaagaaaaa 2700061 atgcttccag ggctcggcgt tttattcgaa gtcatttggc agcacgcatc cgaaagtgag 2700121 aaaaacgaaa tgctgaaaac gcttgaaggc ggattaaaac ccgccgaata agacatgaaa 2700181 ccgggtgaca gcgcccggtt tttttcttat ataataaaaa catgatgagg gggaacgcca 2700241 tgtttttaca gccgttatta gcgaaaaaaa ttattgctga agttaaaaaa atgtacgaac 2700301 gtgaagtcat tattgtaaac acggacggtc ttattatggc aggcacaaac gatgagcgtg 2700361 tcggacaatt tcatgaggga gcgcttatct gcgcaaaaga aagacgcagc gtgattatta 2700421 caaaagaaga tgaaacaagg ttaaaaggag tgaaagcagg cataaacctc cctgtatttt 2700481 ttgaccatga tgtgattgcc gtcttcgggc tgacaggtga gcctgcagag attcagccat 2700541 tcggagaact gcttcgaaaa atgacagaac tgttcattaa ggaatcgcgg cacttagagc 2700601 aatcccagtg gcgtgagaga atgctggagt cctttatgat cgattggctg caattaaagg 2700661 agtggtctcc cagttttctt gagaaagctc agcttcttgg tgttgacctt tcttcccggc 2700721 gccaaatgat tcttattcag gggtatgagt ggtcacctca tgatattgaa caaatggcac 2700781 gcagctggaa atcctcgtac cctgcggatt tgttcatcag gtggggaaat gaacggattt 2700841 tgattaatca tgaagtgccg cagcatgaac aaagggatcg gcttttgcgg aaaatccttc 2700901 acatttgttc gtttgccaat accgcaagca gccaatatac agcagctggc gccggaaggg 2700961 ctgtcgcaag ctccagcctg acagattcat acgagcaagc ggaaaaagcg ctggctgtca 2701021 gccttaagcg aaaaacgccc atatttgaag aggatctgaa gcttgatatg tgtctgacgg 2701081 agatcagccc gggaacccga aacgaatttc cgcaaagagt attaggaaag gcgctagagc 2701141 atcaggaact tatgaatacg atacggactt tctttcatca cgatttgtct ttgaaacaaa 2701201 ccgctgaaga catgcatata cacatcaata cattgcgtta tcgtctggct aaggctgaac 2701261 agctgacggg attacgtttt gaccgtaccg aggacgtcgt cacgatgtac gtcgcactct 2701321 attttttaga tcaagataca aaatagagag agtttcagtt tcattttttg tatgtttctc 2701381 catggaaggc tttgcttttt ttcttttaca atagattgaa agcgtttttt gacaggggga 2701441 tgggtgaaat gatcaccaag gatgtaaagg agcagctgat tcaggtctcc ggaccagaaa 2701501 actttgatga ctcgaatgcc ggccgtctcg tctattcata tgatgcgacg cctcagtatc 2701561 agtctatgcc tgatgccgtg attgctccga ggaatactga tgaaatatca cgcattttaa 2701621 caatttgcag cgaacatcga gtgccgatcg ttccaagagg atcagggaca aacctgtgcg 2701681 gcggcacgtg cccgactgaa ggcggacttg tgcttctctt taagcacatg aaccagattc 2701741 ttgaaattga tgaagaaaat ttaactgcca cagttcagcc gggcgtcatt acgttggata 2701801 tgatccgggc agttgaaagc aaaggtttat tttatccgcc tgacccgagt tctatgaaaa 2701861 tatcaactat cgggggcaac atcaatgaaa attccggcgg gctacgcgga ttaaaatacg 2701921 gtgtcacccg cgactatgtt attggactgg aggttgttct cgcaaatggt gacatcatcc 2701981 gcaccggcgg aaaactcgca aaggatgtgg ccggatacga tctcacacgt ctttttgtcg 2702041 gctcagaagg aacactcggc attgtgacag aggcaatcgt caaactcgtt ccaaagccgg 2702101 aaacaaagaa gacgctgctt gccctttatg aaaacatcga tgccgctgct caaacggtat 2702161 cggacattat tgccgcaaaa attatacccg ctacgcttga atttctcgat cagcctacac 2702221 tattggtgat tgaggattat gccaaaatcg gacttccgac aagcgcaaaa gcagttctgt 2702281 taattgaaca agacgggcca tttgaaactg ttgaacggga tatggaaaag attgaggcga 2702341 tctgcaaaaa aggcgacgcc gtatccgttc agaccgcaca aacagaggag gaagcgtttg 2702401 ccctgactga agcccggcgt tctgcacttt ctgccctagc ccgcctcaaa ccgacgacga 2702461 ttttagagga tgcgaccgtt cctcgctcag aaatcgccaa tatggttaaa gcgattaatg 2702521 atattgctgc taaatatgat atttccatct gcacctttgg tcatgcggga gacgggaacc 2702581 ttcacccgac atgcacgaca gacataagaa ataaggatga aatggaacgt gtcgaacagg 2702641 cttttgccga gatttttgag aaagcgattg aacttggcgg gacgataacc ggagagcacg 2702701 gagtcgggga aatgaaagcg ccttacttgg aaatgaagct gaaaaaagaa ggcattgatg 2702761 cgatgaaagc gttgaaagcg gcatttgacc cccggaacat attaaatccc ggcaaaatgt 2702821 ttgcgaaaga tgccagaaaa cgtgtggtgg cggaaagatg acaacagaaa aagaaatgaa 2702881 acagatccaa aatgaattta aagagcgtat ggatgaagga gagttattaa attgtatgcg 2702941 ctgcggcttc tgtcttcctt cctgtccgac ctatatcgaa tcgggatttc aggaaacaca 2703001 ctctccgcgt gggcgcatcg ccttaatgaa agccgtagcc gacggtatga ttgaaccgga 2703061 tgaagatgtc gaacggtcgc tgtcactttg cctcggctgc cgcgcctgtg agcctgtatg 2703121 cccgtctggc gtgaaatacg ggcagctgct tgaggaagcc agagatatta tccaccaaaa 2703181 taaaaaacac tctcttggtg aacgtgtcat gcgaaagacg gcttttcacg agctgtttcc 2703241 gcatcaaaac cgcatgcgct cagctgtaag ccttatcggt ttgtatcagc gttcaggact 2703301 gcaaaccgct gtgcgaaaat caggcatgct tcgggtcctg cctgagcatt tgcggacgat 2703361 ggaagctgtt cttcctgatg ttccaaaaag caaagacatg aaacatcggc cgcgtttcct 2703421 gccttccatt ggccccatga aaaaacgggt cgcctttttt tcgggctgct taatggatac 2703481 aatgttttta ccgaccaata acgccacatt gaagctttta cagctggcag gctgcgacat 2703541 tgtcattccg cctgaacagg cttgctgcgg ggcgcttcat ggacacagcg gtgaaaaaaa 2703601 cacagggaaa gagctcgcga aacaaaatat cgctgctttc gaagcattag acgtggatgc 2703661 agtcattaca aacgcaggag gatgcggagc ctttctcact gaatatgatc atttgctgaa 2703721 ggatgaccct gagtggtcgg aacgggctgc cgcttttgtt caaaagctga aggatttttc 2703781 ttctgttttg gttgaactcg atttccatca aatggatcta gcactcgaga cgcctcaggt 2703841 cgttacctac caagattcat gtcatctaag aaatgtgatg catacgtcac tcgagccccg 2703901 ccagcttctt aaaagcatca aaggggcgga attcaaagaa atggagaaag cagacagctg 2703961 ctgcgggtca gcgggaattt acaacatcgt cgaagttgaa atgtctatga aaatactgga 2704021 cagcaaaatg gctgccgtca aagcaaccga agcgatcctc attgtaacag caaatcctgg 2704081 ctgcctgctg cagatgaagc tcggcattga acgcgaagga ctaagcggta aagtcagagc 2704141 cgttcacctg gctgatttgc tattagaagc agccgggcac aaaacatcat gagaaagccc 2704201 aaaacagaca ttgttttggg cttttgtgcg ttattccatc ggactgcaaa tttcgatata 2704261 atgtccatcc ggatcagcga tataggcgac cgtctgcccc catggtttca ctttcggctc 2704321 cccgataatc gatacgcctt gttctctcat ccttttgatg accgcttcta cattttcagt 2704381 aacaaacccg atttcaaatg tgtttgaagc agatgtatcc ggaatgtcca gcgccgtgat 2704441 gtctctggcg ctttcccggg tattaagcgc caatatcgta gaccctgtat caaattcgac 2704501 atacgtgccg tgttcagcac gaatcggcag tcctaaaata tcccggtaaa aaatgaatag 2704561 cccgcttgct gtccgatacg tatagaataa gatatttcat tgatagattc attgccaacc 2704621 cctctcagca ttttcaatag tccttctagc ccggtataga tgcttccatc cttaagctcg 2704681 gatctttcca catctgcgcc cattttttca cagccgccac gataatgatg aagcctaaca 2704741 ccagcatgat gatagataat acgccattca atacactata tcctgctgct tcaggattga 2704801 gatacacatt gcgcaccatc caatagcccg cataattgac agtgacatat aaataggcaa 2704861 gcgggataag gcaagtcaga atgtaccggc gtttatcggc gattttcagc acgatcgtcg 2704921 ctccgataat cagccccact gaagccatca gctgattaga aacgccgaag agcgcccaaa 2704981 tggaaccgat atctcctgaa tacagcaagt acccccacat caaacaggca agcgcgctgg 2705041 caaatacaga gcccggaatc cagtctgttt tcttcagcgg cttatacacc tccccgaaga 2705101 agtcctggat caaataacgg gcgacacgtg tgccggcgtc aatcgctgtt aaaataaaga 2705161 ccgcttcaaa cataatgaca aattggaaaa agtatgaggc caaatggctg aaaaacggca 2705221 ttccggtaaa aatataagtc atccctaccg caagcgtgac ggctccccct gttcttcctt 2705281 ctaagtccaa accgatttcc ccgctcaatt caggcaaatg tacgacattc atgccaagcg 2705341 tacggaaaac ctcaggcgtg ctgttaatcg caaagtaatc agcaggctgt aaagcggtcg 2705401 ctgcaatcag cgccatgata ccgacaagac actcaacaag cattgcgcca aacgcaaccg 2705461 gcttcatatc actccattta ttcagcattt tcggtgtcgt tcctgagccg acaaaggcat 2705521 ggaacccaga gatcgccccg caggcgatgg ttattgagat gaacggccag acaggtcctg 2705581 ccagcaccgg ccctccgcct tttacgaatt ctgtaaacgc agggaacgga atggacggat 2705641 tgacgacaaa cacaccaaca atcaaagcga taaaaacacc gattttcata aagctgctta 2705701 aataatcacg cggagccaga agcagccaaa cgggaagcgc agccgcaaaa aacgcataaa 2705761 caggaagcgc gattgcaagc gttttcgtat ctagcgttaa aaagtcaccg agcgcggtag 2705821 tctgtaccca tggaccgata aagactcctg ccattaaaaa gagaaagccg accgttgaag 2705881 cgagctttaa atttcccgtt ttcttataaa ataagcccac acccatcgca atcggaatcg 2705941 taatccccac cgcaaatgtt ccccatggat tacgttcaag cgcatgcaag acaaccatcg 2706001 acaggcccgc cattgtgatc gtgatgataa acagcatgga cagtcctgta caaaatcctg 2706061 caacagggcc aagctcatcc ttcgccactt ccgacagcga ttttccgttt ttgcgcatcg 2706121 atgcaaacaa caccacaata tcatggacgg ctcccccaat taccgccccg attaacagcc 2706181 acaataatcc cggcaaatag ccaaactgcg ccgccagaat tggtccgacc agcggcccgg 2706241 ccgctgcgat cgcggcaaag tggtggccga acgaaaccca tttatttgta ggcacatagt 2706301 ctttcccatc ctcaagcgca tgagcaggtg ttggcttgtc atcattcact ttgagaacct 2706361 tcaccatcat aaatgttccg tataaacgat aggcaatagc caaaatacac attgatgcta 2706421 tcacaattgt aaccgcattc attttctccc atcccctttt ctgtttttca taaatatatc 2706481 ataatttcat ggtgaaaagc ggtcattttt tcctatacaa aaagccggct ggaatgggcc 2706541 ggctcgtggc agttgaaaga caagccggag agaaatctcc ggctttgcta ttcttatgac 2706601 tgttttttca ggcggatcac attccaggaa agcggcgtga aatgagcagt taagccgttt 2706661 tcgctgacag acgatgatcc gttggaatgc ggaacgacat tttttctgtt atgctggttt 2706721 gttgctttga tatcctgatg ctcaagtacg atgtgctctg cgatttggta ggattcaaag 2706781 cctctgagcg aaatctccgt ctccatctga tcctcagcct tgtttaccgc aaaaatagtg 2706841 agtgtttctt cctcttcaga gtacacaaca gcagcatcaa catatggcac atcagtgaaa 2706901 tcagaacaat cgtacttagg agaagaaata agcggtttca gtgactcgcc ccttccgtaa 2706961 acagaagcat gcatgtatgg atagaaaatc ggctgtctcc atgcttctcc gcctttttcc 2707021 gtcatgatcg gcgcgatgac attaacaagc tgtgcaagac acgcaatttt cacacggtct 2707081 gcgtgctgca gcatcgtaat gagcagagag ccgactaata aggcatcttc aaaattgtaa 2707141 atatcctcta aaatcggacg cgcagtgatc cacggctcga cttttttatc agcctcattt 2707201 gagtggtacc agacgttcca ttcatccaga gagagattga tagttttctt gctgcgtgtt 2707261 tttgctttta catagtcaca ggtcgcagcg actgatttga taaaatgatc caaatccata 2707321 gaacgtgcca agtagtttgg cagattgtta tcccggtttc cgtagtaagt gtgaagagag 2707381 atatagtcga catgctcata cgtatgctca agcaccttcg cttcccaatc gataaaggtc 2707441 ggcataccgc tgtttgagct gccgcaggca acgagttcaa ttgatgggtc aacccacttc 2707501 atgacctttg ctgtctctgc ggcaagccgt ccgtattcat cagctgtttt gtggccgatc 2707561 tgccatggtc catccatttc gtttcctaag caccatgttt tgatgccata cggctgttca 2707621 tagccatgcg atcttcttaa atcactccag taagagcctt tcggatggtt gcaatattca 2707681 acgagattac gggcggcatc tatgcctctt gtgccaaggt tgacggccat attgacctca 2707741 gtgttcacct tttttgccca agataaaaat tcatttgttc ccacttcatt ggtttctgtc 2707801 gtttgccatg ccaagtcaag ccgtctcggg cggttttcga ctggtccgac accgtcctcc 2707861 cagttgtatc cggataaaaa gtttccgccc ggatagcgga tgatgggaac ctgtaattct 2707921 ttgatcagcg actggacatc ttttctaaat ccatcttcat ccgcttcagg gtgatcaggc 2707981 tcgtatatgc cttcatatac cgcacgaccc atatgttcga taaacgagcc ataaatccgt 2708041 ttatctactt caccgatttt atattctttg tctacaatca ttcgcgcttt tttcatcaca 2708101 cgtttcctcc ttcattaacc tttgactccc cctaccgtca ggccggagat aaagtacttt 2708161 tggaaaaaca agaaaatgat aatcaccggc aaaatcgcaa atactgagcc ggatataagc 2708221 atgtcgtaat tatttccata agggctcagc aagctggaca gccctattgg aagcgtaaac 2708281 atttctttcg accgaagcac aatcagcggc cacaagaagt tgttccagct gtttaaggac 2708341 tgaaggataa tcatcgcacc gaaagccggt ttcatcagcg gtgccataat cctgaaaaag 2708401 atgccgaatt ccgtacagcc gtccatcctt gcagagtcca gcagatctct tggaaggcca 2708461 agagcatatt gcctgaaaaa gaaaacagca acaggtgaaa cgataaacgg caatatgaca 2708521 cccgtatatg aatcgatcaa gtgcagtccg acagtaagtt taaacagagg aagcatcatc 2708581 acttccagcg gaaccatcat aataatcagc acaagaacaa agatgatatt tctgccctta 2708641 aaatcataaa ccgcaagccc gtacccgatc atcgaagaaa aaaacagagt gagcacagtc 2708701 gtaaaaagtc cgagtacaag actgttaaaa aaccatttga aataaatgct gccgccatta 2708761 aacagaaatg tgtagttatc aaaactcatc acttttggat caatatcaag attcagcccc 2708821 acacgcaaaa gctcagatga cggctttaat gatcctaaaa gcaaacagaa aatcggaaaa 2708881 agatacaata ggctcagcat cataaaaaac agggtcagcg caattctata aacgctaaac 2708941 tgaggactgt gccgcaacat ttatccctcc cccttaaacg agcctgacag ctttaatgaa 2709001 atcaggctga caacaaggat cacaatcaaa agcacaatgc cgatggccgc tccgtatccc 2709061 atttcattgt aggcaagtcc ctgctgatac aaatatccga caagcgtcag accaatatta 2709121 cccggggaat tattctgcca aaggacgtag ctttcctcaa acatcctgaa gccgccgatg 2709181 atgctgatgg tcagcacata tacggttaca ggcttgagaa acggcagcgt gatgtgcaga 2709241 aattttttca ttgtattcgc gccgtctata tcagcggctt cgtacagctc tttcggcaca 2709301 ttttgcaaac ctgctaaaaa gtaaaggatg ttgattccca tccatctcca tgaagcaagc 2709361 agcaccatca aaaacatgcc ggtatgttca ttgttcatcc agttctgagg tgaaaagccg 2709421 agtttaagta ggatggaatt ggccagagac gtttccattt ctccgaagat cagccgaaaa 2709481 atgatccccg cgacaatggt tgaggtcaat gccgggataa ataatgctga tttaaatata 2709541 tttctaaatt tgaccagctt tgaattcagg aatatggcca gaagcaatgg aacaggaatc 2709601 agcacgatca gcgtccaaaa ggtgtattcc agcgtattcc aaagggcggt atagaacgtc 2709661 gggttgttta gcgctgtata attagacaat ccgacaaagg acacctctcc cggcaaaatt 2709721 ctttggaagc tcatgatgaa gacactaatg atggggtata gaaaaaatac gagaaaggat 2709781 aaaacgaatg gcgctgtaaa cagatagggc gccgcttttt ttgaataaaa cagatctcgc 2709841 cagcctgatt gtttcgcagc tgaaggaacg ggatgaaccg ttcccgtttt cacaggtttc 2709901 atgagaacct ccccgctttc actttttgaa tgggattcta tttctgtttc agttcacctg 2709961 ccgctctgtc caaggcttgt ttaggcgttt tttgctgaga tttaagcgcg tcgaacaata 2710021 cgcttctgtt gacaaggtct gaagccttgg caaaatcctc atgtaaataa attggattga 2710081 tttcatcctt gatatcgagc agcacagaaa aaatgcctgt tccgttttgg aagtaatccg 2710141 tgtatttgtt tttctctttc aattccttgg agctccaaac atcccagcga agcgggtcaa 2710201 agccgagtac gctccagagt tttttatttc cttcttcaga gcccttcgca aaggccaaaa 2710261 actcttttgc taactcaaca tgcttggatt gcttcggtac aacagttgcc gtaccgccca 2710321 aacctgccga gcggtcgccc ccctctttcc atgccgggag cggtctgatg gcaatcttcc 2710381 ctttcagatc aggcatataa tcgataaatc ttcccatata ccaaatcggc atgagaactg 2710441 aagcagctcc tccttggttc ataaagccgt agtattcttc actgtgatgc ccgccgcccg 2710501 gcgcaggaat catcgtttta tcattgatca tgtcttttaa atattgaagt gtttttacgt 2710561 tggtgtcatt attgaggatc agcttgccgt ttttatcaaa atagcctgag ttttgctgtg 2710621 aaatcataga taagaacgtt gcggaatcat ttgtttccac cgttcccatc ggcttcccgg 2710681 tcactttgcg cactttctgt ccggctttat ggtaatcatc ccatgtttta atatcgtcag 2710741 gattgacgcc ggcttttttc atcacatcca tgttataaaa catgaccgtt gtccctacat 2710801 gtgtatcgag tccgtaaagc tttccgtttt tgctgtacaa tgtcagccgc gcctcaacga 2710861 atttatcgcg atccttttca atcagcggag tcaagtcggc aagcggtatg tcagagccct 2710921 tcaaaaagtt tgaaaaacgg gccaattcga catctgcaat atcaggaacg ccttctcccg 2710981 ctattaggga gatagataag ttatcgtgca tttgtccata tggataaacg accgtattca 2711041 gcttaatttt gcggtcagga tattttttgt tccattcctt caccatttcc acatagaact 2711101 gctcatgaag cccgttaaat gtccaaaagg tcagctcagt ttcacccgat ttgccggatg 2711161 atttttctgc tgaacacccg gcaatgacta atgtcagcaa catcatgagc acaagaaaac 2711221 agacagtcat ttttttcatc tgcgttaccc cttccattcg aggtgcgggc tattcatata 2711281 gaccatggtt gatcagcgtt ttgttttcat tgatgattct taatccggtg catcggtctc 2711341 ttaaggtgtg cgcgtgtctg aaggcatttt tgacggaatc ctgcccgaca ccgatttcgt 2711401 caaaatacgc agggcctccg gctgatctca gccaatcagc cagcacttct cctctcggga 2711461 gtgtttgata agccgattgg atggcttccc ggcggcttgg tgaaaattcg ttcagcccgt 2711521 catcctgagc gagctttctg tatgtgtcag ttaataaaac agcggcacag cccacctttg 2711581 ccccatgaag aatctgaggc cgttttttct ccattaactc catttcaatc caatgtgaaa 2711641 tatgatgctc gccgcctgat gccggtcggg aatgatctaa tgccagcatg acaagccccg 2711701 atacaagtaa agactccatc aaaacccgta tgccagtttc cgttttcatc gcaatgtctt 2711761 ctgtgtgttc aatgcaggca gcaagcgcct cctgaacgat cttagctcct gcaggcgaat 2711821 aaggctcacc ggcaagatgc cgggatattt cccaatctgc taaagacgtg attttaccga 2711881 gcatgtcacc aaagccagcc gccaccattg actgcggtgc cgcttttaat agatccagat 2711941 cagcgaacag cgcagatggg gccttcgttt gaatggttgt tttcgtgccg tataaaataa 2712001 tcggcgcacc ggctgatgta aaaccgtcta cagatggagc agtcggataa gaaataaacg 2712061 gcaaatctct ttgaaacgcc gcaaagcgga cgatatcatg aatcgtgccc gaaccgactg 2712121 cgatcatgac atccgttggt tgtttcgtat ggatcagcac atgaatgagc gatcgttcat 2712181 cagctgtcac atctccggct tcattttctg gaatgatcag gcactcggcc tgaaatcctt 2712241 cttgattcag tcggttttct aaatcaattc ctgcaatgcg gtgtgtattc gcgtcgcaga 2712301 caaggacaat atgttgattg ttttttcgtt ttacataatc caaaagcgaa tcagctgctt 2712361 gcttaccgag aacaatttct tcaactttta taggcaacgt cttttctccg gcgttttcaa 2712421 aagcacgctg aacgtcagct gcgatacgat tcatatcaga atcccctcct cagccaattt 2712481 ggttacatcc ttaatagaat ccagcacata atccggcgtg tacaaacgct gttcaccctg 2712541 tttcgcagaa ccagttagca ctaaggcgct tttcatgcca taaagcttcc ccatcgcaat 2712601 gtcagattca atgctgtctc ctataatcat gcattcatgt gcggacagcc ccattgctgt 2712661 acaggcagcc tccgccatca gccatgacgg ttttccgaca acaagttcag tcttcgcttg 2712721 tgcagaagtc tcaattgccc cgatcattcc ggccacatca atggcatttc cgtcttcgtt 2712781 cggaaaagag cggtctttgt ttgtagcgat aatacgagcg ccgccggcag ccgcttgaaa 2712841 ggcttgattt aaatcgtcgt acgtgagcgt ttcatgaagg gagatcacga gccaatccgc 2712901 ttccttcggt tcgctcgcgt tctgcacacc ggccagcctc agctcgtcaa ccaagccttg 2712961 ctccccaagc acccatacct ttgaaaaacg ataatgtttt ttcagaaaag ccgctgtcac 2713021 gcttgatgac agaacaatgt cgtttacgtc cgtttcaatc cccgcgccaa gaagtttttt 2713081 tctgcacatg gcacgggaga tattcccccg gttgcttaaa aagacgattt tctttcccat 2713141 tctcctaagc gttttgatcg cttctcttgc tccttcgatc aactcatttc ctctgaatac 2713201 agtaccgtcc aagtcaatca gaatgccagc cggtgacaca ggcgtatcat gactggccat 2713261 aatacgcatt tgctccgtgt tttcgataaa aatgcttttc atgcaggact gtattgattg 2713321 gggttacatc cttgttcagc ataatggagt gataggccat ttcggcaacc gtttctaata 2713381 caactgcgtt atgaatggca tttaaggcgt cagtgcccca gcagaacggt ccgtgattat 2713441 tcacgagcac acccggcacc tgttcgtaat tatgatgctg aaaggtttcc gctatgactt 2713501 ttcctgtatt cagttcgtag tcatgaatga tttcttcatc gtacatttct cgagtacatg 2713561 gaatcgcact gtcaaaataa tcagcatggg tcgtgcctaa cggagggatg tctctgcccg 2713621 attgcgccca gcttgtcgcc cattgagaat gggtatggac aattcccccg atattcggaa 2713681 aggctttata tagataaaca tgggtaggtg tatctgaaga aggtttaagc gagccttcga 2713741 cgacctctcc atcaaggttc aaaacaacca agtcatcggc tgtcaggtcg ctgtattcga 2713801 ctccgctagg tttgatgaca attctttctt tttcacggtc aatgccgctg acatttcccc 2713861 acgtaaaggt taccagctga tgctcttgaa gcttcaggtt ggcagccagc acttcttttt 2713921 ttaatgtttc aagcatgctc catcaccctt tatcaattct ttttggcggc agatgaaaat 2713981 tgaagatttt tgatcgtttt cagacgcttc atgacatggt tttcttttcc gaaataatga 2714041 accagctctt tatattcagc gtacaatttt tcataaaccg cggcgttttc ggcatttggc 2714101 gtataagtta tatctttcag ttttcccatg ttcgccgctg cctttttgat atcatcgtag 2714161 ccgccttttt ctttgcctgc tgcaagcgcg ccgaaaatgg cagatcctaa ggctggggct 2714221 tgcggtgaac cagagatttt aatgtccatg tttgtcacat ccgcataaat ctgcatgaca 2714281 aacgggtttt tctcagctat tccgccggct gcgaacagtt cctcaatcgg aacaccgctt 2714341 tctttgaatg tttcgataat catccgggtt ccgtaagctg tcgcttcaac taacgctcta 2714401 taaatctctt caggcttcgt cagcagtgtc atgccaagca gcatccctgt taaatctgca 2714461 tcaacaagag ttgaacggtt tccattccac caatctaaag caagcaagcc gctttcacca 2714521 ggcgcttgat ggtttgcttt ctcactcagc agctcatgaa cgccaatgtt tttttccttt 2714581 gcttcctctt gataagctgg cgggacacat gttttcacaa accagtcaaa atgatcgccg 2714641 acacaggact gcccggcttc atatcccgca tagcccggga gaattccgtt gtccacaacg 2714701 ccgcacattc ctggaacgat atgcacctct tcaccaagta gaacatggca cgtcgaggtt 2714761 cccataatca tcagcatttt ccctggctct gtaatgccga ccgccggtac cgaaacatga 2714821 gcgtccacat tggcaaccgc aacagccgtt cccgggagaa gccctgtcag ctttgccatt 2714881 ttttcagtca gactgccggc tttttctcct actgaatgaa tagaacctga caatttgtcc 2714941 tttgtaatcg ttttcattga aggatttaat ttctcaaaga aatcatctga cggatacccc 2715001 gctttttcac tccacatcgc tttataccct gcggtacaat tgcttcgctt gagcgagccg 2715061 cacagctggt acacgatcca gtccgcagcc tcgatgatcc ggtcagccgc ttcataaatg 2715121 tgaggcgctt cctcggcaat ttgcatgacc tttggaatca tccattctga tgaaattttt 2715181 cctccgtacc gctgtaaaaa agcctctcct tcttcttccg cgatttgatt gagccgatca 2715241 gcatgttttt gggccgcatg atgcttccag agcttcacat agctgtgcgg ctcctcttca 2715301 tattcaggca gcatgcataa cggctgcccg ctgctgtcaa taggaaggat cgtacatgcc 2715361 gtgaaatcaa ttccaatccc gataatgtct ttcgggtcaa cgcccgtctg ttcgagtaaa 2715421 gacggaatgg ttgtttccaa gacttcgagg taatcagcag ggtgctgcag cgcccagtca 2715481 cgcggcagct tttgacccgt ttttggaagg acggtatcaa tgacagcatg cctgtattct 2715541 tttacagcag ccgcaagttc ctcccctgtt tggacatgaa cgagcactgc tcttcctgat 2715601 aaagttccaa aatcaacccc tattgtgtaa gccatgtgac atccccctct acttttgaag 2715661 ccggtaaagc gcctcgttcc attttaactc gtgtttcagt ttatgaattg tcgtatcacg 2715721 ggaaatgaga acactttcga ttcccgccat ttccgcccaa tcaagcattt gctccgctgt 2715781 cagttcataa gacaggcagg tatggtgtgc accgccggct aaaatccatg cctccgctgc 2715841 tgttttcaat gacggctccg gcttccagag aacacgggca accggtaaat tcggcatgtc 2715901 tttttcaatt tcctggccgt tgacttcatt cagcacaagg cggaaacgcc cgccaatatc 2715961 aacaatgcta gcttgaatgg cagaaccgct gatgccgtta aataccaaac gcgcagggtc 2716021 ctctttgccg ccaatcgaaa gcgaatgaac ctcgattttc ggctgatcca aagcgacagt 2716081 cggacacact tcaagcatgt gagagcccag aatcatttca tttcccggtt caaaatggta 2716141 cgtgtaatct tccatgaagg aagttctttt tcctttagcc atgattttca tcatccgtac 2716201 aagggccgct gtcttccaat ctccttcacc ggcaaaccca tagcctttct ccatcaggcg 2716261 ctgaacggca agtcccggca gctgtttcat tccgtgcagc acttcaaacg atgtcgtaaa 2716321 cgctgtgtat ccgccttgct caagaaaagc ggttaatcca agttcaattt tcgcctgttc 2716381 tttaatggac gctacctttg cttcgtcacg ttttgtttcc tcactgatca catatagtct 2716441 gtcatactcg gcataaagcg tgtcaacctc gtcgtccgta atgcgatcca tcacttcaac 2716501 gagatccccg atgccatatc cgtcaacctg ccagccaaat tgaatatgcg ctcccacctt 2716561 gtctccgtcc gttaccgcga catgacgcat gttatctcca aatctggcaa ccttaatatg 2716621 tctgctttca tttaatgcag ccgccgtatc catccactgg gacatttctt ttttcacttc 2716681 ttcatcatcc caatagccgg caatgacttt tcggctaagc cccattctcg agttgatgta 2716741 accgtactct cgatcgccat gcgcggattg gttgctgttc ataaaatcca tgtcaatcgt 2716801 accccacggg atatcgcgat tatattgggt atgcaaatgc ataagcggtt tttgataaga 2716861 ggaaaggcct tctatccaca tttttgcagg ggaaaatgtg tgcatccatg taatgatgcc 2716921 agcacatgtc tcactgtact ccgcttctct taacagctct ctaatggttt ccggtgaagt 2716981 gacgacgggc ttatgagtga ttttatatct ggaagaaatc ccgctgagcc cctcacaaat 2717041 gcttttagca tgctgatcta cgagttccag cgtctcttcc ccgtataggt gctggcttcc 2717101 tgtcacaaac cagaattcat aatcctttgt ctgaagcatg taaactgccc ctttctcata 2717161 aaataaaacg ctttcaaata caaaagatac gtactaatga tagaaaataa acctataaat 2717221 aaatatttgt acgaacaatt ttattatagt aattgactat tatactgtca atcttttctt 2717281 ttaaaaaaag ccgggggcag agcccggctt tttaattcaa taggacggcc agcccgagct 2717341 ccaattcaaa tcattgatga gaagctttgg aatgccgttg tcattggcat cataggcatg 2717401 gcgaacaaga atgtttccgt tcacaatatc ctggcctcca ggtcctttcc attggtcatt 2717461 gcccgaatcc aaaatggtgc ctccgccttc aagcatgctt tttccgcttt tatcaagata 2717521 agggcctgta atgcttttgg atcttccgta agcaattttg tacgtactgt ttaccccgtc 2717581 acagcattta tcaaatgaaa ccattaaata gtaatatcca ttttgatacg taagagtagg 2717641 agcttctaag gcacctccat tattcggtct agctgcaatc gaatagagcg agcctgtagg 2717701 cttcattgta ctcttatcga gcttagtcag cttaatgccg ctccaaaacg agccgaatgc 2717761 aagccacggg ttgccatcct tatcgaatgt cagctccgga tcaatggcgt tataattatt 2717821 tgagcttgtc gaacggatca ccaagccctc gtccttccag ccccccgaac tgatgcttgt 2717881 tgaagatgcc aggccaatgg cagatgtatt gcttccaaaa gaagaaacgg aataatatag 2717941 ccagtacttg ccgttatagt attggatgtc cggcgcccac tggttttggc cataattcgg 2718001 cacataattg gaccaccacg atagcggtgt agtgaaaatg gatttttgta cggtccaatt 2718061 tttagcgtct gaagacttca aaacccgcag tccccgttct tcagtaagcc ctgttccgag 2718121 cgcataccat gagctcccct ctttaatcat agtcgggtca tgaagcagct cattggatgc 2718181 accccaaaac gctgcctctg cgggagcagc agaagtgaat atcaaacctg cagccagagc 2718241 tgcactcgaa aagtgtaaga agcgtttcca tgtttttttc tttttcaatt ttgttcaacc 2718301 tcctttattt tagaaagcgc ttacaaatta gattatttat cctcccttcc tgtcaaatcg 2718361 actgcgtatc gtatatcgtc atgttcagga aattttcggt atccccttta ttgtagtcac 2718421 tatgctgtaa tttgtacaga caaaaaaata gaatccacct caataggcgg attcttccgt 2718481 atctttattg gtacgtaatt tcgtcaaccg tttttcggtc taacttctta atgacttctg 2718541 taattaactt taccgcgttt tcataatcat cacgatgcag catggccgcg tgcgtatgaa 2718601 tgtagcgggt tgcaatggta atggacagcg caggaacgcc atttgccgtc aaatggatgg 2718661 cacccgaatc agttccgccg ccggcaatgg catcaaattg gtacggaatg ccggcttcct 2718721 ccgcagtggc tacaactgca tcgcgcaaac ctttgtgaga gaccatggat gcatcgtaaa 2718781 cgataatctg cgggcctttg cccattttgc tctgcgcttc cttctcggaa atgccaggcg 2718841 tgtctcctgc tatccctaca tcaacaccaa acgcaatatc aggctgaatg gtgtgtgcag 2718901 ccgttttcgc tcccctcagc ccgacttcct cctgcacggt tccgacgcca tacactatat 2718961 ttggatgatc tgtgttttgt aagtttctta acacatcaat agcaatcgca cagccgatgc 2719021 ggttgtccca ggcctttgcg agtaggaatt tttcattgtt catgaccgta aattcaaaat 2719081 gcggaacgat catatctccc ggaagtacac cccactccaa ggcttcttcc cggcttgaag 2719141 ctccaatatc aataaacatg tcttttattt ccactgattt ttttcttgct tcaggagaca 2719201 aaatatgagg cggcttagat ccgataaccc ctgtgatttc tccttttttt gtgacaatgg 2719261 tgacgcgctg agcaagcata acctgagccc accagccgcc aacggtttga aaacggataa 2719321 agcctttatc tgtgatttgt gtcaccataa agccgacttc atccaaatgt ccggcgatca 2719381 taattttcgg gccgttttct gcaccagttt tttttgcaat taaactgccc aggcgatctg 2719441 ttgtcacctc atcagcaaat ggttctatgt atgatttcat cacttgcctt acttctcttt 2719501 cattgcccgg tatgcctttt gcatctgtta aatctttcag catggtcaat gtttcatcta 2719561 attttgccat gttccaaacc ctccttcatc agtcctgcat tcttattata caaaacatgg 2719621 cgctaaccat acgactattt cacttgaaaa tcgggtatat gtttttacag ctttctttta 2719681 gaaaaagtga aacctttttc tatgcttttc gtattacatc agatcatcac cataagggag 2719741 gtgccttcac acaatgtttg tcatggttct aaggattatt ttgcttgcac tttttgctta 2719801 ttgtatttat gccgtggtca aatatgtcgc gaatcctaag agaaggctta agctggccca 2719861 atcaaaagaa catttttata ttattgatga acaaaacaat acccggaaga attttcagct 2719921 gacgtataaa ggcgtgcttt ttgagggaga aaagcatatt ccttccaagg atcatccgct 2719981 gtttattcac acgatctttg tctggacaga atctcctgag aagctgaaac atttctctgc 2720041 aaaagatttt gagaacattg aagaaaaagt gctggaacga tatccaaatt gtaagattga 2720101 ctgggaccag cccattaaac tcgcaaaaaa agcagaagag cgttaaacgc ttttctgctt 2720161 tttataaatc aaacgggctg tagtaaatag cgatgagaat cgcttctatt accagaagaa 2720221 gcggtactcc gtacttaaaa gaagcgtgtt tcgttttatg tctgaaggtt tgcatgccaa 2720281 gccagacacc gagcgctcca aacacgatgg ctatcagcca cagccggtct tcagaaattc 2720341 tccacttgtg ctgctgcgct ttgcgtttgt caatgcccat cacccaaaaa ccgcacagat 2720401 taatcaacac caaataagca gcaataatca tgttgcctca tcctttatat agaaaaagcc 2720461 gctctgctgg agagcggctc tatatgatta cttgtttaat tgagctttag cagcatcagc 2720521 aagctgattg aatgcagtaa gatcgtttac agcaagatca gcaagcattt tacggtttac 2720581 ttcgatacca gaaagcttaa gaccgtgcat taaacggctg taagaaaggc cgttcatgcg 2720641 agcagctgcg ttgatacgag tgatccaaag tttacggaaa tcacgttttt tctgacgacg 2720701 gtcacggaaa gcatagtttc cagatttcat gacctgctgg ttagctactt tgtataatgt 2720761 atgttttgaa ccgaaataac cttttgctaa tttaagaacc tttttacgac gcttacgtgt 2720821 aacagttccg ccttttactc ttggcattga atttccctcc taattgttcc ttatccgatt 2720881 acttgatgtt agcaagcatt tgtttgatac gtttgaagtc tcctgcgctt acaacagcac 2720941 tcttgcgaag cttacgcttt tgcttttgag atttgttggc gaataagtga cttgtgtacg 2721001 cgtgagaacg ttttaacttc ccagaacctg tctttttaaa acgtttagca gatccgcggt 2721061 gagttttcat ttttggcatg ggatttcctc cttattgctt ttcgtttttc ggtgcgagca 2721121 ttaagaacat gctgcggccg tccatttttg gttttgtttc gactgtcgca acctcagcac 2721181 atgcttcgga gaaacggtct aatacacgct gaccgatttc tttatgagtg attgcgcgtc 2721241 ctttaaagcg gatagaagct ttcactttat cgcctttttc aaggaattta atcgcattgc 2721301 gcaatttcgt gttaaagtca tgctcatcga ttgtcggact taaccgaact tcttttaagt 2721361 taatgatttt ttgattcttg cgtgcttctt tttccttttt ctgctgctca aatcggaact 2721421 taccgtagtc catgattcgg cagacaggcg gttttgcatt cgctgcaact aacacaaggt 2721481 caagatttgc gcggccggcg atttcaagtg cttcctgacg ggacttgatt ccaagctggt 2721541 cgccattttg tccgattaaa cggacctcac gtgcacggat accctcatta accaattgat 2721601 ctttgctaat aatgagccac ctccatagtt tcttcgaatt gattcacaac tcattttgaa 2721661 tgcattttgc aggcaaacaa aaagtgtggg cattataaaa cacccacact acgaacatct 2721721 gtatcaataa aaatgtacgg tcaacctgcc aactacatgc atgtgtcaat caggtgagaa 2721781 gcgggtgctt ctgcttgtga tttatattca attcaataac tattctacac aataccggat 2721841 ctttagtcaa ggacgactta tccggaacaa cttttacatt gtaacatggg ttttctatga 2721901 gcgcaagaga gaaaaagaaa atctttcatc cccacccaga atacaaagaa ccaacaattc 2721961 ccccttatta cgcaatttac aacaaaacca ccgacaggaa gaaatgtaaa acaaagttaa 2722021 tctctgaccg atataaggag cagaagggag cctgacacat gaacaaactg atacagcttg 2722081 ctttattttt cacattgatg ttaaccggtt gctcgaatag cagcacatct tccgaatcaa 2722141 aagtcgaaac cactgttaag acaacggcag catttcctca aaaggagctg gagaaagagc 2722201 taaaaaaact aaaacccgtt tcattggaca tgaagttcga gagtccactc gctaccgagt 2722261 taggaaagcg gaaggcaaaa gaggaagctg aaaagcaaag acaaatcgcc gctgagaaaa 2722321 agcttgaaaa agagcgggag gcgaaacgaa agaaacagca ggaggaaaaa gcggagagac 2722381 agcgattagc agagcagcag gctgcagaga gacagcgatt agccgaagcg gaaagacaag 2722441 ctgaacttga aagacagcgg caggcagcaa tccaaaaaga gcagaaagcg aacgctgaga 2722501 aaaagcggca atcgcaggca caacggcagc agactgaggc accctcatct aatagtcaag 2722561 atccaccatc ttcctcgagt cagacagata aaaccattca acagccagct tcagagcttc 2722621 ctgatgacga tggttatggt tatgaagaac gaaaaaagtg gcatgacgat caagtagaat 2722681 ggggcattaa acaagggtat atcgatcccg aagacgcacc ataaaataaa aaaagccaag 2722741 gcattcagcc ttggcttatc ctccgatcag ctgcacgaac acagggatga ccagaaccgt 2722801 taccactcct actacgacaa cagcaatact tgccatcgca gcttcaactt ctcccatctc 2722861 aatcccgacc gctacaccaa gtgcatgtcc ggatgttcca agagccaatc ctttagaaat 2722921 cggatttttc actttaaaca ccttcaagaa caatgctccg agcgcatata cgatgacagc 2722981 gttaaagatg accgcaaagg ctgtgatgtc gctgatgccc ccgatgcctt ttgataaagg 2723041 aagcgcaatt gccgttgtag ccgcctgcgg aagcatgctt ttcattacgg ccgaatcgag 2723101 atgaatgcct ttagcgagca gataaacaat cgtgacagag cagatagagc cggcaataat 2723161 ggaggccatg atttgccacc agtacttttt aagcttatct ctttgtttgt acaaaggaat 2723221 tgcaaatgcg atcgttgccg gttcaagaaa aaacttaatg atctctcccc cgttattata 2723281 atccgcgtag gaaaaaccgc cgatttttaa aaatgcgatc cccagcacca tggcaacaaa 2723341 caaaggagtg aaaaggaaga agcctttcgt tttcttaaat aaaaaggtgc cgatgccgaa 2723401 tgcagcaagt gatacgacaa tcccaaaata aggactcatt gtgctttcca tgtgaagaac 2723461 ctcctgtttc ccttaatggt gaacgagttc gttattgttc tgcgggcttt gcactgtttt 2723521 tgttttcatg tccgcttcgg ttttgcgttt tccgctcagc gacagaatca gctgagaaaa 2723581 caatcccgta gcccccagca aaataatcgt tgcgagcaga atgacaagaa caatttgcag 2723641 gccgtattgc tgcatcacac caagcgaatt cataacagat atacctgatg gaacaaataa 2723701 aaatccgatc agagaggtta aagacgttcc gagcgtctcc acttgttcca gtttaatgac 2723761 tttcaaacat aataggagaa ataataagac caaccctaca accgatgccg ggataggtat 2723821 tgggacaata gcggcaatca tatttgaaac cagcataatg acggcaaaaa taaatgcttg 2723881 tgttaaaaac ccgtacactt ttttagcact cattttcttc acctctttct ctttggtacc 2723941 ctcattataa ataagaattc cctgttataa agcgcttaca agataacatg ccgtatagcg 2724001 ggtctgagtt gcagaatcaa atggctgaaa tgcaaaaagc cgcccatcaa atatggagca 2724061 gctttttcaa ttccttcgca tatgtccggc tgaccggtat tttcgatccg tctttcatga 2724121 tcagattata cgttgaatta aaccatggct gaatttcttt aatatattca gtattcacga 2724181 caaagctccg atggacgcgg ataaaatcag aatccggcag ctttttctca atcacaacga 2724241 gtgtatcgct gaccgtataa gaatgatcga aggtttttac attgacatga ccatcttctg 2724301 ttccggcata gataatgtcc ttcgtatcca caatcacaat cgattccccc acagatagcg 2724361 cgagcttgtg ctggccggca tggctgtttt gctctgtttc tacaatatcc cgattgactt 2724421 ttttatattt tttcagcgtt tgctgaattc tttcttcatc gaaaggcttg gttaaataat 2724481 caagagcgtc cacctcaaac gctttgagcg catactggtc atacgctgtc gcaaacacaa 2724541 tagcaggagg atgcttcatt ttcttcaatc gctttgcgat atcaaaaccg ttttctccgg 2724601 ataaatcaac gtctaaaaac agcaaatcag gtttttgatc catcatttgg tcaaaagcgg 2724661 attcgatatt ttccgcttca ttgatttcca tttcatcatt ggtccgctta agcaagtaag 2724721 ccagttcatc ccttgccagc atctcatcat caactattaa caccctgagc atgttcttct 2724781 ccctctttca tctgttgcat tggcacttga aaggaaacct ctgtcccttt atgaacctca 2724841 ctgctgatat gcagtgcagc ctgctgtccg aataaaccga tcagccgctg atttaggtta 2724901 taaagcgctg taccggttcc ctccttagac ggaaacggtt tcttccccag ttccggcaag 2724961 acgtccggcg gaattccgcg tccgttatcc gccaccttca tatagacgga tgcatcatca 2725021 gataagacac agactgtaac cttgcatatg tcttgttttt tcggaaacgc gtgccgaagc 2725081 gcgttctcga caagcacctg caaaacaaac ggagggattt caatctgctc cagtctgctg 2725141 tcgatattaa gctcaatttt atatttcccg ggaaaacgcg cctgttctaa tgacaaatag 2725201 gcgttaagat ggttcagctc ctttgagagc ggaatcagca gctgtctcgc tccttgaagg 2725261 tttgaacgaa aataaacact gagctgcaat aggagcttac gggttttttc aacatctgta 2725321 cggcataacg cagaaatcgt gttgatcgca ttaaataaaa aatgcggatt cacctgtgct 2725381 tgaagcgctt taatttcagc atccttgaga agtttgcttt gcagctctgc ttccccaagc 2725441 tcaagctgtg tcgaaaacag catggccagc ccctcggcaa gttcctcctc tacctgactc 2725501 aggcctgccg ggcttttaaa gtacattttt aaggtgccga ttgtattgcc gttcgatgtc 2725561 agcggtagga caattgcagc gtgcaaaggg cattcagcat gcgtgcattc aatctcttcc 2725621 tgcgaaatcg ccttcataat atgccctgtt ttaatcacct ttttggacag gccggtgatc 2725681 aagcttttcg atgggatgtg gtgatccatt cccgcaccga catgcgcaag gatcttttct 2725741 ttgtcagtga gagacaccgc atctgttcct gtcagcttat ggataatagc cgctacactt 2725801 ttacaggagt tttcatttaa tccttggcgg aaaaatggaa gtgtctgatc agcaatcgta 2725861 agcactcgat gcgtttcgag agcccttgcc tgttcttcct tgcgaatgat cgcttgaata 2725921 atagacagaa aaataaaact gcctgttcca ttgatgagta tcatcggaat tccgatcatg 2725981 ctgacaagct cccaagcgtc actgaacggc tttgccatca gcaaaataat gatcatttgc 2726041 agtgactcca tgccgattcc cacaagagcg gcgatgcgcg gtgtcggcat tcgatatcgc 2726101 ttcgtaaaat acctgccgat caagcctgca agaacacccg ctaaaataga tgagacggca 2726161 cagcttaagg ccgtgctgcc accgagtgaa aaacgatgca ggcccgcaag tatgccgatc 2726221 ccagccccta caaaaggacc tccgagaagg cccccgattt ccacgcccaa aatacgggta 2726281 ttcgcgatag agcccgatgg atctatcgta aacacccagt cattgtttac aatcatattt 2726341 ctttgaattt cgatgcctgt ataattgctg atgatgctga aaagagaaaa aatagaaatt 2726401 aaaatcgctt ttcctttata gccgtcctga ttctgaagag cttgtctgaa aagtttcgta 2726461 tgggcgagaa tgaaccctaa tataacaata atccccactc tctccagcat cataatcatt 2726521 aaatgaatca ttcatgtcac ctgttctttc cgttttcatt ctagcatgtt ttcgttttgc 2726581 ggctgactgt ttttttaaaa tcgtctgaaa acatatttca caaggctttt atctattgta 2726641 aaataaaaca tgagcctttt ggcagaaaga tttgaatctg aagcagagga gaagatcatg 2726701 aaagccgtat tttttgattt agatgataca ctactttggg acgaaaaaag cgtcagaaca 2726761 acatttgcag aaacttgctt acaggcggag aaaaaatatg gccttgcccc tgaggaattc 2726821 gaagcagctg ttcgcgaagc ggcgagagaa ttgtacatgt catatgagac gtatccatat 2726881 acagtgatga tcggcattaa cccgtttgaa ggactgtggt ccaatttctc agagccaatc 2726941 agtgaaggct ttcaaaagct gaacaagatt gtgccggagt acagaagaaa tgcatggacc 2727001 aacggactga aagcgcttgg gatcgatgat cctgcatatg gcgaatactt gggagagttt 2727061 tttgcggcag agcgcagaaa gcgcccgttt gtatatgatg aaacttttgc tgtactcgat 2727121 caattaaaag gcaagtatga attattgctt ttgacaaatg gcgatcctag tctgcaaaag 2727181 gagaagcttg ccggcgtgcc tgagctcgct ccttacttca atgaaatcgt catctcgggc 2727241 gcattcggca agggcaagcc ggatgtttca atttttgaac actgccttaa gctgatgaat 2727301 attgaaaaag acgatgccat catggtcggc gataatttga atactgatat tttaggcgct 2727361 tcaagagccg gaatcaaaac cgtttggatc aaccggactg ataagaaaaa cgaaactgac 2727421 gtaaagcctg attacatcat cagcagcctt catgatttgt ttcctatatt agagaaataa 2727481 aaaaagcatg atctcttcaa tgagatcatg cttttttatt ttattttttc gcttcagcta 2727541 ctgccttttt cacaaactca tcaagtgaaa tggtttcaga gttctgttct ccgtatttac 2727601 gcacgtttac cgctccgttt tctgcttctt ggtcaccgac caccagcatg tacgggattt 2727661 tttgcatttg cgcttcacgg attttgtagc cgattttttc atcgcggctg tcgacttcaa 2727721 cacgcaggcc ttcacattgc aggcgttcct gcactttttt cgcgtagtct aaatgcacag 2727781 ccggagaaac cgggatgact tggaactgaa ccggtgcaag ccatgtcggc agcgcgcctt 2727841 tgtgttcttc gattaagaaa gcaacaaagc gttccattgt tgaaacgaca cctctgtgaa 2727901 tgacaaccgg acggtgctgc ttgccgtcct caccgatgta tgtcaggtcg aaacgttccg 2727961 gcaataagaa atcaagctga accgtagaca gtgtttcttc ttttccgatc gcagttttca 2728021 cctgaacatc aagtttaggt ccgtagaatg ccgcttcacc ttctgcttcg taatagtcgt 2728081 ggccgatttc atccattgcc tctttcagca tggattgcgc tttgttccac atttcatcgt 2728141 catcaaaata tttctctgta tcttccggat cgcggtaaga cagacggaat gtgtaatcac 2728201 ttaaaccgaa gtcttcataa acatcctgga ttaaacggac tgtacggata aactcatcct 2728261 taatttgatc cgggcgcaca aagatgtgtg catcatttaa cgtcattccg cgtacccgtt 2728321 gaagtcctga cagcgcacct gacatttcat agcggtgcat cgttccaagc tctgcaatac 2728381 gaatcggaag ctcgcggtaa ctgtgaatgt cttgtttgta aatcatcata tggtgcggac 2728441 agttcatcgg acgcaataca agtgtttcat tgtccatttc catcggaggg aacatgcctt 2728501 cctgataatg atcccagtgt cctgatgttt catacagctc tttgctgcct agcacaggtg 2728561 tgtatacgtg ctcatagccg aggctgattt ctttatcgac aatgtagcgc tcgatgacgc 2728621 ggcggattgt tgcgcctttt ggcagccaaa gcggcaggcc ttgtccgact ttttgagagt 2728681 tcgcgaacag ctttaattct ttgccaagct ttctgtggtc gcgttctttc gcttcttcta 2728741 gcatacgaag atgctcttca agatcagctt ttttgaagaa agctgtacca tatacgcgct 2728801 gaagcatttg gtttttgctg tcaccgcgcc agtatgcgcc tgcaaggctt aacagcttaa 2728861 attctttgat ttttccggtt gaaggaacat ggacgccgcg gcacaggtca aagaattcgc 2728921 cttgctcata gatcgaaacg gtttctcctt caggaatcgc atccaatagt tcaagcttca 2728981 ggtcgtcgcc gatttccgca aaacgggctt tcgcttcttc acggctgact tcttttcgaa 2729041 cgatcggaag gttcgcatta acgatttttt tcatttcttt ctcgattttc ggcagatcct 2729101 ccggtgtaat cgcttcgtcc atttctacat cgtagtaaaa accgttttcg ataaccggac 2729161 cgacgccgaa tttaacatcc ttgtagatgc gtttaatcgc ttgagccagc aagtgagccg 2729221 cactgtggcg cataatttga agaccttctt ctgagccttc tgtaatgatt tccactgtac 2729281 cgtcttcatt gatcggcgtt ctcaaatcga tttcttttcc gttcagtttt ccggctaatg 2729341 actttttctt taatcccgga ctgatggatg ccgcgatatc ttctgttgtt gttcctttcg 2729401 caaactcctt gactgctcca tcaggaaatg tgatttttac catatctgac atctttgtca 2729461 ctcctttttt tgcatataaa aaccccgccc cctatgaaag ggacgaggtt gaataaacgg 2729521 aatcgtggtt ccaccctttt ttccgcaaag ccaatacacg gcacctgcgg ctctaagctc 2729581 tgtaacggga gttcccgtca gccattactg ttccttttca agaggttcac agctgaagtt 2729641 caaaggcggt aaagcgaatg gtccttagct gggaagcttg cagccagggc ttccctctct 2729701 ttgagccggt atcattcctt cgtgtcctta tcaatacgtg tgtctttctt aatctcctat 2729761 gtattataaa ttgttcaatc caaaaaatca acacgatcgc gtttcctttt ttttaaaccg 2729821 acagccttaa atagacaggc tgccggccct catccttccg agtgcttcac cggtatttct 2729881 gcatctgtaa aagcatgcag cgggagcatt tccactctct cttgaaatac gttttgaatg 2729941 gtccttgcca tcatgtgctc gggctggtcg gtataaagca cgacttcatc aggcgcaatg 2730001 gaaatcagcg gcgcgagcaa atgagaatca atatacatag gatgatcccg gacaaatctt 2730061 ctgtctatgt atttcatttt ttcccgttcc ggcacatagc gcagctccca taatgtaaag 2730121 gaaccatcat ggacaatatg cacttttttg attcgcggct gtttggcgtc cacatagtct 2730181 ctgagtgttt gaataaagtt ttgatattcc tgttccatct tatattcatc aatcgctgct 2730241 tctgtaatat ctctcagctg cttatagtat gatccaagtc ggaaggtctg aaaggagcga 2730301 atgtaaaata ctccttcctc taaacagatc gtttggagtt catccaaaat tgattgtttc 2730361 cgtgaaagct tcagcggctc aaacggaaga tcgtctgctt caccttcaat aatactgtgt 2730421 gcgagctgaa ggatttgctg ctgttcatcc tggtccgtga aacaatacgt ttcctcaatc 2730481 aatgacagca tatgctcgtc ttctttgcat tccaaaaaaa atttgaccag aatcggctcc 2730541 ataaaacgct gaataggaaa agccggattc gctttttcaa tcccgatttt tcgtatgcct 2730601 tcacggacaa tgatattgtt ccgatcgtcc gaatgctgaa tgagatgtaa aaaagcggct 2730661 gcatcatggt catcttcaaa gattatttca agcatgtttg tcccccctta cggcatctgt 2730721 tacaagtata tgggggatgt ttttaaaata gacgtaaagg tcattggcaa atcttaattt 2730781 gattcttgga acaagttttg cattttcttt ctgaagatga acggcaatga gataaacacg 2730841 atatacaaag cgagcaccat aaagaaagcg ggcagattgc cagccaaaaa gctcgcaccc 2730901 agcacattaa gcgcaatcgt cccagggatg attcccacag ccgttgcggc aaaatacggc 2730961 agcgctttga cattggaaag gcctgccgca tagctgacga aatcaaaatt gatcggcagg 2731021 attctcaaaa gaaagatata gaaaaatccg ttatcctcca tttgcttctg tatggcttca 2731081 agcctttcgt aatgcccgtt ctttttcgcc gaaaacaaac cagccgcaaa aaacgaaaca 2731141 gctgaagcgc acatcgaacc gaataacgta taaagcgtgc cgagaagcgg gccaaacgca 2731201 agtccgccag ctattgaaat aacagacacc ggaaataaaa caagtggcct gacgatggat 2731261 atcccgataa acatcagagg tgcaaagact ccgaacgaca atacccatac cctgatttct 2731321 ttcggcgata cattcaaata cgttttattt ccccaataga gtaaaccagc acctgcaagc 2731381 actgccagcc atttgacagc cgtttttcgt ttcataccct cagttccttc ccctttgaac 2731441 cacagcaatt atggatgtcg gcggttttct ccgtcaaggc ggatcggagc agccaaatat 2731501 aatatccgct ccattaatct tgcagctttt acttcttctt tttctcccct ctgcgaatac 2731561 gtaaaatgat gcttcagctc gtcaggtgag aaattagaag aaaagaacgt tggcagctgc 2731621 tgggacattc tgtgctgaag caccgttccg atgacctcat cccttaccca gcttgtcatt 2731681 gattctgctc cgatgtcatc aagcattaat acgggtgtgg tctttaccat attgagcttc 2731741 tcttccaatg tctggtcttg cagcgaattc ttaagctctc tcacaaattc aggcacataa 2731801 acaatcatgg aggaatactc tttttccgcc agctcattgg caattgcagc gagcataaac 2731861 gtttttccta ccccaaattt cccgtataaa tataatcctt tcccttttcc cgtctcatta 2731921 tagcttttca ggaagtctgt aacatgctga aacatcgcga gtctgcttgg gtcactgata 2731981 tcaacttgct ggaacgtcgc tccaagaaga tcctgctgga tatacatgct tttcataaga 2732041 gactgttgtt tcttctgctg gtcgagcttc cgtttgactg gacattcgta atactcgata 2732101 tcaatagacc tcccattgac aacaagcttc ggatggtagc cctccaacaa attgttgcag 2732161 ttttcatctt ccgaacaata ggagcaattc ttgctttgtt cgatatattc ataaagctta 2732221 tttaagctct tttcgatcat tttttggtca atcacttctt cgttttcctt caaaaatgct 2732281 tgaacatctt gatctttcat gactttttcc ttcatttgtt caagacgttt ttggaaatcc 2732341 ggcctgccgg ttacgccctg cagggaacgg ccgattggtt ccatctattc cttcaccccg 2732401 catctctgtc tttaataggc agagtatttt ttcagttttt gcatttcttc catcatcttt 2732461 ttcttctgtt cttccaaatc ctgcggatgc agcttctgct gtccggattc tgaatcggac 2732521 gctgtttcct tttctgtcat ccaatcagga agcttttctt cacgaatcac tttttggttt 2732581 cgtttcgaag actttgtttt tccctcagcc cattcaagat actggcggtt ttcttctatt 2732641 gcgagcttca tcgcttccct gaccgttttc acctttttgc gtgcccaatg cgaagcgatt 2732701 ttttggatat agtttttcga cagcttcatg tcggttttca gcatgacata ataaattaac 2732761 acatttgtga cgcctggctc gagcttctgt tcgaacataa tttcttctat gatcttcaga 2732821 tcagcttttg acggctctgt tccgtcagca atgtcctgca gaagcttctt cggggaaatc 2732881 gcctccagca atgcaatcag cttcccatcc agagaatcct cttctgccgg ttgttcgcct 2732941 tcacgcagat gcaccggctg tgttttttcc accaaatcgg gcagctgtcc gtttctttca 2733001 atttgatacc agtcgctcgc cgcttttctt aatgcctccg tcgtaatgac gtcacgctca 2733061 tcaattgcgc tcatcacaac attttgcatt tgcaaagggt caattccgta cagataagaa 2733121 agctttttga ttgtgtcccg cacctgctgg gtcatcgctt ttctcggtat catcgtctca 2733181 gaaagtcccg ctaaaaacaa atcaaaatca aacacatcct ccgttatggt gtaggacgga 2733241 gactgtccga cagaagtata ctcggacccc tcggcaagcc ttaccgtttc ctccatatcg 2733301 gatgtgagct tccattcact cggctgcagc gattcaaacg catgattaaa cggacgcgta 2733361 atgtccttcg catcttctga aatggccggg tgcgtaaaaa attgttttaa ttgctgatat 2733421 ttcgtttttc cgaccctatt atacagaaaa acattcagca ttccgtcttc aaaaaattca 2733481 tttggtctga gcggcggaag gagttcatat ataaagaggc gctcctgccg ctcggattct 2733541 ttcatatata ctttcagcaa tccgatgccc tcgagcttcc cctgttcctg atggatcgtt 2733601 tttaagttgg actgtgtcat ccccatcagc tgtctatgtg tggactctcc gccccacaga 2733661 cggttttgtt caagctctcc ccacaatgtc atataaagag agaatgcaac agggccgatt 2733721 aagggctggt acagttgtgt aataatttgt ctgtcaatat cctgcagcat cgatctgctt 2733781 ttaaccacat acgggtctac aggcagtaca tctttccaat agtcagccat acattctcaa 2733841 accttccgaa tttgtttcta cctttcattt tacaccgttt cttatatcta tcaaatgcca 2733901 attttgcaca tgagaaaaga gctagaagaa tcctcttagc tcttttaacg ctctttcttt 2733961 attaagtctt ttaattcatc gataaagacg tttatatctt taaactgccg atagacggac 2734021 gcgaaccgca catatgcgac ttcgtcaatc ttagccagcc ggtccatgac catttctccg 2734081 acgagctcac tcttcacctc ggagcagcct tgattgcgaa gttctttttc aatatcaaag 2734141 cacatgtctt caagcgtttt gagtgaaaca ggcctttttt cacatgcttt tatgaggccg 2734201 cgcagcattt tttctctgct gaattcctca cgcacacctt cttttttcac aacgatgagc 2734261 ggggtttcct ccactttctc aaaggtcgta aaccggtagt ggcaggattc gcactcgcgt 2734321 cttcggcgaa tcgactttcc gtcatccaca ggccgtgaat caaggactcg tgttccgtta 2734381 tgctggcatg aaggacattt caataaaatc agctcccaac tatatcgttc cctgcaatgt 2734441 attttcggca gcctccgcct tttaaaaata gatgtgacag catctgtcgg gagagccgtt 2734501 gttaaatttg tttctatagc attaggtggt ttgtgaaaat ctccttctta ttttacaaaa 2734561 aaaatgaaaa aagaaaaagc tgacactctc gtttctttat aaaaataaaa ggagcataag 2734621 ctaaaaagcg cataatggct ttctagcttc agctcccttt gtgttcgcaa tttactttat 2734681 agtactttcg cttgcgcctg tttaatttgc acaggcccca ttcctcttgg tatttcaatg 2734741 ttttctcttg tatcagcatg taatgcctct gcaatgtaat cagcagcgac attaggatct 2734801 aagtctccac aagtataaac atcaatgctc gcatatccgt gctcaggaaa actgtgaatc 2734861 gttaagtgtg attcagaaat aatcacaact ccgcttacgc cttgcggtgc aaatttgtga 2734921 aatgcaacct cgcgcacctc agcacctgat tttagagcag catttacaaa cgttttttca 2734981 ataaaatcca tgtcattcag cttatcaaaa tcgcatcccc atagctcgga gataacgtga 2735041 cgccccattg tttccatagt catggacccc ccttaacaag aattaaaaag tgaaattcca 2735101 acaactgggt cggccattta ccacggggga aagttagtcc ggagaggtcc taacccttta 2735161 agtaattccg aaacagtctc aagcaagaag ttcacgaaaa atagtatact gtgtttaagt 2735221 ctaatttgca aggtgcgttt tttcagaaat atgctgttaa gggttttttc tttaaaatgt 2735281 gtccatgacc ttattttata cagcagacgg atgtttcatt cgtgccgcta catggcggat 2735341 tagatcaaca actctgcagg agtagcccca ttcgttgtca taccacgcca gcacctttac 2735401 tttcctgtct tccattacca ttgttgtaag cccgtcaatg accgctgaat gcggattcgt 2735461 attataatca gtcgaaacga gcggttcatc tgagtaatca agtacaccgt acatcgacgt 2735521 tttggcagcg cgtttaaatg cctcgtttac ttcttcagcc gtaacatccg ttttcagatc 2735581 aacaacgaga tcaaccaatg agacgttcgg aacagggaca cgcaaggcga ggccgtgaag 2735641 ttttcctttc agatgcggca gcacaagcga aagcgccttt gccgctcctg ttgttgttgg 2735701 aatgatggat tcaccgcaag cccgcgcccg gcgcaaatct ttgtgcgggt tatcaatatt 2735761 tttttggtca ttcgtatacg catgaactgt agtcatcaga ccgctctcaa tgccaaactc 2735821 ttcatccagc acttttacaa caggcgcaag gcaatttgtc gtgcatgacg catttgaaat 2735881 aatgacatgg cgctcagcgt cgaattggtc ctcatttacg cccatcacaa tggtaacgtc 2735941 ttcatttttt cccggagcgg tcaaaatcac tttttttgca cctgcttcta tatggcccat 2736001 cgctttatct ttagcattaa acttccctgt tgcttcgacg actatgtcaa tatcatattc 2736061 ccgccaaggc agctgttttg gatcacggct gtttaacaaa agcactttct ttccatttac 2736121 gatcaggcta tcttcaccag ccacaacctc tttgtcgtat ctgccgtgaa ttgtgtcata 2736181 ctttattaaa tgagccagcg tttctgcgga atagctggcg ttaatggcca ctacttgaat 2736241 ttgatcgtct aacatcgctt ttctaaaaac cattcttccg attcttccaa acccgttgat 2736301 cgctactttt accttcatgt tggacacccc ttatcaatta tgccatccta atttgttact 2736361 atctaaaatt agtataacac attaaaacaa attcgccagt acatattgat aaaaatcaac 2736421 gattataacg ctaatttatg atgcatctta tgttttcttg cacagaatat caggcgtaag 2736481 aaccaaaaag cagccagcgc tccgcactga ctgccctcat gctttatgat tcctgtttta 2736541 acttatcatt gagcacactt tcttctagca cagaaaatgt atccccgtac actctgttaa 2736601 tatgattcgc tccccaagca cacagcatat ctaaaatccc ttctaagctg cggccgtatt 2736661 cgctgagctc gtattccact ttgggaggaa cttgattata tacgattcgg ttaatgacac 2736721 cgtccgcttc cagctcgcgc agctgctgag tcagcatttt ttgcgtgata ttgggcatta 2736781 ggcgttttaa ttcacttgtg cgtttttttc cgtgcgtcag atggcataaa atgacgcatt 2736841 tccatttccc accgatcact tcaagagtcg cttcaacaga aatgttatat tttttcttct 2736901 ccatacaatc cattctcctc acaggcacca aaaagtgact atagcacttc aaagtacgta 2736961 cttttatttc ttaacgatat gtttcataat cacatttgcc ggctgatttg aatctgctct 2737021 tttttattta tatagcttac tcggcagaat ttcaatcata caacacatct tacaaaggag 2737081 gaacatcatg acttcagcca ataaaagcaa tattcctgca ctactggctt tggccgtaag 2737141 tgcattcgca atagggacaa ctgaatttat cagtgtcggc cttttgccgc tcattgctga 2737201 tgacctggat attcccgtca cgacagcagg attgaccgtt tccctttatg cgctcggcgt 2737261 tacatttggg gcacctatat taacttcatt gacctcaagc atgtcacgta agacactatt 2737321 gctttggatc atgtttattt ttattgccgg taatacgatg gcagcaaccg cttcaagcat 2737381 cgggatttta ctagcagcac gtgtgatatc ggcattttcg cacggtgtgt ttatgtcgat 2737441 cggttcgaca atcgcagcgg atattgtccc ggaggataaa agggctagcg cgatttcaat 2737501 tatgtttact ggcctcactg tggcaactgt aaccggagtt ccttttggga catttatcgg 2737561 ccagcagttc ggctggcgtt tcgcctttat ggtcattatc gccgtcggaa tcattgcttt 2737621 cattacaaat ggcattcttg taccgtccaa attacgaaaa gggacgaaaa caacgatgcg 2737681 ggatcaattg aagcttgtga caaacagccg gttattgctt ttatttgtca ttacagcgct 2737741 tggatacgga ggaacattcg ttgtgttcac gtatctgtct cccctgcttc aggaagtaac 2737801 aggcttcaaa gccgggactg ttgcagtgat tctgctcgga tacggaatag ctattgctat 2737861 cggcaatatg attggcggaa agctgtcaaa ccgaaatccg attgccgctt tattctatat 2737921 gtttatcgta caggcaatcg ttctattcgt actgacattt acagccccgt atcaagcagc 2737981 agggctcatt accattctct gtatgggatt gctggccttt atgaacgtgc ccggccttca 2738041 ggtgtatgtc gtcatgctgg ctgagcgttt tgtcccgagt gcagttgacg tcgcatccgc 2738101 gatgaatatc gctgccttta atgcagggat cgcgcttggg tcataccttg gcggtgtgat 2738161 caccgattca atcggattga ttcataccgc ttggataggc ggattaatgg tggtcggtgc 2738221 agtcatttta acaggctgga gccgcttgat ggaaaaacga gatcggcagg aagcctgaca 2738281 attttaaagg aggaaataaa catgacaaca catttacaag caaaagcaac acttcataat 2738341 ggggtagaaa tgccttggtt cggcctcggc gtgttccaag tggaagaagg atctgaactg 2738401 gtaaacgcag ttaaaactgc cattgttcac gggtaccgca gtattgatac tgcagcaatc 2738461 tatggaaatg aagctggagt cggagaaggg attcgggaag gcattgaaga agcaggcatt 2738521 tcaagagagg atctgtttat cacatcgaaa gtatggaatg cggatttagg ctacgaagaa 2738581 acactcgccg cgtttgaaac aagtctgtcc aaactcggtc tggattattt ggatctatac 2738641 ctcatccact ggcctgtaga aggaaagtat aaagaagctt ggagagcgct tgaaacgctg 2738701 tataaagaag gccgtatcaa agcgattggc gtaagcaact tccaaattca ccatcttgaa 2738761 gatctgatga cggcagctga aattaagcct atgattaacc aagtggaatt tcacccgcgc 2738821 ctcacacaaa aagagttgat aagatactgc caaaatcagg gcatccagat ggaggcttgg 2738881 tcacctttaa tgcagggaca gctgctggat caccctgtat tggctgacat cgctcaaaca 2738941 tataataaat ctgtcgcaca aattattttg cgctgggatc tgcagcatgg cattataacg 2739001 attcctaaat caacgaagga acaccgcatt aaagaaaatg caagcgtatt tgactttgaa 2739061 ttaacgcagg atgacatgaa ccgaatcgat gcactgaatg aaaacttgcg cgtcggtcct 2739121 gatccggaca actttgattt ttaatggcca aaaaacaccg ttcaatatga acggtgtttt 2739181 ttgtattatg cccagctgtt catgatttca tcaagctgcc ttttggtctc ttcaagcgtg 2739241 ccgctgttat caatgacttg atctgctctt gctgtttttt cctctaaggg catttgagag 2739301 cggatacggc tgactgcttc ttcttctgtc agctgattgc gcttcatcag acgttccagt 2739361 tgaagctctt ttgtcacact gaccacaata attttatcaa ccaatgattc caatttgctt 2739421 tcgaacaata gcgggatatc caatacaaca aatgcctccc gatttgcaac ggcttcatca 2739481 cggcgattga gcatttcctg cctgactgcg ggatgaacaa ttgcatttaa agcgagacgt 2739541 ttttgttcat ttgtaaatac cagcgctcca agcttttttc tatctatatc gccatttgag 2739601 agcagtatgt cttcaccgaa ttcgtcaatg atttgccggt aggccggcat ccctttttct 2739661 accgcttgtt ttgcaatgat atctgcatct ataactgtta ttcctttttc aatcagcata 2739721 ttggctaccg tgcttttgcc gctagctatt cctcccgtta aaccaatgac taaggtcaag 2739781 agatccactc ctttttacaa tttccagagc ccaatcgtga ttaatagaag ccccggcaaa 2739841 aacgccattt tatcgatcca tttccactta gacagaaaat ggccggcatt gattccaatt 2739901 gatacaaaca gcgagctcat gattgccacg gcgatgctca tcacaatcgg cgaaaaaccg 2739961 agaatggctg cgcctatacc tgctccaaag gcatcaatcg ataaggcaaa tcccaataag 2740021 accgcctcaa ttccgttgat cacacccgat ttgtcgatat ccgcactcat gggttttctc 2740081 aaaatatgaa tcacaattcc taatgaccga acctctagat taagcagtgt tttttcatgc 2740141 aataggtatt ctttatcttt tgccggtttg aaaaattgat acagaaccca cgcaccgatt 2740201 ccaaccaata tcaaaccgcc aagcttctcc gtcacatata caggaaaaaa cttcgtgaga 2740261 aagcttccga tcagcatgga tataaacatg acagcaccgg aacagcaggc gataaccaaa 2740321 atcgctttaa acggtatttt catttttctc aatccgtacg taaatccgac tgaaaaactg 2740381 tccaagctga cagccaacgc cagcagcagt atagaaacca tttgcatatc cgtttcttcc 2740441 tttctgttgg tgctcttgta tcagatgtga aatgcccggg attcatcaca atcatatata 2740501 tgggaaagtg aaaaatccgt gtttcgaaaa tggcatcctt aatccagagt tactgatata 2740561 tgcaccgaca gcttggacaa tgaagcatta tgctactttt ttgtctggca ctttgcgcaa 2740621 aaatgcgtgc ctcttcctcc aacgacaatt ttcgaaatca tcgttccgca atttttgcat 2740681 ggctcgtctt tttttccgta cacaaaatgc tgcagctgga acattccgat ttccccttgg 2740741 gagttgatat atgaacggac tgtgcttccg cccgcatcaa tcgcctcctg cagagtgttt 2740801 ttgatttcag cgtgaagggt tttgattgtt ttatctgata attgatttgc ttttgtctcg 2740861 ggatggacac ccgctctgaa aagagcctca tccacataaa tgttcccgag tccaactacc 2740921 gttttttgat ccagtagggc agttttgaca gcgcggtttg ttttcgcaag ccggtctttt 2740981 aaatacgcac ttgtaaattc ttctgcatcc ggctccggcc ctaactgaga aagcgggagc 2741041 tcgcccgctt cttctcccgg tttaaataag tgcatggttc caaatttccg cacatccctg 2741101 taccggagct gggttccatc cgtcatcgtg aatatgacat gcacgtgttt atcgtcaggc 2741161 tcctcggctt gatgaagacc gtattttcct tccattcgaa ggtgagaaac cataacataa 2741221 tgatctaaat gaaacagtaa aaactttccc cgtcttccga tggactgtat cgtttctcct 2741281 gctagttttc gcgcaaattc ctccggttcg gcaggccgtt tgatgatatt cggccatctg 2741341 atctctaccg atttgattgt ttttcccttt acaagcccgg tcagagtgcg ccggaccgtc 2741401 tcaacctctg gtaattccgg cacatccatc acttcctatc tctgtttatt tcgcatcgta 2741461 ccaagatggg cctgatgcaa agtccacctt taacggcaca tctaatgcaa gcgcatgctc 2741521 catcacttca ggaacaagct tttcaagaat ttcaatttct tcctttggcg cctcaaaaat 2741581 caattcatcg tgtacttgaa gcagaagcct tgctttcaac tgtttttctt tcagcttggc 2741641 agccatgtca atcatggctt ttttgataat atcagcggcg cttccttgaa tcggcgtatt 2741701 catggccgtc cgctccgcaa aacttcggat attaaagttc cggctcgtca gctcagggat 2741761 gtagcggcgg cgatgcataa gcgttgttac gtatcctttt tgtttcgctt cctgtactga 2741821 atcttccatg tacgctttta cgccttggaa gctttccaga tagcggtcga taaatgctcc 2741881 cgcttccttc cgggtaatgc cgaggttctg tgacagaccg taatcgctga tcccgtaaac 2741941 aatgccaaag ttgaccgctt tcgcctggcg tctcatcgca gatgtcactt catccttagc 2742001 gacatggaac acatccattg ccgttttcgt gtgaatatcc atatcattag taaaagcttc 2742061 gatcagattt tcatcctttg aaatatgggc aagcacccgc agctcgattt gtgaataatc 2742121 ggctgcaaaa atgagccagt ctttttcaga cggcacaaaa gcttggcgaa ttttccgccc 2742181 ttcctcaagc ctgatcggaa tgttttgcag gttcggatca gtcgagctga gacggccagt 2742241 ttgcgttaag gcctggttaa atcgcgtgtg cactttatgc gaatccggtc tcgtcacctt 2742301 taaaagccct tcgatatatg ttgattgaag cttgccaatt tgtctgtact gtaaaatata 2742361 gtcgacaata tcatgcttgt cagccagctt ttcaagcaca tcggcagacg tagaatagcc 2742421 tgttttcgtt ttctttacga caggaaggcc gatcttttca aataagatga cgcctagctg 2742481 tttcggagaa ttgatgttaa acggctctcc cgcaatctca tggatttttt cttcatattc 2742541 cttcagcttc gcacccagtt cttcacccat ccgttttaaa cggtcaacat cgaccttgac 2742601 gccagttgat tccatttcgc caagaataag cgcaagaggc atttccagct cttcaaacag 2742661 ttcaagctgg tcgttgtttt ccagctcttg aacgagcttt tcccgaaggc tttgaatcgc 2742721 taacgctttt cggccaaggt gctcagacag tacgtcttct gacggcactg cccgttttgc 2742781 tccttttcca taaactgatt catcacttga aacgatatgc aggccgtaat ccttagccac 2742841 actcgcaacg tcgtcatatg aattgcccgg gttgatgata taagccgcaa ggagcgtatc 2742901 aaactcggct cctttcagct caatgccctg ccagcgcaaa gcgacaacgg cccgcttgct 2742961 gtcgaagacc catttcttct gctcgtcatt ttccacccat tctttaaaca cctcagactc 2743021 aacggcaatg tctttcggaa tgaaataagc tcccgtttca tttacgatcg aaaatccgag 2743081 gatcggctct tcatgataat tatcgccaat ctgttcaacg acaaatgcgg atggagaaac 2743141 caatatatcg cttgtcacgt ctgtgactgt tttgacatta atgtcttcca acgattgatc 2743201 ctgttctgct tctgcactgt cttctccaag ccgttcaaga agcgtgttga agccaagatc 2743261 tttaaagatg gcaatgacct gttcacgatt aaagccttga tattccaggc cggaaacaga 2743321 tacctcaatc ggagcatccg tcataattgt cgcaagctcc ttgctcatca atgcctgatc 2743381 cttaaactcc tcaagctttt ccttcaattt ctttccgctc acctcgtcaa tggactccag 2743441 cagcttttca acggaatcaa attgttttaa aagcttaatc gcagtctttt ctccgacgcc 2743501 gggcacaccc ggaatattat ctgaggaatc gcccatcaga cccttcatgt caatgatttg 2743561 ttcaggcgta agcccatatt tctctttgac atgctccggt gtgtaaaatt caacatcggt 2743621 aattcccttt ctcgtaatgg caactgtcgt tttgtccgtt gccagctggg ttaaatcctt 2743681 atctcctgag aaaaccttaa cttcaaatcc gtctttttca gccgatttgg ccagtgtgcc 2743741 gataatatca tccgcttcat attgttccag ttcatagcgg ctgatctggt aggcatccag 2743801 cagctcgcgg ataaacggca tttgttcgga aagctcaggc ggggttttct gtctgccgcc 2743861 tttatattct ttaaatgtgc cgtgacgaaa tgttgttttc ccggcatcaa acgcaaccag 2743921 catgtgcgtc ggtttttcat cctcaagcat tttcatcaaa atcatcgcaa agccgtatac 2743981 agcattcgta tgaacacctt tatcattgct taacagcggc aatgcaaaaa acgcccggta 2744041 agccagactg tttccgtcta caagcactaa tttttttcgt tccgtcattc aatttcctcc 2744101 taagaagcct caggcttcca ttcatctctt acatagtcat tagctcctct tattttaaca 2744161 aagttcaatt tgaaaggaaa atacgtgaac tataagagaa gacacaaaaa aggacgggaa 2744221 cacaaatagg ttcccgccgt caaaattggc tccttggatg aaggggttct actacatcct 2744281 accagcatag gtttaacagt gcatgaagat attgttaaac ctttgtaaac attaggcgga 2744341 cttttcagcg gcccgtttca gcgtcacggt aaagacagtt ccccgtccaa gctcgcttgt 2744401 gacatcaatt ttcccttcat gagcctctat taaatgcttg acaatcgcta ggcccagccc 2744461 ggttccgccc gaatttctgc ttctgtcttt atctacacgg taaaagcgtt caaagatgcg 2744521 cggaatttct tctttctgaa ttccgattcc agaatcggca acctcaatct gaatgtcttt 2744581 ttctctgggc tttacattga tagccacgga gcccccctca ggcgtgtagg ttaatgcatt 2744641 gtttacgaga ttaagaaata cctgtttcag cctgtacggg tcaccagata catattgagg 2744701 gtctttcggg acattcaggt gcaaggagat gcctttctca tccgccttat gcttcagaag 2744761 cgtttcaatc tcaccaagca ttttggccgg ctcaaacgtt tcgatactga gcgtgaaatt 2744821 ttgctgctcg atttttgaga gatcgagcaa atcctgaacc aaagactgaa gcctttcgct 2744881 ttccttaaga ataatagaga gaaattcaga aagcgcctct ttgtcttcca tcgccccgtc 2744941 caataacgtc tccgtaaacc cttttatgga cgtaatcggt gttttcagct catgagaaac 2745001 attggccaca aaatccttcc tcatctgctc taatttcttc gtttccgtca tgtcatggaa 2745061 aacgagcaca attcctttcc attcatcgtc cggccccata atcggaacgc cgtccacttc 2745121 aaaataacgc cgttctattt tgatcggcag tcttaacagc ttgcatttct ttgtctccgt 2745181 cataaaaatg tcttcgacaa gctggatcac ttcttcatgt tcaaatgcat cgtgataaag 2745241 acggcgcagc atatgattcg gattgatatg aaactgcttg gcgtaagacc tgtttacgag 2745301 attaataaag cctcttccgt cgatcataat cagcccggag ccaatgtttt caatgactgt 2745361 cagcagccga tcccgctgca tttcctgcgt tcgcgtcatt tccatcagat caatggcaag 2745421 gctgttcatc gcatgtccta gcttatcaga acgcctaata tagccgccgt acgtccgtgc 2745481 atcgtagttg cccttagaga gttctgtggc tacatttgtc gctgactcaa ttgacctttt 2745541 ataacgtgag gtcatgctgg aataaaaata aacaatgacg ataaatgcgg tacaaagact 2745601 ggccgtcagc atcccccaca attcgccttt taagccgtcg cttttttcag aggcggaaag 2745661 cagcacatat cctgtttttt caccttcgct tctaagtgaa agtccgtaat aaagcttgtt 2745721 atctgttgtt gacagaatac cctcatggcc agaaacaagc gcctgcacct tttgggaatc 2745781 agccgatcta ccgtttgacc catacagcac cttaccgtct gtatcgataa cggatgcgct 2745841 cacatcaagc gcgccgcctg catctttaat gattttctca tttgcttgat tattcagatt 2745901 gccggcatca agaagcgaag ccaagtattt tgcttctttt tcaatgtgtt cctctgcttt 2745961 cctttgatca gatgtttcaa aaagctgctg taaaaacagc ccgaggacac aaaacaccag 2746021 aatcatacag acaacgaata cagaaaaaag gcgcacacgg tatttattca ttcatttttg 2746081 gctcctccag tttatacccc aatcccctaa tcgttttaat gtagatcggt tttttggtat 2746141 tgttttcaat tttgtcgcga agatggctga tgtgcacatc aacaattctc gtatctccgg 2746201 caaaatcata attccagact gcgctcagca gcaggtctct tgtcagaact ctgcctttat 2746261 gtctgcctaa atagagcagc agttcgaatt ctttcggtgt cagttcaagc tgactttctt 2746321 taaagtacgc ttcataatga tcaggcagga ttttcagatc gccgattacg atctggcctt 2746381 ccatttcatc gttcttcatc tcactagagg gcgcagctat ttccgaacgc cttaaaatcg 2746441 ctttgactct cgcatttact tcccttggac tgaacggctt ggtcatataa tcatcagcac 2746501 cgagctccag ccctaatact ttgtcgaatt cctcatcctt cgctgtcagc attaaaatgg 2746561 gaaacatcag tttttgctgt ctcagctgct tgcatacttc gattccgtcc aattttggaa 2746621 gcatcacatc aagcacaatc aaatcaggtt tctctgtttc cgcttttttg agtgcttctt 2746681 ccccatccga ggcggtaatg acatcatagc ctgaccgttc caaattgtac tgtaaaagag 2746741 taacaataga ttcttcatca tccacaacta aaattttctt gttcatgctg tgcctccagt 2746801 attataattc cccgacatcc tatttctcta ttttatgtca tcttaacatg tttcatgatt 2746861 ttattttagc gaaagcagga cattccgaca attcgccttt tacatcattt ttaaaagaaa 2746921 taaagacgtt tatgatagcg ctttcattta tagtaaaaag agaaaggctg tattaagcaa 2746981 gcctttctct ctttttatta ggataatact ttcatgacat ttttgacaga ttcaactgat 2747041 ttattcagct gcgctctttc atagtctgtc agttcaagtt caatgatttg ctcaagaccg 2747101 ttgccgccta caattgtagg aacaccaagg tagatgcctt catagccgta ttccccttca 2747161 agataagcaa ttgtaggaag gacgcggcgc tgatctttca agatcgcttc gaccatttct 2747221 gtcagagaag ccgcaggcgc ataatacgcg cttccgtttc caagaagatt cacgatttcg 2747281 cctccgcctt ttctagtgcg ctccacaatt gcgtcaatcc gttctttcgg aataagagtt 2747341 tcaagcggga taccgccagc ataagaataa cgcacaagcg gaaccatatc gtcaccgtgt 2747401 ccgccgagta cgaaaccagt cacatctttc actgacaggt ttaattcctc tgccacaaat 2747461 gttctgaatc ttgccgtatc aagcacacct gactggccga ttacacgctc tttagggaag 2747521 cctgattctt tgtacaccgc gtatgtcatt gcatcaacag gatttgtcag caccacaata 2747581 atagagtcag gagaatattt cacgatttcc tgcgtaacgc ttctcataat cttttcgttt 2747641 gtagagacca gatcatctct gctcatacca ggttttcttg cgataccggc tgtaatgaca 2747701 acaatgtcag agccggctgt atcctcgtaa ttggatgttc ccgtaatttt tgcgtcaaag 2747761 ccttgaaccg ggcttgcttc aagcatatca agcgcttttc cctttgtcgg gttctccaat 2747821 tgcggaatgt caacaagaac aacgtctgcc agctcttttt gagcgattaa aaatgcagtt 2747881 gtagctccgg taaaacctgc tccgataaca gaaacttttt tacgagtatt tcccatgtct 2747941 ctcttctcct ttatggctag ttttaggctt tttccttgct tagtccatgt ttttgatcag 2748001 ttcttctccg aactctgaac atttcacttc agtcgccccg tccattaatc tggcaaaatc 2748061 gtaagttacg actttagaag cgattgtttt ttccatagat ttgataacca aatcagccgc 2748121 ttcgttccat cctaaatgct caagaagcag aacgcctgaa agaataactg aagatgggtt 2748181 tactttatca aggcctgcat atttaggagc cgttccgtgc gtcgcctcga aaatcgcatg 2748241 tcctgtttcg tagttgatgt tcgctccagg agcaatgccg attccgccga cttgcgcagc 2748301 aagagcatca gaaatgtaat ctccgttcaa gttcattgtc gcaacgacat caaactcgtt 2748361 tggacgcgtt aagatctgct gaaggaaaat gtcagcaatg ctgtctttga taatgatttt 2748421 tcctgctgct tccgcttcgc tttgcgcttt gttggcagcg tcttttcctt gttcttcagc 2748481 aatgcggtca tattgagccc atgtgaagac tttatctccg tattcttttt cagcaagttc 2748541 atagccccag tttttgaagg cgccttctgt gaacttcatg atgtttcctt tgtgaacaag 2748601 tgttacagat ttgcggccat gctcgatcgc ataatcaatg gcagctctga ccaagcggct 2748661 tgttccttct tctgaaacag gcttaatgcc gatacctgat gtctcaggga aacggatttt 2748721 attgacgttt aactcatttt gaaggaagct gataagcttt tgcacttctt cagagccttt 2748781 tgcatactcg atgcctgcgt aaatatcttc tgtattttca cggaagatga ccatatcagt 2748841 atcttcaggg cgttttaccg gtgacggcac tccagtaaag tatcttacag gtcttaagca 2748901 gacgaatagg tcaagctctt gtctgagcgc tacgttcaaa gaacggatac cgccgccgac 2748961 aggtgtcgtt aacgggcctt taatcgcgat gaaatattcg cggatcacat ctaatgtttc 2749021 agcagggagc cactcacctg ttttattata agccttttct ccggcgtaaa cttctttcca 2749081 tgtaattttc ttttcgcctt tgtatgcttt ttctactgct gcttccaaaa ccttcgaagc 2749141 cgcgttccaa atatcaggac cggttccgtc tccttcgata aatgggataa tcgggttgtt 2749201 tggtacgttt aatactccgt tagagactgt aattttttca ccttgtgcca caataaaaac 2749261 ctcccagtat gtaattcata tttagaaaac attttatttt tcttatatag aaaataaaat 2749321 gatttttcct aacattcaat ttaaagtgta acccaatttt gatgtctgaa caagaggcta 2749381 acctcattga cgcaagccag cctccaatgg ttctttaggc tctttcttca atcggaacga 2749441 atttttgttt gtcagggcct gtgtaatctg cccgcgggcg gatcagacgg ttgttgtcat 2749501 actgctcaag aatatgagcg agccagccgg acattctgct tacagcaaaa atcggtgtaa 2749561 acaaatcatg gtcaataccg aggctgtgat atacagaagc cgaatagaaa tcaacgttag 2749621 gcggaagctt tttctctgat gtgacgatgt cttctatacg aatcgacatc tcataccatt 2749681 tgctttcgcc tgtcaggttg gtcaggcgct tgctcatttc tttcagatgc ttcgcgcgcg 2749741 gatcaccatg cttatacaca cggtggccga atcccatgat tttttctttc ttttcaagtt 2749801 tagcgcggat gtacggctca gcgttttcca cttcaccgat ttctgtcagc attttcataa 2749861 cgccttcatt cgctccgccg tgaagaggcc ctttcagcgc gccgattgct gcagtaatgc 2749921 ctgaatagat gtcagaaagt gttgcgacgc agaccctcgc tgtgaacgtt gacgcgttca 2749981 gctcatggtc agcatgtaaa atcaatgctt tgttgaaggc ttcaacttca attggtgaag 2750041 gctcttcacc gtttaatgtg taaagaaaat tctccgcaat accgtaatct tctctcggtt 2750101 caacaggctc aagacccttg cgaattctgg aaaacgctgc aaccaggcca ggcacctttg 2750161 cctgaaggcg gatcgccttt ctgtagttgg cttccgggtt catggtatca gcctcgctgt 2750221 caagcaggcc tagtaatgaa attgctgtcc gaagagcagc catgggatga acattttcga 2750281 gggaataaga tttgaagtgc tcaataattt cttgcggaac ggcagcttcc tttgcaagct 2750341 gctgctttaa ctcttcaagc tcttttttgt ttggcagcct tagatgccaa agcaagtaga 2750401 tgatttcttc aaaacttgca ttctctgtca aatcatcgat atcatacccc acatatgtaa 2750461 gggtatcatc aataatagaa ctaacagatg atgttgttgc tacaacccct tcaagaccgc 2750521 gtgtcgctgt catatataac atctcctttt caataaattt cccctttaag agtgttgtaa 2750581 aaacatgagg cttacttaaa aagcacgatg caagtatttc tctcccccaa aaagaaaatg 2750641 cttacatttt actggctgct ggaactaaaa ccctttgctt ttgaaagaac ataacaaatt 2750701 tttataagct tatttaagtt taagcctatt ctcattataa acaataatca gacatttgtt 2750761 aaatgtttac ctataatttt ttttttccat tctgtgattt ccccgaaaaa acgcctttat 2750821 ttgcgggttt ttgcataaaa aaaagcggct ttaaggccgc ttttttttat gaagtgaaca 2750881 gttttacgat ctgcatggct aaataagcaa tccccgctcc gatcagcggc cccaccgcaa 2750941 ctcctccaaa aagcgcgact gcaagaatgg tcccgatcac gagagcagtt gtaatatgcg 2751001 gatcattttc aagcagggtc aggccgtttt ttgcaatcag cgccactgcg atccccgctc 2751061 caagggcgat ccatgcgtag gaagaccgca ttgcttctcc aagctgctta aatccgattt 2751121 ctcccgtggc aatcgggaca agaacggcga tggtaataat ggtcacaccc cagttaatgc 2751181 cttttgactg gatggtcgga aataatttct gatcaagccc aacgattttg atgatcaaaa 2751241 ggacggatac agcaaagagc aatgattggt tttttgcgat aagtgcgata gccaagagta 2751301 aaattaaaaa taaattcgct tgtgtaaaca catgccatcc ctcctttaag atgaatgtat 2751361 tcatattcag ccgcagcgtg aatacatata aaaaatagga catgctgacg agaggaggac 2751421 cgtttttgtg aatcaatctt atatcactat ttttttcaga accctctttg tcatatcaat 2751481 gaccgcaggg tcgatagctg cggcctatta ttcgtttccg ttaacttatc cgttcctgat 2751541 cgcccttatt ctatcttcag tgattcatcc tgttgtcgat tatttggaca aagtgacagg 2751601 attcccccga acgataaatg ttctgggcgt tcttgctttt tttctgctcg cagccttcgg 2751661 cgtgctcacc attctggtag ccgaaatcgt aacgggaaca gcctatctag caaaaacgct 2751721 gcctccgcat atcagcacgt ttatttcata ttgcgaaaaa ttgtttacca ctcatattca 2751781 gccgctctat aacgagttaa ctcttttgtt tcaagaattg gaaacgaacc agcaggcttc 2751841 catcgtcact catatccaga cactcggtga ttctgccgct aaaaatgccg ggctcctgct 2751901 gtcccacatt ctagagatga tcccgagatt tttcgctctt cttcccaata cggcggcggt 2751961 tctgattttt tctcttctgg caaccttttt tatgacaaag gattggcata agctgaaagc 2752021 catgcttgtt ttaattctgc cggatcgtgt gacagctaac agcaaagcaa tcagcagcga 2752081 attaaaaaaa gcaatgactg gttttatcaa agcacaagcc gtcctcgttt tcatcacgat 2752141 ggtgattgta tttatcggcc tttctctctt aaaggttgaa cacgccgcaa caattgcttt 2752201 tttaatcggg cttgtagatc ttctccctta cttaggtgcc ggctccgtat ttgtgccctg 2752261 gattttgtat ttatcgatta cgggccagct gccccaagca atcggaattg gtatcctgta 2752321 cctcgtcgtt cttattcagc ggcagctgac agagcccaag atactaagta aatctatcgg 2752381 gatcgatccg ctggcaacac tcatcgccct gtttgccggc tttaaattat tcgggttttt 2752441 aggactgatt gcgggaccgg ctgtactcgt catcatccaa gctttcatca caacaggcgc 2752501 attaaaagaa atatggtcct atatcaccgt tcagcaaaaa taaaacggca gccgtttttt 2752561 catggctgcc gttttttatt tgatgatgat ccgcttattc ttcgacattc ctctcagcca 2752621 tttgaacaga atcggcttac accagccgcg ggtaaacggg ataagaagac aggcgccggc 2752681 caaatctgat aaaaagcccg gaagcatcag caatagaccg ccaatgaaaa tgcacagacc 2752741 gtcagcaatc gcttctcccg gcattttgcc atattgaaga tcacgctgaa ccttataata 2752801 cacttcggtt ccttgttttt ttgcagctgc tgcgccgata atgccagtca gaatcatgaa 2752861 tagaactgtc ggcaaaatac caatcagatt tcctaaaaat aggaatatac cgatttctat 2752921 tgccggaaac acaataaaaa gcaaaaacaa aaatctcata tccaagcccc ccacacgtgt 2752981 aacacgttct gttcaacaaa aggcatgata aagagaaaag gaagggattc cccttccatt 2753041 ttcacctgta attaaagaac gctcgcacgg ccttgataga ctgcgcctct ggaagcgtca 2753101 actgtaatat cctggccatc tgtcaaaata gatgtcgcat tttccagacc cacgataacc 2753161 gggatgccaa ggcttaatcc gactaccgca gcatggctag tcaaaccgcc ttcttctgta 2753221 ataagagcag acgctttttc aagggatgca atcatatcac ggtcagtgct tttggtaaca 2753281 agtaccgcac cgtcagtcat tttttgctca gcttcttttg cattttgtgc aacgacaacc 2753341 ggaccgtaag ctgatttgcg tccaatgcct tggcctttag cgatgatatc gccgacagta 2753401 tgaaccttca ttaagttcgt agtgccggac tcaccgacag tgccagctgt aataacgata 2753461 agatcgccgt gttttacaat tccgctgttc aatgattttt ggacagcatc ctcaagcatc 2753521 tcatctgttg agctcgcatt ttggccgctt tccgcgaata cgccagatac gagggcaagc 2753581 tttctggaaa tagagtcatt tacagtaacc gcaacaatcg gagcctgcgg acggtatttt 2753641 gcaatcatac gtgctgtatg gccgctttct gtcggcgtta cgatcgcagc agcattcagg 2753701 ttaatcgccg tatgtgcgac agattgtcca attgcgtctg taattgtcat gcccacttgg 2753761 tctctgcgtt ttgagagaat ttctttataa tttaatgctt cttcagaacg ggacgcgatg 2753821 ttatgcattg tttgaactgc ttcaaccggg taacttccgg cagcagtttc accagaaagc 2753881 atgatcgcat ctgttccgtc gaagatcgcg tttgcaacgt cacttgcttc cgcacgagtc 2753941 ggacgcgggt tgcgctgcat gctgtcaagc atttgtgtcg ctgtaataac aggtttgccc 2754001 agcgcgttgc attttttgat cagttctttt tgcacaagcg gcacttcttc agctggaatt 2754061 tccacaccta agtctccgcg tgcaaccatt aagccgtcag acacttcgag aatcgcatcg 2754121 atgttgtcaa cgccctcttg gttttcgatt ttagggatga tttgaatatc ctgagcgttg 2754181 tgctcttcaa gaagctcacg gatttcgagc acatccgtag aacgtcgaat gaaagatggt 2754241 gcgatgaagt ctactccttg ctcaataccg aaaacgatgt ctcgcgcatc cttttcagta 2754301 atccccggaa gattgacact tacgcccggt acgttaacac cttttttatt tttgagtgtt 2754361 ccgttgttta atacttttgt tttgatttcg cgtttagcgg catctacatc aagtacctca 2754421 agaccgataa ggccgtcatc taacagaatc gttgaacctt gttcaacgtc atggactaaa 2754481 ccttcatatg tcactgaaat tttatctgtt gttcctacaa cctcgtccat tgaaataatg 2754541 agctctttgc ctgtttcaag ctcaataccg ccgttttcca ttgtatgtgt gcggatttca 2754601 ggaccttttg tatcaagcag aattccaacg ttcttgccaa gttttttact tgcttcgcgg 2754661 atatttttaa ttcttgcacc gtgctcctca aaatctccgt gagaaaagtt taatcgagcc 2754721 acgttcattc ctgactccat taatttcgta agcatttcaa tactttcact tgccggaccg 2754781 atggtacaaa caattttagt ttttctcatt tggttcactt ccttctgaaa tcttcagcct 2754841 tcagctgtac attagataga cagttctttt gaaagctgat acatgttttg ctcaactgtg 2754901 tgttttgtct caagtatttc tataatatca tggtctacaa gcttattgtt ttgtatacct 2754961 acacagcgtc cgccttttcc ttcaagcagc agttcaactg catatgcgcc gagacggctt 2755021 gccaacacac ggtcagcagc actcggagaa cctccgcgct ggatatggcc caatacagat 2755081 accctagttt caagatttgt ttcttcttca atgcgtttcc cgaattcaac accgctgcct 2755141 acaccttcgg caacaataat aatactgtgc ttcttgccgc gttcgtggcc gcgttttaag 2755201 cgggcaatga tttcgtgcat gtcatagtct gcctcaggga ttaagatcga ttctgcgccc 2755261 cctgcaagac cggcccacaa tgcgatatcg ccggcatgac ggcccattac ttcgattaca 2755321 tatgtacgtt catgagaagt cgctgtatcg cgaatcttat caattgcgtc aattactgta 2755381 tttaaagctg tatcgaaacc gattgtaaaa tcagtgcccg gaatgtcatt atcaattgta 2755441 cccggtacac ctacacatgg aaacccgtgt tccgttaatt ttttcgcacc catataggaa 2755501 ccgtctccac cgataacaac aaggccttca ataccaagct tcttcaagtt tgctatccct 2755561 ttttcacggc cttcaactgt tttgaattca ggacatctcg ccgtataaag cttagtccct 2755621 ccacgatgta taatatcgcc tactgatccg agttcaagct tttcaatctt tccgctgatc 2755681 aatcccgcgt atccgttgta aataccgtaa acttcaacgt catgatagat cgcttttctg 2755741 actactgcgc gaactgctgc gttcattccc ggggaatccc cgccgctcgt taatacccct 2755801 attcgtttca ttctccattc acctcagcaa catatatgat taaacataac atgatcattg 2755861 ccctaaaaac aatgaaaagg gatctccatc ctccctatga aaccttacct attatacaat 2755921 taaataaatt gtttttaaat aaaatttaag gaatgtcaca aaaaataaac gtgagccaaa 2755981 ggcttcacgt ttatttagtt taccccgata tattgatctt caaccgagac tttgccaatt 2756041 gctttatatt tttcataacg ctgctgaact aattcttctt cgctcagctt cagtaaagtt 2756101 tttaacgatt gtttaagggt ttcgtccata tagcttgcct gcagcttcac atcatggtgc 2756161 gctccgcctt ttacttcttt aatcatatga tctataatac ctaattcttt taaatccggc 2756221 gcagtgattt tcattgtttc tgctgctttt ttagcaagac tggagtcctt ccataaaagt 2756281 gccgcggcac cttccggaga aataacagaa taagtagagt tttccagcat atgcaagtga 2756341 ttgcctacac ccagaccaag ggctccgccg cttccgcctt caccaatgac gatgcagata 2756401 acaggcactc gaaggccggc catctcaaac aggtttttgg caatagcttc actttgtcct 2756461 ctttcttcag ctgctcgtcc agggtatgcc cccttcgtat caataaaaca gataattggt 2756521 ctgttaaatt tgtcagcctg tttcatcaga cgaagcgctt ttctgtagcc ttctggatgc 2756581 ggcatcccaa aattgcggac taggttttcc ttcgtgtctt tgccgcgctg atgcccgatt 2756641 accgttacag ggaggccgtg gaacttcgca atcccgccga caatggcttc atcgtccccg 2756701 tacgctctgt ctccgtgaca ttcaaaaaag tcggtaaaca ggtgttcgat ataatcaaga 2756761 gttgtcggac ggtccgccag acgcgcgatt tgaacccggt cccacggctt caaatttttg 2756821 taaatatcat cctgaagctt agcgagacgg tcttcgagcc gttcgatttc cgcacttaga 2756881 tccatatcgg aatcttgggt gaattttttt agttcggcga ttttggtttg cagttcaatc 2756941 accggttttt caaattctaa tcttggagcc actcaatgtc acctcctgtt tgatgcatat 2757001 ccagcagatt ttctaacgtt tttttcatat cgtcgcgatg aataaccgca tcaagctgtc 2757061 catgttttaa taaaaactca gccgtttgga agtcctcagg cagtttttct cctattgtct 2757121 gttcaataat ccgtcttccg gcaaaaccga tcagcgcgcc aggctcagcg aaattgtaat 2757181 cgccaaggga tgcaaagctt gctgatacgc ccccggtagt cggatgcgtc attactgaaa 2757241 taataagacc ctgttcttca ctgaacagtt ttaacgcaga gcttgtcttt gccatctgca 2757301 tcaaacttaa tacgccttcc tgcattctag caccgcctga agccgtaaaa ataataaacg 2757361 gaactttatc agcttttgct ttttcaatcg caagcgtgat tttttcaccg acgactgaac 2757421 ccatgctgcc cattctgaat gaagagtcca tgacggcgac aacagccggg tgtccgccga 2757481 tggtgccctt gcctgtcaca acagcctcgt ttaaggatgt tttctcgcga tctttttcaa 2757541 gcttttccag atatcccggg aaaccaagcg gattttccga gagcattccc tgattaaatt 2757601 cctcaaagga ttgttcatcc atcaagcttt cgatacgctg ttttgcgttc attgggaaat 2757661 gataatcgca gttcatgcat acccgcatat ttttatccaa ctctttagtg agcatgattt 2757721 ttttacactt aggacatttt gtcataatgc cttccggaac atcgtgcttc gcttgatcag 2757781 acggtacgga agcatacttt ttctttttcg tgaatatatc ctttaacaaa tgattacctc 2757841 ccttttgtga agggttctct tcaccgcatg tcatcaaaca gatagacttg ctaataactt 2757901 taccgaaact attgtacttt ttttgtcaaa cgctgtcatc ctcaattcga caacttttta 2757961 ttcgatgacg tgctcggaaa ggcttgtatg aaatcagata aggtgttgaa acgacaaggt 2758021 tgacagcgca ttcaaaaata atgttaaacc cggctgaaat ttttttaagg ctaaccccct 2758081 aaaaaaattt cagccgtcag tttaacttga gaacagcgcg ccggtctccg ccaacgcgct 2758141 gccatttttg gaatgaatta aaattattca ccaataatcg taagttttct tgttttttct 2758201 gcgacttcct cagggtcaac agtgattctt gcaacacctg tttccatcgc agcttttgcc 2758261 acagccttcg caacagcagg cgcaacacgt ttatcaaacg gtgcagggat gacatagtct 2758321 gcgctaagct catcttctga aaccagtgaa gcaatggctt caaccgctgc gattttcatt 2758381 tcctcgttaa tatgagtggc acgcacatca agcgctccgc ggaaaatacc agggaatgca 2758441 agaacattgt ttacttggtt cgggaagtca gaacggccag ttccgacaac gcttgctccg 2758501 gcttcacgcg catcttccgg catgatttcc ggatttggat ttgccattgc aaagataatc 2758561 ggatcttttg ccatgctttg aaccatttct tttgttaacg cgcctgctac agagacaccg 2758621 ataaatacgt cagcatcaac gataacatct ttcagagaac cgtctttgcg atcttggttc 2758681 gtgaacttcg ccacttcatt tttgacatcg ttcatgccgt tcgggcgccc ttcataaatg 2758741 gcccctttgg aatcgcacat cacaatgtcg cgaacgccat aatgatgaag aagcttgata 2758801 atcgcaatgc cagccgcacc cgcgccgttt gcgacaactt taatggatga catggatttt 2758861 ccagacagtt tcagcgcgtt cacaagacct gctacggtta caatggcagt accgtgctga 2758921 tcatcatgga aaaccgggat gtttgtttct tttttgaggc gctcttcaat gataaagcag 2758981 tttggcgctg caatatcttc aaggttgacg ccgccaaatg tcggttccag caattttaca 2759041 gtttcaacga ttttatcaac atcgtttgtg tttaaagcaa tcgggaacgc atctacgccc 2759101 gcaaagcttt tgaaaagaac tgctttccct tccataacag gaagcgccgc ttcagggccg 2759161 atgtttccaa ggccaagcac agctgtaccg tcagttacaa ctgctaccat gttccccttc 2759221 attgtataat catatacttt gttaatgtct tcatgaatat ccttacacgg ttctgcaaca 2759281 cccggagaat acgcgaggct taaatctttc gcatttctga cctctacttt tgatttagac 2759341 tccagtttcc cctggttgac tttatgcagg tgtaatgctt cttctcttaa tgacattctc 2759401 ctaaacactc cttatggata ttttttgatt cgtatactgc tgcgttgatt gctgcattct 2759461 gcggagtaaa tctatctgaa tatttaaaca ggatcacata attgctccaa ttgtataaca 2759521 aaaagcgaat cgttaccact gttttaaaac gacgtttttt tgacccaaca gctcttttaa 2759581 gcgatataac acctggtgat ctgcattgat atggaacgac tcaggtagct taatcgtctg 2759641 tttttgcctt tcataataga gataaacgcc tgtttcccct ttatgctcca gcaaaatgcg 2759701 cttaatcttt gccaggatct cctggctgtg ctgactgctt tctattttta tataaaccga 2759761 tggcgctttt tctgcatcca tatcttctaa taattctgcc cgggacatga tgaattggat 2759821 cttatcttgt ctaacttcac atttccccgc agtgaacaaa agagcgcctt ctcttaaaac 2759881 gggagaaagc tgtctgaatt gttcagggaa gactacggct tccatctcgc cggtttcatc 2759941 actgagcgtt aaaaacgcca tgttttgacc tgttttcgtc cgaatcgttt tgatcttcga 2760001 cagcagaacg cctagtgaaa gctgcctttt gactgcccgc tgagcctgca gaatggagac 2760061 tgctccttgc gcagtgagct gttttcggaa ggcggagagg ggatgatttg aaaaataaat 2760121 gccaagcgtt tccttttcaa acgcaagtaa atccaccaga ggaagctcct ccgtctccac 2760181 atacttcggc ttaattgaaa acgattcatc taaaaacaat cccatttggt catcgtccgc 2760241 ggcgaatagc tcagcatgtt ccaaagcaac atcaatggat gcgagcagcg tggcccggtt 2760301 ttggccgaat tcgtccatcg caccagaaaa gataagtgct tcaagcattt tgcgatttac 2760361 gctttttgac ggcacgcgaa agcagaaatc gaaaagatct tcaaatggtt tctcttttct 2760421 tgctttatat atatctttga ctgctgagac gcctacactt tttatcgcgc ggaggctgta 2760481 tctgacagat ccgttttcaa ctgtaaacgg aaaactgctt ttattcactg acggaggaag 2760541 gatacgaatc ccgctcccct ttgcttcgta aagatattga gagattttat cctcattgcc 2760601 aatgacgctt gtcagcaatc cgcacataaa atataacgga taatgagctt tcaaatacgc 2760661 aagctggcac ccgatcatgc tgtatgccac cgcatggctt ctgttaaagc catagtttgc 2760721 gaatttgacg attaaatcgt agacctcatt tgcagtgtct acagaatact ccttttttaa 2760781 gcacccttca acaaaatggc ttcgctctct gtccaggatt tcttttttct ttttgctgac 2760841 cgcccttctc aataggtccg cttcgcctaa agaaaacccc gccatacggg aagcaatcat 2760901 cataatttgt tcctgataca caatgacgcc atatgtatct tccaaaatgc tccttaaatc 2760961 ttcatgagga tagtgaacag gcgcccgacc gtgtttacgg tcgataaata acggaatatt 2761021 ttccatcgga cccggccggt acagtgcatt gaccgccaca atatcttcta ggcccgaagg 2761081 tttcagccgt ttcaagacgc ttctcatccc tgcagattca agctggaaaa tgcctgtcgt 2761141 atcccctttt gacagcaagg agaacgtttt gtcatcgctg taggaaatac ttgaaaggtc 2761201 tattttaata ttttcttctt tttcaatcat tgaagtgatg gattcaataa gtgtcagatt 2761261 cctcaaacct aagaaatcca tttttaaaag gcccaagtct tcaagatggt ccatcgcgta 2761321 ttgcgttaaa tagatccctt catgcccttc ttgaagcgga acaacatctg ttaacggttc 2761381 ttcactcagg acaacgcccg ctgcgtgggt tgatgcatgc cttggcagcc cttctatttt 2761441 ccgggcaatt gaatagactt gctgaagcag gcttgactcc cgaagccgct tatccagctg 2761501 cggtgactgc tgtctcgctt catccagcgt cattcccggt cttgaaggaa tgagttttgc 2761561 aagctgatct gcctccttcg ggctgacgcc gaatactctg ccgacgtccc ggagcgccgc 2761621 ctttgccgca agtgttccaa aggtgataat ctgtgcgacg tgcattgcac cgtatttctg 2761681 ctgaacatat tgaatgactt catcccttct agtatcggga aagtcaatat caatatccgg 2761741 catgctgacg cgttcgggat ttaaaaatct ttcaaacaga aggtgatgct taatcgggtc 2761801 aacatctgtg atatacagca catatgccac aagagaaccc gccgcagaac cccttcccgg 2761861 tcctgtaaca atcccttttt catgggcgtg cttcataaaa tcccacacga tcagaaagta 2761921 atcgctgaac ttcatccgct tgatgacatc aagctcatat tgaagacggc gaaggtatcg 2761981 ttcatcaggc ttgccgaaac ggctgcggag tccctccata cagatatccg ttaaataatc 2762041 atcagcggac gttccgtctg gggtcggaaa agacggtaga cgggtctgcc cgagactgac 2762101 gtcaacccgg cattgttccg cgatctctac agaagcttgc agtgcctcgg gatgctctcg 2762161 ataaatgttt tgcatttctt cgagtggttt caaatcgaga tcaggcaaat cttcagcggg 2762221 tgcatccgtc agtttttccc ccgctttaat cgctttcaaa caacggtagg cagccttatc 2762281 ttccttcctt atgtaatgca catcgcctgt ggccgtaaca gggatacccg tttcttctga 2762341 cagctttaga atctgctcag acaagacttg attcccttta aaaggctgat aggagaaata 2762401 aaaagctccc tttccgaata tagactgaaa ttccagcgag gcttgagcag cctgttcgaa 2762461 cagccctcct tcaagaagcg tttcaatata tcctttttcg ccgggcgtta ttgcgataat 2762521 cccttctcga taactgtgaa gccatttcgg cttcagtccg ccttttgatt tagattgcag 2762581 aacgctgctg attttcagca ggttttgata gcctgtattc gattttgcca gcaggacgag 2762641 cgggtatgct tcaagctcgc tgtcatctgt aaaaacagaa gccgtcaaac cgattattgg 2762701 gttgatccct ctcgccttgc aagctttata aaattgaata gctccgtaca tgacatgatc 2762761 atctgtcagc gccaaagacg catatccgag cctgtcagct tcactgacga gttcttccac 2762821 agccgcggcg ctgtttagca ggctataccc gctatgcact tgcaggtgaa caaaagacat 2762881 gctatcacct ctttctcatt acgatccatt tcttccttca ttataaggcc ggtttccaaa 2762941 agaaacaaat gttctttttt gactcatcat catacttgtc ctgaaagctc aatatgatat 2763001 aaaaggtgag gtgataaaga tggatcagga agcaggattt atggtgaatt ttatcaatag 2763061 ctacttcatt gcgttagggg tgctgatcgg gggcgcactc atcggagggc tcggagcata 2763121 cttggcaggc gaacccccgc ttacagccat tacaaagctt gccaaccggt taaaaatatg 2763181 ggcgcttgtc gcagctatcg gaggcacctt tgatgcggta tacagctttg aacgcggcat 2763241 actcgaaggc aatacgagag atatctttaa acagcttctt ttaattattt cggccatggg 2763301 gggcgcgcaa agcggctggc ttattatatc atggctgacc caggagcatc tttcttcatg 2763361 agggtccccc agcattacaa aaaaccggga tggcagcgtt ttttcgcggg aatgatgtgc 2763421 ggagccgtaa tcagctggtt ctttttcctg tttacttacg gaacattcca agaggagcag 2763481 gtcagcctca tcgaaaagca aaaagagcat gtaaaagact tgaacaatca aatttcgatc 2763541 tatcaggaag acctccataa actgaatgaa gataataaaa gaaaactgct gattcaaagc 2763601 gtcagcgtca aattgctgaa tggggataaa tataaaatat cacagccgga taaaacgaaa 2763661 ttcgaggagc atgtaaagga tgatatttca gaggtgatta caaaagacat agagagcgtc 2763721 tatcaaacaa aggatctctt gaagcggaca attgaaaata aagtctatat gatcaatgaa 2763781 aaaaaatacg aggcaaccgt cagagaattg attatttata cgaggctgac agtggaactt 2763841 gaaatttctt tcgccacata attatggatt ttttttaaat tctccaaact tctgtcgctt 2763901 tttcccattc ttttttataa actatatgtg aggcttaatg gcgaaaggaa ggaggaaggg 2763961 aaatggaggt ttacagtgac cgtcagttag caaaagatca agcagcccgt ctcagacaag 2764021 gtttttctgc atatgccgaa acaaactcac tcgcttccct catcaaaaaa gaacttcaat 2764081 cacacaatct ccaagtctac gaggacctta ctgatttcgg ctgctggttc atccccgtca 2764141 cagatgaaca ctaagagaga gggtctcccc tctactcgtg ttctttacat aatgtttcca 2764201 gatcagctaa aatacgatca gcttcatccc agctgtaaat agaggcgcct gaagctaacg 2764261 gatgccctcc gccgttatat ttccgggcaa gtccgttaat gacaggcccc ttcgaacgga 2764321 atctgactct gatttgatcg tcttcttcta cgaaaaacac ccaggcgcga atacctgaga 2764381 tattgccaag cgtcccgaca agctgcgacg cttcagaagc cgttgtgccg aatttttcaa 2764441 gcgtatcctt tttgatgaaa acagaagccg ccccgttttc ggacaaagac acattttgaa 2764501 agataaagcc gttaagcttc accacattca gttttgtttc atacaattga ttaaataact 2764561 ctgaggaaga gaatggatac tgaatgagct cgcctgcata ttttagtgtt ttttccgtgg 2764621 tattcggaaa taaaaagcgt ccggtatctc caacaatgcc ggcgtagatc agctctgccg 2764681 ctttcgtatt cagcttccag ccgtgctctt ttccttctaa atacagctcg taaatcattt 2764741 cacttactga gctggcgctt gtatcgaccc agagaaggtc accgtatgga tcttcgttcg 2764801 gatggtggtc gattttcatt agtttggcgc ctgaaggata acgctgatcg tcgattcttt 2764861 cctgatttgc cgtatcgcag acaatgacaa gtgcgccttc atatgtttca ttgtccacct 2764921 catcaaggga atataagaaa gagagggacg gttcaggcgt gccgaccgca aaaatatttt 2764981 tttcaggata tgtttcacgc aggatttccg taagcccaca ctgtgatccg taggcatccg 2765041 gatcaggacg cacatgtcta tgtaagataa tcgtgtcata taatgatatg gttctgatca 2765101 attctgtttt catttgatac tcctttattg tttttattca ttaaatcaca ttctctgccg 2765161 acggaaaaga aaaataacgt caaaaccaag cccgtttttg tataaaatgg ggttgtaaac 2765221 ttttacgatg gaggatttca tttatgctgg ttcttgtttt tttgattggg ctttcagcct 2765281 gcttttatgt gtactataaa gtaaaaggcg tacgggcaaa gccatctttg gcaaaagaaa 2765341 tatgttcagc aaaatcaagc atggccttag ggtcactagt cctgttctac gggcttaacc 2765401 aaatgatatt attccattca gtattaacgt tagtaatcgg cggtatcttt atcgtcatag 2765461 gagcaggaag cgcttgggca ggttataaag ccttcaggca ttacaatccc cttcacgcca 2765521 aagaagctga aagagatcac gcgtaagggg cgcctgaacg tcccttagct tctttccatc 2765581 agctgaacca tcagcatcgc tttagacacg atatgacctt ggctgtgcac ttccacttcc 2765641 attttcccaa actttctgcc ggcctccaag atgcgaggtt tgacttcgat gactgattcc 2765701 atctgcacag gcttcaaaaa gaagatggtg atgctctcta tgacgagttc gccgcgtttt 2765761 ttcgagcgca aaaatcggtt tgccgcttgc gtcaaaatgg tcgtaaatac gccataagaa 2765821 atggttccaa gctgatttgt catttgcggc gtgacttcat actcgtaaac cgtttgatct 2765881 tctttatcat caccctcatc tttaaacccc cttgaaacga tatcatcaag cttctccccg 2765941 acctgcggct gcttttgaat catttgaaga gctttcaata cgtcttggcg gctgatcatg 2766001 ccgatgagtt tttggtggcc gtcagtgacg ggaagcactt cgatcccttc ccataccatc 2766061 atttgcgcag ctgaagcgac agatgttttc ccaataaccg tgacgggatt tttggtcatg 2766121 actttttcta tagatgcatt tcggtcatgg ccagcaatat cttttgatgt cagaatgcca 2766181 tggattttca tttgatcgtc gacaaccggg aagcggccgt gccccgtttc aaaatttttc 2766241 tcataccatt tttcaagttt atccttaggc gaaagatata ccgtgcggtc agcaggtgtt 2766301 aggatgtcct ccaccaaaac aatttctttt ttgatcagct ggtcatatat tgcccggtta 2766361 atcatcgcgg caactgtaaa ggtgtcatag ctcgtggata aaatcggcag ttcaagctca 2766421 tctgccagct gcacaatgct gtcatccgtg ttaaagcccc cggtcaccaa tacggccgcg 2766481 cccgcttcaa gcgcctgcct gtgtgcattg attctgtttc cgacaatcaa aagattcccc 2766541 gctgcggtgt aacgcatcat cgcgtcaagc tccatcgcgc cgatgacgaa tttattcaat 2766601 gtcttatgga gccctgccct gcctccgagc acttgtccgt ctataacatt tacaacctct 2766661 gcataggtaa gcttttcaat gttctctttt ttcttttgtt caattctgat tgtgcccaca 2766721 cgttcaatcg tgctgacaaa ccctttattc tctgcttcct tgatcgctct gtacgcggtt 2766781 ccttcgctta ctttcatttc ctttgcaatt cttcggacag aaattttttc accgacaggc 2766841 agtgaatcga tatacgttaa aatttgttca tgcttcgttg ccaagccttt cacctctaag 2766901 gacagtcttc ttgtttttat tataaggttt caaaggattt atacgcaatg aggctggaaa 2766961 ataaaaaaga agcccgaccg gcttcttaca gcgttgattt cgttccagtc aaacgcaagg 2767021 accacgtgat tccttttaca tcgtaaagcg gaaaaacctt tatttttctt ttaaatggac 2767081 atcaaccgct gtcttaacaa tatttcgatt ccctatttta gataaaacaa ataaaactgc 2767141 ggatagccat atcgccccta tggccgtata gatcaatgga tgaacagctg tgtttgcgat 2767201 ccattcattt attaatgttc tggcatttac cagaataata aatcctccta caagcacacc 2767261 catcaattgc ggatgaaact tctgcaccag ccatgctgcg ataggggcag cgataattcc 2767321 gccggccatt agtgaaaaca cccataacca attgacgtcc tcccatccta atgaaataag 2767381 aaaaccggcg gttgcagata cggcgatggc aaattcactt gtgtctacag tcccgacaac 2767441 tttcctcggg ctcaagcctt tgcgggataa taaaatcgga gtggtcaccg gtccccagcc 2767501 gcctccgcct gtggcatctg caaaaccagc gatcactccc aatgggatgg attgttttcg 2767561 gtttaacggc acatgcttct tctcaagagc cggcttatat tgaaataaaa acctgatcaa 2767621 tacatatccg cccagaagga gcaaaaacaa agaaatatag ggtttcgcca catctccagg 2767681 taattggctg aggaatgccg cgcctaaaaa agcgcctata gagccgggaa tgacaagctg 2767741 ataaacggtt tgtttgtcaa cattgccaaa tttaatatgc gacactcccg atgcggcagt 2767801 cgttacgact tccgctaaat ggacagaagc cgaagccaca gcaggtgtga tgccaaacgc 2767861 caataacaaa gaagttgagg taaccccata agccatacct aacgaaccgt ctattaactg 2767921 cgacaataaa ccaataaatg caaaaacgat taatttcttc atcagaacac cccatctata 2767981 tcaatcagat atttttgact cttcattcga atctaacaat ctcttggcgc tttcatataa 2768041 aaaataagag gctttgataa ttgcagtttc atctattgta aatgcagggt ggtgccaatc 2768101 atgatcaccg tctgttccaa aaaacgcaaa ggatcccgga atatgctcaa gataataagc 2768161 aaaatcttcc cccgcggttg atggggcggg atcaatgact tgaagtttcg ctttatgtgc 2768221 agcgtctcgc accagccccg taattgcctc atcattacaa agcggcggcg gtccggaatg 2768281 ccacttcaca tttgccttta acgagaaagc ggcagaaatc tgctctgtga ctgcaaaaaa 2768341 acgctgtttc acttgattac gaacctctga atcaaatgta cgaacagtgc cctcaatgac 2768401 cactgtatcc ggaatgacat tccaagtgct gccgccgttg attttcccta cggttaaaat 2768461 cgcgctttgc agcgggttta catttctgct tacaatcgtt tgcagggcga caataagctg 2768521 agaggcgccg ataattggat caaaaccatt atgcggcaat gctgcatgag cacctttccc 2768581 ttctatctct actttaaatc ggtcaacagc agccataagc gggcctgttt ttaaccctac 2768641 agtcccaacc gcgatatccg gtttattgtg aaggccaata accgcatcaa tgccatccag 2768701 ttggccgtcc tctatcactt ttgtagcgcc tgcacccgct tcctctgctg gctgaaataa 2768761 taaacgaatc tttcctttca gactgtcttg attttccttc aataaaaagg ccgcaccaag 2768821 aagcgctgcc gtatgaaaat catgaccgca cgcatgcatg atccctttat gtttagacgc 2768881 ataaggcaat cctgtttttt cttcaattgg caaggcgtca atatcagccc tcaaagcaat 2768941 cgccggacct tctgactccc ctgctatgtc tgcgaacaca cccgttttta gagcagtagg 2769001 gcgaatctgt atcccctttt ctttaaggca tttttttata aaagcagttg tttcaaattc 2769061 ttcttttgac agttcaggat attggtgcag gtgccggcga atgccgatga gctgcttttc 2769121 tagcgttgag agatttacgg gattagactc ctctttcaac gtcaggatgt catttcctgt 2769181 agtctgatat ggataggagc cttctatatt tctccaataa tccaaagaca tatgttccgc 2769241 tcctttccct atcccaatat attttcttca gactcttcaa cataagatga aataaatcgg 2769301 ttcaatttat cagcaagacc gcccgcccca aatcttatat acttgctgga aactttcgga 2769361 ttatcttctt tcaaaaagct taaaaaagat aaaatataaa tgcgcctgta agctacttgt 2769421 gtaattccgt actcaaaaaa ccagttatca atgacattgt atacgcctcg gttgacgcca 2769481 tataggttat tacatttctt gtaaaagcag agatccggaa gatttaactc ctgatgggaa 2769541 agaaggcttt cttttttgtt tggtgccata atcccaatca gctcaaagcg ttttgcaacg 2769601 cacgaaatat cctttttaat ttgctttgtt aaagactcca aagaatcaaa ccttctttct 2769661 tctctaattt taaagagaat gctgcattcg attttttctc cataaatgtc tctatgaaag 2769721 tcaaacaaaa aaatctccaa tgtcttttca aggttagagc ccaccgtcgg tttcacaccg 2769781 atattcataa cccctaaatg aaattgatga ttgactgtcg ccagaacccc ataaactcca 2769841 ttacgcagcc catgtatttt tgcatctaca tttgccgtgg ggaatccaag ctttctgcct 2769901 aattgttttc ctttcacaac cgtaccggca atgatcgtca aaaaagtcag cctcctctct 2769961 cagcttccgc attcgatcag acgaaaccta atgatgtgat gaatgtaaaa cggattgatg 2770021 ctgcggaatg ccaagaccga gattttcccg caatgtcccg ccgcgataat cttgacgata 2770081 aagccctctt tcttgaagaa tcggaatcac cttttctaca aaagcatcaa gtgttcccgg 2770141 tatatccgac ccaacgataa acccatccgc cgcctcagcg ttgaaccaag tttcaattaa 2770201 ggatgcgaca cgctctggtg ttccgatgaa tagagtccgt ggaaaagcca tttcctgtgc 2770261 tacctcccgc aatgtcagat ttctggcttt tgcttctctc ttaatccggt ctgttgtgct 2770321 ttgaaacgca ttctttccca catcgccaat atcgggaaat ggctcatcca acgggtaaac 2770381 actcagatca taatcatcaa aaaaacgggc caaataagta acagcatttt caatcggtat 2770441 caattctgca aattcacgat acttcttttc cgcctcttct tccgtatctg ccacaatcgg 2770501 gctgatccct ggaaaaatcc gcacacttga aggatcacgc ccttcatcag cagctcggct 2770561 tttcacatcc gcataaaacg cttttgtctc ttctaatgaa ttggaatggg taaaaatcgc 2770621 atccgcattt ttagcagcaa actgccggcc tgtttctgat gaacccgctt gaaacactac 2770681 aggctctccc tgcttagagc gcccgatatt caagggcccc tctacttgaa aatactttcc 2770741 tttatgattc aggcgatgaa gcttcgcctg atcgaaaaac tgccctgttt tcttattgtg 2770801 tataaatgcg tcatgctccc aggaattcca cagcccgcgc acaacatcca aatgctcttg 2770861 tgcgatctcg taacgttcag tgtgttctgg caaattagac ttactatggt tgcgcgccgc 2770921 tccttcctgc ggcgaagtaa ccagattcca gccggccctg cccccgctga tatggtccag 2770981 cgacatcaat tgtctggaga tagtgaatgg ctcagtaaaa gatgtagaga acgtccctac 2771041 taaaccaata tttttggtaa ccgatgccag cgcagataaa atggtgatcg gttcaaaacg 2771101 gtttaaaaaa tgaggaatcg atttttcaga aataaataag ccgtctgcaa tgaaaataaa 2771161 actaaacaaa cctttttcag ctgtttgcgc ctttttcatg taaaattcaa tattcgtgct 2771221 ggccgaggga tcaacatcgg gatgacgcca gccgtcagtt gttcccccga caccgtgaat 2771281 catggctcca aactgaataa aatctgcacg tgtcatcttt ttgcctcctt tatctgtgca 2771341 tgattagcaa gtgcaagatc aaggtgttca atgccgattt cagttatccc ttgatactga 2771401 ttgccgcgcc cgatttcgac cacaggcaca tggcgcaccc catatttcac ctgtaaaata 2771461 tcccgaagct tttctttctc tgaaacatcg atattttgga acgggaaccc tttttcattc 2771521 aaataattct tgacttcctc acaatacgaa cagccttttt tactccaaac cacaatgttc 2771581 acaacatcac tcattcttct gtccctcctt aacgttttgc agctaaaact gcatcgctca 2771641 gcagctgata agacagctgt ttttctacag catttttgat cggtgtaaaa ataacaaaat 2771701 cattgatttt gtatgtgcct gataaacgtg ttaattcttc tgccacttct tcctttgttc 2771761 cggcaataat cccggttttt tgcacgatga tgtcataggg ctctgtgacg ttttccagat 2771821 aggcctcagc ctgttcgcgg gaaccgacgt tgaccttacg cccgtctttc aaaaccactt 2771881 ttatcgattc acgcgacaca atatgttttt ccgcttcttc ttttgtatgt gccgcaaaaa 2771941 cagcgggggc aagatgaaat tcagcctcag atcctggcgg gagatgcgcg tcaaatgctc 2772001 ggcgggcttc cttcagcact tcctcttcac cgttaataaa gtaagcaaag acaaaagaga 2772061 ttcccagttt tgcagcagaa atggcactct ctgtgcttcc tcccaataga aaaatacccg 2772121 gcttccgatc aacctgcggc ctaggacgca atgcggcata gcggtgggta tcaggaaaat 2772181 catcccgaac gaaatgagta agctcctcca gtttttcatc aaactgacgc accggttttt 2772241 tatattcggc ctgcagcgcg tctgtggaca gctgaaaccc gccgggcgct ttgcccactc 2772301 caagatctat acggccggga gctaacgctg atagaagatg gaattgctcc gctactttat 2772361 aagagctgta atgctgcagc atcactccgc ctgatgctaa acgaattttt cttgtgcttg 2772421 cagcaagata gcctaaaaga acctcgggtg cagaccctgc aatctcatca ttgttgtgat 2772481 gttcggccac ccaaaatcgg tgatatccac attcttcagc catttgtgcc aatttcactg 2772541 tatgctgtaa tgtatcagct gctgtctccc cttcaccaat caagctttgg tctaaaatac 2772601 ttaagcggat catatcaccg gctcctttat gtgttctttt ggttcaaata aatattccgg 2772661 cgaaacacgg cggagaaact gcctcgttct gtcttttttg gtatggcgga agacttcctc 2772721 cggggttcct tgttcaacaa tgactccttc atccataaaa acaacttgat cagagaccct 2772781 tcttgcaaac tccatttcat gtgtaacaac aatcatggtg gctccggttt tcacgatttc 2772841 cagcattacc tcaagcactt caccgaccag ctccgggtca agcgctgccg tcggctcatc 2772901 gaacagcagc acatcaggat gaatggcaag cgcccttgct atccctaccc tctgcttttg 2772961 tcctcccgat aactgactcg gataagcgtt caatttatct tgaagcccga cctttctcag 2773021 ttcattttcc gctacggcat acgcgtcttg ttttctcatt ttccgggcaa tcgtcaagcc 2773081 ctccatgaca ttttcaatca ccgttttgtg agcaaacagg tggtattgct gaaataccat 2773141 tgccgtctgt tttctgagcc agtgaacctc ttttttggac ggaaagcggc aattaatcac 2773201 tttgtcatgt atagaaatga tcccttcgtc tggacgttct aataaattca ggcaccgtaa 2773261 aaaggtggtt ttccctgatc cgctcggccc gataatcgtc acaacttctc ccttgcgtac 2773321 cgtgagattt atccctttta atacatggtg gatgccaaac tgtttatgga tatttttaat 2773381 ctcaatcata aagtgcctcc ttgaaatctg gctgcctttc tctctaatac tccatttgcg 2773441 gattctagga ttagagtcag cacccaatag ataatcgctg ctccgataaa cgcttctaaa 2773501 aatgcataat tatcagaagc aacgatagtc gccgtccctg taatctctgg gacagccact 2773561 atagccgcga tagaggtggt atgcaaaaag ccgataccca aatttgtgaa gtttgggatg 2773621 gaaaccttca gcgcctgcgg caatattaca cgccgaaagg tttggctgta tgtcaagccg 2773681 attgaataag ccgcttcgac ctgtccggta tccatcgcca gaatgcccga ccggatgatt 2773741 tctgtgagat aagctccggc agttaaagac aaggccatga tgacaaacat ggagaccggt 2773801 atctcattag cggaccagcc gagatgaaaa aaactgctga cttgatctgc aacaggcggt 2773861 atccctaaat aaatcaacat aatgtgaaga attgcaggtg tacttcgaaa gaaagacaca 2773921 taaaaccttg agcaagccac caagccctta attctaaaaa ttctaacaat tatatttcca 2773981 agagccacga gaaatccaaa cacaatcggc aaaacagcca tcatcaatgt cagaggaatg 2774041 gtctttacca tttctttcat ggcggaaacg ataaatggaa agtcaaattg caatcttctc 2774101 ccccctcatc cgaagaaata tatcaatgta tgttcatgtc aaaaacagta acaatccttg 2774161 tttgattctt cttgattcgt ttttctgcca ctcgaaagaa ccattcgaat aaaaccgcta 2774221 cagcataata aacaatcgat agcgcaatgt aaacttcaag agaatggttg cttgaggtaa 2774281 tcagtgtttg gccccttccg gacatatcca taacacctat tgaaaaggct agagacgtat 2774341 cttttaaaga actgatcacc atgtttccca tattcggaaa cgcctggaca agtgcctggg 2774401 gcagaacgat tcgcctgaag gcctgactac cgcttaagcc aatactgtac gccgcttccg 2774461 tttggccttt atctacactg cccacccccg ctcgaatgat ttctgcggct gccgctgcat 2774521 tgcttaacgc gtaggttgcg acagcagcat aaaacgggtc catttttgat gtatcaatcc 2774581 cgataagccc cgtaagcgcc gggatcccgt aaaacacgat gaaaagctgc accatgatag 2774641 gcgttcccct gaaaaacgag atatacactt ttgccaattg atttacaatt ggaatattat 2774701 agatgcgggg cagtgccaga aagagtccta atacaaaacc gaaaagcaag gacagtgtta 2774761 aaatgtataa tgtaaccggt aaataagcgg ttaacgtcgg cacaaaatct ccaatcatgt 2774821 tcatatcaaa cgctttttcc atcactgctc cctctctttt tacctaatac tgctctttgg 2774881 aatagtcgtc accaagccat ttcaaactga gccttttcaa cgttccgtca tcaatgattt 2774941 cctgtaaggc tttatcaata tcgtcactta acgtttgttc atttttgtta aacataaaat 2775001 acactttggc atttgaaagc acattaccga cggttttttc tttaatagtg ctcgtcttgt 2775061 tttgaaagtc tactgcaaaa ggcgttgaga tcgttgcgtc cgcacgcccc gatttcagct 2775121 gattcgcagt ctcatttgcg ccttggccct cataggcaat ctcaaacggc cgtccattat 2775181 cctcattcca ttttttcagt acaagcgctc cgttggaggt tgcactcgta atcacccgtt 2775241 ttccttttaa gtcttcaatt ccacggatcg tatcgttatt ttgaagcaca gtaattttta 2775301 aaggaaaatg gttgtaagca accttgttaa acagaaattt tttctcacgc tctttgcttt 2775361 tctccatttg atgtgccacg atatcgactt tatgctgtcc gaggctgaca agcaggttgg 2775421 aaaattccat cgttttaaat gtgaatttat aatgtggcag gcgcttatca agctctttga 2775481 tcagttcgac atcataaccg gttaaatcgc ctttttcatc gataaagcaa atattcggaa 2775541 attgggttcc agttccgacc gtgatcgtct gtaccttctt ttgcccggct cccgtcgttt 2775601 gactgcctgc accgcaagct gacagaactg ttataagcga aaataatatt gccatgaatg 2775661 ctgttttcgt tttcatctca tcgccccatt tatttttcaa aacttgattt tgaataatct 2775721 gccccgagcc attttcggct tagttttttt agcgttccgt ttttctccag ctttttaatc 2775781 gcttgatccg tgtcatccgc caaggtttgg ctgcctttat taaacataaa gtacacctcg 2775841 gtatctaata acacgtcacc gactgtcttt tggcggaagg cgtgcgtttt attctgaaaa 2775901 tcgacggcaa acggtgtagc tatcgttgca tctgcgcgcc cggtttcaat ttgattggcg 2775961 gtatcattgc ttccctgtcc cgcatatttc aaatgaattg ggctgccgtg cgttttgttg 2776021 tactttgtaa tataatctgc cgcatttgac gtggcgccaa ctatgactgt ttttccgtgt 2776081 aagtctttta atgtatgaat cttgtgatta tcctctttca ccgtgatgta catcggcgag 2776141 tagttatatg ggactttatg atacaaaaaa cgcttttctc gttctttatt tttggccata 2776201 ttgtgcgcaa tcacatcaat ttttttattt ccgagactcg tcagcaaatt tgagaaatcc 2776261 atcgttttaa attcaaatgt atattgaggc aactccttat cgatggcttt catcacttca 2776321 atgtcatacc cggtcaattc acctttttca tttaaaaacg caatattcgg aaaatctgtt 2776381 ccagtgccga ctatgaccgt ttgagcctga cgatctgttt tgttatttgt ttgcgaacat 2776441 cccccgccaa gtaatgcaaa cactgacagc agcaaaacca atcctttacg cttattcata 2776501 ggctgcctca catcatgccc agctgggcgc acctaaaagc gttgggttaa atcgttccgg 2776561 aatcagaacc ttgtgcatca tcacacctat gtccccgtct ttttcctgct caaaatacac 2776621 ttcataccct ctccttctgt acatgtcagc aagccaagga tgcttgcgcg ccgatgtgcc 2776681 gagtgtcagc gcaggagcct tcagcatatc tcgaagcact ttttcttcaa catacgtaag 2776741 cagcttactt ccggcgcctt gccctttata ttccggcagt gtcgcaaacc accacacaaa 2776801 tggatatttt gaaggaggcg tctcactctc ccacgggaac ctgattgtaa tcgttgaaat 2776861 cagcttccca tcccgctcca gcacaatcgc tgaatgatgt tcaatatttt ctgataccat 2776921 ttggatatca gctctcgtgg atggccaatc aatatccagc tgccgaatgg gctgaaatgc 2776981 gctgttaacc agtttcaaca gctccgatgc atcttcaaca gttgccagtc gaaaaatatc 2777041 atcactcatt tttgtcactc ctcttcacaa aatatataat tcctatttgt ttactaagct 2777101 tttattgttt atactataaa gcatactctg atctttgact aatcaaaaaa agtaaacctt 2777161 cacttcagta attttaatga tgaaaaacag gagggagcac attggagtta cgctcaatca 2777221 aaacgtttca tacgattgta aaatttggaa gcttctataa agctgcagaa atactcaact 2777281 actcgcagcc gacgatatcg atgcgtatga agcaattgga gcaggattta ggcgtactgc 2777341 tgtttgaaag aggaaaaagc ctgcagttga caaaagcagg gaagcttttt tatgaacgaa 2777401 caggagatct tttgatgcaa tacgaggcgc ttaaacacaa cctctccgac ttaaaggaag 2777461 aagaggcagg cattatcaac ataggggttt cagagccaac cgccagtctg atattccccg 2777521 agattttaaa ggatttctta atggattacc caaagataac ggttaatatc aaggttgatg 2777581 acgccaatac ctgcagtcaa aagctcttag acgggacgat tgattttgca gtctgcggcg 2777641 agccggagct gattcttgaa aattactacc atccattttt ttatgacaca ttaaatgtga 2777701 ttgtatctga tcaacatccg ctcgctgaga agaaggctgt ccatttgtct gatttagcag 2777761 aagagcgctt catatttacg cccgccaatt gccccattcg cttacaaatt gaacagcatt 2777821 tacatagaga actcgggaat cgctacaaaa aaatggagct cacaagcagc atgtcacatg 2777881 aatattacgt acgtgaaaac atcggaattt caatctttac cagcaccgca cattctaaac 2777941 cgttcaacgg cactaaagtc attccaattc tgaacctgga tatcaccccg cccatagggc 2778001 tgttgacaaa tcaaaaagaa gttcattttg accgcgccac gaaggacttg atcgcccgga 2778061 taaccaaacg ttttcagcag cgcagcaaag aattggaagg aacctctgat aagaccatta 2778121 caggataact gaaaaaataa aaaccacctc ctgattcatc aggagatggt ttcacggttt 2778181 aaagctcgat cgtctcaccg accgacatga ctttgccgac tccgcccggc aggctgtcag 2778241 cgaatgcttc tgggtcttgt tcgatgaccg ggaatgtatt gtaatgcacc ggcacgacct 2778301 gttttgcgcg cagccattca gcagcaagct tggcgtcttc aggccccatt gtaaagttat 2778361 cgccaatcgg aaggaaagca aggtcgatat gattcaattc gccaatgagt ttcatatcag 2778421 agaaaagtgc cgtatcgccc gcgtggaaaa tcgttttatc ttctacagtc agcaaaatac 2778481 cggcaggcat gcctgtgtaa gtgatcgttt tgttttcttc atctgtgatg gctgatccat 2778541 gaaaggcctg tgtgagcttc acttttccaa aatcgaactg gcgggagccg ccaatatgca 2778601 ttggatgaac attcaagcct ttccagccta agtacacagc gagctcgttc ggggctataa 2778661 ccagcgcgtt attttgcttg gcgatttgtt cagtatcacc gacatggtca ttgtggccgt 2778721 gcgttagtaa gatgacatcc gcttttacat cctccggctt tatatccgtt aatgaattcc 2778781 ctgttaaaaa cggatcaaaa ataatatgat ggtccttcgt ttccactgtg attacagaat 2778841 gtccgtgata tgtcactttc atttctttca cctcgtcaca tgattttgtt ttttttattt 2778901 tcccttttta aaaagctgaa aaacttatgt tgtttgattc ttgttaatga cattgaggcc 2778961 tccggtggct tcaatgacag tccctgtcac aaggtctgag ttctcctcac acaagaaagc 2779021 gataatcctg gcaatatcct cgcctgtacc ggatcttcct atcggcgttt tttctttgcc 2779081 gattcgcatt ctggcttcct ctatcgatgc ttctttcatg tcgccgacaa tgtctcctgg 2779141 gcaaaccatg ttggcggtta tgccgaattc ggcttcttca atggcaattg tcttcgtcaa 2779201 agaagccaag cccactttcg cagcgccaaa tgccgatcgg tgaagccagc cgggcgcgtg 2779261 agccgcacct tggaatccgt acgtaataat gcgtccaaat tgctgttttc tcataatagg 2779321 aataaccgct ttgaataaat gaaagacggc gcttaaattt ccttccagca tgccatacca 2779381 ttcatcatca gtataatcgg ctaacttttt acgttcaaat atgtatggtc cagcgttgtt 2779441 aatcaaaaag tcgatccttc cgaagcggtt taaggcagcc tctgcaatac gcagcagatc 2779501 ttcttttttg gtgacatcac cttttacaaa ttgcagccgg tcaagacaat cgggacaggc 2779561 ttccttcagg cggctgactg cctcctcatc ctgtctgtaa ttgactgtta ctgaataccc 2779621 ctttgcaagc aacgtttcag tcactttgcg gcctaaaccc ttcgaaccgg cagtaattaa 2779681 agcatgtcgc acatgaatac ctcccaaagc aacgtcgccg ctttcaataa agtgtttctt 2779741 cttctacttt actataaaag gcttgcaata tcacttttta cactttggca tacaaaaaaa 2779801 gctgcctgta cagacagctt attctgcagg agatgaagac tcctgatcag gcatatcgac 2779861 ataaccgctt tgatatgctt ctgaaatgag ccttgttgtc tcctggcttt cttgttcatc 2779921 ataaatatag cgttccggtt cttttttcat cattctgcct cccatcatta tagaggtagg 2779981 ttggctataa tgacgggatt ttatgaagga aattttaaca aactcctgct gccacgcaag 2780041 ctttcgcttt ttcaagcgcc tgttccacct gtttgaatcc ggtgcccccg gcgctcattc 2780101 ttttttcaac tgcgtagtaa gggtctaaca cagtgtaaat atcttcttca aatagtgtgc 2780161 tcgcctgctg aaactcgcca aacggcatat cgcttaaata gatccctctt tcgatgcatg 2780221 tgtacacaag tttcccgacc acttcatgcg cttctctgaa cggcattcct tttttagcta 2780281 aataatcggc cagttccgtc gcgtttgaaa agtcttgttt tgttgcttgc ttcatgacgt 2780341 ctttgtttac agtcattgtt tggatcatgc ctgtgaagat ttgcaggctg ccctccaccg 2780401 ttttcaccgt gtcaaacatg ccctctttgt cttcctgcag atctttgttg taagcgagcg 2780461 gaagtccttt catgatcgta aacagcccca tcatatcgcc gtatacgcgt cctgttttgc 2780521 cgcggatcag ctccgccata tcagggtttt tcttttgcgg catcatgctg cttcctgttg 2780581 cgtacgtatc gtcaagctcg atgaatttaa actcctgcga gcaccataaa atgatttctt 2780641 cagagaaacg ggataggtgc atcatcagca tactgctgtt gcttaaaaac tccaaaatga 2780701 agtctctgtc gctgacgccg tccaagctgt tttcataaat ggcatcaaag ccgagcagtt 2780761 ccgctgaata atcacggtca attgggaagg ttgttcccgc gagcgccccg cagccgagcg 2780821 gagatttgtt aatccgcttc attgaatcct gaaaacgctc cttgtcgcgc tcaagcatcc 2780881 agaaatacgc aagcagatgg tgagcgaatg aaatcggctg ggcgcgctgc aaatgtgtgt 2780941 agcccggcag aatcgtttca acgttcgctt ccgccttttc aatcagcgca ctttggaatg 2781001 cctcaatcag ctcgatgatg tggccgacat gattcttcaa gtataaatgc atgtcagtcg 2781061 ccacctggtc attccggctt ctgccggtat gcagcttgcc gccaagagga ccgatttcgt 2781121 caatgagcat tttctcaatg ttcaaatgaa tatcctcata atcgactgag aattccaatg 2781181 ctccctcctc tgctttttgc aaaagggtat tcaggccctc tcggattttc aactcttctt 2781241 ctgctgtcag aataccgcat tttttcagca tggcagcatg tgcgagagac cctgtaatgt 2781301 cttcagcaac taaattttgg tcaaatgata tggacgcgcc gaactcgtcg acccattttt 2781361 ccggtgtttt ttgaaatcgg cctccccaaa gcttcttcat gctttaatct gctccttctt 2781421 tttcacgatg ctgttcactt ttgtcggaag tccccaaagc tcgataaatc cgattgctgc 2781481 atggtgatca aatgcatcgt cttttgtata tgttgcaagt ttttcatcat atagagagta 2781541 ttccgattta cgtccttcta caattgcatg gcctttaaac agcttcacgc ggacaatgcc 2781601 tgtgacatgc ttttgcgttt cttttaagaa agcgtgcagc gcgtctttta acggtgagaa 2781661 ccataagccg ttgtaaatga tttctgacat tttttgctcg atgatcggtt taaagtgggc 2781721 tacctctttc accagtgtca aatcttctaa ttctttatgc gctttgatca gtgtcatcgc 2781781 accagggcat tcgtatactt cccgggattt aatgccgacg aggcggtttt ccacgtggtc 2781841 gatacgtccg acaccgtgcg cgcccgccat ttcattcagc ttcaagatca gctcagaaag 2781901 cgagtaggaa acaccgtcaa tggagacagg cacgccctgt tcaaatgcaa tttcaatcac 2781961 ttccggcgtg tccggcgttt tttccagcgg agctgttaaa tcgtatgcac cttctggcgg 2782021 cgccgcccat ggatcttcta aaatgccgca ctcattggcg cgtccccaga ggttttggtc 2782081 gatagaatac gggctgtcaa gattgatcgg aatcggaatg ccgcggctag ccgcatattc 2782141 aatttcttct tcacgtgacc actgccattc gcgaaccggc gcgatgactt ctaggtcagg 2782201 gtttaatgat ttaatggaga cttcgaaacg aacctggtca tttcctttcc ctgtgcatcc 2782261 gtgggcaatc gcctgtgcat cttctttttc cgcaatttca accagttttt tcgcgatcag 2782321 cggtcgagat aatgccgaaa caagcgggta ttttccttca tacattgtgt gggcctgcaa 2782381 agagataagc gcgtaatcct gtgcaaattc ttcttttgca tcgatcacgt aggagtttgt 2782441 cgcgccgact tcaagcgctt tctgctgaac aaatgccaaa tctttgccct caccgacatc 2782501 caggcagcag gcgattacat tatatccttg ctcctgaagc cattttattg cgacggaagt 2782561 atcaagacct cctgagtatg ctaatacgac ttttttctgt tctgacatga taaaaatccc 2782621 ctctcaaccg tgtttctatt ttgtataaaa ataaattata tttaataaaa atacattttg 2782681 tatgtataca ctttaacaag tacgtttcgt tttttcaagc cttttataaa aaaaacttca 2782741 cctaaatttc aggtgaagtt tcatagtatt tattcattta cttgtctttt ctgatttctc 2782801 tgaccacatg cgcaagttcg ggaataatca gcttattcat tgccagcttt actgcgccgc 2782861 ttgagcctgg cgttgagaaa acagcggtat gctgaatgac gccggcagtt gctctcgaca 2782921 tgattgcggc agagccgata tcctctgtat aactcagcat cctgaatatt tctccaaagc 2782981 cgggcagttc tttcgaaaac agcggcgtta tggcttcaat tgtgacatcc cgatctgcta 2783041 tgcctgtccc tccgtttaag agtaccgcgt ctgtctgttc atccatgcag cccgcaagca 2783101 ctgaccgttg caaagcatcc ttttcgtctt ttacaatttc atatgcggca atatgatgac 2783161 cggcttcttc taaaaatgag atcatcagct tgccgctttt atcggtttca tctgtcctcg 2783221 tgtcactgac agtaatcact ttgcaccgaa cgatatcggg agcttcttgt ttatgctctt 2783281 gaacgctcat tggcccacct cttttatgtt ttctgtctgt cactatcatg catcaacaaa 2783341 aaagcacatt caagagaatg tgctttcatg cgatttattt tgctaaacga acaacgtcgc 2783401 gcgcaatcat gacttcttca tcagtcggga tgatcatgac ttttactgga gaatgcggat 2783461 agctgatgaa agcttcctcg ccgcgcacgt tattaagcgc agggtcccag tatacgccca 2783521 tgaattctaa accgcgaaga acgcgttctc tgacttccac actgttttca ccgataccgg 2783581 cagtaaagat gatcgcatct acaccgctca ttcttgcagc gtaagaaccg atgtatttgt 2783641 ggattctgct tgcgaatact tcaagagccg tttccgcgcg ctcatttcct tctttcgtag 2783701 cttcaacgat gtcacgaaga tcgcttgaga aaccggaaat gccgagcagt ccgctttttt 2783761 tgtttaatgt attcagtact tcgtcagccg tttggcctgt tttctccatg atgtatggga 2783821 tcagggcagg gtcgatgttt ccagagcgtg tgcccattgc tacaccggca agcggcgtaa 2783881 agcccatgga tgtgtcaata gattttccgc cttcaacagc ggcaatactt gctccgtttc 2783941 caaggtggca ggaaatcagg cgcaagtctt ttaacggacg gccgagaagc tctgccgcac 2784001 gctcagttac atatttatgt gaagtgccgt ggaagccgta tttacggatg ccgaattttt 2784061 catagtattc atacggcaag ctgtaaaggt aagactgctc aggcattgtt tggtggaatg 2784121 ctgtatcaaa tacagctacc gcaggaacat ttggaagcac ttctttgaac gctttaattc 2784181 caacgatatt tgccggattg tgaagcggtg ccaattcaga aatatcttcg atttccttaa 2784241 tggtttcatc cgttaataaa acagaatcgc tgaatttttc tccgccgtga acgacacgat 2784301 ggccaattcc gtcaatttca ttcaagtctt taataatgcc gaattccgtt aacttattca 2784361 gcagcatttt aacagctacc gcatgatctg gaatatcagt tacttctgta tttttttcgc 2784421 cgttcacaga aattgtgaat acgctgtcgg cgataccgat tcgttcaact aaacccttcg 2784481 ttaaaacggt ttctgaaggc atttcgaaaa gctgaaattt caaagacgag cttcctgcgt 2784541 taattgcaat aattttggac atgattgacg ctcctttata ctctgtatca acaacttcgt 2784601 ttttcgtact tttttcccgg tgaatatcaa catcttctcc gaaaaatatc tgacttttcc 2784661 atttaaacat tgtcatgtcg gcttttcaag tcaacttgcg tattgataac gcttacaata 2784721 agaagtcgtt attttcagac acattcacta taggttttgt attgatgaac gcttacaatt 2784781 tgcggttttt ccctctgtat tttgtgtttc aaagctggat tcaattcgtc aagtccggtc 2784841 ttcaaaagca taaataaaag cagcttaggc atcgacctca tacggctgtc taagctgctt 2784901 ttaaaacact tacttttctt ttttaaacca ttcatcaaat tgagccatca tatcaagcat 2784961 cgccttttga ttggagaaag acggaagatt cgcaagcaga atttgccccg gcgctttcgt 2785021 attctctcct tgtttctgaa gcacaaggat gcttttggca tgagcttcgt ctttaaaaat 2785081 agattttggc agctgcaaca gtgcgttgat atgaacctta tctttgaaaa actgtttcag 2785141 cttgccgctt tgggagctct caaacaaatg attcggaatc ataaaaaata agtagccgcc 2785201 cggtttggta tgcttgacgc tctgttcaat aaacagatga tgagcgaagg aatggccttc 2785261 gtcagctttg agctcaaacg cttctgctcc ttcgtcattc ggataatagc cgactggcag 2785321 atcacaaatg accgtgtcaa ctggatcgat aaacaacggc tcaaggctgt cctggtggaa 2785381 aagctcaagc tcttttttca gaaggttcgc ttgggcatag gcgatcttca agagcacatc 2785441 atcaatttca atgccaaagc tgtttgccgt tttttcagac agctggttca gcacggtaaa 2785501 cagaaggttc ccagttccca gggctggatc aagaatggtc agttcctttt tgtccgccat 2785561 aaatttattc accaaatagc tgatgaaaag cccgatcgta tccggcgtca tttgtctgtt 2785621 tggatgcgag atatctttca ttcctttaag gacggcaagc tgaaaagcct tgcgtaccca 2785681 ctcatgctca tacgtgccga attccgcttt ttcaagcaga gcctgaagtt gtttggtttt 2785741 ctgatcagca ggcagtttca gctgatccgt tttttcaaga aaatacattt ctcctgcttc 2785801 ggccagcgcc tctatatatg aaatctgcaa ttcattcttt atcataatcg cggcttcgtt 2785861 taacagctca tacaccgcac ctacatggtc tttttgcata ttgtgttcct ccttgccatg 2785921 aaaaaagctc cggcggcagc ctggagcttt tttccctgct tactttacta atgccttagc 2785981 agcctcaatt ggcttttcat agttcgggtg gtttgttgct tcgcttacat attcagcgta 2786041 aacgactttt ccgttctcat caaggacaaa tacggaacgc gcaagcagac gaagttcttt 2786101 aatatacaca ccgaacgctt cgccaaatga catatctctg tggtcagaca gtgtttccac 2786161 tttgtcaatt ccgttagcgc cgcaccagcg cgcttgcgcg aatggaaggt ctgcactgat 2786221 tgtgtagacg ttgacatctc caagctttgc agcttcttcg ttaaaacggc gtgtttgtgc 2786281 atcacaaaca cctgtatcaa ttgaagggat aacagaaata atcgttacct ttcctttcat 2786341 gtcagctaac gatttttctt caaggctgtt agtcagcact gtgaaatcag gagcttgatc 2786401 tcctaccttc acttcttgtc cgacaagtgt aaccggaccg cctttgaatg taatttcagc 2786461 cattataatt cctccctttt gtatgtatgt ctctatcata gtaaagtttc ctgcaaactg 2786521 caaagtttat gccaaaaaaa agttaactgc ggccagcgca gttaaccttt ttttaataat 2786581 tcatattgtt catttggttt tgattttggc cttggctttg gtttttgtta tttttcttga 2786641 acatttgctg gatgcgctcg agtgtttgag gggctgcgtc taaaattttc tctattaaat 2786701 gggtattttc atctaaatga agcattctga tgcctgtcga tccgacaatt aaaaacgcga 2786761 tcggcgtaat ggacacaccg cccccgcttc cgcctccgaa aggaagtttc tgttctcttg 2786821 tctcatcgtc ttccgatttc ttttcggccg gctttccgcc aaactcgctt ccgcctgcgg 2786881 cgaatccgaa tccaacttta gaaacagtta aaatcacact tccatcaggc gtttccactg 2786941 gatctccgat gatggtgtta acatcaatca tttccttcaa gttttccatt gcggttttca 2787001 ttaaaccttg gatgggatgg tctgccatat acgcttcctc cttaaactga tgaatcattc 2787061 tttgaagtca ttctagccga cggattcttc tttaatacgg atagctcccg tccgtatttg 2787121 acgaatttga aagctgcaag catagcatgt ccaaagcgaa aaaagaatat acactgaaaa 2787181 tgggtcttgg aaacagggac ttgaaacgac gggatcacct catagacagg tttattcaca 2787241 aagtccaggt ggtcgtagag cattgctgcg ataccgccct tcacgcccca tacagcaccg 2787301 gttaacacac ctgtcactgc cgcgtcctga attccgatta ctgtaaccca ttctagtttt 2787361 gtgatatgta aatgcgcgag aaaagacgcg ctgattttcc gcagtctggt gacctgatgc 2787421 aaaagcattt cgattttatt aatgctttgc tgcacatcgt tttgtgtaat ttttttcttt 2787481 ccgctgcttt ttttcatttt ggattcagtt ttttgtttga tatccactgt tccgtcttct 2787541 ttgttcacct taatcgccgg gattgttttt ttgatcctta taaggccaaa cagcgccgta 2787601 atcttcaagg tcaatttgtc attatcatcg gcatgaagat actccagcgc gacatggatt 2787661 ttcattctga gaagcagtac gatccctatg agaataagaa tggctgtcag tacatacacc 2787721 atattcttca cttcctctag gagcattatc gccaattcct aaaaaaataa acccggacgg 2787781 aagtccgggt tatcggttat ttgcggtata atttttcatg caccacggtg gtatccgcga 2787841 tgtaatcatg aatcccttgt tttgtaggtg aaaaggcaac aacgatatat aaaatccaaa 2787901 tcttatcaat ataccgtcca accacttcac gaaaaatcac tgtactccat gtcagcttgc 2787961 tatcttgctt cacagaaacc actttgaggc cgaacaccat tttaccaagc gtctgcctga 2788021 agtattttgt catgagtgcg aaataggcaa gatacacaat aagcgttgtc acactgtagg 2788081 ccgagaaggt aaacatgccg gatgttttcg gcagatccaa tacggtaaag aggggagaaa 2788141 cgagcaaatg gtttaatccc catatcacga gccaatcaag caggaaagcc cagaaacgaa 2788201 cccaaaagcc agcataggca tgtgtcagca gctccgcttc ttgcgggcct ttgatgtcat 2788261 tgcgctctaa ctcttcatat gtcgcgtcca ttattgttcc ctcctacttc gcatagagat 2788321 acatcattct cggcgaaccg gattgcgata gaatttctct catattcaaa aaatcaattt 2788381 cacttttaaa cattttgttc gcgcccatgg aaaacagtga gcctaatccg aagctttcct 2788441 cataagaaat gacagaggcg tttttcaaat ccttgtgatc ctttttcatg gccgtaatgg 2788501 tatcgtcata aaaaccaagc tcatcaacga ggttcagttt tttcgcctgc cgtccgtcat 2788561 acacgcggcc gtccgcaatt ttctttacct ctgctttcgg catgccgcgc ccttttgaaa 2788621 tgacatcaac aaagccttca tacgaattat caaccatcga ttgcatgatg tttttttctt 2788681 ctttcgtcat ctcacgggaa ggagacataa tgtccttatg ggccccgctc ttaatcgttt 2788741 caaaagaaat gccaagcttg tcggcaagct ttgaataatt gacgctttcc ataatgacgc 2788801 cgagtgaccc ggtcagggtt tccggtgtcg caaaaatctt atcagccgct gttgagatgt 2788861 aatagcctcc tgatgctgcc atcgaaccca ttgacacgta aatcggtttt ttcgtttctt 2788921 tcttgatttc ttccagtttc ttatgtattt cagcactttc atacactccg ccacccggag 2788981 aattcacctt cagaacgata cctttgaccg tcttgtcatc ttttgcgcgc tcaaggtttt 2789041 ttaagaacgt tctgtggtta tatccgtctg caccaagcag actgcttgag tccccattat 2789101 cctgaatggt gccgctgacc tctaatacgg caattttact tgagggactg ccgttttcca 2789161 gcgtcttctc ctgcgattca tccgtcagtg atgtgagatc cgtttgagcg cctttgacgc 2789221 tttcaaagaa actcatagag atgctgacga taatagacac gccgaaaatc cccagagcaa 2789281 tcactaatgc aatccatctt tttgcattca ttttttctcc tcctttttcc taaactctct 2789341 cattatacga ttcaatatga aaaatgtttc acttcatgag aaagctccgg cttaacgggc 2789401 tgccggcaaa cgtggtacac ttatggccaa aggtatttta tcacaaatac tggatggcag 2789461 aaaaacttaa atatgacagc aaaggggaaa tgggatatga ccgatcaacg ccgtaatgtt 2789521 tatttttttc acaaacagga tcaggaaacg aacgaacaag cccgctcgtt aacacaatta 2789581 gcggaagagc atggatttac cgttgtgaac cagcactcag acgccaatat tatcgctagc 2789641 attggcgggg acggcacatt tttgcaggca gtcagaaaga cgaattttcg tgacgactgc 2789701 ttgtacgtcg gcattaccaa aaaggggaaa gctcatttat attgcgactt tcatagtgat 2789761 gagcgagaaa aaatggtcga tgcaatgacg tttgaacaaa ttgaagtgag aaaatacccg 2789821 ctgattgaag tgacagtgga tcaagccagt ccttttcact gcttaaacga ggtatccatc 2789881 cgctcaagca tcatcaaaac ctttgtgatg gacgtgctga ttgacgatct gcactttgaa 2789941 acgtttagag gtgacggaat gattatctca acgcctacag ggagcaccgc ctataacaag 2790001 tctgttgcag gagctgttgt tgatccattg cttccatgca tgcaggtatc agagcttgca 2790061 tcccttaaca ataataccta ccggacactc ggctcgccat ttgtcctcag ctctgaccga 2790121 aagctgaccc ttcgtgtggt gcaggacggc aacgaacacc caatcatcgg cttggacaat 2790181 gaagcactca gcacgagaaa tgtgaaaacg atcgaaatca aactgtctaa taagaaaatc 2790241 aaaacagtca aactaaagga caattcattt tgggaaaaag tgaagcgtac ttttttatag 2790301 aaaataaaag gacaggctgc tgcctgtcct tttatgattt ctcatataca atctggccgt 2790361 taatcacggt ttttttaatc tctaaaagat gaagctgtgc ggggtcaatg gcaaacggat 2790421 caccactgag aactgtaaaa tccgcgtcat agccttccgc aatttttccg cgtgacttct 2790481 ctttataaat gataccggcg ctaccttctg tataaagctt tatcgcttca tatacaggta 2790541 aacattcact ttcattatag cttggcccgt tttgctcatg actgcttttc cggaggaccg 2790601 cggactggat ccctagaagc gggtcaacag gctcaatcgg ggcgtctgaa ccgcccgcgc 2790661 ataaaatgcc tttagatatg agggttttcc aggcaaatgc agtcttcatc cggtcttttc 2790721 cgagacggtc aatgacccac ggaaagtcgc ttgcaacgaa gtgcggctga aggtcaagtg 2790781 cgatcggcat gcgtgctgct ctctcgatta attcgttatc aagcacttga gcatgaataa 2790841 gccgatcatg ccggccgttt ttgggcggat gcttttctat tgcgttcagc actttttcaa 2790901 aagcaagatc gccgattgca tgaacagcaa cctccatccc tttttctctc gctttgcgaa 2790961 tgagccggcc aagggtttcg tcatcgtgaa cctgaacacc atttgttgat ggatcatcct 2791021 gatatggttc tttcaataaa gccgttctcc cgccaagcgc cccgtccgca aagattttca 2791081 tagcaccgaa ctccacatac gggccggaca gcttctccag ctgctcccat cgatcgacag 2791141 cttcatgatg aacgagcaaa tggcagcgaa acggatactt tccgccagcg gcagctttct 2791201 cataagcttt catcggcacc gaaacatcac cataatagga caagtcttcc gaatgaccgc 2791261 ccgtcaggcc ttttgtccag caatccttta ttgcagccgt taatgcctca tcaacatagt 2791321 gctgggagac tggcgggaca gccttcagaa tcaaatcctg cgccttatca aacaggagtc 2791381 cggtcggctc gccatttgca tcttttacga tgactccgcc gtcaggatca ggagtatttc 2791441 ttgaaattcc cgctgcttga agagccgcag aattgacagc tattgcatgc cggcatatac 2791501 gcttgagcaa gacgggcctg tcaggaaaca ggcgatcaag atcatgctta gtcaagtagt 2791561 caggtgtctc aaactgattt tcattccagc cttctccaat gagccaatcg tttttaggaa 2791621 gctgccgctc tctttccttc gcagcctgta aaattgaatc tttcgacgtc agtgcggaca 2791681 gatcgagctg aagctgtttc tcaccgtggc cgatcaaatg tagatggctg tcaacaaaac 2791741 cggggaacat cactgctccg ttcaggctga tttcttctgt ttccggcgac ccgtactttt 2791801 ccttcaaacg ttcatagctg ccggtgcctt ttataacacc atcctcaaca taaactgcct 2791861 cagtccgatc gccttcttcg agcatcgtat aaatgaaacc gccgtgccat atcgccttca 2791921 ttcacgttca ctctctttct ttacgccttt ttattggctt tgagctgttc ttcacgtttt 2791981 cttaattcca ctcgtctgat ttttgcagaa gccgttttcg gcaggctttc cacaaattca 2792041 atttctctag gatatttgta tggagcggta atcgtcttca catggttttg cagcattttg 2792101 acaagctcat cactgcgttt ttcatgattt tgcaggacaa catatgcctt tacgatggag 2792161 cctctgattt catcagggct tgcgacaaca gcacattctt ttacttctgg gtgcttaaca 2792221 agcgcgtctt ccacctcgaa aggcccgatc gtatagccgg agctgataat aatatcgtca 2792281 tttcggcttt caaaccagaa gtaaccttcc tcatcttttc ttgctctgtc tcccgttagg 2792341 aaataatcgc cgcgaatttg tgttttcatt ctttccggat ctttaaaata ctctttaaag 2792401 agcgcaggcg tactgaggtg aacagcgata tcgccaacct caccaggttt gcagatttca 2792461 ccgtcttcat ttatgatctc cacctgattt cccggtgtcg gttttcccat gcttcccggt 2792521 ttaataggcg tatctttcaa aacaccaacc aaaagcgtgc tttctgtttg gccatatccg 2792581 tcccgtacct taatgccaaa gtgcttttgg aaaacatcaa tgacttcacg gttgagcggc 2792641 tcacctgcgg aaacagcgct gtgcagggca gaaagatcaa agcgtttcaa gccttcaacc 2792701 ttcgccatta agcggtattc tgtcggagtg cagcagaaaa cattgatttt gtagcgattt 2792761 aaaagctcta gatatttttc tgctttgaat ctgccgtggt acacaaaacc ggttgctccg 2792821 ctgccaagca ccgctaaaaa cggactccat acccactttt gccagccagg ggcagcagtt 2792881 gcccagacga tatccttttc agaaatgtca agccaagcgc cggcagaagt ttttaaatga 2792941 gcaaatgccc atccatgtgt atgtacaaca cctttcggct gacctgttgt cccggatgta 2793001 taagataaga aagccatatc atctcttgtt gtgtcagctg ttttaaattg gcttccgtcc 2793061 gcttcaattg ataagaggtt tttccagccg gcatcatttt caccaataga cagtgtaatc 2793121 agtttgtcag ccgtactgac atcccggaaa gcgccaataa attcggagta gacgatagcg 2793181 ccttttacct ctgcatgttc aatccggtat tcaagatctt tcgcgcgaag catttcggag 2793241 cacggaatga caaccattcc tgatttcagg atagccaaat aaacagcata ggcttcaagc 2793301 acccgcggaa ccattacaat cagcttgtct ccctttttaa atccaagatc agctaaggcc 2793361 gctccgattt tatttgtttc ttccatcagc ttttcatacg accaagattc ttgcttgccc 2793421 gactcgtcct cccaaagaag agcggttttt tgtccagcag cactgaactt ttccatttca 2793481 ttcactaaat tatattgcac aggggcaatt aaatcttcac gttttaacac gaacaactcc 2793541 tcactttctc cacccattat acataaatac aggctctttc cgtaaggata tgcctaaaag 2793601 caacctctgt aaacatagat tttataggcc gctggtcctt ttttatatgt aaaaaatgaa 2793661 aaagagtggg gataccccca ctcctaagcc attatgtgaa attgtaaatt agaattgtcc 2793721 tccgcccatg ttttgttgag caaaagatac aagacgtttt gtgatctctc ctccaacaga 2793781 accgttagcg cgagaagttg tgtctgctcc aaggtttaca ccgaattcag aagcgatttc 2793841 taatttcatt tggtcgatcg cttgagcagc tcctggtact aaaaggttgt tgctgttacc 2793901 tgagttattg ttagccatgt gtctcacctc cttgtgagta tagaatgtgt caaaacacat 2793961 ggcttcattc agaaaaactt tggtaattgt atacaggagc tgaaaattga tttaaaagag 2794021 ttcagcgaat ttatcgttag cttcttgttc gctataaagg gtcattgtct caatgttatc 2794081 taccgcttct tgaatatacg gctcgaaatc aacaaagctt tcaaagtgtt caattttctc 2794141 ttttttaggg cgtgttttcg ggcttggcgg tgtaaagatc gtgcagcagt cttcaaacgg 2794201 ctgaatactt gtctcatatg tgccaatttc ccgtgatttt tcgatgattt ctgttttgtc 2794261 catggcgatt agcggacgca aaatcggtgt tgacgtcacc gcattaattg catacatgct 2794321 ttcaagcgtt tggctcgcta cctgaccgag gctttctccc gtaataatgg caagcccgtt 2794381 tctcttttct ctgattctgt cggctatctg aagcatgagg cggcgggttg ccgtcattgt 2794441 gtaattttca ggaatttgtt tttggatgag ctcttgcgtt tttgtaaatg gaacaatatg 2794501 aagtgtcatg cttcccccaa aacgggacag acatttcgcc agatccatta ccttttgctt 2794561 tgcgcgctcg cttgtgtatg gcgggctgaa gaaatgaaca gcttctaccg acaatccccg 2794621 tttcatcgca taaaaaccgg ccacagggct gtcaaaaccg ccagaaagca tcagcatcgc 2794681 ttttcctgct gaaccaactg gcagcccgcc tgcacctttt tcatcacgaa ttgtcaaaaa 2794741 tgttgcttct tccctgattt cgattctgag cgggatgtct gggttgcgaa catcgaccgt 2794801 caatccttct gtatttcgca aaatatggcc gccgatttca gcgttcatct ggtttgtatc 2794861 taattcaaat tgcttatacg ctctctttgt cgcgacttta aacgtatcac ctggtttata 2794921 ctgatctttg atagccttta gtgcggttgc cttaatatca tcaaggcggc tgtcacactt 2794981 aattgccagg ctgaagcttt gaatcccaaa cacttgcttt aaatgaggaa aaagagcctc 2795041 aggatcctct ccatttaatg taatcgtcat acgatccctg ttggaaaagt attttaaatt 2795101 cggatagtct ttcaaaacga gtctgatgtt ttgttttaag cgctcaataa agctttttct 2795161 gtttttgcct ttggtcgaaa tttccccaaa acgaattaat atatgatcgt aattcatgtt 2795221 ctacctcatc atttccctta attttttgat gccaggacga agcgcgttca taaacggttc 2795281 tgccacatcg cttgtctggc tgtaatttaa actgattctg atgctgcttc cggcaatctg 2795341 ctctcctttg cccatctcta agagaacctt gctgggctta tgttcttttg ccgagcaagc 2795401 cgatgttgtg gagacgaata tatcctgttc ctcaagcatg tgtaaaagca cttccgcttt 2795461 aatccccggt acagagaaat taataatgtg cggcgcgcta ttcatttgag gcgtgttgat 2795521 aacgacgccc tcaatttcac tcagcctatt cataaacaat tcctttacgg cagtcatcgt 2795581 gtcaagccgt gtgtcaaaat cagcagaggc cagattaatg gccttggcaa gcgaaaccgc 2795641 accagcagta tgttctgttc cggcccgtat gcctttttgc tgagagcctc ccgttatgag 2795701 cggaataagg cgtgttcctt cttttacaat aagtgcgcct gtccccttta ggccgtgaaa 2795761 tttatgcccc gaaattgaac atagatcaat gccggccttt tcaattgcca agggcacttt 2795821 atagatgccc tgcacataat cgacgtgaaa caaaatgttc gaatgctctt tcagcacttc 2795881 tcctgccgct tcaatcggct gcacggaacc gacttcattg ttcacatgca tcatgctgac 2795941 aagcacggta tcgggacgga tggctgcttt tagatcttca atagaaacaa atccgtcttc 2796001 attcacagaa agataagtga tatcaaaccc gaacaactct ttcagctgtt ctaacgattc 2796061 cgtaacggat ggatgttcaa tagaagtggc aatgatatgt ttgcctgttt ttatctttga 2796121 caaagccgct ccttttaaag ccgcattatt ggcttctgtg gcgcctgacg taaatacaat 2796181 atcatatttt tttaggccta aggacctttt gatttgattt ttggctgctt gaagcagctg 2796241 ttccgtttcg gctccatatc ggtgcaaaga tgaaggattg ccaaagtatc ggctgctcgt 2796301 ctgttcatat acgttcaaga cttcatcgta aggcttcgtc gttgaactat tatctaaata 2796361 tatcatcttt tttactcctt tatgaaagcg gtacaaggta tgatatttat gttaccataa 2796421 caaaatttaa tagaaaatta cgaaaaacta gtattgactt ctaatttttt taccatataa 2796481 taagatttgt tcgtttcgtc atattatctg acaattaatt gacagaatat tttaacataa 2796541 ttattaggag gatttttttc atgaaacact cactgcctgt caaagatacc attattattg 2796601 gtttcatgct atttgcgtta ttctttggag caggaaatat gatttatccg ccggaacttg 2796661 gacaagcagc cggacacaac gtctggaagg ccatcggcgg atttttactg acaggggtag 2796721 gcctgccgct tctcggcatt atcgccatcg cattaaccgg taaggacgct aaaggccttg 2796781 ctgacaaagc gcaccctgtt ttcggcacaa tctttactgt cgtgctttat ttatcaatcg 2796841 gaccattatt cgccatcccg agaacaggaa ctgtttcata tgaaattggc gctgttccgt 2796901 ttttgactgg tgtaccagaa agactttctt tattaatatt tacacttatc tttttcggcg 2796961 ttacgtacta tttagcgtta aacccatcta aggttgtgga tcgagtcgga aaaattctga 2797021 ctcccatcaa attcacaatt attttaatca ttgttctcaa agccatcttc acgccgatgg 2797081 gcggattggg cgccgtgaca gaagcatata aaggaacacc ggtttttaaa ggatttttag 2797141 aaggctataa aacaatggac gcacttgctt caattgtatt tggcgttgtc gttgtaaatg 2797201 ctgtaaaaag caaaggcgtt acacagtcta aagctcttgc tgcagcctgc attaaagcag 2797261 gtgtgattgc cgctttaggc ctgactttca tttatgtatc ccttgcttat ttaggtgcaa 2797321 caagcacaaa tgccattggt cctgttggtg aaggagctaa aattttatct gcgtcttccc 2797381 attatttatt cggttcattg ggcaacatcg tactcggagc agcgattaca gtcgcatgtt 2797441 taacaacaag catcggcctt gtcacatctt gcggccaata tttttcaaaa cttattccgg 2797501 cattatcata taaaattgtc gttacgattg tcacgttatt cagcttgatc attgcgaatt 2797561 tcggactcgc gcaaattatc gcgttttctg ttcctatttt atcagctatc tatccgcttg 2797621 ccattgtcat tatcgttctt tccttcatcg ataagatctt taaagaaaga cgcgaagtgt 2797681 acatcgcatg cttgatcggt acaggacttt tcagtatttt agacggtatc aaagcagccg 2797741 gtttttcact tggatcttta gatgtgtttc taaatgcgaa tcttcctctt tacagcctcg 2797801 gcatcggctg ggtgcttcca ggaatcgtcg gagcggttat cggctatgtg ctgaccttat 2797861 tcatcggacc atccaaacag cttaatgaaa taagttaatg tcacagaacg cctgcgttat 2797921 tgcgcaggcg ttttgtaata aaaaaagagc ctgctcatta cactgcgggc tctttttcat 2797981 ggtcgtgatt atctaagcgg atatgtcagc tttgattttt tcaactgcac ctggcgcagc 2798041 cttttctaca gcggcagcgg caatttcata agagtcgtca taatcaaaag cataaaaacg 2798101 tctttccgct tctttcagct gttcagataa aatatgattc tggcttctga accggtttcc 2798161 gaactgaatg attttttcaa tgaggatgac ctgctcgaca agttcctctg attcccggct 2798221 tgccctgttg acgatatctt ctgcttgttt caaatgggct ccggcttctt ccatatttaa 2798281 tggaagttcg tttagttgat tgaccgtttc ttgaatatga tgatgcgcgt tctccagcat 2798341 ctcttgaata tggctcggaa tgcctggaat gttgctagtc ttcagcagtc ttgctgtctc 2798401 agaaattgtt tttttcaaat tgctgagcgt ctccctcgcc tgaagctctt cttttctcag 2798461 cgcttgcaga ttttcacgat actcggcatg ctcttttttc acttcttcaa tttgcttctc 2798521 tattgaagca acttcttcta ctaaaagtga gtaggcgaca tgctctgcat caagcttatc 2798581 tttaacggat gatagcagct ttccaatttc atcaaggcgc ttttcaaaag cctgctgttt 2798641 gccgagctca ccggctgtca gcctgtagct ttccttcacc agctcagttt ccgctttcgt 2798701 atgctctttc tcttctttaa gcttgtcgta agcaataatc aattcaggca ttttgcttag 2798761 tacggattga ccggcttcaa cttcgccctc cagctgctga taaacagatt gaatattttc 2798821 gtcaatgagc tgcaggattg cggacgcttc atcaatatcc agttcagtca tcaggacatg 2798881 ttccgctcgt ttcagctggt ttgacagatt ttctaattcc ttatcaagct ggatatgctc 2798941 aagcttgtac cctttttctt tcatttcgcc atagccatcc ttgagctttg caatctgtcc 2799001 gggcaccgtc tgtttacagt cagctaacag cttcggcaca tcatctatgt atgactgaag 2799061 ccgttcaaga ttgcggtcct gctcaagcag tacttttcgt gcagtaatat agtttccgcc 2799121 ttctgtttct tcttcaaatt gtttgatgcc gctccaaatt tcgtccagat ccttttcaag 2799181 gctgtcataa agctccccgt aaaggtggct gtaagccagc aggttttttc gagatttcga 2799241 atagcgctcc ctcacctgtt caatctcttc acggctcttt tcctcacttg tgacaagatc 2799301 gctgatttcc cgaagaatct tttcaatgct tgattcagcc gctgtcagca ggtcgtcgat 2799361 atgaacgagc acttgattgg cctttttaaa ccggtatttg tctgcatttt cctcggcatc 2799421 ataaaggagc tcttcaactt tcggcatgtg ggctgtgaca atctcatccc attcttcacg 2799481 ccacttctca aagaactctt ctgtctgacc cgtcattttt aaatgtttta ttttagacat 2799541 ttcttccacg atcgaccgat tcagaatttc aatcttccac gattccagcc ggtcgatttc 2799601 ggcgtagatt tttttcctga aaaagtagcc tgccgcaaac agcgcaagca gtacaattaa 2799661 taatccaatg acaaactcca taatgagccc ccttgctgtt taccttaatc tgtcagggtg 2799721 ttttatttat tcagaaagat ttcaggatat gtattgagaa aaactgtcgt tttcattgtt 2799781 attatgatac catgtaacaa acattttttg accagaaatc aaaaactttt tgtgcaaaat 2799841 cggcaggatt tgactatttt ttcatggggt gacatcaatg caaaagcgag acggacatat 2799901 tcacacacca ttttgccctc acggctccaa tgacacactc agacaatatg cagaagaagc 2799961 cttaaaaaaa gggttcgaat cgattacttt taccgaacac gccccattgc cgccatcttt 2800021 taccgatccc acgccgctga aagacagcgc gatggcgcaa gcttctttgg aacgctatat 2800081 tcatgaaatt tccggattaa aaaaagaata tcgcggacag cttagcatac ggacagggct 2800141 tgaagtcgat tatatcgctg aatttgaaga cgaaattaca ttattcctag acacatacgg 2800201 gccatattta gatgacagca tcttatccgt tcattttttg cgcacagact cttcctatct 2800261 atgccttgat tatgacgagc ataccttcaa agagctgatt tcagcctgcg gaagcattga 2800321 agcggtatat gaacaatatt accggagtat ctattcttcc attgtagcat ctctcggcgt 2800381 ttataagcca aaaagagtcg gtcacatcac actcgtccaa aaattcatca agctgtttcc 2800441 atacagcatg tcagagcata ttcgcggcct cgtttctctg tgcctgaatg ccattgaaga 2800501 aaacggaatg gagctcgact tcaatacttc cggcttaaga aaaacttacg ctggcggtat 2800561 ttatatcgag gattggatgc tgaatgaagc gaagcaaaag aagatcccgc ttgtgtttgg 2800621 gtctgatgcc catcaagcgg gagatgtcgg atatgcgtat gaggcgtttt tggaacggtg 2800681 ctagttggtg agcgccacgt ctcctgtccg gaagacgctt ctgatccaaa tcttgatttc 2800741 ttcaaaatac attttataaa aatacggctc gtgcggctgc atgtagagta cttctgaaat 2800801 atattgaggc tggagatagg gcatcatcaa gagagatttt aattggagaa taaaatgagg 2800861 cagcggcagc gttaaatatt cacgctgttt ttctccttcc tcaatgatca gctggaagat 2800921 atacttttcc ttcattagat atgtcgacat aatttccctg attaatgtgg agtcaattgt 2800981 gacttcccgg tagacaaaac gagttaattg acgatgatta tgctgatagg ataaaatatc 2801041 gaaaaccaat tgaagaagct gttcctgcgt gctttgagta gagatattgc ttgccgctgt 2801101 ttcaagcgtt ttgctgtagc cttcgtaaaa ctctgaaact aagtgttcca tcaagcctcc 2801161 tttgccttta aaatagtagg agatgtgcgc aacatttaca tcagctgact ttgcgatttc 2801221 acggacagac gtgccagaaa atcctttttg gttaaaaagc atgacagcag attcaataat 2801281 tttgtctttg gtgcttactt tcatacggct cactccttcc tcttgatact attcaagcag 2801341 aaagccgctg ttcctgtaag aacttatcga caaatgccgg cagaaaagcc ggaactttgt 2801401 tttatattat agaaaaagtg agggttttcc atgttccatg tcgaaaaaca atctggagat 2801461 aaagaaaaag actatcagct tctgctaaaa cagctcgaag ccatgaccga agacgaaaca 2801521 gaccaaatag ctaactatgc aaatgcctca gcactgctgt atcattcgct gcctgaagtc 2801581 aactgggcgg gtttctattt tgccaaagaa gaggatggac agcttgtgtt aggtccgttc 2801641 caaggcctgc cggcatgtgt tcggattcct ttcggcagag gggtttgcgg cacagcgtac 2801701 gcaaacggaa aagtggaacg tattgaggat gtaaacgcgt ttccgggaca tatcgcctgc 2801761 gatgcagcgt ctcaatcaga aattgtgctt ccgattcgtg tagacggaaa aattgtcggc 2801821 gtcttggaca tcgacagccc agtgaaaaac cgtttcgacg aaattgatga aaaatactta 2801881 actcaatttg ccgaaacgct agaaaaagcg ttagcgcagt aatataaaag cccaaaactg 2801941 atatcgtttt gggctttttt tattttattg agtcatgaat catcaagcgg tttttcccgc 2802001 tccgtttcgc gctgtagagc gcttcatctg cctcatgcac aagctctttc agcgactttt 2802061 ttgtttctgt cgtccagcag gagataccgc aggaaatggt tacctcgggt ttcgtatttt 2802121 ttctgaccgc gtaaaccagt cgctcggtaa tccgtttccc cactgcaacc ggcacatttg 2802181 gcaaataaat cgccagctcc tctcctcccc agcgggcacc gacatcatgc tttcggatgt 2802241 tgcttttaat cactgaagcg acttgaatta aaatctcgtc cccagtctga tggccgtacg 2802301 tatcatttac atttttaaaa ttatcaatat caacaagaat aaaaacaccc ttttgatgga 2802361 ttttcatgct gtattgaatt ttttcatcta aatacgctcg tgaatacagt tcagtcagct 2802421 gatctgtttt cacgagatgc tcaaggcggt cgcgaagcat tgaattggtt acagccagtg 2802481 tcgcgtgatg aatcagcgcc tgaaacagct tgtacatttc aaatgtaaaa gcgtacagct 2802541 cctgtttcaa taaaaccgca aagcctaaaa gccggtcgtt ttgaatcatc ggagcagcca 2802601 tcagcgagcc gtaccccgcc ttcccaaaaa cagactggcc attcccgatg aaaacccctt 2802661 tttcaccttc atacagcttt tctttcagct cattataaaa atctgacggc ttcgcttctt 2802721 taaaaaatgc tgtgctgcct gggagcaatg ttaggttttc aaaatggtct atatgaaaaa 2802781 atcccacttc ttctgcctga aacgattctg ccattctcac agccagatca ttcattgtat 2802841 cagtcaatgt cagccgctga ttcaggcgtc gtgatgtttc attaatcaat tccaaatttg 2802901 cgatgcttgc tttggattgt tcgtagagct gggcattttc aaacgctttt cccgcggcgt 2802961 ttgctaacag cgacatttca tcaaggcagg catcagtaag aaagctgtca cccgttcctt 2803021 cagccttcaa caccccgtat gtgccctgct gtcctttgat cggaatatag gcgacagatt 2803081 catttttccg caaaatgtct ccggacaaat acactttgag cgcaaaggaa tcggattttt 2803141 ccccttccat atacagctct tttgcaggaa tccctaaaca ttggtcttga tcgtgcgata 2803201 taaataaaga aaactcaaaa agagaaaatg tgcttgtcaa gctttctaaa agctgcttca 2803261 gcacatctgt ctgatcaagc agtgaatgga acagctctgt cattttgtat atcttttttt 2803321 ggtagatcgt tttgttatag agtctttcct gtttcatcga ctggtttaaa aatgaagcaa 2803381 ccacgtccgg aagcccttca ggaatctctt catcctgcct gcacgcaaga tggaaacgcc 2803441 tgccggagcc gtcctcaatc agataacatg aagcgtttat ttttgaagcg gaaaaacgcg 2803501 cttcaccatc tgccagtttt gtcacaaagt ctgatggtga cggtgtaagc gaaacacaaa 2803561 gggttgaaaa ataggtttga atagccgaag tcagccatat gaaagagtcg gtgaatgtga 2803621 ctttttcaga tttggttaat aaaaaatcga gcatatgata atgaaaggcg gataattgat 2803681 ctttagtttg ttctaccatg tttttatcac ctaaaagttt accactaatt tttgtttatt 2803741 atatcataaa cggtgaagca ataatggagg aatggttgac ttcaaaacaa ataaattata 2803801 taatgacctt tgtgtgaaat attgcagcct ttttgttcag cttctatgtt ttcattttgt 2803861 tccttatcaa taaggtgtat cgtgtaactc tctgctgctg gagcgaggat acatgaaaac 2803921 aaaatgtgca tggtcgaata gagcagacgg tttttatttt ccacaaaaat aaaaccaaag 2803981 gaggagtcac attatggctc gctatacagg tccatcttgg aaactgtccc gccgtctagg 2804041 aatctctctt agcggtacag gaaaagaatt agaaaaacgc ccttacgctc caggtccaca 2804101 cggcccagga caacgtaaaa aattatcaga atacggtttg caattgcaag aaaagcaaaa 2804161 gcttcgtcac atgtacggtg taaacgaacg tcaattccgc actttgtttg acaaagctgg 2804221 caaactagct ggtaaacacg gtgaaaactt catgattctt ttagattctc gtcttgataa 2804281 cgttgtgtac aagctaggtt tagcacgtac tcgccgtcaa gctcgccaat tggttaacca 2804341 cggtcacatt cttgtagacg gaagccgcgt tgacatcccg tcttacctag tgaaacctgg 2804401 tcaaacaatc ggtgttcgcg aaaaatcaag aaacctttct atcatcaaag aatctgttga 2804461 agtgaacaac ttcgttcctg aataccttac tttcgacgct gaaaagcttg aaggtacttt 2804521 cactcgtctt cctgagcgtt ctgaacttgc tccggaaatt aacgaagcgc ttatcgttga 2804581 gttctactct cgttaatcgt tttaaaaacc cctgccgcta tgcggtcggg gtttttttat 2804641 cggctttcgc ctcttgctgg ccaacactat cttgcgcctg ctgctcccaa tgatcccgct 2804701 gcagccgttc ttttgcaatc gtacacatga gattcacgct ttagcgctcc tttcatttaa 2804761 aaggtggtga ttggtcgtgt ttgccctatc taatatactc ttttcctttc attcctatgc 2804821 ggtaaacaaa aagatccttt gccttcagtg gcaaaggatc tttttcttat ttatacgtca 2804881 caaggaagta ttttttcttc ccgcggcgca gaacagtaaa ttggttttcg atgcggtctt 2804941 cacctgatag ggtataattt atttccgtct ggcgttcacc gttaatgtaa acagctccgt 2805001 tttggatgtc ttcacgcgct tggcgtttag aaggagataa tttagattgc accaacacat 2805061 ctacaagtga aagctcttgg gtgctgtcaa cttccataga aggaacatct ttaaagccta 2805121 cttttacgtc ttgagcagaa agctctttaa tattgccgct gaacagcgct tgggagatgt 2805181 tgatggcttg ctccagcgcc tcgcgtccgt gaacaagtga tgtcacttct tctgccaggc 2805241 gtttttgcgc ttcacgtttt tctggcgccg tttctgtttt ttcagcgtat gcttcaattt 2805301 cctcttttga aaggaacgtg aagtatttca agtatttgac aacgtcacgg tcgtctgtgt 2805361 tgatccagaa ttgatagaat tcatatggcg atgttttttc tttatcaagc cagatcgcgc 2805421 cgccttccgt ttttccgaac ttcgtgccgt ctgcttttgt gacaagcgga atcgttaggc 2805481 caaacgcttt tgctccttct tcttctgatt ttctgatcag ttcaagaccc gctgtgatgt 2805541 tgccccactg atcgcttccg ccgatttgca gtttacagtt tttgtctctg taaagattta 2805601 agaaatcata agattgaaga atcatgtagc tgaattccgt gtacgagatg ccggattcaa 2805661 ttcttgagct gaccgtatct tttgccagca tgtaattgat gccgaaattt ttaccaacgt 2805721 cacgaaggaa atcgatcaca ttcattttgc cgatccagtc aaagttgttc gcgatgacag 2805781 ctgggttttc tgctgcttca aaatctagaa atctggacag ctggtttttg attttttggg 2805841 accattcgga tacgatgtca gcagtgttta atgtacgctc tgcttttttt ccgcttggat 2805901 caccgatgag gcccgtcgcg ccgcccacaa gcgcaatcgg atgatgccct gcaagctgaa 2805961 aacggcgaag tgttaaaata ggcagcaggt gtccgatatg caagctgtct gctgtagggt 2806021 caaagcctga gtacaagcgg attttttctt cattcagctg tttatttaac ccttcttcat 2806081 ctgtcatttg ctgaatcaat ccgcggaagg ataagtcttc aagtaagtta gtcataagat 2806141 aaagctcctt ttttaattaa aataaaaaac gccccttcgt ttacacgaag ggacgattga 2806201 ttatcgcggt accaccctac taataagaga atgcaaacat tcgtcttatc actttgcctg 2806261 ataacggatc aggtccgttc tttcactact gaaagcctgg ccggctttgt ttgcaaaagc 2806321 ggttcatgag tgtattcgat atatccgtct gtgctgattt tcaccggcca tcagctctct 2806381 ggaacgtaag gatattctac ttgtctcaat ctttaccttt tcatatgaag ctatatcatt 2806441 tttaacataa ataaaatcct gtgtcaacgc cgccttttaa tcctccattg ttgacagatc 2806501 tccagccggc agattaagct cccatgcctt cagcacgcgc ctcatgatct ttccgcttct 2806561 ggttttcgga agcttatctt taaattcgat ctcacgcgga gccgcatggg ctgcaagacc 2806621 ctgctttaca aataggcgga tctcttcttt cagtttatca gacggctcaa atccttccct 2806681 gagtgcaata aaggctttaa tgatttctcc acgcaccggg tcaggctttc cgataacgcc 2806741 tgcttctgca atagccggat gttcgacaag cttgctttcc acttcaaatg ggccgacgcg 2806801 ctcaccggag gtcatgatga cgtcatcaac tctgccttgg aaccaaaagt atccctcttc 2806861 atccatgtaa gcagaatccc cagacacata ccagccgccc ggcatgaaat acgattcata 2806921 cttttcaggg ttattccaaa tggtatgcat catggaaggc cagccctttt tgatggcgag 2806981 attgcccatt cggtacggcg gtagctcgtt gccttgattg tcaacgatcg ctgcctccac 2807041 tcctggaatc ggcttaccca ttgaacccgg tttaatatcc atgcaaggat agttgcagat 2807101 gagctgactg cccgtttcgg tcatccacca ggtatcatgg attcgtttgt taaaaacttt 2807161 atgtccccat ctgatgactt ccggatttag cggctcaccg acactgagca catgccggag 2807221 tgaagttaga tcatatttcg cagccatttc atctcccgct cccatcagca tccgaaaagc 2807281 tgtcggcgcg ctgtaccaga cattgacgcc aagctgttca atcgttccat accagctttc 2807341 cgggctgaaa cgtccgccga cgatgacatt tgtcgctccg ttcagccacg gtgcaaaaat 2807401 gccgtatacc gtacctgtca cccagcctgg atcagccgtg caccaataaa tgtcttcttc 2807461 ctttaaatca aggacccact ttcctgtttg atattgctga atcatcgctt catggacatg 2807521 caacacgccc tttggcgtac cagtggaacc tgatgtatag tgaagcagaa agccgtcttt 2807581 tttatccatc cattcgatat ccaatcttgt gctttcctgt ttcgctgctt catcataatt 2807641 gatgatattc gtgccgctct cagcctctcc cccgactacg aagacatgct gcaagtgagg 2807701 cagtttgtct accggtattc tctccagcag ctcaggcgtt gtgacaacaa cctttgcctc 2807761 actgttttca agccggtctt tcaccgctcc ctccataaat gcttcgaaca gcggcccggc 2807821 gatggcgcca attttgattg cgccaagcat aataaaataa agctcgggtg atctcggcat 2807881 aaaaataaaa acgcggtccc ctttttccac atttccatac cgtctcagca cattcccggc 2807941 tctgtttgat tcttccttca tttctttaaa tgtgtatttt tcatcccttt ttgcgtcttt 2808001 ataataaagc gctactttgt tttttcgaaa cgattcggca tggcggtcaa tcgcttcata 2808061 cgccgcattc agtttccctg tctcatgcca agagaaatgt ttctctgcct cggcccaatc 2808121 aaaatgccgg tacgtttctt catagttttt taagttatga tccccctcta ttgctggtaa 2808181 cgctttcaag ttcatgccca aacatccccc tttgctgaag ttgtcacaat tattatagta 2808241 tatattcata ttcttctcaa tttttaaaat ataaaccatg ttgaaaacgc tttataattt 2808301 ggtattctta aagaaggcat gtatttttga taagaattga tgggacggtg aattagtgga 2808361 acatcataaa acataccatt cagcaaacat caaaacagca accggctctt tactgataga 2808421 agggcctgtc tctccagagg atttggcagg ttatgagttt cataaagatt taaccgcatt 2808481 tcgcccgcct cgcgagcagc atgaagcgct agtcgacatt gcaggccttc ccgaagggcg 2808541 cattattatt gccagagacg gccgaaccat tgtcggctat gtcacgtatt tatatcctga 2808601 cccgctcgaa agatggtctg aaggaaatat ggaggatttg attgagctcg gagccatcga 2808661 agtagcgccg gactatcggg gatgcgctgt cggaaagacg ctcctgaccg tcagcatgat 2808721 ggatgaacaa atggaaaact acattgtgat gacgacagaa tattactggc attgggattt 2808781 aaaagggatg aaaaaagatg tgtgggaata cagaaagatc atggaaaaga tgatgaatgc 2808841 aggcggattg gtctggtttg caacggatga gccggagatc agctcccacc ctgcaaactg 2808901 tctgatggcc cgcattggaa aaaacgtcag ccaagaatca attgagcaat ttgacaggct 2808961 ccgtttttat catcgttata tgtattaact gacactgaca aaggggaaaa aataatgatt 2809021 gttgagcaaa tcatgaaaag agatgtcatt acattaacga agacggatac gcttgaaaca 2809081 gcaatatgca aactgaagga attccatatc aggcatctgc ctgttgtaga tgaagaacga 2809141 cacgtgatcg gcatgattac agacagggac atgaaacagg ccagcccgag tatttttgaa 2809201 gaaaacaaac gaagcctatt tctcacacga agcgtagatt caattatgaa aaaggatgtt 2809261 gtctgcgccc acccgttaga ttttgtcgaa gaaatatcag ccgtgttcta cgagcatggc 2809321 atcggctgcc taccagtggt acaccatcaa aaattaatag gcattttaac aaaaaccgat 2809381 ttgctgcgga cgtttgtcaa attgacaggc gctgaccagc cgggctcgca aattgagata 2809441 aaagtaaacg acatcaccaa aagcctcgct gagatcagca gtctttgcca agaccttcaa 2809501 gtgaaaatat taagcgtgct tgtttatccg catgacgatc ccggtgtaaa agtgcttgtc 2809561 ttccgtgtaa aaacgatgaa tccgctgccg tttttgcagg cattacaaag aaatggacac 2809621 cacgtcgtat ggccgtcaga gcaaagggat ctgctatgag agacagtgta tttatctatt 2809681 ctccatccta ccaaacctat atgtttcatc aggagcatcc ctttaatcag cagcgggttc 2809741 tgttaacata tgatttgctt aagacgatca atgcctttga tgatggagac attgtcaccc 2809801 ccagactcgc ttcagaagag gagctttccc ttgtccacac ggacgattac attcaggccg 2809861 taaagcttgc gggcgccgga aagctccccg ctgaagaagg agaaagctac gggctcggca 2809921 ctgaagacac acccgtcttt gccggcatgc acgaagcggc atcactcttg gtcggcggca 2809981 ctttaacggc cgcagactgg gtcatgtcag gacaagccct gcatgcggca aaccttggcg 2810041 gagggcttca tcacggcttt cgcgggagag catcaggatt ctgcatatac aacgacagcg 2810101 ctgtggctat tcaatatatc cagaaaaaat atagcgccag agtgctttat attgatacgg 2810161 acgcccacca cggggacggt gtgcaattta cattttacga taatcctgac gtatgcacgc 2810221 tgtccattca tgaaacagga aggtatttat tccctggaac cggtcagatc caagaaaaag 2810281 gaagcggaaa aggatatggc tattccttta atattccgct tgacgctttt acagaggatg 2810341 attcttttct tgaggcttac cggacagcag cttcagaagt cgccgcgtat ttcgagcccg 2810401 atgtcattat cagccaaaac ggcgccgatg cccattacta cgacccgctg acgcatttat 2810461 cagcaacaat caatatatac gaagaaatcc cccgtcttgc acacactttg gctcatcaat 2810521 attgcggagg gaaatggatt gcagtcggag gcggcggata tgatatttgg cgtgtcgtgc 2810581 cccgcgcctg ggccagaata tggcttgaaa tgaagggaat tgacccgggt cacgagatcc 2810641 cgccggaatg gattgttaaa tggcaaaaac aatgccccgt ggcccttccg tcgagctgga 2810701 gcgatccggc tgatttatat cctccgattc cccgcaagcc tgaaattaca gaaaaaaatg 2810761 cccaaactgt cagcaaagca ttatatgcga tacgttctga acagcaaaga acaaagtaaa 2810821 aaacgacctt tacgaagagg tcgtttttga ttttttaatc actatttcca cacgccgatt 2810881 ttccttcatg tgttcatttg tcttgttatc ctttactggc tttgtatccg cataaccgac 2810941 agcaataaag cgcttggagg gaagcttctc tttagacgtg aagtattgaa tcactccact 2811001 tgcccgtgct gctgatagct cccagttcga cgggtatcgg tatgtcgaaa tgtttcggct 2811061 gtctgtatgt ccctcaacct gaatgtcatt tggaattgtt tgaagaagaa cggcaatttg 2811121 gtgaagaagt gtttcggcat ttttcagcac ctttgcctca cctgtatcaa acagcacagc 2811181 ctcctgaaga acgagcacga caccgcgttc atcccgtttg gctgtcattt gggccttcaa 2811241 atgattgtct tttatatatg tatttacttt cttgagaagc tgatcctgct gatcctcttg 2811301 cttcttcgta tcagatgggg atgtattctt tttttctatg gatgtttggt ccggctgaag 2811361 cccgttgcct tccttctgga tcgagtccac tgccgctttg aatttttgca gatcgatttg 2811421 ggacatcgaa aagagtaaaa taaagaacac aaggatcaag gtgatcagat ctgtaaaggt 2811481 taccatccag ctggatgaag attgactgtt ttttccgctt ccattccttc tttcaaaacg 2811541 ttctcttcta agcttcatgt acagatccct tttttgtttt tacttgtttt ggctgcttct 2811601 gccattcttc ccgtgagctg aaaacgacca gctggctttc aaggttgcgc gggttttttc 2811661 cggattgaac accgataatc ccttccacca ttacctgctt gatgaaaatt tcactttctg 2811721 ttttctcttc aagcttagcc gcgatcgggt tgaagaccat atttgccagt aatgaaccat 2811781 ataaagtcgt cagaagcgca atggccatgt ttggtccgag catatgcggg tcgtttaagt 2811841 ttttgagcat cagcacaagc ccgacgagtg ttccgatcat tccccatgcc ggagcgaatt 2811901 ctcccgcttt ttcaaaaact cgccgccctt ttcggtgccg ttcctccatt gctgcgattt 2811961 ctgaatccat gacgagccga atcgtttctt catcccagcc gtcaatcgct aaaagcagcc 2812021 cttttttcaa gaatggatct ttgatttccc gagcctgatc atccaatgat aaaagcccgt 2812081 gttttcgcgc gtgatcggaa agggaaacaa aggttttcac aagatctttc acattgtctt 2812141 cctggcggat gaatgcctgc tttaacacag agggcgcttt tttcagctca cttggcggaa 2812201 aactgataaa aacagcggcg caaagtcccc ctgttacgat gaagaaagag gtcagatcaa 2812261 gaaaagagcg gaaaccgctt actcccgatc ctgaaataat cccgataaca ataataatcg 2812321 ttcctaacac aaatccaaca ggtgtaagat aatcaaaacg tttcatcatt tctccccatg 2812381 aaaaaagcaa gaattcacca taaaggtgaa gcttgctctt tgtttttctt atgacttggt 2812441 tgactttcta agctctatac ggtgcggcag ttcgacgata tgctcttcaa ccggctcttt 2812501 attcatgagc ttcgtcagca gtctcatcgc aacggcgccg atatcatatg tcggctgaac 2812561 aactgttgaa agctgaggac gaaccatgag gcttaatctt gtattatcaa aaccgataat 2812621 gtcgagatcc tccggaatgg ataagccctg atcctgagcg gcatggataa tgccgagtgc 2812681 catttcatca gttgcagaaa gaatggctgt cggtttttta tccaggctca tcagatgctg 2812741 cagtgcttcg agtccggaat catatgtgta atccccttca gctacaaatt gttcattaaa 2812801 cggaaggttc gcttcttcaa gcgcacgttt gtagccttgg agttttttcg aacggttgat 2812861 cggttctgcc attggtccgg aaacgaacgc gatgtctgta tgtcctttat caaccaaaag 2812921 cttcacggca tcataaatcg cctgttcgta atcgatagcg actgacggtg tttcctcctg 2812981 ctcttctaca gaagcggcaa gtacaatcgg cactggagaa cgcttaaatt ccgccacatg 2813041 ctcgtccgta atgtttccgc ccataaacac gatgccgtcc acttgtttgc cgagcattgt 2813101 gtttaacaag tgcagctctt tctccatgtt ttggtcagag ttgctcaaaa taatattgta 2813161 tttatacatt gtcgcgatat cttcaattcc gcgcgcaagc tctgaataga aaatgcttga 2813221 gatatcggga atgatgacac ctacagttgt tgttttttta cttgccagcc ctcttgccac 2813281 cgcgtttgga cggtaaccga gacgttcaat ggcttccaag acttttttcc tcgttgtcgg 2813341 ttttacattc gggttgccgt tcacgacacg ggaaacggtt gccatgctta cattagcttc 2813401 tctcgctaca tcgtagatcg taatattgct catcctaaaa ccactccttt tactggatac 2813461 acttatcctt atctatagca taaacacttt atgtagagaa atgtcataat gtccgaattt 2813521 atgtcgttta tgatttgtaa gcgtaagtca gtagtgtaca ttatttttca ttattcatca 2813581 aatttaatta cttctcatga aattatacac gtttttatag atgatgaaaa cgtatacttg 2813641 gtttttataa ctaaataaac gagaaagcat aaaaaaaggc cgcaggcgcg gccttttgga 2813701 ttgttcaatt aagcgttgac tttcaccatt ggcttcagtt cattcagcca tttttcgaat 2813761 tcaggaatcg ccatttgctg agcagagtca gaaagtgcga ctgacggatc agggtgaacc 2813821 tcagccatta cgccatcagc accgatcgct aaagcggctt tagctgtcgg aagcaagagg 2813881 tcacggcggc ctgttgaatg cgtaacatca acaaagactg gcaaatgcgt ttcttgtttc 2813941 aaaatcggca cagctgaaat atccagcgtg tttctcgttg ctgtttcata tgttctgatt 2814001 ccgcgctcac aaaggataat ttggtcattt ccttgtgaca tgatgtattc agcagcattg 2814061 atgaattcag agatcgttgc agcaagaccg cgcttcagaa gcactggctt tttcacggcg 2814121 ccggccgctt tcagcaattc gaagttttgc atgttgcgcg ctccgatttg aatgacatca 2814181 atgtagtcca gcgcttcttc gatatgagcc ggagttacga tttcactgat aaccgccaga 2814241 tcaaattcat ccgctacacg ttttaaaatt tgaaggcctt caacaccaag cccttggaaa 2814301 tcgtatgggc tcgtacgagg cttaaaggct ccaccgcgca aaattttaat cccttgtttt 2814361 ttcgcagctg cagcgacttc agctacctgc tcatagctct ctaccgcaca tgggccgaca 2814421 atgaatcttt gctggccgtc tccgattttt tcgcctttga tatcaacaat tgtatcttca 2814481 ggttttttct tgcgggagac aagcagcgct ttgctgtgat cttcttcctg aagctctaaa 2814541 ccggctttga atatctcttt aaaaatgtgc tggatggttg aattttcgaa cggcccgtca 2814601 ttgttttcaa tgatattgtt taacattgtg cgttctctga cagggtcaaa tcggttgaca 2814661 ccctgtgctt ccttcgcttt accgatctct tttacaacat tgccgcgttc gttgattaat 2814721 tttaaaattt gtaggtttaa ttcgtctgct ttctgcctta aaagctctaa ctctgtgttg 2814781 ctcatttttt tcatcctttc cctgcacatt cattttttat tttgtagtta tcatgcatct 2814841 tactataagt aattccaaat ggaaatactg aaatacaaaa aattttataa aaactctact 2814901 ttattaccca aacgctttta agtgataaag taatctatga agctatccta catgatgtga 2814961 gggcaatgtt caagggtttt ttacaaaaaa aagcgccaga tgatatctgg acgctttttt 2815021 ctatgacaaa tgctgctcaa tagcggcttc tgtaatttgt gaatgtgagg tatgccattt 2815081 cacttcaccg ttctggatga tgaatatctg agggctttca tgcttgaccc catatgtttc 2815141 tgcaatgaaa ttggacagcg gccgggcttc ttgtacttga agatagtaag ccggcacatc 2815201 ctcatgctga tttgcaaagg catcaaactc atgaaatgct gcctggctga tcgggcatgt 2815261 ggtgctgtgt ttcaagaaga cgaaaacgcc ttcctgttct gcaatccgtt taaattcttc 2815321 ctcagattga ataagctgtt tagccatgac tcaagctctt ccttccctgc tcagcgattc 2815381 aactgctcag cctgtttttg tgcatctttc agttcgtctt ttacatcttc tttcgtctgg 2815441 aggacttgat cttttgtttc atcagctgcc tgcatcgctt cttccctcat atcttgcatt 2815501 gcagtcgatg aatccgtttt gtcagatttg gaacggtctc tcaaatcctt taccttgttc 2815561 atgatctgtc cagactgatc cgctacaagc tgtgtgatgt tggaagtttt gtcttttgcg 2815621 atgctgacat attgcgtgcc tttttccttc gcatctgccg tcattttatc agttttgtcc 2815681 cgtaaggcaa cagcctggct gccgagatcg tcgcgaagtt ctttgcctga tttaggcgct 2815741 agaaaaagag ctgtagtggc accgatgatt cccccgatta aagttccgat taaaaaatct 2815801 ttactattaa ttccatcttt gctcatcatt attcctcctc ttagtatttt tttctcttac 2815861 agggctgatt ttttcttttg cttccatttc tcccaaattt ccattgctgc ttgactccaa 2815921 gtgacaactt gattgatctt atcttgattc tctctaactg atgccgatac agaccctgcc 2815981 gcttgtttca tggatgtatt gaactgctgt acagaagctc ccactccttg aacagcatga 2816041 acgaccgtgt tcagcttttc tgatttttcc tgaatatctt cagccaggcg gttggtctta 2816101 tgtaaaagct cggctgtttc agttgtgatg cccttcattt gtccctccag cccttcaaga 2816161 gtggatgcga cgttttttag tgtcagctgc agtgacttca atgttttaga caagtagatc 2816221 actaatacga gaaatgcaac tgcgatgagt gcaacgctca aataaagaat aataatcatc 2816281 tcaaacctcc ttgctgcagg atatactgct gtttacccgt tttcttcaat cataaacatg 2816341 tgtactgggc tgtatacata ctattctccg ttatgtaaga aaatccttta ataagctttc 2816401 ccatcagata aataaaaagc agtgagatca ctgcttttta ttatgccatg acgttttcgt 2816461 aggctctcat atatttttgg atatctcctg ctcccatgaa gatgagaacg gctttatcat 2816521 gagcttttaa aacagatgtg tcatcttctt caatcagctt ggcattatga atttttccct 2816581 ggagatcacc gatcgtcagc tttccggcat tctcacgggc tgagccgaaa atatcgcata 2816641 aatacacaca gtcggcgccg ctcaggcttt ctgcaaattc gtcaaggaac tgctgcgtcc 2816701 gggtaaatgt atgaggctgg aataccgcga caatttcccg atcaggatac ttctgtcttg 2816761 ccgcctcgat tgtcactttt atttctgtcg gatgatgggc atagtcatca atcagcactt 2816821 gatccccaag ctgcttctca ttgaatctgc gtttgacgcc cccaaaggat ttgagagcat 2816881 gcttaatgat gctggaatca atttcttcat aatggcataa cgcaatgacc gccaatgagt 2816941 ttaatacatt gtggtggccg tacgcaggaa tataaaacgt atcatagaac gtattgcgga 2817001 caaagacatc aaaagttgtc ccttccgtgc tttttacgat gtttctggct tgaaaatcat 2817061 tttcttcccc cgtgccataa tacacaaccg ggacgttcgc atggattttc ggcagatgct 2817121 catcgtctcc gcaggcaata atgcctttgt tgacttgaag agccatctct tggaaagcgt 2817181 caaatacatc gtcaatgctt gagaagtaat cagggtgatc aaaatcaata ttcgtcataa 2817241 tcgcataatc tggctgatag cttaagaaat ggcggcggta ttcgcacgct tcaaacacaa 2817301 agtattcgct gttttcattt ccctggcctg ttccgtctcc gattaagaaa gacgtcggtt 2817361 ttgcgttttg gatcacgtga gccagcagac ccgtagtcga cgttttgccg tgtgcgcccg 2817421 taacggcaac actcgtgaat tttttcatgt agtcgcctaa aaacttatga taacgtatca 2817481 ccggaattcc ctcagacatc gctttttcta tttcaggatg cgtgtctggg aatgcgtttc 2817541 cggcgatgac tgtcatgccg ggtttaatat tttccgcgct aaaaggaaga atcgtaatat 2817601 ttcttttttc aagcgctgtt tgcgtaaaaa taaatttttc gatatccgat ccttggacag 2817661 tatatccatt atcatgaagt atttgggcaa gcggactcat accggtccct tttattccaa 2817721 caaaatgata aacagtcata attgtacctc caacaaacgt ctatctgttc cccagtatat 2817781 gacgctcatt tcaatttgcg accgcggcgg ctgaaaagcc tcccttagcg gcgtatttta 2817841 tatgttttgt tatgtttagt atcaggttat ttctttccga ttaaacccag atatcaagat 2817901 ttgtctatgc acagctgctg taaagcggca tagctgttaa atgctctaaa cactatcata 2817961 ccatgtttgg tgtgaaaatg aacccatatt attcgtttat taaatcactt gctgtgatca 2818021 gcacctctcg aggcttgctt ccttttgcct cagagatcat gccttccgct tccatcatgt 2818081 cgatcagcct tgccgcacga ttgtaaccga ttctgaatct tctttgcagg cttgaagtgc 2818141 tcgcactgtt ttgctctaca acaaactcac acgcttcgta aaacagttcg tcctcttctt 2818201 tcagggcaga tccttgtctt acgagctctt cttgttcaaa taaataggtc ggcggcattt 2818261 ggcttctgac gtgggaaacg acgcggtcga tttcccggtc tgacacaaag ttaccttgca 2818321 gacgaaccgg ttttcccgag ccgttttcca aaaagagcat atcccctttt ccgagaagct 2818381 tttctgcacc ggctatatca ataattgttc gggaatcaac ctggcttgag acagaaaagg 2818441 cgattctcgt tgggatattc gccttaatca gacctgtaat gacatcgact gacggacgct 2818501 gagttgcgac gagaagatgg ataccgcacg ctctggcttt ttgggcgatc cgcgcaatgc 2818561 tttcttccac atcgtttgga gccaccatca tcaaatctgc aagctcatca ataatgacaa 2818621 ctaaatacgg cagcttttca cccatttggt gttcagcggt taattgatta aagcggtcaa 2818681 tgtcgcggac acctgaatgg gcaaaaagct catagcggcg ctccatttcc tcaacgaccc 2818741 atttcaaagc agccgtagcc gctttagcat cagtaatgac cgggctgacg aggtgaggaa 2818801 ttttattgta aggggccagc tctaccattt tcggatcaat cagcagcacc tttacctcac 2818861 tcgggtcagc tttataaagc aggcttacta atattgtatt gatgcatacg ctttttccgg 2818921 agcctgtagc gccggcaatc aagccatgcg gcattttctt caagtcgata acaacaggat 2818981 ttcccgaaat atctaatccc agcgcagctg tgagcggtga cttgcttgtc ctgaaagctg 2819041 agctgcgaat catttggcgc aaatcaacca ccttgctcgt gcggttcggc acttcaattc 2819101 cgatcgtgtt tttccccgga atcggcgctt caatccgaat atctttagct gagagactga 2819161 gtttaatatc atcggacaag ttggtgattt tattcacctt tacacccggt tcaggatgca 2819221 cttcaaatct cgtgacagac ggaccctggg ttacatggac cacattggcg cggacattga 2819281 aatttttcaa ggtcaaatca agaagctgac gctgttcttc gatccacgca gtatcatctt 2819341 gaacctgcgc tggcgggaca tcaagcagtg caacattcgg aaatacatag ctgccgcggc 2819401 gctcctctgc tttttgctgt ttatgcgtat ctcttttcag catcatcaca ttaaaaggaa 2819461 cggatggccc tttttgagaa gatgcgcttt gttcagtcct tttctcctgt acaccaggcc 2819521 tttttttcgg ctcttctgaa gcttcgcgag gtttgtctgc gcgaatttcc tgccggtttt 2819581 caagagttgc agtagacgat ttggaaccct gctccatgtg ttcagttttc tcaagctctg 2819641 tatggctgtc tggctgaaca tctatcttcg tttcctgagc ctctcccagg gtgtcataat 2819701 gattatttat tatgctttct gatggctctt ctgattcttt tgccacagtt tctgcttgag 2819761 ccagagcctc tgatgaatac tcatgatcag taaataaagg ctcttcctga cgaatgtcca 2819821 tttgttcttc ttgaacgaac ggggactcag caccttctgc cgcgttttca tgatgattgt 2819881 atactgggct gtctgacggc tcttttgctt tttcatcctc agatactgcc tctgtctgag 2819941 attcaggagc tgtttgctct tcatcaagtt cagcggagaa aacaggctct tcaaatttct 2820001 ctggctgctg ctccctttgt tcttcctcag ccgttgcagg ctcttcgcgg cctacttcac 2820061 tgtctgaaag cccttcagcc gccgtatctg tgagcatctc aggcggtgtt tgctcttcgg 2820121 cttgttcagc tgggaagaaa ggctcctctt tttccggctg ttgaacgcct gactcaaatg 2820181 gcactttgtt acctgacggc tcggctggcc gtttcgccag cgcctcatca tgctccgtat 2820241 cctttctgtt taaaacgcca gaaggctgtt tttcaaattg ggtatccggg aagaaaggac 2820301 tttctatttt ggaatgcgcc tgtgtgtctg aagcaggata gccgcgttca cgttcgatct 2820361 cttctgacag cagtgttacc ttctctttta ccgatttatc cggttcgttc aatgtttcag 2820421 aaggcttttt cggcacatcc tttttaacag atggtttttg attgaatcca tagacaggcg 2820481 aagggatatt tgtcggttta aacggtttct tcgccggctc tgctgcttga tatgtatgct 2820541 gctcttcttc atttctggga cgctctctgt aaggtgcagc acttggacga ggcgcggatt 2820601 tcggttcgtc cgatggtgtg cggcgccttc tcaggtcatg atttttgtat ccgtcaggca 2820661 cgactggaaa acggaatttg ccttttggat attcataata tattttagga tcttccaatc 2820721 tttttaattg tccttcagga tgatgtactt cttgttgctg cggaatttga gcgggttttg 2820781 tctcccgttc agcatcctct tcgctttcgc ctaaaaacaa atcaaaaaat ttatgaagcc 2820841 aactcataat ttatctctaa ctcccttata gttttctggg acggttttta gtataccact 2820901 gctggtcggc ccagaaaaga ttaagctatc agcagaaaca aagccgctaa acaagggctt 2820961 agcggctttt cacatgattc gttttttttg gcggatttat gggagtctaa aactgaaatg 2821021 cgtctcccgc ctcatagtct ccttctaaca caaggattcc tttttcagca ggggcatccg 2821081 gcaaatcaag ctctttcgct gagcagatca tcccgcttga cggaacgcca cgaagctctg 2821141 catccttaat gacaagtccg ctaggcatca cagcaccgac tttggcaacg acaacttttt 2821201 ggccttggtc aacgttaggc gcgccgcaga cgatctgaag cgtttcttct cctacgttga 2821261 ctttacatac gcttaattta tccgcattcg gatgtttttc ttttgattct acataaccca 2821321 caacaaactt cggagataaa tcaacgacta atgtttcttc aacgccgttt ctgtttaaaa 2821381 tctcattcac atcttgcacg aatgtttctg agagcgcaac agggccgttt tcatcaatgg 2821441 tcaagtaaga agacgcattg aaaatgttga agcccgttgt ttcttttgtt tcgttattga 2821501 aaattttgac gacgtcgccg tgtttttcat agcctaattg ttcgcgtgtc acatcttgaa 2821561 gagagatcag gagcgtgtct cccacacctt ctttattata aaaagcgttc ataagtaaaa 2821621 atcctttcta atcctttttc ggacggcttt tcgccaggat aaacaccggt tccagctttc 2821681 cttcattgta caaaaatgat agggcggtaa tcgggacggt gccgcctgca aagaagctca 2821741 tcgacatttg tcctagaata tcataccccg attcattccg gatgtcagca agaatcaaaa 2821801 cgtcctgatg aggaacagag atcgccagct caccttctgc atgctgctta tactcattta 2821861 agatcgcttc gttcaaaatc cggcttgcgt cgtatccgtc gtttgccctg aagaaataaa 2821921 agtaattgcc ggcaaccgta tcctctttga caaccgtcgg cagggaacgg agattaaatg 2821981 cggccgtctc tctgatccgc tcttttgtcc agttttcttt ctcaagcatg cgctggtcaa 2822041 ttaaacggta ggttttcccg agatctagcg cgtaataaat tcttgtctct gcggtatgat 2822101 cgtcataaat gagcgggata tcttcgctgg acttgtccgg gaaggaagtc gagcggatga 2822161 ccggataaat gcgagtttct ttcccggtca tttcctgagc cttcccttcc attgccgtca 2822221 tcgcttcgga gacatagtac acgatctcat caatggcttc gtcttttttc agttcccatt 2822281 ttgcaataat cggcggcaaa tcgagtgtaa tccctttttt agtcgtttga tcctcaacac 2822341 ggagggtgtc tttttctctg tcaaacagaa aggagcgatt ctcgtgctga aggcgctgct 2822401 tcagtatatc tgacagcttc cttgaggtca ttttcaaacc gatgtcctcc tttacgcttt 2822461 agcgagagag tctgttaaaa actgttcaat ttcttctttt gttttgcggt ctttgctcac 2822521 aaaacgattt acttcttttc cttcattaaa caccacaaag cttgggattc cgtaaatttc 2822581 ccactctgca catgtatcaa tgaatttgtc acggtctacg tagtagtagg tgaattcagg 2822641 gaaattcgct tccagttcag gcaggaaagg ctctacaaaa cggcaatccg ggcaccaatc 2822701 ggccgaaaac ataaatacag accaatcatc ctttaccgct ttttccagct cttgagttga 2822761 ttcaattttt ttcatttcat atccctccag ttgtttatgt tcttacatgt tttttatcga 2822821 tactcgtcca tttggatcat accaaactgc ttgaggcaaa accacttata tgcaacgaat 2822881 gaatatgtaa gattggcttt cccattatca ttatcatatt ttatttgcat tatcaagctc 2822941 gtttcgttta acatcgtgta catgagggtg aaatttacag atggatatac ataaggaggg 2823001 atttttatta tggagtttat cgtctattta gcaggagaaa tccacagcaa ttggcgcgag 2823061 gaaattaaag aaaaaacaaa atcactgaag ctcccgatta cgtttgttgg cccgatggag 2823121 aatcatgacc gctcagacaa tattggtgaa gaaattatgg gcgtacagcc aaatgccgtt 2823181 ttaaaggatg acaaagcctc tgacatcaac aacttcagaa ccgccgtcct gatgaataaa 2823241 gcagactttg tgatcgccct gtttggcgaa aagtacaaac agtggaacac ggcaatggat 2823301 gcatcatatg cgatcgcaaa aggaaaaccc ctgattatca tccggccgga atcgctccac 2823361 catcctttaa aagagctttc caataaagcg aatattacgg ttgaaaccgt taaccaagcc 2823421 attaaggccc tttcctatct atttgaaaca gaataagaaa aaagcttgtc gatccgggct 2823481 tactgctcgt tcaacaagct tttatgaaac ctacatattt tctttaatcg catccactgt 2823541 ctgcttatcg caggctgtta caagtttgat gagcatttct ttagcagcag cataatcatc 2823601 aatatgaatg atagtagcgt ttgtatgaat atagcgggaa catattccga taaccgctga 2823661 cggcacaccg ctgttcgaaa tatgaacctt gcctgcgtct gttcccccgc cggatacaaa 2823721 atattgatat ggaatatcat gcgtttcagc catatcaaga acgaattccc tcattccgcg 2823781 atgcatgact gtcgttctgt caagaatgcg cagcaaaaag ccttttccaa gctggccgaa 2823841 ttcatttttg tctccgctca tatcgtttgc cgggctggcg tcaagggcga aaaacaagtc 2823901 cggtttaatc atatgagaag ccgtctgcgc gccccttagc cctacttctt cctgaaccgt 2823961 tgcacccgca tagagtgtat tcggaagctc tttaccgtgt aattccttca gaagttcaat 2824021 gcttaagccg catccatatc tgttatccca tgcttttgat aaaattttct tttcattcgc 2824081 catcgtcgta aacggacaaa caggcacgat ctgctgtccc ggtctaatgc cgattttgat 2824141 ggcgtcttcc ttatcatccg ctccaatgtc gatcatcatg tttttgatat ccatcggtcg 2824201 gtttcgctgc gcatctgtca ataaatgcgg cggtatgctt gaaatcacac ccggaaccgg 2824261 cccgttatct gtttgaattt caacccgctg cgcaagcaaa acttggctcc accagcctcc 2824321 gagcgtctgg aatctgagca gcccgttgtc tgtaatggat gtcaccatga agccgacttc 2824381 gtccatgtgc ccggctacca taattctcgg tgcgtcctct gcgcctcgtc tgactccgaa 2824441 aacacttccc agtctgtcct gaacgatgtc atctgcatat ttggctagct cctgcttcat 2824501 aaaagcacga acctgatgct cattgcccgg cgcgccggga agctgcgtca gtgtttggaa 2824561 aagcgctttc gtttcttgat tcatgttttc ccctcatttc tatgtagtcc ttttatttta 2824621 ttagaaacaa tgaagttttc caagcactct gacccaatct gctcgatcag ccgcgtattg 2824681 cttaacagga tttggctgtt tctgtataat gaaaagtacg atcaaccagg aggtgcttta 2824741 ttttgaaatt gcgtcatctt cttttaggag caggacttgg aatttgtacg gctgtcgttg 2824801 tgagacaata tgtgatgaag ccttatattt cttcagaaaa agcgcttcga attgtaaaat 2824861 ctgcttttaa gcagcggggc ccgattgacg gatcatggat ttacacccag ccggagccct 2824921 acaatattaa cggagaaacg gtacaggtat acaaaaccgg cattacacga tcagctttcg 2824981 gagaattaga acagtatgaa gtcatggtgg atgcgaaaac gggagaaatt gttgatgtca 2825041 ttgatacaat cgcctcttaa caccggacaa gcaaaaaata gaagccgctg cctatgcagc 2825101 ggctcttttt tattatatcg cgcgaatcgg tttgtatacc ggataccaca tcgcatcctg 2825161 cactgcctgt ataatgtctt caggctcttc cgtagcgacg ccttccttca ttgcggtttt 2825221 tgcaacttca acagcaacgg ttgccgaaac agtgcgcaaa tcttcaactt ttggaagcat 2825281 cggcgcccca ggcaccccga cattgaccat acctgcgatt gcccgggcac atgcttcaaa 2825341 catgccgtcg gtaattaatt ttgattttgt aacaatcgtt ccaagaccga gaccagggaa 2825401 gacaagcgcg ttgtttgcct gcccgatatg atacgtaact ccgttatatt caactggcgg 2825461 gaacgggctt cctgtcgtga tcagcgcacg gccttctgtc cattcgatta aatcctccgg 2825521 ctttgcttca gaaagagttg tcggatttga cattggcaaa atcgccggcc gtttcacatg 2825581 tgacgccatt tcttttacaa tttcttcagt gaaagcgccg gaaaccgtag atgtgccgat 2825641 caggatcgtc ggtttcgcct gccgaaccac ttcaagaaga tcaatgcctc cgccgtctcc 2825701 gttccgctga taatccttca cttcatcagc cgaacgggca tacggctttt ggaaatcaag 2825761 aagctgatcc atatcatctg ttaacagccc gttcctgtct atgcaccaga agcgcttgta 2825821 tgattcttct tcactcagtc cctcgcgcac caatgcttcc cgcagctgtt cggcaattcc 2825881 gattcctgcc gttcccgctc cgaatataac aactctgtga tctctcagcg gaactttaga 2825941 cgcttttgca caggataaga ctgcggccaa agaaacagcg ccagttcctt ggatatcatc 2826001 attgaaggta cacactttat ctttatagcg tttcaaaatg cttcgcgcgt ttttcgcccc 2826061 gaaatcctcc caatgcagca atgcattcgg aaatgtttct ctcgccagcg caacgtagtc 2826121 gtcaataaat tggtcataac gttccccgcg cactctggaa tgctggttgc cgacataaag 2826181 cgggtcgttc aagaggctct cctgatttgt ccccgcatct aaaacaacag ccagcactct 2826241 gctcggatca atgcccgcag ccgctgtata aaccgccagc ttgccaatag aaattgcgat 2826301 tcctccgacg ccccagtcac cgattcctaa aattccttcc gcatcagttg caacaattaa 2826361 atcgatcgta tcgctttgat ctttatactg tttaaaagct tctttcatac cgtccgggtc 2826421 atcgattgac agatagagcc ctcgtggttt tctgtattca tggctgtatc tctgaattgc 2826481 cgttccgact gtcggtgtgt agacaatcgg gagcatttcc cctaaatggt catttaacag 2826541 gcggtaaaac agcgtttcat tccgatcgtg cagcgccgtt aaatagacat ttttgctcaa 2826601 atcgtcaggc tgtgcggaat attgttcata cgctcttttc gcctgatcat caattgttaa 2826661 taccttgggc ggcagaaagc cttttaaacc aagttctttt ctttcttcct cagtaaaagc 2826721 aacacctttg ttcaaaaaag gaacagagag cacttcaagg cctcttaatg ttgtttgaat 2826781 gtctccttcg tttgttactc tgaattgttt caccctgcct cttcctttct gagcataata 2826841 gtactaggtt tgcattatta gccggaaaac atgcagggta aacataaaaa tatgctatcg 2826901 cttcattcgc ttaactgact ttttgatgct tccgtcctcc tcccattgaa gggcgcgata 2826961 ctcggcatca tggtaaaaaa taaaccaagc atctttttct gctgcgaacg cctgccattt 2827021 ctgcttttgc gggatagagg tcatcggata atcatcgtaa gccagcaccc atagcggatt 2827081 gcggtgggca tgtgtcggca tcagatctgc catatgtacg gcagtttcac ccgcatcctc 2827141 gcatatcagg acactgtgtc cgtcgctatg gcctccggtg tgatgcattg taataccctc 2827201 tgtgatcgtt aaggtgtctt caaaggtttt gacttggcca gctacagcct cccaattttc 2827261 tttccaatac gtatttttcg acctgatatt cggatggcgc atttcgtccc attcaacagc 2827321 tgatgtataa atcactgcat tcggaaagac agagacgagc cgttcacctt catattccgt 2827381 taaaccgcat gcatgatcaa aatgaaggtg tgtcattgcg atcacatcta tatcggcaac 2827441 cgttaatccg agtgcagcta atgagggttt cacattcgac tcttgtgtca cgccatagtt 2827501 tcgtttttgt ttatcagtca gcttgccgta cccaattccg gcgtcaatga tgatattgag 2827561 cccatccttt tgaatcaaaa tagggtctgt tcttagttca atctggtttt tttcattgac 2827621 tggatatttt ttagaccaaa gcggctttgg cacaacgccg aacatggcgc ctccgtccat 2827681 atgcgtcacg cctccgtcaa gccaggtcaa cgtgatgttt ccaattttca ttgtttccat 2827741 tttcaccccc ccctatcatc atggtagcaa acggcccata aaaaaaacag actcctgtca 2827801 gagtctgtct ttacgttctc cattcaacct cagcccgata gatcggctgg ccgagtgcag 2827861 agaatttttc ttcatattct gtcataatat tgccttccag attgctgtta tgcaaatcga 2827921 gactgacgta tgtcagcagg aggccgtact cagagaagct cttcaaagag tactcaaata 2827981 aacctcggtt gtccgtttta aaatgaatcg atccgccttt gcccattact tcttcatatt 2828041 ttttgaggaa gtgggaatat gtcaggcggc gtttttcatg ccgtttcttc ggccaaggat 2828101 cagaaaagtt caagtagacc cgtttcactt cccccggctc aaacacatcc gtcagcgtgt 2828161 ccgcatctat attcagaagc tttacattct gcgcttcgct gtcttttact ttttggacgg 2828221 ctgtcacgat gacgctttta aataactcaa taccaatata attgatgtcg ggattttgtt 2828281 tggccatacc agaaataaat tggccttttc ctgtaccaac ctcgatatgg atcggattgt 2828341 cgttgccaaa cactgtgttc catttccctt tataatcagc aggattgctg atggcaatat 2828401 ctgcgttttc agccaaaaag tcatcagccc aaggcttgtg gcgcattctc atatgattga 2828461 cacctctatc tattatttcg actaacaaca taccatgaat taaaaagacc cgcaagctcg 2828521 tttttccagt gtatctctct taaggccgag cgcataaaaa aagagggtcc cgtctgctgg 2828581 aacactcctt tcccatgtat aaaaacgctc tgttttgaac aatttaaccc gtatgatact 2828641 gaagggatgt gtaccgttat gggtttacat tatgagcatc aagttcattt attgaaggat 2828701 atattgactg accatcaatt ggactgctgc ggaacagtcg cagagtacga gcagcttgag 2828761 cgtgtgatta aatcactgat ggcaaacacc gagcttgatt caaatttcaa aaacgtgctt 2828821 gaagatgttt accgctacag ccaatcagga atatcgtcca aatccatcga ctcacacata 2828881 caagagcatc agaacagcct gtctcaatgg gtagagcaaa tggattcgta ttcctgatta 2828941 atcaacaatt cgtttcatga ggatatgcag ctcttccatt gcatcatgaa attccttatc 2829001 attgcctttt gctttatgcc aggcaatgaa agtaattgtt tcagataaca cataccaagc 2829061 cattcgcaac cgaaggcttt ctgtcagctc tatgccgtac atgctcagcc agctctccca 2829121 agctggcttt tcgacgtagt ggtacagcaa aggcccgagg tccatcgccg gatcagcgat 2829181 catggcgccg tcccagtcaa ttaaatacag ctggttgtct tcagacaata gccagttatt 2829241 atgattgaca tcacaatggc aaacgacttt ctcaccgaaa tgcacttcat gcaggtgttc 2829301 ttccaaatac ttgatccctt cttgaatcag cggcgaagat tgctgcacag caaatacagc 2829361 ctgcttcagc tgagacaaaa gagcccccgg gttcagcggt tcttttccaa gtctcttcag 2829421 catgtccagc aaggcttttg atgtgtgtat tttacgaagc aattcagcaa cgggccgtcc 2829481 gctcatgtct ttaggcttca gctctctgcc ggtcatccag tgctgggccg taatgacgtc 2829541 cccattttcc atccgttttg tccaaaccag cttcggaaca atgccttcgg cggataaaac 2829601 agctaaaaaa ggtgagctat tacgttttaa aaaaagctgc tgcccgttat gtttcgcata 2829661 atatgcatct cctgtagctc ctccggcggg gaagatctcc caatcgctac ctagtaattg 2829721 tcccaaccag ttcatatcaa tgttcaaccc atcatttctt aaaatatttt agaattaagg 2829781 ctaatcgttt ctagtctatc cagcgaatgc ctttttcgta cgaatcgtat aaaaataaaa 2829841 aagacagcta ttgagagtct catatgctaa tcaatagccg tcctttaaat tttagcgcta 2829901 tagcacaaac ttcgtcaagc aaaactctta agatctgatg ctaaatataa gataaccgtt 2829961 ccgatgccgt ttactgcaac cgttttcttg atttctgttg ggtcttcctg aaatcctgat 2830021 ggatcacata aaagccgata aggtatgtcg tttggcagcc tccactcgac ggagtctgga 2830081 ctcgcgtgat ggataacaat gatatctttc cattcgtcaa cctcgtcaag atcataaagc 2830141 ctgtatgcga taaggtgttc ttttagcgtc aagcattcaa gatggcgctg gatgtctgca 2830201 gcggacctaa gacggaatgc aggatgcgct tttctcagcg agatcagcct gcggatatag 2830261 tgaacatctt ctttgaatgt ttcacggcga tcccagtcga gctggttgat gctgtcactg 2830321 gattgatagc tgttttccac tccctgcttc gtccggaaaa attcctggcc gctgtgaata 2830381 aacggcaccc cttgggcaag caaaataatc gcggctgcaa gcctttgcct gcttcgcttt 2830441 cggctgtcat tttcttgagg aagcgcaaag ctcattttat cccaaaaggt gtgattgtcg 2830501 tgtgattcga cataattgat ggactggctt ggttccggaa caatcggtgc taatgccttc 2830561 catccggaag acccggcaat tccatgcatc acagcttgtg ctgattcacc gttgccgagc 2830621 gcaaaccctg ttgccttaag gtgaaaggtg ttccctttta cagcgtcacg aaacatatca 2830681 ttaaaaaagc cgatgcccgg cattcttggc gcgttcgcca aagcagcttt ctgttcatgc 2830741 ggcagcggtg tagccaggtc ccacccttct ccaaaaagca ggattccggg ctttgcctta 2830801 gttgctttct ctttcatata aagcacggtg tcaatatcta aaatcccgag gagatcaaag 2830861 cggaagccgt caacattgta ttcttcaagc caatagacca cgcaatccgc aatgaatttt 2830921 cttgccatcc ttctttctga tgcaatatca ttgccaacgc cggtgccgtt tgatggcatc 2830981 ccacattcgt cgtgccggaa aaaataaccg ggcactgtct tttcaaaggg ggaattctcc 2831041 ctcttataca catggttaaa aacaacatcc agaatgactc gcagaccgtg ctgatgcagg 2831101 gtattgatca tttgtttcag ctctgttttt ctcgtttgag gatcatgagg atttgaggca 2831161 tagcttccct ccggggcaaa gaaatgaagc gggttatatc cccaattgta tgcatcaagc 2831221 ggcttctctt catcaactcc ggcaaaatca ttcaccggca gaagctccac atgtgtcaca 2831281 ccaagctctt ttacatacgc taatcccgaa gaactgccat ttgcggtttg tgtatcagtt 2831341 tccgtcagcg ctaagtattt tcccttgttt atcatgccgc tgttttcatg gatggagaag 2831401 tcgcgaagat gcgtctcata gatgacggca tccacagggt gtgagaatgg tttaagagga 2831461 gcagtccatt tcatttgatc cgggcgcaag acgacgccct tctctccatt tacagtcaca 2831521 gccttggcat actggtcaac tgtttccatc cattctgaat tgttgcagat gcaaaacaaa 2831581 tactcatatc cgtgaaggtc acctgtgacc gtaacggcat agacgccttt ttccaagcga 2831641 gtcatttgga atgtgcgccc gcttttattg gggtgtgaaa gcttgacagc agctgaggtt 2831701 gcagcaggcg cccatacttt aaatacggta tgatccgcgg tataaacggc gcccagctct 2831761 ccgtcataat aaaattcgtc atcaaacgct gccgtccgga tgaccgcgcc aatttggaga 2831821 tccgttttgt ggccgctgga tgctctgacg caatggattt ttccaaatgt cacaggatgg 2831881 tcggatacgc agacgtactt gtattttgct tcaagggagt attcctccct gacagccaga 2831941 ggaaaatctg ttatttctgt ctcaagccga aacggcggtg tcatgatttc cttttgttca 2832001 gcaggaatca gaacagtaat gatattcatg tcatcgacat acgcttcgaa gctgcggcgg 2832061 atgctgacca tcggaagctc tctcctccaa acacgtttat gttttgattc ttaggggtga 2832121 aggactagat gccagacgaa acggggtagt gcccatgatt tctccgtcag catggaacgg 2832181 gattttgtcc ttcgtgtaaa atgtaatgtc cttcgcttta aacatcgtaa cgccatccat 2832241 ctttgtatgt tttccaaatg ccatgagaca taaaagccaa tattttttca aaaacggctg 2832301 gttttcaacg attacgatat caaatgtctt ctcgcgcgga tttgctaggg gcgccgcctt 2832361 catgcctccc ccgtaaaacg gatggttgga tacaacggca aaccagacat catgaaattc 2832421 gcgcgtctcg tcttccgtcg tacaagctaa tgtaaacggc ttaaaggttg ccgaagcgtg 2832481 caaatgagaa agcggataca caagaaatcg aaggcggaga aaaagaaaaa cccgtctcaa 2832541 cggaaattcc atcgcctttt tattgacata tgcgtcaaac ccgatcccga tatgattcat 2832601 aaaataaaga atctgtgatt tatcctgaag gaaattgacg ctccctaaat gaaaggttct 2832661 tgttaacggg cgctttacct tcttgatttc ctgtatcaga tcgatttttt taatagagaa 2832721 ccctcgcgaa aaatcattat acgcgcccgc cggcacaaag ctcagctcaa tatcgtcaac 2832781 atctttcagc ccgttgacaa cttcatgcat ggttccgtct ccgccaatga cgatcaggcg 2832841 cttcagctta tattcctgta tcgttgaaat ctgtctggcg agcacctcgg cgtgtcccgg 2832901 atgttcagtt aaaaatgaac ggtgctcaac ctttcgtttg atcaattctt tttgaatgga 2832961 cttccaaaca cgcaggccgt ttcgatgtcc tgctgtcgga ttaataataa aaaaccaatg 2833021 gctcatcttt ctcacctgct tatgttatga gaaaaccgct caaatcgttc tcttttactc 2833081 cagccactcc tgtctgcgat aggagtcaga catgcagtaa gacaatagag cctttgcagc 2833141 ctttacctga tgatgtttga tcggagcagt gtttttcttc tgccgctcaa tccattcttc 2833201 cgcgctccgc ttatccgcta tttctaagcc gtatggcggc tccgggtaat cgatgtacga 2833261 cgttctgctc agaagcaatt ttcgaaccgg aatctcagcc tgtttttcct ttacgatctt 2833321 tgacacaacc gagtccgtac gaaacaggct aagccctgga tttaacactg atgcagtctg 2833381 agaggctgtt ttcttgtccc aaaaacgatt tttagaccct atgtagacac tgtcttcctc 2833441 agcctctaaa aaagaaacgc aataaatttc cagaggagaa ataatcacaa tgcttaattc 2833501 aaccgccgcc tgctgaattt tcagcacagg cttatacata ataaaataag aatcaggcag 2833561 ctgctgggtc agataacgca aaatgcggtc ctgcttcact tggtttgaga gttgagatat 2833621 ttctgaaaga gtagagcttg cccatttgag ctgaaaatca tataaatgcc ttttataaaa 2833681 agaagcaagc gccaccctgc tcttcgggag ccttacatga atatcttctt cgtcctcaaa 2833741 ccattggtgt ctctcttctt gtatatcggc ttttatctct tcttttcttc ttttcaatga 2833801 aaattttttt cgtttctgca ccggttccgg ttcttcagca ctggcttgcc tttcttcatg 2833861 ctggcgctcc gctgcttcta ctagtgaaag ccagcgctct tttttcaaac gtacaaactg 2833921 gttgatataa tggtacggat caagctcata tctcgatata taatcatgaa ttttgatgat 2833981 ttgtgccatg tttgtttctc cactccgcaa tgaattaaga taattgaaat ttgaatattt 2834041 cctcgtattt tggtgattgg ttcaagtgta tttgaaagag cgaaaatcgt tcagccatca 2834101 tcgaaacctc gccgctttca aacggaacat gagctggaaa tccatcttcg cctgtccatt 2834161 ttcttgccag cgtcatatga ggatgatacg gtcttttttc cacttgaaag ccggcctgaa 2834221 gtacagcctg cttcgtatgt tcccgcagtc tatcaagcgt tttgtttttc tttggctcca 2834281 gatgtaaaac gcgcggcttt ctgcggtcgc cgaatacatc tatcttgcca aacttaattg 2834341 aaaatggatc aatttctgaa gcaatctctg ctagcgaacc ttcaagcttc tttatttgtg 2834401 tctcatccgc cgctccgaga aaaattaacg tgatatgata gtcaagcggg tgcacccatt 2834461 tttgaaacgt caatatcggt tcgtttttcg cagcctggta gatcggattt gcaattccct 2834521 caggtatggg aacgccgatg aaataatgag gccgtatatc tggcatccgt ctgacactcc 2834581 cttctttgac agctattatt ttatcaataa agaggctgtg cggatagagg aacagtgtat 2834641 gaaaacactc tcgcacaaac gtttattatg ttaggatatt atatgacact tgttttattc 2834701 agaaaggaat gacaatgttg aaaatcgttg caaacacagc tgatctgata ggagatacac 2834761 cgctagtgag attgaatcgg cttcagccgg aaaatgcggc acaagtctat ttaaagcttg 2834821 aatttttcaa tccgagcggc agtgtgaaag acagagccgc ttatcaaatg atcatagaag 2834881 ctgaacaaaa cggtttactc aagccgggat cagttattat agagccgaca agcggaaata 2834941 ccggcatcgg gctcgccatg aatgcggcag cacgcggata taaagcaatc ttagttatgc 2835001 ctgatacgat gacgaaggaa cggatcaacc tacttaaagc ttacggtgca gaggttgtat 2835061 taactcccgg agaggaaaga atgccgggca gcatcaaaaa agcgaaggag cttgccgaac 2835121 aaattccgaa cagctatatt ccaatgcagt tcgataacac tgctaatcct gatgcgcacc 2835181 gaaaaacaac agcgcctgaa atcgcccggg caatagagga aatcggaaaa ccgctcggcg 2835241 cttttgtagc ctcctctgga acgggcggaa ccattaccgg aacaggtgag gcgctcaaag 2835301 agctttttcc ggatatcacg gttcatgttg ttgagccagc gggttcgcct gtattatccg 2835361 gcggaaaacc tggcgcgcat aaacttgtag gaacgagccc aggctttata ccgccgattt 2835421 taaatgaaga cgtttatgat gaaattatca aaatctctga tgaagacgcg tatacgacga 2835481 caagacggct tgctgctgaa gaaggaattc ttgtcggtcc ttcatcaggc gctgcctgct 2835541 tcgcggcaat cgaaacagcg aaacgcctct ctcctgacaa agttgtggtc tgcatgacag 2835601 ctgatacagg agaacggtac ttatcaactg atttatggtc atttatttaa aaaaaggact 2835661 ggcttcagca gaagccggtc cttttatttt gcaagctcgt aaatggcctg agcatataac 2835721 gctgtcgatc tcagcaggtc atcaatttcg atatattcat ccttttggtg tgcgctgtca 2835781 gggcgtccgg ggaacagcgg gccgaacgcg acaccggctt ttaaggatct cgcataagtc 2835841 cccccgccga ttgagattaa atcagctttt ttacccagct ggccttcata aaccttttgc 2835901 agggttttga ctaacggatg atctgcggac acgtgatgcg gcttgctgtc tttgaattct 2835961 cccagctcaa attcagatgc gctttcgaat gtatcgcgga tcactttgct ttctgctgtc 2836021 acaggatagc ggatattgat cccgagctcg cctccttgcc cttctttata gcgcagtgtt 2836081 ccgacattta atgtcagctc tccgctgatt tcatcctcac agtcgatgtc cagttttttt 2836141 cctcttgtat cacctgagaa cttatctgtc acaacttgca caaaccgctt tcctgcatcg 2836201 tcaagctcag tctgctggag aaattcgcac aataaaatgc cggcattgat cccattgttc 2836261 ggttccatcg catggcagga aagaccgtac atacgcaaaa tgagctgtcc gttctctatt 2836321 gcagcttccc ctttttggtc cgtcgtgcgg agcatgtctt taaatgaaga cagaatctct 2836381 tcatttttcg gcccttcaat gacagcttcc gcagcgtcgg gcaccatgtt taagcgaagg 2836441 cctgattgaa acgagacaag cactgccttt ggttcagctt gatttgggcg gtgcggaata 2836501 agtaaagaag catcgatgat ccctttttcc gcattaatga tcggaaaatc ggcgtcaggc 2836561 gcaaagccca ttgttggcat ttcttcatgc ttgaaataat gctctacgca tctccaatca 2836621 ctttcttcat ctgttccgat aatcattctg actcgcttgg acaggggcaa attcatgtct 2836681 ttcacgattt tcagcgcgta gaatgccgcc attgtcgggc ctttgtcatc aatggcgccc 2836741 cttgcataaa tccgtccgtt gcggatttca gctgaaaatg gatcactcgt ccacccatct 2836801 cccggcggca cgacgtcaac atggcaaagt acgccgataa tgtcatcgcc ctccccccat 2836861 tcaatatgac ctgcgaagcc gtcaagattt tttgttgtaa agccttcttt ttctccaagc 2836921 tccagcaatg aagtcaggct ggcatttacc ccttctccaa acggtttacc gggtccggcg 2836981 gttgtttcgt ccatgacact gttgattctc aaaaattcct gtgtatcacg aattaaatcc 2837041 tctttttttc tgatcacttc aacttcccag ttcataatga tcccctttcc gcaagaaatg 2837101 acttgcaaaa accaaataaa acgaataata ttaatggtgt tttgttaaaa cgttcgtaat 2837161 tggaggatac tatgtttcat ctaaaagagc agcaaacatc cataaagcaa gaaatcatag 2837221 cagggctgac gacctttttc acaatggtct atatcgtcgt ggtcaatccg gtcattctgg 2837281 ctaacgccgg ggttcctttc gaccaggttt tcaccgcaac gattattgcc tccattgtcg 2837341 gaacgctgtg gatggccctg gcagcaaatt atccgattgc tattgcgccc ggcatgggct 2837401 tgaacgctta tttagccttt catgtcgtaa gcgcaagcga tggcggcatc acgtacgcaa 2837461 cagctttcag cgcagtattt acagcagggg ttctcttcat tattctatcg ttaacgcctt 2837521 taagaaaaca acttatagaa gcgattccaa acaatttaaa atacgggatc acaacaggga 2837581 tcgggctgtt tattgctttt atcggtttgc gtcaagcggg aattgtggca gctgatgagt 2837641 caaacctggt cactctcggc aatctgcatt cacctggtgt tatcttaacg ctggtcggcc 2837701 ttttgatcag cgtggtcctg atggtgctga atgtaagcgg cgctttattt atcggaatgg 2837761 cagctaccgc tttgatcgcc tttttcaccg gtcagctcca tttttcaaag ggatttatgt 2837821 cgcttcctca tttgccggaa ggattgatga tctcaaatcc atttaccgct tttggcgatg 2837881 tcattcatca cggcctgtac gctgtcgtct tttcttttct attagtcacc atttttgata 2837941 cgacaggcac gatgatcgga gttgccgagc aagccgggct gatgaaaaac aacaagctgc 2838001 cgaacgtgcg aaaagcgctg cttgctgatt caaccgcgac gacagtagga gctgttttcg 2838061 gcacaagtcc gacgactgca tttatcgagt cttccgccgg tgtcgcagcc gggggaagaa 2838121 cggggcttac ggctttgact gtcgcggtga tgtttgcggc ttcaatgttt ttcagtccgc 2838181 ttgtcagcgc cttgtcaggt atagccgcca tcacctcgcc tgctttgatt atcgtcggca 2838241 gcctgatgat gggctcagtt tccaatatga actggaaaga gatggacgag gcatttcctg 2838301 cgtttctcgt cattctagcc atgcctttga cctcgagcat ttctacagga atcgcgcttg 2838361 gctttatttc gtacccaatt gtaaaagcgg cgcggggaaa atggagagag attcatccgc 2838421 tcgtcatcgt tttcgccatt ctgtttttca tccagctgtt tattttataa ggatagacca 2838481 aaaaacccaa acgtcgccgt ttgggttttt tatgtaaaca ataaagagac agcggccgct 2838541 aaaaaacaac aggcggcaaa cgcatagtgc aggatgttga tacagctttt tctggcccga 2838601 taatattcat cactttcctt atcggtgcca attaaaaaag gggcatccat gaccttgtca 2838661 aaaataagcg tcaggatata acggcaaacc cctgtgtata ccagcagcgc aatcaccttc 2838721 agccaaattg gggaaacaaa tatgagaaca gtgaaagctg acagtagcat gtacatctgc 2838781 cttgcatact cgccattcct cagcataact ttaaaaaaca actccttata gcctgtgcag 2838841 atcgttcgtc ttttaaatat cctttttgaa tttcggtata ataatggttt tcttctcatc 2838901 ctgtctttta cttttggcat tcccgcctcc tgactcatca tcatcacaag tcctgcaagg 2838961 gcaagcctgc tttttttctc ttcagtcacc tcagcttcaa aagccgtgaa cgaggctgtc 2839021 tttttcaaac tgcggataac tgagaaaaac aaaaataaaa tgccaaaaag cgcaagcaag 2839081 tgccgctcag taaaaacaat caggatagca gaaccagcaa aaagaatagc tctgacaagg 2839141 gtatcgccaa tccatctcga aatggagcgc ggctttctga tcctgtcttg ctttaaggat 2839201 aaaaagaata tatgaaggcc aaacaaataa cacaatagag cagtgctttc tgcgaatgtg 2839261 atgagaacag aatgactgat caagggaagg acaatgaaaa agagaagcag ccatttagcc 2839321 agcgtggcca gaaaagaata caaaagcgca taccgtttga gctgatagat gatttccttc 2839381 ttttgcagca aaaacacttt gtccgcttcc attaaaaatg tacgaatcga acctgtaaac 2839441 atgatcagca cacacacagc atacagccat ctccattccg ccacttcaga ccactcataa 2839501 agaaggcctc ttccgttcat caaatcaata tactgataga tgacaaaagc aatcgccggc 2839561 aaaacgatat agagagcgac tgtccagtca atgaccgcat gcaacacttt aaactgatac 2839621 ttataatagt caaacagcct tcgaaaaaag agcgtacgcc cgttcatagc cgatcacctt 2839681 gaactgcctt ataaaaacag tcaagcaatg actgcccctc taatccggtc ttgtcctgaa 2839741 catcttttaa cgtgccttgg agaaataatg aacctttctc aatcatataa aaccggtcac 2839801 agattttttc cgcggtatcg agtacatgcg tgcacataag aattccggct ccacgttctt 2839861 tttcagcctt aagcatgtcc acaaagcgtt tcgtcgatat cggatcaagg ccgataaacg 2839921 gttcatcaat cacatacata tccggcttag agagaaaggc ctggataagc attagttttt 2839981 gctgcatgcc cttcgaaaag gtgacaggca gctcatgttt gacatgatct agcgaaaacg 2840041 tctgcagcag gctttgggcc cgatgcgcaa attcactctc ttcaatgccg tgaagtgtgc 2840101 tgatcagatc caaatgctcc cacagcgtca gttcttcgta gaaggacgga tgctccggaa 2840161 tatatgcaaa tgaacagtcg ttccaggcaa tatgcccttt aaaatcttct gaaaggccga 2840221 gtatcgcctt gattgcggtg ctttttcctg cgccgttagc tccgatcagt ccaaccagtt 2840281 ccccttttct gacttccaga aaaacatcgg tgagcacttt ttttcggctt gtatacccgg 2840341 cctgttctat tgaagcttca agcaaatttg tcaaaactca ctcacctcca aaatttacta 2840401 cgaaatagaa taaaaaaagt ttctttaacc ataataatat tgagccgaaa tacatagtaa 2840461 tccaacaagg atggctgccc aacgcgaaat tggaaaaaat taataggagt tatccctaga 2840521 ttcatcactg caatatcgtg tataatgagg gcgaattatt ttaacaatta cagatgtctg 2840581 cctttgttgc tatttcgtac gcagttgata gtcgtgagtt gtggttagtc aagtccatcc 2840641 gatcttatga tagggagtgg ttttttgaaa ccttcaacaa accgtatgct aactcgaatc 2840701 aaatcagttt acatgtttat tcaagaaaaa ggtcttgtga caacacagga actggttgac 2840761 gaattcggca ttacacctag aacgattcaa agagacttaa atgtgttggc atataatgat 2840821 cttgttcata gtccaagccg tggcaagtgg gagacaacga gaaagaaagt aaagattacc 2840881 tcataaattg aaaattacat agggccgcct gagagcggtc cgatagataa cagggcgaag 2840941 aaactactga gccttgtttt tgtgtgctta taaataaaac cccgcattcg gtatgcgggg 2841001 tttttgtcat gcttgcggct catttagcaa atgaagctct tcctctgtca gctcacggta 2841061 ttctccgggt gccagagcgg gatctaggga aacgcgtccc atcgaaagcc gcttcagata 2841121 aaccacttca ttgccgactg cctttgccat ttgcttgacc tgatggtatt ttccttctgt 2841181 aattgtcaga tatataacgg tattgccact gtcgtttgtt ttgatttccg cttttgccgg 2841241 ctttgtttta tagccgccct ctatgtagac acccgtttcc aaatcggaaa tgtcttcccg 2841301 agaaatctgt gattttaaat ggacttcata cgtttttgga acatgctttt taggagaaag 2841361 gagccgatgt gcgagctggc cgtcatttgt gagcagcaaa aagccctctg tatctttatc 2841421 aagcctgccg gctggaaatg gctcaaatct catctcctcc ggcgtcagca gatcgaccac 2841481 tgtttgctgc cggctgtcct cagtcgccga cagcacgccc tgcggtttat tcatcataag 2841541 ataaatgaac tctcgataat caaccggttc cccgtatacg gtcacctcct gcgtatcagg 2841601 atcaacgtgc tcctttacat ctttggcagg tttgccgtcg atcatcacgg ctccagcctt 2841661 cacaacggct ttgacttctt ttctggaacc atacccgctg ttggcaagca gcttatcaag 2841721 tctcattccc aatctctcct ttataaaaga aagcccgcag catgcgagcc ctcagtttca 2841781 tcatatctag ttcatcagcc tgcatgtctg cctttcctaa agaaacctgg caaacggcgg 2841841 cctaaaattt tctgcaaaaa tcctaatcgg tagccgcaat acaggtagac agctccgcca 2841901 acagcggccg cgatcaccac aacaatcgca gcttgcatct ggccatcctg ataggaaata 2841961 aagaagccta atacccactg cacgattttc acggcaatac ccataatggc tgataagacc 2842021 agcatcaaaa cagttcgttt aacaagtatc ttatacgaat agcctgcatg gcgcttaatc 2842081 atgataaacc catataaaag ggaagcgata tatccaagcg ccgtcgctaa aatcgctccg 2842141 tcagcctgca tcagcttgat cagcggaaca ttcagcacaa gcttgatcac gacaccgatc 2842201 acaaggctga caaccgcaaa tttttgctta ttgatgccct gcagaatagc tgcgttgact 2842261 gtaaacaaag agaacagaat tgcgacaggc gaataccaaa gcaaaatgtt tgcccccagt 2842321 tcaggatgaa ggctctctga cccgtaaaag aacgtatacg tcggtcctga caatagagag 2842381 atcccgacaa cagccggaat aattaaaaac aggatcgtct gcatcgtttg attaatctgc 2842441 tgatttaaca gcttatagtt tccgcttgta aacgattcag taatcgttgg aattaatgtc 2842501 agtccaaaag cagttgctag ggaaaccggg atcatcacga gcttctgaac atacagggtt 2842561 agaatcgcaa gcatgtcctg gctgatggct tgatgaccgg cttcaatcat cgctttgtta 2842621 aacgtatttg tatcaatata gttatacaaa gggatggcta gtccgacaaa aacgtacgga 2842681 gcagcatagc tgaacagctc gaaaaacatt ttcttgtagc ttaggtttgc tgtcggaccc 2842741 gtattcggca tcatcgccag caggctgccc ttccgtttgt tccaataaat ataaagcacg 2842801 accagccctc cgaaggcacc gatcagcgct gcgaaggttg catagcccac agcgatgaca 2842861 aggccgccgt tgaaaacctt caaaatcaag aatgtcgcac tcaatagaaa gatgatgcgg 2842921 acaatctgtt caacgacttg ggaaacagct gtcggaccca tcatttggtg cccttgaaag 2842981 aatccgcgga caaggctcat aatcggtacg accaaaagcg ctaagctgac catgcggatg 2843041 acataaacga catgatcaat tgtcaggccg ttattatcct tgcctcccag cgatatttcc 2843101 gcaaacatcg gagccgatag atacagaatg aaaaaggcta tcattcctgt gactagcata 2843161 accgacatgc ccgccttgag cattttcctg cttgtctcat aatccccttt tgaattatat 2843221 ttggaaacaa atttagaaac agcggccgga aagcccatcg tagcaatatt caaaaataaa 2843281 gtgtattggt tgtatccgta ttgaaataat gcaccgcctg tcgccccgac cataatgctg 2843341 aagggaatta aatagaccat ccccagaatc cgcgatatat atgtaccgag cgttaataca 2843401 aacgtgcctc ttaacagttt gcttgacatg tttcttcatc accattttct acgaagattc 2843461 aacttttcta ttttaccaca actgggcatt tagacggtaa taaatacaaa agcaatcctg 2843521 tgaacattca tgtccgcggc aaaagacgtt taaggagcgg ctttctttcg ctataatagt 2843581 actgcggacg ggtgtccgca cacgaaatga aaagaaagtt gatgataaag atgaaacaat 2843641 atgacgtaat cgtaatcggc ggaggccctt caggcttgat ggctgcgatt gcagcaggag 2843701 aacagggcgc tggcgtgttg ctgatagata aaggaaataa attaggacgg aaactcgcga 2843761 tttccggggg cggccgctgc aatgtgacga accgccttcc tgtggaagaa attatcaagc 2843821 acatccccgg caacgggcgt tttttataca gcgcgttttc tgaatttaat aatgaggaca 2843881 ttatcaagtt ttttgaaaac ctcggcattc aattgaagga agaggatcac ggccggatgt 2843941 ttcctgtgac cgacaaagcc caaagtgtcg ttgacgcgct gttaaacagg ctaaagcagc 2844001 tccgcgtaac aatcagaacg aacgagaaaa ttaaatctgt tttatatgaa gatggacagg 2844061 cagcagggat tgtgacgaat aatggcgaaa tgatccatag ccaggcagtc attattgctg 2844121 tcggcggtaa aagcgtgcct cataccggaa gcacgggaga cggctatgaa tgggctgaag 2844181 ccgcgggcca taccataaca gagctgtttc cgacagaggt tcccgtcact tctggcgaac 2844241 cgttcattaa gcaaaaaaca cttcagggct tatcactaag agatgtagcc gtcagtgtgt 2844301 taaataaaaa aggcaaaccg attatcacac ataaaatgga catgctgttt acccatttcg 2844361 gcctctcagg acctgccatt ctcagatgca gccaatttgt cgtaaaagag ctgaaaaaac 2844421 agcctcaagt gccgatcaga atcgacttgt atccggatat caatgaagaa acgcttttcc 2844481 aaaagatgta taaagaactg aaggaagcac cgaaaaaaac cattaaaaac gtgctgaagc 2844541 cttggatgca ggagcgctat ctcctattcc tgctcgaaaa aaacggcatc tctccgaacg 2844601 tatcgttttc tgagctgccg aaggatcctt tcagacaatt tgtaagggac tgcaagcagt 2844661 ttactgtcct cgcaaatggc acactgtcgc ttgataaggc atttgtcacg ggaggcgggg 2844721 tatctgtaaa agaaattgac ccgaaaaaga tggcttctaa aaaaatggag gggctttatt 2844781 tttgcggtga aattctggat atccacggct acacaggcgg atacaatatt acctccgccc 2844841 ttgtcacagg caggcttgca gggctaaatg ccgggcaata cgcccgttct taatcattac 2844901 tctttaaatc tcttgccgcc aaactcacat ttgaacattc cccgcattca tgttagggtg 2844961 agacttgttt tgtttcacct gattgcgggg taattttaag agaggaatga gctgccatcg 2845021 tacgaccata ctaagcctgc gagcaagata taggcgtaca caaaaaatta gagggtgaga 2845081 aatgttgaaa catatatcta gtgtattttg gattgtgatt gcaatcacag ctgcagctgt 2845141 attatggggt gttatttctc ctgacagcct gcaaaatgtg tctcaatcgg cacaagcatt 2845201 tattaccgat tcatttggtt ggtattatct tttagttgtc tctttgtttg tcgggttttg 2845261 tctctttttg attttcagcc cgatcggaaa aatcaaactc ggaaagcctg atgaaaaacc 2845321 ggaattcggg ttattatcat ggtttgccat gctgttcagc gcaggcatgg gaatcggctt 2845381 agtattctac ggtgcggctg aaccgatcag ccattacgca attagctctc catcaggtga 2845441 aacagaaacc ccccaagcct tcagagatgc actccgctat acgtttttcc actggggttt 2845501 gcacgcttgg gccatttatg ccattgtggc attatgcatt gcctatttcc aattccgcaa 2845561 aggcgcaccc gggttaatca gcagcacact gtcaccgatt ctcggggata aagtaaacgg 2845621 accgatcgga aaggccattg actgtattgc agttttcgcc actgttgtcg gggtgtcaac 2845681 aagtcttggt cttggcgcaa cccaaattaa cggcggtttg aattacctgt tcggcattcc 2845741 gaatgcgttt atcgtccaat tggttttaat cattattgtg acagtgctct ttttactttc 2845801 tgcgtggagc ggactcggaa aaggaattaa gtatttaagc aacacaaaca tggtattggc 2845861 cggattgtta atgttgttta tgctcgttgt cgggcctaca gtgctgataa tgaactcatt 2845921 tacagattct atcggacaat acattcaaaa tatcgttcaa atgagcttca gactgacacc 2845981 gaacgatcct gaaaaacgcg aatggattaa cagctggacg attttctatt gggcatggtg 2846041 gatttcctgg tctccatttg tcggcatttt catcgcccgt gtatccagag gccggacgat 2846101 ccgcgaattt ttaatcggcg tcttggtgac accttgtatt ttgacatttc tatggttctc 2846161 cattttcggc gtatcagcca tggatctcca gcaaaaaggc gcgttcaatg tagcaaagct 2846221 gtccactgaa acgatgctgt tcggaacact tgatcactat ccgctgacaa tggtgacatc 2846281 gatccttgca ttgattctga tcgcagtatt ctttatcacg tcagctgatt cagctacatt 2846341 cgtgctgggc atgcagacgt cgtacggttc tttaaatccg gcgaattctg tgaaactcag 2846401 ctggggtatc attcagtccg ccatggcggc tgtgctccta tattccggag ggcttgccgc 2846461 tttgcagaac acagcgattc tggcagcgct gccgttttct atcgttatcc tgctgatgat 2846521 tgcctctctc tatcaatcgc tctcaaaaga aagaagagag atcaaaaaag cggagaaact 2846581 cgataaacca agaagtccaa gagtgaaaaa agcatattaa caaaaaagat ctttccgcgc 2846641 ctgcggaaag atctttttat ttgcgatata aaataagggc ggaaaaacag taaagctgct 2846701 cgccgtctgg gtcgcacgcc gccgaaaccg tatatttgat atctatcagc tgctcctccg 2846761 atatcccttt taaaaatgaa ttgatttccg tttgtaagtc tttttcatgc tcttcatcaa 2846821 ataccgctac cttcagcatt ttatccgctc tcctttctct atcaatctat tccgtttgga 2846881 acagcgttat gatagagaaa tgatgattat ctcgtttccg gataaaaagc tttccgtata 2846941 tgggatttcc tctgtggctc gccgccgtgc tgctccactt tcagcagcac ggcataaaca 2847001 atgcgcatat ggcagtagct gataaggctg acgctgaaaa aagggacaat gcccggcagg 2847061 tacgcaagca agaaaaagag agcaacagtc agcgcaagca tagtaagcgt atattgcaaa 2847121 tacgccacac tgagcaagag cgaaaatttc acatacagac gttttttcca gtcaaaatgg 2847181 acaagcagcg gaaacacata aaaaagcatg gatacgaaca aaaagccaaa tatcataatg 2847241 gcgaagcgca ggatgtgcag aaggaaatga cttggataaa ttaaggccaa atcaatataa 2847301 atgatcactc cgatgagcgc cagtacagcg ccgagcagat ttgaacgaaa aaattcaccc 2847361 ttgtattcct gccaaaacgt tttgagcacc ggaacgttgt cctgcccctg gatccacttc 2847421 cgcatgacag cgaataaagc cgcggtcgcg ggcatgatgc caaacacgcc gagaccgagc 2847481 aacgtaaaaa acagccacag caagtttgta tacgcaaatc tcataatcca ttcgcaaaaa 2847541 cgcagcatcc gtcccagtga gccatcatgt tccatggcgc cccctccttt tttgcattat 2847601 acattctgca tctgaaaaag ctctttcatg ccgatcggct tcttttcggc aaccgagcgc 2847661 cacattccct caccaaccgc gatggagtag gctccagctt cagccccggc taaaatatca 2847721 tagcggcgca gcgggtcttt ccctaaaaaa agatcctcaa gcaaaagcgg atcacctccg 2847781 ccatgccccc cttcattttt gaccacttgt atcgtctgct ttgattcaaa aagcggatag 2847841 tattcgattg tctgctcagg aaaagcaaac ggaattctgg aaggttcgtg aaattcattt 2847901 gattcaatac gtccttttgt gccgttgatc gtcagccggt agccttcata cggggccgaa 2847961 aaaataatcg agtagcttaa cagtgcgccg ccatcatatt tgactgccgc cacgtacgta 2848021 tcctcgatgt caatttcctc gtcaaaaata cacgcgtcag gcctgtatgc agtatataag 2848081 ctggactggt ctcctgcttc aagatgatca tcctttatag aagctttaga ggaacgggga 2848141 tgccaccttg aatagtagtg gcatttttct ttaacacggc acgtcccgca aaaacgcccg 2848201 tcttcttccg gcaaggggtt ccactcactg tccggcccat agtaattcaa ggcgccataa 2848261 gcaaatacct cttccggatt ttgcccgagc caccaattga cgagatcgaa gtgatgtgtt 2848321 gatttatgga cagaaagacc gccggaaaac tgtctcgacc tgttccagcg tttaaaatag 2848381 ctggcgccat gatacgtatc aatataccaa tttaaatcaa cagaagtgac cctgcctatt 2848441 tttccgtcca gaatcatttc ttttattttc cgatgaaacg ggctgtagcg atagttaaac 2848501 gcgacggtga cttttccttc gcttttggcc tccgcttcaa gcacccgatt cgcatcctgc 2848561 actgttgtca ccattggttt ttcagtaatc acatctgtat tccactgaag gctttttaca 2848621 atatatgcga catgcgtatc gtccctgcct gccacaatga cgatatcagg ctttgagacg 2848681 cgcatcatct cgtcaaaagc atcttcgcta aactcaggca cgtgggccag ctcgggaaat 2848741 ttcttcttgc aaacggcaaa acgtttcgga tcggcatcca gcaatcccgt aatctcataa 2848801 tgagttgaaa accgctccat cagtggtttg ataaacatac tgaatgctct gctgctcaat 2848861 ccgcaaaaga cgatgttctt caatatcctc acctctatcg ggcttcagtt agttgagaaa 2848921 tcagctgcag cgcttcctct gttttttcag catacacagg gataaacgcc gccatatcgc 2848981 gattcaattg aaaagaatag ccgttcagct gttttttccc tttttcgatc tgaacggcat 2849041 agatcgtttt ttctcctgtt tttttattaa cagttgtata aggagatgtt ttttcaggag 2849101 gcaatccgtt taacggctga aaattttccg gatcatcgta agcttgaaac atgtcttcag 2849161 gcacgatgaa aacatctccc tcatgggcgg taatttcagt cagcagtttt tcctgaaaag 2849221 ctggaaagat atcgaccttc ccggcattct gctcggcggc cttttttatt ttttcctgta 2849281 cgccagcctg catatcagaa aagagaatga catgcattcc gtccggcctg cttgagcatg 2849341 atgccaaaaa gagcactgag acgatcacac acaaagccgt acgtatcctt tttgtcattt 2849401 ccccgctgac ctaaaaagag gctccagctc tgtcatagct aaaataaacg cgccggctcc 2849461 gtgcagatcg tttgtgcttc tttcgcggct gacataatag tcatagaaac cggctgacgt 2849521 tccgacacat atgtctttga cgagaaacgc tccgtcttct gatgtttcgg ttttatgctg 2849581 aatcaagcct tgatacgctt ttagcagtgt tgtttcgtaa gctctgtcta gatagccttt 2849641 attgattcct tttgcgattg cgtacatgta cagacaggat cctgagcttt ccagccagtt 2849701 atcagacctg tctcccttat caacgatctg gtaccataac cccgtctctt tgtcttgata 2849761 gcgacagatg cttttaatca tgtcctgcag cgtgtttttc cacacatgac ggttcggatg 2849821 cttcttcggc agctcttcaa tcatgtcagc aagagacatg acgtaccagc cgatggaacg 2849881 tgcccaaaat tccggtgaac agcctgtctc ttcattggcc caaggcattt ttttcgcttc 2849941 atcccaggcg tgataaaaaa gtccggtttt tgcatccttc gtatgctttc tcatcaatga 2850001 ctcctgaagc acaacctgat caaacagctc cgtctcctgc ttcagattgg catatttcag 2850061 tgcaaacggc ccccccatgt ataagccgtc aagccacatt tggtaaggat aaccgtcttt 2850121 gtgccaaaaa ccgccctcag acgtccggtt cagtgttcca tataagctgc gcagcctttt 2850181 tgccgctttg acataccgtt catccttcgt ctgctcgtat aatggaaaaa gaatgagacc 2850241 tgcttgaatg gcgtccagtt catctcttct aaataataga ttgccattat catcgattaa 2850301 gagatctgca taagccttcg catactcaaa ataccgcttt tccccggttg cttcccacag 2850361 ccgcaataca ccgcataaga aaacaccctg atggtagtgc cagcggtttg caggtggcag 2850421 ctcctcgact gtgtacgtgt tcataatggt gtttgccaat gcctccgcgt acgtaagagg 2850481 cgattttaca gcgattgatt gatccattga tcccatccct ttcctaataa attccttcct 2850541 cgccaaattt cttcgccaaa cgattcgcta gcatgaccaa aatcagcccg accgccgctt 2850601 taaatacgcc gactgctgta ctgtagctga attggccctg tttcagccct gcagtataaa 2850661 catacgtatc aaaaatttcc gccacttccc tgttagtcgc atttaacagc aaatacacat 2850721 gctcgaagcc aagctccagc gtgtctccga ttttcaaaat cagcaaaacg acgataacgc 2850781 ttttaatggc gggcagcgta atatgccaca tttgccgcag ccgtcccgct ccgtccattt 2850841 tcgccgcttc atacagctgg gggtcaaccg ctgtaatggc cgccagataa atgatcgtcg 2850901 accagcccgc ttccctccag ataacctgca gaatatacag gggccggaac cattcttcgt 2850961 tcagcagaaa attgattttt tcaccgccaa aaaacacaat cagttcatta atcaagcctc 2851021 cgtctaccgt taaaagcaca aacgaaagcg atacaacaat gacccaagac ataaaatgcg 2851081 ggatataaat cagcgtctga acaaattttt taaagagagc aatccgcact tcgttcaata 2851141 gaagcgccag cagtatcggc accgggaaaa atatggccag gttcaaagca aataacacga 2851201 gcgtgttttt taacaagaga aaaaatgtag gctcagtaaa cagcctgata aaatgcttca 2851261 gccccaccca ctcactgccc aaaatgccga ggaacggctg ataatcctga aacgcaatca 2851321 caattcccca catcgggaca tacttaaaaa gcaaaaaata aatacacccc ggcaaaatca 2851381 tcaagtacaa atatttttgt tgaatcagct tgattagtaa gcgctttctt ttttcttttt 2851441 taaaaatgac tgcatcaaca gccggcgctt gcgcttctgc tgttttcatt ttttcctagc 2851501 ctcctttcac ggattcttgc attcactgta gcgcagcagg caaaagtccg tctacaatca 2851561 tatgatcaca tcctgtttta tccctttata atcaagggtt cagccggtcc acctgaaaaa 2851621 aagacaccga tattagaaaa tgattattga caatatctat caatctttgg attaattgta 2851681 ttaaggtgaa gtggatgtta tgaaatgggg ggttttatga aaagaagcca atacaagttt 2851741 tactacaaac tgatcacgtt tttctgcctg ctcagcacca ttccggttat tttggtcgga 2851801 ttattttcgt acgagcactc tcagaaaacg gctatttcca acgtttcgga ggaaaaattc 2851861 gacacactcc agcagaccca gcaaagcatc gagcatatat tgaaaaccgt cgatcactct 2851921 ttaacccact atgtgagttc gccgcctctc cttcgcacat tgtccgagcc tttgcactca 2851981 gaccaatttc aaatctataa ccaagtgaac caagagctca attatctgca aagctttgat 2852041 accgatctgt ccaacatgac gttagtcagt tatacgaaaa aatggtacat gaacaattcc 2852101 ggtttgtacc gtttgaatac agacactctt catgaagcag cctcagcgta cacgaaacaa 2852161 aaagcgagcc gctcctattg gacgcttgag gaaaacaatc atttgatttc aaccaaagaa 2852221 ggcacagcag aaaactgccg ctacaatatc aatttaatta agcagcttcc tttgaacagc 2852281 acaaatacaa agggattggc cgccgcaagc atcccgagct gttcgcttgt caaaaatatg 2852341 cccggctatt caaacgccaa caacctgttt atcatcgatg aaaaaggcct catcatcctt 2852401 cataacaata tgtctgacgt tggtgaatct cttcataacg acggctttgt ccaaaaagtg 2852461 ctggcgcaaa cggccaatag cggacagttt gaaacagtga ttgaccggat tcattataaa 2852521 gtcacctatc aaaaatctga ctataatgca tggacttatt tttctctcgt ttccctgcct 2852581 gagttaaaaa aagaagccaa atcaatcggc tggatcactt ttgcagtatg cctcattttg 2852641 ttaacgcttt cattgctgtt ctcttggctt ggctcccgcc atttttacaa gccgatcagg 2852701 gtgctttacg aatcattcgc aagacatgga gccatacaag agaaacaaca gcctcctcaa 2852761 aatgaatttg agttaattga acagagcttt aagcagctga aggacagaaa tgacgacctt 2852821 gaagaaacga tgaagcagca ggccactcat ctgcagcaat attttatggt caggcttatg 2852881 cttggaaaac tgacggatga ggaggttgat aaccgttttg aaagcctcgg cttaaagcaa 2852941 aattggcggc accttgccct gcttgtgctc caaattgaca cactgaatca tacgccttat 2853001 gagaaaaaag atatggatct gcttttgttt gccgtcaaca gcctgattga gcgcaacatc 2853061 ccgacggaca aacatcttgc ccccgccgta gttgacaaac agcaggcgac gattttgatc 2853121 aatcaaagcg ggacaaagga agaattcatg gctgagctga atgagactgc aaggatgatt 2853181 caggaaaaag cggaagctga gctgcagctg tctgtcagca tcggcatcag ccagccgttt 2853241 gatgtgctga caaaagcgaa aacagcctat gcggaaggct cagaagcgtt gaaatatcgg 2853301 ctgaaagcgg aaaacaagtc gatcatcttt tacgaagacc ttgaccagaa aaaaaccttc 2853361 aaaacccatt ttccaaagca gcttcagcat gagctgttcg atgctgtcaa agcaggagac 2853421 aaggagaaag cggataaatg cctgcacgcg attttacaag ccattttcac ccagaacacc 2853481 aacccgtatc aatttcaaat cgccatcgcc cgttttttga accatgtgat tgagctgatg 2853541 catgtgcttg ggatcgaatt gtttgagctt gaagaaaaca aaatgctgta tgaccaaatt 2853601 tttgagctga aaacgttcga ggataccgaa aactggctaa agaatgagtt tattgatccg 2853661 atgacagaca aagtgaacgc ccgcgcggat gcccagtaca aaaatatttc cgacaacatc 2853721 attcatatca tccatcatga gtttgaatcc gaattgacac tggacgaaat cgcacgcagg 2853781 ctgcattaca acccaaatta tttaagcagt attttcaaaa aagaaatggg aatttcattc 2853841 agcgagtatg tctcaagcta ccgacaccat atggcgaaaa gctggcttgc cgaaaccgac 2853901 atggcggtca aggacattgc cgaaaagctg aaatataaaa actcccaaaa cttcatcaga 2853961 tcatttaaga agctggaagg gattacaccg ggaaactacc gccagcaaaa aagaagcatg 2854021 taaaaaaccc aaaaccgctt gcgcgttttg ggtttttcca atgttatttt gcttgtttaa 2854081 acgcttcttc gtattcctga ataatttgtt ttcctccgct tgactcccat ttttccactt 2854141 ctttatcgaa ctggctttct gtgatgtctc caatcatata tttgtaggtc gcgtcatcaa 2854201 tgattttctt cagttcgtca ccccgttccg actccgatgc ggaatacagg ctttcagccg 2854261 ggtttgagac gataatcttt tcattgtcct cggtcagctc ctcgtacgcc gtccgaagcg 2854321 gatctccagt gttttttaag taggctttat caatggcaat taaagcggac agcggctgaa 2854381 tatcagtctg ccagtctttt acctggcttt ctttgcgtgt aaacgttttg tcctcacctt 2854441 tgttgtaatg aacgccgtca atgccataag tcatcaggct atagacatct tcttcggcaa 2854501 ttcggtcaaa aaacgccaag atccgtttaa gctcagcttc cgttttcaca ctcgttttcg 2854561 ggaaagcaaa cacgccgtta tggcctcctg atgcccatac ccgctctttc ccatctgggc 2854621 cttttatgcg gttgatgatc tcgagcttca tcgatttatc agaggcatgg tcgcgcagat 2854681 tgaccgcatc taccatattg ccaatataaa ttccggcttt tccttgagaa aacagctctt 2854741 gctgctgggt tttgcttgtg acgggaaaat ccttattcat atacccgtta tcacgcagct 2854801 ttttcatata gttcatcgtg tctttgtatt cctgtgtcat gaaatcaggc gtgaatttgc 2854861 cgcccgattc cttccaatct gtcggcatgc cttcatacga gccaatcgtt ttaaacgcgc 2854921 cgtaaatcaa gtcattacgg tctgccagcc cgaatgtatc atctttccca tccttgtccg 2854981 ggtcgtcctc cgtaaatgct ttggccactt cataaagctc atccaacgtt ttcggggttt 2855041 tcaaatttaa attgtccagc cagtccttcc gaatgacgat cccctgtctg gaaagcgggc 2855101 gctctctgta tatcccgtag agcttgccgt caattgtcac atttttatta atgagtttgt 2855161 tcattttgtt taagttggga taatccttga tataatcgcc gatttcccaa aacattcctg 2855221 accgaaaggc attcatgact gacgaatttt taatatcctg gatggtcacg atttgcggaa 2855281 gattgccggc tgcaagcgct gcattcagcc tgtcttcttt caccgcgtct ggaacccagg 2855341 tgatgtcgag ttctgtattt gtcagctttt caatttcttt aatcgccctg tctttcggcg 2855401 gctgctggtg atacaaaatc gccatccaag acagctttac ctttgaatct gggccagctt 2855461 tgccttcagc cgaagactga tcagttcctt tacagcccgc cagcactccg ccgagtgcca 2855521 gtacaagcac aatcaaaagc accctccatt tgtttcccat cgtacccctc cgtttcatat 2855581 ttctttatcc tttgacagat cccagcaaag ctccttttgc aaaatgcttt tgtataaacg 2855641 gatagacaag cagaacaggg atggtcgcca ccactatgac cgccatttta atggtttgct 2855701 caggcggcgg gctgcccgac cccatttcag acatatcccc ctgcataccg cttgatacaa 2855761 tgacgatttg gcgcagaagc acctgaattg gccattttgc tgaatcattt aagtacaaga 2855821 tcgctgtcat atacgtgttc caatacgtga ccgcataaaa tagtgaaatc gttgcgatcg 2855881 caggaagaga cagcggcagc acaattttaa agaatatgcc cagatcattg cacccgtcaa 2855941 ttttcgcgga ctcttccagg cttgacggga tattttgaaa gaagtttttc agaatgatca 2856001 ggttaaaggc attaatggct gtcggcaaaa taagcgccca gtaagaatcg agcaatccaa 2856061 gcgatttgac cacaaggaaa gtcggaatca tgccgccgct aaacagcatc gtaaatacga 2856121 cgagaaacat gagcggctgc cggccgatta aatcacggcg ggataacccg taagccatca 2856181 gtgacgaaag aaacatgctg accgcagtgc ctatcactgt cacaaacaca gaaacaagca 2856241 aactcttata aataatatct gttgaaaaaa tgtagcgata agcatctagc gaaaaagtgg 2856301 tcggtattaa aataaatttt ttcgacacga cttcttctac tgtggcaaag gatgctgcga 2856361 taacatgaat gaacggaagt acgcatatta aagcgaacat cagcaagaaa ccataaatca 2856421 acatatcaaa cagacggttt ttcagtgaat gtgcgatagc tcccacctcc ctttgtaagc 2856481 gttatcatat ttttggaaac cgagctcagc atgtgacgat atcgtgtcta aaatgtagca 2856541 aatctgtgat tgccatgtct ataatcattt gaacagtgtc cccggccggg cgggggctgc 2856601 cgcgaattga gaccgataac aaaagaaaaa gagcataatc ttagaaaatg attatgctcc 2856661 gttctcctcc tcgttcagaa gttcagccgt attgatttgt ggcgaaaacc caagttcatt 2856721 cacggcagat tcaatggacc atggccggcc cggattatca gagacggcgt aataagtgcc 2856781 ataccggatg ttggtctcaa tggcggcttt gaaaatcgac agcagatcgg ggtgagaaag 2856841 cagtgtcttt ttcgtccgtt ctttttcatg cagcgtatcc atttcatctg tcacgactgt 2856901 tccgattcga aggttgatta ctgatagctt attttccaaa taaaacaaat ggccgatctg 2856961 ttcagaggtc agctttaata caccgtacaa gttttttgac agcggataat cgcttgttgt 2857021 gatttcccgt cctaagagcg agcgcccgtc tttttcatat acatctgtga catgattgct 2857081 gctggcgaac acgagctttt gaatgccgag ctccgctgcc gcacggcaca gataatagct 2857141 tgccctatag aaaacatccg tcattttttc aaactcagcg atgtccataa tatcgtattt 2857201 gattttcaca gcgagtaaat tcaagatggc atcggtatct tttggaatct tcttcaacag 2857261 ctcctcataa tttgccgcgt cagcctgaat ggaagaggct ttgccatcga aatgatcttt 2857321 atcaagcaca gtcacttcat agtctgaaat aagcccttca gcaagcagtc tcccaatcac 2857381 accatttccg ccggcgatca gcactttttt cacgatgttc actccccttt tttatagatt 2857441 gcccattttc ggcggggctg acactttttt ggcactcaca ttcttaggct tattcaaaag 2857501 tcaccggcag ctcctcaagc gcccgaaatc caaaaagcgg ccgataccgc cattcaaaat 2857561 ccgcaagatt aaggctgggc attcgctgca gaagagtgtt aatcgcaatt tgcgcttcta 2857621 atcgtgccag cgaggaccct aagcaaacat gatggccatg cccgaatgaa agatgcggat 2857681 taggacttct cgtaatatcg aagacatcgg ggttcgtgaa tatgctaggg tctcgattag 2857741 ccgctcctaa caaaagatag acttgttctc cttgacggat cgtcaccccg cagatgtcaa 2857801 tatcctctga cgcaactctg gctgtcattt gcgtggggct ttcatagcgt aaacattcct 2857861 cgactgcggt accaataaga tctggatttt ctctcagttt caaaagctgt tctggatgct 2857921 gcagcagaca aaggactgaa ttgctgatga gattgaccgt tgtctcatgt ccggcgatcg 2857981 ccagcaatat gcacgtagat gccgcctcct cttccgtcag cttatccttt tctctcccct 2858041 tcaagagcat gctgatcata tcctgttgag ggtggcgttt tctcttttga atcagctctt 2858101 tgaaatatgc catagcctgc acagccataa tattgccctc tgttaatgcc tttcttgagc 2858161 gggtaaaatc aatcgtttga atgagactcg cagcccactc ctttaattgc tccctatctt 2858221 cctccggtac acctataatg ttagctatga caaaacttgc taaaggaaaa gcaaagtccg 2858281 aaatgacctc catctttttt ttaccttgca cttgatcaag caaatgatgg acagtttcaa 2858341 tgatatacgg ctgataactc tctgtcgttc tcggcgtaaa cgctccgctg gcaagcgtcc 2858401 gcaatcgtct atgatcaggc tggttctgaa acagcatcat ttgattttgc acatgtgaaa 2858461 ggtcctgata tttggttgag ctctcaggca gcggggtgcg gactttgaat ctcgcatctt 2858521 tcaaaatagc agccgtttct tcatatcctg tgacatacca gcccgggtat tttaagaaac 2858581 tccctttata gataggatga acagctcgca atgtgtcgta aaaagaatat gggtttttca 2858641 aaaactcaga agatgcagtt gacgatgcaa ttgtcacgtg attttctcct ttctgttcaa 2858701 aaataaaaac aatcgacatc ataccgattg cttttattga ttctttcagc ttttcgcact 2858761 taaactagcc ttcatttctt cgactgattc aacttcaaag cctaaatcac tcagcatttt 2858821 atgatcctcc gtctcctctt gcccggcagt tgttaagtag tctccgacaa aaatggagtt 2858881 tgcggcgtaa agccctaatg gctgcaatgt gcggagattg acctctcttc ctccggaaat 2858941 gcgaatttct tttgatggat tgataaaacg gaacagcgcc agcactttta aacaatacag 2859001 cgggtttaat tcgttgacgc cttctaacgg cgtgccatca attgcatgca aaaaattcac 2859061 aggaatggaa tccgcgtcaa gagccttcaa gcttttggcg atgtcaatga catcctgttt 2859121 cgtctccttc atcccgataa tggcgcctga acacggagac agccccgatt cttttgcgat 2859181 ttcaaccgta ttgactctgt catcgtatgt atgtgaggtt gtgatgtttg aatggtttct 2859241 ctgtgacgta ttcaaattat gattatagcg gtctactcct gcatctttga gccgcttcgc 2859301 ctgctctggc ttcaacagtc caagacatgc acaaatcttc agtccatacg tctctttaat 2859361 ttcctgaacc gcatctacga cctgatccac ttctctgtta gacggacctc tgccgcttgc 2859421 cacgatacaa tatgtgccga tattcagatc gtgcgcccgc ttcgcgcctt caagcagcgt 2859481 ttccttattc accatccggt aagactcaat cggcgctttc gaaatcgcag actgtgaaca 2859541 atagccgcag ttttccgggc agagcccgga tttcgcattc ataatcatat tgagctttac 2859601 tttttttccg taaaagtgtt ttctgatgtg aaaagccccg tgcattaata gcaaaatatc 2859661 ttcatcagga caatgtaata ttgaaagcgc ctcttcgtca gtcacttctg ctccagccag 2859721 cacccggtct gcgagttcca tccattgatt cattctcata cccccacttg attcatcagt 2859781 aatgatagat tgatatggtc ttttaccata tgtagaaccg tttctttcgt cacgttggca 2859841 agctttggcg taacccctaa aatcggcaca ccgcataagc gctcaatcat ctcaggattg 2859901 gttttttcat cttcatcagg agagtcactg attccattga tgataattcc ggcgattgga 2859961 agccccatgc tttctgcata tttgacagtt aaaaaggtat gattaatggt tccaaggcga 2860021 ggacgcgcca caataatcat gggaagctgc aacgctttta tgacatgact gaccaaatag 2860081 tcctctccca atggcacaga aataccgcct gcaccttcta cgatgaagca ttcatgtttt 2860141 tctctaatcc gcccccaatg gcttaaaacc tcttccatgg tgacagtctt tccctcaagt 2860201 ttccctgcaa cgtatggtgc aagcggcgcc ttgaaggcaa aaggcgtaat gtcttcatga 2860261 gaaagactgg tctgcgacat atctttcagc aaacttgtat cactatctgg atgatggcgc 2860321 gatatcccgc ttaaaaatgg tttatacacc ccgacatgtc tattattgtc tttcaataag 2860381 gcagcaagac cgctggatat aaccgttttc cctacttctg tatcagttcc cgtcacaaaa 2860441 aaacccctca aatgatgtgc agctcctttc cgattgaatg aaatgtttgc agcaaatgat 2860501 caatatcacc catactgtgg tcagacgtga ttgtaattcg aatccggctt tcacccggcg 2860561 caacggttgg cggccgaatg gcaggagcat aaattccctt gccctgcagt ttttcagcaa 2860621 ataggaccgt tttatgggca tcgccaatga ctacaggaat aatcggtgtg tgatctcctt 2860681 tcaccacata acccatattc ttcagactgg ttctgatcat gctgatataa gaaaataaaa 2860741 gctgtcgttt ttccctgctg gcttcaatga tgttgaaagc ctcgtgagca gccgcacagc 2860801 tggctggcgg aatagcggtt tgaaagataa atgttctggc atggttcagc aaaaagtcga 2860861 tgaagaccgc tgatcctgcc gcaaaacctc cttccgcgcc aacagctttg cttaaggtgc 2860921 cgataacaat gtcgggacaa acaccaaagt attcactcgt tccttgtccc gaatcgccca 2860981 aaactcctgt tgcgtgggca tcatcaacga ccacgaaggc atgatagcgt ttcgcaagtg 2861041 agatgatctg atcaagaggg gcgattgtgc catccatgct gaatactccg tctgttacga 2861101 taaaacggcg ctgataacgc tgtgtttcat tcagcttgtt ttcaagatca ttcatatcaa 2861161 tatgccgata aacaactgta tcagccttag aaagtcggca gccgtcgatc atacttgcat 2861221 gattgagctg gtcacttaaa atgacatctt ccttttctgg caaggatgaa aggacaccga 2861281 cattggccaa gtaaccgctc gaaaacagca gggccgcttc tgtcagttta aagctggcaa 2861341 tcttcttttc tagcttttca tgccagaccg aattgcctgt cgttaaacgt gaaccgctgc 2861401 ttcctgtccc aaattgctgc aatgctgttt gggctgcatc gatcaaacgt ctatcgcttg 2861461 cgagccctaa ataattgttt gaggaccaga ccgtttgatt ttcgccatca atattcctct 2861521 ctggaaccgg cgctccatcc attgaccgca ggttacgatg tacgccggct tctttcattc 2861581 tgtctaaccg ctcgtttaac caggaatcaa tcttcaaggc tcgtaacctc gtggatcgct 2861641 tgtttcataa tggcaaccat ttccgagagc tcttcagctg tgctggcaag aggaggaaga 2861701 aatgcaatca cgtccccaag cggtcttgtc agcattccta actctctcat ttttaaggaa 2861761 actttgtatc caatccgccg atcagccggg taaggttctt tagtttcctt tgatcgtaca 2861821 agctctgcac cgcacataaa gccaagctgc cgaatatccc caacatgagg aagagcgtgc 2861881 agatcttgaa gaagaaaatg gagcttttta cttttttccg ctacttgttc cacaatgttt 2861941 tcagattcaa ataatgccag attttcaagc gcaaccgcac agccaagctg attgcctgta 2862001 taggaatggc catggaaaaa ggtttttagg ttttcataat catcatagaa tgccttatag 2862061 atgtcttcag tggcaaacgt aacggcaatt ggcaaatagc ctcctgtaat gcctttaccg 2862121 gcagccatca gatcaggctg gacattctcg tgctcgcacg caaacatttt tcctgtacgg 2862181 ccaaagcctg tagcgacttc atcaacgatc attaagacat cgtatgttgt acatagctcg 2862241 cgcacgcctg ccaaatatcc ttccggcatc acgatcatac cggacgcgcc ttgtaccatt 2862301 gattcaatgg aaagcgcggc aatttcctca tgatgttcct caagcagctg tgcaagctct 2862361 cggaggcact gatcacggca ctcatcagga tcaccgcttt cagaacgata cacataagga 2862421 atcggggcct tgtaactctc gaacatcaac gggccgtata cgtggtgaaa aagctcaatt 2862481 gaaccgacac tgacggcgcc aatcgtatca ccgtgatacc cgtttttcat tgcgatgaat 2862541 ttttgtttct cgggcttccc gatgttcttc caatactgaa acgccatttt tagggctatt 2862601 tccatcgcct ctgcgccgct gtctgaataa aagacccgcg tgagcttttt tgggctgatg 2862661 tcgattaatg tttcggcaag ctgggttgct ggaacattgg tcatgcccaa taacgtggag 2862721 tgcgcaattt ttccgagctg tttttttatg gcgtcatcta gttctttttt gcggtgtccg 2862781 tggacattaa gccaaaccga tgaaaaaccg tcatagtatt ccttgccgtt tatgtctttg 2862841 actttgattc cagtcccgct ttcgatgatt aaggggtttt catcataatc tttcatttgg 2862901 gtaaatggca gccagaggtg ctttttactt ttttctatca aatcatgagt catgatcttc 2862961 ctcccactct attaaaatag gctgcttctc caggtcatgt atgtacgtgt ttacatcatt 2863021 ggatccatca ataaaaaaga ctcggcagcc ctcttcagtc ccgtattctt tcattgctgt 2863081 aatacgctga tagcccattt tcttacccgc aacatagcct gttatgtaat ccggatcgtc 2863141 cgaccagcat aattctgcaa cgactgccgg gtgccggctt acctttgaag cgagcgcaag 2863201 ggcctctttt attcttgaat gagctggcac gtgactgtga agcgcccatt tttcaaaatt 2863261 agcgtccggc caatccattc tggagacccg cacccctttt tcttttgttt gatccattcg 2863321 cttgcctgta tgaatatcaa acaacaccgc acccctgaca tctgaccatt cagggatttg 2863381 ttcatatgct ttttcaatca cgtctcgtga aacgccttct ttttccaata acaatcgggc 2863441 aagcttttgt ccttcttccg ggcagctcac ttcattcgta tgcacaggca atggctgaat 2863501 ggtttttatc gattcatgta cctcttcaaa ttgaatttgc ataaaatcag gttttcctct 2863561 tgaatgggat aacccttttt ctaataaagc attgactgta tgcttcatct catggaaagg 2863621 aataagccgt tctccgccgg atatatgctt tccgccgtct tcatgagatc cattcattga 2863681 agccctcatt ctgacactat aaaaagtttc ttcttgcatc atttctcgcc ctttcactga 2863741 taactgaaga acgtgtagcg cttctcacct aaattgttaa ccaattatat tcaaaggtta 2863801 acaattagaa tatattattc tctcctgttt ctgtcaatag aagaaaggat cgatttatgg 2863861 cagttggtta aaaggaaaca aaaagaccgt tttcacacaa aacggtcttt ttcgatttct 2863921 ttttacagtc acagccactt ttgcaaaaac cggacagctt catgccttat aactgctgtt 2863981 tcgaaatgtc ccgaagcaga acggaccact cggtagcaat cagcagctcc ctgtccagca 2864041 tagacagctg tcaattcttt ttcgattttg tccacgccct cagccggcgt taaccgatcg 2864101 tgtacaccaa caagactaag gtgcgggcgc ggcgcgatca ggctttggat ctccgatgcg 2864161 gaaaaatgct ttgcaagcga tgggacgtaa taataaaagc cgtgcctgtc aagattctgt 2864221 gttttgatca gcacgtgatg atccacctgg ctgcacaaat ccacacacac cttaatccgg 2864281 tcatcgagcg ccgctgtcca ccacgccatc aaacctccca tagacatgcc gatggttccg 2864341 atcctgtcag gctgaacatc agagcgtgac tgcatatagt ctaacgcact taaactgtca 2864401 taaatcatca tcccccacat cacttttccg gtgagaagca tttctttaaa tatctcgctt 2864461 tccgcttttc cccgccgatc tccaaacccc caatgatcaa tcgcaagaac gccgtatccg 2864521 agtgaagtaa gctcatcaga aaaagaaggc gttttcaaat aatccgctcc ctcaatcagc 2864581 tcactttttc ccctatcata ctggcctcca tgcgaatgct gaaacaatac ggctgggcac 2864641 ggtccttctg ttttcttcgg cttcacaaaa taagcgggcg ccttttcatg tccatttaaa 2864701 tcgagcagga gcgtttcaac gatattttct tctctttctt caatacgtaa tgtctcaaca 2864761 ctgattggcc tccgatcagg caaatcacca agcaatcgaa acagttgctt tcttctttcg 2864821 gctctcatcc catcaccctt ccttattcgc ttacttcaca tttacgagac agatctgggt 2864881 tcccctttat ttttccaaca taaatcacat catttactaa atatttagta aatattatgg 2864941 aatatttcga aaacaattat tgtaaccgct tacttttata tgataatatc aatttatcaa 2865001 aaacagatga gttaatattt tactaaatag atgagaggga tacccatggt tcgtattaaa 2865061 gatatcgcct tgaaagctaa agtttccagc gcaactgtgt ccagaatttt aaatgaagat 2865121 gagtcgcttt ctgttgcggg cgaaacgaga caaagagtca tcaacatcgc tgaagagctt 2865181 ggttatcaaa ccgttgccaa acgccgaaaa tcccgcgggc aaaaacagcg ggctcagccg 2865241 ctgatcggtg tgctgagctg tctgtcccct gatcaggaaa ggcaggaccc ttatttttct 2865301 tccattcgga aagggattga aaaggaatgc tttgaacagg aaattttcat tacaaattcg 2865361 attcatctcg gctcctttca ggaacatatc tttcgggaat tggatggtgt cattgtcatc 2865421 ggccgtgttc atgatgaagc ggttaagcat atcagcggga ggctggagca tgccgtattt 2865481 atcaatcatt caccagatcc gcaagcatac gattcgattg gcatcgattt tgaatcggct 2865541 tcacgccagg cgattgatca ccttttcgac ttaggctaca aacggttagg ctacattggc 2865601 ggacaagaaa aagagcatac gctgaaggac ggccaaagca ttcgcagaac gattgaagat 2865661 aaacgcctga ccgctttttt ggagtcagcc gccccccagc ctgagcatgt gctgatcgga 2865721 gaatacagca tgcgtgaggg ctatcgcctg atgaagaaag caatcgatca aggccatctg 2865781 ccggaagcat tctttattgc cagcgattct atggcgatcg gcgcattaaa agcgctgcag 2865841 gaagccggac tgcaagtgcc gcgggatacc gcaatcgtca gctttaacgg cattgaggaa 2865901 gctgaatttg ccagcacgcc tttaacgacg gtgaaggtat acacagagga aatgggccgg 2865961 acaggcgtaa aactgctgct tgaccgtctc aatggccgaa cgcttcctca acatgtcacc 2866021 ctgcctacaa cattaatcgt aagacaaagc tgcggatgta cagcaaagga ggtgacataa 2866081 gcaaagattc atcacgatga taaggaggaa aagatgaaac acacttttgt tttatttctc 2866141 tctcttattc tgcttgttct gcccgggtgt tcagcagaga aaagctcagc agataccgca 2866201 aaaaagacgt taaccattta ttctacaatg tcaaccgaca gtgaaagaga tacgttcaga 2866261 aaactagcgg cagcattcga aaaggaacac agtgacattc atgtcagcct tcatttccca 2866321 ggcaatgact atgaaaatat gatgcgtgtc agaatggcgg ccaatgattt gccagatcta 2866381 ttcgatacac atggctgggg gaaaatcagg tacggagaat atacagcgga tctccgggat 2866441 atgaaatgga ctcaagatct tgatcccaat ttaaacagca tcctcaaaaa taaaagcgga 2866501 aaggtgtatg cctatccaat caatcaggca aaagacggtc tggcgtataa tcgcaatatt 2866561 ttagaccgtt acggcattgc tccgccggaa accatggatg actttatcaa agcactgaga 2866621 acgattaaag aaaagagcaa gggaagcatt gttcccttct ggtttgccgg atatgacaaa 2866681 agctcattcg cccaatatta cgaccaattc gctacacctc ttctcatcac agaccctgcc 2866741 cataatgaaa aaaaacagct catcaacggc acttttcaat ggagtaaatt cacttattta 2866801 tcagaaatcc tcaaacaaat gcagaaagaa aaattgatca atatcgacgc cgtcacggca 2866861 aaaaaatcac agctcattga attaatggcc caaaacaaaa tcgcctttac aatgcaaggc 2866921 ggcacactcg gccaagacgt tgcccagatc aacccgaacg tcaaggtcgg cattatcccg 2866981 acacctgcca tccatcccgg tgatgacccg atatggatcg gcggtgaacg ctacaccctt 2867041 gcagcatgga aagattcgcc tcaattaaaa gaggcaaaag attttatcgc atttatggcc 2867101 cgcccggcca atgccaaaca aatggctgaa gccacatcgc ttccttcagg gctgaccaat 2867161 gtgaaagctg atattttcta cgcaaacgat tatgagtatt atcaagatgt caaagtcgag 2867221 ccttacttcg accggttata cttgccaaac ggaatgtggg atgtcctggg cacggttggg 2867281 caggagctcg cggctgacat tttggcgcct caagacattt cgcagaagct gggaagagaa 2867341 tataaacgac tccgggagca atccgaaaca cagggagctg aaaacaatga gtgagatcgc 2867401 aagggacgtt catgtgaaac aggttaagcc aaaaaagcag tcctcacttt ggtggatgta 2867461 cattcctgct ttgctctccg ttctggtctt tatgatttac ccgtttgtga aaggcacatt 2867521 gattaccttt acaaactgga acggattttc acaagtctac caatgggttg gattcgcgca 2867581 atatgaaagg ctgttttctg atcctgatac ttggcatatc ttaaaaaaca cgctgcatta 2867641 cgggcttggc agcacctttt ttcaaaatgt ggtcgggctt ctgtacgctc tcctcttaaa 2867701 tcaaagcatt aaaacgaaag cggtaacaag aacaattgtg tatttgccgg tgatgatcag 2867761 cccgctcatt atgggctaca tttggtactt tttcttctcc tatgacggag gcgcgctcaa 2867821 cgatttgctc ggggtcttcg gcatcagccc tattaatgcg ctcgccagtc cctcgctcaa 2867881 tccatggatc attgtcatga ttaacaccta tcaatatgtc gggatcgcta tggttgtcta 2867941 cttagccggt ctgcaaagca ttccgaaaga ctactatgaa gcggcgcaaa tggatggcgc 2868001 gaaacaaggc cagcagtttt ttaccatcac gctgccgctg ttaatgccct ccattaccat 2868061 taatatagtc atcaacatta tcggaggctt aaagctgttt gacgtcatca ttgcactcac 2868121 cgcaggcggc cccggaaatg cgtcacaatc catgtccacg tttatgtatg atttgtattt 2868181 caaacggcag gatgccggct atgccgcaac gcaaggcata tttatggcat ttgtcatttt 2868241 gatcatcagc ttttgcgcgc ttgcgtactt taaaagaaag gagacggaaa tgtcatgaga 2868301 gccgcccgta caaaaagcat gcggatcatt acgcttcttg cagccattgt ggcctgtgcg 2868361 cattttattc ctttttatat cctgctgacc acttcattga aagcaaaagg agactacagt 2868421 tcgaaatgga tatttccagc cgacatctcc tttcataatt tttcagaggc gtgggagcgc 2868481 gcttcgctag gaaactcttt tataaacacc atgatcatca caggtttttc tgccttgtta 2868541 ttaattatat tcggctcact tgccgcctac ccgcttgccc ggcgggaaac gaaactgaat 2868601 aaagccgttt ttgccttgct gatttccatt atgatcatcc ctccgttaac gtccatggtt 2868661 cctttgtacc gaatggtcgt ggacgccgga atggtcaata cacacgcaat cgccattttc 2868721 atcaatacag cggcttacat gccgttaacc gtattcttat attcaggctt tatccgatcg 2868781 accattccaa aagagcttgt agaagccgca agaattgacg gtgcaggcat gctgaaaatc 2868841 ttttttacga ttgtgtttcc tctgctgaag ccgatcactg cgaccatctg tatcatttct 2868901 tgtgtcttta tttggaacga ctatcaattt gccattttct ttttacaaga tcaaaaggtt 2868961 cagacattaa cagtagccat ggcaggtttt ttcggagaaa acgcaaacaa ccttcattta 2869021 gttgccgcag cggcacttat ggcaatgctg ccgatggttg ttctgttttt ggcgctgcaa 2869081 aaatacttta ttgccggcct gtcttccgga gcggtaaagg gttaacatta aagggggaag 2869141 caatatgaaa aagattacat ttatcggtgc agggagcacg attttcgcca aaaatgtttt 2869201 gggagactgc ctgttaacag aggcactgaa tggatttgag ttcgctcttt acgacattga 2869261 tcccaaacgc ctgcaggaat cccagctcat gctcgaaaat ctaagagacc gttataaccc 2869321 aagtgtggcc atcaacagct atgatgacag aaaactcgcc ttgcaaaacg caggctatgt 2869381 catcaatgcg attcaggttg gaggatacaa accgagcaca gtcatcgatt tcgagattcc 2869441 taaacggtat gggctgcgcc agacgatcgc cgatacagta ggcatcggcg ggatattcag 2869501 atctctcaga acaatcccgg tcttatttga tatcgcaaaa gatatggagg aaatgtgccc 2869561 tgacgcatgg ttcttaaact atacaaatcc aatggccact cttacaggcg ccatgctccg 2869621 ctataccaat atcaaaacaa tcgggctctg ccacagtgtt caagtgtgca cgaaggattt 2869681 atttaaagct ctcggaatgg agcatgacgg aattgaggaa cgcattgcgg gcattaatca 2869741 tatggcttgg cttttggaag tcaaaaaaga cggcacagat ttatatccag aaatcaaaag 2869801 gagagcgaaa gaaaaacaaa aaacaaagca tcatgatatg gtgcggtttg aattaatgga 2869861 taagttcggc tattatgtca cggaatcgtc cgaacataac gcagagtatc acccgtactt 2869921 tattaaacgg aattaccctg aactgatcag cgagctgcaa atcccgctcg acgaatatcc 2869981 gagaaggtgc gtcaagcaga ttgaaaattg ggagaaaatg cgggatgata tcgtcaataa 2870041 taaaaacctt acgcacgaac gctcaaagga atatggttca agaattatag aagcaatgga 2870101 aacaaacgaa ccattcacct tcggaggaaa cgtcttgaat acagggctga tcaccaacct 2870161 tccttcaaaa gcggttgtgg aagtgacatg cgtcgccgac agaaaaaaaa ttacaccgtg 2870221 cttcgccgga gaactgcctg agcagcttgc agccttaaac cggacgaata ttaatacaca 2870281 gctgatgaca atcgaagcgg ctgtcacacg aaaaaaagaa gcggtttacc aagctgcaat 2870341 gcttgatccg catacaagcg cggagctttc catgaaggac atcatctcca tgtgcgacga 2870401 tttatttgca gcacacggcg attggcttcc ggaatacaaa taaaaactag gggaccgctc 2870461 tcccctagtt ttttggtttt gtttcgcctt cccaggccat catgccgcct tcaacattga 2870521 ctgttttaaa gccttgctca tccaggtact tgcagacgtt catgctgcgc attcctgagc 2870581 ggcagataaa tacgtactct ttgtctttat caagggtttc cattttttca ggaatatccc 2870641 ccatgcgaat atgaacggct tgcgggatca tgccttccgc tacctcttca tcttctctga 2870701 catcaattaa atataattct tcgtccgcct caattttttc tttcaaagcg gctgtgctga 2870761 tttcttttat ttccaaagaa aacactccta ttcacagtga tcatgttcag tatatcaaag 2870821 tcagccgaac gattgctatt ctgagactga tgaaaaaaaa tccccttttg gcaaagggga 2870881 ttttttctag gcttagtttg ccacaatatt gacaagcttc ccaggcaccg cgatgatttt 2870941 ccgaatcgtt ttgccttcaa gctgctcttt gaccttttca tctgcttgag caagctgttc 2871001 cagctgttct ttcgttgcat cggcaggaac ctgtaatttc gcttttactt ttccgttcag 2871061 ctgaacaacg atttcaactt catcatccac aagttttgtt tcatcatata caggccaagc 2871121 ttcgtaggca attgtgccgg aatggccaag cttctcccat agctcttccg ctaagtgtgg 2871181 cgcgacagga gaaagaagct tcacgaagcc ttccatatat tctttcggca gttctgttgc 2871241 tttataagct tcattaataa agaccatcag ctgggaaata cccgtgttga aacgaaggcc 2871301 ttcataatgg tctgtgactt tcatgaccgt ttcatgatag acgcgctcca atgtttcacc 2871361 cgcgccttca acgatttttc cattaagctc accgctgtct tcaataaata ggcgccatac 2871421 acggtcaagg aaacggcgcg caccgtctaa tcctgattca gaccaggcga ttgaagcatc 2871481 aagaggtccc atgaacattt cgtacaatct cagcgtatca gcaccgtgag aggccacgat 2871541 ttcgtcagga ttgacaacgt tccctttaga tttactcatt ttttcgttgt tttcgccgag 2871601 aatcattcct tggttgtaca gcttttggaa cggttctttc gtcggcacta cgccgatatc 2871661 ataaaggaac ttatgccaga agcgggcata cagaaggtga agcacggcat gttctgcacc 2871721 gccgatatac atatcgaccg gaagccattt ttccaatttt tctggtgatg ccagctgatc 2871781 cggattgtgc ggatcaatat agcgcaagaa ataccagcag cttcccgccc attgcggcat 2871841 tgtattcgtt tctcttcttc cttttttccc tgtctcaggg tctgtgactt ccacccactc 2871901 tttaatgttc gcaagcggtg attcgcccgt tccgctcggt ttgatttcat ccgtttttgg 2871961 caaaatcagc ggcagctcct cttccgggac agctgttgac gttccgtctt cccaatgaat 2872021 gaccggaatc ggctcgcccc aataacgctg gcggctgaag agccagtcac gaagacggta 2872081 cgtcactttc ttctcaccgt ttttcgtttc ttccagccaa gcgatcactt tttcaatcgc 2872141 ttcctgtttg tgaaggccgt tcaggaaatc agagttcacg tgctcgccgt cgccagtata 2872201 ggctgcttcc tcaacgttcc cgccttttac gacttccttc accggaaggc cgaatgtttt 2872261 ggcgaattca aaatcacgct catcgtgtcc tggaactgcc atgacagcac ctgttccgta 2872321 tgatgcaaga acataatccg caatccaaat cggcagtttt tctccgttta caggattgat 2872381 cgcatacgct cctgtaaata cgcctgtctt tgttttcgca agatctgtgc gttctaggtc 2872441 actctttgat tgaatttctt tgatataagc ttcaacagct tctttttgct ctgccgttgt 2872501 gatgttttcc accaatgcgt gttccggggc aaggacagtg tatgtagcgc caaacagcgt 2872561 atctggtctt gttgtaaaca ctgtaaagga atcatcatgt ccatctatag caaaatgaac 2872621 gtgagcgcct tccgaacggc cgatccagtt gcgctgcata tctttaatgc tttccggcca 2872681 atcaagctct tccaagtcct caaggagcct gtccgcataa gcggtgattt tcagcatcca 2872741 ctgcttcatt gggcgtctct ctaccggatg gccgccgcgt tcgctcttgc cgtcaatgac 2872801 ttcttcgttg gcaagaacag taccgagcgc agggcaccag tttacaggca cttcgtcaac 2872861 gtaagcaagg cctttttcgt atagctttaa gaaaatccat tgcgtccatt tatagtattc 2872921 agggtcagtc gtattgattt cgcgatccca gtcatatgag aagccaagcg cttgaatttg 2872981 gcggcggaag ttatcaatat tctgcttcgt aaacacagcg gggtcgttcc ctgtgtcaag 2873041 cgcgtactgt tcagctggca ggccgaatgc gtcccagccc attggatgaa ggacatcata 2873101 gccctgcatg cgcttcatgc gggacagaat atccgtagct gtgtatcctt caggatggcc 2873161 gacgtgcaac ccagctccag acggataagg aaacatgtcc agcgcgtaaa atttttgttt 2873221 ttcattatta tcaagagtgg caaatgtttt gttttcaagc caatatgtct gccatttctt 2873281 ttctatctct ttgtgctgaa aactcaaagt aaaaacctcc ttctgattga atacggcgtg 2873341 tatggttcaa gtattgacgg gaaggagagg attatattca gaatattccc aaactaaaaa 2873401 aaactccctc atcccaaaaa gggacgagag actttcgttt tcccgcggta ccaccctcgt 2873461 tagcgcggca tacgccgcac tcacttgata cttttaacgc agttatgcgt cagcggcttt 2873521 tcaccgctgc aactctgagg tgagttcgga aacaaacttg attgactttc accagccgtc 2873581 aactctctgc aacaatatct gtttcttact gctcctcttc attgttctta tcgcaaccgt 2873641 aatctaactg tattttatag aattctgttc ataagtgcaa gcaggtttgt atacaatggg 2873701 aatgtaccct gaacgggcgg agattgagga caattattcg ggtggagttt tggtttgacg 2873761 tttggactcg gccggttcgc cgccgctgtt cagttctctc acaaagtcaa aacttctgag 2873821 aacagcttca ccgccgtagc ctgagataat ggataagatg acaagttgaa ttcctgaatc 2873881 ggggtcagcg gataatacaa gtaaaatgga agccgtcatg ccgataaacc aatcttccaa 2873941 aaatccaagg tagataaacc gcttcgtcat tctgggcttc tccagcctgc ctctcttttt 2874001 cacatgaccg agaatcccca tgattcctcc aattacacaa gcaatgagta cctgatgcag 2874061 catcttcatc atcaccttcc taaagccctt atttcgtaaa gcgacttcag gccatccagc 2874121 ccccttaaac gattccgatg attttcgata tctacatacc ggcaaatctg taaaaagctt 2874181 gtttcttcca ttatatgtga acacatgatc ggtaagcttg atgcattgga ttcatttttc 2874241 acccagtgac attgacctag tcacctattt agcatgtaga aaacctttcc gttcatatgt 2874301 tcaaattctg ttcttatttt tagtgtatac gaggacaagc cctaatgaca aacaacaaac 2874361 tgcacttgct tgaatcagaa catgtgttgt gctacggtta ctgtagaatt catttttaaa 2874421 aaggggaata tcaggctttc gcatagcaag ctgacggcct aagggggatt tatatggcta 2874481 gttttcaatc atttgggata ccaggacagc tggaagtcat caaaaaagca cttgatcacg 2874541 tgcgagtcgg tgtggtaatt acagatcccg cacttgaaga taatcctatt gtctacgtaa 2874601 atcaaggctt tgttcaaatg accggctacg agaccgagga aattttagga aagaactgtc 2874661 gcttcttaca ggggaaacac acagatcctg cagaagtgga caacatcaga accgctttac 2874721 aaaataaaga accggtcacc gttcagatcc aaaactacaa aaaagacgga acgatgttct 2874781 ggaatgaatt aaatattgat ccaatggaaa tagaggataa aacgtatttt gtcggaattc 2874841 agaatgatat caccaagcaa aaagaatatg aaaagcttct cgaggattcc ctcacggaaa 2874901 ttactgcact ttcaactcct attgtcccga ttcgcaatgg catttcggct cttccgctag 2874961 tcggaaacct gacagaggag cgatttaatt ccatcgtttg cacattgacg aatatcttat 2875021 caacatccaa agatgattat ttgatcattg atttatccgg attggcccaa gtgaacgaac 2875081 aaacggccga ccaaattttc aagctgagcc atttgctgaa attgaccgga actgagttaa 2875141 tcattactgg cattaagcct gaattggcta tgaaaatgaa taaactggat gccaattttt 2875201 cgtcgctgaa aacatattca aatgtaaagg atgccgttaa agtgcttccg attatgtaaa 2875261 aagatcccgc tcacccagct ggatctttca gattgttgac aaaatcctaa aatggttttc 2875321 attttaggat tttgtcatct tttcagcgtg attgaaaacc cttgaagtct aggaaggacg 2875381 agcataggag cggagcgaat gttctaattc gtgagcaccg aagcgcaggc ctgacaacga 2875441 atgcgagggt ttgtcgacac gctgaaagat cccgctcatt cggcgggatc ttttattatg 2875501 aagagattga tgcctgctta tttgtttctt tagctgattt tatccgtttg tcatatagaa 2875561 gcgttgtggc aatactgatc agcagcaata ccaacagaga taaaacaaga gccctaatgc 2875621 cgtaatgatc gacaagcact cctccgaaca ggggaccaat cattctgccg cctgtcgccg 2875681 cactgttgac aaagccttga taaaagcctt ctttcccttt aggggcaagc tgattggcaa 2875741 tagtcggcac agcaggccaa acaagcattt ctccgatagt caggatcacc atcgcagcga 2875801 gaaacatcgg aaattgcttt gcagtcagca gcatgctgaa agacacaata aaaatgataa 2875861 agccgatgac catttgcgct tttagcgact cggcccattt tttcaccaca aaactgacga 2875921 gcggctggcc gagcacaatg agaattccgt taaccgtcca cagcacgctg tataaggaaa 2875981 gagatattcc aatgctttgt gtgtacgaag caattgtggt tgaccactga gaataagcca 2876041 gccatccgag tacatagcct ccgcttaaaa tgatcagtgc ggcaaatttt gctttgctgt 2876101 tcacagcatc ataatcaagc acggatgttt gggatgcatc gcccgtttga atatttcgaa 2876161 atccgaaata tacaataaag aaaaagatca gatacaatac ggcatttgcc aaaaatacat 2876221 atgaaaacga gaaagatgcc acgacaccgc caagcgctga accaacggcc acgcccgcgt 2876281 tttgcgcgac atatatcgca ttaaatgcct tccttccccc ttcaggccat accgatcccg 2876341 ccattgcgta gcttgccgga aaaacaacac cggagccaaa gcccacaatc gtcagcagca 2876401 caatataggc tggccaatca tgaaaaaaga caagacccat caggcttgct aacgtaatgg 2876461 ctatcccaag cataatcgat ttaaaaccgc cgattttatc aaacaaaaaa cctccgcata 2876521 aattgccagc cacactggcg ccggaattca gcatcaggac aagtccggct actgttaacg 2876581 actttcctaa atgattatgg atataaatcg tattcagcgg ccataaaaaa gaagcacccg 2876641 tcacattgat aaacattcca atgactaaaa ttttaagagc acgcggcata ctcatccccc 2876701 tttcttacct aaaaaagctc atgaaaaaaa cgaaacctaa aacggctccg tacgaatcca 2876761 gttatcatag cacattcatt ctatctgtct ctctcacatt tttcaactga tgagcgtgaa 2876821 aaaatctaac aaatattgtt tgaaaaatgt aaaataaata gaaaaagggg tcatattatg 2876881 gaaatggtat tagcattctt aggttttctg gcatgtctca ttgcactggg ctatggatta 2876941 tatcaccttg tcagatatgt actgaaaaag gaaaaacgtt tctcaaagag acttttttgg 2877001 ccgcttttca ttggaggcct tgtgctgctc tttaccgggg cagcattggc agaacctgac 2877061 actgccgcag caaatgccga gaaaaaatat tcagcgctaa acgccgaata taaaaacctc 2877121 acaaaagagc acgaagaact tgagaaagaa tataaatctg tcagctctga agcaaagaaa 2877181 ttaaaagaca acaaagaaga tcaagacaag cttgagaagc ttaaaaacga aaatagcgat 2877241 ctaaaaaaga ctcagaaatc attaaaagct gagattaaag agcttcaaga aaatcaaaag 2877301 cagctcaaag aagatgcaaa aacggcaaag gctgaaaatg aaacacttcg acaagataaa 2877361 acaaagcttg aaaatcaatt aaaagagacg gaaagccaaa ccgccagctc tcatgaagac 2877421 actggaagtt cttcaaacaa tacgagtaaa agtgatgaaa ccaaaacagc tgacaaagca 2877481 gaaggctgta atatcaaagg aagcagaaac ggcatctacc acacgccagg cagtacatac 2877541 tacgaccgga caaccgatcc ggctgaaatg ttttgctcag ttgaagaagc tgaagccgcc 2877601 ggttatcggg cgccaaaacg ataaacaaaa agctccagaa tgtctggagc tttttctgtt 2877661 tcacaacgac gatttaatga ccttcttata ataaagaact gacagaaaac caaaaatgga 2877721 gtagagcgca gtatataaca ccatcaccat aatcataggc gcccatacct ctgatccgaa 2877781 taagaaccag ccggattgga cggcaaagta actgtggaag aggccgacaa cgagcggaat 2877841 gccgaagttg tacatttgtt tgatgcgtat cccctttatc aggtcgccct gcgtaaagcc 2877901 gagttttctt aaaattgtat agctcggttt ttcatcttca ctttcaccca tttgtttaaa 2877961 ataaaggata caacctgatg taatcaggaa cgttaaccct aagaagccga cgatgaacat 2878021 caccatacca aacagtgatt tttgcgcagc gcttgtatct agtcttgata aatgctcgtt 2878081 tttcttgttc acctgttgaa aaagctcatt tgctttttcc atttgatcgt catgtttcac 2878141 attgacgccg ataaatgtag attgcgccag ctgaatgcgg gggtctttat ccttgtccag 2878201 ctgtttaaac aggctgtcat ccacaatgac agcgggcatg cccccgcttg taaacgtgta 2878261 ggacacaaga aactcttctc ttaatccttt atattttaat ggctgcgtct cgtgcttgct 2878321 ttttacttta ataacaccag agtccttgaa aaccattatt ttttgcagca agtcggtgta 2878381 tcctgagaaa acggcttctc cagccgccac atcgactcct tttacatctt tgtcgctaac 2878441 aacagcaagc tgcatattgc cgggatcgcc ctgcatctct ttcggagttc catccataat 2878501 atttgcaatg tcaacatttg cttgcaggac aggtgttgcc ttttttacaa acgagatgtt 2878561 gctttccctc aatttgtttt caaataactt ggcatctttc tcattcatga atgaaaaatc 2878621 agccgctaca ttttgttcag cggtcttttc cgacgagtaa tacgagatgt aagcaagaga 2878681 taacagcccg atggcgagcg ctgaaacggt tgtaataatc gtcagcagca gcgcattcga 2878741 tttcattctg aacatgatcg aagacagtga cagaacctca gaaatattta agtagccgcc 2878801 cttgcttttt cgaatgatat tcgagataaa cgtaactgat cctttataaa acaaaaacgt 2878861 cccgataatg acgctcccca gaatgaagct catcgcaaca aacagttcat taatggtctt 2878921 aaattttccg ccaaacagct cagaagacac atagtatcct gtcaaaatca acacgatgcc 2878981 taaagcgccg atcagcattt ggaaaaatga tattttcttc actttgtctt cagtggagga 2879041 cgttacttta aacaaagata aaatactctg ttttttgata aacgtataat tcatgatcat 2879101 gatcaaaagg taaatgccgc agaacacaat gaccgtttgg accaaggcct gctcagaaaa 2879161 atgcagtttc gcatccgctt tgacatcgac aattttgaac agaatcatca agacaagctt 2879221 cgatatcgaa aacccggccg ctaccccgat cgctaatgaa ccgaaataca gcatgacatt 2879281 ttctgcactt aagatgcgaa aaattttatg cttcgtcatt ccaattaatt gaaacagccc 2879341 gatttcttta ctccgtctct taataaaaat cgtattggca tataaaatga agatcgccac 2879401 tacagccaca agcaaaatcg aagcggtttt aatagccgcg gctcccttga ttgaagcctt 2879461 cacttcgtta attgctggat catactgcag cgtgacaaag gcgaaataaa gcgccacgct 2879521 aaagatgagc gcaaacacat acaaatagta attccggaga ttctttttca aatttcgcag 2879581 gatgagctga ttaatgttca tgctgcaccc cgcctaacac gccttgcgtt ttcataatat 2879641 cctggaaaaa cgtttgcctg tcctggcccc ctttattcag ctgtgtatac atttgcccgt 2879701 ccttaataaa aatgactctg ccgcagtagc tggcagcgac gggatcatgg gtaaccataa 2879761 taatcgtcgc gttgcgtttt tgattgagct ggctcagctt atttaataga tcggaggccg 2879821 atttcgaatc gagcgcgccg gtcggttcat cagcgaaaat aatgctcggg tcatgaataa 2879881 acgctcttcc agcggatgtt ctctgcttct ggccgccgga aatttcattc gggtatttat 2879941 cccgcaattc atatattccc agttccttgg caacttcctc aaacttgcga ttggcttcct 2880001 tttttgatag tttcgtgatc gataaaggca gaaggatatt ctctttcact gtcaatgtgt 2880061 ctaacaaatt gtaatcctga aagataaagc ctaaatgctg ttttctaaat tcagccagct 2880121 gcttttcctt catagccgtc atgtcatttc cattaatatg aatggttccg tgactgacct 2880181 gatcgattga ggacagaacg ttgagcaaag tggtttttcc cgacccggaa gcacccataa 2880241 tactgacgaa ttcgcccttt tcaatgtgaa tatcgatgcc cttcagcact tcctgtttat 2880301 tcagcttgtt tccataactt tttcgaattt tattcgcttc taaaatcacc atttacgcag 2880361 tctcctttat attggataat ctcattataa aaaggaatgc cgggcttttc cttcgatacg 2880421 gcgaacaaaa aagaaaagca tgtgacattt tcgtcacacg cttatgacat gttcaaattg 2880481 attccgtatt ggaaaggtta atgtaaaaac tgttcccgca ccaaactccg actcaacatc 2880541 aatatggatc aataacggcg ccgctgcttt ttttgccaag tacagcccca tgccagttga 2880601 cgcttgatca tggtgatccg ttgtggatgt aaacccttta tcaaaaatac gcggtacatc 2880661 ttttggatca atgcccctgc cacaatcttt cacttggagc tgcgtctgtt cccctttttg 2880721 aaagcttttg atctcgattt cagaggcttc gctgtatttc accgcgtttg tcagcagctg 2880781 cctgatgata aacgccagcc attttgcatc gctcagcact tctttggcct cgagctgtat 2880841 gtcaaaaccg atcccttttt ggatacacca cgattgtaaa tctttgattt ctttaaagat 2880901 caaaggctga agctgaatga attctactga caggtcgttt tcaataaatg aaatgcgttt 2880961 ttgatgaagc tgctgatcaa gaagcaggtg aatacgcagc cattcatatg acagctggga 2881021 tttcagtgct ttttcttcca ttctatcaat gattaaatgc atcgctgtta atggagtttt 2881081 gacctcatgg atccatgcca tcagctcatc tttttcattt tccaatgcta agcgatgccg 2881141 tgctgcggtc tgcttcaagt gttctgtttg cccggcaatg cttctttcaa ccattgcttc 2881201 aaacggcgtt tccggttcat ttatggctgt cacatcgaga ttgttctccc atgttttcaa 2881261 gcttttataa aacgctgttt ctttccgata gcggaaccaa aggaatatga taaaaaacaa 2881321 gatgcacaaa tacaccatat aaagtacatt cccaaatgat atggaaggat cgacaaaagc 2881381 aatgaacagc atcaaagcct gctgaaacaa aaacgcggca atccagctcc gcctttcgat 2881441 aaggaatgct ttaatcatag aacttgtcct cttccttcgc gatgtagccc tggcccacct 2881501 ttgtctcgat atatgcacca agctgcaggg cgtccagttt ttttcgcagg cgattgacat 2881561 tgacggtcag cgtattatca ctaacaaaac gctcatcgtt ccacaagctt ctgatcagct 2881621 cttcccggct gacgatcttg tttttttgct ctattaattg ttttagaatg aacatttcat 2881681 ttttggtcag ttcaacagat cctttgtcat tgctgacgag gttctgctcc gcgtctacag 2881741 cagcgccgca ccacgtttta atcgtactcg gctccgtatt ataatggtgc acacgccgga 2881801 acatcgcttg gattttcgcg atcagcacat caaaatgaaa tggcttttga ataaagtcat 2881861 ctgccccgag ctgcatggac atcaccatat cagcaggatg atcccgggag gataaaaaga 2881921 gaatcggaac atttgaccgg gagcggatca gacggcacca atgaaagccg tcaaatttag 2881981 gcagctgcac atcaataatg acacaatcag gattaaccgc cgcaaattcc tgcagcacct 2882041 gactgaaatc ctgaatgccg tatacatcat aggaccatcc cgttaaacga tccttgattt 2882101 catgaaacag cgattcatca tcttcaatca gcaaaagttt aaacaatcga ctcaccgcac 2882161 tttttccttt tttatcaagt gtatagcaaa acgccagcat gcgctataga aaaagccggc 2882221 tgtctcagcc ggctcgttcg cattataatt ctcttctcaa cgctgtcagc acgttggttt 2882281 tggtagcttt tctcgccggg ttcattccgg aaatgactgc gacccctccg caaatcacaa 2882341 cggcaatgat cacaaggctc gccgggatgt aggagaatgt gtaattcaaa tcgcccgcat 2882401 cgccaccgct tgtggccgca agaatcatcg gaacggccag gttgacaagg tagctcacgc 2882461 cgtaagaaat gataatccca atcacacagc ctaaaattcc gatatacgcg ctttccatca 2882521 agaacattcg gcgaatgatt gacgggctcg ccccaatcgc tttcataatg ccgatctctt 2882581 gcgttctctc tgtcaccgcc atcgtcatcg tgttaaaaat gccgatcgct gaaatgataa 2882641 ctgcgataca tccgacaaag atcagtccga ttttgaagac catgaagaag gtattggctc 2882701 cctcaagttc agtagtcact gatgtgacat agtacccgtc atctgttaga tcatttgtca 2882761 gctgttccac attctcaaac ttatcagcaa aaacaccaat gttcgtttca acatttccgc 2882821 ctttgaaatc taagaattcc gaaaaatctt ttttgaattg atcactgata aaaatatttg 2882881 agtcctccat ccagtcttga gatggttttt ttgtaatacc gacaatttta aagtcatatg 2882941 tttttgtttt tgtaacatcc cctgttttag aatctgtctt cgatacactt agttcaattg 2883001 ttttatttag aatatctttc gtatagccct ttggttcttt tatatcttct ggatttcctt 2883061 ttgcttcctc gatttttttg ttatattctt ccgattcttt tttcgttaat aatctctttg 2883121 cgaagtcgta tcctactacg atttcatttt ccgactttgc gactcttccc ttttccaatt 2883181 ccatattggc ctttaattca tcattcatat tagtaaaaat gagatttgag ctttcatttg 2883241 tacgattgcc taaagtagct ttgtttggtt catacacttg cgttctttct acaactgacc 2883301 ttacgtgatc atacttctct aaatcagctt ttttaatcgg cttgtctcct tccttgccca 2883361 ttacgctgac tttcgttaca atctgctggc tcattgtcat atctgtaatc gtcttttgaa 2883421 tcccaaatcc aacggacgac aacacaacca aaaacgcaca cgccattgtt gtcgccagaa 2883481 tcgtcataaa gacgcgaagc ctgtttttct tcatatttct tctgataaaa tgaacctgat 2883541 ccttaaacct caacggtaat tcctcctttt agcacaccat catgaagctg aaattttgaa 2883601 tgtccgatag aagcgacttc atcatcgtga gtaatgatca caaatgtaat gccacgctca 2883661 cgattcagct gctggatcaa ttccagcact tcatgttccg tttctgaatc aaggcttccc 2883721 gtcggctcat ccgctaagat aatcgaagga tttaaaatca atgctcgagc aatactgaca 2883781 cgctgctgct ggccgcctga cagttcattc ggataatgag cggcgtggtt ttccagaccg 2883841 acgcgtttca gcatgtcctg caccttttgc ttccgctcag atggcttgat tccttttaac 2883901 gccagcggca tttccacatt ctcatacgtc gttaaacccg ggatgagctg aaagctctga 2883961 aaaataaacc cgaaatggtc aagccgaaat tgcgcccatt ccttttcatt aaaccccgta 2884021 acatcagtgc cattaatgac aatccgccct tttgtcggcg atatgtagcc ggaaattaaa 2884081 ttcaaaagcg ttgatttccc tgagccgctt cgtccgacaa tgcaggcgat ttcccctttc 2884141 gccacgctca atgaaacatc cttcaatact ggaacttcat tctcacggcc cttttttccg 2884201 atcgtgaaag aatggtcgat atgctgaaca tcaatcatat gttctctctc ccttacaaaa 2884261 gtttcatttt tttataaatc gcaaaataac taatcaagaa accgattacc gcacctgtac 2884321 ccatgccaat gagataaccg gcaaagctct cgcttgcagt aaatccaaaa tagccgaagc 2884381 ccatgattcc tatgataata acgatgatct gcaccgggcg gttaagcggc ttccataaga 2884441 agaaatatcc gtttctttca ttagacattt taacaaagct aatatagccg atgatgtaaa 2884501 aaatgatagt catgatagcc ggaatgacta aataatatgg tgaattctca gcccatttcg 2884561 agtctacata aattatcgga atgaaatact gcacccattt aggtactgga ccatggataa 2884621 aatctattga tccgccaaaa aggatctcga ggttgatcac aggcaggctg atgagtaaaa 2884681 acggcgaaat ggccacggta aatgagacta gaagctgtgc gaaactattg cctgtcaaag 2884741 ctcctccggc cataaccaaa gaataagcca gcatgctaac aataatcatt cccaagctgt 2884801 aattgtgaaa ataaacggcc tgatctggct tcaaaagcat gatcagcaaa acagacaaaa 2884861 cataacctat gagctgcggc accacaatca ccattccgcc ggtaaggaac ttcgcatgaa 2884921 atatctgccc tcgtgtatat ggaaggctta atgtaaaatc aaagaagctc ttgctacgtt 2884981 caatcccaag ctggctgacc gccaaaacga ctccccaaat ccaaaacaat gagataaatg 2885041 agctatttaa ataatcaacg ctgaatacgc aggggccgac ccaattttct tttccagtga 2885101 cacagccttg atagatgaga tacatattta aaattgataa tggattacct aatataaaaa 2885161 ccaaaatggt gataactaag gcgactttat tctgccgcca ctctttgtaa agcagtccgg 2885221 aatccggcaa ctcacttccc tccaaaccta aggcatttct tacacttttg ttttcttata 2885281 aatagagaag tagctcacaa agaatccagc cactgctcca atgatcatac ccaaaatata 2885341 accaataatg gaatgtccgg tatagtatcc aaataaacca aatccaagga tgccgaaagc 2885401 cataaccaga atttgcaccg ggcgatctaa tctgttccat aagaaaaagt gtccgttccg 2885461 ttcacttgga agcttcttga agcttataaa gccaatcaag taaaatagca tgctcattac 2885521 ggctggaatc aataaaagat atttactgtt aatcagccat tcatttacaa cgtaactaat 2885581 cggtactagg ttcgataaat tgcttgccag agagaaataa ctctcagggg aagggaatat 2885641 ttcccatata ttcgcaccaa aaacaacttc taggtttcca accggcaatg caataattaa 2885701 atacggcaat atagctgctg aaaacgccgt taacagttgg gcaaaagcat ttccagttaa 2885761 cgctccggcg gccatcacca gtgaaaaagc cataaaactt atcacgatta ctccaatgct 2885821 gctgtgctca aaaaagtaga cgtgttcagg gttatagaca agaatcagca gccatgcaag 2885881 taaaaagcca atcaattgtg acagcacaat cacaaaaccg cctaaccaaa attttgtctg 2885941 aaaaatttgg cttctgttat acgggaggct taatataaaa tccatcgtgc ctttcgaacg 2886001 ctccattccg aggaagcaga ccgccaaaat gacacccggc acccagttga tatctatcag 2886061 attgcttatg gaataattca caataaaatc acaatattgc gggtcttggc gatcaagaca 2886121 cccttgataa gacaaatacg tattaacgat agaaagcgga tttgccaata ctaaaaacgc 2886181 gatacttaac aaaatcacca cttgattctg cttccactct cgatagagga gacctcggtc 2886241 taccatctcc gcttccctcc aaacttcgca atgaacactt cttccaggtt gacaggaagc 2886301 tcattccaca cttttggctt cagctctctc aaaaagctct ttttctcctc atcgcttttc 2886361 ggaatcagca ctgtgtaaaa cacgccggcc tgatcgagca tcggaatgtt ttgctctctg 2886421 atggccaaat tgacatctgt atcgaaggcc atttgaattt taatgtattc ttcttttaac 2886481 tcatcaagat ccatgacgtt ggtcaggctg ttatcttcaa gaaaaccaat tcggttgcac 2886541 atccgctcta tgtcttcaag ccggtgggac gtaatcagga tgctcgtatc acgctctgcc 2886601 acttcatcga ccatcagctg cagcacatca tgccttgtca ccgcatcaat accatccgtc 2886661 ggctcatcaa ggaggatcag cgccggtctc gccgcaaacg acagaacgag cgatagctgc 2886721 ttttttaagc ctgtcgacag ctcacggtat tttttcgttt ccggaatttc gtatctgttc 2886781 atcagctcat tcgcgtacgt gacatcaaat ttcggatata ttcttctcaa aatatcgact 2886841 aactgcttgt atgtatactt atcgtaaaac ggattttgaa caggcatgta gatgatattt 2886901 tgtttgactt tcgggtgctt tttgatttct acgccgtcaa ataaaatcgt tccgctgtca 2886961 gcgaaaatga tttgctggat taagcgaagc atcgtcgttt tgcccgatcc attgcgtcca 2887021 agcaatccaa agatttctcc tttttcgatt gttaatgaaa catcttttaa tacttgattg 2887081 ccgtcaatcg cttttgacag ctgccgcagt tcaatcattt tttttgcctc ccttcacatc 2887141 agcgctgatt tcctttatcc attcgtgcag tttttccagc tcaacccctg catagtgtgc 2887201 atcgatgatg agctgtttga gttgctcttt aatcatcgtc atcttccctt caaccagtgt 2887261 cgtttttgca ttctccgata tataggtccc tctgccccgc agcgtttcaa taatcccctc 2887321 tcgctcaagt tctttatacg ctttgctgac agtgttcgga ttcgcaataa tgatcgttgc 2887381 caattctctg acagaaggaa gcttatcacc aggcttcatg atccctttca aacaaagctc 2887441 tttcatttgc tgaataattt gttcgtaaat gggtgttgag cttcttggat cgatttgaat 2887501 catttacttc cctactttct atacgatctg aaccttttat agataaaaat gatcaattat 2887561 acttttttgc cattcaaaac cgatcatcac aagaacaaga aaaaaagaac aagcgatcac 2887621 agatgccgca atcagcattg gcacgttacg tttgtttcgt tttttatgtt tcataactgc 2887681 ctcccttaat gtcaatatat aaatgatttt atattagtgt ctatagtgta ttacttcaat 2887741 tagtacactt aatacaataa atactttgac tcacaaagtc aatccttttt ttacaaaaaa 2887801 acggaccctt ttaaaagggt ccgttttcct acacatcaag agggtgctgc aggatcatat 2887861 tattttgcaa agattgaagc tgaagtctca ttctgtacag ctgttctctc tgctgatcat 2887921 ttgacgacag ccatagttta ttcaaggcat ttaccgcatc ttctagctgc atttgtgcat 2887981 cactatattc ttgatcgtta taatgctctt gtttagaagc gattttcagc tgttcttcag 2888041 cataatcata ggcctgcata cattgctgga gatgttcatc tactgattgt cttgttgcca 2888101 cagtaacccc tcctcttggt aatggaaatc atccatcatt catattgtag cctcatctga 2888161 ctttattcaa taaagtaatt tatggtcgat attcatttgt tctcttgtga aatgcgtgct 2888221 acaattttag gatgcaatcg tacgcaagga ggcacatgaa ttgtgatgca gaacaatcct 2888281 tttccttatt caaatacgga aaaacgctat catacattga attatcatct cagagaacat 2888341 ttcggccata aggtgtttaa agtagcgctt gacggcggtt ttgactgtcc aaatcgggat 2888401 ggcaccgtag cccacggagg ctgtacgttt tgcagcgcag caggctccgg agattttgct 2888461 ggaaaccgga ccgatgattt aattacgcaa ttccatgaca tcaaaaaccg catgcacgaa 2888521 aaatggaagg acggcaagta catcgcttat tttcaggctt tcacaaacac tcacgccccg 2888581 gttgaggtgc ttcgtgagaa attcgaatcc gtcctcgcct tagatgatgt ggtcggcatt 2888641 tcgatcgcca cacgcccgga ctgtctgcct gatgatgtcg ttgattactt ggcagagctg 2888701 aatgaacgta cgtatttgtg ggtggagctt gggcttcaaa cagttcatga acggactgca 2888761 cttttgatca accgcgcaca tgattttaac tgctatgtgg aaggcgtcaa taaattaaga 2888821 aaacacggca tacgtgtctg ctcgcatatt atcaacgggc tgcctttgga agaccgggac 2888881 atgatgatgg aaacggcaaa ggccgtcgca gatttggatg tccagggcat taaaatccat 2888941 ctgcttcacc tactgaaagg cacgccgatg gtcaaacaat atgaaaaggg caagctggaa 2889001 tttctttctc aagatgatta tgtgcagctc gtctgcgatc agcttgagat cattccgcct 2889061 gaaatgatcg tccaccgcat tacaggtgac ggaccgattg agttgatgat cgggccaatg 2889121 tggagcgtca acaaatggga agtgcttggc gccattaata aagagctaga aaatcgaggc 2889181 agctatcaag gaaagttctt tcaacggctt gaggaggaat cagcgctatg attttgaaga 2889241 aaattcttcc ttacagcaaa gaactgctga aaatggccgc gggagaggga gatattgtcg 2889301 tagatgcgac aatgggcaac ggacatgata cacagttttt agcggagctt gtcggtgaaa 2889361 acggccatgt atacgcattc gacatccaag aatcagccgt ggccaataca aaggaacggc 2889421 tcggtgacat gtatcaagcg cgaacaacgt tatttcacaa aagccatgat aaaatcgctg 2889481 aatccctccc gcctgaaaca catggcaaag tggcggccgc ggtatttaac ctcggctatt 2889541 tgccgggcgg ggacaaatca attacgacaa acggcagttc tacgatcaaa gccattgaac 2889601 agcttctcag catcatgaaa gacgaaggtc tgattgttct cgtcgtctat catggccacc 2889661 cggaaggcaa agctgaaaaa aacgacgtgc tcgagttttg ccgggacttg gaccagcaaa 2889721 cagcccgtgt attaacatac gggtttatca atcagcaaaa tgacccgcca tttattgtcg 2889781 ccatcgaaaa aaaagctcag atcagcaaat gatttgagct tttttctttg aatttttcat 2889841 ccaggacatt ttttgaaatt tccggtaggc tctgccgttg atataaaaga aaagggaggt 2889901 ttttccgctg gctttgatca gcttctttgc gagccggccc atttcctttt ggcctgccac 2889961 tttatcatct gacaaataaa cgccaagcaa gccgcgattg attaaacgat ggaagttttc 2890021 atgcggaatg ccttgtaaat gctcgtcggc tttatggata aagtgttcaa gccggtccat 2890081 catctcttca tgagactgat aatacgagca gaaattcaag tctccttcca gcaagtcctc 2890141 ctcttgatca atcaaataat caagaagaat atgaagaccc tgtatgtaag gaaaataact 2890201 gtctcggatt tttttagcgg tgctttctgt gaaatcaggc tggaacgaat acgcaaccag 2890261 acagaaaatg cctaacgttg agcctgcaca ggctgaaaat tcataccatt ccatctcagg 2890321 cagctctgat tcatattgag taaaccactt ttcaagccgc ggaacacgct catgctcaat 2890381 aacgtgctta tgcacctgca aatcgcaata atagccgcac agttcaagca gataaggttt 2890441 aatcatgtca tagtgctcaa tggagccgag aacacgctgg cacgttttaa ccagttcatg 2890501 caaatatccg ctgtcatcct gttcttccct gaattgataa tagttttgca gttccgcccc 2890561 aactgtcagt gcgtcctgca ttgaggcatg gagcatccga aaatcctgcg ggtccagcga 2890621 ggtgctgcgg tcacacagat tgtccaaata atcactaatc gtttgatacg cgatgataaa 2890681 ctcgacacat ttctgctttt ggctgcctga caataaggcc agtatgccgc cgccttcaca 2890741 gtgaaacgtt ttgtcccgaa tacttgcggt tgcctgtgct ttcaattcac tgttatgaat 2890801 cgattctgat ttttgcttcc atatgtccag ctcttgatga acgagcggaa aaatatctcg 2890861 atataccttt gccatcaatc caaaaggatg ttccggtact gtcaacacat gcacccccta 2890921 ctagttcaaa tatattgatc agtaaacgct cttgctgctt taaaaacatc ttctctctcg 2890981 ggttcattga agatctcatg gtaaagccct tcccactctc tgtatgcttt attatgagaa 2891041 gcaacaccat taaaccactt gatgaccatc gttttgtcaa caagcttgtc atcaccggct 2891101 tgcatcacaa gaagcggaac tttcaaaaat gcctctgtcg gcaccattgc cgattcaatt 2891161 gtctttaaaa gctctctgta ccatctgaca gaaactttcc tgacgtataa cgaatcattt 2891221 tggtcagctt cgatgacgtc ctcattgcgc gtcgccatat caattgataa tcccgaatca 2891281 accttaagtg acggagcgat gacattcagg ccttttgatg caagatcaag cgctttattc 2891341 actttaattt gcagtccgag acacggtgat gataaaataa ttcccgtaat ccggggattt 2891401 ctttgctgtt taacccattc aatcgcgacc agaccgccca tgctgtgacc tagaagaaaa 2891461 accggaagat caaaggttcg cgctttatct atccaagcat ctacttcatc aatgtattct 2891521 tgaaacgagc gaatatgccc tctcgctctt gtcgttgttc cctgtccagg caaatcgccc 2891581 atgacaacgt gataacccga agaccgccac atttcaatca gccatttata tcgtccgtga 2891641 tattcacttg ccccgtgaat gattacaatc acggcaacag gtctgtctgc tttccaggtc 2891701 cacatgatct tcacctcata cgaaatttaa atagagaaag aaggatgaat cttatgatct 2891761 acccttataa ggaacacaag ccagatatcc acccaacagc ctttatagct gataatgcaa 2891821 caattaccgg tgatgtcgtg atcggagaac agtccagcat ttggttttct gttgtcataa 2891881 ggggagatgt tgcgccgacc agaatcggaa acagagtcaa tatccaagat ttaagctgcc 2891941 tccatcaaag cccgaacaag acgctactca ttgaagatga cgccacgata ggccatcagg 2892001 ttacacttca tagcgctgtt atccgcaaga acgccttaat cgggatgggc tcaatcattt 2892061 tagacggagc cgaaattggc gaaggcgctt ttattggtgc cggcagtctt gtcccgcccg 2892121 gaaaaatcat tccgcctggc catctcgcct ttggccgccc tgcaaaagtc atccgccctt 2892181 tgacggaaga agaccgaaaa gatatgcaaa gaatacggtc agaatatgta gaaaagggcc 2892241 aatattataa atttcttcaa caaacataag acctgcttcg tcttacttta ccatttttca 2892301 aattatattt gaaagcaata accatcgtta acccggacgt catacagttc gggtttcgat 2892361 ttttccataa aacgttcaca tatagcatga aacgtatgac ttttatctta tcacaaaact 2892421 ataaacagcc tctgcaaaaa cacataccta ttctttcctg ttctctattt tctatgagca 2892481 cacacaaaaa gagcccactg ggagctcttt ttgtcagctg atatttcgtt cgctggcagc 2892541 agccgcattt tttttatgaa acccttttcc atagtacaca gccagcaaga tgagaaacca 2892601 tatcggcccg ataatcacgg ctactcttgt atcagggctg taagccataa gaatgacgac 2892661 gaatgctaga aatgccaatg acacataaga cgtaaacgga aataaaggca ttttgtactt 2892721 taattgtttc ttttcttccg gcttcaaact tttcctgtat tttatttgag aaagcaaaat 2892781 gattgcccac gtccaaatcg ctccgaacgt cgcaatactt gtaacccaag taaatacctt 2892841 cgcagggaca acatagttta acagcactcc gactaataaa gcgcccgctg aagccagaac 2892901 agctttaccc gggatgccgc ctttcgtcag ctgaccatat gcttgtggcg cctctttctg 2892961 ttccgccaag ttaaacagca tccgccctgt gctgaaaata ccactgttgc atgaagacag 2893021 cgcggctgtc aacacgacaa agttaatgat acctgcggcc gatggaatgc ccactttttg 2893081 aaatgtgaga acaaatggac ttccttgaga gccaatttcc tgccacggat aaatagacat 2893141 aatgacaaat aaagcgccta cataaaaaat caaaatccgc caaaatactg tatcgattgc 2893201 tttggctaac gatttttgcg ggttttttac ttcgccagcc gtcaccccga tcatttcaat 2893261 ccctaaatag gcgaacatga ccatttgaag agacaataaa acccctttta atccatgagg 2893321 gaaaaatcct ccgttgttcc acaaattgct gattccggtt gcaatgcccc cattgccgac 2893381 tcctgcaata atcatcaata aaccgacagc aatcatggat aagattgcaa caattttaat 2893441 caatgcgaac caaaattcca gctcgccgta agctttgaca gccaggaaat taacacccgt 2893501 cataatgacc agtgccgata acgcccaaat ccagtttggc acgtccggaa accagaaccc 2893561 catatagatg ccgacagcag tgatttcggc catacaggtg acaacccata aaaaccagta 2893621 gttccaacct gttaaatagc ctgcaagcgg tcccaaataa tcacgcgcat acctgctgaa 2893681 ggagcctgcg accggttttt gaatggccat ttccccaagc gctctcataa taaaaaacat 2893741 gaccaggccg cttgcggcat acgctaccaa aataccaggc cctgctaatt gaatagctga 2893801 tgcggagccg aggaacaacc ctactcctat agcagctcct aaagacatta aagaaatatg 2893861 cctttcttcg agtccgcggt gcagctcttg tttttgtttt tgcatgcttc ttctccccta 2893921 gaaaaaaata tcattatatc atttttctga atattccgta cggattgggt aaatcaatga 2893981 tgatggagaa ataaaaggat aacaacaagg ctttcgacta ctcgaaagcc ttgttgtctg 2894041 ttacacaaag atgacttctt taggctgatg gctcagctct tcaggcatat accgtttttc 2894101 aatattgatg ctgtgccaga tcataaagat tagcacagtc caaattttac ggctgttatc 2894161 agccttgtcc gcacaatggt cttcaagaag ctgaaggaca taatccttat ggatataagc 2894221 atccgtttgg ctttcttgaa taatattccg cacccattcg ttcatttcgt ttttcagcca 2894281 atgacggatc ggtacaggga aaccaagctt tttgcggttt aatacgtgct caggcacaat 2894341 tccttcagcg gctttgcgaa gaagatactt cgtcgtgccg ttcttcgttt tcagctcatc 2894401 aggaattttt gaagcgacgt cgaatacgac tttatccaag aacggcacac gcagttccaa 2894461 agaattcgcc atcgtcattt tatccgcctt taacaaaatg tcgccgcgca tccaagtgtg 2894521 gatatcgaca tactgcattt tgttgatatc gctgtacgag ctgctttctg taaagtaagt 2894581 cttcgtcaca tcgcgatatg aaaggttcgg attataatgc ttcaacagct gctttttgac 2894641 agactcttca aagattttcg cgttaccgat ataacgatcc tgaagcggag tgcagccgcg 2894701 ctcaagcagg ctcttccctc tcataccttc aggcataacg gcagcaacgt gcagaagcat 2894761 ctttttcaag ccggacggaa tccgttcaaa cggtttaagc gaaagcggtt cacggtaaat 2894821 gttatatccg ccgaagagct catccgctcc ttcacctgat aaagcaaccg taacatgttt 2894881 ttttgcttct tttgcaacaa agtacaacgg aatcgctgcc ggatcagcaa gcgggtcatc 2894941 aaaatgccat acgatcttcg gaagctcatt catgtattcc tcaggcgaaa tgactttgct 2895001 gatattttca atgcccagcg ccgctgccgt ttctttcgct acatcaacct cactgaagcc 2895061 ctgctgttca aagccgacag agaatgtttt taagcttgga tgaaattcct tcgcaacaga 2895121 cacaataaag gaagaatcaa tcccgccaga caggaacgaa ccgacaggaa cgtcacttct 2895181 catatgaacg tttacagagt catagatcgc gtctcggact tctttcacaa gcttgtcttc 2895241 ttcagtctga accggcttga agttcgcttt gaaatacgtt ttgaatgtga tatcgccgtc 2895301 cgggcggatt gtgaattgtg aacccggctc tacttttttc acatgggcat caagcgtgct 2895361 tggttcagga acaaattgga aagacatgta ctgctgcaat gcctctttat ctatttcaat 2895421 atcattctga gcaaccatta aactttttct ctctgaggca aaataaacct gatcattgat 2895481 cgttgtgtag tacaacggtt taatgccgaa tggatctctt gccccataaa gcacatgatc 2895541 gtttttattc caaatcagaa aggcaaacat accgcgcagt ttggacgccg cttcttcttt 2895601 atagtgacgg taagtcgcaa gaagaacctc tgtgtccgaa tccgtgttga atgtgtaccc 2895661 ctttgcttca agttcttctc tcagttcgat atagttatag atttctccgt taaagataat 2895721 ccaatatgtt tcatcttcat atgataaagg ctgtccacca ttttctacat caataatgct 2895781 gagccgtctg aatccgaagc cgacgtgctc atcatggaaa tatccatcac tgtcaggacc 2895841 gcggtgaacg atcatttggt tcatttgttt gattagttct tcttgatcag cggtttgagc 2895901 taacggatgc ttgttaaaaa ccccgacaaa tccacacata gtattgcctc cataattaaa 2895961 attgtcatca ttgaacccct atttatagac gctgtgaata gtatttggtt tcacagttat 2896021 gtaaaaaaat aaacatgaat acaacgataa aaaagggaaa gccgcttaac cagtaagcgg 2896081 ctataaaatt attctcctaa cgcttcttta cgcagctgct ccgctttgtc tgtgcgctcc 2896141 catggaaggt caacatcgtg acgtccaaag tggccgtacg cagcagtttg tttatagatc 2896201 ggacggcgca aatcaagcat tttgataatg ccggcaggtc gtaaatcaaa gttattgcga 2896261 acaacttcaa tcagtttttc ctcagaagct tttcctgaac cgaatgtgtt gattgagatt 2896321 gacacaggct gtgcaacacc gatcgcgtaa gcaagctgta cttcgcaaga atcagcaagc 2896381 tcagccgcaa cgatgttttt cgcaacgtat cttgccgcat aagctgcaga acggtctacc 2896441 ttcgtcgcgt ccttacctga gaacgcgcct ccgccgtggc gtgcatagcc gccgtacgta 2896501 tcaacgatga ttttgcgtcc tgtaagtccc gcatcccctt gagggcctcc gattacgaaa 2896561 cgtcctgtag ggttgatgaa atattttgtt tcttcatcaa tcagctcttc aggaacaacc 2896621 ggattgatta catgttcttt aatgttgcgc tgaatttgct caagtgtaat ttcagggtga 2896681 tgctgagttg aaataacaat cgcgtcaatg cggactggtt tgttattttc atcgtactca 2896741 accgttacct gtgttttgcc gtcagggcga aggtacggaa gaatatcttc tttacggact 2896801 tcacttaggc ggcgggctaa tttatgggca agtgaaattg gaagaggcat aagctctttc 2896861 gtttcgttgc acgcataacc gaacattaat ccttggtcac ccgcaccaat cgcttcaatt 2896921 tcttcgtcgc tcattgtgcc ttcacgggct tcaagcgctt ggtctacgcc catcgcgata 2896981 tcagcagact gctcatcaat tgatgttaaa accgcacaag tttccgcatc aaatccgtat 2897041 tttgcacgtg tgtatccgat ttctttaatg gtttggcgaa ccgttttcgg aatgtcaaca 2897101 tacgtagaag ttgtgatctc tccgcttaca agaaccaaac ctgttgtcac agatgtttca 2897161 caagcaacac gcgcgttagg gtctttcttt aaaatttcat ctaaaatgct gtcagaaatc 2897221 tggtcacaga ttttatccgg atgcccctcc gtaacagatt ctgatgtaaa taaacgacga 2897281 tttttactca tgatttgctt cctcctgcac aaggcctccc gaaagacctt gtatatatga 2897341 tacggaactc gctccctctt atacaatgta cagttatatt agagaatgtt aattggcata 2897401 tttatgaaat aaaaaaacct tttccatcga ggaaagggtt tggtctttgt gcctttcact 2897461 cttatcgctc aaggaatcat acaaccttgc aacaggttag caccttggtt gtctcactca 2897521 gttgaacata ataaataaca gagaaaccgg ttgctgggct tcatagggcc tgtccctccg 2897581 ccagctcggg ataagagtat ccgctcaatg aaatatctta tcgtaaaagg gtttgcaatg 2897641 tcaatatgat tcagaagaaa taggcaccta tattgaggga aaacaatgga aatgcacaca 2897701 caaaaaacaa taaatagtat agactatttg aaaatatatg ttatactaat tcacaattag 2897761 caaaacacaa aaaacgataa aggaaggttt catatgaact cagttgattt gaccgctgat 2897821 ttacaagcct tattaacatg tccaaatgtg cgtcataatt tatcagcagc acagctaaca 2897881 gaaaaagtcc tctcccgaaa cgaaggcatt ttaacatcca caggtgctgt tcgcgcgaca 2897941 acaggcgctt acacaggacg ctcacctaaa gataaattca tcgtggagga agaaagcacg 2898001 aaaaataaga tcgattgggg cccggtgaat cagccgattt cagaagaagc gtttgagcgg 2898061 ctgtacacga aagttgtcag ctatttaaag gagcgagatg aactgtttgt tttcgaagga 2898121 tttgccggag cagacgagaa atacaggctg ccgatcactg tcgtaaatga gttcgcatgg 2898181 cacaatttat ttgcgcggca gctgtttatc cgtccggaag gaaatgataa gaaaacagtt 2898241 gagcagccgt tcaccattct ttctgctccg catttcaaag cggatccaaa aacagacggc 2898301 actcattccg aaacgtttat tattgtctct ttcgaaaagc ggacaatttt aatcggcgga 2898361 actgagtatg ccggtgaaat gaagaagtcc attttctcca ttatgaattt cctgctgcct 2898421 gaaagagata ttttatctat gcactgctcc gccaatgtcg gtgaaaaagg cgatgtcgcc 2898481 cttttcttcg gactgtcagg aacaggaaag accaccctgt cggcagatgc tgaccgcaag 2898541 ctgatcggtg acgatgaaca tggctggtct gatacaggcg tctttaatat tgaaggcgga 2898601 tgctacgcta agtgtattca tttaagcgag gaaaaggagc cgcaaatctt taacgcgatc 2898661 cgcttcgggt ctgttctcga aaatgtcgtt gtggatgaag atacacgcga agccaattat 2898721 gatgattcct tctatactga aaacacgcgg gcagcttacc cgattcatat gattaataac 2898781 atcgtgactc caagcatggc cggccatccg tcagccattg tatttttgac ggctgatgcc 2898841 ttcggagtcc tgccgccgat cagcaaacta acgaaggagc aggcgatgta ccattttttg 2898901 agcggttaca cgagtaagct tgccggaacc gaacgtggtg tcacgtctcc tgaaacgacg 2898961 ttttctacat gcttcggctc accgttcctg ccgcttcctg ctcacgtcta tgctgaaatg 2899021 ctcggcaaaa agatcgatga acacggcgca gacgttttct tagtcaatac cggatggacc 2899081 gggggcggct acggcacagg cgaacgaatg aagctttctt acactagagc aatggtcaaa 2899141 gcagcgattg aaggcaaatt agaggatgct gaaatgataa ctgacgatat tttcggcctg 2899201 cacattccgg cccatgttcc tggcgttcct gatcatatcc ttcagcctga aaacacgtgg 2899261 accaacaagg aagaatacaa agaaaaagca gtctaccttg caaatgaatt caaagagaac 2899321 tttaaaaagt tcgcacatac cgatgccatc gcccaggcag gcggccctct cgtataaaaa 2899381 acaaaagcca agagcaatta tgctcttggc ttgttttaat tgacggaatg caaagaagtc 2899441 agcttgtatg taatgatggt ccggccttct tcccattgaa gcttctgcac ttcagctgtg 2899501 cctgactttt cgccaaactt tgttttgcgt acatccattg gaatctccat cggatatact 2899561 cggtatccgt ccttctctaa cgtgaatata ttttcatcta tgcgaacttc ttttcctttt 2899621 gtcacaatca gtgtattaaa ttcaacaggc attcccaaag tgaaatcccc tttcgttctc 2899681 ttttttcttt atcataacat atttcactgt cagcggtttt tcatccattg tgtgagctgc 2899741 cgcacgatac gccggttttc ttttggcggg aaataatgtg tgaatgtact gtagtaccat 2899801 gtttccaccg gcttatgcag ttgttttagc ttctcttcta ataaatagga atgctgaatc 2899861 gaaacatttt ggtctttttc tccatggatt aacagcacgg gagcctgaat tttgtttact 2899921 tggtcaaacg gtgtcctcca ttgatattcc tcaggcacct ttttcggtgt tccgccgatg 2899981 actcttttca tcattcgccg caaatcctgc cgctcctcgt atgtaagaat catatcactg 2900041 acgcctcccc aggaaacaaa tgaagctgcc tgcccgccca tttcgatcgc agtgagcatt 2900101 cccataattc cgccgcggga aaaaccgaag atatggattc tatccttctt gacatttggg 2900161 tgctgctgaa gcaggcgaaa agcagaaaat gcatcctccc tgtcttctcc ggcaaaatcc 2900221 tcattgcctt ctcctccttg attgcctctg taaaaaggag caaacaccac aaacccttgg 2900281 gatgcaaact ggataatccg gcccggccga accatgccca cgcttttaat cccgccgcgc 2900341 aaatataaaa atccgtcata ttgtcccggt tccgccggct cagccagaag ccccttaacc 2900401 cgtaatccat ttgacagata gcagatcgta tacaaacgca catgctggct tggcgacgga 2900461 aatcttcttt tctctacaat caaaacagcc gcctcctttt ttctatatgc tttccttact 2900521 ccaaaattac atccggagaa cctggttagg cattcacaca tttttatacc catcatacga 2900581 tatgtaaagc aaaaaaggat attaacttga tgcgaaataa ggaggttgtc tatgtgaaca 2900641 gatggttaag gctgggcttc gcctgtgtcg gcagtatctt tctgatgttc gccctggcgg 2900701 cttgcaagca ggaagaaacg ctcaccaaag tcaaagtagc tgaagtgacc cattcaattt 2900761 tttacgcacc tttatatgtt gctgagtcta aaggtttttt taaggaagaa gggcttgatg 2900821 tcgatgtgaa tacgacctgg ggcggagata aaacgatgac atcgcttctt tccaacggct 2900881 ccgacatcgc gcttgtcggg tcagaaacat ctatttatgt cgaagcgcaa ggggctaaag 2900941 atcccgtcat taatttcgcc cagctgactc agacagacgg aacgtttctt gtcgcgagag 2901001 aagatgttga acacttcgac tgggatcagc tgaaaggaaa aacgtttctc ggtcagcgaa 2901061 aaggcggcat gccgcaaatg gtcggcgagt atgtactgaa caaacataag attgacccgc 2901121 ataaggatat agacctcatc cagaacatag acttcgccaa tattgccaat gcgtttgctt 2901181 ctggaaccgg tgagtatgta cagctctttg aaccgcaggc ttctctcttt gagaaaaaag 2901241 gcatcggcca tatcgtggct tcattcggag aagaatcagg agaggttcct tatacgactt 2901301 ttatggcgaa acaaagctat ttgaagaaaa atgaagacac agccgtcaag tttacaaaag 2901361 ccatttataa ggcgcagcag tgggttgaaa atcattctgc gaaggacatc acagatgcca 2901421 ttaaagatga atttgatgat accgacccag acgtcatcga aacatccatt gaacgctata 2901481 aaaaacagca ttcatattca ccagaccctc tgcttaacga aaaagaatgg gagcttctcc 2901541 aaaccattat ggataaatcg ggagaactgc cgaagcacat tccatacaat cagcttgtaa 2901601 ataaagaaat tgctgaaaaa gtcacctcgg agaaatagga ggcgccatct atgtctttct 2901661 tacatgtcga ccatgtaacc catacttatt tttctattaa agaaaaaaca acggctgtgc 2901721 gggatattca tttcgatgcc gaaaaaggcg atttcatctc atttctcggc ccaagcggct 2901781 gcggaaaaac aacattgctt tccattattg ccggtttgat tgagccatca gaaggcagag 2901841 ttctgattga aggccgtgag ccgaatcaaa aagaacataa tattggctat atgcttcagc 2901901 aggattactt atttccctgg aaatctatcg aggaaaatgt gcttctcggt ttaaaaatcg 2901961 ccgacacgct gacagaagaa agcaaagccg ctgcactcgg tctattgccg gagttcggcc 2902021 tcatagatgt ggagaaaaaa tatccgaaag aactgtcagg cgggatgcgc cagcgggctg 2902081 cgcttgcaag aacacttgcg cctaacccta gtctgctttt gctggatgag ccattttccg 2902141 cgcttgattt tcagacaaag ctgtctttgg aaaacctggt attccgcaca ttaaaggaat 2902201 atcaaaaaac agcagtgctt gtcactcatg atatagggga agcgatagcg atgagcgata 2902261 cgatcttttt attttcaaat cagccgggca ccatccatca gatttttacc attcctaagg 2902321 aattggccgc gatgttgcct tttgacgccc gtcaggaacc ttccttccag acactgtttc 2902381 aaacgatatg gaaggagctg aattctcttg agaaacagca aagaaaccat tgatctgctt 2902441 cacgagcagt atcaattcaa acagaaaaag gaaaagtgga aggtccattc ctttcagctt 2902501 gccatattta ttctcttttt ctcgggctgg gaaatctcca gcaggcaggg ctggatcgat 2902561 ccgctgatct tcagctctcc atcagctgtg tggcgattat tgctggagaa acttggtgac 2902621 ggttctttac tgtcacacat cggcgtcact ttatttgaaa cggtgcttgg ctttttgctc 2902681 gggacgttta tgggcacgtg cctagccgct ttgttatggt ggtctaaccg acttgccaga 2902741 attttagatc cgtatcttgt gattttgaac gcaatgccga aagtggccct gggcccgatc 2902801 ctgattgtcg cgctcggtcc cagttttatc agcatcattg cgatgggagc catcatcagc 2902861 gtcattatca caaccatcgt tgtctacacc gccttccaag aggtcgacga aaactatacg 2902921 aaagtcatga aaacattcgg cgcaaaaaag tgggttattt ttaaagaagt catactgcct 2902981 gcatcctccc ccgcgattat ttcaacacta aaagtgaacg tcggtttatc atgggttggc 2903041 gttattgtag gggaattcct cgtttcgaag gtcggattag gatatatgat tatttacgga 2903101 ttccaagtct tcaattttac actcgtcttc ttaagcctgc tgatcatcgc catcttcgcc 2903161 actctgatgt atcagggcgt cgagctgctg gaaaagaaat ggacgaaggg gaggacataa 2903221 aaaacccggc acatgtgccg ggttttttat tcaatccatc cagattcttt cagttttttc 2903281 aagctgatcg gaagaacgga atccttcata ataaagctga attttttatt gcgggaaagg 2903341 ttctccggca gctcgtgaaa caaaaccggg cctttcgttt caaagtaatc agcctgcttt 2903401 tcaagctttt ctatatctgc aaaatatata ttttttacaa tcactttttc ttttccgaga 2903461 actttatact gtccgagata cttgaggctt ttgactctcg cgcccgtctc ttcctttact 2903521 tcccggagcg cagcctcttc tgcgcactcc atcggctcta ctttcccgcc tggaaactca 2903581 tagcctctgt cctcatgttc tgttaaaagc catttgccgc caaaacggca aatcacccag 2903641 acatgcttcg ggctgtccga gaaaggctga tcgtcaaagg aaagctgaac agtattctga 2903701 taataatctt taaactcgta catgtttatc cctcaaatcc gttcctagct atcttccata 2903761 catcatacca cagttacgtt tcttcggaag ccttttatca aaaaataagg gaaacccagc 2903821 acgccgtcag gttctgcatg cagactagct cgtacagttt ttttgcgata cttttgccgg 2903881 aaagtgcgac cgacgctctg ggctttatta tgacccgcga acagggaaaa gttacggttt 2903941 gcgcttaaat ttatttttta acgtttctaa aagatcgaca agcatctgag gaaccggtat 2904001 gccaagagag ctggctgtca caacaatttg cacagattca taaagaatat aaaacataat 2904061 agccaagtca cgaattgatc cctgtgtatt cagcagctga tcaaaaaagt ggcatacaga 2904121 gatcagagcc agcgtgacta attttttgac aagccgggca aatacctttt taaatgacag 2904181 tttgtgaata atggtttcct tcaaagtcgt actgataaat tcaattgcca taagagagag 2904241 caaaatcaga aatgaatact gaaaacctcc aaagaaaaaa cccgctgctg aaacgctgac 2904301 tgctaaaaac gaaaagatgc caaagtctct atccatttat cccaacatcc tttcacagaa 2904361 acggccttac gatattctat ggtaaacaag ccgaacggat tggatttttc agaaaaatgg 2904421 actggttgtc gcctattttt cagatacaaa aagaaaagcc ggacgtcttt tttaagacat 2904481 ccggccgttc tatttttgaa cttaacctag gtaagctttt agcatccagt tatgtttttc 2904541 aatattttga tggatcgcaa gaagcatgtc ccctgttgtt tcgtcaccga cttcatcagc 2904601 taaatccatg ccgtttttca gctcttccgc gatgactgtg aaatcatcat atacgctttg 2904661 aaccatttgt tcagctgttt catttccagc agcttctttg acagaagccg tttctaagga 2904721 ttccttcatt gttgcaatcg gttttccgtt cagcgccaaa agacgttctg ctaagtcatc 2904781 aatataagtt gctgtttcgt tgtacagctc ctcaaacttt tcatgaagag tgaagaaatc 2904841 tttccctttc acataccagt gataattatg tagtttcaca tacatgaccg tccagttggc 2904901 tacttgtttg ttcactgctt gaatcaattg ttctgacatg gtatctcctc cttgttatat 2904961 gactatgtat acccttaata tcgtacgcta aaacctcttt tttaccctta tctgtcacga 2905021 tttcttctat tatgctacaa ttgttaaaaa acgggaggtg gaatgtcatg acgcttctca 2905081 ttacgataag tattttgatt gtgctggctg ttttgcttgt aaccatttgg acgactgtaa 2905141 aagcctataa tgtaaagcat accattgatc caccacaaga aaatcactct gattcacaca 2905201 atcaatgatg atgtgaatgc tcctcttctg actgattgct ggcagcatcg gcgtctccga 2905261 cttggacttt taaggtcggc atgctatgct gtttttttgc tgtgacatga gattggacag 2905321 tgtatacacc atcttcctta aacgtcgttt ccaatcggta tacgcctttt tcttgtttca 2905381 ccttaaacat ttggcttgcg tctttttccc cttctttcca tacttcaaac tctacttcat 2905441 cggcatccgt cacagcttca tcaccatatg atacagctgc ttcataagca gcgctttctc 2905501 cgggatttac tttttcaggc ccggtcagct tgacatccaa aacctcgggc gtctcagctg 2905561 tatttgcttt actttcacca gatccgcatc cattaagcaa taaagcagaa aaaagcagaa 2905621 caaccaacat ctttttcatg ccatcaccct ttcatcgttt acctaaatag tagcaaacgc 2905681 ttacagcaaa tggtacacaa aatatgagac gtcacaaaaa agaccttttt gcttaagcgc 2905741 aaaaaggtcc tttctatttt agccaaatac ttttagcaat tcttctttat cctgtgaaag 2905801 ccagaaacgc attaaacgtt tagcgccttc cagatcatga agcttcgctt ggccgcactg 2905861 cttttcattc gcagcaggta tttctgtaat ctctaccgct tccttcattg tgtcttcaag 2905921 cagatcaacg atttccgctg atgtcggctc tccgctcaca actagataat agcctgtctg 2905981 gcagcccatt ggagaaatat caatgatatc aaaatgatcg tatttctcag cgtgagaacg 2906041 aatcgtaaac gcgagcaaat gctcgagtgt gtgaatggtg tcaggcttca tcgcctgttt 2906101 atttggctgg caaaaacgaa tgtcaaattt atttacaacg ccgtctgttc ccactttatg 2906161 cacgccgcaa tgtcttacat atggagcaac aaccgcatta tgatcaagct caaaactttc 2906221 tactgaaggc ataatggcac tctccccttt tttaaaaatg taatttcatt ataacatact 2906281 tttccgataa gaattattga ttaacttttc aatctgtgtt ttttttctta tacttgcatc 2906341 agaaaggttg ctgaagaaac atgaaaaccc tattcatcgc tctgatcaga ggatatcaaa 2906401 aattcatctc gcccctgaca ccgccaacgt gccgctttta tccgacctgt tcccaatatg 2906461 gaatcgaagc gattaaaaca catggcgctt taaaaggcgg atggctgaca atcaaacgga 2906521 ttttgaaatg ccacccgttc catccgggag gagtcgatcc cgttcctgaa aagaaacaaa 2906581 aacattaatt gttataaccg tttacgataa gatccagttt tccggtttta ggatcaatga 2906641 ctaagccatg gaccggaacg ttttcaggga acagcgggtg atgtttaata acatctacgc 2906701 tgtctttcac actcgcttcc actgaatcaa agcttttaaa ccattgatca aagtctacac 2906761 cggagtactt tattgtttcg atgcgttctt ccggaatccc tcttgctttg attttttcaa 2906821 gcatgctttt gctgctgatt ttgctcatgc cgcaatcgtg atgcccgatc acacacacct 2906881 catctgcatt cagctcgtac actgcgacga gtatacttct catgatgctt ccgaatgggt 2906941 gtgtcacaag cgcaccggca cttttaatga ttttcacatc accgtttcgc aaattcatcg 2907001 catgcggcag cagttcaacc agacgagtat ccatgcaaga aagaatcgcc atttttttat 2907061 ctggaaattt tgatgtttga tacttttcat actctctttg ttcagtaaat gtcttgttaa 2907121 attcgagaat atcatttaga agactcatgt tcgttgtccc tttctattct ttttactctt 2907181 caatatatca caacccttgt ttattcgtca taataaaaaa agacaaaccc tcaggcctgc 2907241 cttatttccc catgttatag cgttttttga actgctcaac tcgtccgcct ttttcattga 2907301 atttctggcg gcctgtataa aacggatgcg tgtcagagct tacctctact ttaatgacag 2907361 gatatgtgtt tccgtcctcc cactctgctg tttcattaga tgttttcgta gaggtgctta 2907421 gaaaacggta gccgctgttg acatcctgaa atatcacttt gtggttcttt ggatgaattc 2907481 cttctttcat gggtatctcc tttcaataaa tcgtaataat tacgttttat tttataacct 2907541 tacaaacgtt ttgtcaatct tcttatatcc ttccctctgt ttcacatcgt aaacctcatg 2907601 gcatttaaga ataggaagaa taatctaacc gaggaagcaa ataataaacc caaaatacat 2907661 acagaacgtc tttttggaaa ggtggtttac gattgtggat gatttagttt tggccagaag 2907721 cctttttggc acgacgatgg gctttcatat cattttcgca acacttggag tcggtctgcc 2907781 gctcatgatt ttagtggcgg aattgatcta tcaaaaaacg aaagatgacc attatgcgat 2907841 catggcgaaa agatggacga aagcacaagc cgttttgctg ggggtcgcca taccgaccgg 2907901 aacgatcgcg ggcactcagc tcgcgctttt atggccggga tttatggaag tcatcggccg 2907961 ggtgatgtcc ctgccatttc aaattgaaat ctatgctttt tttgttgaag ccctattcat 2908021 gtcgatttat gtatacgctg cagaccgttt gtcacctgca atgaggattg ttgctgtttt 2908081 ctttgtgtta gtcggggcag cagcatccgc tgttctgatc acgaatgttc acgcttttga 2908141 aggtacgccc gccggtttta aaattttaaa cggaaaaatt acagatgttg acccgtgggc 2908201 tgcgtttttt aatcctagct tttttatcac tgccggccat gtcgtgctgt ccgcgtttat 2908261 gactggtgcg tttatcgtgg cttctgttgc ggcgtataaa atgatccgaa cgaggaaaaa 2908321 ggaaagggtc tatcgctttc accggaaagc ccttttgctc gcactgacga tcggcggtat 2908381 tttttcattg ctgaccgctt tgaacggaca cgaatctgca cagatgctgt acgaatacca 2908441 gcccgaaaaa ttagccggtg cggaaggcct atttgaaaca agatcccacg ccccgctcgc 2908501 tatcggcggt tttaccgacc cgaatgaaga aaaagtaaaa tgggcaatcg agattccatg 2908561 ggctttaagc tttttggcag cgaaccgttt tgacactgtt gtaaaaggat taaatgcatt 2908621 tccgagagat gaatggccgc cgcttttcat tcacacgctg tttaatgcga tggttggtgt 2908681 aggcatgctg ctaattcttt attccattat cggtgtggtc tggagaaagg tgctcaagaa 2908741 agaccgtttc ccaacgtggc ttttgatcat tttcatgaca gcaggccctt ttagtctcat 2908801 cggcattgaa ttcggctgga ttttcgcatg tacggggagg cagccttggg tcatctatca 2908861 tctgctgaaa acgtcagatg tcgtaacaac gactggctcg atcggggtgc tgttcttatt 2908921 tttcacattt gtttatgccg tgttaggcgc agctgtcgtc tacgtgctgc tgtattattt 2908981 ccgcaagcac ccggttgacg aagatttaaa tacagcggag tcgtaatggc tccgcaaaca 2909041 ggaaaccaaa tggaaggaag atcgtacaaa tggagatttc aactgacgct ctgatcgcca 2909101 tctcaattat ctggggcttt gtgtttattt acgccgtcat ggcgacaatg gattttggag 2909161 cgggattttg gtctatgatc tatttaaaca aggagcatat gaaggccacc gatattgcga 2909221 atcgcttttt gtccccgact tgggaggtca caaacgtctt tattgtggcc atcgtcgtgg 2909281 cgcttttcag ttttttcccc ggcgcgacat ttgtgctcgg caccgtttta ttaattcccg 2909341 gaagcatgat tttgctgctt ttagcaattc gaagcggatt tctcgtgttt tcaaatacag 2909401 caaaggagcg gaaaacgcta agatatattt ccggcatctc cggctttatc attcctgcta 2909461 ttttaatttt ggtgcttcct gtgacacacg gagggtttat agaaaaaacg gatggaatct 2909521 ataacttaaa tatgtctaaa atcttttcaa gccccaacgc ctattcattt atcgggtttg 2909581 cgattttaag caccttattt ttgtcctcgc tgttgcttgc agatttttca aatgtggcag 2909641 aggaacagga tgcgtaccga gcctacagaa aaagcgccct gattaccggc ccgatttcac 2909701 tgttgtttgc tgtatgcatt atggtaacta tgcggaatga agcaaactgg ctgtacagcg 2909761 gaatgatgaa tgatttttct tggattattg catcgttcat tacatttgtc attgctggaa 2909821 tcgctctttt tctgcctaac aaaagctttg gtcaaaacat cggaaaaccg cgtctcgcac 2909881 ttgttgcgat tgggatacag tattttctcg caagctacgc gtacgggcgg gcgcatcttc 2909941 cgtatatgat ttatcccgat gtgacagtca tgtcaggctt cacagagcca gcaacgttca 2910001 gagcgctgtt tgcaacgtat atcgttgcat ttatcattct atttccgggc ttctttttct 2910061 tctggaaaat gtttatgcga gataaacgct atatccgcca ggaggaatag agggcaagcc 2910121 agccggctat actaatccag aacctttata aggaggggat ggcatggagc agaaaattct 2910181 atgtgaggtc aacaactgtt cttattgggg caaaggtaac aaatgcaccg ctgatgccat 2910241 ttatgttgtc agccatactg gtgaaacggc tgaaaacagc cgggaaacag actgcaaaac 2910301 gtttaagccg catgatttat aattaaaaga aagagctgca tcagccagct ctttcttttt 2910361 gcatgttgag tgttctcagc tttttagtta tgaccccgtt tgcaggtgaa aacaaaaagg 2910421 cgcttgcata acatacacct gtcatggccg ccatcgctcc tgaaatcgaa acattaagcc 2910481 acgttgcgaa gaaatagccc atgaccgccg acagcccgcc aatcaacgcg ctgagaatca 2910541 gcatataaag aagccggtct gtcagcaaat gtgccgcagc cggcggaaca atcagcatgg 2910601 ccacaaccaa tacggcaccc accgaatcaa aggaagcaac agtcgtcaag gacagcatgc 2910661 ccatttgcac gtaatgaatg agcaaaaccg gtattcccaa ggctaaagcc atttgaggat 2910721 caaacgaagc gattttaaac tccttatagc acacactgat caacactacg tttaaaacca 2910781 gaacagatgc cagcatccaa aacgctttcg gcccaatatc aaccccgaat accgtcaccg 2910841 tattccacgg cacaaaagcg atttctccca ttaacgagtg ctcaatatcg agatggacat 2910901 tcgctccata cacagaaagc aaaataaccc cgattgcaaa taaggatgta aacacaactc 2910961 ctatggcagc atctgattga acccccttgc tatgaagaag ctgaaccaag aaagccgtta 2911021 acagaccggt tgcggctgcg ccaataaaca tataaatccc atcgagactt cccgtcacta 2911081 gaaaagcgcc gacaatgcca agcaacactg tgtgactgat tgcgtcggcc agcatcgcca 2911141 tgcttctcag cacaagaaat gtgccgatca atccgcagct tacaccgact aatacaccgg 2911201 tagctataat ccatgcttca aaactcattt gcgatctgtc ccttctcggc atcatgagac 2911261 gcttttcgac gctcaggcat ccgtccatac agctttaaga gtgaataaag ccgctctctc 2911321 gtttctctcg gtaaacggtc cgggtcaaag tagtcctgat cggattctat attggcaagt 2911381 tccatttcat gcatgagata cacttcatac atccgctgct tcaaagctgt gtgatagcct 2911441 ttttctatcc ctttgcttgt gatttgccaa atcccatttt cgatacgctc aatgcacctc 2911501 tcttgttcca agtcatttaa tgccttaagg cataatgaag gggataggcg tcttttcttt 2911561 cttacacttt caacagttac acaaagatta ttcttttcat actgttcata aatcgccaaa 2911621 agcacttgct ccctgcttgt tctgcgccgc agcctcatca gccttatggc tttagcagcc 2911681 aatccccgct taggcgcgca aatcattgaa aaaagaaaga gcagcgttgc agataagatc 2911741 attaatggcc ctgtcgccat tcccttcatc gtggtgctaa gcagggttcc ggccactccg 2911801 ctgaccccgc ctgtaatccc ggcaatgatg atcatcccgg ttaatcgttc ggtccaatat 2911861 ctcgcggtta tggcaggtgt aatcagcata gccgccatta atatcacacc aacagtctga 2911921 agcccaatga cgacagcaca gacaatcaga caagccaaaa gcccgtttaa aaaacgcacc 2911981 gggattccta atccctttgc aaacgcgaga tcaaaagtaa tcaatgtaaa ttccttaaag 2912041 aaaacaatac ataggagcag tagaacagcg gatatccctg caataaggat gatatcctgc 2912101 ctgaccaatg aagcagcctg gccgaataaa aaagaatcaa gcccgctttg gcttcccgcc 2912161 ccctgttgct gaatatatgt cagcagaatg atcccgacgc caaaaaacac agaaagaaca 2912221 atcccgatcg ccgagtcctc ctttgttttt gaaagccgag gaatcagctg aatacaaaac 2912281 gttccgagca gtccggcgag cgctgccccc agcaaaaaga aaggcagtga tttttgcccg 2912341 gtgaacagaa aagcgagaca cactcccggc agagctgaat gggccatcgc atcgccgatt 2912401 aaactttgct ttctcagcag cacaaagctg cccaaaacac cgcttgccgt cccgagcaaa 2912461 agcgtaccgg ccagcaccca ctgtgtattc ggatgctgaa gctgcagcca caaactttca 2912521 aacattgcgc tcactcctta tgtccttctg ccagcacttt atcttttaaa aacgtaagcc 2912581 ttcctccata tgttttttgc aggttttcga tcgtaaaaac gttttccgtc ggtccgaaag 2912641 cgattttcct taaatgaagc agtaagatcc aatcgaaata atcctcggcg gtctgcagat 2912701 catgatggac gacaagcacg gtttttcctt tttctttgag ttctgccaac agcgtcataa 2912761 tcgcgcgctc cgtcgctgca tcaacacctg caaacggttc atccataaaa taaatgtcag 2912821 cgttctggca gagtgcccgg gcaagaaaca cccgctgctg ctgtccgcct gacagctggc 2912881 tgatttgcct tttcgcataa tcatgcatcc cgacttttgt taatgcggcc ttcgccatct 2912941 ccacatccgc tttctttggc ctctttaata aaccgattct cccgtatctt cccattagga 2913001 cgacatcgag cgggcttgtg gggaaatccc agtcaaccga gccgcgctgc ggaacatatc 2913061 cgattctggt ccgctgatcc ttatagtctt tgccgtaaat agagatgtct ccggaagctc 2913121 tgggcacaag accgagaatc gttttgatca aggttgattt tcccgcgccg tttgggccga 2913181 taatgccaat aagttttcct tcaggcacct gcagcgaaat gtcctgcagt acaggctttt 2913241 tatgataagc aaccgtcaca ttatcaagct caacagggaa catatcctcc acctcttttc 2913301 tttatttaag cgctttagta atcgtgttga tattgtggcg gaacattcct tcgtatgtgc 2913361 cttcttttgt gcccttttca cccatggcat ccgaataaag ctgaccgccg attgtgactg 2913421 tatggccttt ttctttagcg ccttccacca ctgcattgat tgatttttca gatacactgc 2913481 tttctacgaa cacagctttt atttgttttt ctgtcagaag atcaaccagc tcctgaacat 2913541 cccttaatcc atagtccgaa tctgtgctga gtccctgcag gccttttacc ttaaatccat 2913601 actcattccc aaagtacgca aacgcatcat gagcagtcac aagcacacgg cttttctccg 2913661 gaatatgtgc gatctcctta cgcgaccact tatctaaata ttgcaaatct tctttgtact 2913721 ctttggcatt tttccgaaag gcatctgcgt gctgaggcat tgctttgctg aattgcgctt 2913781 caatttcatc caccgcatag atccataacg gaatgctgaa ccagacgtgg ggatcaaacg 2913841 tcttgccttc ccccgcggga ataagcttat ttttcggaat ggcctcagct actgccgccg 2913901 attgtttttg ttcgccgatt ttttggagga catcctccat tttcccttcc aaatgcaacc 2913961 cgctgtacag aacaacatcg gcagacatta attttttcgt gtcaccttgg gaagctttgt 2914021 aaaggtgcgg atcaaccccc ggtcccatta aagaggtgac ttttacgtgc ttacctccga 2914081 tgttttctgc tgcatcggca atttgagatg ttgtcgctgt cacttgtaat tgctgatcag 2914141 cgctttttcc ggctgaatcc gttccgcatc ccgttaaagc aaaggtcgca aaaagtactg 2914201 ctgccatcag cccttgtctc atatttctcc tcctctttgc catcaatgtc cgattgtttt 2914261 atcttatgtt gtcagttctt agacatgtga cattaaatta gccaaaagca tgttttattt 2914321 acacaggaca aaaagtttcc ctcatgcaaa attatcgcgt ttggccattt ttgtcaagct 2914381 gatttacata aaaaaaccgg ctgggtcagc agccggtcca aacgagaagg gatgtattca 2914441 acgaacactt ttactgtaac agcacagtgt catttattca aaatagcaaa atgctttttt 2914501 cttaaccatg ctgtgtgaaa acatccattt tggtcacata ttttcgcata atatcttggt 2914561 ttacctcaac ccctaaacca ggctgttttg acacagaaat aaatccatta tcaatacgaa 2914621 tatcaggagt tacaatatct tcatcccaat agcgtgagga tgaagatata tcgccaggta 2914681 ttgtgaattg aggcagtgaa gcaagcgcca cgttctgcgc tcttgatatg cctgtttcca 2914741 gcattcctcc gcaccaaacc tgcatatgat gctctttgca taaatcatga atttttaagg 2914801 cttctgttaa gccgccgaca cgagaaggtt ttatattaat aattttgcag cttcctagct 2914861 caatcgcccg tctcgcatca tcaactgaac aaatgctctc atcaaggcaa atggccgttt 2914921 tcaaatgttt ctgcaagtgg cggtggtcaa cgatatcgtc agcttggagc ggctgctcaa 2914981 tcatcattaa atgatagtca tcaagctcct ttaaacggct gatatccttc agttcgtaag 2915041 aggaattggc atcggccata agcgggatgg ttgggaatcg gctgcggatg gccttgacca 2915101 attccacatc ctgcccaggc tgaattttaa tttttattct ttgataacct tctttttgat 2915161 agctctcaat ttccttcagc atatcgtcaa gaggcgccag gccgactacc accccggcag 2915221 ggactttatc tcttgttccg cccaatgcct cagcaaggga tacgcccttc tttttggcat 2915281 aaatatccca tacagccgat tcaagtcccg cttttgccat ccggtttcct ttataccgcg 2915341 ccaggctgtc cggcacttct gaagggtgat tgaattcacg gccgacgaca tttgggataa 2915401 aaaaatcttt tagcatatgc aaacatgttc caatggtttc ctcggtgtac caaggcgaag 2915461 agaaagcgga aacttctccc cagcctgtga cacctgatgt atcaatggct tccacgatca 2915521 gaaatttacg ctcttgaagc gtttcgatac tgtttttaaa cggtttcttt aagttcatgc 2915581 tcaaatggta aagcgtgatt ttttctattt cgatcatagc agttctcctt tacgcgcatc 2915641 cttcagctga tttcgcaaga gcttattaga cgcattgcgc ggcaggcggt caagcacaaa 2915701 gaattttgcc ggaattttat acttcgccaa gcgttctttg cagtagtcag tcaattctcc 2915761 tgcgctcaca ggcttgtgaa ggacaagata ggcgtgaggc actttccccc attttttgtc 2915821 ctcagcccct gaaaccccgg cttcggccac agcggggtgt gaaagcagca ctgactccac 2915881 ttcggccgga taaatgtttt ctccgccgga tatgatcaga tctgaacgtc tgtctaatac 2915941 atataaaaag ccttcattgt ccaaataacc aagatcacct gttttcagcc agccattttg 2916001 aaaggaggct tcgtttgcgc tctcccggtt aaaatagctt ttcatgacat tcgggccttt 2916061 gaccatgatt tcaccgtgtt catacggttc acatacctgt ccgtcccgct ctattttgat 2916121 ttcacacgaa aacagcggtt tccccgcaga tccgagcttt tccatgctga attccggcga 2916181 cagggtaaca atttgcgagc atgtttctgt cattccatat gactgaaaga cagggaatcc 2916241 tttctcacgg cattcctcaa gcaatggcag cggtgcagga ccgccgccga gaagaatgca 2916301 tctgatggat tcagggcagc ggtttgtttc ttccaaaaga ctggccagca tagtctgcac 2916361 cgcagatatc attgtcactt catgcctgtt gatagaatgc agcacatcgc ttacggaaaa 2916421 acgctggtga agcacgacag tcattccata gatcacagat ttaaataatg cggacaatcc 2916481 gctgatatga aagagcggca atgcgataag ccagcggtct tgttctgtta tacccaaatt 2916541 aagagcggac gacaccgcac tgaaataatg gtttccgaac gtttgctgaa ctcccttggg 2916601 ctttcctgtc gtacccgacg tatacatcag cgttgccgtt gcatccattt gcatataagc 2916661 ctcgatctca atttcctctg ctgcttcttt catcagttca tccacatcaa tcgtttgaac 2916721 gatgtgttca tattctttct tctcaaagct tgaatctgtc aataaaaagc cggatcccga 2916781 atcctccagc tgaaacagcc tttcatgtgt tgacagcttc gtattcaaaa gcaccgcctt 2916841 aacaccaagc aaaaaacaag cgtgaacagc gtataccatt tctgcacggt tttggagcaa 2916901 aatagctgca gtatcccctt tccgaaccga atgagcggca agctgttccg ccattcgttt 2916961 agacgcggca aacaattctg caaatgtcac ggtttggtct tcatagatga gagcgattct 2917021 ctcaggtgtc agctgtgccc gctgcatgag ccagttgggc tgttctgtca gcatgtcatc 2917081 atctccgagg taaaatgtct gtattgaaaa gaaaacagct tggaccgcaa agtctcaagc 2917141 tgttggttta ctagatattg ctgatcacgg aaaacgaggg aactgtccga aatcaggttt 2917201 gcgtttttcc ttaaaggaat cacggccttc ttttgcttca tctgttgtgt agtaaagaag 2917261 ggtagcatcc cctgcaaact gctgaattcc agcaagtccg tctgtgtccg cgttaaacgc 2917321 agctttaaga aagcgcagtg cggtcgggct tttttcaagc atttcttcac accatttaat 2917381 cgtttcttct tcaagctgtt ccaaaggaac gactgtgttg acaagaccca tgtccagtgc 2917441 ttcctgtgcg ttgtactgac ggcataggta ccagatttca cgtgcttttt tatgtcctac 2917501 aattcgagcc aggtagccag aaccgtaacc tgcatcgaag cttcccactt tagggcctgt 2917561 ttgtccaaaa attgcgttgt ccgcagcaat tgtcaagtca catacgatgt gaagcacatg 2917621 gcctccgccg atcgcatatc cggacaccat cgcaacaacc ggtttcggga tgacgcggat 2917681 taaacgctga agatccaata cgttaagacg agggatctgg tcgtctccta catatccacc 2917741 gtggccgcgc actttttggt ctccgccaga acaaaatgct ttgtcccctg caccggcaag 2917801 cacgataacc ccaacgtttt ggtcgtctct tgcgtcagca aacgcatcaa tcatttcagc 2917861 aaccgtttta ggggtaaacg cattatgtac ctcaggtcgg ttgattgtta tttttgcaat 2917921 gccattatac gtttcataca atatctcatc gtatgtccgt tttgttttcc attcagccat 2917981 atgatgacct ccttttattc tctatgtgaa tgagtcagat gcttgtcaaa aactcactca 2918041 ctattttacc aaacaatcgc ggctgctcca catggaccgt atgtcctgct tttggaacaa 2918101 tctctattct actagaagga agcatcttat gcacctcttg attgatggcg caaaattttt 2918161 cgtcccactc cccgcagatc agaagcacag gaacatctat ttcctctaca cggctccaca 2918221 aggaaggctg tgaaccggtg cccatgccgg ttaaactgtt cgcaagccca atcttattgt 2918281 tccgcagacg gcccgatcgt atcctgtacc gaatatcttc agccagcctc tgctgagatg 2918341 aaaacaaagg gatattctcc caatacgcaa caaacgcttc gagcccgtct cgtaaaataa 2918401 aatcagcaag cttccggtcc cgcatgattc gttcccgccg ttccccaagt gttttgagcc 2918461 ccggcgtcgt gctttcaagc acaagtgccg atacccgctc gggatatgtc atcgcaaaag 2918521 agtaagcaag ccttcctccc atagaatacc caatcaattt cactttgtga agttttaatt 2918581 gatcaaaaat ctcggcaagg tcagaaactt gccgggttgt gctgtatctt ttcccattca 2918641 gcggggcatc ggtttcccca tgccctaaac aatcaatttt gatcaaacgg gaatcaggca 2918701 gcatttcatc aagaaaagtc catgattgtt tgctgccggt aaacccatgc agacagacga 2918761 cggcttcgga agcattcggt ccctcgtctg ccactgcata tcggacacca tctgataccg 2918821 ttatgtttac agttcccatt gttttttcac ttcccgcaca gcctcattca gcatatcgcg 2918881 atgaagctgg actcttgatt ggcgatccgt tttgatttca atcaaatgga gtccgggctt 2918941 gtctgcctgc ggcgcgtaag ctgttttgaa ttcatcccaa gaagccgggc atgaatacgt 2919001 tccgccgtaa agtgcagccg catgcttgaa atcgagccct gtcggtgtgc cgaacaaatc 2919061 ttcaaagtgt gtcttctcag aagcctgcgg caaaaaggag aaaatccctc ctccgtcatt 2919121 attgacaaga atcacagtaa gaggaatacc cagctttttg gccgccagca ggccgtttaa 2919181 atcatgataa aaagataaat ctccaatcac aagggtaaca ggcgcttttg ttccttcaca 2919241 tacccccatg gcagaggaga cgacaccgtc tatcccgttt gctccccggt ttgaataaat 2919301 ccggaaaggg cggtcctgct tttcaaaaaa cgtatcaaca tccctgatcg gcatgctgtt 2919361 tcccacaaac agcgagctgt tttcaggcac aagatgctga aggattcgat agagattgcc 2919421 ttcaaacgaa acatcttcac tgctgattgt ttgcagatgc tcgcggaacc gcccattgac 2919481 aaactgccac ttttccagcc actctgagga tctggtggca gcagtaaggc ctgccatgat 2919541 ctcctcagca aaaacagacg cattacaatg aatcatatgc gcgcttgcct gtgtcgggtc 2919601 tctccaccct ccatcctcgt caatcacgat ttgctgaatc gtcggatcat ccttaagcca 2919661 taagaaaacc ggttttgaaa caggcatcgg tccaaaccga atgacaacat caggacggag 2919721 tttccgcttc agctcatcat cttttaaaaa cgaatcatac gcatcaataa cagtgctttt 2919781 atcatgaaca ccattccgca gattagacag cggatctgct aaaattggat actgaagcgc 2919841 ttttgacagc gcaataatgt tttccttgtc cgcatcacta tggagctctc cgcagacgat 2919901 cattcctttt tcagcctctg cgagcatctc agccacatca gacagggact ctcggtcaac 2919961 agactgcgta cccgttttca cagacacatg acggcctgtt ctcattcttc caaacggctc 2920021 atctgaaaga tccggcatca gcggttcgcg cagcggcaca ttcacatgga caggccccat 2920081 cgggcgcttt tgtgcttctc cggcagcgcg gcttgccagc gttcggatgt atctcagcat 2920141 ttgcggagac tcttcaggaa gagcagagtc tgtgaaaaac ttaacaaagt taccgaataa 2920201 gaagtgctga ttaatagcct gcggtgcgcc tacttcgcgc agctcatgag gccgatcagc 2920261 agttaacaca ataataggca cccttgaata atgggcttca accacagccg gataaaagtt 2920321 ggccgcggct gttccagatg tacagatcaa tagtacggga cgctgcttcg cttttgccaa 2920381 acctaatgca aaaaatccgg cagacctttc atcaatttgg acatggacgc tgatatcggg 2920441 atgcgcagca caaagaacag ccagcggtgt agatcttgag cccggacaaa cgacggcgtc 2920501 cgtaattccg gaaagggcga attcatcaat aaaacttccg atgtaatgag taatcgggtt 2920561 gactgtcaac gcctctcacc tcctaatgca gagatcatcg gcttcaattt aatctgtgtt 2920621 tcttcatatt ccgagattgg ttccgagtct tccacaatac cgcacccggc aaacagcctt 2920681 gctgtgcttc cttcgatgag ccctgaacga atggcgaccg cgaattcccc gttatcctgg 2920741 ctgtcaatcc agccgatagg ggccgcatac cagccgcggg acatcggttc aatctccctg 2920801 atcacgtcaa cagctttttc ctgaggtgat cccccaagcg cgggagtggg gtgcagcttc 2920861 tcaattaagt caaaaatcga agcagactcg cgcagctgtc cgacaatcgg cgtaaacagg 2920921 tgctgaacgc tttttgtttt gtacaaaaca ggtccatcag gcttttcaac ctctgaacag 2920981 cttgatacaa aagcattatg aatcatacct accacaatat catgctcaag caggtttttc 2921041 tcatcgttta ataattcaag gcctatccgg cggtcgtctt cttcattcac gcctcgttta 2921101 atggagcctg ccagacagga agacatgaca gtgccgccgt ctcttttgat cagtctttcc 2921161 ggagacgcgc cgacaaaggt tttgccttct tgttcaattg caaaaacata gcttgtctgc 2921221 tgatcgtcca gaagcgtttt aagcaccggt tcaatttgga ttggaccgtc aaacgtgagc 2921281 agcagctctc gggcaagaac aaccttatca tattgtttct ctttaatttg gcttgtggcc 2921341 gtttcgattg ctttcagcca atcatcctta tccagctctt cggctgctgc aatcacagcc 2921401 tgatcttctt gcttgaaatc gggaaccata aattccgccg caaaagcttt taagccttct 2921461 aaaacagctt ctgcgtcttc tcctccgctt acccatctgt taactgttaa gaacgggcct 2921521 tcagcagtca tcgtcagcat aagcgcaggc acaaagaaat ccccttccga gaaatggtcc 2921581 cattgtgaac ctctttcttc gcaagggtca aaagaaaatc ctccgaataa cacaggtccc 2921641 actgcagaat gctgcagctt ttcttcttca taaatatgaa aagccgtctt tttaaagcgc 2921701 tcccattgtt caaaaacctc acgataccgc tcgctgtttt tttgatttgt ctggaaaacc 2921761 gcttctttgc caagaccgac tattgtcaat tcactttcag gatctgacca aaaaaatcga 2921821 ttgcctgtat atttttttgc tccgtaattg aaaaatgata gagggtcaag agactcgatt 2921881 tgtctcgaat agcttattaa gacagcatgg ttgacttctt tggctttatg taatgcatgt 2921941 agaacttcct ttcggaacgt acgctgcacc gttgtcacca tgagacattc ctccataatc 2922001 cttaaaatgc ttttaatacc atacacctgt gtctcctttg tgtcaaacac agatcatgca 2922061 gtccaaatgg cctgccttac ctattataaa cctaatttca gaaatgaaaa agaaacaaag 2922121 cttaaatttc tttctccact gatagcaaag gttgtatccg cttaccataa aaggaaaacc 2922181 tcctatattc ctccacccgc catttatgaa agttctcagg cgatctgttc atactaaagg 2922241 tatgcatcac agagaaacga ggcgatcaca ttgcttacga aagaacagct tcagcattta 2922301 aaaaatgaac tggaacaaac gaaaaaagat atcttaaacc gtttcaaaga caatgatcat 2922361 tttcagctta actcagcctt tccttatgat tcgtggggtg agctttcggc atacgacaac 2922421 catcccggcg atcaggcgac agaactttac gagcgtgaga aagacatcgc tctagacttg 2922481 catgagagag agcaccttcg ggacattgag cattcattga aggcgataga aaacggtacg 2922541 tatggcattt gtgaagtcag cggaaaggaa atccctttcg aacgacttga agcgcttccg 2922601 actgccacaa ccctcgcgga gtattcgtca caggacgtgg tttccaaaga ccgtccgatt 2922661 gaagaagaaa caccattcgg gcaatttgaa tttgatgatg atgaagaaat cagagcgcca 2922721 tatgacagtg aggattccta tcaggatgtc gaaaaatatg ggaactcaca aacgccgcag 2922781 gatatggaaa accctccgct cagctatgat gatatgacga tgaatgccga agagaatatc 2922841 ggcaatacgg agtcttacga aaatttcatc gctacagata tcactgggaa agaaattacc 2922901 gtttatcaaa gcagagccca tgagcgctat gaagaagaac ttgacgaaga gggaatcatg 2922961 accacattcg gcgatctcca cgctgattga acccccaatt attgggggtt cttttccgtt 2923021 ttcagcatat cgtaaatcag cttcagataa tccttttgca ggccgatgtc ataccgctcg 2923081 ccctctagca atttcccgta tacggtacat gccccgagcg aagcttttat cgcatccgtt 2923141 acctgcactt ctcctccgct atcagcttct aatgcctcca gctcattaaa aatatccggt 2923201 gtgaaaatat aacgccctgc tgcggcaaaa tgagacggag ggttttgttt aggcttttcc 2923261 acaatatcct gtatgcgata aagccctttt tcaacaggct ccccttttat caccccgtaa 2923321 tgatgtaaat cctccgtttt tgtttctttt aagccgatca cactggactg atatttcgta 2923381 tacgcttcaa tcagctgccc caaagccggc tgattggcgg aaaaaatcag atcatctggc 2923441 aaaacgacgg caaaaggctc tcctcctgca aattgctttc cgaaagaaat ggcgtcgcca 2923501 agaccctttg cataaggctg ccgcacatag tgaatccgta tatccggaat gggatgctct 2923561 ctaagtaaat gcagtttatt cttagaggcc aaaaaagcct caagtgccaa agaggaatca 2923621 aaatagtcga caatcagatt tttatggctc gatacaacca tcaaaatgtc ctcaatgcct 2923681 gactccttta attcttcaac aagataatga atcacaggct tagatcctac cggaaacatt 2923741 tctttcggaa tcaccttcgt caccggcaga tttctcgtgc cgaatccgcc tgcaggaatg 2923801 atcgcttttt ttatcatggt attttcccct cagctcatgt ttattacatg atattccaag 2923861 agcgcatccc gatgtttgta catctgaaat taggcggaag caactgggca gaaagcggaa 2923921 tcacgaacca gccctttttt aataggatat tgatatatga ccagtaatct tgtaaaggag 2923981 ctcaggtgat gaaaatttgt gtggttggcg ccgggtatgt cggtttaacc ctatcagcgg 2924041 cactggcatc catcggacat gacatgatat gcacagacaa agacgtcaaa aaaatcgggc 2924101 agctgaaaaa aggagtcatt cccttttacg agcctgggct ttcagatgca atacttcgtt 2924161 gcggcaatct ctcgttttct tctgaagtga aatcgagcat ggaggaatgt cccgttattt 2924221 ttatcgcagt cggaactccg ccgcgttcgg acggatcagc tgatacgaaa gccctgcagt 2924281 ccgtcatcgg tgatttaagc gaggcgatcc gatcgtataa aaccattatt acgaaaagca 2924341 ctgttccgcc cgggacaaat gaaaacatag caaaacagct gattgcctcc ggagtgtcta 2924401 aaaacctctt taatatcgta tccaatccgg agtttctgcg ggaaggcaat gccttatatg 2924461 acatgctgca tcctgacaaa acagtcatcg gtgttcagga agaagatcac gtatcggcag 2924521 ccatcgtcaa atccatttac aaacacattg ataccccttt tatcgttaca agcttagcgg 2924581 gagcagagct gatcaaatat gccaacaatt tctttttagc ggccaaaatt tcgttcatta 2924641 acgaaatggc ccgcatatgt gaagcctatc aatcagatat ctcagatatt tcccgcgcta 2924701 tcggtctaga cccaaggatc gggaagcact ttttgcaggc aggcatcgga tacggaggct 2924761 cttgttttcc aaaggatctg caggcgctgc aatttgctgc ccaggaaaaa aacacggaga 2924821 ccttcctgct ccgggccgtg cagcacatta atgacaccca gcttggcctg tatatcaaaa 2924881 aaatacagtc attcttcgaa acacttcaag gcaagaaagc ggctgtactc ggcatttcct 2924941 tcaaaccgaa tactgatgac atccggaatt ctcaggctgt cagactgatg gaaaggctgg 2925001 cggagctggg atgtgatgtt catgcatatg atcctgaagc tgtacttcca gaacatttgc 2925061 ggcaacatgt aactcagcat tctcaagctt ttgatgcgat cgaagagagt gactttttat 2925121 ttttggcgac agaatggtct gagtttttag cgtttgattg gaaaaaggct gcagatatca 2925181 tgaaagggcg tcttgtgatt gacggacgca acgtactaaa aaaagaactg atcgaggctt 2925241 gcggcctgat ctgtacggga gttggccgtc catgaaaata ctcgtcacag gagcagcggg 2925301 ctttatcggc tcccacctct gcgaagaatt actaaaagat aagaaacata acgttatcgg 2925361 aatcgatgac tttatcggtc ctactccatt ttccttgaaa ttaaaaaacc ttaaaaacct 2925421 gctgccggaa aagcgattta cgttcataaa ggaaaatctg ctgacagccg atcttgcttc 2925481 cttactggaa ggagtggacg tcatctttca tttggcggcc ataccgggtg tccgctcaag 2925541 ctggggcaat cattttcacc catatgccgc acataatatc caagcgctcc aaaggctcct 2925601 cgaggcgtgc cgggaacatt ctattcaaac gttcgtcttt gcatccacct cttccgtcta 2925661 tggcgaaaaa caaggaaaag tcagcgaaaa cacgtcgctt tctcctttat ctccgtacgg 2925721 ggtaacaaag cttacgggag aaaagctttg ccatgtgtat aaacagagct ttggcattcc 2925781 aattgtgatt ctccgttttt ttaccgtata cgggccaaga cagcggccgg atatggcttt 2925841 tcaccggctc attaagcagc accttcagca aaagccgctt accatcttcg gtgatgggca 2925901 gcagtcaaga gatttcactt atatcagcga ctgtgtcaaa ggcatcaccg ctgttcttgg 2925961 gaaaccccac cttattggtg aaacagtaaa tatcggcggc gcagagcgtg cctcagtctt 2926021 aaaagttgtc tccctcattg aggatatttc cgggagaaaa gcaacactgc acttttcgga 2926081 caaaatagca ggggaaccga gcaacacgtg ggcggatatt tcaaaagcaa aacagctctt 2926141 gcattatgat cccgccacat ccttaaagga tggcttgacc aacgaaatcg cctatttatc 2926201 gtcgctgtat cagggggaat aaaaatgaag cttgccttta tctgtacaga aaagctgccg 2926261 gcgcccgcag tacgcggcgg cgctattcaa atgatgattg acggtgtcac gccctatttc 2926321 agcagcaggt acgacctgac cattttttca atagaagatc catcgctccc aaaaagagaa 2926381 acaaaagacg gcgtacatta tatccatctg ccaaaagaac attaccgcga ggcggtagcc 2926441 gaagagctgc gagcctcttc ctttgacctc attcatgtgt tcaacaggcc tttaaatgtc 2926501 tctttatata aaaaagcctc accaaacagc aagatcgttc tgagcctgca taacgaaatg 2926561 ttttctgaaa aaaagatgac cttcgcgcaa ggaaaagaag tactcgacaa tgtctccatg 2926621 atcacaacag tgagcgaatt tattaaacaa accgtcattg aacgtttccc tgaagccgag 2926681 gacatcacaa aagttgtgta ttccggcgtt gatttaaact cttatccgcc cgtctggacg 2926741 atgaaaggct cggctgtcag aaaaacatac cggaaaaaat acggtattga agataaaaaa 2926801 gttattttat tcgccggccg cttaagcccg acaaaagggc ctcaccttct cattcacagc 2926861 atgagacgga ttttgcagca gcaccctgat gctgtactgg tcatagcagg cgggaagtgg 2926921 ttcagcgatg acagcgaaaa ccaatatgtc acctatctgc gcacgctggc gctgccatac 2926981 agagaccaca taatctttac aaaattcatt cccgcagacg atatcccaaa cctttttctg 2927041 atggcagatg tatttgtgtg cagctctcag tggaacgaac ccctcgcccg tgtgaattat 2927101 gaagcaatgg cggccggcac gcccttaatt accacaaacc ggggcggaaa cggtgaagtc 2927161 gtaaaacacg aagtcaccgg ccttgtcatc gatagctaca acaaaccttc ttcatttgca 2927221 aaagcaattg acagagcctt tacagatcaa gaattaatga acaaaatgac aaaaaacgcc 2927281 cgaaagcatg tagaagcttt atttaccttt acccatgctg ccaaaaggct caatactgtt 2927341 taccaatccg ttctgacccc gaaaaacaaa caatttccgc cgccttttct gacgcaaaat 2927401 tttgatttat catctatcaa tcagcttttt gtgaaagcaa aaacataaaa cctacagctc 2927461 gtgttgcaaa acgggctgtt ttttcgctac agagaactta aaaaaaggca taaatgtgac 2927521 tttatgcctt gcgctttaca gtttgagaaa accatggagc tggtttagat tcacttggaa 2927581 gaatgatgat ttccacttta gcttcttccg ctaagtctgg ttcttcatct tcatcctctt 2927641 cttcatatgg gggcgctgag cgtttcgaat cacgctcctc ctcaggctcc agagtggttt 2927701 cgaattttgt ttcttcttca tcatcgacga ttttgcgatc tgtttccttt tccttcgttt 2927761 ctttttgata ttctttcggt gcattgatgt gagggagctc tcgaatgctg cccacatcta 2927821 aatgcttctc ctcttcttcc ttctcagctg agattgagtc atgagcctgc catcccatcg 2927881 gtccaggcgg tgtaaatacg aattggtcga gatccagttt agaaatagag gctttttgtc 2927941 tcgatgacct catgtcaatt cgcctcccga tacgctttta tctttttata cagttccggc 2928001 agtttatcca aaaacgaatc tttagattct tcaacagaaa tcatgttttg cagcgcccag 2928061 ttatacttct catctgacca cgttttcttt tgcttcaaat aatatttgtg cccgattgca 2928121 cagaacaaat gcggaaacgc gagatcaatc caaagtacct cgtactgttt ttctgtgagc 2928181 ggatacactg cgtcgtaggc cgcaagcagt gcaaccatga aatcagtatc ccatacagaa 2928241 agcttaacca tcactttatt cagcagaata cgaaggtctc ttgacggcaa atcgtaggta 2928301 atcgagtgaa gctcctttaa aaaaggctcc ccttcgatct cagtcaaacg tgccaatgta 2928361 aaatcctgaa aacagaatcc gccatgctcg agtgtctctt ttgtccaggt ttcgtattct 2928421 gagtcatcaa gcgctctgag agcttctttt cctcttgcca gcattttatc agcatgtttt 2928481 aagaaagttt gcgaaaatac gtcatcagga taggatgctg cgatctgcat attcccttca 2928541 agttcctgca gcttccaacg gtacaatttg tgccattttc ccagcctgct tctcttcttg 2928601 ctttcatctg tgcaaacata tccttttgag gcatgatgaa aatggccggc aaatgacatg 2928661 acttttttca tttgctctgc atcatagtaa atcatttctt ttcctgtcac tttgtcatat 2928721 aaactgtaag aaacctgatc cgtgcccaag cagctaccgc cattttttgt ttgatgaatc 2928781 ggcgctatcg gcagcccttt ctcttgtaaa tgggcgtgtg cctgagtgat aaaaagcatc 2928841 cgctccggtt tcatttgcgc ttcttttagc agctttgggc catgatcagt ttcgacttcc 2928901 cagattttgc gcccgctttt gttcgatttc agcgccacat ggtcgatatg aaacggataa 2928961 taactgagaa tttcggacac aatctgttct tcatgctctt tttggtacac tctgttcacc 2929021 ccttctatct gttcttttca tagacgctga gcagattttc agccaccctc tgccagccaa 2929081 aattgctttc tgcctcacgg cggctgtatt tcccaagccg ttcccgcttt tccgagctgc 2929141 tcagcaaatc attgatacgt tcggcatatt gtttaggatt ttcaaagtca tgaatgatgt 2929201 agccgttttt cccttcctct atgacctctg gattgcctcc ccgattgctt gtaataatag 2929261 gaagtcccgc agccatcgct tcataatgca cccttgctaa aggctcctgc cattgcgaag 2929321 agcatacaaa tacatctgac atggtataaa ggcgcggaat gtcctttggc ttcacaaatt 2929381 gaataaatgt gacatgatcc ttttgcatcg caccaagggt atgaagatgt ttgacatagt 2929441 tatttaattc attatctccg aaccattttg acccgataaa caccatcatg acatcggggt 2929501 gctcctcaat gatgtccggc aaagcctgca ataatatgtg cgggcctttg actttgctaa 2929561 gccggccgac aaacaagacg atttttttgc cgtgaagccc cagctcgctt cgcatctctt 2929621 cgcgagctcg ctgcccttca ttcgtccagc gagggtggta cgtttttaaa tccacaccag 2929681 aatacaccgt ttttgttttt gatcgtgctg acggaaaacg gcttgtgatc gtctgtccga 2929741 tataatcgct gaccgtaaca atctgcgcta cggagtcgat gcaaatctcg ccttccgcct 2929801 ggctgatttt atcgtaagcg aacatttcat tgtgaacgct taaaataaaa acagcatccg 2929861 gcgcctgttt cttcaatttc ggaacccagc ttgggcgatt acaaacatgc acaagatcaa 2929921 aacggctctt tttcagctct gctccaacgg cttcttcata acggtcttca tccaaatgca 2929981 cataatggac accgtctacc ttctctctat cagcgagatt cggatcttta atagaaaaca 2930041 cagtcacctc atgttttttt gcaattaaag gggcaaccgc ttcgaggtag atttgaatgg 2930101 cgcctcctcg aaccgatggg acaggaagct tctctgtggc gatcagtgct attttcatac 2930161 atagcctcca ttcctgcatg atttttaact agttagaatc atgatacggc tgaacaacca 2930221 acttgtgcgg aatgggactg ccctaaaaac aaaacgggta aacaaccaga ttcatctatt 2930281 aaatatagtc aaataactca atcatttttt ccttttgatt cataaggtag gagtaaaaca 2930341 ggtaaggatg tgtcctttaa tggcagaaaa ccatgaagtc attgaggagg ggaattcatc 2930401 agagcttcct ttatcagcag aagatgcaaa aaaattaacg gagctggctg aaaatgtgct 2930461 tcaaggatgg gatgtgcagg ctgaaaaaat agacgtcatt cagggaaacc agatggcgct 2930521 tgtctggaag gtccacacag actccggcgc ggtttgtcta aaacgaatac acaggccaga 2930581 aaagaaagcg ttgttttcca ttttcgcgca ggactattta gcaaaaaaag gcatgaatgt 2930641 tcctggcata ctcccaaaca aaaaaggcag cctatattct aagcacggct catttctatt 2930701 tgtcgtatat gactggatcg aaggaagacc gtttgagctg actgtaaagc aggacttgga 2930761 gtttatcatg aaaggccttg ctgattttca tacagcttcc gtcggatatc agccgccaaa 2930821 tggcgttccc atatttacca aattaggtcg ctggccgaat cactacacga aacgatgcaa 2930881 acagatggaa acgtggaagc tgatggcgga ggcggaaaaa gaagatcctt tctcacagct 2930941 ttatcttcag gagatagatg gctttattga agacgggctg cgcatcaaag accggctttt 2931001 gcaatcgacc tatgttccat ggactgaaca gctgaaaaaa agccctaacc tttgccacca 2931061 ggattacgga accgggaata cactcttagg agaaaatgaa cagatttggg tcatcgactt 2931121 agataccgta tcatttgatc tgcctattcg cgatttgcgc aaaatgatta ttccgctttt 2931181 ggatacgacg ggtgtttggg atgacgaaac atttaatgtc atgctgaacg catacgaatc 2931241 cagagcccca ttaactgaag aacaaaaaca agtcatgttt attgatatgc tgtttcctta 2931301 cgagctttac gatgtcattc gcgaaaaata cgtccgcaag tctgctttac cgaaggaaga 2931361 attagaatca gcttttgaat atgaacgcat taaagcaaac gcattgcggc agcttattta 2931421 agaccatcat ttcccccgca tatcgggggt ttgatattta taagataaag ggtaattaaa 2931481 tacatgcgga ggttgcaaat atgaaaaaga ttgtcggcgc tttagccgtt tttgtgatta 2931541 catatgcgct gttttcagcc gcaggctacc tgtttcctgt ggaccaagaa tggtacaatt 2931601 cattgaaaaa accggactgg acgccaagcg gaactgcgat cggcatcatt tgggccatcc 2931661 tgtttgccct gatctccctt tcagcagcca ttgtatatgc tgcgttttca tttaaaggtg 2931721 cgaaaagctt ttggtttaca cttttgataa attacgtgct caatcaagcc ttcagctatt 2931781 tccagtttac gcaaaaaaat ctgctggctg catcgcttga ctgcctgctt gtcgccatca 2931841 cagcaatcgt attactgatc attgccaaaa aatacagcag agccgcaagc tatcttcttt 2931901 tgccttattt tttatggagt gcatttgcga cgttcttatc ctttacaatc aattcaatga 2931961 atctgtgaac aaaaaaagcc gcttatacag cggctttttc acatcatcgg cttgatgccc 2932021 caaatgtcct tcgcatattc ccggatcgtg cggtcgctgg agaaatatcc agaatgagca 2932081 atgtttacaa tcgaatgctc agaccatttc cttcgctctc gataatcagc ttgaattcgc 2932141 tcctgtgcat ctgcatatga gctgaaatcc ttcagcacaa aatactcatc attatgcgga 2932201 agcagcgagt caaagatcga ttcaaattca tctgcctctc cttcaaaaaa accattgatc 2932261 aactgatccg ctacctgcct gattctcctg tcatgctgat aatattccct cgacctatag 2932321 ccgccgtttt cctgatacga tagaacctca tccgccttta agccgaacgt gtaaatacag 2932381 tcagggccca cccgctcaag gatctcgata tttgcgccgt catgcgtgcc gatcgtcaaa 2932441 gccccgttca tcataaactt catattccct gtaccagacg cttccttgct tgcggttgaa 2932501 atttgctcac ttacgtctga tgccggaaaa attcgctcag ccatagaaac tctataattt 2932561 tctaaaaaaa caactttgat cagctgtttg accgccggat cataattgac tttttctgcg 2932621 acagaatgga tcagcttaat gattttcttg gcataataat agcttggtga agcctttgcc 2932681 ccgaaaataa aggtttgcgg gtagattgaa aaccccgaat cctccttgag gcggttatac 2932741 aaatacataa tgtgaagaac attcagcagc tgccgtttat atgcatgaag ccgtttcacc 2932801 tgtacgtcga atatgctctc agggttcaca accaccccgg ccgtgcaaaa aatcaaatcg 2932861 gcaagctctt gttttttctt gcttttgttg ttttgaaact gttcaataaa tgcaggatca 2932921 gtggcgtacg gttctaaacg gatcagtgat tccggctgct tgacccattc atcgccgatc 2932981 gcctctgtaa tgatggcaga caagcctgga ttcgctttta acagccagcg cctgtgggca 2933041 attccattcg tcttattgtt aaaacgattc ggaaacagca agtgaaagtc gcgcatctcc 2933101 ctttccttta atatatcgga atgtattttt gcaacgccat ttacactgta gctgcctact 2933161 atggccagat gagccatttt gacaacacca tgcgctgtaa tcgccatgtt ctctatcctt 2933221 ttccagtctc caggatactt ttcccaaact gcacggcaaa acctctcatt gatctcttca 2933281 ataatcatgt acattcgcgg gagcagcggc ttaaacaaat gaatcggcca tttctcgagc 2933341 gcttctgaca atgttgtatg atttgtataa gaaatcgtat gtacagtgat atgccaagct 2933401 tcttcccagc tcatgttctc ttcatcgagc aaaatccgca ttagctcagg caccgcaagc 2933461 gcagggtgag tgtcattaat atgaatgctc acttttttat gcaggccgga taaagattta 2933521 tgtgttttac ggtaattgtt cacaatgctt tttaagcttg cgcatactaa aaaatactgc 2933581 tgcttcagcc gtaaaatttt cccctcatca tgggtgtcat cgggatataa gaattcagaa 2933641 accgcttctg tttctcgctt ataagacaaa atattaccgc cgtgataatg ggcatagggc 2933701 tcggcgttcc aaagccttaa cgtgttgaca gtgcccgttt catagccgat gatcgggata 2933761 tcataaggaa cagcggtaac aattgtcgct tgttcatggc gaaaatgcag gcgcccgctt 2933821 ttttctgtca tatggacttc gccccaaaac ggcacgtcca ctgcttgatc cgcattcctt 2933881 acttcccata cgttcccgtt tttcagccat tgctcaggca gctccacctg atgtccgtct 2933941 acaatttttt gctcaaacaa accatgctta taacgtatgc ccatgccgtg cccaggcagg 2934001 ttcaacgaag caagcgaatc taaaaagcaa gcggccaagc gcccaagtcc gccattgccg 2934061 agacctgcat cgttctctat ctgaaggatc tcctctaaat tgatgccgat ttcctttaaa 2934121 ccagcttcta caacatcacg aacaccaaga ttcattaagt tttgctcaag gagctgaccg 2934181 agcagaaatt cgattgataa ataatatgtc tgcttcccgg aatttgatct gcttttttca 2934241 ttcgtttcga tccaatcagc gctgatatac tctctgacca tattgcccaa cgttttatat 2934301 tgatccagct tggcagaatc tttaaagctt tttccgcacg tcatttccag acgctttaaa 2934361 aataagtctg caaagcgttc tttactcgag aacatcccgt ccactccttg tcacctgctc 2934421 gaaaatacgc tgatactctt tagccgactt cccccagctg taatctgcat tcatagcggt 2934481 cttcacgatg ctcttccata catcctgttg gcaataaaac gacagcgccc tttctatcgt 2934541 aaatttcaga tcatgcgcat taaaggcgga aaacgtaaag ccattgcccg ttccctcttc 2934601 ctcctgatag gcacggacag tgtcgtaaag accgcccgtt tccctgacaa tcggaatggc 2934661 gccatattga agagcaatga gctgccccaa accgcacggc tcaaatttcg acggcatcaa 2934721 aaacatatca gagcccgcat aaatttgatg ggctagcggc tcatcaaacc cgatataagc 2934781 ccggcacttc tcatgaaaag caaattctgc ataccggaaa taatcttcaa attcacgttc 2934841 tcctgtgcct agcacaacca gctgtatgtc ttgctcctca agaagttcgt gcataattct 2934901 gcggacaaga tcaagcccct tttgtttagt gagccttgtc accatactga tcagcggaat 2934961 atcgtttttc tctggaagcc ccatccgctg ctgaagcttc gttttgtttt ccagcttgca 2935021 tgcaagatcc cctgaatcgt attgcgcctc tatataaggg tcgcttttcg gctgatagaa 2935081 cgtatcatca atgccattta atatgccggt tacatcatct tccctatatt gcaaaacctg 2935141 ttccaactgc tcaccataat acggcgtcat gatttcattt ctgtaagtgg ggctcacagt 2935201 tgtcacatga tcagccgcaa tgatgcccgc tttcataaaa ttaacaaatc cgttgcattc 2935261 taacctttca taatgaaaat gatccatctc aagacccagc aagtcatgtg tgacatcagg 2935321 agggaatatg ccttgaaact gcaggttgtg gatcgtgagc acgcttttca tccgttcata 2935381 aaaaggatgt tttctgtact cctctttcag caaataattg accatcgctg tatgccaatc 2935441 gtgagtatga acaatatcgg cttgaacatt cacaactttg gcagcctcca gcacagctct 2935501 tgaaaaaaag gcaaaccgct caccgtcatc ataatgcccg tacaacgaat ccctgttgaa 2935561 atagtactca ttgtcgatga agtaataatt cacatcattc tctgccatat gttcaattcc 2935621 gcaatattgc tgccgccagc cgacagctac ggtacactca gcctgttttt tcatacgctt 2935681 tttccacggt tcaggtattt ggctgtactt cggcagcatc acagctacct cattgcctaa 2935741 tcgcgcaagc gcctttggca gagcacctgc tacatcggca agacctcctg atttcacaaa 2935801 tggggtgcat tctgacacag caaataatat cttcaagaat tcatcagctc tccttgcacc 2935861 aaaccttttc ttaatacaag cggctgctca gctgttcctg cagcttccgt cgccttgccg 2935921 attttaacat ccttatccga aatgacctgc tcaagaagac aatcctctcc aatctgcgtt 2935981 ttttgcataa taatgcagtt tttcagcttc gtaccctttc cgacatggac cgccctgaac 2936041 aaaatgcagt tttcaacctc tccttcaagc acacagccgt ttgccaccaa agaatttttg 2936101 acagtgctgt gctttccgta tttcgtaggc ggctcatcct tcacttttgt atagatcggc 2936161 tgctgcggca aaaacacctg ctgccaaaaa cgaggctgaa tgagctccat actgtgggta 2936221 taatattttt ccaccgaatc aatgacagcg gcataacctg aatattcata agggcaaatg 2936281 gtcagggcgg aagattcctt ttcaacagcc tcctgaatgg ttttatagcc tttttcgcta 2936341 tgtccgtaga tcagatcctt taaaagcgtt gttgacatga tatagatttg cagcgactgg 2936401 ccgtcctgaa atacctcggt gacgtcgcag ccaacctcct gatggcgttt cagcacatat 2936461 tgaaattgaa tgttgcatac ggtatggctg ttggagatta cagcatattg ctgagtgctt 2936521 ctgtggaagt aatctagatg gtccgaaaac tggcgaaagg aaccgaattc atcgtattcg 2936581 tgatgaagat ggggagacgg gaaaaaaaag aggccgtcct ttttccggtg caaatcccat 2936641 tccttacccg ccccaaggtg atccatgagc gaacggtaac gatacttcgg aaaaattgca 2936701 acactcctaa tatccgcatt caccatgttg gaaagcataa aatcaatcag tcggtacctg 2936761 ccggcaaaag ggatcgcccc gagcgaccgc tgtgctgtta aatcctgaag agaatgctta 2936821 tatgtggttt catctataac acctaacatt tgattattga acactgactc tgccccctct 2936881 tcagtaatta aatcaattct ttttctacaa attcctctga aacgagcagc acctcttcaa 2936941 tgtctttttc ggagcgaatc actgcgccat ccggcagcac catcccatta ggaacgatgg 2937001 cattttcaat gactacatgc tccccaatcg tcacatccgg cattatgacg gatgatgtaa 2937061 cagtcgtatg cttaccaaca gtcacacctt gaaaaagaac ggagtgagac acatttccat 2937121 atacaacaca accttcgttc acaagcgaat cttgaacctg cgcatcagat gaaataaatt 2937181 gcggaggctg atttggattg acggagtaaa ttttccattt gcgttcaaac agcttcagct 2937241 ccgagtcctc ttttaacaaa tccatattgg cttcccacaa gctctgcacc gttccgacat 2937301 ccttccaata tcccttgaac ggataagcag aaagcttctt tttctcttcc aaaagcagtg 2937361 gaataatgtc tttgccgaag tcgtggctag aataagggtt ttgatcgtcc atctcaagat 2937421 actgtttcaa aagcggccaa ttgaatatat aaattcccat tgaggcaaga ttgctcttag 2937481 ggaatttggg cttttcatca aaatgtgtga tcgtcccatc tggattggcc ttcatgatgc 2937541 cgaaccggct tgcttcctcc cagcccactt cgatgacaga gatggtcaca tctgctttct 2937601 tttcaatgtg ataatcaagc attttgccgt agtccatttt gtatatgtga tctcctgata 2937661 aaatcagtac atactcagga tcatactgat tcaaataatt gagattttca taaatggagc 2937721 ttgccgtccc tttataccat ttgacttctg atgactcggc ataagggggt aaaaccgtca 2937781 cgccgccatt atatctatcc aggtcccatg cactgccgat cccaatatag gaattcagct 2937841 cgagcggctg atattgcgtt aaaatcccga ctgtgtctat gcctgaatta gaacagttgc 2937901 ttagggtaaa atcaataatc ctgtattttc ccccgaaaga tacagccggt ttggccatat 2937961 tttttgttaa tccgctgaga cggctgccct tcccgccggc aaggagcatg gctacacatt 2938021 gttttttcat ctttttatct ctcctctttt tttaaccgcc cgtaaaatcg agatgccgta 2938081 aggggggatg gtcatcgtga tataacacgg tttatgatga agtgctccct ttttagccga 2938141 taacggcttt ttgttgattt gccctgagcc tccatatgtt tcactgtcac tgttaagcac 2938201 ttcaatgtat tgagtaaaaa aaggaactcc aacatcatat tgatgataga ccacgggtgt 2938261 aaaattacaa atgatgacaa gcgcctcacc gtgcttttgg ccataacgaa taaaagaaaa 2938321 gattgattgt tcgtcattat ggacatcaat ccattcaaac gattgtgcac gatggtcatg 2938381 ctcataaagg attttgcttt tttggtaaaa gcggagaaga tcttgcgtaa aaacgctggc 2938441 tttctgatgc atggggaagg agtccaaaaa ccaatcaagc tgttctgtat ctttccattc 2938501 atcaaattga gcaaactctg atcccataaa gatcaatttc tttccgggat gcactgtcat 2938561 atagcccagc aaaagccgat actgggcaaa tttctgccag tagtcgccag gcattttatt 2938621 gagaagtgat ttttttccgt atacgacttc atcatgagaa aacggcaata caaaatgttc 2938681 actaaacgca tatagtaatg aaaaagagat aagctgatga caatgccgcc tttcttcggg 2938741 cggcgtctcc atgtatttca gtacgtcatt catccatccc atattccatt tataatgaaa 2938801 accaagcccc ccttcctcaa cggcacctgt cacttgaggc cattctgtag aatcttctgc 2938861 aatcatcatc acatggggat atgcctctct catggtttga ttgagttttt ttaaaaaatc 2938921 aacagcatat ggattcgtgt ggcgttcatc ctgatttggc caatacaaga tattagccac 2938981 tgcatcaacc ctaaatccat ctatatgata gaattccgcc cagtacaacg cattcgaaat 2939041 taaaaaacta tgaacttccg gtttccccag gtcaaagttt gccgtgcccc ataaccagtt 2939101 ctcccgatca cgttcttctt tgtattcata aagcggttct ccatcaaaca tataaaggcc 2939161 atgtgcatct ttacaaaaat gtccggggac ccaatccaaa atgactccga tattttgttg 2939221 atgacattca tccacaaact tcatcagatc atgcggcggg ccaaacctgc ttgtcgggct 2939281 gtaatacccc gttccttggt acccccatga acgatcatat ggatgctcat acacgggaag 2939341 cagttcaata tgggtaaacc catgcttctt gatataaggg ataagcgtct gacttaattc 2939401 tttataggaa taatgcctgc catcagaatg cttcttccaa gacccaagat gcagttcata 2939461 aatgaaaaca ggtttttcat acagcgtctt agccttctgt ttcttttgcc atttttgatc 2939521 ttgccagctg tatccttcca aatcgtaagt aagtgacgct gtgtttggtc tgacttctga 2939581 ataaatagcg tatggatctg ccttcagcct gatctcaccg ttattcgtca caatttcgta 2939641 tttatatcgt tccttttctc ctatacctgg aataaataac gtccaaatgc cattatcatt 2939701 cactctgtgc atcacatgct cttctccaga ccagctgtta aaatctccag ccactcgtac 2939761 ttccgacgca tgaggcgccc acacacagaa ttcatatccg cttttgccat tcagctcgcg 2939821 gtaatgcgag ccaaacagct gatagctttt aaacagactg ccttcgtgaa aaagataaac 2939881 atcatgtgct gtcgggctgg cagcggccat gtaatcatcc tttctgacat catagttttc 2939941 atttatagta tttattcgaa gaaataaaaa aaagcccttt cctgaaagcg cttatactta 2940001 tagacaatta acttcatttt ctgaagaaaa acgaaatata tggagatttt tgtagtctgt 2940061 ttttaaaata aagaacaaaa tctaagacat atcatgattt ataaaaacaa aaaaaccttg 2940121 caggatatgc aaggcttctg gatgacccgt acgggattcg aacccgtgtt accgccgtga 2940181 aagggcggtg tcttaaccgc ttgaccaacg ggccgataat tatgatatct gtaatcatat 2940241 ggcggagaag gagggatttg aaccctcgcg ccgcttacac gacctacacc cttagcaggg 2940301 gcgcctcttc agccacttga gtacttctcc atttggctcc acaggcagga ttcgaacctg 2940361 cgaccgatcg gttaacagcc gatagctcta ccactgagct actgtggaac aaaagtcatg 2940421 gtgggcctga atggactcga accatcgacc tcacgcttat caggcgtgcg ctctaaccag 2940481 ctgagctaca ggcccatgac gatatagaaa tggagcgggt gatgggaatc gaacccacga 2940541 catcagcttg gaaggctgag gttttaccac taaactacac ccgcaatttt tatttggggc 2940601 gattgatggg aatcgaaccc acgaatgcca gagccacaat ctggtgcgtt aaccacttcg 2940661 ccacaaccgc caaagcatat tgataaatgg tggctcggga cggaatcgaa ccgccgacac 2940721 acggattttc agtccgttgc tctaccaact gagctaccga gcctaagtat ttaaatggcg 2940781 gtccggacgg gactcgaacc cgcgacctcc tgcgtgacag gcaggcattc taaccaactg 2940841 aactaccgga ccattttaaa atttggttgc gggggcagga tttgaacctg cgaccttcgg 2940901 gttatgagcc cgacgagcta ccgaactgct ccaccccgcg atgattagga atatgtatgg 2940961 cggaggaaga gggattcgaa cccccgcggg ctttgacacc cctgtcggtt ttcaagaccg 2941021 atcccttcag ccagacttgg gtattcctcc gtatagtggt ggaccttgta ggactcgaac 2941081 ctacgaccgg acggttatga gccgtctgct ctaaccaact gagctaaagg tccattggta 2941141 gcggcggagg ggatcgaacc cccgacctca cgggtatgaa ccgtacgctc tagccagctg 2941201 agctacaccg ccaaatattt ttgaaatcaa gtggagccta gcgggatcga accgctgacc 2941261 tcctgcgtgc aaagcaggcg ctctcccagc tgagctaagg ccccaagaat ggtcgggaag 2941321 acaggattcg aacctgcgac cccatggtcc caaaccatgt gctctaccaa gctgagctac 2941381 ttcccgattt catatagatc atggcgcgcc cgagaggagt cgaaccccta accttttgat 2941441 ccgtagtcaa acgctctatc caattgagct acgggcgcaa aacttaatgc cgagggccgg 2941501 acttgaaccg gcacggtagt cacctaccgc aggattttaa gtcctgtgtg tctgccaatt 2941561 ccaccacccc ggcgtggatg gtatagttgg agcggaagac gggattcgaa cccgcgaccc 2941621 ccaccttggc aaggtggtgt tctaccactg aactacttcc gcagaaatgg tgcggatgaa 2941681 gggacttgaa cccccacgtc tgtaaagaca ctagagcctg attctagcgc gtctgccaat 2941741 tccgccacat ccgcaacatg taaatggtga gccatgaagg actcgaacct tcgaccctct 2941801 gattaaaagt cagatgctct accaactgag ctaatggctc ttcttacaat agacttgaat 2941861 attatatcat ataaaagtgg tgccggcaag aggacttgaa cccccaacct actgattaca 2941921 agtcagttgc tctaccaatt gagctacacc ggcatatatg taaaaccgat atgtataatg 2941981 aaaaatggtg gaggatgacg ggctcgaacc gccgaccctc tgcttgtaag gcagatgctc 2942041 tcccagctga gctaatcctc catacttgca ctaacgtgca attgcttggc ggcgtcctac 2942101 tctcacaggg ggaaaccccc gactaccatc ggcgctgaag agcttaactt ccgtgttcgg 2942161 tatgggaacg ggtgtgacct cttcgctatc gccaccaaac aaattgagag tgttctctca 2942221 aaactagata acaggtgtga catcattcaa aaatatggtt aagtcctcga tcgattagta 2942281 tctgtcagct ccatgtgttg ccacacttcc acctcagacc tatcaacctg atcatctttc 2942341 agggatctta cttccttgcg gaatgggaaa tctcatcttg aggggggctt catgcttaga 2942401 tgctttcagc acttatcccg tccgcacata gctacccagc gatgcccttg gcagaacaac 2942461 tggtacacca gcggtgcgtc catcccggtc ctctcgtact aaggacagct cctctcaaat 2942521 ttcctgcgcc cgcgacggat agggaccgaa ctgtctcacg acgttctgaa cccagctcgc 2942581 gtaccgcttt aatgggcgaa cagcccaacc cttgggaccg actacagccc caggatgcga 2942641 tgagccgaca tcgaggtgcc aaacctcccc gtcgatgtgg actcttgggg gagataagcc 2942701 tgttatcccc ggggtagctt ttatccgttg agcgatggcc cttccatgcg gaaccaccgg 2942761 atcactaagc ccgactttcg tccctgctcg acttgtaggt ctcgcagtca agctcccttg 2942821 tgcctttaca ctctgcgaat gatttccaac cattctgagg gaacctttgg gcgcctccgt 2942881 taccttttag gaggcgaccg ccccagtcaa actgcccacc tgacactgtc tccccgcccg 2942941 ataagggcgg cgggttagaa ggtcaataca gccagggtag tatcccaccg atgcctccac 2943001 cgaagctggc gctccggttt ccaaggctcc tacctatcct gtacaagctg taccaacatt 2943061 caatatcagg ctgcagtaaa gctccacggg gtctttccgt cctgtcgcgg gtaacctgca 2943121 tcttcacagg tactataatt tcaccgagtc tctcgttgag acagtgccca gatcgttgcg 2943181 cctttcgtgc gggtcggaac ttacccgaca aggaatttcg ctaccttagg accgttatag 2943241 ttacggccgc cgtttactgg ggcttcaatt cgcaccttcg cttacgctaa gcgctcctct 2943301 taaccttcca gcaccgggca ggcgtcagcc cctatacttc gccttacggc ttcgcagaga 2943361 cctgtgtttt tgctaaacag tcgcctgggc ctattcactg cggctctctc gggcttgcac 2943421 cctaacagag caccccttct cccgaagtta cggggtcatt ttgccgagtt ccttaacgag 2943481 agttctctcg atcaccttag gattctctcc tcgcctacct gtgtcggttt gcggtacggg 2943541 cacctctcac ctcgctagag gcttttcttg gcagtgtgga atcaggaact tcgctactat 2943601 atttcgctcg ccatcacagc tcagccttat gggaaacgga tttgcctatt tcccagccta 2943661 actgcttgga cgcggatatc caataccgcg cttaccctat cctcctgcgt ccccccattg 2943721 ctcaaatggt gaggaggtgg tacaggaata tcaacctgtt gtccatcgcc tacgcctttc 2943781 ggcctcggct taggtcccga ctaaccctga gcggacgagc cttcctcagg aaaccttagg 2943841 cattcggtgg aggggattct cacccctctt tcgctactca taccggcatt ctcacttcta 2943901 agcgctccac cagtccttcc ggtctggctt cacagccctt agaacgctct cctaccactg 2943961 ttcgaagaac agtccgcagc ttcggtgata cgtttagccc cggtacattt tcggcgcaga 2944021 gtcactcgac cagtgagcta ttacgcactc tttaaatggt ggctgcttct aagccaacat 2944081 cctggttgtc taagcaactc cacatccttt tccacttaac gtatactttg ggaccttagc 2944141 tggcggtctg ggctgtttcc ctttcgacta cggatcttat cactcgcagt ctgactccca 2944201 aggataagtc attggcattc ggagtttgac tgaattcggt aacccggtag gggcccctag 2944261 tccaatcagt gctctacctc caagactctt accttgaggc tagccctaaa gctatttcgg 2944321 agagaaccag ctatctccag gttcgattgg catttcaccc ctacccacac ctcatccccg 2944381 cacttttcaa cgtgcgtggg ttcgggcctc cattcagtgt tacctgaact tcaccctgga 2944441 catgggtaga tcacctggtt tcgggtctac gaccacgtac tcatgcgccc tattcagact 2944501 cgctttcgct gcggctccgc atcttctgct taaccttgca cgggatcgta actcgccggt 2944561 tcattctaca aaaggcacgc catcacccgt taacgggctc tgactacttg taggcacacg 2944621 gtttcaggat ctctttcact ccccttccgg ggtgcttttc acctttccct cacggtactg 2944681 gttcactatc ggtcactagg gagtatttag ccttgggaga tggtcctccc ggattccgac 2944741 ggaatttcac gtgttccgcc gtactcagga tccactcagg agagaacgaa gttttgacta 2944801 cagggctgtt acctcctatg gcgggccttt ccagacctct tcatctacct cgttcttttg 2944861 taactccgta cagagtgtcc tacaacccca agaggcaagc ctcttggttt gggctgatcc 2944921 cgtttcgctc gccgctactc agggaatcgc atttgctttc tcttcctccg ggtacttaga 2944981 tgtttcagtt ccccgggtct gccttctcat atcctatgaa ttcagatatg gataccactc 2945041 cattacgagt ggtgggtttc cccattcgga aatctccgga tcaaagcttg cttacagctc 2945101 cccgaagcat atcggtgttc gtcccgtcct tcatcggctc ctagtgccaa ggcatccacc 2945161 gtgcgccctt tctaacttaa ccgttaaaaa gaatcactat gtgatatctt gtgttactaa 2945221 ttgaatgtga tgtctactgt tatctagttt tcaaagaaca cgtttcgaag gaatgatcct 2945281 tcaaaactaa acaagacagg gaacgttctg tttataagac cttgggtctt atattccgta 2945341 taatatcctt agaaaggagg tgatccagcc gcaccttccg atacggctac cttgttacga 2945401 cttcacccca atcatctgtc ccaccttcgg cggctggctc ctaaaaggtt acctcaccga 2945461 cttcgggtgt tacaaactct cgtggtgtga cgggcggtgt gtacaaggcc cgggaacgta 2945521 ttcaccgcgg catgctgatc cgcgattact agcgattcca gcttcacgca gtcgagttgc 2945581 agactgcgat ccgaactgag aacagatttg tgggattggc ttaacctcgc ggtttcgctg 2945641 ccctttgttc tgtccattgt agcacgtgtg tagcccaggt cataaggggc atgatgattt 2945701 gacgtcatcc ccaccttcct ccggtttgtc accggcagtc accttagagt gcccaactga 2945761 atgctggcaa ctaagatcaa gggttgcgct cgttgcggga cttaacccaa catctcacga 2945821 cacgagctga cgacaaccat gcaccacctg tcactctgcc cccgaagggg acgtcctatc 2945881 tctaggattg tcagaggatg tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa 2945941 ccacatgctc caccgcttgt gcgggccccc gtcaattcct ttgagtttca gtcttgcgac 2946001 cgtactcccc aggcggagtg cttaatgcgt tagctgcagc actaaggggc ggaaaccccc 2946061 taacacttag cactcatcgt ttacggcgtg gactaccagg gtatctaatc ctgttcgctc 2946121 cccacgcttt cgctcctcag cgtcagttac agaccagaga gtcgccttcg ccactggtgt 2946181 tcctccacat ctctacgcat ttcaccgcta cacgtggaat tccactctcc tcttctgcac 2946241 tcaagttccc cagtttccaa tgaccctccc cggttgagcc gggggctttc acatcagact 2946301 taagaaaccg cctgcgagcc ctttacgccc aataattccg gaaaacgctt gccacctacg 2946361 tattaccgcg gctgctggca cgtagttagc cgtggctttc tggttaggta ccgtcaaggt 2946421 accgccctgt tcgaacggta cttgttcttc cctaacaaca gagctttacg atccgaaaac 2946481 cttcatcact cacgcggcgt tgctccgtca gactttcgtc cattgcggaa gattccctac 2946541 tgctgcctcc cgtaggagtc tgggccgtgt ctcagtccca gtgtggccga tcaccctctc 2946601 aggtcggcta cgcatcgttg ccttggtgag ccgttacctc accaactagc taatgcgccg 2946661 cgggtccatc tgtaagtggt agccgaagcc accttttatg tttgaatcat gcggttcaaa 2946721 caaccatccg gtattagccc cggtttcccg gagttatccc agtcttacag gcaggttacc 2946781 cacgtgttac tcacccgtcc gccgctaaca tcagggagca agctcccacc tgtccgctcg 2946841 acttgcatgt attaggcacg ccgccagcgt tcgtcctgag ccaggatcaa actctccgat 2946901 aaatggatca caggttaagt tcaccgcatc ctgcggcgac acctgtgtga cctgcgtcgt 2946961 gcaggcccta gtttgactga ctacgcacat cgcagtgcga tttttaaaaa ctgaattaac 2947021 aggtacgttt tgtcttgttt agttttcaaa gatcatttcg ttacttctca atgaagcagc 2947081 tttactaata taacattcag cttctttttt gtcaacaact tttttcaagt tgttttgaag 2947141 catctagttt gtgtccgctg tgcatcagcg acgtttaata atataacacc tgtatttatt 2947201 tattgcaata gttttttaaa aaaaatctat aaaacaaata aactataatc ctcgccatga 2947261 tttctaaagc gtgtgtatca tataagtttc ttaaaagaac atatacatca gtcatgtgat 2947321 cttgttgttt ttttcgtttt cttgtatagt agaaacgaac taaatactga tgaccacaag 2947381 gggagcatta aagctgagag tgagcggttt cgttctgacc ctttgaacct gttagttaac 2947441 gctggcgtag ggatgtggca aagtcaaatg aattgcagat cgtaaagcag tgcgtggaac 2947501 ttttctcatc cttccgcgtg ctgctttttt gttgtccttt tggttgtctg tcaatggaag 2947561 gagatagata tgaatcaatc taagcaactg gttcgcctta ttgaaattgc cattatgaca 2947621 gcggcagccg ttattttaga cattgtctca ggaatgtttc ttagcatgcc tcaaggaggc 2947681 tcggtctcca tcatgatgat tccgatcttt ttaatttcgt ttcgctgggg tgtcaaagca 2947741 ggtcttacta caggtttgtt gacaggtcta gtacaaatag caatcggaaa cttgtttgct 2947801 caacatcctg tacagctatt gttagattac attgtcgctt tcgcagcaat cggcataagc 2947861 ggctgtttcg cttcttctgt ccgtaaagcc gctgtatcaa aaacaaaagg gaaattgatt 2947921 gtttcagtgg tcagcgcagt ttttatcggc agtttgctgc gctatgccgc gcatgtcatt 2947981 tcaggagctg tgtttttcgg cagctttgct ccaaaaggaa caccggtatg gatttattct 2948041 ttaacttata atgcgactta catggttcct tcattcatta tttgtgcaat tgtcctatgt 2948101 ttattattta tgacagcacc ccgtctgctt aaaagtgaca aagcgtaaaa gtaacaatcc 2948161 cccagcgaat tccgctgggg gatttttcgt tatctgttaa gaagtgtttt taaagctgaa 2948221 agatccggcc agccaagacc tacttctttc agccttactc cggcaatttc aaagttgtcc 2948281 tccgctactc tttcaggtga ataggcctga taaaatataa tcgagggatt ctgctcaata 2948341 acccaaacaa acatacttga aaaaccatgt tgaagcaaaa actccgctcc ttttgctaag 2948401 agcgccctgc ctgcaccttg ccgctggcgc tcttccagaa gataaatagc gtataactcg 2948461 ccgtcatagc cttcttgttc agagcgaata ggtccaaatg aagcaaagcc gaatactgaa 2948521 cccttttcgt cctgagcaac aaatactccc tttaacgagc gacttttcca tttgtcttca 2948581 aattccttat agttcaggct gtttaaataa tcaatcggga taatttcgtg gtatgttgtc 2948641 ctccagctgt ctacatgcac ttttgcaatg tcctttatat cctctaactt cgcttcacgt 2948701 acagttacca tacggttctg ccctttcctt actctgattt ttggatcgtt ttggcttctt 2948761 tgatttcatt tgttaattca ttaatgcttt gttttacgtt tccttttcct gaaaagttct 2948821 caagcatttc ttttacatca attcctgagg atgcttttaa actttcttgc agacttgaca 2948881 ttaagttcgt cgcatagctg gttactttgt ttgctccgct tgattcaccg cttcctcctg 2948941 tatcgacaac ggtgatttta tcaatatttg aaagaggtgc cgctgcttgt ttcgcgtatt 2949001 ccggaagcat tttgacaatc atatcgaaaa tcgccgcctg cccgtactgt tcaaaggcgg 2949061 ccgcaatttt ctcttttgct tccgcttctg caagaccttt caggcggata acctctgctt 2949121 ctgtctctcc tttcgctttt tccgcttctg cttttgctag cccgtcaatt cttacttttt 2949181 ccgcctcagc ctttgccatt gcttcaatac tgtacttctt ggcatcggct tccgcgagct 2949241 gtttggcttt ctcagctgct gcggactgct caacagaata acggtctgca tcggcttttt 2949301 tctttacctc tgagtcgtat tgacgttcac ggcgaagaat ttctttttct tctagttcta 2949361 tttgtttttg gcgttcgata attttaacct gcatttcctg ctctgtgact tgctggcgcg 2949421 ctcgggcagt ctctaaatca tatgcttggt cggcattcgc ttttgccgta tcttgttctc 2949481 tgcggaattc agccattttg agctgattga ttttttcagc ttcagcgatt tccgtcgccc 2949541 gttcaagttc tgattttttt gcgtctttat cggcttctgc ccgcttaatt cgggtttctt 2949601 tatcagcctc tgctgttgcg atatcagcat cgcgttttac ttgggcaatt ctcggtttcc 2949661 ctaatgattc aagataaccg tttttatcac gaacatcttt aatggtaaac gagacgatta 2949721 caagtcccat tttcgcgaga tcctgtgaag cgacacgctg cacctcttga gagaattttt 2949781 ctctgttttt atagatttct tctactgtca ttgagccgag aatggaacga aggtggcctt 2949841 ctaaaacctc ccgcgcttcc tgctcacggt cgtcttttga tttccctaaa aattgttcgg 2949901 ccgctgtagc gatttctcct atagaaccgc cgattttaat aatcgcagtt ccatcggcca 2949961 ttactggcac tccttgttct gtatagactt caggtgtcga aacatcgagt ttgcttgata 2950021 ataggcttag cggctctgcc tgctggaaga cgggaaggac aaaggttcct ccgccgcgga 2950081 cgattttaat acggttgccg ccttcatcga catgaacatt tttattaccc agatagctcc 2950141 ctgttacaat taacgcttca tcaggccctg ctgtacgata cttcgtaata aacacagcta 2950201 ttagtgcaat taataaaaag aatacaactc cgatgatcat tataatcggc attgtcatat 2950261 caaattcctc cttttatgtt aaatgggttc atgcggagta accgaaagaa ctccgttgtt 2950321 aatatctacg actaacaccg ttgtcccgta actgatctgc tgattatcaa aactgaccgc 2950381 tgactttgaa atggtcccgc ctatcccttc tatgaccact tcaccaaacc cgtcaaccgg 2950441 cacagctgta atcactttac cgagtcttcc tctgagatca tcttctctat atgccaatga 2950501 ttcttctgca gatgataatg gcaccagtac aaagatgtga agcaatacca ccagcatgat 2950561 cgaaaggatg caagataaaa gcgcaatcag caagcttgac agaggcaata caagttcacc 2950621 tatatatccg cccgctgaaa aacatgtaaa aaatgagagc actaatgtcg gattaagaaa 2950681 cggaatgcct tctgacagcc ctgaaaatac atctccgaaa aacaggaata acagcgtaag 2950741 gctgcccgca ataataagcg tataaagata cattgtttgt ataggtactc caaataactc 2950801 caacttcctc atcctttctt catcaatgca ttgatgaacg gctgccgtta ccatttatac 2950861 gagacacctc gggaaaagtt tcaaaatttt aagacaaata acccatttga agtgctttat 2950921 aaatgataat tgcttatata tatggtaatg tcattttagg aggagatatg atgagtatct 2950981 ttaatgaagc cagattagaa acgtggaacg aattgaaagg actttctgac gaaaagctga 2951041 atcaaaagcc ttctgctgaa gaatggagca tacgggaagt tcttgaccat ttgaaaaaaa 2951101 tcgatatgac cgcacaaaaa atgttgaagg aacgtgtaaa ggacgctccg attaaagaaa 2951161 ttgaagaaaa accgcttgaa gtagcacagg acagaaataa taaacggaaa gccccgagtc 2951221 atcttgagcc tgcgcatgat tttatttcag gcagccaaat gaaacgtgag cttgatgtgg 2951281 taagagagca gctgactgct gcgattgcct ctctgaaaga agaagatttt gaaagagtgc 2951341 ttccgcatcc tgtgtttcaa gagctgactg tcagacagtg gatcgatttt atcggccatc 2951401 atgaaaaacg gcacctcagc caaatgaaag aaattaaaga aaagatagaa agggcctgat 2951461 ttaatcagac cctttctgct tttcgtttga cttttcgctg ataggaatga acttctattt 2951521 catcacctgt gtaaacagca ccaggtctct ccacaataca gacaatccct ctaatgccca 2951581 gtgcgtggcg gacgaaagcc gacgccagct tcggttggtc cggataataa gactgaatga 2951641 cttctcccgg ctggatacac ggatcatttt cgccctcaca cagcagagcc gctccgctcg 2951701 gaaaaataat ccggcttcct tcttttaatg aagtaagatc tggcataccg ctgactgcca 2951761 cattcgcccc gagccattcc ggcaaaattc tcggcactcc catttttaaa gcgatttcgt 2951821 tgcattcctc tattgaaaca attgaaattt gtctgcggtt gaaaatttca gtccctcttg 2951881 aaaacattgg ttctctggct cccgcttttt tggtcaggcc aaaatgcaag tcgccgggga 2951941 tgccgccata atcaaaatca agcttgtcca tttgctttgt tacgaagctt tttgtatctg 2952001 cgatatataa gccttccgct tttgcagtca tacgcttcca catcagctgg caccttcctt 2952061 cttatctaaa atttccacct atgcttcatt atcccaaaaa atcccgctct gtaaaggagc 2952121 gggattttga ttataccgtt ttaggcgtaa ggttaaagca gcgtttgtag atccagttgt 2952181 atgctttttc atttaaatct ctagggtttc cgaaggtttg cggatctttc attgcttctt 2952241 tagacaagcg ttcgatcata tcaggtgata ctccctgctc ttctaaagtc ggcacttcta 2952301 aatcttcgac cagatcatac atccaattga cagatgcttt cgcagcttct tctgttgtca 2952361 tcttgcttgt atcaataccg aacgctttcg caatacgcgc aaacttctca ggatagccct 2952421 tccagttgta ttccatgaca gggcccatca tcgccgctac acattggccg tgagcgactg 2952481 ggataatacc gccaagcgtt tggctcatcg catgagcagc gcccgctgat tcacttccgt 2952541 aagaaagacc ggcaagcatc gcagcctgcg ccattccgta ccttgcttcc agatcctctc 2952601 catcagcaaa tgccctcttg atgtaatgag cggcatactc aatcgccatt aaggcaaccg 2952661 catccgtgat tggctgtgca aatttcattg tatagcactc aatggcatgg gcgagcgcat 2952721 caattcccgt catagctgtt acatgcggag gcattgaaac atgaagctca ggatcaatga 2952781 ttgtcaagtg cgctgcaatc agcggaccgc ccgtgttgaa tttgaattct ctttcttcat 2952841 ctgtgataac cgcccattgg gttacttctg atccggttcc agctgtagtg ggaattgtcg 2952901 tcagcggagg aatgcggttt tccagcggtt ttttcccatc tgccgcttca taatcaagca 2952961 cgcttccttc gtgagtcgct tctactccga ttgcttttgc tgtatccatg gagcttccgc 2953021 ctccgactgc caccaaacca ttacagttct cttttttgta aagctcagat ccttcattca 2953081 ccagacggac aggcgggttt ggctcaactt tattaaagag taccacttca atgcctgctt 2953141 ctttaagtga ttcgattacg ggatcagcaa caccggcttt ataaatccca gggtctgtga 2953201 caaggagcgc ttttgaaacg cccagtgcag ctacttcctc acccgtatgc ttgatggctc 2953261 cgattccatg cttaatcaca gtcggaattt caaatgtgtg gaatttctgc atgctttcta 2953321 ccttcatatt taatgtcatc atcaatctcc ccctcttatg aattaaacca gttaaccgct 2953381 gccggttttg tattgcggta tacatgtttg acttctgtgt attcttcaag gcctattttt 2953441 ccaagctcgc gtccgaaccc ggattgctta tatccgcccc atggcgcttg tgcaaagtac 2953501 ggatgaaaat cgttgatcca aacggttccc attctcaagc gggctgctac ccgttcgcac 2953561 ttttcaatgt cttttgacca taccgctcca gccaagccat agatggtatc attcgcaagc 2953621 tcgattacct cttcttcaga gctgaaggtt tcgactgtca atacaggacc gaaaacctct 2953681 tcctgaacga ttctcatgtc agaattacag tttgagaaaa tagtaggttc atagaaaaag 2953741 ccgttttgaa gctcaggatc ttccgggcgt ttgcctcctg tctccagctt cgcgccttcc 2953801 tctattccga tctctacata tttttctacc tttgccctgt gctccgccga aataagcgga 2953861 ccgctttctg tctcagcatg aaaaccgttt ccgagtttta tgcgttttgc ccgtttgacc 2953921 agctccgcca aaaattgatc atgaatggca tcctcaacaa gcaagcggga acctgcagag 2953981 catacttggc cggcgtggaa aaatacagcg tttaaggcct gatcaaccgc aacttctaaa 2954041 tccgcgtcct tgaaaacaat atttgggttt ttcccgccaa gttcaagggc gatttttttg 2954101 acgtttccgc ttgccgcccg catgattttt ttgcctgttt caattccgcc cgtaaatgaa 2954161 atcaaatcga cgtctttgtt tacggcaagc tcgtcgccca ctgtggctcc cggtccaaga 2954221 acaagatttg cgacaccttt tggaacaccg gcttcttcca tcagcttaaa gactttgatt 2954281 gtcgtcagcg gcgtaatctc actcggcttc atgacgattg tgtttcctgc ggccagtgca 2954341 ggggcgattt tccagctcgc ttgaaggagc ggataattcc atggagtgat ctggccgcaa 2954401 accccgattg gctccctaat aattttgctt tctgaatcag gaatcggaga tgaaatgatc 2954461 tctccgccat ctttgtctgc caagccggcg taatattgaa aaacattggc gatatcgtcc 2954521 atatcggcct tgctttcttc gagtgttttt cctgtatcaa gagattcaag ctcagccagc 2954581 tcctcaagat cgcgtctgat taattccgca attttcagaa caatttttcc gcgttcaagc 2954641 ccggatagcg atgaccattc tcctttgtca aatgctctac gtgcggctgc gattgctttg 2954701 atggcgtcct ctcgccctcc ctcgcttaca gttgcaattt cttcttgatt aaatgggttg 2954761 ataatactgc ggatctgttc tttttcggca ctgatccatt ctccgtcaat gaataatgtt 2954821 tgactcatat aagcctcctt gacgtaaata aagtttgtta aataaaaatt taatgttttt 2954881 aacaacctta atctaacata tggtttttaa actgtcaaag tcccattttg atttttcttt 2954941 ttgacttttc ctcatgtttc gttaagataa agaacataaa gaaataactt aacgaattta 2955001 attttctaaa ggaaaagagg gtcagtatgg atgaaaatcc agaatttgca gctatagaac 2955061 aggctcggga tcttgttatt gactccattg ctgaaacgat ggatctttac ggaattaccc 2955121 gcagtgtcgg gattttatat gggacgatgt atatgaggga tgagatgacg cttgacgaaa 2955181 tgcgtgagga gttgcaaatg agcaaaccaa gcatgagcac tggcgtcaaa aagcttcaag 2955241 acttaaatgt agtgaaaaaa acatttcacc ggggcatccg caagcataca tttgtggctg 2955301 agaaggattt ctttaaattt ttcacaaatt tctttccacc taaatgggag cgggaggttc 2955361 aagtgaatgt aacagcgatc gaggaagctc aagctgattt acaaaaggtt ttatgcaagg 2955421 aagatctcga tgaggatatc aaaaatgaag cactgcagtt atatgatcag ctggaaagct 2955481 ctaaagctta ctatgactgg ctgaaacggc ttgctgaatc ggtgcagacc ggagaaattt 2955541 ttaaatttat accggtcgaa acaaagtaaa gcagaaaacg cctgggaaac taggcgtttt 2955601 tttgatgtaa ctactacaaa tttgaaaaat acgggaaaaa caccccattt acttccaaaa 2955661 tatttgatgg taattttatg taggtaaaat ttgtatttgg cctttcagag gaggtgaaaa 2955721 gcgggcaggc ctgtttaatt tatcattttt tagggggaat tttgttatga aacgcaaatt 2955781 attatcttct ttggcaatta gtgcattaag tctcgggtta ctcgtttctg cacctacagc 2955841 ttctttcgcg gctgaatcta catcaactaa agctcatact gaatccacta tgagaacaca 2955901 gtctacagct tcattgttcg caacaatcac tggcgccagc aaaacggaat ggtctttctc 2955961 agatatcgaa ttgacttacc gtccaaacac gcttctcagc cttggcgtta tggagtttac 2956021 attgccaagc ggatttactg caaacacgaa agacacattg aacggaaatg ccttgcgtac 2956081 aacacagatc ctcaataacg ggaaaacagt aagagttcct ttggcacttg atttgttagg 2956141 agctggcgaa ttcaaattaa aactgaataa caaaacactt cctgccgctg gtacatatac 2956201 tttccgtgcg gagaataaat cattaagcat cggaaataaa ttttacgcag aagccagcat 2956261 tgacgtggct aagcgcagca ctcctccgac tcagccttgc ggttgcaact aatgtaaaag 2956321 accggttaac gccggtcttt tttgcgtttt accctcccct ttttctctaa tccccgttat 2956381 cttttttctg gtttaaaatt taaattgaca aacactagaa acaggagtaa attcttgagt 2956441 gttcaatttc atacagtctc ttttaccgct taatcaaaca cgaacggggg aaccaacgat 2956501 tggctgtttt attaacagcc ttggggtgaa tcttactaag taagaggggg tactctgaat 2956561 ccctaatccg acagctaacc tcgtaggcgt atacagagag gaggtctatt atcggccatt 2956621 ctttgcaatg gtcttttttg tttcaaaaac gttaattcac taagggagat atgaacattg 2956681 ggaagaatta aaaataagca atttgccgtg atcgggctgg gccggtttgg cggcagcatt 2956741 tgtaaagaac ttcatagaat ggggcatgag gtccttgcgg ttgatatcaa cgaagaaaag 2956801 gtcaatgcat atgcttctta cgccactcat gcggtaattg ccaacgccac cgaagaaaac 2956861 gaattgcttt cattaggaat acgcaatttt gaatatgtga ttgttgccat cggagcaaat 2956921 attcaagcga gtacgctgac caccctatta ttaaaggagc ttgatattcc aaatatttgg 2956981 gtgaaggctc aaaactatta tcatcacaag gtgcttgaaa aaataggcgc tgaccgcatt 2957041 attcatcctg aaaaagatat gggggttaaa atcgcacaaa gcctttcaga cgaaaatgtt 2957101 ttgaattaca ttgatctatc tgatgaatac agtattgtcg agctgctggc tacgcgcaag 2957161 cttgattcaa aatcgattat tgacctgaat gtaagagcaa agtacggctg cacgatcctg 2957221 gccattaaac atcatggaga tatctgtctt tcccccgcgc ctgaagacat cattcgcgag 2957281 caagattgcc tggtgatcat gggccacaaa aaggatatta aacgttttga aaacgaaggg 2957341 atgtagacaa aggtgacact tcaaaaggat aaagtgatca aatgggttcg gtttacaccg 2957401 cctcaagtgc ttgccattgg ttttttcctt accattatca tcggggctgt cctattaatg 2957461 cttccgattt ccactacgaa gccattgtca tggatagatg ccctttttac tgcggcttcc 2957521 gctacaactg ttacagggct tgctgttgtc gataccggca ctcaatttac ggtattcggg 2957581 caaacagtaa ttatggggct gattcagatt ggcgggcttg gatttatgac atttgcggtc 2957641 ttgatcgtca tgatattagg aaaaaaaatc ggcttaaaag aacgaatgct cgtccaggaa 2957701 gccttaaacc agccgacaat cggcggtgtc attggccttg tcaaagtcct gtttctgttt 2957761 tcgatcagta ttgaattgat agcagcactc attttatcca tccggcttgt acctcaatac 2957821 ggctggtcat ccggcttgtt tgcaagtttg tttcacgcaa tatctgcttt taacaatgcc 2957881 gggttttcgt tgtggcctga taatttgatg agctacgttg gcgatcctac agtgaacctc 2957941 gtgattactt tcttatttat tacaggaggg atcggattta cggttctgtt tgatgtgatg 2958001 aaaaatcggc gttttaaaac tttttcttta catacaaagc tcatgcttac aggaacgctg 2958061 atgttgaatg cgatcgctat gcttacggtc tttattttag aatacagcaa ccccggcacg 2958121 ctcggccacc tgcatatagt ggataaactg tgggcctcct attttcaggc agtgacgccg 2958181 agaaccgcag ggttcaattc tctagatttt ggaagcatga gagaaggaac aattgtattt 2958241 actttattat tgatgtttat cggagcagga agcgcatcaa cggcgagcgg cattaagctg 2958301 actacgttca tcgtgatttt aacatctgtt attgcttact tgagaggtaa aaaagaaacg 2958361 gttattttcc gccgttccat caaatatccg attatcatta aagctttagc tgtgagcgtc 2958421 accagtttgt tcatcgtgtt tttagggatt ttcgccctga cgatcacaga acaagcgcca 2958481 tttcttcaaa ttgtgtttga aaccttttcc gcattcggaa ctgtcggcct tacgatgggg 2958541 cttactcctg aactgacaac agctggcaag tgtatcatca ttgtcatcat gtttatcgga 2958601 agaattggtc ctttaacgtt cgtgttttca ttcgcaaaaa cagagcaatc aaatatccgt 2958661 tatcctgatg gcgaagtgtt tacagggtga tatcaaaaaa atccggcgtg cagtcgccgg 2958721 attttttatg attcgatatg agattgattt tgtctttttt cctgttccgc gatgatttcg 2958781 ttatcctccg cgttatcacg ggtcactttt tgcgtaagaa tcgcaccaac tgctacaagt 2958841 atcataacag cgatgtaata acctttttca ttgagttcca gattatcagc attatagagt 2958901 ccgatactaa acaaaaatac tcccgcaaaa aaagtaaaat aagctagtac tgtaaaggca 2958961 accgtgtttc tgcgtctata tttctgcacc tttgttccct cccgaaagca tagttaaaaa 2959021 gtgataactt ccgtggaata ttatacctca aattccccgg aatggaacaa agaattaaaa 2959081 ataccagtaa aaagggctta ggttgcctcc tttatttcaa cagctgaatc atcaatccag 2959141 ccgataagtt tatcattgat ttggaattgg taccatacag actggccttt ctgtttttta 2959201 gacacaacct ttatgtcttt gccgacgtaa gattgggcag aggtaagcct tatggaccga 2959261 tcatcagtag aaggcttgga ccatacgtct tgaacggcac tgtctttaat agaggcgttt 2959321 aaatccacag atttgaggga tggatttacc tcatcgtact catctaaatc gtatttttcc 2959381 acaatagcgc tgattttgtc agcgtagtca gggtctgtag catatcctga tgtttgcagg 2959441 gcggttgccg cttccttata attccctgcc tcaagcaccg gtttatactt ctttttattc 2959501 cacgatgtgc cacggacgaa caattgggcg tgatcatcca tagattcaaa aaacgtgctg 2959561 tattttcgaa acttcgcgcg aatggttttt cttttccctt tttcaacttc gtccgtttcc 2959621 atcgtgacat gatggccttt ataattccct tttacgccaa aaaggttgtt ggccttagca 2959681 gccagttcac tgttccccca gtccgattcg agaatggcct gagcaattgt gatgctgggg 2959741 agaacatggt atttttcata caaaatttgg gcatgtccgg acagactgtc tataaatact 2959801 tgctgttcat cgatttcttc agtttctttg gatatttcaa tcggttttga taaagttgtc 2959861 gctaaaacaa acagagctag cggaatcgat acaaggaaaa atagtgaaat caagagttta 2959921 cgttttttaa gttttttacg ggccatgaaa accttccttc gaattaaaag attacgaatg 2959981 taaaagaatc taccttttag aattttactt gcacttctaa tatttttcaa ttctttaggg 2960041 ataaagttgg gaaaagattg caaaataaaa accttttcgc tcaatgaaaa ggtttttacc 2960101 atgtttctat ttttgtaaat ttctgagtgc attccgatat tccgtatcat ttattacttt 2960161 atatgatttg acagttgcct tcgacaaacc ttgtgctgag acggccggtt tttccggagc 2960221 tgttttcgct ttatcatgtg gtttatgtgc cagcttgtgc cccattccag tggcattcat 2960281 acaaaatgac aggcagacga gcagcacgct aaggataaaa gaaatgaaga agagatcatg 2960341 ataagcagtc atcatagaat cctgtaccga accgctttgt ctggcagcat cttttttcgt 2960401 gaaaaagccg atgagaatgg gaactcccat atagacaaac aatcttaaaa actgaacagc 2960461 tgtcattctc ttgaccaaat caggcagcgg gcctcccatg gcagctccca tcagccctgc 2960521 ggcgactgtc aggcctgttc ccgctgcaag catgataaac agtgccgcga acatataaag 2960581 agatgatcga tcctgtatat gcagccattg aaaattcaca aaaacgagaa tgagtccgcc 2960641 gataataccg agcatccctg gtccgacttt atcgtataac agagcgctca aaatggccgc 2960701 gatcgccact ccgattaaaa gagtcaagct taaaagaatg agatgctcct gagaaatatc 2960761 atacatttga cggagcaagc cttgaaaagc agaaaggctg acagctaccg ttatcgtccc 2960821 tgcagctatg atcaataagc cgagcaccgg ttttggcagc agcatcagtt taatagatat 2960881 gaaggggttt ttcactttat attccacaat caatagacca atgagcaaac ataacgtcac 2960941 cccgaaacca atccatacat aacccgatga cagcccccat ttttgcagaa aaatgaatga 2961001 aaccgctgag gctgcggcaa ggaagacaga taaaagaatt cccgcacgat caagcggctg 2961061 ttcttgatcc gccgctccgt gatgctcatc atgaagaaag aaatagctca ccgcgacacc 2961121 gatcagggac aaggtgccaa agatgaaaaa cagccatctc caatgcccgc agcttgttgc 2961181 aatggttccc aggattgtac cgatgataac agaaccatag aatcccccga tcagcacaag 2961241 cagtgcatag ttcctgcgtt caatcgggaa tgacagtaca agcattggaa tcataatcat 2961301 cagcatgacg cctgttgccg ccccttgtaa aaagcgccct gccgccatca atgcaatatc 2961361 gcctgaacat gcgatgagca gtgagcctag tataaagaca ggtaatgaag ccagatagac 2961421 gggacgagca ccgaattttt tcctcagcag cggtcctgcc ggaactaaca aggcaaaggc 2961481 catattgccg atcaatatcg gatttactga tgtaaagaca cttgttccaa ccgttttctg 2961541 aacaaggcct tgaactgacg acaatgccgt gttagacatc aatcccggcc cgaccgctaa 2961601 gacggcgagc aaagaaatca cccaatagtg ttttgtcttc atgttgtcat cccttcctat 2961661 atgaatacat gcgaaacaca tcattttttg aaaacaaaag aagctaatag attttgcata 2961721 ccattagctt tcattctaat attctccctt tcaggggaaa tgatattatt ttattataat 2961781 tatgtgaatg aatgagcata taatcaaata ttatttcaaa tcgattgtgt tttgtcaatg 2961841 gagtaaattt caagcacaac atagaaagct tgaaagcttt tccccgatat tgtgtctaga 2961901 actgcactta tgaatccctg ctcgttccct caagcgaatt aaagcaggcc gttttaatcc 2961961 tttcaatcca ctattccaac taataaactc aaataagttg gtgataagac aacattttac 2962021 ccccacattt ttttgtgttc actgggcgtt tgccgcctct aaattgtata tgggtaaata 2962081 ccatgaatta acctatgaaa taccaatgta agggaggcaa aaacgaatgg aactgtatga 2962141 gtgtatccaa gacatttttg gcggcttgaa aaatccatcg gttaaagatt tagcaacgtc 2962201 tttaaaacaa attccaaacg cagcaaaatt gagtcaaccg tatattaagg aaccagacca 2962261 gtacgcttac ggccgaaatg ccatctatcg aaataatgaa ttggaaatta tcgtgattaa 2962321 cattccgcca aacaaggaga caacagtaca cgatcatggt caatccattg gttgtgcaat 2962381 ggtgttagaa ggaaagcttc ttaattctat ttatcgttca accggcgaac acgcagaact 2962441 ctccaattca tactttgtcc acgaaggaga atgccttatt tcaaccaaag gtttaattca 2962501 caaaatgtcc aatccaacat ctgaacgaat ggtgtctctt catgtctact cccctccttt 2962561 ggaagacatg acggtctttg aggaacaaaa ggaggtattg gaaaattcat gattgacaga 2962621 taaactgctc actttgactt cactcaactg gaggattcag agaatgaaac cttttcctca 2962681 aaacaaaaaa acccttatcg aataagggtt taaaggtatg gagccaaggg ggctcgaacc 2962741 cctgacctct acgctgccag cgtagcgctc tcccagctga gctatggccc cgtatgtaac 2962801 gtcatgttta ttatagatga ttttattttg aaaaacaagc tgtttcctct tgaattgaca 2962861 gaaaaaataa ggctcggaaa agagccttat ttttcgactt acatcatgat caaaagtaaa 2962921 atcacaccga gaataattcg atagattgca aatgggacaa gtttgatttt gttaatcagc 2962981 cttaagaaga aacggacgac aaacagtgcg accacaaagg cacagataaa gccgacgatg 2963041 aaaaacggca tcagatccga acttaagctg tcccaatgct tcacgaggct tagaaagctg 2963101 gctcccatca tgatcggcat cgccataata aacgtaaagt cggctgcagc tcggtggttt 2963161 aatccgagaa taacaccgcc ggaaatggtt gaacccgaac gcgagaaacc aggccaaagg 2963221 gaaagacatt ggaataagcc gacggctatc gcctgtttat aggaaatgcg gtcgagtgtg 2963281 tctgtcgctg ttttccgttt attgacccag tcagcaaaaa gcatgaggat tgccccggca 2963341 attaaaccga tggccacagt tttaacggaa aataaatatt catcaatgta atcttcaaac 2963401 aaaaagccga gaacagctgc aggcacgagt ccgacggcaa tttgggcaat gcttaattta 2963461 tgtccctgct cctggtcgct tgtaatattt tttttcaagc ccagtaaatt taaaattcgg 2963521 tctttaaaca cgatagctac tgctaaaatg gagcctagct gaataaccac cttgaatgag 2963581 ttagcagctt cttctgacat cagattactt gattttagcc agatgtcgtc tactatgatc 2963641 atatgtcctg tcgaagaaac cggcgcgtac tctgttaatc cttctacgat tcctaaaatg 2963701 gcggctacaa acaattccca tagagtcatg attttgattc tccccattag acatttattt 2963761 ttttacataa cgggagcttc ccataaatgg aaagcccgtc ttatataact ataaacgaaa 2963821 atcacacttt atgccccggc gtattttcat ttttttcttc atcgtataaa tgtgactgca 2963881 ttttaaacca gtcaaataaa tgtgtcgtaa tgactttggc aaccgcatag ccgggaatcg 2963941 caagaatgat tccaacaacg ccaaacagct tgccggctgt taacagcaga aaaataatcg 2964001 taatcggatg gatgtgaagg ttttttccca taatttgcgg agagatcagc ttcccttcaa 2964061 tcagctgaac aatcgtccaa acgatcacca gcttaagcag catgagcggc gatgtcacta 2964121 tggcaatgat aatcgcaggc gtaatggcaa tcgttggccc taaatatgga acgatgcttg 2964181 tgcaagccgc aatgactgca agcaatgaag cataatccag cccgataatc aaataaccga 2964241 taaacagcaa aaacccgata cagaagctga caatgatctg gcctctgata taagagctta 2964301 accgatgatt catttcgctt aagactgtat atgtctgttc tttcaatcga gtcggcacaa 2964361 acttcagtat gtagaccggt aattttcttc cgtcttttag caaataaaat agaataaacg 2964421 gaaccgtgac gatcgaaatg ataatctcag tcagtgcgcc gataaaattc ccaacaccgg 2964481 taaaggtgct gttcacgatc gtcgctgcct gatccgaaac ctttgtagca agatcagata 2964541 tattaatgtt catcgtttgc tgggcctgat tgacgaagtt gctgccaatc agctgtttcg 2964601 tctgattttc tacgacgtcc acatatctcg ggatattgtc aatcaaactc ataatttgtt 2964661 cttttaagaa gggaatgatc gacacgatcg tgatcgtgat cagcccgata accaataggt 2964721 atagcagcaa tatagaatag attcttctta ttcttcttct ctccagaaaa tcgacgactg 2964781 ggtttaacag ataaaaaaca atgcctgtca aaataatcgg aagtgatatc gttttgagca 2964841 gaacaataat cggggtgaaa ataaatgatg tttttgtaaa tactagaata tttaaaccaa 2964901 tcagcagcag cacaagcaaa aataaaacaa acttattatc caagaagaat cgcttgaatc 2964961 tgccgctcca tgtttgcaac gtctccacta tcgttcctcc gtcatacata gtttaattaa 2965021 attgtacact atcgtcccta taatgaaaaa taaaaaccgt taattgctgg aaaagctttc 2965081 tcggttttaa cattctattt atatctatca tgtgattttg ttctttttaa gctataattt 2965141 agctatatca tgcaaaagga gcgatacgag tgatacgttt tgcaataata ggaaccaact 2965201 ggattacaga ccgctttctt gagtcagcag cggatatcga agattttcag ctgactgctg 2965261 tttattcaag atcggctgaa cgcgctggcg agtttgctgc taaacacaac gctgcgcatg 2965321 ccttctcaga ccttcaggaa atggcggcga gcgattgctt tgatgccgta tacatagcga 2965381 gcccgaacgc tcttcacaag gaacaagccg ttctctttat gaaccatggc aagcatgtgc 2965441 tttgtgagaa gccgtttgct tcgaatacaa aagaaacaga agagatgatc tcagcggcta 2965501 aggcaaacgg cgttgttctc atggaagcaa tgaagaccac tttcctgccg aatttcaaag 2965561 aactgaaaaa acacctgcat aaaatcggca ctgtccgcag atttaccgca agctactgcc 2965621 agtattcctc acgatatgac gcgttcagaa gcggaactgt tttgaatgcg tttcagcctg 2965681 agctttccaa tgggtcatta atggatattg gcgtctattg tatttatccg gctgttgtgt 2965741 tgtttggcgc gccgaaggat gtaaaagcaa acggatatgc tttatcctcc ggagtggacg 2965801 gagaaggaac tgtcattctg tcttacgacg ggttcgaagc tgttctgatg cattccaaaa 2965861 tctctacttc ctatgccccg gctgaaatcc agggtgaaga cgggacgatt gtaatcgata 2965921 cgattcaccg gcctgaacgt gttgaaatcc gctaccggga cggccgcctt gaaaacatcg 2965981 cgatccctga tcctaaaccg gcgatgttct atgaagcaga agaatttgtc acgcttataa 2966041 aagagaataa gctggaatct gaagaaaata catttgaacg gtctttgacc accgcaaaaa 2966101 ttatggaaga agcaagaaag caaatgggga ttgtataccc tgctgatcaa gcttaaaaaa 2966161 atccgcccgc gtgcaaatgc cgcggcggat tttttattag acaatcggag aagatgcctt 2966221 cctttttaaa agcacctgtt gctcatattc tttgatgtca taaagccatg cctcttttac 2966281 cggaacgccc atttgctcac agtaggaatc ccagatggct ccgaaaggat atgttttgaa 2966341 ttcctccatc agggccagcc tttctgtata gcggccctct tcctgcaatt gttttaaata 2966401 tccgttcggg agaagcaggg catacaataa agctttgatc atatttctcg ttccgatggt 2966461 ccaggcggct acacggttaa tgctggcatc gaaaaaatcc agaccgatgg ctaccttctc 2966521 aagagcatga tttcgtacaa tttcaagagc gatttctctc aattcatcat ccaaaaccac 2966581 tacatggtcg ctatcccaac gaacaggccg cgatacgtgc aaggcaagct tgtctgtgta 2966641 aagcagcatg gacgagatct tgtttgatac cgtctcagtc ggatggaaat ggcctgtatc 2966701 aagtaaacaa agcttatgat tcgtcaaagc ataagctaaa taaaattcat gagatccgac 2966761 aacatatgat tcggagccaa gcccgaacag cttgctctcg attgaatcaa gattatgttg 2966821 ttcactgatc tcctctgaga agatccgatc cagtgattct tttagtcttt tacgcggtgt 2966881 cagcctatca ctcgggatat ccttatagcc gtcgggaatc caaatattcg tcaagcaagg 2966941 tgttcctaat tctttcccga agtattcccc gatacggcgg caagcgatgc aatgcctgat 2967001 ccaaaattct ctgatgtccg gatcagggtg tgaaagggtg agtccgtcag ccgctttctc 2967061 atgcgaaaac aaggttggat taaaatctaa accgagacca aggttttttg cccatttcac 2967121 ccagttttca aaatgctgcg gcttcaattc gtcacgttct accgcttccc tgtttgtttc 2967181 tgcgtatatc gcatgcaggt ttacgcggtg ctttccagga atgagagaaa gagccttctc 2967241 caaatctctt cttaattctt caggagtttg cgcttttccg ggataattgc cggtcacgtc 2967301 aattccgcct gaaagctcgc ccttatttac ttcaaagcct tcaatgtcgt caccctgcca 2967361 gcagtggatc gaaatgggca cttgctctaa ttgccgaagc gcctcttcaa catcaattcc 2967421 ccatttttca tatgcctgtt ttgcactgtc ataattggct tttatggtca tacggctctc 2967481 tccctttatc agtttttcaa tccaaataaa aaacttcctt tagatctatc gcaacaggac 2967541 tgaaatccga atttgttttc attaatggcg ccatcgattt ccaccatctt tggcaaactt 2967601 ccgtgtccgc catctttctc catttctctt catcctctat ttctaaatat gcaaaaagcc 2967661 tgcctgtttc ctcgtctaga aaaatggaat aatggtgtgc tccatgagct ttgagtgctt 2967721 ctgccatctc aggccaaatg tcatcatgcc gctgtttgta ttcttcgtac ttgtcttgat 2967781 ggacaaacat gatactggct tttcttttca aaccttttca cctcttcatc atttagatag 2967841 cgctttcaaa acagtttgct gaaatgactg aatgatcgtg cttctatcaa tgtctttagg 2967901 tgtaaacact ttgatcggaa aggaatttct gacgacttgc cgggcttctt ttatgtcttt 2967961 gacttctttg gcagcaatca tttgcatcaa aagatttccg gtggcagttg cctctatcgg 2968021 ccctgcatat accgcttttc cactcatgtc tgccgttaat tgatttaaga aatcattccg 2968081 ggctccgccg ccgatgatat gaaattgctc gatcggtttt tctgtgattg tttcgagctc 2968141 tttgatggct atcgcataga tgatggctaa attgctgtag atgcagcagg caagttcgcc 2968201 tgcagtacgg ggaatctttt ggcgggtttg tctgcaataa tgttgtattt cctttatcat 2968261 gttttctgga ttcaggaaac gtttatcatt taagtttata aattgctgga atggttctgt 2968321 ttttttggct tcttctgcaa gctgctgaaa agaataatct gcttgtagct gctgtttgac 2968381 ttcttgtatc acccacatgc cgataatgtt tttgagaaag cgaatggtgt tgtttgcgcc 2968441 gcgttcattt gtatagttgt tttctaaagc aagatcagtt attatcggtg ttttgttttc 2968501 aaccccgatt aacgaccatg ttccgctgct gatatacgcc cagccatcat ttacgcctgg 2968561 cgccgcaatg acggccgagg ccgtatcatg tgttgcgact gtcatcacct tgcacgccgg 2968621 gagatcataa tccgggaacc actcatttct tagcttcccg agttcacacc ccggttcagt 2968681 gagcggcgca aattgctgtt ccagaacaga cacggcttca agcaattcag gatcaagatt 2968741 tcccgttgag acgtttaaaa gctgtgttgt ggacacgttt gtgatttccg ttacagcttt 2968801 tccggttaaa caatagccta aataatcagg aatcatcata attttgtctg tctttttcag 2968861 cagctcacgg tcttcttcaa acaattgata gatcgtgttg aaaggctgaa attgtattcc 2968921 tgttttttga taaattgcgg cttttgagag ggtatgttcc agtttgtcta ttgtgtgatc 2968981 tgttcttcta tcacggtagg agattgcttc ccgcaaccga tcgccttttt cgtccagtaa 2969041 gacataatcg actgcccatg tatcaatgcc tacggtgcag tgttcatacc caagcgtctt 2969101 tactttttgc agtccttgca ggatttgttt tagcaaatga tcaatatccc ataagcaatg 2969161 cccgtctctt tgactgaaac cgttagcgaa cctgtgaatc tcttgtatgt caagcttccc 2969221 ttcattcagt tcacctacca tgattctccc gcttgatgcg cctacatcaa tggcagtata 2969281 aatcatcctt tcaccctctc ttcgaaagag gaacagctgt caccttcacc tttttgtcct 2969341 caagagcttt taccgatgcc ggatcaagtc cagaatccgt aataaggcgg ctgacatctt 2969401 gcagcgaggc gatatgtgaa aactcgcggt tcccccattt gcttgaatcg gccatcaaaa 2969461 tggtctggtc cgacctttcg atcatccgtt ttttgagcag cgcctgccac tcatttgaat 2969521 cactcatccc gttgtgtacg tcaaatccct tacatgacag aaaggtttta ttgacatgat 2969581 aggtctcaag tgaacgctct gctaacgggc cggcaaatga taatgatttt tccagcaaaa 2969641 tgccgcctgt tgaaatgact gatatgtttt ctttattgct gagttcaata gctgctttca 2969701 ttgagtttgt aatcacggtg agctcaatgt cagggagtat ttttgccatg taccaagcgg 2969761 ttgtgcttgc atcgagaatg attcggtctc cgctttttac atatttggcc gcttcgtgag 2969821 cgatggcttt tttttcgatg acattcgtga tttcccgttc agaaaaatga atttctgatt 2969881 ccttctgctg aatactgacc gctcctccgt ggctccggct cagtttatgt tctttttcaa 2969941 gcttttcaag atcacgccga atggtttcct ctgtgactga aaaaatgtca cttaattcgg 2970001 aaacgcggat gcttgaacgc atatttacta tttccactat tttttgctgc cgttctgcta 2970061 ctagcatcgg taacgccctt cctcatatcg tagtccgtct tatattttta tcatagcata 2970121 tatctaacgc gtaaaagcag cagggacgcc gccgtctacc gtgatcatgc agcccgttgt 2970181 tttttcggct ttggaagaag cgaagaatgc aatggcttcg gcaatatcct ccgggtaaat 2970241 attgacgagc aatgctgtcc gtttccggta atgttcctcc agctgatccg gttcaatccc 2970301 gtacgccgcg gctcgttcct cacgccagct tgaaccccag attgccgatc cttgaagaac 2970361 tgcatcaggc aaaacggagt tgaccctaat gccgaattct ccgccttctg ctgcgatgca 2970421 tcttgctaaa tgggtttcaa gcgccttaac agagctgtag gcagaggcgt tttttcccgc 2970481 ataaactgaa tttttcgatc cgacaaatac catgcttccg cctctatttt gatgtttcat 2970541 ctgtttaaac gcttcacggg ctacaaggaa atagcctgtt cctaaaacat tcatattaag 2970601 attccattct tttagacttg tttcgtcaaa tgggcttgat gtggccagcc cggcattatt 2970661 gacgacgata tcaatgccgc cgtaagcaag cgccgctcgt tcaaaagctg actgtacgtc 2970721 ttcctccttt gtcacatcca ttttgacagc cattgcccgt ccttttccgt atgcatcgtt 2970781 tatttccccg gcaattttct gtgcgccttc tatattcaga tcagctacga tcacgtgccc 2970841 tccctcagct gcaaatcggc ggcatgccgc actgccgatt ccgccggctc ctccagttat 2970901 cagcgctact tttcgggaaa attctgcttc cggcggggcc agcgtgagtt tatatagttc 2970961 gagcggccaa tattcgacat ggtaggactc attttcatgt aaagaaacaa attgccccag 2971021 agcggttgct cctttcatta cggcgatggc cctccgatat aaagccccgc ttactttaga 2971081 catcgcataa ctttttcctg tattcaccat tccgattcca ggaatcaata tcacccgcgg 2971141 ggcggattca aagatttgat ccccatcctg ctgattgcgt gtaaagtaag cctgatactc 2971201 tgatgtaaag gtctcgactc ctgacttgat cagatctgca agcttgtgca catcttgagt 2971261 ttccggattc caatcaatgt acagcggaac ccgttttgtg tgaacaaggt gatccgggca 2971321 tgccgcaccg atttgcgaaa gtgctggcgc ttggacactg tttacaaatt ccaagacatc 2971381 gtcatgatca tcataggaaa ggatcatttt cttttcttca cttactgctc ctctgatcac 2971441 aggcatgatg cctgccaaga tttgttttct tttatcctcc ggcagcggct gatacctttt 2971501 gcctccgaat acctcatgct gattgatacg atcgttaata tactgctcgg cttcttgaat 2971561 gatggatatc gttttttgat aacatgtttc agacgtctct ccccaagtga ctaagccgtg 2971621 tttctccatt aatacaagct cggcgtgggg gttgtttgct acgccttcag cgatcatttt 2971681 agacaaagta aatccaggac ggacgtatgg cacccataca aaccgatttc cgtaaatgtc 2971741 ttcagcgatt tgttttccat tatccgcaca gcatatgctg ataatcgcat ctggatgggt 2971801 atggtcaaca tgtttgtatg gcagaaaagc gtgtaatagc gtttcaattg aagggcgggg 2971861 atgtttgctg tctatcatac aatgagacag gtagtctacc atttcttcat cgggcatttg 2971921 gtccctttta atcagcgggc ggatatcatc taatttcaaa ccggaaaagt tatgcgcttt 2971981 cattgttgcc aaatccgatc cgcttccttt tacccacatg acttctattt cacggcctct 2972041 aaaatccttt tccgttgttt tcatagatgt attccccccg ccccagttgc agacagtgcg 2972101 gtctgacccg atcagattgg acctgtacac caattcctct acacctttag gtagctgtgc 2972161 agctcgctct gaatcccata tatgtttcac catatttgat attcctccat acccttttat 2972221 ttgtatccgt tttcattata tatgatttct gtttgttttt gaatcgtttt tgtttatttt 2972281 tgctttttaa caaaaaaaga aagcagcaga tatgccgctt tctcgtttca ttatgattct 2972341 attttaaatt tcttcgtaat gtcctgaagt tcttccgcca tgtttgccaa cgtttccgct 2972401 gaagagctga tttcttccat ggacgcaagc tgttcttccg ccgaagctgc gatatcctga 2972461 atgcctgctg agctttcttt cgccactgca gaaatatctt caacagcact tgacacttcc 2972521 tgtgatccgg ctgacagttg ttcaaccgtc gcgttcaagt tttgcaattc gccggaaatt 2972581 tgggttgtca tctcatagat ttgtttaaag ctttccgctg tttgatccgt aatctgcaag 2972641 ccttctttca cttcatgatt cacggattgg aacattgaaa gtgaggtgct gatttccctg 2972701 acaatctctt gaattaatcc ttcaatttcc ttggcggagt ctgctgattg tacagcaagt 2972761 tttctaacct cttccgcaac tactgagaaa cctcttccgt attctcccgc tcttgccgcc 2972821 tcaatcgcag catttaatgc aagcaggttg gtttgatcag caatgccgtt aatcacattc 2972881 aagatgcttg tgatgtcttg cgattttgtt tcaaggccct tcacaaccgc ttccgctttt 2972941 tgaacggatt ggtcaattgt tttcatctgg ccgactgtat gctccaccag cttttctccg 2973001 ctgcccgctg cctcagagga ctgaatcgat gatttcgtaa tggttgaaga ggcttgagcc 2973061 acttttgaaa tcccctcgtt catttgagaa agatgatttg agcttgtttc cagtttctcg 2973121 ctttgtgcct cgttgccatc tgagaactgt tcgatggcaa gtgtaatatg ttcagttgcc 2973181 ttgcttgttt gggctgcgct tgctgtcagc tcctcagaag atgaagcgac gttttctaca 2973241 gacgtttgaa taacgcctat tacagaacgc aatgatgcag acatttcatt aaagctttcg 2973301 ccaagctggc caaactcgtt tttcgagtga atgtcaatga cttctgtgag atctccgctg 2973361 ctgatttttg cagacgttga gacaagtttt cttaacggct tggtgatggc acggataata 2973421 tagagtatga gtatgccgcc gattactatt gacacgcata gaatgataac cgcagtgttc 2973481 agcaccgggc ttgaagcatc ttgcaattca ctgacaaaat atgtgcccgc gattttccag 2973541 ccagtcagtt tatttgtcgt aaaggccatt ttcttttctt tgccttcgaa tgtatattca 2973601 aatgagcctt cttttttgga atatacttgg tttgtccaat cgccggaacc ggttgtcccc 2973661 ggcttaatgg tcggatgggc gatatatttt ttgttgcctg tcgtaataaa tgcaaagcct 2973721 tcttttccga ttttgattct ttttgatgca gtaagcactt catccaggtt taaatctagc 2973781 gctataaccc ctgaaccgtc ttttaattgt tttgaaattg tgacaacgat atctcctgtc 2973841 gcttcatcgg tatacggttc tgagaaaaca gcttgtcctt tttccgcaac cgcctgtttg 2973901 taccagtcac gtcctgtcgg atcgaaacct ttcggaacac cgctatccgg atatttataa 2973961 agcttcttat cttctgaggc agcatagatt gcgcctacat cgtcgttaag tgtcgtgtac 2974021 tgcttaaatt tctctttcag taatgttttg tttttgccta acaatatgtc tttatcgact 2974081 gtctcactat aataatctat tgcttttact ttatcttcta atttattttg cagcgtactg 2974141 tttagttctt caacatttcc cttcgcactg cttatgagct ctctgtctaa cgcgttccaa 2974201 gctgattgat aactgaaata tgctaaaacc ccaaccggca aaataagcac tgccagaaac 2974261 gcagcgatta gcggtttgct gatcgatggc tgtttgatcc attgtatgaa ttttcccatt 2974321 ctcgttgact cctcctttaa gataaatcta atatcgtcaa actaggataa aaggtttaat 2974381 aaaaaaacta aaaaaaacac ccaagcgcaa caagcttggg tgttaaggct tattattcaa 2974441 ttttaaatcg tttggtcata tcccgaagct cttccgccat agaggaaagg gtctctgcag 2974501 acgagctgat ttcttccatg gaagctagct gctcttcagc tgacgccgcg atatcttgta 2974561 tatgcgctga gctttctttt gaaatcgatg caatgtgctc agacgctccc gaaacttctt 2974621 cggagctggc agaaagctgc tgaaccgtcg cactcatatt ttgcagttcg ccggcgattt 2974681 ggttcgtcat ttcagaaatg cgtttgaagc tcatttctgt tttatctgtg atgtcaagtc 2974741 ctgtctgcac ctcttgattg acagattgga acatgccgag tgatgtattg atttccttca 2974801 caatttcgat gattaatcct tcaatctctt ttgctgaatc tgctgactgt actgccagtt 2974861 ttcttacttc ttccgctaca acggagaagc cgcggccgta ctcgcctgcg cgcgctgctt 2974921 caattgctgc gtttaaggca agcaggttcg tctggtctgc gatgccgttg atcacacgca 2974981 aaatgtttgt aatatctttc gatttcgttt ccaatccgcg tacgacttgc tccgcttctt 2975041 taacggactt gtcaatgaca ttcatttggc cgacggtttg atgaacaagc ttgccgcctt 2975101 cacttgcaat ttctgtcgat tgaacagatg aatcagtgat cacttcagaa gcttgagcca 2975161 tattcgtcaa cccgtcattc atttgataaa tgtgctctgc tgccgtttca atgttttcgt 2975221 tttgtttttc attgccgtta gaaaattgtt caatcgccaa tgtaatgtgc tctgttgcct 2975281 tgctcgtttg cgcagctgat gcagtcagct cctcagagga agcggcaaca ttgtctaccg 2975341 aatcctggat ggcgtgtatg agagaacgaa gtgacgacgc catattgtta aagcttttgc 2975401 cgagctcgcc caattcatct tttgaacgga tatcaatggt ttccgtcaaa tctccctcgc 2975461 tgatccgctt agaggaaccg acaagctgtt tcagcggtgt tgtaatcgac cgaatgatca 2975521 atgtcatgac gataatccct atgataatag ctgcggccaa gacaattaaa gcaaggtgaa 2975581 ggacaggctg ggctgcctca tggatttcat ccaaatacat ggtgccgccg atcttccatc 2975641 ccgtcaactt gtttgtgtca aaggccattt ttttcttatc gccatccatg gtgtattgaa 2975701 aatcgccttt atcagcactc aacatcttat cgagccagtc gccttttaat tcagttcctg 2975761 attgttcatt agggtgtgcg acaacttttt tgtccttcgt catgataaat gcgtagcctt 2975821 gtgtgccgat gttgactttt ttggttgttt tcagcagatt ttcaatcgtc atgttgattg 2975881 cgataacgcc tgaaccatct tttgtctgct gggcgattgt cacaaccatc gtatttgtcg 2975941 acgcggtttt ataagggtct gtgatcacga ctttcccttt atttgcaacc gcttttttgt 2976001 accagtcgcg ttcaaccgga ttatagccgc ttggcatcgg aagatccgga tagcgggtaa 2976061 agtgcccttt tgtgtcactt gtataaatgg attctacatc cttgttaatg ctgatatatt 2976121 gtgagaattt ctctgcaatg cttgcattgc tttttgcatt gtatttctct tttgtcagcc 2976181 attcgctgaa ataatcagca ctgttttctt tttcgccgat gctggtgtta atgatttcgt 2976241 ttaattgctg tacattttcc aatgcgctcc ccatcatctg tctgtcgagt gagctgctag 2976301 ccgattgata cgcaaagatc gccaatatga caaccggtat gatgaggatc gacagaaagg 2976361 aaacgagaag cttccgtgta attgatcttt gttttatgag ttggagtatt tttttcatca 2976421 ttcatttctc cttttttatg ctacccttca tatcggctgg aaatgggtaa atatatacag 2976481 caaaaaagaa gaaatttaac aaaagtaact aatttcccat aaataaatag tattttagac 2976541 ctattatttg tctactttaa attgttttgt cagatcacgg agttcttcag acattctttc 2976601 aagcgtcagt gcagatgaac taatctcctc catggatgcc agctgttcct cagctgaagc 2976661 ggcgatatct tggatgccat ccgagctttc cttagaaatg gcagtgatat catttgaagc 2976721 tgcggaaatt tcttgagctc ccgctgacag ctcctcaacc gtcgcattca tgttttgcag 2976781 ctcggaagca atttgattgg tcatttgcga tatatgtttg aagctctgtt tagtttcatc 2976841 cgtcatgaca agccctgttt caacttcttt gtttacggac tgaagcacgt tcagtgatgt 2976901 gtgaatttct tttactattt cactgatcag cgattcaatt tcttttgctg agtcagccga 2976961 ctgtaccgcg agctttctca cttcctcagc gacgactgag aagccccggc cgtattcacc 2977021 cgctctggca gcttcaatgg cggcatttaa agccaaaaga ttggtttgat ccgcaatgcc 2977081 gttgatgaca cgcaaaatat tcgtgatatc ctttgatttg atctccagcc ctttcaccac 2977141 ttgttccgct gcttttacgg aatggtcaat tgtgttcatt tggccggctg ttttctggac 2977201 gagtgtctcc cctttgcttg acacttcggt tgaatctgcg gatgtttctg taatcactgc 2977261 tgcagcccgc gccagctctg ccaatccgtc attcatttca ttaatttgtt cggttgtcgt 2977321 ttctattttc tcgctttggc tttcactgcc gtttgaaaat tgctcgatag ccatcgtaat 2977381 gtgctcagtg gctctgcttg tctggtctgc cgatgcagtc agctcttcag acgaggaggc 2977441 aacgtgttct actgagtctt tgatcccgtg aatgagcgag cgaagcgagt gtgccatatg 2977501 attgaagctc tcactcagaa cgccgagttc atcttttgaa ttgatttcaa tcgtttcggt 2977561 tagatcgcct tcactaattt tttcagcgga tgcgacaatg cgtctcaatg gctttgtgat 2977621 ggatcgaatc acaaaataaa tcgccgtcat tccagctccg atggcaatcg ccagaacgat 2977681 tgaagccatg atcagaaccc tgcttgcagc atcgtgaatc tcgtttgcat acatcgtgcc 2977741 gctgattttc cagcctgttg tttggcttgt tgcaaatgcc atttttttct ttttgccttt 2977801 gtacgtatat tcaaagtccc cgcttttatc cttgtagagc ttatcaaccc agtccccttt 2977861 tagctctgtt cccgcttttt ctccggagta ggcgatgact ttcttgtttt ggctcaaaat 2977921 aaaagcatag ccttcttttc cgatattgat tcctttcgcg gtagtgacta agtcatcaat 2977981 tttcatatca atggcgacaa cgcctgaccc atccaccgtt tgacgggcga tggtgacgac 2978041 catttttcct gatgaaatcg attcataagg ctcagtgaca attgttttgc ctttattggc 2978101 cattgcttct ttgtaccaat ctcgttccaa agcattaaag tcgcttggca tgtcagcgta 2978161 cggataacgt gtgaagtccc cgtctttgcc gcttgaaaat accgcagcga cattatcatt 2978221 catttggata aattgtttaa attcctgttt cagctctgtt ttctttttat cctgaaattt 2978281 ttctgctgta gcccaatcgc tgaaatatgc gaggcttttt tcagtagtgc tgattttatc 2978341 atcaatgatg tgatctaata tctgaacatt ttcctttgcg ctttgcgtca tctgtacatc 2978401 aagtgaggca actgctgatt gataagcgct aaccgaaagg gcggttatcg gaacaattaa 2978461 gatcagcagg aaagaaataa taagtctcct tgcaattgat gatctgcgaa tagtggtgag 2978521 tgtttttttc atttcctttt gaaccttctt tcaataattt acaaattata tcggcggatc 2978581 ttcctttaaa ttacattgaa aatggaggaa aaaatgaaaa atagttctaa attcacctgt 2978641 taaactagga ctttattatt gtttaccata taaaaaaaca gcgctttgat agcgctgttt 2978701 ttcggttttt actcgatttt aaattgtttc gtcagatcgc gaagctcttc tgccatctgc 2978761 gcaagagtcg tcgctgagga actgatttct tccatggaag caagctgttc ttcagctgat 2978821 gcggcaatgt cctggatgct tgccgagctt tctttcgaca cgtctgcaat gccgctgact 2978881 gctgctgaaa catgctgtga acggtctgac agctgctcga cggtggaatt catcgtctgc 2978941 agcttgcccg cgatttcgtt tgtcatgctg aaaatgctct ggaagctttc ttttgtattg 2979001 tctgtgacaa caagtccgga ctgtacttcc tgattgacct ctttaaacat gtgaagagag 2979061 gtgtcgattt ctgcgacgat ttcttggatc agcttttcga tttctttcgc tgaatcggct 2979121 gattggacag ccagcttgcg cacctcctcc gctacgacag agaagccgcg tcctgactct 2979181 ccggcacgcg ccgcttcaat ggctgcattt agtgcaagca gatttgtttg gtcagcgatt 2979241 ccgttgatga ctctcaaaat gcttgtgatg tcttttgatt ttccttctaa gcctttgaca 2979301 acagcttcag cctgctgaac agattgatta atcgagttca tttgtccgac tgtctgctgc 2979361 acaaacttct cacccgttcc ggcgatttcc gttgattgga tagatgcctt tgtaatatct 2979421 gacgatgttt gtgagacttg ctggagtcct tcattcatta agttcagctg atgagagctg 2979481 gattcaacct tttcgctttg ctcctcgttt ccgtttgaga actgctcaat cgccatcgta 2979541 atatgctcgg tggctttact cgtctgcccg gcagatgcgg taagctgttc ggaagatgcg 2979601 gccacattgt tcaccgagtc ctgaatagcg ctgatcagag agcggagaga ttgtcccatt 2979661 tcattgaagc tttccccaag ctctccaagc tcatcctttg aatggatttc gatcgtttcg 2979721 gtcagatccc ccctgctgat cgttttcgat gattgaacaa gacgttttaa cggttttgta 2979781 atcgaacgaa cgataaacag aattaaaatt ccgcctgcca caatggaagc aatcagcaca 2979841 atcattcctg ttgtcagcac agactttgag gcatccttaa tttcatccat atacattgtg 2979901 ccggctattt tccaaccagt cagttcgttt gtagtatagg tcatcttttt atcttcgtta 2979961 ttaagagtat actggagttc accgctgtca ttcgcataca ttttggctac ccagtcgcct 2980021 gaaagctttt ctccagcctt atggttcttg tgggcgacat aggttttgtt ttttgttgca 2980081 atgaaagcat aaccttcttt tccgaccttg atttgtttca tttgttctaa caatttatca 2980141 atggtaatat ccatggcgac aacgccagat ccgtccttca gctcctgtgc aatggtaatg 2980201 accatgcttc cgtcactcgc agccacgtaa ggatctgtca cgacaatttc accgccggcc 2980261 ttcatcgcat cctggtacca aggccgttgt ctcgggtcgt atccttccgg caatttttct 2980321 tttggcgctt gtacataagt gccgttatct gcgcccccat aaattctggc tactccttga 2980381 ttaatagata catattgtga aaatttagct ttgatctctt cttgatttga tttccctttg 2980441 aatgcggatc ttttaagaga ttcactgaaa aaggtgactg ctttcgcttt ttctcccaga 2980501 tcatttgtaa cagttgtatt aaatgtatcg acactgtttt tcgcatttcc cataatttcc 2980561 tgatccagct ttccgctggc gcttcggtaa gagctaaatt ctaatataag aatagggata 2980621 atgagaatcg caataaatga gacgattaat ttctttgaaa tagacggttt cttcagccaa 2980681 ttgataaaag tcttcatgtc acttgctcct tcaggtttga tacagtatat atcggctgct 2980741 taaaaaagtt ttaaaataaa aaatggaaga agttcttttt ggctgtcttc tgccttttta 2980801 actttcattg cccaagctct ttgcatatct tataaaaaac aaggggggct aaacatgatt 2980861 attgtatcag gacaattgct ccgtccccag gatattgaaa attggcagat tgatcaagat 2980921 ctgaatccgc tcttaaaaga gatgattgag acgcctgttc agtttgatta tcattcaatt 2980981 gctgaactga tgtttgagct taaactgcgg atgaatattg tagcagcggc aaagacgctg 2981041 cacaaaagcg gggcgaagtt tgccactttt ttaaaaacat acgggaatac aacgtattgg 2981101 agggtttcac cggagggcgc cttggagctg aaatacagaa tgccgccttc aaaagcgatt 2981161 cgggacattg cagagaacgg cccgttttat gcgtttgaat gcgcaaccgc aatcgttatc 2981221 atttattact tggccttaat cgatacaatc ggagaagata aattcaatgc cagctttgac 2981281 agaattattt tatatgactg gcattatgag aaattgccga tatatacgga aacaggacac 2981341 cactttttcc ttggagattg tttgtatttt aagaatcctg aatttgatcc gcaaaaggcg 2981401 caatggagag gcgaaaatgt gatactactg ggggaagata aatattttgc ccatggtctt 2981461 ggaatcttaa acggaaagca aattattgat aagctgaatt cttttaggaa aaaaggagcc 2981521 ttacagtcag cctaccttct gtctcaggcg accagactgg atgttccgtc tcttttccgc 2981581 atcgtccgct aaaaagcccc atcgcctatt ttccggacga tggggtttca aatgcctttc 2981641 gttttcgata gaagggggct gtgccaaaat attggttcgc agcccactcc attttttcaa 2981701 ggtcatttct tgtcacgatt ggatcctggc tgctccattt gataaagcgg acaaaatagt 2981761 agcctttgat aggaaccatt gtaacttttg agtgaggcca gccttcaaat acaaactcaa 2981821 ttttccctct ttttttataa gaatattgaa gaatgttcat atctgtcacc tcagtttatc 2981881 aagttacgtt cggcaaagct cggtacgttt acatccattg attaactatc cctcatgcag 2981941 gctttccgga aaacaaaggg tgaggcgcgt gtctctttcc ctcgcttttt atttcgcata 2982001 tggacgaatg ccaagcacgc cttcattcga taaagccgca gcgtgggcgg gtgtgacaag 2982061 ccctccggct atcggcgctt gttcagcgat catgcttttg tcataaaaaa cagcctatta 2982121 tcccatcatt ttgatatagc atgtccgggt gcgaggcccg tcaaattcgc agaaataaat 2982181 gccctgccac gttccaagaa taagccggcc gttttccaca atgacatgct gtgaagctcc 2982241 gaccgtactc gacttcatgt gtgcagctgt attgccctcc atatggcggt ccagctcatg 2982301 ttcccacgga tatacctcat caaaccttct gagcatatct tttttgacgt ccggatcggc 2982361 attttcatta attgtaatgc ccgcagtcgt atgcggacag taaatcagcg ctgcgccgct 2982421 cgttatacct gtttcttgaa gaaacgcttc cacctcccgg gtgatatcta tcatttcatc 2982481 tcgtttggtt gttttgattt gcagtgtttt cagcatttgt ttctcctttc gtttgtccgc 2982541 tctcatcgct taattcgttc tgtgttcttt tttttcctgt taaaccgctc tcataaaccc 2982601 gataaaacaa aaaaactcca gtctaaggct ggagtttagc accatagata tattcttgct 2982661 tcatacggct ttaagagtac tgatgtcata tgcttgtgcg gctctgtttc aatatttgac 2982721 aagacgagtg catctgatga caatggcaat ccagagtgcc tgaacaacgc cggtgttcct 2982781 gtcagattgg ccgcaatcag tgcagtatgg ctctcgtttt tccgaagata tgcaaagatt 2982841 tgctgatctt ccggtaaaat gagctcgtat gtcccgttaa taaaaacatc atatgtttgg 2982901 cgcagcttga tcaagctttt gtaaaaatgg taaacggatg ttttatcgtt tttttgcgcc 2982961 tcggcattca gccatttgta attctcattg attccgatcc acggtttggc ctcagaaaat 2983021 ccggcgtatg gaccagcatt ccattgcatc ggcgttcgcg aattgtctct tccctttttc 2983081 cagacaatct tcatcacatc ctcgtgtgat gtgcctttcg ctgtttttgt ttcatacagg 2983141 cgtttcaatg cgacatcatc atagtcctca atagatggaa aagccacgtt cgtcatcccg 2983201 agttcctgtc cctgataaat aaacggtgtg cctttcatga gaaaataaac agcggaaagc 2983261 gcttttgcac tttctttcag gtacactccg tcgtctcccc acacagaaac tgaacggggc 2983321 tggtcgtgat tctccataaa caaagcattc cagccgatcc cttccagact gtcctgccag 2983381 tcagttaaaa ttcgtttaaa tgcaacgata tcaatacttt cattgatctc tacatcccac 2983441 aggccgagat gctcaaattg aaaaatcatg ctgaatatgc cgtttttttc tccagcccaa 2983501 tcagctgctt cttttgcagc gacgccgttt gcttcaccaa ctgtcataat cggatagcgg 2983561 gaaaatgtgt tttccttcag ctctgttaac aaatccataa tgccgtcagc attcatatga 2983621 taaggaaagg aagggacata gtccagtccc tttggattcg gcatgtcagg aaacccttct 2983681 tttttcttaa tatgcgtaat ggcatccacc cgaaatccgt caattccttt atcaagccac 2983741 caattgatca tgtcataaac ggcattcctc accttttcat tttcccaatt caaatcaggc 2983801 tgttttttat caaaaaggtg cagataatac tggcttgtct tttgatcata ctcccaagcc 2983861 ggcccgccga aaatgctttc ccaattgttg ggcgtttttc cgtttttgcc gtctttccaa 2983921 atataccagt cgcgcttttc cgagtgtatg gatgaacggg attctatgaa ccatggatgt 2983981 tcgtcgcttg tgtggttcac aacgagatcc ataatcagct tcatatccag atcatgaatg 2984041 tcaccaagca gctcatcaaa atcttccatc gtgccaaact cgcttaatat gttttgataa 2984101 tccctgatat catagccatt atcggcattc ggtgaatcat acagcgggca aatccatatg 2984161 acgtcagcgc ccagctcttt tatgtaagaa agcttggttc tgattccttg aatatccccg 2984221 attccgtcgc catttgaatc tttaaaactg cgggggtaaa tttggtaaac tacggcttcc 2984281 ttccaccaag cctttttcat acagccactc cttcccagtg taccgttctt atatatccta 2984341 tgtagaaaaa ggtctttaca gcattgcttt ttaagaaatg acttgatgac acaaaaaaca 2984401 gccgtttgtt ccccggctgt tttttatcaa aaatcagttt tttttatttc tacaaaacgg 2984461 atgtggtgat cttcggcgtc gaggatttta aattcacagc cctccgcgtg tatcacatcc 2984521 cctgctttca gctccatttt ttgcgttaga agccagcctg caatcgtatc aatttcttca 2984581 ttttcaatcg caatgtcgag aaggtcattc acttcgtcta ttagcgcttt tccatccatc 2984641 acataatggt gctcgccctt tttcaggatg tgcggtgttt catcctgatc atactcatcg 2984701 cggatttccc cgacgatttc ctcgataata tcctctacag tgacaagccc cgccgttccc 2984761 ccgtattcat cgacaagaat cgccatgtga atccgctcct tctgcatgcg gattaaaagc 2984821 tgctgaacag gaatgctttc aatgactctg ataacgggcc tcatgatttg attcagcttt 2984881 atcggctggc cgagaaaata agctttaaac atatctttgc tgttgatgat ccctaaaata 2984941 tgatccttgt catctttgat gacagggtag cgtgtatacc gttcattaat gatgtgatga 2985001 attgcctctt caagcgactg ctccagagag ataaccgcaa tttctgtccg cggaatcata 2985061 atctctctcg ctacccggtt gtcaaattca aaaatcttat ttacatagcg gaattcagac 2985121 tgattgattt ctcccttttc atagctttca gaaaggatca gccttagttc ctcttcgctg 2985181 atgacaacct gatgctcctt taccgaatga aagccaaaca atttcacaag aaaacttgca 2985241 gagccgttta atgctttaat aaacgggtac gtgattttat aaaaccagat cagcggcttt 2985301 gcaatccata agcttacagc ttcagctttt tgaatagaaa ccgttttcgg ggcaagctcc 2985361 cccatcacca catgcaaaaa agtgacgatg ataaatgcaa ctacaaatgt gacaatgtgg 2985421 ttaaacggtt ccggtatgcc tgtcattgta aataagggat gaagaaaacg ttcaaatgta 2985481 ggttcaccaa gccacccaag gccgagggct gtaatcgtaa tcccgagctg gcaggctgat 2985541 aaatactcgt caagattgga gatgatttta tgtgcggcta gtgctcggct gtcaccgctt 2985601 tcgatgagct gattgatttt tgaacctctg attttgacga tcgcaaattc cgctgcaacg 2985661 aaaacagccg taatgccaat caaaacaaaa atggcgatca attgtaaaat aagcaaaaaa 2985721 agcccttacc ataaatggta aggggccacc tccttaacgt taattctcat cacgaccgtt 2985781 taagaaaatc atcacaaaac gaagtagttc aaacagggaa accagggcgg cggccacata 2985841 cgttaaggca gcagcactca gcactttatt taccccattt tcttcattgt ttcggatgaa 2985901 tccttctgac acaataatct gcttcgcacg tgaacttgca ttgaattcga caggcaatgt 2985961 aatcagctgg aaaaagacag ccgctgaaaa cagtatgatg ccaagcccga tcaaattcag 2986021 gctgccgaga agcatgcctc ctaagaaaag caaaggagct acaccggatg caaaattcac 2986081 gactgggaag attttatgtc tcagcacaag cgcaccatat gactcctgat gctgcaaggc 2986141 atgtccgact tcatgggaag ctacggatat ggcggaaatt gagcggccgt aatagaccgg 2986201 ctcagataaa cgcaccaccc gtcttgtcgg gtcgtaatgg tctgttaaag tgcctcttac 2986261 cggttcgacc ggcacgtcgt aaagaccgtt tatatctaaa atccgtcttg ccgtttctgc 2986321 ccctgtacgt ccgcttgagg cttccacttt tgaatatttt tcaaagttgc tctttacttt 2986381 aaattgtgcc caaaacgaca atcccaatgc ggctattgtt aaaaatataa acagcatttt 2986441 ttcatcatcc tttgttcatg atcatttctc tattacgatt attttaatga gttttctttc 2986501 tcgtgtacag aaatgcgctt tttcttccgg cttggagcac acaatccaat cagcaaaaag 2986561 aacaggcctg ctgaaaacaa ataaaaggcg aaactgccgg ccagttcttt cagaaaatga 2986621 agccaggaga agcttccgga aaagtgatta tatgaattca aatcgaaaat aaacaaaatc 2986681 accgcggatg ccgccagctg cgtaccgatt aaaaccacga tcgttctttg aaagatcgtc 2986741 atctttttca tcctttttgt tttagtttat ggagaaatcc ggttttatat gttttgtaca 2986801 ttttttgaaa aacatcaccg gaagtgggac atactgttag aaaaaagcac gggtgtgatg 2986861 gaagctatga aagtgacgag tgaggaaaag gaacagctga gcacagcaat cgaccgaatg 2986921 aatgaaggac tggacgcgtt tatccagctg tataatgaat cggaaattga tgaaccgctt 2986981 attcagcttg atgatgatac agccgagtta atgaagcagg cccgagatat gtacggccag 2987041 gaaaagctaa atgagaaatt aaatacaatt attaaacaga ttttatccat ctcagtatct 2987101 gaagaaggag aaaaagaatg aaatcaaatc ggatatttat ttcatggctc aggtggccgt 2987161 tatttatccg aatcggggtt attattttat gtctgattct tttgttcggc caaatcattt 2987221 atatacttga gcctaagcag ttcacttcgg tattcgaagg tatttggtgg gctgtcgtta 2987281 cggtttctac agtcggttat ggagactatg tgccgcacac tccgctggga caggcagccg 2987341 gaatactgct gattttgagc ggagcaagct ttgtcacagc gtatttcgct acgttatcag 2987401 cggccgcatt cagcagacag catcgctaca ttgaaggaaa agttgcttac aaaggccggg 2987461 accacatcat tctgatcggg tggaatgaaa aaacaaaccg gcttttgaag gaccttcagc 2987521 ttgccgcccc ttccaaaaca gtcgtactaa tcgatgaatc cttaacagaa ggcccgctta 2987581 ttgaaaacgt tcatttcata cgcgggcacg ctgccgatga tgggacactg aaacgggcca 2987641 atattactga agcggaatca gtgatgatta ctgccgatca gtataaaagt gaaactgatg 2987701 ctgatatgct gtcagtgctg actcttttat ctgttaaagg tcttaatccc cttgcttact 2987761 gcatcgtcga gattttaact gaccgttttg tcaccaatgc ggaacgggca ggcgcaaacc 2987821 aaatcatcgg aacttcagaa tttatcagcc gggcgatgct gcagcattac caagtcaagt 2987881 tacggccgtc taaacagcag aacggaatca agctgacact tgatcagcat gtggagcttc 2987941 ttgctgttcc tgacgaacta aagggagcgg cttacaaaac ctgtgttctc tatttccttg 2988001 atcacaacac aacaattata ggcatacaaa aaaaggaggg gccgatgctt tcccctcctc 2988061 ttacatacaa ggtgctcgaa acagatcaat tccttgccat ctagtgtaac agaacatcct 2988121 ccaattcttt cacgagagag gcgccgatat ccaaaaatgc cggatcaatt tccgcgtccc 2988181 gcctttccgg ttcggaaaat tgattaaaca gtgattggaa aggccctccc tcggcgtgat 2988241 cgtcaacatc cgcctgaaac acctgtctca gcataaatgg cgttccgatc cggacggccg 2988301 cccctcgttc atcgagactg ccctgtaccg cattgacggg aattcttaaa aataaatagc 2988361 cgtctctatc atcaatttta taatcaaagt agccatgatc gtattcccag ccgccgttta 2988421 tcacataacc gagcggcttc atcacttgtt ccagttcttg aagcagaaaa gactgcccat 2988481 ctatcgcgga aggtattggt atcatcagaa tgcccctttt ttcacttatc ctgtcccgcc 2988541 gaacaagact tcattcagag gcgcctacat ggaaatcgtt gtttctttcg cgcggccaac 2988601 aggaaagaaa gcgcattcaa ttaagaagta aacagccatt gccgctgcaa gccatacagc 2988661 tgaatcccaa gacacataaa caaccgttgc atagagtcct aatttagtga aaagagtatg 2988721 ggttcgtttt aaatgcaaaa tccgatgtac cgcatcggta aaaagggcaa gcggcaaacc 2988781 aatgagaaga aaggagtgga tgaaaaaatg tgacagcgtg ccgccaaagc ttgaagaaaa 2988841 ccctgtatac acggcatcaa aggagataag gaaacttaaa atagctgcag aaaaaccggc 2988901 aatgatgaga tgtttaacca attgtttcat gaacatcagc acctttctga ttttataaaa 2988961 agccgaccgg caaatgccag tcagctttct cacattaatc ttccagacgt ttttcaagct 2989021 ctgctttttt ctcttcaaag ccaggtttgc cgagtaacgc aaacatattg actttatacg 2989081 cttctacacc aggctggtca aacggattga cgccaaggag gtaaccgctc atcgcgcagg 2989141 ctttttcgaa gaaatataca aggtatccaa aagtatatgc attcagctca ggaatgttaa 2989201 cgattaagtt cggaacattt ccgtctgtat gggcaagcat tgtaccttgg aatgcttttt 2989261 tgttaacgaa atcaacagtt ttaccggcta aatagttcaa gccgtcaaga tcgttatccg 2989321 cttcctcaat tgtcagttca tgtttaggct tctctacgtt caggaccgtt tcgaataaat 2989381 ctctgcggcc ttcttgtaca tactggccta aagaatgaag gtctgttgaa tagttcgctg 2989441 aagaaggata aatgcccttc tcatctttcc cttcgctttc tccgaacagc tgcttccacc 2989501 attccgcaaa gtattgaagc gccggttcgt agttgatgag catttcaatt gttttgccct 2989561 tattataaag gacattgcga acaaccgcat attggtatgc tgggttatct tccagttcag 2989621 atgttgcaaa atctttgctc gcatccaggg cgcctttcat catgtcgtca atgttgacgc 2989681 cgctgacagc aatcggcaag agacctacag ctgttaaaac tgaataacgg ccgccgacat 2989741 cgtcaggaat tacgaatgat tcaaagcctt cttcgttaga aagcgttttt aatgcgccgc 2989801 gctctttatc agttgttgca taaatccgcg ctttcgcttc ttctttaccg tatttctctt 2989861 caagaagctt gcggaaaata cggaaagcga ttgcaggttc agttgtcgta cctgatttag 2989921 aaatcacatt aatagagaag tcaacatctt caagaagatc catgacgtct ctcatataag 2989981 atgaactgat gttgttcccg ataaaaatga cttgcggatt gccgcgtttt gcttttggca 2990041 aagtgttata aaacgcgtga ttcagcgctt caatcgctgc ccgcgctcca agataagaac 2990101 cgccgatgcc gacaacaagc aagacatcag agtcagattt gattttttcc gcgctttttt 2990161 tgatgcgcgc gaattcttct ttatcataat gttcagggag gtccacccag cctagaaaat 2990221 cgctgcccgc gcctgttttc tcatggatat tatggtgtgc tgtttttaca aagtcccgca 2990281 ggtatgtaag ttcatgttcg ttgaagaaag tcaacgcttt tgagtagtca aagcgtacat 2990341 gcgtcattgc ttgtccctcc ataacggtat aatgttttca tctttcactt tatatgaact 2990401 tatctgtgaa atcaagtcaa gaagaaaggg cggaatgact ggattccgcc ctttgggttt 2990461 atagagacgc gcgaaggatg gcaagcacgt catctttgtt cagtttttgg aagttgccga 2990521 agccgccgtg ttccatttcc ttggctgcga tatcagcaat cagctcaagc ttttcttctc 2990581 caatattgta atcagcaaga cgagaaggtg caccgaggct tgtccagaac gcagacagtt 2990641 tatcgattcc ttcaagcgca atttctttat ctgttttgcc ttcagtatca atgtcaaaca 2990701 tgttgagcat aaggttttta aaacggccta catttgtatc aagcgtgtat ctcatccaat 2990761 ttgggaacag tattgccaaa ccgcccgcgt gcggaatatc atatacagct gaaacagcgt 2990821 gttccattgt atgagaagcc cagtcaccga agtatcccat ttggagcgtg ccgtttaaag 2990881 caatagtacc agcatacaaa atcgtttcac gaagttcgta gttttccaga tcttcaagaa 2990941 gcttaggagc tgtttcgatg accgtctgca aaacagcaaa gcacattcta tcctgaagcg 2991001 gcgtgttttc aacattatgg aagtattgtt cgaatacgtg gctcatcatg tcaaccatgc 2991061 cgtatactgt ttgattttct ggaacggtga acgtattttc agggtctaaa atagagaaac 2991121 gcggatgagt gacattgctg ccccatacaa atttctcgtt tgtttcccag tttgtaatca 2991181 cggaatcagg gttcatttca gaccctgttg cagcaagagt taaaacagtg ccaaacggca 2991241 gcgcatcctc cgctgttact tttttgctga aaatatccca agcgtcaccg tcatatttga 2991301 cgccagctgc gattgccttt gtacagtcaa tcacactgcc tccgccgaca gcaagcagaa 2991361 aatcaatgtc atgctctctg caaagtccta tgcctttttc cactgtcgca agacgcgggt 2991421 ttggctctac acctgacagc tcatgaacaa cagcgccctc ttcttttaaa atgcctgtga 2991481 cttgatcata aaggccgttg cgtttaatgc tgccgccccc gtaaacaagc agtacattct 2991541 tgccgtatcg tttgaattct tttcttaatt gttcaagctg accttttcca aaaatcagct 2991601 ttgtcggatt ataataagtg aaattttcca tagtaaaacc tccaaatgat gctggtaaaa 2991661 aacagatttt ccattgtaac ataagttgac aaaaaagaaa aagggaagca gccaaacggc 2991721 tatttcccct ttttttatag tgatgctttc aaaattgaca gcacatcttc tttgttgagt 2991781 gatttaaatt ggccgaatgt accgttagcc attgccttgt cagcgattgt gtcaagctgc 2991841 tcatcattaa tatcataatc agcaagacgg ttcggagcgc caagacttgt ccagaatgcg 2991901 gacagcttat cgataccttc aagggcaatt tcttcatccg ttttacctgc ttcttcaaca 2991961 tcaaacacgc gaactgcaag ctgtttcatg cgggcagggt tttcagacaa tgtgtgtctc 2992021 atccaattcg ggaacagaat cgccagtccg ccggcatgcg gaatatcata aacggctgat 2992081 actgcatgtt caatattatg agtagcccaa tcccctcttg cccccataga aagcatgccg 2992141 tttaatgcga ttgttcctgt gtacaggatc gtctcacgca attcgtaatt ttcgagatca 2992201 ttgatcagct taggcgctgt ttcaatgact gtacgcaaaa gtgattcaca catgcggtcc 2992261 tgatacggcg tgtttgatac atgatggaag tattgttcga atacgtggct catcatgtca 2992321 accatcccgt agatcgtgtg gtttttaggt acggtgaatg tattcaccgg atcaagaatc 2992381 gagaatttag ggaatacgag cgggctgccc cagccgtatt tttcttttgt ttcccagttt 2992441 gtaataacag atcctgagtt catttctgaa ccagttgcag cgagagtcaa taccgttccg 2992501 aatggcaaag catcttttgg ctgatgcttt ttcgtaacga tatcccacgc atcaccatca 2992561 tacttcgctc ctgcggcaat cgcttttgta cagtcgatta cgcttccgcc tccgacagcc 2992621 agcaagaaat caatgttttg ttctttacag atggcaacac ctttattaac agtcgacaca 2992681 cgaggattcg gttccacacc tgctaattca tgcacggtcg ctccggcttt attcagctgt 2992741 tcaatcactt gatcatacag gccgctgcgt ttaatgctgc cgcctccgta cacaagcaat 2992801 acgttttttc cgtaaggttt gagttcctcc ggaagtcttt ccacttcgcc gcgcccgaaa 2992861 attaatttgg tcggattcca gtatgtaaag ttttgcatga catctcctcc ttagattttt 2992921 tattatgcag aatgtcctca ccacatgtaa agcaatcagc tctcaccgat cagcatacca 2992981 gatggtttta ttttgcaagg tgctgggaaa gaagctgata taagcgaggg caggccagct 2993041 tccctcatat ggagaatgca tgtatagatt ctccaatatg tcacaatcta taactgtttt 2993101 aataattcat ggaggaggtt gcaaaacatg agtaccattc aaagaatttg tcttgtatta 2993161 accatcattg gcgccattaa ctggggactg atcggatttt tccaatttga cttagtagcg 2993221 gctatcttcg gcggccaagg gtcagctctt tcccgaatca tttacggact tgtcggaatc 2993281 gccggcttaa tcaacctcgg tctgctattt aagccaaacg aggaaagatc acgtgaagaa 2993341 gcagcaaatc ctgaaatgcg ataggatatc aatcacgctg aaataggatt ttgcatgaaa 2993401 tcaaaagcac cgaacattcc tgtccggtgc ttttttcatg cttatttttt gataaggtct 2993461 ttgcggttgg acatttcgat ccactcttca agcttatctt ttaatgtgtt gaaaccttgt 2993521 ggtgtagaag cttcttcgct tacttgagca gctttaggtt ttcttggttt gctttctttt 2993581 ttctcaggcg cagcttgtgt cgcacgaatt gaaaggctga ttttgccttt ttcttcatca 2993641 acagcaagta cttttacttg tacttcgtcg ccaactgaaa ggtgctcgtt gatatctttt 2993701 acgaaaccgt gagtcacttc agaaatgtgt actaaacctt gagtttcttc atctaatgca 2993761 acaaacgcac catacgcttg taatcctgta actttaccag tgtaaacact gcccacttca 2993821 aattttgctg ccattcataa caactcctaa gttaaattaa atatctgttt atacgcaatt 2993881 taaaattata tcacacatgt cttatttccg caaagaaaac ttttttataa aaaatcaggt 2993941 ttatgcacag caaaaagggg gtaaactgaa aataccaaag gctttctagt attcccccct 2994001 tttattggat gcgaacaaaa ggttcgtatc tttttttatg ttgttttgtg caggaagcgt 2994061 ttcattctga ctaacgcttc ttgaagctgt tcaatcgagg ttgcgtatga acaacggata 2994121 tatccctcac cgctcggacc aaacacactt ccaggaacaa ctgccacttt ttcctgcgtc 2994181 agtagctcct cggcaaactg ttctgaactc attcccatgc ttttgataga tggaaaagca 2994241 tagaaagcgc cgcccggatg atgacagctg agaccgattt cattgagcga ttctacaaac 2994301 agattccgtc ttcttcgata gctttttttc attttttcta cgtcttccat gccgttcttc 2994361 aggccttcaa gggcggcaaa ctgcgccatt gcgggcgcgc acatcatcgc atactgatga 2994421 attttaagca tggcatcccg aagcaaggat ggtgccgcgg caaaaccgag cctccagccc 2994481 gtcattgcaa atgcttttga aaagcctgag atgactaccg tccgttcctt cattcccggt 2994541 aatgccgcta tacttgtaaa ttcctcatca tatgtcagct ccgcgtagat ctcgtcggct 2994601 aagacgatga catcatgttt tttggcaaac tcagcaatct cattcagctc ttccttcgaa 2994661 taaaccgaac ctgtcggatt cgatggtgag cagatgagaa tggcctttgt tttttcagtg 2994721 actgccgctt caaaatcagc agccgttgct ttaaatcctt tgtctgccgt tgtatgaacg 2994781 tgaaccggga taccgcctgc caaagaaaca agcgcatcgt acgcaacaaa acacggctca 2994841 ggaatgatga cttcctcacc tggattcaca atggcgcgga tcgcaatatc caaagcctga 2994901 cttgccccca ctgtcacaat cagctcatta tctggcgagt agctaaggtc aaacctgttg 2994961 ctcaaataac ggctgatttc ctcccgcaat gagtataaac ccgcattggc cgtgtatgac 2995021 gtatatcctt gttcaagaga gagaatgctt gcttcgcgga cattccatgc ggtaacaaaa 2995081 tcaggctcgc cgacgcctaa agaaatgacg ccttccatcg ttgccgccaa atcaaagaat 2995141 ttgcggatgc cggatggttt tatttgttgt acatagtctg ataaatacga agtcatttac 2995201 ggtgacacca cgattctttt gtcgtcgtct cctgtttcaa acactttgcc gtcatgcttg 2995261 tattttttca ggataaaatg ggttgtcgta gatacaactg aatcaagcgt tgagagttta 2995321 tccgaaacaa aacgcgctac gtcagacatc gaattgccgc gaatcacgac agacaaatcg 2995381 tatacgcctg acatcaggta aactgattca acctcttgga atcggtaaat ccgttccgcc 2995441 acttcatcaa aaccgacgcc ccgcttcggc gttactttga cgtcaatcat ggccgtaacg 2995501 ccctcatgtc cgtcgacttt tcgccagtca atcatagcgg aataatcgat aataaccttt 2995561 tctttctcca gtttgtcaat aattgttttc acttcattta cagggatgcc cgccatcttt 2995621 gcgattgttt ctaaatcggc gcggctgttt tcgtctaaaa tttctaatat ttctgtttct 2995681 ttttctgtca atttcatttg attcacacct ttgcaatgtc aagaaatctc atgacattat 2995741 atcacgtttt ttgacgaatg ctaagaaaaa acgaggagaa acttccgcta gaattgacaa 2995801 tttcagggca taatacaacc atcaaaaaaa gggagtgaca cagaatggag gcggtttcac 2995861 caataaggcg gtttacggtc gatggagtca atgtatacta cgaacattat caaaatcccg 2995921 gcaggcaaac gctggtctgc gtacacggtt ttttatcatc tgcattcagc ttcagaaaag 2995981 taattcctct ccttcgggac aagtacgaca tcatcgcgct tgatttgcct cctttcggcc 2996041 aatctgaaaa atcaagaacg tttatctata cctatcaaaa ccttgctaag cttgtcattg 2996101 ggattttgga gcacttgcaa gtgaaacagg ctgtgcttgt cgggcattct atgggcgggc 2996161 agatatcgct gtctgctgct ctccaaaaac ctgagctttt ttcaaaggtt gtgctgcttt 2996221 gcagttcagg gtatttaaaa cgttcacacc cgacgattat tttcgggacc catatcccgt 2996281 attttcatct ttacatcaaa cgctggctct cgaaagaagg cgtgatgaaa aatttattaa 2996341 atgtggtgca tgacaaatcg ctgattgatg aggagatgat tgacggctat ggcagaccgt 2996401 ttcaggacga gcagattttc aaagccatga caaggtttat ccgccacaga gaaggagatt 2996461 tagaacccga gcaattgaag aaaatgaaca agcctgctct attgatttgg ggcgaggagg 2996521 atcgaattgt cccaatggag atcggtaaac ggctgcacgc agatttgcct aattccgtgc 2996581 tgtactcact tggccagacc ggacatctgg tgcctgaaga acggcctgaa cttatttctg 2996641 aacacattgc tgattttatc aaataacaaa aaaaccggtg ctgaaccggt ttttttaagg 2996701 cgtgcaggag ctgctgtttt taatgaataa aagctggcca gccacttccc ggcagctggc 2996761 gatcggcagc gtttgttcaa aagaagtttc aaatatttgc tgaatgcttt tcgccagcaa 2996821 gtcgggatcg ttttcatcat agactgcctg cacgacatca acagcctccg tttcgtaaaa 2996881 ctcttctcca tatttaaacg ggtcccattt ggcaatgatc ttaatcattt ccctgaccgc 2996941 atgactttct tccatattca tcaccgctta taataaaatt tgcagttcta tcttatcata 2997001 gtgaagctta gaagaataaa catacatgag ggggtaacag aatgaacttt gataaacgag 2997061 aagaacgcct tggcacccaa tcggtcaaat gggataaaac aggcgaatta tttggcgtga 2997121 cagacgccct cccgatgtgg gtggcagata tggattttcg cgccccggaa gcgataactg 2997181 aagcgttaaa agagcgtctt gaccacggta tttttggtta tacaactcca gatcaaaaaa 2997241 cgaaggatgc tgtgtgcgga tggatgcaaa acaggcacgg ctggaaggta aatccggaaa 2997301 gcatcacatt cagccccggc gttgtaacag ctttgagcat ggcggtacaa gcttttacgg 2997361 agccgggcga tcaagtagtt gttcagcctc cagtttatac gcctttttac catatggtgg 2997421 agaaaaacgg ccggcacatt ttacataatc cgctgctaga aaaagacggc gcatatgcaa 2997481 tcgattttga agatttggag acaaagctta gtgacccaag cgttacattg tttattttat 2997541 gcaatcctca taacccttct gggcgttcat ggagccggga agatttactg aagctaggcg 2997601 aattgtgcct tgagcatggc gtcacagttg tatcggatga aatccattcc gatttaatgc 2997661 tgtacggaca taaacacacg ccgttcgctt cgctctctga cgatttcgct gatatttccg 2997721 tgacatgtgc tgctccaagc aaaacattta atatcgccgg attgcaggct tcagcgatca 2997781 ttattccgga tcgcctgaag cgcgccaagt tttccgcaag ccttcagcga aatggtttag 2997841 gcggactgaa cgcgtttgcc gtcactgcaa tcgaagccgc gtattcaaaa ggcggaccgt 2997901 ggcttgatga attgatcact tacattgaga aaaacatgaa cgaagcggaa gcctttttga 2997961 gcaccgagct gccaaaggtc aaaatgatga agccggatgc atcatacttg atttggctcg 2998021 acttcagcgc ttacggcttg tccgatgcag agcttcagca aagaatgcta aaaaaaggaa 2998081 aagttatttt agagcccggg acgaaatacg ggcctggcgg agaaggattt atgcgcctga 2998141 acgccggatg ctctcttgca accctgcagg acggcctgcg ccgcatcaaa gccgcattat 2998201 cgtaaatata gctgtaaacg cctttacgtc ttcatttgta aaggcgttct taataaagga 2998261 attttatatt ttacttctaa tatttagtgt tataatagat tcatatttta tacgaaagga 2998321 tttcacacga atggaaattc taaaagacta tcttctgcac atctgcttta ttttgtttcc 2998381 tattcttctt taccaagtgt tttggcttgg aaaacctgcg attcttgtgc caaaaataaa 2998441 cagcggtttg gtcacgctct tcgcctgcgg cgcctccgtt ttatgcatta ttttcccgat 2998501 tcatgaaatg gactacatac aatacggcct tcagatgatt cccgttatca tttgtttatt 2998561 ttacattagt accgcttccg gacttacagt cgccgcatct gtcctatgtt ttgaactgct 2998621 tttttacgaa ccttccgcaa tgtttgtttt cactttgctg ccttttctta tcattatccc 2998681 aatcttattt cagaaaaaat ggccattcat gtccaaagcg aaaaaactgc tgctgtcttt 2998741 attgatcagc tgcgtggaga ttttcctatt tttcgcctca agctggattc tttccgcctt 2998801 gaatatttta aattttcaaa aatcaggaat tttcgtttac gaggcggcag tctcagggct 2998861 tttccgctcc agtgttcttc tattaagcat ctatattatc gaaagcatcg ccgaaaatat 2998921 cgccctgcgt tcacagctta tccattctga aaaaatgacg attgtgagtg aactggcagc 2998981 gagcgtcgcc catgaggtca ggaatccgct gacagttgtc cgcgggtttg tccagctgct 2999041 ttttaatgac gaaaccctac aaaacaagtc gagtgcggat tacaaaaagc ttgtactgtc 2999101 agagcttgac cgggcgcaag gcattatcac aaactatctc gatatggcca aacagcaatt 2999161 atacgaaaaa gaggtttttg acctatctgc ccttatcaaa gagacaagct cccttatggt 2999221 gtcgtacgcc aattacaagt cagtaaccgt cgaggctgaa acagaaccgg accttttgat 2999281 atacggagac gcaacaaagc tgaagcaggc tgtcatcaac ctgatgaaaa acagtattga 2999341 agcggttcct cacgggaagg ggatgatcca catatcagcc aaaagaaacg gccatacgat 2999401 catgattaac atcacagaca atggggtcgg gatgacagac catcaaatgc aaaaactcgg 2999461 cgaaccttat tattccttaa aaacgaacgg aacgggactc ggcctcaccg taaccttttc 2999521 cattattgaa catcatcacg ggaccatttc atttaacagc agcttccaaa aaggcactac 2999581 ggtgaccatt aagcttcccg ctgatcttcc tcactagcaa atcgattgga actttaatag 2999641 aataaatgcg aggtgatgac agatgagcac gtttgagaca ggctctatcg ttaaaggatt 2999701 ttacaaaaca ggtgtataca taggagaaat cacggcttgc aggccgcagc attatttagt 2999761 gaaagtgaaa gcggttctta cccatcccgc tcagggagac cttcatcatc caaaacaggc 2999821 ggatgtgcca ttttttcatg agagaaaagc gctcgcatat ggtgaacaga ccaatatccc 2999881 ccaccatatg gtgaagcctt atgacggtga agtgccggat tataccgaat ctctgcggga 2999941 ggcgacagca cagatgagag ccaaattgaa tgaggatggt tcggagtggg caaagcgctc 3000001 ccttcataat ctggacattt tagaaaaaga atattttaac cggccataac ccagtctgac 3000061 aaaagattgg gttttttacg tcgcgcgctt caacagttcg gttaaatcga ttctctcgcc 3000121 gattgtgggc ggttttggct tttcgagata ctgcttatcc tgctcaacaa gcttaaaaag 3000181 tttatatgct gtgagagcat catcaagcgc tttatgatgg gtgccggttc cggaatctcc 3000241 atactcttcg gcagctttcc ataaacccgt caatgtccgg tctccaaaaa agtttttgta 3000301 ttcaagcgat aaatctctca tttctccctt aaacgggaaa gggatatggt taaacataca 3000361 gttttgcttc agcactttca tatccatgtt tccccacgta ataattgtgc tgtttttctc 3000421 aggatccagc tcgtttagtt tacggatgaa atcctcgaat ctcattcctt cgtctacctg 3000481 tttttgggtt atttttaaaa atgatttgca gcgtttcgta agcttcggga actttttcgg 3000541 tctaacatag ctagaaaacg tctcaaccac ttcatcatca atcgacttta caattccggc 3000601 ttcaatgatt tccgggaaga agttttgagg actgtacttt ccatcaggca ttgtaaattc 3000661 gaaatcaata atgagtaagc tgtttgtcgt caccttttac acctgccttt cctccgatca 3000721 gaaaatgcta tctttatagt atatcaattc cccttctcga catttcttca ttttctaaaa 3000781 ataatgaatt ttcccagccg cttcgtttct tttaaattgt gaatcgtttc tttataatta 3000841 gtaaggaacc cgaaataata agaaggtgat gttatttcta tccgtaagaa aaactttgtc 3000901 attgtgtggc tggcgaactt ttttgtctcc gctagcacaa cgatgatcgt tccttttctc 3000961 tccttataca ttgagacgct cagctctttt tcaaacggct ttgtgcaaag gtggagcggc 3001021 tatgtgttcg gcattacatt tctcatggcg tttttggtat ccccgttttg gggacggttc 3001081 ggagacaaac gcggatacaa gaaaatcctt atggcaaccg gaacaggcat tgccctcagc 3001141 attttcttca tgggctttgt tacatcggtg taccaattgt tttttctgcg tatggcaatg 3001201 ggtcttgtaa ccggattcat cccgacatct cttgcgatga tttcggcaca gactccgaag 3001261 agctcagctg gcaaaacact cggcacgctg caaatggggc aagtgtccgg aagcttgttc 3001321 ggcccgcttt tgggaggcat gcttgctgat cgtttcggct ttacgtatac cttttttatc 3001381 acatcctttg tgattttctc gtctgttctt ctcgtgttat ttggtgtcaa agaaaagcat 3001441 cttgcagaga aaacagccaa acgtacgtct tactcgagaa aagaagtgct ctcctatatt 3001501 tttcaccatc cggcgctgtg ggtcatgatg ctgttaacca tgctgattca aacaggcaat 3001561 ttcagtatcc agcccctgct cgctttatat gtaaatgagc tgcacggacc tgtcaatctt 3001621 gcctttttct ccggcatggc attttcagca acggggctcg gaagtttgct gctggctaga 3001681 aaatggggtg atctgggcga ccgctacggc caccgccgca ttttaatcgg acttttgctc 3001741 gccgcctctt tcttttttat tccgcaggcg ctcgcgtcct cactcagcgt gctccttgtt 3001801 ttcagatttt tattcggaat ggcgatgggc ggtttgctgc catgcattac ggcagcgatc 3001861 cgcgttcagg ctcccggcag cattcaaggt gaagttctcg gctacaatgt cagctttcgc 3001921 tttttaggaa acgtgctcgg gcctctgctc ggcggaatca tatcgagcca ttttaccatt 3001981 tcggccacct tttacgtcac ggcgtttctc tttttcgccg gcgcctgcat gctttggatc 3002041 atgcagaaac ttcggaaaga ttcttatgcc aaagcaagct gattccgaga aaaaactaag 3002101 gaatcttcta aatttaacct tctcgtaatc tcaaaagaat ggtacgatat ggctagaatt 3002161 taggagaaaa gagagtgacc atgttacgaa aaataatcgg atggattttg ctcctttgca 3002221 taatcccatt gtttgcattt acagttatcg cttccggaaa agaagtaaaa caaatgaagt 3002281 ccctggatca ggtgcttgat aaaaatattg atctgaaaga tatcagcctt gttcagaaca 3002341 gctacatgta tgacagggac ggctcccttg tctcggaaat cgtcagcgac cacgaaaacc 3002401 gtgtgctcgt tccatttaac aagattcccg aggaagtcaa acagattttc ttaacatctg 3002461 aggaccgcca tttttacgag cataaaggct ttgactttat gggaatggtg cgggctactg 3002521 cttctaacgt aaaagacaag aaaattgacc agggtgccag caccatcaca cagcagcttt 3002581 caagaaactt gtatttgagc cacgaacgct ccttcagccg caagctgaca gagctcgcgt 3002641 attcctatca gctggagaaa aaatatacga aaaatgaaat tcttgaagct tacttaaata 3002701 ccatttattt caacaacggt gtttacggcg tcggttcagc agctcaattc tatttcagca 3002761 aaccgctgaa atctctcaca gtgggagaaa tggcttttat ctgtgctata cctaataacc 3002821 ctacattata tgatcctctc aagcattttg actacacgaa aagccgtcaa gaacgtttac 3002881 ttaaagggct aaaagatgcc ggggtcatta cggacaaaga gctgaaaaaa gccgtaaaac 3002941 aaaaaatcaa actggatgtt gaaaaaagag aagacaaata tcctgactac gtttcctacg 3003001 tcaatgatga attcactcag ctggtgtctg aatcagaagg ctttgataaa cgccttcaaa 3003061 aagcatcagg aaaacaaaaa gaaaagatcg agaacgagct gtccgcaaga gtcagcacgc 3003121 tgatgaaaga cggagtgaaa atttatactg cacttgatcc gtacatgcaa aatcaagttg 3003181 tggcacaaat gaattccaag ctcccgtatg cggacgtaca gggcggagcg gctgtgatta 3003241 atcaccagac gcatcaaatc attgctctat ccggcgggaa aaactatcaa aaatatgact 3003301 ttaaccgcgc ctaccaggcg tacaggcagc cgggttcatc cattaagccg cttcttgatt 3003361 acggccctta tattgaacag accggcgcga caacaagcag caccattgat gccagcaagt 3003421 tttgcagcaa agactactgt ccgcaaaact acaataaccg cacttacggc acagtgacgc 3003481 ttgatacggc gtttaaaaat tcatataata ccccggctat tagaatgctc gaccgcgtcg 3003541 gcatccaaaa ggcattcagt tatattgagc cgtatcattt tgccaaactt gtcgacagtg 3003601 actatcttct tccggcggcg cttggcggat ttacaaacgg catgacgcct cttgagatga 3003661 caaaggctta tacgacattc ggaaacagcg gaagctatac gccgagccat gcgattacaa 3003721 aggtgacaga ccttaaagga aaaacacttt ataaatggaa tgataaagcg actcaaatat 3003781 tcagcgtccg cacgaacatg cagctgaaaa aactgatgtc ttccgttgtg aaaagcggaa 3003841 cagggaaaaa agcatatttc aatgcgcctt acatcggcgg taaaaccgga acatcaaatg 3003901 attatcacga tatgtggttt gtcggcctga ctgatacgta tacaatgggt gtctgggtcg 3003961 gaaaggatac accgaccagc gttgaatatc ttcacagcat cagccctcag ctttccatct 3004021 ggaaaggaac gctgcaagcg gcttattaaa ggatcggagg ggatatggag tgacttcaga 3004081 acaaattcca aatcgcgttt tgctgtttga cggtgtctgc aatttatgca atggcgccgt 3004141 gcagtttatc attaaacgtg atccggacgg attgatttct ttcacatcgc tgcagtcgga 3004201 aacaggacag agcctgctga aaaaaagcgg gcttccgact gatcggtttg acagctttgt 3004261 ctttattgaa gacggccaag tgtacacaaa gtcaactgca gccattaagg ttttcaggca 3004321 tctgcgaggc ccatggcggc tcttcgtcct ttttttcgca gtgccgaagc ctgtcagaga 3004381 tatggtctat tctttcattg ccaaaaaccg ctataagtgg tttggcaaaa aaaatgaatg 3004441 tatgctcccc tccccttcca ttaaaaaaag atttttaccg taaataaaaa atggctagga 3004501 agctagccat cacagattgt tgacaaaatc ctaaaacggc ttcgttttag gattttgtca 3004561 tctattcagc gtgattgaaa acttttgaag ttgtgaaacg gcggaaacct gagaatctag 3004621 ccgccgtttc attgcgtaca gagcacgaag cgcaaatctg accaccaaac gctgaaatgg 3004681 ctagcttaca caggtaagct agccattatg ctattataaa gcttgataaa tatgaacaga 3004741 ataccgataa caaaggtaaa ccaaaacagc agttccaata gaatgaatcc aactaatgac 3004801 atgagagaaa gcgtcgaata aatccggtat acggtaaaca caaagtaagc gagcgtgacg 3004861 accgcaaacc agatcacaat ccaaatgaca ttttgcaaga gcacaaagga taaaatcccg 3004921 ccgcccaaat aaatcatgga acccattctg agttttttca ggttgttccc ttccggatca 3004981 ttagcaaaaa acagcaatga cagctcggtc acggtatttg caattaattt cagagcggac 3005041 agaaccataa aatataaaag tgcaaaggca gcaaataacg caagcctgat tcctttctct 3005101 gaaaaataat cgagcattcc atcatacatt ccaaatgaag acagcatctt caacgcataa 3005161 agtgaagttg agatggataa ggacgaacta aaaagcagga tcgcaatcag cggaaaatat 3005221 cctgtcaaat aagtattttt catataaaaa agtccctttc tataatctac ctcatttatt 3005281 atggaggact taaaacacat tgacaagata aattattcca ttttttctcc tttttacgaa 3005341 ttacgggccc aaatcttcac aaagcagcat tttgagagta aagtagtacg caggaatcat 3005401 aaaacgtaag gaagttttat atgaaaaaaa cattaaaact gcaaaccaga ctcaccatat 3005461 ttgtttgtat cgttgtatta atcgcattgc tcattacgtt ttttacagtc ggtgcccaaa 3005521 ccaccaaacg aattagagat caggaaaagg ccactgcgct gcagactgct gaaatggtag 3005581 ctgaagcgcc gatgacagcc gctgctttag aaagcggaaa aaaacaaaag gaactgcaga 3005641 gctacacaaa gcgggttcag aaaattaccg gcacggaatt tgttgtcgtc atggatatga 3005701 acggtatccg caaaactcat cctgacccga gcaaaatcgg aaaaaaattc agaggcggtg 3005761 atgagtccga ggtattaaaa gggcatgtcc atatcagcac agcctctggc acgctcggga 3005821 aatcgcagag agcgttcgtc cctgtctacg cggagaatgg aaaacaggtc ggtgcagtcg 3005881 cggtcggcat caccgtaaat gaaattgatg aagtgatcag ccatagctta cggccgcttt 3005941 actttattat ttgcgtcagc atcttcgtcg gtgtgatcgg agccgttatc gtcgcccgta 3006001 cagtgaaaaa tatcatgtac ggacttgaac cttatgaaat tgcgactctg cttgaagaac 3006061 ggagcgcgat gctggaatcg acgaaggaag gaatactcgc tgtcgatgaa catggcaaaa 3006121 ttaaacttgc caacgcggaa gcaaaacgcc tattcgtcaa aatgggcatc aacacaaatc 3006181 ccattgatca ggatgtagat gacatcttgc cgaaaagccg cttgaaaaag gtcattgaga 3006241 caaaaaaacc tcttcaagac agagacgtcc gcattaacgg gctggagctt gtgtttaatg 3006301 aagttcctat ccagctgaaa ggacaaactg tcggagcgat tgcaacattc cgcgacaaga 3006361 ccgaggtaaa acatttagct gaacagcttt ccggtgttaa aatgtatgca aacgcactga 3006421 gagcgcagtc tcatgaattt atgaacaaac tgcatgtgat attaggtctc gtccagctga 3006481 aagagtatga tgatcttgga gattatatta aagatatagc catacagcaa aaatcagaaa 3006541 caagtgaaat tataaatgat gtcaaaagct ccgtactggc cggttttctg cttggaaagc 3006601 aaagctttat acgtgagcag ggcgcaaatc ttgatattga atgcaacggt gtcatcccga 3006661 acgcggcaga cccttctgtc atccatgaac ttattacaat catcggaaat ctcatcaaca 3006721 atggcttaga tgccgttgcc gatatgccga aaaaacaaat caccatgtcc atgcgcttcc 3006781 ataacagcat acttgatatt gaaattaccg atactggagc aggcatgtct gaagaagacc 3006841 aagccaaagt atttgaacaa ggctattcaa caaagggcaa aaaccgggga ttcggccttt 3006901 atttcacaca gcaaagcatc gaaaatttaa aaggccaaat gatcctcaca agcgaaaaga 3006961 atgaaggaac gacattcagt attcgcatcc cgtacgaacc gaaggaggaa aatcatgatt 3007021 aatgtactaa tagttgaaga tgaccccatg gtgggtgaat taaataaacg atacttaagc 3007081 caaatagatg gctttcagct gaaaggcatc gcttcttcct ttcaaagcgc tctgcatatt 3007141 ttaggggagc accatattga cctcattttg cttgatattt atatgccggg aaaaaacggg 3007201 ctggaactgc tgacggaatt gagagcccaa aatgaagcgg ttgacgtgat tgtcatctca 3007261 gcggccagcg agcttgacgt gatcaagaaa acacttcggt acggagctgt tgattattta 3007321 atcaaaccgt ttgaatttga acgattccaa acggctctgt ctgattacag acgaaaacaa 3007381 aaggtgtatt caacccatcg caacatgagc caaaaagaac tggacgccga gctttttcaa 3007441 aagaaagaag caacagaaaa agtgcagctt cctaaaggcc tgacaaaaag cacgctgaag 3007501 ctgatctggt ccagtatcca gtcatttgaa aatgaatctt ttacgacaga agacttggca 3007561 aagcacacag aaatctctca agtatccata cgaaaatact taaagtttct tgaagatata 3007621 caggttctga atgtagaaat ggcgtacgga acgatcggaa gacctgtgtt tcagtacaac 3007681 gtcaacaaca gtaacattaa cggaataaag caatatctat aagaaaacgc actgcttgct 3007741 ttgagcagtg cgtttttctg tcatatctct tgccaagatg cttgattcta ttgttgataa 3007801 gttatacaag aataacaaag ggctttcaca tttttaagca aataattcta aaaatagata 3007861 atttttaaaa aattatgcga aattctattt atttcttatt agttaaatga taaattatga 3007921 ttggttagtt gatcccgaaa aactaagtca taagtcttac ttcagaaaac gatgtcacgg 3007981 ttttccgccc ggaacgcctt ccgcatcctt ctcttccccg cctttcgaag gaaatactca 3008041 caccacgctt attcagggaa gaatagaact gtctcagcgc attccatttg ttattatcag 3008101 aaaattttat cgattctaag aaattgttca ggacagccca tcacatgact ggccggatca 3008161 gctttgaacc aaatttttct ggggggttat atcttgaata aacgaaaaat cggattggcg 3008221 atgtcacttg tgatcgcagc aggcaccata ttaggagcat gcggaaacag cgaaaaaagc 3008281 agcggctcag gcgaaggcaa aaacaaattc agtgtggcga tggttactga cgtaggcgga 3008341 gtggatgaca aatccttcaa ccaatcagcc tgggaaggca tccaagcctt tgggaaagag 3008401 aatgggctga aaaaaggcaa aaacggttac gactatcttc aatccaaatc tgatgcagac 3008461 tatacaacga acttaaataa attggcgcgt gagaattttg acttaattta cggcgtcggc 3008521 tacttaatgg aggattcaat cagcgaaatt gctgaccagc gtaaaaatac aaactttgcg 3008581 attatagatg ctgttgtcga taaagacaac gtcgcaagta ttacgtttaa agagcaggaa 3008641 ggctcatttc tcgtcggagt ggccgcagcc ctatcaagca aatcaggaaa aatcggcttt 3008701 gtaggcggca tggaatcaga gttgatcaaa aaattcgagg tcggcttccg tgccggcgtg 3008761 caagcagtta accctaaagc cgttgtagaa gtgaaatacg cagggggttt cgataaagcc 3008821 gatgtcggta aagcaaccgc cgaaagcatg tataaatcag gcgtagatgt tatttatcac 3008881 tctgcgggcg ccactggcac aggcgtcttt actgaagcga aaaacctgaa aaaagaagat 3008941 ccaaaacgcg atgtctgggt catcggtgtc gataaagacc aatacgcaga aggccaggta 3009001 gaaggaacag atgataacgt caccctcact tccatggtga aaaaagtaga tacagtcgtt 3009061 gaagatgtaa cgaaaaaagc gagtgacgga aagttcccgg gcggcgaaac acttacctac 3009121 gggcttgatc aagacggagt cggcatttct ccatctaaac aaaatctatc ggatgatgtg 3009181 atcaaagcgg tcgataaatg gaagaaaaaa atcatcgacg gattggaaat cccggcaact 3009241 gagaaagagc tgaaaacctt caaagctgaa taagaatcgc agggataagg aggtcgagcc 3009301 cttatccctt gtttttcttt tattttgaaa taaaggagcg gtcaatcaat ggaatatgtc 3009361 attgaaatgc tcaatatccg caaggcgttt ccaggtatcg tcgccaatga caatatcaat 3009421 cttcaagtca aaaaaggcga aatacacgcg ttgctcggtg aaaacggagc ggggaaatca 3009481 acattgatga atgtcctttt cgggctgtat cagccggagc ggggtgaaat tcgggtgcgc 3009541 ggcgagaagg tgcacatcaa cagcccgaac aaagcgaatg accttggaat tggaatggtg 3009601 caccagcact ttatgcttgt tgacaccttt acagttgctg aaaatattat tctcgggaag 3009661 gagccaaaga agtttggcag aattgaccgg aagcgtgctg gccaagaggt gcaggacatt 3009721 tccgatcgat acggcctgca gatccatcct gaagcaaaag cagctgacat atcagtcggt 3009781 atgcagcagc gcgcagaaat attaaaaacc ctctaccgcg gtgccgacat tctgattttt 3009841 gatgaaccga cggctgtttt gacgcctcat gaaattaagg aactgatgca aattatgaag 3009901 aacctggtca aagaagggaa gtccatcatc ttaatcaccc ataagctgaa agagattatg 3009961 gagatttgtg accgcgttac ggttatccgt aaaggaaaag gcatcaaaac ccttgatgtc 3010021 cgtgatacaa accaagacga actcgccagt ctaatggtcg gccgtgaggt atcgttcaaa 3010081 actgaaaaga gagctgctca gccgggagcg gaagtgcttg cgattgacgg cataactgta 3010141 aaggataccc gcggaataga gacagtcaga gatttgtctc tttctgtcaa agcgggagaa 3010201 atagtcggca tagcaggcgt cgacggaaac gggcaatctg agctgatcga agcggtgaca 3010261 ggactccgca aaacagattc aggaacaatc accttaaacg gaaaacagat ccaaaacctg 3010321 acgccaagaa aaatcactga atccgggatc gggcatattc ctcaggatcg ccataaacac 3010381 ggtctcgtcc ttgattttcc aatcggagag aatatcctgc tgcaaagcta ttacaaaaag 3010441 ccgtattcag cattgggcgt tttacataaa ggcgaaatgt acaaaaaagc acgcagcctg 3010501 atcactgagt acgatgtcag aacgccggat gaatatacac acgctcgggc attgtcaggc 3010561 ggaaaccagc aaaaagcgat tatcgggcgg gaaatagacc gaaatcctga tttattaatt 3010621 gccgcccagc cgactcgcgg ccttgatgtc ggagcgattg aatttgtcca taaaaagctc 3010681 attgagcagc gtgatgccgg gaaagccgtt cttctcctct cgtttgagct tgaagaaatt 3010741 atgaatctca gtgacagaat cgccgttatt tttgaaggac gcattatcgc cagcgttaat 3010801 ccgcaggaaa ccactgaaca ggagcttggt ctcttgatgg caggaagcac gcaaaaggaa 3010861 gcggggaaag caaatggtta aacgactctc tcatttactc gtgccgctca tcgcaatcat 3010921 acttggtctt gcggccggcg cgttgattat gcttgtgagc ggctacagtg tggctagcgg 3010981 atattcggct ttgtggaatg ggatattcgg agaaatctat tatgtcggag aaacaatccg 3011041 gcaaattacg ccttatattt tatccggatt ggctgtcgcc tttgcattcc gaaccggact 3011101 ctttaatatc ggcgtcgagg gacagctgct cgtcggctgg acagcagcgg tttgggtcgg 3011161 tacggcgttt gacggaccgg catatattca cttgccgctc gcattgatta cagcggcagc 3011221 tgcaggagga ttatgggggt ttattcccgg cattttgaaa gcgcgatttt acgttcatga 3011281 agtcattgtc accattatga tgaattatat cgcgctgcac atgaccaatt acatcatttc 3011341 aaacgtcttg acagatcatc aggacaagac ggggaaaatt cacgaatccg cctccctccg 3011401 ctctcctttt cttgaacaga tcaccgatta ctcacggctg catttgggaa tcatcgttgc 3011461 ccttctcgca gcagttatca tgtggtttat catcaacaaa tctacaaaag gatttgagct 3011521 ccgggcggtc gggtttaacc agcacgcttc ccagtatgcc ggcatgagcg tgcggaagaa 3011581 tatcatgacc tccatgctta tctccggcgc ttttgcaggt cttgccggag ccatggaggg 3011641 cctagggaca ttcgaatacg cagcagtgaa aggcgcattt accggcgtag gctttgacgg 3011701 tatcgctgtc gctcttctcg ggggaaacac agccgtaggc gttgtactgg cagcatgcct 3011761 gcttggcggg ctgaaaatcg gcgcattaaa tatgccgatt gaatcaggcg ttccatcaga 3011821 ggtcgttgat attgtgattg ccattattat tctatttgtg gcttcaagct atgcgattcg 3011881 tttcgtcatg ggcaaattga agaaaaaggg ggcgaactaa gtggacattg tgcagatttt 3011941 atctatcatt gtccctgcca cactcgtcta tgcggccccg cttattttaa ctgctctcgg 3012001 cggcgtgttt tccgagagat caggtgtggt gaatatcggc ctagaaggcc tcatgattat 3012061 cggggcgttc accagcgtgt tatttaattt attttttggt caggaattag gtgccgccgc 3012121 accttggctt tcgctccttg ccgccatggc agcaggcgcc ctgttttcac tgattcacgc 3012181 ggcagcggcg atttcgtttc gcgccgacca gacagtcagc ggtgtcgcca ttaacatgct 3012241 ggcgcttggg gcaactttat ttatcgtcaa actgatctac ggcaaagcgc agacagacaa 3012301 aattccagag cctttttata agacgaaaat ccccggtttg ggcgatattc ccgtcttggg 3012361 aaagatcttc ttttcggatg tctattatac gtctattctt gcaatagcac ttgcctttat 3012421 ttcctggttt atcttgttca aaacgccgtt cggccttcgt atccgttctg tcggcgagca 3012481 tccgatggcg gccgatacga tgggaatcaa cgtatataaa atgcgctaca tcggcgtgat 3012541 gatcagcgga ttgttcggcg gtctcggcgg cggcgtatat gcctccacaa ttgcgcttga 3012601 tttcacgcac tctaccatct ccgggcaagg ttttatcgcc ctggcagcgc ttgtattcgg 3012661 aaaatggcat ccgatcggag cactgggggc cgccctgttt ttcggattcg cccaaagctt 3012721 aagcatcatt ggatcgctgc tccctctttt taaagacata ccaaatgtgt atatgctgat 3012781 ggctccttat atcttaacga ttctcgcttt aaccggcttt atcgggcggg cagatgcgcc 3012841 aaaagccaat ggcgtgcctt atattaaagg aaaaagataa acattctccc ctgggaagac 3012901 gattctcagg gatttttttc taatccaaaa gaccccctta atttaattgt ttattagttt 3012961 tttaacttaa aaaaatatga agtgttaacg ctttcttgta gactgtaaca aacaatacat 3013021 gggggtgtat gacatgggag caattccaaa aacggggaca atttcacctg agcaaaaaga 3013081 ctcacaggag aaaaacctgt ttcaaaaaat ttggtcttgg gaaatcggtg tgattccttt 3013141 gccattatac acagtattag ctgttattat tattcttgca gcatattaca atgagctgcc 3013201 ggcaaatatg cttggcgggt ttgccatcat tatgattctt ggtgtgtttc tcggagacat 3013261 aggccaacgc ataccgatat tgaaggatat tggcggccct gctattttat ctttgtttgt 3013321 tccttcattt ttagtctttt acaatgtact gaattcaaca tctttagacg ctgtaaccaa 3013381 cttgatgaaa acgtctaact tcctttattt ctatatcgct tgccttgttg tgggaagtat 3013441 cctcggtatg aacagaattg ttttaataca ggggtttatc agaatgttcg ttccactggt 3013501 tgcaggaacg atcgcggccg ttgcagccgg catccttgtc ggatttattt ttggctatag 3013561 tgcctatgat tcctttttct ttgttgttgt cccgattatt gccgggggaa taggtgaagg 3013621 gattttgccg ctttcaatcg cctattcaca aatactgggc tcatccgccg atgtatttgt 3013681 gtctcagctg gtgccagccg caattatagg aaacgttttt gctatcatat gtgcagcctt 3013741 aatgaaaaag cttggcgaca agcgtccaga tctaaatggg aacggacgtc tcgtaaaatc 3013801 taaaaaagca aatgagattt tcaatcaaaa agaagccgaa gcaaaaattg attttaaact 3013861 aatgggagca ggagttctgc tcgcgtgtac attctttatt tttggcgggt tattggagaa 3013921 attcatcttc atcccgggcg cgatcttaat gattatttca gctgcggctg tcaagtatgc 3013981 aaatattctt ccgaaaaaaa tggaagaagg cgcttaccag ctttataagt ttatttcttc 3014041 aagctttaca tggccgctga tggtcggtct cggcatcctc tttattccgt tggatgacgt 3014101 agcgtctgtg atttctatac cgtttgtcat catctgtatt tcagttgtta tcgcgatgat 3014161 tggttctgga tatttcgtag gcaagctgat gaacatgtat ccggttgaat ccgcaatcgt 3014221 tacctgctgc cacagcggtc tcggcggaac gggtgatgtt gccattttat cggcatcagg 3014281 aagaatgggc cttatgccgt ttgcccaaat ttcaacccgt ctcggcggtg caggcacagt 3014341 tatttgcgcg acagtgctgc ttcgtttttt cacttcataa acagaaagag ttccgtttta 3014401 tgcggaactc tttttttatt tattcacaat ccgaatatac tctcggggac caaacggcag 3014461 atcctttgat tccgtctcac tcattctggc tgacaggtgg tgctccagta aatacagctc 3014521 ccactcatca caagccgcca caccgctgcg cccgtcatat tgattcaaca tgaatgcccc 3014581 tgcaaatact gagcagaata aacctgagca catcacgact tttgttttca catgaccagc 3014641 tcctttcctt cagcttgatc aggattgatt ttaaatatac aaataacctc ttttttgtta 3014701 gacttatttt gaggtcaaaa gaactcataa aaatccatta cagcagttcg aagcgtggca 3014761 gcttgcagaa aagtgcgata taatttggac taggtcgttt gaccgtatat tttatacata 3014821 gcgcattttt caattgagaa cgagaaaagg aggtcttatc tttgcagctc ttacatcttg 3014881 ctattttatc gcctttttta tttgctttta tcattccctt cttggcaaaa tacgcaaaaa 3014941 gagtgcatac gggctggttt gtgttgatcc tgcccgtctt gctgtttata tactttctcc 3015001 caatgatcag gatgacgcaa tctggagaaa cacttcgatc ggtattagag tggattccgt 3015061 cactcggcat taactttacc gtttatatag acggcctcgg gttattattc gctttactga 3015121 tcacaggcat tggctctttg gtcactcttt acagcatttt ttatttatcg aaagaaaaag 3015181 aacagcttgg gcccttttat gtctacttat tgatgttcat gggcgccatg ctcggcgtcg 3015241 ttctagtaga caatgtcatg gttctctaca tgttctggga gcttacaagc ctttcatcct 3015301 ttttgctgat cggctattgg tataagcggg aaaagtcgcg ctatggcgca gccaaatcac 3015361 ttttgattac ggtcagcggc gggctgtgca tgctcggcgg atttattctc ctttatttga 3015421 taacggattc cttcagtatt cgagagatgg ttcaccaggt tcaattaatt gccggccacg 3015481 aattgtttat cccggctatg attctcattt tattaggggc ttttacgaaa tcggcgcaat 3015541 ttccttttta catctggctc cctgacgcga tggaagctcc gacgcctgtc agcgcttatc 3015601 tccattcagc tactatggta aaagccggca tttatgtgat tgcgagattc agtcctattt 3015661 tcgccttttc agctcagtgg ttttggatcg tgtccctcgt cggcctcttt acgatggttt 3015721 ggggttcatt ccatgccgtg aaacaaactg atttaaaatc gattttggcg ttttcaaccg 3015781 tcagccagct cggcatgatc atctccatgc tcggagtcag tgctgcggcc cttcattacg 3015841 gacatacaga atattataca gttgccgcta tggctgccat tttccatttg atcaaccacg 3015901 caacctttaa aggaagcttg tttatggcag tcgggattat cgatcacgaa acaggcacac 3015961 gggatatccg gaagctaggc ggcctgatgg cgattatgcc gattactttt accatttcct 3016021 taatcgggac attttcaatg gccggcctac cgccgtttaa cggatttttg agtaaagaaa 3016081 tgtttttcac aagcatgctt cgcgtgacac attttgacct gttcaacgtg cagacatggg 3016141 gcgttctgtt ccctcttttc gcctggatcg gaagtgtatt tacgtttatc tacagcatga 3016201 aattgctgtt taaaacattc agaggaaatt accagcctga acagcttgaa aaacaggctc 3016261 acgaagcgcc tgtcggtatg ctcgttccac cggtcattct tgtcgctttg gctgtcagtc 3016321 tcttcttttt cccgaatata ttgtcgtaca gcctgataga gcctgcgatg aactcaatct 3016381 atccgacact gcttgacggc catgagaaat tccacgttca catttcacag tggcatgggg 3016441 ttacaacgga attgctcatg actgcgggta ttgttgtgat cggaacaatt ggttatttgt 3016501 cgctgaataa gtggaaagga atctataaac tgtttccttc gaaactcaca ctcaaccggt 3016561 tatacgataa gcttttgact atgatggaga aaggctctta ccgggtcaca aaacaatata 3016621 tgaccgggtt tttaagagat tatttgctgt atatcttcgc tggtttcatc attctgatag 3016681 gcggagcttt tgccattaaa ggcggatttt catttaaaac ggaaggcatg gctaaaatcg 3016741 gtgtatacga aatcattttg acgcttgtca tgatcagcgc cacagtggcg actgtttttg 3016801 ctaggtcaag actgacggcg atcattgcac tcggtgttgt cggttatacg cttgcattgt 3016861 tttttgtcat tttcagagcg ccggacttgg cattgactca gctcgtcatt gaaacgattt 3016921 ctgtggcact gtttctgctt tgcttctacc atttgccgaa actgaggctg aaaacaaaaa 3016981 cgagaacgtt ccggatgacg aattttatca tttctttagg cgtcggtgtt atcgttacac 3017041 tgctcggcat cgcatcctca agccagcgga caaaagacag cattgcgtcc ttctttgtca 3017101 aacacagcca cgatctcggc ggaggggata atgtcgtcaa tgtcattctc gttgatttca 3017161 ggggatttga tacaatgttt gaaattacgg tattaacgat agccgctctc ggcatttaca 3017221 gcatgattaa aacaaaagta aaagaggagg ggaaaagcgg tgaatgaaca aaaaacaaat 3017281 gacttgattc ttcaaaccgc gacaaagctt gtatccttta tcattttgct tttctctttc 3017341 tatttatttt tatcagggca taacgcgccc ggaggaggct ttgtcggcgg actgatcacg 3017401 tcctcttcca tcgttctctt gctcttggca tatgatttaa aaaccgtgcg ttcccttttg 3017461 cctgtcaatt tcatttatgt cgcgggagcc ggccttctgc tcgctgtatt aacaggcgtt 3017521 ggctcctttg tcttcggggc tcctttttta acccacacat tcggatactt tcagctgccg 3017581 atccttggga aaacggagct cgccacagcg acgatatttg atttaggcgt ttatcttgtt 3017641 gtcgtaggca taacgatgac cattattcaa acgattggag aggaagaata atggaaatct 3017701 taatggctgt attagccggt attattttta tggctgctac gtatttgctg ctgtctaaaa 3017761 gcctgcttcg cgtcattatc ggaacagcac tgttaagcca tggcgttcat ttaatgcttt 3017821 tgactatggg aggattaaag aaaggcgccg ctccgatttt gagcgagcat gccaaatcat 3017881 ttgtcgatcc gcttccgcaa gccctgattt tgaccgcaat tgtcatttct tttggcgtta 3017941 cgtcattcat cctcgtcatg gcctttcgcg cttatcagga attgaaatcg gacgatatgg 3018001 atcaaatgag gggaaatgat caacatgaat aattttgtta ttttgccaat cctgatcccg 3018061 cttttgtcgg ctattcttct gattttcatg acgaagaatc ttatgctcat gagaatcttc 3018121 agcacggcgg catcggccat cgggattgtg attagcggca tacttgtaca gactgtcttc 3018181 acaaaaggca tccagacact cagcctaggc ggatggaaag cgccgtacgg cattgtgctt 3018241 gccgcagacc aattcgccag ccttctcgtt ctcacaacag cgatcatcgg tttattggtt 3018301 gggctttatt ccttccgttc tgtcggtgaa aaacgggagc gctcctttta ctactccggc 3018361 gttcagttct tgcttgccgg cgtcagcgga gcgtttttaa caggcgattt atttaatatg 3018421 tacgtatttt ttgagcttct gcttattgct tcctatatgc tgattgtatt aggcggcaca 3018481 aaaattcagc tgcgggaatc ccttaaatat attgtgttta atattgtatc gtctgccctg 3018541 tttgtcatag gggtcggctt tttatacgct gtaaccggta cgttaaacat ggcggatctt 3018601 agcgtgaaaa tcagcgaatc aggacaaacc gggctgatca ctgtgattgg tgtcctgctg 3018661 cttttggtat ttggcatgaa gggcggaatc ttccccctct acttttggct tccaggctct 3018721 tattacgcgc caccggcggc aatctccgcg ttgttcggcg ctttgctgac aaaagtcggg 3018781 ttatatgcga ttacgagggt tttcacattg atttttattc acgatacagc ctttacccat 3018841 cagttgatga tttggctggc ggcgctgact gtgatttttg gtgtgatcgg ttcactcgct 3018901 tattcgaatg tcatgaaaat tgtgatctat aacattatta ccgctgtcgg cgtgattttg 3018961 ttcggtgtgg cagtacacac ccccgcatcc attcagggcg cgatctacta tctgattcac 3019021 gatatgctga ttaagggcgc tttgttcatg ctggcaggta cgctgatcgc attgactgga 3019081 accgcgagcc tgcataaaat gggcgggctg atcaaacgct atcctgttct tggatggatg 3019141 tttttcattt ccgctatttc tcttgcaggc attccgccac tgagcggatt tgtcggcaaa 3019201 tttaaaattg cagagggcgg cttcgcagaa ggtgaattta cgatatccat gctgattctg 3019261 ctttcgagtc tgcttgtact gtactctgtg ctgaggatct ttatacatgc gttttggggc 3019321 gaagaaaaag aaacgccaaa accaaatcat cgaacagcta aaggacttct ttatccggca 3019381 gctatttttc tcttgctgtc ccttctcttc ggattgggta cagaatgggt gtcgccttac 3019441 gttgatcaag cggccgagac gctgctgaat ccggaaaaat atatcgaagc tgttctgaag 3019501 gagtagatcg catggcattt caaattttat taaatgtgtt tctcgctttt tgctggatgt 3019561 tcttaagcaa cagtccaagc gccgcaggat tcattacagg ctatattctg ggaatgctct 3019621 ctctcttttt cttccggcgc tttttcactc gccagtttta tctatggaaa ttgatttcta 3019681 ttatcaagct ctgtttcatt tttataaagg aactgtacct tgccaatgtc agtgtgatga 3019741 aatcagtctt atctccaaaa ctgaatatca gaccgggtat ttttgctttt aaaactgaac 3019801 tgacgaagga ctgggaaatc accatgcttt ctctgctcat tacattaacg ccgggaacct 3019861 tggtgatgga tatttcagat gacagaacaa tactttatat tcatgcaatg gatatcgagg 3019921 atgcggaaaa agcgattttt gacattcggg agtcatttga aaaagccata caggaggtga 3019981 gccggtgatg tttacgctga tcctgcaaat cgcgctcggc attatggcag tgtctacctt 3020041 tttgtatgtc attcgtgtca ttaaaggtcc gactgtgcct gaccgggtcg tggctctgga 3020101 tgcaatcggc atcaatctga tcgcaatcac ggcgcttgtc tccattttgc tgaaaacaag 3020161 tgcgtttttg gatattattt tgttgctggg gattttatcg tttatcggaa cgatcgcatt 3020221 ttccaagttc ctggagaaag gagagattat cgaaaatgat cgaaaccgct aaggtcgttg 3020281 tggctgtatt cattttgctg ggtgctctta tatgcctcat tgcttcattt ggcgtacttc 3020341 gccttcccga tgtgtttaca cgcgctcatg ctgcttctaa aggctcaaca ttaggtgtca 3020401 atatgattct gctcggtgtc ttcttctatt tgtggtttgt gacgggggag ctctccgcta 3020461 aaatcctgct tgggattctc tttatcttta ttacgtcgcc tatcggcggg cacttgatct 3020521 gccgtgctgc gtataactcc ggcgtcaagc ttgatgagag aagtgtgcaa gatgactata 3020581 acggaatcag aaactttgtg attaaacgaa aagaggattc ttatttataa aaataagcag 3020641 ccggacaggc agagttccgg ctgttttttt atttcttgat gacagccagc gtgcatctgg 3020701 atatacagat cagcctctct tgctcgtcat atatgtgaat atgatagaca atcgtcgttc 3020761 tgcctatatg aacgggctcg gctatcgcct ttaccgttcc ttcctttaca gattttaaat 3020821 ggttggcgtt aatctccaaa ccaacacaag cttgcgttgt atgatcaatc aggttctgtg 3020881 cacctgcgct cgccgcggtt tccgccaggg ccactgaagc gcctccatgc aaatatccga 3020941 acggctgtac cgtccgatga tccaccggca tgaccgcaac gcatcgttcc gctgtgtttt 3021001 caacaatctc aataccaagc gcttcaagca atgtgtgctt catatccatc tctacacccc 3021061 ccaacattta aagtacaccg tctgatttcg caatcaaaac cgcttccgtc cgtgaaccga 3021121 cattcagctt attgaaaatc gatgtcaagc tgtattcaat ggaccgcttg cttaaatgaa 3021181 gggcatctgc gatttcttgg tttgtaaatc ccttttcaac ttcttgaaga atcaggcatt 3021241 ctctaggtgt gagcacatct tgttcttttt gagaggaagg agccggcttt gttttttgct 3021301 gagtcatcag ctgtttaaag taagcaaaat cgactaaaat ttctccgttg agtacgtggt 3021361 atatgtattg ggtgatcttt tctttagatt ccgttttgct gatggcaccg tgcagacccg 3021421 cacgaatcgc ttcctcgaaa taatcctcga cctcataacc ggtatacacg ataattttac 3021481 aatgaggatt ctcttgtaaa atctgtttag aaagctccat cccattgacc tcgccgccta 3021541 gattcagatc cattaaaatg agatcatatg acgagaaatc atgctgcttg ataaactgtt 3021601 cgctcggttc aggactgaga caatcaacag acaaattcga atccgtttcc aaaattgtct 3021661 tggtgccttc catgacagcc ggatggtcat caatcactag tatctttttc atgttttcct 3021721 cccttttact cactcttttc cattttataa aaaagacttg gcctgtgcca agtcgtttcc 3021781 gttataaatc cattacaatt cgatttcaat atcagcctta aagccctttc cttcacttgt 3021841 ttcaatccga aggcgcccat ctaaagccct gactctctcc ttaatgccag aaagccccat 3021901 gctcatggaa tgctcagtat ttttttcttg atcaaaccca acgccatcgt cctcataatg 3021961 aagaacgatt ttgttttgaa tactgatgag cataatcagc acatccgtcg cctgagagtg 3022021 cttgaccgca ttagacagaa actcttgaat gatccggtac aaattcagct gcgaatccag 3022081 atcaagggaa gccgtaaatc tcccggtatt taaacggata tgaaacggaa cccgctcctg 3022141 ctgctgcgcc accagcttcg acagcgcctt caccaatcca agatcataca gaagctgcgg 3022201 ccgcagctca tgacacgtct ccctcgtcat cgaaatcaca tcagacatct gctcattcat 3022261 ctgtacaagc ttgtcctgca cctcttcacg gcacggatta tcatccttct tgaaatcacc 3022321 caaaaacagc tcacactggc gttttaagga aatcaaatcc tgaagaaccg aatcgtggag 3022381 atcgcgggcg agtcctgaac gctgtttttc ttcgattgca aacattagct ttttcagcca 3022441 gatggggttg gttccctctt gttttaagtc cttcaaatgt tccatgagct cctcaatatg 3022501 caggacattt tccatggaca cacttgtata aaaagacagt gttttcagcc acgatatttc 3022561 atcacgtgtt agccggggag tgttaatatt agataaacaa agcagaacat aagaactacc 3022621 gcctcgttca ccaactttca taagaaagcc ttgattgact tctataattt tcccaatttc 3022681 tgaagttacg ttttcaaatt cctcttgata aaaattccag tccggtccaa cttcatgctt 3022741 atctaaaaat atcactttgt gatcaggagt aacctcaaag gtataagctt tgcttacaag 3022801 caaaacatcc agtatagtat ttttcagttc tttaaaaact tgttgaagag aagttacacc 3022861 cctcattagc tgagtatatt taaaaatact gtcctgatag ttgaattttt cggagaaacg 3022921 ttttaaccga aatttaaaat ccatgacctc tttaaaataa aagacagcga acatgacaac 3022981 gaaaaaaaat acagtttgac gcacagggtt catctggatg tccattacat caaacagaac 3023041 taatgcacca actattagaa gagttggtat catggcaagt agagcatagt atctcattct 3023101 tcctaagata aactctatat caaacatctt attggctaca aattggtata ctaacccgaa 3023161 cggaattagt actagtaatg acgccgaagc taatgccggg aaaatataat tacctgtaaa 3023221 tattattgga agaacaaaaa atatcaaaaa aggcgcaaat gaaagagtgt ttgttaaaat 3023281 tagtaattta agaataaacg aatgctcagc atatttatat ttattaagat gtaagtatat 3023341 cgctgaaaaa gaaaatagag tcaaagttgc aaaagaaacc aaattaagag ttgctaaaaa 3023401 atcaatatct acttgtaaat agtcttgaaa aaactcaata ccaagattaa atattggtat 3023461 gatataaaga aaagaaattc tattcaaaaa agttttacct atttctccaa ggtatctttg 3023521 tataaattga agataaagaa taggagaaga tataaaagta aacaagttaa tataccgatt 3023581 gattatatgt cctctaaatg gtccgcctgc acttatatat gctatcgaaa tgtctaataa 3023641 caatagaata agaatatagg cagcaaatga tctccttttt ttatttactt taagtatata 3023701 aaaaatacat attatgctta aaaaataaaa aaacaaagga agtacgaaca gaaaaaaact 3023761 ataaggtcta tttagagtaa ctaaatcaaa atctttgaga tgaatctttt ttccacttct 3023821 caaaatatcc agactgttaa tatgactcaa atatccccat ttcaaatgtt tgtctgaagg 3023881 tttttcttta ttaattttta atatgatgtc tccctgtctc agaccaacaa attgtccata 3023941 tgaagattcc gatatttctt ctatcataaa ttgactttta tcatttttat gaatcttagt 3024001 cccaataata attccattca tactgatata agttgtatag cttatataaa ggatactcaa 3024061 aacaattaca gctattgtga atttttttat taagttcttc aatattaatc cacctattaa 3024121 tcaccccatt gacgggttat tggatcagcc agataataat cattataagc tttaattatt 3024181 gtttcagttt cttgcacatc aaaacctata aggcaggctt ctttattttt caattttttt 3024241 aaagcctcag gataatttaa aaagtagtta attaggtctt gcatcttgta tccccctttg 3024301 tataacttaa taagcattcc tttattagct cttttttttc tttatctaaa tttaattgtt 3024361 ctatagcaga aatacatttc tgtttatata tttccaataa taccgaaatg tattgagtaa 3024421 ctcccgcttt aattaatttt tcttggaatt tctctttatc aagtaacgat ttataatata 3024481 agtctttatg tgaaattaag tataataaat cttccgaagc atcattaaaa aggcgcttaa 3024541 gatataagta aatcagtgta tgtttgtttt tttcaatatc actgcgattt ccggataaaa 3024601 gaacataata atctccagaa atttgagcta taatcccttt atagtaggaa tatctttcaa 3024661 ctgtttcatt atattctcct gtagccaata aaacacctgc tacatttgct agtgcaatca 3024721 gacttccaca ttttaatcta attacttcta aactttcatc ttctgtttta gatttattag 3024781 tgatatcgtc atgttgacct tgcatggcct cgtttacgta ttttaaaaca tatttaaaaa 3024841 ttagaggatt gttatttaat gaataaatac tcgttaatcc tactgtatac aaggaaagtg 3024901 ctgcatttaa cgactccgag cgattaattt tcatccataa tgcatggtga ttatcttcat 3024961 cttcaagatc atccataata tctgatgaaa gaataagaat ttctattccc gcgccaagcc 3025021 ttgttgcaac atctaaattc tcccctccaa aaacaacata atgtaagatt gtggattcag 3025081 caaaggagaa tgtttcttta gaatcaataa atgagtaaag aagttgtgac aaatcctcgt 3025141 taaatatgtt ttgctccaca atctccttca ttttctcctt gatccggaca gaatctaaac 3025201 atatctgctc aataacgact tcccccctcc cattccattt tactaaatgg gacatttaaa 3025261 ggacagcagg tttttcgttt tttaacaatc atataatact ttatccattt attgtatcgg 3025321 tagaacgaaa aaaaagactt gtttccaagt ctttttcacg aaattttcat tgcataattg 3025381 tatttatcga gttgatcaat gcttttgtta atgtttcgta atgaatctgt cgtttcttta 3025441 atatcaagtt cgagtcggaa taacaattgt tttacttctt caagtttctt ttccatcgtt 3025501 tccacactcc tttttttgaa agatcaatga attgtgtatg gtgaacgagt cctaggtatt 3025561 tgatctgtta ctaatagtgt gtctgctttc ggctcatttt tcaccgaaaa gtatgcaaaa 3025621 aagtcctgcg tgacaccgca aatctcaata ggtccttata ctcaaaggaa tcacaacaag 3025681 aacgggacta tctttctatg cgaaagagcg tttatatgtg ctgaaattga gaaagattct 3025741 taatctcctt gattttaacg ggtttcgcat tttcactaag caagactata gtccttcata 3025801 ccgtattttc aaaattgaat atgcgattct tggcgtttcc tgaccgacaa acaccgaaaa 3025861 agaccgcaac gctaaagttg tggccttttc gctttgtcat attcggcaat tagggatcta 3025921 tacatataga aacatccttt tttgcgaggt gctcccatga gatatcgtta tccctggttt 3025981 tacgtgtatc cgtatgaggt acgccgtccg cccgctcctg ccaacaatat tgataccttt 3026041 atccgttcag cgaagcaggc cgcagggata tttgcggatg cccagctcgt tctcagccgc 3026101 attgcgggct cgcgggagct ttcgcgccgc attctgaccg cagccgaaca gtctgataaa 3026161 caaactataa ggcgcctgat caaacaaatg ggcgtccggc atgaagtgga tacggtcttt 3026221 aatcccgacg gcatctatat cagccttatc ggaacgcaaa gccgaatgat tcttgctttg 3026281 cggtggtcag aggaccgcaa tcattttgcg tccataagat tatgacacca ttccagagcc 3026341 tctaaataac attcatacgc ttcttctttg tccagttgat tgcctaattc tgagcaagtg 3026401 tcccagttgt tgctttcaat taatttcaca agctcaagca tttggtagta gtcgttttga 3026461 tggcctaata atgcttgccc gacttcatct tttaaaggca attcttgaac aatttcctct 3026521 atttctctat gcaggagggt gtctatgaga gaaaacattc cgatcagcat ataagaagca 3026581 ggctgcggcc gggatgtctt tctcgccagc agttcgcaaa gctttgctct tatcagagaa 3026641 atcttaatga tttcgtgctt gctggaatgc cctttcctgc ttaaatcctt aaaggaaaga 3026701 atatatatcc accgtttgat ttcattaaat cccagcagca taatggcctg ttgaatgctt 3026761 tcaattttct ggctcaaacg gctgtgggat gagtttaaaa attttaaaat ttgataggac 3026821 agtgataaat cccgctctat gtactctgtc acacgcttta tgttaggctg ctctttactc 3026881 agttcgttaa gcagttcata gtaagaatag aaatgagtcg ataggtcatg cccgctgatg 3026941 atgcgcggct cgctgaaaaa gtagccttgg aataattgaa agccgtcttg gaccgcctgt 3027001 ttatattctt ttcgggtctc tactttttcc gctaaaaaaa tcaggccgcg gcagccgtag 3027061 gtttgcaaaa ttgttctgcg ttccattcgt gttgttttga gaaaatcaat tttcaatata 3027121 tcaatatagc tcatgagttt ttccagtaag tcctcatctt gcggatttat tgcataaaaa 3027181 tcatcaagcg ccagcatata ccccattttt ttcaattctt tgcatctaga aatgagggcc 3027241 ggcgtgatcg gtatatcttc aaggatttca atgacaagct gtttcggatt gaaggaggtg 3027301 ggaagattcg aaaacatcag gctttccgta aaattaacaa aacagcgttt cccttccgtc 3027361 agcttctcaa ttccgatgtt taaaaagctg ttgatcacca aatctgttgt tgcctgatcg 3027421 ccgtctttag cgctatacac gttctcttcg ctttctctat acagcagttc ataagcaaca 3027481 acctgttctt ttctattaaa aataggctgt cttgcaacaa acaccctcat tgatttatcc 3027541 cccttacaat acgcgcggct ttcaccccta agtatatcaa ataatttgac gaaaattgtc 3027601 taaacatgaa aaataatata tacataaaga aaactggccc ttcgcgaatg aaaggccagt 3027661 ttttctttat tcttcctcaa gctcttcttc aattctgctt ttcacttcgt ggatccgctg 3027721 cattttattg ctccagcagt cctcgcttaa atcaaccggg tattcctccg gcttgctgat 3027781 tctcttatat tcctcccaaa gcaggctgag gttatcctgc acatactgct gtatgtctga 3027841 aatctcaggg ttttggtagc aaagaatacc cttctcaaaa atcagttcat gaagatcctt 3027901 cgcataaaaa ttcgtgacaa atttgctgat gaatgtatga accgggtgga acattctgag 3027961 ccgcttctga tcattcacct gctcatcata aagcgcaata tagtcgcctt cagaatgatg 3028021 gttggactga ttaataatgc ggtagacttt ctttctgccc ggtgtcgtca ctttttcagg 3028081 attggacgaa attttgatcg tgtcgaccat tttcccgtct tcttcaatgg caacgagttt 3028141 ataaactgcg ccgagagccg gctggtcata ggcagtgatc agcttcgtac cgacacccca 3028201 gacatcaatg cgcgctccct gagcctttaa attcataatg gtgtgctcat ccaaatcgct 3028261 tgaagcaatc accttcgcat ctgtaaatcc tgcttcatca agcattttcc gggctttttt 3028321 tgacaggtac gccaaatcgc cgctgtccag acggatgcca atgaaattaa tgcggtcgcc 3028381 gaattccttg gcaaccctaa tcgcgttcgg catgcctgaa cgaagcgtgt catacgtgtc 3028441 aactaagaag acgcaatcct tatgtgtttc cgcgtatttt ttgaaagctg tatattcatc 3028501 gcggtaagcc tgcacaagcg catgcgcatg tgtgccggaa accgggatat taaagcgctt 3028561 tccggctctt acattgcttg tcgcgctaaa gccgccgatt aaggctgctc tcgctcccca 3028621 catggccgca tccatttcgt gcgcccgtct tgttccgaat tcaagcgcaa cttcatcacc 3028681 gatgacgcct ttaatccggg cagcctttgt tgcgattaat gtttgatagt tcacaatgtt 3028741 gagcaaagct gtttcaatca gctgcgcttc taccaggggt gcctccaccc tcataatcgg 3028801 ctcattgtta aaaacgagtt ctccttcttt catggagtaa agtgaacctg taaaagataa 3028861 gccgcgcaaa tattcaataa aatcttcatg atacccgagt tcatcctgta aataactcaa 3028921 atcgctatcc gtaaacttga aattttccaa gtattcaatg gctttttcca agcccgcaaa 3028981 tacggcatag ccattttcaa acggaagcct tctgaaaaac agctcaaaaa tcgctttctt 3029041 ttcatgaatg ccgtctctcc agtacgtttc cgccatattg atctgataaa ggtctgtatg 3029101 taatgacagg ctgtcatctt taaatccgta ctctaacact gtttttcccc ttccttactc 3029161 tgccacttgc gctccgatgc tgtttgcaaa atgggaaaga gcccatgcgt gcccctcctg 3029221 attaaagctg gcaacagctt gtttatgcac aacaatccga aaacctttgt tgtatgcgtc 3029281 aacagctgta tgcaacacac aaatatctgt gcagacaccg gcaagatgca gttcgccaat 3029341 ctgccgctct ctgagtttga gctctaaatc agttcccgca aaagcagaat atctcgtttt 3029401 ttccatgtag taaacattag gttcatgttc atgtttctga tatagaggca aaagctttcc 3029461 gtacagatct tttccttccg tgccttttat attatgcgga ggaaaaagac gggtttcagg 3029521 gtgatattga tccccttcat catgagaatc tactgctaat acgacgtaat caccgtttgt 3029581 gatgaattct ttagttaaat tgacgatcgc ctcttcaatc attctgccgg gctccccgca 3029641 ggtcaatttt ccgtcactcg ccacaaaatc attcgtataa tcaatacaaa taagtgcttt 3029701 tttcatagcc ggcctccccg ccatcagtat gagaacatta tatcttatct ccagttgtaa 3029761 gtgaattgcc atgaacaaaa agacaaacgg tccgtttgtc tcttacgatt tcagtactga 3029821 ccgattataa atgtcgtcct gaatatatat caattcacga ttcacagcga tatcagccgc 3029881 aatgacgatg cctaagggcg tatgaaactg gagatcagat acaatcttga aaggcactcc 3029941 gtaccggctc gccatttgga tataagaaga gtaagactga tactgaagct ctccattaat 3030001 caaaagggtg acgttatggc tgtttttcag ctcgtgctct gcctctttat acggtttgct 3030061 tctaagcacc tgtcctttcg tcagtgccaa aacgactctt tctcttaaag agcctaaaaa 3030121 caaatggcgc tcgtcaggct ttgtctccaa aggcccatac attccttgct gcaaatagag 3030181 atccatttta tcttcactca aaagcctgtc ctcccgtctt gtttgtcttc attatcacct 3030241 gatcaggcag gagctaaact ttcaagcgcc gtttacattt ctgttaccca atgaatgatt 3030301 tttttggcca gctcaccagc aggggtttcc tctgtatgcc ggcgcaacga cgcttccagc 3030361 cgttcaggca gagttgcttt atcttcttca taggaaatga tcgtgctcca ctccagctgc 3030421 ggtaccgcta caagcgtgcg cagttctttt ctgttttcat gcagatacac gtccgtgatc 3030481 attccggttt gcgtattgat atttgctttt ctgattttca taacatgacc tctctattca 3030541 aagactaccc atattataca ataaaaaagc aacagcctct tgtgaaaagg ctgttacccg 3030601 ttaaacgaaa ctgtttcatc agtgatatcg gcatctttga agagagtttt actcgtttgg 3030661 ttgttaatct tcacaaaatc accaagctga aatgtgcctg accccgcccc tgaatgagcg 3030721 acgcttttgg gcgaaatcgc aaatacgtct ccaaagcttg ccgcggcatt atccgtaact 3030781 gacatgatat aaatcggccc cacaattgca ggcatttccc cacctccgca ttgatttaca 3030841 gcatcatatg caaggagccg ataatggtgc ccgcctattc agctggcttt gcgttttcct 3030901 cgagtcgtga ccgctggcgc agcttgatca agcggacaat attcaggaag aacgccttca 3030961 ctaccgcata aaccggcacc gctaaaatca tgccgagaat tccgccgaag cttcccgctc 3031021 cgattaatag caaaataatc gtaagcggat gggtattcag ccgctttccg atcacaagag 3031081 gagacagcag gtttccgtcc agctgctgaa cgatgacgac cacaataatc gcaaacagcg 3031141 ctttggccgg cgagtccata aaaccgacaa tgacagccgg cgcggcaccg agaaaaggcc 3031201 cgacataggg aatgatattg gtaatcgcca tgacaatccc aagaatcagg gcatacggca 3031261 gtccggcaat taaatagccg ataaaacacg ctgttccgac aaaaagacag attaacagct 3031321 gcccctggaa atatgccgca agcgtatcgg ataaatcttt aaaaatcttt aagccttctg 3031381 tccgataaga agccggtaga atttttactg ccaaatgcgg aaagcggtgt ccgtctttca 3031441 gcatgtaaaa aaggataaat ggaacagtaa taataacaag cgtgatgttt gtcacgacac 3031501 caaacaccgc agataaactg gacgtgatat tttgcggcag gttttggaga aaacttgtca 3031561 atgactgttc aatttttgat atcgatacat aatcctggtt catcatccag gtaaaccatt 3031621 gagaatggga caaatccttt gtcagcgcct gaatctgttt tatataatca ggaaggttgt 3031681 taaacagccc tgtcacctgt gcggtgatga taggtccgac tgacgctgaa ataaaggcaa 3031741 gcaaaccgat aaacagtaaa tagatcaata gaatggataa tgtccgcgga atttttttct 3031801 caagcaggcg gacgaccgga ttaaatatga aatacaaaat tcccgcaatt agcatcggga 3031861 aaaacaatgt cgagataaaa acaataaacg gctgaaatac aaatgaaact tttgttgcta 3031921 caaaaataat cagcaaaaca aataaaatct gcaatgtcca aaaatggact tttgatttca 3031981 acaagctttg ttcctcctag tttttctttg tctgtcagat aaaagaactt ataccccatc 3032041 attgtaacaa aaatgaactc atatcagaac tcttaatata atgaaaggag tgttggtgat 3032101 gaaggccgtg acatacgata cagattcaga actggcttat atctatgttc ttcctccgaa 3032161 aaagaacagg aatgtacgga ctgaggagct cagagtcaat gattgtctcc tgctggatat 3032221 cagccaagat ggcaaaatcg ccggattcga atgttttggt gaggcagcac acctctgtgc 3032281 cccatttgcc gggaaatccc ggctgtatgt aaaagattca gacggttatc attttcgggt 3032341 ctgccagcat gcttcagtcc gttcctgcta tacggtgtac cgtgtcactt tctgtttttc 3032401 agatggtgac tatcaggaat ttgccggctt tgaccttgat ggaacaatgt atcatagtgc 3032461 gtttttacag cgcttaactg aaaaatagga cgtcctgttg tacgcctatt tttcatgcgc 3032521 aagcactgtt agacccgctc actgtaatct ggggtgacgg aaatcatgtg ctggattctg 3032581 atcaaacaaa cagaatttcg ggctccttca attgtgatat ggtcaggttt tacatcgatc 3032641 agtctgcctc tgaccgtatc tcgtactgtc tgtataacga accttgagcc gatgagcttt 3032701 ttaatggtct gatagacata aggatcgact aaagagacca gttgcggact accttggttg 3032761 accatacttt tatccccttt gtgtgtttta tctcagctta tgccgcgctt atggataatg 3032821 acacaggctt acctgataaa acaaaggggt gcggagattt taggagaata cgtttggagg 3032881 cgggtgtaaa ggaagtatcg atgaagcgga gacagcgaag aaagctggcg ctgttccgta 3032941 cttatacagg ctttatcacg gatgcctggg cttggtcgat taattggtcc agcttttcta 3033001 ttttttttcg tgcggttgaa ggatcaattt ggcggtaatg atggtggccg cccggctctt 3033061 catccagttc gtccgctttt ttgacaatct gctgcagtgt gtttttatct aattcgcctt 3033121 caggcaaata ggaatctgta tgaagcaaaa tggctagtgc aatctctttt gctgctttcg 3033181 gttcctcgcc aagccgaatc agaagtttat gcgcccgttc cgccccttta atggcatgaa 3033241 tgtcatttct tttgtatttc tcataatccc actttccgtc tgtataccat tcataatggc 3033301 caatgtcatg aagcagtgcc gcttttgctg ctaaatcagg attaatgtca gccttcacag 3033361 acagcctgta tgcatgataa gcgcaggcaa tcgcatgtgc cacgccggaa cgctgaagat 3033421 atttttgtgc aattggatgg gtgaaaacat ccattaatgt aacctttctc atggaaaccc 3033481 ctcctttaga tatttttaga atcctaacat aatttgcaga gaaactcaat tcttatgtca 3033541 catcattttg atcttcttat catcattgtt ataccctaaa agcaacgttt cagtcagtat 3033601 atgcggctgt tcaataaaat gcgctggctg cagccttttg tataaaaaaa agagcagaaa 3033661 atatctgctc tacaaaaact ctttaatatc ataaatgcgg ccgttttccg tccctttttc 3033721 tagtaaagaa agcagcgtgc cggcaataaa gtccggactg cgaaggcttc ctgtttcatt 3033781 taatttccgg aatcgttcaa tgtggtggaa atcctttttc gatgaagaac ggatgacggc 3033841 ctgcatctca gtgtccatca ctccaggtga gaacgaaatc atgttcaccg gcagctcttc 3033901 atcctcctgt tcaaatccga atgtcctcgt aaacatgtcg agcccggctt ttgaactgca 3033961 atacgcgctc catcccttat atggattttt ggcggctcct gaagtaatgt tgacaaccgt 3034021 ctttttgccg ctgtatgaag caaaccgttt tgtaaacagc tgactcaaaa gcacgggcgc 3034081 agtcaggttc agctgataat ggcgctgaag ctcgtcaaga gacgcttcgc cggcacgttt 3034141 gatcggcgtt accattccgg cgttattaat aagggtaata ccagaataac gatctgaatc 3034201 gatggatgag agcaatgttt caaattgctg ttcagcttct tcgagattga tgaggtctat 3034261 ttgatgctgc gttagttttt tgtgagagac atctgttttc gttctggata aggcatggac 3034321 ttcatgcccc ttttctaaag cctgtaatgc aatggcttga cccagccctt ttgacgctcc 3034381 ggtgatgata taaagttcca ttggaaacct ccttttccgt tattattgta cggcacctct 3034441 tttacacaac acaagcacgc ggcctacgcc ttcttgtttt cctgcgctgt gacttttggg 3034501 atgaggaaca cgatgcctgc aattccgagc aggatcagta cgacatagat catcggcagc 3034561 agcaatgatg atgtttcttg ttcatcttct gtttccgttg atgatgtctt tgtcattggt 3034621 ttttcagcaa aagtaattcc aagctgtttc gactgggccg caatcgtgtt ggaatcctcg 3034681 gcatttgttg atgtaaacaa atcttttatc agctcggcgt ccttgtcctt cggtttatca 3034741 aaagtgatat ccttttgttc ctcaggcagt tctgtttttt cttcatagta ggtatcttca 3034801 tgcaaataat tcgtatcgat ttcgatgtct tttttctcat actggtttgg cgcgacatct 3034861 gtattttctt cagtttgggc agccgctgca gagggtatga aaagggaaaa ggagagcata 3034921 caaatcatga tccccttttc catgctgcga tcacgcttca tacgtttcat cgctttctgc 3034981 tgtgtgttca gccatcaacc ggataatcag cggcagagcc acggcaatca ccgtaatgat 3035041 cagcagaact gttattccca ttgtaaacaa gtgcccagta ccgtactgga tgtcgatata 3035101 tactttcgaa accggatctt caaatgtaaa gttcggcatg atcaaatcaa taagcggtgc 3035161 gacatagaat aggatcattg ctgctgaagc aacccagcca gggattgatc cgaatctgaa 3035221 tgccgtccgg atgaaggcag agcttgcgac cagcaataga atcgtaaaca ccgaccactt 3035281 aatcgtctga tcgtccggca gtgaataaat attcaagccg aacaagctga tcataagtcc 3035341 gacaaggata ttcagaattc cgaataacgc tcctttgacg agaagcggtg cgttttggta 3035401 atacgagctg aaatagccga ttaacagact gctgatcaac acaatgacaa ggatgacaac 3035461 cggaggtacc gtctgaattt tttcttccgg aacctctccg ctgattttaa gcggattcgc 3035521 taagtaatca tatacatagc cattgttttg cccgtctact aatgtatttc cgagtatgcc 3035581 gtatacgtca tttcgcacga gtttcgtgga ggcgacattt ttcccccagt tgttgtttaa 3035641 ggtgtcggct ttcgcttgaa catcattaac gctttgctgc atgttggttg tgtaatcaat 3035701 gatgccggac tggcgatcag acaatgaacc catcatgtct gacatttgca gcacttcctg 3035761 gccgaccgta tcttggacac tcagtgccat ggtaccagac agcccatcgt tgctgaacgt 3035821 cgcagattcc tgtgttgcgc ccgttacaag ctgttctgac gcttttgcgg cactttcaga 3035881 gattttcgtc agttcgtcga gaacacctgc ttgagagtca cggatatagc cgctgtagtc 3035941 gtccgcaaat ttggtcatgc cgtcgatgaa gctgttaata tcctcatctg tttgcatcgt 3036001 gttgtttttg agagcttccc agctggctga ttcttcaggt gtgagagcca ggactgattg 3036061 gacgttgcca tcttgctctt ggatgacttc acctttaata atagtcaaag agcctagatc 3036121 cagattatca tttagcgtag acttatataa atttaaagag ttgtaatact tcatcaagtt 3036181 agaaatatta tcagtttcaa ttctacttga aaaaattgaa cttagttttt ctttctgatc 3036241 tatatagcct ctactctgca aagtttgtat tatttcgtct tccaaattgt atattaacct 3036301 ataagcatca ttgacattat tatcaaaatc aaccaacttt tttgttaagt caccaatttg 3036361 atcatttaat tttgaaactg ttttatttaa ctctttaatt tcttgattta actcatcaat 3036421 atgtttctct agtttgttgt tatgttcctc ttgtttttct tgaagtgcat tttctatttc 3036481 ctctaatttt atcgctgctt cgttcagacg tttttttgca cctgaaatat cagtttcacc 3036541 gtcagctccg tcaccctgta gcccatcact ttgatttgag ccatcgtttt catctgcgag 3036601 ttcaatcaaa gagaaatctg ttttagaggt tcctgtattc tccgtgtttg tatcttgttc 3036661 aggaacgttt tttgaagatt cttgatgttt ttgtcccgtt tcaatgttag tttgaacatc 3036721 attttgtgat ccattatctt gagtaccctc ttctgatgag ccagtatctt catttgttgg 3036781 ctgatcatcg gatgttggaa tatcattcga cggttcttca gtattaggag aatcatcggt 3036841 tgatggttct tcagcatcgg gtgttgttgg tttttcttgt tcaggttctt ttaacccttc 3036901 agagatatct ttaatttcag ttgcaacatt tttgagctca tcccgctgct tctctaaatc 3036961 caattttata tcttcaatat cttccttatc tgtgtcatct ttattatcag atgtgtcttc 3037021 tccatcttcc ttttcgtcgc tttccttagg tttaagtaaa ctaaggcggt tcttcccgat 3037081 attctcttgc aattgattta aattttgata tttaatagct tcatattgac ttttatatcg 3037141 agatagaaat gcattaaaca tgtcattctc aatttttttc atacccattt cttgcaatgg 3037201 cacttgattt tgccttaact tttcagcatt gttcaacgca aggtttgtca gtcctatttg 3037261 tgtcttcgct tggccgatcc cggttgccaa tccgctcatg cgttcgctga actgattcgc 3037321 cttttgctgt gcctggatgg catccagacc tgtccggatt tgctgctgtg ttgaatcctg 3037381 ggctgccaaa agcagctttt tctgattctc ttgatattct ttgtaccttt caactgtatc 3037441 aatgaattct ttcagcgtgt ttttggcttc ctccgccgta gaagcttttt cttttgtcgt 3037501 gccttgcgct tcattcattg atttcttcag ctcatcgatt aagtcttttt gctgtttgat 3037561 ttcacctgct aaatcattag agcttggttt gtaaaagttg tacatgacat tctggaattc 3037621 agattcttta ttgacgatct tgtcaaattc tcctctgatg ttgtccactt tttgcgaaac 3037681 aaaattccag tataaggccg acattttttt gttcattgtc ttttgggcat cctcaagctc 3037741 acgctgaact ttttctttgt taaccgcatt caggttatct tgaatgctga attcgagcgt 3037801 tgccttttga ggatggtctt tgtcatagct caaaatgttt tttgagaagt ctgagggaat 3037861 gtagacaatc gcatcgtatt tctttgaagc gagaccggtc tcggccgcgc ttcggtttac 3037921 gaccgtccac gaataatcag gacgttcacc cagaacggcc gctacttcct tgccgaactg 3037981 ggcggatttg tcctcttcat cagactttac ctcatcactc aatacgcctg tgtcttcatt 3038041 caccaccgcg atttgccggg tagaattgac tgcttttttc gttgggtcgt ctccgataaa 3038101 tcggaaaaac aacaccggca gcagcaaaat gatgatgacg gcggatatta acttgatcaa 3038161 gctttttcgt tgttctgtca tctagcactc tccctttcag cagaacataa aggaatttga 3038221 actttttgct ccttcccgtt ttccacaaca tatccgaagc ccggctgaat ctcaggctcc 3038281 tgtctttggt acgggagagg aatgacattt tgctcagact ttttcatcag cagaatcgcg 3038341 tggcggattt gcttcatctc agtcgtcaag gagtcatagc cttttgagaa ttcgctgtgg 3038401 tttccgcccg ggataaagct gaacccaaga tgagcgtatg atttcatgaa gttagcgaga 3038461 cgatcttgta ttctcgtatc aatcgtctgc tggaatctcg ttatcccgtc aatcatcagc 3038521 acgacttgtg agaatcgcag attttgtgcg tctccttggc ggacggcttc tacatacatg 3038581 gcttctcttg ttttgaaaat gtcttctgct gtttcaatcc actgctcaat atcttctttc 3038641 gtttccaaat atgaaacatc tgattccttc gcataatgag ataagccgcg gtcaatcgag 3038701 tcaaacaggc cgatcatttc ggtttcatca tcaatcagat gttcaagcat gacttttagg 3038761 acgtttgttt tcccgcgctg agtttggcct aaaatcaggc agtgcttatg cttgcccaaa 3038821 tcaaaataga ctgggctgac tgtttcttca tgaagcccga tcggtacaga taaaggcttg 3038881 cgttccagct tgaagcggat agacaattct ctcgtcgaca agctctcagg cagcatcgga 3038941 atcggtgccg gctgctccat tgaagcaaat cgcccttgaa gtttctgtac gtctgatttc 3039001 agctcgttga acatgccgat atcatcatcg gcgtcaacag gcaggaacat ttgcgcgaaa 3039061 taaagctctt ccttttgaat gatgacgcgt cccggaatcg gctcaagatt gaatttcgga 3039121 cggccgtaaa tggaatatcc ttctgattga tccatgagat aatggacaat ctttgttttc 3039181 aagttattta acaatgactg gcggacagca ttcacccgcg ttgctgtcag cataaagtag 3039241 atacccaagc tttgtccgtc tctggaaagc tggacaaatt ccgattcaag ctcatgcatc 3039301 tcatccttga caatgtcaaa gttgtcaatg gtgataaaaa tgaatggaag ctcttcttcg 3039361 ctcagcgcat tgtacatttt gatgtggctg atttcttttt cccggaacaa acgtttacgg 3039421 cggtcaattt cttctttgat gcgaatcatg aacttttcaa ttttccttga ctggtccatc 3039481 aggaagtaat ccgcggtatg cgggagcttc gctaatggca gcagcgttcc gtttccgaaa 3039541 tcaaagatat agacatgaag ctcttcaggt gtgtatacgt ccgcaaaact catcaggaac 3039601 gttgcggctg caatcgattt tccgtagccc gaagagccga agatgccgat atttccatct 3039661 tccatcatct tataagcaat tggcgcctgt ctttgcagat caggttcatc gacatacgca 3039721 aagtggaaat ggtctttttc gtttgaaggg aaaagagtgc gcggaatacg ttccgcaagc 3039781 ggcggcagcc aagggcttgg cagcttctcg attcccattt catcttggat gcgttcaatt 3039841 tcgtcaacta cagcttcgat ttcggtttga acgtcttttt tcgcgttatc ttcggtatca 3039901 acctcagaaa gcgggatcag acccgtatct gtgacgatcg cgatttcatc ctcggtaccg 3039961 tagacttcct ctaagtaagg cgccccgctc catgcagatt ggaacagctc atacacttca 3040021 ttgtttccga cctgcaaata gccgcggcct gttacggtaa tgtttgcggc atcgctgttt 3040081 ttcaaaattt ctttactgtc ggtggcatcc tggaccttga gcgctacttt aaagcgcgag 3040141 ttactccaga tctggtcgtc gatgatgccg cctggcttct gtgtcgccaa aatcaaatga 3040201 acgccgaggc ttcgtccgat acgcgcggca ctgacaagct ccctgataaa atcaggctcc 3040261 tcgcttttca gctcggcaaa ctcatcagaa attaagaaca agtgaggcat cgccacttct 3040321 gctttccctt gcttgtatag ctttgtatag tcattgatgt gattgacttg atactggtca 3040381 aacaggcgct gccttttttt tagctcgctt ttaatggaag caagcgcacg catactgaag 3040441 tttttgcttc cttcaatatt tgtgatcgtg ccgaggaggt ggggaatgtt acggaacggc 3040501 tgcgccattc ctccgccttt atagtcaatt agtaagaaag ccgcttcatg cggatgaaaa 3040561 tgcactgcaa gtgacaagat gtaggtctgg agaaattcac ttttccctga tcccgttgtc 3040621 cccgcaagca agccgtgcgg accgtgtgct ttttcgtgaa ggttcagata cacaatgtca 3040681 tctttccctt tatagccgat cggcactgac agcgacttcg acgattcact tgtcagccat 3040741 ctttgctgaa tgccgatttc ttttacttcc ttcgcatgaa aaagctccag gaacgatacc 3040801 gtttccggaa tggaattcgt aatgccgacc tggtggttca gcgtccgcag tgtgcgtgaa 3040861 aaccgttcgt tatcctcacg ctgatgatga tcgagacgga acggaattct taccgctttt 3040921 ttcttttgta ttaaaatgtc gccttcatgc tcattaatgt agcggacaag agttgtaatg 3040981 ttttccgaca agctttcctt tgtttctgca gcgacaattg tcgagatgcc cagatgctca 3041041 tgctgccctt ctaaatattc gagaatgaca tgctcagaga tcagctgctg attcgtgatg 3041101 acaaatacaa aatgcggttt gaactgcagt ttttctttgt catcttcgag atcacgctct 3041161 ctgatcaatt cgtaaagtga agacaggagc tgatctcggg tttgctcatt ataaataaat 3041221 ccttttgcat aaatatgggg catttgaaat tgcggaagcc acttcatcca ctcccagtct 3041281 ttatactctt cttcatgaaa aataaatacg aaacgcaaat cgtgatagct gttaaagaac 3041341 gacagctgtc cgattagctg gtgaatctca tttttcacaa tttgtgattt accgacaagc 3041401 cccatcggac cttctgccaa atcgaccgtc accggcgcat tacggatatc tttatagacg 3041461 cgttgcatgt gctgcgattt ctccatgagg tcatcgatat cacgattcgc caagtctccg 3041521 ccactcatat tgatttcata gcttgacgga actgttcccg tcccaagccg cagctggaga 3041581 taatccttgc tttcaagtga tttttcccag atccggtcac tgatttcact tgttaagtat 3041641 ttcatttgtt caaatgaagg aaagtgaaat tcaagaacct gcttttgctt ttcagcaagt 3041701 gcctgaagct ctttccgctt attgtctaag taaagcttat atacacgctc ccgtttttcc 3041761 tcgcgttttt tccgctggtt tttatcacgg aaatattgca ctgtcgaggt aatgagagtc 3041821 atcataaaca tcgccaaaga aacgagtata aatatgccgc gcggctggat gatggcaact 3041881 acgcccatca cgatcagcat cacaagcgga ggcaggatga cgagccacag ccctctgttg 3041941 gtttgatcgc tctcctgaga gggaaaactg aaagaaacgc ggtcatccgg cagatcgtat 3042001 accatccgcg gcgttcttct gtactgcgga tattttttct gcatctctgt actcggtttg 3042061 accgtttctg ttaacgctgt ttcaaactgg gcataatgaa caatttctaa aaggtcttgt 3042121 tccgtcaccc tcatttgcgt gaagttccag aatatttcat cccccggctt gagcggcgta 3042181 ttggcgttga ttttctctcc gttcaagaag atcgttccgc tttcagggcg gaccgaccag 3042241 ctgccgcctg cacggagcaa agaaaacgtg ctttgttctg caaatgcaaa atcttgcgga 3042301 ttcagataaa tatctgcatt cgttttttct gaggaacata caatttcatc ccgatttccc 3042361 gtaaaataaa cggatttctc aggttcactg cccgtcaata tcaagcgtat atcctgctga 3042421 tccgtttgga gagtaaatga tatatccgtc tcaatcgtgc cgagacaatc atttcccagg 3042481 aaaacttcgt attggccgcc ggattccttt cttttaagag aaatcactcc gctattaaat 3042541 ggaatggtgc tgatcgtaac agaatccttc acatcaggcc ctatggtcac cggatgagac 3042601 gacgggaggt tagacagatt taatttttga acgttatttt ggtaaaaaac ccataataga 3042661 ctcaaatggc gaaccccctt acggccgaat ggcagcatgc gatgacctgc gcttcatgtc 3042721 tcacgttatt tgtcatcttt tttctcatct ttcttttctg tttctttttt ctcgtcttct 3042781 ttttccttct gttcttcttt tttcgctttt tcctcggctg cggctttttc ttctgccgct 3042841 ttctcttctg cttgtttttc ttcgtctgtt tgtgtctgtt cttcgcttgt atcgactaac 3042901 gatgtttcag aattagactg tttattttct tgacgttctt tttgggcttt ttcaagctca 3042961 ctatttactg aatcaagttc tttttgtatg tcttcatcat ttgtatcctc agataaaagc 3043021 tgctgtttat atttagctag ggcaaagtaa atataatcat tgtattccag cttacggccg 3043081 atactgatcg cttctttgta ttctcctcga ccataatcaa tccaatataa gaaatgctga 3043141 gggtctgatt gaagggtgac taaattattt tctatatttt tggtttttgc actccccagg 3043201 ttttcgacct caacatagga cgtcgccagc tgatactgca ccgattcagg caggctttcc 3043261 gcatcgtact tggacagtgt gctgatgact tcactgtact gcttgtttaa gaacgcacgg 3043321 ttgctgtcca ctatcgcctg gtgctttggc tgcgcgaaaa ataaggcgta catcgaataa 3043381 ataagtgccg gtacaagcaa aacaatgagc cccaggccga tatatcgctg gatgttccac 3043441 ttctttctcg ggatatgtat gtatgttttt gctttggctt cgagctcatc aatatgggtt 3043501 tgaatcagct cgagcaaatc atcataggat tcagcatcta atatcgcctt tgcctctgcg 3043561 gagaacgtca gcgtttcatt gaatttcagg tagtcttcaa acgcaaaagc gccgtcaact 3043621 gccaaagccg ctgccgcttt cagctcctgc catactcttt cctcatcacg ctcgtaagga 3043681 ggaatgcttt cttttactcc ataatggaga aaataaggcg taagcccttt atcgaataca 3043741 atgttttcag gagcgacaat caaattcagc ctcgacagat tgtgctgctg tacggcttga 3043801 acaagctgat aggcaaactg ccatttactt tttttatcct tagctttcat gaagcggaat 3043861 gctttatagg aggagggagg ttggattgtg atgattactt catcatccgt cacatcgatt 3043921 tctttatgaa aaaatggatt tatatctttg atcacgttag cttcaagacc gtcgagaagc 3043981 tttatttttt cccgttgaaa ggtaaatgta tagccggcat ctgttttctc ggcaacagct 3044041 tctaattggt tttctaaata tgatttttgt tcacctgaca ttcaaccaga tcctttcata 3044101 atatttcaag ccggtctccg tttgtaatgc cgcaatcaga cagcttgcat tctccggaaa 3044161 acaccttatc cttgttcacc actctgatcc agtgcccttc gcgcggaggc atagatacgc 3044221 tttgggcctg ccaagcaata tcaattactt ttttcaccgg gtggtaatct gacaatctga 3044281 gatcaaagac actgccgtta taatgtttca aatctattgt aatatcaata tacatttagg 3044341 atcaccctta catagaaaga gcgccgtctt cttttgaatc aggcgctcct tccctttcat 3044401 actgttatcc gcggatttga tttgcgatgt cttggtcagt agactcaagt gtatttgctg 3044461 tttgatcaag ctgctgattc acatcttgaa gcaaatctga cattttgata aatgaaggtt 3044521 tgagctgctc gtattgatct gcgaacgctt cgcttgaagc accttcccac atgcttttca 3044581 aatcagagat cattcggttt aaacgatcaa cctgatttaa tacttcttgg ctttcaacgc 3044641 cgtattgctt cgccatcgct cttagctctt cgggtgtgac acgaattaat cctgccatat 3044701 tcctcattac ctcctgtgcc atcagcctaa atatgggcta attcacttat ttttagaacg 3044761 tcattattat aaaaacagtt tttcggcata gtcaaacaaa tatgttttaa ttttacaaaa 3044821 tgagtccaat ggtttacccc gaatcactca aaaatgacat atactgtaaa gtaaataggt 3044881 ttattttctt aatcttctct tcattctccg aataatccaa aagacccaaa taactctcca 3044941 actcccaaaa aaaacctttc agaaaatttg atgctacagc accatttctg aaaggttcag 3045001 ttttttcttt ccttaattag tcttgcctcc gatgactttc ttagaagatt aataggataa 3045061 gctgtcgtat tatatgagac atacactgtc ctgcaaaaag gcgattacac cgccaaatgt 3045121 atatagaacg tttctctcat gaaattgttt ttttgcttct gttctttgtt gttgattttc 3045181 acaaacaaca acaatcataa taaaaggaag gggatgagat gtcaaagaga aatcaagcac 3045241 gaaaagtagg gagatttatg accatgccga atgatccgtt taaatatagt tttgacagac 3045301 ttgaagatgt ggctgatcat atcagcgacg ttctgcggtg cccgatcacc atagaggatg 3045361 ttaaccacaa gctgcttgcc tacagtacac acagcgactg cacagaccct gcccggacgt 3045421 ctaccattat tggcagaagg gtaccggaga aggtgattaa caagctgtgg aaagacggga 3045481 caattcctgc tctcttaaaa acggaccagc cgatcagagt caagcaaatc gatgaagtcg 3045541 ggctgagcaa tcgcgtcgct atttcgattt ggaaaaacaa gcaagtactt ggcttcatat 3045601 gggcgcttga gatccaaaaa acattgtccg atgaagatct gctgacattg caaatggcag 3045661 caaaagcagt gaaaaacaag cttctcaaac ttcaaatcag aaaaacgaaa aatgaagaac 3045721 gcagccaaga atttttctgg aaaatgctga ccggacacat ccatcaggag gatgatatgg 3045781 cggatgggtt ccataagctt ggaatggccg ctccttcaga gttttccgtt atgatcatcc 3045841 gcataaatgg cgagctgact gaaaaaatcg aacagcagct gcaatattta caggaaacga 3045901 cccagcaggt ttacgtgctg ctggcgaccg tagattccaa tgaacttatt atattaacct 3045961 cacccaaaac agatcatcct tttcaagatt taaaacagtt tgctttaagt acgcaaaaac 3046021 agctgaagga gcggtataaa atagaagacg tttctatcgc ttttggcgga atatacaact 3046081 ctatttcttt tgtctcccgc tcctatcagg aagcattgtc cgtcttaaaa acgaaggaac 3046141 ggttcgctga agagaccaaa catcttttca gcttttctga gttaggcatt tatcaatact 3046201 tagatgtctt aaatgaaaaa cggaaacagg cgggccatta taattactcg ctttccaaac 3046261 tggaacaata tgaccgggat caccagtcaa atatggtaga gacgctagag cgctttattg 3046321 aagcggacag caacgtgaat accgcttcca agctgttaaa tatacacgtt aatacgttga 3046381 attaccgact caagcggatc agccagatcg ctgaaattga tttgaaaaat gtgaatcaaa 3046441 aattcaccat ctatttagat atcaaacttc ggcacatgga tttgtgaaat ttcacaaatc 3046501 catgtttttt tattttctta atcaaacaaa gaattttcca aaatatcaag ctacactaaa 3046561 aatatcacat atacaggagg agacagatat gatcataggg gttcctaaag agataaaaaa 3046621 caatgaaaac cgtgtcgcat taacacccgg gggcgtttct cagctcattt caaacggcca 3046681 ccgggtgctg gttgaaacag gcgcgggcct tggaagcgga tttgaaaatg aagcctatga 3046741 gtcagcagga gcggaaatca ttgctgatcc gaagcaggtc tgggacgccg aaatggtcat 3046801 gaaagtaaaa gaaccgctgc cggaagaata tgtttatttt cgcaaaggac ttgtgctgtt 3046861 tacgtacctt catttagcag ctgagcctga gcttgcacag gccttgaagg ataaaggagt 3046921 aactgccatc gcatatgaaa cggtcagtga aggccggaca ttgcctcttc tgacgccaat 3046981 gtcagaggtt gcgggcagaa tggcagcgca aatcggcgct caattcttag aaaagcctaa 3047041 aggcggaaaa ggcattctgc ttgccggggt gcctggcgtt tcccgcggaa aagtaacaat 3047101 tatcggagga ggcgttgtcg ggacaaacgc ggcgaaaatg gctgtcggcc tcggtgcaga 3047161 tgtgacgatc attgacttaa acgcagaccg cttgcgccag cttgatgaca tcttcggcca 3047221 tcagattaaa acgttaattt ctaatccggt caatattgct gatgctgtgg cggaagcgga 3047281 tctcctcatt tgcgcggtat taattccggg tgctaaagct ccgactcttg tcactgagga 3047341 aatggtaaaa caaatgaaac ccggttcagt tattgttgat gtagcgatcg accaaggcgg 3047401 catcgtcgaa actgtcgacc atatcacaac acatgatcag ccaacatatg aaaaacacgg 3047461 ggttgtgcat tatgctgtag cgaacatgcc aggcgcagtc cctcgtacat caacaatcgc 3047521 cctgactaac gttactgttc catacgcgct gcaaatcgcg aacaaagggg cagtaaaagc 3047581 gctcgcagac aatacggcac tgagagcggg tttaaacacc gcaaacggac acgtgaccta 3047641 tgaagctgta gcaagagatc taggctatga gtatgttcct gccgagaaag ctttacagga 3047701 tgaatcatct gtggcgggtg cttaattcac aataagcttg cagaaagatt tctgcaggct 3047761 tttttatttt ttaaaaggaa aaaagagacc atttcacgaa ttatgactat gaagttgatc 3047821 ataaaggagg attcatatgg ctgttcagca atatggcgtg ttaaaaggca tagtattaga 3047881 catgaagcgg gaaacagatg atgacagtcc tcatttccaa gtcaaaatgc tcggtgaaga 3047941 gaatacgtat tacaggtgcg ccatcaatgt gatgtccagt tctgaggaat ctgaagtatt 3048001 gtatttggct gacgatcagt ttgattcggg ctcaattacc atccttccga acatgccgta 3048061 tggatataca aggatcaatg aagcaaaccg tgaagtggca ctggattatg tgcggggcaa 3048121 tttgtttgac ccgcgggaaa tgaagccttt gcctcatgaa atcacgggac ctgataatga 3048181 tttaaatgat tttattgaaa cctatatgaa gaaagcacaa gatgagaaaa cgccggttta 3048241 tatattcggt tcaaaattcg gccctgaaca ggctgcagat aaaatattcg gctttacccc 3048301 gactaacgga atgcacaata tccatatgaa tcaagggaat gcaatggata cccgctggaa 3048361 aaaagacaac ggctcttggc atgacggggg tattctgatt cagtttgcag atcagtgggc 3048421 cgctgtgttt ttagcgtttt tatcccaatc ttggtgtacc gatgaaaacg gaaaccctgt 3048481 cagagattgt gatcataccc aaacgtctgc gtaagataga aaaagagact gcggcaagca 3048541 gtctcttttt gataagatta cacattttca acagtcttta ggctgtttgg cctcatatcg 3048601 ctccaatgcg attggatata gtccaaacaa gcttcacgcc ctttttgctc atgaacgact 3048661 gtccagccgc tcggcacatc tataaaaccc ggccataggg aatattggcc ttcttcattg 3048721 accagcacca aatatgtgcc atccgcattt tcaaaaggat ttgccattct atttctcctc 3048781 ccttatttat tcaactcttc caatttgaca gcgagaacct tgccgatttg agccagaggt 3048841 tcaggctgac ataaatcttt atgacggcag tcgatgtcga tttgttcaat ctgtccgtta 3048901 atataaggct tccacgagtc aggttcaatc gggtcaaacc attcaggaat gattgttgat 3048961 ctgaaaaaca aaacatttcc gcggaaggtt ttcggcttat aggaacctaa aatgccgaca 3049021 gaatttacat acgtattctt caaatttaaa atgaccgttt catccaggct cgcaagcgca 3049081 ctgccgtcac ggcgaagaat ctcaatcgcc gcttcaaaat ctagcggttt ttcccctaag 3049141 ctgtctggat catacccgcc taacgccaga agggcaataa gcgcttcctc atcatccggt 3049201 gcctctttta taggaaggaa gtggttcgga taggcgtcca gcatcaccaa cagggatact 3049261 tcttctcctt gattttgcag ctgggtagcc atcgcttgaa cgacattccc gcccagggac 3049321 cagcccagca gatggtacgg gccttttggc tggaccgttc ggatttgttt aatgtaatcg 3049381 gcagccatgt catcaagtgt tttcggaagc tcctcgcgct gcccgattcc ccgtgcctgc 3049441 aagccgtaga tcggataatc tgttcctata ttggtcatca aaccggcata acaccagctg 3049501 agcccccctg ccggatgaac acagaataaa ggaggcttgt ctccgcttgt tcggagcggc 3049561 agcagaacgt caagagcgct ttggcttgat cccatttcaa gtctttcagc gagcccggct 3049621 acagtaggtg cttcgaacaa gttgccgatg ctgagttcaa cgccgagcgc ttcacgaatg 3049681 cggctcatga gctgtacagc aagcaaggaa tgtccgccta aatcaaagaa acggtcatca 3049741 atgccgacac gcggcaagtg aagcacctcc ataaagaggt cacagagaat ttcttcctgc 3049801 ggcgttctcg gtcctcgtcc tgtcactgcc gctgcgaaat ccggagcggg cagcgcttta 3049861 cgatcaagct ttccattcgg tgtcagcggc aattctttca tcgtcacaaa ggcagcaggc 3049921 accatgtaat ccggcagtct ctcagcagca tatctgcgca gttccgccgt atcaaatgtt 3049981 tcttccgaag ggatgacata agctgctaac cgtttatctc ccggctgatc ctcacgaacg 3050041 atcactgccg catcttcaag ctgcggatgc tgaacaagcg cggcttcaat ttctcccaat 3050101 tcaatccgga atccccgaat tttcacttga tggtctgcac ggccgacata gtcgagagaa 3050161 ccgtcagcgc ggaggcgggc cacatcccca gtgcggtaca tccgggtgcc tggaggaccg 3050221 aacggatcag ctatgaagcg ttcagatgtt aaaccaggcc ggcctagata acctcgtgct 3050281 aaccccgctc ctgatacata cagctctccg gcaacacccg gcgggaccgg ctgcaggcgt 3050341 tcatccagca cgtatacacc aagatcggga atgccgcagc cgatcaagct gtttgcccgt 3050401 aaagctgcca tgcttcggtc taattcgata tagctcacat gcaccgtcgt ttctgtaata 3050461 ccatacatat tgataagctg cggtctattt tcagggtggc ggttgtacca atcctctaaa 3050521 cggctgagtt caagcgcttc tccgccaaaa atgacatagc gcagactgag tgcctgtccg 3050581 agatccggct gttcccgttc cgcctgcata aactgataga aagcagacgg tgtctggttc 3050641 agaacagtca ccccctcttt gacaagcagg cgcagaaacg cttctggcga tctgctgacg 3050701 tggtgaggca cgattacaag acgtccgcca tgcagcagag gaccccagat ctcccacacc 3050761 gaaaaatcaa acgcatagga atggaacatg gtccagatat cacctgagct gaaacggaac 3050821 cagtgctcgg tcgctgcaaa taaacgtgtt acattttggt gaggaatcat cacacctttt 3050881 ggaacacctg ttgagccgga tgtataaatg acatatgccg tattcaaagg ggaaagcggc 3050941 tgagtcctat ccttattttt tggattacct gcagggtacg tgtttagttt ctctgccagc 3051001 tcgggatcat ccagcacgat tttcggcacg ttttcaactg gcggaatgtg atttgcagct 3051061 ttagtgttcg tcatgataaa cgcaggctgt gcatctttta gcataaaagc aattcgatca 3051121 gccggataat ccggatcaag agggagataa gctgccccgg cctttagcac cgccaatagg 3051181 ccgacagcca tttccaacga tcggggcagt gccaatgcca caaattgctc cggcccgaca 3051241 ccttcactaa tcatcattcg ggcaagccgg tttgctcttt cattcagctc tgcatagctc 3051301 agttcctgat tttcatatac aacggcaatg gcatcaggac gtaaagcagc ctgcttctca 3051361 aattgctctg gcaaacatgc gtgcggaatc ttttcagata cactttgcca atcagtcacc 3051421 atgctgctgt gttcctctgg cgcaagaata tccagatttc cgatttgctc gtcaggatca 3051481 gactcggcag cctccaacag gcgcatcaat cggtcagcaa gagcctgagc agtttcccgt 3051541 ttgaaaagat cagtgctgta ttcaagcagt ccttccattc cgtttggtgt cccgtcagca 3051601 aggcgatctt cactaatttc cagcgtcaaa tcaaacttgg cagaaccgac actgttgatt 3051661 cgcaggctgc tctccatatc aggaagatgc agttcagcgt ccggtgtgtt ttggaacgca 3051721 agcatgattt ggaataaagg atgcgtcgca cgcgaacgag ccggattgag cacctctaca 3051781 agtctctcaa acggcagatc ctgattgtca taggcggcca gattcacttc ccgtactctg 3051841 tctagaagct cacgaaagct tgggtcaccg gacgtatcag ttctgagcac caatgtatta 3051901 atgaacagcc ctacaagatc gcccagcgca tcatcattcc gtcccgcgat cggactgccg 3051961 atcggaatgt cggtgcccgc cccgagcctt gtcaataaag cggcgagacc ggattgaagc 3052021 accataaaca ggctcaccct atttgcgcga gccagctcct gcaatcgctt gtgaaactcg 3052081 ggctcaatac gaaaatgaat cgtatctcca tcatgactcg gctcagccgg acgtgaataa 3052141 tcggttggca gttcaagctg atcaggcagg tttttcaagg tttctttcca gaaagcaagc 3052201 tgtccggcaa tcaagctatt tggatcatcc tcgtttccaa gcagttcttg ctgccaaagc 3052261 gcatagtctg catactgcac agcaagaggc gcccattcgg gagatcgtcc gtggcagcga 3052321 gccgcataag ctgtcccaag gtctctggtc agcggtgtta aggaccagcc gtccccgaca 3052381 atatgatgga cgagaagaag cagcacgtac tcgtcaggac cgatcacaaa aagctcggca 3052441 cgaaaagcag gttcagctgc aagatcaaag ctgtagcgta cagcttcggc aagccgatca 3052501 gaaagctcct tctcagcaat ttcagtaaca tgtaactcgg gacaggctcg atcggcatct 3052561 aaaatatgct gataggatgt cccctgtgat tcagggaaga tcgtccgaag actttcatga 3052621 cggcagacga ggtcataaag tgccgctttc agcaatcctt gatccaactc acctgacaaa 3052681 cggacagcaa ccggaatatt ataagtagga ctcggtcctt ccagacaatg caggaaccat 3052741 agccggcgct gggcaaatga gagcgggatc ttttcaggcc gctcagctct ctgcaaagcg 3052801 ggacatgcac tctgcgccaa atcaagatgg gcagcgagtc cggctactgt cggttcgtca 3052861 aagagcttgg cgataccaag ttcggctccc attacctcgc gaatgcggct catcagacgg 3052921 gctgcaagaa gagaatggcc cccaagctcg aagaaactgt catcgatacc gacgcgtgcc 3052981 aaaccgagaa cctctgcaaa caagtcacac aatatctctt cctgaggagt ccgcggggcc 3053041 cgatcactga cagatgtgct gaagtctggt gccggcagtg ctttccggtc aagcttgcca 3053101 ttaggtgtta acggcagctc gtccatctcc acaaacgccg acggtaccat ataatcagga 3053161 agactagccc ccatataacg acgaagctct gcagtatcaa tagcagcatc agcgactaca 3053221 taagccgcca atcgtttgtc tcccggctga tcttcccgta cgacaaccgc ggcctgttca 3053281 atgtgcgggt gattggcaag cacggcatca atttctccaa gttcaattcg gaatccgcga 3053341 attttgattt gatgatccgc ccgcccgata taatccaaag acccatcggc gcgccagcgg 3053401 gcctggtctc cggtccgata catccgagtt cccggcggtc cgtatggatc tgcaacgaag 3053461 cgctccgccg ttaaatcagg acgatggaaa taacctctgg ccaagccggt tcctgcaata 3053521 taaagctctc cgacaacgcc cggcggcacc ggctgcaatc cattatcaag cacatacacc 3053581 tgcgtgttcc aaatcggttt cccaatcgga ggaacgccct tcagcccttc ttcaagaaaa 3053641 gctgcggcag accaaatcgt tgtttcagtg ggaccgtata agttcgtgac tgaacaatga 3053701 aggtcttgaa gttcctgcaa aagaccgctc ggcagcgcct cgcctcctac aagcactcta 3053761 agcccccgaa gtttctcagg ttcactcgtt accaaagcgt gccacagtgt cggtgtcgcc 3053821 tgcataatgt taatatcgaa attttcaatc atttgagcta atgcctgcgg ctcacggatc 3053881 gtttctttct ttgcgatcac gatttgcgct ccgctaatca gcggaagata taactccaat 3053941 gctgaaatat caaaagcgac agtcgtcaca gccaacagcc tgtcttcttc tcctagagaa 3054001 aatgcctcct gcatagacag cagaaaattg cttaagcttt tctgtgtcac aacgactccc 3054061 ttcggtcttc ctgttgatcc tgaggtatag atgatatacg caggatggtc aagcgaaacc 3054121 gatacatcct gattttccgg cgaatagcgt tttataatct cctgtgtaac agcctgatca 3054181 agcacaagct caggtacagc caggtcatca ggcagactgg ctgctatttc ctcagtcgtt 3054241 atgatgcatg aaggtttcgc atcctccagc atgtaagaaa tgcggtcggc tggaaactcc 3054301 ggatcaaggg ggagatacgc cgcaccagtc ttgagcacac caagcattga agccaccatc 3054361 tcaggggaac gcggcagcgc caaagcgaca aattgctccg gaccaatccc tttttcgatc 3054421 aacagacgcg cgaggcggtt tgcctcttca ttgagctttc gatagttgac ttgaatgtca 3054481 tcacacatga gagcgatacg ttctggcgta agaactgcct gcttttcgaa catgtcctga 3054541 aggctgacca gcttctcgga ttttgccgtc tcattccatt tagaaatgac tttttctttc 3054601 tcctctggca acagaagctc catttgccca atcagcatgt cctctccggc agaagccgtt 3054661 tgcagcagct gcaaaatacg ctgctgatga agcttaatat cagactcact gtatacctcg 3054721 ggattcgcat caacatcaat tcgcagcccg ctgccgtctg ttctgtcata tacattgatt 3054781 gatagatcat caacaggacc ggctgaaaga ttatgcgttg tgccccggac gccggcaaag 3054841 tcgagaccgt aatcaaacgg cataagattg atttgagggc caaataatct atgattttct 3054901 cctatcaatt tcagatcgcg cctaagctct tcatggcgat acttatgatg tcgccgaata 3054961 ctgcggattt cccgggaaat ttgctgaatc agttcagaaa agctcatcga agagcttacc 3055021 gtcagccgga gcgggagaag gttcatcacc atagccggta cattcagtga cgcggaccct 3055081 atccgaccca tcatgggcag gccgagcaca acatcctcag agccggtcat acggtgcaca 3055141 taaacagctg acaccgcaat catgacttca tgccagcttc ctgagaaata gcgcgccgct 3055201 tcttttaacg cgtttacatc agacggaggc agatatgccg tatgacgaag aaaactgtta 3055261 gatgttcttg gcgcccgatc agccaagctc acaacttcag gtgcatctgc aaaacggtcc 3055321 agccagaatt gacgatcctt ctcatactgc tctgatccgc gataatctgt atcctcctcc 3055381 aaaatggcct ggagagaccc aaaggaacgg cttttagctg tttgtccttt tataagggca 3055441 gtatatgtac ttgccacacg ctgggctatc agggaaaaac cgaagccgtc gatcgctata 3055501 tggtgaatgc gctgatacca aaagaaacga tcaggcccgg caataaacag agcttcattg 3055561 aacaaagggg cataccctaa atcaaccggc tttgctaaat cagctttcat ccagtttaat 3055621 gctgtttttt ccggatcagg ctcagagctg acgtcaatga cgtgcagctg tacatccgga 3055681 gacgggttta tcatctgcca aggcccgtcc atattttcac cgaagcggac atgcagcgat 3055741 tccgcttcct tgatcacgtg ccgcaaagct tcttcaaaaa gagcaatatt gactggtcca 3055801 ttgatttcta tatattccgc tgtattgtag attggattgt ccggatcaag ctgctgagca 3055861 aaccatatgc cagtttgcgc cccggtcaaa gaatattgaa gatcttttgt atcaggcatc 3055921 cgtttgttta ccctcctttt ataaataatc cgcgtttggc agcacttgct ggctgcgagt 3055981 tgtgagcaat ttctgccatt cttcgatcgt tgggcgttca gccaattcca cgaaagtcac 3056041 ctctgcccct tcacggcgcc attgttccac caatgtcatg atccttaccg aatcaagacc 3056101 acgatcgagc aaatcctctt gatctgtgat gtcttccggt gtttcttgta gaagctcagc 3056161 aatttgttta cggatattct cacatgtaaa cacgttcttt ttgccagtgt ttgctgacgt 3056221 tttttgaacg tctgccggcg cattctgcag ctgatcaaga agactgtcag tcatcacggt 3056281 aaacgcacag cgtccagccg catattccag cgccatttga tgtttttcta atgaaaaatc 3056341 agcaactgca tctcccacaa aaaaggcttt aatatcctcc ataaatgctt cacatgctgt 3056401 aacaagacag ccgatatggg cgtaaattcc tgtaatgatc agctgatcgc gtccctcttt 3056461 gcgcatcatt tcaagcagat tcgttctctt aaacgcgctg tatctccatt ttgtcagcac 3056521 aagatcatca tcctctggtg ccagctcggt tataattttc tcctcataag gaccgctgtt 3056581 taatcccggg ccccaaaagt ctgtcagcag cgcacggtca tccggatttt ggcttcccgg 3056641 ctgtgcggta tagacaacag gaatcccaag ctgaacacat tgattcttca gctttcgtat 3056701 attcgctgaa agctctgtta ccggagacgc tcccgctgtg aaagcatcaa caaaatagtt 3056761 ttgcatatcg tgtattaaca agacagcccg attcggatca ggcacccatg atactttgtt 3056821 ttgcggcata tcagatgctg tcggcatttg atacggctga atggcaggta tagccatatg 3056881 aacacttcct ctcaaattgt tgttttattt tttaaatcct gcaagaagct tctcggaaat 3056941 ggcttcacgg agcgcttttt tgctgacttt tcctactcct gtctgcggga aggattcgac 3057001 aaattcaact cgatcaggga ttttatatgc cgccagtccg cgctctctca aaaatgcttt 3057061 aagctctgcg gcttttgggg cttcatcccg gggaataatg aacacacaag atctttcgcc 3057121 aagaaattga tcaggcatgg agaccattgc cgcatcatgg acagccggat gcgccagcag 3057181 atgattttct acctcttcag ccgcaacctt ttctcctcca cggttaattt gatccttcgc 3057241 ccggccttca acgacaatat agccgtctcg tgtcagcctg acgatatcac ccgtacggta 3057301 aaaaccgtcc tcagtaaatg aagcggcgtt atgctcttct gccttatagt aacctcgaat 3057361 tgtatacggc ccccgcgtca gcagatggcc tgtttcacca ggttttacgt cgcgatcatg 3057421 atcatcccaa acacgcattt catcatatgg agacatcggt tttccttggg tgttgacaat 3057481 gatctcctca ggatcatcca atctcgtata attgacgaga ccctctgcca ttccgaacac 3057541 ctgctgcagc gtgcagccga aaacagcttt taccctgcgc gcggcttcag cactaaactt 3057601 ggcaccgccg acctgcagca cttgaaggct ggataaatca tcacggcgtg aggatgccgc 3057661 atccatccat accatcgcaa gaggcggaac aagagcggtt atcgtgacct tttcccgttc 3057721 aattaaagga aatgcgtcat ctggacttgg agaaggagat aataccactc ttcctccagc 3057781 gtataatacg ccgagaacgc cgggtgagct cagcggataa ttgtgtgcca tcggcagcgc 3057841 ggccaagtac accgtgctgt ggtcgagcca gcagacctcc acactccgct tcaggctgta 3057901 tatgtagtca tcgtgggtcc tcggaatcag tttcgatagc ccggtgctcc cgccagaaag 3057961 ctggaggaac gccacatccg atgatttgac ttcaggcagt tttacaggtt ctgcatgcaa 3058021 atcctccagc ggtaaaaatt cctctgcctc acctgcgaca atgatgtttt tcaaagtcgg 3058081 cagcttgctt tgaacctgtc tggcaagcga acggtagtca aaaccggaat aagcgtcggg 3058141 aatgatatat gcagccgctt cagcaaactc gcaaaaatat gtaatttcac tgcttcgatg 3058201 agaaggcagt gcgaagactg gaagcgcccc cagacggaaa agcgcgaaaa tgacttcaaa 3058261 aaactctttg atatttggca actgcaccac aacacgatcc atctgttgaa tgccgagctt 3058321 ttgaaatccg gcagccaggc gatcagccct tgtgtcaagc tctcgatagc tccaatgggt 3058381 gtttccgcat gtaatggcaa tgcgatcacc atatttggct gcccggtccc ttaacaaatc 3058441 tccaaacgtc tcaccggccc agcagccgtt ctttcgatag gtctcagcta actcatcagg 3058501 ccaaggcgta aatcctttca gcatgttgta tccctccagc aattcattct gttcatatgt 3058561 gatccacgcc cattgcccgc agcattgtcc gaaactttgc ggacgtctcc tgaagctcgt 3058621 cctcaggctt tgaaccggcc acaacaccag ctccagcata caggcggagt gagcgttctt 3058681 ctgcttctgc acaacggatg gtcacgatcc attctccgtc accggcatcg tcacaccatc 3058741 cgaccatgcc ggtaaagaaa ccgcggtcaa atggttcaat gctgagaatc gcttctcttg 3058801 caagatcagt cggtgttccg cagacggctg gcgtcgggtg gagcgccgcc gccaattcaa 3058861 gtgcggttac agacgggtcg gaaagctctc ccttaatcac gctggacagg tgccacatcg 3058921 tttccgtttt gatcagtgaa ggcttctccg gaacctccag cgtccggcag aaaggtctca 3058981 gcgctgccgc aaccgcgtca gcgacaaccg cgtgctcatg aagatccttt gcggaagaaa 3059041 gcaattcagc tgcccggcgc tggtcttcaa caggatcatt actgcgcggt cttgagccgg 3059101 ctaatgggtt ggaaacgacc tgtgttccca tccttgaaac gagaagctcc ggacttgctc 3059161 cgagcaatgt tctgcgggga gacgtttcct cctgactgga cacgtctgcg gcaaacgtgt 3059221 agccatgcga gttatgctga gccagatggc gaagcaattc atccgtctga atcggttcag 3059281 gcgatgtcaa atgcagcgat ctggacagga cgattttgct gagtgttcca tcggcaatgc 3059341 gtgccagccc ttgttcaaca ccatttttat aatcctcagg ttcaggaaca ggctttatgt 3059401 ggtatgtatg cccagcctgc tgttcctttt cctcatgatc aaattgaagc ggtcctgacc 3059461 agcgcacttc ttcaggtaca acgagccgcg ctgcttttac ttgatcaaaa ggaacggccc 3059521 cgacaacaag cggccggctt tgccctgatt gttttgcctg acgtaacgcc tctgcaattc 3059581 ggccagaaag ggtttccatt tggttttgcc cgtctgcctc cggtacaatt tcacatatgc 3059641 ctttcgctaa cagtacacga tgaggagacg ctaagaaaaa ggcgcccggc tgatattcat 3059701 gaagcaaatg ctccgctttt gtttctgtta taacgttttg atccaacatt ctcatgaacc 3059761 tcctttaaat tcagttacac gcctaaggtc gcgccgccat ctacgcataa attatgcatc 3059821 gtaatatgcc ctgcctggcc agaaaccaaa aagagcaccg catccgcaat atccgaaggc 3059881 ttggctagtt ttttgagcgg gatccctgtt ttaaatgtct caagtgatcc ttttatgact 3059941 tgctccgctc cattctcgtc ggcccataat gaccactgca tgtctgtttc cgttgatccg 3060001 ggagatacaa tgttgcagcg aatattgtat tctgcaagct caaggccaag gcatttcgta 3060061 aacatcacag ccgcagcctt tgaagacgca tatgccgcca tagatgttct tggtacaccg 3060121 gcagcattcg atccgactgt tacaatcgaa cccgatcttc ggtccatcat atatttgctg 3060181 actgaacgcg aggcgttaaa tacgccagtc gaattcactg agaacgtcgc ctcccattcc 3060241 tcatcgctaa gcgaatggat cagtcccggg cgaaggacac ccgctacatt cactaaaata 3060301 tcaatcggcc ccatttcacg ttcgatgcgc gccgtgatct cgtcaatcgc cgcgctgtct 3060361 ctcacatccg caggaaaagc ttctgcatgg cggccttctg ctttgaggct gctcacaacc 3060421 ttttccagct tttcaggatt ataatcaact gccgcaatat gtgcgccttg actggcaagc 3060481 gtccgcgcaa cagcttcgcc tattccttgg gcagcccctg ttataaaagc aatttttccc 3060541 tctataccct ttgcattcat atcatcaatt cctttcttcg ctctaaatgc caaacagaca 3060601 tccagcgaaa aagactgctg cgccttgaaa aacgcaatct attgataatg attatcatta 3060661 tcaattataa aaataatcat atccaaatgt catgtgacag tcaaatataa tttcagtgac 3060721 aaatattttt ttaaaggcaa ggctgagtat gtctcagccc attgatagat gcggtccgtc 3060781 agggtgaagc gcaaaacgca gcgccctgct gaccaaaaca ggaagaactg aaatatgtcc 3060841 ttctcctgaa aactcgcaaa attctgcccg tataccttgt tcagataaaa cggccagccg 3060901 ctcataaagc tcccttgcat tatcattcat ccggctttta tgatgctgct ctaattctcc 3060961 tgcggcaagc aggatattga taggctgatt gtttttcttg gtgagagaga cgaaatggtc 3061021 cgttttcttg agaataaacg gtttattcca atgaatggac ggacttcccg cgatatacgt 3061081 ttgaaacgca tcgggctttg ttagcagcac ctgcagcacg aaaagccctc cgagcgaatg 3061141 gccaaagatt gtttgtcttt ttttatcaat ctggtaatct cgttctatct ccggttttaa 3061201 atcctcttca ataaatctga aaaagccctc cgctccgcca tgctccggcc attctctgcc 3061261 gtcgggcctt tccggcagct tcgattgggc tgttggcatt gtaaaatccc ggtggcgtgc 3061321 tgaggagaac ggctccgctg tctcatagcc aatgccgacg atcactgcag ggatcacccc 3061381 ggttttttcg ggtcggcgtc cctgtattcg aacggcttcc gtcatcgttc cgaagacaga 3061441 attggcatcc agcagataaa tcacaggata accagcgggt ggcggcggcg tactaggttt 3061501 cgagataaaa atgtgatagg tacggttttc attgcgtgaa gacatcatac gcacttccgt 3061561 accaggaatc gtaaatgcgt ttgatgtccc gccatttgtc cggtctgttg tttgttcttt 3061621 catgcagtac gacattcctc tccttaaact aaaccgcaat gtatgataat gattttcact 3061681 atcaactaga cacctcaaat aataggtttt cttccaaaga aagtcaactt tttcccgaat 3061741 aaaaaaggca ccttgatcaa ataaggtacc tgcagactat caatatggaa gtaaaaacct 3061801 aataaagatg cgtattgtcc tatttgaaat agaaccttaa tcccatgtaa acctttgatt 3061861 ttgccaaggg tcgcctctca tgtgatagcc attccgctcc caaaagccag ggtgattttc 3061921 tttcgtaaat tggatgccgc gcagccactt ggcgcttttc caaaaataca gatgcggaaa 3061981 tacaccccgc agcggaaagc cgtgttcagg ggttaaaggt tcgccattat gcgcataagc 3062041 cagaagggaa gtttccgcta agaaatcatc aagcggcaga ttggtcgtcc agccctcttc 3062101 agcatgtaaa atgacgtagc ccgcttcttc ttttacaccc gctttttccg ctatatcaca 3062161 agcccgcacg ccttgccaca cattatcaag ccttgaccat cccgtgacgc aatgaatgtc 3062221 gtttttcgat tcataccgtg gaaaggcttt gacatcttca aagcttagca gcatcggatg 3062281 gtcaaccaaa ccgtatactt gaagattcca tttcgtcata tcttcgtaat atgggacatc 3062341 tccggtatga agcacaggaa atgaagtggt gacgttttga tttggcggca ctcttccaga 3062401 ttgatcggac tgtcttgttt ttccgaaata catatgggcc tcctttttgt taacctaatt 3062461 taaaatcatg ttgacaatct ttttgttctt tattactcta tgattgtgta tgtcaaccta 3062521 agggggaaca acgatgaaac aacgtaaact tcgtgcggga gatatggcgc tgattggcat 3062581 gttcgccgca cttatggctg tcggggccaa cattacatca gtagcaccct ttttacaagt 3062641 agccggcatt ccgctttcga tgcagccgtt tttctgtctc ttggcagctt tgcttcttgg 3062701 cagcaaacgg gcagcgattg ccatgattgt atatgcactt gtgggattgg ccggagcgcc 3062761 tgtgtttgct caattttcag caggcttcgc accgtttgca gggaaaagcg gcgggtttat 3062821 tatctcatac attccggcag catttgcagc gggatggttt ttagaacgaa acattcagcc 3062881 aagtaaaatt cgatttctca ttgcttcact tatcggaacg gcgatcatgt atctcatcgg 3062941 cactacctat atgtatcttg cactgaagct gtggattcat acgccagtga gctacggcac 3063001 ggcttggggc tttatgattt ggtttatggt aaaagataca gcgctggctg tgatactgtc 3063061 gtttatcgca ccagcaatct accgctctat tcataaagca accggcttta acagaaatca 3063121 catatcatct acgtaaaaac cgttctattg gacggttttt ttatcataac gagaaaaggc 3063181 tccccagtaa aggggagcct ttttcctata aaacaagcgc tgcaatccag ccaaagatga 3063241 caagcggaat attataaaat ataaatgtcg gcacacaagt atcccaaatg tggtgatgct 3063301 ggccgtccgc actcaaacct gaagtcggcc caagcgtact gtcactggca ggtgaaccgg 3063361 catcgccaag cgcagcagca gccccgataa tcgcaatcgt tgccatcggg ctgaatccaa 3063421 gctgcatgca tagaggcacg aaaatggttg tgataacagg aatggtcgca aaagaagatc 3063481 cgatccccat tgtaattaat aagccgacaa tgagcatcag caatgcgccc aaggactgac 3063541 tgtgtccgat aaaaccagct gacgttttga ccagtgactc gacatctccg gttttcgtca 3063601 atacgtttga aaatccggct gcaacaagca tgacaaagcc gataaaggcc attaaaacca 3063661 ttccatcagt aatcagtgag tccgcttcat cacgcttcat cacaccgctg acaaacagaa 3063721 caatcagacc agcgagcgcc cccataatca ttccttctac tcccaaagtc tgagataagt 3063781 aaagctggac gccgagtgac acaacaatgg ctagaaccgc gataccaata ctttttctcg 3063841 tatatggcga tgcttctgca cctgaaatgt cttttgtttc atattgtttc ggtttacggt 3063901 atacgatcac tgataaaata aggccgacaa ccatacctgc aactggaata atcagtgcgt 3063961 acggaatatc agcaagcgga acgtttaacc cggcatccgc catattgtcc ttcagcatgc 3064021 cttggaagat ttggccgaaa ccgaccggaa gcaaaatata aggagccgtt aagccaaatg 3064081 taattacaca cgcgatcaga cggcggtcca tttcaagttc attaaagatt ttcaaaagcg 3064141 gcggaatcag caccgggata aacgcgatgt gaaccggaac gacgttttgc gaaaaacaag 3064201 atacaattaa aataatcagc acaatcagca ccttagacag tgcttttttt cgagaatctt 3064261 ctttatttcc gattaattta acggaggctt ccaccattgc gtccggaaga cccgttttcg 3064321 tcaaagcggc ggcaaacgcg ccaagcatgg catagctaac tgcaacggtg gcatttccgc 3064381 cgagaccgtc tgtgaaagct ttaaccgttt cgccaagacc gagcccgcct gttaacccgc 3064441 cggccaaggc gcctataatt aatgcgataa caatattgac acgcagcagg cttaatacaa 3064501 gcataagcag gactgcgatg acgactgcat tcatgatgat acccctccaa aaatccttta 3064561 gtttgctaat gtagtagata aataaagtac gaacgtatcg tatcataacc gatccacttt 3064621 agtcaactaa agatttcgga agaaaaaatc cctgccgcat catacagcag ggatttttca 3064681 ttactcgttt ttatcttctt ccaatgtaaa tcgctccgca agtgtagcca gtgttcttgc 3064741 cataacgcca gtagccccgg ccggtccgaa gcaggttgct ttattggcag tcgctgtgcc 3064801 tgcaatatca aggtgaaccc aaggtgttga ctcagcgaat tcaccaagaa acgttcctgc 3064861 cataatcgca tgtccctcgc gtcccggtga attgctgaga tccgccattt ggctgctttt 3064921 cacgcgtttt ttatccttct ctgttatcgg cagctgccag atcgcctcgc cgcactcttg 3064981 tgcagcatca gctacctgct ggtaaaagct ttgatcattt gtcattgcac cggttgtttc 3065041 tgttcctaat gccacaacga cgccgccggt aagcgtagct acatcgacaa gaactgatgc 3065101 gccatgctgt ttcgcgtatg taatgccatc tgcaagcact agccttcctt cagcatccgt 3065161 attaaggatt tctattgttt ttccgcttaa agatacgatc acgtcatccg gcttcatggc 3065221 cccgccggag atcatattat cggttgatgg aataacgcac agcacgtttt gttcaggacg 3065281 aagctctccg atcgtttcca tagccccgag aaccgcagct gctcctccca tatctgattt 3065341 catgccaaca attccagatt tcgttttaat ggagtagccg cctgtgtcaa aggtaattcc 3065401 tttcccgact agtccgacga cgtcttccca ttcctttttg ccctgatatt tcaacacaat 3065461 cattttcggc ggttcggtgg agccttggtt taccgcaagt attccgccca taccgagctc 3065521 ttccatctct gatttctcca atatctcaca ctcaaaatca tatttcgccg caagctcttc 3065581 agcatacgaa gcgaggtcag tcgctgtcag catgtttccc ggcatattca caagcgttct 3065641 agccgaattt gtcccttgtc cgtatgcctg gccgacgcga agccctgcct gcacttcctg 3065701 tgtatcttca tctgttacaa catacacggc ttcaatttgt ttgtcaggct catttgattt 3065761 atgcttataa tcctgcacct cataggaagc aagcaggcag ctctcagcta aagcatgagc 3065821 ggcatcggct ggaggcacgt cttccgaaat aaacgtatca agcagaacag cagtttcttg 3065881 ttttcgatct ttatgaatgg cttgaaaaac atgagcaaaa cgttccttcg cctgttcaaa 3065941 cgaataattt gcttctctcc ccaggccaac gaaataaatc cgtttcatac ccgcagaaga 3066001 tggagggaat acttttgata cttgattcgg tttcgcagag acatcaccct cttttaaaag 3066061 ctgtgtcaga tggccttcga gcatttcatc aatttccaac gcttttcctg tcagctggct 3066121 tttttgaaaa agcccgacaa caagggtttc tgtatgctct gattgttgaa ccgcataaaa 3066181 catgaggctt acactcctaa cgtaatgggt atttgtaatg aacaatggta taataggaaa 3066241 aacattcttt ccactatact tattttaaca aacaacagtc taagacttgc ttttttcttt 3066301 tgaaacacga aggatttttc aaatagaaag gatgtcgccg atggaacttt taacgaattt 3066361 tcctttatta tcaagcctgg ccgcaattat ttttgctcag gtcatcaaag tgcccataca 3066421 gtttatcgtg tccagaaaac tggactggtc gctggtcaca agcacaggcg gcatgcctag 3066481 ctctcactcc gcagcggtca ctgcgctttc tacaggcgta gccttggagc atggattaga 3066541 ctcctcactc tttgcggttt ccgccatttt cgccgtcata accatgtttg acgcaactgg 3066601 cgtcagacgt cacgccggtg agcaggcaac agtcattaat aagcttgtta ttgattttaa 3066661 ccgtttcgta aatgaagcga aggacttccc taaggctgca gagaaagaaa agcaaaaaaa 3066721 gctgaaagag cttctcggac atcagccgat cgaagtcttt ttcggaggat taacaggtat 3066781 tttactgaca ttggtactcg cttacttttt catgtaaaaa aaacgctcct gctttcgctg 3066841 gagcgtttta ttctttcacc gttttatatt gatttctgaa cacttgcaaa gattttgttt 3066901 cattgagctt ctcaagctca tcctcggtaa tctttcccgt tcccttttta atcacatata 3066961 catcaagggt ttttttgccc cattcattgt atacatcttt gactgtctca aagtacagat 3067021 caaggcggtt tcccttaata gctgatcctg tgtcggccac aactccgaga ccgtagttcg 3067081 gaatgaataa aattgttccg atcgggaaaa cggacgggtc agcagcaacc gtggaatata 3067141 aatcccgttt cactttcaca cctgaatatg taagcccgta taatggatca ccgggatttt 3067201 tgcccgtcga ctcagctcct gctgtgtagc ctgttgctgt tactctttgg actggatatt 3067261 catcccaatc aaatgcctct tctaacggtt ttgttttatc ctcagccgcg gacgtggttt 3067321 gtgtttgttt ctgctgcaat gcttttaatc tcagtcctgc atgcttcaag tgcttttcct 3067381 gatgttcctg cacccatttt gacaagtcct tcgcttcaat tcctgacact gataaaaatg 3067441 tcgtgccaaa tgcaagcaga aataaacagg tcatcagcaa acgtctgatc atattcaaca 3067501 tcattcacct ctcctccgaa tcattgttcc caagtggaga gagcattatt caaaatggtg 3067561 aatgagctga acgcataaaa aaagctttct ttagaagaaa gcggcattta aaacatttga 3067621 tatcctcttt ttctaagcat gttgatcgct ataccggaca cgatggcgcc ggccaaaccg 3067681 ctgactaaaa tcagcacatc agcagccgct aatgataaga cacgatgaaa caggctggca 3067741 aaggattctc ccggcgactg gacatagctg atcagctttt ctttgctgat aatgaaaagg 3067801 catacaattg gataaatcac agccataatc caagacattc tcagcagcat gtttaataag 3067861 aaaccgattc caaaaaacaa gacaaaaaac aaaacaattg agatgattac gactggcaga 3067921 ctaatcaacc tattccaccc ccctgcgttg tttttagtgt aacgcggggg ctgaaataaa 3067981 gtcaacggct ggaaaaagaa tgactgtctt ttcctgtccc ctggcaagac ggacaagtct 3068041 ctgaaccgcc gagaatcaat tgaaaatatc ctttccctga acaaaatggg catgcatgtg 3068101 aagcggttgt cgttgcagtt ttcatctaat catcaccctt tttcttaatt ttctgataat 3068161 ataccatatc aagctgtcaa caataaagtc agatcatgtg acaaatcttt tgatgtaagc 3068221 ggaaacatac ttgttttcct ctcgttctct ttttattttg gcgtttttta ataaagaaaa 3068281 cccgcttccg cgggttttta gaaaaacttg aacttgcctt ttttcaatgt cagtccgagt 3068341 ccgccaatca taaacagtga gcggttatca atgacttttt tcataaacga agcgggcgtg 3068401 cctttcagct ttctgccata aacaacccca accgcgttat gctcgccaag agaagccact 3068461 gttcccttaa tgtccggctt gaattcctca agctctccgc ctttaataag cctgccaagg 3068521 tttttagcga ccgttatgcc ctgctgcatt gcaatttgcg cagtcggcgg atacgggcgc 3068581 tctgtatctt cattcataaa cagcgagctg tcgccgagaa taaagacatt gtcatgtccc 3068641 ggggcgcgga gatcagggtt gactttgact cggccgcgca tattctcaaa accggcttcc 3068701 tccacaatcg gatggccgcg gacacctgcc gcccatacaa cggtttgcga tttgatctgc 3068761 tctggttctt catctttttt gccgactctg actccttctg gtgtacattc ttgtacagcc 3068821 gttccgatct tgaactcaac tccgttttcc tcaagataat gtacggcgta atcaacaagt 3068881 tccggatcaa agcccggcaa aacggtcggc gctgcttcca cacaaatgat gcggacaagg 3068941 cttctgtcaa cgtcatattc cttacagagc tccggcacgc gagcagccag ttcgccaaga 3069001 aattcaattc ccgtaaatcc ggcaccgcca acaacgatcg ttaacctgtc cggccgtttt 3069061 tccgcttccg tattgtaagt cgcaaactgc agctcaatat gttcccgcag caggcgcgac 3069121 gtgttgatgt tggcaatcgg aaacgcatat tcttttaagc ctttaatgcc gaacgtttca 3069181 ggcacggcgc cgagcccgat gactaaataa tcgtactgca attctccatt cgcaagcaca 3069241 acttttttct catcaatttt gattgccttt acggtatcct gtacaaaatt cacccgtgac 3069301 tggttgatta catcttttat ctgataacgg cagcggtcat gatggagcgt acccgcgctc 3069361 gcttcatgca tccatgtcgt ttcataatga taattgtgtt tatttacaag cgtaatgtca 3069421 gcatcattcg gcccgacata cttcgtcagc cttgtcaccg tcatcaatcc gccatatcct 3069481 gcacctaaaa tcacgatttt gggcttattc aatgccatca catccacctt ctcttttttt 3069541 gcttttgtta gacccataat aaaatcatca tttgtgttag cttcagctta ttggcgggat 3069601 tttatgaaat atattgaaaa gttttttgtg aagtccttac ccgtagcact attatcatgt 3069661 ttatccggct ggcccaagaa acattcagaa aaagatcatt tcatttggtt attatcgtag 3069721 cggcctgcgg aaatattttc aagaacggat gggcacgtta gatccttacg attttttctg 3069781 ctgactcgtc aatttgaacg gcaatatggt ataattaata acaattttca tttaggaggc 3069841 aattttcgta tgcgagagga tacaaaggtt tatgatatta caattatagg cgggggaccg 3069901 gtcggcttat tcaccgcttt ttacggcggg atgagacagg caagcgtcaa aattatcgaa 3069961 agcctgcctc agctcggcgg acagcttagc gccctatacc ctgagaagta tatatatgat 3070021 gtagcgggat tcccgaaaat ccgcgcgcaa gagcttatca ataacctaaa agagcaaatg 3070081 gcgaaattcg accaaaccat ttgtctggag caagcggttg aatctgttga gaaacaagcg 3070141 gacggcgtgt ttaagcttgt aacaaatgaa gaaacccact actctaaaac ggtcatcata 3070201 actgcaggaa acggcgcatt caaaccgaga aagctggaac ttgaaaatgc cgagcagtat 3070261 gaaggcaaaa acctccatta cttcgttgat gatctgcaaa aattcgccgg cagacgcgtt 3070321 gcgatccttg gcggtggaga ttccgcggtt gactgggcgc ttatgcttga gccaatcgca 3070381 aaagaagtat cgatcattca ccgccgcgac aagttccgag cgcacgagca cagtgtggaa 3070441 aaccttcatg cgtcgaaggt taatgtcctg acaccattcg tccctgcgga gctgatcggc 3070501 gaagacaaaa tcgaacagct agtgcttgaa gaagtgaaag gcgaccgcaa agagatttta 3070561 gaaattgatg acttaatcgt caactacggt ttcgtttcat ctcttggacc gatcaaaaac 3070621 tggggcctgg acatcgagaa aaattccatt gtcgtgaaat caacaatgga aacaaatatc 3070681 gaaggcttct ttgcagcagg tgacatttgt acatacgaag gaaaagtcaa cctgattgcc 3070741 agcggcttcg gcgaggcacc gacagcagtg aacaacgcca aggcttacat ggacccgaaa 3070801 gcccgcgtac agcctcttca ctcaacaagt ctttttgaaa ataaataata aaaaaaggag 3070861 cttgtgtctg cgacacagct ccttttttat ttgaagatat ttatataatt caatgcagtt 3070921 cctacaacca gcgcaatcac aagggctgcg actacccaga tcattgccat aataatgcgg 3070981 tcctgaatct tttgggactt cggtgttttt tcttcgtttt gggccatctt attcgctcct 3071041 ttcccatgtc catgccataa agaaagcctg gtgctgaacg accaagcttt gctgaacgta 3071101 tatcattcgc gttttgatcc gctctctaag accattcgtt aaaactatga tacctaaact 3071161 caccctgcat gacaagcttc ggcacttgca ccacacctgc cagcaaatca taatgtttga 3071221 catcctaaat aaaacagagt acattatata aggcgaacat ttcatatatt atacttttaa 3071281 atattcgttt ttaggagtga aaaccatgga aaacgtattt gattacgaag atattcagct 3071341 aattcctgca aaatgcattg tgaatagccg ttcagaatgt gatacatccg tacgtttagg 3071401 cggacataca tttaaattgc ccgtcgtccc tgccaatatg cagacgatta tagatgaaaa 3071461 actagcgatt tcattagccg aaaatggcta cttttatgtg atgcaccgat ttgagcctga 3071521 gacacgaatt gattttatta aagatatgaa cgcacgcggg ttattctctt ctatcagcgt 3071581 gggcgtcaaa gatgaggagt atgaatttgt ccgccagctg gcagaagaaa atctgactcc 3071641 tgaatacgtg acaattgaca ttgctcacgg gcactcaaat gctgtcattg aaatgatcca 3071701 gcaccttaaa aaacatttgc cggacagctt tgttattgct ggcaatgtcg gaacgccgga 3071761 agcggtcaga gagcttgaaa atgcgggagc ggatgccact aaagtcggca tcggaccggg 3071821 aaaagtatgt attacgaaaa tcaaaacagg cttcggcaca ggcggctggc aattagcagc 3071881 gctgcgctgg tgtgccaagg ctgccagcaa accgattatc gcggatggcg gcatccgcac 3071941 ccatggcgac atcgcaaaat caatccgatt cggcgcaacg atggtcatga tcggttcact 3072001 atttgccgga cacgaagaat cgccaggcca aacgatcgaa aaagacggaa agctttacaa 3072061 ggagtacttc ggctcagcct ctgaattcca aaaaggcgaa aagaaaaatg tcgaaggcaa 3072121 aaaaatgcac gtggcgcata aaggctcaat caaggataca ctgattgaaa tggagcagga 3072181 tcttcaatct tctatttctt atgcaggcgg aacaaagctt aacgccatcc gcaatgtgga 3072241 ttatgtgatt gtgaagaatt ccatttttaa tggggataaa tattaatcat aaaaaaacgc 3072301 caagtcagcg gttctccgct tgagttggcg ttttctgcta cttcttcagc aaagtaagct 3072361 tatatttgct ttttgagttt atcttccatc agttctgcca tttgttttgc atttggattt 3072421 tcttcatttt gcaactgttc aatgacgttc atataatccg tttcatttcg gttctggctt 3072481 aatttatatg ccgcttgaat gtcttccacc ttaatcttaa atccaacaat acctttcaat 3072541 tcactttcta agagttttgg agaaagctta tcccataaca caggattgtc acgatgtttt 3072601 tcgtatttct ccaacatgat tgttaattct tctgctaatt catctttctc taacatactt 3072661 gcttttccat acatgtggac agcctgataa ttccacgtcg gaacattttc gcgcgaatac 3072721 caggaagaag aaatataagc gtgcggtccc tgaaacatca caagcacatc ttcacaggct 3072781 tcaaacgttc tccactgagg atttccataa gcgaaatgcc ccgtaatata gtaatgatcg 3072841 tcttttttat tgaatcctaa cggcaaatgt gtggcaattg gttttccttg ttctgttgtg 3072901 acaaccgtac caaaggagtt ttcttgtaca aaattccaaa tttcttcagc atttgtgact 3072961 ttaaaatatt ttggaatata catcatcatc cacccttcga aaaatattat atgagtgttt 3073021 tagccatgat taaatccgtt tgttcttcat cacccatata aaatgagtgg gcgccggtct 3073081 gaacaaaccc cattttctta taaaaggcaa tggcattttc atttttttcc cacacaccta 3073141 gccaaatgtt ctttttatta cgttccagcg caatttctat cgctttattc agcagatgtt 3073201 tgccaagccc atgtttttga aagctgttct ttatataaat tctctcgatt tcaagtgatt 3073261 cagcacccat ttcttcagac tgagcatcat cgatattgac ctttacatat ccagcgattt 3073321 catgatcaaa gtaaataaaa aagaattgcg aagacatatt agataactct ttttccagct 3073381 gctcagtgtt aaatgcgctt tctaaatagg ctttcatatt ttcaggtgag ttctgttctt 3073441 taaaagtgtc attgaatgtt tcaatactca attgttgaag tgtttgtaaa tcttcccggc 3073501 tgcatttttt catttttaca ctcattgttc ggattcagcc cctttattta aaattcaatt 3073561 gtcttgtgtc ccttttatat atttaaacac ggaacacata ctgaccttgt taccattcca 3073621 aaaatcttct tcatcaccaa ctccctatcg tgattttgtt gtaaatgcaa taaaatatac 3073681 tccgcattaa atatatcgta actttgctgt atttacaaca aaaatcaaac aacaaagcag 3073741 cgtttctctt gccgaagttc ccggaactct ctgcatcatt tccccataat aaaaacgcct 3073801 cccttaacga tgatttatcg ctaagaaaag cgtcagtaat agttgctatc cgtttttagt 3073861 gcttagcact cttcaggctt gcctgcattc gttgctgttc tgaacgaaga accgcagccg 3073921 catgaagcga tggcgtttgg attgtcgatg gtgaagccgc cgccgagcat ggattgttta 3073981 taatcaatca cggtgccgtt catgatgtca aggctttctt tgtcaactag aacagtgatg 3074041 ccgtgctgat caaacacact gtctgattca ctcttttcat gctcaaagcc catgccgtaa 3074101 gaaagtccgc tgcagccgcc gcctttgacg cctacacgca gaaacgcgtt ttcttcttca 3074161 tgctctttca tcatatcttt tatatgcaaa gctgctgctt ctgtaattgt taccgggttg 3074221 ctcatcatta tgaacctcct tttaaaaacc ggttgctgtc ttttattata aacatgatcg 3074281 ttccaattct caaacaaggt gttttacaag aaatagacac cctcacaaac ggtttcagcc 3074341 ggccctgtca tcattacatg gccgttatct ttccagttta tcaccaaatc cccgcctgct 3074401 aaatgcaccg tgatgtcttg atttcgcttt gatacgccgt ttaatacaga tgcgactgcc 3074461 gctgcacatg ctcctgtccc gcatgcctga gtaatccctg atccccgttc ccagacgcgg 3074521 aaatgcaatt cttgttcatt cacggtttca acgaattcca cattgatgcc ttccggaaat 3074581 ctcggatctt tctcaatcac cggccccagt gtcgttaagg gtgcctgttc aatgtctgcg 3074641 atcggaaaaa cgatatgcgg atttcccatt gaaacggcag tgcctgttag ttctacttca 3074701 ccaaatgcca tcgtttcatt gattgtgtgc tcttccccgc cgtcaagcat aggaagctcg 3074761 gattttgtca agcgcggttc gcccatatcg acagtgacca cattcacttt tccgttttcg 3074821 acttgaacct ccgctttcac aagcccggag agagtttcaa tcagaaaaga tgtttcctca 3074881 accagcttat gctcatatgc gtattttgcg acgcagcgca ggccgttgcc gcagtttttc 3074941 ccttcagacc cgtcattatt aaaaatccgc attttaacag gcgcttggtc tgatgggcat 3075001 atcaggatca ttccgtcgga tccgatccct gtataaacag aagaaacctg aattgcaatc 3075061 tctgacagtt tttcttctgg aagctgttct tcaaattgat tcacataaat ataactgttt 3075121 cccaggccgt gcattttggt aaatcgaaat gagttcatag gtgcctccaa ctttttttct 3075181 ttttcttagt ataaaagcta ttataagcgg acacaataca attatccccc gtttttcata 3075241 cataaaagct ccttgcactg acgcaaggag cttttatcgt ttatataaac atgccggcaa 3075301 tggctgcgct gagcagattg gctaatgttc ctgcaagaac agccttcagg ccgagacgtg 3075361 cgatatctga acggcggctg ggcgctaaac cgccaagcgt accaagcata atcgcaattg 3075421 atgaaaaatt ggcgaatccg cataacgcga aactgataat ggtagcagtt ttcttagaaa 3075481 actcgccgat gtgcgaaccg aagttagaat aagcgacaaa ctcattcagc accaatttct 3075541 ggccgatata gcttcccgcc tgcaatgctt catgccaagg cacgccaatc aaaaaggcga 3075601 taggagaaaa cacatagccg agaatggatt ctaatgttac gccttttaaa ccgaacaagc 3075661 cgaaagcccc gccgagaata ccgtttacta cagcgattaa cgcaacaaac gcaagcagca 3075721 tcgccccaac atttaacgca atttgcagtc ctgttgacgc tccctttgca gctgcgtcaa 3075781 tgacattggc tgcgccttcg ccttcatcca ttttgaaatc gctttttacg gtttgcgttt 3075841 tttccgtttc gggtataatc aatttaccaa agactagtcc agctggagca gccataaagc 3075901 tggccgccag caagtactca atcggaatac cgagaagcgc gtacccaaac aaggtagatc 3075961 ccgcaactgc cgatagaccg ctcgtcataa tcgtaaacaa ctcagagcgc gtcagcccgg 3076021 caatcagggg tttgatcact aacggagatt ctgattgtcc tacaaaaata ttggcagcag 3076081 ccgccagaga ttccgttttg cttgttccaa ggagcttcga caatccgccg ccaatgacac 3076141 ggaaaacgag ctgcatgatt ttcaaatgat ataaaactgc aatcagtgct gagaagaaaa 3076201 tgataacggg cagtacactt aatgcaaatg ccggactgtc tccgaccttt agaagcggtc 3076261 caaaaataaa actgatgcct tcattcgcat agtcaatcag aagctgtaca cggcttgaaa 3076321 accataaaaa aacagcgcgt cccgcttccc atttcaacac gatgtatcca aacgccacct 3076381 gtgtgcataa accaacgatg acggttctta tcttaatatt gcttttcttt tctgaaaata 3076441 aaaacgcgat agcaatgatc gcaactgcgc ccagcagccc ccacagaaca ttcatgaata 3076501 ctcgtacacc tcttaaattt tatttaaaaa aatatctttt atacgataac aataatattt 3076561 tttgatgtct acacattttt ttagttcttt tgtacggcaa aataaaaaag ggcctgtcca 3076621 ggcccttttc tttaaaacat tggattttct tcaataaagg tatatatatt ctcaacaagc 3076681 tcagcaggcg tttcacccat gacgacttct ccgtttacca gagcgaaaag cgattccata 3076741 catgtcccgc agtagcttaa gcagccatat tcaaggacat caaggttggg atccttctcc 3076801 aaaatcgccc gggcttcctg agagccgtga gccagattgc tgacacaaaa ttcaatcatt 3076861 ggattcatgc ggtttcacct cacatatgtc cattatcgcg aatttttcac tattcgtcaa 3076921 agacaacgga tgattcaaaa tttattatcg taacatatta tttctcaaat aacgttttac 3076981 taatttgtgt tttcaggcta aattgtaggt tattttgaaa ctattattgt gattttagat 3077041 caaattcgat ataattctag atgttatttt acatagttcg tattttcttc aatgtatcta 3077101 tcatactctt cggattaaag gggaattcaa atgaaaaaat tggtcttgat cggcggaggt 3077161 tacgggaaca tgcgcgttct tcatcgctta ttgccaaacc agctgcctga tgatgtttca 3077221 atcacgttaa ttgacagaaa tccttatcac tgcttgaaaa cagaatatta tgcccttgcc 3077281 gcaggcacaa tttctgacca tcatatcaga gtgtcattcc cagagcaccc tcgcctggat 3077341 gtccaatacg gtgatatcac atcaattgat attgtacaaa aacaagtgct gttccaagat 3077401 cgtgaaccga tttcttacga tgacgccata atcgggctcg gctgtgagga taaatatcac 3077461 aacgtgccgg gagcgcctga attcacctac agtattcaaa ccatcgatca gtcccgcgaa 3077521 acctaccaaa agctgaataa tctgagcgct aatgccaccg tcgccattgt cggagcgggc 3077581 ttaagcggcg ttgagcttgc aagtgaattg agagaaagcc gtgatgacct gaacattatt 3077641 ttgttcgacc gcggtaatct cattttatca agctttcccg agcgtttaag caaatatgtg 3077701 caaaaatggt tcgaagagca cggtgtccgc attattaaca gggcaaatat cacaaaagta 3077761 gaagaaggcg ttgtgtataa ccacgatgat ccgatttctg cagacgccat cgtgtggaca 3077821 gccggcatcc agccaaacaa agtcgtcaga gacttagatg tggagaagga cgcacaaggg 3077881 cgtattgtat taacgcctca tcataatctt ccaggtgatg aacatctgta cgttgtcggc 3077941 gattgcgcca gtcttcctca tgcaccgagc gcccagctgg cagaggctca agcagagcag 3078001 attgtccaaa tcttgcaaaa acgctggaat ggagaagccc tgcctgaatc aatgccgcag 3078061 tttaagctga aaggcgtcct cggttcactc ggaaaaaaag ccggcttcgg gcttgttgct 3078121 gaccgtccgc tgatcggccg tgttccgcgt atgctgaaat ccggcttgct gtggatgtat 3078181 aaacaccata acggttaatg atagagaaga accgctgatc aagtcagcgg ttttctgtat 3078241 acccatgctt ctccatttcc tcataaacgt cttttaattt tggattgcct tcaccgacaa 3078301 ttttgtcttc tacaagcaca agcggataaa aatactcgtc atttctgatt ttttccgcaa 3078361 gctctttcgc atgttcattg tcaggcggct catgaatatc gatgtactgc atctcaaaag 3078421 gctgatttgg atattttctt ttcagcgcag cctcaagcca ctcgtatgta tccttggctg 3078481 tcggcatatt tacacagctc gcacaaacgt tttctgcccc gtacacgctt agcatgactg 3078541 gtttcatcac ttgtagacgc ccccttctcc tatgtaagtc ctttctttta agtatacaga 3078601 gcctaagggc gtttttatag aaaaaaaccg tttttgtgtt gaagtctgaa tgtgctataa 3078661 tagggaaagc aactttgcaa accaaacaat agatttttat tgttacactg aatataatgg 3078721 ttttatgacg acgaaaggag cgaatgtcat gactgaagtt gaaatgaaag aacaggtgca 3078781 ggaagtactg gacaaacttc gtccgttttt acttcgtgac ggcggtgact gtgagcttgt 3078841 agacgtagat gaaggtatcg ttaagcttcg tcttctaggc gcatgcggca gctgcccaag 3078901 ttcaacaatt acgttgaaag ccggaattga gcgcgctctt cttgaagaag tgccgggtgt 3078961 cgttgaagta gaacaagtct tttaataaag cagccaggct gatatttgat cagcctggct 3079021 tttttattag agatgttgat caaaccatga gctgatataa ttcaggcgct tgatccgctg 3079081 tcttgggtgt ccggtgcgtg ataaattgtg cgatgcattc ggaaaacgga caagcttggt 3079141 ttccttgccc atttttttca gagcgataaa cagctgctcc gcctgctcga tcgggcatcg 3079201 gtcatcccgc tcgccatgca gtatcaaaag cggtgtctcc acgtttgctg cgtattttaa 3079261 aggagaccgg tcccagagct tttctgtgtc ctcaaacatg tcatgctcaa gctgccagtc 3079321 tgtaaagaaa tagccgatat cactgacgcc gtgaaagctg atccaatttg atatcgagcg 3079381 ctgggtaacg gcagctttaa agcggttcgt ctgcccgacg atccagttgg tcataaaacc 3079441 tccgtagctt ccgcccgtga caccgagccg cttaggatca atatgcggat ctcgtttgat 3079501 agcctcatcc acagcctgca tcacatcgtc ataatccttt cccccataat ctcctctgac 3079561 cgcattcaca aattcctgcc cgtagccgtg gcttcctctc ggattgatat aaacgaccgc 3079621 gtatcctttc gccgccagca cctgaaactc atgaaaatat gtatgtccgt acatcatatg 3079681 cggaccgccg tgtatgttaa gaataagtgg atatgttgtc tcaccttcca tttgtgcagg 3079741 cctcatcagc cagccgttca ccatcacgcc gtcttctgta gcatattgaa tctcttcagg 3079801 tattgatatc gtatgctccc tgacaaactt gtcattcgcg ccagtcagct gtttctcttc 3079861 ctgtccaagc gggatactgt aaagctcact cggtctgtcc ggctttgtca cactggcaat 3079921 aaagtgctgt tcatcaggtg aaagagaaaa gctattgatg tactcttttt ccagacgaat 3079981 cggatacaca aggccttcaa tcgaaatata atagatgccc gtactgcctt gatctgtgcc 3080041 gatgacataa aacccttggc tgtcctttgt ccaaatcggg cgctgttcag caccaccgat 3080101 caatgaatct ccaatcagcg catccgctaa atgaacgtcc agcatctcag taagacatgt 3080161 gaggcggcct tgttcgatat catagagcca cgcctttgag agcgtagcat tcttatattc 3080221 cttttcattt ccaagcaaag caagatacct tccgtctggt gaaaatgagc ttgatccgaa 3080281 tgagccgcga tgaggtgtaa cctgcttaag atctccagac tccagtgaca ttatgtaaac 3080341 atcatgcggc ttgctggcat catctgtttc agttaaatta gctgagaaaa caagccattt 3080401 gccgtcagga gaaaaagcag gatcaccatg atcagctttg tgacttgtca gctctttcat 3080461 ctcacccgac tttacgctga caagcacaag ctgggcatac gcacctctcg tcagcccttt 3080521 gccgtcccgt ttgtaggaga ggccttgcac ttcaacaggt tcatagctgt cctgctctgt 3080581 tttttctcgg tcatcaatgc tttccccctc tcccaaactg acagtgacca gaatcgattc 3080641 accgtccggg gaccatagcg gctttgacac gccatatggg atatcagtca gttttcttgc 3080701 ttctccgcct tcagtgctca tgatataaag ctgtgccgca tcgccttctc gatcagaaat 3080761 aaaggcaagc gtgcgcccgt ccggagacca tcttgggtcg gtgcttcgct tttctccatg 3080821 tgtccaagga acagatcctc ccgttttcgt ttcatagatc catatatttg atgtatacga 3080881 atctttctct tgatttactt gtgattttac atatgcggca cgggtaccgt ctggggcgta 3080941 ttgaggatcg gtcacagaga caatcgctgt gatgtcgtct gcggttatca gctttttcat 3081001 attcatctcc tcctttttac atgtatttcg tttttctaaa taaaaactcc tttatctcca 3081061 gcaaaaaaaa gcgccctccg ctgacgctga ggaacgcttg gcatgatcta tacacttttt 3081121 acttgatata aaggatttcg ctctattata cttccctctt tcggaacggt caaagcgtct 3081181 acttcacaat gagggaaatg aagcgcgagc tgttctttta gctcttctcc ctttcctttt 3081241 tcggtcatga cgagaatcgt tgggcctgct ccgctgagag ccgttccata tgcgcccttc 3081301 atctcggcga cgtgctctac ttttgacagc tcaggcacaa gcatcgcccg gtacggctga 3081361 tggaacatat ccttcttcat gattttcccg acaagcggcc aatccttgga catgatcgca 3081421 gcaatgagga tattgctgac agcacttgct tttacggcat cggcatatgg aaactccttc 3081481 ggaagcacgt ctctcgcgtc tcttgtcagc acttcataaa aaggaatgac aacgactacg 3081541 tcaatgtcag cattcgggac gcggatcatt tgggtctcgt catcctcatg caggccgatc 3081601 acaagtccgc cgacgagaga agcgccagca ttgtccgggt gtccttcttc tagactcgct 3081661 aaatgcagct tgtccgcttc agacagcttt aagccgcata attcatcagc cagttcaatg 3081721 gccgctacaa tcgctgcggc gctgctgcca aggccgcgtg caagcgggat gtcgctccac 3081781 accttcacat ggacaggagg catttctttt ccgtacaaat ctgcggtccg tttagccact 3081841 tggtagatca ggttatctgt acccgccgga attccggcga ctgtttctgt ttcagcctca 3081901 aaagaccatt tgtcgctttc aaagacggtc agcttcaaat atctgctgag cgccattccg 3081961 actgaatcaa agccggggcc taggttagct gtgcttccgg gaacagtgac agagaacagc 3082021 atgtcggctt cgttcataca cgggccgctc cttttacata ttcaaggatg ctgtcttcat 3082081 cagtcggcaa tgtgacaggc ttgatttctg aaatgtcgac cgctgtgttc ggatctttca 3082141 gtccgtttcc tgttaacaca gctacgacct tgctgccttt cggaatttct ccggatttca 3082201 cctgtttcag cactcctgcg atagacgcgc aagaacctgg ttctgcaaac acgccttcta 3082261 cacgggcgat cagctgatat gcgtgaagga tttcatcatc agtgacttcg tcaattttcc 3082321 cattggattc ctcggctgcc tttacagctt tgtcccagct tgccgggttt ccgatacgaa 3082381 tggctgtcgc tattgtttcc ggattttcaa tcacttcatt gcgcacgatt gccgccgcac 3082441 cctcagcttc aaagccgcgc attttcggaa ggcctgtgcc gtttttctca tgatattcct 3082501 tgaagccctt ccagtacgca gtgatgtttc cagcatttcc gaccgggatc gctaaaacat 3082561 caggcgcttc ccccagctgt tcgcacactt cgaaggcagc agttttttgg ccttcaatgc 3082621 ggtaagggtt gactgagttg acaagggcaa tcggtgattt ctcacagatg gaacggacaa 3082681 ttttaagcgc atcgtcaaag tttccgtcaa ttgcgataat ctcggctccg tacatgacag 3082741 cttgagcgag ttttccaaat gcaatttttc cgttcgggat gatgacaatg catttcatgt 3082801 tagcacgggc tgcatatgct gccgcagcag cggaagtgtt acctgttgac gcgcacataa 3082861 tcgtgtcatt gccttcttct tttgcctttg ccacagccat aaccattccg cgatctttaa 3082921 atgatcccgt aggattgacg ccttccgttt tgacatgaag ctcaattccg agctgctcag 3082981 acagcttcgg caggtgaata agaggtgtgt ttccttcatg taaagttagc gccggtgttt 3083041 gatctgttac aggtaaaaat tctttatatt gatggataag tcctttccac attagctcca 3083101 accgttccct tctacacgat atgtgctttt gacttcttga acgacttcca aatcatttag 3083161 gttttgcagg atatcactga aatcagcttc tgatgtatga tgtgtgacaa ttacgatttc 3083221 agctaactca tcatggcctt taattggcag ctgaaggatt ttttcaaagc tcacgccccg 3083281 ctctgagaac acagatgtaa ttttcgagaa tgaaccaacc tcatctttta catgaattct 3083341 taaaaactgc tgtgcataaa tgtcagacgg cgatttcatg tttttctcat attgcggtcc 3083401 gacaaagctg ttgccggtta cacctaggcg catatttttc atgacagcga cgaggtcaga 3083461 aacaacggat gtcgctgtcg gcatgcttcc ggctcccggc ccgtagaaca tcgtctcacc 3083521 gacagcctcg ccgtatacat aaacagcgtt aaactcatta tgaacagcag aaagcggatg 3083581 atggtcagga agcagtgtcg gctgtacgct gacctcgatt ttgctgccgt cacgctgagc 3083641 aatcccgatc agcttcattg tatagccgag gcgtttgctg aagctgatgt cctcgtctgt 3083701 aatttgggag atccccttta ctttgacgtc ttccagatcc acgttcatcg agaagccgag 3083761 gcgcgccaat atcgccattt tccgtgcggc gtcaagccct tccacgtcag aagtcggatc 3083821 agcttcggca aaaccgagat cctgcgcttc cttgagcact tcctcgtatg ggcttttctc 3083881 tttgatcatt ttggttaaga taaagtttgt tgtgccgttc acaattccca tcatttttgt 3083941 aattcgatct gatgagaggc cttcctctaa cgtgcgcaga atcggaatcc cgccggcaac 3084001 actggcttca aagtagatat cgcatccatt ttccttcgct tcggcaagca gctcggagcc 3084061 gtacacagcc attaagtcct tgtttgctgt gacaacatgc tttttcgatc tcagcgcgtc 3084121 gaccaaatat tgttttgtct gttcaacgcc gccgatcacc tcgatgacga catcaacatc 3084181 tggatcatca atgacatcat acacttctgt cgtgagcact tccttcggca aatctacttc 3084241 tctctttttc tctaaatctt ttacaagcac tttttttatc gtaaccggac agccgacctg 3084301 atgcataagc ttatcctgat ggtcttgaat aattttaacg acaccgcttc cgacggtacc 3084361 taaacctaaa agccctacac gaatcgcttt caaaaaaact ccacctttct tttgattgtc 3084421 ctcttggaaa agacaattgt taactcaaca cagacatata agttacaaac attatataag 3084481 cccgctcctg ttttgacaag acatcattag gctgaatttt gcgaatgtaa acgcttaacg 3084541 cattgatatg acaagattct ttattttcta attatttttg tcagattttc tcctcacctt 3084601 gagctgcctt tgccgagcca gctgacgcgt ggaacaaaca gcttctgcgc ccgcatattc 3084661 atgaattcct gcgctgtatt gagaaattgt tcataacgcc cacagtcatt aagaatgaag 3084721 tcaagctgtt cttcaaaata atgcttttct gattctgatg acatgtaata gctttctacg 3084781 atttcaaaat aatgaagcgg gaaaagcaga cggctgtata aaaggcgttt cgaaaatgaa 3084841 gacagcggtg tgacttgctc gtattcctgt aaaaagagaa agccctgctg attaaaatct 3084901 tgtctgtgat gcaaaaacgt atgcctcata tattcagcca aatcacggga agcgtggtca 3084961 aacacccaat ccgccggaat cctgatcaat gattccggtg accatgtatg cctttccatc 3085021 cgctgatggc atatcgttcc tgaatcagcg gcttggggct tgtcatccag ctcagtgtcc 3085081 actaaatatt gtatcgcgtt ttctgacagt cctaaataat atggaaatga ttcgatcatt 3085141 tttttatcga atggctcatg cggaggggtc tgaacctttc tctgccaaaa tgcttccagc 3085201 tgatcaattc gttttcccca cagatccttc cactggccga ttcttccggc cgccttcacc 3085261 tcatatggat atcctcggcc ttttcggtga aattccgcaa gctccgctcc aatggagaac 3085321 gccctgtttg aataaggggg ggccgccttc agcagagcgt acgtttttcc ctcatgttca 3085381 aatgtcagtt caccttcttt tgtaaagata aaaaccgaaa cgtatgggtc actttgttct 3085441 tgtaaatact gactcatgta ataaagctcc gccagctctg tttctgagaa ttgggaaacg 3085501 gggacaatca gaaagtatga attaggcgtc tgaaagcatt gatatgtgtg ctggtacatg 3085561 gaaagctgcc tgatgtgaat gccgtatttt tcttttattg tacctttcac catgatcacc 3085621 tgcctgttga attagggctc atcacatcgt agtcatacac agccggaatt atgaatacat 3085681 attttaatcc gaagaaggcg caagaaaaag tcgtaaactt ctcaagcatt ttgtataaac 3085741 tagtaaaaaa gattgggtga agctgatgtc agaaaacgaa caattcagtc agatggaagc 3085801 taaagcaaga gcacggatga aggagcgcgg cgttgaggta tcagacattg ccgagcttgt 3085861 cttttttctg cagaaaaaat atcatccgga tttaaccatt gatgaatgca cgctgaacgt 3085921 caatcgtgtt ctcgcaaaac gcgaggtgca aaacgcgatt ttaacgggca ttgaattgga 3085981 tgttcttgct gagcagaaaa aattgtctga accgctgcaa acgatgctgg aaatagatga 3086041 aagcctatat ggagtagatg aagttctggc attttccatt gtgaacattt acggatcgat 3086101 cgggtttacg aactacggtt acatcgacaa agaaaaaccc ggaatcctta aacgattgaa 3086161 tgataaatca accggtgaat gccatacctt tttagatgac atcgtcggag cgatttccgc 3086221 cgcggcttca agcagacttg ctcaccgcgc gcggcataca gaataagggc acccttttag 3086281 ggcgcccttt tttcaaatgt atggaatcca ttcagtcaga gagtcaatgg cgtgagtcgg 3086341 tttttccata tcgtctgtca tatgttctct tttcgttacg cctgtgtgaa cgagcagcgt 3086401 atccataccc gcgttaatgc cggccataat atcagtggcg tagttgtcgc cgaccatgag 3086461 tgtttcagac acatctgtgc cgagaacgcg catcgcctgc tccataataa ttgattccgg 3086521 cttgccgata aatacaggct gtacacctgt agatacggtt aacaccgatg tcagtgagcc 3086581 gtttcccggc aggagccctc tttcagtcgg aatcgcaata tctccgttag tggaaataaa 3086641 gcgggcgcca tttctgattg ccaggcagcc aacagcaaat ttttcgtatg taatggaacg 3086701 gtcgatgcca acaacgacaa aatccgcgtt ttctccgcca aatgtcaggc cgttttcttc 3086761 aatcgcctgg cggattcctt cctccccaat cacatacaca gacgcgtctt ttttctgctg 3086821 tgcaatgtgc tgggcagttg ccatgctggt cgtgaagacc tgctcttctg ttgccggaat 3086881 atcaaaagac acgagcttgt ccgctacctg cttcggtgtg cgcgaagagt tgtttgtcac 3086941 gaaaagataa ggaacgccgc gatctttcag cgttctgaca aattcacacg cctcctcgat 3087001 tttttccgtg ccattgtaca tcgttccgtc taaatcaatt aaataccctt tatatgtttt 3087061 catatccaac actcctgtgg ctttccagtt gttatttaaa cgcggaaaca ggtcctagct 3087121 ctgtttccaa atagcttctg atccgtttcg ggaagtcctg aagagctgtt tgatgcgcct 3087181 tgatcagcct gtaaagctcg ccgctgtcag cgagcagata ctgttgaacc aacgttttgc 3087241 ggtaggcgat caattttttg agctcatcac cctctttttc cgtgacaact ttctcatcaa 3087301 caagtatatc cataatgtcg tcatagctgc ccgggtcccg cataataaag ccgtcaatca 3087361 tgtcattgcc tgtatccaaa atgcattcga ttaacagatg gcctatacgc tgaagtgcca 3087421 attccccgat ttcagactgc cagtctgttt gtgagtcaaa tagcgccagc tggtgctcga 3087481 agaaccctag tgttttttcg attttgcttc tgtcaacaaa atacatgaca gcatcccctt 3087541 tgtgtatatt tattttctga tccgtttcaa gacaaaatac gcacagccga aattgcagta 3087601 ttcgtaaata tattcatcta atgtgctgat tttcgtttcg aaggttgcct tttgattctg 3087661 gtcgtcaaag aagcccttga gccttaactg accgtatccc cagtctccca caatataatc 3087721 gtatttattt aatatatcgg agtagcgggc tttaaaagcc tcttcgttga agccgtcttt 3087781 gaaattgtgc accaattcaa attcggcatt ttgaataaga atcatgatct cacctctttt 3087841 ttcactcatt cctatcataa ttcattgccc cgtccccatc aattgctaaa gaataaatca 3087901 tgcgatttgg ctaccctaca catgaggagg gattgataaa tgaaacgaac cgctgtcagc 3087961 ctctgcctgc tgaccggact attatccggg tgcggaggcg caggattgga taatgcccaa 3088021 aatgtccgga atcagacgca gaatcaaacc aaacccattc atgtgtcgga ccgcaacgag 3088081 gcttttaaca ggcataatga gaacgaacaa tttggctatg tccgctatca aaaagaacaa 3088141 tttgacggag aacagcagaa aacgccggtg atgaaccggg aagaaaccgc tcacatgata 3088201 tcaagtttaa cggttcagct cccccatatt caagatgctg cgacattggt gactgaccga 3088261 gaagcgcttg tcgtatacaa aaccgattct aaaaaccggg agctgaccgc cgatcaggtg 3088321 aaaaaaacag cggcttctgt gataccgcga tactatcacg tgtatatttc cgataatcca 3088381 aaccatatgc aatccgtcga aaattacagc aatctcggct ctggttcaag ggatattaga 3088441 gagatcatgt cggggacgat tcaagaaatg aaaacctccc cgcaaggaag ccctgtctca 3088501 gagaatgaaa atgccaatgg agaaacgcgt caggacatga aaatcgatag gaatgacaaa 3088561 aacgccagat gatctggcgt tttggcatta tgcttgtgct tgacgctttt tagatgcttc 3088621 gtttacttgt tcatccgcat ggtaagagga acggacaagc ggaccggctt cacaatggct 3088681 gaagcctttt tgcatcgcga tttcttttaa ttctgcaaat tcatcaggat ggtagtattt 3088741 ttggactttc aagtgtttct tcgtcggctg cagatattgg ccgattgcca taatatccac 3088801 gttgttcgcc aagaggtcgt ccattacttc aataatctct tcttttgttt cgccgagtcc 3088861 gatcatgata cttgattttg tcggaatgtc aggctgcatt tccttcgcac ggcgcaaaaa 3088921 ttccaatgaa cggtcgtacg tcgcacgcgc gcggactctt ggcgtcaggc ggcgaaccgt 3088981 ttcgatattg tgattcagga tgtctgggcg tgtatccatc aaggttttta ggttatcgta 3089041 gtttccgccc atatcagacg gcagcacctc aattgttgtg aacgggcttt ttctgcggat 3089101 cgcacggaca gtttccgcga aaatgcctgc cccgccatct ttctgatcgt cacgcgcaac 3089161 agccgtaatg accgcgtgtt tcaaattcat aagcgcgact gaatccgcta cgcgttccgg 3089221 ctcttgcaga tcaagctcag ttggaaggcc tgttttgaca gcacagaaac ggcatgctct 3089281 tgtacaaaca gaacctaaaa tcataaatgt cgctgtacgt ctgaccgccc agcattcatg 3089341 aatattcgga cactttgctt cttcgcatac ggtatgcagg ttgttttccc gcatgagttt 3089401 tttgagccct gtatagtttt catttgtatt taatttaatt ttaagccatt cgggctttct 3089461 gaggtgttcg tctttctttg ccaattccca tcatctccaa tatccaatat actcaatttc 3089521 tgacacgaaa cattctgaaa acgagaaagg tgcaggtttt agttctgcaa caaaaataat 3089581 gtttttctaa ctaaagaaag tcttttcttt agacacttta acataggaaa aatttctcga 3089641 caagggaaga tgattactga catttttaag ccgggttgcc gcaaactatg tgtattcaat 3089701 atgaaaggag attattttgt gaaagttttg ttatccgctc ttcttctcct tttgtttgca 3089761 tttgagcctt ctgcgtctgg aaaaaaactt tcagatccag tgctgtcgaa acggatggaa 3089821 ttatatcata aaatcgaagc tgtgacgcag atcccttggt atgcgctcgc cgctgttgat 3089881 caatacgaag aaaacgtgcg gagcaaccgg aaagatctgc ctgaaaaggc gggaatcatc 3089941 agcatctata tacccgatga tatctggagc gggcctgaaa acccgaatcc gaaagacgat 3090001 gcgccgttaa gcattaaagt gtttgacgga atcggaatgg atggcgatgg agacgggaaa 3090061 gccgaggtca gcaacgatga agatatcttg tatacgttca gccaatactt actgtcgtat 3090121 ggcacagatg aagacaacat ccggatcggg ctttggaatt attaccggcg tgatcagaca 3090181 gtggggatta tatctgaatt catgaagctg tttaaagcct acggccatat tgatctgggc 3090241 gagcatgcat tcccgcttcc gatcagaacc gattacagct accgaagcac gtggggagat 3090301 gcccgcggct tcggtggaag gcggattcat gaaggtacgg atatctttgc ccattacggc 3090361 cttcctgtca aatccacatg ttacggcgta gttgaaatga agggctggaa ccgcttcgga 3090421 ggatggagaa tcggcatcag ggacattaac aatacgtatc attattttgc ccatctcaat 3090481 gggtttgcca aagggattaa aacaggacaa atcgttgagc ctggccaagt gatcggatca 3090541 gtcggcagct ccggatacgg cccgccggga accgccggga agttcccgcc gcatctgcac 3090601 tatggcatgt acaaagataa cggaagaacc gaatggtcat ttgatccata cccgcatttg 3090661 agggcgtggg agcgatatga ataccaaaaa aagaagtaac aaaaagccgc ctcttcaaca 3090721 ggcggcttat ttgctgcttt tttctttttt tgaatcggca ccgttttctt tgctgctcgg 3090781 aagctggaca gaaggcgtga cacccgagcc gccgcttcca ttataaaact gcggcacttc 3090841 gccctgcact gctttaatcg atacaggaac attatttgtg acgacagcgg ttttgctggc 3090901 aaatggaatg atgaccttca ctttaatttc gacaaagatg ctgatatcaa taagtgcgtt 3090961 atttatgcca tacggcttga ttttggtttt gacatctgta aaagcgtcac cgattaaatt 3091021 gaaccggacc gggattttcg gcccgaggtt tccaagaagg ctgttgccgg ttacctgtcc 3091081 cagcggaatg ttgatcataa tgttttcact ggcgccgctg tgtccggtat gggtttccat 3091141 ctctttcaaa tgagcctgaa gctgctttgt cacttttgtt ttcacactgt ttacaacctg 3091201 tgtattaaaa tcgattgtcg ttaagtttcc gttttcatca gaattcattt gaaacatatc 3091261 tttcatattt tcactgtcag acatatagtc ctcaatcgaa tcctggatca cctctgtcgc 3091321 tatacgcttc gtttccatct cgccgatgtc cattaaaaca ggtttgatcg agccattgat 3091381 catccaaagg ctgaccgttg ttgacaggat aaaaaagaca acggacagga gcatcacgta 3091441 acggaaaggc aaaggtcctc tcttgcgaaa agggccgcga tatcttggca agaaaatccc 3091501 cccttacata tcacaatgta tgcttgtaag aggggacata gtaatagccg gggccaattt 3091561 attttatttc atcattttta aaagcgcttc tctgccgctc atgccgactt tgatgccaag 3091621 atcttccgca gcgtacgtga cggattctaa aggtgcgtct aacagctggt caatggtgcg 3091681 gacaccaact gcgcgtcccg ccacgatgcc gcgctccttt aatttttcat tcagcagcgc 3091741 cacatcaagc gcgccgcaca taatgtatcc gtgatcattg gcgacggcca taaaattcgt 3091801 tttgggaagc tttactgtca cagctgtaaa aggctgtcct tctatcatga tcggtgtcag 3091861 gtttaccacg tcaaccactc ccttcattca tcactttatg atgaagggca cagcttgttg 3091921 tgggctgact gccttattgt gcaagcttcc aagcaagcag atcccgcaaa aattccggca 3091981 taaaatattc tttttctgca gcgtcgcgaa tcaacggaaa cagtttgccg agcgtaaaca 3092041 tatcaagcac cgcaacggag tattgtttat gtttttcaat atcttccccg ttcagtgtga 3092101 tccgagtgac gtgggtgatc ccgtcatcga gccgtttcgt ttctacctca acgccggcat 3092161 acaccatttt ccccatcact tctccgcgga agccgagtcc tttgatccgg agctgctcca 3092221 tttgttcgga agcggcatgg acaatggttt ccttcagttc ttctcccgtc aggcggacag 3092281 ccaccgggtt gatcggatgc ggacagatgc ggtgcagatc cagctttgtc acaggacctg 3092341 cttttagcgg accgagaatg acacctgaat tgaccatact gatgtccgtc tcgcaccatt 3092401 cctttaaggc gtatgccaaa agcaaaggca gctctgattc ttcaaaccac ttcacctcag 3092461 catcttgtgc aagctctgca acggcatcgg acagtttctc ctcggcttca cgttcttttt 3092521 cattgagaaa cgctttagtt tctgcggatt ctcctgtcca ttccgccatg ttctgcacag 3092581 aagccgtttt gctgttgatg cttcgctgta cgctgtccac cgtgatttct acacagccga 3092641 cataatgccc gtatttctcg gcgctggcca gcagtacccc attaaccact tgtccatctt 3092701 cgagcaaatg atgggtatgt gattcgagga ttacatcaat ctcaggcacc gcttcagcca 3092761 ctgcttgatc atcaagaatg cctaaatgtg acagcagaac gataatatca gcctgccctt 3092821 tcacttccag aatggtttcc tttatgcttt caagggcatc cgtaactgtc catcccagct 3092881 tgtcatatac aggataatac ggcacagtta cacctaagaa agcaatggac ataccgtttt 3092941 tcaatgattt gatatggtaa ggcaccgccc aggacggacg gtttccattt ttatcaaaca 3093001 ggttagagac gatgacagga aattcagcat gatcatataa ggcagcaagc tcttcatgcg 3093061 gaagcgtaat cccttcgtta ttgccgatcg ccgctccatc aatgtgaagg cggtttaaga 3093121 gatcgacatt cgcttttccg aatgtcgcct ctgtcacgaa ttgaaaacga tcaagatgat 3093181 cgccaatatc aaaaacgagc gtctcttcgc cgtctgactg atgctctttt cttttctgct 3093241 cgatataatc tacaattttc ggccagtttt caaaatggct gtgcaaatca tttgtatgat 3093301 ataagcggag cttctccttc ataatatctc tccctaatcg ttcagctgaa aatgccttca 3093361 taaatgagct ggcagccgat caaaatcaat acgatccgca tgatcataac gatcgttttc 3093421 gtctgcattt ttctgttgat ggcggcgcca agctttccgc cgaaccaagc gccgggcaca 3093481 agcgcgaggg cgtacagcca attgacgtgc ccggaaatca tatgtgaaac agaccctgtc 3093541 atagaagaca ggaaaataat aaacatggac gttgccaccg caaccttcgg cggaaacaga 3093601 aataacagca tcatcgccgg aaccatcagt gatccgccgc ctataccgaa aagtccgcct 3093661 aaaaaaccga caacaaaggc aatggcaata ccgacagagg cctgatatga gtacgtataa 3093721 ggctcaccgg catcatcctg aaatgtccgg ataattcctt tgtgcgcttt gttgattggc 3093781 cgggctttcg ctttcagcat taaggataat gaaatcagaa tcataaaaat gccaaaccaa 3093841 acggaaaacg agtttgaatt gaacagcttt gacacgtaag ccccgatcat gctgccggga 3093901 cccgaaccga taaagaaaat gagtccgctc ttataatcaa ctgttttata tttaatataa 3093961 gccaaagttg aagaaaggcc cgtaaaaata atgaccaaaa gcgaagttcc aatcgcaacc 3094021 tgcggcgtca catcctgaaa cagctgcgtc actgtgctta aaaacatcag agatggcaca 3094081 atgacaattc cgccgccaag cccgatcaga cttcctaccg tacctgcgat taatcccagt 3094141 acgaccaaaa tcacaaacga catcaatcaa aacctctttt ctaaaataaa tcgagctgtc 3094201 tcggagcaag tccgctgtac tcgatatcaa gcagttcaag catctgcttg ccattatccg 3094261 cagcgtcacc gccggaattg ttgttgaaca ggacaaaaac atccttacat tgctgctgca 3094321 attcattcag gtgctttttc caatcctcca gctcctgttg gttgtagcgg tataagtacc 3094381 tgacctcccg ccagtttttc ccgccatcag gcttcatcca gccctgcttg ttgcgtccgt 3094441 gaaacctgac gagcgttttg ttttcatcgg tcgcgcgcaa cacggtcgga acgctgcctt 3094501 ctccgatttg cggttcatca cagacactgt gaatccagcc ttccgctttc ataaatgaaa 3094561 gcgtctgctc ataaaatggc ggcgagaacc aggaacggtt tctgaattca agcgcgcaag 3094621 gaatatctcc catttggtgc ttacaccatc tcaaataggc gacattctcc ttcttgcagt 3094681 caaaccacgg cggaaattga aacagcacca tggcgagctt attgctatgt aaatatggcg 3094741 ttaaagacac cttaaacgca tcaaacatct cctcttttga gtcaaaggga atttcgccgc 3094801 gctgatgccc tgtcatgccc tgatatgctt tcacgataaa ttggaaggtt tcgggcgttt 3094861 ccttcaccca cttttcatta ttgcgcgccg gctgaatcgc gtaaaagctc gcgtctaatt 3094921 ccacgatcgg aaaatgggag gaataggcct gcaatttttt ctggctggcc gttttcggcg 3094981 gatagatgct gtcatgatcc ccccatcccg tcagtccgat ataaatcaca ctcattcacc 3095041 tctcttccag tttatcacac gtgttttcag gtttcctcgg aaatgctgtt catatggcgg 3095101 gaaaatgcct cacgcaaatg ctgatattgt tcctcattcg tatctaaaaa cgcctcttct 3095161 cttgaggaag gaatgtgctg atattcaata ggcgcctgaa actgctcact cgtaaaatcg 3095221 tacaccacac cattgatgct gttataaaaa tgccagctct catcgactct tgttttgaaa 3095281 atcgtgccgc cgaaatggtc ttgaatcacc aatgccgtca cgccgcattg gccgcatgac 3095341 gggcattctt ccgtccattt agagctcgaa tggcgcgacc aggattgctt aagtatgtat 3095401 ttgacatgct ccattgcctc cgcctccttt aaaaaaagat accacgttga tgagatttta 3095461 aaaactagaa cggaggaaat caaaaaaccc ggcggtaaaa tccgccgggc ttacgaagga 3095521 acgaccagag ctccgtcaat ttcagtgact ttttccccat cattgtacac gcaccggcct 3095581 ttgctgtaag tggccgaaat gctgcaggga aatgtatgtc cttcgtaaat gcttttttta 3095641 tgctttgcaa acatcgattc tcttgtaaca gtgtacggct ccatgctgac gagcacgaaa 3095701 tctgcatcac accccgcctc aagccgccct tttttctgaa ggccgaatcg ttttgcaggg 3095761 gccgccgctg tccattctgc gatggtttca aatggaatct gatgctcaag cgccagttcc 3095821 agcattccta ataaagtgaa ctgcccgccg ctgattccgc cccatgataa aaacatgtta 3095881 tcctcccgct tcaaggatgg acggcaaggg gaatggtctg aggaaaccat gtcaatgtcc 3095941 ccggcaatga gcgtctcgat cagcgtctct tttgattgcc gtgaccggag cggaggcgcg 3096001 cattttgcga cagagcccct ttgccgtaaa tcgtcatggc tgaacaagac ataatgcgga 3096061 catgtttcaa ccgaaacatc aagaccttcc tgtttcgcct ctctgatcag ccggaccgct 3096121 ttcgccgtgc tgatatggac aaaatgaacc ggacagcctg tcaccttcgc atactgaatc 3096181 gtgcgataca ccgcttcaac ttctgcttcc tccgggcggg aggcggcgta cgcatccgca 3096241 tccacctttc ctttattggc caaaaccatc tgcaagtagc ttgtgatcgc gtcgctttcc 3096301 gcgtggagag cgaggatttt tcctgcagcc gcgatttctg ccatgccttt gagcaatgtc 3096361 cgttcatcaa cagagcggaa ctcatcagtg cctgactttg ataaaaacgc tttaaacccg 3096421 atcgctcccg cttcagccat cggacggatg tcctcgatat ggcctggcac aaggccgccc 3096481 catagcgcaa aatccacggc agatttttgc ctgcctagct cagcttttgc gagaagatgc 3096541 tctgccgtca cggttgatgg aatacagttg agcggcatat caaaataggt agtgcaaccg 3096601 cctgcggcca tcatttgaga acctgtttca aacccctccc aatcctccct gcccggttca 3096661 ttaaaatgaa catggcaatc tatcacacca ggaaacacgt atttcccgtc tgcctggatg 3096721 atttccgtcc cgcttgcttc aatgtcagaa cctatctcgg caatgacacc gttttgaact 3096781 acaatatcag cttctataac gccatctggc gtaactgcct tcgcaccttt tatcaccata 3096841 tcgtaagcca tattgatccc cccatgtcag gatgacgatt ttccatgtca gtttatgtaa 3096901 cacaaccagt tctattttca acagtttact gctactatga tcgtattaca tcagcaaaac 3096961 cgctagaatt cctattgaaa attattcacc ttaaccaatg tttttataga aaaggagaat 3097021 gcgctatgaa tattcttgat gtgatgaaaa taccggcttt tgaaaacgcc aatttaatcg 3097081 ctggaaaagc aggaggggaa agagaggttc agcatgtcaa tatgatggac gctccggata 3097141 tcgtagactt tttgcataag aatgaattgc tcgtcaccac cgcctatcac ctgaaggatc 3097201 acccgcatca attatctgaa ctgattcggc aaatggcaaa acgcggctgc gcgggcctcg 3097261 gcattaaaac aaagcgctat ctggaagata tcccgaagga aatcatcgaa ctggccgatt 3097321 catatgcgtt tccgatcatt gagcttccgg aacacatccg actcggcgat attgtgaatg 3097381 ccacactcag ccatattctc gatatgcgtt ctaacgagct gcagcaagcc atttacgcgc 3097441 acaaaaaatt cacaaaccac attatgagcg gcaaggggct gcaatccctc ctcaaaaagg 3097501 tgtcagacat ccttcagctt cccgtgctgc tgcttgacca gcatgccaaa atgctgtctg 3097561 cgtctcatca gatttcagtt gagaccgaaa agctgaaagg caccctgaat accgtatccg 3097621 ggccattttt cacttgtttc tctacaatct cagatcagaa aacatattct gtcctgccta 3097681 tttataatca cgaaaaaaac tgcggctacc tgctgatacc cgacatggtg caggcaggcg 3097741 acaaaggatt gatcctcacg attgaacaag cggccaacgt catttccttt gaactgctga 3097801 aggaaaatgc gctgaagcag ttcagccggc gggcccgcaa tgagtttttc aacaatttta 3097861 ttgagcggac cttttcttca gatgacgaaa tcaaaaaccg ggcgaaagaa ttcaagctgc 3097921 gctgggatca aaaatacatg tgcatcgccg gcaaactcga tcgcaatgac gaatcaatca 3097981 gctttacaga aaatcagctc gcttccgaca gcgtattcga atttcttgaa ggtgaattat 3098041 cagccttccc gtttccacct cacttcttta tgaaaggaaa tgtcggcatt attctaatcg 3098101 aggcgacaga cagctggagt gaaatgcacg cctcggtgat cagcttttta gaacagtttc 3098161 aaacacaggt cagcgctcaa tttaaacgaa ccgtgtcctt tggcatcagc aatatctgcc 3098221 aaaagctcat tgatgttccc gacgctttca cagaagcttc tgatgctctg caatcggggc 3098281 atttgtcaag aagcaccgca tttatccagg tgtatcacgc caaagatgtg cctgagcttc 3098341 tgcgcttgct cccagttgag gatttgaaga aattttacaa ctccacgctt cagagcctcg 3098401 ctgaaaaaca gcaggaggat caaagcctgc ttcatacgct ttccgtctat ttagagacac 3098461 actgccaaat ttcagagacg gcaaagcgtc tgtacgttca tcgcaatacg gtcatatacc 3098521 gccttgaaaa atgcgaagag cttctgggga aaagcttaaa agatcctgaa acaacgatgc 3098581 gtttgcggct tgcattacgt atgcagcggc tgatcagcta aagtttgtta cattttctta 3098641 caaaacgaat cgtttttcgt cactttcagc aatcacacct gtctttttca gctactgtat 3098701 ccaatgacac ccctcgaccg gaacgatatt atgttactaa agttcacata cagggaggga 3098761 ctatagtgaa aaaaagatcg tttaaggtgt ttacacttag cctgcagcat gtgctcgcca 3098821 tgtatgcagg tgcgattttg gtgcccctgc ttgtcggcag ggcgctgaat gtaacaactg 3098881 aacagctgtc ctacctattg gcgattgacc tgttaacatg cggcgtcgct acgcttttgc 3098941 aaaccttgcg cggaacatac atcggcatcg ggcttcccgt catgcttggc agttcatttg 3099001 tggccgtcac cccaatgatt gcaatcggca gcaattacgg cattcacgcg atttatggtt 3099061 ccatcattgc ggccggtgtg ttcatctttt tgtttgcgcg ttttttcggc aagctgactg 3099121 tgttatttcc tcctgtcgta acaggtaccg ttgtgacctt gatcggcctt tcacttgttc 3099181 cgacaggtgt gaaaaatatg gctggcggcg aaaaaataaa cggcagcgcc aaccccgaat 3099241 acggttcgct cgaaaacctt cttctctctg tcggtgtcct tgttctgatc ttagtcctca 3099301 accgctttct caaaggattt gcccgaacac tgtccgttct gatcggcatc gccgccggaa 3099361 cagcggcagc agcgatcatg ggcaaagtca gcttttcttc tgttacagaa gcaccgttct 3099421 tccaaatccc gaagcctttt tacttcggag cccctgcgtt tgaaatcggt ccgatcttaa 3099481 cgatgctgat cgtcggaatc gtcattattg tggaatcaac cggcgttttt tacgcaatcg 3099541 gaaagatatg cggcagacct ttaactgaca aagatctcgt caaaggctat cgagcggaag 3099601 gaatcgccat tctcatcggc gggctgttca atgcctttcc ttataatacc tttgcgcaaa 3099661 acgccggctt attgcagctg accaaagtga aaacaagaaa catcgtcgtt accgcaggct 3099721 gtatccttgt ctgtctcgga ctgattccga agattgccgc ccttgcatct gccgttcctg 3099781 ctgctgtact tggcggcgcg accgtcgtca tgttcggcat ggtgattgcc tccggcgtca 3099841 aaatgctcag cacagcggat ctcaaaaatc aataccacct cctgaccatc gcatgctcaa 3099901 tcgcactcgg catcggcgcc agcacggccc ccgggatttt tgctgaattc cccgctccga 3099961 tccggattct ggtcagtgac ggcaccatca ccggaagcct aaccgccatc tttttgaatc 3100021 tatttttcag cttgcgcgac aaaaaagaat taacagcaca gcaaacagaa cttccggtat 3100081 tagaacatac actcgcatta gaaaaagagg tgtaaaaaag atgaaggaac agcacaatgc 3100141 cttacagcta atgatgctgg ggcttcagca catgcttgcc atgtatgcgg gagccattct 3100201 cgttccgttg atcgtcggag cagcgatcgg gctgaatgcg gggcagctga cgtatttaat 3100261 cgcgattgat ttgtttatgt gcggggcggc aactcttttg cagctctgga gaaaccgata 3100321 tttcggcatc ggccttcccg ttgtgctcgg atgcacgttt accgcagtcg gcccgatgat 3100381 ttccatcgga agcacttacg gtgtcccagc gatatatggt gccattatcg ccgcaggact 3100441 gattgtcgtc ttagccgcgg gcttcttcgg gaagcttgtc cgtttttttc cgcctgtcgt 3100501 aaccggatca gtcgtcatga tcatcggcat cagcctgatt ccaacggcaa tgaataacct 3100561 ggccggaggt gaaggaagca aagaattcgg ctcactcgac aacgtgctcc tcgggtttgg 3100621 cgtcacagct tttatcttat tgctgtttta tttctttaaa ggctttatcc gctccatagc 3100681 gattttactc ggtcttatcg caggaacagc ggctgcatat ttcatgggaa aggtcgattt 3100741 ttctgaggtt ttggaggcgt cttggcttca tgttccgtct ctgttttatt tcggaccgcc 3100801 aacctttgag ctgccggctg ttgtcacgat gcttctcgtt gcaattgtca gcctcgttga 3100861 atcgacaggc gtttattttg ccctcgctga tatcacaaac cgcaggctgt cggagaagga 3100921 tctggaaaaa ggctaccggg cagaaggcct tgcgattttg ctgggcggct tatttaacgc 3100981 gtttccctat acagctttct cgcagaatgt cggcatcgtt cagctctcaa agatgaaaag 3101041 tgtcaacgtc atcgccatca caggaatcat actggtcgcg atcgggctgg ttccaaaagc 3101101 agcggccctg acaacagtga tccccacccc agttctcggc ggcgcaatga tcgtcatgtt 3101161 cggcatggtc atttcttacg ggatcaaaat gctatccagc gttgaccttg attcgcaagg 3101221 caacctgctg attatcgcct cttccgtcag cttggggctt ggcgctacaa cagttcccgc 3101281 gttgttttca tctctttcgg gcgcggcctc tgtcttggca ggaagcggaa ttgtgatcgg 3101341 cagtttgacg gccattgcac tgcacgcttt ttttcaaacc aaacagccga atagcgcaga 3101401 cataaaaacg taaaggaaga tgccaatgtt cacaatggat gacctgaacc aaatggacac 3101461 acaaacactg acagacacac ttggctctat ttttgaacac tcttcatgga ttgcggagag 3101521 atccgcagca ctacggccgt tttcgtccct ttctgatctt caccgcaaaa tgactggcat 3101581 tgtaaaagct gcggatcgcg agacacagct tgatttaatc aaaaagcatc cccggctcgg 3101641 aacaaagaaa acaatgagcg atgactcggt acgagagcag cagaacgcag ggctcggcaa 3101701 attagaacag caggaatacg aggagtttct catgctgaat gaacactatt atgatcgctt 3101761 cggctttcct tttattttag cggtgaaggg aaagacgaaa caggacattc accaagccct 3101821 gctggcaagg cttgagagcg aacgagaaac ggagttccag caggccctta tagaaattta 3101881 ccgaatcgcc cgctttcgtc tggctgacat catcactgaa aaaggagaga cgcaaatgaa 3101941 aagaaccatg tcttatggca aaggaaatgt atttgcatac cgaacgtatt taaaaccgct 3102001 cactggagtg aagcaaatcc cggaatcatc ttttgccgga agagataata ccgttgtcgg 3102061 cgttgatgtg acatgcgaaa ttggcggaga agccttcctg ccatcattta cagacggaga 3102121 caacactctc gtcgtggcaa cggattcaat gaaaaacttt atccagcgcc atctcgcatc 3102181 ctatgaagga acgacaaccg aggggttcct acactatgta gctcaccgat ttttagatac 3102241 ctattctcat atggacacga tcactctgac tggcgaagac attccgtttg aagcaatgcc 3102301 tgcatacgag gagaaagagc tcagcacaag ccgcctcgtc ttcagaagat cgcgtaatga 3102361 acgaagccgc tctgtgctga aagcagaacg aagcgggaat accataacga ttacagagca 3102421 atacagcgaa atcatggatc ttcagctcgt caaggtgagc ggcaactcct tcgtcggctt 3102481 catccgggac gaatatacga ctctcccgga agacggcaac cgcccgctgt ttgtctattt 3102541 aaacatcagc tggcaatatg aaaatacaaa tgactcatac gcttctgatc cagcacgcta 3102601 cgttgcggct gaacaagtcc gcgacttagc gagcaccgtt tttcacgagc tcgaaacccc 3102661 ttcaatccaa aacctaatct atcatatcgg ctgcagaata ttagcgaggt tcccgcagct 3102721 cactgatgtc agcttccaat ctcaaaatca cacgtgggat acggttgtcg aagaaatccc 3102781 gggctcaaaa ggaaaagtct acaccgaacc gcgcccgcca tacggtttcc aacattttac 3102841 cgtgacaaga gaagacgccg agaaagaaaa acagaaagcc gctgaaaaat gtcggagcct 3102901 gaaagcctga tgggaaaact gacaacccat attttagatt taacctgcgg caaaccagcg 3102961 gcgaacgtaa aaattggatt gaagcggctg ggcgaaagta ttatgaaaga ggtatacact 3103021 aacaatgacg gcagggtcga tgtccctctg ctggctggtg aagagctgat gtcaggagag 3103081 tatgtgatgg aatttcatgc aggagactat tttgcgagta aaaacatgaa cgcagccgat 3103141 cagccgtttt taaccatcgt caccgtccgt tttcagctag cagatccaga tgcacattat 3103201 catatcccgc tcttgctgtc gccgtttggt tatcaggtgt atagggggag ttaagaagga 3103261 agcccgcctc accggcgggc ttctttttgc acttcaatta acttttgatc ctaggacagt 3103321 acttgaagtg atccccacac ttagtgaaac aacagctaga ataaacattc acctatattt 3103381 ttcaggataa ttgcctacga gaaaaatacc ctgtagtcct ttcatttata aatcgaggtt 3103441 tcaaactaat aagtcagctc ttagcagccg agctcccttc tccaatccta taaacagacc 3103501 gcgttttttc tcgaaaaaat actctgaaga caattgctgc gtttttaata gttttgataa 3103561 cgcgttctct cttacacctt tagacaaaat attcattttt tcttttttag acttaaatct 3103621 atgtcgaaaa taatcgttgg catatcttat cctatctcca ctaaaggagg tgacattatg 3103681 ggattctaca attctggtgg atacagtgga aactctggtt actcaaacgg tttcgggagc 3103741 tccttcgctt tgatcgtggt gctattcatt ttgttgatca ttgttggagc agctatcttt 3103801 aattattaag tttaactttc cttgcctccg ccgtatccaa cacctccctg tccgacagac 3103861 gccataagaa gtttttatgg cgtctttgct atgtgttcac taatcttttt gtaatccaga 3103921 agctgtcaag ttctacgaga tttatcgtgt gttttcccac aacgcttctg cgtcttgatc 3103981 gcgctgtctg actgaggcta aaaaagtccg gcttttaaaa gccggactcc cgtctacccc 3104041 cgttcaactc tcttctaatc ctgcaagctg accgcataat cccgccatac ccggtacacc 3104101 ggcacaaatt ccccgccagc ccttcttcta tatctttgtc agaaggttga ggggtttccc 3104161 gaaacaatgc tttaagcgca atgatcattc ccggcgtaca gtagccgcat tggaagccgc 3104221 cttcttccag gaaagcggtt tgacacatat ccagctcttc tttttgaagc ccctcgatgg 3104281 ttgtgatgga atggccgtct gcttgatagg ccatcgtcat gcacgcattg gccagttttc 3104341 cgtcgattaa aatagagcag gctccgcagc ggccgattcc gcaggacacc tttgtcccgg 3104401 tcagctgaaa ttcctttcta agcaggtcac tcagatgtgt cgtaggaacg gcagcaacct 3104461 cccacgcctg accattcacg gtcatccgga actgttcctt ttttacagga aatggcccgg 3104521 cctcttttat gtccattgct tcagcccctt tctgtcgatc gcttcaagca actcttctct 3104581 tgaaattggc agcttgttta tccagcatcc gaccgcatca tgtactgcct ttacaatcgc 3104641 cggagtgatg gcgattgttc cgatttcacc aacaccgcgc ggtccatata cgtctccctt 3104701 cattaagtct tctattgcaa tcagcttcat gtcaggaaca tctttgattc cgggaatcaa 3104761 atagtgatcg agattttccg cagcataacg gccatccgtc attttcgctt cctccatcag 3104821 tgtgtagccg agtgccatgg cagcgccgcc ttcaatttga cctcgatatc cctgcggact 3104881 gacaaccgga cctgccgcaa tagcgtgctc acaatctatc aatttgacat cgcctgttaa 3104941 cagatctacc tccacctcaa cggcagccgc tccaaatgag tagaggaaat ggccgcccac 3105001 cacaggatca ggcgttgttg gaaagtcaaa ggccgtttcc tctgccaaag ggcctttttc 3105061 agccagctcc ttatacgtca ccacgagcgc ctttgtgttt ttgtcacgca agcctgcagc 3105121 gccgggaata agattttccg ctgaacagcc gctccattct gccgcccgtt ttttcaactg 3105181 agctagaaac ggcttcttca aacgctggat cgcgtgccac accatgcttg tgccgcggga 3105241 tgctgtggag gagcctgact tcggcacttt tgcggtatcc ccaataacaa tggaaatatc 3105301 ctctgcggca caacccagct cctccatgac aatctgttca atcgctgcta gaatcccctg 3105361 tccgcattct tcaaatccaa acgaagcagt gattttgcct tcactcgaaa gagacaaacg 3105421 gcctcctgcc gcatccattc ggccaaaccc cagcccgccg ccgtgcattg taattgccgc 3105481 tcccgtgcct ctttgcagat acccgcagtt ccggcttgtt tttttaagaa tgggagattt 3105541 agatatggca ttcaacacct gtgccgctcc gtcagttggt gcaattcgat gctcaagcgg 3105601 ccccaagtca tgcggttttc tgatattttt tcttctcagc tcgagcgggt cgatgccaag 3105661 catgccgctg agacgatcga gatgggtttc gagtgcaaat gtgatttggt tgccgccaaa 3105721 gccccgaaat tcccccgcca ccccgttgtt cgtaaatact gatattcctt cagtccggat 3105781 attcggaata cggtacggcc ccgcggcatg ctcgacagaa aaatcaagaa cagccggtcc 3105841 gagcgtagcg taagcgcctg tgtccgccac aattttcacg tcgtgcgcca atagatttcc 3105901 cgaatgatct gcacccgttt ttatcgtaat cttcatcgga tggcgcttaa tgccagaacg 3105961 tacagattcc tttcgtgtct gatgaatttt gacagggcgt ccgcttttca gggccaaaag 3106021 cgcagcatac ggctgaatat tcagctcatc cttccctccg aacgagccgc ccatcggact 3106081 tgacacaatt ctgatcttct cttcaggaat atcaaaaata cgggcaagct ggaaacggtc 3106141 tttatagccg tgctgggttc ctgcatacat cgtaaaaccc ccgtcgtctt ccggaacggc 3106201 tacacctccc tccgtttcca tatacgtatg catctgccgc ggcagctcat aggtttcttc 3106261 aaagactgtg tcagatgctt gaaacccttc ttccacatca ccgtttgaaa aaaatgcgcg 3106321 gtgcaggata ttcccgtcct catgcagtct ttgcgcattc ggccgaagcg ctttttctgg 3106381 tgaatccatg acttccagct ctttatactc aacttgaatc agctccagcg ccgcttccgc 3106441 gatttcttcc gtttccgcag caactgcggc gatcgcatcc ccgacatacc gcaccctgtc 3106501 ctcacataaa accggctgat cagggatgac aatgccaaat cggtttaagc cgggaacgtc 3106561 tttatgtgtg acgacggcct gcacgccttc cattttctca gcttttatgg tgcaaaccga 3106621 cacaatctct gcatgaggat aagcacttct cagcaccttg ccatacagca ttcctggaaa 3106681 gctgagatcg gtcatatatt tcaattcccc tgtgacctta ccccttccat ccggcctgac 3106741 tcttgacggt ttgttgatga tcatttattc ccctccctca gccatcagct ctgccatgat 3106801 gacgttggca gcggcttttt ttctgtatgc cgctgacata aaaacatctg aggaaaacgg 3106861 cagctcatgg ataagtgttt tgtacagctc atgcgggtcc caccctggtg ccatccattt 3106921 cgcttcgctg tccaataatc tcctaggagt gatatcggca tggccagcgg cgaggcgaat 3106981 gctgccgtct ttcaaaaaac gtccagctgc aacagcagcc gctccggtaa aagcctggcg 3107041 ccttccaagc ttgtgataaa atacacgctc tccctccgcc cgcgggatga tgacacgcgt 3107101 gacgatagcc gttctaaagt cttcctcact gagccaagcg ccaagcggca gcctgattag 3107161 ctccttttga tatacgataa gctcagcacc aagcacaagc agaagcggaa tgaaatcacc 3107221 gattttactc gctatgttgc cgccaatcgt ggcacggctg cgaatccccg gtgcagcgac 3107281 agcggaagca gcgtcactga aacagctaag cgctctctta atcaaagggt tctttctgca 3107341 ttcattcagt gatgtgagcc ccccgatcga cacgtgggtg tcactggtgc tgatccctcg 3107401 catttcgtca atcccttcaa ggctgacaag gtgctgtttc ggtagagttc ctttgtccca 3107461 ctgaagctga aggagcgtgc ttcccgatgc ggcacacaca tccggagcaa gcttctctaa 3107521 aagcgaatag gcctcatcaa gcgctgccgg tctccataat tgaatattca tccttgcttt 3107581 tgtcacttgg ccgttcaaga catcgccctc cttaccatgt catattcctc gggtgtatca 3107641 atatcgtcca actcaccgct atcctttgcc tccaaaaccg ctcctgctcc aagctgtccg 3107701 cttttcagga gcctgcgagc cccttcatct ccctttaatc cctttacata aggaaaacat 3107761 gtcgacgaga agtagattgg cggggtgaac gcccctaaaa acgatgacac ggcaaatgac 3107821 tcaggagcca gagccacaag ggcattgaga tgatcgacgg aaagctgagg ctggtcggct 3107881 aacaaaatga caatgccgtc cgcccccatg ctttctgctt ttctcacccc gctgctgact 3107941 gaatgcccct gacccttttc tgcgtcttgg caaacgtgca ggctccagcg tttttgaaaa 3108001 ggcggagcgt gatacggcgc tcctatccac tcaagggagg catgttctgt ccgctcgacg 3108061 accagcacgt gatcaaggcg ggacgacaga gcagttttca aggaaagtga gcctatgttt 3108121 tctcctttta gcggcaaagc cagcttgttt tgtcccattc ttctgctttt gccggcagcg 3108181 agaaacacgc cgatcagata ggggcttctc atacaaccgc cacccgtttt cttgtttgaa 3108241 tgatttctgc aactacactt accgcaattt cctcgggacc ttccgcaccg attttcagcc 3108301 cgaccggact gtaaaagtga gacggaggat gttttccgct cagcagccgt ttcgtgcggt 3108361 ttgccgaacc caacagtcca atataatgga ggttttgaga aaataagaag ttgatgatcg 3108421 tttgatcgtg ctgataatga tgggttgcca caacagctgc atcatgcgga aaaaattgaa 3108481 attcgctaag catttgttcc ggaaaagcgg tgatcagctg atccgctttt ggaaaaagag 3108541 aggatgtaca ataagcgggc cgccaatccg tcacgataac agaaaaccct gtgtcagccg 3108601 ccaaattggc cagcggtaca ttatccggtc ccgccccaaa cagaatgaga cgcggcttcg 3108661 gttcaattcg ctgaataaac atgttagtgg tttgatcgaa atgcggtaaa tgaagcgttg 3108721 aaacagtacg ttgaatatct tgcagaggcg cgtccggcca gttcccaaaa tgtccgttct 3108781 ccgtcagaaa taaataatgg gaggattcaa tctttataac ggaagtgaca gctttgcctg 3108841 aatgaaggca gtccctcact ttctcatagt gccgcctttt ttcctgagtg attcgctctg 3108901 catgaacatg aataatgcca ttgcacccgg ctcccatgcc ccaagaaaga tcgtcctccg 3108961 accgcatgtc gtagggaatc agcgttgatg tgagctgatc gcccagcgca ctgattcttt 3109021 ggaatacatc ttcttccaca cacccgccgc tcagcaagcc aatccgtctg ccttttttct 3109081 taaagagcat agaggcgcct gcttttcgat acgcggagcc ttcaacttga acaattgtcg 3109141 ccagtacagc ctcctcctgg tcttccagga gcgcatctaa catcgtgtga aaattcccca 3109201 atgccgcatc ctcctctcga aaattgccgt gagaaacaac tagttcagcg tgattttata 3109261 ggtaacttgt ataaagaata gacgatggaa gaaaaaatga ctcatgattt gtcagaaaat 3109321 gaaacacata gaaagaggat ttgtaaaaag agtcaaacga agaaaatcag attggagaaa 3109381 acacgaaatc atatcgttaa aaagcttgcg gagttccgca agcttttctt tacaccgctg 3109441 cctggcggcc agcgttttca tacacatcca gcgctgcttg gagcgctttt cctgcttcga 3109501 ttcctgcgtt atgtctgaga agcacagcct ctaacccggc aagcacgaat agcacgtttt 3109561 cttttctgca gctgtacccc atcgtgccga tcctccagat cttccctgca agcgggccga 3109621 atgagctggc gatttcaatg ccgaattgtg ccagcagcat gtcacggaca gactcgccgt 3109681 caatgccgcc gggaatttcg acacaggtga caacaggcat tttgcagctg tcatctccaa 3109741 acaatcttag ccccattgcc tttatccctg ctgctaatgc ggcttcatgg tgccgatgcc 3109801 gctcgaaacg cgtctcaaga ccttcttcaa gcaccagtct gactccctca cgtaaggcgt 3109861 acagcatcgt cgtcgcttct gtatgatgat tgagccgtct ttcgctccaa taatcctcaa 3109921 gctggctcaa atcaaagtag ttgcttgtaa ttggccgatt tcccgaaagt gctgccctgt 3109981 cagcttgtgt cgcaatcccg cgttccacct ttttgcgagc tgcaatcacg tccgccaccc 3110041 gctcattata tgtaatcggc gccattcctg aaggcacaga caaacatttt tgcgttccgc 3110101 cgatggcagc gtcaatcttc cattcatcga ctttaacctc gcagccccca atcgttgcga 3110161 ctgcatcgac gataaacaat gcatcctcgg tgcggcaggc ttcgccgatg gctttcagcg 3110221 ggtgaatccg tcctgtcgat gtttctccat gcaccatggc cacaattttc ggcttcactt 3110281 tttttatctc ccgtatgatg tcctccgggt caaaaaccgt tccccattcg cactccagca 3110341 tatgaacatt tgccccatat cgctcggcga tttcagtcag caaataaccg aaacggccgt 3110401 aaatgggaat gagcacatca tcttccggct ctatcacact agccagcact gcttcaattc 3110461 ccgcccgtga agtgccgtca atcgggtatg cccagcggtt ttttgtttgg aacagctccc 3110521 gaagcatctc catcgtttca ttcataatac ctgtaaacgc cggatcaaat tggccgacaa 3110581 ccggggtgct cattactctt aatacacgcg gatcaacctc aacaggcccc ggtgtcataa 3110641 tcgttcttaa cggggtgcat aattctcttc tgcctgacac agccattcct cctttatcag 3110701 taagccagtt tgtataataa atcagtcagt gcgcggacgc cgatctcaag ctgtctggct 3110761 gacgtatatt ccttcggtga gtggctgacg ccgcctcggc tcggcacaaa cagcatacaa 3110821 gcaggatagc gccttccgat catttgcgcg tcatgccctg ctccgctcac catttcctca 3110881 cagctgaagc cgttttctaa tgctgtttca aaagccgcag ccttcagcct ttcgtccatc 3110941 ggcacaggct ctatccgcat atattcatca atcacagcgc gaattccttt ttgtaggcaa 3111001 atgccgttga tcaaagcaac catgtcttga tgaaactgtt ccagcacatg ctgatgctga 3111061 tggcgaatat cgattgaaaa ctggacgcgg cccggtatga cattggctac attgggctct 3111121 gccgttattt ttccgcatgt cagacggagc tcatccggca gctcatccga ccgcagcagc 3111181 agctcatgaa tgatacggct gctggctgcg agcgggtcct tgcgccattt catggaggtg 3111241 gttcctgcgt gattgcattc tccttcgagc gtgacgagat atcgtctctg ccccgcaata 3111301 cttgtcacga tgccgagatc ccggcctgac atttccaacg tcttcccctg ttcaatatgc 3111361 agctcaacaa acgcgctgat atctgtccta tatgctgact gaaacacacc tttgccaaaa 3111421 ccgctctcat gcatcgctgt ttggagggag actcccgact cgtctcttgg ctcttttgca 3111481 tcttgttctg aaaaaacacc cgtcatattc cccgaccccc aataggtcat tggaaaacgg 3111541 ctgccttcct cctcacataa ggagaccgcc tcgagcgttt tttttggcgc tccgtatgtt 3111601 tccttgagct gctttaacgc gagcattgcc gccagaacgc cataggcgcc gtcgtatttt 3111661 cctccattga tgacagtatc gatatgtgaa ccggttacaa tgacttcatc cggagactgg 3111721 gtgcccgaaa gccttccaaa cacattgccg acatcgtcga atcttgtttc aagcccgaaa 3111781 gaagacattt ccgttttcac agcaagctgt gcgtccatcc actcttttgt gtataaaagc 3111841 ctcgttacgc cgccatccgc agacgcaccg tattgggcga gccattcaat ataatctgtg 3111901 atgctgtttt ttactgaaag cttctgcttt tccatgtact cccccctctg gccgctatgg 3111961 tgacttcatt atagaaggag caacatgata gttcattgac agattaacca aaaaaacgtt 3112021 tattttttag ccacagtatc catccagcaa ccagatacac cctacatgtc acaactattt 3112081 tgatgtaaag gtcaaaagaa aacacggtaa ggaagagagc cagcaagagc gaaagagagg 3112141 gtcaaaatgc ctttcatatg aacaagctaa gctggagagg cgatgttcgc ggaacggatg 3112201 aaaacagaaa tgccggcagc ccgcaaaaac aggacctaaa gatatggaaa caggagattt 3112261 ccgcctcctc caaagggact aatttacaat tttaatgaaa aatatacaaa atgacacttc 3112321 tatcctttat ttcaatttta gataatagat atgatctgat aaaaggaggg caagtgatga 3112381 caaaaaaagc atggtttctg ccgctcgtct gtgtattact gatttccgga tggcttgcgc 3112441 cagcagcttc agcaagcgcg caaaccacat taagccttaa tgaccgattg gcgtcttccc 3112501 cttcaggaac gggaagcctt ctctcattag ccgcccccgc tgcaccctat gctgacacag 3112561 atacctatta tgaaggggct gaaggtaaaa caggagactc gctaaaaagc accctgcacc 3112621 gtattatcag cggacacacg atgctgtcct acagcgaagt gtggaacgcg ctgaaagaaa 3112681 cggatgaaga cccaagaaat ccgaataacg tcatcctgct ctatacgaat gaatcgcgtt 3112741 ccaaaaacct gaacggcggc aatgtcggcg attggaaccg cgagcatgtc tgggcgaaat 3112801 cccatggcga ttttggtacg agcaagggac ctggtactga tattcatcat ttgcgcccgg 3112861 ctgatgttca agttaacagc gccagaggaa atatggattt tgacaatggc ggcactgaat 3112921 atgcgaaggc acccggaaat tattatgacg gcgattcatg ggagccccgc gatgatgtga 3112981 aaggcgatgt tgcccgcatg ctgttttaca tggctgtccg ttacgagggt gatgacggct 3113041 atcctgatct tgagcttaat gataagacag gcaacggctc agctccttat catggcaaac 3113101 aatctgtcct gctcgaatgg aataagcagg atccggttga cgaccgcgag cggaaaagaa 3113161 atgaaatcat ttatgaaaaa tatcagcaca accgcaatcc atttatcgac caccctgaat 3113221 gggcggatga gatttggccg taagaaaaag gtgctccttt tgaggagcac ctttttctaa 3113281 tacacagcct cttccgtttc cgcatcgaaa aagacgacgt ggtccatttt cactgagagc 3113341 tggattgaat cgcctgcatc gattcgcgtg tttccgtcca ggcggacctt gagccgctcg 3113401 tccccagcca tgacatgcac tatgagctcc gagcccagat tttcattcac ttccacgttc 3113461 gcttgaaaca ctgaatcaaa caactggtca tttcctgtca tttgtgtgat gtgctccggc 3113521 cgtacaccgg caatcatctg ttctccggca tatccctttt ccttcagccg ctttgctttt 3113581 tcttcaggaa tatgaagccg gatcgaagaa tttgtgaaaa acagctcgcc atgctgctgt 3113641 tctatgatgc ctttcaaaaa gttcattccg ggagagccaa tgaagcctgc gacaaacaaa 3113701 ttggccgggt aatgataaat gtcatgaggt ttcgccactt gctgaatttc cccttcattc 3113761 atgacgacaa tccgatctcc cattgtcatt gcttcggtct ggtcatgcgt gacataaatg 3113821 atcgttgcct ctaatcgctg gtgcagcttg ctgatttctg tccgcatcgt cactcttagt 3113881 tttgcatcca gattagaaag cggctcgtcc attaaaaaga ccttcggctc cctcacaatc 3113941 gacctgccaa gcgccaccct ttgccgctgc ccgccggaga gcgccttcgg ttttctcttc 3114001 agcaaatgtt caatttctaa aattctggct gccgcatgaa cccgctcggc aatttcctgt 3114061 ttcgccatct ttctgagctt taatccaaac gccatattat caaaaaccgt catatgcgga 3114121 taaagcgcat agttctggaa taccatcgca atatcacgtt ctttcggcgg aagatcattg 3114181 acccgctccc catcaataag aagatttcct tcagaaatgc tttctaatcc agccaccatc 3114241 cgcagcgttg ttgattttcc gcatcctgac ggccccacca gcaccaaaag ctccttatcc 3114301 tttacatcta aatcaaagtc cttcacggtt aattgtgagt gatatgattt tttgacgtgt 3114361 tcaaatgtta atgaagccat cagaaaagtc cccctatctt ttgacccgtt atttcgtcac 3114421 tggaaacaac ttggtctttc tgttattttt agagtaatcg attcccattt ttgctatatt 3114481 tctaaaataa aaaatgtaaa tttgtattat aacgtcataa tacattataa tataaataat 3114541 aggttaaaag gaggctaccc tttgttaaac aacggaagtt ctacaccttt atacattcag 3114601 ctaaaacaaa tcatcactga tgacatcaaa aagggcgtgt attccccaac cgccaagctg 3114661 cctaccgaaa acgagctttg caccaagtat aacgtcagcc gcatcaccgt caggaaagcc 3114721 attctcgatt tagtcgaaga aggctatctg atcaggcagc agggaaaggg aacgttcgtt 3114781 aaaagcccta aattaaaacg agagctgatc gctgtaaacg gctactcgga atttatggaa 3114841 tcaaccggca aaaaaccgaa gcatcatgtg ctgtcccatg acatcattcc agcgtcaaaa 3114901 cccatcgccg aaaagcttca aatccaaccc gagagccctg tggttgaatt aaaacggatt 3114961 ttatataatg atgatcagcc tctcaccttt gaagtgacgc attatccgct tgatttgttt 3115021 cccggcattg atacctttat tgctgacggc gtctccatgc atgatatttt gaaacagcaa 3115081 tacaaagttg tacccacgca caatacgaag ctattaaacg ttgtatatgc ccaacaggag 3115141 gaaagcaaat acctggattg tgatatcggg gatgcgctgt ttgaaattga taaaacggct 3115201 tttacatcaa acgaccagcc aatctattgc tcattgtttt tgatgcacac aaaccgtgtc 3115261 acttttacca tcaacagccc ctacacataa caggcataaa aaacgagaca ctgcttatag 3115321 tattctcgtt ttttcactgc ttcccccgtc ctccaagcga taaggatagc catagccgaa 3115381 agctccgtac acaccgcaag ttttcgcagc cgtttcagca gcctggcgca aagcatacgt 3115441 tatatcctgc ttcacgcaaa aggcagtcaa aaagcctgct ataaaagaat ctcccgctcc 3115501 aagtgtatct attatatcag cttccacaat cggctgatga tagactcgat cacccgcaga 3115561 caggattgct ccttggcccc ctcgggtcat acaaaccatt ttggctccgt acccatgagc 3115621 tgttttggca agctcaccgc attccgactc actcaaatcg cttcctgaaa aaaacgcata 3115681 cgtcacataa ggacagaccc tcctcaaata atcatcctcc cgattggttg aaaaatcaaa 3115741 tgagaccggg accagcccgc acagctgcgg aagatcgttc tcaagcctgc tgtacacgct 3115801 cgtatgcagc agatcatgcc cgctgataaa agatacatct ttctcctgaa acgcgaggcg 3115861 aagccgggac tgaatgccgc ctttatttga tctgacaaaa atgcggtccc cctgttcatc 3115921 aagggtgaca atcgccatcc cgttttctcc gtgcgcctgg cggatataat ctgcattgac 3115981 ctgctccagc ttgagaacgt tcaacagatg cgccgcggct tcgtcattgc cgacgattcc 3116041 gatataggaa gactcatgcc cgagccgctt ggcaagcaca gcaacgttta aggcatttcc 3116101 tcccgggtaa aatgtttctt gatcctggta gtaatctaca acattatctc caaccgcaat 3116161 caatttcata gcgcttcctc ctttatcctt ttacactgcc gcttgcaatc ccgcggacaa 3116221 aatatttctg catcaataaa aatagaataa taatcggcgc ggctgaaatc gttaaccccg 3116281 ccagcaggac gccccagtct gtctgcagcg cgtctctgaa ctgcatcagc ccggctggaa 3116341 tggtccgtaa attctcatca tctatgaaaa taatcgcaaa cataaactca ttccatgtat 3116401 ggtaagccgt caaaatgccg gatgtcacca aaatcggcac gctcattggt aagaaaattc 3116461 tgaaaaatac tccaaaactt gtacacccat ccaaataggc cgcctcctcc aattcttttg 3116521 aaatagaaag aaaataagag cggatcaaaa tgatggtgaa tgggatccga taagccgcat 3116581 acggcaagat taacgcccaa tacgtattgt acaggcccag cgactgaata atagaataaa 3116641 gcggcacaag actgacctgc ggcgtcagca tcaatccgcc aagacatagc accaaaaaga 3116701 atccttttcc tttaaactca aaccgggaaa ggccatacgc tgcccatgca ctgataaaga 3116761 cagtgatcac acacgtcagc gccgtaacga tgacactgtt cataaaataa gaagaaatcc 3116821 cctgattcca ggcggaaaca aaattttccg gatgccacga agacggcagc gaccagctgt 3116881 gctcaaaaat atcgtcagag tttttaaagg cgctcatcac catccagaga agcggatagg 3116941 caatcgcaat cagataaaga aacagaaaaa cccacacaga cgtttctccg atataccatt 3117001 ttcgtctagg cttatctttc acctcaatgt gctggtcagg caccggctcc aatctgaacg 3117061 aatctgtctt cttctgaggc agcatcagtt actcctcctt tccggtttta aagaacttca 3117121 tttgcatgag cgataatgca agcgtaatga ttaacacgac agtggcaatc gctgaggcgt 3117181 agcccatcat atcctttgta aaggcgcttt tatataaaaa cgtgctcaag acttctgacg 3117241 cttttcccgg cccgccgcct gtcaaaatgt acggctcatt aaagaccgta aaggctccgg 3117301 tcagcgtcat gaccaccgca acaaaagaca tctctttcgt ctggggaaca gtaatatgaa 3117361 aaaactgctg aattttaccc gcgccgtcaa gccgggccgc ttcatacagt tcatccggta 3117421 ttttttgaat cgacacgatg tacagcatcg caatataacc gacagattgc cactgggaca 3117481 caaaaatgac agaaagcata gctgtgctgt catccccgag ccaggccctc gtcagctgat 3117541 caagaccgat ggcctgaagc agctgattca aaagccctgt ctccggattg taaataaaat 3117601 caaacaaaag cgcgatcacc gtcattgaga tgacaaccgg caaaaagaaa acggtacgaa 3117661 aaaacggcga ccattttctg accagcttat cctcaagcac cgccgccaaa atcaaaccgc 3117721 caaatacctg gcatacaatt gagatcactg cataaagcac attattggta agtgcctgat 3117781 agaagacagg atcatgaaat aattcaacat agttttttaa gccgataaac gttttttccg 3117841 gagaaaatga gctccactga aacaggctga ggaatacatt ctcaaaaatc gggatataaa 3117901 cgaaaagtaa aaaaacgaga gcgggcacca aaaacaaata ggggattatt ttattctgat 3117961 tgaccaaggg tatctcatct cctttataaa aagaaaaggt gcgaagcttc accttttctt 3118021 tgatttattc agctgacgcc ctcacctgct ttgctgcctt ttgaacggct ttcatcacct 3118081 gctgcggtgt catgtcgccg ccaagcattt gctggacgcc cgttaggtac gcatctgcga 3118141 cttcaacatc gacatccata tcaaaccatg gaaccattga tttggcatca acaatatgct 3118201 gaacggcttc acgctgaatg gctgttgcat tttcttcagt agccgtacct tgcactgcac 3118261 tgtatttccc gacatctttc acgagctttt cgcccattct tttcgacgtc aagaactgca 3118321 aaaattccat cgcttccttc ggatgttttg ttcttgagga gatcatgaat ccttccggcg 3118381 ctcccgttaa cgcttctgaa gatcctttct gcccgctgat ttcaggaaat gggaacatcc 3118441 cgagattaac cggttcaacc agcttgattt ccgctgtttc cgcatatatc atcgccgact 3118501 ttccgctctt aaattgctgt ctcacatatt cgtggtcgac ggagtttaca tgtttattaa 3118561 agtaaggcat cagctcttga agcttttcaa gtgcttttac gtagccttca tcagtaaatt 3118621 cacccgtttt ggcgttatag tccttttccc gtgttttttc atcgaccatc cgctgattaa 3118681 gcgtgccgat atagtgcgag attgtccaag tcgcctttgt tccaaagctg atcggtgtgt 3118741 agccatgttc tttcagcttt tttgacacat cgattaattc atcccacgtc ttcgggggat 3118801 caagattcag cttttggaaa atgtctttat tatagaagaa tgatttagcg tccatttgcc 3118861 acggtacgcc atattgcttg ttttcataag taaatggtgt aatttgcgat tgaacgagct 3118921 gtgatgacca atcggtgtca tttttgtagt aggacgagag atcaagtgct ttattgcctc 3118981 tgataaattt aaaagcaaac tcatcgctcc aagagaagta aatgtcagga gggctggtgg 3119041 ttcccagcat gaccttaatt ttatctttat aggagtcatt taaaacggct tcaatttgaa 3119101 tgtcgatatc tgggtgatct ttttcaaatt ccttaacaac ctcttcaaaa taactttttt 3119161 ccggctcctt tggccatctg tggaaaaatt tcaatgtcac ctttccgtcc gctgaactgc 3119221 tttggctcga acagcctgcg atggtgagca tactgacagc tgcaatgatc aagaacaaca 3119281 acattttctt caaagggttg gcctcctctg gacattagac tataatgtta tataacatta 3119341 tagtctaatg cataatggtt cttcattttc agatcaatac tcaactttcc acatgtatct 3119401 tctatgagat aaaggatgat ttctctcctc tgccagctcg tctgcatagc ttctcagcac 3119461 acgattgaga acgagcggag caagatagcc tttaactgaa tcgtcaattg cagtgaagtc 3119521 gtaagatgca gcatcaagca cagtgagctt tttgccatac tttttcgaga aggtaagcgc 3119581 ccgctcttca agaggtcttg tttcatctaa accgagcagg atgataaacg gcacggattc 3119641 atcaataatt tcaaacggtc cgtgaaaata ttctccggca tgaatggcgt gggaatgaat 3119701 ccattgcatt tccatgagaa tgcagatgct gtaggagtaa gcgacaccgt agtttgcacc 3119761 gcttgccatg gtataaataa tgctttcttt ttcatgggct tttgcaaatt gcttggcgtt 3119821 gtcagcttcc tgcttaaggg ctttttcata tacagcctgc aattgatcta agccttcaat 3119881 tgcttgctca aatttcgtat tgttttctaa tacttgcagg gttccaaaaa cgatttgata 3119941 caaaacgcca tagtttgtat tgatcgcaag cgcctcatca ccccaatcgt actgggcaac 3120001 atattgcgct tcctgcgcta aaggagactc cggtttaaac gtcatcgcaa tcgtaagtgc 3120061 gcccttgccc cttgcaaacg cagcagcttt gactgtctcc ggggtatttc ccgaatgcga 3120121 gcacaaaata acaagagact tttcaccaag ctgaacaggg ttgcgctgaa taaattcgtt 3120181 ggcgctgtag agatcggagt ttattgattt tgactctctg tcaaacacat acttactcgg 3120241 atacataatg gcagaagacc ctccgcatgc gacaaagaat acatgatcaa tggttttccc 3120301 tttcaaatcc tgcaagaaag cttgaacctc acgatttact tttgctgtgg cctgactcaa 3120361 atccttcact cctcgttttt attatataac gttatataac attatatatt gttatattaa 3120421 agtccgcggg taggattgtc aatattattt tctgaaattt ctcaataatt tattcggatg 3120481 acagacaaag ggtctatatg cgaaaaaatg cccaaatcaa aagccagaac ttgacttaag 3120541 ctctggcttc gctgttcaat ccgcagactg acgtcttatt taaaaaatac cttgtctata 3120601 ttgtacttcg agtgctgtgt attgatgata tatgtttcgt aaatctctct ttccattgga 3120661 tcatcaacta cacatacctc aattttataa acttcatctc tgtgatgttt gatcggtgaa 3120721 acagtgtctt cgaaatgctt cttaattctc tgtcttaact ttctggcttt accgacaaac 3120781 agcagctcgt catgaatgtt gtaaaacata aaaatgccgc ctttgtccct tgggatctgg 3120841 tgaaagtcga tgaatccgtg aatcggtttt atcttcggct cgttatcatt agctgactgc 3120901 tgtcgttcag tgatggtgac attcggtgcg ggtatatcaa tttttatcaa aatcagttca 3120961 cgtcctcttt ttcattaaag ataaatgcta acacatacag aaaagaaaag ctagaacagc 3121021 tttattatat ttgtttgtca tgctcttact tattatgcaa gtgctccggc tggatcataa 3121081 ggactaaggt ctaattctgt ctgctttccg agaactagct ttgcgagctc tgcacccaaa 3121141 aacggcccca tcgtcagtcc agaagcaccc aaaccgtttg cagcgtacag gccttgaaca 3121201 ttcggcacgg cccctacgac cggcagaaat cccggtgtaa acggcctgaa gcccactctt 3121261 gtttcaacag cagccgcatc agcaagaccc ggtgcaacgg ctaacgcttt gctcaatact 3121321 tcgtgctggc ctccggctgt cacacgaaga tcatcaagac cggcatcgtt ttcgtgtgtg 3121381 gcgccggcta caattctgcc gttatcaaac gacagaatgt actgatcact cggcggcatt 3121441 acaaccggcc acgatcctgt atctgcatct gtcatttcaa aatgcataat ctgcgctttt 3121501 tgaaatgaca cttgaaaatg aatgccaaga ggcttcaata tctcattggc ccatgctccc 3121561 gccgtcacaa tgaccgcgtc agccgcaaac tgctttgtat ctgtttgcac gccggtgact 3121621 gttccgtttt caaaaagcaa ggacgcattt cctttgatga ccgttgcgcc gcgtttctct 3121681 gcagcgctta aaagcgaccg gcacagcgct cttccgttca cacgggcggc accgctgata 3121741 tgaaccgatt catagccgtc agctaaaatc ggaaacagct ttttcgtttc acttgcagac 3121801 aagcgggtaa tgtcgccgat ttccggcgca tcctcccgtc tcttatacgc cctttcctcc 3121861 attttatcga gtttagacgc gtcagtatga atgctgatgg caccgacacg tttgtatcct 3121921 gtatccgatt caccgtcttt ttccaattga tggattaaat ccttatagta ccgcgctccc 3121981 cccttagcaa gctggtacca atcctgatta cggcgctgcg agagccaagg acagacgatc 3122041 cccgccgccg catcagtcgc ttgtcccggc tctttccgat caatgacagt aacgcgagcg 3122101 cctgtttttg cgagatgata agccgtcgac gcgcccagaa tccctgcgcc gacgatgatg 3122161 tacgatttca tatgcaaaca ccttttctat tataatgtct attcatttta ccaaatcaaa 3122221 tgctttcctt cgaccttttg ccctaatgtg gaaaaaccgc gaagttcgtc caatctcttt 3122281 actctcctat cgaatatcct gtcactatca atagagaaag gatgatacca tgagcgaaaa 3122341 tcgtcatgaa aatgaagaaa acagacgcga tgcggcagtg gcaaaagtcc aaaacagcgg 3122401 taatgcaaaa gtcgtggtca gcgtgaacac agatcaggat caggcacagg cgcagtcaca 3122461 agacggagaa gactaatgaa cgaaaacatc attcctctta acagacatac tcaagagata 3122521 cccactactg aatctgttat caaaaacagc ggcaactcag aggtccatat cgacattcac 3122581 attgatacaa tgccaattgc ttttgctata ttatgctctg cattagccgc aaagcagatg 3122641 acaaaagagg aattcgatat ggcttatact caattgcgag agatgaacag agaaaataac 3122701 agcagatcat ctgtaaagca aattatcaat caagagacag aagaagagta aaaaaccgcg 3122761 gcccctcggc cagcggtttt tcttctgcat acaaaaagga cgcgactgaa tcggttactt 3122821 ctgtacaatt tgaataaggt taccgcatgt atcgtcgaag acagctattg tgacttcgcc 3122881 catttttgtc ggttccgtcg taaacgtcac gcctttttcc tttaatcggt tgtactcttt 3122941 ttgaatatct gcaacgccaa acattgtggc cgggaggcct tcggagaata tcttcttttg 3123001 atactccttg gcggcaggat gttcattcgg ttcgagtaaa agctcggttc cgtcttgatc 3123061 atctggagaa acaagcgtta tccacctgaa tttccccatg ggaacgtctt ccttttttat 3123121 aaacccaagt ttttctgtat aaaactccag tgccatgtct tgatcttgta caaatatact 3123181 ggtaacaacg attttcatac tgtttttccc tccttcgata tgaatgaagc atggtactat 3123241 gctaacaatc tggctacaag caaaacaacc cacacattta tcagaggccc tgttctgatt 3123301 ttataaaatt attctatcca tcctttcagc aaatttttaa gcggttcgtt gttgaatata 3123361 agtactcgat attttccctt tcgttttgat gttacgagtc ctgcatcctc cagtacagaa 3123421 aggtgtttag ctatcgcctg tcgcgtaata gaaaggtcgt actttgtaat aagacgtatc 3123481 gtaagttcat acaacgtcag ctcgttgcgt tcagataatt cgtctaatat aagccgccga 3123541 gtcgaatcgc cgagtgcttt gaatatagcg tctttgttcc cattcatata ttgagtataa 3123601 gcaacccatt agttgcatgt caagtataag caactgtatg gttgcgtgat atagaaactg 3123661 aacctatccg gcgcaggtct gaaatattct aatcgataag gaattaaaac cattaaaata 3123721 acagtggata tgtctctgaa aaataaaaga agacgaactt caaaagttcg tcttctacaa 3123781 tcaaattcgg cacgccggcc attttaaagt tgataactat ctctaaaccc cttgataaac 3123841 aaaggagttt tcatcattaa ccgatagaac cttccatttc gaacttaatc aaacggttca 3123901 tttcaactgc gtattccatc ggaagctctt ttgtgaatgg ctcgataaag cccattacga 3123961 tcatttcagt tgcttcttct tcagaaatac cgcggctcat caagtagaag agctgctctt 3124021 cagatacttt agacactttc gcttcgtgct ccaatgaaat gttatcattt aagatttcat 3124081 tgtaaggaat tgtgtcagaa gttgatttgt tatccataat gagcgtatca cactcgatgt 3124141 tagagcgggc gccttccgct ttgcgtccga agtggacgat tccgcggtac gttacttttc 3124201 cgccctgttt tgaaatcgat tttgatacga ttgtagatga tgtgtttggt gcaaggtgaa 3124261 tcattttcgc acctgcatcc tgatgctggc ctttacccgc aagagcgata gaaagcgtca 3124321 taccgcgcgc gccttcgcct tttaggatac aagccggata tttcattgtc agcttagaac 3124381 cgatgttgcc gtcgatccat tccattgttg cgttttcttc acagactgta cgctttgtta 3124441 caaggttgta aacgttgttc gcccagtttt ggatcgttgt ataacggcag tagccgcctt 3124501 ttttcacgat gatctcaacg accgcactgt gaagtgagtt tgttgtgtaa acaggcgcag 3124561 tacagccttc aacataatga acgcttgctt cttcgtcaac aatgatcagt gtacgttcga 3124621 actgacccat gttctcagag ttgatacgga agtaagcttg tagcggtgtt tcaaccttca 3124681 cgcctttagg cacgtagatg aaagaaccgc cggaccaaac agctgagtta agcgccgcaa 3124741 acttgttatc agtcggcggg attacttttg cccagtgctc acggaaaata tcttcattct 3124801 ctttcagcgc gctgtcagtg tctttaaaga cgatgccttg tgcttcaaga tcttctttca 3124861 tgttgtggta tacaacctca gattcgtact gagcagaaac acccgcaagg tatttttgtt 3124921 cagcttcagg aataccgagc ttgtcgaatg tttgtttaat ttcttcagga acttcatccc 3124981 aagaacgctc tgaacgctca gacggtttta cgtagtacgt aatttcgtca aagttcagtg 3125041 agtttaaatc tccgccccat tgaggcatcg gcatattgta gaaatgctca agtgatttca 3125101 agcggaagtc aagcatccat tgaggctctt ctttcatgcg agaaatttct tctacgattt 3125161 cttttgtcaa tccgcgctct gaacggaaaa tggaaacgtc cttgtcgtga aaaccatact 3125221 tgtattcacc aatatcaggc atttttttag ccatccattt tcactccaat ccttttaatt 3125281 gccgccttct tctttcgcga ctcctttttc aagtgctttc catgacaggg ttgcacattt 3125341 gatacgggca gggaattttg aaacgccttg aagggcttca atatccccga gatctataga 3125401 atcatcatac tctttccctt gcatcatatc cgagaaaatc ttagacatgg aaagggcagt 3125461 ttcaatatct ttccctttaa tcgcctgagt catcatcgaa gcggatgcca ttgaaatgga 3125521 acagccttcc ccttcaaact tcgcatcttc cacgatgtct ccgtcaagct tcattgtcag 3125581 tctgatgcgg tcgccgcatg tcggattgtt catatccacg acaatgctgt catttaaaac 3125641 ccctttattt cgcgggtttt tgtaatgatc cataatcacc tgtctgtaca atgtatctaa 3125701 gtttgcatta aaagacattt gtaaaatact cctttgtctt ttgaagagct tccacaagct 3125761 tatcaatctc ttcctctgta ttatacagat aaaagcttgc tcttgcagta gcagttacat 3125821 ccagccattt catcagcggc tgcgcacaat ggtggccggc tctgactgcg attccctccg 3125881 catcaagcac agtcgccaca tcgtgcggat gaacatcatc aaggttaaat gtgacaagcc 3125941 cggcacgctc ttccggcccg taaaccgtta cgccgtcaag ctggcggaag cgttcaagcg 3126001 cataagctgc aagcttgtgc tcatggcggg aaatctcatc aagaccgatt tcttcgagaa 3126061 aatcaatggc ggcaccgagg ccgattgctc ctgcaataat cggcgtaccc gcttcgaatt 3126121 tccacggaag ctctttccaa gttgattcat aaagcccgac aaagtcgatc atttcaccgc 3126181 cgaattcggc aggctccatg ttttccagca gggctttctt tccgtacagc acaccaacac 3126241 cggtaggtcc gcacatttta tgggaagaaa gcgcaaagaa gtcgcaatcg agatcctgca 3126301 cgtcaatttt catgtgaggc gtgctttgtg caccgtccac cacaatgaca gccccattgt 3126361 catgagcgat tttcgccatt tctttaatcg ggttgaccgt gccgagaaca ttagatacat 3126421 gagacaccgc aacaattttt gtgttgcttg tgaccgtttc tctgacgtct tctaaagaaa 3126481 tcgttccgtc ttcctgcaac ggaatatatt ttaatgtggc gccagttgct tttacagcct 3126541 gctgccacgg aatgatattc gcatgatgct ccatgtaggt gatgaccact tcatcaccag 3126601 gtttcaggtt ggcgcgcgca tagcttaacg ccaccatatt cagtgatgtg gtcgtgcctt 3126661 ttgtgaaaat aatctcagcc attgacttcg cgttaataaa cttgcggact ttttcacgcg 3126721 ctccttcata accatctgtc gctctggttc caagtgtatg gacgccccgg tgaacattgg 3126781 aattgtattg gttataatac ttatccagtg tttcaatgac agcacgcggc ttctgggaag 3126841 tcgccgcgct gtcgagataa acgagatcat gtccgttcac ttgctgatga aggatcggga 3126901 actgttcacg aatatctgtg atattcatta cttcactttc ctttcgataa cagaaactaa 3126961 ttgtttctta acgccttcaa tcggaagttc atttactacc ggtgcaagga atccgtaaat 3127021 gactaagcgt tctgcttctt ctttcggaat tccgcggctc atcaggtagt aaagctgaat 3127081 agggtccaca cggccgacag atgccgcatg tcctgcagtt acatcgtctt cgtcaattaa 3127141 aagaataggg tttgcgtctc cgcgtgcttt ttcgctaagc atcagcacgc gtgattcttg 3127201 ctccgcattc gctttagaag cgccatgttc gattttgccg attccgttaa agatagaaga 3127261 agcggaatcc ttcatcacac cgtgcttcaa gatatagcct tcagaagctt taccgaaatg 3127321 gatgatttgt gttgtgaagt tttctgtttg ctctcctctt ccgacaacaa ccgttttcgt 3127381 atcgccgtat gtgccgtcac cgtaaaggtt tgttgtgttt tcggaaatcg tgtcgccatc 3127441 gttcatcagg ccgagagccc actcgatttt gctgtcgcgt ccgcgcgcag caccgcggcg 3127501 gttcacataa gttgtcacac cgcttgacag attatccacc gcaccgtatg tcacgctggc 3127561 attatcacct gtgatgacct cactgataat attgaagaca gcgtctttcg ggtttacagt 3127621 gctgatgtag ttttctacat atgttacaga gctgtggtct tcagccacaa tcagcacgtg 3127681 gttgaataga gctgtatcat tgctttcgtg gacataaaca gcctgaaccg gcgtctccac 3127741 ctgaacattt ttcggaacat aaaggaatgc tcctccgtta acaagagccg cgtgaagtgc 3127801 agttaactta tgttcgtcaa ccttcacgcc gtccttcata aagtatttct ccaccaagtc 3127861 gctgtgctcg cgtgcagcag tcagaatatc agtgaagatg acgcctttgt ctttcaattc 3127921 ttgagaaaga gaaagatgtg ccggcgtctg gtcacgctgt acgtataatg ttttatcttc 3127981 gttttcaatg tcgatcagcg cttttacttc atcagtcaaa tcttctaatg aagaaagcgg 3128041 ttcgttatcc actgtatgct tcgcgaaatt cgtgaagttc cagtttgtga tttttgtttt 3128101 gtcaggtttc ggcatcggca gatcctcagc ttgttcaaga gcctgtaagc gcaggttctt 3128161 cagccaggca ggttcttggt gcttttcgga aaagcttttg agatactcct gatctacgga 3128221 tagttttgta cctagtgtca tattaatccc cctaacgctt acgcttcttg gccaacagtt 3128281 tcgtcttcaa tgccaagttc ttgtttgatc cagtcataac cttctgcttc aagacgctgt 3128341 gcaagctctg caccgccgga ttttacaacg cggccttgca tcataacgtg aacaacatcc 3128401 ggagtgatgt agtttaacag gcgctgatag tgagtgatca tcaggcagcc gaagttttcg 3128461 ctgcgcattt tgttgatccc ttttgataca actttcaaag cgtcaatatc aaggcctgag 3128521 tcaatttcat caaggatggc gattttcggt tcaatcatca ttaattgaag gatttcgttg 3128581 cgttttttct ccccgcctga gaagccttcg ttaagatagc gctgagccat ttcagggtcc 3128641 atttcaagga actccatgtt ttcgtccatt ttgcggatga atttcatgag agaaatttca 3128701 tcgccttctt ctctgcgcgc gttgattgct gagcgaagga agtcggcatt tgtcacaccg 3128761 ctgatttcac ttgggtactg cattgcaagg aataagcctg cctgcgcacg ctcgtccact 3128821 tccatctcca gtacatcttt gccgtcaagc gtgatgctgc cttttgttac ttcatattta 3128881 ggatgcccca taatagcagc tgataaagtg gatttaccag ttccgttcgg gcccattact 3128941 gcgtggaatt ctccaccttt tatttcaagg tttacaccct ttaagatctc tttcccttcg 3129001 atttcaacgt gaagatcttt gatcgttaat gttgaagcag ccatatctat acctccaaaa 3129061 atatataatc attattctca ttttattctc attctaattt tataacaaat gaaaagtaaa 3129121 tacaactttt tatcgtgcct tgcacattcc tcaagtttaa caaagatcag cactttatta 3129181 aagcgattga aaaagaaaaa gagtggattc ccaccctttt ttaaaagatt gattttctca 3129241 ataagctccc gcagaaatcc gcttgctttt ttcataatca agctctctct gccgctctac 3129301 tttcattctt gtttccagcc ggcgtccata ttcctcgtat ccaattccgt gtgacagctg 3129361 catcgctttt tccatttctg acgtataatc gaggttcagt ctgtcctggc tgctgcaaat 3129421 aatgaatcaa tcccttcata tatttgcttt ttattgtacc agtgctgcgt tggatgccgc 3129481 aaaaacgatt tggcgtgaaa tagcggcaga tgagacgaaa gcatcctttc agaacaaatg 3129541 agaatggttt ttcggaatat tccttctctt aatgcgtggt gtttccgaat tcctcaatgc 3129601 actgttgaac gactgtcacg ccttggctga aagctgcgcc gcctccaaat gccgctgcca 3129661 cactgacggc ttcgagaatg ttttcttctg acgctccctg atcaagacag ccttttgtat 3129721 gatagatcat gcaatattcg tcctgagcat tgatggcaat tccgagggcg atcagctgtt 3129781 tttctctttc agtcagagaa ttcccggcaa agcactgttc agtaaattcg ttaaattttc 3129841 ttcccatcag cggcatcttt tgttcaaatg tgcctaaacc atgtttatat tgttttaacg 3129901 cgtcctgcat gcttcctctg tcttgattca aagaaaatcc ctccatctgt ttaacattcc 3129961 tttttattat gaacagcttt taggaaaata cgcgaaaaaa accccggaat tctcatccgg 3130021 ggtttcagtc ttattcagat acaggaagca cagctccgtc gtattttttc tcgatgaagt 3130081 ctttgatctt tttagagtga agaacttcca tcagcgcttt gatttttgca gaatcttctt 3130141 cgccttttct tactgcgatg atgttagcgt atgggttgtt tttcgttgat tctacttcaa 3130201 ttgcgtcttt tttaggattt aatttatttt ggatcgcata gtttacattg atgaagaccg 3130261 cgtctccttc tttgttttca tatgcttttg ccgttaattc aggcgctact tttttgaatt 3130321 caaggttttt cgggtttttc ttaatgtctt tcaatgttgc gtcaactgtt tccactttag 3130381 aatcaagagt gattaatcca gcgttttcaa gcattgcaag catacggcct tgttcagcaa 3130441 cgttgtttgt cagaatgatt gtcgcaccgt ctggaaggtc tttcagtgat ttgtatgttt 3130501 tagagtaaat accgaatggc tctaagtgaa cagcgccggc attcacaagt ttgtaatctg 3130561 tgttttcttt catttcttgc tcaaggtaag gaatgtgctg gaagtagttc gcgtccactt 3130621 ctttatcagc taaagcttta ttgtacattt tgtaatcact aagcactttc actttcagcg 3130681 tatagccttt ttctttcagc aatggttcag cttcttttaa aatttccgca tgcggtgttt 3130741 ttgttgccgc aacgacaatt tctttcttgc cggattcagc gccgttattc gaaccgcagg 3130801 cagccataac tcctgcaaat acaagcagta atgcacccaa aaatagcttt ttcaatgtaa 3130861 atcctccctt atcgtttgtc tataatattt gttattagat caccgatgat ttgaataata 3130921 aacacgatga ttaaaataaa cacagtagca acgaaggtaa catcagcgtt attagactga 3130981 tatccttcta cgtacgcaag gtttccaagg cctcctgaac caatggctcc ggcaattgcc 3131041 gttgaaccga ttaaagcgat ggctgtaacc gtaatgccag aaataagagc aggcattgat 3131101 tccggaatca gcactttgaa aataatcgta gacgttttcg cgcccattga tttagctgct 3131161 tcaatcacac ctttatccac ctcacgcagc gcgatttcaa caaggcgcgc gtaaaatggt 3131221 gccgagccga ttaccagcgc cggcaatgcg gcgtttggcc ctaagatcgt gccgactaaa 3131281 aatttcgtaa aacctaatag taaaataatt aaaataagga acggaatcga tctgaatatg 3131341 ttaacaacgg ctgcaatcac tgagttgacc gctttattct gccagaggct tcctttgctc 3131401 gtcagaaaga gcagcaagcc gaggatgacc ccgatgacaa aagcaaacag taaagaaatc 3131461 agcgtcatat aaagtgtttc atatgtcgcg ttccataatt cagttaaatc aacgttcggg 3131521 aagtattttt caaacattcg tgatcacctc tgctttcacc tgtttgtcat taatgaatcg 3131581 gatcacgttt tgcacttctt cctcgtcccc gtcaatgtgg atgaacagtg aaccgtaagc 3131641 cccatccttc gtctgcgaaa ttttcccttg cagaatattg acgctgacat tgaagtttct 3131701 gatcatctct gtaatcagag gctgttcagc tgactcaccg acaaatgtga gctgaaccat 3131761 ttttcctgat gctgtatcat caagaaggtg ctgaagcgtc tctttcgttt cttccggctc 3131821 tgtcacctgt tgaacaaatc gttttgtcat ttgttccttt ggatttttga agacatcgag 3131881 aacctcgcct tcttcgacca ccttgccgtt ttccatgacg gcgactctgt tgcagatttt 3131941 gcgtatgaca tgcatttcgt gcgtaatcag cacaatcgtc aaaccgagtc tttcattaat 3132001 atcggacaat agatccagaa ttgaatctgt cgtttgcgga tctaatgctg atgtcgcttc 3132061 gtcacaaaga agaaccttcg gattgtttgc aagcgctctg gcaattccga cacgctgctt 3132121 ctgaccgccg ctcagctggg acggataaga tttttctttt ccttctaaac ctaccagttt 3132181 aatcagttca ttggcgcgct tgatccgctc gctctttttc accccggcaa tttctaaagg 3132241 aaacatgata ttatctctga cagtccgcga ccaaagcaaa ttgaaatgct ggaaaatcat 3132301 actgatctca tggcgtgctt ttcttaaacc gcgtccattt acttcattaa tcttggttcc 3132361 cgccacttcc acggttcctg aggttggttt ctcaaggccg ttcagcagac ggattaagga 3132421 actcttacca gctccgctat atcctataat tccaaaaatc tcaccttttt taatggaaag 3132481 cgagacgttt tggacagcat tgacatctcc atgtttcgac ttgtaaactt ttgaaacatc 3132541 ctgaagattg atcaaagcaa tcacctgcct taacactatt ctaagaaatc ttccggtttt 3132601 ttctgcaaaa gaaaagcctt tctgcacact tgagcagaaa ggcttatata aaatgccttt 3132661 ctctcatctt tcaaagctga acgcttcgtg tgaattggca ccatttcaac agtgttgatg 3132721 gttgccgggc ttcatagggc acttccctcc acctctcttg ataagagaaa tatatagtct 3132781 ttttcgtccg gaaattctta atgtagaata gcacggcgaa tgattaaatg tcaataaaat 3132841 aaatgatgtc aacttttact attataataa tttattattt tttaattttt taaaatcctc 3132901 tgaaaaaatc catttgtcag ccagagaatg gcttccagct ttaacagggc cctgaatgac 3132961 ccctttactt tgaggcttcc gctctgaata aggtgctgaa gggaaatgtc tccgtgcaat 3133021 aaatcaataa tttccgtttg gtttccgtaa aaggtcaggt tggacgtttg gggcggagaa 3133081 acttttttca tttctccctg ttcgtttatt gagacggtta aggcttctgc ttctccttgg 3133141 aaggtaatga gcaatgttga ggcattcaaa aggggtttta aaaacagatg ctgatactca 3133201 tcttctaaaa cttccgcttt ctccatatgt acaacctcct atttgttggt catacataca 3133261 catttctctc tttgtcgcaa gaaccccttt ataaaacgaa cgacaatttc attggatatg 3133321 ctgagaaata tgtcataaat gggatgcgga agatgatttt tgtttgatca gctcatataa 3133381 ataagaaacg gaatgaaatg catatcctct ttcgaccatc tttccgcctt taaacagcag 3133441 aaaacaaggg acgctttcaa tttgatacgc ttttgcgaat gtcggagagt aattgacatt 3133501 gttttgatag aaggcgacat ccggcagcat ttctttcacc actgtcagca ttttgcttgc 3133561 aagctggcag gtgccgcaaa acggagtata taaatataga aggtacacat catcttcaat 3133621 gtgatcaagt tcgtgttctt ggagttcttt catgctatac acctcgggac tttctttcaa 3133681 gaaaaatagt atggacattc agattcgcac gcagcaatac agaagcgata tggtgcctgg 3133741 gcgcagccgc tacttcctta taggctctgt cgacatggag atggcaggct tcattaaatt 3133801 cacgcttcag ctgttttctc aatttctcac ctgattcatc agcatcaact aatatataga 3133861 cgtctttatc ataaagctcg tcagccaatt cctcgagcct cagctggctg attgttccgt 3133921 ttgtgcagat aatgcgcatc ggttcattca ggacgctttc gattttctct ttatctgatt 3133981 tcccctcgac aatcataacc ttttccagct catccatctt catcttgttc acctgccgcg 3134041 tcaaatttga aatgttcaga ttgtaaaaga aggcagtgaa attcaccgcc aacattaaca 3134101 ccagccgttt tcgtagtcac aatctacata ttttgcgtcg tctccagaga ccacatcggc 3134161 tgtcttataa aatttctcat tttcaaagga ataaccggac ttaagctcat attcattcat 3134221 gcttgtcatt tggccgatca tctcattatc atgatataac gagagccggc cattttgaaa 3134281 gcggcctgtc acgtcattgg tgacatcgag cttttgtttg tcgaaagcca tattggacac 3134341 ctcccataac gttagcgtgt ccaattgctt ttacggctat cctgttttag tcttcttgtg 3134401 tcatctcttc gtattgctct gctgtcatca gtttttcaat ttcagaagcg tcagatggct 3134461 caacgacgat catccatgct ttttcgtacg gagattcgtt gacgaattcc ggactgtcat 3134521 caagatcttc gtttacttcc acaaccgttc cgttaatcgg tgcataaagc tcagataccg 3134581 ttttaacgga ttcaacactg ccgaatggct cgtccgcttt gatttcagcg cccacttcag 3134641 gaagttcgac aaacacgatg tcgcctagtt cggactgggc aaaatgcgta attccgattc 3134701 tggctttttc tccttcaact tttacccact cgtgttctcc tgagtaacgc aaatcttttg 3134761 gtatgctcaa ttgaatccct ccatttttta cagcactaca ataagaagat accacacttt 3134821 tcaaaaaaaa tttacattaa gcccagtttt cttcaaattg gtcttcttta aatccgacag 3134881 tcactttttc gccgtctgtt gtaagcgggc gtttaattag cataccatct gaagccagca 3134941 gttcgagctg ttcgtcctct gacatatgat acagcttttc cttgagattg agctcgcggt 3135001 atttcatgcc gctcgtgttg aaaaatttct tgagatccag cccgcttttt tcataaagcg 3135061 cttttaattc ttctttgctt ggcggctgct cagcaatatg tatttcgttt atttctttcc 3135121 catgctcttc aagccacttc tttgctttgc ggcacgttcc gcatttaggg taccagtaaa 3135181 aagttaacga catcttcttc cccctcaata aaataatcga ggttatttta acacagtttg 3135241 ttttaaaaac ctaaaacagt gcttcttaaa aaagagctcc gcgcatgcgg agctcatggc 3135301 caatcagaca gtatatttct cagcctcaaa aatgcctgcc gccgcctcgc gttttttctg 3135361 aatcacgttt ttaggcgtta cgcgtgtcag cttgcgcaga gcggaaagca tcatgcggag 3135421 tgaatctcct tcttccattg cgataaggga ttcctttgca tgcgcttcga tttcgttaaa 3135481 ggcctcttga acgaaaattt ctgtgtacag caccttttgc gctgcttttt cagcgccttg 3135541 tgcggcaatg gccttttccg ttctgagcac ggctgattcc attgcgtata cattgctgac 3135601 gatatccgct acgttcacga gaatttcttg ctcacgatcg atcgcttttc cgtatttttg 3135661 cgcggctagg ccggcagcaa acaacgcaat ttttttggct tgcttgacga tatatttctc 3135721 ctgctctaag acgccgcttc caggctcttc aggcataagc atcatgagtt cttcctgcag 3135781 cgactgcgct ttttcgaata aaggcagctc gcctttaagc gcttttttca ggaaggtgct 3135841 tggcacgatt aaccggttga tttcgtttgt gccttcaaaa atccgattga tccttgaatc 3135901 cctataggcc ctttctactt cgtattcctg cataaagccg tagcctccat gaatctgcac 3135961 gccttcatca acgatataat caagcgtttc agagccgaat accttattca gagagcattc 3136021 gatggcgtat tccgcaatcg atttggcgat ttgccggccg tccttgagat cttcggccgt 3136081 gaactggctc atattgtctt caaacagccc gacggttctg tatacagagc tttccatcgc 3136141 atacagcctt gaggccattg tcccgatttt ttcctgtgtc aatgaaaaac cagcaatcgg 3136201 cgttttaaat tggcggcgct gatttgcgta tgccgcagac agctcgatga cgcgtttaga 3136261 tgcgccgatt gtgccaaccg ccagtttgta acggccgatg tttaaaatat taaaggcgat 3136321 gacatgccct ttgccgattt ctccgagcag gttttccttt ggcacttcag cttgatccag 3136381 aatgagggtt cttgtcgatg atcccttgat tcccattttc ttttcttccg gtcccgtgga 3136441 gacacccggg aactcttttt ctacaataaa ggctgaaaac ttgtcgccgt ctaccttagc 3136501 gtaaactaca aatacatcgg caaaagcaga gttggtaatc cactgttttt cccctgttaa 3136561 tacataatgg gttcctgctt cattcagcac agctgttgtt tttgctccaa gtgcatcaga 3136621 cccagagcca ggctcagtca gagcataagc ggcgatcttt tcgcctgaag cgagtccagg 3136681 caaatatttt ttcttttgtt cttctgaccc gaaaaagacg atcggcaagg aaccgatacc 3136741 gacatgcgcg ccataagaaa gagaaaagct tcccgcacgc gaaaatttct cagtgatgag 3136801 tgccgagctg attttatcaa ggccgagccc gccgtattct tccggcacat cggcgccaag 3136861 cagccctagt tcgcccgctt tcttcaacag tctgacagaa tgctcgaatt gatggttttc 3136921 gatatcatct atatgaggga gaacatcttg ctcgatgtaa tcctctgttg ttttcgcaat 3136981 cattttatgc tcgtcagtga aatcctccgg tgtatacatt tgatcgtatg tgacatcctc 3137041 gattaaaaat ccgccgcctt tttgtacgtc agccgctttt tttgccattt gtttttcccc 3137101 ctttagcata attcaaatac accggccgct cccattccgc cgccgataca catggtcacg 3137161 actccaaatt gctcgtttct ccgtttcatt tcatggatga gtgagagtgt aagctttgtg 3137221 cccgtacagc caagcgggtg tccaagcgcg attgcgcccc cgttgacatt cactttttct 3137281 tcatcaattc ccaattccct gattacttga atggcctgtg aggcaaaagc ttcattcagt 3137341 tcaaacaagc cgatgtcctg cagctgaagt ccggcaagct tcaaagcgcg cggaatcgct 3137401 tccaccggtc cgattcccat cacttccggc ggcacgccgc ctaccgcaaa ggagcggaat 3137461 ttcacaagcg gcgccaggcc aagagcatcg gctttttccc ggtccatcag catgacagcc 3137521 gccgctccgt cactcgtttg tgaggaattg cccgcagtca ccgtcccgtc aacggaaaag 3137581 gccgggcgca atgtcgataa gatgtctgca gtcgtttgcg ggcgaacacc ttcatcctga 3137641 gaaaacacaa actgtttttc cataggctta tggtcttctc cgatttctgt caccgtcact 3137701 tcgacgggta caatttcatc tttaaatttt ccttctgcaa gggctttagc ggcgttttga 3137761 tggctgcgaa cggcaaacgc gtcttgatcc tcacgggaga cgccgtattt tttcgcgact 3137821 tgctcggctg tgtgccccat gctcatataa tattccggtg ccttttctgc caaagcaagg 3137881 ttcggacggg taacatgccc catcatcgga acttgcgaca tggattctgc tccgccggcg 3137941 atcgctgtat cgtaggcgcc cagcataatt ttttctgctg catacgcaat agactgaagg 3138001 cctgaagagc aatagcggtt aactgtaatc gccggaaccg tgtacggcag gcccgcgagc 3138061 gcaccgatat ttctcgccat attaagcccc tgctccgctt caggtgttgc acagccgata 3138121 atcaagtcat caatattgcc ttcgtagccg cctgcccgtt tcagcgtttc ttttacacaa 3138181 atcgctccca aatcatccgg gcgaacggtg gccaacgatc ctttttttgc ttttccaacc 3138241 ggtgttcttg cacctgacac aatgactgcc tctttcataa gctccctcct aattccgtaa 3138301 aggtttacct ttcacaagca tatgctgcat tctcgcttga gattttgcct ctcctgacaa 3138361 actcaaaaac gcttctcttt cgatctccaa taaatactct tcatcaacct ctgtaccaaa 3138421 cggcactttt ccgcccgcaa tgacataagc gagttttttc gcgatcttaa aatcatgctc 3138481 agatatatag ccggacagct tcatctgctc agcgccaagc aagagtgccg cataaccggt 3138541 ttctcccggc accttgacct tttcttttac aggcggccgc cagccggtat cgtataaaga 3138601 tgcggccagc tgcttcgcat cgtataacag gtggtcttga ttcacgctga tctgatccgt 3138661 ttcttttaag atgttcatct cacgagcctc ttgagcggaa gcggacactt tcgccatcgc 3138721 gattgtttca aatgttttca ttgccgcatt catcggatca tggccgcggc gaagatggtt 3138781 gatgtacagc tctttgttac ctcctccgcc agggatgagg ccgacaccgg attccacaag 3138841 tcccatatag gcttcgcttg ccgcttgaat gcgcgccgcc ggcaggcatg cttccgttcc 3138901 tccgccgagc gtcatgccaa atggcgcggc gacgaccggt ttcgcactgt atttgatctt 3138961 catcatcgtc tcctgaaaac ggcggatcac aaaatcaact tccaaaaagt tgtcatcttg 3139021 gacttccatt aagatcatgg cgagattcgc gccgacgcag aaatttttcc cttgattgcc 3139081 gatgacaagc cccttgtaat tccgttctgt ttcctctaat cctttgtgga tcatttgaat 3139141 gatatcgagg ccgatcgcat tgcttttcga atgaaattca agaagggcca catcatctcc 3139201 aaggtcaatt aagcttgctc cgctgttttt cgcaatcacg ccttttgttt ctttaagtgc 3139261 ttgtaaatga attcgttttt tgttttcttt cacggctctg tattcgccgc ggtcataata 3139321 aaataccgtt ccgttctctt tgatgtagaa ggtttcattt cctttgtcca gcatctcttt 3139381 tatccagcca ggcatatctg ctccaagctg ctcaagcttt tccgctgact gcttgaggcc 3139441 gatggcgtcc cacatctcaa aaggtcccag ttcccagccg aatccccact tcatggcttg 3139501 gtcaatcgca tgaatatcat cggcaatctc gccaagcagc tcggctgagt aaagcagggt 3139561 ttgagaagtg atattccaca gcaaacggcc ggccctgtca tccgaataaa taagcgcttt 3139621 cattttggct tttgtccctt ttgcctgttt tgccgcttca agtgccggtg atttcatttt 3139681 tgtccgctcg ccgtaagtaa gcgtcactgg gtcaagctca taaatcgttt ttccttcttt 3139741 tttataaaag ccttggccgg ccttgcttcc gatccaccct ttttccagca tatcgttcat 3139801 gaagcttgga atgcgaaaca cttctttttc atcgccatca gctttgtcat acacatttcg 3139861 ggcaacgtgg gcgaatgtat cgaggccgac cacatcaagc gttctaaagg tggcgctttt 3139921 cggcctgccg atcagcggtc ctgtgatcga atcaacctcc ccgacctgat aaccgccttt 3139981 cagcatttct tggactgtca cgagaagccc gtaagtcccg atgcggtttg cgataaagtt 3140041 cggtgtgtcc tttgctgtaa caacgccttt cccgaggaca ttttctccga aagctgtcat 3140101 aaactttaaa atatcaggat ccgtttcctt aatcggaatg atctctagca gctttaaata 3140161 tcgtgcggga ttaaaaaaat gcgttccaag aaaatgggct ttaaaatcat ccgaccggcc 3140221 ttcagccatt tcctgcactg atatgccgga tgtgttgctt gagacgatgc ttccagtctt 3140281 tcgatgttca tccacaagag cgaaaatttt ctttttgact tcaaggtttt cgacaacgac 3140341 ctcaataatc caatctgctt ctttcagttt ttctgcatca tcctccagat tgccaggtgt 3140401 aatataggag gtatttttcg ctgatgtgag gggagcgggc ttttgtttca gcagtttttt 3140461 catcgcctgc cggctcagcc tgctgcgcac ctccgaactg tccttcgtca gccccttttt 3140521 ttcctcttcc tttgtcaaat cgttcggcac aatatctagc agcaggacag gaattccgat 3140581 gttagccaaa tgcgccgcta tcccggaacc cattaccccc gatcctaaaa cggctgcctt 3140641 ccgaatgtgt ttgtgcatga gatatccccc ttgaacattg aatgaatagt cattcatttt 3140701 ttgactaaaa aaaatgaaac ccgtttcttc tttcatctta aaagatttcc ggttcgactt 3140761 caatagctaa tttgttattt ttttgtatga agcctataaa agtcgggcaa cttaagcccg 3140821 gaggtgaagg gaatggtacg agagaaaaaa aatccgtctt cagcggcagt cagcgcggcg 3140881 agcgtaaagg gagatgccgg tccgactcag cattacggcg gcggaaaacg gacaagtcaa 3140941 aatcagcagt ataaaaaaca taacatggga caatcataat gcagctgctt cccacggctg 3141001 ctttcacttt ttcaaaattc cttttaacac aaacgctgca ttggcaggcc gttcggcaat 3141061 tcttctcata aagtagctga accagtccgt tccatatggg acatacacac gcattctgta 3141121 gccttccttg gcgagttcct tctgacgctc cggcctgatg ccgtatagca tttgaaactc 3141181 aaattgcgat gcggggattt gatgttcggc gacgagctgt ttcgtaaatg caatgatgtc 3141241 atcgtcatgt gtggcgacag ccgtgtagtt cccgcttaac aactgcagct ttattaagct 3141301 ctgaaaatga aggtccgtgc ctcttttgtc gggaaacgct acagccgcag attctttata 3141361 agcgcctttt acaagtctga gattcggctt taagtcccgc atctttctga tatcttctgc 3141421 cgcccggtac aaatacgcct gaatgaccgt gccgagcttc tcaaattcct gtttgcattg 3141481 cctgtaaata gaaagtgtct gttcataatg agaatagtct tccatatcaa tggtcacagc 3141541 aacatcatat tgcttcgcaa cggaaagaat ggcgcgcaaa tgagtaagag caagttcttc 3141601 tgaaagatcg agcccgattg aggtcagctt aagtgaaagc tctgaattca attgatgttc 3141661 ggcaatggct tgaatggctt tcttgcattc ctctgcgact tggtttgctt ctttttccga 3141721 agctgcatac tcgcctaaat aatcaattgt tgcacacaaa ccggatctgt ttagcctttt 3141781 gacggtctta accgccgatt caatcgtatc ccctgcgaca aaccttcgtg ctccaagccg 3141841 cgttccgtat gcttttgcga acttggtaag tgttttattt tgagataaga ataaaaacac 3141901 atgtctcaac atccgactcc ctcccgccgt catcttcaaa acacctgtat ataactccca 3141961 gtctgaagga aactataaaa tgaacagaaa ccaaaggagg atcacaatgg ataatcagca 3142021 gcaatctcaa atgccgcctt ccgttatttc gacaaaggat catttgtatc tcaatgacat 3142081 gctgaactgg aatttgctcg cgatgaaaaa agcgcatttc atggcgcagc agtgccagga 3142141 tcaaacgtta aagcaagaac tcgaccgcgt cggacacatg catcatgatc actatcaaag 3142201 aatattaaag cacctgcagc caggccagca gcagtccggc tacatccaat aaggaggcgc 3142261 cagaatgaat cagcaaaatc aaaaaatcag caacccgcag acacctgtac cgacaacatc 3142321 ggaaatgaat gacagagatt tcgtcaacga attgctgaca accgaaaaat acatgacaac 3142381 agcttattgc actgccttgc acgaattcag ccacgagtct ctttatcagg atattcaatc 3142441 catttttgat gagtcacaaa aagcgcaaag aaaactatat gatctcatgt tccaatatgg 3142501 atggtattct gttgaagcgg aggattcaca aaagctgcag cagtcctatc aaaaattcca 3142561 gcagaccatt cagcagcagt ctccttatca gcaataacaa cattagtaaa aaggatacga 3142621 tgttctttcg ggcatctatc ctttttttgt gtaaaatcag ttgacttttc atttacgctt 3142681 atttatattt aataagcatt aactattttg tcattaaaat atatatacag tgtatgtaac 3142741 agaggggaaa tgaatatgaa gagtgcggat cagttaatgt ccgatattca attatcgctt 3142801 caggcgctct ttcaaaagat acagcctgaa atgctggaaa gcatggagaa acaaggtgtc 3142861 accccagcgc agctgtttgt gctggccagc ctaaagaaac acggcagcct caaagtttct 3142921 gaaattgccg agcgtatgga ggtgaagcca agcgcggtga cgctgatggc agatcgcctt 3142981 gaacaaaaaa atcttatcgc cagaacacac aacacaaaag acaggcgagt gattgatctc 3143041 agtcttactg acgaaggaga cataaagttc gaggaggttt tggcgggcag aaaagccata 3143101 atggcgcgct atctttcctt tttgacggag gaggaaatgc tgcaggcggc gcatattaca 3143161 gcaaaactcg cacaagcagc agaaacggat gaaaagcaaa acatgaaaag aggaaacgga 3143221 tgaaaatgag taaagaaggc aaacaatcaa aacgaacgtt attaataaca ggcttaatta 3143281 ttgccatgtt tttttcagcc cttgacggta ccattgtcgg aacggccatg ccgaaaattg 3143341 tcggtgatct gggcggtttg agcatgatga cctggctgac aactgcatat ttgttaacat 3143401 caacaaccat tgttccaatt gccggtaaac tggctgattt attgggacgc cgcattgtct 3143461 atgtatcagg tttgattatt tttatggccg cttctgcttt gtgcggaatg gccaacaaca 3143521 tgacggaatt gattatcttc cgtggactgc agggcatcgg cggaggcatc atgatgccga 3143581 tggcgatgat tgtcatcggt gacttgttca caggaaaaca gcgtgctaaa ttccaaggtg 3143641 tctttggcgc aatttacggg ctggcttcag tgattgggcc gcaaatcggc ggctggattg 3143701 tagactcgtt aaactggaaa tgggttttct atattaacct gccagtcgga attattgcgg 3143761 ttatttttat tgccagggga ttacagggac gccagcagac tggtccgatc aacttcgata 3143821 tcgctggtat tttcacaatg attgtcggtg tggtcagcct cctgctcgcc ttaagctttg 3143881 gcggaaaaga ttatgcatgg gattcatggc agattcttgg gttgttcgct ctcgcactga 3143941 tcggcattgt cagctttatc atcgtagaat caaaagcaaa agagccaatc ctgccaatgt 3144001 atttatttaa aaacagaaca tttacatttc taaacttgat cggcttcttt atgagtatcg 3144061 gtatgtttgg cgccattacg tttgttcctt tctttatgca gggaattgtc ggtgtaagtg 3144121 cgtctgaatc gggtacaatt atgacaccga tgatgatttc tatgattatc acaagtatca 3144181 tcggcggaca gcttgtttat aaaattggga ttaaaccgca aatcattaca ggcatgctgg 3144241 ttatggccgg cggattcctg ctgttaacga cattggatct cgacacgagc aagcttgtcg 3144301 ctacatcttt tatggcgatt attggtctgg gaatgggtct tgttatgccg attctgacat 3144361 tggctttaca ggaaagcttt tcgaaggagg agcttggagt tgtcacttca tccagccaat 3144421 tcttccgttc tatcggcgga acattcggca ttaccatgct gggagccgta atgaatgcga 3144481 gatcaggaaa tctattaaca gataaattgg ttccatattt agactctctt ccggcacagg 3144541 caagctcgtt tgccgcccag ctaaagggta tgattgatac aaatccgcaa gggctgctgc 3144601 aatcactgtt cagtccggac gcggtcaaac aaatccctgc ggctttctca tcccatattg 3144661 tgccgatttt aaaaacatcg ttgatggatt cgctccacag cgtgttttat acgggcctga 3144721 tctttatcgc agtcggagcc gtattcacct tgttcttaaa acctatcaag ctatcaaata 3144781 agaaagcgga agaccaacaa gaaaaagaga aggcggcaaa agccgttgaa tcaccttccc 3144841 attaatagag caccccgcgg gtatcaatcc gcggggtttt ttattcaatc atctgggctc 3144901 ttccatttcc gaaagaccaa tcctcatcct gatttccggc cagcatgata aacacatctt 3144961 cttttcttac accaagctcg gaatgaatcc ggctcgcgat tgagcggtaa agtgcttttt 3145021 tctgttcagt tgttcttgac tgtttcagtg taaaatgaat gtatatcagt tcatcagtac 3145081 gctcgacttg gagataaaat ggatcataaa aaaattcgct tttttcatat tgtctgatga 3145141 cttggaaata gtcatcttcc ggcacattga tttcttcaat catcgattgg tggatagtcc 3145201 tgctcagttt ttgaagccac acttcgcttc ttcccgaccg taaatgaatc tgtacaaatg 3145261 gcatctcccc gcatcccttt ctttacagcg tctgtccgct gtcaattgtg ataatttggc 3145321 ctgtgagtga ttcctgttca attagtgaac aaatcaattt ggcaacatca tctggttcag 3145381 caatacactg cagcagcaaa gagccgatca tgcttttcat tttttcttcc cgtccggccc 3145441 accatctcgt tgccacagct cctggtgcta caccgctcac tctgatttca ggcgctaagg 3145501 cgtgggccaa tgatttcgtt aaaccgtgca ccgctgattt tgatactgcg taaggcattg 3145561 atgagccggc accagttatc cctgcgatgc tgccgacgtt tacgatcgcc ccgtccttgc 3145621 ttttcttcat gaacggaacc actgcccgcg cgcagaaaaa catccctttc acattgacgg 3145681 catacagctc atcctagacg tcttctgtcg cagcctcaag atcatccatt ggaatatgcc 3145741 gtgtaatgct ggcattgttg actaaaatat caaccgtgcc gtgtgtgttc acgattgctt 3145801 gaatcatatc ctgcacgtcg ctgtttttgg atacatctgc ttggatggcg aaggcttgcc 3145861 cgccagcttt ttgaatcatt tccactgttt cctccgcttc tgattgcgag cgtgaataat 3145921 tcaccgccac aatcgcccca cgctttgcca attccatact ggctgctttt ccgattcctg 3145981 tgccgccccc cgttacgaga gctattttgt tcaagacatt cattgccgcc actccttgct 3146041 gttgactaaa gtatatttct gattccattg taatccagct ttgatgttac gtataatgat 3146101 tgttaaagat actagatatc actcagattg atagtaaacg aacggaggag ttcaaaatgg 3146161 aaagcggaga tttacgtgtg tttcaaatgg tagctcgtga agggaccatt acgaaagcag 3146221 ccctgcagct tggctatgta caatcgaatg tcacggccag aattcaacaa ttggaagctg 3146281 agctgggtac cacactgttt ttgcgccata atcggggcat gacactttct gcaagcggaa 3146341 aattgctgct ggactacgca aataaaatta taggccttct tgatgaagcg tctaaagcgc 3146401 tctcatcctc cgcagaacca agcgggccgc ttatgatcgg ctgcactcag acaaccgccg 3146461 cggtaaggct tccaaagctt ctggcatctt attatgaaga acatccaaac gtccagctgt 3146521 ctttaacaac aggacatacg caatttctcc ttgataaagt tcttcgttat gaattggatg 3146581 gcgcgtttat cggatgcgaa tgccatcatc ctgagctcga atcctatcct gcgtttgagg 3146641 aagaaccagt agttgtttcg gctgcctccg tgcccgatgt tgaggaagcc atcacaaagc 3146701 cgattctcgt ttacagcaca ggctgttcgt atcgagaaac acttgaaaaa tggctgcgtt 3146761 ccgtcggtgt cacacagccg gtcattatgg aatttgggac gcttgaagca attatcggcg 3146821 gggttacagc aggtcttggc atctcgttgc tgccaagaac ggttgtgcag aaacatgaag 3146881 cagaaggatc aattcgattg tacccgctgc ctgaagctct cagccagatg aaaacagagt 3146941 ttattgttcg aaaagattcg tttatcagca gcgcgctgag aacctttatg gattccttta 3147001 cgccagttaa aacggctgaa tcacaaaaaa gcagtctgct ataatgaaca gactgctttt 3147061 tggctattgt ttgtttcgat gcgcttcatt taattcctta atatgctgaa tgatctcttt 3147121 aatgccctgc ttcgcgtcgg ggtatgtcgc attccaatgc ttagcgagcg gaggcatgct 3147181 tttggctata tgggtgtaca aaatccattg cttcacttct tcttttagct catcgtttgt 3147241 ttcaccaagc agaagctcag tatacttctc cagcaatcca tcaagctgct cctgaagttt 3147301 ttgttccatt ttccatcttc ctttcgaaaa aacagcaagg agctttctca attgaaagct 3147361 ccttcgctgc gttatttatc catgtgatgt gaaagccgct tcctggacaa tgcatctgcc 3147421 cctgccatga ggaatgcaaa gaggcgttcc gaagagcggg tcctgtgtaa cctgacagtt 3147481 catagaaaac acattttgca caagatcaca agtgatgacc tcttccggac ggccttctgc 3147541 ataaatccgt ttatctttta tggccacaag atgatgcgca tagcggcacg ccaagtttaa 3147601 gtcatggaga accataacaa tcgtccggtc ttccttttca ttcagctcaa acagcaaatc 3147661 aagaatttca atttgatgcg tcatgtctaa atacgtcgtc ggctcgtcaa gaaggatgat 3147721 atccgtttcc tgggcaagcg tcatcgcgat ccaagcccgc tggcgctgtc cgcctgacaa 3147781 agaatcaacg gcacggtcag ccatgtcctc aagctttgtt gctttaagcg ctctttcaac 3147841 tgcttcctca tcctcttttg accactgctt cagccagttt tggtaaggat atcttccttg 3147901 cttcaccagc tgatgcaccg tcagcccctc tggagccgaa ggaccttggg gcaggattgc 3147961 gagctctttt gcgacttcct tcgtcggaag cttggcaatc gctcttcctt ccagcagcac 3148021 tgaaccgcct ctcggcttca tcaggcgcgc taatgaacgt aaaagtgtcg attttccgca 3148081 gccattgctg ccaataaata cggtaatttc acctttggga attgttaaat tcaactcatc 3148141 aataataacg gcatccccgt atcctaagct cagcgtttct gtagaaattg cactcatacc 3148201 cataaccgct cctttttgct ggctttttag cagcactatg tattgcacgt tttctatata 3148261 catgctttta agtcaattgt catcaatgca aatgattccg atattcagcc atttgatatg 3148321 gtcatatatc cctcattgta gcagaaaaca ctgactttga aaatcatttt caattagttt 3148381 tatggacata attgacgttt atgggttttt tatcacaaga ttacttcttg atttctctga 3148441 tggagccgtc cttcagcttc aattttaaat cgatatgatc ataatgactg tccagattaa 3148501 atgctgccag cacactgtgt atcacttctg tttcagccat ttggtctgtc acggaaagct 3148561 cgctcaaaat cattttcatc tcatctaacg cttcttctcc ttcctgattg acaccggaga 3148621 gcttatcctg tatttccgct ttttcctgag tcccgttctt tgtatagatt ccttcataac 3148681 ggttatgctc accatccccg tagctcacac gaagcgaaaa attactgtag ggaacggact 3148741 tcagctgggt gacggctgta ttttctcctt ctgcctgatg ctggtcttca ttgaaacggc 3148801 agcccgcaat cagaaccact gcgagacata cagccccggc tgctctgatc aaatgcatat 3148861 gtttcccccc tgtaggattc catttatttt aggtatatcc agagaatgaa atcctcattc 3148921 agagaagaat tgaaaaagcc ggggcattta acgccacggc tttttcttta agattcggtc 3148981 atttgtaaaa aggtttcggc gtcacgcaca gccagcttga tggcattctc ccagaaatcg 3149041 cgctttgtga tgtcagcgcc caaatgcttc atcgccaaat cctccactgt catagaagcc 3149101 gtatcgcgca atagcgccat atacttctct tcgaatgtgt ctttttcttc aagcgccaac 3149161 gcgtaaatac caagagaaaa caggtagccg aatgtataag ggaaattgta aaacggcacc 3149221 ctcgtgatgt gaaaatgaag ctttgatgcc caaaaaagcg gatgatattc ttctaacgca 3149281 ttgcagtatg cctctctttg cgcctcttcc atcagctcat tcaagcggct ggccggtacc 3149341 actccccgct ttcgttcctc gtagaatctc gtttcaaata gaaatcttgc gtgaatgttc 3149401 atgaagaacg caacgcttct ttgcacttta tcctccagaa gaacaagctt ttcttccctc 3149461 gtctcggcct gctggacagt cgcgtccgcc actatcatct ctgcaaacgt tgaagctgtt 3149521 tctgcaacgt tcatggcgta ggaacggttt aacggcctga cgttgagcat tgcttcctga 3149581 tggaacgcgt gcccgagttc atgcgcaagg gtagagacat ttgaggcgct tcccgaaaat 3149641 gtcatgaaaa tccgggattc cccgctgtcc ggaaaactgg tgcaaaagcc gccgactctt 3149701 tttccgctcc tgtcttccgc ctcaatccag ccgtcccgaa acgctttttc agtgaatgag 3149761 gacagctttt tgccaaacgt tgaaaactgg ctggtaatga tatttgcggc ttcatcatac 3149821 gaatagacct ttccgtcaga accgatcggt gcctcgacat cgtaccagct gagtttttca 3149881 aggccgagca tggatgcttt ccggttcaaa aactgaacga acggcttctt gttttcagtg 3149941 atgacctgcc acatcgtatc aagtgtttct tttttcatcc tgttaatttg cagcggttcc 3150001 ttcaggacat tctcccagcc gcgcgcttta taggtttcaa gccggaatcc cgccaaatga 3150061 ttcagcgtgc tgctgaaaat atcttgcttg ctctcccaag cttggcggaa acgttcatat 3150121 actgtttttc tgacagtacg gtcttgatga tccatcatat tctccgcctg accgacagac 3150181 aattgcttgt tttcaccgtt ttcctcatac gggatcgtca ttttcccgac aaccatattg 3150241 tataagtcac tccaagcgtg atatccgtcc accgcaaggt ttccgatcag tttttcctta 3150301 ccggggctaa gcttttcggc aaccctctgt cttctttcat ttaatatgta agaaacatcg 3150361 cgcaatcccg gttttgttaa caattcattc cacacgtctt gattaatgtc cacaagttta 3150421 tgatctaatg taacgagcga cgattgaaaa tctgcggaaa gccgattcat gaggcctgat 3150481 gctctatagc cttttgatca ttgatattct gggcctggag gcaagcaaca aaagcgccgg 3150541 cctgctgaag cttgacggat gtctgttcga ataaatcaag caacgcggtc agcccttcag 3150601 cctcttcagg cgattcaggc acctgaaacg catcagtcct gtcttgaaat gcacgcagac 3150661 tttgtgacag cttctcaata taacctttga attcttccga ttggctcccg cccttaaaaa 3150721 atgaatcaag atcccatctt tggcctaccc cttgcagcgc catatcacaa aacccctttc 3150781 cttctttcgt tctattatag aacaattctg aattattgta taaaaatttc tattacaggc 3150841 gtcatttcgt gttcaggata gtacaatagc tgtagcagtt taataggagg gttaggatga 3150901 ataaaaaaat agccatcgtg acaggagcgt ccagcggctt cggtctgctg gcagctgtaa 3150961 agcttgcccg atcatttttc gtgatagcca catcaagaca gcctgaaaaa gcggaacagc 3151021 ttcgagaatt ggctgcagca cacaatgtgt ctgattctat tcacattaca gctctcgatg 3151081 tcaccgatga acaatctata gtctcattcg gaaaagctgt tagtgcttac gccccgatcg 3151141 atttactcgt taacaacgcc ggaacggctt atggaggatt tatcgaggat gtgccgatgg 3151201 aacatttcag acaacaattt gaaacgaatg tcttcggtgt gatccatgtg acaaaaaccg 3151261 tgctgcctta cataagaaag catggcggcg caaagattat aaacgtgagc agcatcagcg 3151321 gactgacagg attcccagcg ctgtcgccat atgtttcttc caagcatgca ttggaaggtt 3151381 tttctgaaag cctgcgtatc gagctgcttc cgttcggtat cgaaaccgct ttgatcgagc 3151441 cgggctcata caagacatcg atctggtcaa cgtcattatc aaattttatg tcggtgcctg 3151501 ctgacgattc agcctatcat caatactata aaaagatcct ttcctatgtt caaaaaaacg 3151561 gagaagaaag cggagatccc caagaggttg ccgacctcat ttatcaattg gcaacaaaac 3151621 agcacataaa gaatttgcga tacccgatcg gaaagggcat caagctcacc ctgctgttcc 3151681 gatcgctttt tccttggtct gcgtgggagt ctatcctgaa gaaaaagcta ttcagctgat 3151741 ctaaattata attattataa tttagtattg atttttattt agtatatgat ataattaagt 3151801 caacagatca caaggaggac gttatcttat gaaaactgaa aacgcaaaaa caaatcaaac 3151861 attagttgag aattcactga acacacaatt atcaaactgg tttcttttat actctaagct 3151921 ccaccgtttc cattggtatg tgaaagggcc tcatttcttt acattgcacg agaaatttga 3151981 agaactttat gaccatgcgg ctgaaacagt ggataccatc gctgagcgcc tgctggcgat 3152041 tggcggacag cctgttgcca cagtgaaaga atacactgag catgcatcta tcacagacgg 3152101 cggaaacgaa acatcagcat cagaaatggt acaagcattg gtaaacgact acaaacaaat 3152161 cagcagcgaa tctaaattcg tgatcggcct ggctgaagaa aatcaagaca atgcgacagc 3152221 ggacttgttt gtcggattaa ttgaagaagt tgaaaaacaa gtgtggatgc tttcctctta 3152281 tttagggtaa caaaaaagct gaaccttaat cgggttcagc tttttgtttt ttcttagctt 3152341 gaactgcttt ctgtctgctt ggtcagtgtt gcgttcaacg ttttcgtttt tccctttcgc 3152401 agcacttgga ttgttgtttt atctccgact tttaagtctt tgtaaaggat ctgacggata 3152461 tccgcactgc tttccacgtc tttaccgttt agtttgacaa tgacatcctc agatttaata 3152521 cctgcttttt ctgccggcga atttgcttga acttctttta cataaacacc tttgcccaat 3152581 tgatctccaa acaggccgag cgtattttcc tgataggttt caggaacttg tgacatgtca 3152641 atcatctgca cgcctaaaaa cggacggtcc accttcccgt tttgcagcag ctggtcaaca 3152701 atcggctcga catcattgct tgggatcgca aatccaagtg attccacgcc gctttcgctc 3152761 accttcaagc tgttgatgcc gatgacctgg ccgcttgcat tgattaatgg gcctccgctg 3152821 ttccccggat tgatcgctgc atcggtttgc agcacgttca tttccaccgt cccctgtgtt 3152881 gtatccacat caattgtccg gttcagtccg ctaatgatac cttgtgtcac tgtaccggaa 3152941 aactgctgtc cgagcgggtt accgatagcg attacctttt cgccagtgcg cagctgtgaa 3153001 gagtcaccaa agctcgccac tttttttaca ttcttgccgc tgatttccaa aactgccaaa 3153061 tcagtaatgg tatcgctgcc gacaagcttg gcagtttccg tttctccgtt gtatagcgta 3153121 acagtcagct tgttcgcgcc ttcaacgaca tggttgtttg taatgatata cgctttatcg 3153181 ctgtcttttt tgaaaataac acctgacccg gttccgcttt cactttctga gctggagcct 3153241 cctcccgtgc cgaatgtgtt attttgagag gtttggatat ttgagattcc gacaatcgta 3153301 ggctctaaat cctctaccat atcagcgatg tttgatgcgt tcgttatcgg cgccgttgta 3153361 aaattatcag actgcacctg tttatttgcg gaagcggttt cggtcgcctg attttggtct 3153421 gacggcagat aaggcgcgat gccaagcatg aggcccccgc cgataatacc gcctaaaatc 3153481 gggctcagcc atgcggctct ccgtttcttt tcttttttca cagccgtttc ttgcttttcc 3153541 atttctaaag cagaagccgt ttcctgccgt cccgcttcat acgacacagg cgcgtcaagc 3153601 aattcttgtt cagaatgtcc aatcagcttc tggttttctg tattctgctg ttctgtatgt 3153661 gaaggttcag tttgatgttg atcgttttgg ccatcacgtc gataatccat gttcttacac 3153721 tcctttaacg gttattcatt tatcgttaca tattcatcgc atgtacaagt tcaattgtcc 3153781 caataatgag gagaaaagca aagcaccaaa atagaatatg tttgatcatc ctacatcttc 3153841 ctcgctcttt ttctcttcct ttcttccctt aaccatatca taaacaaaca ttgtgggata 3153901 aaaatgaaaa gaatatgtga aattatgaaa attgcctgcc gtatgttaaa actagtttat 3153961 aatgacgttg aaaggatgtg aagagccttg tcatacacca tttatctagt tgaagatgag 3154021 gataacctga atgaactgct gacgaagtat ttagagaatg agggctggaa cattacatct 3154081 tttacgaaag gtgaagacgc cagaaagaaa atgacaccgt ctccccacct atggattctc 3154141 gatatcatgc tgccggatac cgacggctat acattaataa aagaaatcaa ggcgaaagat 3154201 cctgacgtgc cggtcatttt tatttccgcc cgagatgcgg atattgacag agtgcttggc 3154261 ttagagcttg gcagcaatga ctacatttca aagccgtttt tgccgcggga gctgattatc 3154321 cgtgtgcaaa agctgctgca gctcgtatat aaggaagctc ctcctgtcca aaaaaatgaa 3154381 attgccgtct cctcgtatcg ggtcgctgaa gacgcccgcg aggtctatga cgaaaacggg 3154441 aatatcatca atttgacgtc aaaggaattt gatctgctgc tattatttat ccatcataaa 3154501 gggcatccat actctcgtga ggatatcctc ctaaaagtgt ggggacatga ctacttcgga 3154561 acagaccggg tcgttgatga tctcgtccgg agactgcgca gaaagatgcc tgaattgaag 3154621 gtggagacga tttacggttt cggctacagg atgatgtcat catgaaaaac aagccgctcg 3154681 cgtttcagat atgggttgtc atatccggca tcctgttagc gatatcgatt ttactgcttg 3154741 tgttattttc aaacacgctg cgagattttt tcactaatga aacgtatacg acgattgaaa 3154801 atgagcagca tgttctgaca gagtaccgcc tgccaggttc gattgaaagg cgctattaca 3154861 gcgaggaagc gacggcgccg acaactgtcc gctccgtaca gcacgtgctc cttcctgaaa 3154921 atgaagaggc ttcttcagac aaggatttaa gcattctgtc atcttcattt atccacaagg 3154981 tgtacaagct ggctgataag caggaagcta aaaagaaacg ttacagcgcc gacgtcaatg 3155041 gagagaaagt gttttttgtc attaaaaagg gactttccgt caatggacaa tcagcgatga 3155101 tgctctctta cgcgcttgat tcttatcggg acgatttggc ctataccttg ttcaaacagc 3155161 ttctgtttat tatagctgtc gtcattttat taagctggat tccggctatt tggcttgcaa 3155221 agtatttatc aaggcctctt gtatcatttg aaaaacacgt caaacggatt tctgaacagg 3155281 attgggatga cccagtaaaa gtggaccgga aagatgaaat cggcaaattg ggccatacca 3155341 tcgaagagat gcgccaaaag cttgtgcaaa aggatgaaac agaaagaact ctattgcaaa 3155401 atatctctca tgatttaaaa acgccggtca tggtcatcag aggctataca caatcaatta 3155461 aagacgggat ttttcctaaa ggagaccttg aaaacactgt agatgttatt gaatgcgaag 3155521 ctcttaagct ggagaaaaaa ataaaggatt tattatattt aacgaagctg gattatttag 3155581 cgaagcaaaa agtgcagcac gacatgttca gtattgtgga agtgacagaa gaagtcatcg 3155641 aacgattgaa gtgggcgcgg aaagaactat cgtgggaaat tgatgtagaa gaggatattt 3155701 tgatgccggg cgatccggag caatggaaca aactcctcga aaacattttg gaaaatcaaa 3155761 tccgctatgc tgagacaaaa atagaaatca gcatgaaaca agatgatcga aatatcgtga 3155821 tcaccattaa aaatgacggt ccgcatattg aagatgagat gctctccagc ctctatgagc 3155881 cttttaataa agggaagaaa ggcgaattcg gcattggtct aagcatcgta aaacgaattt 3155941 taactcttca taaggcatct atctcaattg aaaatgacaa aacgggtgta acataccgca 3156001 tagcagtgcc aaaatagact gtagatgttt tgcagtctat ttttttatgt gaaagaatag 3156061 ccgttaaaat ctctgtaatt tgttttgagc ggctgtttgc attgatgaac ccattttttc 3156121 tctgacaagg tctgcttcgg atatttgact ttctccactt tgattcctct gtttcgcaag 3156181 cggctgatca tttcgtccaa ttctctcatt ctagattcac cctttcgctt gagctttgac 3156241 cattcggtca tctcaattta taatataaat aatacatgat aaaaaaacaa gttacaataa 3156301 ggttaatttt ataacagacg gtgtgactat atggtcatat cctagcaggc ctccgggctc 3156361 cgaaagggtg gaaccattga aggaaaaaga aaaactgatt attgaaacag ccttaaaact 3156421 atttgcccaa aaaggataca actcaacatc agtccaggaa atcgcaaaag aatgcaaaat 3156481 atctaaaggc gctttttata tttattttcc ttcgaaagaa gcgcttcttc tctctatgct 3156541 gaactactat tatgataaaa cgtttacccg aattttaaat attaaaacga agggcgacag 3156601 ccccagaacg gcttaccgta aacagctgac cgtcctctat gaaaacattc ttgaacacaa 3156661 agattttatc agcatgcagt tgaaggaggg ttctctgcct tacacagaag aagtggagca 3156721 atgcgcaaaa aaaatccgcc agtcctcact tcaatttcat atcgacagcc tgctgaacat 3156781 ctatggaaaa aaagcggaac cgtacactgc tgagctttgt tttttaatag agggcatcag 3156841 ccagatttac ctggaatgca tgattttgct cgggtacact gtgaagccgt ctcaattagc 3156901 tgatatcatt atgaatcgaa ttgatgatat ggtaaaaggc atgtctgaac gaaacgataa 3156961 gcctttcatc acattggaag aggcgagctc tttattcgga cctcttacgc acggacggcc 3157021 tgacccgctg actgaatcaa ttgtgaaaag cctacgtgac aaaattaaca gcttaaacac 3157081 aaactcctct cttgaattat cggagagctt ggacatactt gaagcagaaa tgaagaaaaa 3157141 aacaccgaag ctggcgatca taaaaggaat gattcataat ctgacggagt ctgaagctct 3157201 cgccaaagat gcggaacagc ttaaatattt attaaaacag caacatattt agaagaacgg 3157261 ctgcttaaaa agcagccgtt cttcctatta cgcctttggt tttaccatgt cttccggctt 3157321 aaccatttcg ttaaattgct cctctgtcag caattcaagc ttcaaagctg cttctttgag 3157381 cgtcaatccc tctttatggg caagcttggc gattttcgcc gcgttttcat aaccgatatg 3157441 cgggttcagc gccgtaacaa gcattaatga atttgacagg ttttcctgaa tggtttcttt 3157501 attaggctca ataccgacag cacatttatc atggaatgaa ttcatgccgt cactgagcag 3157561 ctgcacagat tgcaggaagt tgtaaataat aacaggctta aacacgttca gttcaaagtt 3157621 cccctgactc gccgcaaagc cgattgtcgc atcgttcccc atgatttgcg ctgcgatcat 3157681 tgttaacgct tcgctttgtg tcggattgac tttaccaggc ataatagagc ttcccggctc 3157741 attttcagga atgacgatct ccccgatgcc gcagcggggt ccgcttgcga gccatctgac 3157801 atcgttcgcg attttcatta agtcagccgc aagcgctttt aatgcgccat gcgcataagt 3157861 gatttcgtca tggcttgtca gcgcgtggaa tttattcggc gagctgctga acgtttggcc 3157921 ggtcagctta gtgatctctt ctgagacaag ctctccaaac tctgggtggg cgttgatacc 3157981 cgttccgaca gccgttccac caattgcaag cgcacgcatt ttatctgtcg cttccaaaat 3158041 catttccttc gaacggtcca gcatgtgaac ccatccgctg atttcctgtc cgagggtcag 3158101 tggcgtagca tcctgaagat gcgtgcgtcc gattttgaca atatcattgt atgcttttgc 3158161 tttttcatcc agtgtattgc gaagctgatc aagcgccggc acaagctgct cgtaaacagc 3158221 caaaacagcg gcaacatgca tcgcagtcgg gaatgtgtcg tttgagcttt ggcttcggtt 3158281 cacgtcatca tttggatgaa tcgtttgatc agagttcttc tcttttaata aagcagtcgc 3158341 acggttggct accacttcgt tcatgttcat attgctttgt gtgccgcttc cggtctgcca 3158401 tacgacaagc gggaagttgt catcgtactt gcctttgagc acatcatcac aaaccgctgc 3158461 aatcgcttct gctttttcag cgtccagatt gccgaggcgt ttattagcta gagcagtgct 3158521 tcgttttaaa attgcaaacg ccttcacaac acgcatcggc attttttcag aaccgatctt 3158581 aaagttctcc ttgcttcgct gtgtttgggc gccccaaaat ttatcagcag gaacttttac 3158641 ttctcccatg gtgtctcgtt caattctgta ttccatttat gtatccctcc ataacggttg 3158701 cttcaataga tcataattcg ccaatgacac aaaaaatcct ttttattttt cgatcttggc 3158761 agattttaat tttaattcaa gatatacgcg ggaatccttt gaatatttgt attttggatt 3158821 tgtcctgccg tactcctttg atgtataaga gacatcataa tgctgttcaa atgatctaat 3158881 gagctgttca atttcttctt gttttccagc tagccttacc tgtgccactt cgtatcctcc 3158941 gctttcataa aaaaacttac tccatgaaat actctaacac agtatatcat ttttttaaca 3159001 ggaaaagata acctctacta aggttttgga taagaggtga cctcattgga acaaacagag 3159061 tttaaggaat atatacacga taatttagca ttggtgctgc caaaattaaa agaaaacgat 3159121 gatctggtga aaaacaaaaa aatgcttgcg aacggactgg ttttttacta tctctatttc 3159181 agtgaaatga ctgatgagaa taaggtgtca gaagccatta aaactttgat taaagatgag 3159241 gagaccttaa cgcttgacca ggtcaaaaaa cgccttgacc agcttgacgc aagacctgtt 3159301 gaaactgcaa aaaaaacgat tgaatcgatt ctcaacggca attgtgctgt gtttatcaac 3159361 ggattggata aagcctatat tctgaccaca ggaaagaaaa aaacaagaag cctgacagag 3159421 ccgacaactg aaaaagtggt tcgcggccca aaagtagcgt ttgtagagga tattgataca 3159481 aatctcgctc tgatcagaca aagaacctct catccgaaat tgatcaccaa aaaaatcatg 3159541 atcggcgaaa acaagctgaa gcctgcagcc attatgtaca ttgaaggcaa agcaaaaaag 3159601 tccgtcataa aagaagtgaa ggcgcggctt aaaaatatcc agctggaaga tatccaggac 3159661 agcggaacgc tcgaggagct cattgaagat aataaatatt caccatttcc gcagatacaa 3159721 aatacggaaa gacctgacaa agtatcttca gccctgttta acggccgtgt ggcaattttg 3159781 gtcgacagtt caccatttgt gctgctggtg ccggtttctc tcggcatcct gatgcaatcc 3159841 ccggatgact actatgaacg ctggatttca gcatctctta tccggtcgct gcgctttgct 3159901 tctatcttta tcaccttgtt tttgtcatcg atttatataa cacttgtttc cttccatcag 3159961 gggctgctgc cgaccgcact cgccgtcacg atttcggcga acagggaaaa cgtgccgttc 3160021 cctccgatat ttgaagccct gctgatggaa gtcaccatcg agctgctaag ggaagccgga 3160081 ctgcgactcc ccaatccgct cggacagacg atcggcctcg ttgggggcgt agtcatcgga 3160141 caggctgctg tagaagcgaa tctcgtcagt tcgattttgg tcattgtcgt cagtgtcatt 3160201 gccctggcat cctttaccgt tcctcaatac ggaatgggtc tgtctttccg ggtgctgcgt 3160261 tttatttcga tgttttccgc cgctatttta gggctatacg gcattatttt atttatgctt 3160321 gtcgtttata cgcacttaac gagacaaacg agctttgggt ctccgtattt ttcgccaaac 3160381 ggattcttta gcctgaaaaa tacggatgac tccattatcc gtctcccaat taaaaacaaa 3160441 ccaaaagagg tgaataatcc aaatgagcca aaaacagact ccactgaaac ttaatacctt 3160501 tcaaggtatt tctattgttg caaatacaat gcttggggcc ggacttttaa cattgccgcg 3160561 agcgctgacc actaaggcta atacgcctga cggctggatc acgctgatat tagaaggttt 3160621 catttttatt ttcttcattt atttaaacac gctcattcag aaaaaacatc aatacccttc 3160681 actctttgaa tatttgaagg aagggcttgg gaaatggatc ggcagcatca tcggcctttt 3160741 gatctgcggc tatttcctcg gcgtagccag cttcgagaca cgggcaatgg ctgaaatggt 3160801 gaagtttttc ctgctggaga gaaccccaat tcaagtcatt attttaacgt ttatttgctg 3160861 cggcatttat ttaatggttg ggggcttaag cgatgtgtcg cggctgtttc ccttttattt 3160921 aacggtaacc attattattt tgctgattgt gttcgggatc agttttaaaa tttttgatat 3160981 caataatttg cgtcctgttt taggcgaagg ccttggaccc attgcaaact cccttaccgt 3161041 cgtttccatc tcttttttag gaatggaagt gatgctgttt cttcctgaac atatgaagaa 3161101 aaagaaatac acgttcagat atgcgtctct aggatttctg attccgatta tcttatatat 3161161 ccttacgtat attatcgttg tcggagcttt gaccgctccc gaggtgaaaa cgctgatttg 3161221 gccgactatt tctctctttc agtcctttga gcttaaaggc atatttattg aacggtttga 3161281 atccttttta ctggtggtct ggattatcca gtttttcacc acatttgtca tttacggata 3161341 ctttgccgct aacgggctaa agaagacatt tggattatcg actaaaacaa gcatggtgat 3161401 tatcggcata acggtctttt atttttctct ctggccggat gacgccaatc aagtcatgat 3161461 gtatagcgat tatcttggct atatttttgt ctccctgttt ctgcttccgt tcattctctt 3161521 tttcattgta gctctcaaga ggaggattac aacaaaatga aaatccggat tttatgtatg 3161581 tttatatgca ccctattgct gtccggatgc tgggacagtg agaatatcga ggaattaagc 3161641 ttagtgatcg gaatagggct agacaagcct gacgatgaaa atttagagct gacacagcaa 3161701 attctcgtgc cgaaaataat cagcgccaag gagggctctt catctgatcc gacacagctt 3161761 tctatcacaa agggtaaaac tgtccatcaa atgatgagaa cctctgcatt aaagcataag 3161821 cctacgtttt cacagcattt gcgtctcatt ctgctttcca aaagcgtgat tgcggatcaa 3161881 attggaatgg acgccattat taaccagttt gtcagagaca acggaacaag gaggagttcc 3161941 tacgtcttta tcaccaacgg ccgaactaag gatatattta acatgaatga tgaaggcgaa 3162001 cccgcatcca acgtgatata tgatctgaca gagaataata aggtgacgat cagaacgatg 3162061 gagccagtta cattggggga gatctcagaa cacttaacct ctgacgattc attcctcatc 3162121 cctcatgtcg gtaaggaaaa cggcaagctc gcgataaacg gagcctctat cataaaaaat 3162181 aaattatggc accgggacct caccccgatt gaggttcaaa atatcagctt attttcaggc 3162241 actgtcgagg gaggcgtcat tgacttgaag cgcgatggcc atctcttttc ttatgaagta 3162301 tattcaagca atcggaagat caagacggca tacaaggacg gaaagttcaa attcaccgtt 3162361 acccgcaata ttgaaggtcg tctatctgag gactggaatc ccaatgaaga ctcgtttaag 3162421 gattcatata ttaaaagtat tgaaaagaca gtcgaaaaac gagtacacga aacagtaacg 3162481 tcatttatta cagagaagct gcagaaagag atcaaagcgg acgtaaccgg gctgggaaac 3162541 gaggtcagaa ttcattatcc tcaaaagtgg aaaaagattt caagaaaatg ggatgatgat 3162601 tatttcagca atgcggaaat agactaccgg gtcaatgtga ttgtcagaga cttcggaacg 3162661 aaaggcgcaa acaaatagca gccgcctaat tcacgagatg atttcggtgt gcgtacaccg 3162721 ccgcctgcgt ccggtcactg acatccagct ttgataaaat attcgtaata tgtgttttga 3162781 ctgttttaat cgtaataaac agttcctcgc ctatttcttt gtttgtcttt ccttctgcga 3162841 tcaggcagag tatttcgagc tcccgttttg taagcgattc atgcgggagc gcgttttcac 3162901 ctgagtggcg cagcctggat aatacttttc ccgccacttt tgactccagc ttcggctctc 3162961 ccttgcttgc ggcgcggatg gcatcggcga tttctgccgc ttttgaggtt ttcaacagat 3163021 agctgagcgc gccagcttca ataaccgggt acactttgtc atcatcaatg aagctagtga 3163081 gcacaataat tttcgggtcg gaaagctccc ggcaaatttg ctttgtagct tcaatgccat 3163141 ccatgccctc catgacaagg tccattaaaa tgacatcagg cgacagttcc acagcaagcc 3163201 gaacaccttc gctgccgtcc gatgcttcgc cgatgacttc aatatcgggc tgcgcctcca 3163261 aaaaagccgc gagccccatt ctgaccattt catgatcatc aatcaataat actcgaatca 3163321 cgttcgttct ctcctttttc ttccggaaaa atcgggacct tcacttcgat ttgagtgcct 3163381 tttccttcta ctgaaatcac ttcggcgaca ccgccgattt cacttgcacg ttctttcata 3163441 gaattcaagc cgtatgagga ggctttcacc tggtccattt taaagccttt tccattatca 3163501 atcaccttca gacggagctg gctgttcttt atgcccagaa tcacggttac ttttgacgct 3163561 tttgaatgtc taaatacgtt tgaaagggcc tcctgcacga ttctgaacaa gtggtcttca 3163621 acacccttgg atatcgctgt gtcctgtata tcccactcaa tatcaatcgg ctgctttttt 3163681 cggaactcgt ccaaaagctc cgtaaggccc tccttcagcc cttttccttc aagggtaaca 3163741 ggccgtaaat ggagcagcag cgccctcatc tcattttggg cttcgcctgc catatgctcg 3163801 accatcctga tccgcttgac tgttttgtca tcagcatcct tgacatgttc cagcacggct 3163861 gatgtcatca tcgatatggc aaagagctgc tggctgaccg catcatgaag atctctggcc 3163921 aatcgctggc gttcttctga gataaccgac ttcttcattt gagcctgcca ttccgcacgt 3163981 tcattggaaa gtttctggag ggatgcgact tgaagctcca cgcgcttcgc catttcgttc 3164041 agctgatcag cagccaggcc gatttcatca tcaccgagcg gcggtatccg ataagcgaaa 3164101 ttgccgtttt caaaggttaa aatggattca attaatgtat caatccttgt cttcaaccgg 3164161 ttgccgtaca tataccctga ggcgaaaccg acggtcacgc tgatcagaag caaaatcagg 3164221 ataaacggaa ttccgaacca gcttgatgac agcaaaacaa gcggatcgag ccgatagtaa 3164281 aacatcataa aggaaatcag gcaaacaaaa aggagcaggc tgattcccgt tgtcatgcgg 3164341 atggcgcgcc attggaggct ggcaagcatt ttttttctca tacgtacttc acatccacat 3164401 caccgataaa taaggaaacg gacactttta cccggcgctt tgactcgcta aaatcagttg 3164461 acgcggcata taccttcgtg cttaatccgc ttttcttcga gccgatcaga ttaatgtctc 3164521 ctataaaaac agccgagctg acagccactt caaggtccga tggtacataa atatcaacgt 3164581 taccaatgac tccgctaatg acgattgtac tttctccctc gggaatcatc gctttagata 3164641 aatcgatttt gatatcaccg ataaaaccag agacatttaa atcgttcagg tcaaacggct 3164701 gcttcatcat ttgcagctca ccgataaaaa agctgcgcat gtcgggatgt tttacatctt 3164761 ttggcggctc atgatgttct tttttattga gattgacctg tttctcattc ggttcaaata 3164821 tcggcttccc tttgataagc ctgtagccgg cgtaaatcag aaatgcggca aacgcatagc 3164881 cgaataaatt aaaggtgatg ctgaagaggt ttttcaaaaa tagaaacgcg gcaaagatat 3164941 acatgacgga gccaagccaa tcacgggaat attttttaag gaaatagccg gcaatcagaa 3165001 aaaagagcgg ccaaaacagc agatcgccta ttccgataat ttgcaaaaac atactgatgc 3165061 cgaataaagc aatgatcaat ccgagaagct gtttttttgt cattcctggt gtccgcctcc 3165121 tttcttctgc ctagtgctac cgtatcgcta gatccccgct gtccgttttg atgtcgattg 3165181 gatgccggcc gcttccttgc gtgcctgtga tgtgatgctg ttctttatgt cctttatcag 3165241 caaatgaata cggcgaactg acgtcaccgc ttgctgataa agcattgact gcaaagctgc 3165301 cattttgggg aaggcttaca ttagcatcac cgcttgtcag cgtgacagat acgggaccgg 3165361 ttaccttttt caatacagca ttaaaatctc ctgaagtcat tttcacatca agagagcctg 3165421 atacatgaac cagatttgcg tcccctgaag ctaaatcaat gccggctgtt ttggagacgg 3165481 tatttgaaat ggaaacatcc cccgatgatg ccttcacttt cagatcttga atgcggacgt 3165541 ccgtcacgct cgtatttccg ctcgcagata ctgcgttcag cccggaaagc gcaagatggt 3165601 cattcccggc cacagacacg tcaccgcttg aggttcgtac tgccagatca cctttataat 3165661 catacggaag cctgacgata agagttgaac ggttaaatcc attcaaaaat tgaaattctt 3165721 tttcctttac ggtcagctcc agttttcttt tgttttcagt aacaaataac tttcctgagt 3165781 ctcctgaaat gcctgccgat atgtcacttc gttcttccgc tataatccgg acatccttgc 3165841 tatccgactc aatgaccatg ctgtcaatgt cccgcggcga tgcgctggct gaatcagctt 3165901 ctgtgccatt tatgaaacct aggcctgcag caaacacatc ttttacgacg acggcgaaaa 3165961 aaaccagaat accggcagtg atcaacagtt tgccaagcat ttttttcatt cggtttcatc 3166021 cttctcattc attctattat aaaggaaaag cttgcgaatt gatacgtgcg gaagggaagg 3166081 acttgaccgc aaatccttcc ccgttccgct tattcatttg ccgcttttgt ctggtctgat 3166141 ttttgcagtg aaagtgtccg cattttttca atctccgctt ccacatcgtc tgcgaattct 3166201 ttacgtgtaa gttctgtgcc ggcttccgct gactttgaat aattcgcgcg gatttccatt 3166261 tcttcaatac gattttcaat acgtaaaaat tcacgatacg cgctttcact gtcaattttg 3166321 tcaaatgtcg tattcatatg ctctttagct ttcgccgcat ttgcccgcgc aatcagcgcc 3166381 tgttttttat cctttacgtc ctgaagcttt gtttcaagtg cagccagctg ctctttcaga 3166441 tcagccagct gactgtttgc ctgttcatag gaagctttat gctcagccgc cttcccttct 3166501 aaatacttca tttcagtcag cgcctttttc gccagttctt cttcacctgc gtcaaatgcg 3166561 agctgtgcct gatttttccg tttgccagcc acttcagcgg cttcttcata ttttttctta 3166621 aattgatagg caatcgtgtg ctgtttcaca attgtttgct ttgcttttgc gatgtcgctt 3166681 tccatatcgc gtacatattg attcagcatc acctttggat tctccatttt atcaagtcct 3166741 tcatgaactg acgcaacaaa catgtctctg attcttttta ataccatacc tgattcctcc 3166801 taatatattg atattatttt ttcttcaaaa attcttccca ttcgtcatca aagtgagatt 3166861 ggtaggcagc agaagccggt tcaggatcaa aagatgatac accgttatca gctgatccgt 3166921 ttttcatcag cttccagccg taatacacca tagcggccgc caatgcgatt ccgacgacaa 3166981 acggaagtga gcagatgagc ataatggctc cgataccgcc cacgatgatt cccgtgatgg 3167041 tttttcccgc ggcaaacctt ttgattcctg cgtatgtcat caagctcccg atggcgagcg 3167101 ggatgataaa gccgaagctt cctcctccaa aaaagacgga gatcccaaat acaattaata 3167161 agaatccgcc tattgttttc ttgtttattt tcatgcagat cctcctttcg ttttccttgt 3167221 cttcatctta tacaagttgg aagatatgca aaacgaatca gagattgatt tttatataag 3167281 accggagtcg tatctcgcac cggacccatt ggcacaaaaa aacgccatgc acgaggcatg 3167341 gcgttttaaa accctttaca gatgaacact tgcttccctt tctttaatta ggtcggacct 3167401 ttctgctttg gccaattttg taaacagcaa gattccgata cccgcaataa tttcgacaat 3167461 cccaccgaca gcgatcactt tacctgagcc gaaagcatta gcggcatacc cgcaaatgac 3167521 agctccggca gggatcgaaa tatttgagat catatgtata acggcgtaaa cctgcggctg 3167581 atcctcacta tccacagacg tctggataat cgtgtactca ggaacattaa cagcactgac 3167641 tgcggcacca aaggtaaaag cagcgaaaaa gacgagcggc aaaaaggtat tcatcccggt 3167701 aataaagaaa gcaaatcctt caataatgcc ggcagtgacg aataacaagc cgtacctgtt 3167761 taccttgact ttcgccagca caaaccctaa taaaaacgcg cccgcggcgg tggtggcctt 3167821 taaaagcgag tatacgatcg gctggccgtt taaatcttcc gcaacgtata cggcagagag 3167881 cgcttcccat ggggcagccg cgaaattcat aaagatacag taaatggcga gcggatataa 3167941 aatctggtgt tttctgacga gcctaaagcc gcgtttcagt cttccgatat atgtgcctct 3168001 ctgtgtaaca accgcagact ctgattgaga ttcaaccgca gtgtacttaa taaaaagaac 3168061 gagaaaacct gacaccaaat agagcacaag tgcgataagc atggtataag aaggactaat 3168121 aaatgtaaga aaagcgccgc ataatgtgac agccccaagc cggacaattt gagcggagga 3168181 ttgcagcaca gcgtttgctt tttgaatgcc ctgttcattg acgatttgag gaatcaaagc 3168241 gatagaggcg ggattgtagg cagctccagt agctgaatgc acaatcataa gcgtcatgac 3168301 aaaccacagc ggagagaagc ccgcaaaatg acatagaggg ataatcaaaa caatcgccgc 3168361 ccttgtcaga tctgaaaagt acatccaaaa tttcagcgtg gtctgtttca taaaaggccc 3168421 cgtcacaggc gccagaacgg cttccggcaa aaacgtgaca gcaatcaata aagcagtgcc 3168481 gatcgcacct ttgccgtcat aaattaaaaa ccataatatt gaattaaatg cgaacatatc 3168541 gccggatatc ttgactattc ttgagaaaaa cagataattg aaatttctct tccagatgct 3168601 atcactttca attaaattca ccatccatca gagccccccg ttgcctattt tttacatcta 3168661 tttattacaa tatctcattt ttccattttt cagtcaataa ttcataaggt tcattttttg 3168721 tcgtaaaatg ggaaattgac agagtgaaaa acaaaaaaag ccggcatgta tttgaacacg 3168781 ccggctttcc ttttcacttt ttatgattcg ctgctgtttc ggtcccgaaa cacaatggca 3168841 cttctttcat attctacatc gccaataccg cttcttgcat tcacaacccg ggcggcggca 3168901 aagaaataat cggacagacg attgagataa cgcagcactg tttcatgaat ctcctccgat 3168961 ttcatcagcg ccaccactct tcgttctgcc cgccttgtaa tggtgcgtgc gatatggaga 3169021 agcgaagcac actttgatcc gcctggaaga ataaatttct tcagttccgg cgcttctgct 3169081 gtataggcat caatgcgcgt ttctaaaaag gaaacagatt cttccgttag tttatagtct 3169141 tttctttctg tgacgattgc cagatcgcct ccgcagtcaa acagctcatg ctggatggtc 3169201 agcagctcgg ctgtcagatc ttcaaagccg ggctgcccgg aaagctctgc caaagcaagc 3169261 ccgataaagc tgttaagctc gtcaatcgtg ccgtagcttt cgacgcgtag gctgtccttg 3169321 tccgttctgc ccccgactaa gcccgtttgt cccttatcgc ctgtttttgt atatagtttc 3169381 ataccctgaa tctcctttac agacttattc aaacaactca gcagcctctt ttatacattc 3169441 agctgtccct ttctttatca attggttcag ccgctgttct atgttttctg attgctgagt 3169501 ttgagtcgcg gcgatgagaa tatcacctgt gcctcctccg tctcccagca ctttcgtccg 3169561 ttctgcttcg gcagccataa gagctttgat gaagaattga tctgccgcat agccgttaat 3169621 caaaatccaa atcgaaaagc cggtctgaac gcatatgaaa acggataact ctccgtcttc 3169681 atatgttcga tacacgaaac ggtcaagtct ttctgaagaa gccatcgcac acgtctcctg 3169741 cagttgaaaa ccgctttctg aaagacaggc cgtaagtcct tctatcggat ctggctgatc 3169801 tggcagccgt ttatggatca gcgtcctgct ccacgaaaac cctgcaccga taggcgtgga 3169861 ggacaatgtt cgaagcggga tttccgtttg cagaagaatg tcatcacgcc ccgcttggag 3169921 caatgcttca aatgggatag actgccgctt cacgctatct ttttcaggct gaatcacaat 3169981 catcggttta ggtgagcttt gatgaaccaa ggcggtgaca tctgtatcgt acaccgcctt 3170041 tatgctttgt tctgtaacag catattccgg tttttgctta ggcccggcgg taccgttttt 3170101 cataaacatg agcccatcac agtacaggct tgcggtgttc agatcatgaa aaacgctgac 3170161 agctgccaat ccgctttctc tcgtcaggcg tttgatcaga tcaagcaggt ctttttgata 3170221 agccagatcg agaaaattag tcggctcgtc caaaaataaa atacgcggct gctgcgccaa 3170281 agcttgtgcc aaatacaccc gctgctgttc ccctccgctt agttcgcgaa tcggcttttg 3170341 cgcaaaatcg gccactcctg tttgctccat tgcttcctgt acaatggctt cacccttttc 3170401 agtctgctgt ctgaacagcc ccgtttggaa tggatatctg ccaaaggcta cagtttcttc 3170461 gacagtaaag gtgaaggctt gatccatttt ttgcggcagg acagccatga tttgcgccag 3170521 ttccttcggt ttatagtccg ccagcagttt tccggccaga taaaccctgc ctttcttggc 3170581 cggcagcgta cctgtcagca agtgcaaaag cgtggttttt ccgcttccat tagggccgag 3170641 aattccaaga aattctccct tctccactgt taagctgaca ttgttgatta ggcggctgtc 3170701 gccgtatcct cccgacagcc cttctgcctt catcataagc ttctcccccc gcgatgctgc 3170761 cgaattaaaa taagagcgaa cacaggcgct cccgccaagg acgtaatgat cccgatcggc 3170821 agttcaatcg gctcaatgat ggttctggaa agcagatcgg ctaaaacaag aaaccctgcc 3170881 ccaagcaagg cggacaacgg cagtaaatgc cgatggtccg ttccccacaa aagccttgtg 3170941 atatgcggaa tcacaaggcc gacaaagcca atcgtacccg atactgccac agcgcttccc 3171001 gtcaaaagag atccggctat taaaatcatc atcttcctct gctgaacgct gactccaaga 3171061 agctttgctt tatcttctcc atatgtcatc acgttcagtt cccttccgtt tataatcaat 3171121 aaaatggttc ccaaaagaaa aaacgggaga aacaaaataa catagctcca gcccctcatt 3171181 gagacgctgc caagcagcca atgcacaatc ggaagcaggt tgtctcctgt caaggcgatg 3171241 ataagagaaa taaatgcgcc taaaaaagag ttggtgatga caccggtcaa aatgagggtg 3171301 gaaacagaca tcgaagcatg aacgaggcgg ctgaagaaaa ggaccgccgc catcgtggcc 3171361 agtgccgcgg ctacactcaa aaccgggagt gtaaaccctc cgatgacagg aaggtgcaaa 3171421 cctaagaaca gagtcacaac agctccgact gaagcaccgg atgacacacc tagcgtatag 3171481 ggatcagcaa gcggattttt caacaatcct tgaaaagcgg cccctgcaat agaaagagcc 3171541 gcccccacaa gggcggccag cacaactctc ggcagtctga tattcatcat aatattagtg 3171601 tacatcggat catcagaacc gatagagccg ccgaaacctt gatgccaaaa gacacgaaaa 3171661 acagcgggaa taggaatatg caggctgccg caagaaattc ctaagatgat gctcacggct 3171721 aaaaatgaga aaccaatgat atatgcggca taacgattat tccttaaacg tatccgggta 3171781 aatgctttcc gcaagttctt cgaccccttc gatcagacgg ggaccggaac gtgtcacaag 3171841 atcagggtcc acatcatata cacgatgatg tttcacagca ttgatttcgc tccagccatc 3171901 gcgtttttcc acagctttcg ctttcacacc gtccgttgta acaattgcat caggattgag 3171961 ttttacgatc gcctcgtctg tcatttgcac ccatcctgtc tgatccgcag ctgcgttttt 3172021 agcatggatg acatttagca tttcattcat aaacgtatct tttccggttg tataaatgtc 3172081 aggatcagga gaaacctcga taaatacgct tttctcctcg tcttttgaaa tggttttcgc 3172141 tttttcttga atatccttta gatctgattt catgcttttc acgagctgat cggctttttt 3172201 ctccgccccg ccagcttctc cgatcatttc gattgatttg tacacctcgg agaatgattg 3172261 tgcatcattg acagtcagca ctgtaatgcc cgcgtccttc agctgtttga tggcatccgc 3172321 tgatgctgac atggaagact catgggccag aacgagatct ggttttagag aaatgacttt 3172381 ttcaacgttt acattcatat ctccgacttt ctcaaccttt ttgacttcct ttggataggt 3172441 atcgtttgtg gtgacaccga ccactttgtc accaaggccg agtgcgtatg taatttctgt 3172501 gttgctcggc attaatgaaa caatcttttt tggctctttt ttgatggtta catcttggtt 3172561 tgacgcatca tcaatggtga cagggaacac ttctgttttt tgttttgcct ttgaatcctt 3172621 ctgatccgca ggattgccgc agcctgccag cataacagca gccaacagaa gcgcagccca 3172681 tatcccggct cgttttttca taatcttttc ctcctaaacg aactaaaaaa gcatctctac 3172741 gacggtaaag atgctgtaaa caacacaaaa aagcctattg tttacacatc atctgtcctc 3172801 gcagaattcg tgctgatcaa acaggcaggt atcctggctc ttggcgcttg gccaattaca 3172861 gtggcgggac cgcaccggct tttaccggtt tcccttttaa gccggctgtt gttcacggac 3172921 cggcacctat ttgacattcg tatccgtttt tcggagtaat tatactatat gactgacagg 3172981 cttgtatatg tgtcctgaat gacttttccc catattgtgt atggaagcaa aatcctcgta 3173041 aacactaaat ttgatcttgt atacttaata ccatcatcta tcaaaaggaa tgattcttat 3173101 ggatttacag ctaaaagaaa aactcgtctt aatcaccggc tcgacgtccg gtatcgggaa 3173161 agccgccgca aaaagctttc tgcaagaggg tgcggcagtc attgtcaacg gacgcaaaca 3173221 ggagactgtc gatcgcacca ttgaagagct ttctggctat ggaacagtgc acggtgctgc 3173281 tgccgatttg tcaaaaacag atgaagcagc ggcttttatc gaaaaagtaa atgaaatcgg 3173341 tgatatcgat atccttgtca acaaccttgg tttcttcgag gtaaaagact tcgccgatgt 3173401 gacagatgaa gagtggaatc aatatttcga agtgaacgtg atgagcgccg ttcggacaag 3173461 ccgtcacttc cttccaaaaa tgcttgccaa aaacagcggc cgcattttaa atattgcaag 3173521 tgaagcaggc gtcaaaccgc tgccaacgat gattccatac tcaatgacaa aaacggcact 3173581 gatcagcctt tcaagaggaa tggctgaaat gacaaaaggc acaaatgtga cggtcaactc 3173641 agtgctcccg ggacctactt ggacagaggg cgtggcctcc tatatggaag gcgccgcaca 3173701 agcagccgga caggatacag atacatttat caaagactat ttcaaggtca atgagccaac 3173761 ctcacttatt cagcgatacg cgacagcaga agaagtcgcc aacacaatcg tattcctcgc 3173821 gtctgacgcc gcatccgcca ttaacggcac ggcacagcgt gtggaaggcg gcattatccg 3173881 ttctctgtag tataaaaaaa cgcatccgtg tttcggatgc gtttttttta tacgtctcca 3173941 gcaaatggta ccggctgata tccgcctgtt tccagttgtg ctgaaaacaa ccctccagcg 3174001 tgaggctgct cgtatctctc tttttctgtc atttgttctg ttgccgttgt aatgtaaagg 3174061 gtttttaagt ctctgccgcc gaacgcgcag cacgtgacat atttagccgg cacgctgatt 3174121 gaattgattt cttttttctg aaacgggtca atgtgaacaa cgcggctgcc gccaaacagc 3174181 gccacccaca gcatgccatt ttggtcaatt gtcatgccgt ccggcaatcc gtctgactga 3174241 tcaaaacgat agacaggttc tggattcgaa acatctccgc tttgaggatc atagctgtaa 3174301 cgtacaatct cctgggtcgg cgtgtcgatg taatacatca aattccgctc gcggtcccaa 3174361 tccaaaccgt ttgaggtgga gacttgatcc ttgattttga caagactgcc gtctagattc 3174421 aaacggtaca gcgacgcctg tttttgctcg ccttccatgc tcgtcgtccc cgcccaaagc 3174481 cttccgtacg ggtcacattt agcatcatta aatctcaggc tctcatgcat gtccttcggc 3174541 tgtttaattt tttccaagct gtcatcccga agatgataca ggtaaaaccc gtccttcatc 3174601 gtcataatca gttcatcctt tgaatatttc gcaagcgccg tcacaaagga tttgaatttg 3174661 attgatcggt tgattttttc ttcagggtca aagatgtgga gctcgctccc caggatatca 3174721 acccaatata agcggccgtt ctcttcatcc cataacgggc cttcaccaat cactgcccga 3174781 gtgtctgctt ccaatactgc atccatgtgt tacacctctt tagcttcagt ctatatattg 3174841 ttattcccgg caaagaggtg tccaaaccac ttgatgttta ttgtttttta aaaaggatgg 3174901 taatgaccgt tccaatgttc gttctgctgt tcacatggat cgttccgtta tgcagatgga 3174961 caagctcctt ggcaatcgcg agcccgagac ccgttccggc agttgaatct tttgtgttcg 3175021 tccctctgta gtagcggtta aacaaatggg tgatcgtttc ttcatccatt cctttcccat 3175081 tgtccttcac ttttaaagaa atatgatttt ttgtttgctc cagaatgact tgaatctctg 3175141 ttcctttgcc gttgtgcttc acggcattcc caaggaggtt ttctaatatg cgcctgaacc 3175201 acgcttcatc aagggcaaat tcaatatgct cttctttgga tacaaacgag atatcatagc 3175261 cttcagaaaa cggatttttc ttaaaatcct caatgacatt tttaaaaaac gggataaggc 3175321 tagtgagctt tctctcaata ggaagagcat catttttcag gcgatacgtt aaatttaagt 3175381 cttcaatcag cttagacatg tattcagatt tttctctgac aacctgcccc atttctttca 3175441 cttcttccgg cgaccagtca tactgcttcg actcgagcat catgctgtag ccgtaaatgc 3175501 tgctgagcgg tgtttttaag tcatgtgaca aaccggcaat ccattcttcc cttgtcgcct 3175561 ggattttttc tctgtttctt ttatcccttc tcagcgtttc agtcagctga tccattgatt 3175621 caaatatctc accgaagaag cggtacggct gtttgatttt tcccttttta tttttgctga 3175681 caggacggcc ttcccggttt ctgggctcct caagcttccc ttttgacaga ttgaccagcc 3175741 atctaatcgt gtgaaaaatc ggcagcccga atcggaacat ataccaaacg gtcatccaaa 3175801 tgatatacat gaacaaaacg gccatcacga gaaacatcgc ttttaataca accttcagga 3175861 atgatttgtt aaactcctga tcggttacat agactgggtt cggcaccgta gcgaccatcc 3175921 atctgtcttt attgaggatc ttaacggaaa tttcccgctt atagttccaa ggcttagagc 3175981 tgtatttaag cagctccagc tggttcatcg tttttctctc gctttttgtg ctgttgatgc 3176041 tgtcgagaat ctttccattg ctgtctaaca ggtaaatggc gccttttttc cgtttaatat 3176101 agtcgatggt actagactta tagtgcgcta gtgagtctat cttttgttca cgcttttcaa 3176161 cggaagtcag gagctgttca ctttttgatt tccagccgga caatagaaga tacgacttat 3176221 cttcaatatt gatggcccaa taattcagtt tatagttatg aagctttttg gttttataaa 3176281 tagacaaaag ctctttcttg gtataggtgc ccggcacgtc ttttggcacg ccgtaggaat 3176341 aatcagtgtt tccttccgaa tcaatgattt gcatccagcc gtgctgttta tcaacagatt 3176401 tcttcaggaa attatccact tcccatgtcc cgtcttcgtt tacatcgaga tatgcctcaa 3176461 gtgtgtcggt cgttgctttc gtcagccctg aattggattc cgcatcgcta aaacgggcgt 3176521 ctaaatagaa aaacgatgca acaagcataa ccgtaagcag caggatcaca atcagcatct 3176581 ggccgaaaaa gtgaaacaaa aacttccatc ttaacctcat gaccgcttgc cttcaggatt 3176641 tgggataaaa cgatagccga gacctcgaac ggttacaata tactccggat tgctcggatc 3176701 gcgctcaatc ttctccctaa gcttgcgaat atgaaccatg acggtgttgt tgtcaccgta 3176761 ggaaggatag ccccatactt tttcatatat ttgatctttg gaaagcacca cgttagggtg 3176821 ttcacaaaaa tactgcaaaa gctgcagaag ctgggctgaa caggcaacgg cttccccgcc 3176881 tacgatcaac tcggcatttt gcggagaaaa agtaaagtaa tcatatgtgt aggtttgatt 3176941 tgaactcgtt tctttcgatt gatatgtacg cttgagatgc gctctgatcc gcgccgctaa 3177001 ttccagcgga ttaaatggtt ttgtgatata gtcatcagct ccaaccgcaa agcccgataa 3177061 tttgtccgcg tcggatgatc ttgccgtcag gaaaaaaatc ggagcgtctg aatactctct 3177121 gatcaatgtg caggcttcaa aaccggacat tccgcccatc atgacatcca gcacaatcaa 3177181 gtcaacctta ttggccttca caacgggaat cgcttcttct gcgcttgccg catccagtat 3177241 atttcgataa ccttcttttt cgagaacgcg tttgatcatg tccacaatcg ctttctcatc 3177301 gtctacgatt aaaattgacg cattttccac ttttatgttc ctttctgtca ctgttttttt 3177361 catcttatca ttatatcgtt tatttatggt acatttttga atacattgga gccttggcaa 3177421 atcaaaacag caaaaaagga gcaaacaagc gctccctttt gatgtttttt catatgaaaa 3177481 tattatgagt tctcatctac catgtacaaa ataaactccc aaaaccccgg tacatcctga 3177541 cataaaagca tatcagcctt ttcaaacatt ttgatcttca gctcttgctc taaatcttct 3177601 ctttcttgat aggacgtatt gctgagtttt tttctgatca tcggtgaaaa gcatgcaatc 3177661 aggtgctcaa tgtcataagt ctcgtctttt tgtttctttt tttgttcaaa ctggccgtcc 3177721 acagcttact tttccccctt tttttgcgcc gctaactgct ttctgatatt ctccagcccc 3177781 tttttatgaa tgttggagat gttttgtcgg gactccccta atgaatctgc aatctcctgc 3177841 atcgtggcac cgtgaagata gactttcgtc agcacacttt tttgtttgtc agtcagcttc 3177901 tggatcgctt ggtagagctg gtaatcctgt acatgctggc tcaaatcatc ctgcctgtct 3177961 aaaaattctt caaatgcatc gctacctgtt tcggaagaaa gccgatctcc cgcctccgga 3178021 tgatcaaccg tcagtggata ccgtttttgg tttttgcgaa cccgcttatc aaaatcaata 3178081 gaaaagatgc gaatcattga attcatatac ttgacgatgc ggatttcttt ataaaattgc 3178141 ttaaatagct cgtccaatga tcttgcatct ttttcgttag ggctttccat tacgtttttg 3178201 aacaaacggt aatgctgagg attgctcaaa aaatgcttca cgatgggatg cttcattatc 3178261 tccttacatt ttgaccgtaa aagactttga tagtccatca aaccgcctcc ctactaaatt 3178321 aaatgaagga aagcaaaaaa aagtaaacta ctactttccg cctagtgtct tccaaaatac 3178381 tttgcagcag tttacgtttt atcggttttc ctcacttaca tacatgactg cagaaaaaga 3178441 agggaggtat tttcctatgg atcaggtttt tatagaggaa gtcgtaaaac agatcggcaa 3178501 tttggggttt cccgcgctga ttgcaatgta tctgctgacc cgattcgaaa agaagtttga 3178561 tcaactaata gaactaatga cagaactgaa agatcatgca aaaaaataat ttttcaatcg 3178621 aagttgactt ttcactggtt tttttcactt aacaaaacag aagggaaaac gaaaggcctt 3178681 tcaccttctc tttctgctat cacatttaaa tgtaaggagg aaacatttca tgaaaaaaca 3178741 aaatgacatt ccgcagccaa ttagaggaga caaaggagca acggtaaaaa tcccgcgcaa 3178801 tattgaaaga gaccggcaaa accctgatat gctcgttccg cctgaaaccg atcatggcac 3178861 cgtcagcaat atgaagtttt cattctctga tactcataac cgattagaaa aaggcggata 3178921 tgcccgggaa gtgacagtac gtgaattgcc gatttcagaa aaccttgcat ccgtaaatat 3178981 gcggctgaag ccaggcgcga ttcgcgagct tcactggcat aaagaagctg aatgggctta 3179041 tatgatttac ggaagtgcaa gagtcacaat tgtagatgaa aaagggcgca gctttattga 3179101 cgatgtaggt gaaggagacc tttggtactt cccgtcaggc ctgccgcact ccatccaagc 3179161 gctggaggag ggagctgagt tcctgctcgt gtttgacgat ggatcattct ctgaaaacag 3179221 cacgttccag ctgacagatt ggctggccca cactccaaaa gaagtcattg ctgcgaactt 3179281 cggcgtgaca aaagaagaga tttccaattt gcctggcaaa gaaaaatata tatttgaaaa 3179341 ccaacttcct ggcagtttaa aagatgatat tgtggaaggg ccgaatggcg aagtgcctta 3179401 tccatttact taccgccttc ttgaacaaga gccgatcgaa tctgagggag gaaaagtata 3179461 cattgcagat tcgacaaact tcaaagtgtc taaaaccatc gcatcagcgc tcgtaacagt 3179521 agaacccggc gccatgagag aactgcactg gcacccgaat acccacgaat ggcaatacta 3179581 catctccggt aaagctagaa tgaccgtttt tgcatctgac ggccatgcca gaacgtttaa 3179641 ttaccaagcc ggtgatgtcg gatatgtacc atttgcaatg ggtcattacg ttgaaaacat 3179701 cggggatgaa ccgcttgtct ttttagaaat cttcaaagac gaccattatg ctgatgtatc 3179761 tttaaaccaa tggcttgcca tgcttcctga aacatttgtt caagcgcacc ttgacttggg 3179821 caaagacttt actgatgtgc tttcaaaaga aaagcaccca gtagtgaaaa agaaatgcag 3179881 taaataaaag acttgcggct tgcagagagc actcgttctc tgcaagcctt cataaggagc 3179941 tgaaccagtg aaacatcaaa acccttcaaa acgcttattg cggctctcca taaagtactt 3180001 gctggccgca gcagcagtgg tgttgaccta ttttgctgtc atctatatat tgttttcttt 3180061 agcgggaacg agctaccgct cagcagctca tgtcctgctt tttgccgtgg tattccttgt 3180121 tctcggatta tgctttgaac catttgaacg gctgatgata catagcttta catttttcaa 3180181 gacaggaaaa cgtctattca ttctccttgc tggcatcgta cagctgctgt ttttgtggat 3180241 gactgctcat acaacagacc aattgatcag cgacatctgg ctgtccacca cagaagaaat 3180301 gattgtcgca gccgtttttt tgattttaga caaatgcaac tcggctcttc ccagctaaaa 3180361 aaagaacgca ttccaattgg atgcgttctt tttattcata gcgaagcgcg tctacaggct 3180421 gaagcttcga agccttgata gacggaagca agccgaagat aatgccgact gccattgaaa 3180481 agatgagtgc tccgacaaca gctggaatgg agacgataaa aggcatcgga aaaatgaccg 3180541 tcagcagctt ggcgatgccg aagcccgcca gcacaccgag tattccgcca atgcttgtca 3180601 gcacgacagc ctcggttaaa aattgaaata aaatcacacg ccgcttagca ccgagcgctt 3180661 tcttaattcc gatttccctc gtgcgctccg ttacggaaac gagcataatg ttcatgacgc 3180721 cgataccgcc caccaaaagt gaaatactgg cgataccgcc aagcagcaat gcaaatgact 3180781 gattaaagga ctccacttcc tgcgcgatct cctgaagatc cattacactg tactctgctt 3180841 tttccagctc agcttctgac agtccctgat ttaaaagatc tgcagccatt acacccgctt 3180901 cttggatatg ctcagaagaa tcagcctgca cggcaatctg cgttggcgcg tcaaatcctt 3180961 caataagcgg ccacactttt ttcggcacgt acaaaaccgg gttcgcatag tcgccttcaa 3181021 acatgctttc ctgttgattt ttttctttaa aaacacccac gaccttaaac ggcacaccat 3181081 tcatctcaat gcttttatgc agagcttctc cgtctggaaa cagttcatct ctgacagctt 3181141 cattgatcat cactacttgg tgtgtgctgt ttaaatcgtt ttccgtcagc tttctccctt 3181201 cggttattcg gattggaaac atgtcgaagt aatcatcgtc cactccatac acttggggat 3181261 acgaaacgtt agttaaatga aaaacgctcg cgccttctga caagtaatat aaggataatc 3181321 ctttgaccat cggatctgat ttgatcgcct ttactgtttc ttccgctaca ggcggcgcgg 3181381 acgcatacga cacctgaggg ccgccgctct cctcttctcc gccagacggc tggtagacaa 3181441 cattgatggc gttgtttccc atgccgatca tactttgctt taactgctca ctttggccct 3181501 tcagcattga aacaatcgcg atgattgccg ctatgccgat aatgacgcca agcattgtca 3181561 gaatcgatct taatttatga gagaaaatgg attgaaagga gattcgaata tgttcaagca 3181621 tggctgatat cccctctctc atctaatacc aactctccgt ctctgataaa aacggttctg 3181681 tcagcttttt tggcgacgtc cgggtcgtgg gttatcataa taatggtctt gccttcccga 3181741 tgcagttcag aaaacagtgc caaaatttgt tcacttgatt tggtatcaag cgccccggtc 3181801 ggttcatcag ctaaaataaa cctcggctga ttgacaaggg ccctcgctat cgccacccgc 3181861 tgcttttggc cgccggacag cttaggcggt ttgtaggaga ccctgtcttt taatccgact 3181921 ttttccagcg cttcatatgc ccgttgcctt ctctcttttt tcttcacttt attgtagatc 3181981 atcggcagct cgacattttg cagcgcggtg agacgcggca gcaaatgaaa agtttgaaac 3182041 acaaacccga ttgattcatt gcgaatttcg gctaaagccc cgtctttccc tttcaatata 3182101 tcgatctggt caagcgtata ggttcctgag gttggcctgt ccaaacagcc gataatattc 3182161 attaacgttg actttccaga accggaaggc cccataatag ctaaaaactc ccccgcctga 3182221 acggtcagat tgatatgttt caagattgga acttcttctt ttcccagctt gtacgacttc 3182281 gaaatattat tcagtgtcag cattgactgt aacctgcttt ccttccttga ccgcgggatc 3182341 aggatagatc acataatctt ccggcgtcag gccgctctta atttccacca tgtcattttc 3182401 atcagtctct ccgatttcaa caggctgctt aaccgctttg tgattctcat cagctttcca 3182461 tacgtacggt tcgccgtcat cctgaatgac catgtcggac ggcagcttga tcgtgtccgc 3182521 atcagcatta tcactcatca cttcgatgtt gacatgatag ccgacttcaa gacctttatg 3182581 gctgtctaat aaaatggtga aaggatagtt agaggactgg ggattcattt cttcatcagc 3182641 aaagctttct gattcttcac cctcgcctgc tcccgctgga agcttgccga tcgaggtgac 3182701 ctttcctttc cactcgccct caccgcctgt tttcagcgtg accctgactt tgctgccttt 3182761 tttgatcgtg tccattaaca gctcattgat ttggcttttg accagatatt tgcctgtcga 3182821 aacaatctgg atatacgggc ctgctgcctg gtcgcctgtt gcaccgtcag cgatatcctg 3182881 attgacgctt tgaacgattc cgtcatgctt gcttgtaatg acattggaac ctttgttttt 3182941 cgtcaggcca gccagttctt tttgatgctg cttcagttca agctggcttg ttttcaaatc 3183001 gaaattggtt tgatcaagtt catcttgaag ctggtttttc tcttcttttc ctgcaacttt 3183061 cagctttttt tccgtttccg ttattgattt ttgcaaacgg ttgatttgca gatttgtcat 3183121 ttcaatttgc aaattggctt gctccacttc atcagaatga tcctcgccct catactcaaa 3183181 aagcttatcg ccctttttaa cctgatcgcc ttctttgacg tatgtttttt taatgctgcc 3183241 tttttctgaa tctatgtata ctttctgctg tttctcaggt tcaacctttc cagaaaacgt 3183301 ttggcctgat tctgaatctc ctcccatgta taccgcgacc gattcagcat agggctccga 3183361 tgatacggca acttggttca tgtgagtaaa aaagtaaaaa ccgccagcgc cgatcccagc 3183421 caatacaagc acaccggcac atatcgcacc gccaataagc cattttttct tcttggacac 3183481 aacgatctcc tctttctgta aactatgtaa tattttcgaa acattctaac caatattatc 3183541 tattaattca aaaagacttg caatcctttt attgaaatga cggaatcaaa tagaaaaatt 3183601 gtattttcaa agccgaataa aaaaaatccc ggcttcaaac cgggattttt tcatacagta 3183661 actagctctt tttcattttt aatcaagtca tatgtcaagc atacaggttt atttgtacgg 3183721 ggatcagtca cgatttcggc atcaatctga aatacctgct tcaaaatgtc tggtgtcatg 3183781 acctccagag cagttccttc cttgatgacc gtgccttttt tgagcgcgat catataatga 3183841 gaaaaacgag ctgcatggtt aagatcatga atgaccatta aaatcgtccg cccttgctct 3183901 ttgttgagtc tgtcaagcag ctgcagaatt tcaagctgat gtgcaagatc aagatacgtt 3183961 gtaggttcat ccagcagaag cagttccgtc ccttgcgcaa gcgccatggc aatccacaca 3184021 cgttgacgct gtccgcctga caatgcctca atcggccgtt cagcatattc agccatgcct 3184081 gtttcttcaa gcgcccattt gataatccgg cggtcttcgt catttaatct gccgaatcct 3184141 gattgatgcg gaaacctgcc gtacgacacc aattcgtgca ctgttaggcc gctcggcgct 3184201 tcaggtgtct gtggaagaat cgccatatct tttgcaatgt cctttgtaga cattttatga 3184261 atcgctttgc cgtttaaata gacggcacct gcatgtgaac gcataattct ggacattgtt 3184321 tttaaaatcg ttgatttccc gcagccgttc gggccaatta aggtggtaat tttcccttta 3184381 ggaatcgata tatttaaatc ctctacaatc accctgtcgc cataaccgat tccaagctgt 3184441 tccgttgata atgaattcat attcggcccc ctcctctaat tcgctttcat caataaataa 3184501 ataaagtaag gcgcacctag cacggaaatg acaagtccga ccggaatttc tgatggtgcc 3184561 aatacatttc tcgccagcgt atcagcaagc aaaaacagga atgagccgat gaaggcggag 3184621 accggtatca gcgtctggtg acgtggaccg gtcagccttc tagccacatg cggcgcgatc 3184681 aatccgagaa acgcaatgcc ccccgcagct gccacgcatg aagcggcaag agtgaccgct 3184741 gccagaagaa gaatccgtct ttccttttca acagcggtgc ccagcccggt cgccaattgg 3184801 tctccgagct gcataatgtt caaatagcgt gccttatata aagtaaacag aagcaagatc 3184861 acaatccaag ggagaatcgc ccagatcata ttccagttcg ccccccatat tgagccggat 3184921 atccaaaccg cggcttgcat aaaatcatga gggtccatct tgagctgaaa aatcagcaac 3184981 agggcgttga atccggcatt cacccctatg ccgactaaaa tcagccgaat cggtgtcacg 3185041 ccttttttcc atgccagaat ataaatgaga aacgcagcga ggattgctcc tgccaaagca 3185101 ctgaacggca gcataaatgt tccgaaaaag ctaagatctg aagctgaccc ttgaaaaaag 3185161 tatataaaaa gcactacagc aagtgaaccg ccggcgttaa ttccgagaat accaggctcg 3185221 gcaagttcat tttgagacac gctttgcaaa atggctccag ctacggagat ccctgctcca 3185281 acaagcaaag aaaggatgat ccggggcagc ctgaactcaa ataagacaag ttcatcacgc 3185341 gccgttcctt ggccgaaaaa gacctgaagc gttttaagcg gtgcaatttt gataacgccc 3185401 aaattgagac tgataaaaaa gaccaccacg ataagcaaaa aggtcacagc cattacaatg 3185461 agcggtttgt ttgtttttgt tttcattaca gccctctcct ttcacgacgt gccaaataaa 3185521 agaaaaaggg aacgccgata agagaagtca gcgcgccgac aggcgtttca aagggcgcat 3185581 ttacgagtct ggccgctatg tcagcaaaaa caagcaaaac agcaccgagc accgccgagc 3185641 aaggaatgat ccaccgataa tccacaccga ccaaaaaacg ggtaatatgc ggaatgatca 3185701 gcccgataaa tgcaatggtg ccggcaatgg aaaccgcagc tccggtcaga attactacaa 3185761 taagcatgcc aaccagtttc accgctgatg tatattgtcc aagccctttt gccagatcgt 3185821 caccgagact taacactgta acagaccggg cgatgaaaaa cgcgagcgtt aaaccgacag 3185881 cccctgcaat aagcaaaagc tggacccccg accatttcac acccgctacc ccgcctgcgt 3185941 accaaaagct gatatcctga gcgacatcaa agcggattgc aatggcagtt gaaatgccgg 3186001 taaagaaata agtaactgcc gtacccgcca gagcaagctt tacaggcgta agtccgcccc 3186061 ttgaaaacat gcctatgccc attaccgtcg atgcccccag ccccgctccc gcaaaggacc 3186121 atagcacaag ccccattgca gaaagtccgg gaaaaaaggc aaacgcaatc gaaaccgcaa 3186181 acgcagagcc tgatgtcaca cccataatcg aaggctctgc caaagggttt ctcgtcatcc 3186241 cctgcatgat tgctcccgac actgccaaca atgcgcctac aagcgcggca gccgccgttc 3186301 tcggaagccg aagatcatgt ataatttggt gagatgtctt tgtcggctga taatgaaaaa 3186361 tggcctccca tacagtgcgc aaatgaatat ccgctgcacc tagggatatg gataaaaatg 3186421 cgccaaggca aagcaggcat agacctgcga taaggacgat gaccgcgcca tatgtccttg 3186481 acgtccattg gatttcttct gatgcagtcc gtatattttt atgttgactc aactgccgta 3186541 cttcctttct gttactgata atgattatca attgctgttt cagtatatca cttttttcag 3186601 ctgatttaat agagtgtttt gaacaaaaat gaaaatgcat ttgcaaaaat atcgtgtcaa 3186661 ccggcacttg cagtggtata atcacagatg ataatgattc tctttttcat ctatctttta 3186721 gaaagaaggt atgagatatg acccatatat acaagaaact cggagccgcg ttttttgccc 3186781 tgttattgat tgcagcgctg gcagcctgcg ggaataactc agaaagcaaa ggttctgcct 3186841 ctgattcaaa aggcgcagaa acctttacat acaaggctga aaacggaaat gtaaaaatcc 3186901 cgaagcatcc taaacgggtg gttgtcatgg cagacggcta ttacggctac ttcaaaacac 3186961 tcggcatcaa cgttgtaggt gcgcctgaga atgtatttaa aaacccttac tacaaaggaa 3187021 aaaccaacgg cgtcgaaaac atcggagacg gcacttcggt tgaaaaggtc attgatttga 3187081 accctgacct gattatcgtc tggacaacac agggcgctga tattaaaaag cttgaaaaaa 3187141 ttgcgccgac tgtcgcagta aaatacgata agctcgacaa catcgaacag ctgaaagaat 3187201 ttgcaaaaat gacgggaact gaagataaag ctgaaaaatg gctggccaag tgggataaaa 3187261 aagttgcggc cgctaaaaca aaaatcaaaa aagcggtcgg tgacaaaacc atttccatta 3187321 tgcaaacgaa cggaaaagac atttacgtat ttggtaaaga ctttggaaga ggcggaagca 3187381 tcatttacaa agacctcggc ctgcaggcta caaagctgac aaaagaaaaa gccattgacc 3187441 aggggccagg ttatacaagt atttcattag agaagctccc tgacttcgcc ggagattaca 3187501 ttttcgcggg cccatggcaa tcaggcggtg atgatggcgg cgtttttgaa agctccattt 3187561 ggaagaacct gaatgccgtt aaaaatggcc atgtatacaa gatggatccg atcggattct 3187621 atttcacaga cccgatttca ttagaaggac aactggagtt tattacggaa agcttgacta 3187681 aataaacaaa agagccgcct gcccgcggct cttttgctta tttataagga acggctcaat 3187741 ttgaatcata tcggatattt tctttgagcc attcatatta agctgcatcc tcatcacgat 3187801 cagttttttt atgctggaga gactgaaaaa cgttttttgc atatttaacg aacggattcc 3187861 taacaggaga aattgtgatt ttataaaaaa gacacctgag caaatcaggt gtcttttcat 3187921 tatgcttgtt tttctttctg gaacttgtta ctcacaaatg gataaacgat taagccgaca 3187981 aagaataaac cgatgccgag tataaatgtc gttaaatctg ctgtgcctgt tacgataaca 3188041 aacacggagt atgcacacgc cagtatcgcg atcaatccgt ctcttacacg ggagcctttc 3188101 agctggtcat acgtttcacc tttgatgact accttcaagc tgtagattgc agataccaga 3188161 tacggaatta aatatgcgag tgtagccgct gtcgttaaaa atgtaaatgc gtcacttatt 3188221 gtccgggaaa taaccgagaa aatgaagacc tgtgacatga cgtttgtaat aatgagtgca 3188281 atgaccggac ttcccttttt attcgttttt gcaaaaaatg ccgggaaatc tcctgcttta 3188341 gcggcttggt atggcacctc agagccaagc aaaatccagc cgagcatcgt tccgaataaa 3188401 caaaggatag ccaaaagcgc cataatcacg cttcccgcgt ttccaacaat cgcatagagt 3188461 acatcaacaa atggtttttc agagccgaca agcttatcat gcggcagaac acccatcgta 3188521 attaaagtca caataatata tatgctcaag gcaatcagca agccggtaat tgtcgcacgt 3188581 ttcacatcac gctgagagcg cgcacggccg gacaggatca ccgcggattc aattccgaca 3188641 aacgcccaca gtgtagaaat cgcagcgtta tgaacctggc caccaattcc aatgcttgtg 3188701 ccgttttctc cttgaaccgg gaaataaaaa tgaccgaata atgacgtttg aaacacaaac 3188761 aaaccggcaa cgataaagaa gacaaaacct aatactttag aaagcgttgt gacaaagttt 3188821 aatttacttg cgccgttaat gctggcaaca agaatcgcgt gcgttcccca taacaagatc 3188881 gtacatacgg caaacgtcag taattggccg agtgtcacct cttgcccgcc gatcgaaaac 3188941 atctcacgtt tatcaaccaa gatcgggaag aacgaagtca agtaaccggc gagacttgtg 3189001 atgatcgcca cgttactgat ccagctcgcc acccagtagc cccacaccat tgtgaaaccg 3189061 gcagcgttgc cttttttcgg gtcagaaaac agcgctcttg cataactttg cggtcccgct 3189121 gtcagttcag gcttgcgaat ggacaagtgt ccgaacacaa gtgcaatcat cagcacgccg 3189181 gcacctgtca aaagccaggc ggacgtagct ccaaacggac tcgcaattga agcaagcgag 3189241 ctcggcaagg agaaaattcc tgatccaacc atatttccaa cgacaaacgc cgttaataac 3189301 caaaaacccc atttttttgt ctgttccatt ccagtacctc catgattctt tgtacggacc 3189361 agaccccgag atcatataaa cgcaaaaaaa gcctgaacaa aagtccatgc ttaaagaaac 3189421 acacaccctt gatctccgga tagccctccg cgaaaaagca cgcggcagtc ctgcacttat 3189481 tcagatacag tcccagcata gagaaggatc ggctttctcc acacttcggc gctgatgcct 3189541 tttacacatg tttaacagcc cctgtcagcc tagcatgtgt gactcatcat ccgcgcaacc 3189601 tctacctcac tgagaaagag tgaggattta attattcagt tactcccaga aggttatcaa 3189661 agaaaggatg atctgtcaaa gggaacagat ggaaaatacg gatagagcca agccctatcc 3189721 gcatgtggtt atcgattatt tttctttttt tgcacagctt cttgaagcgg atcatctttt 3189781 agagctgaac cagcatcttc aagagctcct tggattacgt ttttttcttt ttcggaacgt 3189841 tttcctttat ctttattaaa gaaacccatt cgtatcacct cttttaaaaa ataggtacat 3189901 gtttaagatg cctttttcct gaaaaattat gcgggatatt ttttatcgtc caaagtcctg 3189961 ttgatcaaac atacattctc ttgatatatt tgtaattcag agattttttg caaaagataa 3190021 aaggagaagc ggcaaatgac aggaaaaaca cacatcatgg gaggcatcgc ttcttgtacg 3190081 gcagcggctt attattatgg atttgatcca gtgcttatgg ctgcgtcagg cgcggttgga 3190141 gcattaatac ccgatatctg ccacacacaa agcaaaatcg ggagaaaatt tcctatttta 3190201 tcgaaagtgg tcagctccgt ttttggccat cgcaccttta cacacagcct gctgtttatg 3190261 ctcatcatgt tttttatcac ttctacatac attccagata aaaacatatc agccggcctg 3190321 atgatcggaa tggcgagcca cttgattctt gacgcttgga cggtgaacgg aatcaaatta 3190381 ttattccctt ccacgatccg cgttcggctt ccattatata tgaagacagg cagtttttct 3190441 gagcagctcg tgctagccgg cctgaccctt gcttcatgtt actactttta tatgctgttt 3190501 catggccgca tgttttaaac atgagtgctg agacttgtct gaaccggctg tttttagtag 3190561 gttttactta agaagcattt catgcagatg atcaagaaaa cgtgaggagt catattgatg 3190621 aaaggaacct tttttcacaa tcagcggttt ttatgttttt cgatcttatt tatgtggatc 3190681 aaaacgtatg tgatatataa actcggcttt gatttgcaaa tcgatactct gttggaggag 3190741 ctaatgctgc tggtcaaccc gctcagcttt attcttcctt tattcgggat cggcctgttt 3190801 ctaaaagaaa acaagcagcg ggcctttttg ctgattgcca atttggttct gactgttatc 3190861 ttgatctcta atacgatttt ttacggcttt tatatcgatt ttattaccat cccggtttta 3190921 tttcaggcca gcaacatgag cgatatgggc agcagtgtaa aagaactgtt ccatcctctg 3190981 tttatcgccc tgtttgtgga tttggttttt ctgctgttgt tcgccagaaa aaccaaacac 3191041 ccacagacaa aagccgctcc ccacacgatc aaacggtact atgcagcttc ctgcggaatg 3191101 cttttatgca cactggcact tgcagaagta cagcagccga agcttttggc acattctttt 3191161 gaccgggaaa tgctagtcaa aagcatcggc ctgtttcagt tccatattta cgatacaatt 3191221 tctcagactg ttaatatcag cgcgaaagct tttgccgatg aagacagtat aactgccatt 3191281 aaaaactaca cagaggctga ttacagcaag cctgatcaaa gcaaattcgg tcttgcaaag 3191341 gggcgcaatg tcatctttgt aacacttgag tcgacccaaa gctttgttct gaatgaaaaa 3191401 gtaaatggaa aagaaattac cccatttatg aatgatctca taaaaaaaag ctattccttt 3191461 gatcatttct atcagcaaac agaacaaggc aaaacatcag attcagaatt tatcgtcgct 3191521 aactcactgt atccctccct tagcggcgcc gtctttttca cgaaaagcga ccatcaattt 3191581 catacgatgt ataaatcgct gaagcagcac gattattatt cagccgtctt tcacgctaac 3191641 cataaaacat tttggaacag agatgtcatg tacgatacat ttggcattga ccgctttttt 3191701 gatgttgatg attttcatgt cactcccggg acatcgacaa gctggggctt aaaagacaaa 3191761 gaatttttag agcagtccgc caaaaagctg aaaagcctac cgcagccgtt ctacagcagt 3191821 tttatcacgt taacgaatca ttttccgttt gagattgatg aaaaggatca gctgatagat 3191881 gaattcgatt caagcagtga tctgttaaac cgctatgtga ccacggttcg ctatgaggat 3191941 gaagcattga agcattttat caaaaaactg aaggacgaag gcttatacga aaattcgatg 3192001 atcgtattta tgggagatca ttacggcatt tctgaagccc ataacgaggc aatggctgag 3192061 tttttaggga aagacgaaat cacaccgtat gacaacgttc agctccagcg ggtgccgttt 3192121 atcatacata tcccgggaat caccgatcaa cagccggaaa ccatccctga tgccggggga 3192181 caggtcgacg tcaggccgac gctgatgcat ttgctcggcg ttgagacaaa aggcgatatc 3192241 caattcggca atgatttgct gtcgggcgac cgcaccccat tcgccgttct gcgaaacggc 3192301 agctttatta cgaacgatta tgtatacaca aagaacacgt gctatagcca aaaaacaggt 3192361 gaagtgctgg aagatcagga tgcgtgcctc ccttacaagg agaaagcaaa cgaagaactg 3192421 tctctctctg ataaaatttt aaatggtgac ctgctcaggt tttccgaatg aaaaaatccc 3192481 tctatcaaga gggatttttt acgtttccaa tatcaccttg ccagtcagct tcgtttcata 3192541 gccgtttaaa tgagacagat tcgccttgta gtcctcagaa ttcaaaatct ccttcacggc 3192601 tttgagcaac tgctcatttt ttttcaaaac aacgatatca tattgttcgt cgatgagcgg 3192661 gataaaatca acactgccca tatgtgccgc gtgctgtgcc ccgattcccg cgtcagcctg 3192721 tccgcttgaa acttgtgaag cggcagcgta atgatcagtc acgatatcgc catatcccac 3192781 tacatcagcc ggattcacac caagcaagcc aagctgttca tcaaggagca cccttgcgcc 3192841 agaacccttt tccctgttga tgatccggat atcggctctt ttcaagtctt tccagccttg 3192901 aatgtttttc ggattccctt tttgcacata cagtcctgct ttgcggagaa cgacattgat 3192961 gagacaaaac ggttcacctg tcaaaatccg ttttacataa ggcgcgttat actggcccgt 3193021 ttctgcatcg tacaaatgga ggctgacaat gtcacacttg ccttgataca tatcaatcag 3193081 gctgtttaag cttcctttgt atttacggag cggcgtctcc tgaatggcat tctccaaatg 3193141 cttgctgagg atatccatcg aaatgtcctg tccgctgatc atgacatttg gtctgccgtc 3193201 cggctcagcc tcctgcacct gtttcggcgc ttcttttgca gcgatgggct gagacattct 3193261 catattcgtt ttatattgct ttaaatcttc ttcatccaca cgcatctgcc ttccgacacg 3193321 gtaagcaggc agcacgcctt ttttaatcaa gtcataaacg gtcagctttg ataccttcag 3193381 cagacctgca acttcttcta tcgtatagga agaggtttca ttcatcatca tcactctcct 3193441 attttattat accttttcgc cgaatgtaaa aaaacccaca taaaccaaac ataatcagtt 3193501 ataattagtt atatctaatg ataaggggtg caatcatgtt taagaagtat tctattttca 3193561 tcgcagcctt aactgctttt ctgcttgtag caggctgttc ttcaaaccag tcttcaacgg 3193621 acagcgagaa aaaagtaacg ttaaccatct cagctgccgc cagcgcgcag gatgcacttg 3193681 aggaaatcca aaaaaattat gaaaaagatc atcaacatat aaccatccaa gataactatg 3193741 gctcatccgg cgccttgcaa aaacagattt ctcaaggagc aggagcagat ctgttcttct 3193801 cagctgctga ggataaattt aaaaagctgg tggatgatgg agatatcgca aaaaaagaca 3193861 gcactgaatt agtcggtaat gaaattgtgc tggtcgtacc gaaaaacgga gattcacctg 3193921 tgacaagctt cagcaatctg gctgaatcag aaaaaatcgc tcttggcact ccggaatccg 3193981 taccggcagg agcttatggg aaagaatcac tgacaaagct gtctttatgg gacaaagtga 3194041 aggataaaat tgtgtatgga aaagacgttc gccaagttct ttcttatgtt gaaaccggca 3194101 atgtagacgc aggtgttgtt tataaaacag atgccctagt ctcgaaaaag gtcaacattg 3194161 ttgacgaggc aaaagcagat acacacagcc caattgtcta tccgttagga atcgtaaaag 3194221 atacaaaaca ccgtaaggaa gcgaaggaat tttacgaata cctgcaatct gatgaagcaa 3194281 tgaaagtatt tgagaaatat ggctttactg ccgagtagca taagcgcttc agaatttttc 3194341 acacccgttg tgctttcctt tcaggtggcg gcagttgccg gaattgttgt cattattctc 3194401 ggaacacttg ctggagcatg gatgtcacgg gcatcatttt tcggaaaaac ggcactcgaa 3194461 acatgtttta tgcttccgct cgttcttccg cctactgttg tcggttttat tctgatcgtc 3194521 attttcggaa agcacagctt catcggacaa gccatcgagt ggattttcca gcagcctgtc 3194581 attttcacct ggtgggccgc tgtgatcgcc tcggctgttg tagcctttcc gcttatgtat 3194641 caatcagcca aaaccggatt tgctgacatt gatcccgata tacaaggtgc ggcaatggta 3194701 gacggcgcta gcagatggaa agtgtttatc catatctccg tcccgcttgc ctatccttcg 3194761 ttactgaccg gaagcatcct tagccttgcg cgggcgctcg gagaatttgg cgcaacactc 3194821 atgtttgcag gaaacatccc cggtgttacg caaacactgc cgacggcgat atatgtcgca 3194881 ttggattccg gcaacaatac ccttgcttgg gcgtgggtcg tctgtattgt tgtcatttcc 3194941 tttttgatgc tgtttttcat tcaacagaaa aaaacgcact aaaaaaactc cccataacgg 3195001 ggagtttttt gattaaaaca gaagctcatc aggatttgga ccgacacgct catctttatt 3195061 taatgcgtca attttgtcca tgtcttcttg agacaattcg aaatcaaaaa tatcagcgtt 3195121 ttcgatgata cggtgttctt taatggattt tggaatggtt acaactccat gctgcagatc 3195181 ccagcgcaaa atcacttgag ccacagattt attgtgtttt tcagcaatct gtgtcagtac 3195241 ttcgttatcc aaaagctgtc cctgcatgag cggagaccac gcttccagct gaatgccttg 3195301 ccctttgcag taatctctta attctttttg cgtcaagcga gggtgaaatt caacttggtt 3195361 caccatcggt ttgatttcag catctttcaa cagctcttct aaatgatgaa cttggaaatt 3195421 gctgacgccg atcgcgcgaa ttttgccgtc tttgtacagc ttttcaagcg cgcgccatgt 3195481 atctttatat ttatctttgc caggccaatg gatcaaatat aaatctaagt aatcaagctg 3195541 cagtctttct aggctttttt caaaggcagc aagcgttgtt tcatagcctt gatcttcatt 3195601 ccacactttt gatgtgatga agagctcttc tcttgccaca ccggattctt taatcccgat 3195661 gccaacgcct tcttcatttt tgtagatcgc tgctgtatca atactgcgat agccattttt 3195721 aattgccgct ttcactgatt cagtcgcttc attaccattt tctactttaa aaacgcccag 3195781 accgaaccaa ggcatttcaa ctccgttatg taactttaca gtatctttta aacttgttgg 3195841 cacttgaacc tccacccttt cactgaaatg taagcgtcta tattatctca cattcctctc 3195901 agccgatacc aataatacgc ttaagaccct ctttttgctt cttttttcac agcacaggca 3195961 aatccaaaca ctattttttt cctattttaa caatattgag attacaaata cattgagcag 3196021 ggtatgcgtg tagtgtaacc aaatgaaaac aaaggaggaa acaacttgaa acgtattcgt 3196081 atcccaatga cacttgctct tggtgccgct ttgacaattg cccctttgtc ctttgcttcc 3196141 gctgaagaaa atcctgctcc gaagatgtcg cagacaacta ctgctggaac aactgccgct 3196201 gatgtaggtt taaacgtcaa cctggatgta cttggaattg ccaaccagat cgctgatgcc 3196261 atcaaatccg cacagaatag ggatggcttt gtgaaaaacc tcatggagtc ttccttctac 3196321 gcgtccggcc aaaaatataa cgtcatggtc tttaatttaa gccaggaata tgaagatcat 3196381 ttgaacggtg tgcaatttta cggctcagcc gtttacgacg gcattacgta tggcatttgg 3196441 gtatttgaag atggaacctt tacaaacaaa ggcgatggcg gctggatcaa ctgggccttc 3196501 agaggctggt tcgaccggga tggcagcact gtcgcatttc atcgccctta atataaaaaa 3196561 agctggcgct ctaacgccag ctttttttct gcatttattc gccgccttca agcatggcgg 3196621 cttcgacatc attaatgtat tggcgaagct catgggagat gtcccgggaa atttccctct 3196681 cttcgaagag cgtttgaatt tcatttctga tcgcctgcac agccttcagc ttcacttcca 3196741 gcttctgatt ttcaaaatgg gcacttgatt ttaactcatg atggctgtgc tccagcctga 3196801 aaattaactg cttatagaat gtaatgacag ataaaaacac ttctttatgc tcatccgtct 3196861 tatgtttttc cagatattct atcgctgctt ttgccgtttt cactcttgtt gcccgtatca 3196921 atcccgcttc atttaaaatc gacatctccg gctttttatg ttcaccgaag aaaatccaat 3196981 acatcagcct cttgagcctt gtttttgata acccgacttt aaacgggttg gcatacaaaa 3197041 tttccaactc gttaaatcgt tcttgcagca catttgctgt ttcttccggg atgtctcccc 3197101 gctccagcat tttcatcagc gcctcttgct cagccttaac cccctgcgca cggacttttc 3197161 gctcgtgctt cttaatgcga ttagatgatg tatactgctg aaaacgaaga tttttcattt 3197221 tctcattgta ttcagctatc accgcaagag aggccgtttt gtttgtctca ttcatgtcct 3197281 ctttaatcgt ttgaagggct gttttgatca acttgcgtct cgccgtcagc agcttcttat 3197341 ttcgttcctc gtcctcttct tctttttcag tcagaattgg cagcacaacg gtggcaatga 3197401 caagcgtgca taaaatgacg ccggctgcta aaaagagaat cagatttctt tccggaaacg 3197461 gcgtaccgtc ctccaggaaa tacggaatgg aaaaagaacc tgcaagcgtt actgctccac 3197521 gcacaccgga aatcgaaatt aacagcgtcg aacgaagacc cggtttatag atgttctgat 3197581 ctttattaaa gaaccatttg ccgttccaga agaacagcac ccacaggaat ctaaggagca 3197641 ttaatgtaaa tgtgatgact aggatatagc cgatcacctt catgttgctg atggcagtgt 3197701 cgttaaagat aacagaaata acatcaggga tttgcgtgcc gagaataacg aagaccaggc 3197761 cgttcaaaat aaataaaata atgttccacg tacttgagga gacgatttgc agcttgatca 3197821 tcgttgattc cagacgatcc tgttcaaccg catgggtaat accgccagct acaacagcta 3197881 aaatgcccga aacgccgatt tcttcagctg ccaaataaat cacaaacggc gtcagaattt 3197941 gaatcagcat atgcatcgtg acatcctgca tgccaaggcg gcgcagaaat aggcgaaaac 3198001 gaataatcaa aaatgaaatg acaaccccgc acagcaagcc tccgagagaa ataaagacaa 3198061 agctgacagc cgcttgtgct aatgaaaatg caccagtcac tgccgctgca atcgcaaact 3198121 taaaggccac cagacctgat gcatcattca tcagcccctc accttccagc aggcgaagaa 3198181 tcccttttgg cattttcact cttcctgata atgcgctgac agcgacgaca tcagtcggtg 3198241 aaagaatggc cgcaagtcca aaggccgctg ccagcggaat agcaggaatc atccagtgaa 3198301 tcgtgtagcc gcctacaatc acagtcgcaa atacaaggcc gagtgcaagc aataaaatcg 3198361 gagcccttaa attccaaagc tctgcccgcg gtgtcctctt tccatcatta aatagcagag 3198421 gcgcgataaa aagaacaaaa aacaattcgg tgtttaattc aaaatgaagt ccctgtggaa 3198481 atgaggcggc aagaatccca agagccactt gaatcagcgg caccggaata aacggaataa 3198541 accggttcac gatattagaa atcgcaataa tcgttaataa tacgagcaca actaaaaata 3198601 tgtccaaatg catgacctcc ttcgtctgtt gtgtgtcggc atgatgagcc aaaaaatctg 3198661 tttgtctaaa agcccttgag ctagggtggc cttgcatccg ctatgtggtt tcgcaggagt 3198721 tctctccaca cttgtcttct tttatagtac cctttttagg gtattttttc tcatgatatg 3198781 ctcacagtga acttttttgc agaagagcaa attatagaaa aaagagacag gaagctactc 3198841 cctgtctctc gtctttcttt ctcaatcatg aaaattcgta ccgtcagttg ttgctttaat 3198901 aatgcccgcg cgaatgacaa agtcaccgaa atgctcgcct tcctcgcgtt ctttcgcata 3198961 gcgggaaaga aggatgcgca gctcgcttaa aatgtctgct tcaccgatgt tttcacggta 3199021 cattttgctt aaacggcttc cgtcaaacgc agcgccaaga tacatattat atttgcccgg 3199081 cgcctttccg ataaatccga tctcaccgag tgcatgacgt gcacagccgt tcgggcatcc 3199141 tgtcatgcga atggtgattt cctgatcacg aaggccgttt tcgtcaataa tctcttcaat 3199201 cttatctaac agggtcggca aataacgttc tgcttcagcc attgccaatc cgcaggtcgg 3199261 aagagcgacg cacgccatcg agctgcggcg aagcgctgaa tagtgcttgc cgtcagttag 3199321 tccgtactgt tcaattaaag cactgatttc ttctttttta tcgcttgaaa cgttcgcaat 3199381 cattaagttc tgattggctg tcagccggaa ctcacctgta tgaactttgg cgatttcccg 3199441 caagccagtc atcagcttat aatcatcgta atccgttata cggccgcctt cgacaaacag 3199501 cgtgaaatgc catttatcct cgatgccttc cacccagcca tagcggtcgc cgttatgatc 3199561 gaaatgatac ggcttcgctt cttccaggct ccagccgaga cggttttcca attcttcttt 3199621 tacgttttct aaaccgaggc ggtcaactgt gtatttgaac cgcgcatttt tacggacaga 3199681 acggttgccg taatcacgct gaatcgtaat cgttttttca gcaacgtcat acatttgctc 3199741 aggccggcag aaaccgatca ccttggctaa ttgcggatat gtcgcagtat cgccatgcgt 3199801 cattcccata ccgccgccga ttgccacgtt aaaaccgatc agcttgccat cctcgacaat 3199861 cgcaatgaat ccgagatctt gtgaaaagac gtcaatatca ttagacggcg gaacggcaat 3199921 accgatttta aacttccgcg gcagatagag cggtccgtac attggctcga cttcttcctc 3199981 cggcgtgccg gcaactcttt cctcatcaag ccaaatttca tgatatgctc tcgtccgcgg 3200041 cagcagatca tcacttaatt ttttagacca ctcgtatacc tctgagtgga tttcagattg 3200101 ataagggttt gatgcacaca tgacgttacg gtttacgtct ccgcaggctg cgatcgtatc 3200161 caaaagtgct gagtggatcg tctgaatggt tttcttcatg ttccatttca gaattccgtg 3200221 catttggaat gtttcacgtg tcgtcaattt taatgtgccg ttcccgtatt tctgggacag 3200281 gtcatccatg acaagccatt gttcaggcgt cgagacgccc cctggcatac gcacgcgcag 3200341 catgaactga tatgcgggct caagcttctg cttttggcgt tcatttcgga ggtcgcggtc 3200401 atcctgcaaa taactgccgt ggtgtttcat caggcggtta tcatcatccg gaattcccgc 3200461 actgattcga tcgagcatca cttctttcag cgtgccgcgc aaataatcac tttctttttt 3200521 aatgcgttca acatcacttg gagagccgtc cggtgctttt agaattttgg tcaccatgtt 3200581 gaaaaactcc tttcaagtca aatcaatata catcacgctg atagcgtttt tgctgctgca 3200641 tatcggcaag ataagcctcc gcctcttcgc ggctcatatt gccttctttt tcgataattt 3200701 caagcaatgt gttatggacg tcatgcgcca tgtgcttttc atctccgcaa atgtaaacag 3200761 ccgctccttc ttgaagccat tcaaacaatt ctgcgctatg ttcaagcatg cggtgctgca 3200821 catatacttt ttcttccgta tcacgtgaga acgccacatc catttttgtc agcacaccgt 3200881 ctttgagcca attctgccac tctgtctggt aaaggaaatc cgtgacaaag tgctgatcgc 3200941 caaagaacat ccatgccttt ccttccgctc ccgtctcctc acgctcctgc ataaacgaac 3201001 ggaaaggtgc gacgcctgtc ccagggccca ccatgataat cggtgtttca gggtctttcg 3201061 gaagcttaaa gttttgattg tgctgtacat aaaccggcag tgtgtctccc ggctgcagtc 3201121 gttccgcgca caaaatcgag cagacgcctt ttcgttcacg gccgtgcgca tcgtagcgga 3201181 ctgcgccgat tgttaagtgc acttcatccg gatttgcgga taaactgctt gcaatcgaat 3201241 aaaggcgggc aggcattttt cgcaaaatcg agacaaactc ctgcgcagat acactaaatg 3201301 ggccatagtc acggacgaga tcaagcaaat cgcgcccttc aatataggct tttacattct 3201361 cctcatttcc cggggctaaa agctctctaa gctcatcgtt ccctgtcagc tgggctgcct 3201421 gttcaagaag cggttttgtg agaacggtaa tctcatagtg agaaatcagc gcttctttca 3201481 gcggtcggac atcaccttgc ttattaagcg tcacaatttc ttccgggtcc caattcattt 3201541 ccttaaggag cagctcgaca agttccggat cgttttccgg atagacgccg aggctgtcac 3201601 caggctcgta agtcaggcca gatccttcaa gagacagctc cacatggcgt gtttctttat 3201661 ttgatcctct gccgtttaaa tttaaatttt ctaacacttc agcccgaaac gggtttgttc 3201721 tggaatacga agactcaccg gtttgtgacg cagccgccgg cgcaggcgcg gcgcttccgc 3201781 ccccagcttc atttaatcct ttcaatacac cctcaagcca ttcggctgcc ggttcatcat 3201841 agtcaagatc gcaatcaacg cgcggagaaa tccgttttcc gccgagttct tctaagcgtt 3201901 gatcaaattc tttccctgtc tggcagaaaa attcgtacga actgtcacca agcgccaaaa 3201961 cggaaaagcg caggtcttca agcttaggcg cccgtcttcc gtgcagaaat tcatgaaacg 3202021 acagcgcgtt atcaggcggc tcgccttctc catgcgtact gacgacgatt aaaagattgg 3202081 ttaccttctt cagctgattc ggcttaaaat cgctcatgga tgagacggtc acttgaaaac 3202141 cgctctgttc aagctgcttg ccggcatttt ctgcaagccc ctgtgcgttt cccgtctgtg 3202201 aaccataaag aacggtcact tcttttgaaa cggccggtgc cggtgcttcc gctgacacag 3202261 ctgccgccgg cgtacccgca gcttcttggg cggaaacaga ttgagcggat aaatatccgc 3202321 tcagccagat tttctgggat tcggtcaagg tcggcagaag gcggttaagg agctctgcct 3202381 gctcctgatt aaacggactg ttcattacct gaagttgcaa cgtatccacc tcacaaagtt 3202441 ataaactgat cgaaaattgc atctaattga actttaccgg aatactaggc ttaagtaaaa 3202501 tatatttaca tgatgataac tattaagaat cctaatgata aaacggctat gcttcatgta 3202561 aatagaaaaa agagaaggac tcccttctct tcattcagca atctgatata agtgaggcgg 3202621 cacagcggtt acaaacggac tggcttcacc tgtataaaat accgccagca tgtgcatcgc 3202681 acgggtgcac gcagtatata aaagcctgcg gtcgtgctct gtatgatagt gttcttcaga 3202741 tgcatcatag acaagcactg cgtcaaattc aattcccttc gctaaataca ccggaatcac 3202801 gcaaacaccc ttttgaaatg gttgattttc tttatgaatc aggcgaacat ctgtatattc 3202861 actcatgtgg gcgtgcgcct gtatgcattg atgcgcagtc ttgcagatga cggctattgt 3202921 ttcgtgccct tttttcttga gccggccaat ttcttgcgcg agcttttggc aaaggctctc 3202981 atgtccttca gttttgacaa cgagcggcat ttccccgctt ctattaaacg gctcaatatc 3203041 cgctccatct tgaagcatcg ctttggtaaa ctcgacaatc tgccttgttg atctgtatgt 3203101 tctctttaaa cgaacatact cagcaggctc atcctcaaag cacgcatcca tacgctgatc 3203161 cccgtttatg gtatgcgcgt agatggactg attgatatca ccgagcactg tcatgctggc 3203221 agccggaaaa atgcttctca tgtaagccat ctgaaacggt gaatagtcct gggcttcgtc 3203281 aataaataga tgtttgattt tcgtattttt ctttctgccc tcaatcagat cctgcatata 3203341 aagaaacggt gccgcgtcct catagagcaa tttattatcc gtaaatgccg aacgggtcag 3203401 ctcacctatc gcatccatct tctcatgttg aaattttcct ccccagccag aaaacaattg 3203461 caaataaagt tgtgtaacat caagaaatgc aaggagcctg actgcctgtt tgagcggttt 3203521 gaaagctttt ttcacaatga tggcggcaag cagctgctgc tctctttgat aatcgttaaa 3203581 cgtactctcg ctgaaccgtt tcctttcctg cagttttttg tacacgtcca agtagtcctc 3203641 tttgtcaagc agctcagctt catgaacaac ccaatccttt cgccgttcct ttttctcaag 3203701 cttgttaagc tcactcagca gccacttcgc ggtttgctcc atccgattcg gaatggagtg 3203761 attttgatcc aatgagtaaa aataggattg aatttgctcc tttgtgatca gcttttgtcc 3203821 gcggaatata atatttttaa aaatcatccc ttcagaggaa agccgtgtga cgtattcatt 3203881 aatgaattgc tgaaaggata aacccgcctt ccatgtgatt cctgcaagcc ttgttggaaa 3203941 atcgcctccc tttgtttcgg tcaggcaata ttcgagctga tcaaaggggc tttcacattt 3204001 gaacttgcgg ccaagacgat gctcgatata ttcctgaaac gtcgcctgct ccatattctc 3204061 ttctcctaac tccggcaaaa cagaggagac atagctgtta aataagaagt tgggtgaaaa 3204121 caaaacgatt tgtccggcat caatgacacc gcggtgcctg tataacaaat aagcgacacg 3204181 ctgaagcgca gccgatgttt tcccgctgcc agccgctccc tgcacgatca ggatcttgct 3204241 tttttcatta cggataatct gattttgttc tttctgaatc gtagacacga tgtttttcat 3204301 ttgggtatca gagtgatggc ttaatacctc ttgcagcatt tcatcgccaa tcgtcatatc 3204361 ggtattaaac atcgccttga gagtgccgtt tttgatcata aactggcgtt tcagcaccat 3204421 ttccccttct atcgtttcac cgggcacctc gtactccgct tttcctgggg aataattgta 3204481 gtacaaactt gatatcggcg ccctccagtc atagatcaga aagtgttcct ccttctcatc 3204541 caaacaggaa gctaaaccga tataaattcg ctctgcctgc tcctcgccgt tttcaataaa 3204601 atcaatccgg ccgaaataag gcgatttttt caattgatga attcgtttga gctgctgatc 3204661 catgcgccga tgattgtgtt cccgatcaga cagcagctct gcctgctgct taatgctagc 3204721 catcgtttca atcgcttcat gggcatcatc aaaattaacc ttaacatcct cccaaaagct 3204781 ttttcttaat ccgatgatat catgcttcaa cccgcccgca gacgtttcca gaaaccgctc 3204841 ttttttttcg agctccttca gcacctcatc tattctcgac tgctcttcct tccattcctt 3204901 atcctgctga ttcatgaacg gcacctccag aaaatagttg acaaacatag atgaaatact 3204961 gtaaaatata attggataca tatattaaat atatgatgca aactggcaaa tacaatttat 3205021 aatagcacat tcacccaata ccaatcaagg tttgggttat ttatattatg cagaaaaaaa 3205081 ccgatttcac ttcgaaatcg gtttttttgc tattaattat ctaagcgaaa agaacggttt 3205141 ggcagcttcc aattaaacat ataggaacaa acccggcaaa caacgagcac gaaaaacaga 3205201 acgtataagc cgaacgagtt ccccagccag cccaagccga cgattaaacc gccgagcgcc 3205261 gcccataccg catagatttc cgctttcagc acaagcggtt tgcgcccggc aagaaggtcg 3205321 cggatgatcc cgcccccgct tcccgtcagc accgcagcca cgatcacggc actaagcgga 3205381 tggcccattt tgacggcata cagtgcgcct tggatagcaa aggcagcgag gccgatcgca 3205441 tctgataaat tgccccactt attccaatgc ttcagcagca gcttcggaaa cagaaacaca 3205501 attgtaatag ataaaagcgc gatttgaaag tacgctccct gctcccatag cgctgacacc 3205561 ggaacaccga tcagcaaatt gcggatcgct cctcctccaa aagctgtgac aatccctaat 3205621 atataaactc ctaaaatatc atattcctct tccatcgcaa caattgcgcc gctgactgca 3205681 aacgcaatga tgccaatcac actaagcagc tcccaagcca ttctgatgac tcccttttat 3205741 gtttgttaaa ttttctgacg acctctagat tttataatcg ctccagcgta aaatcaataa 3205801 cattttcatg agaaaaaaag ataaatttag agggaatacg gctattgctg atggacatga 3205861 gtttgcgaaa ttaaaaaagc gcccggcata cgcgggcgct ttttttgtta ttcagatttt 3205921 tcgcctttca gcaggcacat aaaaatgata atcaggataa aagcaatcag ggccaggaat 3205981 ggaatcgtaa taaaaccaaa ccagttaata tattggcccg agcacggcac gccgctgaca 3206041 catggcttaa tgccgctaaa gccgggcact ttttgctcta agtaatgcat gatcgaaatg 3206101 aatgccccaa taatcgccat cgggagcaca tattttttca ctcgtgtgtc cccttgaaag 3206161 gtggcgatgc ctaaaatcag gacgagcgga tacatgagga tacgctggta ccagcacagt 3206221 tcacatggaa taaactttct gatttcactg aaatacaggc tgcccagcat agcgataaga 3206281 gccacaaccc aggaagcata taaaaatacg attctatttt tcatattgtt acttcccttt 3206341 cagctctttt tctattgtct ctttgatttc atcataatcc gcaaaatttt tgatcacttt 3206401 atcattgacg taaatcgtcg gtgttgcctg tatgttcatt ttttgattaa ggtcagaatc 3206461 cttttccact tgagaagcga atgtttcctt atcaagattt tccttgagcg tctcaggttt 3206521 tatctttgtg gtgctttttg caagatcacc aaggaggcct ggggttaccc attcctgttc 3206581 cgtatccggc tgtttttcga acagcttttc atggaaatcc cagaaagagt cagggtcttc 3206641 cttccatact tcttcagatg caagagccgc taaccttgaa ccttttccat ggaacatgac 3206701 gttcacgaaa gaaaatttca catcgccctt atcaataaag tctttttgta tttttggaaa 3206761 gatgtcactg ttaaacacct tgcaagacgg acatttgtaa tctccgaatt ctactacagt 3206821 taccggtgca tcgtccttgc caagcacagg ctgccctttg atagacggct gtccggacac 3206881 cgcatcattg ccttgttccg ttttgttatt aatgatgaca atggctgcta gcaatacaac 3206941 aaccacaacc gtaaggatga ccgcgaattt cgcagaagac tgctgtttct ttttcactcc 3207001 gacacctcat cgttttaaaa ttaaaaaaga agcggatcgc aattgaccca cttctttatt 3207061 ttaacaagac aagcgctgat aagaaaaccc cgaaaaaatg aattctctcc gacaatttat 3207121 ttgtttttga gacgcatgac gcgcatggcg ttcgccacag caagcagtgt aacgccgaca 3207181 tctgagaaaa ccgcttccca catggtcgca attccaaatg caccaagaat gagaaagatc 3207241 gctttcacac ctaaagcaaa gccgatgttt tgccacacga ttcgccgtgt ccgtttcgca 3207301 atccgaatcg cttctgctat ttttgacggc tgatctgtca tcagcacgat gtctgcggct 3207361 tctaccgcgg cgtctgagcc aaggcctccc atcgcaaccc ctatatctgc gcgtgcaagc 3207421 accggcgtat cattgatgcc gtcaccgaca aaaatgagtt tttcactagg caaaagctta 3207481 gcttctaatg cttcgacctg cgcgacttta tcttgcggca gcagctctgc atatacctca 3207541 ccaatcccaa gctgttttcc gacggcttct cccgtttgtt tcgaatcacc cgtcagcata 3207601 gctgtctgtt tgatcccaag cgacttcaga tcagcaaccg cctgtgctgc gtcttccttt 3207661 atctcatccg ctatgatgat tgctccggca tagcgttgat ctacagcaac gtgtacgatt 3207721 gttccagcat tttcatccgg gacatcctca atttgttctc tttccatgag ctttttattc 3207781 ccagcaagga tctcagttcc atttaccttt gcaaaaatgc cgtgaccgga gatttcttcg 3207841 tatgactcaa tctcatcgga ggaaagcatt ttcccgtaag ctttacgcac agattcagca 3207901 atcggatgct gtgaatgaag ctcagcgtat gccgccgctt caagtaatct atcctttgta 3207961 aaaccttccg cgggtttgat ttctgtcact tcaaagctgc cttttgttag tgttcccgtt 3208021 ttatcaaaca ccgcgtattt gacttgattc aaagcttcta aataattgct tccctttaca 3208081 agcactccgg cctttgaggc cgctccgatt ccaccgaaga aaccgagcgg aatagagaca 3208141 acaagcgcac aaggacaaga aatcactaaa aagataagcg cgcggtacac ccaatcggaa 3208201 agcgcggcgc cagaaagaac aagcggcgga acaaaggcca gcaataccgc aatgatcacc 3208261 acagcaggtg tataatactt ggcaaacttc gtgataaagt tttctgtccg ggctttacgg 3208321 ctgctcgcat tctgaaccaa gtctaatatt tttgatactg ctgattcctg atagcccttt 3208381 gtgacttcaa tatgcagaac gccgttttga ttgataaagc ctgacattac atcttgtcct 3208441 tccgcagctt ttctcggaac ggactcacct gttaaagcag atgtatcaac catcgctgac 3208501 ccttgcacga ccttaccgtc caggggtatg ctttctcccg gattaaccac aatgatgtct 3208561 cctgtctgaa cgtcctccga cgaaacctgt tcgatgccgt tctttgtttt gagattggcg 3208621 taatcaggcc gtatgtccat taacgcacta attgattttc tggaacggct gaccgcggct 3208681 ccttgaaaaa gctcaccgat ttgataaaac agcataacgg cgaccccctc agggtattgc 3208741 tgaatcagaa aagcgccgat tgtggcaaga gccattaaga aatgctcatc aaacacctga 3208801 ccgcggatga tgtttttgac tgcgcggatt ataatgtcac cgccgataat caaataagca 3208861 ccgaggaaaa ggaaaaattc aatggttccc gactgaacca aatatgccgc tgcgccgaga 3208921 atgacagccg ccgccattct gatcagcata ttgaccattc gattacgata gccatcatca 3208981 gctgatttct ttatatgctt ttggcgaacc gttacatgcg gatcaattga tttcactttt 3209041 ttctctactt tattcgtgac ccattgctct tctttcccat cggctgagac agttaaggtg 3209101 cttgccgcaa aatttaccgc gcatccgtta atgcctttta tgcctttgac tccattttcg 3209161 atttttcggg cacaattgct gcaatccaaa ccgtccagaa catattcctg tttcactagt 3209221 ctcaccttac cttccgattt agggttccct cttcaaagcg tatcaatgag tattgtattt 3209281 attttatata tatgagcata tactcatata taagttacac ctattatatg ttgttttcca 3209341 agaaagtgtc aatgaaaaac aaaaaccggc atatagccgg tttttcattt tactttttgc 3209401 agacgaagag cattcagaac aacggaaacg gagctgaatg ccattgctgc tcctgctatc 3209461 cacggtgcta aaaatccaag tgctgcgatt gggatgccga ggctgttata gccaagcgcc 3209521 cagaataagt tttgtttaat gtttttcatt gtcaatctgc tcatgcggat tgcgtcggca 3209581 atgctgttca gatcgccgcg aataagtgta atgtctgctg tttccatggc aatgtccgtg 3209641 ccagttccaa tcgccatgcc gatgtcagct gtggcaagcg ccggcgcatc gttaattccg 3209701 tcgcctacca ttgctgtctg gcggccttct ttttgcaagc gggcgatttc cgccgccttt 3209761 tgttcaggaa gaacttccgc aatgatattc gcaattcccg cttccttcgc gatggcttct 3209821 gcggttctgc gattgtctcc tgtcatcatg atgacatcaa gacccaactc tttcagacgg 3209881 gcaacagcct tccgcgacgt atccttaatc gtatctgcaa ctgctactag ccccgctgct 3209941 tctccatcaa tggatacaag cataactgtt ttcccttcgg cctctagctc ttccatttgg 3210001 gcgagaagag ccccatgctc aacctgttcg ctctccatta attttcttgt gccgacgaga 3210061 atgctttttc ctccggcttc agccaaaatg cctgcgccga cttttgcttc aaagcgggta 3210121 agtttcggta tctcaagccc tttatctttc acgccagcaa taatcgcttc gccaagcgga 3210181 tgctctgatc ccgtttccgc tgccgctgca aattgaagca aatctttttc ttcaaaacgg 3210241 ccgaatggaa tggcatccgt cagacgcggc ttcccgtttg tcacggttcc ggttttatca 3210301 agaacaattg tatcgagacg atgtgttttt tctaaatgct cgccgccttt aaataaaatc 3210361 ccgaattcag cagcgcgtcc agatccagcc attatgctcg tcggagtggc aagaccgagg 3210421 gcgcaaggac aggcaatgac aagaaccgca atgaacttgc tgatcgcttc ggcaaaatcg 3210481 ccaggagccg cccaaagata ccaaatgaga aaagtgagaa ccgcaatccc caatacaatg 3210541 ggtacaaaaa tgcctgaaat ctggtcagcg agacgctgga tcggcgcttt tgacccttgt 3210601 gcttcctcaa caattttgat gatatgagaa agcgcagtat cctttccgac gttgacagct 3210661 ttaattttca gaaagccgtt tgcgttaacg gttgaacctg tcacgctgtc accaggattt 3210721 ttgtcaacag gaagactttc tcctgtaatc atcgattcgt caaccgctga acggccttca 3210781 accacttctc cgtcgacagg aattcgttcg ccaggtttga cgtaaacaat gtcattaaca 3210841 agcacttcgt cgatcgggat gatttgctcc tgtccgtctc ttacaacagt agctgttttc 3210901 gcttgaagct tcatcagctt tttaatcgca tccgaggaac ggccttttgc ttttgtttca 3210961 aacaacttgc ctaataaaat cagcgtcagc aaaatcgcgc ttgtttcata ataaaggccg 3211021 tctgtatgcc cgtgagagcc aatgctttga aaagttagat aaagactata agcgtaagca 3211081 gccgtcgtac cgagggcgac caatacatcc atattggcgc ttttatttct aagcgcctta 3211141 tacgcaccca cataaaacgg ccagccgatc agaaactgga ctggtgtcgc cagcgcaaac 3211201 tgcatccacg gattgagaaa tatatccggt acccaaatga atgatgtaaa tgtaaaatgg 3211261 ctcaccatcg cccaaagcaa tggaaatgac aggacagctg aaaaaatcag tctcgccgtt 3211321 tgcttccgtt cttctttctt tttagcagca gcctcactgt cctgttcacc cttcaacttt 3211381 agcttatatc caagcttatc taccgcttct ttcaaatcgc tgacagacgc ttcttttgga 3211441 ttgtattcga ccgtaactgt ttctaaagcg aagtttactg gtgcatttgc gacgccttct 3211501 attttgttaa gccgtttttc aatccgattg gcgcaagccg cacaggtcat gccctcaata 3211561 tcgaattcag ctttttctgt aacgacgtga tagcccagct tctctatttt ttcctgaatc 3211621 gctgcagtcc ctgtttcagc aggatcgtag attacatttg atgtttccgt tgccagatta 3211681 acatttgcat ccgtgacacc gggcatccgc ttcaggcctt tttcaattct ggcagcacat 3211741 gccgcacagg tcataccaga gacctgcatc gcgatttcct tttgttcact caacatactc 3211801 actcctttat atacacctgg ggggtatata aaaatgaaag aaatatcgcg cctccctaaa 3211861 ggcgcgatac cttgaatcac ttggctacgt catagccctg atcttctatc gcatccgcaa 3211921 tatctttgac tgatactttg tcagcatcaa acgaaacatc gactttaccc gcttccagat 3211981 tgacatgaac ggcactgacg ccgtccagtt ctcctacgct tgtttctact gctttgacgc 3212041 agtgctgaca agacattcct tcaacttgca atgttttttg ttccatatca attcctcctg 3212101 tttattcttt ctattttcat cctaccatac ccccgtaggg tattacaata aaaaacgctt 3212161 tatgattttg tgaacttttt aaatacgtcc aaaagctcag aaatggcctg ttccccgtct 3212221 ccgcttttga tggcatctgc tacacaatga tgggcatgat cctcaagcaa atgaagcgcc 3212281 acatttttca ttgccgcctg aacagctgaa atttgcacaa gaatatctac acaatatctg 3212341 tcgttttcca ccatgttttg aatgcctctg acctggccct caatccgctt aagccggttt 3212401 gtaatctgat ccttttcttt cgagctttta tggtttaatg ttttatgttc gttatgcttt 3212461 tccatgcgta cacctctgtt taatgatatt aattcccatt atactgattg tccaaacggt 3212521 tgtctaagca tgccgacgca aaaaatgaat cagttaggtt ttaccatttg atcaggaggg 3212581 tatatacttc tgttgataac gcttttaaag gggagaagaa aagtggatac gatcaaggtt 3212641 ggaatattag gatacggatt gtccggttct gtttttcacg ggccgctgct ggatgttctg 3212701 gatgaatatc aaatcagcaa aatcatgaca tcacggacag aagaagtgaa acgggatttt 3212761 ccagatgctg aggttgtaca tgagcttgaa gaaatcacaa atgaccctgc cattgagctt 3212821 gtcattgtca ccaccccgag cggccttcat tacgagcata ctatggcatg catacaggcc 3212881 ggaaaacatg ttgtgatgga aaaaccaatg acagcaacgg ccgaagaggg ggaaacatta 3212941 aaaagggctg ccgatgaaaa aggcgtatta ttaagcgtat atcataaccg acgctgggat 3213001 aacgattttt taacgattaa aaagctgatc tctgagggat cccttgaaga tatcaataca 3213061 tatcaagttt cctataaccg ctacagacct gaagttcaag cgcggtggcg ggaaaaagaa 3213121 ggcactgcca ctggtacgct gtatgatctc ggctcccaca tcatagacca aaccctgcat 3213181 ttgtttggga tgcctaaagc cgtgactgca aacgtgatgg cccagcggga aaatgccgaa 3213241 acggttgact attttcattt aaccctggat tatggcaagc ttcaagccat tctatacgga 3213301 ggatcaatcg ttccggcaaa cggacctcgt tatcaaatcc atggaaaaga ttctagcttt 3213361 atcaaatatg gaattgacgg acaggaagac gcactcagag cgggaagaaa accagaggat 3213421 gacagctggg gtgcggatgt tccggagttt tacggaaagc ttacaaccat tcgtggctcc 3213481 gacaaaaaaa cagaaacgat tccatcagta aatggctcct accttactta ttaccgtaaa 3213541 atagcggaaa gcatacgaga aggtgctgcg ctgccagtca ctgctgagga aggtattaat 3213601 gtcatccgca tcattgaagc cgcgatggaa agcagtaaag agaaacgaac cattatgctg 3213661 gagcactaaa acaaaagcct ccccaaataa ggggaggctt tttcattaga atgtttttcc 3213721 tgcttctttc gcacgcgcaa tcgcgtcttc tttgatttgc tgtgctttat caggctccgc 3213781 attatgtccc tctacgaaaa tgccatcgaa tgatggtacg ccgaagaagt tcatcatgat 3213841 gccgatgtag cggtgcccca tttccatctc agccgcaggg ccttctgaat agtagccgcc 3213901 gcgcgcttgg atatgaattg cttttttatc agttaacaag ccgacaggac cttgttctgt 3213961 gtatttgaat gattttcctg caacagcaac agaatcgaga tacgctttca tcactggcgg 3214021 gaatgagaag ttccataaag gagtaacaaa tacgtactta tcagctgatg caaattgatc 3214081 gctaagctct cccaaacggc ctactttcgc tttttcgctt tcagaaagct cttcaaagcc 3214141 tgtacctgac tgaagctttc cccatccgct aaatacatct gcgtcaatgt gcggaatgtt 3214201 ttctttgtac aaatcgatat gtacaacttc atcatttgga ttcgcttctt tgtaagattc 3214261 gataaatgct ttacctgttg ccatactgta cgaagttgct tcgtcatgtg gatgagcagt 3214321 gatatataat acttttgcca tttttaccag ccctttcgtt tttaaaaatc acacatcaat 3214381 tattatcata cagatgcata atgattattc tgtctctctt agactttatt atagagacaa 3214441 agaaatttac tttcaagtaa aacatctcga attaaagatt atttaacttt cccaaacagc 3214501 ttacttttca aaagctgttc tcaagccgga atacagcgcg gacaattctt tactgatccg 3214561 aggataatga gggacatgcg gcacttgaat atccgcaggc atccttttca tgataaagga 3214621 ttgctcagcc tgttcaaaaa acgcccgcag ctggttgatc tcttcatcag aaaacggagc 3214681 agacggacgg cggtgagctt gcgccgagag caaatagtac cctaagtgct gagcaccgga 3214741 aatggcaggc cagagcgcat ccgcattcgc gtgaggaaac tcgccaagcg ccttgtcata 3214801 cgcatcccga agcctgacaa gactcaccct taacttgtgt tcgtcggcaa tttgcccggt 3214861 taacagtttc tccataaact gcccttccag ccggatgaca ttccgcacaa gttctggcag 3214921 ccgcttggtt gaaaaccgcc gccacaaaag cattgttccc aacagcccga tcacgctgcc 3214981 gacagctaca tcagtcagcc tcgctatcat aaaataaccg gcgcccgccc cgccatgcat 3215041 actttctgtg ataacaagcg catttgcggt taaaaaggga acagccagcg cataattgcg 3215101 gacgatcagc atctcaagaa gacattgcag cgctgcaata caaaacgcaa tataaacacc 3215161 gcccggctta aaaaacagga ttgcgcctgc cagtataaca ccgatcaccg ttccggccga 3215221 acgctgaata gccctgtgaa gcgtaaaaac aacagtagtg ccaagcatga ccgctgctgc 3215281 cgaaagcgga atccaatagg agcgtgcaaa gccgaatgcg agggcaaaca tatcggcggc 3215341 aaacagaaca attccgtact ttaacgctct aatcaaaact ggagacttcc agtcaaaggc 3215401 atttctcaaa aagtaaaaag aggatggcag gcggcttggt tccccgtcaa gctgcttatc 3215461 aaaacgtcct gaagcgatat acaaaacctc attgatttct tcaaacagct tccgcctagg 3215521 ctcagattca ttttcattaa tctgaaacgt attgaaaacc cgtgcattcg caagcatatc 3215581 tccggtttgg cgaagtgcct tttcaatctg cgcggtctct ctgtccggcg tttcagctga 3215641 aaaatgaata atggcaataa atatgtcgtc agctttctca aggaggcgaa aaaatcgttc 3215701 atcatgccgc gattttttcc gtctgttccc tttcccaaga accgtttggc gggctgttct 3215761 aagcatgagc accgtctgat gctgtgcgtt atgaaaacct ggcgttccga cggctgaaag 3215821 acatgcagcc agctgatgat atgttttttg cagcaccgct ccctccggtc catgtttgtt 3215881 ccataaccag ccgattaaag cgatacccat ggcgaaaatg ccgccgagaa acgtcagtcc 3215941 cgctctgaac agcgcttgtg aaggatcggc cggcagcccg gaactgacta aaaaggcaag 3216001 gacaaaaaac atcggcgcag ggccttgaat gccgagcgcg ctaaaaataa acatcgccgc 3216061 tgcaccgatc agccccaaaa cagccgccat catccaaagc atcccggaca aaagcgtccc 3216121 taaaccaaat gagagggcga tcccaataga aaccaagagc agcttcaagg cgcgcttttt 3216181 gtacgattca ccgcccgcat ataaataaac aaagcctccg atacttgcaa ttaatccgta 3216241 atccgtgtga cctgccaatg caccgaccag cacaggaaac cctgaagcga aacctgatcc 3216301 gatagccttt ttccaaggaa atggatttgc atgaatgcga aaggcatcct tcacgatagg 3216361 catgattctt tgattgttcg cagcagtttt gttcatttga caaaatcctt ttcaatgaat 3216421 gtgtagaact tttccagttt cttcgcttta gtatgcccaa aaacgcggtt agcttctcaa 3216481 ttggtgcgca cgataaaaaa acagagactt ataccgtctc tgcttcatta catcagttta 3216541 ttataaaagc ggcacctgtc aggactgttt tgtccttctg ccttccttca agagcaggtg 3216601 aataaaaaat aaaggataaa tcaatagata cccattaaac agccaccaca caagatcaaa 3216661 gtcactgctg aatgtccaga atgatagcgc ctgcagacct gaacaacagg tcagcacaag 3216721 agaaatcagc gccatcagct tccagtcagc acgattcacc cgctgtaggt acaagctgta 3216781 caaccctgtg acagaaatca ggatatccag cggaaaaaaa gaccagttcc aagcgatcat 3216841 aaacggatgg tcatgatgtt taaaagccca gctttccggt atgagcgaaa atccggctga 3216901 cagccagtac aagataaaac cgatatcagt cacgagaaaa aacagcttca tatatctcat 3216961 ttgtactgcc cgcttttatg taccggctca gacaccgcaa catgctcgat caggtttaaa 3217021 gacacaacac cggcaataat caatccaatt gaaatgactt tcatgacact cacatgttct 3217081 tgaaaaaaca aaaaaccaac gactgtaatc aagacaattc ccatccctga ccatacagca 3217141 taagcaactg atacatcaat ggatttaagc gtaagcgtca gaaagaaaag actccctcca 3217201 taaaagaaaa tcaacagcaa actgggaata agctttgtaa aaccagacga tagcttcatg 3217261 ctgacagttc ccgcaacctc aaacaaaatc gccaagcata gaaacaccca attcatgtgg 3217321 catcagcctc ctcatcagct gttataccgt taaacaaaac atctacaatt gattcaagta 3217381 cctctcctgt cgtgaactga tgtttcagcg gatattcagg gtcatacact tgattgatgc 3217441 tccctatata catgtgaaca aacaggtccg gattgatgtt tctgattctc ttttgctgtt 3217501 tgcactcatt taataatgct aggacaatcg cccattcttc cttaataaac gcgtctaatg 3217561 taagccacgc atcgtaatgg tatttcttta gttcatttaa taatcccatg ttcagcagtt 3217621 ccatcccctg cggaaggctg atcagcattt gtttcacctt ttcgagcaca tttaaacttt 3217681 cattttcata gatgtctctt tctatttgct tcatttcagc tataaattgt tcgacaaccg 3217741 cctcaacaag ctgatcttta gatgaataat atgcatagag cgtccgcttg ctcgttccca 3217801 gcgctgccgc caaatcattc atcgtaaatg aaaatccttt ctgcttgatc agccggaagg 3217861 tttccgccag aattctttta tccatattaa tcccccgctt tcggtaccaa gaaaactatt 3217921 tcggtaccaa tattatacgg cagaaattta tggaaatcaa caatatataa aaaaacctct 3217981 cctattggga gaggtttaaa agacactgcg gaccaaaccg ccgtccgccc gaagtgccgc 3218041 gccattgatc gcagaggaaa gcggactgct taaaaatgta acgaagtggg cgatttcttc 3218101 cggacggatc agtctttgaa taatagatgt cggccggttt tctttcataa aacgtgcctc 3218161 agcttcttga acagtcaggt tttcaccagg atacagcgag ttcagcatgg tttccacacc 3218221 ctctgttaag gtagagcccg gcatgacggt gttgactgtg acattcgtgc cggttgccag 3218281 ctccgccaaa ctgcgggaaa tggacagctg catcgttttt gtcgcactgt aatgggccat 3218341 ttcctgtgac ggcataatcg ccgcttcact ggcaatgaaa atcacacgcc cttctttttt 3218401 ctctatcatg ttatgcaaat acctgcgtgt cagccttaca ccgctcataa tattcacttc 3218461 aaaaaaacga aaccattcat cgtcgggaat atcaaagtac tccgccggtt caaaaatccc 3218521 taaattgttg accaaaatat caacctctgg atatgcctga aacagctcat tgcagccttc 3218581 ttctgttccc aaatcaaatg cagccggata aagaaccgct tcagcatgtt gtgttttcag 3218641 ttcatctatc gtttgattca ctttctcttc ccggcgtccg ttaatgatca ctgccgcacc 3218701 ttcttcagct aacgaagagg caatagcttt tccgatccct gatgtcgaac cggtcaccag 3218761 tgcggttttt ccttgtaaat tcagcttcat tattcatccc tccgtttttg attcctctta 3218821 tttattgaca gaaatctgat tggtgaaaca tctgctctgc aatcagtatg aaacagctgg 3218881 gattgaaatg gaagtacgca ctttttggtg cctgtggttt ggagaaaaaa taaagcagaa 3218941 cctcttaaga ggttctgctt tattgtcagt atgtatggag acggtgggag tcgaacccac 3219001 gtccagaaac atcgattact taagcgtcta cgagcgtagc ctgcatattt atggtttcac 3219061 tcatcttctt gcctgcgggc gggccttccg agagctagtc tgttcatctc ttcttacgtt 3219121 ctcagacggg aacgcaagcg tagcctactt ggatgtgctc ttcacagaca cataggcaat 3219181 gtcaggaaga gctcgctgcg cttattaggc agctaatgct acgttttggt taaaactgtt 3219241 agttttgcca gttatattta agtgcgtgtt tacgagatcg cctctcggct cgcagctcaa 3219301 gctcgatcca tccctgtcga atccgtaacg tccccttggt ataagggaaa tacgggagaa 3219361 aatatcaagc tctcactcaa actggctata gtcttattat aacatgatca cggctctttt 3219421 caattgtcaa atccttcaaa tgaatggcgt cgtgatctga tcgtgaacac agtatagcac 3219481 aggcctgatt ttcgaatcaa gcactatgcc tttagaagcc tttttgactg tctctgaacg 3219541 ctctttcgat ttcccgcttc gcgtccttgc gcttcagatc ttcccgtttg tcatagttct 3219601 tcttcccttt tccaaggccg agaagcactt tggcaaagcc gttttttaaa tacagcttca 3219661 gcggaacgag agaatagcct ttttcctttg ttaacccgat cagcttatta atctccttgc 3219721 ggtgcattaa cagctttctt gtccggagcg gatcgtggtt atagcggttt ccctgctcat 3219781 atgggctgac gtgcatattg tggagaaaca cttctccccg ttcgattttg gcgaaggaat 3219841 ccttaaggtt tacgcggccg gcgcgaatcg atttgatttc ggttccttgc agaacgatgc 3219901 ctgtttcata ggtttcttct ataaaataat cgtggttggc tttcttattt tgagataata 3219961 cttttcctga cccttttggc atgccagaac ctcctctctc taaggaaaaa ctgtccacct 3220021 tttgcgatac gctctatttt accaaatgtc acgtaccgct acaatgaaaa gctgtttccg 3220081 aaagaaagca aatagagcgc tgcggcccta tttgctggtt gagctgctat ttcttctttt 3220141 tccgtttctg tttcggagca ttctggaagc cgcgtttttt ctttttcttc ttcggcttag 3220201 tgaaccactc ccctttttcc tcagacggag ctggagaaac aggtgtattg gtgctttgaa 3220261 cacgttttct ggcaggcttt ccgcgttttc tgctccggct gctgtccaat tctctcggac 3220321 gccgcggagt gcctttcatg ccgacaattt caaagtcgat attgcgctca tctttattga 3220381 catcgacaac cttgactgtg atttcatccc cgatgcggaa gacgttgcct gtccgctcgc 3220441 caatcattgc gaaatgctgt tcgtcaaagc ggtagtagtc atctgtcata aagctgacat 3220501 ggacgagtcc ttcaattgta ttcggcagct cgacgaacat tccgaagttt gtcacagagc 3220561 tgatcatgcc gtcaaactct tcaccgattt tatcaagcat gtattccgct tttttcagat 3220621 catccgtctc acgctcggcg tcaactgcac ggcgctccat agatgatgta tgttcggcga 3220681 tatccggcag gcgttcagcc cacttttcct gtgtcgcttc atcgaccttg ccgttgatca 3220741 aatacgttcg gatcagacgg tgaacgatta agtccgggta acggcggatc ggtgatgtga 3220801 aatgcgtata gaattccgtt gacagaccga agtgccccaa gctttgcggg tcgtatttcg 3220861 cctgtttcat cgaacggagc ataacagtag atataaccgt ttcctctggt ctgtcacgca 3220921 cagcgtccag aatgctttgc agcgcgcgcg gatgaatatt ccccgccgtt cctttcacca 3220981 catagccaaa tgtcgtcaca aattctaaaa acttttgcag cttttcagca ttcggctctt 3221041 cgtgaatccg gtatataaac gggacattca tccaatggaa atgctccgca actgtttcgt 3221101 ttgctacaag cataaattct tcaatcagct tctcggcgac agagcgttct ctgatcacaa 3221161 cgtctttaac cgctccttcg tcatcaacaa gcacctttgc ttctttgaaa tcaaagtcaa 3221221 cggcgccgcg gtccatccgc ttatcgcgca gaatttgagc cagacgctcc atgtctttga 3221281 acatcggaac aagaggctcg tatttttgtt tcagctcttc atcatcatca acaagaattt 3221341 tattcacatc tgaatatgtc attctttccg ttgttttgat gacactttgg aagatctcgt 3221401 gctctgtcac ctgtccctga ctgttaattg tcatttcaca agaaagcgtc aggcggtcaa 3221461 cctttggatt taaggagcag atgccgtttg acaatctgtg cggaatcatc gggatgacac 3221521 ggtcaaccag atacacactt gtccctcttt caagcgcttc tttgtcaatc ggcgagtttt 3221581 cggttacgta atggctgaca tcagctatgt gaacgccaag cttgtagctt ccatcatcaa 3221641 gcttcgtcac ggtaactgca tcatccaaat ccttcgcatc cgcaccatca atggtgacaa 3221701 tcacctggtc acggagatca cggcggtctt tcagatcttt ttcatcaatc gtgtcaggcg 3221761 tacttgatgc ctgttccatc gcgtcagctg gaaattctcc cggcaggccg tgcttatgaa 3221821 tgaccgataa aatatcaatg cccgggtcgt ttttgtggcc gagaatggtt tcaacctcac 3221881 cctctgcgtt catgcggcct tcaggatagc tcgtcagctt gacaacaacc ttatgccctt 3221941 ccgcagctcc atttttccca tttttcggaa tgaagatgtc actcgtgatt tttttgtcgt 3222001 ccggaatgac aaagccgaag tttctcgttt ctgtatacgt gccgacaacc cgctgaatcg 3222061 ctctttctaa aatccgtatg acggttcctt cctgcctgga gccgcttgat tgtgagttca 3222121 gacgcaccat gacgatatcg ccgttcattg ccgtatttag ctcattaggc ggaataaaca 3222181 catcacttaa cgacgtatcc tcaggcagca aaaaggcgaa tcctttcgca tgggctgaaa 3222241 tctttccttt tattaaattc atcttctccg gaatgccgta gcggtcgctt ctcgtccgta 3222301 cgataagccc tttttcttcc aaggcgacta acgctttgac gagctcttta aactcctcgg 3222361 cttccgtaat atttaacatc tcctcaagtt cctgaacggt cagaggtttg tacgcctctt 3222421 ccttcataaa cgagagaagc ttttccataa atgcttcttt ttccattatc cgacctcctg 3222481 ttgattacca atcgagcttc tctaaaaatt catacacatc ctgatggacg aggtcacgtt 3222541 ctttgtcgag tgtaatgaca tgccctgatt cctcgtacca tttcagctgt ttatcatcag 3222601 tttccacttc gttgtaaata atattggcgc tttcggtatt aatcatgtgg tcatgacggg 3222661 cctgcaccac aaatgtcggt gaataaatca tatcgacatt attccgcaca tcagcaatta 3222721 agtcttgcag cgccttgagg gtattcatcg gcgttttttc gaattctttc atttcctctt 3222781 caatttgctc cgggcttttc ccctcaaact ttttgtaatt gcgagcgtat gaaagaacgc 3222841 cttgatacat gacctcttca ctcttaatat gcatcggtgc gcacattggg acaattccct 3222901 ttatgggtac agtgtaaccc aatttcagcg aaaaaacccc gccaagcgac agtccgcagg 3222961 cagcaatgct ctcataacct tcagatttta aatattcata gccatccatt acgtttttcc 3223021 accagtcttc gggccccgta tgtacaagtt cttcaggcgg gacgccatgt ccttcatatt 3223081 gaggcgcgtg gcacgtatag ccgcgttcat tcaaatatcg tcccagcatc cttacatccg 3223141 ctgtatttcc tgtaaagcca tgcagcaaaa gcaccgcttt gtctccgcct ttaaatgtaa 3223201 atggttttgg tgtcacaact ttcatgctca tgtctccctt tctatctgca cgatcatttt 3223261 agttttccac agtttaatca gaaaaaaacg ttttgaatat catccagaaa cgtgaaaaag 3223321 gcctgacttc acatcagacc ttatacaaac attgccctat aggatataag caagcgcaat 3223381 cgttaacacg aaaaacaaga ctgccagcac taccgtaatg cggtgcaaaa ttaaatcaag 3223441 acctcttgct ttttgtttcc cgaagagctg ctccgctccg cctgaaatcg caccagataa 3223501 tccggcactt ttactggatt gaagcaaaac gacaataata agtgcaatgc tgacgataac 3223561 caataaggta atcaaaactg cgtgcatccc atacacctcc agactcactg gctacattac 3223621 ttctatttta catgaaaagg gttggcatgt cacgctgtat cagacgccaa aaggccggat 3223681 aagacgtttt atcttggtta ccctattcat atgaaaaggt caaaggagaa aagcgatgcc 3223741 gcttatcagc atagacagca ggaaacatct tttttatgaa gaatatggac agggaatccc 3223801 tatcattttt atccacccgc cgggcatggg acgaaaggtt ttttattatc agcgccttct 3223861 atccaagcat ttcagggtga tttttccgga tttaagtggc cacggtgata gtgatcacat 3223921 cgatcagcca gcgtctattt cctattacgc aaacgagatc gcgcaattca tggacgcttt 3223981 gcacattgat aaagctgtgt tattcgggta ttctgccgga ggcttaatcg cgcagcatat 3224041 cggcttcacc cgcccggaca aagtgtcaca ccttattctg tccggcgcct accccgctgt 3224101 tcataacgta atcggccaga agctgcacaa actgggaatg tatctgcttg aaaaaaaccc 3224161 cggtttgctc atgaaaatcc tcgctggcag ccacacaaaa gacagacagc ttcgcagcat 3224221 attaacagac catatgaaaa aagcagacca ggcccattgg catcagtatt atctggattc 3224281 gcttggctac aactgcattg aacagctgcc ccgcctagaa atgccaatgc tgtttatgta 3224341 tggcggcctg cgggactgga cctttacaaa cgcaggctat taccgaagat cgtgcagaca 3224401 tgccgaattt ttcagattgg aatatcaggg acatcaattg ccgacaaaac aatggaaaac 3224461 gtgcaatgag ctggtgacag ggtttgtgct gacacatcat tcataggaat agaaaacgct 3224521 tggcttcctt gcgttttttg ttactttatt gacttttgtc aacgaaatca tagtaaaaaa 3224581 gatcctcaaa tttcaaatta aaatagtgaa gcattttacc aatcacaagc tgccccggcc 3224641 ttctttctcc attcagcacg cggctcagtg tggcgggtga gactccgatt tccagcgcaa 3224701 gctgattaag ggaataatcg ttattaacca tatactgcaa gacataatca cgtctaatct 3224761 gtatcttttc tactggcact ttcctcacct tccattcctg aaaaactttt ttctatactt 3224821 ttacattacg gcttatgtta acttttgtca atacatttcc agtctaccta ttccctttag 3224881 tcaataaaca tactaaaata tgagtaacag tgagggacgg ggtgagatat atggaaagct 3224941 ttggcgaaca attacgggca ttgcgtgaag agagaaagtt aacagtcaac cagctggcga 3225001 cttattcagg cgtaagcgcg gccggcatct ccagaatcga aaacggaaaa cggggcgttc 3225061 ccaaacctgc caccatcaaa aaactggcag aggccttaaa aattccttat gaggggctta 3225121 tgtacaaggc tggttacatc gaagaagtgc atgaagccag ggccccttat gaaacgaagt 3225181 gcaagctgct tgaaaaagcg gaggcctatg acctgaaaaa ccttgcgctt cttgagaacg 3225241 aaaagtggca atatctcaat aaagaagatt tgctcatgct ggatcattat ttttcgttta 3225301 tttcagatga agcgaaaaaa cggtctgctg atgactgact cttgatagaa atgtgaggcg 3225361 atagaccatg tcaccgttcg gacagcaatt acgggagctg cgccgcgccc gcaaactgac 3225421 agtgaatcag cttgcggtgt actcaggcat cagctcggcc accatttcaa aaattgaaaa 3225481 cggcaaacgc gggacgccaa aacccgccac gattaaaaaa ctggcagccg tcctgaaagt 3225541 gccgtacgaa aacctaatgg ccgccgcagg ccatattcag gcctttcctg aagaaatccg 3225601 cgaagcatct gaaggctatc aatccgttta tgaaatttac cagacggctg tcacacgcgg 3225661 agcggagcac ctcccgattt tcaatagtca aaaatgggaa catctctcaa agcaggatat 3225721 tgaaaatctc agcaaatact tcgatttttt gtcttcagaa gcaaaaaaac gcgcctcttc 3225781 ctcataatcc cctgtttctc tttctatatt ttatcaatca cgcttgcatg ccctccctcg 3225841 ttatttgcgt tataatagtg acagacgagg tgaaaagtat gaaccaatca gaaatgtgtc 3225901 ctagatttga aaaagcagtc gacatcttaa gtaaacgctg ggtcgcttta atcgtatttc 3225961 agctcttgaa cgggtcgcag cgatttagcg aaattgaagc agcacttcca aatctaagcg 3226021 gcagagttct gtcagaacgg ctgaaagaac ttgagcttga aggagtagtg aagcgggatg 3226081 tcatccctga aactccggtt cgcatcgaat attcattgac tgataaagga aaggcactag 3226141 cacccatatt aggtgagatt tctaaatggg cgactgaatg gattgaccct tcctttcttg 3226201 actaattgct aaaatggttc tgatctcaaa gacgagaaaa gaaccgtttt ttattttcca 3226261 ggtgaaaaaa agatatctca gccgatatat agtacatcca cacattacgt ttttaaagga 3226321 gaccactata tgcgactgac gatttcccgc aaattcagcc tggtattttt gacactgatc 3226381 ctgatcaatt tacttgtagg cggaataggc gttcttaata tgcagcatat cattcaaaaa 3226441 acagatgaaa tcaacacaaa atggattgac ggcatcaaag gaatcacttc aattaattat 3226501 gtaaccgagc acctgtcttc taaagaaaag gactttctga tttatacaga caaaagtaaa 3226561 atggatacac ttgatcaaga aatgaatcaa atcatggaag acattaacca aaagctcgat 3226621 aactacgaaa aaacgatctc cactgataaa gagcagaaac tgttcgagca gcttcaaact 3226681 aaagtgaata cctatatgga tattcatgcg caaattatcg aaagcggccg cacgaatgac 3226741 atggacaaag caagaggttt attggttcag actgaggcca gctttgagga tatgaaaaaa 3226801 acaatcactc agcttgttga cttaaatcaa gaaggcagca acacagcggt aaaagaaacg 3226861 aaggccgtct atcataaagg gctcatttac actgctttgc ttgtggcagc atcaatcctc 3226921 atcagcattt tcatctggct ttatatcacg cgaaacattg taaagcctat cattcgcatg 3226981 aaggaatctg ccaatcatat tgccgaaggc gatttgtcga acgatatgga ggccctcaac 3227041 tcaaaagacg agctgggtga tctgaatgaa gcgctgcaaa aaatggtagg gaatctgaga 3227101 gatattgtcg gatattctaa agacatatca agccgggttc tttcttcttc acaggtgctt 3227161 gcaaccgcaa cgaatgaaac aagatccggc agcaaacata ttaccgagac gatgaacgaa 3227221 atggctgagg gctctgaaca gcaggcccaa gacgcggtga cgattgccga atcgatgaat 3227281 gagtttaccg aaagcattga taaagcctat aatcacggca tcacaatcag cgatacgtct 3227341 caaaacgttc tcgaactcgc ggtaagcggg aacgaaaata tggctacgtc attacagcaa 3227401 atgaaaacca tccatcatat tgttgaagaa gccgtgcata aagtgagatc actggaacag 3227461 cattctcagg atattaacaa gctcgttcag gtcatcaacg ggattgccga gcagacgaat 3227521 ttgctgtccc ttaacgccgc gattgaagct gcccgcgctg gagaaagcgg caaaggcttc 3227581 gccgttgtgg cagaggaggt cagaaagctg gctgacggcg tttctgattc cgtgcaggac 3227641 attacccgga ttgtaaacgg gacacagcag gagatccaca ctgtcattac gtacttggaa 3227701 agcagcttta cagaagtcga aaaaggaacg gaaaacctga cagacaccgg acaggctatg 3227761 cagcatatca aacaatccgt cacccatgtt gcagacagca ttaaggaagt aacggatggc 3227821 ttgaagcagt taacaaacca atcgattacc atcaatcaat cgattgaaaa tatcgcttct 3227881 gtatccgaag agtctgccgc cggcattgaa gaaacatttt caattaccga gcaatccgcc 3227941 cattcgatgg atcaagtgct tctaaatgct gaagagcttg agcagctggc caatgagctt 3228001 aatgagaaga tgggtcagtt tacgatttaa agagaaaaaa gaggctggac tccagcctct 3228061 ttttctattc tatgcagctg attgaacatg tttcgccccg gttctttttt tcttcaccgg 3228121 acttaatgcc cgctccagcc aagccatgag caaatccgcc cctaccgcca tcaccgcagt 3228181 tggtatcgct ccggctagaa taatcgcagt tccgtttgtt gcgtttgagc cgcgtacgat 3228241 catgtcccca aggcctccgg caccgacaaa tgtgccgatc gctgtaattc cgatggcaat 3228301 gacgagagcc gtgcgaaggc ccgccataat gacagaaagt gcgagcggga gctcaaccat 3228361 tctgagcact tggaatttcg tcatgcccat tgcttttcca gattctaagt aggcatgttc 3228421 aatactgata atgcctgtgt acgtgtttcg aataatcggc agcagggaat acagaaataa 3228481 tgatagaatc acggtatttg cgccgagccc cataacaagc attaagacgg ccagcatagc 3228541 gagcgccggg attgtttgaa taacgtttgt tacggcaaac acccaggctg acaaacggcg 3228601 aaaatgcgcg atgaggattc cggccggaac cccgacgaca gcggcaaata aaacgccgta 3228661 agccgacatg agaaagtggc ggccgaattc atccatgacg taactgccat tctgcgcgta 3228721 atacgtcatt aactgttcaa gcacgttcat tgacctcttc cccctttcac gattcgaaat 3228781 agcgatgttt ttctaaatat tccttggcaa cgacagacgg ttctttgaga ttgccgtcga 3228841 cttcatagtt aagctcctgc atcgtggctg tgtcgatttt tccgagcatt ttcttgatga 3228901 tgccttcaag ttcaggatgt tctttgagca ccttttccgg aacaaccgga gagcagtcgt 3228961 acggcgggaa aaattgttta tcatccttta gcattttgag accataggac ttgattcttc 3229021 catcggttga atacgcaagc acaatgtcca tttttccgct tttcaccgcg tcgtacacaa 3229081 ggccgatctg catcggatac gtgccgccga atgtcatgcc gtaggttttc gtaaaatcct 3229141 gatagccgtt tcctttgagc ttcatccaat agttatcaac gcccagcttt aattgcggcg 3229201 cccatttttt aacgtctgat acggtctcta aatggtattg gtcggccagc tccttgctga 3229261 ctgtaaaggc atatgtatta tcaaacccgt aggagtcata ccactttaaa tcatatcttt 3229321 ttttaaactc ccgctgagta agcgccagcg ctttgtccgg atctttttca ggttccattc 3229381 tcaacgtgcc tgtcagcgcg tctcccgtat atcttgtggc cgcaatgtcg atttccccgt 3229441 tcattaaagc ctgctgctgc accgcgttgg agccaagatt tttaatcgtt gttgttttga 3229501 gatcagtatg gtgttcgatc aactggccaa gcatgctggc gatgatttct gattcgctca 3229561 tgctttgcgc gccgatttta atggtctggt ctgcagcagc gctgagacca ggaagcgaac 3229621 agccgctcag cgtcagcgtt gccgcaagtg ctaaacctat cattaatttg agatattttc 3229681 ttttcatgag ccgcctcctt atgacaattc cttcaatctc tgcatgccgg caggtgtcag 3229741 ttttcgttca gcaactgcca gcacataatc aatcacaatt gccaatatcg tgacaggtac 3229801 cgcgcccccg atgatatatt ccggctgata taaattcagt ccgataaaaa tgtaatcacc 3229861 caatccgccg cctccgataa aggaagcaag cgtggcccag ccgattaagt aaatcgtcga 3229921 tgttctgatt cccgccatga tcactggtgc ggcaagcggc agctccacca agcggacttg 3229981 ttcagccggc gtcattccta ttcctttacc agactcgagc agatttttgt tgacgccgcg 3230041 aatgccggta tacgtgttgc gaagaatcgg caatacggaa tagaaaaaca aagccacaat 3230101 ggccggaacc ttccctacac caaggagcgg gataaaaaaa gcgaggatgg ccagactcgg 3230161 cagcgtctga atgatattga caatgccgat aatggtgccg gctccttttt tcattctggt 3230221 aagcacaacc ccgaggggga cggcaaccag cacacctaag atcacagcaa tgagcgatat 3230281 cgtaatatgc tcgtatgttt tataaagaag ctctccccca ttggtttgca aaaattgaac 3230341 aatatgatgc atgacttatc gcccctccct atgacaatgc tgcgagctgc ttttcttctc 3230401 cccagaggga gtcatacacg atgtcgacca gacttgccct cgtcacaatt ccgatcaggc 3230461 gtcggtcttc atccacaacg ggaacatatt tgacaccccg ttttaaaatt ttgcggaccg 3230521 tgtcgcgcag cagtgtgccg cccagtactg tgtatatatc ttcatgtaaa acttcactga 3230581 cgagattggc ctttttccgg cattgatcaa tgatttcaac atcgacatag ccttgcagaa 3230641 cgcgctcgtc attgacgacc agcaatgaat cgacccgttc ctgcctcatc agctgaatgg 3230701 cctcagaaag cgttttatcc gcggtgatcg ttacaggctg tgtgttcata atctggtcaa 3230761 cccgttcaac atccgggctg gatgactgaa tcagccgctc cttgccgata aattcctcaa 3230821 caaattcgtc tgccggattt cttaaaatgt catcgggcgt tccaacttga acgatttctc 3230881 ccgcttttaa aatcacaatc cggtctgcca gcttaatcgc ttcatccata tcgtgggtaa 3230941 caaatacgat ggttttatgt aaggtttttt gcagtttttt aaattcttcc tggagggaat 3231001 ccctcgtaat cgggtcgagt gccccaaacg gttcatccat taagataagc ggcggctccg 3231061 cggcaagtgc ccgtaataca ccaattcgct gctgctgccc cccgcttaat tcatgagggt 3231121 aacggtctac atattctggc cccatatcga ccaattttaa aagctcacgc gcccgctctt 3231181 tccgctgctg ctccggccat ttcagcagtt ttgggacgag tgagatattc tgctgaatgg 3231241 tcatatgggg aaacaggccg atctgctgaa tcacatagcc aattttgcgc ctgagctcta 3231301 caggatcctg gtccatgatg ttttcgccgt caatgaaaat cttcccggcg gaaggctcaa 3231361 ttaatcggtt aatcattttc attgttgtcg tttttccgca gccgctcggc ccgataaagc 3231421 agataaattc gccttttgca atcttaagat ttacgttgtt cacggctttt ttgccgccct 3231481 tgtatgtttt cgagacattt tctaatgtca gcaaacatcg cacctccaaa attaagttta 3231541 ttcaatttgt tcagtttaaa tttaattttt cagacaattg aatgcttccc attatagaat 3231601 aaagtttata aaataaaaag tttacaattt gttcatatta tttataaagt atgtgtaaac 3231661 gctgatttac ccgcattgac gtgtgttgat ctccttattg ctccaatttc ctgccaaatt 3231721 ctcttttgac agcattttcg ccgtatcaaa aatgtggtat attgacatcg gaattgttag 3231781 ctgaaaggat gaaaccgttg gagaaagatc cgttaacgat cattgaacaa gccgaggacc 3231841 attttataga aagaatcgcg gaaaacatgc atgcatttgg aatgccctct accgtcggac 3231901 gagtgctggg cattatttat atgaatcgaa aaccgatgac gcttacggaa ttatctgagg 3231961 ccaccggcat gagtaaaaca cgtatgagcc aggtagtgcg ggaaatgctt gatgccaaca 3232021 ttgccgagaa ggtattcgaa aaaggcgtgc gaaaagattt atatgaggtt gagcaggact 3232081 actatcaaac atttatcacg ctgttttcag ccacctggag caaagtcgtc agcaaaaaca 3232141 aaatgatgca taaaaaactc aatcgggagc tgcttagcgt gttggatgaa gagcttactc 3232201 ctgaagcgga agaaaaagtg aatgagctgc tgaaggaatt aaaggaatgg ctcgattatt 3232261 ataattggct cagccgtttg attgagtttt ttgagagcga agacattttt aaatatgtgc 3232321 cgaagccgta aaaagttccc aaattcaatt ctgggaactt ttttaagtcc aatccaaatg 3232381 gttgaatatc aaacttcaag aaaacaaaca aaataatgca taatttacat taatttatta 3232441 attatccatt ttttgttgat tattctgact agctattata taatcttttt gaaatgatta 3232501 tattagctta gaggaggtaa tctacatcaa aaaaaaggga attattactg taatgactat 3232561 atgtttccta ttattttctt cttattactt tagcaatatt tcacctcaga atccactgtt 3232621 caaaaaaaat tttttgcaac aattgtctcc ccaaggcttt ggcttttata gtaaaagccc 3232681 tacagaagaa aacatttcat ttcacacaaa agaaaattta aagttaccta atgcacttcc 3232741 caataatttt tttgggataa aaagagaagg aagagttcag gcaatagaat taggcaaaat 3232801 tgtagagaat atcgatccaa agaattggaa aacttgtgaa aacaacaact cctgcacaaa 3232861 tttagagaaa caaataaagc ctattaaggt tataaaaaat gaagattata tacatcttag 3232921 caaaggagaa tacctaatat atcgccaaaa accactctca tggtattgga tagactttaa 3232981 gcaaactacc tcttttgaaa gaaaggtgct aaaaataaaa atagtatgaa gatattaaat 3233041 agtttagaag gttatattga cacctataat ccatggaaaa atacatatgc actttttaga 3233101 agtttacttg gtttctcaac attactagta ctattattca atagtactga tattttattt 3233161 agttatagtg caaataatgt cacatgtgaa aatgtctata tccctaccgc tttttgtttt 3233221 gctaaagaat atagtatcaa ttttgagatt ataagatact taatgatttt tatattaacc 3233281 ttagtggtta tagggtggag acctagattt accggtttat ttcactggta tatttgctat 3233341 agtattcaaa cttcagcttt aactatcgat ggtggagagc aaattgcaac tgttctttct 3233401 tttcttatat tacctgttac attattagat tcaaggcgaa atcattggaa tataaagaaa 3233461 aacaataatg aatctttcac aaagaagaca gtattgtttt atataatgac aataattaaa 3233521 attcaagttt ttatcattta tttaaacgca gctttagagc gattgaaaaa taaagagtgg 3233581 gcagaaggaa cagcaattta ctatttcttt tctgatccgg tgtttggatt acctgaatat 3233641 caacttaact taatgaatcc actacttgaa agcaatttta ttgttgtcat cacttggtta 3233701 gtaactattt ttgagttgtt cttagcagca agcataattt caaatatcag aataaagaga 3233761 attgcccttg ttttgggaat attatttcat attgggataa tattcagcat tggtattgta 3233821 agttttggct tgatcatgat atcagcatta attatatatc tgcatcctgt acaacaaaat 3233881 atcactatga attggtgttc tcctttattt aaatatatat atgtaaaagg aaagagaaat 3233941 ttcaaaagaa taggaggtga atcagtcaag tttcttacaa aattgtttca tagctaacat 3234001 ttagataatg gagaaataac ttaatggagg tataataatt tgaaaagtaa attacttagg 3234061 ctattgattg tttccatggt aacgatattg gttttttcat tagtaggact ctctaaggag 3234121 tcaagtacat ctgctaaaga aaaccataca ttttctggag aagattactt tagaggactt 3234181 ttatttggac aaggggaagt tggtaaatta atttcaaacg atttggaccc taaactcgta 3234241 aaagaggcaa atagtacaga aggtaaaaag ttagtaaatg atgtagtcaa atttataaaa 3234301 aaagatcaac cacaatatat ggatgaattg aaacaatcga ttgacagcaa agaccctaaa 3234361 aaactcattg aaaatatgac caaagcagac caacttatcc aaaaatatgc taagaaaaat 3234421 gaaaacgtaa aatactcttc taataaagtt actccatctt gtgggcttta tgccgtctgt 3234481 gtagcagctg gatatttata tgttgtgggc gttaacgcag ttgcattaca aacggctgcc 3234541 gcagtaacaa ctgcagtgtg gaaatacgtt gccaaatatt cctcttcagc ttctaataat 3234601 tctgatttag aagcggctgc tgcaaaaacc ctaaaattga ttcatcaata atccattata 3234661 attgagtgtc ttgcggattg ctccgcaaga cactttttca acgtgaaccg tttaattttt 3234721 tgtaataatg atatgaagct agtgttgaaa taactaatgc tagaagaact agcacaatca 3234781 taataagaat tatatattct cctgtaaaaa atgaaagaac agctattata aaaccacaca 3234841 ctacaagtac tttagaggca aagcgatttc ccagtttcca aacagtctca tcttttaatg 3234901 tccaaggtgt cctcaatcca ataagatggt tttgttctgc tagctgcata gaatttccac 3234961 caataattaa aaagatacca acaccaagcc ctattattaa atcaatattc acttcgtatc 3235021 ctaaacttat caatagagtt gagagttgta aaatatataa aaggattaac atattattag 3235081 aagctaggaa aagcaatgct ttattttttt gtgtagactt aatagttaac atataaaaag 3235141 taagataata aataagcata acaacaggta taataaatat tgttaaaggt ttagatacaa 3235201 ttgcagccgg tttatttcct gaccattgta tcggtatttc ttctggaagg tattgatata 3235261 atataattga agtcaagaaa ctcaaacata caataattat ggaaattata tttttcttca 3235321 taaatcgtta tcccctttat ttataaagtt aagcatccaa tttattgagt cttgaagtac 3235381 tgttgtattt agagagtaat aaataaattg tcctttgcga tggtcactta tgacttccgc 3235441 ttgctttaaa atattcaagt ggtgcgaaat actcggtttg ctgatattaa aatgctcagc 3235501 aatatctccc gcagtcatat cccctccttt taacaaatcc aaaatttttc tccttgttgg 3235561 atctgatata gctttgaaaa cattattcat agcgttttct cctttacaaa aaaacattta 3235621 gacatttaga tatttgtata aatgtattat tttcattata acttgaattt ttttaaaaac 3235681 aaccctcaaa ttggttataa tatctgattt ttgtattttt tcaaatactc ggataatccc 3235741 aacgctggaa aatatgttta acagatacta acacatgttg tttatttaaa aaaaccacct 3235801 ctgttgtatt taaatagagg tggtttttct atcagctata ataaaatttc cttttttctt 3235861 tttaatcggg cttaatgctc gttcaagcca gcccatgacc aaatcggcaa tcaccgccat 3235921 cagagctgtg gggatcgctc ccgctaatat aatcgcggtt ccgtttgtgg cgtttgatcc 3235981 tctgacgatg atgtccccga gaccgccagc accgacaaat gtcccgatgg ccgtaatgcc 3236041 gatcgcaatg acaagcgcgg tgcgcaggcc ggccattatg acagaaagcg caagcggaag 3236101 ctcgaccatc cgcagcactt gaaattttgt catccccatt gcttttcccg attcaagata 3236161 ggcgtgctca atactgataa tccctgtata cgtatttctg ataatcggca gaagagaata 3236221 cagaaataat gacaatatca ccgtattagc gcccagcccc atgacaagca tcagcacggc 3236281 gagcatggcg agagccggga tggtctgaat gacattcgtg accgcaaaaa cccatccgct 3236341 taatcttctg tatctggcta tcaggatgcc gagcggaatt ccaacaatgg cggcaaataa 3236401 aacgccatac accgacatca gaaaatggcg gtaaaattcc tgcagcacgt aaccgccgtt 3236461 ttgcgaatag tatgtgccaa gctgctgtag tacttccata tgatccacct cttttcttag 3236521 tcaaaataat gatgtttctc taaaaattcc tttgctacga cagacggctc cttcagcttg 3236581 ccatccacct cataattaag ttcctgcatc gtttccgtgt cgatttgccc aatcagctta 3236641 ttgatcacac cttcaagttc cggatgctcc ttaagcacct tttccggaat caccggtgaa 3236701 cagtcatacg gcggaaagaa acgcttatcg tcttttaaga ttttcagatc atatgcttta 3236761 atccgtccat ccgttgaata agccaaaacc gcatccattt tcccgttttt gactgcgtca 3236821 tagactagcc cgatctgcat tggataagtt gtgccgaact caaagccata tgtgctgaca 3236881 aagcctttat acccgtcgcc ttttcgtttc agccaagcat tgtcgacgcc taatttatat 3236941 tgggaagcat ttttcttcag gtcagacacg gtgttaatat gctccttttc cgcaaacttt 3237001 tttgttacgg tgaaggcata tgtgttatca aagccgtagg aatcaaacca tttataagaa 3237061 aagcgctttt gaaactcgtt ctgcacaatg ttcagcgctt ttttcggatc tttctccgct 3237121 tccttgccga gggtgcttgt taaatctgtt ccggaatagc gcgtggctga aatatcaatg 3237181 tcaccgccca gcatcgcttg gtgctgaaca tagtttgagc cgaggttttt cactaaagca 3237241 gtattcaaat ctgtatcatg ttcaataagc tgcgcgatca tattcgctac aatttctgat 3237301 tctgtcatgc tctgcgcccc gattttgatc gtatcgtcag aagcgccgcc tagacccggc 3237361 agagagcagc cgcctagcag catgacaaag acgagagcaa acgcgccaag ccatttgatt 3237421 tttgtcattt tcaacagtgc caactcctta cgatacttcc ttcatccctt gcaagccttt 3237481 cggcgtcacc tttcgttctg tcacagccag aacataatca ataataattg ccagaattgt 3237541 gacaggcacg gcaccgccaa tgatatattc aggctggtat aggttcagtc cgataaaaat 3237601 atagtccccg aggccgcctc ccccgataaa cgacgcaagt gtcgcccagc caattaggta 3237661 gatcgttgat gtgcggatcc ccgccatgat gatgggaatc gccagcggga tttcaacgag 3237721 ccgaatctgc tcccagccgg tcatgccaat tcctttcccc gattccagga ggtttttatt 3237781 tacaccttta atgccggtat acgtattgcg caggatcggc agtaccgaat agaaaaataa 3237841 agcgacaatc gcaggcactt ttcctacgcc gagaagcgga ataaaaaagg ctaaaatcgc 3237901 cagactcggc agggtttgca caatgtttac gaaaccgata accgcacctg cgcctttttt 3237961 cattctggta agagcaacgc cgagcggcac tgcaacgata atgcccaata caacggctat 3238021 gagtgaaata tataaatgct ctcctgtttt atacagcagc tctccgccgt tcgtttgcaa 3238081 aaaagtcatc atttgattca tcttaaaaga gctcctcccc tggtcagatc gtcatgagct 3238141 ggttttcctc gtcgccccaa atggaatcgt atacgatatc aacgaggctc gctcttgtca 3238201 caatccctgc taaatggttc tgttcatcga ccaccggaac atacttgatc ccctgcttca 3238261 aaatttttcg gactgtatcg cgaagaagcg cccctttttg aacggtatat atatctgaac 3238321 ggtatacatc gccaacgatg ctcgcttttt tgcggttttg atcaatcatt tccacatcaa 3238381 catagccctt cagcacgttt tgccggtcca caacgagcag cgagtcaaca cgtttttctc 3238441 tcatcagctg aatcgcctga gaaagcgttt tgtccgcaga taccgtcacc ggcgttctgt 3238501 tcatcatttg ctctacccgc tcgatatccg gtcttgactg aatcaggcgc tctttcccga 3238561 taaattcttc aacaaactca tttgccgggt ttcgaagaat ctcatcaggt gtgccgactt 3238621 gaacgatttc tcccgctttt aatatcacaa tcctgtcagc aagcttaatc gcttcatcca 3238681 tatcgtgggt tacaaacaca atcgttttgt ttaaggttct ctgcagtttt ttgaattctt 3238741 cctgaaggga atcacgcgta atcggatcaa gcgctccgaa cggttcatcc attaaaatga 3238801 gagggggttc cgctgccagg gcgcgcagca cgccgattct ctgctgctgt ccgccgctga 3238861 gctcatgcgg ataacggtct aaatactctg ggcccatatc cacaagcttt aacagctcgc 3238921 gcgcccgttc tttccgtttt tcctcaggcc atttcagcag ctttggtacg agtgagatgt 3238981 tctgctggat ggtcatatgg gggaacaaac caatctgctg tatcacatag ccgatttttc 3239041 tcctcagctc aaccgggtcc tgttccataa tattttctcc gtcgataaag atccttccag 3239101 acgatggttc tatcagtctg ttgatcatct tcatcgtcgt cgtttttccg cagccgctcg 3239161 ggccgataaa acagataaat tcaccttttg caatatctaa atcaatgctg ttcacagctt 3239221 ttttgccgcc tttatatact tttgacactt gttccaattt cagcaatccg tgcacctccg 3239281 caggtttcct ttaaattttc tgaaaagtat aatccttatt atagtttgaa ctttgtaaaa 3239341 taaaaagttt acaatgtgtt gaaattatat gttatttata gattatttat tgttatgacc 3239401 gagacggaaa gggtgttctt acaattactc cggatacctc ccacttcctc tgcattcagc 3239461 tattttcaac accaggaaga aatatgatat attgacacca tcaattgcca tttgaaggga 3239521 tgatcagctg tgaaaaaaac cgctctcgac atcattgaac atgctgaaga gcatctcatt 3239581 gagaagattg ccgaaaatat gcatacgttt ggaatgcctt caactgtcgg acgtgtgctc 3239641 ggaattattt atatgaatcg aaaaccaatg accttaagcg agctctctga ggcaacgggc 3239701 atgagcaaaa cacggatgag ccaggttgtc cgggaaatga tcgatgccaa tatcgccgaa 3239761 aaggtgtttg aaaaaggcgt acgaaaagac ctttatgacg tcgagcagga ttattatcaa 3239821 accttcattt ctttatttgc ggcgaattgg acaaaggtcg tgagcaaaaa caaagtgctg 3239881 tataaaaaat taaaccggga gctgagtgat cttttacaaa gggacgggct taccccggaa 3239941 gcggaagaga aagtcaatca gctgctgaat gaattaaaag aatggcttca ttactatgat 3240001 tggctgagca ggttgattga attttttgag agtgaggaag tctttcggta tgtgccgaaa 3240061 acaaaagaat gcagctctct aaaataagag agctgctttt tgcatcatga agttaagacc 3240121 ggaaacatgc ctttcagccc ggcaccaatc atcccgaccg caaccacggc taagattaat 3240181 cccatcagtc tggtaatcac attcatctcg gtttttccga gtttgctgct gataaaagca 3240241 gaatagtgga aaaagagaaa ggtcagggca ataacggcgg ctatgccgat catgacagcc 3240301 gcataatgac caatgccgct atgtccggcg gaaaggctca tcactgttgc aatcgttccg 3240361 ggcccagcaa tgatcggaat ggataaaggt gtgactgata tatccgcttt ttccttgctt 3240421 tccttatgtt catcatggtg aagagattgc acgtgcgatt ctttcgcatt caatagatta 3240481 taggcaatgc cgaaaatgaa tatgccgccc gccactcgga gcgcgtgaat gttgatatca 3240541 aacagtttaa agataagatg accgaaaacc aaaaaagctg cgagaataaa aaaggataaa 3240601 atagctgcct tccgggcaat cgcttttctt tccgctgcag tatagccttc tgtcagcgtc 3240661 agaaatatcg gtacgtttcc gatcggattc gatactgcga ataaagaaat gaagacgtga 3240721 acgataaatg agaacatcat atacctcctt gttgatagtc tctgcacagg aaatagaatg 3240781 attctccacc cttttacccg gaggcgattt cccggtaaac ctttatagcc tgtcagaaac 3240841 gcgccatgct acaatgaagt gacaaattga ataggaagga cgtatacaga tgttcaaaaa 3240901 aattgcggca gatgccttgg gcttatctga tatcggaaaa attatcgaac ctcaggacta 3240961 tgacaaaaca gacgcagatg actatgtcat gcatgaagat aatgagaaaa tttatttctt 3241021 gattaaaaca aaagcagacg agtattgctt tacgaacctg gccctgatcc atgtggacgg 3241081 cgaacgcgcc acttcctcaa aacgaacgtt gaaacgctat ccttattcgc aatataaaat 3241141 ctctgacgtt tttcttgaaa ctgccggaaa agtggatttg gatgttgaaa ttaagttcaa 3241201 gctgggcggt gaacaattcg acattgatgt ccacaaagac cagattgaaa agttaaaaga 3241261 cctttataaa gcactgcttc gcatcgctga aacaacctat gaaaatgaca ttttaatcaa 3241321 tcaagcggag caaagcttag ataaagcagt gacgattctt caccataccc gccctgagca 3241381 cgtcaatatt gaaacgcaat acaaagagct gaccgaattc ggattcactt ggctgacatc 3241441 cgttcgctcg cagtatcata ttaaggattt tggggatgta tttgagaaat atattaataa 3241501 ctagataaaa aaagacacag ctgctatcgt gctcgtgtct ttttttgtat gaatattgat 3241561 tactttacaa cttttttctt ttataataaa actattagtc tattttccct atattacaga 3241621 taaaggagtt attttatgta ttgtcctcaa tgcggccatc aaacagatgg cggaaatttt 3241681 tgtgagaaat gcggatcacc gctccccggt caatcaggcc accagcatgc agctcaaact 3241741 ggagccgctg caaagcaagc agcaaaacag ttcggttcat ttgtcttatc cgtcctgaaa 3241801 cgcccttatc aggaatgtaa agcaacaggc ggagaacagc tgatcagcgc aatcattacg 3241861 atggttcttt tcagtttgct gacccctttg atgttttata ttcttttttc agacggtccc 3241921 ggaagcgtaa gctttacagc aatcttctta gagccaacca tttattttat tttatttcta 3241981 tttggcctgc atgcatgcat ctttttcgcc ctgaaaatcg cgggaaacca agtgtctttc 3242041 aaggattcat tctcaagatt cggagcattt cttattcctt ttacggctat tttgattctt 3242101 gcccttttct tctttttatt acatacagac atttgcttta ccatattagc cgttggttta 3242161 atcggtgcat tcttcgccat tcctcctgcg atgctgagca gttaccagca ttcatataaa 3242221 gggaaggttg atttcattta ctcaacgatt gtgatttatc tgatcatctg cgttacattt 3242281 cagcttatta tcgaacacta tgtcaaagaa attttccgtt atatgctctt ttaaaaacaa 3242341 ccccatcacc tgctggtgat ggggttgttt tattgaatag acgttaagta aattcttccg 3242401 ttcttcacta cgccggtgta ggtccagtta tatgttctga gctttggact gccgcctgat 3242461 tttgtgatat agaattcttc atacgtctta atcgtgatag ccgacccatt ttggctccag 3242521 cttttcactt catagttatt aaagtcttct gttgtcccct ctttatttaa tttcgacacg 3242581 agatgctgct ggtcggaata aagggaactg cctttttcaa ggctgtcttc catcagtgag 3242641 aaattatttt gattcacggc atctgcctga ctttgcagat aactgcccat aaataatgtc 3242701 acttgttcat ctgtaacatc gccgcttgca gagctttcac tgcctttgtt tttcgagcca 3242761 gcccaggcgg aagtgtatgt ctctggttta tcatttttga ttttctttat atttgtgcct 3242821 gcagattcga atgttgattc tgcatcttcg aaaatccact ttttctgttt tttatcatat 3242881 gaaagaagat attcataact cggactgtcg tcagtcattt cagactttgt atagtcgtta 3242941 tacgaagaag actggtgaag ttcttttcct gttaccgata cctgccacgt tccgtcgttt 3243001 ttctgagaga gggcaaatgt gtccaggtca aaatcagttt ccaagtatct atcttttaag 3243061 tatgaatccg cgcttttcat agaatcgacg gtgtccttcg tctccgcctt ccaattggca 3243121 cttgcctctg tcatctgggc tgtattccca tcagatagag ctttggagta ttgttttgtt 3243181 gttttgacaa ttgtgttcat aatctgttcc tgtgtatctt gatcaggaat taacgttaac 3243241 tccatttctt tatcatcgat cggaacgccg gcagtttttg tttttcccca cggaaattct 3243301 gcctcgactg aagctgtcat tgatccatct gtcagcagcg gaccatatgt tacggatttg 3243361 aacggatctt tatgaattga tttaccgtta atcagcaaat ctcccttccc gctcttgatg 3243421 tcattcgcta agctgaatgt cacatcgtct gcttccaatg agagatcaac acgaaagctg 3243481 ctatcgccaa tcgcctgaat gtcttccttt ttcacaaggt caacgacatc gtttttcagt 3243541 ttggctgaga ctgtatattc gccgggaatg tacggaccaa gggtttgtgc ttgatctgct 3243601 ttctttacag atccggcttc ctctttattg acatatagat cggtattttt ataattgctg 3243661 ctcacttcaa aataaacagg tgctaccttt aagtcataat ggtcaaatac cagcaggctt 3243721 ttcccgtctt tttccgcata tacgatatcc ttctgggctg tttcatcacg cagcgatgca 3243781 aaaagttcat cttttttgtc tggatgatcc ttcaaatatg taagaaacgg ttttacatta 3243841 tttttagtga gtttaagatt gtcatttacc ggtgtaagca gagtcgcgat ttggtcctga 3243901 tccccatcat ttacggcctg ttcaaacttg tctactaacc tatcctttga agtaaaatac 3243961 gctccggttt tatatgcggc gaataatata acgcacgccg cggcaatgct gctccataaa 3244021 atgatggttt tcttagggat cggttttcgc ggagcctgcc tcgtttctgc agtgctagct 3244081 gtttcttgat ttgcctgttt gctgccccct ccgatcgggg tgccgcattg tttacaaaac 3244141 ttggctcctt cattattctg ggagccgcaa ttcttacaaa ataacatgac tttcctccta 3244201 ttctactaat ttgataacat ttactgcttt tcatatttta taataaaaca gaatgaaatt 3244261 gggaacgaat gaaaaaatta aatgtctatc agactaaaaa ggtggaatga atatgcaaaa 3244321 gctcaggatt gaattaggag aagaaacaaa tgacgaatta tatgatctat tgctgctcgc 3244381 cgatccatcg aaagacattg tagatgaata tcttgagagg ggagaatgtt acacagcttg 3244441 ggccggtgat gagcttgcag gggtttatgt attgctaaaa acaaggccgc aaacagttga 3244501 aattgtaaat attgcggtaa aagaatctct tcagaagaaa ggctttggca aacagcttgt 3244561 acttgacgcc atcgaaaaag cgaagaagct gggggcggac acgattgaaa tcggaacggg 3244621 gaattcgagc attcatcagc tttccctcta tcaaaaatgc ggattccgca ttcaggcgat 3244681 cgaccacgat ttctttctca gacattatga tgaggacatt tttgaaaacg ggattcaatg 3244741 ccgcgatatg gtaaggcttt atttggatct ctgaaagcat aaaaaagccg ccgagagaaa 3244801 atcccggcgg tctttttatt acttgtttaa gttgtagaaa gagttgatac cgtggtattg 3244861 agcagtttca gccaactgat cttcgatgcg aagaagctgg ttgtatttcg caacacggtc 3244921 cgtacgagac ggagcacctg ttttgatttg tcctgcgttt gttgccacag cgatgtcagc 3244981 gattgtgctg tcttcagttt caccagaacg gtgagagata acagctgtgt agcctgcgcg 3245041 tttcgccatt tcgatcgcat cgaatgtttc agtcaatgta ccgatttggt ttactttgat 3245101 caggatagag ttgcctacgc cgtttttaat accttcagaa agttttttcg tgtttgtaac 3245161 gaagaggtcg tcaccaacaa gctgaacttt tttgccaaga cgctcagtaa gaagcttgtg 3245221 gccttcccag tcgttttcgt caagtccgtc ttcgatcgag atgattgggt atttagaaac 3245281 aagctcttca taccagtcaa ccatttcagc agatgttttc acaacgcctt cgccagacag 3245341 atggtatttg ccgtcttctt tgttgtagaa ctcagaagat gcagcatcca tagcaagttt 3245401 aacttcttcg ccaggtttga agccggcttt ttcgattgct tcaacgattg tttgaagcgc 3245461 ttcttcgtta gaaccaaggt ttggagcgaa tccgccttcg tcacctacag cagtgtttaa 3245521 gccttttgcg cttaatactg atttcaggct gtggaagatt tgagcgccca tgcgaagtgc 3245581 ttcacggaag ttaggagcac ctacaggcat gatcatgaat tcttgaatat ccacgttgtt 3245641 atcagcatgc tctccgccgt ttacgatgtt catcatcggt acaggaagcg tttttgagtt 3245701 gaatcctcca aggtattggt aaagaggaat ctgtaagaaa tcagcagcag cacgcgcaca 3245761 agccatagat acgccaagga ttgcgttcgc accaagtttg cctttgtttt cagtaccgtc 3245821 aagctcgatt aaaagctgat cgattgcgtt ttgttcagtt acatcaaagc caagaagctc 3245881 tggagcaatg atttcgttta cgttgttaac agctgttaac acgccttttc caaggtaacg 3245941 gtctttgtcg ccgtcacgaa gctcaaccgc ttcgtattca cctgtagaag ctccgcttgg 3246001 cactaatgcg cggccgaaag ctcctgtttc tgtatatact tcaacttcaa ctgttgggtt 3246061 gccgcgggag tctaatactt cgcgtgcata aacatcaaca atgtatggca tgagttttgt 3246121 ctctcctttt gattttcaaa ttatttttga attaaagatg ttcctgtcat ttctttcggt 3246181 ttttcaacac caagaaggtc taataacgtt ggtgcaaggt cgcctaggat tccgccttca 3246241 cgcagcgtaa tgccttcttt cgttacaatc acagggactg ggtttgttgt atgcgcagtg 3246301 tgcggttcgc ctgattctgt aatcagaatg tcagcattac cgtgatcagc ggtaatgata 3246361 gcgtgtccgc ctttagcaag gatcgcgtca acgacttcgc ccaagcattc gtccactgct 3246421 tcaattgctt taattgttgg ttcaaccatt ccggagtggc cgaccatatc agggtttgcg 3246481 aagttaagaa tgatcgcgtc atgcttgtca gcttcaattt ctttgacaag cgcgtctttc 3246541 acttcatacg cactcatctc aggcttcaag tcatacgttg caactttagg cgagttgatg 3246601 agaatacgct cttcacccgg gaattcagct tcacggccgc cgctcataaa gaacgtgacg 3246661 tgcggatact tttcagtttc tgcaattcga agctgtttta acccgtgctg agataatact 3246721 tctccgactg tgttatcaag atttatcggt ttaaacgcta catagccgtc aactgtttca 3246781 ctgaagtgag tcaggcagac gaaatacagg ttctttggat aattctcgcc gcggtcgaag 3246841 tcacggaagt ctttgtttgt gaacgtgttg gaaatctgga tggcgcggtc cggtctgaaa 3246901 ttatagaaaa tcacagaatc gccgtcttgg attttcgcaa caggctcacc gttttctttt 3246961 gtgatgacag atggaatcac gaattcatcg tagataccat ttgcatatga atcatcaaca 3247021 acatccaggg cgctgcggta agatgggcct tcgccgtacg ccattgcgcg gtacgctttt 3247081 tctacacggt cccagcgttt gtcgcggtcc atagagtagt aacgtccgga aatgctggcg 3247141 atttcaccta caccgatttc cttgatttga tcgttcaact ggttgatgta cgttttcgct 3247201 gtctgcggac ctacatcacg gccgtcaagg aagccatgga tataaacctt tgtcagccct 3247261 tcttttttcg caagctttaa cagtgcgaat aaatgattga tatggctgtg cacgcctccg 3247321 tcagataaaa gaccgaacag gtgcaaggct ttgttgtttt ctttcgcgtt gctgatcgcg 3247381 tcaaggaatg tttgattgcg ttcgaactct ccttcacgaa tggcaacatt tacgcgtgtt 3247441 aagctttggt acacaatacg tcccgcaccg atatttaagt gacctacttc ggagttcccc 3247501 atttgccctt caggaagacc tacagcctcg cctgaagcag tcaaagtttg atgaggatac 3247561 tggttccaat agcggtcaaa attcggtttt ttcgctaaag cgactgcgtt ccctactgtt 3247621 tcgttacgta atccgaaccc atcaagaatg atgagtgcag ctggtttttt actcatattg 3247681 accttcctcc aataattgaa cgaatgactg tggctcaagg ctcgcgccgc cgaccaaagc 3247741 accgtcaata tcggactctg ccatatattc tttaatgttt gcaggcttta cgcttccgcc 3247801 atattggatg cgaagcttgt ctgcagcttc ttggctgaag ctttcagcga cggttttacg 3247861 gatatgcgca cacacgtcat tcgcatcttt cgctgtagaa gatttgcctg ttccgattgc 3247921 ccagattggc tcatacgcaa taacagaagc agcaacttgt tcttcagaaa gaccagcaag 3247981 gccttttttc acttggtcag caacaagatc atttgttttg ccggcttcac gctcttcaag 3248041 cgtttcacct acacagatga tcggcacaat gccgtgtttg aaagctgcgt gtgctttttt 3248101 gttaactgtt tcatcagttt cagcgaacat ttcacggcgc tcagagtggc cgatgacgca 3248161 gtagtcaacg ccaaggtctt tcagagcaac cgggctgatt tcgcctgtga acgcgccgct 3248221 ttcttcgaag tgcatgtttt gagcgccgac ttttaggtca gtgcctttca cagcagaagc 3248281 aagcttttct aagaaaagcg ctggcgcgca aacaacagct tcagctttgt ctgctgctgg 3248341 aatggaagat ttcacttctt caacgaagct gacagcttcg ccgagtgttt tgttcatttt 3248401 ccagttaccg gcgataattg gttttctcat ctgttccact tccttatagc agttttgaga 3248461 ttatttatcg ttcagtgcag ctacccctgg aagctctttg ccttccataa actcaaggga 3248521 tgcgccgccg cctgttgaga tgtggctcat tttgtcagca aggccgaatt tttcaaccgc 3248581 tgccgcagag tctcctccgc cgatgacaga gtatgtatct ttcgcctctg ccaatgcttc 3248641 cgcaaccgct tttgttcctt gagcgaacaa gtcgatttcg aatacgccca ttggtccgtt 3248701 ccacacgaca agtttgctgt ttttgatgac gtcagcatac gtttcgcgtg ttttcgtacc 3248761 aatgtcgatt gcttctaaat cactagggat ttcagagatc ggcacaattt tcacgtttgc 3248821 atcgttagag aaatcatctg caacgagtac atcttcaggc atgtagaagt taacgccttt 3248881 ttctttagcg cggtccataa atgatttcgc aagctcgatt ttatcctctt caagaagaga 3248941 tttcccgact tcatagccaa gcgcttttac gaaagtataa gcaagacctc cgccgatgat 3249001 caggttgtct actttatcaa gaagactttc gattacaccg attttgtctt ttactttcgc 3249061 tccgccgatg atcgctgtga acgggcggtc aggattggaa accgcttttc caagtacatc 3249121 aagctctttt tccattaaga aacctgcaac tgctggcaga tgctcggcaa ttccagctgt 3249181 agatgcgtga gcacggtggg cagcaccgaa tgcgtcattt acatatacat ctgcaagctc 3249241 agcaaatgct tttgcaagct caggatcatt tttctcttca ccaggataga aacgtacgtt 3249301 ttccaataca agaacgtctc cgtccttcat ctcagaaatt tgtgctttta cagcatcgcc 3249361 gtatgcttca tccgcttttt tcacttcttt gccaagcagt tcgccgagac gtgcagcgac 3249421 aggagttaaa cgaagctcct caaccacttc gcctttcggg cggcctaagt ggctcgcaag 3249481 aaggactttt gcgccttggt ctgcaaggtg tttgattgtt ggaagcgcag cacggatacg 3249541 tgtatcgtct gttacttccc cgtctttcat tggaacgtta aagtcaacgc ggcagaatac 3249601 aactttgcct tttacgtcga tgtctttgag agttttttta ttcatgccta ggagatcctc 3249661 cttcaaaatg gtttgcatac agcacgaaaa acgtgaaacc gtctgttcaa gcgataactc 3249721 cgctagggca gatcgcagtc tttttcggca cagggcagtt cgtctaaaag ccagggcagc 3249781 ggccttaggc gaaagcgccg gcaaagctgc ttaaaacgcg gtcgtttctc tatcacagag 3249841 cgttttctga aagccggtct tcatggaaaa agggaaaggg agtccgtccc cttcccttgt 3249901 ccgctttcat tatagcgctt ctattcgaaa gaaccaagtc aggtcctttt tcagctataa 3249961 attaaagacc tttttttgcg atgtaagctg caaggtcaac aacgcggtta gagtagccgc 3250021 tttcgttatc gtaccaagag attactttta ccatgctgcc ttccataacc attgtagaaa 3250081 gagcatcgat tgtagaagag tttttgtttc cgttgtagtc gccagaaact aatggctctt 3250141 cgctgtagcc aaggattcct ttaaggtcgc cttcagccgc ttctttaaga gctgcgttta 3250201 cttcttcagc tgttacttct tggttcagtt cagcaaccaa gtcaactaga gaaacgtttg 3250261 gagttggaac acgcattgct ccaccgttca gtttgccttt tagttcagga agaactagag 3250321 aaactgcttt agcagcacca gttgatgttg ggatgatgtt ttcagctgct gcacgcgcac 3250381 gacggtagtc tttgtgcgga agatcaagga tttgctgatc gtttgtgtaa gagtgaacag 3250441 ttgtcatcat accgcgtttg atgccgaatt tatcgttaag tacttttgca aacggcgcaa 3250501 ggcagtttgt tgtgcaagat gcgttagaga taacatcgtg gttagccgca tcgtatttat 3250561 cttcgttaac acccataacg attgtgatat cttcttcgtt agcaggagca gagatgatta 3250621 cttttttcgc gccagcttct aagtgtttcg cagcgtctgc gcgttttgtg aagaaaccag 3250681 tagattcaac tacgatttca acgccttgtt tgccccagct aagtttagca ggatcgcgtt 3250741 ctgcagaaac ttcaattgtt ttgccgttaa caacaaggtt gttaccgtca actgaaactt 3250801 cagcgtctaa ttttccgtgt acagaatcat attgtaaaag gtgagccagc atgttagcat 3250861 ctgttaaatc gttaaccgct actacctcaa cttcaggatt gtttaatgct gcgcggaata 3250921 cgttacgtcc aatacgacca aaaccgttaa taccgacttt tactgccatg attgtttcct 3250981 cctttaaata agtgagagat atttatattg agggattatt catcccttaa taacttcttt 3251041 gcggctcctt cgtctgtgac gagaaccgtg ttgcgtggct ttttaaagta agcctcgatc 3251101 gcttcggctt ttgatgatcc gcccgctacc gcaataatat cggggatggc gtctatgtca 3251161 tccagctgca ttccgacaga atgcactttg tgaaccactt cgccgtccgc gttaaaatag 3251221 tagccgaacg cttccgtcac cgcgtcgtta tcatctattt tctttaaatc ttctaaaggc 3251281 gtgtttctgc gctgagccat agttttagct tcgccgattc cgtgaaccag catactcgct 3251341 gatttaatgg tgttcagcac ctctttgaca gaaggctctt caataataga tgaataggcg 3251401 ccttgtgaca gctgtcccgg aacaaacaaa agccggtaag tgcctgaagc cttctccgcc 3251461 atatgcgcgc atatggtgtt cgcctggttt ttcacgtctt cgcctaaacc gcctcttgca 3251521 ggcacaaaca aaagctcgcg gtttttagaa tccggcgtca tcatttcggc gacagcttca 3251581 attgtcgtac cgccagttac agcgacgata tttttgcctg aaaatctttt tttcatacat 3251641 gcgacagccg ctcttcccat ttcttttttg acccatgggg attgatcgct gtctccggat 3251701 acgataatgg catcctttag atttaaacgt tcttttaatg tcttttccaa aagagtcaaa 3251761 cctaaaacat ctttcatcgt atcttccaaa acagaaagca gttcatagcc ctcttctgtc 3251821 aatgtcatgc cgtttgtctt aatatcgacc aggttctgtt cctttaaaaa ctgaacctcg 3251881 cccctcagca cacgctcgct gattccgaga ctggcagaca ggcttcttcg cccgatgggt 3251941 tctgtcagcc tgatatactg caagatttca aacctctttt gcataacgag cagaagatca 3252001 ggcaataatt ttttttgagc ttgtattaac tggttcatga ctcaaacgtt ccttcctttt 3252061 ttgctggaca ttatatgtcc cgctatgaca aaaaacgtcc cgtcatagcc aaaaaaaatc 3252121 atttctgctt tctttaatta ttttaacagg gtggaattgt ttattcaact gttaagagcc 3252181 aattcatcga caatattcgc agagttttca tgccgcgtcg ttttatccag caatatttta 3252241 tcctatatat ctttatctta tacagaaagc gccaaatggt gcatcccaat ataaacagcc 3252301 cttcccgtag aaagggctgt ttcattaaag cgttttcatt ttatccaaag cttttcaatt 3252361 tcctcgagcg atttgttctt cgtttctgga cagatcgtaa cgacaaacag gaaacaaagg 3252421 atgttaatca ccgcaaagat ccaaaatgta taggcgagcc cgaaagaatc gatcatcatt 3252481 ggcacaaact gtccgatcgc ccagtttgct ccccataaaa agatggtcgc aatgcccgcg 3252541 gcccgcgcac gcagatggtt cgggaagatt tcagaaatca taatccatgt gatcggtccg 3252601 accgagacac agaaagcagc gacaaaacct aatataagga cgatcatcat gatcccgctt 3252661 gttaactcaa aataaaacga cgtcccgatt aaaatcataa aaatagccat aaaagcagaa 3252721 ccgatggaca tcagtttttt tcgtccgact ttatcaatca gcaacaccgc aataacggta 3252781 aaaataactt ctacaacccc gacgatacaa gtcgtcacaa atccggcgtt ttgcccgaat 3252841 cccatcattt taaagatttc cggcccgtag taagtaatcg cgttcatgcc gatgacttgg 3252901 ttaaacagcg ccagcaggat tccaatgaca agcgcctttc tgagacccgg cttaaacagc 3252961 tgggagagcg accccatttg ttctattttt aaagagttct caatgttctt taattcttct 3253021 tttgcaacag tttctccatt aatacgtgtc aggatcttta aagcttcatt tgttttgccc 3253081 gctttcgcca gccatctcgg actttccggg acgacgagca ggacaaggaa aaaaatgacg 3253141 gatggcacca ttccataagc aagcatccat ctccagccgg tgtgcacgcc ccattcgtat 3253201 gttccggacc gctgcacagc tagattaata aagtatgttg cggaaatacc cagtatcgta 3253261 aagagctgat ataacgaaga taaacttccg cgtatagcgg gcggtgccgc ttctgtaata 3253321 tacgtaacag agagcgatga gcccatcccg attcccagcc ccccgataat ccttgcaatg 3253381 attaaggtgg acacgtcttg agaaagcgct gaaacgattg ctgatatcgc aaataacaaa 3253441 gcggctgtca ttaaaatttt tctccggccg aatctgtcac ttaaaaatcc ggatatcccg 3253501 acgcccacaa ctcctccaat cataatgctt gaaatgacaa gtccctccat aaacggactc 3253561 aggctgtata aatctttcag aaaaccgatg gcgccagaaa tcactgccgt gtcatagcca 3253621 tacaataagc cgccaagccc cgccgcacat gagatcaaaa tgacaaatcc cattgaatgg 3253681 cttcttgtta caggaacatt tggttctaat tgagttggag tattcttcat ttccctgccc 3253741 tcccgaatgt tgagtaaagc gttttcattt aaaccttcaa ttgtacgtac ttatattaaa 3253801 atttaacgaa aattacattt aattagtacg tacaaatata gaataatctt gtttgcattt 3253861 tctgtcaatg ttttcttaca aagaacgctg tgatatactg aaatttgtcc gtatacattt 3253921 tggaggaatg gatatgttac caaaatacgc gcaagtaaaa gaagaaatca gttcttggat 3253981 taatcaaggc aaaatactgc ccgatcaaaa aatccctacc gaaaacgaat taatgcagca 3254041 attcggcgtc agccggcata ccatccgcaa agcgatcgga gacctcgtat cacaaggtct 3254101 gctgtacagc gtgcaaggcg gaggcacctt tgtcgcttca cgctctgcta agtcagcgct 3254161 gcattccaat aaaacgatcg gtgttttgac aacttacata tcagactata ttttcccgag 3254221 catcatcaga ggaatcgagt cctatttaag cgagcagggg tattctatgc ttttgacaag 3254281 cacaaacaac aacccggaca atgaaagaag aggcttagaa aacctgctgt cccagcatat 3254341 tgacggactc atcgtagaac cgacaaaaag cgcccttcaa accccaaaca tcggctatta 3254401 tctgaacttg gagaaaaacg gcattccttt tgcgatgatt aacgcgtcat atgccgagct 3254461 tgccgcgcca agttttacct tggatgatgt gaaaggcggg atgatggcgg cggagcattt 3254521 gctttctctc ggccacacgc atatgatggg tatttttaaa gctgatgaca cacaaggcgt 3254581 gaaacggatg aacggattta tacaggcgca ccgggagcgt gagttgtttc cttctccgga 3254641 tatgatcgtg acatttacaa cggaagaaaa agaatcaaaa cttctggaga aagtaaaagc 3254701 cacactggag aaaaacagca agcacatgcc gacagccatt ctttgttata acgatgaaat 3254761 tgcgctgaag gtgattgata tgctgaggga gatggatctt aaagtgccgg aggatatgtc 3254821 tattgtcggg tacgatgatt cacatttcgc ccaaatctca gaagtgaaac taacctctgt 3254881 caaacatccg aaatcagtgc ttggaaaagc agccgccaaa tatgtcattg actgcttaga 3254941 gcataaaaag ccgaagcaag aggatgtcat atttgagcct gagttgatca ttcgccagtc 3255001 cgcacgaaaa ctgaatgaat aaaaaaagca atgtatgggt ctccccgcta cattgctttt 3255061 tttatagctg ttatctgttt ttccaaacgt cagcgatgat ttcaaacgaa cgcattctgt 3255121 ctgcgtgttc aaaggtttct gagttaacca taatttcgtc agcctgtgtc gttttgacga 3255181 aatcttcaag cttcgccttc acttcttccg gacctccgac aatcgtggag ctcagctgct 3255241 cattgaccat cgctttttca tacgggctcc agatttggtc catatcctca acaggcggtt 3255301 taagctggtt aggcgtaccg cggacaagat caagaaacct ttgataatgg gaagtcgcaa 3255361 ggtgctgcgc tttctcgttt gtatctgccg cgataatggt gacaccgacc atcgcatacg 3255421 gttcgtcgag cacgtctgac ggcgtgaagg aattgcggta cagctccaaa gcgggaaccg 3255481 tattcgccgg tgagaaatgg gccgcgaacg caaacggaag accaagttcg ccagccagac 3255541 gggcgctgaa gccgcttgag cccagcagcc aaatcggcac atctatgccc tctccgggaa 3255601 tggcgcgaac ttgattgcgc acatttcctg acggtttaaa ataattgcgc agttcctcta 3255661 attgttctgg aaaatcctcc ccgctgttga tgtttctgcg gagcgctctg gctgtcaatt 3255721 ggtctgttcc cggcgcacgt ccaagcccca gatcaatccg cccgggatac agtgtttcca 3255781 gtgtgccgaa ttgttcagca atgactaatg aagagtggtt ggggagcata atgccgccgg 3255841 aaccgacgcg gattttcttc gtgcctccgg caatatggcc aatcaaaact gcggtggcag 3255901 agcttgcaac accttctata ttatgatgtt cagcaagcca gtaacggtga tagccccatt 3255961 cctctgcccg gcgcgccaag tccatgctgt ttcggaatga ttctgcaatc gttcctccct 3256021 gaacaaccgg agataaattc aagacagaaa gcaaggtatc tttgcgttgg ttgttagaca 3256081 tattgttctc ctttgcaaat gtgttatcag taaacagccc aaagctgtca ggtcatgatt 3256141 gaaagaactt ctatcacacc ataacacaac tgcattcagg aataaaagaa tttgattcga 3256201 tgaaattcga acaatataaa acgaacggtt tggaacatta ttctgctcca aacaactcct 3256261 tagccatctc aataaagagc ttagccgcca gagaagcctc ctttagcgac ggaacagcaa 3256321 gctgcacatc acggtatacc tgcgggtcca attccctggt caccacatgc tctggcagcg 3256381 gcatccccga catggacatt tctgataaaa tggccaggcc caggccttct ctgatcatac 3256441 tgatcgaggt gttgatgtta tagaccgtga aagctgggtg cagcgtagca cccgcctgcc 3256501 tgaacatatc gataaatggt gattcatagc cgccgtcaca gacgatcatc ggttcatggt 3256561 caagatcttt cagcgtaatg gctgaatgac tggcaagcgg gtgatcgtcc ctgagcacga 3256621 cagccatttt gtcttttttc aaatgaatgt actccatctc ctctgttgga tacagaagaa 3256681 tcccaacatc tatcatccgc gtatgaagcc actccttgac ttcatttaca gttccctcgt 3256741 gcagcacgag ctcaagtttc ggatattttt gtttaaattc actgatcagc ttcggcataa 3256801 aataagccga ggcagttgag aatgtgccga tatggatcgt tcccagttca agcccttttt 3256861 ccgctgctgc tacctgctca actttttcaa tgccttttaa gacttctctg atgtgtacta 3256921 agatctgttt tcccgtatcc gtcagcatca ggccattgcg gcggtcacga atgatcagct 3256981 ttacatcaag ctcagcttcg atcgcagaaa tcgcatggct gacagccggc tgtgtcatgt 3257041 tcagcgcctg acccgctttt gtaaagcttc ccgtttcagc tattttcaca aaaaccttta 3257101 attgagtaat ggtcataaca atttacttat gctccttata aaaaagattc attttattta 3257161 tcttatgttc taccgtatca tatgatggaa aagttctaca aggagtgaat gaacaatgaa 3257221 gcagctccca aaaacgcgga cagctctcct gctcgcattt ctcgtcatca tgtggggcgt 3257281 caattggccg ctgtccaaag ccgcgctcgc ctattctccg ccattattgt tcgcgggcat 3257341 ccgaacgctg atcggcgggc ttttattagt catagtcgca ctgccgcgta ttcataaatt 3257401 acgcttaaaa gaaacgtggc cgatttatct tgtttctgct cttttaaata ttacattatt 3257461 ctacggcctg caaacgatcg ggctgaatta tcttccggcc ggcctgtttt ctgcaatcgt 3257521 cttcttccag cctgttctga tgggtgtatt ttcttggctg tggctcggcg aatccatgtt 3257581 tgtaatgaaa gtgattggcc tcatcctcgg ttttgcggga gtagccgtca ttagtgctgc 3257641 gggctttggc gggcatattt ctgtcattgg ggttctgctg gctctcggct ccgcagtcag 3257701 ctgggcgctc gggacagtat atatgaaaaa aacaggcagc cgcgtcgatt ccatctggat 3257761 ggtcgctctg cagctgacga tcggaagcgt gtttctgctt atctccggct tttggacaga 3257821 aagcttttcg gcgatccaat ggacagctcc gtttattacg agcctgctgt tcatctccgt 3257881 attcgttatc gcactcggct ggcttgtctt ttttacgctt gtcggttcag gagaagcaag 3257941 caaggtcgca tcttatactt ttttgattcc gctcatatca atcgtggcca gctccatttt 3258001 cctgcatgaa ccgctcaccc ttagcctctt ggcagggctg ctgctgattg tcacgagcat 3258061 ctgtctcgtg aatacaaaat caaaagcgca gaaagctgcg gcgattggta taaacgagaa 3258121 agctgcacaa taataaaaac cctcttgccg gatgcggcaa gagggtttct tatttactga 3258181 tgcttgcgtc ctttgaccaa atatgcaact gtaatcaaaa ggtagatcgc cgcagtaatg 3258241 ccggtaatga caattgatgt tgtcatgatg accccgatca gaatggcgag taatgccaca 3258301 atcgcaaacc atgtcgtgta cgggaaccat tttacataat aggccggtgt ttccgtttgc 3258361 tgttttctcg attttaaatg agcgaatccg atgatcagcc aaatgaataa aacggtatat 3258421 cccaatgatc ccattaaata attaaatgtt tggcttcctg cgaacagaga aatcaatacg 3258481 ccaatataga gagaagaagt gcacatcaga atcgcaaaca tcggtacgtt tttcgatgaa 3258541 agcttcgaga agacctttgg aagccttccg tcacttgcct gtgtatacaa aatgcgtgat 3258601 gatccgtata aacctgaatt catagaagaa atgatcgcca gcaggatgac tgcattcatg 3258661 atatgatccg cgcccggaat gcctaccatt ttaaagacca tcacgaaagg actttccgga 3258721 acggaattga cttggttcca tggaatcagg ctgacgatga tgaaaaacgg cagcaggtaa 3258781 aacgcgacaa tccgtgtcag tgtgctgcgg acagctttcg ggacaacctt ttccggattt 3258841 tttgtctctg caagcgttac accgataatt tctgtaccgc cgtaagagta gatgacgaca 3258901 agcatcgccg tgatcagccc tgtgccgccg tgcgggaaaa atccgccgtg gtctgtcagg 3258961 ttggaaaatc cggatgctgt atgatcaccg aatgatacaa ataagagcag caatcccaga 3259021 ataataaaga taataataac ggtaatcttg atcattgcca gccaatattc agtttcggcg 3259081 aagattttaa cagaaagcaa gtttacaatc gtgacgataa gagaaattcc taatgccaac 3259141 acccagatcg ggcagcccgg cagccaatat tgaatgaaaa tcgcagctac aacagcttca 3259201 gccgcaatgt taagcaccca cattttccag tagatccagt ccaaaaagta agcagcgtaa 3259261 tttcccaata cctgctggac aagatcacgg aaggttctgg cgttacggtt tcgaacagcc 3259321 atttccgcca gcccctgcat aataaacagc aaaataatcc cgccgagcag gtatgcgata 3259381 atgacagatg gccctgccac atcgatcgct gagctgctcc ccttaaataa acctgcgccg 3259441 attgctccgc ccagcgccat catcataata tggcgggacg tcatcgtgcg ttttaacgtt 3259501 tgattgtcgt ttttcatcct cttctacctc tccttctcgt tttcaaaaac aaaaaagccc 3259561 gccgtctcct acctaatcta atagataaag agacgacgag ccttcggctg accgcggtac 3259621 cactcttgtt gattcttcat gaagaatcct gcttttgacc tgtaacgaag gttagccgtt 3259681 aaaacatagg gaatattcaa tctattccgt tccgtcttac cactcccggg cgagttcaaa 3259741 gaagaatcag gctgcgtcgc accaccccgc agctctctgt tctgatcact ttcttttact 3259801 gctcccaatc tatgtgtttt agttttctga aaaactcaaa ttttatgatc tgaatatatt 3259861 aacataatat acgtgcttct cttttaactg tcaataactt cagagaaaaa agaaactgtt 3259921 attttgtccc ttttcgaatg gctttccaaa aggattctga ctcgtttcct aatgcgtaaa 3259981 ctgaaacacc tgctatttta tattgctttg ccagatggct tttcgtttga acggtttttt 3260041 cgttttcata ccacacgaca tgtttatgct tctttttgtc aacataagaa aacgtcatcg 3260101 agcctgattt tttgttgaat gccggctttg ctttttgttt tttgatgagg gatttgagct 3260161 cattccattc ccttattgtg ctggtacttc cgtcttttac atcccagtca tagccgtacg 3260221 cagggattcc catgatgact ttattggctt tgatcttttt gactgaaaac tgcagagagc 3260281 ttttgatcca gtttgtgctt gccactgacc ccggctcacc ccaaatgccg tgttcatcgt 3260341 aggtcatgac ttgtacgaag tcggcatatt tgccgatttt cgcataatca tacggccagc 3260401 tccagtcatc atttttatca tcggcgcttt tggccggaac ggataccatt gttttaatat 3260461 gtttcttatt caaagcctgt gagacatatt gaatgaagtt cgagtatgca gcgcggtctt 3260521 ctggatttac tgcttcaaaa tcgatattga ttccgtaata tgagtgcttt ttggccagtg 3260581 taattaactg atctgtgaat cgttttttcg ctgttttatt gctcatgacc cgactcgcta 3260641 aatctccgtc aaaatcataa atggcatcat tatagtttga aatgacagcc catgtcttga 3260701 tttttttctt tttcgcatat gtcagctgct tagttggggc atcgccaatg atttgtccgt 3260761 ttttttcaaa cgcaaatgta tcggttgcga tggcattcat gtatgtatga tatttcgtaa 3260821 gagaattgta tgaagccgta tccccagtcg tgtagcctac tgtcataccg gctgccttcg 3260881 cttctccttt tgtatacata aacagaacaa tcgcaatcgc cagtgaaacc gctatgatca 3260941 gccatttttt catcgcattt cctcctgtat caagtcatac tcttctcatc ggccaaaaaa 3261001 ttggaagttg aagttttttc aagcaaaaag cccggcatat gcctgccggg cttcctgagt 3261061 tcagcggtca gagacgagaa tatatgctgc ctttactggt ccatgcaccc ccacaactaa 3261121 atccatttca atgtcggctg agttactcgg tccggtaatg tagttgatac atgaaggaac 3261181 agtgacaccg ttcgcaatgt tttggcggat gatatcactg gcttgtgtca ttctcggtac 3261241 aatgcttgat ttcggcacga tcgcaatata agtcgttggc aaaaggctga cagagcggcc 3261301 gatgtctttt gaggagaaga ggacaaccgt ccccgactca gccaatgtaa tttcgctgaa 3261361 tgtaatccct acattggctt gctccgcttt tttaatattt tcctcgcctt tgtcagcatc 3261421 ccactcccag accggcgttc cttcactcgg ccagtccttg gtgagcaggc ttttcagtcc 3261481 gtattcttca aagcgggggt ccttcggaat gatgacaggg cctccagaaa agcggctgac 3261541 ttgctcgcgc agggcatcgt aaaggccggt tgaatccgtt tcaatcagct ctgtatggat 3261601 tttgacacaa tggtttttga gcactgtgac taagtcatcc gctgaataac cttcaagtgt 3261661 tttatattgc ggctgatgcg cccattcagg gactgccacg cctcctgttc ttcgttcacg 3261721 gcccaggctg gatgcgattc ggtttaaaaa gctctcttga ttctgaatgg ttcccttcgt 3261781 catcactgct cctccttcgt gcgttcactt gtttctctgt ccgcaaacca gtctctgaat 3261841 ctcgatttat gcggtgccgg gaagtcgcga atctgggtcc aatttttaag cgggccgggc 3261901 cctttcgaaa ttttttcgtc ctctgtaaaa ggcgtcatgg cggccggcgc ccattttgag 3261961 cccattttgt aaagcgataa ggaggatgcg ccaagtccga atgctttcat tgcaagcttt 3262021 tcactgatcg gcgccctgcc ttctttttcg acgatattct gacgatgctt gagtagcagc 3262081 tcatgaagcg ggattttgac cgggcaggct tctgaacaag cagcgcacag tgaagatgcg 3262141 tacggcagct ccttataatc gtcataaccg ccgagcaacg gtgataaaac agctccgatc 3262201 ggccccgagt agattgagcc gtatgaatgt ccgccgacat ggcggtacac aggacagaca 3262261 ttgatacagg cggcacagcg gatacattgc agcacagact ggaattccgt tccaaggata 3262321 ttggatcgtc cattatcaac gatgacaaga tggaattctt ccggaccgtc cacttcacct 3262381 tccagcttcg gacccgtcaa agctgtaata tagcttgtca gccgctgtcc gacagcactt 3262441 ctagtcagca tgctgactag cacttcaaat tcagaaaatg acgggacaat ccgctccatt 3262501 cccatgacgg taatttgtgt tttcggcaag gtgctcacaa gccgtccatt tccttcattg 3262561 gtcacaaggc tgacggaacc cgtgtcagcg atggcgaagt tacagccggt aatgccgata 3262621 tccgcttcca gaaacttttt ccggagaatg gcgcgcgcat gcatcaccag ctcttccggt 3262681 ttttctgtat gttgatagtc cagtctttct ttaaacacat cgcgtatctg ctctttattt 3262741 ttatgaagag cgggcgctac gatatgtgac ggcggatcgt gatcatcaat ctgcaaaata 3262801 tactcgccga gatcggtttc tacgacttca cagccttcct tctccagcac ctcattcaga 3262861 ttgatttcct ctgtgaccat tgatttagat ttcacaattt tcttcccgtt cttcttttga 3262921 atgacatccc gaatatagga agacgcctct tccgctgttt tcgcgaaata gacatgtccg 3262981 cctcttttcg ccacattttc ggcaagctgt ccgagataga aatcaaggtt ttcaaggaca 3263041 tgctgcctga tttcctctga taatgagcgc cactcctccc agtttcccag ttcttctgct 3263101 gcctctaggc gccgcgtccg cagacgctcc tgtgcacctg aaacagcgcc tctcataaat 3263161 tcattatcaa tcccctgtga tacccgctct ttaaaagcgt cagtaccgat tttcatcgcc 3263221 atgatccttt ccccctctga atccagtttt atctgctgtt gagcacttcg gcgatgtgca 3263281 tcactttgac attcttatct tttcggccaa gccgtccccc gatattcatc aaacagccgc 3263341 agtcagcacc gatcagcacc tctgctcccg tttcctccac acattcgact ttttcatcga 3263401 ccatctgctc agaaatctgc gccatcttga ctgagaacgt tcctccgaat ccgcagcagt 3263461 tatgtttgcc cggaagctct gtaaactgca ggcccttcac atggctcaac agcttcatcg 3263521 gctccttccg aacacccagc agcctagtca tatggcacga cgtatgtaag gtcgcttttg 3263581 tatgaagggt cgcgccgaca tcctctaccc caaggacgtt cacaataaaa tctgtcagtt 3263641 catacgtttt atccgccagc tttttcgctt tatcggccca tttcggatca tcctgaaaca 3263701 ggtgcggata ctcccggaac atcgttgtgc aggaacccga aggactgaca acatattcgg 3263761 aatcctgaaa cgtttcgatc atccgtttca ttgctttttt ggcgtcatgt acatagccgc 3263821 tgttgtaagc cggctgtccg cagcaaatct gcccttctgg aaaatcaacc tcgcacccaa 3263881 gccgctccag cagctcaacc gttgcttttc cgacatttgt ttgaaacata tcaacaagac 3263941 aagtgacaaa aagtgagact ttcatgatga acccctctct catccccaat atatgatcag 3264001 gtcatctgat gacctgagtt aaaataacta tatgaatatc gtacactatt ctgacaatgg 3264061 aaggaaagag ttttctaggg atattttcat ttgtggcata tcaaaaacac tcccgatctc 3264121 ccaggagtgc agtatatggt tagatccagc ccttttcctc agcgatgctg gcggcttctg 3264181 tccgattttt cgcattaagc ttttggatga tttctgagat atagtttcga actgtgcctt 3264241 gagataaata gagctccagc gtaatgtctt ttgttgtctt gcctaaagcc gcaagcctca 3264301 gaatttcttg ctctctaacg gttagcggat tttcgtctcg catcatatta aacgtcagct 3264361 cagggctgaa gacacgtttt ccctttacac attttcgaat ggcatcggcc agatcgtcaa 3264421 tttcaccgtc tttcagcaga tagccatgtg caccggcctt tacggcgcgt tcaaaatatc 3264481 cggggcgggc aaaggtggtt aaaataatga ccttgctgac gcagcctttt ttcattaatt 3264541 cctctgccac attcagcccg cttcgaaccg gcatttcaat gtccataatg catacatccg 3264601 gctccagctt caaaatagca tgtagcgcct cttccccgtt taatgcttgt ccgatgactg 3264661 tcatatcctc ttctaaatca agcaaagatc ccaaagcgcc taaaagcatt cgctggtcct 3264721 cagcaataaa cagacgaatc attcttttcg tcctccaatc attctgcttt tttaataagc 3264781 ggaatcgtca gtgccacaac cgttccgtta tggtctgaaa ccgttaatcc cccttcaatg 3264841 agcatgagcc gttcttccat tccccacagg ccattcccaa acattttctc cttcggcgct 3264901 ccctttccgt catcccgtat tacgatcctc attttgtcag caaattgaga aatggtgatg 3264961 gcacagtggg ttgctttgct gtgcttgata atgttagtca cggcttcccg catacacata 3265021 ctgataatat tttgagtgac gggagatatc actgaaaagt cgtcggctcc ttcgtattga 3265081 aaggtaatgt tccccgctct taatatgtgc tgaatgttta cgagctcctc tgttatcgtg 3265141 accgttctca tatcagaaac cagctctcga acttgcttga gtgcggagcg tgaactggtt 3265201 tccatttctt ttgcctcaag cttggtccgt tctggatcag atgcagccag ccgctgaatg 3265261 agctggcttt ttaatgtaag cagcgacagg gtgtggccaa gagtatcgtg aagatcacgg 3265321 gcgattcgaa cacgttcctc ccttttagag agttctttta tctgttcgtt ggcttgtgca 3265381 agcttagctt caagctcaat cctccgaaac atagaacgaa ttccgaatgg agaaatgagc 3265441 ataatgacga gaaacgggag aacagaaaaa agctcccgaa gcgagaccga attcgcgata 3265501 aattggtata ggcatggaaa aagcagtata aagattaaag cgcagaacgc acggttaaaa 3265561 ttcgttttct ctttgtaata accaacaaag tttgccggaa aaaaacctaa gtatatatag 3265621 gtgatattgt aaaacacact atacatcaaa ataaccgcca tttgcacgat aagccaatat 3265681 gtaaacgaag ctttgcccac gctgcagaat aactggcgat atgccgctac aaaaaggagc 3265741 agcataccat atccgatccc ctgtttgacc cctgattctt ttaataaaga gaggaacggc 3265801 ataatcgtat acaccagaaa gatataaggg aaaaacccga attccttcgg gaaaatagat 3265861 attgcctttt tcatgtatta caccgcttct tgttttcttc ttatatattt agatagtagc 3265921 atgaagagca tcatataagc gattaatatc agaatatttt tccaagtcgg actcccaccc 3265981 cggacaagtt cccacgctcc gctcccgaaa tgataagacg gaagccactg gccaatgctc 3266041 tgcatcatgt caggcatgac ctcaaacggc atccacatcc ctccgcctaa agccagcagc 3266101 atataaagca cattactgat tccggccgct gtttctactt ttctcatgag gccgattagt 3266161 gtgcctaatg ctaaaaaagg caatgcgcca aacaaaatcc acagtccgct catcatccat 3266221 tcaaacggtg acaaggcaat atcattgatg attgcgccga acagaaatat gacggtaatt 3266281 gataaaacgt gaatgacact ttggccgatc atctgagctg ataaatagat atgatccgga 3266341 agaggcgtaa ggcggataaa ggcggcccag ccttgtgacc gttcttgtac cattcggatg 3266401 ccaagcgtca tgatagagga acccatcacg ctgaagactg tcatcgacat caggtaatgg 3266461 gcttcccatg cacgttgatc agggacgttg gtattcacta catttgtaaa gaaataataa 3266521 aaggcaatcg gcatgatcag agaccaaagc acaaagtact tgttcctaag cacccttttc 3266581 atttcagcga tgctttgctt ttgcagcacg ttcactcaca tcgcctccct gttgccgtca 3266641 gccagctggc gaaatgcctc atcgagcgtt gcttgctcaa ttcgaatatc ccgtgcatgt 3266701 atgttttctt gaaagatcag cgccaacact ttgtctgtat ttgatgtctg gatgatggtt 3266761 ctctcatgct cgtggatcac tctctcgact tccgggtgac aagacagcct ttccaatgat 3266821 tcacttgaat gaagcgtaaa ggaaacagac tgtttttgaa ttcttgagcg gatttgcatt 3266881 ggtgagccgt ctgcaacaag ctgtccttca gtaaaaaata ggattcgctg tgcggcatca 3266941 tctgcttcct gtaaataatg agttgaaaaa ataatcgttt ttccttggtc cgacagtccg 3267001 tgaatggtct gccagaatcg gtgtcttgat gaagtgtcca tgccgactgt cggttcatca 3267061 agtataagca gctccgggtt cccggcaaga gccaaagcaa agctcaaacg gcgtttttgt 3267121 ccgccggata atttttctgc tcttgttttc aaatcttctt tggtgagtgc tgttaacgaa 3267181 acgagttctt tcatggacaa tggattcgga taatagctcc ggaagagttc aaggatttca 3267241 tccaccttaa ggcccggcat gacacttact tcctgaagca ttacacctat tttttcacga 3267301 acctgttgat catcgggaac ccggttaaat agtttgattt ctccctcact cggtttcagc 3267361 aatcctaata tcatcgagac gacggtcgtc ttccctgccc catttggccc gagaatggct 3267421 gcaatttctc ctttttcaat actgaagctg atgttgttta cagcggtttt tcgctggaaa 3267481 tgttttgtca cgttgcttac tgttactgct tctttcatca catgagcacc tcctgatcgt 3267541 ttacattgat tgtaaaatga cggagaagac gatgttagta tggggtgtca tgatgatgga 3267601 gtgacaaatg tcattttttt ctcaccccgg tgtctaggca atcctcctcc tgcatcttcc 3267661 aattcatcca tcttttctat ctcccatgtc ctctttcttt taaactgctg tgacattcat 3267721 agaaagatac actcttcaaa ccatccgagt gttatgatag aaatattgaa ctttatatta 3267781 ctttccggct gaaaggagcc aatcatgaac gaagcgattt tgtctagaaa tcatgtgaag 3267841 gtgaaaggca gcggcaaagc atctatcatg ttcgcacctg gttttggatg cgatcaaagc 3267901 gtgtggaatg ccgtggcacc tgcctttgaa gaagatcatc gggtgatttt atttgattac 3267961 gtcggttcgg gacattcaga tttgcgcgca tatgacctga atcgttacca gacacttgac 3268021 ggctatgccc aggatgttct tgatgtttgt gaagctttag atctgaagga aaccgtgttt 3268081 gtgggtcact ccgtcggggc cttgattggg atgcttgcat ccatccgccg cccggagctt 3268141 ttttcccatc tggtgatggt ggggccttct ccttgctatt tgaatgatcc gcctgagtat 3268201 tacggaggat ttgaagagga gcagctcctt ggcttgctgg agatgatgga gaaaaattat 3268261 atcggctggg cgactgtatt tgcggcaacc gttctgaatc agccagatcg gcctgaaatt 3268321 aaggaagagc ttgaaagccg tttttgttct actgatcctg tcattgcccg ccaattcgcg 3268381 aaagcggcgt ttttttctga tcaccgagag gatctttcga aggtaacggt tccctctctt 3268441 attctccaat gtgcagatga tatcatcgca cctgcaacag taggtaagta tatgcatcag 3268501 catctgcctt atagcagtct gaaacaaatg gaggctcgcg gacattgccc tcatatgagc 3268561 catccagatg agacgataca gctgatcggc gattatttaa aagcacacgt gtgatatagg 3268621 aacgaaaggg atagaggtga ccctcttaga tggacaaaca attgaatgat gcaccatgcg 3268681 gtttcctcgc tttgtcagaa gaggggtcga tcatagctgc caaccgcacc cttatcaaga 3268741 ttctggatta tgaaccggag caggttatcg gccagcacat gaatatgatg ttgaccattc 3268801 ccgcgcagct tttctgccag ctttattttt ttccgctttt gaaattggag catcacatcg 3268861 aagaaatata catttccctg aaagcaagag atggagaaga aattcccgtc cttatcaatg 3268921 ctattgcgag acacgatagc ggggcttctg tctttgattg tgttctgatt ccaatgcgaa 3268981 agcgaaatga atatgaaaat gagctgctga tagccagaaa tgaggctcag gaagctttgc 3269041 ttgccaaaca gaaagccaat gcggagttag aaattgcctt ggaaacgctg aaagcaaaac 3269101 aagaagaact tcttgagatc aataaacaaa atcaacaatt taaattaaac accaaaagag 3269161 agcttgaact cgccagaaag atccagaaaa actcgttgac tgaaccgatt gtaaacgatc 3269221 aggttcagat tgactcttat tacaacgcat cgagtgaatt gtcaggtgat ctttacggat 3269281 attatcaaat cgatgaacac cgttacggca ttattatcct tgatgtgatg gggcacggaa 3269341 tttcatctgc attgattacg atgtctcttc atcctttgtt ccagcgccag atcacgcaag 3269401 gtctcagccc cgttaaagtt atgaaggaat tggaccggca ccttcacagc ttgtttcaaa 3269461 atgatgagga agcaagacat tattgcactg ctatttatct cgagattgat atagcacggc 3269521 aaagaattga ttatgtcaac gcagggcatc cgccggcact ttggcaggac gatagcggaa 3269581 ctcaacatct gcttcacgcg acctcgcctc cgatcgggat gtttgaagac ttagagtttc 3269641 agtcaagcag cctttcatac acggaggacg gaagattgct tctgtatacg gatggcgtga 3269701 tggatcctac ggcttcatgt tatttatttg atttactaaa ggatcatcct gattcgccaa 3269761 tcgctgacct gaaggagaaa atccttacat cactgcagca tcaaaaggaa gctcatcata 3269821 agagtgatga cgaatgtttt atattagttg atgtaaaata aaatgatcca tgagacataa 3269881 caatgatttg ttacatctca tggatttttt tgtttcagcg tttctttgga atatgtcctg 3269941 actccgcata ttgaaacacc tgcaaggaag gcagcgggtg tccattaaaa tcaaataaag 3270001 cttgattatc tacagcactt cccccatacc acttcccggc gtcttcaggg tcgtattcag 3270061 cagcatagct ggacgcccac cctgacccgt atgtttccca taacactttg tttttctcta 3270121 tctgtgtctt cggcccgact ggaatccacg ccggctccca gtagaaaaca ccaagtcctg 3270181 ctttgcccgt attcgccact gcctccatta catctcttac tgcagttgcc tggccttgaa 3270241 cagaaattgg atatggcaac gtctgcccgc tttttggtgc tgtatttcca tgcccatcgc 3270301 catcctcagc ggtataggtg tacgatgtct ccgccaccat gacttttttg ccgtacgtat 3270361 tggcaacagc cttcagcacg gaggtcaaat tttgtaatgt gccatgccag aaaggataat 3270421 aggagctagc aaacacatca taatccactt tgtttttgct gagtgtttct gcaataaatg 3270481 aataccttcc agccgtttca ggattggtaa aatgcagggc gaccaaaata tttgaatttg 3270541 tctccctgac cgctcggctt ccttcattaa ataattggca catcttcgtc caatcagtct 3270601 caccggcaaa tcctcctgtt gtttcatttc cgacctgaac catgccgatg tcaacgcctt 3270661 ccttgatcat cttttgcagg ctttgtttcg tatactcata gagctttgct ttttttgctt 3270721 caaagctgag attcgcccag gctttgggca ccttttgttt cgctggatcg gcccagaaat 3270781 cagagtagtg aaagtcggcc agcaccttca ttccgttcgc tgtcgctctt tttccgattt 3270841 cgatggcttt ttgaacatca ttgtttcccc cgccataccc gttgccattt gaatcatacg 3270901 ggtgattcca gatgcggacg cgaacatagt tgaccccagc ctgttttaaa gttgtaaaga 3270961 tatcctggcg ttttccgttt gtattgtaaa aggtgacacc gctgttttcc aaagcaataa 3271021 cgctggatac atctgcccct ttgataaaat ccttgttcat cccctctact tttttaacaa 3271081 aaagatcctc tgcccgaagc tctgacacgt gcttctcctt ctcaatggca gcggcatatc 3271141 ctgttgaact acatgcactc cacacgatgg cagccgcaaa gaacattttc actttgcttt 3271201 tcatgatttc atccccccaa gacttagcaa gcgttttcat tctatagaaa aaagaatccg 3271261 cccatatcga gcggagcatc agcctaatgt gtgtttacga caattctcac ttcatacttt 3271321 tccatcgtca ggtcgcctga caatatgtct cctgtcatta tgtccttcac actctgatca 3271381 aacgtgacca gctgtttttc ttccgtgaaa ttcatgacaa aaatataatc attgtcctga 3271441 tcctgcctcg cttgtacgga gacgcctttt ccgtgccgaa ccggaaaaac tggagagaga 3271501 gacaggtctg tgatcagacc ctcatagaaa tcacgctgaa attgatcctc caaacgcgcg 3271561 ccgataaaat acgccttgcc ctgctgatac tcatggcttg tgaccgctgg cgtgcgcgca 3271621 taaaaatctt cttgatacac cgcttccact gaagctgtct ttacatcaat cacggttgca 3271681 taatccttca tttcatatat ttggctgcgg tagctgacag cgtttcgatc cttcggatac 3271741 agggtgtccg tttcaagagg ctcaactcca aatatagctt gaagatccgg atgccatccg 3271801 cctgtgtatg ttaagtcatg ctcattcaca accccgctga tatacgtcat gactaaggtg 3271861 ccgccgtcag ccgtaaacgc ttttaaacgg gaaacggtgt cctcgctgat taaatacagc 3271921 atcgggacga tcagcagttt atatggtgaa aagtcttgtt ctttcgtgat gacgtcgaca 3271981 gggatatcgt gttcccagaa tgtgcggtaa tgctgctgaa gcgtttgcgg ataacgtttt 3272041 gtcgccttcg caaacccctg agcatcctcg agcgcccaat gattttccca gtcatataaa 3272101 atcgcggttt gagccggcct cttcgttccg acaacttcgg acagccgttc caatgtctcg 3272161 cctaccttgg ccacttcttg aaagacgcgg ttcttcgggc tattgtcatg atccacaacc 3272221 gctccgtgta atttttctga tgacccccgt gatttgcggt attggaaata gagaacgctg 3272281 tccgagccgt gggcaatcat ttgcatggat gacagcagat tcatgcccgg gcgctttgcc 3272341 ttgttgacgt tatgccaatt gaccgcgctt ggcgtacact ccattaataa gaagggctgc 3272401 tgcttcaagc ttcggtacag atcattgata aagccgacct tcatcgccaa atcagctgtg 3272461 ctttcccagt cattgtgcca gacaggataa gcgtcccagc tgatggcatc gacatgcttt 3272521 gcaaatttgc tgtagtcgag gccctgatac gggatcaaat ccggtgtgtc agccataaaa 3272581 ttcgttgtga tagggatatc aggcgtcaat tctttcagcg gaatgatttc attttcataa 3272641 aacgaaatcg tttgatcggt gacgaaccgg cgccaatcta aattcaggcc atgcaagcca 3272701 ttttcaccga tcggcgaagg gctttcaatt tgtgaccagt cattgaacgt atggctccaa 3272761 aaaggggtcc accacgcatg gttcaatgtc ttgaggctgt tgtcatattt cgatttcagc 3272821 cactcccgga aagcatgctg gcataaatca cagtggcaat ctcccccgta ttcgtttgaa 3272881 atgtgccaca ttaacagcgc cgggtgatgt ccgtatcgtt ctgctaataa gcggttgatg 3272941 tgccgtgttt tttctcggta gactttagat gtgaggcagt ggttgtgcct tccgccgtgc 3273001 agctgtttga cgcgggaggc attgacgcgc aaaacttccg gataggtttg cgacagccag 3273061 gccggacggg ctccgctcgg cgttgctaat atgacccggc cgcctatact gtgaatccgc 3273121 tcaaaaatat catccagcca ttcaaattga tatacgccct cctccggctc aagtgcgctc 3273181 catgcaaaaa tgccgacaga aaacgtattc gtatgagaaa gcttcatcag tttgatatcg 3273241 tcagctaaaa tatcgggccg atccagccac tgatcggggt tgtagtctcc cccatggagc 3273301 ataaattttg cttttgttac gtgcgttttt tcaagctttg acatcacatt ctcctccttg 3273361 ttctcttagc ccttcgttcc gcctgcggtt aatccggaca caaaattctt ttgcagcata 3273421 ataaagatga cggcaaccgg tatgctgata agcagggctc cggccgcaaa tgtcgtatag 3273481 ctggccccca tgacatcatt cactaaattg aatagaccga cgggcaatgt atatgattca 3273541 ggcgttctca atatggttga ggacagcaca aaatctccga gcggaccggt aaagccgttc 3273601 atggccacga ctgccgccat cggttttgat aatggcagaa tgatctggaa gaagattctg 3273661 gtgctgctgg ctccgtcaat cttggcgctt tcgtctaaat ccatcggaat ggaatccatg 3273721 taccctttca tcaaatacgt attcatcggg atcaggccgc cgatataaag caagattagc 3273781 agccagtggc tattgatcat tcccaagatt tgcgccagca caaacaaggc aattaaagct 3273841 gaaaactgag gaatcatctg cagcaataaa aagagcgtta aagcgtattt cctcccttta 3273901 aaccgaaagc gcgaaaacgc ataggccgta aacgtcacac agagcaaaga ccctgccatt 3273961 gtaaacaggc tgatcttcat agagttgaca taccactgca catattgaag gctttccttg 3274021 cccgcaaata attccttgta atgatcgaat gtcggatgct tcggaatgat ggatgtactg 3274081 attaagctgt tgccgggatt aaagcttgcg cctgccgtcc aaaggagagg ataaacaatg 3274141 atgaccgcca taaaggctag caacaagtaa gagaaaagga gacggatata tcttctgact 3274201 ttcatatctg ccagcatacc ttatgcctcc tctttaaaag actttgtctg tctgaactgc 3274261 cacaatgcga tggagataac aaatacagat aataaaatgg ttaaagccgc agcaagtgaa 3274321 tattggctgg actgcattgt caatttataa atccatgaaa cgaggatatc tgtcccgccg 3274381 gctgttgatc cggttacagc cggacctccg ccattgaata gatagataat attaaagtta 3274441 ttaaagttaa acgtaaactg agtaatgata atcggagcca ttgcaatgaa caccatcgga 3274501 agcgtgatgt atctcagctt tgaaaagaca gaagcgccat caatcgtagc tgcttcatac 3274561 agatcgtccg ggatggattg caatacgcct gttgagacga gaaagatgta cggaaatccg 3274621 agccagccct gcatgagaat caatgcaagc ctcgaccaat tggcatctgt catccacgga 3274681 agcggatcta tcccgaagaa agccaagatg tcgtgattca tcgcaccgaa gctatcatta 3274741 aacagtcccg caaaaattaa aatcgtcaca aaaccgggaa cggcccatgg caaaatcaga 3274801 atcgtccgaa aaaaacgttt aaaccgaagg tctttctggt taacaatgat cgcgagaaaa 3274861 atccccaagg tgacttgcag tgtggatgca gcaagtgtcc aaaccaccgt ccaagccagt 3274921 acatcaaaaa aagtcgacct ccaaatatca actgtgaaaa tatttgcgaa cgtttgaaaa 3274981 ccgacccaat caattaattt tgcaggagga gaatgataca aatcatagtt tgtaaacgct 3275041 aatgcaaagc tgaataagat aggaaagatc acggcgaaaa ttaaaataaa caaagatggg 3275101 ccgctgacga cataaggata gccctcagaa atgatatgct ggtattgttc ctttaaggaa 3275161 cttaatggct tattttcatc acgctgtttt ccgctttgga acgcatcgcg aagatttaca 3275221 taatacaccg caaggccaaa gcaggtcacg atgacagcaa taatcccttc cgccagcaga 3275281 aaaacggaat tatcccgcgg cacttctgtt cccagtgtaa agattcccca aaaccccata 3275341 ttgagcagat ctccaaagac cgcaaaaaac gatgcgccta agaaaagaaa gacaatacct 3275401 tttatccatt gcttgttata aaattgcccg agtcccggaa tgatagaaag caacaaagcg 3275461 acttgacgat gctgcaccgt tttcacctct cttacaatac aaatctagct ttctctttat 3275521 tttccgctgt gctttgcctt aatttgtcct ttggccgttt cagctgcttg atccaatgct 3275581 tgtttcggat ctgccttccc tgttgcaacc gtctgtaatg ctgaatcagc cggcgtccat 3275641 atttcattca tttccggaat atttggtgtt ggctctgaga aacgggattg ttcagtaaca 3275701 gcccgtgccg cctcgctttt cataatagcc gggtcattgg ctagggattt cacagcagga 3275761 acttctttcg tttcttcata tcgtgtttta gaattttttt catttgccag gaaaacggct 3275821 aattcttgcg ccagctcttc attctttgaa aatgcactga cgttgtagct tttgacgccg 3275881 ataaaggagc tcatgttttt cccattttcc agcttcggca gtttcgtaat gccataattg 3275941 attcctgcat tcgaaaaggc ttctacattc catggaccag aaataattgc ggcggctttt 3276001 ccttctgtga acagcgattc caacacgtta atcccttgtt ctccaataat gccagccggg 3276061 aacaggccat ctttgtaaaa cttctgaatc agcgccgcac ctttgacagc tccttcatta 3276121 ttgattccaa tgtctgacgg gttatagctc ccatctttgg cctttccaaa aatgtatccg 3276181 ccatatccgc tcatcacact ttctgcataa taaatttgat cgaatagggc taaaaagcca 3276241 aatttgctgc cgtcagcagt ctttttggaa tagtcgtacc actcttccag cgttttgggc 3276301 aattcctttt ctgtgatgag atctttgttg taaaaaagca cagtcgtttc gaccgctttt 3276361 ggcagtccat aaagcttttg atctaccatt tgagactgaa tggaagcgtc agtataaagt 3276421 gattgaacgt cttttttgac atgtaattcc ttgagtaatc cttccgtgac agcggttccg 3276481 atttggtccc ctggcattgt taacacgtca gggcctgtgc cggccggtcc atccattcgc 3276541 aaatcttcaa tctgcttggc atacggtttt tcaacgactt tgaccttcac atcatgctct 3276601 ttttcaaatg cagccacagc gtctttaatg ccgttgctct tttctttatc ctcccataca 3276661 acaagctctg acccttttga actcgatttg gcgctgctgc tttcctttgg gccgcaagcc 3276721 gccaaggata aactgacagc tgcgcagagc atgaatacgg aacacttttt tgccattttc 3276781 attgattgtc accctttcgg taggaatgaa agcgctttaa agataatata gcatgcctga 3276841 gaaaatgtgt aaacaaacta tttacttcat agagtaaatt tttttaccta aataaaaaat 3276901 gacttagtgt cctaagtcat ccttaattca tactcttcct gacgattaat tctgcgccca 3276961 catataatgt ttttaccgtt cttctcttgt cctgcacttg ttcaagcagt aattgaacag 3277021 cgtttttaca taattcatgt atatcaatat gaaacgtcgt cagaggaggc gagacatact 3277081 tcgcgaagct gatgttgttg atactcacaa tgcttaccct gtttggtatg gcaattcctt 3277141 tttcgttcag ggcttgcaga cagcccactg caatcgggtc cgctgcaatc ataaaagcag 3277201 tcggaagctg atcgcctaat gtgtcgatcg ctgctgacat caggcggtag ccgttttcta 3277261 cagagaatcc gcgatgacag aaaatatagc gctcgtccag catggctttt tccctcatat 3277321 aggatctgaa ggtttgttca cggatgtcca tttcatcctg attggtattc ggatttttgt 3277381 atgtgccgcc gataaaaccg atgctcttat gccccttctc agtcaggatg tttaccgtct 3277441 tccttgtcat ttgtgccaaa tcgggcctta ccgagtcaaa atgatcggga tcaggagttg 3277501 aatcgatgaa cacgccgttt tcagtgagat ttctgaggaa agccagctct tcatctgaaa 3277561 atgtgccgac ggcaataaac ccttccgtat gttcaggaat gctctcgatt ccatccgcta 3277621 ttttataagt ggtcatatcg acattgaatg ctttcgccag tttctctact tctaatctca 3277681 tcgttttaaa atagacatct tctaattctt ctttatctgt cagccaatat aaaaacgcaa 3277741 tatgtttcac cagcggcctt actgtttttt tgcggtaatt gagcttttcc gccgcttcat 3277801 agattttctc ccgtgtctca tcaggaacag aaaggctttc atcgttattt aaaacgcggg 3277861 aaacggttga gattgaaaat cccgcttcct gcgcgatatc tttaattgtc gccattgtat 3277921 ctgcctccat tattcagctc gcattgtttt agtaaaatat tttactttct ttttcacaaa 3277981 tgtcaagtgc acaaagccct ctggctgcca tgtaaaaaga ctgaaccatt tgcggctcag 3278041 tctcagttgt tcgtatcatt cggaaccggc ggaattgccc gggaaatgag ttggttattg 3278101 cacattttcc tcgaaatatc ccgaaagcac atcttccaca ttcgtcaaat gcgccagcat 3278161 ggcggcttcc gcctgtgcac cgttcccggc agccacagca ttgtaaatcc gttcgtgctc 3278221 ctcatacagc cgctgaacgg aggtcttctt ggaaaacagc cagattttcc tcgtttccct 3278281 cattgtttcc agcagcaatg atgacacgtg attcatcaag tgtttaagaa gttcattttg 3278341 agaagcgtcc gcaagcgcaa gatgaaatgc aaagtctgct ttctctccca gctccccgtc 3278401 cgcttcaatg ctgcccattt cctttagtgc atcctgaatt ctttcgagat ctgcttctgt 3278461 ccttttttca gccgctagtg aagccacgcc gatttcaagc agttttctga cctcgagcag 3278521 ctgcttgacg tcctcttttt tcatcagaag ggcggctgag agcggctgag aaatttgatt 3278581 gagctcaaat tccttcagat acgtgccttc tccctgtttc atttcgacaa gccccatcgc 3278641 ttttagcgca gaaagtgctt cgcgaaccgc tgaacggctg acttgaaagc tctcagcaag 3278701 cgcctgaaca gagtccagtt tatcccccgg cttcaattcg ccatttttga tcatatctaa 3278761 tagggcatcc gctacttctt catatatttt tttgttttaa tctgtttata tttcaatgca 3278821 attcaccccg taacttgtag gtctggctgt ttacgatcta ttatactctg ttttgtgggc 3278881 cgccaaaaga ttttgactat tttgtcaaaa agtcttgtac tttgattttt ttcaaaatat 3278941 aatgctaggt aactggtctt attacccagt catcagatga tcatatcatc tatagaaacc 3279001 gcttacatat ggcgccagtt tatgtttcaa ggaggggttt gggatgcaat ggacacaggc 3279061 atatacgcct atagggggaa atttgctatt atcagcgctt gccgcacttg taccgattat 3279121 tttctttttt tgggcactcg cgattaaacg gatgaagggg tatacagcag gcttggccac 3279181 attggggatc gcccttatca ttgctgtatt ggtttatcgt atgccggcgg aaaaagcgct 3279241 gatgtccgcg acacaaggag ccgtatacgg attgttgccg atcggctgga tcattgtgac 3279301 gtctgttttt ttgtataaaa tcactgtgaa aacgggacag tttgatatca ttcgcagctc 3279361 tgttctctcg attactgatg accgacggct tcaagctctc ttgatcgctt tttcattcgg 3279421 ggctttttta gaaggggcag caggcttcgg agcgccggtc gccatttctg ccgcgctgct 3279481 ggtcggtctc ggctttaatc ctctttatgc tgcggggatc tgtttgatcg ccaatacggc 3279541 gccggttgcc tttggggcaa ttgggattcc aattacagcc gtagaagggc cgacagggat 3279601 tccggcgatg gagatttcgc aaatggttgg gcggcagctg ccgtttttat ccgtatttat 3279661 tcctctttat ttaatcatca tcatgagcgg gttcaggaaa gccttggaga tctggccggc 3279721 gattctcgta tccggtgttt cctttgctgt tgttcaatat ctcagttcca attttttagg 3279781 gcctgagctg cccgatgttt tgtcagctct tgtttcaatg gctgcgcttg ctgtgttttt 3279841 gaaatggtgg aagccgaaaa caacattccg gtttgccggt gaacaagagt cggccgcctc 3279901 aattgaaacg gcgcgcacaa atccggcggc gcctgcatac agaggcggac agatttttaa 3279961 ggcttggtcg ccatttctgc tgctgacggc gatgatttcc gtatggggca ttccatctgt 3280021 caaatccgcg ctgaccgggc attatgaagg ctctgcggtg ttcttgaagt ggctgaatgc 3280081 tgttggagaa aaactgactt tttcccccgg tgtgcctttt ttgaacaatc agattgtcaa 3280141 tgctgacggt acgccgattg aagcggttta caagttggag gtgcttggtt cggccggcac 3280201 cgcgatattg attgccgcag tgctgtcaaa attcatcacg gcgatttcgt ggaaagactg 3280261 gggaaccgtt tttaaagaaa cagtccagga attgaagctt ccgattttga ccattgcttc 3280321 tgtcgttggt tttgcctatg tcaccaactc ctcgggaatg agcacgacac tcgggatgac 3280381 actcgcgctg acaggttcga tgtttacctt cttttcgccc gttctcggct ggctcggcgt 3280441 cttcattacc ggctcggata cttctgccaa cctgctgttc ggcaacctgc agaaagtcac 3280501 cgcattatca gtcggcatgg accccgttct gtctgtggcc gccaactctt caggcggtgt 3280561 cacaggaaaa atgatttcac cgcagtcgat agcggtggcg tgcgccgcgg taggactcgc 3280621 cggaaaggag tcagatcttt tccgctttac cattaaacac agtctgtttt tgctgctgct 3280681 cgtctgtatc atcacctttt tgcagcatca cgtattcagc tggatgattc cttaaaaaaa 3280741 tcctcccgtc tagggaggat tttatttata tcgctttctc gctgccgatg acggaatatt 3280801 catttgatcg cgatattttg ccacggtgcg tctcgagatt tggatgccgt gttgttcata 3280861 cagcaaatcg acaagctttt ggtctgaaag cggttttgtt ttgtcctctt gattgatcag 3280921 gttttccaga tgcgttttga ctgcataatt cgacgcatct ccatcacctg aagcctcggc 3280981 ttttgctgag aaaaagagtt tcatctcaaa cagcccgtaa ggcgtttgta ttgttttccc 3281041 tttaatggcc cggctcacag ttgattcatg aaggcttaga cagtctgcca cctctctgag 3281101 agtcagcggc ttcattgcgc ttcgcccttt cagaaagaaa tccttttggc gtgtgatcag 3281161 ttcattgata attctcgtga ttgtctgttt tcgctgccgc agcgcgcggc tcagccagcg 3281221 ccactcctga tatttcgcag ataaatagga gacagtatcc tgacaggagc cggatgataa 3281281 aagcgttctg tactgcggat gcagatcgat ctcgggaaac gagcgggtat tcagttccgc 3281341 tgcgatgtgc ccatttttta cggtgataaa aatgtcaggc tcaatataca catcttgctc 3281401 tggccgggca aacagaaggc caggtctagg atgaagagcc gcgatatcat ctgagatatc 3281461 ttgaatggta tgaagcggaa ttcccgtctc tactgaaagc gttttccatt ttttttgcgc 3281521 aaaagcatca aaatgagctg aaaccagcat ttccgcttgt tcatttctgt tcggcagccg 3281581 ctgtaattga agaaggatgc attcctgcaa agatctcgcg ccgattccag ccggttctaa 3281641 cgactggagt tttgccaaaa cagcctccgc ttccttggcc gatacagata atcgccgtgc 3281701 tgcctcctct atatcttctt ccaagtaccc gtttgaatca agcgaatgaa tcagataatt 3281761 aaaaatcttt ttttcagtgt ttgtcagatt catatcgagt gactgctgtt ttaacgcatc 3281821 ctgcaatgtt ttttgcggat tacttaattg aaggcccgct tcctgtgcat tcatcctgtt 3281881 tttgtttgtt ttatggtaag atagtggcgg tgtgtctgtt tcctttcgtt caataagagg 3281941 gttttccagt gagagctcat caatgtactc ggcgagttct gccgaatgat agccaagcag 3282001 cgtgatggcc tgcctgagct cctgtgtcag ttgaggcttt aatacttgta cttgctgaag 3282061 tttcatatcc atcttgctca ctcccctttc ttcattgtac atgattgaga tcacaccgta 3282121 tacatttatg aaaaaggagc tgccaaagaa atgtctgaac ttttttccgt cccttatttt 3282181 attgagaatt taaaacagca tattgaaatg aatcagtctg aggataaaat ccacgcgatg 3282241 aacagctact accgttccgt cgtctcaaca ctagtgcagg accagctgac gaaaaacgca 3282301 gttgtcctga aacggattca gcatttagat gaagcataca acaaagtcaa acgtggagaa 3282361 tcaaaataaa ccttccgctc acatgtgagc aggaaggttt tccttctttg aggcgtgctg 3282421 gatgagacgg gtgcttggca cgccttccat ccaggtatga aagtaattgg cgtttttccc 3282481 gtaggaatta tcaatgaccg tgttttcttt ttgaagaaga gaagacagga tgtggccgtg 3282541 cagccttgat gtttccaccg attcgtaacg gctgaaaaac cgaatcgctt tttggacgat 3282601 ataatccgag tatttttccc atatatacgc aatgggcaaa gggttgcctg cttttttatt 3282661 caagacgttc agcgtttgga gaaaagcaat cgtccggcgg tctgaagctg acagcaccgt 3282721 gcgccagtcg tagctttccg cttctgcgtg ttcctgaagc gcctggtttg cttcatgatc 3282781 tgttcggata aatctcagct tttgattgga cggctgctgc gtgggaatga cgggaaacag 3282841 ctgatgagcc atatcaggca gaagctgaat gtgatttgtt gtaaaatagg cctgtgccgt 3282901 agcataggag gctttttccc ttgtcatgat gtgaaggttc gcatgcttag aaaatatctc 3282961 tgccgtccgc ttgaggttgt ctttgttttg aaaataaatc gattgcggca ggatcacaat 3283021 tttgtggttc ggataggttt ggacgatttt ctctctaaag ccttgataat acggatacag 3283081 atccccgaag tttccgcctc cctggcagac gatgatgaga ttcggatcaa gctttcgccc 3283141 gattgggaaa ttgtctggat tccagcgttt tctgacccga atcccgtgtt ctttaaagaa 3283201 ggcttctgtt cctttcataa taaataaatc ccctacattc ccatatagag gatagtcagc 3283261 atatataatc tctgattgtt tcggaatgac gtcgagcagc ccggacagtt tctgtttcag 3283321 gctgatcatc gaatgcttgc tgtccatttc ttcacctcga cagtatggaa taagtgcagt 3283381 agcacttcaa tgacccggcc ttgctcatct tctgtcatat tggaccccga tgggagacag 3283441 attcctcgct tgaacaaatc ttcgcatacg cttcctgtat cttcatgaga ataaaataaa 3283501 gccggatcga acagcggctg ggtatggagc ggcttccaca gcggacgggc ttcaatgttt 3283561 tcttcagcaa gacgttgaac tatgtcatat gggctgagcc cgttatcaag tgtgagcgtg 3283621 gtgagccagc gattggatac gcctgctgcg tactctggca taaagcggac gccgtctaag 3283681 tgaccgagcg catttttgta tctcgtgaaa atggtccttc ttttctccac tcgctcatcc 3283741 agcacctcaa gctgggcaat gccgacgccg gctaagatat tgctcagcct gtaattatgt 3283801 ccaatttcac tgtgctgata atgaacagcc ggctctcgtg cctgcgaagc gagaaatctt 3283861 gctttttcaa ttgcggcttc atcatttgaa acgagcatcc ctccccctga tgtggtgatg 3283921 attttgttcc cgttaaatga aaaaatgccg aagcgcccga atgttccgct ttgcttccct 3283981 ttatagactg tgccgagaga ttcggctgcg tcctcaatga caggaactcc gtatgcatca 3284041 cacaggctta cgatttcatc cattttcgcg ctctgcccat atagattgac ggcaattacc 3284101 gcttttggca gtgttccgtt tcttttcgct tcctccaatg ctctttcaag ggctgtcggc 3284161 gacatattcc acgtatcagg ctcagaatca ataaagacgg gcaccgcttt ttcatataga 3284221 atcggattgg cggttgctac aaatgtgaag gactggcaaa acacgctgtc accttctttt 3284281 acctcaagca aacgcagcgc gagatgaatc gccgccgttc ctgagccgac cgcagctgct 3284341 gcttttacac cgactcgttc tgccagctgt tcttcaaatg aattcacgag cggcccaagc 3284401 ggcgcaatcc agtttgagcg aaaggcttct gaaatatagt gctgctccct gccgctcata 3284461 tgagggggag ataagtagat ttttttatgc atagaatcat cctttgtttg atgtttgaat 3284521 ggaagaaatg atgcgtgccg gagcaccggc cgccgttacc ctgtccggta tggaacggat 3284581 caccgcggag ccggctccga caatgctcca agccccgatt atgatctgcg gtatgacgga 3284641 tgcaccggtt ccgacgtgag cgccttcctg aacggaaacc gctcctgaca gcgtggcacg 3284701 cggggacaga tgaacgtaat cgctgatttg attgtcgtgc tctgccactg cacccgtatt 3284761 gatgatgcag tgggcgccga tgcgcgcatc cgcctgaatg atcgcgcccg ccataatcac 3284821 tgtcccttcc ccaatgacag ccgacttgct gacgatggct gacgggtgaa tcaatgtaat 3284881 aaaatcatct ttccccagtc ccagtcgctc cgccagctgt tttctgacac tgttattccc 3284941 aacagcaatc agaaacagca catcaggaat gagcctgcgc agttcagtaa cggctttcgg 3285001 cggtcctgtg taccattctt ttccgccttc gaacgttttg aatttatcat ccagcaccgc 3285061 ggctaagcgc gtatctgagc gggcgtttat cagctctctg atcacctttc cgtgaccgcc 3285121 gtcacccaca atggccacat ttttcatgag gacacatctc cgcttccggt aaaccgttcc 3285181 gcggtcacat gattggtttg ctgaatccct tctgaaacaa ggacctttcg caccgtcaaa 3285241 cataaaattt tcaaatcgag aaaaaatgac cagttgtcaa cgtaccaaac atctaattca 3285301 aatttctttt cccaggaaat cgcgtttctg ccattgattt gcgcccagcc tgtgataccc 3285361 ggcttcacct catggcgccg tgcctgtttt tctgtataaa gaggcagata gtccatcaaa 3285421 agcggccgcg gcccgacaag gctcagatcg cccttcagga cattcaggag ctgcggaagc 3285481 tcatcaatgc tcagctttct gatcagcctg cccgttttcg tcagccggac ttcatcaggc 3285541 agcagatttc ctttactgtc ccgttcatcc gtcattgtcc ggaacttata tagggtgaac 3285601 ggtttgccgt gcaggcccgg ccttacttgc ttaaagaaga caggtgatcc tattttcagc 3285661 ctgacaacgg cgatggtgaa cagaatgatc acacttgtac agcacaacaa aaaaatggcg 3285721 gccgtcagat caaaaagtcg tttcaggatc aaagattcac agctcctttc gtttttcgaa 3285781 accgttttaa taccagctgt ctttcctctt ttgtacaaac gagcataaaa gcgaaaacag 3285841 cgtagcaaaa gctgactgtc actcccgtcg ctatcaatga cggccagctg tcaatcttca 3285901 caatgaactg aattgcctta cagaccgtcc aggcaaatac agcggctgaa agaggcccga 3285961 ttatgccttt aaggaacacg tgctttttgt agcctgtaat gcgggatacg taaagcggcg 3286021 taaagatggc attttttaaa ataagagaaa tggcccctgc caatgttatg ccgtacagac 3286081 cgagatgagc cggcccgctc agcgtgaccg ccagcaccac attcaccgca cctaacagca 3286141 gggtaacaat cgccggtgtt ttttgttgat taaaagcggt ccatatataa aacagcggca 3286201 taaaggcgag gctgacaacc aagtatccgg catgaataaa taaaagcggt gctatcgttg 3286261 aaaaggacgg tccgagccag attgtcagaa aaggtcccgc caatccgccc aataaggcag 3286321 caggaagtgc aagcaaaaga ccattgagcc ttactgcctt attggcgtaa ttcatcaatc 3286381 cttccatatc gccttttgaa taatatgaag tcatgatggg cgcaaacagg gatgcgaccg 3286441 ttccggccaa gctgcgcaaa agcagcggaa actggataat cgccgcgtat ttcccggatg 3286501 cagacgcccc cagcatcaaa ttggcggtta acagatcaat ctgcaaaaaa agcaggacgc 3286561 cgatttgatt gacggagctc catgcgcccg cttgaaacag ctccttgctt gtacggaatg 3286621 aaagatcctt catacgaaac gaaaaccacg gaatcagctt tttgaagaaa tagaaagaca 3286681 gcacagacgc aataacagca ccagctaaag ctgcaagctg gatctgccag attttcggcg 3286741 caaagcatgc aaacaggagc agcacagaca gcacccgtat aagcatttgc accgcctgaa 3286801 tggaactggt gatataaagg cggttggcat aaaatggtgc agcgccgaag cccgccatca 3286861 gaaacgttaa aataaacagc acactgccga ttaaaatcga caaacgcaca tctgccaaaa 3286921 gcgcttgcgg cacattcatg acgcggtcaa taaaaaaagc cgaacccgca agcggcagca 3286981 agagcagcaa ggaaatcaaa acagaggcgg ctaaataatt gctgatatac gcatttgctt 3287041 tctcccgctc tcccctgtgg gcagcaacag aaaagaaccg aacgacaacc gagctgagcg 3287101 ccacggtaat aaccgaaaag taattaatca cattttgtgt caagtgaaca aagccaaacg 3287161 cttcgacacc gagcgttttg acaataaaag gcgtcatcca aaccgatagg aaaacagaca 3287221 agagaaaagc cgtgagattc gcgctgaaat ttatcgtgaa tttcatgcct gcttcgcact 3287281 gcctttcatt gtcccccgct gctcgaaaaa cagcttgatg agaaaagtga gccgccattt 3287341 acacagtgct aataccaaac gctctcctct taataatttc tcatgctgaa acggtgtatg 3287401 tctgacagcc tgccgcacca tgtcatagga taaaatctgt ctgatcttct ttttgatgtc 3287461 tttcggcgaa ttcggagaag cacaggcatt tgccaaaagc atcggaagct ggtgcctgca 3287521 aatgtacaca ttcaaatctt ctttacatgc gcctgctaag ccgtagtgat tgtagaatgc 3287581 gattttagcc tgatattgtt tttgaagatg ttcatccatc gccggcttat aagggatttc 3287641 tgtcaggctg ttcgggtttt cacgataaat gtacaatcct tcatcaagca ttttcacccg 3287701 ctccgcttcg cgaaaagcgg acaaattaaa gggagagtct tcagcaaaac ggatgtcttc 3287761 atcaaacagc agattcgccc tttcaaaaag ctcacgacgg taaagataac gccatacata 3287821 ccagataaat ctcgtttcgt gagcatgttt aagctgttca gtcatttctg gtttcgtcag 3287881 cacgcggttt gcctcaagct gcggcggcac atatgtccgc ctgtccgatg actgcttgta 3287941 aaaaccgcat ccgacgatgt caagctgatt ttgctccgct tcttcagtca gcctctggaa 3288001 catggcggat gatacataat cgtctccgtc tacaaagccg atgtaagtgc cccgcgcggc 3288061 ctttattccc gtatttcgcg ctgaactaag cccgccgttt gcctgatgaa tgacccggat 3288121 tctcgcatcc cgttttgcat agtcctctgc aatttcgcct gaacgatccg gtgttccgtc 3288181 attcacgagg atgatttcaa tatcagaaag cgtttgacga agcaaagaat caatgcactc 3288241 ttctataaat ggttcaacat tatacatcgg gacaataatg ctgacgagcg ggatcattgc 3288301 gcttcaccgc tgattttgtc acgcagacct ttaaaataca catctctcgg aaagcctgca 3288361 cgggatgttt cttttgttaa aagctcattg actgcggctg ttacgcgctc tggctccgga 3288421 tgttctatca gcttcatgaa cgggatgtct ttaagccatt gatagccctc catcacctta 3288481 tggtcaaagg agcgaatgac aacacacggc gttcctgtca gcgcgcaaaa aatcatgcca 3288541 tgaagcctgt cagtgacgac ggcttctgcg ctttgcagct tagaccacag tgcttcaagt 3288601 tcatgttcgc gtgtatcgcg gctgacccgg cggccgatcg ttgtcgtaaa ggatttgatc 3288661 tcgccgaatt cctcacatag cgcagccttg acccggttcc tctgctcctc ctgaagcacg 3288721 ctttcctgat cctcgcgcaa acacatataa accccttcgc gttctgcggg agccttgctt 3288781 ctgtctaaat acagcaccat gtccggctgc ttcaaaattg ttttttcttg aaaatgctgt 3288841 ttcataaatt gatacgttgt ttcatcccgc gccatcagca ataggccggg gtgcgcatta 3288901 taaattttct gtgcccgttt cagctctttg cgcccttttt tcgtgtcaga aaaatgagcc 3288961 gttgccggaa gctggacaac ccgatagtca tggaatgttt taatgatgaa gcggcgcgtc 3289021 cactcctcat aacggtataa atcccccatg tttccgccgc cgatgataaa gaccatatcc 3289081 tccggatggc gcgagcggat caggcttttt gctgatttgt aaatgtcctt catatcgacc 3289141 tcgacgatgt caaagtccgg gtattcttgc tcaagaaatg ccttgctggc ataagcaatt 3289201 gcgtgatctc ccaaattgtc atgggacggc agcagggtca gtatgatttt tttctgatgt 3289261 gctgcggcct ttaccggttg atctgccgct cccagccaat attgggacgg gtatttgacc 3289321 tttagcagca gccattctgc aaaattgatt ttcaacgatt gtaacgacat gtcctcaccc 3289381 tctgtttctc attttgtact cgatcacccg ctgatacaca gccgatgcca tagcgacgaa 3289441 cggaatcatt ctgtatttcg ccatcagaag caggcatgac cgttttgcgt caaaaggagc 3289501 agtacccgtt tttgaaagac tttcttgaaa caccgggtcc gcgcatatca cgccaacatt 3289561 tctaagcttt tcaaacagcc ggcggctgcc gctcgttttc cattcattca gcatacagat 3289621 gctgctgtga agaacgataa aggtatcaag ctccttgcga tactcctcca gtttgttgtt 3289681 ctcctgtaaa aacgccgcat tcgtctcata cagcgcaagt cctgattcaa acaatttttt 3289741 ctgatagcgc tgcacaatgg aggaaaggtg aattcgataa tgatagagcg gcgtttttac 3289801 gtaggatact gagcgggcga aaaaatgagc cctgaagctg aaaaactgat cctcgacatg 3289861 ctccagctcg cctcggagcg gaaacgacag ccgatgggct tcaatcatgc ttcttctgta 3289921 cagtttgttc catgaaaacc ctctgacctt cccttcgaat aacgccttga tatagtgctc 3289981 cttcggctga tcctgatagg tttgggcaat gtcagagtcc atggttttgc cagtgtcctc 3290041 aaactctgcg gcgtaattgc aaatgaccag atcagtttca tcgcctgctg tccggagcat 3290101 ctgctcgcaa taatcaggct caatccaatc gtctgaatcg ataaacgcga taaattcgcc 3290161 gcgtgcagct tcaatgcctt tattccgaac cgcaccgagt ccctggtttt cctgatgaat 3290221 caccttgaac ctgttgtcca ttttggcgta ttcttctgcg atatccgggc tggcgtcagc 3290281 tgaaccgtca ttgacaatga tgatttcaat attgtccatt gtctggttcc gcagtgattc 3290341 gagacacgtt ctgatatatg tttctgtgtt ataaacagcg actaacagac taaccgcagg 3290401 tgtttccata atgaccggct cctcgtgcat aaattaccgg gaaaaaatcg ttctgtaagg 3290461 cagaaccgat gaatcgaccg gcataagcaa ataactgtaa agaaaataac aaacaacgat 3290521 agcgatatag ataagagcgt tcgatttttc atcaaatatc ctgacgaaat aagggactag 3290581 gatcatttga tacagaccga aataaatatt gaatctggca aaaatcacgt cctttgtggc 3290641 caaaaggccg aacaaaaaac ctagcaggca caaattgacg acaatatcaa tttgcggcca 3290701 cagactccgc agtcgttctt tatagcaaaa tgcaaggaac agcggcagaa ccaaaacagc 3290761 gattttgatc acattcattc catttgtgtt cgtcatgagc catttttcat aatggctgta 3290821 tgagctgttt tcaagtacaa cgacaaacac agaaataaat ttttgatata aaaatgtcat 3290881 gccgagaaat aaagcggata ggccgaatat cgccggtgac caggcttttc ttctgacaat 3290941 aaagtacact ggaatcataa tcagcgccga cgaatgaaag agcgagctga ccagcacaat 3291001 caggaaatat cgcttccagt tcccgctaat gatataacgg atcgcccaaa acaaaacagc 3291061 tgccaccatg tattgcctga tgccgttaaa agatgcgtaa taatgaaagg ttcccaaaaa 3291121 taaaaagaca ctcagctcaa acggcctgcc atagtcggcg agtgtcttca taataaagct 3291181 gtaggtcacg accgccaccg taaaatacat gatttgagga tcttccgtga tgaaattcat 3291241 cagccaaagg agtgcggtaa accccggatc tgtcgctgtt ttcgctgtgc cgaaaccgaa 3291301 tatctgccac acattttgat aatcgcccgc caattcgtac aacagcgtgt acgtctgaaa 3291361 atccgtgccg actcgatagc ggagacctga cacgagcaca agtgaagcga gcggaatcca 3291421 gatcaaaagc ttattcggcc gataccccgt ggcaagcgaa tcatcacggc cgccgcacat 3291481 tttagcgaac caagaccaaa taaatacaat ccccatattg acggcatata caatcatcgg 3291541 ttatggtcct tttccgtgct gatgttgtat acattcagca gcgctcctac attttgctgt 3291601 gcatcgtagc caagttgagc gagtgtttct ttgatgaact cacgcttcgg cctgcctgcg 3291661 gcggccgccc ttgcaatggt ttcagcccag acgctgatcg gctcagaaag acttaatctt 3291721 gtgacaagcc cgagaccggc gtcgactttt tctgtaatgc tgtctgaaat gatgcatgga 3291781 agccccgacg cctgcgcttc cacaagcaca accggcaagc cttcgtacag agacggcatg 3291841 acaaatacat cgaatgttcg catcagttca tggatccgtt cttccgtgcc taaaaagagg 3291901 acgtctgata gcaaattctg ctgccgcgcc tcctcctcta tctccccgca caacggcccg 3291961 tctcccgcca gaacgagctg aaagcgaatg cctctttcct tgagatgtgc ggcaagcttc 3292021 aacaggaacg cgtggttttt cacttcatga aaccgggcca catggccaat gatgagccgg 3292081 tcggctgcaa tgccgcgtgc tgctttttct tcatcagccg cctgcccatt tggggcgaac 3292141 aactcaaggt caatcccgtt aggaagaagg tgaacacgct cccgctccat attggactgt 3292201 ccaaataaaa acctgcccgc atcctctccg caggcacaca gcgctgtcgc atttgccaaa 3292261 atgagccgcc tgaacacgag cagctgcaat cgatccttcc agttgaagcc ggtcttccaa 3292321 gacgtattgt gggagtggca taccctgacc ggcactccgg cgagccttgc cgcaagggcg 3292381 ataaaacccg tttggaaatc cgtgtgcgca tgaacggcgc tgaacggccc attttctttt 3292441 atcgcgtttc tcacattcct cacaaatgta aggggattgc tttgcccaat gctcgggaca 3292501 taaaaaagcc gcccgcctaa agataaaatc tcttcatcat aagcgcacgg atcatttcga 3292561 tacgttaaaa aatcaaattg cactttgctt ttgtccatct tccgatataa attcattacc 3292621 atggtttccg cgccgcccct gttcatgccg ctgagaacat ggagcacgcg cttttggctg 3292681 ctattcatgc ttgacaagcc cttccttttg gttcatcact ctttttttat ggtagcgatt 3292741 catcacagct gcaggcataa aggcgcgaat taacggtttt gcgatatata tgtaatcaga 3292801 taaaggaagc ttcaagcgtc tgcacgcctg atagacaaga atggcattgt cgattgaata 3292861 cgtaaatgac cgccgtttga atgcatcgct gtcttccctc actttataca aggcttcctg 3292921 aagattatag cccctgaagc cctcttcaaa aaagcgaagc cacaaatcaa tatcttccat 3292981 tcgtctcgtc cgccgcaccg accggtagcc tttcagcgtg cggtaggcac tcgctctcat 3293041 cataatcgtg ccgtggcaaa atggagtccc ttttgccatg atgcccggct ccggaacaga 3293101 aggcagaatg cgggcgcctc ttacgccaaa ttcatcaaac acaagcatgc cggtgccaac 3293161 cacctgatag tgtcggtgct tttctaaaaa cgcgacctgc ttttccagac ggcgcggaaa 3293221 cgaaaggtca tctccgtcct gacgtgcgat ataatcgcct gtcgcatgcg aaagacaatg 3293281 atttaatgat gcggcaagcc gcttatttgt tttgttttga atcagtttga tgcggtcgct 3293341 gtaatgagcg gcatactgct tcgcgatacg gagcgtgccg tctgttgacg catcatcgca 3293401 caaaatcagc tcccaatttt tataggattg gctgagtatg gattctatgc tttctgccaa 3293461 agtgcgttcg caattataaa tgcccataat gacagaaact ttcggtcctg agttcatacg 3293521 cttttctcct ttgtatccat atccatgtac gcggaataaa tatctgccat ttcttccacc 3293581 gttcgcgcct ccgagaagcg caaggctgtt tttcggcctt cctgtcccag ctttcggcag 3293641 agctccggct tatggtaaag ctgttcaatc cggcgggcaa aagcagcact gtcaccgatt 3293701 ttgatcagaa aaccgttttc tccgtcgcgg atgatttccc gatgcccgcg attatctgtg 3293761 gcgatcgccg gttgttctgc cgccattccc tcaagcacat tcataccgag gccttctcta 3293821 atgctggatg cgacagatac atccgcaagc tgaatcaact catgtatgtc gctgcaaaag 3293881 ccgtaaaaac agacatgggc ggaggcacca agcttttcag ctaacgtttg atacgtatgt 3293941 tccattgccc cttccccggc aaacacaagg cggagtgagg gaattttttc ttttagcaag 3294001 gctgcggctt caattaactg cttctggttt ttgttcagat tgagctcagc cggataaacc 3294061 aatataaaat catcttcacg gaacccgtgc ttttctctga gtctttgctg ctctatcgga 3294121 ctgacaggcc ggaaacgctc ggtattgacg ccaatgccgt gaattttctg cgtccttccg 3294181 cccggccttt gaagtccttt cgcccgtatg taatcctctt cattaatcgt aatcaggcag 3294241 tctgtatatg ctgaaagcca tttctcaacc ggatagtaaa gaagccaatt tttcatcggt 3294301 gcccctttgc agaagtgaaa tccgtgcgct gtgtacagca cctttgttcc gtgccgccgt 3294361 gcctgcctcg ccgccagtct ggcgagaacg ccgccgaccg gtgtatggca atggacaatg 3294421 tcgtattcat aagtgtcaat cactttcttc agctgcctat aaacggccag gttctgaggg 3294481 tcaaaaggtg acctgcgaat cgggatggag aatttctcat ccacatacgg cagcttggtt 3294541 tgtccgttcg cggcgacatg aacctcccag cccatttgct tgaaccattt aaaataaggg 3294601 aggtgaaagg ccttaaaatg ataatcaaca gtcgcgcaaa acaatatctt tttcgtcatt 3294661 ttcactcccc ctaatgaacg ctggcagccg tcatttcttc tgatgtattg attgccgcaa 3294721 acagcctcgc tctcaggtcg gcttccggca gctcatgaaa atcctcgata aagcgcatca 3294781 gcaccggcca atcgccgtcc accgctttac cgatgtgaat ttttggaaag atttgttcag 3294841 catggacttc atttttgttc agcaattctt catacatttt ttcgcccgga cgaatgcctg 3294901 tgaattcgat tggaacctgc tcagtcgtgt agccggacaa atgaatgagg tttttggcaa 3294961 gatccacaat ctttacgggc tctcccatat cgagaacgaa aatttgacgc cctttcgcca 3295021 gtgccccagc ctgaatcaca agccttgatg cctcgggaat cgtcatgaaa tagcgggtca 3295081 ttgccggatg tgttactgtc accgggccgc ctttttcaat ctgttttttg aaaattggaa 3295141 tgacgctgcc gcggctcccg agtacattgc cgaagcgaac agcaacaaat ttggttctgc 3295201 tgactttccc aagattcata ataatcatct ctgcgaatcg ttttgtcgcc cccattacgt 3295261 tggctgggtt caccgctttg tccgatgaaa tcagcacgaa tgtctcagtt cccgacatat 3295321 cggctgcttc cgcgacattt tttgttccga taatattgtt tttgaccgcc tcttctggat 3295381 tgtgttccat taaaggcaca tgcttatggg cagctgcatg atagacaaca tgcggctcgt 3295441 attttttcat caaggtaaac attttatcgc ggtcctgcac atcagcgatt tccgtatgga 3295501 acacaatgtg tttgccgaat cgtccgttca gctctgtata aatcgaatga atgctgtttt 3295561 ccccatggcc gagcagaatg atttccttag gctgaaacgc gctgatctga cggcagattt 3295621 ccgagccgat tgatccgccc gctcccgtga cgagaactgt ttttcctttg atgcggttcg 3295681 aaatttcgct agtgtcgagg gttaccggct ttctgccgag caagtcctca gcttttacat 3295741 ctctgatttg tccggcagtt cgtgtgccaa gcagcatttc atcaaaatga ggcataattt 3295801 taatgcttac tccggttcgc acacattctt tatataacac ctgaagctca tgggtgcgga 3295861 gtgaaggaat ggcaataata atataattaa ttttgagctt ttgcaccgca ggcatgatac 3295921 tttcttttcc gccgattacg ggcagcccca taatttctaa tttatgcttc gtttggtcgt 3295981 catcaataaa agcgacaggt atgatatcag gttcatcttt cgaaagcagc tgcctgacca 3296041 tcagagtccc acctgagccc gccccgataa tcagcgcgcg ggacgaggcg cagcgttttt 3296101 tcctgatgct ttcgtttaat actctggata aaatacgggt ccctccaata gacaaaagct 3296161 gaagcaccca gcacgcggtt aacagacgga agaacatcgt gtgatacaca gcatactgaa 3296221 tgacgccggt cacagcggct gaaagcgtaa tgcccttaag caggacaatc agctcgccaa 3296281 gcccggtgta tgtccacacc tgtttatact gattgaacag gaaagcacac acatgatagc 3296341 tgaggagcaa gctgacagcg gtaagcagta atgctccgga gtcataaaat tgataggaat 3296401 cttttaaaaa ttgatatcct gcaataactg aatttaaaac gaggtaagta tccagcgcaa 3296461 taatcattga cagtcttctc cggtaactca accttttccc ccctaattct tttatcggtt 3296521 tagctgcggc ggttttcgtc tctccaaaaa atcggcagca gctaaaccga caatacgtcc 3296581 tatgtatata tgagataagt gggcatttaa cccatcctca cgccccgcca gcgacgacca 3296641 gcatctaagg cagcaacttc agctgcccac agcagagccg agtgcctcca ttgatacagg 3296701 tcaggagaca tcacctttac aaaaactagt aggaatagtg ttccgatttt ttcattttct 3296761 ttttgtttaa aagagcgcct aacagcttcg cattggattg ttccagtgca tcttttgctt 3296821 tcagaacggt atcggttttt gtttttccgc ttaaaacgac gagcacgctg ccgtctgtct 3296881 gatttgctag aatctgagca tctgcaacag ccaaaagagg aggggaatca aagatgacga 3296941 ggctgaattg ttcatagatc tcagatatta aatctcccat tgcttttgaa gacaacagtt 3297001 ctgccgggtt tggcggggtc ggcccgcttg tcagtacata taagttatcg atcggcgtct 3297061 tttgcaccgt ctcactgagt gaagcattgc cgaccagcac atttgtcagc ccggttacat 3297121 tatcaacctg aaacgtctga ttgatggtcg gctttcttaa atcggcatcc accagcagta 3297181 ctttcttttc ctgctgctgc gcaaagacag ccgcaagatt cgctgcactg aacgatttac 3297241 cttcaccagg cacagaggag gtgacgagga tagatcgcaa gttggtctgg acagatgaga 3297301 actcaatgtt tgtccgaatg gtgcgatatt gttccgcaac aactgattta ttgtgtaaaa 3297361 cagatatttg agccaaacct cgccttgctt tcttttttct aaagatcact cgcttcactc 3297421 cccgaaatgt tttatcccgc gattccgccc tttgtggaca tcaggaacgg agcctaagca 3297481 tggcaatccg gttctctcgc tgagctgccg tgcgcttttg catgtatcat cgagaaaatg 3297541 cagaaaaaat gccagtgtaa tgccgcccat gacagcagcg ccaaaagcca tgaccatatt 3297601 tcgcagcctg gccggcttga tcatcgggct ttccgaagcc ttcgcctctg ataatatatg 3297661 tacgccttgt acattcattc tttcatctac ttctttttca aacttgttca ctaacgtgtt 3297721 cgcaatctca gctgctttcg ccggatcgtg atcctgaacg gcaacgttga ttatttctga 3297781 ttcattttca ctgctggtaa ccacttttcc tttcagcgag gaagccgatt cagataggtg 3297841 caattccgcc ttaacttctt ccatcaaggc agtgcttttc ataatcgatt ggaacgtgct 3297901 gctatactga agatttcgct ggatgtcact gagattcgag ttttcttcac cgtctgattc 3297961 atgaaccagc acctgtgtcg acgcctggta ggtcggtgaa atgaccttaa attgcacaaa 3298021 acccataata agggtgacgc cgattgtgat gagcagaatc agcacgaatc tgtgtctgac 3298081 aatcgcatat aattctttga aactcatatt ctcattcatg tattcatagc cttcagcctt 3298141 cccgcggctg gcttcccgcg cccctttctg ttaatgattg gattataaaa gaaaacgtta 3298201 ttatttaaaa attgcaaaat aagccaataa gttctcttta gagaacaaaa tcatgatttt 3298261 cctctaattt actgcacttc ccttattatt ttaaatttta taaagaacga aaaattcctt 3298321 ataatgaacg aaataacgac aggaatagag gagaatttca tattatgatt ggaagaatta 3298381 tccgtttgta ccgtaaaaga aaaggctatt ctattaatca gctggctgtt gagtcaggcg 3298441 tatccaaatc ctatttaagc aagattgaaa gaggcgttca cacgaatccg tccgttcaat 3298501 ttttaaaaaa agtttctgcc acactggaag ttgaattaac agaattattt gacgcagaaa 3298561 caatgatgta tgaaaaaatc agcggcggtg aagaagaatg gcgcgtacat ttagtgcaag 3298621 ccgtacaagc cgggatggaa aaggaagaat tgttcacttt tacgaacaga ctcaagaaag 3298681 aacagcctga aactgcctct taccgcaacc gcaaactgac ggaatccaat atagaagaat 3298741 ggaaagcgct gatggcggag gcaagagaaa tcggcttgtc tgtccatgaa gtcaaatcct 3298801 ttttaaaaac aaagggaaga tgatgatcgg ttaaagggct aacgttcgca tctatagggg 3298861 aaatctgttt ataatggggg aaaaagggag agaacacaat gactcatcaa atagtaacga 3298921 ctcaatacgg caaagtaaaa ggcacaacgg aaaacggcgt acataagtgg aaaggcatcc 3298981 cctatgccaa gccgcctgtc ggacaatggc gttttaaagc acctgagccg cctgaagtgt 3299041 gggaagatgt gcttgatgcc acagcgtacg gctctatttg cccgcagccg tctgatttgc 3299101 tgtcactttc gtatactgag ctgccccgcc agtccgagga ttgcttgtat gtcaatgtat 3299161 ttgcgcctga caccccaagt aaaaatcttc ctgtcatggt gtggattcac ggaggcgctt 3299221 tttatctagg agcgggcagt gagccattgt atgacggatc aaaacttgcg gcacagggag 3299281 aagtcattgt cgttacattg aactatcggc tggggccgtt tggctttttg cacttgtctt 3299341 catttaatga ggcgtattct gataaccttg ggcttttaga ccaagccgcc gcgctgaaat 3299401 gggtgcgaga gaatatttca gcgtttggcg gtgatcccga taacgtaaca gtatttggag 3299461 aatccgccgg cgggatgagc attgccgcgc tgcttgctat gcctgcggca aaaggcctgt 3299521 tccagaaagc aatcatggaa agcggcgctt ctcgaacgat gacgaaagaa caagcggcga 3299581 gcacctcggc agccttttta caggtccttg ggattaacga gggccaactg gataaattgc 3299641 atacggtttc tgcggaagat ttgctaaaag cggctgatca gcttcggatt gcagaaaaag 3299701 aaaatatctt tcagctgttc ttccagcccg cccttgatcc gaaaacgctg cctgaagaac 3299761 cagaaaaagc gatcgcagaa ggggctgctt ccggtattcc gctattaatt ggaacaaccc 3299821 gtgatgaagg atatttattt ttcaccccgg attcagacgt tcattctcag gaaacgcttg 3299881 atgcagcgct cgagtattta ctagggaagc cgctggcaga gaaagttgcc gatttgtatc 3299941 cgcgttctct ggaaagccaa attcatatga tgactgattt attattttgg cgccctgccg 3300001 tcgcctatgc atccgcacag tctcattacg cccctgtctg gatgtacagg ttcgattggc 3300061 acccgaagaa gccgccgtac aataaagcgt ttcacgcatt agagcttcct tttgtctttg 3300121 gaaatctgga cggattggaa cgaatggcaa aagcggagat tacggatgag gtgaaacagc 3300181 tttctcacac gatacaatca gcgtggatca cgttcgccaa aacaggaaac ccaagcaccg 3300241 aagctgtgaa ttggcctgcg tatcatgaag aaacgagaga gacgctgatt ttagactcag 3300301 agattacgat cgaaaacgat cccgaatctg aaaaaaggca gaagctattc ccttcaaaag 3300361 gagaataaat atggggaaaa caggatacat tggtgctgcc attgttgtgg cagcttgtat 3300421 cattattttg tcggccgtgg tatgtttacg ggacacagtc tattaccagc ctatgcgctg 3300481 gactggcatc atactgtttt tcgcgggaat tgtgatggtt cccgcatact cagcaaaaag 3300541 aaaacccgga aaagagaagt aattctcttt tccgggtttt tatgtttatt ataatcttcc 3300601 cgcgcgaata tcgtctgtca ttccctcata aggagccttc gaaatcactt cttcgttgtc 3300661 gactccttca tttttcagaa atgtaatttc cgcaaattca ggtacaacgt attttggata 3300721 cgtttcatat ttttcgcggg attctttcat caaatcaatg tggtcatttt ggtagcaaac 3300781 cgtaatttca ggatgttcat gcacccattt cgggaagaaa ataatgccat gcatgcgttt 3300841 ttcatttggc ataaagttta atgaaacatc cgtgccagtc ggctctgtcc aagacacttt 3300901 atatacgcct tctgtcagtt tgacaatatt cacttcctga tctcgaaccc agcgtccggc 3300961 aaccattccg ctatgaattc tataatcaat tgtatggtcg tttttaatat aaatctcgta 3301021 ttcccatccg ttttcatacg tataaatcat gtggcttccg ataaagtttt ccatcttaca 3301081 cactctcctt agtcttttac tgtacttcat aaatgtctag tagaacgtaa tcaggggttc 3301141 tttctgcgga accgataaac aagcggtcat ggagccattg atagacttca ctgcctgttt 3301201 caaacgtcgg taccgtacga aaataaacat gctccggttc aataatttcc ccggctgccg 3301261 cttgttttcg aaacggcttg ctgacttgcc gtattccatt gttttcaatg taaatcagtt 3301321 catgatctgc tgtttcaatc acatacctgg cagataaatc tgttctgccg ttagcgcgaa 3301381 tcatttgtga atcggcaccg cccggcaaaa tacgtccctt tacttccccg gttattgttc 3301441 ccgaacgaat cggaatgaat catctcagtc ccaggcttgt ctcaccaatc gtgataggcg 3301501 gatcaacctt gatttctaaa gaggcgaatg gttttaaaac cggcttcttc acgagaacca 3301561 cctcaccttc agaaaaaatc atgtaactat ttacatgttc actttaacac cattgcagtt 3301621 aactgtcaaa caataggaac ataaaaaaac aaggactgtt tgaagacagt ccttgtctga 3301681 agctagcttt gataagcaag atatgtgctg acagtgcttt tggcaagaca ggcagaggaa 3301741 tctataatcg gaatctcact ttgaatatga tctaacaccg catttaaatc cgtgcaggct 3301801 gaaatgatga tgtctgcatg ctgactgatt tcttcatata gcgtctgcca caatgcttgt 3301861 gtatgctgca tatgatttgg ctgtttgatt gcggcgataa gctggttcac agcctgctgc 3301921 caatggtcct tgtgaataac ttcttgtcca tttcccttca gaactttttg gtagatggcg 3301981 gattggatgg ttggctctgt tcctaaaacc accgcttttt ttgcgggatg cggaatctct 3302041 tttatcgttt cctcaacaat atgcaacata ggaactgaca atgcctgctg aatctcttca 3302101 tagtagacat gcgccgtatt acaaggcagc gcaatgaaat ccacgcctgt tttctcgagc 3302161 tttaccgctc cgtcgataat cgcttttttc atctcgtcat ggtcaattgg acgatctgca 3302221 tagaagggcg tcgggcatga atagatcatc atgtgcggat agtcaatatc gtttgaagcc 3302281 ccatacagct tctgacagta atcaatcacc ttatcaataa acggcgaggt cgatttcggc 3302341 cccattccgg ctaatattcc gatcatcaaa ttcattcctt tctacttcgt acggaccgct 3302401 tcttcctctg agccatcctc atagaggata aagcttttcg cagcatcctc acctaatgta 3302461 aactcgactt caacagacaa tgctcgcaga aagaaacggg tttccgagga aggaaataac 3302521 tccagtctca gctgtccggc gatctccaaa taaagccgtt cattctcggt tgtcacctgt 3302581 gcagccgtcc catcctgcaa caggtagctg ccaacatagc ggctgtatat cgccgtatca 3302641 attgcttttt tctttttatc agcaggacgt tccgggacat catatggctg gccaaataga 3302701 atatgttccg ccgccttcag aatcgcttgt tcatattcag tatcctcttc cttattactc 3302761 aaatagatca gcgttttacg atgatcgata tatcggatca tcatcgtcga atagccgggc 3302821 catcctccgc tgtggctgac aatccgccct ttttcaggac tgttttgcag cacccagcca 3302881 aagccataat caattgtttc tccattgttg aggcgcactg gagaaaacgc agattcctta 3302941 gaagccttgc tgatgaaatc gtcctgatat aaagcctgat caaatcgaaa caaatcgctt 3303001 gtgacagagt taaccgtccc atctccctgt atgccatcga gatacacaac atagttcgtt 3303061 tcctccagct catcagggag gacgtatgtt tcggaatgta catcatacac atatccatat 3303121 gcataatgat caattcgctc aggcgaaagc ctcctgttat acactcttgt ttcattcatg 3303181 cctgccggta aaaaaatact tgtttttata aaatccgcat agctcatgcc agatgctttt 3303241 tcaatgataa ccgccagcag cacatacccc gtattgctgt acatccagcc ttcattcggt 3303301 tcaaaataac cagatagccc ctcattcatc agcatatcga caatatcctg attcaccgca 3303361 atcttgtgtg aatcccaatt ggcaaaaaac catcccatat aatcaggaag ccctgacgta 3303421 tggttcaata aatgccgaat cgttacgccc tgatacggaa aaccgggcag ccagcgatcc 3303481 actttatcct catagccaag aatccccttc tcctccagca agatgattcc caatgctgta 3303541 aaaggctttg acaaagacgc taactcaaac aaagagttgg ttttcaacgg gcgtttttcc 3303601 gtcatttccg catagccaaa agagtggtga tataaaatat cgccaccctc cgcagccaga 3303661 accgtcccgt taaactgatg tttttcgcct aatgtctcaa ataacgtctg aagatgcttt 3303721 cttttattct gcttcattcc tccacctccc atatctctgt acgttactaa cctactaacg 3303781 tttcaaatat tttgaaaaat ccttcagtta gagatccttt ttaacccatc acatatacct 3303841 gccgttcact attatttagt gaaatgagat attatgatat tttctgaatt gtgattaaaa 3303901 aggcaacttt atgcccatgc aacagaaact ataaaaaata cagagaatga aaagaaacag 3303961 atagattttt tagttcttta ggcccgtagt ctgcaaatcc ttttatgatt ttctatcaaa 3304021 caaaagagga aaatagacca gttgcaatcc aaacgagagt ctaatagaat gaggtcgaaa 3304081 agtaaatcgc gcgggtttgt tactgataaa gcaggcaaga cctaaaatgt gtaaagggca 3304141 aagtgtatac tttggcgtca ccccttacat attttaggtc tttttttatt gtgcgtaact 3304201 aacttgccat cttcaaacag gagggctgga agaagcagac cgctaacaca gtacataaaa 3304261 aaggagacat gaacgatgaa catcaaaaag tttgcaaaac aagcaacagt attaaccttt 3304321 actaccgcac tgctggcagg aggcgcaact caagcgtttg cgaaagaaac gaaccaaaag 3304381 ccatataagg aaacatacgg catttcccat attacacgcc atgatatgct gcaaatccct 3304441 gaacagcaaa aaaatgaaaa atatcaagtt cctgaattcg attcgtccac aattaaaaat 3304501 atctcttctg caaaaggcct ggacgtttgg gacagctggc cattacaaaa cgctgacggc 3304561 actgtcgcaa actatcacgg ctaccacatc gtctttgcat tagccggaga tcctaaaaat 3304621 gcggatgaca catcgattta catgttctat caaaaagtcg gcgaaacttc tattgacagc 3304681 tggaaaaacg ctggccgcgt ctttaaagac agcgacaaat tcgatgcaaa tgattctatc 3304741 ctaaaagacc aaacacaaga atggtcaggt tcagccacat ttacatctga cggaaaaatc 3304801 cgtttattct acactgattt ctccggtaaa cattacggca aacaaacact gacaactgca 3304861 caagttaacg tatcagcatc agacagctct ttgaacatca acggtgtaga ggattataaa 3304921 tcaatctttg acggtgacgg aaaaacgtat caaaatgtac agcagttcat cgatgaaggc 3304981 aactacagct caggcgacaa ccatacgctg agagatcctc actacgtaga agataaaggc 3305041 cacaaatact tagtatttga agcaaacact ggaactgaag atggctacca aggcgaagaa 3305101 tctttattta acaaagcata ctatggcaaa agcacatcat tcttccgtca agaaagtcaa 3305161 aaacttctgc aaagcgataa aaaacgcacg gctgagttag caaacggcgc tctcggtatg 3305221 attgagctaa acgatgatta cacactgaaa aaagtgatga aaccgctgat tgcatctaac 3305281 acagtaacag atgaaattga acgcgcgaac gtctttaaaa tgaacggcaa atggtacctg 3305341 ttcactgact cccgcggatc aaaaatgacg attgacggca ttacgtctaa cgatatttac 3305401 atgcttggtt atgtttctaa ttctttaact ggcccataca agccgctgaa caaaactggc 3305461 cttgtgttaa aaatggatct tgatcctaac gatgtaacct ttacttactc acacttcgct 3305521 gtacctcaag cgaaaggaaa caatgtcgtg attacaagct atatgacaaa cagaggattc 3305581 tacgcagaca aacaatcaac gtttgcgcca agcttcctgc tgaacatcaa aggcaagaaa 3305641 acatctgttg tcaaagacag catccttgaa caaggacaat taacagttaa caaataaaaa 3305701 cgcaaaagaa aatgccgata tcctattggc attttctttt atttcttatc aacataaagg 3305761 tgaatcccat atgaactata taaaagcagg caaatggcta accgtattcc taaccttttt 3305821 aggaatattg ctgtttatcg acttatttcc aaaagaagaa catgaccaaa aaacaaaatc 3305881 aaaacagaag ccggactacc gggcggcata tcattttacg acgccggata aatggaaaaa 3305941 tgaccctcaa aaaccgatct attttgatgg caagtatcat tatttctatc tatataaccg 3306001 ggattaccca aaaggcaacg gcacagaatg gcgccatgcc gtctcagagg atttggtgca 3306061 ctggaccgat gaaggcgtgg cgattccgaa atatacaaac ccggacggtg atatttggac 3306121 cggttccgtc gtggtggata aagagaacac agccggcttc gggaaaaatg cgcttgtcgc 3306181 gattgtgaca cagccctcag ccaaagacaa aaaacaggaa caatatttgt ggtacagcac 3306241 agataaggga aaatcattca aattctacag tggcaacccc gttatgccta atccgggcac 3306301 agacgatttc agagatccga aagtcatatg ggatgaccaa gataacaaat gggtcatggt 3306361 catggctgaa ggatcaaaaa tcggctttta tgaatccgat aatcttaagg actggcatta 3306421 cacaagcgga ttcttcccag aacaggcggg aatggtggaa tgtcccgacc tctacatgat 3306481 gcgggcaagc gacggaacga ataagtgggt tctcggtgcc agcgcgaatg gcaaaccgtg 3306541 gggcaaacca aatacgtacg cctactggac cggaagcttc gacggaaaag aattcaaagc 3306601 ggatcagact gaagcccaat ggcttgacta tggcttcgac tggtatggcg gtgtgacgtt 3306661 cgaagacagc aaaagcacag atccattaga aaagcggtat gcgcttgcct ggatgaacaa 3306721 ttgggattat gccaacaaca ccccgacaat gaagaacggc tttaacggca cagattctgt 3306781 catacgcgaa ctccggctga aggagcagga tggaacatac agcctcgtct cacagccgat 3306841 tgaagctttg gagcagctga ctgtttcaac tgacgaaata gaggatcagg atgtgaacgg 3306901 atcaaaaaca ttgtcgataa caggtgatac gtaccagctt gatacggatc tttcttggtc 3306961 agagctaaag aatgcaggcg tcaggctcag agaatcagaa gaccaaaaac gccatattga 3307021 tgtcggcatt ttcgctgaag gcggctatgc ttatgtcaat agagcagcca caaatcagcc 3307081 tgacaaaagc aatacctatg tcgaaagcaa agctccttat gatgtaaaca aacgtaaggt 3307141 gcatttgaaa atacttgtcg ataaaacaac gatagaagta tttgttggcg acgggaaaac 3307201 cgttttttca aatgaagtct tcccaaagcc tgaagataaa ggaattaccc tttattctga 3307261 cggcggcaca gcctccttca aaaatataac agtgaaacac tttgattcga ttcatgaata 3307321 aaaacagggg cggcgcaggc tgcccctgtt tttttattag gagcggtatt ctctgttaca 3307381 tattgggcat tgtaaggaat ataaggctgg tttcaaagga ggaagcgaat gtctaaacaa 3307441 ggaaattttc aaaaatcaat gtcgctgttt gatctgattt tgattgggat gggagccatc 3307501 tttggatcag cgtggctgtt cgctgtcagt aatgtcgctt caaaagcagg gccctccggc 3307561 gctttttcct ggatcctcgg aggagccatt attttgttaa tcgggcttgt atatgcggag 3307621 ctcggagccg ctctgccccg taccggaggc atcattcgat accccgttta ttcacatggc 3307681 caccttgtcg gctacttaat ttcgtttgtc acgattgtcg cttatacaag cttgatttca 3307741 attgaagtga cagctgtgcg ccagtatgtg gcctattggt ttcccggcct gaccattaaa 3307801 gggtctgatt cgcctaccat ttccggctgg atcttgcagt ttgccctatt atgcttgttt 3307861 ttcctgctga attattggag cgtcaaaacc ttcgctaagg cgaatttcat catatcgatt 3307921 tttaaatata ttgtgccgat taccatcatt attgtgctga tctttcattt tcagccggag 3307981 aatttatccg ttcaaggatt tgcaccgttt ggatttacag gtattcaggc tgccatctcg 3308041 acaggcggcg tcatgtttgc gtatctcggc ctgcatccga ttgtatctgt agcaggtgaa 3308101 gtccaaaatc caaaacgcaa tatcccgatc gctttaatca tttgcatcat cgtttcaacc 3308161 atcatttata ctgttttgca ggtcaccttt attggtgcaa tcccgacaga aacactgaaa 3308221 catggctggc cggcaattgg ccgggagttc tcattgccgt ttaaggatat tgcggtcatg 3308281 ctcgggttag gctggcttgc aacgcttgtc attttagacg ccattctgtc tcccggagga 3308341 aacgggaata tctttatgaa tacgacatcc cgccttgttt acgcctgggc gcgtaacggc 3308401 acattatttg gcatattctc aaaggtcaat aaagatacgg ggacaccccg cgcttcgctt 3308461 tggctttcgt ttgccctgtc cattttctgg acacttccct ttccttcgtg gaacgcgctc 3308521 gtcaatgtct gttcagtcgc gctcattctt tcatatgcga ttgcacccat ttcttcagct 3308581 gcgctgaggg tcaacgcgaa ggacttaaac aggccgtttt atttaaaggg aatgagcatt 3308641 atcgggccgc tttcctttat atttacagcg tttatcgtgt actggtcagg atggaaaaca 3308701 gtctcctggc tgctcggttc acaactcgtg atgtttttga tctatctctg tttcagcaaa 3308761 tatacgccta aagaagatgt cagccttgct cagcagctga aatcagcctg gtggcttatc 3308821 gggttttata ttatgatgct gatcttttcc tacatcggtt ctttcggaca tggtttaggg 3308881 attatcagca atcccgtcga cctcatttta gtcgcgatcg gctcacttgc gatttattac 3308941 tgggcaaagt ataccgggct cccaaaagcc gccattgatt atgataaata aagaagcaag 3309001 aggttttctt gcttctttat tctttacaaa caaacataca cgcgataaaa tgaatgagag 3309061 tcagtcatta ctggaggtgt tcctcatgcc aaaacaaaca tcgggtaaat acgaaaaaat 3309121 attgcaggcg gccatagaag tcatttctga aaaaggcctc gacaaagctt ctatttctga 3309181 tattgtcaaa aaggccggca ctgcccaagg aacattctat ttgtattttt catctaaaaa 3309241 tgccctcata ccggccattg cagaaaatct cctcacccat acacttgatc aaatcaaagg 3309301 taggctccat ggggacgagg atttttggac cgttttagat atattaattg atgagacatt 3309361 tctcattaca gaacgccata aggatattat tgtcctctgt tattccgggc ttgcgatcga 3309421 ccactccatg gaaaaatggg agacgatcta tcagccttat tattcctggc ttgaaaaaat 3309481 catcaacaag gccattgcaa accatgaggt aacggaagga atcaattcaa aatggacggc 3309541 cagaacgatt atcaacttgg tcgagaatac tgcggaacga ttctatatcg gatttgaaca 3309601 agatgaaaat gttgaagtgt ataaaaagga aattttcact ttcttaaaac ggagcttagg 3309661 tactgcttaa aaaatgactg ggtaacaccg ctcatttttt aatgccctaa aaatgactga 3309721 cgttcattca taaaatagag aggtgtttca tttgaattgg gttcttgttt ttattgcagg 3309781 gcttttagag gttgtttggg cctcttccct caaacatgcc gattcgcttt tggattggat 3309841 catcattttt atcttaatcg cggtcagctt tatcctgttg atccgctctt atcaaaaaat 3309901 cccgatggcc gcggcgtaca ctgtgtttgt gggaatcgga accgtcggaa catatctgac 3309961 tggaattgtt ctgggcgaat ccttctcagc agcccaaatg ttctttttag ctttattgct 3310021 ggctggcatt ttaggaatga aattatttac gaaagaaagc aaatctcagc cgggaggtga 3310081 aaaataatgg catggttttt attagtgatt gccggcatag aagaaattat agctgccatt 3310141 gccatgaaat atatagacgg aacaagaaaa aaatggccga tcattgtgat gactgttgga 3310201 ttcggcttat ccttttactg cctgtcccaa gcgatgatcg tcctgcctgc cggagtcgca 3310261 tatgccgtct ggactggcat tggaagcatt ggtgtttcgg cggtcgggct catctggttt 3310321 aaggagcggt ttcagctttc acaggtgatt tcactttgcc ttatcctagc cggcgtcatc 3310381 ggcctgcgtc ttacgtcatc ttcataaaat caaggcatat acagctgtat atgcctttgc 3310441 cattaagctt cgtgatgttt ttgaagatga agcggcggcg ggatgagcca gcctttgttt 3310501 tttagcagcc ttaagtattt tgcgccggtt gccgctttcg acatatgaaa ttgcccaaac 3310561 atcatggcaa tatcctcacg aatcgattgc cccatcattt tgctgcatgt cacaagacct 3310621 gcagcatttt ctgctgccgc ggaagccgcc acatccggat cgagaaaccg tgcaccaggc 3310681 ggaatatcgt taagatctgc tgtcggcggt tcaggagaag ccggcggcag cgccaccccg 3310741 ttttctttca ggatcgtgct gacctgtttg atttcatctt ggcatttctc aatagactca 3310801 cgaagcagct tcttcaggtc gtcatcaccg acatgattca atagcatttg gtaattgccg 3310861 accattttat tgcccgccat cacataactc cacaagccga atacctcacc gtaatgcatc 3310921 ggttcatcct gcggatttcc gcttaaaata cccatgctca ttctcctccc atattcaata 3310981 ttgcacattt cataacgtgc ccaagcggag gaacatttat gtttcagcgg aaaagattta 3311041 tgaaatgaaa caaaacaaaa aagacaagag tggcaagttg ccaaaccatt gtctttcctg 3311101 ttgtttgatt ggacgcactg aagggattcg caccccgaca gacaagatac cggaaaccat 3311161 tcaagtgctt tttagtatga gtcattgatt ctgtctttaa taaactttaa cgagatggcg 3311221 ggatgctttg cggaaaacga aatacatttt cggggtcata tttcgccttt atttctcgaa 3311281 gccgcgcaaa gtttgcgcca taatattctt ttccgaagtt ttcaatgttt tgatctggaa 3311341 cattaacata tgaacctgct acatatggtt gcatcagctg acgcactctt tcaactgatg 3311401 caagatttga atcttcttgt gatttatttt tccaactagc cgtccattcc gtataaaata 3311461 atggatggcg ccaaaaaaag gcagtttcgt ctttagggac tctgcttata gcaccacccc 3311521 aattgataaa aaagaaattg gcttctgttc cagtagcatc ttccaaaaat tttctcatga 3311581 ttgaaatggg ttcgtcagac caaaaatcat gaccccatgc cgaggagaat ttaacactct 3311641 gatcatttct gccagggatg ggttcgtcag ggtctaagaa atctatagca tctggatagt 3311701 ataatgtttt gatatctgct tctgttggag ttcccgcatg taataaaggt tttaataatc 3311761 gaatcaattc agttttcgaa ccgaggaaaa ttccttctgc atgacacaaa ccatttattt 3311821 tgctgtaaat ttcaaggtag catcctaatc gttcatctac aaacggagcc catttctgcc 3311881 aagctttaaa taccgtttct aattgttccc acggccagat aatattgaag acggttgcag 3311941 ttttaggggc acgatgaact ttgaatgtat attgggtatt atatccaaag ttacctcctc 3312001 ctccgcctct agaagcccat agcaaatcct cattgtgaga ttgatctgcg tgaataatcc 3312061 ttccttttgc atctaccgtt ttcagcgcga gaaggttatc acttataagg ccaatcgatc 3312121 gtgagagtac accaaatccg ccgcccatcg taattccccc gattccaact gttgggctat 3312181 ctccaaacgg agccataaaa ccgtctcgag ctaatccctt tacaagcggg ccaacgggaa 3312241 taccagtttg aacggttgca atagcgtttt cttcatctaa gaaaacttta ttcatgtcac 3312301 tcacatcaat aacaattcct ccacttacta ctgaaaggtt cttatctaaa gcatggcgac 3312361 cgcttctgac acgtaagggc actttattct cacgagccca tttaatggca ttacttacat 3312421 cgtatgaatt ttgcgcaaaa acaaagacaa gaggatagac atccacataa gggttccaat 3312481 tcttaatagc ctctgtatag ccggggtctc ctttgaagat tacacgccct gtcaactgtg 3312541 ttgatcccat atattatttc actcccaaag aaattcgatt cagatactaa aatatgcagg 3312601 agctggataa tcgcatagac aaatgatcta cgaactataa atataatacg ctaaggcctt 3312661 tttcgtcggt gaggtctgct gagaaacatt tttcaaacaa ttttgagcaa acttcctgtc 3312721 caatcctcca acaagcgttt tttcttatcg tttttaggag cagtgtccag tttttttcgg 3312781 agtgaatatt cgtttaggcc aaaagaaaag agagatgaag aagtgtttag taccagaggt 3312841 atacatccat acaacagact ctagatcatc atatactgaa tgtatgtaga aaggagacat 3312901 cagctttggc aaaatatcgg attatgacct ttgacggcgg cggtacctta ggtgctttaa 3312961 gtttacaact attaaacaga ttggctaggc aaaacccgaa gttaattagt cgaacccatg 3313021 tattttcggg aaattcaatc ggttcattta ctgcccttgc attagcaagc ggaagatctc 3313081 cgagggaaac acttcagtat tttgaggatg aaatcctacc cgcattcagc atttcccggc 3313141 caggcggacc tgttttcaac caacaattac cctattccgg ttttattaaa gcggtaagaa 3313201 attttttccc agcagatctt caacttatag atttaagaaa acgaattgtt gtcccatcat 3313261 tcaaattata ctctcaaaaa ctggaccgtt ggactcctgt cttatttcac aattttcccg 3313321 gctctcccta tttaaatgaa aaagtgagtg atgtcatact gcggagcagc ggtgctcccg 3313381 cgacgcaacg cgcctatcaa aactatgtgg acggatatgt agtagcaacg aatcccagta 3313441 cagccagtat cgcgtttgca gttggtaaag ccaacgtgcc attggatcaa attgcggtat 3313501 tgtccatcgg aacaggtgaa gccccgactc ggttaagaag agatacgagg ggatggggaa 3313561 tggtaagtgc agataacata cgtcccgaaa atctgaagaa ccttcctcca aattggggag 3313621 tccttttgga caggtcgcct aatgaacctt tactgccatt tcttcagatg attgctggcg 3313681 gtaatgggta ctatgaatcc atggtcagtg cgaatcttct gggagatcgt tttttccggt 3313741 tagatccgcg gattccgaac ttctccaaaa cggaccctgc cgtcgttccc gctgtcattg 3313801 aaattgcgaa caaaacaaac ttacagcctg cgaatcaatt tatagagaag aactggggga 3313861 gcaaataatt atttatttta aatcaattct cgcttataca attttgtccg agagaagatt 3313921 ctcaaaataa atacaggcaa tgggtagaac cggatttttt taaaggtttg ttaatcacaa 3313981 gctaataaga tgaatgaaaa aatcaattca tacttcttct tttgaaagtg agggttcaaa 3314041 ctaaagaatg taattgaaat gttactctaa ggtatgcaat tccctttttc acacaaaaaa 3314101 agacaagagc ggcaaatcgc caaacccttg tctttcctgt tgttctattg gacgcgctcg 3314161 gagggattcg aacccccgac agacgtggta ccggaaacca ccgctctatc caactgagct 3314221 acgagcgcat atagactgcg ttatgagaac gtcagcacaa ctaattatac gataattcct 3314281 ttcaaataac aaccctctat ttcgagaggc cgttttttaa atagacaaag catcttaatt 3314341 ggcaatctga catacgatgg tttgaacccc tgtatttttg gggaaaatgg gaaaaagaga 3314401 cgactttgca tatcaggcca gctttttgtt tgacctttat tgaccaaaaa tgtatcatgt 3314461 aactacatac ttacctaaaa ggtgaaggag gagcattatg aatttaatac ctacagtcat 3314521 tgaacaaacg aaccgcgggg aaagagcgta tgacatttat tctcgtctat taaaggatcg 3314581 tatcatcatg cttggatctg cgattgatga caacgttgcg aactccatcg tgtcacagct 3314641 tttattctta gcagcagaag accctgaaaa agaaatttct ctttacatca acagcccggg 3314701 cggctctatt acagccggta tggcgatcta tgataccatg cagtttatta agccgaaggt 3314761 atctacaatt tgtatcggta tggctgcgtc aatgggcgcg ttcctgcttg cagccggcga 3314821 aaaaggcaaa cgctatgcgc ttccaaacag tgaagtcatg attcaccagc ctcttggcgg 3314881 tgcgcaaggt caagcgacag aaattgaaat tgctgcgaaa cgcattctct tgcttcgcga 3314941 caaattaaac aaagtcctag ctgaacgtac tggccagccg cttgaagtga tcgaacgcga 3315001 cacagaccgt gataacttca agtctgctga agaagcgctt gaatacggcc tgattgacaa 3315061 aattttgact cacacagaag acaaaaagta ataacacaac ctgcaagagc tgcgtctctt 3315121 gcaggttttt ttcatttcaa ggaattgact cccttattct atactgctcc cattcctcat 3315181 gtaacagctc aagcgtcaaa tcactcgtct gcctcacaac cagatcagca ccaagcatcg 3315241 gctgtccttg accgacacca accgcaaaca tccccgcaga tttgattgca gaaatgcctg 3315301 cttctgcgtc ttctattgcc gcgcaatcag caggggaaac atcgagcatc gctgcagctg 3315361 ttaaaaagat gtcaggatca ggcttcccct tcgcaagagt cgtcggatca acaatggcat 3315421 gaaaatcatc gataattgcc aagcgtctta aaatcttagg agcattgcga cttgaagatg 3315481 ctaacccgat ttttatattt tcgtttttca attgacatag aagcctgcca atccccggta 3315541 aaagatcttc cggcgtcaat ttgctgatca gcatttgata atcgcgattt ttccgatgca 3315601 taagctcttg tttctccgca tttgtatact ttgtttccgc cccgccaaag atcaatatgc 3315661 tttcaagtga ctcttctctg ctgattcctt ttagcctttc attcatgtct ctgtcaaaag 3315721 ggatatcgat ttgttctgcg atgtgcttcc aagcgagaaa atgatattca gcagtatctg 3315781 ttatcactcc gtctaaatca aaaatgaccg ctttcatata ctaatgccca tcacagcttc 3315841 ataaggtttg aggctaatac tctttaagtc agcccgctcc tgcggatagt ttgaaattag 3315901 cactttccaa cgctcatgaa tcagttctgg aggcgcttcg aacagagcct tttcttccga 3315961 taaattcaca acgacaagaa gcttttcccc tcgatattct cgaaggtaag aaaagacctg 3316021 cggatcattc tcctgcaaca gctgataatc gccatatatc ataatcttat attgctttcg 3316081 taattgaatg agcttctgat agtaaaagaa aatcgaatct tgatcttcca aagactcttt 3316141 cacattgata tcttgatagc gggaatttac cggtatccac gggtctccgg ctgtgaatcc 3316201 cgcatgtttt ccggcatccc actgcatcgg tgttctcgca tgatcccttc cttttatcat 3316261 cacggctttg acaaactctt tttctgacat cgttttgttt tcgacgacta gttcacgata 3316321 tgcattcttt atttcaagat catcatacat ctccagcggc atatcgctgt tgaccatgcc 3316381 gatttcttct ccctggtaaa taaacggcgt tcctttcatg ccgtgcagaa ccgttgcaaa 3316441 tgccttcgca cattccttac gcagtttcct gtcattgccc cagcgggaaa taaccctcgg 3316501 ctggtcatgg ttctcaaaat aaagggtatt ccagccgaca ttcattaacc cggtctgcca 3316561 ccttgtcatc gtctttttta aagcaatcaa atcaaacggc ttgatctgcc atttcccatt 3316621 tggcgagttt tgttctttat caatatccat atgttcaaat gtaaagatca tattcagctc 3316681 ttgcctgctt gcatctgtgt actttttcgc ctcttcaata tcagagccgt ttgcctctcc 3316741 gactgtcatg cagtcgtaat gagaaagcac ttccctgttc atctcttgaa taaactcatg 3316801 aagacgtggg ccgttagagt gataacggcc gacaatatag ctgcggctgt gatccgtttc 3316861 gtagtccgga aaatcggtgt atttagaaat agagccaatc acatccatcc gccagccgtc 3316921 aacgcctcta tccatccaga atctcattac atcataaact tcccggcgaa cggcttcgtt 3316981 ttcccaattt aaatcaggct gttttttcga aaagtagtgc aaataatact gccctgttcc 3317041 ttcatcgtat gtccacgctg agcctgaaaa gatcgatccc caattattcg gctctgagcc 3317101 gtccggttta ggatctttcc aaagataata atcccggtaa ggattgtcct tcgacttgcg 3317161 gctttcagca aaccaagcat gctcatctga tgtgtggttc acgaccaaat ccatgacgat 3317221 tttcattccg cgtttatgga cttcatcaat cagctgaaac atatcttcat ttgtcccaaa 3317281 cttttcgtac atgtttttgt aatcgctgat atcatatccg ttgtcatcct gcggggaatc 3317341 aaataccggg gagagccaga tgacatccgc cccgaggttt ttgatgtaat ccagcttttg 3317401 aatcacacct tgcaaatctc cgaatccatc tccattggca tcataaaaac tgcgcgggta 3317461 aatttgataa acgacagctt ctttccacca ttcactcatt aggcgttctc ctttcacatc 3317521 gtccctgtag gacaaccggt tcctcataaa cgttcatgtg cagcggctcg ccttttacaa 3317581 gctcaaaaat aacgcgcttt tcgtcaaccg tcacattgat taatcgattt cgataattga 3317641 tgttgaatga atattcgtcc cattctttcg gcaaaaacgg agcaaatgac agcgtctcat 3317701 tcgcggtgcg catgcctgca aagccatgaa cgattgccag ccagctaccc gtcattgaag 3317761 taatatgcaa gccttcttcc gtatcatgat tgtaattatc aagatcaagc cttgctgtgc 3317821 gcttatataa ttcgagcgct ttcttttcca gcttgagttc ggctgcgaga atcgcatgga 3317881 cagagggcga taggcttgat tcatgaacag tcatcggctc ataaaattca aaatttcgcc 3317941 gtttttcttc cattgtaaaa cggtcattaa aaagataaat gccttggaga acatctgcct 3318001 gcttaataaa attggagcgg agaatcttgt cccatgacca attctggtaa agaggccgtt 3318061 ccgctggatc taattcgtca actgtttgca ggtctttgtc caagaacgtg tcatgctgaa 3318121 cgaaaatttg cagttcttca ctaaatggat agtacatgtg ctggatgatt tctctccaga 3318181 cttccaattc tacttcctgc acatccagat ggcggcgttt ctccgctgag atactttcga 3318241 gactttgtag agtatactcc aacgtccaag ccgcaatgac attcgtatac caattgttgt 3318301 taacgttgtt ttcgtattca ttcggccctg tgacgccatg gatcatatac ttattttttc 3318361 gtttcgagaa gtgaacacgg tcggcccaaa atctgctgac tgccacaagt acgtctatcc 3318421 cgtattcttc catatagtta cggtcgcctg tataattgat ataattgtag atcgcataac 3318481 agatcgcgcc attgcggtga atttcttcaa aggtgatttc ccattcgttg tggcattcat 3318541 cacctgtgaa cgtcaccatc ggataaagtg cccccttcat ccccaatttt gcagcgtttc 3318601 gtttggcagc ctccaactga tgatagcgat acaaaagcag gtttttcgtc acctccggct 3318661 cggctgtcgc caaatacatc ggaacggcgt acgcctcagt atcccaatat gcggcacctc 3318721 catatttctc gccagtaaat cctttcggcc cgatattcaa acgggcatcg cccccgtaat 3318781 atgtcgagaa taactgaaag atattgtagc ggattccttg ttgaagctcc tcatctcctt 3318841 taatctcaat gtccgctttt gcccatcttt ccttccatcg atcagtgtgc ctccgttttg 3318901 catcttcata gccgttctct accacatccg ccaaaagctc cttggctttc gataaaagct 3318961 cttcctcccg aaaatcacgg gaagtcgtga caatcacaaa ctttttcaat gatgccttcg 3319021 tttgataact gtagcgattc tcgacataca tttcagtcgt tttaaagctt tcatggacaa 3319081 aaccctccgt ctcgtttgcc attgcggcta ataccgtgaa gcgcggtgtt ccaaatggat 3319141 tttcgatcgt ttttgccgct aaatggccgc tgtgagaatc agcacctttc gcttcctcct 3319201 gccaaaactg ttcttggtag ttagaatctt catttgccac atttccatcc aggtaaggaa 3319261 caagcgtaat gacagcatct cccgtcaagc actccgcttc ataatgaatc gcacagagtt 3319321 cttttacagc aaggctaaga aaccgctctg acctgattct gacggtttta tcttgaatgc 3319381 ggacaacagc gcttcgccgc agaatcccct ctttcatatt gagttctacc tcaaataatt 3319441 cgattgggtt ttgatggaga tcgatttttt caccgtcaac atataggcct atgcccataa 3319501 agttcatcgc attgatcact tttccgaaat attctggata cccgtttttc caccagccta 3319561 ctcgcgtttt gtcggggaac cacacgcctg caatatatgt gccttggtga ctgtcgcctg 3319621 aatagccttc ttcaaaattc cctctgaccc ccatatagcc attggcaaga gacgtcaggc 3319681 tttccagcag ccgtgtatgc tccttattaa atgtatttgt tttgattttc cattcatcaa 3319741 tctcaaataa ccgctgattt atcatcattt cctcccgaat gtaagtttcc attatcacgg 3319801 cgggttttgg tcaaatatct aaatgcaaaa gagatcatca aagtaacgcc acacgaatgg 3319861 atcatcaata cagtaatcaa atcaaaatga accatgccga tagcagctgc cgcaaatgcc 3319921 ggcagtgctg atgcgcaaat cgctatagag gccgcttcct tgaatgatgc aatagagacc 3319981 atgtttgata tttttgtgat ccagaggcca cctgcaagaa caaacgttaa caaaagctgg 3320041 atcatagaaa ccaccgtata tgccagcatc atgatcatcg gcttatactg tgccaaccac 3320101 aatgtatcga tcaagacctc tacatcatgg acgtttggtt tctcgagctt aacgtccatt 3320161 ttcgcatagc caacagaaaa ccccgtttcg ttttgatcgg tgatcaccag ttgatcaggt 3320221 tgaaatatga tggcgttttc aaatccagtt actttcaatc gcccattttc accgcttgtc 3320281 tcatattcat gcttcatatc gactgccatc acattctgcc catcttcaat cctctcagag 3320341 ctcttcccgc ctgttagttt tccgttcctg atttgaaaac cctgcaattg atcagcaaat 3320401 tgatcattaa ctccttgaat cgctgacggc atgaaagatg aaacgctgaa gcgatccatt 3320461 ttcacaaacg aaaccgctaa cggcgccatt aagcaggccg ttaaaaacag aaagagaaaa 3320521 gagagctgca gccagctgaa ggtattccca tagcggcaaa cacctgatgg ggatgcagcc 3320581 gccttcaggc agcggatgat aaagctttta ttctccagat tcttcattgg cattacccct 3320641 ttgttccgcc ggctgtcaaa ccggacacaa agttcttttg gagaaaaaag aatagaacgc 3320701 atatcggcag tgcggctagt atggcaccgg ctgcaaatag agctactttt tgctgctgcg 3320761 gattagaaat aaaggattgt aatcctacag cgatggtcag cctttccggt gagcgaagca 3320821 gaaatttcgt cagcaaatag tcgccaaacg gtgccataaa cgcccaaagc gcttgtaccg 3320881 cgagcattgg cttaacaagc ggtagaacaa ttgaagcgaa aatcctcaga tgtcccgctc 3320941 cgtcaattcg cgcggcttca tcaatttctc tcggcacagt atcaaaataa cctttcatca 3321001 gccacgtgtt catcggaatt ccgccgccga tatagatcgc tgttaaaaac cagtattgat 3321061 cgagtgcgcc tattagcatc gccaagacat aaaaagcagt cagcgccgcc attgtcggca 3321121 ccatttgaat gattaaaaag aatatcaggc tcttttttct gcctgcaaac cgatagcggc 3321181 tgtacgagta cccggcaagt gtcacaatcg taacctgcaa aaccatgacc gatagcgcga 3321241 tgacaagtgt attgctgtac caattgagat aaagcgtttc gtcaaatagc cgcttaaaat 3321301 gatccaatgt ccaagaaccc gaaaaatcga gctgaaaagc cgccgaattc cccacacgga 3321361 aggctgatga tgccgtaatc agcaacggat atataatgac aatacttaaa agcgtcaaaa 3321421 ataaatacgt acagatttta ttaagcattc tggcagtgct cgcgttcacc tacataacct 3321481 cctcattgcc aaaagcattc gattttttga aagcaatcag tgaaattcca atgacaatga 3321541 aagaaattaa cagtgtcaca gccgccgcaa cggaatattg gggtgatgtg cctgttgtca 3321601 gtttataaat ccacgaaatt aagatatcgg tcgatccggc cccggctccc gcactgcctg 3321661 gccctccctc attaaataaa tagatgatcg agaaattatt gaaattaaac gtatactgag 3321721 taatcatcac gggtgctgtg gcaaataaaa tcatcgggaa tgtaatatgc cgaaaacgct 3321781 gaataaaagt ggccccgtca atctttgccg cttcatacaa ttcacctgga atcgcctgaa 3321841 gcactcccgt taccatgaca tatatatatg gaaagccgag ccacgtttga atcataatga 3321901 gggctgtctt tgtccagaaa ggatcggtct tccacgcgat cgcaggcagc tcgacaaacg 3321961 gcaggtgatt gaataatggt atcacctgtg cattcaccgc tcctatgctg tcgttaaaca 3322021 tgttggaaaa actcatgatt gtaataaacg ccggaacagc ccatggaaat aagaaaatca 3322081 ttcgaaatat ccgcttgcct tttataaaat cctgattgac gaaaagtgcc gtcacaatac 3322141 ctaaaatgat ttgcagcgtt gttgcacaga ttgtccagat aaccgtccag cccagtacat 3322201 tcacaaatgt ttcacgatag gagccaagga aaaaaatatt taagaaattt ttaaacccga 3322261 cccagtcaat cagacgatta ggcggaatat gataaaaatc atagtttgtt aatgcaacaa 3322321 acagagtcac caaaaccgga aaaataatca caaacaccat catgatatat gccggcagtg 3322381 taaatagata cggaaaacct ttatcgcccg catgacagat catatccttg gctgttgtat 3322441 tgacttccaa acccgccgct ttcatagcgg cggtcttacg tgaatcatga atattaaaga 3322501 tatagaacat gaggaaaatc attgtcacga tcaattgcag cgtgccttca atcagcataa 3322561 acagcgagtg atcttcaccg ggaacacttc ccaatgtcat caatccggtt agcgcctgta 3322621 taccgaaaac gcataattca aaagcaaaca agcctgtgat ggcaagaaat aagagcccct 3322681 ttgacaactg ctgattcgca atctgcccaa gtcctggaat gatcgataaa agccctgcct 3322741 ttcgtttttg ctttgtaagt gtgtgatgtt tattcatttt tccgccctct attcttccgg 3322801 acgctatccc gccgttttat ttcacatact tttctttaat attttccttt atgacgttta 3322861 cagcatcatt cgctgatgtt tgtgtcgatt tttttcctga agctgcatca aaaattaaac 3322921 tttccgctcc tgtccatact tcagccattt ccggaatatt tggagtcggc gttgctgttt 3322981 catattgttt aatcacagct gacgtcagtt cattcttttg ctcatcggct ttcttccttg 3323041 cagccgtgtt ggccggaact tcgtttgtat cctcataaaa agcgtaagca ttggcatcat 3323101 ttgcagcata ctcaagccat ttttcagcca gctcgggctc ttttgtatat ttcgaggcaa 3323161 cccagccctt cccgccagca aaaggggcgt attcttctcc atttggcaat gtcggaatgg 3323221 gagccgctcc gtagttcaat ttagcctctt tatagttggc agctgaccaa ggaccgccaa 3323281 tgatcgcagc cgctttgcct tctaaaaaca tctgctgaat aaagtcgtct gcgcttgaat 3323341 tgtcttgcat tcctttcggc caatatgtct caaaccattt ctccgcatat ttcaccgctt 3323401 ctacagcccc tttattgttc aggccgatgt ccccggaatc tgtgccgttt tttccaaaca 3323461 catatccgcc gtatccagcc aataagccgt acgacatata aaagtcagtc cattttgcta 3323521 aaaatccggt tgattttcct ttttccgaag caaacgcgaa tcgaggatct tccgttaact 3323581 tttcaaggtc tttaaatgtt tttggcgctg tttttaaaag atctttgttg taatacaaaa 3323641 taagtgtctc aatgactagc ggcattccgt acactttgcc gtcaactgtc acctgctgca 3323701 tttctttatc accaaagctt tttgtgttag atggcttaat atcaagtaaa tgtccttgtt 3323761 gtcccaaacc gccgatccgg tcatatgcag caagcataac atcaggcgca ttacccgccg 3323821 ggccatcaag aggaagcgct tctaactgtt cgaacatttg cttttcaaca atttttactg 3323881 tgacatcatt ttctttttcg aactttgttt ttatgctttc aatgtattct ttatacgttt 3323941 cttcgacaga cacagtcagc acctttttgc catcagagct tgctggattt tttgaacttg 3324001 agcaggcggc aaggccgatt gccaggaatg atgccgccaa tatggcgaac ccctttttta 3324061 aaagaaccat ctcttttcct ccttctattt acgaaactat aacaattgta ttgtcctata 3324121 gaaagcggtt acaacaactt tcgatttgtt accgataaca gaatgttata caggggcggc 3324181 agcactcaaa atcaaaaatt ctcccggctg aacggcaatg acatcgtgat gctgtagcgg 3324241 ctgctctgtc catgcatcac agattttctt attcctatca atattcaact ctcgtaaact 3324301 gacgtgttga accacattcc cttgattaaa gaaataaatc agtatttttt catcaagagt 3324361 ccgcgaaaag ctaatgaaat catttttgtc gtccagcaga ttccactcaa gatgtccttc 3324421 agtcaataaa gtgttttcct gcttgcgtaa agcaattaac cgtttcataa attgcagcat 3324481 gtcttggttt tgcttctctt tttcccaaac catacatttc cggcataatg gatcattttc 3324541 gccgttcagc ccgatttccg ttccgtaata aatgcatggt gagcctgtct gggcaaacat 3324601 aaaggccagc aacgcgcgtg ctttcttctc atcattgcgg catctggtca aaaggcgctt 3324661 tgtatcatgg ctatccagta aattaaacat cacctcattg gcctgcttca ttccattcat 3324721 caaatgtgca ttgacacggt gagccatacg tgaagctgag atcgtctggt cagcaaagta 3324781 ttcaatcata ggctctgtaa aagggtaatt catcgccgca tgaaattcat cccctctaag 3324841 ccagggttcg gcagaatgcc agatctcacc taaaatataa acatcaggct tttcagtaga 3324901 tacagcctgc ctaaatgtct tccaaaaaac gtgatccact tcatttgcga catccaaacg 3324961 ccagccgtca atgtcaaatt cgcgaatcca gtacaaagca atatcaagca aatatttctg 3325021 cacctcggga ttagccgtgt ttagcttcgg catatcagct gtaaaagcaa atctgtcata 3325081 attgtcgtct gtgacgggaa aagagtgaat atggaaccag tccttatagc gggattgatc 3325141 tccgtttttg acgacatcct gccattgcgg agacgcgctt cctatatggt taaaaaccgc 3325201 atcaagcata attctcatcc cccgctgatg cagctggctg accaatgtac gaaaaagctc 3325261 aggatccccg aaatgcggat caatagaaaa gtaatccagc gtgtcgtatt tatgattaga 3325321 aggcgcggaa aagatcggtg tcagataaat gccgttcacc cctaaatcct ctaaataatc 3325381 aagcttgtca acaattcctt gtaaatcccc tccaaaaaaa tcattgacgt ccgggtcctt 3325441 gctcccccac ggcaatgcat tcttcggtga caagtcttct cttccatttg caaaacgctc 3325501 cggaaaaatt tgataccaaa ccgttgactt gacccattca ggcgcttgaa atgtatcagc 3325561 ctcgtgaaca aacggaaatt taaagtaata atgaatcgtt tccagtgttt tttcgttata 3325621 agggcataca cccgaacttc cgaaaaagat gtcttcatga tcgtctgtta caacaaacgc 3325681 atattgtaaa cgcctaaatg gcggcaccac ttcagcaaac caatagtcat gcatttctgt 3325741 agcagcaatt ttcctcatcg gctgctcgtt tgccgaccat ttgccgtcgt tgtactcata 3325801 gggatcaccc caaatgaatc gaatgtgatc tgcatcacct tttttcgtcc gaatcttgat 3325861 atgcacagtc cgcccatcat aagaataagc atctgtgctg aatggctggt gatgaatcgc 3325921 tgcatattcc atcatgtttc cccctttgat ttccgtttta ttgaagccgg ctcatagttt 3325981 gaaagtatca tgatgaaatt gtgggaacaa tccttttcac cctgttaccg ataacagaat 3326041 aaggcgctta cagcgttgat tctcgtacaa ttaactctgg ttcaaaaaat agacttcctt 3326101 gtgcagcgcc gtcttcattc atttttttca gcaacatttt cgcacaggct tcccccattt 3326161 caacaacagg ctgtctgacc gtagtcaagc gcggcgagga gatgcgatca agaaacacac 3326221 cgtcattccc ggtaaccgca acgtcttctg gaattcgctt tccaagggat tgcgccgcac 3326281 gaatgacgcc gagcgcgatt cgatcagatg cgcagacaaa tgcggcctga ttgtccatgg 3326341 atttcagcag ttctcttgca aggcattcac ttttcttaga actgttgtcg atccgaaaca 3326401 tattcgattt tttaaagctt ttattcatcg cccgtatata cccctgttct cttgcacgtt 3326461 cgaaaggctc atctaaatca atgccaaaaa agacaacttc ccgctccccc agccccataa 3326521 catggcgggt tgccataaaa gtgcctttct cgttattcac atcgataaag tcatagccca 3326581 tttcattttg tccaaatacg acgagcggct tctcaaaagc ttttattaca ccttcaaaat 3326641 cgttctttct caagccggtg gcaataatgc cgtcacattg gccaatatta agagaatttc 3326701 ttgtcacaag ctggagagca tagtgattgc gatccagctc cctgctgatt cctgtcagca 3326761 ggttcatgta atatggttct gtcgtatcca tttcctcaag tatcaatagt ttcacaacct 3326821 gtgttctgtt ttgcacgagc gctctcgccg cataattagg gatgtaattc agctctttca 3326881 tcgcagaatg aacaagcttt ttcaattcat ccgtcaccgt ctcagggtga ttgatcactc 3326941 gtgataccgt cattttcgaa acatttgctt ttttcgccac atctgacaat gttgccattt 3327001 tcatcccctc cttatctgtg cttattatcc aaactagtga taaagtcctc tattactgct 3327061 aaatatacga tgcaggccaa agagaaataa aaaagagatt tcccttaagg aaacctcact 3327121 ttgttaaaaa cactcgattt ttcatggatt catacgctag gtggcagact cattctctcc 3327181 acttccatca gaaaatctct tttttaaatt tctgtccact ttttttctaa aatcggataa 3327241 gaataatttt gcatttgctc aattaactca tccggccgtg acgagctgtg aatcagtttt 3327301 aggtgcgatt cgttagaaaa cccttcttga atgctgtatt tcaccatttt catcattggt 3327361 tcaaaatatc cgtttacatt gtacagtcca attggctttt ggtggatgcc gatctgtgcc 3327421 cagcacagca cttcaaataa ttcttcatat gtaccgaagc cgcccggcat cgagataaag 3327481 ccgtccgcca gctcgctcat tttagccttt cgttcatgca tcccgtttac ttcaatcagc 3327541 tcagtcagat tctgatggac aacctccccg ctgaacaaac cgctcggcat gaccccgatt 3327601 gcagttccgc cgttttccat aatcgcgtca gcaatcgtgc ccatcaagcc tacgcgggag 3327661 cccccataga caaggccgat tccctgctca gccatataca cgccaagctc tgccgctttt 3327721 cttttatacg cttcatttcc cccagggttt gatcccgcaa atacacaaat ggttttcatc 3327781 ttgtcatctc cgcatctata tatcgtgtta aacattcaaa aacacactat atattgtccc 3327841 atcttcatgt gataatatca atatgaaata cataaagaat gcaggagtga tgaggttgca 3327901 gctggctgat gcagaaaaat ggatgaaaga gttttacgaa aaaagaggct ggacagaata 3327961 cggacctttt attcgcgtcg gctttttaat ggaggaagcc ggagaactgg cccgggctgt 3328021 cagggcgtat gaaatcggca gagaccggcc ggatgagaaa gaatcgtcac gcgctgagca 3328081 aaaacaagaa ttgattgaag aaatgggaga tgtcatcgga aatatcgcca ttcttgctga 3328141 tatgtatggt gtctctttag aagacgtcat gaaggcccac caagaaaaac tgacaaaacg 3328201 atttgagcat gcataaaaaa gcggccgcga tggccgcttt ttttaacctg tgatttcatc 3328261 atggtgatca aagaaatgct gctttcctat tttgtgaaaa aggcctgttt tatgcagtag 3328321 ctccttcggc tgcgattgca atcctacaat catcagcttt ccattgtggc gtttaattcg 3328381 attcataatg ttcccaagca ccgcttcagc tgacgtatcc atatagtgca ccttattcat 3328441 gagcagaata agggttttcg gttttttctg tacatgctcc agcaatgacg attcaaggga 3328501 atcaattgat ccgaaaaaca gcggcccttc tatggcatac atgctgacag atggatcttc 3328561 tctcttcgcc agaacaggat gcgtttcctg attgtggatg cgggtcgctt cgctcattct 3328621 tctgataaag aacacgaatg caagcagcaa tccggttgcc acaccgatga ttaagtcaaa 3328681 cagaaccgta agggcgaagg tcgccgccaa aataaaggaa tcagcatttt tcagtctcag 3328741 catgtttgcg acttccttgc gctcactcat attccatgcg accaccatga gaatcggtgc 3328801 catactggcg agcggcacat gggacgcata aggcgcaaat acaagcagga caaggagaac 3328861 gactacgccg tgaacgacgc cggaaactgg ggaaaccgct ccgtttttta tattggtcgc 3328921 cgttctcgca atcgctcctg tagccgggat tccgccaaac aggggcgctg ccatattcgc 3328981 aatcccctgg ccgacaagct ccttgttgct gtcatgcttt gagcccttca tgttatcagc 3329041 gaccattgcg gacaaaatcg actcaagtcc tccaagaagc gcgatgacaa gcgcagccgg 3329101 aaacagcata accattttat ccaaagtaag ctcaggaaac tgaaattccg gcaaatggcg 3329161 ggggatttct ccataagttg acccgatcgt tgccatgcgg tcagggaaaa agacaaccgc 3329221 gaccactgtg gaaataagaa gcgccaacaa agcgcccggc actttaggca tcaccttggc 3329281 ggatacaagc aaaatgacga gcccgatcac agctgtcaaa atggcataca cgttaaaggt 3329341 gccgagctgc tgcacaattt caaacatgtt gtgatgaaag ttctcatgtt tttcaacatt 3329401 tctcaatccg agaaaattag cgatttgttc cgtaaagatc agcacggcaa ttccggctgt 3329461 aaaaccgacg ataacgggtt tgggcacgaa tttcattatt tttccgagct taaacagccc 3329521 aaacagtacc agcatcactc ctgccataaa ccccgcaatc agcagatttt ccaagccgta 3329581 ctgcatgata atgccgaata aaatcgggac aaaggcgccc gtcggaccgc caatctgata 3329641 ttttgatcct ccaaacaaag aaatacaaat ccctgctata acaacagtgt atagcccata 3329701 ttcaggctcg actcccgagg caatggcaaa cgccattcct aaaggaattg ccacgacacc 3329761 tactacgata cctgcaatca agtctttctg aaatttctgc aaattgtatc ccttgaatct 3329821 ccctgagaat cgcatatttt gttataacct cccttatgag tgattgttta taagctcagt 3329881 ttcataaccg ttaatgacca catcaagttt tcctgtttca gggtgaatga caagcccgtg 3329941 aaccggcact tttttcggaa gcagcggatg gttcttaatc atgttcacac tgtgggaaac 3330001 gctttcttcc acgctgtgaa aaccagtcag ccacgttttc aaatcgagtc cggcactcgt 3330061 cagcaaattc aggcagctat cctccacccc gcgttccttt gctttctcaa gaatcgagga 3330121 cgcattcagc cctgacattc cgcattcatg atggccgaca atgcatacct cttcagcctg 3330181 caattcataa atcgcgacca gtatgcttcg catcacgctt ccaaatgggt gagaaacgat 3330241 ggctcccgcg ttttttacaa ttttagcatc accgttttta agccccattg cttgcggaag 3330301 aagttctgta agccttgtat ccatacaggt gacaatgacg agctttttcg aaggaaactt 3330361 tgtcgttttg tacggttcat acttcttctc actgacaaac cgctgattgt gttccaaaat 3330421 tgatgttaaa gaaaccattt gattcatctc ccatccatat gattttgcaa gccttcttac 3330481 ccagcttaca gtaaggaatt atagcatagg aataagccaa gaaaaggttt tcaaaaaaag 3330541 acactataat tggactgtag aatcaaaaca taaacattta tatctttcaa agataataaa 3330601 atttatattt aatgcatcct ataatccggc tgcagttcgt atatcgatga tttgtctgac 3330661 aaaaaatatg ggtgaattct gataattaaa aaactttttt aagcagattt agctgttcga 3330721 tcttcatttt aagttcaaaa gaaccagaaa ttaaaaaaac gcagctatat ttttaacatc 3330781 tatttatttt cgatataatg aattagacaa cagccataaa gggggagcct tgttgaaacc 3330841 atttgtattt atcacaaaac cgattcctga agagattgaa gcattcatcg gtgaacattg 3330901 ccgttatgaa gtatggcagg aggatacgct tccgagtgac gtgctatttg aaaaattaaa 3330961 agaagcggag gggcttttaa catcagggac gtccggaccg tcaatcaatc gtgagttgct 3331021 ggaacacgcg cctaagctca aagtggtcag caaccaatca gtaggctacg ataacttcga 3331081 tatagaagca atgaaagaaa gaggagtcgt cgggactcat acaccttata cactggatga 3331141 cacagttgca gatctggctt tttcactgat tctgtcttcc gccagacgtg ttgccgaact 3331201 ggaccgtttt gtcagagcag gaaaatgggg aaccgtggaa gaggaagcgc ttttcggaat 3331261 tgatgttcat catcaaacgt taggcattat cggcatgggc agaattggag aacaagcagc 3331321 gagacgcgcc aaatttggtt ttgatatgga agtgctttat cataaccgac atcgcaaaca 3331381 agaaacagaa gacagcatcg gcgttaagta tgcagagctt gatacattgc tggagcaatc 3331441 tgattttatt cttctcatta cgccgctgac tgatgaaacc tatcacatga taggagaacg 3331501 cgaatttaag ttgatgaaga attcagcaat tttcgtcaat atttcccggg gaaagacagt 3331561 tgatgaaaaa gcactgattc gcgctcttca ggaaggctgg atcaggggag ccggcttaga 3331621 tgtatacgaa aaagagcctg tcacccaaga taatccgctc ctgcagctgg ataatgtcac 3331681 gctgcttcct catatcggtt cagcaacagc taaagtgcgc ttcaacatgt gcaaacaggc 3331741 cgccgaaaat atgctcgcag cgatccaagg gcaaacaccg aaaaatctta caagagaatt 3331801 tcaataaatc aaaaatccgg tctgataaca gaccggattt catattacat acgctgaaga 3331861 acagcacgct tataaatatg acgggtgacg atataataaa gagcctggaa tacaaaataa 3331921 atgaagatga caattacggc ctcaagaaat aaattggaat tcagcatatt acttaacgct 3331981 gcatacgcaa agcccgcgtg aatcgtacct gcgataaatg ggatgaagaa taaaaatcct 3332041 atttgctttc caaggatcga gtgaatctct ttgtccgtaa cccctatcct ctttaacgct 3332101 aacacctgca ctcccgtatc ttctatttcc gtaaacatcc gcaaatacag catgcttcct 3332161 tgcacgataa aaaacagcac gctgacaaac agaccaataa acagcattaa tgcaactccc 3332221 tgcttcacaa tttgataact aggagcacgt gtttgaaaat cagatgtatg ttctttcggc 3332281 accatgtttt caagcttttc agagacatcc accgtctcct gccaatgctc aagctcataa 3332341 cctaccattc tcatctgttc cttcagcggc acatcctgtg acagactgtc aaagctcttt 3332401 tcgctgacaa ccaataaacg gctgactcca tcgacagaca tcaatatccc tttgttttgc 3332461 tgctttttca tgacatagga aagggttttt cctgacttca tatgaaatgc tgctgtttcc 3332521 ccttctccaa atgtgtcttt caccatcatt tgaaaagaaa cattaataaa tgcttcattt 3332581 tcttgtaaat gaataactgg gaaccctttt tcctttgcga cttgattata gactttttct 3332641 gaaatcagca aagcttcagc ttccatcttc ttatttccat acggcaagtc tgactgaaaa 3332701 gtgacaggaa tccctgtggc atccacctta tacgtgataa cagcatgagc ttttttcaat 3332761 gtattctcag ccgtctcagg cttcatgacc tgaaagcggg aagcatcctt ttccacccag 3332821 gaaacagact gaggaatgct ttgctcctcc tgcctttgta aatcggaata aaacatatag 3332881 atgacacctg tagctgttag tatgaccgct gtaatgacag aggttaaaaa cagcatgcgt 3332941 gcatgatcct tcagcctgaa tatcatgttg gaacgcacaa tgatatttgt gcctttgtag 3333001 aagctgtgtt tctttcggta cagcatgcgg aaaaatgcca cactgctttg ggtaaaaaag 3333061 aaatacgtgc caattaacac taaaatcaaa attggaaaaa cccgaaacat catgtcaatt 3333121 gcattggctg ttgcagatag ataataaccg ctgccaagac atagcaaaga caatacagtg 3333181 agccatttcg aataaactgg caaacttttc ggctttttgg ctgatttaat cagttcaatg 3333241 atttccagct tccgaatccg tcccagtgat aaaatgagca gcgtctgaaa caggatgaga 3333301 aagccggcaa ttgtcatcac aaacgctttc ggcacaatgg caaacgaaat cggcaccttc 3333361 acgctgagca tccatgtcat gatcataaaa aacagttttg aaaataacag gcctgctcca 3333421 atgccggccg caatcgccgc aagagaaata agtgactgct cataataaat catcttgcga 3333481 agctgctgct ttgatgtgcc aaacagtgtc agcagcccaa actctttctt tcttgcctgc 3333541 aaaaacgctg aattggaata tgtgatgaaa aatatacaaa acacaatgat gacgacaaga 3333601 gctgcgctca agcatgtttt gacaaggctt cctccatata tattgtcttc attgacatca 3333661 ggatgaaaaa taaatgatgt gaagacaaaa aacaccgaaa cggcaaacac acagcttaaa 3333721 aagtaggcca cataccgttg cagattccca agaatgtttt tacgggcgat agttctcaaa 3333781 ttcatgaaaa tcgcctccca acacactcaa ggtatccaat atactttgat aaaacacctg 3333841 cctgtttgtt cctctgtgaa tctctgaaaa gaaacgtccg tctttaataa aaacaatccg 3333901 tttacagaaa cttgctgctg tggcatcatg cgtaaccaac aaaatcgtcg cttccttttc 3333961 ctcattcagc tgagccagtg tgttcatcac ttgctttgcc gattttgagt cgaggtttcc 3334021 tgtcggttca tcggcaagaa tgagcgccgg attgtgaata atcgctctgg cacaagctgc 3334081 ccgctgctgc tgtccgcccg acacctcata tgtgcggtga tcgagaatat gctttatttg 3334141 cagcgtatcc gccagttcat ccaatcgagc ttccatttct ctcagcttta ccttatccaa 3334201 tgcgagcggc aagagaatat tttcacgaat cgtcagcgta tcaagcagat taaaatcctg 3334261 aaagacgaag ccgagttctc ttctgcgaaa caaagccagc tcttggtcct ttaacgtttt 3334321 cggctgaatg ccgttgatca tcatctcgcc ctgggtcggc ttatcaatgg tagccagcaa 3334381 attcaaaagc gtggtttttc cgcttcccga cggccccata atcccgacaa attctccttt 3334441 tgacacactg agatcaaagg cgctgagcgc ttggtatgat attgttcctt tatttgaata 3334501 gtatgttttc gataggttcg ttgtttgcaa cacgttcatg ttctgctcct cctttttctt 3334561 tattataaaa aggaagtcag catcctccca tcgaactttc ttgcaattcc gctccccaat 3334621 cttacaatgc tgtcacattc acgagggtgt cacttgaaaa cacgatggtc atcacagtgc 3334681 cagccccttc ttttgattcc gcatacagct tatggccgag acggctgcac acctgttttg 3334741 ctaaataaag gcccattcca gttgcctctt tcatggttcg tccgttttct ccggtaaaaa 3334801 acgcgtcaaa aatccgcggc agatcctgcg gcggtatgcc gattccttcg tcggcaaccg 3334861 acaagcgcgt ctcatgtccc tgtgtttcaa tccggattgt aatagggtct cccacacctt 3334921 gctttgaata ttttaaggcg ttgaaaagga tttgctcaac aacaaaggaa agccactttt 3334981 gatcactgga aatctgaacg gcatttggcg gcacatgtaa tgttggaaaa aggcgccgct 3335041 tgataaactg acgtttttcc tgattgatca gtgaacgaac catttctgcc aaatcaaagg 3335101 tttgcggctt tacatcaaat gcaaattcct ccagccgggc cgtttgcagc atcatatcaa 3335161 gaccgtggcg aaatctctca ttctcatcct ccagctcctc taaaaacgtc ggaaaagagg 3335221 atgaggttcc gttttttcct tcctgaatca ttaaggatat gacagatacc ggtgttttca 3335281 tatggtggac ccattggttg gtgaaggtgt aatgctgttt ttgctgattg atatattgtg 3335341 agagcctgct ttcgtattgc tgcccgagtg cgttgatcat cttcgtccaa agcgcttgct 3335401 ctcctgttct tggctttctg gctttcaaag actgtccgat gtcattcgaa gaagaggctt 3335461 gttctgcaag ctttttaaca tatgtgagaa aggaaaattg ccgaacataa tcagcagcaa 3335521 aacctgcggc taaaagagta ccgggcaaaa tccatatgta catcatattt tctttggaag 3335581 gttctgcgcc gctctctaca atgcttaaat acgcaatcag catggcggac cctatcccta 3335641 ataatgaaaa tagaataatg gctaagcggt cgatgagata agtctttaac attccgcttc 3335701 atccttccga ttgacttgaa attgataacc ttgtcctctg attgtggaaa tgcaatctgt 3335761 cagtcctgca ttctccagtt ttctccgcag ccgattgaca ttgaccgtta acgtattgtc 3335821 atcgacaaaa tcaacgtcat cccataacgc ctccaatagt tcatcacgag agacaatttt 3335881 tttatgctcc ctcacaaaaa tcgagagaag ctggaattct ttttgggaaa acaaaatccg 3335941 gacgctgttc cattcggcct cattctgatc aggataaatc gtcagcccgc caagctccac 3336001 tattctagat tcctgcggca aagagggcga atattcacca tatgtgcggc gcaggacgct 3336061 tttgattttg gccatcacta cctctagatg gaacggcttt gtgatataat catcgccgcc 3336121 attttcaatc gccattacct gattcagctc atcggtccgt gccgatataa agataatcgg 3336181 cgcattggaa atggtacgga tttgcctgca ccaataaaac ccgtcaaaaa aaggcaggtt 3336241 gatatcaagc agcacaagat caggcttcat ttctgcaaat tccaatttta tatcattcag 3336301 ctgttcagca attttcactt catatccgta tttttgaaga tgaccgccca gcaaagaagc 3336361 aatccgctca tcatcttcca caagcaaaat ccgatacacg ttgatccccc ttatatgtac 3336421 atcacgatga tttttctaga agattccaaa attattatag catgtgcgga atagtaaatc 3336481 ggtctttttc tttttgttat gatagaatga taaaggtaaa attttcataa taggcaggtg 3336541 tcgtgatgaa gaaaatcatg ctgtttctgg caatgacgtc aattctttca gcatgtcagc 3336601 ccaactatac cgggaaatac atagaaattg gggatacact aactgactat accaaagagt 3336661 gctttaaaga gaatgaaatt ccttataaat acgaaaaggg aaaactgtat atcccagaag 3336721 acgcatttga tacagcaatc tacacttgtt cataagaaaa agcttgcaga taacctgcaa 3336781 gcttttcacg ttacaaaaaa tgagtattta atttctcttc aaatcctgaa gggccgatgt 3336841 cgcttttttg aatgttaccg ccgttttcat aaatcgtaaa atggcgctct gacatgacca 3336901 tccttccgct cggcgtcagc tttgaggcaa gcagggattt gttaaaagga gatttttcat 3336961 gagagtgaat gatgtccttc atgttatcta aatcaccgag atcactctct tcaagggtaa 3337021 aggcgtaccc aatttgccag ccttctcctt tgtccatcag cagaacatag ctgccctttt 3337081 ctgtctcttc ctttttgatt cggaatgacc cgactggtga ctgtaccgtt tctccggaaa 3337141 gcggtatcgg ctggagcgcc aggttgatgc cgaagccgat atcaacgagg taatcgccgt 3337201 tttccgcaga cagccataca gcagcatgcg tcccttctag tgcccatccc tcttgatcgc 3337261 ctgcataaac cgttcctcga atgagcttca catgaaaccc ggcctcacgc aagacaaaat 3337321 aaaggaaacc atttagatcg tagcataggc cgccgtgctg atctttgagc agacgtcgcc 3337381 atagctcttc ttttgtgatc ttataattct cttttgcaag tacggcacgg ttttcgaatg 3337441 gaaaacggta tgccattgct ttaagaaaaa ggggaagatc gccgaagctg acatggtctt 3337501 tctcccagcc gattttctga aagcagtctt ttagaaagtc actcattttt atcacctaaa 3337561 cttcttcttg aacgtaagca gccagcttct ccagcgcctc ttgttcatct tctccctggg 3337621 caatcaaggt aacctcagtg cctgtgctta ccgcaaggct catcagcccc atgatgcttt 3337681 tggcgtttac ttttttccca tccttctcaa gaaacacatc tgacgtaaac cggtttgctt 3337741 cttgtacaaa caaagcagca ggacgtgctt gcagtcctgt ctttaatcga acttccactt 3337801 tctgttgaac cataagatct ccccttttct ttacggttat tttaaagtga cggtttgccc 3337861 tgtccgcagc tgttctgcga tttcgtcaag ttttctcagc ctgtgattga tccctgattt 3337921 gctgattttc ccgcttgcta ccatttcccc tagctctttc agcgtcactt cctgataatc 3337981 aatccgcagc tgcgcaattt cccgaagttt ttcaggcagc gcctccaggc cgattctttc 3338041 atcgatgtat ttaatatttt ccacctgtct cagcgatgcg ccgatcgttt tgtttaagtt 3338101 ggctgtttca caattgacga ggcggttgac cgaatttctc atgtcccgaa cgattctgac 3338161 atcctcaaat cgcagaagcg aattgtgagc gccaattacg ttcagaaact ctgtaatctt 3338221 ttcagcctct tttaaatagg taatatagcc ttttttccgt tcaagcgttt tgctgtttaa 3338281 ctgaaactca tttaacaggt cacataatga atcgttatgc tccttataaa gagagaagat 3338341 ttctaaatga tacgaggagg tttccgggtt attgaccgaa cctcctgcca aaaatgctcc 3338401 tctcatataa gaacgcttgc agcatctctt tttgaccagc tctttcgaaa tacttcgttc 3338461 aaacacaaaa ttctccccga gtatttttaa atcctctaag atcgcttttg cattttctga 3338521 aaaacgcaca atatagacgt tattcttttt cagccgcatt ttctttctga ccagcagctc 3338581 gaccgacaca tcatattgtt ttttcagcaa tgtatagatg cggcgggcaa tcgccgcgtt 3338641 ttcggtttga acatcgagta cgagatggcg gtttgtaaat gataaagctc cattcatccg 3338701 aatgagtgca gacagctcgg cattaatgca gcagtccttc acttccagat tcgttaattc 3338761 tttttttgtt tctgatgcaa atgacatata gccacctcat ttcaaggctt cattctttca 3338821 gtaaatcaac aagaagagag gccactttat gtgtatcgtg acgtattacg tcatttttat 3338881 acgttacaat ttgatctctg atgacttcaa gccccatcgc tttcagctct tcgatatcaa 3338941 aatcaacagg acgcgccgat tccatttcgt acttacgttt tatttcgtcg ggaatgtctt 3339001 cactgttcac taatatcgta tcaataaaac cacagcccat atgctgattg agcgctttca 3339061 catgatcagc agcggtgtaa tggagcgttt cgccgggctg agtcatcacg ttgcaaatgt 3339121 atactttttt cgccggcgcc tttatcactt cttccccgat ttttgggacg agcaaattgg 3339181 gaagaatgct ggtatagagg cttcccgggc cgataataat caaatccgct tccctgatta 3339241 cgtctattgt ttccggcagc ggatcaatct gttcaggcgt gagaaaaaca cgcttaatgc 3339301 gctgtccgta ttctgggatc gttgactcgc ctgagaccac gcggccatct tccatctcag 3339361 catgcaaaac gacactggca ttggcagccg gcaaaacctt tcctcttaca ttcagcacct 3339421 tgctcatttc tgtgacagcg tgaaaaaaat caccggttat atttgtcatc gctgccaaaa 3339481 tcaaattccc gagagaatgg cctgttaagt cattcccttt attgaagcgg tgctgaaaaa 3339541 gatcttcaac aagcggctcc acatcggata aagcggcaag cacatttctg atgtctccgg 3339601 gaggcggaat tttcagttca ttccgcagac ggccagagct ccccccatca tcggcaactg 3339661 ttacaatggc cgtgatgtca acgggtttat gctttaggcc ccgaagcaat acagaaagac 3339721 ctgtaccgcc gccaaagatt gcgattttcg gcttttgtcc catcttattt ccggcttctc 3339781 ttttcaatgt cccggtgagt aacatgagta tagtaatcct ttttgaaata atcagctaaa 3339841 ttctcggcta atgtcacaga gcggtgctgg ccccctgtgc agccgatcgc aatgacaacc 3339901 tggctttttc cttctctttt gtaagatgga agcataaagc tcagcagatc aattaatttc 3339961 tcattgaact tttgcgtttc attccacttc atgacgtaag aggaaacctc tttatccttg 3340021 ccagtcagcg gccgcatgct ttcgatatag tacggattcg gcaaaaatct gacatcaaag 3340081 acgagatctg catcaattgg aataccgtat ttaaaaccaa atgacatcac atttacggta 3340141 aatgtctctc cttggtttgt cgcaaagtgc ttcacgattt tttcacgcaa atcacgcggc 3340201 ttcatgtcag acgtatcgta aatgatttga gagcggcctt ttaattcctc aagcagctct 3340261 cgttctagcg cgatgccttc aagcggcagg ccagtcgctg ccagcggatg cgagcgtctc 3340321 gtttctttat atcttgtgac gagaatggaa tccttcgcgt ccaggaataa aattcgcggt 3340381 gtgatccacg gattttcggc catttcatcc agcgcttcaa tcagccggtc aaaaaattcg 3340441 cggccgcgca aatccatcac gagcgcaact ttgctcattt tcgaatttga ttccttcatc 3340501 agctctaaaa acttcggaag caatgaaggc ggaagattat cgacgcagaa atagccgaga 3340561 tcttcaaagc tttggatcgc gacagttttc cccgctcccg acattccagt tataatgaca 3340621 agctgaatat catgtgattc actaacactc atctttctcc cccctgactt gtctttctat 3340681 ttgatgtgct gcgggtctaa acgataactg agcagctcaa attccggtgt atacgtaaat 3340741 gtgccgtgca gcagcccttg tcccttcatc ataaaatcaa ggatatggcc gtctccaggg 3340801 gccataggca ggttctgaat gtcattgaca tcgtgccact gcagtttgcc ttcctctgat 3340861 tctgatacat tttgtcctgt atatgaatca gcgacaaacg taaacatcat ccactcggag 3340921 acaatgtggt caccgtcttt aataataaag gtaaaaacgc cttttaattg aggatttatg 3340981 atatagatac cagtctcttc tctgtactct ctgatgacgg agtctctgac tgattctccg 3341041 ctctccatct tgcctcccgg cgcgacccac catccgcgtc tcggcttttg aagcagaaga 3341101 actttgtcat ccgtctgaag cacacaattt gtcactcttt gcaagtacgt cacctaacct 3341161 tcgtcctgtc atcgtctctt tattataccg cttcaagatg cctcccacaa tgaagagaca 3341221 ttgacaatct tttcttctat tttacagcat attcattcct taattcagat gattttgctg 3341281 taactggaat tctcttttat ttatggacaa aaaaaggaca cggataactg gagaatccgt 3341341 gccaaaaaag tgtattcatt ataaaaaggg ggtcaattac tttattaatc ataaccgaaa 3341401 agcattacac atgtgttaca gcggaattaa aacccagtaa cgtaatgtga aactcgtatg 3341461 acagcccttt ttattttaag gttttcagcg tttcttggag ctcttcgaca taatgttgta 3341521 cgctttgtgc cgcaatgctt ccgtctcctg tagccgttac gatttggcgc agtgattttt 3341581 cgcggatgtc tccggcagcg aaaatccctt caaccttagt ttccatgcgg tcgtttgttt 3341641 cgatatagcc ttcttcattc gtaatgccca ggttttcaaa cggtttagac agaggaagca 3341701 tgccgatgta aatgaatacg ccgtctgttt tgaattcact ttcttcaccg gttaccgtat 3341761 cgacaagcgt tacgttaccg actttgccgt tttcctcatg aatttccttc acagttttgt 3341821 tccataggaa gtcaactttt tcattatcaa atgctctcgc ttgaagaata ctttgagcac 3341881 ggagtttatc acgtctgtga acaatcgtta cttttgaagc gaaacgagtc agatatacgc 3341941 cttcttcaac cgcggaatct ccgccgccaa caacgacaag ttctttgcct ttaaagaaag 3342001 cgccgtcaca tactgcacaa taagatacac cgcgtccgcc caattctttt tcgccaggca 3342061 cgccgatttt tttatattcc gcacctgcag caatgatgac agcacgggct ttatattcct 3342121 ttgaaccagc tttgactact ttgtactctt tgccgtcaat gacctcttta atatcgccat 3342181 aagcgtattc agcgccgaat tttttcgcgt gttcaaacat tttgttagaa agctcaggcc 3342241 caaggatact ttcgaatcca ggatagtttt ctacatcttc cgtattggcc atttgtccgc 3342301 caggaattcc tctttcaatc attaatgtcg ataaattcgc tcttgatgtg tatacagcgg 3342361 ccgtcatccc agcagggccc gcgccgatta taatcacgtc ataaattttt tcttctgaca 3342421 cactattcac tccttaaacc atcttttcaa gtttgggctc tttcttataa gataagaatc 3342481 cccatcaaac gtattcctta cccatatcct ataaaatctc atggtgatac gctatttttt 3342541 tgctcaacac gattaaatgt attcgaaaag ggtatatgtt aataaagaaa gagccttctg 3342601 tttatagaag gcccttgtca tatttattat tgaacaacac gtcttacaac acctttaaat 3342661 gctgctttcc agtaaggatt gctcatagag tcaacagata cgccatgaga tgtattgtcg 3342721 tttaggaaag taccgtttcc taagtagatt cctacgtgtc catttgtttt gtaagtgtca 3342781 aagaacacaa ggtctccgcg tttcatttca gacgcgctga cagcttgtcc tctgccaact 3342841 aacgtatcag ttgttgttcc gcctacaggt ccaaggttaa cacctgcaga agcgtatgcc 3342901 cagcgtacga atgatgagca gtcaaaaata cggttgttga tatcagactg agtgcgtccg 3342961 ccgccaaact tgtacggaga ttgtcctaca atgcttgaac caacgctgat cgcgccttca 3343021 attccgccag agttgctgat aacagtgccg cctgaattgc tgtttgagcc gctgctcttc 3343081 ttagaagatg agccgtttga cgaactgttt gatgaaccgt tagaagaatt gtctgaagaa 3343141 ttgtctgaag aatcatcaga tgagcttgct tttgatgatt cagttgtcgc cgtttgactg 3343201 tcatctgttt gtgtttcatc agatgctttt tgtgcttctt cctgcttttt gatcaaagca 3343261 gccgctgctt cttgttcttt tttgatgcgt gcttgttcag cttcagtatt tgctttttga 3343321 tttgcaagtt cagacgcctc tgattttaat tcagaaatcg ctttagccgt tttcttttgg 3343381 cttgcttttg cttcgtcgaa aagcttgtct ttttcattaa gctgtttatc aaggtctttt 3343441 tgcattgttt ctaatttagc caaggcagct tgaacttctt tcagcttgtc attcaaatcc 3343501 gcttcagaat cttcgagctt cgctttatcc tgctcttgct gtttgattaa atctttgtct 3343561 gcgtccacaa tagatgaaac cgcagtcgca cgagagataa agtcaccaaa gcttgttgat 3343621 cctaaaagaa catctatgta tccttgagat ccgccgcttt cctgtaaaga acgaacgcgt 3343681 tttttcagga tttcattgcg tttttcgatg cgtgcttcag tttctttaat ctcttttttc 3343741 agttttttga tttcttcttt tgttttatcg ttttcttctt ttttatcttc aatcttgttg 3343801 cttgtatcaa gcgccttatc gttaatgtct ttcagttctt tttcaatctt tgattgattt 3343861 tcctgaagct cggttaattc tttttccttc gcttcaatgc tggaagcaac ctcagattgc 3343921 ttgctttcga ttttttgttt cttttcatct aatgtttccg ccgatgcagt tttacttgta 3343981 aatgggatca aaaaactgct tgtcccgatg acggaagcca aaccaagtgt aattaaactc 3344041 tttctcactt tttatatcct cccttttact gtgaacctgt cctcatttgg aatcgtattt 3344101 tgaacatcaa gtttcgttcc tcatactcta cgaggaatga tggttgttta tggttaatta 3344161 ttctgtgcat ctcttattct ggttgtatag cgtttatttc acatcatatg taaaaaacac 3344221 taattcctta tgtacgagaa tcattatacc atcaagtttc gacaaattag cgataaattt 3344281 tattacattt atgtttcaaa cagatgtcaa gtcacacatc atttgtcatt tttcttaagc 3344341 gtgtaaaaaa actgtcgata ttattttctt aatataatct atctaacaaa aaaagagtcg 3344401 attaaataaa tcaactcttt aaaatttact attctagaat atcatcaata tatttcatat 3344461 atttcgtcaa agttgccgga gagatgccga atcgggccgc tgtgtctttt ttcgtgtctt 3344521 gcttgccatg ggcttctttc caaatataac agatggctgc tgcccagcct ttctcattct 3344581 tcaacggagc agctgcacga atttgctgga tgacatgaaa aacccagcag ctcatgactt 3344641 ctgttttcat ctcttctttt tcagcttgct ctaatagttt gaccgtttga taagcgaaaa 3344701 gtgcatcctc tgaaacgtca gcagccgcag aatctccatt cagaagcagc tttacaaaat 3344761 gagtttcaaa aggagcggta attctctttg agcgtatcac cgcttcaaga tgctctgttt 3344821 ctccctttgt gctgctgata taataggctg cgagtcgctg ctccacagat gaaggaagag 3344881 cttccctccg ctcaatccaa ggcgccgggc ggtcttcgcc gggatattgc gactcgactt 3344941 ttctccagat cgtctcggca aagtcggtat gtcccgtaaa ataagcagag caggaaagcc 3345001 agtaaaagaa ggtgtcgtca ccctcaaagc cggttttata taatgatttg agccatttat 3345061 atccgatctc gtagcggccg acaagcgcca aagtagcacc caatttataa cgctgctcca 3345121 atagcatcgg atagacattg gagagctgat cactcaattc cgccactttt tcgtcttctc 3345181 tttcataata gtagaaaacg agaagattgc ataaggcgtg aagatttcct tcattatgag 3345241 aaagcacttc ataagcggtt tgcttcgctt ttacaacgtt tcctgaatag aaataggcaa 3345301 gcgcgagatt gttgtatgct gaccaaagct ccggatattc agttgtgatt tcctcaagcg 3345361 ccgcaaccgc ttcagcaagc tggccgcttt ccagcaatga ctttgcccga tcctgtttca 3345421 ccagcagttc atcctgatca tacaacgaat cctcaatgcc gtcgtctcct aaatcgagca 3345481 aatcaagcag actatcgttt tcttcggcga attcaccatc cgggtccgca tcagaataag 3345541 cggccgcttc tttataagct tcctggaaga gccccagatg ggcaaagtta ttcgctttaa 3345601 agtaatggca ctccggcatt tcggcctcca gatttgccat gatatagtca agaagatcgt 3345661 tcgactcttg atactggccc atttccgaat aaatgaccgc aagctgtgaa agcatctctg 3345721 aatcctccgg ctccaaatga accgcgcgct gaatcagttt gcttgcccgt tttagattgc 3345781 gctctttata cgctttcaag cctttatgaa aaaaatattg tccatcttga agcagctgga 3345841 caatttgtgc gtgattttta tgttcagaag tgtgttttcc cacaactacc ctccgtttta 3345901 tacaatatta ccgtcagtag tataccataa atcgtaagcc cctcaatagt tcaaaaggaa 3345961 ggattgggaa aatccctcct cttttttatt ggctgattcg accaaaattt acccggcttt 3346021 gttttctaag tccgcattca ttttcagctg ctgttcagca aaatcccggt aaaggccatg 3346081 ggaagccatt aactcatggt gtgttccacg accggtaatt tccccttttt caacaaacaa 3346141 aagctggtcc gcatctacaa cggtagatag gcggtgagcg ataacaatcg ttgtgcggcc 3346201 ctccatcagc acctccagcg cctgctgaac tgatttttca gattggctgt cgagacttga 3346261 ggtagcttca tcgagcataa gaatgcttgg gttacggaga agcgctctcg caatcgcgat 3346321 tctttgcctt tgtccgcctg acagcataat gccgcgttcg cccacttctg tatcaaactg 3346381 attcggcagc tcctttataa aattgagcgc atatgccatc tccgcggctt tttcgatctc 3346441 agcatccgtc acatctcgtt ctaacccgta gcaaatattt tctctgattg tcccggacat 3346501 taacgggctt tcctgtgata catacccgat atgctccctc cacgattcaa gcgagtaagt 3346561 atcgaccggc tcgtccccca gccgaatggt ccctgcagtc ggagaataaa agcgttcaag 3346621 cagcttaaac agcgtcgttt ttcccccgcc gctcggaccg acgatcgctg tcactttccc 3346681 tgcttcaatg acggcgctga cctcttttaa gatcagctga tcaggcttat atccaaaaga 3346741 cacgcgatca agctggatag gcagatgtgc attttcaatt tgttttcctg tcactgtatc 3346801 ttcctcttcc tctgccaaaa tctcaatcat tcgttctgtt gcaccgattg atttttgcag 3346861 ctgtgtgaaa aacgttgtaa tctggcccat cggcataata atttgaaaca aatataaaat 3346921 aaaagccacg agcgctccgg ctgtgagctc gcctgatgag acctgcatgc cgccatatcc 3346981 gatcactgcg acaagcgctg ccattaacac gagtgaaata agcgggccga caagcgattg 3347041 aaccttggct tcacgaacgc caagcttaaa taatgaggaa atccccatct tcccgcgccc 3347101 atattcgaca tcctccgcat ttgaagcctt aacaagtctg atttccggga gaatttgatt 3347161 aagcaggcct gtaaaacgag ccgtttcatc ttgcgtttcc cgtgaaatgg agaacatttt 3347221 ccgtccaatc ggcaccaaaa taagagcggc cagcggaacg accactaaca caagcagtgt 3347281 cagcttccag ttcataataa acaagattgt caatgatcca atgacagaaa tgatgcctgt 3347341 aataaatccg ctgatatggg ttgtaatcaa ttctttgacc accatcgtat cgttcgttac 3347401 acggctgact gtttctccgg aagcatttgt atcgaaataa gagacaggca gcttaattaa 3347461 tttcttccat aataactccc gcagcccgga aatgattttt tgtccattat agttaagcgc 3347521 ataggtggca taagcgctta aacccgcctg aacgaaaaac accagcgcga tcaaaccgat 3347581 ttgcgtgcct gacagatttg acatagaaaa accatcgaca agctgcttcg ttaataatgg 3347641 aatgagcagg ctgaccagcg tggttactac actgagggca agcgcaaagg cgagctttcc 3347701 ataagaagga ttggtccgtc ttactaaggc aaaaaagggt ttcaatttac ttttagattt 3347761 ttgtttcttg gttggcatat attttcctcc tgtttcagcg ttcagaaagg tgaaaagtca 3347821 tagcaaaagg atgattttta ctctttctca atcatatcaa tggagaaaga ctttttcagt 3347881 atatttttgc cgtgatcaaa ataaaaatct cccactcatt gtttgaatag gagatttttg 3347941 tgttagacat ctttcactgg cttctttttt ctgtaagtca atgttacatc ctgctgtcgc 3348001 aggtcttcta ttatcatttt gtaccgatca acttttgcgg tatgttcttc ttttatcatc 3348061 tgaagggcag cttttcgttt ttcgctatta gactcaagct ctttttttat tttttttaca 3348121 atcaaccctt tttgcccttt gatttcctct tttaatgaag actcaaattt ctttgtcagg 3348181 ctgagaaagt cgttgatcgg ttgattgagg gtgcccgctt tccccttcat ttcatcttgg 3348241 gtaagaaaca tataggtcgt tgatacaatt tctgtttcac tttctgaaaa taaggaagtc 3348301 actcttcata ttcctcctaa gactgaaaat caaataactg agaaatcatt tcttcttttt 3348361 caaacagctt ttcaatactc tcgcggatat ttttgataaa atctcttttt tctgttgtct 3348421 gtttttttaa ttcagcaaca attccatcat ttgcaggaag cgcacctgtg tggaatgatt 3348481 catgaactga gattttctcc aatttatcga atgtgtggct gaaaccagct gcaagccgga 3348541 attgaagatc gaaggcataa tgcgaagggt tttcttccat atgatgaata gccgtgatga 3348601 tcgcctgctt tttgtctatg aagtcttcat cgatttcctg actgtaaacc ttctggtact 3348661 tagaaatcgc atcttccata tcttcaacga ttttcatacc gttttgatag attctgacag 3348721 cggatgagag attgacttga atcgtttctc ccgagccact cttccctgta aaataaatat 3348781 cggagccttt atagctgaag cctttttcct ttgacaaggc gttgagcatt tgaacgatgc 3348841 tgtggccgtc gacgataagt tttagtgcgt cttttgtttc tgtgtcgagt gttttcaatg 3348901 aggacagaat tgattttaca tagtccacta tttcaccaac gtcttttaaa gcttgcataa 3348961 attggccatg ttttagatgg tctatgaaat gttcgtaccg tgactctatg cctcgcatac 3349021 tcgcattaat attcgttaat tcttttttga tgactttctt ttgcgtttca tcaatataac 3349081 cattttcagc taactgatct acgaccggtc cgctgtttct caacaaggta tgaagaaaac 3349141 ctaaaaacga cggcagttcc tcttttattc ggccatacat ttgcttaaca tcatcaaaat 3349201 gctcatatag gacacttact ttctttaaag cgccgtctgt gtttttcact ttttcaatca 3349261 ggtctatgtc tatcccgctg gctgccttta taaaaccgtt caagccgtct ttttcatagt 3349321 catccttata tttttgaagg aatttttgaa ttgacctcac atcttcgtca ggaaccccat 3349381 ccataatgtt tcggatgcct tttacacttg tatttgtatc tgccatcttc acatcaccga 3349441 atgtaataaa atcggccttg ccgctgactc catacagcgg gtcatctttt gagatgcgct 3349501 gagtgatgtt tgttgttacg cctttgtctt cataatattt ttggatttct ttttttaact 3349561 tttctggcgg gatggaatct atatcttcat atttataact aaatttccta ataacatatc 3349621 tatataaact ttcatcagtt tcaagtaatt gatcaatatt gacttgagct ccatttaccc 3349681 cataaacttc atcatattct ccatcaatca attgcaccat aacttggtta ttatttgcaa 3349741 gtgaatgtcc taaggcgaat gtttttaaat cctcagagtt acctgctgct ttctttgctt 3349801 tgttagtaaa ctcctttgta gcctcatact gactatgatc aattcctaaa aaaagaccaa 3349861 aaaagttata tgaccaatcc ttattatcgg cactaccttc tgaaataatc tgaagctgat 3349921 caatatgttt tttctcatct attatatgga ttgccgttcc atcgtaacct gattctctgg 3349981 tcgaactttg tatacttgta ttctgattta caagttcatt ggaggtgtaa atttcaattt 3350041 tcatattctc aggaagatcg tggtgggttt cctctttata aattctgcgt atatctgctt 3350101 cgaaatcctt cttagctttc ttaacttcac tcgcaatagt tgaggcaaac ttttgtttat 3350161 agtcatattc taaatcaatt aaccttaact ttacgttctc attctcaaat acatttttat 3350221 ttcccatctt atttctcctt tttatctatt aaaaaggtga tagaattaat taatttctca 3350281 actttatttt tagccttttc ttcatctaag gagcatggtt gattttcatt tttgcatcca 3350341 agggtaaagg cgtattctac tcctaggtta tcttcctctg tagacttaac atatccaaaa 3350401 taactgtatg aataattata ttttctatca atatcgtcaa agatgtcttt tttcttggca 3350461 gtgtaaatat ccgttttctt tttgctgctt tttttgtatt cgcctttata atcatttttt 3350521 ccactaacaa tatctagcat tgtcttaggt tcattcgcaa aactttcttc tttgtaatat 3350581 gttacatggc catcaaacat tacattggtg tctttatcat aactattaaa tccaatactt 3350641 tctttgtttt tcccggttaa cgatgatctt cttgatagat actttccatc ctccggaaac 3350701 aacatcctaa accctttcag cttagattcc agcaaataat atcctggttc ctcttctttt 3350761 gttgacacca tgtactctct cgttttctcg tcctgaaacg caggtacttg aggcagatcc 3350821 ttgggatcca tgtcttttgg ttttaccgct tctgttttat tgtcatttgt gctgttttta 3350881 tcattgtcat tcatactgca tcctcctgtc agggcaagta ataagctgaa gcaaataaag 3350941 atgatctttt tcattacgaa cctccacggg ttttgtgaga atagtattct atttttatat 3351001 caaaaataat tctattgacc tggttaagag atgattattt catccttttt catgttacat 3351061 catggcggaa tttggataaa taggaaatga gactcggttt tgatctcctt ttattaacta 3351121 atcatatata acacccaata taaatctaaa tacctattac ttttttcaca aaacaaaaag 3351181 agccgtatca tccggctctt tactcttcaa tctcagaatg gcgttttttc aatacgtcaa 3351241 gcacatcatc cagcggcagg gattgttctc tgagcaggac aagcaggtga tacagcaggt 3351301 ctgccgcttc ccatttgagt tcctcatgat cccggttttt cgcggcgatg atgacttcgg 3351361 atgcttcttc tccgactttt ttcaaaatct tatcgacgcc ttcacggaag aggtacgtgg 3351421 tgtaagctcc ttcaggcatt tccgcttggc gttccgcgat cacccgctcc agttcgttca 3351481 tgatgccgaa tcggtccgcg gcctgttctt ctgtttgttc ctttgtaaaa cagctgtagc 3351541 tgccagtgtg gcatgccggg cctgacggtt ctacgagtac gagcagcgcg tcttgatcgc 3351601 agtcataccg gatacctttg acggcttgcg tgttccctga ggtttctcct ttatgccata 3351661 acgcttggcg tgagcggctg taaaaccatg tttccttcgt ttccagcgtt ttttcgtacg 3351721 attccttgtt catatacgca agtgtcagca cttctttgct tgccgcatcc tgcacgatag 3351781 caggaattaa tccgtcctcg ttaaaacgca gttcatctgc ctgtttcatc tcacattcac 3351841 cccgtactct ttcaagtatg atttcacttc tttaatcgat gtttctttat aatgaaaaat 3351901 tgaggcggcc agcgcggcgt cggcttctcc ttttgtaaaa gcctcaagca tatgctgtgc 3351961 gtttcccgcg cctcccgaag cgataacagg gacggggaca gcttcggaaa caagctttgt 3352021 cagcgtgtgg tcgaaacctt ttttctcacc gtcggagtcc atgcttgtca gcaatatttc 3352081 tcctgccccg cgtttgacgc cttcttttgc ccacgcggtg acctcccaat ctgttttctt 3352141 tctgccgccg tgcgtgtaga ccttatatgt gtcagattct ttgtcatact tggcatcaat 3352201 ggcaagtacg atgcattgag aaccgaaaaa ctcggctcct tctgtaatca gctcagggcg 3352261 gagaacagct gccgtgttca ccgacacttt gtccgctccg gcacgcagta tcgttttcat 3352321 atcgctgagc tgattgatgc cgccgccgac tgtaaacgga atggcaagct tcgcggcaac 3352381 ctgctccaca acgtcaacca tcgtctttcg tccttcgtgc gaggcggaga tatcaagaaa 3352441 aacaagttca tccgcacctt cccggtcgta cacttcggcg agttcaactg ggtcaccggc 3352501 atccttcaat tcgagaaatt gaattccttt gacaacgcgt ccttctttga catcaaggca 3352561 tgggataatc cgttttgtga tcatttgcgc ttcacccttt caagcgcctc actcagcgta 3352621 aactgattgg tatacagcgc ttttccgatg atcgctccag agacgccgtc cgcctcattg 3352681 cgggcgagag cttcgagatc cgcgacggag ctgactccgc cggaagcgat caccgatttc 3352741 cccgtttcct tagcaagctc gaccgtgctt ttaacattgg ggcctgacag cattccatct 3352801 gtcgcgatgt cagtaaaaat aaagacttcc gcaccttcat tggctagctc tttgcccagt 3352861 tcagttgcct taagggttga tgtttcaagc catccctctg ttgaaacaaa accgtttctc 3352921 gcatccagtc cgattgcaat tttctcgcca tattgtttca gcattttttt gacaaacgga 3352981 gggttagaaa ctgctgagct tcccaggatc acccgctcga ctcctgctga taaatattca 3353041 tagacgtcat tttcagaacg gatcccaccg ccgatttcga ctttcaggtt cagcttttgc 3353101 gcaatctcaa tcacatggcg gtcattcact cttttccctt ctttggcccc gtcgagatca 3353161 acgagatgga tccattcggc accctctttc tcaaataact cagccatgtc gtacggtgaa 3353221 tcgccatata tcgtttcctt attataatcc ccttgaacaa ggcgaacaca tttgccgttt 3353281 ctcatatcaa ttgccggata taatgtaaaa gcactcattt tttcaccttc tgttctgctg 3353341 ccattttcgt aaattgggtt aaaatagaca ttccgaccgt gctgcttttt tccggatgaa 3353401 attgggcgcc gaagacgttt ctttttccga ctacagcagg cactcgtaca ccataatcgg 3353461 cgcttgccag aagcgcgttc tcctccatcc cgtcaatgta ataggaatga acgaagtaag 3353521 cgtagccttg ttctgtttta gtcagcagcg gagattcatt atgaaaagaa agacgattcc 3353581 agcccatatg cggaaccttc agcttgtttc ctttttcatc ttctgctttc agcctgactg 3353641 cttttccttt taacagcccg agtcctgaag cggtgccgtt ttcttcgctt tcttcaaata 3353701 aaagctgcat gccgaggcag atcccgagaa gcagccttcc ctctgagacc atatcgtgaa 3353761 tcaattgatc aagcttcgtg tagcccaaat tgtccatcgc gtctccaaat gaaccgactc 3353821 ccggcaaaat gaaagcatca gcttctttca gctcctccgg cttttcagaa acaaaatacg 3353881 gcacgccgac acgttcaagc gcctttgaga cactgtataa attccccatt ccgtaatcta 3353941 tcacgccgat catttacagc atccctttcg ttgacggtat tcctttaact cgcggatcga 3354001 tcgttgtcgc ttcatcaagc gcacgtccca gtgctttaaa aacggcttca atcatgtggt 3354061 gggtatttgt tccataatga acgatgacgt gcaggttcat tcgagcttcg agcgccagct 3354121 tccacaaaaa ttcatgtaca agctccgtat cgaaagttcc gactttagca gccgggaaat 3354181 cagcgcgcat ttctaagtgc ggccggttgc ttaaatcaat cacaacttga gcaagtgcct 3354241 catccatcgg cacaaacgcc gatccgtagc gtttgattcc ttttttatcg cccaacgctt 3354301 cgagcagcgc ctgccctaag cagatgccga tatcttcagt cgtgtggtga tcatctatat 3354361 caacatcgcc ttttgcgtta atggaaagat caaattggcc gtgtttcgtg aataaatcca 3354421 acatatgtgt cataaacggc acatctgttt taatatccgc ttgtcctccg ccgtctattg 3354481 taaatgccag ctcaatatct gtttcgtttg ttttcctgac gcgttccgct tttctcattt 3354541 agaaatcctc cgttctctcg cttcaattga tctggcatgg gcttctaacc cttccagtct 3354601 ggcaaaagcc gcgatgcttt cggcatgttc ttcaaaggct gattgactgt aagaaataat 3354661 gctcgatttc ttttgaaaat cagttacgtt taatggactt gaaaatctgg ctgttccgtt 3354721 tgtcggaagc acatggttcg gtccggcaaa ataatcaccg acaggctcag ggctgtatct 3354781 gcctaagaaa attgcacccg catgtttgat actgccaagc aaagcttccg gagactgtgt 3354841 tatgatttct aaatgctctg gcgcgagtgt attgacagtc tcaatcgctt ctaccattgt 3354901 ttccgccaca tatatacaac cgtaatctct cactgaagct tccgctattt ctcttcgcgg 3354961 caaggtttcc agctgcttat tcacctcggc tgaaaccgtc tcggccagcg ccatggaatc 3355021 tgtgacaaac acacatgagc taagcttatc gtgttccgcc tgtgacagca gatcggctgc 3355081 aatttcgctc ggaatcgctg tttcatcagc cagcacgacg atttcactcg gtccggcaat 3355141 catatcgata tcgacatcgc cgaacacttc tcgtttggca agcgcgacat aaatgttgcc 3355201 cggacccgtg attttatcca ccggctcaat ggtttctgtt ccgtatgcta acgccgcaat 3355261 cgcctgagcg ccgcccattt tgtaaatgtc ttttatgccc agctcggctg cagcaaccaa 3355321 aactccagga gacagcagac cgtcttttcc cggaggcgtg acgagaacga ttctttcaac 3355381 gcccgctacg agcgccggaa tcacattcat caaaacagat gaaggatatg cggccgttcc 3355441 ccccggcaca tatacaccgg cggaatccag cgccgtcact ttctgcccca gcattgtgcc 3355501 gtcctttctg tgataaaacc aggaggattg cagctgtctt tcgtgatatt ccctaatatt 3355561 ttcgattgcc tgcctaatca cctgaagaag acgtgaatcc agtgaggtgt atgcctcctc 3355621 aaattcttct tttgtgacca gcgggctgtc tatttcgatg cagtcaaatt tcgccgtgta 3355681 gctgcgaacc gcctgatcac cgtttgcttt aacatcttca ataatggacc ggaccgtctt 3355741 tctttgctct tccgttccgg catcgatgga acgcttgaga gaaagccgtt ccgctccgct 3355801 gatggttttg atcttcattt tgccgtctct ccttccacaa cgagagatag gcgggatgcc 3355861 atttcgtcaa tcacatcgtc tttcatgcga tagcttaccg ggttgacaat aaagcgagag 3355921 gtaatgtcac aaatgtgctc cgtttcaaca agcccatttt ctttcagcgt ctgtcctgtg 3355981 gaaacaatgt ccactatccg atctgcaagc ccaatgagcg gagccagttc aattgaaccg 3356041 ttgagcttaa taatctcgac ttgttctccc tgctctctga aataactgga agccacattc 3356101 ggatactttg tcgcgattct tggcgctact ccgctccagt ctgtattcgg aagtccggcg 3356161 acagctaagt ggcatttgct gatgtttaaa tccagtacct catacacatc gcgttcctcc 3356221 tccagcatga catccttgcc cgcaattccg acgtctgcca cgccatgctc cacatacgtg 3356281 gttacgtcca tcggcttcgc taatataaac cgaagatttt cctccggcac atcgatgatc 3356341 agttttctcg aatcttcaaa ctcctcaggg agcctgtagc ctgcctgcct cagcagccct 3356401 gccgcttctt caaatatccg gccctttggc atcgccattg tgagtaactt acccattttg 3356461 ctcttccttt ctggcaccga taaaataagt gacgtttgca aaagattttg tcatctggtc 3356521 gatattttct attcccgata aatcttgaag aaccactttg ttccctttca tgcgttcttc 3356581 attcgcataa gcgatggctt gcgcccgctg ctctttgctg aaaataacag cgtctatttc 3356641 acaaggttcg tccttcatat gaagggcttc aatcagccgg tcgatccgaa gcccgaagcc 3356701 tgttgccggt gcaggtgaat caaaatggcc cagcagcttg ttgtaacggc cgccgcttcc 3356761 aatgacaaaa ccgacattct cggcgtacac ttcaaataaa atccctgtgt aatagctcat 3356821 gtggctgacc atattcagat ccaggcggac attttccgta catccgtaat cctcaagaat 3356881 gtcccacagc gccttcagct catcaaccac gctttttcct tgcgcagaat cgacgatttc 3356941 ctcggcacgt ccgcatactt ctataccgcc ccgcagttca aggagctcaa gcagcctgct 3357001 tttatcaatg gaggaaagcg ggagagactt gacatgctct ctgtagccga cgtagttctt 3357061 ttcatataag aacctccgca gcacatcagc tcgttcaacg tttccgagca cctcaacaaa 3357121 caaagcatcc gcaatgccgg catggccaat tgcaatttta aaggatgcca gcccagcgtt 3357181 ttttaatgcc ccgacgacta aagcaatgac ctccgcatcc gcgctcgtcg tgccgtcacc 3357241 gattaactcc actccgacct gctcgaactc agccggacgt ccgccttcac gctcctgagc 3357301 cctgaataca tttgccgcat agccgactct tagcggatga ccgtgtttca gaagcttcga 3357361 tgccgccacc cttgcaatcg gccccgtcat atccgggcga agcaccaatg tcttgccgtc 3357421 ctgatcaagt agcttaaaca gctgctgctc ttcaattgct gactggacgc caacggtatc 3357481 gtaaaactcc agtgtcggcg tttccataaa ttgatatccc catttatcaa tcaaatcggt 3357541 taacgatcgt ctcacctttt ttttcgtttc gtataaaccg ggcagtgtat ctctcatgcc 3357601 gtgcggtttt tcaaacataa acatcaaccc gagcacctcc gctgttatct tatgaaggaa 3357661 aattccgaat cctttagttc gctaatatga taatatgtta gcagatgaaa gaatgaaaat 3357721 caacgcttaa cttcagtaag gatattttta gttcaaatat ccttctcctc attatgaaaa 3357781 aatcatgaat aatgtattaa aggtacgtaa tatctcaaat tctttatgtt tggcatgcta 3357841 taatacaaat caaatagaga acaaggagat aaagatgaaa acactgcgaa ctctatgtgt 3357901 cctgatgatt ctttcaggcg ttattttttt cggacttaaa atagatgcaa aagatataga 3357961 tattcctttt ttgaacagcc ttaaaaaagt ggtttctgat agcgatacag actcagctgc 3358021 gaatagcaaa aaggagctga agggaagcgc aaaaccgctg gatgtcatcc tttacaatca 3358081 aatggacgca ccccggctct ataacggctg tgaagtaaca agccttgcga tggtgctgaa 3358141 ttatgcggga tacgacgtga caaaaaatac cctggcaaat caggttgcca cagtgccttt 3358201 gacatacagc agcggattaa agggtgatcc gaatgacgga tttgtcgggg atatggcgaa 3358261 tggccctggt ctcggtgtct accatcgacc gatctatcag ctggcgaaaa cctatgcggg 3358321 agacaaagtg tctgatctga ctggaaaaag tatttccgct gtttatcagc agcttgaaaa 3358381 aggcaatcca gtttgggtta ttacgacagc caactttacg ccagttgaca acatgcagac 3358441 atggaaaacg ccaaacggaa cgatagaaat tacgtacagc gaacacagcg tcgccgttac 3358501 gggatatgat gataaatatg tgtatctcaa tgatccgtat ggctataaaa acagaaaaac 3358561 cgatagaaca agctttgaaa aagcgtggaa acaaatgggc agccaggccg tggttattca 3358621 aaagtaaaca cctgaagcct cactatgctc tattctgagc aaatacgaca atattcatgc 3358681 tttttgtatc aatcggtaag atcgattcat tttccatttt tcacccaaaa ttgtctttac 3358741 tttcaggctg tctgttttta tgattaaagc agattcagcc ttgccccgat ctatgcgaga 3358801 gaagccggtg caagtcgctg acgcttctct tgcaaaaaat gaaagatatc cggggaggat 3358861 ttatcattga aaaaaatcgt gtctatccta tttatgttcg gtttggttat gggtttcagc 3358921 cagtttcagc catcaaccgt ttttgcagct gacaaagtgg tgcacgaaac aattatcgta 3358981 ccaaaaaata caacatatga cgggaaagga cagcggtttg tggcagggaa agaattaggt 3359041 gacggaagcc agtcagaaaa ccaagaccct gtttttcgtg tggaggatgg agcaaccctg 3359101 aaaaatgtgg tgcttggtgc acctgcagct gatggcgtgc acacttatgg aaacgttaac 3359161 attcagaatg tgaaatggga agatgttggt gaggatgcgt taacggtgaa gaaggaagga 3359221 aaagtgacga tcgacggcgg ttctgctcaa aaagcgtcag ataagatatt ccaaatcaat 3359281 aaagccagta ccttcacagt gaaaaatttc acggcggata atggcgggaa gttcattaga 3359341 cagcttggtg gttcaacctt ccacgttgat gtgatcatcg acaagtgcac catcacaaac 3359401 atgaaggaag cgatattccg gacggacagc aaaacaagca cggtcagaat gacaaataca 3359461 cgctactcta atgtcggtca aaaatggatt ggtgttcagc atatttacga aaacaacaac 3359521 actcaatttt aacaaaaaaa gtccgctgat gttattcagc ggactttttc aatctttctt 3359581 gcatttcttc cttcgtatag atgatcctca tcggatttcc gccgacaaat gccccgtcag 3359641 gcacatcctt atggacaagc gttccggcgg acacaactgc gccatctcct attttcaccc 3359701 cgggcagaat ggtcgtgttg gcaccaatca tcacttcgtc cccgatcaga actttgccga 3359761 tccggtattc gtgaatcaaa tactcatggg ccagaatggt cgtattgtac ccgatgattg 3359821 tatttgttcc gactgagatc ttttccggaa acatgatatc tggcatcacc atgagggcaa 3359881 aggatgtctg ttttccaacc ttcatccgca gaaatgtgcg gtacagccag tttttcatcc 3359941 ctataaacgg cgtatatctc gcaatttgaa tgacaatgaa atttttgacg acctttaaaa 3360001 aaggtaccgt ttgatagaca tgccacagtg agttggcccc cgagaccgga tgacgatctg 3360061 tttttctcac agattacttc actccaacga tttgtaatag atcactcatt ttctcaagca 3360121 taaaatccgg ctcatgcttc gccagcattt ccggcccttt aatcgtccat gcgactcctg 3360181 ccgtttttgt accggcgttt ttccctgcca gcacatcatg gtaattatca ccgaccataa 3360241 tggcttccgc cggctcgctt cctagctgtt tcagcgctaa cagcacaggc tcgggatcag 3360301 gctttgcatt cgtcacatca tcaagggtga caactgtttc aaagaattcg ccgattcccg 3360361 tgagcttgag gcccatattg acagtatctc ttaattttgt tgtcacaatt cctaatgtaa 3360421 agccggcttt ttttaatgca tccagggtct catataccgt ttcatattca gtgacgagtg 3360481 aatcatgcat gtcatgattg tacgctctgt acatagcgat catatcctcg catttatcag 3360541 ggtccatcga agagaacgta tcaaaaagag acggcccgat aaatgcaagg acatcttctc 3360601 gtttatactt gctcggataa taatgctcca gtgtatgcaa aaaggacgcg ataattaatt 3360661 cattcgtatt aataagcgtt ccgtctaaat caaacagaat cgtcgttact tgtttgtcac 3360721 tcatattgct tcctttccaa ccgctgaggg tttccatttt ttccacgtgt gcgcaatagc 3360781 cattgtcagc agaactgctg tggtgacacg aatcaaaaga agcggccaga ccggtatgcc 3360841 aagcggaata aagacaagtg tatcttccac gaccgcgtgg caggcaacga gaaatataaa 3360901 tgccaatgtc atgtcccgct tgctcacgcc gtcatcctcg acagctttga tcatgacacc 3360961 cgctccgtag gccagaccaa tcgtcagtcc cgtcaccatc gtcatagacg tatttttatt 3361021 catgccaagc agctgcgtaa acggcgacag ccacctggaa aaccgataaa gccagcctaa 3361081 atctcttaaa aactggatga taatcatcag cgggatcact attgccgcca gctgcaaaac 3361141 accaagtccg gctttcgtta atgcttctgc caacattcct agccagctgt ctggcgccgc 3361201 gctcttcgca gcgataaaac cgtactgcgc cgtttccttt ccgccatgcc aaatgaggtt 3361261 gatgacgatg gctgacacag cggccaaacc gatgcgcacg gccaatatga cgccaattct 3361321 gataccaacc tttgcggcaa ctgtcgattc gataatcaag ttatgacaga aagaaagcat 3361381 aacagctaaa ataaagactt ctttcacaga taaatccaat gttaaaatcc cggcaattcc 3361441 cgcatacaga ttcagcatat ttcccagtac aagcggaatg gccgcttcac cagaaagccc 3361501 gaagagaccc attaccggtg tgatcagccg tacaagccaa tccatgacag gggtatgctg 3361561 gagcaaagtg accaatagcg ttaccgggaa aatcacttta cccagcgtcc atgttgtttg 3361621 aaaacctgct gcaagaccgg ccagaaagat cttcttcatc cctcatcccc ctttgttgac 3361681 gtctactccg cgtaccgctc cttcgagtat cccttgacgc gtctgaagat gatggctgcc 3361741 acagccaaaa caatcaatac gattgaaatc acctgagcga tgcgaagtga atcagtcagc 3361801 attaagctgt cagtccgcat tccttcaata aagtatcttc cgattgaata ccaaatgata 3361861 tagatcaaga acatctcgcc tctacgcaaa ttcgctctgc gcagcagcag taaaacaatg 3361921 acgccgacaa agctccatag tgattcatat aaaaaagtag gatgataata ttgcccattg 3361981 atatacattt gattgatgat aaattcaggc aggtgcaggt tttctaaaaa ggctctgctg 3362041 acagcctcgc cgtgcgcttc ctgattcatg aagttccccc agcggccgat cgcctggccg 3362101 agcaaaatgc tgggcgcggc aatatccgca agcttccaga acgaaaggtt tttcactctc 3362161 gaaaacacat aacccgttaa aatggcgccg attaatccgc catgaatggc aatgccgccc 3362221 ttccaaatct taatgatttc tcccggatgt gccgcataat agtcccattc aaaggcaaca 3362281 taataaattc gtgcgcaaat aatcgcaatt ggaatggcaa acaggacaag atcaataaac 3362341 gtatctttct gcagcccccg tttttcactt tccctcatcg ctatccacag cccgagcaaa 3362401 gcgccgagac cgataatgat tccgtaccag tggacggcta acggccccag ctgaaatgct 3362461 atcggattga gtggttctat cgcttcattc atttaacgcc aactcctatt cttcttgttc 3362521 accgtcttca atgacgtccg ccagcttgtt ggtaaattgt tcagcggcat tcagccccat 3362581 ccgcttcaat ctgaagttca ttgctgccac ttcgatgatg actgcaagat ttcggcctgg 3362641 gcggacggga atcgtcagtt ttgtaatttc tgtatcaatg attttcatgg tctcttcctc 3362701 aagtccgagc cggtcgtatt gcttgccctg ctcccagagt tcaagattca tgacaatcgt 3362761 gattcgttta ttgcttctga ccgcgccagc gccaaatagc gtcatcacat tgataatgcc 3362821 aaggcccctg atctcaagaa ggtgctcaat taattccgga gcgtttccca caagagtatc 3362881 ctgatcctcc tgccgtattt caacgcaatc atcggcaaca aggcgatgcc ctcttttcac 3362941 aagctctagc gctgtttcgc tttttccgac gccgcttttt cctgtgatca gcacgccgac 3363001 accatatata tcgacaagaa cgccatgaat tgctgtggta ggcgccagcc tgctctcaag 3363061 gaagttggtt aaacggcttg acagtcttgt cgttttcagc ggcgatctga ggacaggcac 3363121 cccatttttc tcggaggcgt caatcagctc ctgcgggatg ggcatatctc tagaaagaat 3363181 aatagctggt gttacatcag tgcacagaga atccattcgc tgctttttct cctcttcagg 3363241 aagctgttca aagaaagaaa gctctgtttt tccgagaagc tgcacgcgct ccctcgggta 3363301 atatgtaaaa tatccggcaa tttcaatacc tggtcttgat aggtcactca ttgtaatcgg 3363361 gcggttaatt ccttcttctc cgctgattaa ttccaaattg aactgttcca ttacgtcttt 3363421 tgtgcgaacc tttgccacga tatgttcctc ctgttccggg ctgccccgag cttgctcaca 3363481 atactttcat tttatcactt tcgggcttga acctaaaaca gattttataa aaggggggaa 3363541 aacacctcag ctggtctaga tcactagtct gaaaaagagt aaaataaagg tattcaaatt 3363601 ccagaaaggc ggatcatcta tggcagagag tcttcttatc aaagacattg cgatcgtgac 3363661 agaaaatgaa gtaatcaaaa acggctatgt cggaatcaat gacggaaaaa tcagcacagt 3363721 ttcaacagaa cggcccaagg agccatattc aaaagagatt caagcacctg cggattccgt 3363781 tttgcttccc ggcatgattg acattcatat ccacggcggc tatggcgcag atacaatgga 3363841 tgctagcttt tccacgctcg acatcatgtc gtcaagactg cccgaagaag gcacgacgag 3363901 ctttttagcc acaacgatta cccaagagca tgggaacatt tctcaagctt tggtgaacgc 3363961 aagagagtgg aaagcggctg aagagtcctc tttattaggt gcagaactgc tcggcattca 3364021 tttagagggc ccctttgttt cgcctaaaag agccggagcg cagccaaagg agtggattag 3364081 gccttcggat gttgagcttt tcaaaaagtg gcagcaggag gcgggcggac tgatcaaaat 3364141 tgttacactt gcgccggagg aggatcagca ttttgaactg atccgccatt tgaaagacga 3364201 atcgattatc gcatccatgg ggcacacgga tgccgattcc gcattgctgt cggatgccgc 3364261 aaaagcaggg gcgagccata tgactcatct gtacaacgcg atgagcccgt ttcatcaccg 3364321 agagcccgga gtgatcggaa cggcgctggc ccatgatggg tttgtgacag agcttatcgc 3364381 cgatggcatt cactcccatc ctttagctgc aaagcttgct tttttggcga aaggcagcag 3364441 caagctcatt ttaattaccg attccatgag ggcaaaagga ctgaaagacg gcgtatatga 3364501 gttcggcggc caaagtgtga cggtaagagg acgaacagca cttctttcag acggaaccct 3364561 tgccggttcg atcctcaaaa tgaacgaagg cgcacggcat atgcgtgagt ttacaaattg 3364621 ctcttggacg gatatagcta atataacttc tgaaaacgcg gccaaacagc tgggcatctt 3364681 tgaccgaaaa ggcagtgtga ctgtgggaaa agatgcagat ttggtgattg tcagcagtga 3364741 ttgcgaggtg attctcacca tttgccgcgg aaacattgca tttatatcca aggaggctga 3364801 ccagatatga aagtaatgga atgtcaaacg tatgaagagc taagccaaat agcagccaga 3364861 ataacggcag atacaatcaa agaaaaacct gatgctgttc tcggtttagc gacgggcggc 3364921 acaccggaag gcacgtatcg ccagctgatc cgcctgcacc aaactgagaa tctctcattt 3364981 caaaacatca ctacagttaa tttggatgag tacgccggac tttcaagcga tgacccgaac 3365041 agctatcact tctatatgaa cgaccgtttt tttcagcata tcgacagcaa gcctagccgg 3365101 cattttattc cgaatggaaa tgcagacgat ttggaggccg aatgcagacg gtatgaacag 3365161 ctagtcgatt ccctcggcga cactgacatt cagcttctcg gcatcggccg aaacggacac 3365221 atcggcttta acgaaccggg aacgtctttc aagtcgcgaa ctcatgttgt gacattaaat 3365281 gagcaaaccc gccaagcgaa tgccagatat tttccctcca tagacagcgt gccgaaaaaa 3365341 gcactgacaa tgggaattca aacgatactc tcaagcaagc gcattctgct gcttatttct 3365401 ggaaaaagca aagcggaagc tgttcgtaag ctgttagaag gaaacataag cgaagatttt 3365461 cccgcatctg ctttgcacct gcattccgat gttacggttt tgattgatcg tgaagccgcg 3365521 tcattaagac cttgaaagga acatgctgac ttatgaatat caataaacaa tcgcctattc 3365581 cgatttacta tcagattatg gagcaattaa aaacccaaat taagaacgga gagctgcagc 3365641 cggatatgcc tcttccttct gagcgcgaat atgccgaaca attcgggatc agccggatga 3365701 cagttcgcca ggcgctttct aatttagtta atgaaggctt gctctatcgc ctgaaagggc 3365761 ggggcacctt tgtcagcaag ccaaaaatgg aacaagcact tcaagggctg acaagcttta 3365821 ccgaggatat gaaaagccgc gggatgacac cgggcagcag gctcattgat tatcagctta 3365881 ttgattcaac tgaggagctc gcggctatat taggctgcgg gcacccctcc tctatccata 3365941 aaatcactcg ggtgcggctg gcaaatgata ttccgatggc gattgagtcc tcacatattc 3366001 cgtttgagct tgcgggtgaa ttgaacgaat cgcattttca gtcgtcgatc tatgatcata 3366061 ttgaaaggta caacagcata ccgatttccc gtgcaaaaca ggagcttgag ccaagcgctg 3366121 ccaccacgga agaagcgaat attcttggta ttcaaaaggg agcgcctgtc ctattaatta 3366181 aacgaacaac atatctgcag aacggaactg cttttgagca tgcaaaatcc gtatacagag 3366241 gcgaccgtta tacatttgtc cactatatgg atcgtctttc ataaaaaaag cctccaaccc 3366301 tttttaagga ttggagacat ggcgaaaatc aaactggtct ggtgccggac gatatgtttc 3366361 ttttttcgtc ttgaacttcc agatcggtga tttcgttttg ccgttaaaac tgtcttccac 3366421 tataatgtac caataataaa cagactgcgg ttcaagatga tcccagcgga attcagctgt 3366481 gtccccgctc ttcacttgct cccgttttcc gagctcttca ttggtatata cgttacattc 3366541 aaaataatcg gtttccacct ttttgattct tggcttcaaa tcaagcgaaa gggaaaattc 3366601 atccttgttg ccataggtat ccgtatcata gtagttctta tcctttacat acggagagta 3366661 cgtcgatacg tgcaccatgt cattggcttg gtcaaattga agcaaacgca aatacccttg 3366721 gccgccttct ggcccgccct gataatcggc cagcatttga tgcacaagac gatccggttt 3366781 cccatcacca tcatcatcca gctcatctgt ttttctcatc gcactatgat aatgcccgct 3366841 caacaccatc acgacattcg ggttcggctt tacgatttct ttgaatattt tctctccgat 3366901 tgggcttctg tttccgctga ccagcaaata ctcatgaaaa gctaaaatgg ccatccggtc 3366961 aggatgcttc ttcagcacct gattcatcca cgcgatgtct tcatccgtaa tgccccatcc 3367021 catgtacagc atgatataat cattgccgtt gctagaaatc aggtcataat gtccgcggtt 3367081 atttttatag gaaccgccat aatgaaattt tttatcaaaa cgatcgctgc caaaatattt 3367141 gccaaacgcc ctgtaggagc cgtccttatg tccgacatcg tgattgccgg ccagcacgcc 3367201 gtaaggaatt ccgctcttat ccagaacgga cattgaccga tcagcgtttt tccactgtct 3367261 gatatcggcg gaatcatcta caatatcacc cgtgtggaac acatatttga tattgagctg 3367321 cttttgatta tcttttatcc attcggtctg tttatcaaaa atatgcggat agctttcggc 3367381 gtaatactgt gtatcagaca tccagacaaa tgtgtacata tccttcgcag gaggaatttc 3367441 atcctgtaca atcacattca ttttcgactc ccgtacaaaa tcggcggcaa tcacagacgc 3367501 tttcagcgta aacggtttgt catccttcgc gacgaagctg tcaacaggct gccattcgtt 3367561 tgtccgataa ttccaagcat acatcgtcac ctttctcccc ggcaaagaac tgcccttcca 3367621 gactgattct gccagatcat tctcatcaat tgatggatca accgtcactt caaagcgatg 3367681 ataagggaaa agctctttgt tttctgtcga tactgttttt ccatcagcag ctgatacccg 3367741 ctccaattct ttattcgtaa atggggtctc cctttccggc acaaagcttt tcggcggttc 3367801 agtcagtgac gcgtgcttaa atattttcac atgattgcgc gctgtatatt gaaatcccct 3367861 ataaaaacca acatccatgg catcattcgt cggatctttc acccgtacag aaagcttggc 3367921 cttatgcgtg tcggcttcgc tgtctataac ctccggctgg tccggatgct ctcgttcggt 3367981 tttaaatatc ctctcaatca ctgttttatt gcccgcgaga tccgttgctg tcacttttag 3368041 agaatgtttt cccggcaaaa ggtcagaaga tgacgtatga tatgggagtg taatgctttc 3368101 tccatctaac gacgcctccg cttcctcaat tctgctccat ttatcataca tatccgcctg 3368161 caggataagg tttcctttat acgtttgccc ctcggtgata ttcggctcaa tgtgaggtcc 3368221 tgaattatct acccgtacaa ccaggctgac attttccttc ccgtcgcttg cttgaatatg 3368281 gtgagcgcct tcagaaagct ttgatgtatc ccactccagc agctgtgatg taaatagtcc 3368341 gtcaggcaga ttgaactgaa attgccagct tttattcgag cgctgattat cgccaataaa 3368401 gagttccttc tcaggagaca ccctctgatc tctgatcacc gttccatccg ataacaccaa 3368461 tcgggcgttt ttgactaaga agtcatcacg gttttcagcc gtatcaaacg gagacacctt 3368521 cgaacctgaa cgtatcgtaa tacgctgcag ctgcttccct ttccgaagca gtgtctctgg 3368581 caatggaaca gaataggtgc ggtatttatt tgttgtatca tcgaacacct tcagcacttt 3368641 gccttccatc gttaccgcgt ttttaaaata aaggttcgtt ttcctcgtat cgaatgcaaa 3368701 atatacttct ttttccatcg cgggctctgt cacttgtttt ttcccgtcaa tccatagctt 3368761 aatgctgtca gctcgccctt ctgtcgtggc tttgagaaat tgagttcccg acagcgtgtc 3368821 tctgttttca atattcatcc gcagaccgtg cgccttgctt gtttgtttaa tatcaatcat 3368881 tttgaccggc gttctcgctt cattgatccc gtccccggcc gccacataat actctagctg 3368941 atccttcccg atcaattcag gcgaatacac aatataatgg aagagattat cgttgcggtc 3369001 tttttcagca agaattcgct taaacggttt gttctcatcc gtccggtagt aaaaggccac 3369061 tgttttcact aggcttcggt cccgtatgtc agcccgcagc tcaatgcttt cagcagggcg 3369121 gacaggcttg cggtcagtca aatcctcaat gaccggcttt tctttatcga gcttgatttt 3369181 ccgtttctgg tcgggcacct gtgcctgtaa tacggttccg ggagacggat tcttttcccc 3369241 gattgaaatg ttcagaagtt ctgctgttcc gttcagtgga tacttataaa gcactgatga 3369301 cagccggcgc agcgcatgtt tccgataatg cgcaaccgaa atgtcctttc ctgtattcgt 3369361 tgatatcaca acggcccgcg gcctcgtatt ggccataccc tctgtctcgt ctatcaccgc 3369421 aagatttttt ccttctttta gttgtgtctg ataataacga ttgaaatccg ctgacgtcaa 3369481 ttctggatgc ccggcaggct tcagccagac gacaaacgtt tcgccggatg gtatcaagat 3369541 cctttcatca ggtctccaaa tcagatcgga gtcaggccct tcttttgggt agcggtaacg 3369601 gatatggtag tctttaaaat caatcgttct gtcagtcgta ttaaaaatct caataaattc 3369661 ataaccgtct gcgcgtccta tattcttcgt atcaaccgcc agctctgtga tcagaagctc 3369721 cggaatatgg gcaaggtcag cctggtatcc ttcaagcttc agtttcttcg tctccgactc 3369781 aacccgctgc ttcccattcg acatcacaat gtaatactca agctcgctgt tccaaatcaa 3369841 acgtttcgga atttgtgcca aaaacttgcg gaccgctccg ggggtcgggt ccatcggcac 3369901 cattttgtag cccagctcat tactttgttt ataaaaaaga aaggcggaaa atgcttgata 3369961 cgaattatcg cgaacttgag cctcaatcat tagattgctt ctcatttcag ctttcacatc 3370021 aatttgagga ggattttcaa gcaagggtat gtaatgaggc gtttgaaata gttcctgctg 3370081 tacaacagga aaagctttcg attcatgatg gccgccagac aaaacggaaa gaaaagacag 3370141 taatatagaa gcaataaccg tgtatttcct catcaaagca cctccctttt catgtatttt 3370201 gcgtctgaac agggaagctt atgagttcat ttttgtgcat aaagaacaaa aaaacgtctg 3370261 tctcttgaaa attccactat tacccagtaa actaaggata gttaaccagt taacaattaa 3370321 atcagagagg caaattgatg gacaacagca ttcatgatga attatttcaa gctatacaac 3370381 aattcgcatt aaaaagggat aaacgcgtct ggcaaaaggt gcagatacca tccattggca 3370441 tatcctcaca acatcacgat cacctcaaaa aagactggac tttgacccag cttcacattg 3370501 tttcctgcat acataccagc caaaatgtga acaacagctt cttagcatcc cgtttacaca 3370561 tctcaaaagc cgctgtttca aaagcggttc atgctttgtt gaaacacaat atcattacag 3370621 tgacaaaaaa gcctggcaac aaaaaagaaa ttttttatac gctaactgat agcggcagaa 3370681 aattggcggc attacatgaa cagcttcatg agaaagcaaa ggagcaatat aaacagcttt 3370741 tcaatgaatt ttcaattgat gatttaaaaa cagtgactgc gtttttcaac ttgtggatca 3370801 aatatatgta aaaagagtct cacccgcatg ggagagacct ttggaattct attatgcccc 3370861 gtcaaacgca acgagaagtg aaacaggtcc gcgtgtatac agaccggact cagcataaca 3370921 aaaatcttcc tctaatctga tattccgcat cttatccagc acaatattag ctacaatttc 3370981 gatttcgttt ttggcaaaag ctgctcctac acagttatga atgccggatc cgaaagcgag 3371041 atgccgggcg gcgccgctaa aagcgctctt gataccaaga tcttcccgat gaatattaaa 3371101 cacgtcaggc tgttcaaatg cttcagggtc ccggttagcc gcaccgatca tacaaaaaac 3371161 aatcgtatct tttttgattt ccataccgcc gaccactgta tcttgggaca gctgccgcgg 3371221 aatcagctga accggcggtt tataacgcaa tgtctccgca atggctctcg gaactaacga 3371281 acggtcagcc aaaacatcat tcatctgctc aggattgttg agcaaatggt agatcatcag 3371341 tgccagcgtc ttatcagccg gttccgttgc ggctaacagc acattaagaa tcagtgcgag 3371401 tatatccttg tccgacagcg ccatgccttc atattcagaa gtacatagga tcgaaattaa 3371461 atctgatccc ggattgacgc gacgttcttt aatgaccggc atcaagtatt gggaaagctg 3371521 ttcgctgcac cataacgaat gtgcccgcgc ttcaggagat tgagagatac tcgtgataaa 3371581 atcggcaact ccgctgtgcc actcagagat tttttcatgg tctcttttat ccagcccgag 3371641 catgtccatc gtgacgcaca ccgcaaacgt ctttccaaaa tcattgacga gatcactttt 3371701 ccctctttca agataaggcg ctaacaagtt ttctgcattt tgtttaatca atggagacag 3371761 atgatccagt gcgtcaccga taaagcttct cactacaatt cttcttttgg cagagtgttc 3371821 ttttccatgc atttgggcca gcacagggcc tcgcatgact ggttcggcac gctcaacaag 3371881 tgatttcgtc gtgaagatat ccggatgctg aaggatatag cggacatcat gatagcggct 3371941 gataaaataa ctgtctatcg actcttcata atgaaccgga tcttcctccc gcagttgtga 3372001 aaaataagca tatggattgt tttgaaattg atcagaaagc acactaaaca atttaatcga 3372061 ttggctcatg ttttactccc cctatcatcc ttcagatgtg atccgtttct cagaaagcat 3372121 ctgcgccatt tcctgtacaa tgagataccc ttgattcggc cgcatacaaa tagaaaattc 3372181 atggttactg atcttctcac ccagcttcca cggacgatga taagcaagga gtgtctcttc 3372241 cacctctaaa atatccggag ctccgataaa aaacggcagc tcagctatga catattccac 3372301 agccaaattc agcatatcct cactgacttc ttccatcatc aaactgacgc cccgcgcacg 3372361 cccgattatc gcttcacgag acatgtccaa acaagcatgt cgaaaatgag gctgctcaaa 3372421 aaatgcatgt tcaacttctt gtctcaacag ctggtaggct ttgttatcta taaaatcaga 3372481 aaatgtatga atcgccttcg gatccccgcc atgagccaca agggctcttt ctgcaaatct 3372541 cctgtttcgt gatacctctt tccttacttt tcgttcagcc tttcctctcg gagttccaag 3372601 cgcttctaga agattagccg cctcatgccc tgcaagtaaa actgaaacgc ttttaaattg 3372661 agctttcgcc catccaatta atctgtaaat ataatcctct gaaaacctgc tgttaaatgg 3372721 gctgatcccc accaaaacat gcctgcgccg ttcaaatatt tctctgcagt tttctgttaa 3372781 tgcctcagca ataaaatgca cagaccttct ttccgttacc attccggtca tctcattcac 3372841 ccctaaaact tatcccgctt taagtcatca ccctcaaata caagatggaa tagctagaac 3372901 aactgaacaa gacgaatggc aggcatcact taaagtttcc aaatgttttt taagatttta 3372961 ataatcattt tcaataccca tatcatgata aatgtttact agtaaacatt agtcatttta 3373021 tcccttttcc ttccaaacgt caatatgatc tgtgcccaaa tatttgaaaa taaatgtaaa 3373081 catcacattt tccacacact ttttacacgc atattcagca tgacatatca acaaatagtc 3373141 taaacaccaa caattgacaa cgaaaacaag aaaagataaa ataaaattgt tcaccagtaa 3373201 acgatttgtt ttattgtttc atcgtaaact attattccta agaaagaagg tagcctatgt 3373261 ctgatttgac aaaacagatg atatacgaca tatacgtgag actgctgcac cttaatgaac 3373321 aaaaagcgaa cacttcactt cagcaatttt ttaaggaggc cgcagaagag gatgtagctg 3373381 aaattcccaa aaatatgaca agcattcacg tcattgactg catcggccag catgaaccca 3373441 ttaataatgc cggaattgcc agaaaaatga acttatcgaa agcgaatgta acgaaaatca 3373501 gcacaaaact gatcaaggaa gaattcatta acagctatca gctgacagat aacaaaaaag 3373561 aagtttattt taaattaacc cgtaaaggca gacggatttt cgacttacat gagaaactgc 3373621 ataaaaaaaa ggagctggct ttttaccaat tcctcgattc attttcacaa gaagaacaaa 3373681 aggctgtatt gaagtttcta gagcagttga cgtcaacact tgaagcagaa caaaccgatg 3373741 ggactccaga caaacctgta aagtaaacaa aaaggcggtg tacactttgg ctcatacaaa 3373801 atcaaaggca gtattgatct tatacactgt ttgcttcagt gcattttttg catctttaag 3373861 ccagaacatt tattcaccta ttcttccgat cattaaagaa tcattccatg tttccacagc 3373921 tatggtgaac ctgtcagtct cagtttttat gattgtgaca gcaataatgc aaattatatt 3373981 aggagcgatc attgatttta aaggcgctcg gatcgtcttg attaccggta ttctggcaac 3374041 ggcagcagcc agcatcggct gtgcggtgac tactgacttt accttgtttc tgatattcag 3374101 aatgatacag gcagccggtt ccgcagcact gcctcttatt gctgccacaa cgatcggaca 3374161 gctgtttaca ggaaatgaac gcgggagtgc aatgggaacg tatcaaatgc tcctgtctgt 3374221 cgcaccggct attgctccag ttctaggagg attcataggc ggagcagccg gatacgaagg 3374281 gattttttgg atacttgcgg ccatctctat cgttttgctg gtgacaaaca gcatcacctt 3374341 tcctaaagat tctccaactg aatctatgca gcaagccaaa ggcaatgtgt tcgctcatta 3374401 taaatcaata tttacaaatc gaacagggaa cgtcattttg actttaagtt ttgttctctt 3374461 tttcatttat tttgcagtaa ttgtctacct cccaatattg ctgacagagc attaccatat 3374521 agatgtgggt atagcaggac tgttatattt gccgctggcg ctgagcacga ttgcaggtac 3374581 gtttctgttt aaaagaatac aggcaaaaat cgggctgcac accttgttta tcggaagcaa 3374641 tgtgattgcc gcctgcagca tcattttatt tgctgttaca cattccgttt ctctcgttct 3374701 catggctctg acgctggcac tgtttggcat ctcgatgggg gttattcctc ccttgtactc 3374761 tacaatgatt actaatgaat ttgagcacaa cagagggagt gcaatcggaa tgtttaactt 3374821 tatccgatat acaggcatgg cagcaggtcc gatggtatct gcctacttgc tcacaatgat 3374881 gccgtctgcc atgtccttta gcctcctagg ccttggattt gccgcattga gcttttgcct 3374941 tcttccgcca atgttttcgc cgcagaagcg cacgaaacaa aaaaagcacc acatgtaaaa 3375001 aagctgcctt tgcgggcagc tttttttatt tttttctaag cggctctaaa atgccttttt 3375061 gaatcagcaa atggaagacc gacaggataa cggatgccca tatcgctgtg ccgaagccgt 3375121 cgatttgaaa gctgtcaccc ataatggacg cggtcatcat aagcgtgatg gcgttaatca 3375181 caaacaagaa gagtccaagc gtcaccatgg tgaccggcag tgtaaatata attaaaagcg 3375241 gtttaatcag cacgtttaag atcgataaaa tgaggctggc gataatcgct gccccaatgc 3375301 tgctgatatg gatggagtca atatatccat caatgacgat taataacaat gcattgacta 3375361 aaatgctgac tgcccatttt accatgtcat ttcatatccc tttctgacgg gacgataaaa 3375421 atccaaatga tataaatgag caaaaccggc aagacacttg tcataatggc taagatgaca 3375481 gttatgactc tgaggagtga tgcgtcccaa ttgaaatatt ccgcgagacc tccgataaca 3375541 ccggcgattt tcttattttt ttctgagcga taaagcttat tcattcgatc acctctgtga 3375601 gtactttagt ttgatggcgc ctgttagtga ttctgagaag acggtgatgt tttgatcatg 3375661 tgcctgattt gaagtgaaca tcatttcttt ttgaatcgta tcattttttt ccttcagcat 3375721 ctctacatcc attaattcat gggacagcgt accaagattg cttttcagct ctgccttcac 3375781 tgcgagatcg tccggaattg caagctctac atttccagtc gttgtttttg cataaatgga 3375841 gcggcagtct gattctgtta cgttaatcgc aatatttccg ttaaagcttt gaacgtcaat 3375901 ggattcgctt ttccctcgga gatcgatcaa tccgttaatg gtttccgctt ctatcgtacc 3375961 gcagctgtgg cttgcgagct taatttgccc gttggccgtt tcagctatgg ctttttcggc 3376021 tgttaaatac gagaacgaca gcacgccgtt tgtcgttttc gctgagaact cttttacatg 3376081 taaatgttcc cctctgactg gaccgttaaa cagcttcacc cgaatcttat catactcctt 3376141 ctgaggaata tacaaagtga cattcgtttt catcgtcttt ttctcagtac ggataaaaaa 3376201 cttattacct ttgatttcac attcaatatg ctgaagaaat gcgtgtctcg ccgcatcctg 3376261 gctgtcagcg cgatatacct tcgcctggca ttccgctctg atatcgtcat cttcccaagg 3376321 gacgatattt acgctgccat tggcaatttg cagctcaaca ctggaaaagt cagtatcttt 3376381 aaattgaaaa atgtgctgaa catcatacgc atggccaaag tttaaatcaa ggtcaacttc 3376441 cttgaccttt ttcacagcag aatcaatcca gtcaaacagc ttggctccta aagacggttt 3376501 gccgctttct ttttttgccg ttgtaaatgg ctcttcctcg tcatgaacgt gaactgagag 3376561 cgctgtgatt ttctcttctt tttccttgta gtcgctgtca agcttttcaa tcagtgtcaa 3376621 agcttcttgt gctgtaagct ttccttcctc aacaagctta aggattcgtt ccttttcttg 3376681 cttcattacg atctcctccc cattgtctac ttatgctgca cgcaggacct taatgccctg 3376741 aatcacattc caaatgataa tgccaatgac aactaagaaa taaataaccg ctcccccgat 3376801 gattacaaat acaggaagca agctgtctcc atcaatcgca acggctccgc caagtaaagc 3376861 aataaaaagg aacagccagc cgacaaacgg aacaatgtga gaaataagag agcgtatcgc 3376921 atggcgtttt gtttctttct catttacaac aaaatatgcg acaatcggca caatgattgg 3376981 cgcaatgaac acactgaaat aacaaagtga tgcaataata gcttgattac ggttcaattc 3377041 attccacact cctattgtga attgtccatg acaaaagatc agggacgttt tacttattta 3377101 tacgtttaaa atctcttcag gtttcaaatt cattctttag acatgctccg atttacggaa 3377161 attggatttt aaaaagtttt agaagtagaa tcttccggct ataccgatta caatatgtaa 3377221 aaagcttacg gcaaccaagg aggctggaca agcaatggag aaagatccca gtgactatac 3377281 agtaacacaa gaatcagtgt taaagctgat tcaggaacaa aaaagaatga atcgtgaaat 3377341 gatcaccgag cttgagcaga ttcacggacc cttcccgatc tctcacgata tccaatatat 3377401 aaaagtgctg ctcgacagca gcaacacaca tattgttcaa gatttaatga gtgtaagtaa 3377461 gcagctgtat aagaagactt tgtaattgcg gaaaacatat cattcattat aactgaaaca 3377521 aagctaaagg ttagatgaca atatcttgcc ttttttgttt tgaaaaaaca agtgattccc 3377581 tggctgtcac aaaatgattg taacaaaaaa agcctgccgg cacatccagt taatggactc 3377641 tgtcggcaag ctgtaactat cagaaagaga tagccgttca aaattaacgt aacaattgaa 3377701 gcacgttttg cggctgttgg tttgcttgag caagcatcgc ttgagaagct tgagaaggaa 3377761 tgttgttctt tgtgaactcg ctcatttctt tcgccatgtc aacgtcacgg atacgggact 3377821 cagcagctgt caggttttca gaagaagcac caaggttgtt gattgtgtgc tctagacggt 3377881 tttgtaccgc accaagttta gcacgttggt ttgagacatt gttgattgca gtatcaatac 3377941 tttcaagttg tgtatcaaaa ggagtattag caaaatctgt tacattaagt gcgtttactc 3378001 ctaaagcagt tgatgacatg ctgtcaatgt taactgtaag ctgctggcca gcatttgctc 3378061 caatttggaa agtgaaacca tcagtttcag taccatctaa taactttttg ccgttgaatt 3378121 cagtacgatt tgaaatgcca tcaacttcct caataagcgc atccatttca tctttaattg 3378181 caccaagatc ttctgcttgt tgtgtacctg tgtttcctgc ttgaacagta agttcacttc 3378241 taaacctatt atgccgtaaa gaaaaagctt gcctgctaag cccaaggatg gacttgccga 3378301 caagctgtcc cctcttaaca gagggtttta agatgtagct gtttcttttg ctttcaagag 3378361 cgatttcatg cgtgttttgt cacgttcgat aacaggcttt aaataacggc ctgtatacga 3378421 ttcttcaact tcagtgattt cctcaggcgt tccagacgcg acaatggttc cgcctccggc 3378481 tccgccttcc gggcccaaat ccacaatgta atcggccgtc ttaatgatat caagattgtg 3378541 ctcaataacc agtacagtgt ctccgttgtc taccaaccgt tgcagcacga caagaagcct 3378601 ggcgatatcg tcgacatgca aacctgtcgt cggctcatct aaaatgtaga gcgtacgtcc 3378661 ggttgagcgt ttgtgcagct ctgacgcgag cttcacgcgc tgcgcttctc cgcctgacaa 3378721 ggtcgtcgcc ggctggccga gcgtaatata acctaaacca acatcataaa gggtttggag 3378781 cttgcgtttg attttcggga tattttcaaa gaaagaaaga gcatcttcaa ccgtcatatc 3378841 aagcacatca gagatgcttt ttcctttgta cgtcacttca agcgtttcac ggttatagcg 3378901 tttgccgtga cacacctcgc atggaacgta tacgtcagga aggaagtgca tttcaatttt 3378961 aataatcccg tctccgcggc aggcttcaca tcgtccgccc ttcacgttga agctgaaacg 3379021 gcctttttta tagccgcgga ccttcgcttc atttgtctgc gcgaatacat cacgaatgtc 3379081 atcaaataca ccggtgtatg tcgcagggtt ggatctcggc gttcttccga ttggcgcctg 3379141 gtcaatgtca atgactttat ctaaatgatc caaaccttta atctctttat ggctgccggg 3379201 cttcgctttc gctttatgaa gcttttgcgc cagcgcctta tgcaaaattt cattaacgag 3379261 tgtactcttt cctgaaccgg aaacacctgt aactgctgta aacgtcccaa gcgggaactt 3379321 ggcattcact tttttcaggt tgttttctga tgcaccttta atttcaatgt aacgtccgtc 3379381 cggctttctt ctttcaggag gcaatgggat aaactttttc cctgataaat agctgcccgt 3379441 taatgaattt ggatcttcca tcacttcttc cggcgtaccc gcagatatca cctgtccgcc 3379501 gtgaatgccg gctcccggtc caatatctat taaataatct gctgccatca tcgtgtcctc 3379561 atcatgttcg acaacaatca gcgtgttccc gaggtctctc atatttttca gagcgctgat 3379621 caagcggtcg ttatcacgct gatgcagacc gatagacggc tcatctaaaa tataaagcac 3379681 accggataaa cgcgagccaa tttgagtcgc cagcctgatg cgctgcgcct ctcctccgga 3379741 caatgtaccc gctgccctgc tcaatgtcag gtaatcgagg ccgactttgt ccagaaagct 3379801 taagcgctcc acaatttcgc gcaaaatcaa attggcgatc tgcatatcct tctcagaaag 3379861 ggtaagatct ttaaagaagg caagtgcgtc ggcgacagac agctcggtaa ttttcccaat 3379921 gtggcggccg tcaatcagta cggcaagcgc ctctttcttt aaccgatagc ctttgcacgt 3379981 cggacaagac ttctgagaca tatactgctc catttgctca cgtatgaaat cggagcctgt 3380041 ctccttatag cgtctttcaa tgttgcgcaa tacgccttca aattgaattt caccttcgcg 3380101 gatttgtcca aaatcatttt catatcggaa ataaatcagg tcatccccgc tgccgtacag 3380161 cactttatcc agttgatgct tcggcaaatc tttgaccggc acatccatat caatcccgta 3380221 gtgggtgcag actgcctcaa gcagctgagg ataatattgt gagctgatcg gtgtccaagg 3380281 ggcgaccgca ttctccttca atgacaaatc ttgattgggg atgacaagat cggcatccac 3380341 ttcaagcttc attccgagac cgtcacacgt cggacacgcc ccgaacggac tgttaaacga 3380401 aaacagacgc ggctcaagct caccaattga aaatccgcag tgcggacagg catgatgctc 3380461 gctgaacatc agctcttcct caccgatgac atcgatcata acccgtcctt cacctaaacg 3380521 aagcgccgtt tccaatgaat ctgacagccg ggctgccacg ccttctttca cgacaatccg 3380581 gtcaatgact acctcaatgg aatgcttctt gttcttttct aattcgatat cgtcggaaag 3380641 ctcagccatc tcgccgtcaa ttctgactct gacatagcct tgtttcctaa tctgttcaag 3380701 cactttgaca tgagcgcctt ttcggcccga gacaatcggc gccagcacct gaagcttcgt 3380761 ccgttccggg tattccagaa ttctgtccac catttgctcg atggtctggg atgtaatctc 3380821 aattccgtgt tccggacaat gaggcttccc tactctcgca tataaaagac gcagataatc 3380881 ataaatctca gttaccgtac cgacagtaga cctcggattg cggctcgttg ttttctgatc 3380941 aatgctgatg gcgggagaga gcccctcaat tgcatccaca tccggcttat ccatttgccc 3381001 taaaaactgg cgggcatagg cagacagcga ctcgacatac cgtctctgtc cttcagcata 3381061 tatcgtgtca aaggcaaggg aggatttacc tgatccggac aaacccgtga caacgacaag 3381121 ctgatctctc ggaatcgtta catctatatt tttcaggtta tgcgccctgg ctcccttcac 3381181 ctctatccga tccatagcca tttgttcatc atccttccgc ttttagctct aaaagtaaat 3381241 cgcgaagctc cgcggctctc tcaaagtcaa gcgccttggc ggcttccttc atttcatgct 3381301 ccatctgttc aacgactttc tggcgttctt tcttcgtcat tttcgacagc ttcggcgcgg 3381361 cttttgtttt gtattccgct ttatcctcag ctgctactgt ggcacgaatg acatcgcgaa 3381421 tttctttatt tatcgttttc ggcgtaatgc cgtgctcttc gttaaaccgc tcctgctgct 3381481 cgcggcggcg ttttgtttca ttaatcgcaa tttccataga cttcgttatt ttatcggcgt 3381541 acataatgac gcggccttcc gcatttctcg ctgcccgtcc gatggtctgg atcagcgacc 3381601 gctccgaacg aaggaaacct tccttatccg catccaaaat cgcaacaagg gatacttcgg 3381661 gaatgtccaa accttccctc agcaggttga tgccgacaag cacatcgtac ttgccaaggc 3381721 gcaggtcgcg gataatttca atccgttcaa gcgtcttgat ctcagaatgc agatagttta 3381781 ctttaatgcc gatttccttt aaataatcgg tcagatcctc tgacatcttc ttcgtcaaag 3381841 ttgtcacaag cacccgttca ttccgctcga ttcttgcttg aatttcgccg atcaagtcgt 3381901 caatctgacc ttcgattgga cggacgtcaa taagcgggtc aagaagcccc gtcggacgaa 3381961 tgatctgttc gaccatttca tctgtatgtt caatctcgta cggccctggt gttgctgata 3382021 catacacgat attgtgcata tgcttttcaa attcctcaaa acgaagcgga cggttatcaa 3382081 gcgctgatgg aagccggaag ccgtgatcca cgagcacctg tttccgcgcc tggtctccgt 3382141 taaacatgcc gcgcacctga ggaattgtca catgcgactc atccaccacg atcataaaat 3382201 cgtctgggaa ataatcaaga agcgtatacg gcgttgaacc tggaggccgc agagtcaaat 3382261 gtcttgaata gttctcgatg ccggagcaga aacccatttc acgcatcatt tcaagatcat 3382321 atcttgtccg ctgctctaaa cgctgcgctt caaggagctt tccgttttca tgcatgacct 3382381 tcagctgctc ctcaagctcc ttctcgatat tttgaatcgc cttctccatt ttctcggccc 3382441 gcgttacgaa gtgggatgcc gggaaaatcg caacatgatc tcggtcgccg agaatttctc 3382501 ctgtcagcgc atctacttcc cgaatccgtt cgatttcgtc accgaaaaat tcaactctga 3382561 cacaatgctc atcacgggat gccggaaaga tttccactac atccccgcgc acacgaaatg 3382621 taccgcgctg aaagtcgata tcgttgcggg catattggat gtctacaagt tttctgagca 3382681 gctcgttgcg ctcaatttcc atttcagtcc gcagtgacac gaccatttcc cggtattcct 3382741 caggcgaacc gaggccgtat atacaagaca cactcgcaat aataatgaca tctctgcgct 3382801 caaacaaagc tgatgtggcg gagtgtctca gtttatcaat ttcatcatta atactagcgt 3382861 ctttctctat aaatgtatcc gtttgaggca catacgcctc cggctgataa taatcatagt 3382921 agctgacaaa atactcgaca gcattgttcg gaaaaaattc cttgaactca ctgtaaagct 3382981 gtccagcaag ggttttgtta tgggcaatca cgagagtcgg cttattgact tctttaatca 3383041 aattggacac cgtaaatgtt ttcccagttc ctgttgcacc cagcagagtc tgatgcttct 3383101 tgccctcctg aattcctttc acaagctttt caatggcttt cggctgatct ccctggggct 3383161 gatatttcga gactaactca aagcgatctt tcacaaaaat aagcctccgt ttctttaacg 3383221 aaatcttcct atagatatag taacacaatg gaaagcaaaa tcactaaaaa tacgaactaa 3383281 agttcggtgg ttttttattt ccagctgttt ttgtgtataa aaaacctgct tttaaaacgt 3383341 aaaagcaggt attcagtctt tatattcatt atgtccgatt tattcttctt ttttctctgc 3383401 agcttttttg gccatataca gtccgccagc cacaagagac acaacatcca atcctacaat 3383461 aaaatacgtt tctgtatagc cttttaaata agaggcaaac agcaatgcag ctgttaaagc 3383521 gatcgccaca taatgattaa aggtgactct agtaaataga acaacaagca taaaagggaa 3383581 aaacaatgca aaaacggctt ttgtaatcaa caaaaaccct cctcagggat tcttcatctg 3383641 atctgattat agtaaaaaat gaagaatcgg acaatcgtgc attcgctccc tctacttaca 3383701 ccatacccct tttcagccaa aatcaatcac catatttgca ttttggtgcc ggtcaaaact 3383761 tattccatgg tgccgctgtt ctaatcagcg gcactttttt tattacatca tcaagtccgc 3383821 cgccagattc cgagaataaa agaaaatagg catacagtac cagtacggcc gcatttttca 3383881 ggataatata accaacttaa ctattcattt tatttaggac tttctgcgtt tgacagcatt 3383941 ttcctgaaaa cctacaatta aatgatagtg tttactatca ttttttaaac acaggctccg 3384001 caataaaaag actagagaga aaaacaaaat gaatgaagaa aagaggggtt tcaaatatgt 3384061 attctgtttt atttcgccag gcagaagagt ccagccagct ggctggagca aaaggaatga 3384121 atttgattaa attgaccaaa cacggtcttc ctgttccgga cgggtttatt attcaaacga 3384181 atgcgctcgc acgttttatg gaggacaacc agcttcaaga gactagtgaa aacgtcgaag 3384241 gcgggatcat ttccggaaca ttttcggatg agctgaaaga tgagctgact agttcctttt 3384301 ataagcttag agaatcatat cgatccgtag ccgtgcgttc ttcgtctgct tcggaagatt 3384361 tagaaggcgc ctcattcgcg ggtcaatatg aaacctactt aaatatcaaa acagaggaag 3384421 agtttctggc taaagtgaaa gaatgctggg cctcattttt ttctgggcgg gtcagcagct 3384481 ataagaaaaa aatgaacaat caaatcgcag agccgttaat gggaatagtc gttcaggggc 3384541 tgatcgattc agaaatgtca ggtgttatct tcagccgcaa ccctgttacc catgatgata 3384601 gagagctttt aatcagcgcc agctacgggt tgggtgaagc tgttgtttca ggaaatgtta 3384661 ccccagacac gttcattgtt aataaatctt cgtttgagat tcagaaagaa ataggtgcaa 3384721 aggaaatcta catggagtct gcggcagaag gaattgctga aaaagaaacg agtgaagaca 3384781 tgcgcagccg tttttgcctt acagatgaac aagtgattga attggctgaa atcacaaaaa 3384841 aaaccgaaga cctgtacgga tatcctgttg atatagaatt tggaattgct gatcatcaaa 3384901 tataccttct gcaagctcgc ccgattacaa ccattgatca ggacaaaaaa gcggcagaag 3384961 aaaaacgcag cttcatgatt accgacactg atatgaatga tttctggctt aacatggagt 3385021 ctaatattga aggtccggtg agtccgttat tttcatcctt catcgtgccg gcattggaat 3385081 atggcttgaa gaagagcatg caaaagtttc cgattggtgt agttgttgat gaagtaaaac 3385141 tttatcgcgg acatatttat tccaaaaacc aaggcggaca gcagcctcct tctgaagact 3385201 gcggcaaaga gcttttcccg attttatcgg agcatatgta tgacatcatc aatcacacat 3385261 acctcccttt ttaccggaca ctggaccagc tcgcacaaac tgagcatacc gcagaaagcg 3385321 cactggaagc ttttcaaaaa ctaaaggcct tttatctcac ggcttatgaa gagcacttta 3385381 atatcgtttt cccgcaaatc cttttaacaa acaaactgca agcgatgtat caggacattc 3385441 aaggagagtc cgaaaacgct catttttacg agatgctgac aggaaaaatg aacaaatcac 3385501 tggaaacgga ccgttgctta tggctatttt ctgtggaagt tcaggagaac ccgaaccttc 3385561 tggccatttt tgaaaacaac aagcctgaac agctccagga gaaattggaa caaacagatg 3385621 agggaagaca cttcctgaag aacgtccatg aattcttgca agaatacgga tggagatctg 3385681 ttaaaagtca tgatctgatt gaacaaatct gggtggaaaa tccgtatttc gctctggcca 3385741 atattcaaaa ttatgtccgt aatggctatc attttgacaa tgaatttcag aaaacaaaag 3385801 aaaaacgaga gaaattatac aatgaattct tggaaagcat agaagatccc ggtttacgca 3385861 ccgaatttga ccgctattat caatggacac tgaactctgc aaatataaaa gatgatcacc 3385921 acttttatat tgacgccatg ctggatgcca aggcgagaat ctttctgctg aagataggtg 3385981 aattgctggc ggaaaacggt gtcattcaag atcgggagga cctttggttc ttatatgacg 3386041 acgaagtgga acaagcgctt cttcaccctg tatccctgca agaaaaggct gaaaaacgca 3386101 gacagatttt tcatgagtat gagctggccc aagccccggc ctacctcggc accccgacaa 3386161 aagaacagct caaagcagct gaagaaattg tcggcgctgt gatagaggat gaaaaaaaca 3386221 cagagaatca tatttttggc attgcggcat caagcggcat tgcgacaggt ccggtgaaaa 3386281 tcattcggga cgccaatgaa ttttctcaat tcgcgcctgg agacgtactc gtttgcaaga 3386341 tgaccacacc gctatggacc agcctgtttc aagacgccaa agcgattatt acagacacag 3386401 gcggcatttt gtctcacgct gcgattattg cccgtgaata cggcattcca gccgttctcg 3386461 gcacacgcac ggcaaccgaa agactgcgag acggtgacat catcactgtt gacggaagca 3386521 gcggcaaaat cacagttgtc agccggtcct gatgcgtccc cctctttctt atacaagcgg 3386581 ggcgggtgta tacttgtcct gccagtatat tcgtgaggtg aaacgtattg agaccgacaa 3386641 acaagagaat ccttgatgct gccatgcagc tgctcgtcaa aaaaggatat cgcgcaacga 3386701 ctacaaaaga aattgcagaa aaagcaaatg taagtgaagc gacgattttc aggaacttta 3386761 aaaacaaaca aggactagtt gaggctttgc tttctcagca ttcttcaaac agaggcagca 3386821 ttttggaaca aacagaaggg gatttgtaca aagacctgct tcatatcgga acctgtctct 3386881 tggaggagct cgaacataga aaagatatca ttaaaatcag ctttcgtgaa ccggccatgt 3386941 ttcaggatgt cattaaccac gtcactgaat atccccaatc tatgaaacag ctattggttg 3387001 attatctcaa aacgatgggt gagaaagggg ttattcagac aggaaatgaa gcggaacatg 3387061 ccgacgtgtt catgtcgatt atcttcggtt atttcattca ccgtctccac ttaggagacc 3387121 gggtcatatc aatgccccag gaaaaaatgc tggagcatag cacagctcta tttgtcaaag 3387181 gaatttctgc tgattaactc cttggcataa taaaaaggag gatcccaatg agctcaagaa 3387241 aagaatgggc gctgatcgtc tcgctattat tgggggccat tctggttccc attaactcaa 3387301 cgatgatcgc ggtcgcgctc tcatctattt cccatacgta taacgagtcc atcgcaagca 3387361 tcacttgggt ggttaccgtt tatttaatcg tgatggcagt cacacagccg attgcaggaa 3387421 agctcggtga catgtacggc aataaaacaa tgtacttatg gggagtcggc ctttttctaa 3387481 tcgcatctct aggctgcgcc ctttcaccga gtctgctcct gttaattgtc tttcgggcat 3387541 tgcaggctgt cggcggggca ttgcttacgc caaacagcat tgccattatc cggcatgttg 3387601 tttctgaaaa acgcctaccg aaagtgtttg gatttttcgg actgggcgcg ggacttggtg 3387661 cagcactcgg gccttttatc ggctctatac tgattgacag cttcagctgg cattcgattt 3387721 tttgggtcaa catcccgttc ctcgccattg ctttatttac ggcattaacg atgtttcctc 3387781 aatataaaga aaataaatct gacgcgccgc tggatatcat cggctctctc ttgcttgcag 3387841 gcagcatcgt ttccattatc ctgctgacga aaaatgaggc tccatgggga tatactgtat 3387901 acagtgtatt gatacttctt tttgttccgc tttttttcag aagagaaaaa cgtacccagc 3387961 accccatcat tgactttgca ctgtttaaaa gctcaacctt tacaaatgcg aatctatcag 3388021 tcttgttaag caatttgatg atgtatgccg tcttattgat tatgccgtta tttatgacga 3388081 accaatttgg gcttaataca tctaacagcg ggatggcgct ttctgtattt tcgatcttca 3388141 tgtcagccag caactgggtg ggcgcgcagc tccatcacaa atggggagcc aaaaaaatca 3388201 tttttctttc atttgccatg atggctggtg cgaatctatt atttttgctg ttaagcagct 3388261 cgcattctgt cttgttcctc atgctctctc ttatccttgg cgggctcgct tccggagtcg 3388321 gtctgaccag catgcaggtt tcatcccttg ccacagtaga ccccggtatg tcaggagtgg 3388381 catctgggat tttctcgacc ttccgttatt tcggaagcat catttcatca gccttaattg 3388441 gcctgatttc gggatatcac accctattta tgattctctt tgctgtatcc atcatcggcg 3388501 tttttgtttc attgggcatc aaatctgatg aaacggcacg gatagaaaaa aactcagcgt 3388561 aacacaaaac agcccggcat cgcatcatcc tgcggtgccg ggctgccttt tatgatcccg 3388621 aagcgactgc ttcgtcttca cggtcatcct ttacgaagag gatgcccaat tcatgatgtt 3388681 ctccttcata agaagctcgc tggtcaaaac gaatttctcc attcaaaccg ataatttcaa 3388741 gctttacata tgcacggtta tgctgaagcg cttcatagaa atcagaaacg ttcttaaccg 3388801 gtatgccatt gactttcgtt atgatttccc cgattttcaa ttccagatcc tcagccggcg 3388861 tattggggat aatcccaagc accattaagc cctgatccct tttcgagaaa taaaacggag 3388921 ccgcgttatc attcactctt tgctttatgg acagaaaaat acgccctaac aaagcggtac 3388981 agaccgctgc acccgcaagc ggcgtccaca gtaagctcgc tgcaccgaga actgcgacgg 3389041 caagaccgag aatacaaacg cgtttcgctg tgatccttat actcgtttca ggcagcgatc 3389101 cctgtaccct ttgtccaaat ccgacaaagt aaggaatcca tagaaaatgg aatgagccgc 3389161 cgggaaccgt aaacacgggc caccagctaa ggtgcgattc taaaccatta ccgggcacga 3389221 gaaggaacag cggcaaaagc caaacccggt ttgccagctg ctgtccgatc ggcaaaccgc 3389281 ggctgcttac gacaagtgcc ggtgatgttc tcacatgcgc agaacgataa gcaaccgctc 3389341 cttcagtgat aatcagcaaa cctagaaaca cagccacagc cggccaaaca actgcaaatc 3389401 cttgcggaaa tctctccaga aagggctccg cctgatatat ttgcagtcca aaacctatca 3389461 gcatactcac actgacgata tatgcagcag acatccagtt tgcgcgaaga gtgaacgctg 3389521 ccgctgcagt gataacggca ataatcgcaa gtaaaccgag aggaatcgat attccgagtc 3389581 cacctaaaat aactgacaaa agaagacctg gaatcagtcc ctttgtatat gtaaatttca 3389641 gatcatcata aatatctgct attcttgtat gaaaggtttt tcgttcccgt ttgattctta 3389701 catagccgaa agccaaggtt atgatgataa aaaaccagaa aagcgggtgt aagaagaaca 3389761 agcccgcgct ttttaacagt tcaattcccc attgaacaga cactatctct caccgcctca 3389821 agccaaacat gttactcata ttctatcaaa tattaaatgg cttggatatc ctcaggagag 3389881 tttatctctc ttgcgtcatc cacagcgtga cattcgatag tgaaaaatcc tttaaatagt 3389941 ggtttacatc cacatccaat aacccgctga ttagatgcat cgaccttttt atatctgtca 3390001 gattaattcc taatcgctta tggtttttca ttaagtagtt aaaataatgt ttggcgcatt 3390061 cctcattaat gtcatttact gattcgacat tggtgtaatt gaccaaatat ctgctgaaca 3390121 gcataagaag acttagtgct tttgtagctg aaaatgttac gtcttgtgtt ctgtctttta 3390181 attgttccac taattcataa tatttttttt tcacgcacaa tacttgccct cttcaattgt 3390241 gaacccccat tttctttata cagataagca cgggccagta taagcagcag tactggagtg 3390301 ctaacaagca ttctcgctaa cgttactctt taaatacctg tcgttcagct gccattaacc 3390361 tgattactgt tctttttaga accttcttat attgtatgaa gtaaacaaag actaggcaac 3390421 ttgcaaaagt ttcattttaa atgcatatta actcgttaga aagtctctct catatattga 3390481 tatcgggtaa taacagtcct ttataaatgt ttatttgtga aaattttttt aatttcttgt 3390541 caaaaactca ttttttatgt gacttatgat ccataatctc tttaagcaca aagaaacagg 3390601 agatgaaata ccatctcctt taattgacaa ataatgattt caatgctgtt tgaagctgca 3390661 aatcattttt ttcatctgat tttttctttt ctatctgctg atttaatgtc tctgcagtgc 3390721 gagtgtcgat cacaccggtt ttattcagct tgttttgatc ctgaaaagcc ataaccgctt 3390781 ttttcatgtc tttgctgaaa tagccatcct cacgtcccgg atcaaagctg agacctttta 3390841 acaatacctg cgcatgcttg acgtcttcat tgttcatgtc cactttaagc ggctctttca 3390901 gctgtaaggg cccggcggaa aaataatcgg gctgcttaat cgcaatggtc ggttcaattc 3390961 ctttcttatg aatccagttt ccatttggcg tcagccactt gtaaagcgtt aatttgatgt 3391021 tgctgccgtc ccccattggc acagcctgtt gaaccgttcc ctttccaaaa gacgtatcgc 3391081 ctacaacatc ataatggcca gcttccttta atgcgccggc aagaatttct gatgcagagg 3391141 cacttccttt atccgtaatc acattgacag ggtacgcttt tttatgggtc aatgttgaaa 3391201 aataacgttt tttatctcca ttgcgttcag caatctgaat atacggctga tcctttgtaa 3391261 cgaaatgctt aagaatttct tccacacttt gaagatatcc acccgggttg ccgcgtacat 3391321 caatgacaag tccttctatt tcttttttct caagctccct cagcgctttt gcaaaatcct 3391381 ctgcggtgtg ctcagaaaaa gtagagatgg caatatatcc gacagaatgc ccctgtactt 3391441 ttttctctga tgcaaaaacc gtttcgagcg gaatctcagc tctcttgatc cggaatgaca 3391501 actgcttctt cgttccaggc cgctgaatct tcattgaaac gctggaccct ttttttcctc 3391561 ttatttttaa cacagcgtgg tttaaatcct tgccggccat cgattctcca ttgatgctga 3391621 taatttcatc attaggcttc aacccggctt tttccgctgg cgatttcttg aatggagaaa 3391681 caataataat tttgccgtct tccattccaa cctcagcccc gatgccttca aatgaggaat 3391741 caagagaatc agaaaattgc ttagctgtct gcttgtccat gtaaacagaa taaggatcat 3391801 ttagcgtaga cagcattccc tggatggctc cctcgagcag cttttctcta tctacttttt 3391861 ctacgtactc attcgaaatt aactcatacg ctttttcgat tttgtccata gctttatccc 3391921 gttcagagtc agcttgtgcc gtcgcgggaa ctgctgcagt ctggggctta tccatctcaa 3391981 gcaggttgat tcccgcatat acaccggcgc ctccgaacag catgctccct gctgctatca 3392041 cagccattat tttttgattc atcctttact cctcctgtat gccagactgt ctttaccaaa 3392101 acctagagat agtatatgta aaggatggag atttcatgta atcatagaag aaaaagaagg 3392161 caaatgaaaa gccgtcccga aaacggaacg gctttttcac tttatactcg cagaaacttg 3392221 cggatggaag tcagacttcc ccatactcca attactgcgc cgattgcaat cagcactagc 3392281 gaaacttgga atacaaatgg attataagga agaagagaga caaatgatcc ttgaaccttt 3392341 ggaacgaccc atccgatgac gtattggtaa gtgctcagca ccagtgcaat cggaatcaca 3392401 gaaccgaata cgcctagcag caatccttca aggaaaaacg gccagcggat aaaccagttt 3392461 gtcgcgccga caagcttcat gatttcaatt tcttttcttc ttgcgaaaat tgtaatttta 3392521 atggtgttgg aaattaagaa catcgccgta aataccaggc cgataattaa cgcgattccg 3392581 atgttgcggg aaacgccgac cactttaaac aaacggctga cctcttcttt tccataagtg 3392641 actttataaa catgatccat tttttcgatc tttttcgcca cgttcggcgt atcatgcgga 3392701 tctgtcgttt tgacgacaaa cgcatcatta agcgggtttt cctgatcctt cattgtcagg 3392761 gattttccgc tgtcaccaaa actgtcaacc agctggtcaa gctctttttc tttagatgaa 3392821 aaagtgacac tctgaatgcc cttcagttcc ttaatatcgt tctgaagctt gtcctgtgcc 3392881 ttctgatctg cagtcagatc aatcagcact ttgatttcga cttgtttttc tgcattcgtg 3392941 gccatgttat tcaaattcag cataatcact aaaaacacgc cgactaaaat cagcgtaacg 3393001 gttacagcac taatggatgc aaatgtcatc catgtgtttc tcccgagaga tttaaaactc 3393061 tcacgcaagt ggcgcccgag aattttaatc atatgaacca tactcccctc ttgactcatc 3393121 acgcacaatg ataccatctt cgattgcaat gacacgtttc ttcatggtgt ttacgatttc 3393181 tttattatgt gtcgccatca cgactgttgt cccgcggttg ttaatttcct ccagcgtctt 3393241 catgacttcc caggacgtat ccggatcaag gtttcctgtc ggttcatcag caatgacaac 3393301 atcagggttg ttcacaattg atctggcaat agatacacgc tgctgctccc cgcctgaaag 3393361 ctggtcagga aattgtcgcg ctttatgctt cagctgcacg agatcaagca cttcaagcac 3393421 ccgtttctta atgacagacg gctgttctcc aatcacttca agggcaaatg ccacattttc 3393481 aaaaacagta agtttcggaa gaagcttgaa atcctgaaag acaacaccta ttttgcggcg 3393541 cacgaaagga atctcttttt ctttaattgt cgcgagatct ttatgattga ttaaaatttg 3393601 tccttttgtc ggtttttctt ctctgtaaat cattttaata aaagtagatt tacctgctcc 3393661 gctcggacca acaacataca caaactcgcc gggatgaatg gtaacagaaa tcccattgag 3393721 tgcttttacg ccgttcggat aggctttata tacttccttc atctctatca tgaaatcacc 3393781 taatctttta tatcatttta tctatcacac ggtcatactc ttcgaatgca ttcgacaatt 3393841 tatgacccat tcatttgtaa aaagatgaaa aatctgaaag ttcccttttt caatacactt 3393901 cattatacgt caaatttaga cataatacta ttacagtttc ttttcattca tattgtcaag 3393961 gcataaaaac atccttgcca gcactcggca aggatgtttt tatcttactt tttttctgac 3394021 agccatttgg caataacagc ggcttcgtta tcatctacaa gcccctttgg catattgccg 3394081 cggccgtttt taataatgct ttcaattttg tgttcatcgt atttgcctcc gacctcttgg 3394141 agattaggcc ctgacacacc ttctaaatcc ttgccgtggc agcctacgca gctttgctga 3394201 tataattctt ccccttcaga tgcagtggct tccgtcttgc tgccagtgtc tgtcttctct 3394261 tcttttgcat cgtttgatcc gcaggcagcc aacagaacag aaagcgcaaa tccaatcatt 3394321 agtatcgata actttgattt catgttgaga agcacaactc ctttacgatc tcttccatat 3394381 tataacctcg tttaagcgcg tttgaaaccc tcgcccagca cctcgctcgc gtctgctaca 3394441 attacaaaag ctgactcatc aatctgtttg acgatttgtt tcaatttggt gaattcagtt 3394501 tgcccaacca cgcacattaa aatcggacgg tcatcgtcag tatatccgcc gactgcagaa 3394561 atttttgtca cgcctctgtc aatcttctgt aagacagcct ccttgacagc ctgctcctgc 3394621 tttgtaatga tgagcgccat ttttgaacga ttaaagccga cttgcacaac atcaatggtt 3394681 ttgctggaca catagacgcc aagcatggca tataagcctt gctcaatatt aaatacaatc 3394741 atagccgtaa caacgatcat tccgtcaatg atggcgagac acttccccaa tgacagaccg 3394801 gagtacttat gaatgatctg tgcagccaag gctgtacctc ccgtcgaacc tttccctaag 3394861 tacacaatac caattccgat acctatcccg acaccgccaa aaatcgccgc caggagttca 3394921 tgatgagtgg cgggctgaat atcccttgtc agaaacacta ctagcggcaa aaacacagaa 3394981 cctgcaagcg tctttagtcc aaatttcccg ccgagcaaaa tgacgccagc aataaataaa 3395041 gggatattaa taatccactg tacatacgct gcttcaaaac catatgattg taaaatcgta 3395101 ctgatcccgc tgaccccgcc ggcggcaatc ttattcggaa gcaaaaatac attaaaggac 3395161 acggccgtaa tcgctgctcc tatcaatatg tatacataat cccgcaaaat ccacaatgtt 3395221 ttattccgta cgtccatcat atatcctccg tttcttccaa tgctctccga tagcatttta 3395281 atccttccct gattagatgt aaataacacc caaatacagt ggtaatatgc taaagcagca 3395341 gtgaaatcaa ggatataaga aataaaaaaa cacacccgta tgcatcaggt gtgtttttca 3395401 gcttatgaaa gcttagaacg caggtaggca tcaataaacg tatcaatgtc accatccatt 3395461 acagcttgaa cgttccccat ttctgtattg gtccgatggt cttttaccat ggaatacgga 3395521 tggaatacat aagaacggat ttggctgccc cagccgattt ctttttgttc accgcgaatt 3395581 tcatccagct ctgcctgctg ctcttcaatt ctgcgctgat acagcttggc cttcagcatt 3395641 ttcatggctc tttcacggtt tttaatttgt gagcgctccg tttggcatgt cacaactacg 3395701 ttcgtcggca agtgagtaat ccgaacggct gaatccgtcg tattgacgtg ctgtccgccc 3395761 gcgccgcttg cacggtacgt gtcaacttta atatcctccg tacgaatatc aatatcaatt 3395821 tcatcgttaa attcaggcat gacttcacat gaaacgaaag atgtgtggcg gcggcctgat 3395881 gaatcaaatg gtgagatccg cacaagacga tgaacacctt tttctgcttt gagatacccg 3395941 taagcgttgt gtcctttgat gagcaatgtc actgacttga ttcccgcctc gtcacctgga 3396001 aggtaatcga gagtctctac tttaaagccg cggcgctctc cccatcttgt atacattcta 3396061 agaagcatag agccccagtc ctgtgactct gtaccgccag caccagggtg cagttctaaa 3396121 atcgcgttat ttttatcata cggctcgctg agaagaagct gaagctcaaa ctcattgaac 3396181 tcttttgtta atgactttag ttctttttca agctcaagct ggagatcagt gtccggctct 3396241 tctttcaaaa gatcatgagt catttgtaat tcttcgtggg attcattcaa ttttttatac 3396301 gaattgacat aatcctttaa accgtttgct tcatttataa ccgtttgagc tttttgctga 3396361 tcattccaga attccggatc agccatttgt tcatctagct cagcaatgcg ggcctccttt 3396421 gattcgaggt caaagagacc ccctaaagtc cgctaaacga gaagccatat tttcgagctc 3396481 tgctctaatt tctgataatt ccatttcatt cacctcatta aaagatccgc aggcgcctgc 3396541 aggcgccgcg gtcagtaaac ttgccggggc gaactattca gtacggccgc agcaattttt 3396601 atattttttc ccgcttccgc agtggcatgg ggcatttcgt ccgatatcaa ccactttgcg 3396661 aaccggtgct ttctttgctt ttttgttatc gtcgccttct tgcggctgat gagctgttgt 3396721 ttgaccttgt acaacctctt cacgctccag attgttttca atctcagctt tcatcacaaa 3396781 ttttgcgact tcgtcctcaa ttgattcaat catatgctca aacatcgcaa aaccttccat 3396841 ttgatactca cgaagcgggt tcgtctgcgc gtaagcacga aggtgaatcc cttggcggag 3396901 ctgatccatc gcatcaatat gatccatcca tttagaatca acggcacgaa gaacgataac 3396961 tttttcgaat tcgcgcattt gctctttgcc gaattgctct tccttctcat tatattttgt 3397021 gatgatgcga tccataatga gctcaagcat ttcatccggt tctttgccga agatatcgct 3397081 cttctcaagt gcaccttcat caagataagt tgtgttgata agatcaacta gaccgtcaag 3397141 cttccactcc tcaggaagct cttctcttgg cgtataggct gcaattgcgc gttcgagaga 3397201 agacttgatc atattttcaa cgatttcacg caggttttca gagtcaatga cttcaaagcg 3397261 ctgcttataa atgacctcac gctgctggcg gagaacatca tcatattgca gaagctgttt 3397321 acgcgaatcg aagttattgc cttcgacgcg tttttgagac gattcaaccg cgcgagatac 3397381 cattttgctt tggattggag tagagtcgtc catgccgaag cggtcaagca tcgccattgt 3397441 ccgctcagct ccgaatctgc gcatcaattc atcttccata gaaagataaa attgagtaat 3397501 ccccgggtct ccctgacgtc cggaacgacc tcgaagctga ttgtcaatcc ggcgtgattc 3397561 atgtcgttct gttccgacta cagcgagccc gccaagctct tttacacctt cgccaagctt 3397621 aatgtccgtt ccgcgccccg ccatgttagt cgcaatcgta actgcgcctt tttggccggc 3397681 ctcttcaatg atctgcgctt cacgttcatg gtttttggca tttaacactt gatgcggaat 3397741 tcctttgttt ttaagcagct tagaaatcaa ttcagatgtt tcaacggcaa ccgtaccgac 3397801 tagaacaggc tgtcccgtca tgtaacgctg tgcgacatcc tccgcaactg ccttaaactt 3397861 tccttccatc gtgcggtaaa ttaaatccgg gcggtcatca cggacaacag gcctgttggt 3397921 agggatcgtg acaacctgca tgttgtagat gttgcggaat tcttcttcct ctgtcttagc 3397981 tgtacccgtc ataccggcaa gtttttcgta cattcggaag tagttttgga acgtaatcgt 3398041 cgccaaggtc atgctttcgt tttgaatctc aagcccttcc tttgcttcaa tcgcttggtg 3398101 aagcccctca ctgtagcggc ggcctttcat cagacgtccc gtgaaggaat caacaataac 3398161 aacctgtccg tcttccacta catagtcaac gtccttttgc atcgcaacgt gagcttttaa 3398221 ggcctggttg atatggtggt tgagcgcgac atgcttcaca tcaaagaggt tatcgatgcc 3398281 gaatgctttt tccgccttcg tcattccttc ttcagtaagc tgtacagctt ttgttttgat 3398341 atcgtacgtg taatccttct ccgcttttaa cgtgcggaca aaagcatttg cctgtacgta 3398401 cagcttagtg gattttgcag cttgtccaga aatgataagc ggtgttcttg cttcatcaat 3398461 taaaatagag tcaacttcat ctattaccgc aaaatgaagc gggcgctgaa ccatctgctc 3398521 tttataaaga accatattgt cacgcaaata gtcgaagcca agctcgttgt ttgtggagta 3398581 agtaatatca gcggcataag cttcccgttt ttcgtctttt gacattgagt ttaaattcaa 3398641 accgacagtc aaaccgagaa actcgaaaat tttccccatt tgctcagcgt cacggcttgc 3398701 caagtattcg ttgacagtca cgacgtgtac gcctttaccg gttaacgcat ttaaataaac 3398761 aggcagggta gacgttaatg ttttcccttc ccctgttttc atttccgcta tatttccgtc 3398821 atgaagcgcc acgcccccca tgagctggac tttaaacgga aacatgcctg ttacgcggcg 3398881 tgaagcttct cgaacaacag cgaaagcttc aacaagaaga tcatccgttg tcgccccttt 3398941 ttcaagacgc tctttaaatt caattgtttt atgtttcaat gcgtcgtcag agagattttc 3399001 atagtctccg cgaatcgcat caatatcgtt agcaattttt tcgtatctat tcagcgtacg 3399061 ttttgttgga tcaaacattt tatttaaaat tccaagcatt tataacgctc ctctatcatc 3399121 acacgcctat tttagaggca tgtataaata atttactagt ccatgtatac ctctcattat 3399181 catatcatac cttttgttat ttccaaagaa tttgcaaata agaaaaacaa aaaccttccg 3399241 cggacatcac ggaaggcttc tcttcattat tcagtcggtt caattaagcc atatttcccg 3399301 tcatttctgc ggtacacgac atttgtaagg tttgtttccg catttgtgaa aacaaagaaa 3399361 ttatggccga gcatattcat ttgcaagatc gcttcttcac tatccatcgg ctttaaatta 3399421 aagcgtttct gacggacgat gtccaagctc tcctcctctt ctatgtcatc ctgaaccgca 3399481 atatctgtat cagagccaag accgtttgcc aataaatatt ttggagagcc ctgctcacgg 3399541 aatttacggt ttactttcgt tttatgctta cggatttgac gttccagttt gtttgttgcg 3399601 agatcaattg cgttgtacat atcctcgtta tgcacctcgg accgaagcgc cagatctgtc 3399661 atcggaatcg taacctcaac cttagactcc ttgtcattgt aaaacttcaa gttgacgttc 3399721 acatcagcat ccacgctatg gtcaaaatag cgctccagct tgccgatctt cctctcgaca 3399781 tgatccttta acgcgggtgt cacttcaata ttttctcctc tgatgttata gttcatcaaa 3399841 gaacgcctcc cttttattaa ggatatgtat ctatttctct tttacccttt acaattcctg 3399901 ctgaaacata aatcttttgt gaaaattcag tgaactttgt cgaattttgt ttgtatttgc 3399961 tctgttattg gcggttcgga ggtatatgta tatgctgatt gaacgaaaca aatacctcac 3400021 acacgcctaa ttgattaaaa agggttccat acattgatga atagacagca tccattttct 3400081 ataatgaatc agaaaatgtt cctttaaata ctcacagaac tcatgagagg gaaaagagaa 3400141 agagaccaat tgatcaaact ccgcaaaaat ttggtcaaat gctttcacac aaatttcagc 3400201 acaccgcgaa tccataatga agagaagtgt tgaatgtgtt gaatccaaat aaaaaaaggc 3400261 ttggatcaga tcttggtaga tccgatcccc ttctgttttt gataaattct cttcagcctc 3400321 tatcaaataa cacaacccct cttcgatggt aaaaagaaga tgataataag ctgataaaag 3400381 cgtataatct tcaatgctct tcaaggcact cacctattta cgcttgtcat aatatgtgcc 3400441 gtcaatcgta atgttgttat aagggtttaa atacgtcgta tgcatcacac gttttctttt 3400501 catctgctga agttctgttg cgattgactg cttcagtctt tccatttcct tcacaatcag 3400561 ctgatcccat gtcaaaataa gtttcatctg ctttcgctct tcttctgaaa gcggcagaga 3400621 tatctcctga atcagttcag accgtgtagc cacaaagtct tcaatttgct ttaaaagttc 3400681 atcgctttcc ggcgtatttt gtatgtgtga cagcatactc ttcgtctcag tgtatagttg 3400741 atctatatta ttcatgcgat cccgcctgat ccgtgccggt ccttccgctc actttgaatg 3400801 gcttgtttcc aagcatcgcg aaaatctgtt acataacctt caacctcagc cagcatgccc 3400861 gtatcatttt tgatatttgc ctgtaccaat ctgcgataca tataatcgta catcgcaccc 3400921 atagaagcgg aaagctctat gttacggtta agtgtaaaat ttaattcctg aataatattt 3400981 tgcgctttaa tcagattttc atttttacgt tccatatcat cattctcaat ggcctgagcg 3401041 gcaagtctta taaatttcaa acagccatta tacagcataa gcgtcagctc cccgggtgta 3401101 gccgtattca ctgaattttg ctgataggct gtatatggat tttggatcgc catgtgtcat 3401161 cctccaaatt acatttattg tacaagaagc tgtgataaat aggacgcttg ttcgttcatt 3401221 ttttgaatcg cagaatccat tgcactgaat tttgaataat agcggttttc tatggtattc 3401281 aatctgtcct gcatatcagt tatttcagta cttatcgagt ttaaattttt tccaatggaa 3401341 tagctactag ctcccattgt cgagttccca gctttagctt caatactttt cacagtactt 3401401 ctaagtgtat tagtaatccg cttcataata cctttatcgc tatagttact atcatttgtt 3401461 ccacttgtaa aaagattagc aactccttga ggatcttctg ctatttttgc tttcaatttc 3401521 tcttcgttaa tctctaagtg ccctcgcagt tggtaagcac ttgaagttgt gatgccaaat 3401581 tcagttaatt gataggtttt cccatccgca ttcacttgag tataaaagtc agtccgcatt 3401641 tggttcgtgc cagtgctgat gcttgaatcg tttctcagca atccgctttt cgccttctcc 3401701 tcccagagct ctacctcttt atcggacatg gcttcttttt gttcactcgt gagtggcgta 3401761 tagtctcggt atttttcttc tttcagcttt tcattcaggc tgtcaaccag ttcattgtat 3401821 ttatctacaa actctttgat ttggttataa atcccatcaa catcagtaga aacagatgtg 3401881 gtaacagggc ctgtggctgc agttgtattt ttaatcgaat aagtaacacc attcaccgtg 3401941 aaattgtttg tcagcttctc catttcaaag ccgttgattg tgactttggc atttgtgcct 3402001 tctttgtaag cagtaagctt attatcagca tccaaagaaa aaccaagctg accggacata 3402061 aagtcagctg tagcagagtc tgctgcctgt atgcttcctc ctgcacctgt tgctttagaa 3402121 gaaaacgcaa tcgtttctac gtactctgta ccattccaaa ttttatcttt aaatgctgat 3402181 actcctagat ctgagctgtt aagtttagaa atcacattat caatcgtatc ggcactcgtc 3402241 acactaatgt tcactgtttt tgctgttgtt tcgccaggcg caacaacgtt aaatgccaaa 3402301 ttgtaatcgc cttgtgtgta tcccgtataa ttgtttgcct tatacgttgc tgcagttgcc 3402361 aagctcgcca cttcaacagt agacgaagaa tttggcgcac ttacgcttcc tgtagcagtt 3402421 aacacagact cattagagct tgtcacagtt ttgctctgat acgtgctcgg atatgtcaac 3402481 gtatttttag acatataatc ttgcaattct tttatttttg agtttacttc acgatagctg 3402541 tcacgctgcc attcaagagt ctgctttttt tgtgtcagct tatcaagcgg cgctctttct 3402601 gtctgcatca gctttgatac gatatcatct atatccattc ctgacgccag acctgttatt 3402661 cttgtgacca tctcaaacca ctcctattct actttttttc atctacaaat aacccaagaa 3402721 attcagtcat agccgcataa aaatcaagcc accgttttgg tggaatttcg cggatcactt 3402781 catttgtaga gtcctctatt acctttacat agtattcatt taacttgtca tgaagctcga 3402841 acttcagatg aacttgcgaa ggttccaaaa gcttgttcat ttcccccacc atttcagcaa 3402901 gattggtata tgaaacttga tgaacaggaa cctcgttatc attatctttc tgattatgta 3402961 tttgagtatc ataacgatcc caaacaggtt gtaacgtagt gagcctttca atgttcaatt 3403021 gatcatcccc tatgccccaa tctatcgttt atatcgacta agtcgagata agattacaca 3403081 tatttttgga aaaaaatctt ctgttttaga tttcttgtat ggaaatacat ttataaaaag 3403141 ttagtggaga atccggttat tatatcatga gttagtgaca ggatgaggaa tgattaggag 3403201 atagaaattt aaattaaaag accctggcaa cgccaaggtc ttttttaaaa ttaacgtaat 3403261 aattgaagta cgttttgcgg ctgttggttt gcttgagcaa gcatagcttg agaagcctga 3403321 gaaagaatgt tgttctttgt gaattcgctc atctctttag ccatgtcaac gtcacggata 3403381 cgagactcag cagctgtcaa gttttcacca gaagcgctta agttgttaat tgtgtgctct 3403441 agacgatttt gtaccgcacc aagcttagca cgttgagaag aaacttggtt gatcgcttca 3403501 tcaacaactt tcaattgagc atcgaaaccg atatcagcag tatctgctgc attatctgcg 3403561 aattttgtta cgtcaagatc attaactgaa tgaagagctg caattgaacc atcagcttct 3403621 ttaattccaa gagcgtcagc acccatatcc tcaatattta cagagatttg ctgtgtagca 3403681 tttgctccga tttggaatac caagttcttt tgatttgcag gagtagctgt gtcaactttg 3403741 taagtgccat cgagcaattt cttaccattg aattctgtac gatttgaaat accatcgatt 3403801 tcatctgtta aagctgaaat ttcatcttga atagattgca aatcagttgc tttgtcctga 3403861 gttccagtgt ttccagcttg aacaactagc tcacgaacac gttgaaggat cgcatgagtt 3403921 tcagttaatg caccctcagc tgtttggata agagagattc cgtcttgaga gtttttagaa 3403981 gccatttcaa gacctctgat ttgtcctctc attttttcag agatcgcaag acctgctgcg 3404041 tcatctcccg cacggttgat gcgaagacct gaagaaagtt tctccatgtt cttttggctc 3404101 gcactgttgt ttgaagacaa acggttcagt gtgttaagcg ctgcaatatt gtggttaatt 3404161 ctcattgttt tgttcctccc tgaatatgtt gttaaggcac gtccttgtgc ccttattttg 3404221 taactggctg agtcttttgc gcctcctccc ggctacatca ttaatatcgg attgtctctg 3404281 attttgttaa tacaaaaata aaaaaatcct cacttttttt gtgaggataa tgcggagatc 3404341 acatcgctgg ataacgctgc tgcacggtta ttttcttcct gaatggtcaa gtaaatttct 3404401 ttcctgtgaa tatcaatatg ctttggggcg tcaattccaa gcttcacttg atccccttca 3404461 accgcaatca cttttacttc aatatcagca cctatttgaa tcgcttcgtt tattttccgc 3404521 gataaaacta gcatgattct cctccaatcg gatgctttgt cgtatatgag gagtcgtgta 3404581 aaacgacttg cttagccatc atgttcttgc gattcacaat aatgggagcc aataaattcg 3404641 cagtagactt ttcaaatggc tctgccatag tcaatattgt catgacttct acgtcttgaa 3404701 tattatcgat atccaaaagt tcagcagttg attcatcaag atcaaattca taattcttaa 3404761 aaaagataaa cggacttacg acgataaacg caagattttc tgaagtgacg gactgcagtg 3404821 ccacgaatgg agagtcttct gaaagcggaa gtatgacgaa ctgtttttct tctaaaaagc 3404881 ctggaatccc gctttcaaaa agaatgattt gttcttcttt tatgttcatt tggccatggt 3404941 acttcgtatg aatgatcatt gttcacgatc cttttctttt tacttttcgg gtgattcttt 3405001 cgggtattct acatctatat ttaaatcagg gtattgaagc atgtcaacct taacatttcc 3405061 tggcgtatat tcaacaattg gcttatgcgg ctcagcctga ataacaggct ttcgcggcgt 3405121 aatctgcaca tcaagctgtg acggagtata ttgtattttc accctcgaaa gagaaggagc 3405181 ataattttcg cctaattgaa tttggtgcat ttcagagttc ctccttgctt gtgaagcgat 3405241 tgggttcccc ttattttcaa tcttcataag ctcgtcgcct tcttctgcag tgcgtgctat 3405301 tccctccatt acatcctcat gcccttgttg ggcggcttct tcaattctct tgaaaacatg 3405361 ctttctgtct aattcttccc atgcttgtgt ctggtcaatc gtgagttttc caggtgtcac 3405421 cgatatttcc atttccgcac tcggctgttc gatctctaga tcagcttgag gctgctccat 3405481 ttttaagctg gcaggcgtcg ttgttaaacc aatttttcct tgaacactat gcataatcaa 3405541 tctgggaatc tgcatcactc tacctcctga actataaaaa aagcgaactc ctaagagccg 3405601 cttactttaa aaagtcaatc aatgtaggct gaacaatttg cgcattaacg gccagagtag 3405661 ccctgtgcac actttgctgc gcaataaatt cagttattac ttcttccagt tctacatctt 3405721 cattgtctga taacactttg gtagctgttt cttcttgcgc tgacagtctt gtattaacca 3405781 gttcaagacg attatatctc gctccaagat cagatcgttc agcgctcatg ccgtcagaaa 3405841 aatgatcaat atcatttaaa acactgtcca tgccatctag cgaaccagaa tttagtgctt 3405901 tctcaaaaga atcaagcatt tcaaatacat tctgcccgct ttcagaagtg cctccaaaag 3405961 ctgactttgg atctgaattc actttcaatg acatattatt tgatatattg actacgacat 3406021 cagctgtatc agaaattgta taagttccgt ctccgttatc tgtaaccgga ggcttatctg 3406081 aatttgtgcc attaaagata tatctgccgt tcacttgtgt attcgcaata tttaaaagct 3406141 gttcctttaa ctgctttacc tctacgccaa tcgcttgccg ctccggctcg ccgtttgtat 3406201 cattttgagc ttcaaccgct aattctctga cctttgacaa gatgtcaatt ccttctgtaa 3406261 tgtttgtttc tgtgttttcg agccaggtaa aggcttgaga agcattgctt ttgtactgct 3406321 gcacttgaga cagttgcgta ttatacttta agcttttcat tgctactaca ggatcgtcgg 3406381 aagcttttga gatttttttt cctgaagaaa tctgcgactg gagtttatcc agcttcgagt 3406441 agcttgaacc gatatatctc agtgagtttt gctgtatcat gccttgtgtt actctcatgt 3406501 gactctacct accttcctcc aacacccatg ccgttgatca ctttatcaag caattcgtct 3406561 tgtaaagtca ccattcttgc agctgcattg tatgcgtgtt ggaattgaat catattcgtc 3406621 atttcttcgt ctaaagaaac tgcgctcatt tgctgacggt ttatgtcagc atcattcagc 3406681 tgtgtttctg tattagacgc cagtcgatta gcctcttgag cttcgatccc tagctcgcca 3406741 atcagacccg cataataatc taaaacacta gtttctttac cgttaatggt tattttaccg 3406801 gttaaaacat ttgctaattt tgtagcattt gcgttatcgt tggctgcgcc agtcagtgag 3406861 aaagcaatgt ttgcgccttt tgaatctatt atgctgtcag ccactttgat cttgcccgcc 3406921 gcgcccttgg caggttcagt ttcaccgcca gtaaaatcaa aaaagtctcc gccttgttca 3406981 ccgctcttgg tcacaccatt tctgtgcact tcattgaaag ctttcgcgaa ttcaagcgcc 3407041 atattgtcaa gatcagaaag catttccggg tatacgccct tttcttggcc atctgctgtt 3407101 atatacccat aagactctat aaaccctaaa agggatccct tgctgctaaa ggactccgcc 3407161 tgtacagctg tatccccgat tgaaatactt gatactaacc cagtttcatt atcatagttg 3407221 gctgcaagtt ctgaaacctc gtaattttta ccgtccaaaa cagttcctag cgactgttta 3407281 tttttatcaa ggatttcaat tgatacagtt ccttcagcag atgcaagtgc attcccgcct 3407341 gatttgttgt agctgacttt gatatcaacc attgaggata atttatcgat cagcaaatct 3407401 cgctggtcat ataagccatt cggaagaagc ccgaccggct ctacttgtgc aatttgctta 3407461 tttaaactgt ttaactgaga aagcagagaa ttgacatcca acacagttgt atttagctct 3407521 gcttttaaat tcgattggac atttgtaagt gattcagaaa tataattaaa cgtttcagct 3407581 acagcttgtc cttttcgagc aacaacagaa cgtgcacttt cttcatttgt attattcgat 3407641 aattcctgca gggaattcca aaacgaattg agcacactgt tcaagccgct gtcatccgtt 3407701 tcatttaaaa cgccttccat ttgggacagc gcttttgcct tcgtgtcata gtatccggca 3407761 ctgttgtttt gaagacggta ttggtagtca agaaagatat ctcttattct ctcaactgat 3407821 tttccttgaa cgcccgtacc catttgtccc gctgtttttt ctgcattttt agatacagca 3407881 gggaaatagt cagttgcctc caatgagacc cgctgtcttg tataaccatc agtattggca 3407941 tttgccacgt tatttgcagt agtgcttaac gctgcctgct gagcgcttaa cgcccgcctt 3408001 gcagtttcaa gccccataaa ggtagatgtc attttctgaa ttcctttctg ctaagctttt 3408061 gaatcaaaca gtttcatttt gctacttttc ggcagctcag ctttaattga tttgctgtaa 3408121 ttgaagttat tttccttagg aaccagcata tcgtacgaaa tagagatgaa ttgcagcgcg 3408181 tctcttgtca gctgcctatt catctcattt acttttttca gacgtccgag aacttgagaa 3408241 agagattcgt atagttgttc cagctcttcc ttttcactgc ctgaggtttt ggcgatacat 3408301 gcggaaatag tattattttc gctatatccg agaaaggccg aagttgtttt gatccggtca 3408361 tcttctgtct gcgtgattgc ttgaatatat ttttgctctt ttgtcaaaat gttagaaagc 3408421 tcttttgttt tgccggcttt gagcgcttcc gtcttttctt cagacagcgt gagcaggtgc 3408481 tcatgcagaa cgcaaagtcg cttcaattgt tcaataattg ccttcgctga catgggcttt 3408541 ctcctttttt attgcttttt ataaaaatta atcatatttt tcgcaatatg atttgcgtct 3408601 actttgtatg acccgttttc aatttgcgct ttaagctgcg caattttttc ctgtcgtgaa 3408661 ccagtgactg cgtcggatgc atgttgcatt tctttagcct gtgatgaaat ttcaatttta 3408721 tcttgaggtt gtgcaacagt tttttgcacc gcttgcttat cataattttt ttgatatgga 3408781 ttaacggatt gtgttccaaa ttgattgatt ttcataggat tcctctcgct ttccgttgca 3408841 gtctttaaac aatcttaacc cttttatcga ctgcgttttc agttagttta gggaatcagc 3408901 tgtttttggt attataggca tagtatgtgt cttttttact attttctttc tcgattttca 3408961 gagcatcctc gtggttcaaa tgatccattt gatccttaat atcagactgg caagccttgc 3409021 agaacttgcc ttctctaatc gatgtcccgc acctttcaca agggtatgcc aaattaggaa 3409081 gatgagtgat ctgaattcgc ttctgcctga tgaatttcaa tatcagctct tcttccacac 3409141 ctgtttcctc agttatccgg ctcaaagttg attgccggtt ttcctgtttt cttaaaaatt 3409201 tatagacagt ctcaaatgat ttttcttctt ccttaataca cgcctgacat acggtttgca 3409261 gctttgtttt taaaaataaa gcattgcatt tcggacaatt agccagttct cccatctttt 3409321 tttctcctta ttagataata tgcctgtgtc aatttctagt gattatatcg gcataaaaac 3409381 agaatcattt agcttctgat caaggtaaaa gatgacactg aagcggcttt tcctttttct 3409441 aataagcagc gggctgcgaa gtgcaaggtg gcgcctgttg tataaagatc gtctattaaa 3409501 atgatattca taccttctgc tgaattattt tttgtatcaa aaatgcactc tgacagcagg 3409561 cgttctgttt tctttttctt tgactgtttc tcattattca ggcgaatgag gggatggtgg 3409621 gaaggccggt ctaaacattc tgccaagaga tgtgcctggt taaatccgcg ctcttcttcc 3409681 cgttccttgc tcagcggaat aggtacaaga acaaaatgct tatcggggta aaccttagaa 3409741 aaggttgaag aaaaatcact tttaaatgca tttatgattt ctgcatctcc tctaaattta 3409801 aaacgggaga gcgtttcttt catcatatca ttatatgtgt aaactgaacg gttttgacgc 3409861 aatagcaaac tgtctctgat ccttgttctc cacacctcgc aatccctgca tacggcatga 3409921 acagattgag gtctgccgca cagggggcag atatgtcctg tgattttctt taatttgctt 3409981 ctgcaagaat aacaaacctt ttcatcaggc tttagtaaaa aaagggctct ccatgtaaca 3410041 tcttgagaaa attgcgaatc acataataaa cagatcagtt tatgaatgcc tcctcctgct 3410101 tcgtttgaca taaatcgctt ggactctctg aaactactgc agcagattca gccaaaatga 3410161 caagcattgc tgtgtttttt tgtttatcta ccagctcagc tttcgtatat gcgatctttt 3410221 taaaatcagt aacgtaggat ggactcactt tgtttaaaga aagtgccaat acatcgtttt 3410281 ggcatacttg gcaagtacag gccatatgaa gctggtccat atatcggtcg agcagttctt 3410341 tcattacgat ttcttttgaa ttgacaagca tttttacagc tcctcatcat cggttatatg 3410401 agtatactgt accacgtttt caaataatgg ctagtctgta cattcaactt ttgctgccaa 3410461 ttcattcatt tcttttatat gctttcttgc atcgagcata ctctttgttt tgccgaagtg 3410521 aaagtaaatg acatcgccgt ccgcatattc tttatgccgg ccggttcttc ctgcaatttg 3410581 aacaagtgcg ctttccgtaa agatagacga ttccgctcct agtacacccg tttgcacctt 3410641 ggggactgtg acgcctcttt ccagtattgt tgttgtgatt aatagatcga gctgaccatc 3410701 tctgaattgc tgcactttct cctttctatg cttgtcttcc gcgtgcacag atgcggttcg 3410761 gcaatgaaca cctttaaagc acgcagcagc cttttccaga atagaaacgg aaggaacgaa 3410821 taaaaaaaca ggcctccctt cttttacatg aaactctatc catcttttca ccgctggcgg 3410881 aattttattt cggtttaatt tcttcttcca gtttccacac catacaaagc gcggttcggg 3410941 taaaggtttc cggtggtgtc ttgcggggat gcgaactgaa tgtaactgtc cgttcagtgc 3411001 ttttcttttt aattctttag gaggtgttgc acttaaataa acgagggtgc tgtttttctt 3411061 tcttgctttt tgaacagcga attgaagggt ttgatcagca gaatatggaa aagcgtcaac 3411121 ttcatcaatg atcataacat cgattgcatc tttatatcgc aaaagctgat gcgtagtgga 3411181 aatcataagc ggagatagcc gccctttgtc atcgcttcct ccgtaaagcg ctgaaatgtc 3411241 agcaccctga aaggcagcct tgagtcttgg agcaagctct aatacaacat cggtgcgagg 3411301 tgttgcaata catacacgca gtccttgatt taacgctgat tctataccag gaaacagcat 3411361 ttctgttttg ccagcgccgc aaaccgccca gatgaggagc tcttcttttt ttgatattgc 3411421 ttcaattaaa acattggcgg ctttttgctg tccgcttgaa agcttgccat cccatgtcag 3411481 cttaatagac ttccagtttg attcattttc ctctttccat gaatataaag gaacctcctc 3411541 actcactctg cccatcatga cacaggaacg gcaatacagc ttattctttc cagatgagtg 3411601 ataaaaagaa aaataccgct gatcagtttg tccgcaccta ttacatctat atctccgttt 3411661 atttatggat atagaatttt cagcagtgat atatccattc ttgatatgcc attcaatcat 3411721 ctcatcggaa aatgagagct cagtcctgag caaatgacgg cttcgaagcg tctgctgcaa 3411781 ttcttttgaa aaggaactgt ttttttcaac tggcacattc acatagcacg cctcctttcg 3411841 aaacagtatg cctgaatgaa tattttctgt ccaactatta aaataagaat ataaaaaaat 3411901 ctccgctcta aaaacggaga tttggcctta tttaaaacac cagcaaattc ctaacgcacc 3411961 ttcacccaaa tgagtgccga ttaccgcgcc aaaatagctg ttataaaatt caacatgagg 3412021 atattttgca gaaagctctt caatgatttt cgctgcttct tcctctcgat tagcgtggat 3412081 aacagcagct cgcataggca accctttact cgcatcttcg tctaaaagct cataaattcg 3412141 cgaaattgct tttttacgtg tgcgaatctt ctcaaaaggc acaattacct tattgtcaaa 3412201 atgaaggata ggctttacct ttagaagact accaatgaag gcttgggcgc tgcttaatcg 3412261 cccgccgcgc tgaagatggg ctaagtcatc taccataaaa taagctcgaa ctgttttttt 3412321 catttcttcc agttctttta taatatcttc cggcgatgat gctccgtttt tgattaattc 3412381 agcagcttta agggcataaa agccttgagc caagcagctg atctctgagt caaatggata 3412441 cacatcaata ttgtcgacca tcgaatcagc cgctgctgca ctgctgaatg ttccgctgat 3412501 cccgctggaa agatggatac tgataaccgc atcataagac ttgccaagct cttcatacaa 3412561 cgcaaccagc tcgccgattg gcggctgaga agtcgtcggg agctcattat gttttttcac 3412621 ttcttcataa aagcttttcc agtccaactc aatttcttca cggtaagtct cctccctaaa 3412681 aacaacctgg agagggatca tatgtatctg atgttgttca cgcatttctt tcggaatata 3412741 tgccgtgctg tctgttacga ctgcaatatt catagcttcg atacctgcct tattgcttta 3412801 taactctatt gtaagggaaa cggcagccta aaaaaagacc tgcctagtaa aaggcaagtc 3412861 tcctattata ctatctcatt tctacccagc catttttaat ggcgaccaca acggcttgcg 3412921 tccggtcgtt tacattcatt ttttgtaaaa tattgctgac atggttttta acggttttct 3412981 cactgataaa caatgattca ccaataccgc ggttgctttt tccgtctgca agcatctgca 3413041 gcacttcaca ttcccgccta gttaaaatat gtaatggtct gcggatttca gggtaaacct 3413101 catgttgagg gtgtgcagaa actccgcttg ttgcaaggcg gcggaattcg ttaacgaggt 3413161 tgtgagtaac cttcggatgg aggtaagatc cgccctcagc cactacttta accgcttcaa 3413221 ttaatgtatc agcatccatc tctttcagca gataacctct tgcacctgtt ttcagggcat 3413281 gtgttacata attttcgtca tcgtgaattg atagaataat tactttagat tcaggataca 3413341 gctctacaag ctgttttgta gcttccacac catttacgtt tggcatattg atatccatga 3413401 tcacaacatc aggatgatag tgctcaacaa tacgagccgc ttcgtccccg tcatcacctt 3413461 cggctaccac ttcaaaggta ggttcaaaat ccaatatccg tttaacacct tcacgaaata 3413521 actgatggtc gtcgataata acaatgttta ctttagtcac aagccacgcc tccttgtatt 3413581 attgttctat atactctagc attcggtcaa tatgcctttt ggctctattt tacaaatcat 3413641 agtcaaagag ataacggaac cttaatcata ataaatgtcc caagacctat tttcgaatct 3413701 attgtcatcg ttccttccaa taaatctact ctttctttca tgcccagcaa gccgaatgat 3413761 ttgtttttct tctctttcgc ttccttcagg tcgaaccctt taccgttatc ttttatcatt 3413821 aaaatcacaa aatcctttgt gatctcaact ttgactgtaa tttcttcaga ttcagaatgc 3413881 tttagcgcat tagacacagc ttcctgtgcg agcctgaaga gcgcaacctc aaactgaggc 3413941 gctagcctct gatcctctgt ttctccaatg cactgaaaat gtattttgac cttcccgtta 3414001 tattcctcgg ttgtatatag atattttctt aaagttggaa tcaggcctag gtcatcaagg 3414061 gccatcggtc ttaaatcata tataatcctt ctcacttcgt aaagggcatt ccgaacattt 3414121 tggcggagat ttttaatttc ttggaatccg tcctctgcgc cccggtcacg gaaaatccgc 3414181 tcgattaatt ccgatctcat cataacattc gccagcattt gagcgggtcc gtcatggatt 3414241 tctcttgaga ctctttttcg ctcttcttcc tgcgcctcaa taattcttaa gccgaaatcc 3414301 tgttttgcct gagcatcagc aagaagcagt ccaacttcgc gcaaatcctg attcaagtag 3414361 ttgagcacaa ctgtaatttg gcttactaat gattctgacc gctcaatgat ttcctgaagc 3414421 cctagcaatc tgcgctccaa atcgtcccgc cgttcgcgca attgcttctc acgctgctgg 3414481 atcatcgtca attctacctg cagcttatgg gctttttcat aagcattgcg gatttcctct 3414541 tcactgaatc tatgaaaatt acggctgacc tcggataaac ggtttctcgc atggcgagtt 3414601 tgcacttcaa gtttatcgcc aagctcaatc acttcataca cctgctgttt aatttgtttc 3414661 agttcttcga ccagctgttc atactgctgg cgtgactgct ccccgatttg aaaaacctcg 3414721 tccttgctcc cgtcaacggt tttcagcatc ttcatcaaaa tagaatccag cactttggaa 3414781 tccatctttg ttttattcat aatttccctc cgtcacggcg ttgtcatata tttttattat 3414841 aaatgtaatt gatctgcaaa ttatgtcgaa ttataatgaa agaatgcgta tattctagaa 3414901 aaaaacattt ttatatacta tctactcttt atgataccaa aatacgcaca aaaattctaa 3414961 agactgtacg aatttgtata ggcagtcttt tatgcttagc aggagggtca gctagcatgc 3415021 tgcacagcta ttttactgtg aaagaagcgg gagaacacga gattgttata gaaaaatcgc 3415081 gttttatctg tcatttaagc cgtgtttcta ccgaacaaga ggcacaggaa tttatacaga 3415141 aaataaagaa acagcactgg aatgcgactc ataattgctc ggcttatgtt attggcgaga 3415201 atgatcatat ccaaaaagcc aatgatgacg gggaaccaag cggtacagcg ggagtgccga 3415261 tgctcgaggt tttaaaaaaa cgcaggctga aggatacttg cgccgtcgtt acacgctact 3415321 tcggaggcat taagcttggt gctggcggat taattcgcgc ttatgggaaa tcagtgtctg 3415381 aaggattaaa tcatataggt gttgtagaac ggaagcttat gcgaatcatg catacttctg 3415441 cagattacac atggcttggc aagattgaaa atgaattaag ggagtcacaa tttctgttaa 3415501 aggaaatcca ttattcagaa aatgttgaat tcgaaacata cgtggaagaa aaagaaacca 3415561 acgctttttc tgaatggatg acagaactga caaatggaaa gagtgatatt aaagagggag 3415621 agttgacgta tcttgaaaaa gccgtcaatc acataaagga gactgaataa tggctgaacg 3415681 cgttagagtg cgtgtgcgaa aaaagaaaaa gagcaaacgt aggaaaattt taaaaagaat 3415741 aatgttattg ttcgcccttg cactattggt agttgtaggg cttggcgggt ataaacttta 3415801 taaaaccatt aacgctgcgg atgaatcgta cgatgcccta tcccgcggga ataaatcaaa 3415861 tcttcgcaac gaagttgtag acatgaagaa aaaaccattt tctattttat ttatgggaat 3415921 agaggattac gcgactaaag gacaaaaagg gagatcagac tctcttattg ttgttaccct 3415981 ggatcccaaa aataaaacca tgaaaatgct gagcattccg cgtgacacac gtgtgcaatt 3416041 agctggtgac acaacgggaa gcaagacgaa gatcaatgcc gcttacagca aaggcggtaa 3416101 agatgaaaca gttgaaactg ttgaaaactt cttgcaaatc ccgatcgata aatatgtcac 3416161 agttgatttt gacggattta aagatgtgat taatgaagtc ggcggtattg atgttgacgt 3416221 gcctttcgat ttcgatgaaa aaagtgatgt agacgaaagc aaacggattt acttcaaaaa 3416281 aggcgagatg catttgaacg gcgaagaagc cttagcatat gcccggatga gaaaacagga 3416341 taaacgcgga gactttggcc gtaatgacag acaaaaacaa atcttaaacg cgctgattga 3416401 ccgcatgtca agtgcaagca acattgctaa aattgataaa atcgcagaaa aagccagcga 3416461 aaacgttgaa accaatattc gcattactga aggtttagcg cttcagcaga tttacagcgg 3416521 ctttaccagc aaaaaaatcg acacattgag cattacaggt tctgatttgt atttagggcc 3416581 taacaacaca tattactttg aacctgatgc tacaaatctc gagaaagtca gaaaaacgct 3416641 tcaagagcat ttagattata ctcctgatac aagcactggc acttccggta ccgaagacgg 3416701 gactgacagc tcaagcagtt ctggcagcac tggcagcact ggcacaacaa ctgacgggac 3416761 gacgaacgga agcagctatt cgaatgacag cagcacaagc tcaaacaaca gtacaacgaa 3416821 ttcaacaact gattcatcct attaaaaaat gcccggtcct tttagaggat cgggcatttt 3416881 tgcgcagaaa aaaactccgg cacataagcc ggagttttta attccttttc accagccgtt 3416941 tataaaactt tgtaaacggc ttaaattttt cattcacgag tcctgtcact tctgctatga 3417001 tttgcataaa aataatcaaa atgaagataa taaacaaaga aagccaaatt gtggcacttt 3417061 taagtacaat cgcactgata ctgaaaataa atccaattaa ataaataact aagaccgaca 3417121 tccgatgtga aaggccaaag gccatcagtc tatggtgaat atgcgactta tcaggcgctg 3417181 aaatcggctg tttgtttaat attcttctga tgatagcaaa tgttgtatca aaaatcggta 3417241 cgcctaatat aataatcggg ataacgatac tgaacaatgt gacactttta tacaggccta 3417301 ataatgaaag aatcgagata ctatacccta aaaacagtga tcccgtatct cccataaaga 3417361 tttttgccgg atggaagttg taaaacaaaa accccagcgt gctggcaata acgactaatg 3417421 agagtgacag aatgagcact tttccgccgg atagcgccat gacagcaatc gttgacaggc 3417481 cgataacaga aagaccggca gcaaggccat ccaatccatc aatcaggtta attgcgttcg 3417541 tgatgccgac aatccataat accgtcagcg gataagccat ccatcctaac tcaaatcgtt 3417601 ctgttaaaaa aggtactgag aaaaagtcca tttttaagcc agtgcttaca atcataatgg 3417661 ctacacctaa ttgaatcaaa aacttaactt ttgcacttaa ttgatattta tcgtcaagaa 3417721 tacctaacac aataatgatg aatgctccga ctgtaattgc cgtcatcctt gtttctgtgt 3417781 aaataccgga tgcaagcacg cctgcaacca ccccgataaa tatggccagc ccgcccatgc 3417841 ggggcatgat tttgtcatgt acttttcgat tgctgggctg gtcaactgca cctattttaa 3417901 tcgcaatcct ttttacgatt ggggttatga ttaaaactgt cagcagcgag acaataaacg 3417961 caacaacaat gcgaatcatg cgttcgtcaa gcataaagaa gtctcctttg gaattaaatg 3418021 aagtctttat ttatatagag aaccgttcct tccattatac cttctcctta gttattataa 3418081 caagcttcat caaaaagaaa cacgtataat caaaaaacgc gcatcccaat ttataggact 3418141 acgcatgttt ttgaatccct gtatatttca taatttgtct aaataagcaa ttccaatctt 3418201 gtgtccgggc gatgtttcgg cgcatttctt tataggtctc gtctccgttt tgaccgagaa 3418261 ctttttcaca agcggctata aaatcaatcg gatgatcgcc ctctacatat tcgtatacat 3418321 acggcttttg catttttgag gttgacggaa gattagtgcc tacaacaggt tttcctgccg 3418381 ctaaaaattc aaatagtttc agcggaaaca cagcttgatt atacggtgat tgtttatatg 3418441 gcataatgcc aatgtcgata agctccatat aatgaggcac ttcttttgga tctgccggac 3418501 cggtccatat gacattggga agcctcagca gctcttgaaa cgaaacatca ccattggtgg 3418561 catccgggcc aacccataaa aatgtccaat caggcttttg cagtgccgct tctttaatca 3418621 ttttaaaatc gagcttcggt ttaatcccgc caataaaacc taacactatt ccttctctcc 3418681 cctgcagtat actgcgatcg ggagcttgtt tatttgcaga aaacagctca tactccacac 3418741 cgttttccac agtatgaacc ttttctcgtc ctgcagtcag ttttttgtct acttccttgt 3418801 gaagataatc tgatgaacag gttattgaat ctgctcgttg tataattctc agctctgccg 3418861 atttaatgac ttttcgccgg aattcagaca gcagatttga tcggccgctg atcggcgcag 3418921 cccataggtc actgcagtca taaatgacct gatcccaaga atacagcgaa gacagcagcg 3418981 ggaatccggg aaacgtgtac cataaacagc agcgttcacc gtttgcagaa gcaggtgtaa 3419041 gctcatcgag taatggggag agcttatgtc tgtaaaagac atctgtatat cgtccgaaac 3419101 gaaacatttt tttctgcagc aggtctttga cagcgaattg cctgatgcca gaatggactt 3419161 cctgaaactc tttcccttgg gcacgcggag ccggacatac ccaaataact tccttcgttt 3419221 cctcctgagc agctaaaaat tctgccagcc ggtgccttct gtatctcaat tggtcttttc 3419281 cccattcagc agtggcaacg atgacatgaa tgattgcttc ttttgtttcc accttcatca 3419341 ccttttctct ctgtttgcag ctataatctt tttttcaccg cgttttttgc atattgaaca 3419401 aaacaccatg ttgctttcat aaaatgaagc cgttcgatct ccctgtagac aaaccacgtt 3419461 tttttcgcag ccttccattt gttgctggaa attgaattat tgacaagccg atattcagcc 3419521 aggcattcat tcattccata ggcagtaaat ccttttttta aaagagacag ccatgtggct 3419581 aagtcctgtc tcgttctgat attcggcatt tggatctgtc ccgtttgctc cctgtcaatc 3419641 atcaccgtca agcagccgat aattgtattt ttcagggcgt catcgtacgt caggctttcc 3419701 ggcgcatgaa taaatttatc gagcggggtc ccgtcctgcg ccattaagct gtagcccgtg 3419761 aaagagaacg cacaggagcg ctccatcata aactcaagct gcttttccag tttgtctttt 3419821 ttccatttgt catcactgtc caaaaatgct acgtagcgcc cttgagcgcg ttccaacgct 3419881 ttgttgcgag caaccgcagc tccggagttc tcttccagat acaccacatg aattctttcg 3419941 tctatttttt catactgctg taaaatgtcg cgggtcccat ccgttgagca atcatccacg 3420001 ataatcattt cccaatgagg atggctctga tctaataccg aatgaaccgt gtcttcaata 3420061 tagtcacgcg cattatagga aggtgtaatg acagatacga gaggtttcca attggtcatg 3420121 atcacatctc catcgtatga ttttaaaagg attctctgaa aaattcagga atgacaacga 3420181 acataaaggc aatcgtaagg ccaatcataa cgccgagaac tgctttcttt ttcggagaca 3420241 taccgccgcc tgctgtctca cttacggttt cggaatcagt aacacttgcc gctttcaggt 3420301 taagctgtgt gtttttgagt tcatataaaa atctctcttt atccactttg gaatcctcgc 3420361 tcaccgactc gccttcaagc gcgtctatgc tgctgcggat gacggcttct ctttctgcat 3420421 acagcttttg atcgtttttg aggaaggtgg aggatatggc gtttaagaca gattccgttc 3420481 tatccttatc ctcgtcacta tagcttaaag tcagtaacga tttggattcc gtattgattg 3420541 taagcttctc tttgatctct gctacatctt catccttttc atcaggaagc gcctccttca 3420601 aaaaggagtc gctctttaat agaagcggaa tctcttctgt gctgttataa accggatgat 3420661 catagctccc cacagccaaa gtatcttcag ctgtatagct cttttgatca gcgatctgtg 3420721 acggcaggat ataccccgcc gcacctaata taattggcac cgctatgatc caaatgatat 3420781 ttttttttat gcgacgggct attcttatca atatatcgtt catataagtc tccctgcttt 3420841 ttgtagtctg tttatctgta catcggctca ggcatttgtc tggatcgcct taacacattc 3420901 acggcggcga tgacgagcgc cataaacacc caatggaaaa ataaatttga aacagagctt 3420961 gggctgatac ttgataccag gaaactgacc atagcggtaa taagtccttc tgtgatcagt 3421021 tttgactgat tttctaattt tctttcataa aacttgtaaa gcacccatat gaggtaggca 3421081 taaacggaca aatatcccag catgatgaac aaaccaaaat tagcaagaat ttcaacaagc 3421141 cagttatgca cctctgccac attgtcagta tcatatacag cataatgctc aagataatag 3421201 gatacatttc ctgccccgac tccgaatccg tatgaatcaa ggaaaaaatg ccaagcgttt 3421261 ttcagcagat ttgcccgagc cacatttgat ggaagcctgt catgaaatga atgcagcgtc 3421321 tgcggggcca gaaacagctc ccaaaacttt gaatagattt tgctggcgaa aagaactgcg 3421381 aaaagagcaa ttcccgccgc cgacagccat atagccattc tctttaaaac aggcggcaat 3421441 acaatgaaga tgtagacagc aatacctgca aaaatgccca gaaggctggc tcttgaacca 3421501 gtggcaaaaa ttaaatacaa cgcacagagc gagagcacaa ggccaattgc cttgatgtat 3421561 ccattcttaa tgtttttcat catcgtgatg taaaaaaaga agctgatgga taaaaaggtc 3421621 gcaaagtcat tttgattaaa aaagaccgat gtcggataat gctgcttgta ctccggtccg 3421681 ctgtacaatg tggaactcgc aagatgatgg tgggtgatat gattgtaaaa accaatgatc 3421741 atcagaaata ccgtcatcac cagccaaatg gcataaacaa tcatcagccg ctccattttt 3421801 tgcacgtaca tgacaataag ataaatgaag aagatcccca ttgccaataa ggctaaatac 3421861 ttgaggccaa ctgttaccga cttggcccac agcagagaaa caaggccata tataaaccaa 3421921 aaggcgaaaa agagtaaaat cccttttact tgcagcccat gccatctttc aatatgggtt 3421981 cgattccgaa ccatgccgaa aatatgaagg caacccgctg caatgagcag aagccggtaa 3422041 aggaacaaac tgaaaaatcc aagatgaatg gcaaaaaatg cattatttaa aaaagtgcag 3422101 gcgatcaaaa tatagattac agccataaag agccgttctt ttgttgtaaa tgcggttgca 3422161 agcgtcagta aaaacaggcc aattgccaac accgcaagca cagcagccat ctgcatgaaa 3422221 cctatatctt tatggatggc tcccagcaat aggacgactc caaatatagc agcggccagt 3422281 aacgctagcg tatggaccgc tgatcgtttg atactcacat gtttaacccc tttcctgatg 3422341 tttcaggagc cggcggccga gcctagcagc cggcagcttc aaccaagtaa cactttttct 3422401 ttttataaat tgacgcttcc caagtcttta gccaattctt caagcggcaa gcccggaaaa 3422461 tacttgtcag agggttccgt tccccgaaca gcgggacggc cgatagagtg ataaatgtat 3422521 ccggctgcct gcatctcttc aagtgaaaat aaatttctgc cgtcaatgat gactggctgt 3422581 tttaagaggg ttttcacttt tacaagctcc atttctttca cttccggcca atccgttaaa 3422641 atcaggcatg catcagtgtc ttccatcgca gcatacacat ctgtgtaata ctcgacctgt 3422701 tcgccaagga tcgctgaagc ttcaggaata gcaatcggat cgtatgcttt tacatgggcg 3422761 cccagctgct gcagcattgg gataatatca agcgctggag cggatctcac atcgttcgta 3422821 ttcggtttga aggctaatcc caggactgaa atggttctcc ctttgacgct tcccataaca 3422881 gtcaaaagtt tatctacaat atgaacacgc tgcttttcgt tcgtttcaat gacagcttcg 3422941 atgagcttga atggatagcc tgccgatttt gcgatttgaa gcagcgcggt tgtatccttt 3423001 ggaaaacatg aaccgccgaa tccaatacca gctttaagga actttctgcc gatacggctg 3423061 tcaagaccaa caccatcagc aacttttgaa acgtctgcgc cgactcgctc acaaatgttt 3423121 gcgatatcgt tgataaagga aatctttgtc gccagaaatg cattcgcggc gtatttaatc 3423181 atttctgcac tttctaggtt tgttttaatg acaggagcat ggaatggctg atgaagttcc 3423241 tcaatgatgg cagcggcttt atgacttgtt gaaccaatca cggcacgctc catattcatc 3423301 gtgtcatgaa tcgctgaccc ttcccgaagg aattcagggt tagatacaac atcaaatgag 3423361 tatctcccct ttgaggcttt ttgaacgata gattgcacca gtttccctgt tccaaccggg 3423421 actgtgcttt tatttacgat cactttgtag ccgttaagat gctcaccgat tgttttcgcc 3423481 gccgctttga cgtacgttaa atcagcttca cctgttttgg acataggcgt tccgactgca 3423541 atataaataa tatctgaggc ccgaatggca gacgggatat cgttcgtaaa ggtcaggcgc 3423601 tgatccagca catttttttc aactaagtct gcaagccctg gttcatagat tgggattacc 3423661 ccatttttca ggcttctgat ttttgattca tcgatatcac agcaaacaac tttattgccg 3423721 atctccgcaa agcaagtgcc tgatacgagt cctacataac ctgttccaat gacagctatt 3423781 tttttcacag cgctcaaccc tctcctgtaa aatgatcttc caatttataa tggtcgcagt 3423841 gtcttacgat taaacggacg ttttcgtgac cgtctgatac tgatgatgca aggccttggc 3423901 gttttttcct gcgtcaaatt gagcctgcac ggtttcatac aagtcatctg ctacttccgg 3423961 cttccatatt tgctcatgtt cgtaccgagt gatcgcttcc gccaaggctt gagcggattt 3424021 cggtttaatc agcagatgtt ggtgctttcc gaataaagac gacactccgc caacatccgt 3424081 acaaataaca ggaaccctta gcgccagcgc ctcaatcaca acagtcggca tcccctcact 3424141 gtaagaagga agtacgaata gatctgccgc aagtaaatag tctcttacct gatgattcgg 3424201 gacttggcct gtgacgatat gccccttctg cgtcagcgtc gattttgcgg gaccatcccc 3424261 gacaaagact gccttaggag agtcctgcag cgattcgatc gcttcagaca gttcaaaaat 3424321 gcctttctct ctgaccagcc ggccgacata gacagccaga cgctgatcga gcgggagtcc 3424381 gagtcttttt ctgatttcct ctttcgtctc ctcattcccc tgaaaacggc tgagctgtat 3424441 gccgattggc aaaaccgagc tgtcaaagcc cgaaagcttt ttggcttctt cctgaagctt 3424501 gtggctgact gctaaaacaa ctgacgcaga acctacggca cgcttgaagg ctttaaacgc 3424561 acctttgctg taatgcggat agacattcac atcactgcca tgcaaggtca ggacataagg 3424621 aatttgcgct gactctgaca cgactgccgc agccccgccc gatggcatgg caaaatgcgc 3424681 atggatcaga tccggatata ggtcgcgctg tttcattgtt tttaaaacgg ctgatgcgat 3424741 tctccgatga ggctgcgccc acttcagctg gccgggaact gcccgataga aaggccggta 3424801 aaccggtatc ccctttctaa tctcatactc cggtctgaca tccttttttc gatatgtctt 3424861 tttcagcatg cggacaggtg ctgaatgaaa aggccgtggg catatcacag tgatatcaag 3424921 cccgagtttt tgcagctctt gcacctgtgt ctcatgaaac acaccctctc cgggtttcat 3424981 actgctcgga tatacgcttg tgatccacaa aatcttcatg acaaacgtcc ttttcttagt 3425041 agtttgcttt tcgtttgagg gtacgctttt accaaaagaa agagatagca cagcgcccca 3425101 gccgcaactg aaatggccag ccgcatttct gcctgcatac tgaagtgttc ggtactgagg 3425161 cttacaccaa acgcgatgat gcccatcgcc gcagtaatca gaaatggctt cataatcgac 3425221 tggaaataag ctgaaaggtt aagcttgatg acatatgcca aaagccagcg cccaatcagg 3425281 aaattaacaa cgctgataat ggcatacacc catgcgactg tcagcaggct tcccgtctgt 3425341 acagctgcaa acagtgataa tccgtacagc agcagcacgc cggaatccca ataaaacgct 3425401 aagtcagctc ttcctttagc cagcaacaca gatccatttg gattcatgag cactcttagt 3425461 attccgacaa tcgcaagaac atttaggatc ggaacagcag caagccattt ttctccgaaa 3425521 accgctgtga taaaggcgtc tgacacagac acgagcccga ttaacagcgg aaacgaaaca 3425581 agcgccagca tttttgtcat attcagaaag ccttctctga tcacgctgtt ttcatatttg 3425641 ttttttgcga aaatagggaa tgccacccgt gtgacaatcg gattgatctt caaaaccgga 3425701 atggtgacaa tctgataagc gaggttataa atccccaatg cttcagcacc aataaaccgg 3425761 ccgatcaaaa tcatgtcgat atttgctccc agcctgttca caagacggga tgaaagctga 3425821 aaggctccaa aagaaaagaa atccttcatg cctctcaaat caaaaacaaa agcaggatgc 3425881 cacttttttc ggtatacagc ccaatataaa atccctttac tggactgcag caggacttga 3425941 gaaatcacgt acgccaaaat cgcatccatc ataaaaaccg ctatcgctaa atatccgaat 3426001 gacaatacat ttgaaaaaat ctctattttg cttaacgtat taaaatgcag ctgcttttgc 3426061 agcatatact gatattgctg tccaattggc gcgatcaaaa acataatcgc cagaatccga 3426121 accagaaaca ccagctcttc tctttgataa aatcccgcaa tgacaggact gctcacatat 3426181 aaaagaacaa acagcaaaac gcccgtcata atgttaagcc aatacaatgt tgacagctgg 3426241 cgctccgtcg cgtcgtctct ctgaattaat gctgcgccaa aacccatatc gagcacaatc 3426301 tgggcgaaaa ctgtaaccgt tgtgatcatg ccgacaagcc caaattctgt taaggtcatc 3426361 atatttccaa gcagggcaaa ctgaacaatt tgtatgattg taatacacat ggttgaaata 3426421 cttgtccact ttgcaccgct catgatttgt tttgtaatac ttggcatcat attccctact 3426481 tctttttaag ctcagattga tggtgaataa tggaatcccg ttttatcttg caccatcacc 3426541 cgtccaaact actttacaag tttttaacat aatttttaat tctaaagtga aagtcagatt 3426601 gcgaatgtaa tataaatcaa atatcagctt ttccttcggc gtcatatcgt aaccgccgtt 3426661 cacctgagcc cagacgctgt gtaaagcctg gaatctcatt ctggaatttt tccgtaaata 3426721 cgggccgttc cggacgaggg ccaatcatac tcatatcgcc tttcagcaca ttaaacagct 3426781 gaggaagctc gtcaattctc gttcttctga taaaagctcc gatccttgtc acccgcggat 3426841 cttgcttctg tgcccaaacc gccccagact tctcggcatc tattttcatg gaacgaagct 3426901 tataaagctt aaatggcttc ccgcctttcc ctacgcgttc ctgcgtataa atggcaggcc 3426961 ccggcgtctc caaacaaatc aaaattgaaa ataccgcaat cattggcagc gcaatcgcca 3427021 atccaatgag cgcaaaccaa atatccatta cgcgctttat tgccaaataa cgagccgtct 3427081 tttcagataa tgtaaaagaa tgtatttgtt gaactgagaa ttcacgactc acattcatgc 3427141 ttttctctgc actcactgac acacacctca cgatttgttt gggatgttat gatgacctat 3427201 gccagtcagt ttagcagacg gatgttaatt ggatgtaaat ggtatgttaa gaagtgtgaa 3427261 ttacgtgttt tttctgataa atgttgttaa tactctttta ctattttata tacaagtcct 3427321 atttgtttta atcatttcat ataaaaaaga gacaaatctg tgattagatt tgtctctttc 3427381 gattatctgt aataagatac tgtgccgtca tgaatagctt gtgcagcttt atctttataa 3427441 accgcttgct tcaatttact tgcatctgat gcattagtga taaaggcagt ttcaactaaa 3427501 acactcggca ttttagaata tttaataaca tagaaagcag ctgtttttac tccccggtct 3427561 ctcgttccaa gattagccgc taactttggt tgaatttgtt cagccagtct cttgctattt 3427621 gcagcttgat atgttgtatc gtagtacgtc tcacttccat ttggtgatga gctatcatta 3427681 gcatttgcat gtatactgag aaataaatct gcttgtgcag aagctgcttt atttactctc 3427741 tcctgtaaag aataaaaagt atcattagat cttgacagta ctggaagagc acctgaagca 3427801 tttagctttg tattgactct tttcgctata tcaaggttga cttctttctc aaggagtcca 3427861 ttgccgattg ctcctgaatc ttgatcaccg tgacccggat caataaagat tgtttcacct 3427921 acaactggat tctttagctg attagcaacc tttgtgctta cggcaggagt gtttccgata 3427981 atcataaagt ttgacatgtt tttacttcca ataattttac gggctcctgt agataaattt 3428041 tcaccatttg taagaataag agattgcttc ttcttagctg ccagtgtagc tcctgcaata 3428101 gagtcagggt agctgaatcc attgcttaca tatacggtgc ttgttgataa attaagtttt 3428161 tgtacgatat ttgcagcaag ctcatatctg tttgaaccgc taattcttgt aggagaaggt 3428221 aacttgttgt ataccgtatt gctgatactt ccagtgcctc ctacaacaac ggtactcgaa 3428281 attcccttat cttttatcac agacgtagtc gcactattta tagatgtttt atttgtaaaa 3428341 agaattggat acccgttttt cgctgcataa gggatgacgg ccggagcgtc tgcatataag 3428401 aagccgttca aaataacagc ttttgaagtc gcacccatcg cttttgccac ccgtgcagcc 3428461 gtatcataac ggttgcttcc tgcaattcgt ttaatactta tccccaagct tttaatctgg 3428521 ttagcagtgt tagaagaaac agcaggtgtt ccgcctacaa taattacatt tttagtctgc 3428581 atctctttca atcttgtttt cgtttcatat gaaagcttat cagaattagt gtaaagcaat 3428641 ggcgcattct tctggtaagc aagaggtgct gctgaaatag catctgcata ggaactccca 3428701 ccaacaatta cagctgtact tgctgttgaa tacatttgct ttgatatttg tacagcagtg 3428761 ccgtatctat tgcttccccc aactcttttc actgagttat cggccaaagc tgttggcaca 3428821 aaaagtatga gccccagaaa acacattgtt aggactttta tataagaacg caattgattt 3428881 cctccttaaa tggcgttata tcctaaaata atcaataact tgtcagagtt gtacctggat 3428941 agtaaaattt caaaattgaa ctatatgaat ctccagcttc tgctcttgct tttgctccat 3429001 attgactcat tccgatcccg tgaccatatc ctttaccgct gattgtgtac tttgaagtat 3429061 ctttttttac agtcacataa gtacttttaa atacagtcgc tccaatcatt gttcttaact 3429121 cacttgttgg tacactaatg gttgtaattt tgctcaagtt ataggagcca gtactgcttt 3429181 taacaaaata cttcactttc atcgatgctg tttttgcacg ctgcccttgt gtcgttccac 3429241 taaagcttaa atcgtcaata cttgcaattt tgacagaatc agcgcttgtt tctttatttt 3429301 tcaagatcca gttcttaact ccggaaagtc ttgcagaatc agtttcagtc gctgaagacc 3429361 accaagaaga aggcttcgtt aagtccaaag atttcgtatc tagctgttgt tttgacaaag 3429421 taagcgtcca gcctatttga ggatcctttg tatctttttt tgcaatcaag taaggtacac 3429481 ttgacgacca cacttcatta ctagcttctg tgtaaccacc attactggaa gaataagctg 3429541 cagttataag agatccatta tatttcagaa ctttcccctt cgtttgctct accgctttat 3429601 tggtattcga attccaactg tagccaccat aaacttgaaa agcggttgta tcaggtacag 3429661 tagttcctgt ttttgttatt gagtaggttc ttgcagcgac agtctgtgct ttaagagcct 3429721 caagtgacca gctagcaggc atttcattcg gaattactcc ttttaagtaa tcctcaaatg 3429781 gaatattctc atttaccggt cggatatatt tagtagactc aatagagaaa ttaaccgtgc 3429841 caagatactg ctttccatca agactaattc tgtttgaagt agaatagttt tctggtttaa 3429901 ttcttaggga gtttccgtaa gttttgatgt tttcaaggtt taattttccg ctgttgattt 3429961 ttagattata ggtgccaccg tcagctaaat aaaattcatc agcaagtgaa ttctcaactt 3430021 cagcagaaat tgaactggta cttccaataa agtcgtatgc atatgtggct ttatctttcg 3430081 ttatactttt agccgcagcc ggaacgctat cttgtttaac aaataaaatt tggctgtttt 3430141 tcttcgaggc aagcgaagcg cctatcaata cgtctgcata ttttgtcccg ttcgtcatta 3430201 cgactttatc agccttcaac tttagttgct taattatatt tgccgtaagt tcatatctgg 3430261 ttgatccagg aatcctttgc acagttgaag tttttttaat ttggttttct acactatcac 3430321 tgacgctaaa tgaactgcct ataatgatga cttgttttgg caaatcataa tccggaagct 3430381 tgtctttctc tgtaagcaaa atagggtatc cgtgtgctgc tgcatatgga gcaatggcta 3430441 aagcgtcttg aaatactctt ccggttacaa cgatcgcttt atcatagctg cccatttgct 3430501 ttgcaatatt ttctgataag acatatctat tttttccgct tatccttttc acagcgccat 3430561 atgatttcag cttgttttct acgtcttttg aaatgcttcg cgctccccca atgattaaaa 3430621 tattatcagg gttaaactta gcaatttgtc tttcagtagt ttttgttaac gtgtcaggct 3430681 gagtaaataa aactggtgcg ttcagttttt tcgccaatgg aataacaggc aatgcatcaa 3430741 taaaaatatc tcggttcacc aatatcactg tattaggatt tttccactgg ctgttggatg 3430801 caagagtcgc agtttcgtat cgtgaagcgc ctgcaaaacg atccgtaaca gcaacattat 3430861 ctccagttac tttataaaat cctgttggcg atagactgat gctagattta tttccaatat 3430921 aatttaacaa tttaactgag atgtttgagt ctgctgcaaa agaaactgat ggaatcaata 3430981 ataagattgc agcaagtgaa cacactatca attgtttgca agatttcaaa atttcaggtt 3431041 cctccctata tcttagttgg cacgttcaat atcttttaac agaagctgac cctcatcatt 3431101 tttttcatat gtaatcgtga ccttatctcc actgttaaac ttatcaagat cacttgtcga 3431161 ttcttcagtg atatcaagac taaccggctc attatctact gttacttcta ttgtatgagt 3431221 atcagctaac cctacataag taccttcttt tgtttcaatg ttactgtctg gcgatacatc 3431281 ttcaccttga ctcttttgac tattaacccc gcaacccgaa agaagcaata taaagaacag 3431341 taaagcaata aattttttca tttttttcac ctcattatat tttatcgtca acctatttta 3431401 tattttaaag aaaaattaag aaacaatgaa actttttttt ataaaaaacg actattttag 3431461 gatttcattc ttgtattaaa tagagttgta tttattggaa atttaactca taatgaaagt 3431521 aatttaacag acgaggtgca aaggatgaga aacgaacgca gaaaaaagaa aaaaacttta 3431581 ttactgacaa ttttaacgat aatcggactt cttgtactcg gaactggcgg ctatgcatac 3431641 tacttatggc ataaagcagc ttcaaccgtg gcaagtattc atgaaagcat tgataaatct 3431701 aaaaagaggg ataaagaggt cagtatcaat aaaaaagatc ctttttccgt cttaatcatg 3431761 ggtgtggatg aacgcgacgg cgataagggc cgtgccgata cgctcattta tatgaccgtt 3431821 aacccaaaaa cgaatacaac cgacatggtc agcattccgc gtgacacgta tacaaaaatt 3431881 atcggaaaag gcacaatgga taaaatcaac cattcatacg ctttcggcgg cacacagatg 3431941 acggtagaca ctgttgagaa cttcctcgat gttccggttg attattttgt gaaagtgaac 3432001 atggaaagct ttagagacgt tgttgataca cttggcggca ttacagttaa cagcacattc 3432061 gcgttcagtt atgacggtta ttcgttcggc aaaggagaaa tcacgctgaa cggaaaagaa 3432121 gcgctcgctt atacccggat gagaaaagaa gatccgagag gcgacttcgg acgccaggac 3432181 cgccagcgcc aagtcatcca aggtattatt aataaaggcg ctaatatttc ttccatcacg 3432241 aaattcggag atatgtttaa agttgttgaa aataatgtga aaacgaactt gaccttcgat 3432301 aacatgtggg atatccagtc cgattacaaa ggtgcgcgga aacatattaa acagcacgaa 3432361 ctaaaaggta caggcacgaa aatcaatgga atttactact accaagctga tgaaagcgcc 3432421 ctttccgata ttacaaaaga gctgaaggaa agcctcgaaa agtaaaacaa aaagaagctt 3432481 cgcacaatgt gcaaagcttc ttttttattt gcctgtaaat gaatccggtt gttcttttcg 3432541 atacccgtaa tgaaacagca attcttccac aatccggcgg gaagcctctc catctccata 3432601 cggattagaa gcctgggaca ttttcttgta ctcatcagga tcagttaaca gctgttttgc 3432661 aagctgataa atgttttcct catccgtacc tgcaagtttc agcgttcccg cttccactcc 3432721 ttcaggccgt tccgtcgtat cacgcagaac aagaaccggt ttcccgagag atggggcttc 3432781 ctcctgcacg ccgcccgaat cggtcaatat aaaatgcgat ttcgctgcaa agttatggaa 3432841 atcgatcacc tctaaaggtt caatcagatg cactctgtca gaatcaccaa aatgcttatg 3432901 agccgcttcc cggacaacag gattcaggtg cacagggtaa acgacttgta catcttcaaa 3432961 ttcccctaca attctgcgga tggccttaaa catgttttcc attggctcac ccaaattttc 3433021 ccggcggtga gcggtcaaga gaatcatttt atcctcaccc acctgatcga gaacaggatg 3433081 tgagtaacca tccctaaccg ttgtgttgag tgcgtcaatc gctgtattgc ccgttacaaa 3433141 aatagagtcg gcctttttgt tttcttttaa taaattgtct ttcgcctggc ctgtcggagc 3433201 aaaatgcaaa tcagcaatcg cccctgtcat ctgtcgattg agctcttccg gaaacgggga 3433261 atacttattc cctgtacgga gccccgcctc cacatgaccg acagcaattt gatggtaaaa 3433321 agcggctagg cttccggcaa acgtcgtcgt cgtatcacca tggacaagca caatatcggg 3433381 tttgatatct ttaaacaact catccaatct tacaagtgcg ttagacgtaa tctctgccag 3433441 tgtctgccgc tccttcataa tgttcaaatc gaagtcaggc ttgatgtgaa acgcatctaa 3433501 cacctgatcg agcatctgtc tgtgctgtgc agttaccgtt acataggaat ctatttcagg 3433561 atattttttc aattcaagca caagcggtgc catcttgatc gcttcaggcc tggtcccgaa 3433621 aacggtcatc acttttagtt ttttcatatt tgtcacctgg ttttctgcta tagtaaataa 3433681 attcatacta catattctac atgaaaatgc atcattttaa atcatttcat tcttgattca 3433741 aataaaatga tataagtttt aatattaagg ataaagcttg tttaaaaatg gtttatccga 3433801 tatcataaaa atgtgtaaaa acatattgaa aagggtaaat agagaatagt ttaaccataa 3433861 attttttcga tcataaggaa ggtgcctttt aaatgaaaaa agtacgtaaa gccataattc 3433921 cagcagcagg cttaggaaca cgttttcttc cggctacgaa agcaatgccg aaagaaatgc 3433981 ttcctatcgt tgataaacct accattcaat acataattga agaagctgtt gaagccggta 3434041 ttgaagatat tattatcgta acaggaaaaa gcaagcgtgc gattgaggat cattttgatt 3434101 actctcctga gcttgaaaga aacctagaag aaaaaggaaa aactgagctg cttgaaaaag 3434161 tgaaaaaggc ttctaacctg gctgacattc actatatccg ccaaaaagaa cctaaaggtc 3434221 tcggacatgc tgtctggtgc gcacgcaact ttatcggcga tgagccgttt gcggtactgc 3434281 ttggtgacga tattgttcag gctgaaactc cagggttgcg ccaattaatg gatgaatatg 3434341 aaaaaacact ttcttctatt atcggtgttc agcaggtgcc cgaagaagaa acacaccgct 3434401 acggcattat tgacccgctg acaagtgaag gccgccgtta tcaggtgaaa aacttcgttg 3434461 aaaaaccgcc taaaggcaca gcaccttcta atcttgccat cttaggccgt tacgtattca 3434521 cgcctgagat cttcatgtat ttagaagagc agcaggttgg cgccggcgga gaaattcagc 3434581 tcacagacgc cattcaaaag ctgaatgaaa ttcaaagagt gtttgcttac gattttgaag 3434641 gcaagcgtta tgatgttggt gaaaagctcg gctttatcac aacaactctt gaatttgcga 3434701 tgcaggataa agagcttcgc gatcagctcg ttccatttat ggaaggttta ctaaacaaag 3434761 aagaaatcta aacaaaaagg ctattggaca ttcatccaat agcctttttt tatttcaaca 3434821 tcaaagtcaa tgtatgctct tcattatcaa ctgcgaagac ctgatcaacg gcctgccgca 3434881 aaaattaata atcccagaca aacacactga ttgtagagtt aaacaaacta aatgaaaaca 3434941 taaatacaaa catgcagatt aaatagtaaa tatcttgtat tcaatgcaag ctaagtaaac 3435001 accacttgct aaaagaacaa tgactaaaca accagcatta caaaataatt aaataaattt 3435061 gaagcaatta caacagaagg cagtgaactg tcggaaagtt cattttggct accatattaa 3435121 tccctttaac tacgctgttg gatttatcaa gaattgtcgg gctaatagaa aaccacggaa 3435181 tcaaaccagc cagcattcaa acgataaaag gcacttctcc gatacctgtt atgaccagct 3435241 tactgttgcg catcccaaat acaaaccagt acgccatcat tagaataagg ggatttaaaa 3435301 cctgccataa tacaccaaaa taattgattt tttggatctt tcggttaaag aaatttaaaa 3435361 gtaccagtga atattgtaac aaatgttgag tttttttcac ttttaaaaag taaagagaag 3435421 tctcgcagaa cttctcccaa catttgaagt gtcaatataa aacaaaccaa cctcatttag 3435481 caactttatt attatctaat tccaaaatag cattataaat acgattccta ttatttttat 3435541 cagtatatgc aaaaaagtta tctactcttt ttctatactt atcttccata cgactattgt 3435601 ttttcatata atagataact ttatccacta agctattatg attttctaat acatcaccaa 3435661 accccatttt tttataatca taataatcaa gtttaaaatg gtatgacttt tcgtattgat 3435721 aataaataac aggttttttc tcatatgcaa aatcaaacgc aacagatgaa aaatcagtaa 3435781 tcattatatt agaagaatta aatagcattt gatagctgct gttatagtcg gcaaactcca 3435841 cataatcatg cttttcaaag tctacaatct gttgctgaat atctgggtga ggaaaaaaag 3435901 ttattttata attatttttc ttagcaaatt cgattagccg ttcatcatta atcaaagcat 3435961 tatacctaga aaaatattca ctatctttaa atttcgggtt gtacggtctt actccttttg 3436021 cctgatcttt cggtaataca atatcttttc tccaagtcgg cattattaga agttgctttt 3436081 ctccctcact cttcttaaga ttatcgtatc tcggaaatcc acccaacaaa atattctctt 3436141 ttttatagtt gtaattccct ttcacaatag accgatattc aggtttggca gaagtgacta 3436201 ataatttgat attcttgttg tatttgttta accattcaga atgatctgcc attgttattc 3436261 cgtgctgtaa aaagataaac tcaaagttaa ataaatctct aaaataaatc tccatattaa 3436321 aaaatggatt tacaacccat atatctgcat gtgtcgatat tactttggaa gaggataagg 3436381 ttaaaatttt atgtctaaaa gatctgtatg gtatgacctt tccatatttt ttgattctgt 3436441 cgtaatcctt gctatctttt tttattataa agtatttttt taccccatca ttcttgttga 3436501 ttgcatattt aaagaggtgc tcggcattat catcagcttt gtcttgtctg tctatgaata 3436561 accatactgg ttttctatta aaaatagtga aaacatggtg taccattctt gccatcagtg 3436621 ccttcttaat cgctgatttt cgtttttttg atttttcccc tgatttatgt agggatttta 3436681 agaaacgaaa ctcttttata aatctatttt taaaattgtt ttttttgaac attaattttt 3436741 tataattata ataaaaaata taatcttttt tagccacata agtattatat aaatcgtttg 3436801 acaaacctga atacttgaaa aaacgaagtt ttgtcaactt ccttttttta cccttagtta 3436861 taaaaaactc aatatgatga ttatctgcta gatgaccttt gggaatatct attgaaaaac 3436921 cgggatattt ttttattact tctcctaaac ttatataatc attatgctgt ctttttatat 3436981 tctttgcttt tatttttgtt tcgccaattt tagcataaaa cttaaaacct ttagaattaa 3437041 acagcgagct ccaaaagcct tctatgtgaa tggaatcctc attttcttct aaaatttcaa 3437101 tagttaaagt ttgatccgat aatttcgaaa caattttacc ttctctgtat aaataataat 3437161 cctgttcagt ttctctttca tatacatacc tactataatt ttcaccgtgc tttattttta 3437221 aagcatgata taaatagaaa tggctgacac tttttgtttc aatgatgaca tcgtcgtcaa 3437281 tatacgacaa tacttctcga atcaatgtta aaaattcact gtattcattt tcgtctaaag 3437341 gtgtttcact gatatcctta atcaataatt tccacttcaa atcatgcata accatatatt 3437401 gaagaaataa aggtattttc tgttcatgat tttttataat atcgattaaa ttctttgaga 3437461 aagtgataag tgaatggtta aaccaattct tatttgcttt agcagtctgc atggcagatg 3437521 atccatcttc tctaactcta taatggtatt ttgcctcttt aaccagacca tactttttct 3437581 tttgcgatat gattaaatta actagtttgg catcttcacc tattttacaa ttttcatcaa 3437641 acctgatatt tttcaaggca tcttttttta taaatgtaga acaacaatga gttaatatat 3437701 gatgcggttc tttttctaca tccaaaattc ttgtagaaga aaacttatta tttagattat 3437761 gttctccagt tcttccttct gcaaaaaaaa tagggattgc tacaatatca atttcattct 3437821 tatgttcgtc aaagaagttt aaaacatttt cgaatgttcc ttctgaaact aaatcatccg 3437881 gatccaaaaa ttgaatatat ctaccttcag catactttaa accataattt cgagcactgc 3437941 tcactccgcc attctgtttc tttgcataga caatgttatt gggatatttc tgagcatatt 3438001 ctttacaaat gatttcactt ttatcggggc tatcatcatt caccagtatt aactgaatat 3438061 tctcaaaacc aatagtttgg ttaatgatac tttctatagc ttcagtgaga tacaactcaa 3438121 cattataaat cggcattata acactgaaat catagttaaa acttttttcg ttcataaaag 3438181 attactccta acataatgtt tatatgaata agaattcggg taaataaaat taagaaacaa 3438241 gagagtacta atttttgcaa aacaatttta atttagtaaa atgtatgaaa agcattcctt 3438301 accttttttt aaaaaccctt gtaagcaaac ttttaaaaat gttcacatgg ttaagttcta 3438361 aagaatcatt tggtgttttt agtacaaagt caaatgcaaa ggcccaaatc ggtatttcga 3438421 caacaaaacc agcatatcta aaatctctta atttatatcc ccatacttca attgtttttt 3438481 tcagttcttt tcgtttgcat ttttttaatc ttttaaaata ttttatatat attctgtcat 3438541 tttctttcat ctcataatac tggttaataa agtgccctgt taattcaagt ctaagccctt 3438601 ttatttttgc cgaagtaaca gtacatgaac tatgcagtac tctttctttt tttatatttt 3438661 caagagcttc tgtattttct tttaataagt gaaacataaa ttctttatag tacatcggca 3438721 tatcttgttc ttttataaat tgcgggtcaa taaattttaa aactttaata aaatcatcaa 3438781 caaaaactct ttgttcttgt tgatctaaaa cagacttata aacatctcta tagttcggat 3438841 ataaaaacag ttttatatga tatacaatta aaaattgcaa ataaggcaaa actatatcat 3438901 atttgttgaa tgaatccatc aacaaagtca tgtaacattc attcaacaaa tatgtgtacc 3438961 tttttttgtt aaaccatgaa cgatcaacta aagaatcctg ttctttccgt tttctataaa 3439021 aatactttcc ttctgcaact gctccgtatc ttttttcttt cagtaataac tggttaaaaa 3439081 agatagcgtc ttcccaaaac tttatagatt catcaaaaag gacggtacta gttagtgtat 3439141 gtcttctgta aaaagtgccg ccaatataaa aatgaatagc tttataatcg ttgagaatat 3439201 ttataactct tgttcctttt tcaaatctat tatttaattt atgtccccct tctttttcac 3439261 ctgtgtaata aacaggtaat accgcaatat ttacatgttc ggaatcacaa aaaaaatcat 3439321 aaacactttg cagcgcattt tgagagaatg catcgtcaga atcaagaaaa ccaataaatt 3439381 tagatctttc gcttacattt gataatccac aatttcttgc agcagaaggt ccagagtttt 3439441 caattttcat gattttaata ttattaggat atagattttt aaaggattca caaatttgag 3439501 gactgctgtc aacactacca tcatctatta atatcagttc tatattttcc ttaaatccaa 3439561 ttgactggtt aaggacactc tctattgaat atcttaaata attttcagaa ttatatattg 3439621 gtataattat agaaaacatg tttgtacctc tttatttaga agttaaagga tcgtttcaat 3439681 tactctttta gaagccttgc ctcttctaaa ttacaaaatt tattataaaa atcctcatag 3439741 ttatgatcta tataaggatt atgtaacaac tcttttaccg tatctataag ttcttcactt 3439801 gtttgaagca agtttcctgg cgttttttgc tgaaaattaa agtaaaaacc tctgatacag 3439861 tctctataag ccgggagatc atacacaaaa aatacaaggt ttttttaaaa attcatatta 3439921 tcaaaaaaga cagaagaata atccataatc aataaatcac taattaaata taaatctcga 3439981 atatctttat ttaaagaaac atcgttcaca aaatatttat atttccctaa ttaaattgtt 3440041 ctgaaactgg ataataccat tcttacaaga ataaccatag agtctccaag gttccctctt 3440101 catttcctct aatcaaatta aagttaaatt tatactggcc agctttctta aaattcatta 3440161 tcccgcaaag ttggtgcata taaaattatt tttctttaat tccttatttg ataatgtaga 3440221 attggtaggg gattgtagct aaactgtttc cagaatagct ttcaaataaa attaatttat 3440281 tgtttcttgg cagaaggaca aaaattttaa acaaaactga ataaactcta actagtaaac 3440341 ttctgcaatt ggttataata aaaatttcat cagtgaactc cttaaagagt gaagattaat 3440401 atttacgcaa acaagaaaaa aagaagcaac tgaatttact tcaagcctct tttagttagt 3440461 gcttctataa actagccata tcttttctga tttgggtagt tgaaatgcct gctattcttg 3440521 taaggtaaat ggcctcatag tattcctttg tagacaatcg tacgattaag taatcccagg 3440581 ttcttttgct ctttccagta gcttcatatg tccatagtga aataaatcaa acattccgta 3440641 cgtatcactt tcttcattag ataacatcac cttccaacct tttccaactt agaaaaaaca 3440701 aaaatcctta actgattgtt tatcatttcg acatattttt tacgttccat taataataaa 3440761 caataatagc atatgttcct ataaaagtta aggctcttta aaaatgtaaa tcatcagcac 3440821 tttttgacaa tatcgttgca ttgatgtgta ttttttacag atctgatatc ttatctatac 3440881 tcattacaac aagttttcta ttccggaaga gtcaattctt tttgtcgcgt tttcaagtgt 3440941 aatgattttc tttctgctgc gtcatttatt ttgtacgccc tcctcatatt acttcatcgt 3441001 caaaacgtga aggaattgta atacgtagtt cctaaaaatt ttcgtggtaa aatttagtga 3441061 agtctttatc aggctaaggg actttatcta aactacgaat tacatatgga gatatataga 3441121 tgaaaaggag ggttgatatg atataaacga aaatcaatta gataaaggaa aaactgaaca 3441181 cttctgaaaa aagtgataag tttctttcac tatatcctcc aaaaagaacc taaaggtctt 3441241 ggacatgctg tctggttcgc gcctaacttt atcggcgatg agccgtttgc gtttctgctt 3441301 ggagacgata ttgttcaggc tgacacacca gggttgcgcc aattaacgga tgaatatgaa 3441361 agaacacttt cttctattat cggtgttcag caagtgcctg aagatgaaac acactgttat 3441421 ggcatcatcg ccccgctgac aagtgaaggc cgccgttatc aggtgaaaaa cttcattgaa 3441481 aaaccgccta aagacacagc accttctaat cttgccatct taggccgtta cgtattcacg 3441541 cctgagattt tcatgtattt agaggagcag caggttggcg ccggcggaga aattcagctt 3441601 acagacgcca ttcaaaaact gaatgaaatt caaagagtgt ttgcttacga ttttgaaggc 3441661 aagcgttatg atgttggtga aaagctcggc ttcatcacaa caactcttga atttgcgatg 3441721 caggataaag agcttcgcga tcagctcgtt ccatttatgg aaggtttact aaacaaagaa 3441781 gaaatctaaa caaaaaggct attggacatt catccaatag ccttttttta tttcaacatc 3441841 aaagtcagtg tatgctcttc attatcaact gcaaaaacct gatcatctgt attcacaaga 3441901 aaacgcttct tgctgctgtc atacaataca tcgctatcac ttaaggatag tgacgccggg 3441961 ttgataggag aaatgttatg aaaaataagc tctgttgctt tatcattctc cagtacataa 3442021 ctgatttttt cataatcaaa attcagcgtt tttctgccgt cagccttatt tccttcagta 3442081 taaccattca atttcgattg aatgctggtg ctgctgtctc ctaggaattt cagaaagtat 3442141 tcataggaag atgctgcgtt ttgcgagaca taagacgtaa atgcagtggc atgcaattca 3442201 gcgtgtttca tgttagttgc aacagcgctc tgtttcacat aataagagtg cccgtcaaac 3442261 tttattttcg ctgcttgttt gccttttgca gctaccgtta cttttgtacc gaatggcagt 3442321 gtaacgtcag ccttctgttt caaaccctga tccttataag cagccgcttt ttcatttgct 3442381 ataaaccctt gcttattgat tgcagttaag cgttcctctg acttgccctt tgcatcgcca 3442441 tgatggttct tcacttcatt ttgcggaata gcgccaaacg aagcaattgt acgaagcggg 3442501 gcattaaaga acatcgttcc cgccatgaag acagtcagaa tagacaaaat agcaatttga 3442561 atggcattgg ccagtgattt cggctttttc ttctttttgc ggaaacgggc aaacgcttca 3442621 ggatcttctt tcttcctctc ttctgtctgc tcttttttat atgtctcttt ttcttttttc 3442681 gatagcttat taaaccagtc aataaacgct ttgtactctt tcacaaccgt ttttgtttca 3442741 tcaaacatac gaagctcgcc atagtgcatc caagcaacac ggtcacacat cttttcaatc 3442801 tgaccgattg agtggctgac aaagaaaatc gtttttcctt gctttttaaa ctcatttatt 3442861 ctgtctacac acttctgata aaacgtttgg tcccccacag aaagagcttc gtcaataatt 3442921 aaaatgtcag gatcaatatg cacggagatc gcgaaaccga gacgcgactt catcccgctg 3442981 gaatagtttt taaccggctg attaataaaa tcgccaatct cggcaaattc aacgatgctg 3443041 tcatacatat catcaatttc tttattggtt aaccccatca tcaaacactt gagccggaca 3443101 ttgtcccggc ccgttaattg gttattcaaa ccggcagcaa tcgcaatcag cgacggctgg 3443161 ccgttcattt caatttcacc gctggtcggc ggaataattt tagccagcag gttagacatg 3443221 gtcgattttc ctgacccgtt tattcctaca aagccgattg tctccccttc atacacgtca 3443281 aaggagacat tccgcacagc aaaaaaacca ttatccttag ccggaaaaaa caatccttta 3443341 atcttgtccg attgtttttt atacaaatga tactgctttg aaacatttcg aaacgaaact 3443401 tttagtttca tcgtaaaatc tccttacgta ttaaagaaag tcaacaaact tgtctctgaa 3443461 tttcatatgc aggatagaac ctactaacaa taaaaggaat gtgaacaacc aaaagtacag 3443521 cgtgtacttc atgtcatgga aaaaccatgc tccatctaag aagctgttcc ggaatccttc 3443581 aataatatag aatagtggat tcaacttcag aacaggcact aattcggggt ggctttgacc 3443641 gagtttcgca ttaacatccc aaaaaattgg caacaagaaa aacaaaagtc ttgttacggc 3443701 ctgcagcaaa aattgataat ctctaatcag cacactgatc gttgagttaa acaaactaaa 3443761 cgaaaacata aaagcaatca tacagatgaa gtaataaata tattgtaacc aatgcacact 3443821 cgggaacaca ccattaacta ggagtacaat gatataaatc accatcatga tcatataact 3443881 aaataagtta gatgcaattg ccacggacgg tagagaacta atcgggaagt tcattttagc 3443941 caccatatta atgcgcttaa atacactatt tgatccatca agtatagttg gactgatgaa 3444001 aaaccatggg attaatcctg ccagcatcca aataataaaa ggcacttcgc ccgctccggt 3444061 tgtcacagga ccgccctttc taatccccat accaaatacg aaccagtagg ccagcatttg 3444121 gataagcgga tttaagaact gccataagac acctaaataa ttcatttgat atttagactt 3444181 ggtttcataa gccgccaatc ttaaaattaa aggaaatgac gttatttgct ctctgagtat 3444241 acgcaacaaa tcattcattt tttatcttcc ttagacttaa ttgtttttgg gaatctttct 3444301 gtttaaaatt tgaaagcacc gctgattatt gtaacagatc ctgcattttt tttcacttct 3444361 caacaagtat ctaaaaagct gccgaaaaat cgacagctat acattttata aaataaccta 3444421 aattattcag ctttaaatac agtattaaca accttttcag atgaacgtcc tgactctaaa 3444481 tagcaaaact tatcatagaa aggaccaaaa gaaaccggaa gcttataatc aggcgatgag 3444541 atctgcttga tagcctcaat cgtttcttca gtagttttta ccaaaggacc aggagcttct 3444601 ttttcaaaat caaagtagaa accacgcaac ttgtcccggt aggtttcgat gtcagggaca 3444661 aagaatagca ttggccgttt taaatttgca aaatcaaaga atactgaaga ataatcagta 3444721 atcagcaaat cagaaaccat atacaattct cgaatatcct cataagcaga aaaatcatat 3444781 gcaaatcctt caaaaggacc taaatcaaaa ttctcagcta ccagataatg cattcttaag 3444841 attacaatat attcatttcc aagttcttgt ctaagttgat gcaaatctaa atcgagatcg 3444901 aacttataac gcccttttgc atagaactga tcatctctcc atgtaggggc atataaaata 3444961 acctttttat cacgaggaat atttaaccta ctctttatca atgatattgt ttcctcatta 3445021 ttatcattat gaagaaaatc atttctagga tatccagatt caatcattgt cttgttaaac 3445081 tgaaacgccc gtgtaaagat ctcagttgaa taaccatttg gggaaatcaa gtaatcccaa 3445141 ttagaagctt ccttgataaa attcctttta tattttttgg tgtttgtacc aggcatatgg 3445201 acttcttcca tatccattgc aagtcttttt aaaggtgtgc catgccatgt ttgtaaatat 3445261 gttgtatgac taggtttcgg aatccataat ggaagccggc tgttaacaac ccaatactca 3445321 gctcttgcca tagcgaagag ccattttaat gagaggcgat taatgtaagg aattcccttt 3445381 tcatcaaaag gcgctgaata ttgtttattt acactccaat acattttata ctcagggtgg 3445441 ttttcccgca tatattcgta aatcgctctc ggattacaac tgtattgttt cccattaaaa 3445501 ctttcaaaaa tgactgtttt ccttttaact ggcattctgc tagccatcat gaatagagat 3445561 ttgtatgttt tagtgattaa cttgtttctc atttttgtga tcttttttat ttttgatact 3445621 aatctcttct tctttccttt aataaagtat ttcatccttg ttttcaggct atagtcgttt 3445681 actctgatac ctagagtctg ctttttcttt ttcttaaaga cttcataacg aactggtgcg 3445741 ttgtttgttt taataatact tactaatcct tttaatttgt tttttcgatc tcctaaaaca 3445801 agagcagtgc tgttgaactg aatatccgtt ccttcatcgt cattgcatat atactccata 3445861 aaaagacgat aaacataacg tttttcattt gagaaaggaa tttctttcaa aggcactttc 3445921 acttcaaaat catacagttc cggaacaaaa ccatctgctc tcatgttttc caggccatgt 3445981 gtttttcttt ctagcttgat tggaaatttt tcctcaatag gtgtttctcc accctttttt 3446041 aaaataaggt tcaagttttt tatccgatat tgattttcgg aactcaggta ccccgcataa 3446101 cctgttatgc ttatttcttc agagctaatc tcgatttgat caaatctgat gattttggcc 3446161 tctcttttca ccttaataga aaagttgcct ttatcagttg tataaggtaa aatcaaaagt 3446221 tctgtggttt gatcgacatg aaaggcgcgc tcaattgaat ttacttcagc agaaagacgc 3446281 ttcaagagtg gttcctgctc cgcatcttca tatttttttc gaaattcgac ataaaaatca 3446341 tatgtttgtc ccatttcaac aggcataggc aaaacatgag catttatctc agttttatac 3446401 tctaatgagc cagtgttttg aagcggaaat tcagattccg ttcctgaacg tctctctttc 3446461 agctttaaaa ataactggta atcctctaaa aattggtgtt ctgaatcaat tgagattaac 3446521 aattcaagac ttcctaaatt gtttttcaag cttttcaaaa tacatttaat cacagtgttt 3446581 tcaatcatta cttttttctg ctcctctgta taaaagctct ttcctttttg cttcctttta 3446641 ttagtgtcaa ctactaagga cattaactct cttttatttc cgtgaccctc caagagaaat 3446701 tgcctttaac tgttgtatag ggctctactc tatagccatt attagtatct atactgtttc 3446761 ctgacaattt tgtttcttca ctcgaaagtc ttcgcattgt tttaatatgg ccatttgcat 3446821 tgaaaacaat ataaaaatca ataacttggg ttttattagc agctatcttt tcaatattta 3446881 catctttttc gagatcaatt acaaacagtt gatcattttg taagtttgtt gaaataattt 3446941 cagccttatt ctttctgtcc aagcccacta aacgtatttt tttaatatca ttatgatcaa 3447001 aattctcaat gtcaatttct attttagttt tatcaaaatc ctcagtatag gaactaatag 3447061 aaggatcttt ttttccaacc tttttagaga acttctctct ttctattcgc acctcaatca 3447121 tctgattaag agcaaaagcc caattttcaa tatagttggg tcttgaatat ttttcagcca 3447181 ttttaaaagc ttgttctgaa aatttttgat gagtactttc atctttcatc aaagagataa 3447241 tagcttgacc caatttctct atattatact gttcaatgac atatccattt gctccgtcag 3447301 taactaagct ccttgctccg taatcataat cgtatgttac aactggacat ccattgctca 3447361 gtgcctccat atttgataga ccgaaccctt caaaatgaga ggttgaaatg gttagccaag 3447421 ctttttgaaa ctctgagtca gggttatccg tatagccttt caaaaagaca ttgttctgca 3447481 gtttggtatc ttcaatttct ttttttattt tttcgaaatc ttcacccgat ccgaatatat 3447541 caagttttgc ttcaggaatt tctttcacga ctaaactaaa tgcttttact gcatgtatca 3447601 gatttttcat agatgcaagt cttgaaataa tgacagcttt gtatttttca ctcggcacat 3447661 tcaatacagc gggatcaaga ggcttatcaa ttgtatgcgg agtaaagaaa aacgtctctt 3447721 gttcccctga aatcaattta aaatcttcta gctgctcctc agttataaaa aagacagcat 3447781 ccaaattata catctgacta aatacttctt tatagcgacc cttaatttga tatttattgc 3447841 tgccgtaatg cttgttatga ataattgctc cataatagga agaaggtgat tttttcactt 3447901 taaagacatg tttgtcttgc ggtctgctgt ccactaaaaa caacttaggt ttatcatttt 3447961 gtttttgcag atattctatc caatattgac gcagttccga ttcatctttt acttttatct 3448021 caccctcaag ggagtaccaa ataatatgag ataattgaac atctttttct tcattgttcc 3448081 atacatagag tttgtctaaa tatacttgat tttggtcatt aatatattcc tgcagataca 3448141 tcttgtttag ctgcacatca taatgagtaa cgagaactaa gtttccgttc ttcgtatatt 3448201 cctctctctt tatgagctgg tttttatcat tccaatagtc gacgtaccgg atagtttctc 3448261 catctccgta gtaaactaca gacatttcat tgttcttctt accaaacaat ctcaacagag 3448321 tttttgcaaa tttccccatt ccaacttgct tttttatctg gtcaaggcct atcctttctt 3448381 cgtatgatct tttcccattt gttctaacac ttaaaaaatc atcgaataga ttaataacac 3448441 ttgtgaattt tttatcaatc ttaccgttgc tgtacaattc atcaattttt gaagacaact 3448501 ctaaatcaaa acgaaacgtt aagaaaaagg tgttttggtt acactcttct ccaaataatt 3448561 ttgaacgcaa taataatgat ttcgtcagac cgccataatt acttggcagt ccaccagaga 3448621 taaaataata atccatgtca ggaatttgtt ttatattaga ttcactcacc gcatgtaaag 3448681 acaatttttt actccctttc ggcatctaga atatatgatc attgaaattt atatctaccc 3448741 ggatacttta gtcacaaaaa tcaatgtaag catcaaaaag tacttcttat ttcaataaga 3448801 agtactttaa ttagatattg aaccaatgat atcaggatcc taaattataa accagcaatt 3448861 tcctctttga tctttgttgt agagatgcct tctgttcttg ggaggtaaac aacctcacac 3448921 tgatctttga gaaagtcaaa tttaccttcc cagtcatccc ccataacaaa aacatcaata 3448981 ttatgatcaa taatatcttg ctttttttgc tcccaattct tttcaggaat tacttcgtcc 3449041 acatatcgaa tggtttctaa aattaattta cggtgctcat agctgtgata agcttttttt 3449101 tgcttttgta aattgaattc atccgttgaa atagcaacaa ctaaataatc accaagctgc 3449161 tttgcacgct caagcaattt aatgtgaccc caatgcagta aatcaaaagt tccatatgtg 3449221 ataacttttt tcatttaaag aaacgctcct tcctaatgtt aaacactatt aaaaacacta 3449281 ctgacgttag cgattaaatt ctaaaaacct gtttgtattc cttatatcga catatttctc 3449341 gtatgtcttc actgatcatt aattatagca taccgcctaa aaaaggttaa gtactcatga 3449401 ggagaaaaac attccaaaat atgtaattac actcagactc cattggcacc aaggtctgtt 3449461 gttcattcgt tcattcaatt gtaaaattgg aaacatattt aaatttaatg taaagataat 3449521 gttaatcctt tgttgaagat ttatgttaaa atataaggta gcttgatttt gcttttagaa 3449581 actctcggtt tttaactata taaatagaat cttaaaggaa ggaggagcca gacatgcaaa 3449641 cagagactat tcacaatatt ccttatgtta acagtaactt aacatcattt atcgattacc 3449701 tagagaaaca ttatattgat caaaagattg gtgctgtcat ttccacagtc aaccctgaaa 3449761 ttgcatttgc agctattaaa gatcgggact actttgatgt actatcttct tcaaacttca 3449821 ttttgcctga tgggatcggt gtagtcatga tgtcacgttt gactaacaac aggcttcagt 3449881 cccgaatcgc aggttacgat gtttttaaag aacttctggg cgttgctaac aaaaagaaaa 3449941 aacgcatatt tctgtacggt gcgaagaaag atgttataaa aggtgttgta tccaaaattt 3450001 cttctgaata cccaaacatt aaaatcgcag gttattcaga cggttatgtt caagatcgca 3450061 ccctagtggc aaaacaaatt gcaagagcaa atcctgacat ggtattcgta gctttagggt 3450121 atcctcatca agagaaattc attcataact acagacactt gttccctaaa gccgtatcta 3450181 taggtctagg aggaagcttt gatgtattta gcggtaatgt caaacgggcc ccttcctgga 3450241 tgatacgttt aaatttagaa tggttctacc ggttaatctt gaatccatgg cgatggaaaa 3450301 gaatgcttag catcccaaaa tatgctttaa cggttttaaa agaagaaaaa aacaaaaaaa 3450361 ctttctatcc aaagcctgaa aaagatcata caaaacagat ttaaaaacaa aactttcaaa 3450421 taaatggatg ataaaaatga aaataagatc actactggcg aattgctatt tgtatttttt 3450481 atcagcaatc gccttttttc tgcaatgggt gaaacctgaa agcaaagtga ccctcctgat 3450541 ctcattcgaa gcaaacgcaa aagcgattct tgaggaatat gaacaaggac aatactctta 3450601 taaacttaac atcctgtata cccagcaggc ctctgctatt gccgagagct tcccgaatgt 3450661 agatgcatat ttattacaag aaaaaaaccc tatccatctc attaaagctg tatacctaat 3450721 gtttaacagt aaagtgatca taacagataa ttactttcta ttaacaagtg tgttaaataa 3450781 gcggaagcaa acgaaatgta tccaagtatg gcacgcaaat ggctcactca aaaaatttgg 3450841 tttggaagac attacaaaca tgcaacggac gaaaactgat attaaaaggt tccaaaaagt 3450901 atacagttcg tatgattatt taactgttgg ctcagaagag atggcaaata tcttcaagaa 3450961 atcatttgga ataaaggata accaattatt aaaaataggt gtacctttaa cagaccctta 3451021 ttaccgagaa aacaagaaaa aaatttcaga tactctaaac atacaaagaa aaaaaataat 3451081 cctctatgca ccgacgttta gagattataa tatgcaatca attcaattgc cttttacaga 3451141 agaacaatta attcatcagt taaaagaaga atatgtttta tttgttaagc tgcatcccgc 3451201 cattcagaac aatattgata ttaaatattc cagtgattat attaaagatg tttctaacta 3451261 tgccttgttt gatctactca tggctgcaga catattaatc actgactatt cttctgttcc 3451321 ctttgaattt tcgattttaa ataaacccat tcttttttat acttacgatt taaaacttta 3451381 tcaacagaag cggggattgg ttgataatta tctttccata atacctggaa gagcctgcta 3451441 tgacagtgaa tcattaataa atgaaattca aaccccattt aattattcca aaataaaagt 3451501 tttttccgat agatggaata agtattctga tgggaattca agccaaaatt tattgaattt 3451561 catcgaaaat ttaataagct aaatgatgac acttgttcaa aacagaacaa gtgttctttt 3451621 ttctattgaa taccgaacgt atgtttgctt taatgtaatt agttgcttat ggcagcaaat 3451681 aataatagag gtggtaaatt tatgagaaaa aaagaactgt ttgatttcac caacatcacg 3451741 ccaaaattat ttactgaact acgtgtagca gacaaaaccg tacttcaatc attcaatttc 3451801 gatgagaaaa accaccaaat ttatacaacc caagtcgcaa gtggattagg aaaagacaac 3451861 acccaaagct atcgcataac tcgtctatct cttgaaggtt tacaattaga cagcatgctg 3451921 ttgaaacatg gaggtcatgg tacaaatatt ggaattgaaa accgtaatgg caccatttat 3451981 atttggtctc tatacgataa accaaacgaa acagataaaa gtgaattagt ttgtttccca 3452041 tataaagcag gcgcgacttt agatgaaaat tctaaagaac ttcagcgatt ctcgaatatg 3452101 cctttcgatc atagggttac acctgctctt gatatgaaga atagacagtt ggcaattaga 3452161 caatacgata caaaaaataa taataataaa cagtgggtga caatctttaa cctggacgat 3452221 gcaatagcaa ataaaaacaa tcctctttat actattaaca ttcctgacga acttcattat 3452281 ttacaaggtt tctttttaga tgacggttat ttatattggt atacaggaga tacaaacagc 3452341 aaaagctatc cgaatctcat aactgtattt gattccgata ataaaatagt gctgcaaaaa 3452401 gaaattactg ttggcaaaga cttgtccacc agatatgaga ataacttccg tgaaccggaa 3452461 gggatctgta tgtacaccaa tcctgaaact ggggcaaaat cattaatggt gggaattaca 3452521 agtggaaaag aaggaaatcg tataagcaga atttatgcat accattctta tgaaaacttc 3452581 atgaatcatg tacctatgct tcgatcccct ttattaaaaa ccgtggggca ccaagataca 3452641 cctccagaaa gatttcaacc atttattcaa accttcattt tagagtataa tgctcaaaac 3452701 aaaaaatgga tggttccgac ttcaggttat ttaccatctt acacatcaaa tttagtccga 3452761 aatattacta tcaatgcaga tggaaacttg caagtcacat taaatgaacg ctatattagt 3452821 ttactgcatc aatcgataga aggagatttc cgcttaaaac aaaaggatat ccgaatggga 3452881 tcctggtatt ttgccggcgg agaaaaatca aatgtgcttg aaataggttt tatgaaaggg 3452941 agtacaaaaa tcagacccga tgatgcagcc atctcaaatg cttcaagaat gagtattttt 3453001 atgattgttg cggacaagat tgaggtgtga taatcaaata ggctgtagct atttaatagc 3453061 tacagcctat ttgcaacttt ctaagttttt tatcgatatt ccggaacatc aaaataaagt 3453121 gtataaccgt ccagcaatga atacaggctg tacatgcggt ttacttgttt gtacgcccag 3453181 ccgatgtctg ttgcgtattg atgtgtcgct gtagctgacc atctcatttt gtacagtgtg 3453241 tcttgattgt aagctgtgtt gtggatatac gatgagccta tgaatttagc tccgccgata 3453301 atggccgctt ctggtgtgaa ccagccctgc tcgtacgcat atttggctcc gtagtaattc 3453361 ggattgctgt cgtatgctcc aattccatac atgttgtata cggtttttcc gttataggtt 3453421 aatccattgg ctaaagcgga tgtcccgttt cctgtttcca gaagagcgtg tgagattaaa 3453481 tacagttcgt tgatgctata ttgattggcg gcatcgataa atgcctttgc tctccctgtc 3453541 aggatgcctt tacccgcaag cactttctga tttacctcag taacgctgag acccgctgtc 3453601 tgtgacagct tgagaaattg gaagtagtat ttgctgtctc tggaaaagtt attcggatcc 3453661 acgtattgaa ctacttcatc actgcttgcg tttcgccagc ccaaattgat cttagcccag 3453721 ccgtttatct gtccgatgac tttcacttta tcgccttttt taaactggcc gatcacgttt 3453781 gtcgggctga cttccggcgt tgaccggata tttagtacat cagccgtaac agttgatgtt 3453841 gctgtattaa tgtacgtgag cgatacgtaa gccgctccgt ctgtttgcgg acttactgtc 3453901 atttgttttt ggaccatatc acgaagcgag agattgtagt ttgttttcat gatttgcggg 3453961 ccgtttttga tcttcacgat agatgatgtc catccgtata attgttttag cttcgttgat 3454021 gccgcagcag ctgtatcatt gcctgtgaac tgctcattta cgctgatttt ataaagcgta 3454081 ttgcttttcg ttgtatagct cggggttaca cttttcgatt taagataggt taacccattg 3454141 ttcaatgcgg ttttgctgct aagctgtgtt gtcacgattt tgtattgtgt atatgcagtc 3454201 tggcctgttt ttgatgttgt gactgcgata tgattttgtt tgaaaaatgt taaaacgcgg 3454261 tcaatctctt cttggctgat gatagcttca gttgtgattt gatagctgct cgcagctgtc 3454321 tgaccggttt tctggcttgc tactgatata tgattcgatt tgaaaaacgt gagtgcctga 3454381 ttgactttcg tttgatcaag cagagattcg gttgtgattt taaacgtgtc agctatttgt 3454441 tttttgacgg atttcgcaga agcacttagc tgatttttct ttaatatgtt caaacccttt 3454501 gtgacttttg cttgatctga tgtttcttct gagatgagct gatattgatt ttctgctgtt 3454561 gatccagctg ctgtttttgc agcttttact tttttctgag caaagaaggc tgctgctttg 3454621 tttgcttgct gctcgcctaa aatctttgcc gtcgtgattt gataagctgc agacgttgtc 3454681 gtttttttga cgctggatga cgtgtaatgc cattttttct ttttaaagaa agtgtctatt 3454741 ttttggagct gctgttttgt tatacccttc atattcacgg tatatgatgt gctttttcca 3454801 acctgttgat aactgccgga tacgccagtg tttttcttga tttggctgat ggcgtccttt 3454861 actgtactca gccctttgaa ataagctgat tggacattgt atgactcaac ggttgttttt 3454921 tgattgatgg acttgtagct gcctgtgatg ccagtgctct gtttcagctg ctgcaataga 3454981 gttttggcat tggcttcacc tgaaatggcg gcagttgtga acgtataata ggcttgccct 3455041 ttcactgttt cctttaatga tgcctgcagc ccagattcct tttggaaggc gtttttgatc 3455101 tgcgctgctc tgctgtctcc cacgattgtg ccagactgaa tggttgtgac agacaccgtg 3455161 tgtgtgatgg gctgatacga gcttttaatc cccgtttgct tggccaggct ctggataagc 3455221 gccttgactt ttgtctcatc agcaatgtct gatgtcatga cgttcatata gggctgagct 3455281 gctccgtaag cttttacagc gccagccact cccgtctcct gtttcagctt tgctaggata 3455341 gtgttggcct gtttttctcc ggagatggca cctgacgaga tggtgacata tggctgtttg 3455401 cttccaacag gacttgacgt tcctgtaatt gatgtctgtt tggcgagtcc gctcagtatt 3455461 gctttcgctt ctgattcgct atgaatgcct gaggcggaaa tttggtaggt cgttgttgtg 3455521 cctgaagcct gataggatgc atcccagcca gtatcttttt ccagtttggc gacagcttgt 3455581 gaggcttggc tttctgtact gaacgtattc gacggctcta ctttatatag tgagtagtcg 3455641 gtatacgcgg ctgcctgggc agaaccagac atggcaaaaa aggcaaggga cgcggcggat 3455701 agaagcatag gtgcgattag tctctttttc attccttctc ctctttctta ttctatgagt 3455761 atataaaact agtttattta tcggcacgcg catgcttcat ttataggtga atcacttcca 3455821 ttttctaata aaaaaactta acctcgaagt gagattaagt ttaaatatga gacacgataa 3455881 gggtacaagt tccttttatc gtaaaatcgg gcatttgagc cggcaaaata aagtgatcac 3455941 cttttttgag cggacatgtt ttgtcctcat acttgagcaa accgcttcct tctatcacgc 3456001 tgcaaatcag aaaggattca tcctgagcca tttcagcttc gccattgatg tcccatttat 3456061 aaaccgaaaa atattcccct tggacaaatg ttttaatggt tattcctttt cttgattctg 3456121 tcgattcatc tatatacccg tccacatggg gaaccgtggc ggcattgacc gctttggcaa 3456181 aatgaagctc tctcggactt ccgttgctat caagacggtc ataatcgtac acccggtatg 3456241 tggcatctga attttgctga gtctctaaaa caagggcccc cttgcacaat gcgtgcagcg 3456301 ttccgctcgg cacataatag aaatcacccg gtttaatttt gattcttcgc agcaggccct 3456361 cccagtcacc gctgttgatc attgtgacaa gttcggtttt tgagcgggcc gtatgcccgt 3456421 aaatgatttc tgcgttttcc ttacagtcga taatgtacca gcattccgtc ttgccgagtt 3456481 ctccctcttc gttttctccg gcatagtaat catcagggtg aactttaatt gacgtatctt 3456541 ccttcacatc cagcagcttt gtcagaagcg gaaaccgatc cccctctacg ccgccgaata 3456601 cttcacggtg ctcttcccaa agctcgatca atgtctttcc tttatacggg ccatttgcaa 3456661 cagtgctcgg tccttttgga tgagcggaaa tggcccagca ttcccccgtt gattctgaag 3456721 gaatactgta tccaaatcta tctcgtaaag cggttccgcc ccagattttt tctttaaaca 3456781 caggcgttag aaaaatcggt gattgcgtca tgatccgtac ccctcccctg taaataactg 3456841 atcatcattt tcccggtgcg cccctcttac aaacgcccgt ataagctgcc tttttcctat 3456901 gacaacatat gtacaaagca tcatcttttc attacccctt caaagaaaac gcttcctatc 3456961 tattatatca cgtcgaaaag aagctttgtt tcagcctttt cctcgataag aataattctc 3457021 cttttttgat acaaattaat aaaaaccgtc aatatgttta agaaggagag aaactatgca 3457081 aatcgactct gatctccaga acaatttaga cacactgaaa aaaacattgg gacaaaacga 3457141 cgatatgatg ttttatacat ttgctttcgg agatagcaga caaaaggcgt gtttactgta 3457201 tattgacggt ctgacagaga ataaaatgct ggcgcaatac gtcatttctc ctttacaaaa 3457261 agaggcgttg gcccataagg aatgctcgat tgaagactta tccgcctttt ttttcggctt 3457321 tcaccacagc gttgtttcta caatgaaaga aatagagcag ctcgtttttt cagggcaagc 3457381 cattttgctc gctgatggct atcgcggagg attagctttc gacacaaagt cagtcgcaac 3457441 acgcagtctt gatgaaccct cctccgaagt cgtggaacgc ggccctaaaa taggatttat 3457501 tgaaaagctg cggacaaaca cggcgctttt gcgtgaacgg acgagtgatc ctaatctcgt 3457561 catcaaagaa atgacactcg gaaaaaggac caaaaagaaa atcgctgtcg cttatattca 3457621 ggatatcgcc ccagattatg tcgtcaaaga agtgtttaaa aggctgaaat cagtcaatat 3457681 agataatttg ccggaatcgg ggacgcttga acagctgatt gaagacgaac cattttcaat 3457741 tttccccaca atattaagca cagaacgacc ggaccgggtc gaaagttctc tattagaagg 3457801 gcgagtgtcc atattagtgg atggtacgcc gtttgctttg attgtaccgg ctacggttga 3457861 cgaatttatt cattcgcccg atgattacag ccagcgctgg atcccaatgt cacttgtacg 3457921 ccttcttcgt tattccagca tcctgatcac catttatttg cccggtctgt atatttctct 3457981 cgtttctttt cacaccgggc tattgccgac tagaatggcc atttccattg caggcagcag 3458041 gcttaacgta ccattcccgc cttttgtaga ggcctttatc atgatcttta cgatcgaatt 3458101 gattcgagaa gccggattaa ggctgcctaa gccgattgga cagacaattg gccttatcgg 3458161 cggcgttgtc atcggacagg cagctgttca ggcgcaaatt gtcagtgcgc ttatggtcat 3458221 tgtcgtttct gtcacagcac tggcatcctt taccgttcct tcatacgcct ataactttcc 3458281 gctgcggatc attcggatcg gggttatgat aagtgcaaca gcgcttggca tgtacggcgt 3458341 tataatggtt tatctgtttg tgatcggcca tctcatgcgc ctgaaaagct ttggccagga 3458401 ttacattatc ccgatcatgg cgcagcctgg acaggatttg aaagacacag tcatccgtat 3458461 tcccacgatg tttttaaaaa gaagaccgac acgaaacgat cccgaagata acatcagaca 3458521 aaggtgatgg ctatgaggaa atcagagcat aaactgacat ttatgcagac gctcattatg 3458581 atcagcagca cattgattgg tgccggggtg ctgacccttc cccgctcagc cgccgaaacc 3458641 ggcagtccga gcggatggct aatgatactg ctccagggcg ttatttttat tatcatcgtt 3458701 ctgctttttt tgccttttct tcaaaaaaac agcggaaaaa ctctttttaa gctcaacagc 3458761 attgtagctg gaaaattcat cggctttcta ttgaatttat atatctgtct atatttcatt 3458821 gggattgttt gctttcaagc tcggattttg ggagaggttg tcggattctt tttgttgaaa 3458881 aatacgccaa tggcagttgt ggtgtttata tttcttgcag ttgccatcta tcatgtaggc 3458941 ggaggcgttt attcaattgc aaaagtatac gcttatattt ttcctataac ccttattatt 3459001 tttatgatgc ttctgatgtt cagctttcgc ttgttccagc ttgattttat ccggccggta 3459061 tttgaaggag gctatcaaag ctttttctct ttattcccaa aaacattatt atatttctcc 3459121 ggatttgaaa tcatttttta cctggtcccc tttatgagag atccaaagca agtgaaaaag 3459181 gctgttgctc tgggcatcgc gacttccaca ttgttctaca gcattacttt gctcattgtg 3459241 attggctgta tgactgtggc tgaggcaaaa acggtgacat ggccgaccat ttcccttatt 3459301 cacgcattag aggttccggg tatttttatt gaacgatttg atttgttctt acagctgacc 3459361 tggacagccc agcaatttgc ctgtatgctc ggatccttta aaggcgccca tatcgggtta 3459421 acggaaatct ttcatctaaa aaataaaaac aatgcatggc tgctgactgc aatgctggct 3459481 gcgacgtttt tcataacgat gtatcccaag gacttgaatg acgtgtttta ttacgggacg 3459541 cttcttggat atgctttctt aattgtgatt acaattccat tcttcgtctg gtttttaagc 3459601 tggatacaga aaaaaatagg gagggggcag ctgcaatgaa aacagcatca aaattctccg 3459661 tcatgttttt tatgctgctg gccctctgcg gctgctggga tgtcaaagat atcgagcaac 3459721 tatccttcgc cagagggctg gcgatcgatg agacaaatga tcaccagtac aaactgacgt 3459781 atcaaaatct tcttccccaa agcgaagaca gccaagcatc cggaaaaccc gaatttgtta 3459841 atgtaacgtc ccacgggaaa acgattctgg aagcagtcag tgatgtatcc atcaaggacc 3459901 ctcctgttta tagcgatcat ttaaaagtga tccttctggg agaaaaactg atgaggaatc 3459961 aaaatgtaga ccaagtcctc aaccacttta tccgggatga tgagctgcgg cgaagcagct 3460021 atttgatggc agccagaggg aatgcagctg atgttttcac aaaaggaaac cccaatcagc 3460081 agcagccgat gccctccgaa aaactgattg atttgacaac tcacagcgga tataacggta 3460141 agattatgat accgctgcgc atcggaagag cttctgtcta ctctcagaac gggtacagtt 3460201 atcttattca agccgtgaaa aacgaaaagg gaaaagccaa gtatgacgga gcaggcatta 3460261 tcaaaagggg cagcaataaa ctcgttgggt ttctttcagc tgatgaaacc caaacactgt 3460321 catgggtcat ggggacgatc caaggcggtg tcatgccgac gacagataaa ggacatccga 3460381 ttacgtttga aattaaaaag tcgaaaacga aaattaagcc cgtcattgaa aacggaaagc 3460441 ctgtctttca tatttctgtt aaaacgaagg gcatcctgac agaagaccaa aacccgaatg 3460501 aaaactcctt tagcaaaagt tatttgcaca ggctggaaaa catttttgaa aaaaagcttg 3460561 aacgagatgt aaagcaggtg atggataaac tgcagcacga gtataaaacc gatccggtct 3460621 ttttatcaga ccacataagg attcaacacc ctgactactg gaataaagta aaagggcatt 3460681 gggatgaaat attttctgag actgatttta agtacgatat ttcttttaaa atcattaact 3460741 ttggcacggt gggaaagtaa gcaatcaaaa gggtgcgcat gatcgcgcac ccttttttat 3460801 gttccgacag tctgctgttt tccggccgct cctccctgtc cgtttttgtc ccgtaaatcc 3460861 tgctcaattt cttcaaggct tcttcccttt gtctctgtca ctttaaatcg gacaaataag 3460921 aacgccatga taccgatcgc ggcataaatc aggaataaat aactgattcc gatcgcttcc 3460981 attaatattg gataggttaa tgaaacaatc agtgtcccaa cgtgcaacat taaggtcgaa 3461041 acaccggtcc cgattcctct gacgtgaagc gggaacaatt caggaagcat cacccacaca 3461101 accggtcccc agctgaccgc aaagacaacg ataaacacgc ctaaacaaat gacggtcgtc 3461161 catgaggcag ccggagtgtt atcgaaaaag agatttacta aagcgagaac gatcaagctg 3461221 atcaccatgc ccgcattccc gaatagcagt aacggctttc ttccaatctt gtcgatgatt 3461281 ttaatcgcta ctaatgtcat gagaacattg actgtgccga ttccgaccgt gcctaaaatc 3461341 gaagcggagt ttccgaatcc gacgtttgta aaggtctttg gcgcatagta gatgatcgta 3461401 ttcgttccga taaattgctg caaaaaagcg agtcccaaac ctgcaataag cgctgggcgc 3461461 acccatggat cgaacagctc cttcagaccg ccttcatcct gcttttccgc ttcttttata 3461521 tcatgtattt cctgatcaat atcttttgtg ccacgcaatt tttcaagaat tttcttcgct 3461581 ttgctttctt cgccattcgt gaacagccag cgcgggctct ccggcataaa caaaatgcca 3461641 ataagcaaga gcaatgacgg cacagcagcc aatccaagca tccagcgcca cgcttcggca 3461701 tcggcaaata tgtaattgac aatgtaagaa agaaggatgc cgaccgtgat catcagctga 3461761 ttcagtgatg acagcgcccc gcgtttatgt tttggcgcca gttcagataa ataaaggggt 3461821 acgattgtcg tcgatgttcc gactgcaagt cccaaaatga tgcgaaacag caccatgact 3461881 cctgtatttg gggccagtgc cacaccaaga ccgcctatac aaaacagcag cgcggctgcc 3461941 ataattgctt tttttcttcc gaaacggtca gtcagcttgc cggccgctcc tgagcccaat 3462001 atcgccccaa ccagcaagga gctgacaaca agaccttctg taaacgcgtt taagcctaac 3462061 tcctttttca taaataaaat agctccggaa atcactccgg tatcatagcc atataacgcg 3462121 cctccaagag ctccgaaaaa ataaagccat atatttgact gctttttcat aaagatgact 3462181 ccctttctcc atcagctgca atgacattgt ctgtgggatt tttttagaaa tcttttagcc 3462241 tctttttccg gccattaaac ctttttattt ttctgatcat aagttttcca atcatttact 3462301 tgtatttttt tcaatgtcgc cgaaacattt tacctgctgc ggcgtccaat ataaggtgat 3462361 tcagtacatt atcgttatca attttcaaaa acaagaactt ataaatatag gaatatttat 3462421 cgaaaaatgt ctttcgagta gttgccccat ggcaaataga atggtacgct tcaaatatta 3462481 aagaaacgtg aggtattgat atatggaaga acgatcacag cgcagaaaga aaaaaagaaa 3462541 actaaaaaaa tgggtgaaag ttgttgccgg attaatggct tttttagtca ttgcggcagg 3462601 ctctgtcggc gcctatgctt ttgtaaagct gaacaatgct tctaaggaag ctcatgtcag 3462661 ccttgcacgc ggagaacaat ctgtaaaacg gatcaaagaa tttgatcctg gaaaagattc 3462721 tttttctgta ttgctcttag gaattgatgc cagggagaaa aacggcgaga ccgtcgatca 3462781 ggcaagaagt gacgcgaatg tgctggttac atttaatcgg aaagaaaaaa cagctaaaat 3462841 gctgagcatt ccgcgtgacg cctatgtaaa catcccaggc cacgggtatg ataaattcac 3462901 acatgctcac gcttacggcg gcgttgactt aactgtgaaa acagttgaag aaatgctgga 3462961 tattccagtc gattatgtcg tagaaagcaa tttcacggct tttgaagacg tcgtaaacga 3463021 gttaaatggc gtcaaagtaa ctgtaaaaag cgataaagtc attcagcaaa tcaaaaaaga 3463081 tacaaaaggt aaagtcgttc ttcaaaaagg aacacatacg cttgatgggg aagaagcgct 3463141 cgcttacgta agaacacgta aagcggacag tgacctttta cgcgggcaaa gacaaatgga 3463201 agtgctgagc gccattatag ataaatcaaa atcattgagc tcaattccgg cttatgatga 3463261 tattgtggat acgatggggc aaaatttaaa aatgaactta tctcttaaag atgccatcgg 3463321 cctgttcccg ttcatcactt cattgaaatc agttgagtct attcagctga cgggttatga 3463381 ttatgaacct gccggagtct attatttcaa attgaatcag caaaagctgc aggaagttaa 3463441 aaaagagctg caaaacgatt taggtgtata atgaacggga tggcgattac gccatcccgt 3463501 tttacatatt tccttgttga aaattatcaa agtaacgttt agccttaatt tatatggatt 3463561 atgtttcaca ggcaagctga acatactaca cgaagcagct tcatttttaa ggaggttccc 3463621 ctacatatga aatgtattgc gattgatcta gacggaacat tactgaataa agaaagcgtc 3463681 atttctgcgg aaaacagaga ggcgatcaag cgggccgttg atgccggcat cctcgtcacc 3463741 atttgcacgg gaagagcgac atttgatgta aaagcgctgc tggatgactt ggacatccct 3463801 atcattgcag ctaatggcgg tacgatccac gacacgggtt accgtttgat cagccggaca 3463861 ttaatggatc aggaagccgg taaagcgatt gctgattact tactttcaaa aaacatttac 3463921 tttgaggtat atacagatga ccatctgctt tctccttttg acggcgaagc taagctgcac 3463981 gcggagcttg acattctaaa gagcgcaaac ccaaacgagc agacggatga cttgtggcaa 3464041 ggagccatga ctcaattcaa acagtttggc attaaaccaa tccctcatat cgaatcggtt 3464101 tttgacggcg gtgaaaacat ttataagctt ctttgcttct cctttgatat ggacaagctg 3464161 aaacaagcga aggaagaact gaagcatcat aaaaaactgg cgcaaacctc ttcaggaaaa 3464221 catattatcg aaatcctgcc ggcctcgtca ggaaaaggac gcgcgttaac aaagctggct 3464281 gacatatacg gaattgaaac acaggatatc tatgcgatcg gcgatagtcc aaacgatttg 3464341 tccatgtttg aagtcgccgg acaccgtatc gccatggaaa atgcgattga tgaattaaaa 3464401 gaaaaaagca cctttgtcac aaaaagcaat gacgaaaatg gtgtggccta ctttatagac 3464461 cagcttcttt cggggcaata tgcataaaga aaagactcca gagattggag tctttttctt 3464521 ttattgcacc cgtatacttc ctgcgtattt atccttccaa tatgtgctcg tgttcatatt 3464581 ggtaatggtc acgccgtttg ataatgtgac atgaacaact tgtccgtttc cgatatagat 3464641 ggagggattt aagcttgttg attgaaagaa cacaatgtct cccggcttca ggtccgcctt 3464701 ctcaatctta gttccggcat tgtactggct tgttgcgtat cgaggcaggg aaataccggc 3464761 tgctttctgg tatacatatt ggacaaatcc agctgtatca aatcccgtct caggtgttac 3464821 tccgccctgt ttgtaaggca cttctccgac ataaagcgtc gcttcggaaa caatcggatt 3464881 ttctttcggg attgtcaggt tgtcaaatcg gcgaataccc gtcatcttcg atttccagta 3464941 atcctctgac aaataggaaa tggttacttt ttctgaccgg cttgcctgaa tgaacctgcc 3465001 tgcgcccgca taaatgcctg catgtgaaat tcccgtttta tacgtattgc tgaaatagac 3465061 gacatcacca ggctttatgt tctgaggggc taccttctcg cccactgccc actgctgttc 3465121 ggctgatcgc ggtagataaa tgccgagtgc ctgttgaaac acatattgca caagccccga 3465181 gcaatcaaag ccctctgacg gcgtgcttcc gccaaacaca tatgggacac cgatatattt 3465241 ttcggcctcc tgaacgacag gaacatcagc cgttgccgga tcggcagcga ttcgtctcgc 3465301 cccgatataa gttccgctcc aatagctgct ttttttgtaa ttggtgatga taaccccttt 3465361 tgactgtgta ctgtgaacca tttggccgtc tccgatataa agggcgtcat gtgtcggaac 3465421 agtgccggtg cttccctctt tcttgaaaaa caaaatatca cccggcttca ggttttccgg 3465481 ttttacagct gttccgattt tatactggtc gtttacagat ctcggcagat gaatatcagc 3465541 cttactgaac acatattgta tcaatcctga tggatcgaaa ccctctttcg gcgtttcccc 3465601 gccatattta tactgatatc caagcaggtt ttttgcttcg ctgacaatca attctgatga 3465661 tgtatcagct tccgcaatct ccgcttttgt cataattgga accaaaaaac aaatgataac 3465721 cgccacaagc aaaaacttct tccagtttgc cagtgtgttc acttttatta tctcctcctc 3465781 tttttgcagt tttaacatcg gtattttttt gaatatgtta agagactttt taatattttt 3465841 acagaatgaa tatgctgggc aaataaaaag agagtgtctc atcagacact ctcttttttg 3465901 aattatttat tggcgtttac cggttcttcc tgctgctgga ttttattcat ttccatatca 3465961 atcttctgtt tttcctgatc tgtcagctga tcattgaatt taaaagctga cataaacatg 3466021 aacacgatgg ctacggcaac aaacggccag atggctttga caaatttcat ctttatcact 3466081 ccgattattt agattttagt ttgtcactat gatcaatatc aaacgtcagt tttccgtctt 3466141 ctactttcca agcgaaatta gagtctttcg tcagttcgcg aataatggtt ttctgtttaa 3466201 ggctgtcttt tttcacaggc gcaggtgtcg cttcatggat atcgatcggt gtcacttcaa 3466261 agcgtcctgt tccatttttc ttcaggtgat actgaaccag tgcactgtct cttgttctcg 3466321 tccagccttg gtcaaagaca aagttgccga ggctgtagaa aatgacggtt ccgttatata 3466381 cttcaatcgg ttctaagacg tgcgggtgat ggccgacgat gatgtcagct cccgcatcag 3466441 acatggctct tgcaagctgg cgctggcggt catttggatc attgtcatac tcttgtcccc 3466501 agtgtgactg cacaacaaca atgtccgcat gttttttcgc ttctgaaatc atagggatga 3466561 agatttcagg atctgcgggc agcacgcccg gcgtattctt tttagccgcg aaacctttcc 3466621 cggacacatc ggtaaagcca agcgtcgcaa tcgttacccc gttgactttc tggtacgaaa 3466681 ttttcttttt cgcatcactt aagctgtatc ccgctccaac gatatcaaga ttttgcttcg 3466741 caaattctcc aagcgtatct ttcatgccct gaacgccgta atccattgcg tggttgttgg 3466801 cgctgttgag aaccgtgaaa ttcatatcct tcaagacttt cactgattcc ttattcgtct 3466861 gcagatgaat ctctttatct gcttgtttat aattcttttg ataggttacc gggttttcaa 3466921 agtttcctgc tacataatcc gaggctctaa agatcggttc aacatattga aaaatactgt 3466981 ctgccccttt ttgctccgtt actttttcaa catagcgtcc catcataata tcgcctacaa 3467041 atgaggctga gagtacgtcg tcagaatacg ttttgacctt cggcgtttcc gcttttcccg 3467101 cccacatgaa agcgaacata aggacaaaaa cgatcggaat ggcaataaat acgtgcttat 3467161 tggttttctt tttttgctgt tttgtcagct ttagcagctt ttcatgaaag ctcagttctt 3467221 ttttcatcgt ttgacacacc ttacattaaa ttaagtagta aacaaacatg atagcaaagg 3467281 tcgctccgct caatagcagc gtgcttccga acgtaatggt taaaccttgt ttctgaatgg 3467341 tattggcaat taaacctggc acgatgatgc cgattcctcg aaattctgcg atttcaaatg 3467401 gtacaatcgg gtatagaaaa tcaaacgcga tttttaggac gatccctgtt atcagcatgg 3467461 cagcgaattt tctgcgtccg tacaaaatca taaatttgga taaaccgtat ttcacaatga 3467521 catacgtgag caagctcact agcaaaacaa gtaaaataaa gaccggctga ttaaacacaa 3467581 gtcctaaata tcccggtaca acaagtcctg ccggcacgat ccctgttttt tccgcaaaaa 3467641 ttaaactgag tagtacacct aaaattagtg cgatgtataa atctgatccg aacatgtctg 3467701 catttccccc tagcttacga gctgctttac cttgtattcg tggatttttt caattaaagg 3467761 ctctgcggca ccatgaatat tgccgacgcc atatatgaca cggttgtgca ttcttttctt 3467821 taacaattcc ataatttcat ctgttgactt atactctaga tcatgcagtt tgtctgcagg 3467881 aattttgcct tcttcgtagg cttttacgat cggttctgtt gtttcaccga ttaagatcag 3467941 ttcacttgct tcaatataag gcaatacgtc atttgcgaat tgctgtgtcc gatcgacacg 3468001 gtctgcgcgg cagttcatga tgatgatcgg atcatcggtc gggtaaccga tttcttttac 3468061 acgtttccat atattcaaag tagaagaagc gtcgtttgcg gcaaacccat taacaaagtg 3468121 cccaggctcg ctcggactga tcagcggaag aattctcatt gctcccggat ctggcggcgc 3468181 attcagcatt cccttaaatg ctgtttcttc gtcaatgccg agtgcttgag ccacacccag 3468241 cgccagagaa gcgttatcag ggaataccat gtattcaaat ttacgtaaat actcatctgt 3468301 aatttttgag ttatcagcaa tgatgacttt tgtgtttcgt tcttttgctt tttgtttaaa 3468361 gaactcggta tattcactat ctgtaatgac aagatggcca ttataaggaa ttgtagcagt 3468421 aaacgcttct gcaatttcat caagcgtcgg ccccatgaca tccatatggt cttccaaaac 3468481 attcacaatg acgccgatat tggcctgcag aagttcttcc tgaaagatga tttgataatc 3468541 tgggttaaca gccatgcatt cactgacaat cgcgttagcc cctctttcta ctgtttctct 3468601 catgacttct ttttgctctc cgatattcgg cccctgaggt ttccgtttaa tcggcttttc 3468661 ctccggtgtg tcccagtaaa tcattcttgc atctgttcct gttgtttttc caacagtctt 3468721 gtaaccggct tctattaata ttccggttgt cagccttgtc acagtcgatt ttccgcggat 3468781 gccgttaata ttcacccgaa cagggagggc atcaatgttt ttctgatgtc gtcgtttttc 3468841 taatattccg atgaccagta tgacagcaca ggctataatg agtaaccaca ttgcttttcg 3468901 acatctcctt ctatattgtt gtaaattcat tcatcagtat atagaatcac tatgaattct 3468961 caatcggcat tatgtaacat aatcttccct aatcgactaa gccaaacttc tcttttgaaa 3469021 gagattttat acctacaaac tgttttctat ttttggaaaa cagcaggact tataccttat 3469081 cactttttaa aaaaatcaaa gagaatgcgc tttcattttt ctcctgatat ccttctggac 3469141 gtatagtcac accctgctgt ttgtatttaa tatgcatttc aaatcaatct ttttttcagc 3469201 ctttgttatc aagcatttcc tgctatcatg cgtgtttccg gttcttatga acacaaaata 3469261 attttatcct gtttcttaag gacaaggtca taatgtcatc ctttctgcat ggaataagca 3469321 atatgaggcc cattccaaaa tgactaagga ggttcgagat gaaaacgcta aacatacgag 3469381 tccgaattct ctaacataat taaacatttt ctgggatgat agtcttttct gtttctcccc 3469441 atttacaggt ctaaacgcat gactttgaaa caattttaat aaaacttaat atttgttcaa 3469501 gaaatcttca tccatatttg tgaagacttt gtcaaaaaaa gagtgaaaac cttaaatttt 3469561 tcaattatat atacaattta caattagatt tcttttgata tttttattgc taacttcgga 3469621 ttgttcatga taatctatct atgtaaacgg ttacataaac aaggaggagc tgttttggct 3469681 acaattaaag atgtcgccgg agcggcgggc gtttcagttg cgacggtttc ccgcaacctg 3469741 aatgataacg gctatgtaca cgaagaaacg cgaacgcgtg tcatagcggc gatggcgaag 3469801 ctgaactatt acccgaatga agtcgccaga tctctatata aaagagaatc ccgactgatc 3469861 ggacttttgc tcccggatat cacaaaccct ttcttccccc agcttgcccg cggtgcggag 3469921 gatgaattga accgggaagg ctatcgcctt attttcggca acagtgacga ggaattgaaa 3469981 aaagaacttg aataccttca aacctttaag caaaatcatg tcgcaggcat tattgccgca 3470041 acgaattacc cggatctcga ggaatacagc ggcatgaatt atccagttgt ttttctggac 3470101 agaacgcttg aaggggctcc ttctgtgtcc agtgacggct atacaggagt aaagttagcc 3470161 gcccaggcta tcattcacgg aaaaagccag cgcattacgc tcttgagagg acccgctcac 3470221 ctgccgaccg ctcaagaccg atttaacggc gctttggaaa tcttaaagca ggctgaagtt 3470281 gattttcagg tcattgagac agcttcattt tcaattaaag atgcacaatc gatggcgaag 3470341 gagctgtttg cctcttatcc agcgacagat ggtgtgatcg cgagtaatga tattcaagcc 3470401 gctgccgttt tacatgaagc attgcggcgc ggaaaaaacg tgccggagga cattcaaatt 3470461 atcggctatg atgacattcc gcaaagcgga cttctgttcc cgccactttc tacaattaaa 3470521 cagcccgcat atgatatggg gaaagaagct gccaaactgc ttttgggtat cattaaaaaa 3470581 cagccgctgg cagaaacggc aattcaaatg cctgtcacct atataggaag aaagacgaca 3470641 agaaaggaag attaagatgc gtaatatttg tgtgattggt agctgttcta tggatttagt 3470701 ggtcacctcg gacaaacgcc caaaagccgg tgaaacggtt cttggcacgt catttcagac 3470761 tgtgccgggc ggcaaaggag caaatcaggc cgttgccgca gccagacttg gggcgcaagt 3470821 gtttatggtc ggcaaagttg gagacgatca ttatggaaca gctattttga ataatctcaa 3470881 agctaacggc gttcgcactg attatatgga accggttaca catacggaaa gcggaaccgc 3470941 tcatattgtg cttgctgaag gcgacaacag cattgtcgtt gtcaaaggcg cgaacgatga 3471001 catcacccca gcgtatgcgt taaacgcgct cgaacagatt gaaaaggtcg atatggtgct 3471061 gattcagcag gaaatcccag aagaaacggt tgatgaggtg tgcaaatact gccattctca 3471121 cgatatcccg atcatactaa acccagcacc ggcccgcccg ctcaagcagg aaacaattga 3471181 tcacgctacc tatctgacgc cgaatgaaca cgaggcttcg attttattcc ctgagcttac 3471241 catttccgaa gctctggcgc tttatccggc aaagctcttt attacggaag gaaaacaagg 3471301 cgtccgctat tcggctggca gcaaagaggt gctcatcccg tccttccctg tagaacccgt 3471361 tgatacaacc ggagccggtg atacgtttaa cgcagcattt gccgtggccc tggctgaggg 3471421 aaaagacatt gaagccgcat tgcggtttgc caatcgtgcc gcttcccttt ctgtctgctc 3471481 cttcggtgcc caaggcggaa tgccgacaag aaatgaagta gaggagctgc tgtcatgaaa 3471541 aaacacggta tactgaacag ccatcttgcc aagattttag ccgaccttgg ccacactgat 3471601 aaaattgtca tcgcggatgc cggactgccg gttcctgacg gcgttttgaa aattgatctt 3471661 tcactgaagc cgggccttcc ggctttccaa gatacagcgg cagtactggc tgaggaaatg 3471721 gcggtcgaaa aagtcattgc tgcagctgaa ataaaagcat ccaatcagga gaatgcgaaa 3471781 tttctagaaa atcttttctc tgaacaagag attgaatacc tttctcacga ggagtttaag 3471841 ctgctgacaa aagatgcaaa ggcagtcata agaacaggag aattcacacc atatgccaac 3471901 tgcatcctgc aggcaggtgt acttttctag aaaggaagat gaaacatgca gattgaaatg 3471961 aaagacattc ataaaacatt cggaaaaaat caggtgctgt caggcgtttc ctttcagctc 3472021 atgcctggcg aggttcacgc attaatggga gaaaacggcg ccggcaagtc cacgcttatg 3472081 aacattttga caggcctgca caaagcagat aaaggtcaaa tcagcataaa cggaaacgaa 3472141 acgtattttt ccaatccgaa agaagcggaa cagcatggaa tagcctttat ccatcaggaa 3472201 ttgaatatct ggccggaaat gaccgttctt gagaatctat ttatcggtaa agagatatcc 3472261 tccaagctgg gcgttttaca aacaagaaaa atgaaagcgc tagcaaaaga gcaatttgac 3472321 aaactttccg tctctctttc tcttgatcaa gaagccggcg aatgttccgt cggacagcag 3472381 caaatgatcg aaattgcaaa agcgcttatg acaaatgccg aggtaatcat tatggatgaa 3472441 ccgaccgcag cgttgactga acgtgaaatc agcaagctct ttgaggtcat tacagcgtta 3472501 aaaaagaacg gcgtctccat tgtctatatt tcgcatcgca tggaagaaat ttttgcgatt 3472561 tgcgacagaa ttaccatcat gcgtgacgga aaaacggtag atacaacaaa catctcagaa 3472621 actgattttg atgaagtcgt caaaaaaatg gtcggacggg agctgactga acgatatcca 3472681 aaacgcactc cttctctcgg tgacaaagta ttcgaggtga aaaatgcttc cgtaaaaggg 3472741 agttttgagg acgtcagctt ttatgtgcgt tccggtgaga tcgtcggtgt ttcaggatta 3472801 atgggagccg gccggacaga aatgatgaga gcgctgttcg gcgttgacag gctggacacg 3472861 ggtgagatat ggatcgctgg gaaaaaaacg gctattaaga acccgcagga agccgtgaaa 3472921 aaaggtctcg gctttattac agagaatcgc aaggatgaag ggctcctgct cgacacctcg 3472981 atccgcgaaa atattgccct gcccaatctg tccagcttct caccaaaggg tctcattgat 3473041 cataagcggg aggctgaatt tgtcgatctg ttaatcaagc gcctcactat caaaacagca 3473101 tcaccggaaa cgcacgcacg ccatttatca ggaggaaacc agcaaaaagt ggtgatagcc 3473161 aagtggatcg gcatcggacc gaaagtgctt atcttggatg agccaaccag aggtgtggat 3473221 gttggcgcca aacgagagat ttatacgctg atgaatgagc tgaccgaacg cggtgtcgct 3473281 atcatcatgg tgtcatcaga gcttcctgaa attctgggaa tgagcgatcg gattatcgtt 3473341 gtccatgaag gcagaatcag cggcgaaatc catgcgcgag aagcaacaca agaacgaatt 3473401 atgacacttg ccacgggagg gcggtaatat gaaaacggaa caactgcaaa cagaacaaaa 3473461 acggattcac ttcgacggag tcatgcaaaa actcggcccg tttcttggtt tatttattct 3473521 cgttatcatt gtatctattt taaatcccag ctttcttgaa ccgctgaata ttttaaacct 3473581 gcttcgccag gtcgccatta acggattaat cgcgttcggg atgacctttg ttattttgac 3473641 aggcggcatt gatctttctg ttggcgctat tcttgccctg tccagtgctt tagttgcggg 3473701 gatgattgtg tccggtgtcg atccggttct cgcgatcatc cttggctgta tcattggtgc 3473761 cgtactaggc atgatcaacg gattattgat tactaaagga aaaatggcgc cctttatcgc 3473821 cacgcttgcg accatgactg tgtttcgcgg actgacgcta gtgtatacag atggaaatcc 3473881 gattaccgga cttggcacaa actacggttt tcagatgttc ggacgcggtt actttttagg 3473941 cattcctgta ccggcaatta cgatggttct tgcctttgtc atcctttggg tgcttcttca 3474001 taaaacacca ttcggacgcc gaacgtacgc tatcggcggc aacgaaaaag ccgcgctcat 3474061 ttcaggcatc aaagtgacgc gcgtgaaagt gatgatctat tctttagccg ggcttttatc 3474121 cgctcttgca ggtgccatat tgacttcccg cctgcattcg gcccagccga ctgcgggaga 3474181 atcgtacgaa cttgatgcta tcgcggcagt cgtcttagga gggacaagtc tttccggcgg 3474241 ccgaggacgc attgtcggca cgttaatcgg ggtgctgatc atcggcacac ttaataacgg 3474301 acttaatctg cttggcgtct catcatttta tcagctggtt gtcaaaggga ttgttatctt 3474361 aattgcggta ttgttagacc gcaagaagtc agcttaggag ggttttacat gaaaaaggct 3474421 gtatccgtca ttttaacgtt atcattattt ttgttaaccg cctgttcgct tgagcctccc 3474481 caatgggcaa agccatcaaa ctcggggaac aaaaaggaat tcaccattgg cttgtccgtc 3474541 tcaacgctta ataatccttt ttttgtctca ttaaaaaagg gtatcgaaaa agaagctaaa 3474601 aaacggggaa tgaaagtcat cattgttgat gcacaaaatg attcatcgaa acagacgagt 3474661 gacgtggaag atttaattca gcaaggtgtt gatgcattat taatcaaccc gactgattct 3474721 tcggcgatct caacggcagt agaatctgca aacgcagtcg gtgtgcccgt cgtaacaatc 3474781 gatcgatctg cggaacaagg aaaagttgaa accctcgttg cttccgataa tgtaaaaggc 3474841 ggtgaaatgg ccgcggcgtt tattgccgac aaacttggaa aaggagcaaa ggtggcagag 3474901 cttgaaggcg tccccggcgc atctgccaca cgggaacgcg gctcaggatt ccataacatc 3474961 gcagaccaaa agctccaagt tgtcacaaaa caatcagctg actttgaccg cacgaaaggc 3475021 ctgactgtca tggaaaacct gctgcaggga catcctgata tccaagctgt ttttgctcac 3475081 aacgatgaaa tggcgctcgg tgctctcgag gcaattaaca gctcggggaa agacatattg 3475141 gtgatcggtt ttgacggcaa taaagatgcg ctcgcttcca ttaaagacag aaagctgtca 3475201 gccaccgtcg ctcagcagcc tgaattaatc ggtaaattgg ctacagaagc agcagatgat 3475261 attttgcacg ggaaaaaagt gcaaaaaaca atatccgcgc ctctcaaact agaaacacaa 3475321 aaataattgt ctgatgttta ggaacctgcg ataacgtgaa tagagatata gaatgaatta 3475381 tttctcttac gtgaggagag gaacggcatg aacaaaccaa caaaactatt ttcaacatta 3475441 gcacttgcgg ctggaatgac tgcggcggct gctggcggcg ctggcacgat ccatgctcaa 3475501 cagccagaaa caacggtaag cattgatgat ttatacagtt atccgattga ttcttatttg 3475561 gtatcagcag aggctctaaa tgtcagaacg aagccttccg catcaagcca gaaagccgat 3475621 acgctgcact taggagatag cctaaagctg atttccttct caaatgctga ctgggcaaag 3475681 gttaagtata aaaatggaaa aacaggattt gtatccactc attacattgt taaagcagcg 3475741 acaacggtaa aaaccaaaac aaaaacaaaa gtgtatacat ccgctgacgg aaagagcatt 3475801 aagactcttc cagcagacac aagcgtttct tttttaggct ggagtaaaac gaataaaggc 3475861 ggttttgatt ttgattgggt attcgttgat tacggcggta cgacaggtta tatgaaaaca 3475921 aaggatttac acatgacaaa ataactgaga gggattccgc ataaatgcgg aatccctttt 3475981 attatgaatt gatttgtcac attcccaaga tatttctcag gaaatattgt cgtatgctgt 3476041 gtcgaaacct tacatgatca tcgacatttt tgttcacgct aaaaagcgga ggtgtaaata 3476101 tggatcaatt tgaagcagca tatgaatcgt ataaagcccg gcaaacaact gccgatcaag 3476161 aaaatgttcc atctggaaaa gaagaaatta ttgcggttag aagaaatgag gaagacaata 3476221 ttatcgcagt gaaaaccaat acaggaagag agctcgacta ccctactgcg ctgtcagaag 3476281 caaaatcagg aaaactcgct catgttgatg tcttccataa atacgggcgt gacattttgc 3476341 gaagtgaacc ggacggcatc aaggaaaata acctgtctga gctgccggat ttttaaacaa 3476401 atacagccct gccgtatgtt ggacagggct gtattttaaa caaaaggctg ctggatgtat 3476461 tcggctaacc gttttgcact gtgagaaata tcctctgcag ctgcataatt cacgccatag 3476521 aacacatatg gaggcagata cttcatgccg atcagattac tcgtggcctg aaatggtttc 3476581 aatagctcac tgatcgagta atgatttgct ccgcccgctt gatatttttc cgcttcgctc 3476641 cctgttgata cagccagcat cagctccttg ccatgcaagg catttccttc tgaaccaaaa 3476701 gcccagccat aagtcagcac aagatcctgc cattttttca agagcggcgg agagctgtac 3476761 caatatagcg ggaattgaaa gacaatccga tcgtattcct cgcacagctg ctgttccttc 3476821 gcaacatcta tcgcttcatc cgggtattcc ttataaagat cccgtactgt gatattgtca 3476881 tgtttactca attcctcagc ccacgcctta ttaacaactg aggtctccat atgaggatgc 3476941 actgccaaaa ccaatatttt catcagacca cacctttact gttttgatgt tattttatct 3477001 aaaatcagga aaagagccaa ataaaaagaa agccctgcta aaaggggctt tctttttttc 3477061 ttttattcag ggcttccttc agttgtttcg atatctttcg caaaatcagg gttatccaga 3477121 ttcgcattaa agaaatccgc tgtgttcgga agtctgagat tcatgttcat tttttgagaa 3477181 atcgtaaccg tgcaatcctc aagcacatag tcaaaaacgt gtccgcctga attgcgtcct 3477241 tcgtcaatga agtgcaggtg atagccagaa acggcgattc cgtttgcata agctggtgtc 3477301 aagaaaccta caatcgttcc tctcacgttg tcgaagttga aaatcggctg tgttttgacc 3477361 gcttcaacca ttggcacgta aggtttttct tgaagttcta ctgttcttgt ctgcaccttt 3477421 ttaaacaatc cgtcaatgcg aattgcataa aataagtttc tgcttggcag catgctgttg 3477481 atctcttttt caaagtcttc gcgtgtcatt ttcgcatcaa ttttgtgcgt catgtccggt 3477541 gtaaagaacg taaatgaaca gaacggtgaa cggtctccat tttggaccgg tgtcgcggtt 3477601 ccgtctgagc gaagacggta aaattcgccg tcaaacccaa tcagctctcc gtcaagcttg 3477661 ttaaaggttc cgataccgaa gtctccatat ttcggaatct ctgacagttc aaaatctccg 3477721 tcatatactc cgtctaatag agaagtcatt gttgatactt gataaatctg gctcacaggc 3477781 tgatcttttt gaccacggct gagcacttga atgttgcttt ctcgtttcat atttcccttc 3477841 actcctttta tttagtgctg ttcataaaac agtgtcgtga tgcgcagagt gctagagagc 3477901 tttcgttttc atgagttccc cgaattcttt cggaagcttg tcacttgcta aattaatgtt 3477961 atcactgtag tcaaccggga catcgatgat gacaggacct tcagcgttca tgccttgacg 3478021 cagaacatct gccagctggt ctggtgattc tacgcgcaag ccagttgctc cgaagctttc 3478081 cgcatatttc acgatatcga tatttccgaa atcgaccgca gatgtacggt tatatttttt 3478141 caattgctgg aatgcaacca tgtcatatgt gctgtcgttc catacaatgt gtacaattgg 3478201 tgcttttagt cgaactgctg tctctaattc cattgctgag aataagaaac cgccgtcacc 3478261 agagacagaa accacttttt ctcccggttt caccaatgaa gcgccgattg cccaaggaag 3478321 cgcaacgccg agtgtttgca taccgttact gatcattaat gttaacggct cgtagctgcg 3478381 gaaataacgt gacatccaaa tggcgtgcga accgatatcg caagttactg taacatgatc 3478441 atcgactgca ttacgcaact ctttaacgat ttcaagaggg tgcgctctgt ctgatttcca 3478501 atctgcaggc acctgctcac cttcatgcat atattgtttt aaatcagaaa ggattttctg 3478561 ctcacgctct gcaaattcca ctttcacagc atcgtgttcg atatgattga tcgtggacgg 3478621 aatgtcaccg atcaattcaa gatcaggctg gtaagcatga tcaatgtcag cgataatctc 3478681 gtctaaatgg ataattgtcc ggtctccatt gatattccag aatttcggat catattcaat 3478741 cgggtcatag ccgatcgtca gaacaacatc tgcctgctct agcagtaaat cgccaggctg 3478801 gttgcggaac aaaccgatac ggccaaaata ttgatcctct aaatctctag aaagggtacc 3478861 ggcagcttga tatgtttcaa caaatggaag ctgaaccttt ttcaaaagct tgcgaaccgc 3478921 tttaattgct tccggtcttc cgcctttcat gccgaccaaa acgacaggaa gttttgctgt 3478981 ttggattttt gctatggccg cactgattgc atcatctgct gcaggaccga gttttggcgc 3479041 tgcaacagca cgcacgtttt tcgtatttgt gacttcattc acaacatctt gcggaaagct 3479101 cacaaaagcg gccccagcct gccctgctga cgctatccta aatgcatttg taacagcttc 3479161 cggtatattt tttacatctt gaacttctac actgtatttt gtaatcggct ggaatagcgc 3479221 cgcattatcc aaagattgat gtgtccgttt taaacgatct gcacggatca cgtttccagc 3479281 aagcgcaacg acagggtctc cttcagtgtt cgctgtcagc aggcctgttg ccaagttaga 3479341 ggcacccggt cctgatgtga ctaacacgac tcccggtttt ccagttaaac ggccgactgc 3479401 ttgggccatg aatgctgcgt tttgttcgtg ccgggcaacg ataatttcag gtcctttatc 3479461 ttgtaaagcg tcaaataccg catcaatttt tgcacctgga atgccaaata catgtgtgac 3479521 accttgctcc actaagcaat caacaacaag ctccgcccct ctgtttttca caagggattt 3479581 ttgttctttt gttgcttttg tcaacaccct cactccttat tatgcatttt aaacgtaaaa 3479641 ttttaaatat cttgtgataa gtttcactat acactctttg gaaattgacc tccaatatcg 3479701 attcgcctta tgattaatat gtaatacgaa ttattaacct atggaaagga atgcatattg 3479761 aatggagctt cgccatcttc aatactttat cgcagtagcc gaagagcttc atttcggaaa 3479821 ggctgcccgg cggctgaaca tgacgcagcc tcctctcagc cagcagatca aacagctgga 3479881 ggaagaagtc ggagttacgc ttctgaaaag gacaaaacga tttgtcgagc ttaccgcagc 3479941 aggagaaatc tttttaaatc attgccgcat ggcattgatg caaatcggac aaggaattga 3480001 actggcacag cggacggccc gcggcgagca aggccttctc gtaatcggtt ttgtcggatc 3480061 agctacatat gaatttctgc cgccgattgt ccgggaatat cgtaaaaaat tcccatctgt 3480121 gaaaatagaa ctgcgtgaaa tatcctcgtc taggcagcag gaggagctac taaagggcaa 3480181 cattgatatt ggtatacttc atcctccctt acagcataca gctttacata tcgaaaccgc 3480241 ccaaagcagc ccttgtgttt tagctttgcc taagcaacac ccattgactt ctaaggaatc 3480301 aattacgatt gaggatttaa gagatgaacc aattattact gttgctaaag aagcatggcc 3480361 tactctatac atggatttta ttcagttctg tgaacaagcg ggcttcagac ccaacattgt 3480421 ccaggaagcc acagaatatc aaatggtgat tggtttagtc agtgccggaa ttggtatgac 3480481 atttgttcct tcctcggcca aaaaattatt taatttggat gttacttatc gaaaaatgga 3480541 ccaaatacag cttaatgcag aatgggttat cgcttaccgc aaagacaatc ataatccgct 3480601 tataaagcat tttattcata tttcaaattg tcagcagaca agaactaaag agagtgatgc 3480661 aggtacatga acaatacttg caatctcttt tttcttttgg gattcttatg gaatttttat 3480721 taatttaata taatcgctta gtacaacttt atatcagtat acgtatacat acagtacaaa 3480781 tagttggcaa ggacatcagt aagcgcagga cattagtttg attttaaaaa tgaaagatag 3480841 agaggtgaag taaattattg agttcaccgg catattcaca ttgctcgctt ttttcgtaac 3480901 aatgattttt attttctgga gaccaaaagg actaaatgaa gctatccccg ccacatttgg 3480961 cgctttaatg gttttattgt gcggaagtgt gtcattggca gacttagggg aaatcggaac 3481021 aaaagtcacg ggtgcatcgg ttacaatcct tgccactatg attatggcca ttgcactaga 3481081 aagctttggt ttcttttatt gggtggctgc aaaactgctc caacaatcca agggttcagg 3481141 catcaagctt ttttggctaa ccaatttgct ctgctttctc atgaccattt tccttaataa 3481201 tgatgggagc attttgatca caactccaat ccttttgctt gtactaaaat atttaggttt 3481261 aaaaaaacat caaaaagccc catatttatt aagcggtgtt ttaatagcca cagcctctag 3481321 cgcaccgatt ggcgtaagta atattgttaa tttaatttct ctcaaaatca ttggaatgga 3481381 tctatatctt cacaccgcca tgatgtttgt ccctagtatg atgggactca tttttatgac 3481441 ttgtctactg tttatgttct tttataaacg tcttcccaaa agcctgccag atataccggg 3481501 ccattttcag tctctgcggc atagaaggta ccatcctctt cattcgccat cagctccttt 3481561 accagaacga aatcaaacaa aaatcatgtt gtttgtgctt gcatttgttt ttctcgtcag 3481621 aatgagtcta tttgcagcat catataccgg tatttctgtt cctctagtcg ctgtcatcgg 3481681 atcttttatc ctgttgagct ggagatggat ttatttcaaa acctccccaa gagacttgtt 3481741 atataaatcg ccttggcaca tttttatatt cgcttttact atgtatgtct taatttatgg 3481801 tctgcataat attggattca cagagttact tgtgagttat tttgaacctg tggtttctgg 3481861 aagcctcgcc catgcaactt tcgcatcagg tatctctact tcagtttttt ctaatctctt 3481921 taacaaccat ccagcgttaa tgatcagtac ttttacctta actgaaatga ccctgaatcc 3481981 ttcaacaaca aaaatcatct acttggcaaa tattatcggc agtgatatcg gttcattatt 3482041 attacctatg ggaaccttag caacgcttat ttggatgcat atattaaaac agcatgatga 3482101 aagtatttca tggggcgaat atataaaaac gaccattatc atcattccgc tgactgttct 3482161 ttttacgtta acatgtttat atttttggat cagttggtta tttctttagc acagtatgaa 3482221 acgaaaaact gccttctgct tttcaagagg gcagttttgt atacactagg gaagatgcat 3482281 tgtctttaga tgatttaact tccaaatgac tggctctcca cttgcgttaa taagctcaat 3482341 gatattatta gagacaccct ttaatagtcc gactttttct ggcacctctc ccatatcaaa 3482401 tatgaccaat tcaccaatat tttttttgat ctgctcctca aaattacgca caagaggaac 3482461 tttggaaggc acgaccggca attgtgagtt gtcaagagta tacggtgttt gttcagttga 3482521 ataaggggta aaccatttta aatgatgcat agatataaaa agtattttaa atacgggtga 3482581 gaaaaataca atataatcgt ttaaaacatt tgtaacatat ccatggatcg atcgaccccc 3482641 agttacataa acttcaataa actggccttt gaccttgttt aatgtatttc tatatgaaaa 3482701 agcttgagtt tctgcctcta tcattggatc ttccggattg atcaaaaatg gcttctcagt 3482761 actggtcact attttcgcct tgtttatttg atgaagatgc aacaagggaa tataaagata 3482821 attgcagcca tcaaaaataa caaaaatatc ctgtccgata tctatgaggg tgccgacaaa 3482881 ccttgtatct cctgaaatga caacctcaac atctgtgtta aggaattgat tcaaaccttt 3482941 cacgattctc ctcctttaac tgaaaaaggg catcacttta tctgatgctc ctccattatc 3483001 tattaaaatt tacgtttcca gtgatagtct atcgttctga caatcgtttc atagctataa 3483061 tcttcctttt gttttcctga actttttatt gaacttgaat agcctggtga tcttgatgat 3483121 tgataatctg aagatcttgg tgatcgttta gatgattttg atgattgata atctgaagat 3483181 tttaatgatc gtttagatga ttttgaagaa ctttttgaac gtgacgaacg gccagatttg 3483241 gatgattgat aatccgaaga ttttagtgat cgtttagatg attttgaaga actttttgaa 3483301 cgtgacgaac gaccagattt ggatgattga tcatctgaag attttagtga tcgtttagat 3483361 gattttgatg agctatatga ttttgaagaa atgaacgaat tgctgtcctt atcattattg 3483421 tcttcctggt tttgttcatt tttttgatcc tcttttttgt acgacccttt tggacctaag 3483481 ctgatgcttt ttatgtgaaa aggatagatg cgaagcacct cttgattttt cactatagta 3483541 taatggccgt cggcattatc tacaaggata ccctcaatgg cttccggacc tccacgatta 3483601 attgaaaccc atttatgagt cagactctta aaaacctcgc ttaaatcatc agcttccaaa 3483661 actccaactg gcgtctgctc ttctattttc aaatcaggct cgtgtttact tatacttttg 3483721 atgtgatgga tattaaaata cactacccca tcctcatttg tgtttaacgc agcgtaatca 3483781 tctcccagcc agaccaatct tcctttttta gattccggac ccccttggtt aaattgaact 3483841 gattggttta ttaaatgtcc gattaagcta tgaaaatcat cagcatcgag catttcctca 3483901 gtctcaattg ttgtggtgct attattggta tcctcagtaa tacttttcac atgctccaac 3483961 tgataataaa ttattttttt ttcagcttgt aaagctatat aatctgattt tacagctgtt 3484021 aattttcctt ttttagattc cggacctcca cgatatacag taacaatttt atctttcatt 3484081 gagtgcaaaa agttataata cgatatttca ttatttgaat gatatttcat tctcctcttg 3484141 ctcattcaaa ttcctcctag tcacttatac atagatgata aacatactgc atatatacgt 3484201 gtcacattta tttgttgaac taattcaata gcctaattgt cgctttttcc gcgaataccc 3484261 attttcacgc attcataaaa tacttaaatg atctttgagg tattgtgaac ggtttttaat 3484321 atactcgcag atcacatccg gctcacggtc aaaacgctca atatcattct ttttatacgg 3484381 gtccatgagg acaaacggcc taatccgttc atacatcgcc atgattttcg gttccatata 3484441 ttctattgta aaaagagatt ggagcgtttt ttctaacagg cgcttgtagg acttgcgaaa 3484501 ctcggattca tccaatatcc gggcggttag tgtattaaat ccttgaattc ttacataatc 3484561 ggcagccatc cgctctccat ggatatccct gccccaagtc gcatcataat cccaaggaat 3484621 cacctcaaat aatccggttt ccccgcttct gtataatgcg tagttgtgga caaacccgtc 3484681 atagttcgag gtgaatacaa taccagcaag ccagcgcaaa tacttatcga catccacgtg 3484741 ttttgtcact tctgacttaa actgagcttt agggaccgta ttaattttaa aaatcatatc 3484801 ttgtaaataa aaatcatctt cctcagtccc tgttttcttt tcatatccaa gctccagcga 3484861 tgttttcgtt tccctttcta aatcgctcat cagagaaaag ttggcatcat catccaccgc 3484921 ataaaaaatc gcgccatcag ccagcttcct tttcgccaaa taatattcat ctacggattc 3484981 aagttcaaga taaacccctt cattcttccc attcatcttt acaaacgcaa actctgcctt 3485041 tggagacagt gtccctagct ccgagaaaaa atccagagac aatttgtttc tcatcaagga 3485101 agggtcttta tactccgcat ttaagtgaat ctctcgcgcg ccgcggaatg ttttcggctg 3485161 ataaaaggaa atatggtatg acttcttttt gaagtctctg atatgtgatc cccgataagc 3485221 gatatcaata tccagccttt tttgatttac cttcatcaca gctggcaccg gatcatcgtc 3485281 ccatatatcc ttttttaatt cacgcaagtc ttttggatga acaaacagct gataaagcgg 3485341 taaattggat tgattcttca tccataatcc tccttacaaa ttttaggctt ttatttttat 3485401 aagatctcag cggaacactt atacactttt taaaaccgcg cgtactatga gggtagtaag 3485461 gatcttcatc cttaacatat ttttaaaagg aggatttcaa attgggccac tattcccatt 3485521 ctgacatcga agaagcggtg aaatccgcaa aaaaagaagg tttaaaggat tatttatacc 3485581 aagagcctca tggaaaaaaa cgcagtcata aaaagtcgca ccgcactcac aaaaaatctc 3485641 gcagccataa aaaatcatac tgctctcaca aaaaatctcg cagtcacaaa aaatcattct 3485701 gttctcacaa aaaatctcgc agccacaaaa aatcatactg ctctcacaag aaatctcgca 3485761 gccacaaaaa atcgtaccgt tctcacaaaa aatctcgcag ctataaaaaa tcttaccgtt 3485821 cttacaaaaa atctcgtagc tataaaaaat cttgccgttc ttacaaaaaa tctcgcagct 3485881 acaaaaagtc ttactgttct cacaagaaaa aatctcgcag ctataagaag tcatgccgca 3485941 cacacaaaaa atcttatcgt tcccataaga aatactacaa aaaaccgcac caccactgcg 3486001 acgactacaa aagacacgat gattatgaca gcaaaaaaga atactggaaa gacggcaatt 3486061 gctgggtagt caaaaagaaa tacaaataat ctaagttttc attgtttcaa taggctgccg 3486121 gcggaggtac ggaagcctat ttttttattt gccctgtatt agatatatgt catgacataa 3486181 catatgcaac ccgcatcatt tggtttcctt taaaccattt cgttataatc aaggtatcct 3486241 aacgataaag gcggttgttg ctatgtacat atttcaagct gatcagctta gtgccaaaga 3486301 cacatacaag ctattgtcag gtaccgttat tccccgcccc attgcatttg tgacaacact 3486361 ttcttcagga ggagcggtaa atgccgcgcc tttcagtttt tataacgtcg tcagctcaga 3486421 tcctccgctt ctcagtattt ctgttaacag gacggaagga cgccaaaaag atacagcacg 3486481 aaacgcagtg gagaacggag aatttgtcgt tcatgtcagt gatgaagcca tcattgaaga 3486541 tatcaatgaa acagctgcaa gcttaaggcc ggatgaaagc gagcttacac gcacctcgct 3486601 tcatcctgtt gaaagcaaag ctgtttcagt tcccggcatt aaggaagccc gcgttcgctt 3486661 tgagtgcaaa ttagagcggc atattacctt tgacaatgat caaggcatca ctacagcaga 3486721 tctgctcatc ggaagagttg tctgcttcca cctagatgaa aaggtgtatg atgcagaaaa 3486781 gggatatatt ttaacggatg aattaaagcc tgcctcacga ttggcgggaa atcactatgc 3486841 caagctgggg gaagaattca cactgattcg tcccagctga agagaaggac tatttaaata 3486901 gaagaaacta gtcaaaaaga ccttatgatt acaaaatatc gcctgtaaat aactgaaaaa 3486961 atatcaaaaa aaagaacacc cagagcaagc tcggggtgtt cttttatgaa acgtttttcc 3487021 tttttcttcg tataaaggta gattaggagg aattggaatg acaaactttt ggattttaat 3487081 gctgatcgct attaccatca gtctcgcctc tcaatttttt ataaagaaaa aatacggtat 3487141 tgataaatcc ggctggcgat ataagcatgt cagcaataca cacaaatgga tcgaaatcac 3487201 tttacttatt ttgtttgtgt tttcactctc cttttttcca gttgaatatt tgcttctttt 3487261 attttttatt gtgattgact caatacgtat ttttatggag tggcattata gacctgaaga 3487321 taaacagtat atgtaccaca ttgtagaggt ctcccttatg tttatgcttt tgatttatgt 3487381 ttgtacccta tagttattta aatccccaca gccgctccgt ctccccgagg atcggctccg 3487441 ccttggagaa agccttcttc atcaactttg attgcagccg cttgtcccat cagcggatca 3487501 tagtcaccga caacctccac gagatgcccg ctgtctttca gtttttggat tgttttgtct 3487561 gtgaatctgc cctcgactct gagaccttcg tattcctctc cccacgttct gccccatacc 3487621 cagcgcggtt cgctgattgc ctgctgtgga tgcattccgt agtccagcat tcgggtaatg 3487681 atggccgtct gggtctgcgg ctggccttcg ccgccttgtg tgccgtacag aatttttggc 3487741 tttccgcctt tacagaccat agccggcatc aacgtatgga aggtgcgctt tctcggttca 3487801 agcgtgttga catgattttc atccagtgag aaaaacgatc cgcggttttg cagtaatatg 3487861 cctgtatcac cggcagtgac tgccgagcca aattcaaagt acaggctttg aatgaatgac 3487921 actgcgttgc catccgcatc gattacggcc gcatatgccg tatcacttcc caccggcctg 3487981 ctttctgccg gtattgcgag atagccgatt tcttctgcca attgttttgc ataacgtttg 3488041 tccaaaagcc tttcaagcgg aatgtctgca aacgccggat cagtcaggac ggcatcccga 3488101 tctagaaaac tctttttcaa tgcctccaca agcacgtgat aatactcaaa tgaaccgtgt 3488161 tcgatttggg tgaaatcata gttttccaaa atgttcagtg ttaataaacc ggtaaatccc 3488221 tgagaattcg gcggcgcctg atacacactg tatcctcgat aatcacttga tacaggcgct 3488281 gcccactcac cccgatgcgc tttaaaatca tcgattgtca tgtaactgcc gttattctgt 3488341 aaatgtgaga caatccgctg agcgagatct ccttcataaa atgcgcttct tcctttttca 3488401 gcaatcaagt tcagactgtc tgcaagctct ttttgcacaa accgctctcc cgggacaggt 3488461 gctttgcccc ttctcgtgaa gatgtcagcc gtgtaaggcg tggaagccag cagttcaata 3488521 ttcttttctg tgtgacgaca ctgatcagct gatacaggaa acccattttg ggcataatcg 3488581 cgtgcgggct ccaatacatc tgcaagagac agacgcccgt actccttcag gaccgcatcc 3488641 cagctatcaa ccattcccgg cacggtaata gcactgtcaa ttccccgcag cggaatcgcg 3488701 ctttttccct tatatacatc tctcgttacg ttttttcctg aacggccgct gccattgtag 3488761 acttttactg cctttgtttc ctggtgaaag gtcagccaaa aggaatcccc gccaagtccg 3488821 gtcatatgcg ggtacacaac cgcaagacaa gcactcaccg caacagcggc gtcaaacgcg 3488881 ttgcctccct tatccagtat gcggtttccg gcttgagaag cgagataatg cggactgacg 3488941 accatttgct ttgtaccgat gacagatttg ttcatcacaa gtcccctttt ttaagaaatt 3489001 ttcttcagta tagggagcct gatttttcac atctactgat ccggcagaaa aactgacgaa 3489061 ctttcttctt ttcgcaaata ataagatatt ttcgcattca tttcgaaaac aaatgaaaaa 3489121 ttattatttc tatacgtaac ttttatgata aaatgattgc taaaaggcta cgaaagcagg 3489181 tggagcaatt gagtcatgaa tatcaaatcc ccaaccttgt acttgatgag actgataaac 3489241 aaattctcac gattttgcat gaagaaggca gaatttctta tacggatctt ggcaaaagag 3489301 tcgatttgtc acgggtcgcc gttcaggccc gtatcaacca attaattgaa gccggtgtta 3489361 ttgaaaaatt caccgctgtc atcaatcccg ctaaaatcgg catccatgtt tccgtgtttt 3489421 tcaatgtcga ggtagaaccg caatttttag aagaggtcgc tcttaagctt gaggaagagc 3489481 ctgcggtcac cagcctttat cacatgacag gcccgagcaa gctgcatatg catgggatct 3489541 ttaccaacga tcaagaaatg gaagaattct taacaaaacg gctgtatcca ttgcgaggcg 3489601 tcgtcagtgt tgattgccag atgctgatca aacgatacaa aagccgtatg ggaatgaagc 3489661 tgtaaaggag agaaacaaat gaaaaaccat ccttatcggg atatgacggc cgcaatggtt 3489721 cgcaccggca tattagggtt cggcggcgga ccttccgtga ttccgctgat ccgccatgaa 3489781 gcggtcaata aatataaatg gattgacgat gatgaattcg gagaaatatt agcaatcgct 3489841 aatgcgcttc ccggaccgat tgccaccaaa atggctgctt atctgggctt taagctaaaa 3489901 ggcacattag gtgcaattgt ggcgatcctc gcccacattc tgcctacatg tcttgcgatg 3489961 gtgggcttgt ttgcggctgt aaatgtgtta agccattcag caattgttgc aggtatgatt 3490021 ggtgccgtca cgccggtaat tgcggtcatg ctcggaatca tggcgtacga gtttggccaa 3490081 aaagcgctta aaggtttcgg ctgggttacc ggcatcctgt tttttatcat cgcttttatc 3490141 ggcctgcaaa ctttacagat taatcccggc ctggtcatta tcattttctt agcttacggg 3490201 gcgtttcatt ttaaactgaa agacaaaatc acaaataaac attcaaaaga taaaggaatg 3490261 tcagcctcat gatatcgatc tatttattta tggcgttttt tatcgcaaac ctactgggat 3490321 atggcggcgg acctgcgtct atcccgctaa tgtttgaaga agtcgtaaac agatacagct 3490381 ggctctcaaa cgatcaattc tcaaatatgc tcgcacttgc gaacgcattg ccgggcccga 3490441 tcgccacgaa aatcgctgcg tatgtcggct acagcgcagg cgggtggccc ggcttcctaa 3490501 ttgccctgat cgcaaccgtc gtaccgtcgg cgctcgcatt gatcgtcctg ctgcgcatca 3490561 tccagcgctt ccgccaatca cctgtcatca aaggcatgac gctgtccgtc cagcctgtca 3490621 tcgcggtcat gatgctcatt cttacctggc aaatcggcgc agacggcatc aaagcgatcg 3490681 gctgggtcca atcgatcgtg attacgggaa tttcgctcct tgccatgaca aaattcaaaa 3490741 tgcatccggc atttttgatt attgcggcgt ttttatatgg gggccttgtg atcccttatt 3490801 tatagaaaaa agcacctgga caggtgcttt tttattttag cccagaaatg ccgtttgata 3490861 tgacagctgt ttcttctcct gcgtcactct tgatcatgtg cttgacttgc agcgtggttc 3490921 ctgccattct cacagattgc ttcaactggg acgaattggt ttcaacttgt atccaaacag 3490981 gaggctggac cttccaaaat aaatagagtg caagaatcag caagccagca atgaccgaca 3491041 gcaaaaactt catatcgcat cgcttctttt cagtaagcgg ctcgcagcgg acagcgcctg 3491101 atgatcacga agaatatcgc ctggacgatt gccttctccc agcacatagc ctttaaagga 3491161 cattcccata aaatgaaaaa tatgttcgaa ttgctgaatc agcggcagcc cttttatttt 3491221 tggattgtct ccgcccactg ctattacata tgcctgtttc actgacattt gctgtttaaa 3491281 atcaggaaat ctcggatctc tcaacgtctg tgaccagcga tcaataaaca gctttaatgt 3491341 ccctgacatg ccaaaccaat aaattggggt ggcgaatata agaatatggc actgcaatat 3491401 ccgttcaatg atagaatcgt agtcatcttg aacaggacga aagccgcctt gggcgtgacg 3491461 cagatcttca attggttgaa ttggatattt ctgcaaataa atgtgctccg catcgaatcc 3491521 ttgaacagcc ttctccgcaa gaacatccgt atttccgcca gaccgagttc cgccgttaat 3491581 aaccgcaatt ttcatgatgc atctgctcct ttgtttacga atgattttct tcatcatata 3491641 atggattcat caatcaatac agatgattat ttcgattaat ccaatcgcta aaaccgattt 3491701 agaaaggaag agaacaagtg gaattgaagc agctgatcac ctttattacg gcggctgaac 3491761 atgtaaactt caccctaacc gccaaaatgc ttaattatgc acaatcaagc gttacctctc 3491821 agatcaaatc acttgaagaa gaaatcggaa cgcctttatt tgaacggctc ggcaagcggc 3491881 ttatcttgac agaagcagga aaaacgttca aatcttatgc acagaagatc attgcgttaa 3491941 cagaagaagc gaaaatggcc acaaatcaag taagagaaac aaccggaacc ttaaaaatcg 3492001 gggcgacgga aagccagtgc acataccgcc tgccccctat cataaaagaa tttaaacagg 3492061 cttttcccca agtaaagctc atattcaaac catatatctc caatgaacaa gcgaaagaac 3492121 agctcttaca gggccagctt gatatcacct tcatcttgga tgtaaaccgg atggaagacg 3492181 cactgcacgt tgaatctttg attcaggatg agatcaaaat ggtggctgct aatgaccatc 3492241 cttttcctgc ggatttacca gtaacattga aggatcttca aaacgaaact cttctgctga 3492301 cagaggacgg ctgctcgtac cgcacgctct ttgagaacaa tttgcatgac tccggtatct 3492361 atcctaacaa attggaattc gtcagcatag aagccatcaa acaatgcgtg atggccggac 3492421 ttgggattgg aatcttgcct gaaatgacag taaaagatga tattgcagca ggccggatga 3492481 aagaactcaa ttggcagagc gattgccccg ttttcactca attagcatgg cataaggaca 3492541 agtggatgtc tgcgccatta aaggctttta tcgatttgac acggaaaaca ttcaaataaa 3492601 acctctccac aaggacgaca aggtttttga gaccagggca cacacataca aaaaaaacac 3492661 ttgatgactt agagccccaa gtgttacacg tgatttttct gataaaacgt tcgcaaaaca 3492721 tgcgtctcaa ggtcagccag gcggacaggg atcggcagcc tgctttcttg attgatcaag 3492781 ctcatcgtga tctgatagct gctgtctaaa tcaatataat taccgcaaga caagaaaata 3492841 ggcttcacgt cccgccgcgt tcgcagcgcc cgtccatata cctcgccgtc aatgataata 3492901 tcggtgtatg cgcctacttc aatttcaggc gtcacgaaat cgcagccttt gattttgaga 3492961 taggttttcg ctatcccaat cgtcggcttg cccagaaaaa aagccgcatg ggtggcaacg 3493021 cccatatgat tgtaatgcag atatccgttg ccatcaaaca agaagacatc cggctccgtc 3493081 tccagctttt tcgccgcctc gatgatcaag ggcagctcgc gaaacgcaag aaaaccggaa 3493141 acatacggca cgctgattct ccccatgctg tgcacttttt caatgacttc ttttgtatca 3493201 gcgtcaatta cgataataca gcacactccg tatggttctc catcctgctc ccaataggcc 3493261 aggtcgacgc ctgcgcaggt gttgatggag tctggatgga tcgtggggga taggttgata 3493321 cgatttttaa ggttaaattg cacttgtaaa aagtcttgtt cctttttcat atcaaattta 3493381 tgcacatcaa ataccttcat aacgattgct cactctcgac ctaaattaat gtgagtctct 3493441 cttctcgatt ctagtatttc aaaatgagga ctatctgtat ctatctcgta cttatttaat 3493501 agattgcctt cttcatccca attcttttca gaaattagta tggaatgctc atactgttgc 3493561 tcactttttt tcctgccatt ttcaaaccaa attatgctta taccgtgcaa ttgcccatat 3493621 cggtattctt tttcactttt tttattcccg ttttcataaa attcacatgt taaaccatgg 3493681 gccagaccat tcttatattt agtaaaatag atgatttgac catttggata taattcgtaa 3493741 gccagccctg taaacggctg gccattttcg tcttcaggat tatctaaaat ctcatcactt 3493801 accgaagaga accataaatc ctcaaagtcc actccctttt cttttatact cttcatatca 3493861 tattcatttt ccatacttta aagcctccgg tatataattt gtattttgag ttatatattc 3493921 acaatgtgga catctaggca ttgggacacc ttctggcatc tttttattta ttttcctagc 3493981 acttactaca tataccatta aatcttttaa atccgcatca ggtctttgaa gtaacgcttc 3494041 atttagagca ttaacttcgg catgagaacc cgcccctgac gtctttatat aaccttcttt 3494101 aagttctgta ggcatattta caattctatc atgaataagt ggatgtagta ccttaggtgg 3494161 cttcccatct atattgttta ttccaaaata ataattgcct gtttttttgt ccaatacacc 3494221 agctaccgca gggcctcttt gttttttagt tagaccagaa gatttaattc tactaagttc 3494281 gtttagtact tctgccctta gatttattcg atggtgaaga tcttctttag acaatacacc 3494341 atgcttattt cttaaatatt gaagcctagt ttgtttttct tcagtagtct tagcaatatt 3494401 gctaataagg ctttcattac tcactttatt gacatatgga gcattttttt ggtacaaccg 3494461 atcaaagtag tgtgccaatc ctgctccacc aataatagta atagcttcca gcgccccttg 3494521 cttccgcttc tcctcagaca ctttgtttcc gaacatatcc cggcctgtga cagcttctga 3494581 gaatccgttt gacgcaacaa ggccgtatgc gcccatttct gtcattttga gaatgtctaa 3494641 ggatttgcct gttttgtagg cgtctaatgc gtgttcagca gcgatagctg cttttccggt 3494701 tttgtagatg gcttttccgc ctttgaaggc ccggcctgcc cagccgacga ctggtatgaa 3494761 tccggcagcg gccatagctc ctgctgtcac acgctccgcg gtggagagtt tttctccggt 3494821 aaccggatca acgccttcgg ttgctctttt ataatcataa tagccagtga cttctccagt 3494881 aaagttgcaa actccatccc atgttttttc gtaccacggt ttgtttgctt cttcctcggc 3494941 tttttcctgg agccgtcttg cttctgcttg ctgggttttt gcatcgatat aggttgttcc 3495001 ttgattttct acttcaatga cgcttttgta gacttcattg ctgtggaagg cttttttgtc 3495061 atagtacata ggggatgcgc tcttcccatt gctggtggcc tgcatgagaa cagaatattt 3495121 ggtgagcact gcgttgtcca gagattctaa attttgatat tcagtggtca gggattcatc 3495181 aagcttatcg acagctgtga ttgtatcacg tctgattttt tgggcatcgc ccatcttatc 3495241 tgcatagtcg tcaagcgtgt acatgtcgag atcaataata tcgctgatgc ctgacaaaat 3495301 agaatcgatt tcttctttat gagcggagac aatctctgag gctttcaggt ctccattggg 3495361 cagctcatga tccaaaaaag aagtttccac atatgaatca ttcagttctt gatctttaat 3495421 atctcctgaa atgccgttta aaaacgcaat ttgagcagag acaagcgtca gccagctgtc 3495481 tacgatttct gcctgtccct gaaaaaaatc tttaatattg tccgcgccat ttcctttaaa 3495541 attatcgcct aaatcggcaa ctccctgaaa cgcttttttc agcgtattca gctgctcttc 3495601 aagcgtctca tattgctttt ttctgctctt cgcttcttcg attaaagatt ttgattcaaa 3495661 tactttactc atcgcactgc cctttctgtt ctattttacc gctatcgcct cgtcctgctc 3495721 tttgagtgaa tctacgttat cctttgtatc ctcgatattt ttctgtaccg cttttttgta 3495781 atctccgagc atggttttga tgttctcctc acgctcatgg tattttttcg tataatcgag 3495841 gctgtttttt ccgttggatc ctgcggcgcc gattgatacg tcagcaagcg catctttgac 3495901 agaatctaat gttttgatga ctgtgtcgta cttcagctta atttctgaca taaaaaaaga 3495961 tcaccaccat tttagtttac taattgtatt tccgacttct tccgcgaact cttctccctt 3496021 tttaagaaga tctgctgcac catttgctat gaacaattcc gatgcatatt tagctttatc 3496081 ccattcaaga tcaaaaattt tcccgttaat cgaagccata tactcgttat atttatcatt 3496141 cacaatctta gatgcttccg atttcgcctc ttctcttccc ttgtcgaaat catcggcttt 3496201 tgttcccgtc caatgcttgc ccaattccgg tttcacaatt tctttgattt cagtgattgc 3496261 ctcttcttgc agtgtgtcta tgtccttttt tgcttttttc agcttttcga tcttgtcttc 3496321 cacgtctgaa atttttccgt tgagcgaact tttgatatcc gctagcatac tttcataacc 3496381 catctgaatc acctcttaat actcaaaaag tcgtatggag gggctgatga agatagactt 3496441 ttccatactt tatttccata tattatattt taaaatagcc agaaggcggc ttaaataggg 3496501 taaatggctt aatttaggca tataacgctc ttgaaatgta ggtatttgat cttgtttttg 3496561 ttcgttatac agctaataaa agcgttttat aaaatgaaat cacctaatgt catagttata 3496621 aaggcacttg aaagaggcag atgttgttga tctgcctctt tcggcgctga gcttattgtt 3496681 catgtttatg ttcttcatct ggtcggccat gtctgatttt gtcatttggc ttctattatt 3496741 ccccccttct gaccctttgg atcaaaagct tgtattagct gcagtcccag ttgtacagaa 3496801 cgtttgaaaa gtcttttttc cttagatctt caggtgtgat gaaaaaattg gcgatgccga 3496861 cgtctcccca cattgaatcg atatcatcgt ctgaatcaat ttgtaacagc atgatggtgt 3496921 gttctttata tgcgtattcc cggggatcat gctgggtaaa agaagcgtat ccgccaattt 3496981 tatggccaaa tccgttttca gccagttcat tataaatgtc ttcttcatcc tcgccgaact 3497041 gaccaaagaa ctccattgtt tccatgcccg tatactgctc aaattgaaaa tctgtaggca 3497101 gcacccattc cgaagatttc acaggctcga ctgccgcttc tgataaaatc ggaaaatcac 3497161 attcgcctgt gccaataaat gaaaaatcag aaacaagctc gtcatcgttt tctacgatat 3497221 tttcaaaata gatcactctg aaattctttt gttcacatcg atcgtcaaaa ttcaatccat 3497281 agacgtcatc atgaacagaa atgtagaact gcaggatacc tgaagaaggg tagccgtcaa 3497341 gctggggaat gtgcgagaaa ttaatctgcg ccagaagttt catcggctgt ccattttcgt 3497401 cagtcggata tgtttcatgc ttggggaaat agggatcacc ggcaattttg ctgtcatatc 3497461 gtcctgtttt cccctttctc acattcagtt tcacgtattc tttcgctgat ttctccagca 3497521 agtcgcggta cggtctcatt ttttcgggca gatgattcat cagattctct ccttttccgg 3497581 catctccaag gttttatttt ctggttttct tctaatgttt ttcaaacgaa tgtttaaaga 3497641 agccctactt ctgcataatt ttccaaacaa tagttaaata gtagcaaatg tattcagcac 3497701 cccgcaatag atgaaaaaaa gactggtgcg caaccagcct ttctttttca tctattgaat 3497761 tgcacctgac ggaacaaccg ccttccgtcc gacagaataa tactccactc ctgcagccaa 3497821 agcctcatcc aatgtgtagc agtttctgcc gtcaaatatg agcggcgttt ccatcaaatc 3497881 ctgataagcc gctaacggga attgtttaat gtcagcccag tcggttaaaa tcatgacggc 3497941 gtcagaccct ttgacagctt cctcgatcgt ctctttatat tcaacagctt gcgggagaac 3498001 atgctttgca tggctaactg caatgggatc gtaggctctg atacgggcgt cgagcgcagc 3498061 gagacggtct gcaataacaa ttgacggcgc ttctctcata tcgtcggtat tcggtttaaa 3498121 tgacaggcct aaaagggcaa tcgtttttcc cgtcacccca ccgagcctgt tcagcgcttt 3498181 atcaaccagc atcgcctgct gattgttgtt gactttgata acggatttca gcagttcaaa 3498241 atcatgctcg acattgccgg caatttgcac gagggcgttt gtgtcctttg gaaaacaaga 3498301 gccgccgtag cctatgcccg cttttaaaaa ctggctcccg atccgcttat cctgtcccat 3498361 cccgtatgcg actgcttcaa tatcggcgcc gaccttttca catatattcg aaatttcgtt 3498421 tataaaactg atcttagtgg ccagaaaagc atttgaggca tatttgatca tctcggcgct 3498481 tctgatatcc gtttggtaaa tcgggatttg aaacggacgg aagagctcct ccagcgtatt 3498541 tgctgttttc tcatcggccg tcccgatcac gatcctgtca ccatgaaagg tatcatagat 3498601 cgccgacccc tcacgcaaaa attccggatt ggatgcgacc gaaatactga caggctccgc 3498661 tagatgttca gtaatcagtc cattaatcaa atcgtttgtc ccaacgggca ctgtgctttt 3498721 cgttaccacg actgtatctc gtttgacatg ctttgcgatg cgtttggccg catctgtaat 3498781 ttgctccaga ttggcgtgcc cgtcgctttt ctgcggtgtg ccgaccgcta taaaaatgat 3498841 gtctgcctgt gccaagcctt tctcatagct cgtttcaaag ttcagccgtc catcagctgt 3498901 attttttctc atcagctctt caagacctgg ttcaaatatg ggggaaatgc cctttctcat 3498961 ttcatcaatc ttgtgagcgt caatatcaat gcaggttaca tgatgtccaa tctcagaaag 3499021 agaaacacct gtcacaagac cgacatagcc tgttccgatg actgttatat tcattgtttc 3499081 cctccaacag ttaaattgct gctttgcagc ttccgtaata tcgtatgaga acatcctatc 3499141 atgaatgcga atgatctccc gcatagcctg tcgggtacag cctgtacaga tttctgaaat 3499201 gtgattcaac catacaatac actattatat cgctctcaaa aagaaagtgg tgaaatgaga 3499261 atcggctgtt aaaaaaaacc aaacaatttt cttcttttga ccggctgcgg aggctgtctg 3499321 aagatggtct gattccgcag gagaagctct gcattttccg tcagcatata aggaagttcc 3499381 gagccgaatt ctttctctag aacataaaga gcctcttgag tgtgaaaatt tctcgttttc 3499441 acattatggg catctgaggc tacgaaatgg atcaaattgg cttcaaccag ccggagagaa 3499501 aatgctttca gctgcttgcc gaagatcccc gcaagacttc ctgaagtaat ctgagatgct 3499561 gctccttttt ccacaagatg atacagcaag gacgggtttt cgcgaatttc cctgttgcgt 3499621 tcaggatggg cgataaccgg aatatatcct ttcagctgca aatcataaaa aagctgctcc 3499681 gcatatcggg gaacgtgatc aaacggaaac tcaatcaaga tgtattttgt atcattcagc 3499741 gaaagcagct gacgtttggc aaggtcttgt tccacctcgc cgtagattct gatttcctgt 3499801 cccggaagca catgtaaagg aatgtcttct ttgattaaac gtttgtttaa ctgatctgct 3499861 gcttctctga ctgcggctgg ctcgttttta tacacaccgt tgttatgatg aggtgtcgca 3499921 atgatcgtcc ggattccctg acgaacagct gctcttgcca tttctatgct gtcggccgaa 3499981 tcacctgccc cgtcatccat tgcgggaaga atgtgacagt gaatatcgat catgtcctag 3500041 cccccttttt tcgcaaaaat aaataacggg cacgatgcac gttatttatt tttgcatgaa 3500101 attgtccttg gttccgtaat atccgtattc agagtgcttc gaaagctttt tgccgttcat 3500161 aatcgcccca aggagcttgc ttttgcacgt tgcaagcgcc tctttcgctt ttgcggcttg 3500221 ttctttttct gttttcccgc ttgaaataac cagaacagaa ccgtctgcca cgttgcctaa 3500281 aatctgtgca tctgctacgg caagaatagg cggcgtatca aaaatgacca tatcatatgc 3500341 cgcacacgct tcgtatgcaa gctccttcat ccacttcgag gagagaagct cggccgggtt 3500401 tggcgggatc gggccgctcg tcagcacgtc aagatgtttt tcattcgatg cttgtacagc 3500461 ctgctccata gagcttttct ttaataaaac agatgttaag ccaaccgtat tttcaagaaa 3500521 aaaagccgta tgtactgttg gttttcgcaa atcagcatca atcaggagca ctttttttcc 3500581 ctgttgggcg aatacgacag ccaggttggc ggccgttgtt gattttcctt cccccggaca 3500641 agccgatgta atcatgactg atttcatttg ccggtccact gaagcaaatt ctatattcgt 3500701 gcgaatcgtc cgatattgtt cagagttcaa ggatttcggc tctgtcattg caatgacatt 3500761 tctctgcatc cgcgagcctc tgttttttct aagcgccaaa atgtccactc cccgtttttt 3500821 cagattggaa accctgtaag gtctttgctg ttttctgctc attcgcaatg gtggaaactg 3500881 tccctaaaac aggtatgtcc agcaaggatt cgagctgctc ttccgatttg atcgtattat 3500941 ccaaatgctc aagcaggaag gccagtccga tgcttcccgc caatccggcc gcaaacgcga 3501001 tggcaatgtt tagtagcggc tttggcgata caggggacgg gtgttctgaa acctcggctt 3501061 ttgacagaat gctgacattg tcaacattca taatggatgt gattttgtct tgaaaaacag 3501121 atgctatagt attggcaata tgagccgctg tttccgcgtt ttcatccctg actgatatgt 3501181 tgaccacttg ggagtcctgt tcgctggata cggtaatttt gtcattcagt tcttgggatg 3501241 tcatcgacag gcccatttct ttaatgactt catctaagat ggcagggctc ttaatgatga 3501301 cattgtacgt attgattaac tgaagattgg tttggacatc gttaaattgg acttcttttc 3501361 gttcattttt cgattggttg accagaatct gagttgaatt ttcatagatg ggtgtaagtg 3501421 cgaagaaact aatgagtccg ccggcagcag tggcagccgc ggttacaatc ataatcaaaa 3501481 gtatgcgttt tgttaacgtt gataatatct cttttaagct tgtagattct cccatgatac 3501541 ctccaaatct cttataacat ccttttccat ctacgattat acaacgttga aaccgcattt 3501601 ctccagcttt tcacgtgaca taattcgaca tttttttaca atgcgttatg ttagtacttt 3501661 ttatgtaagc gctatattta ctgtgttgac agtgctgtct cattttctct tattcgggca 3501721 gtcacgttct ctcgcataaa aaaatcccgc taaaggcgtg cgggattttt atgttgcata 3501781 tccattttta atatgagaaa tcaaattttc aagcatttcc ttcgtcgtca tctcagatga 3501841 ctgctcacca atttcatgtg catgcatcaa aattttcaga aattcttctt gattcaattt 3501901 cttttcactc atcttttttt tcctttcagc ttccattaag ttgaaaacac gattattata 3501961 tgatgctggt tatcaatttg caatctctaa tacatcattc gacacatcct attttttatg 3502021 tcctttttta ggaaaaactt tttaaggccg atgtgttgcg atataataga gaaattggat 3502081 ctttttatta cgtgactcgg ttaggagcga taatcatgct tcagaatatg atttccaaag 3502141 acgatgtgct ggcatctgct gaacagttaa aagaacttct tccttacaat gaggaaaatg 3502201 ttcagctgat caaaaaagcc cttattttat atcggcagga ttcagtctat cgtttacaag 3502261 cagtgagtcc gacggaagtt acggcttacg tgcaggatgt tgtgcctgtg cgggtcacat 3502321 tgaacttgtt tgtcatagtc aaaagcggct gttcatgtcc gtccggaaga atctgccgcc 3502381 atatgctggc tgtgttttta tatgtatatg caatgttcga gcgagtgggt acttttacag 3502441 agtattggct ggagagggaa aagcttgagg aaagcaaaga gctcgtccgc cgccagtttc 3502501 aggaaaaggt gctgcctaat gaagaatcac tttcaagctg gcttgctttt tttgattcag 3502561 agttttctct ctggcaggca cgtacgccag aaggcagcca aaacatgcag ggcctctatt 3502621 acggctacct gtccgcatta aaaaaacatg cgccgaacaa gccggagctg aaaagcctgt 3502681 atcagattca ttccgcgatt gcggtttggc ttcgcatgtt cacattgatt gaagcgggca 3502741 agctaaaccc cgaacaagat ttttattccc tcaatccgta cgttgaacag ctgatggata 3502801 caatctacag ctctattgat aaattaaaaa cgtacgcgct gtcttttgcg cttgatccgt 3502861 ttttggataa aacaccggat gttatccggc atttgctgtt gaaagaagaa attttccaat 3502921 atgaacgcat ccgcgtcttc ggtgaaattt ggagtgcgct gctgtcgcgg ccaaaatggg 3502981 tggcacgcga acaggagata ttgaaaaaag aagcaggacg gcgtttttct cccgaattgc 3503041 aattcgggcg cctgcatttg gaattcctgc aaaaaaatga tgacgttatt tttgaggaag 3503101 cggatcaatt cccgccggaa gcgctccctt atacattcca atggctgagt gaaatgactg 3503161 ccaagaagga ctggaaacgg cttaaaacat ggtaccagca aattgaacca attgcgatgg 3503221 gttatacgaa gctggataag ccgtttaaag agattcgcga tgtgatcggc gagctgttcc 3503281 ttctgttgaa tgcctatgtg cagcaaacca atgatcaagc gctgtttgag cgctttgccg 3503341 cgggctgtct gccgtatacg ttcacagaat acagccatca tttatatgaa aaaaaacgct 3503401 atgccgagtg gattgaaatt catagccttg tcggcttttc catcaatgaa atggataaaa 3503461 tgatgctcaa ggaaattgca gcgagcgacc ctgaggcgct tataccggct taccatagag 3503521 aagtggcttt tttcattgat cagaagaacc gtagctcgta caaggaagcc gcccggtatt 3503581 tgaaaaaatt gcgcaccctg tacaaaaaag cgaaaaagca gaaggtgtgg gagcggtata 3503641 ttcagctgct gagctcgcat tacaagcgcc tgcgtgcgct tcaagaagaa ctgcagaaag 3503701 gaaagttgat tgatggcgag tcttaaagaa attctcatcc acgtcgaaca aatggaagat 3503761 gggtcattta cgctctcagc ctttgatgag aatgagcagc ctcttcccta cagccatatg 3503821 aaaaagcatt tgttccaatg gcatgaatcc tcattttacg gaacctttct agaggatgtc 3503881 agcttcatcg ggacgactgc tgtccttcta tctccatgga tgactgtaga gcttctcggc 3503941 aaaaactcgt tcaactcatt cagctccgtg cagcttacag aagaaacgga gccgctgatc 3504001 gaggcggcat cgaccatcta tgaatttatc gcggacggcg attttatgcc tgactatgac 3504061 gcatggacaa acggtgtttt tcgctggaag gaccgcgata atatactgga aggctttact 3504121 gcggaatggt tttccgctgc cgtacaggat tacatccagt acgacgatga cctgcgggag 3504181 aaatgggaac atatcaagga aaaatcgcct gcggttacga cattccgtgg ccattttctt 3504241 gatgaagagg attttctgga aggcattggc tggattgacg atcaatctcc atttactgtc 3504301 ggcttgcgct taaatgaacc ggactttgac ggagacgaat ggaagatcga gatgttttta 3504361 cgcgataaaa agagcggtgc tgtagaattc tttgacggac tgaagagcct caaaaaatcg 3504421 tggcaggcgt acagcgataa aatcgcgcgt gagcaggacc gctttcacag aacggttccg 3504481 tggctgtcgt ttgattccgg gacaacgctg atctcggagg aagaagcctg gatcttcctg 3504541 tcagaagcaa gtgagacgct tgtcgatatg ggggtagaaa tcctcctgcc gtcctggtgg 3504601 cagattgtca gagacagcaa catgatgctg aaagcaaagg tgtcttcctc cccgcgcggc 3504661 gagtcatttg tcggcatgaa tgcactgctt gatttcaact ggcggtttgc gacaaatgga 3504721 attgaactga ctgaggctga atttaatgag cttgtcgcca gcaacaggcg ccttgttaat 3504781 atccgcgggc aatgggttaa aatcgatccg cagtttatca aacagatgaa acgcctgatg 3504841 gaaaaagcag aatcagaggg actccacatg tctgatattc tggcgcggga gctaatggat 3504901 cagcaggatg gcggacttga ggattcggac ctgattgata catctgcttt tgccggcatt 3504961 cagtttgatc tgtctaaaca gctcaggtca ctgattcgaa agctcactgc cgcggaaaac 3505021 ctgccggagc acaaagtcag tccttctttc aaaggaacgc tccgccctta tcagaaatac 3505081 ggcatgaact ggctgctgtt tctgcgggaa agcggttttg gcgcctgtct ggctgacgat 3505141 atggggcttg ggaaaacgat tcaaatgatc gcctatttcc ttcacgtgaa ggaaagcggc 3505201 cgacaaaaaa cgcctcattt gattattgcg ccgacatccg tacttggcaa ctggcagcgg 3505261 gagcttcaaa cctttgcccc tgatctgtct gtcgcgctcc attatgggcc gcgccggcca 3505321 aagggtgatg atttcgccgc gcattatgaa aacgcagacg tggtgctcac ttcatacggt 3505381 ctgtcacatg ccgatactga agagctttct tctgtgacat ggaacacgat ctgccttgat 3505441 gaagcgcaaa atattaaaaa cgcgcatacg aagcaatcac gcgcaatcag gaagctgaag 3505501 gggcttcacc atatcgcgct gagcggcacg ccgatggaaa accgactgac tgagctgtgg 3505561 tctatttttg acttcatgaa taaaggctac ctcggcagtt tgaccggctt ccataaacgc 3505621 tatgtgctgc cgatcgaaaa agaccgggac gaaaagagaa tcggacagct tcagcaatta 3505681 atccggccat tccttctccg ccggacgaaa cgggatgaag aggtcgcgct taatcttcct 3505741 gagaagctgg aagaaaaaga atttatccct ctgtcagccg agcaggcatc cctttatgag 3505801 cagctcgtca aagacacttt tgaccatatg acatccctga ccggcatgca gcgaaaagcg 3505861 ctgatcctca gcatgcttgg acggctcaag caaatatgcg atcatcccgc gctttattta 3505921 aaggaagagc aaaccgagct gctggccggc agatcagtca agctcgaaaa attgctggaa 3505981 ctgatgacag cgatccgcgc ccaaaacgaa agctgcctga ttttcacgca atacattcag 3506041 atggggaaca tgatgaagcg gctgcttgaa aaaacgttcg gggaacctgt gcaattttta 3506101 aatgggagtc tctccaagca agagcgggat acactcgttg agaaatttca aaggaaagaa 3506161 tatccgacac tgattctttc actcaaagct ggaggcaccg gacttaattt gaccgccgcc 3506221 aatcacgtca tccattatga cagatggtgg aacccggcgg ttgaaaatca agcgactgac 3506281 cgtgcatacc gcataggcca ggagcgcttt gtccacgttc ataaaatgat tacgacagga 3506341 acaatcgaag aaaaaattga tgtcatgctt gaatccaagc aaaccctgaa cgatcaaatt 3506401 atccaaagtg aaaactggat taccgagctt tccacacagg agctcgaaga attgtttaca 3506461 ttaagcgcta cagcgcaata atcatgacta aaaaagctgg ctctaaaaga gccagctttt 3506521 ttccgttcat agccgtcacg ccgaatttcc aaaaaatccg ttacgccggt tatcaacagg 3506581 gtgcgctttt gtggcagcac atatacttac aacaaatgtt tcatcatatg tgcgacaccg 3506641 tgttcgtcat tggttaaggt gacagcatcg gctatcgatt tgatgtcttc ccgggcattg 3506701 cccatcgcta caccttttcc cgcagcctcc agcatcgatt tgtcatttaa actgtcacct 3506761 acagcagcag tttcctcgag cggaatattc agctgttttg caagcctctt cagcgcctgc 3506821 cccttggaag ctttgcggga agaaagctca aagttgtgct cagccgaact gacaagcgtc 3506881 aaatcttcgg catgctcata tcttttccag cctgcctcaa gcttttcttt gaagaaagaa 3506941 aagccgagaa tattgtaaaa atcgattggc tcatcggctt caaacagctc ttgaaaggag 3507001 ttaatgtaag caaagcccga ttggctgtat tgcacctcgg ccgcctgctt aaggacagaa 3507061 agatccgctt ccggatttgc gcttctgaat ctgtcgagct caacatcaag aagttctctg 3507121 ccgttttgcg gcgtataaat cgctgaacct gtgaatacct cataataata gttttccgac 3507181 tcaagccatg agagaatgtc atacgcccgt ttcttatcaa tcgtttcgtg atgataaagc 3507241 ctgccctcgg gatcgtgaat gacggcgccg tttgcactga tgacccatgt tttgatcccc 3507301 agcggttcaa agattgacat gacgtcaaaa tgagcgcgcc cagttgacac caccacttca 3507361 atgccgtccc gctgcgcctg ccgcagtgcg ttttcatttt ccaagcttac ctgatgcttg 3507421 ctgttgagta aggttccatc taagtcaatc gcaattaatt tcacgtttgt cagtcctttc 3507481 cttcatcctg ctctgtcacg agaagctcaa cgccgtttcg gtcaagcaag tcacaaaatg 3507541 cctgattcgg cagcctgtct gtaatcaaga ggtcgatttc attcagctcc gcatactgat 3507601 aaaaactggt gctgcccagc ttagaatggt ctgcaagcgc aattacctgc tttgcctgct 3507661 gtatcatttt ccgcttcacc atgccatcct cttcatgcgc aattgtaatg ccatgttcgg 3507721 aaatgccgac cacaccaatc agcgctttat caacatggta gcttgagagc ttttcaatca 3507781 cagaggaccc gtacagaaag cggtgctcct tttccagctt gcctcccagc agataaattt 3507841 caattccctc tttatcggac agcacatccg caagattaat cgaattggtg attacggtac 3507901 aatcaaccgc attcaaatgc tttgcacatg cctgaacagt tgtagaggcg tctaaaatca 3507961 cccggtctcc atcatgaata agcgatgctg caagcctgcc gatcttattt ttttcctcag 3508021 acactgtttt caggcggccg gaatagcttt gaattttctg atgcacagtc ggtaaaatgg 3508081 cgccgcctct tgtgcggatg atggcattct gttcctcaag tttcacaaga tctcgtcgcg 3508141 ctgtatccct tgacacttgc aggagcgtac agatctgctc cgttgtaatt cggttatgct 3508201 gttttaaaaa atccaaaatc gctactaatc tttcttcttg gtacacgccc tcattccttt 3508261 tctcagcaat catttataag taattataag tttttatttg attttattca acattaataa 3508321 gtgattttaa gtaaaaatgc gtcgagagaa ccaatttttc ctaagtaggc aaaaagaaag 3508381 aaccagtctg gtcgactggt caattttgag gggatgatgc gaagatccgg ataatagtga 3508441 atggatagat aacgggagga gcaggggtgt caatcagcag ctttttcccg gggtttaggg 3508501 tccataaaac gaacagtgtc agccaacact tctgttacat acacgttaac gccttcctcg 3508561 ttttcatagc ttcttgtctg aatccgtccg cttacgccga cgagagaacc tttttggcaa 3508621 tacaacgccg tgttttcagc tgtttttctc caaagtgtgc aattgacgta atcagcttcg 3508681 atttcacctg aagcattctt gaagctgcgg ttcaccgcga gcgtaacatg tgcaactgcc 3508741 gcaccggcgg aagtgtagcg aagatcagga tcttttgtaa gacgtccgac aagcatgacc 3508801 tgattgaaca tgcgattcct cctctccttg cggttgtatg tattgtaaat gatgcaacaa 3508861 gaaaagaaaa acgcttaaaa atggctttca gcctctgttt ttatctttcg ttttcatttt 3508921 tccttcagct aaaaacatct tttgcttttt tcctttgaag aaatatgtac tttttaaaaa 3508981 acggaaaaag atttgctttg tcagccagtt ttgcgtattc atgcgcacat aggaagagcc 3509041 atcccacgca aaccactgaa agctcaattt tttttccggc attgacagct tgattttata 3509101 ctgctccatg ccatcttgtg tttcgtataa aaaacttatt cttccttttt tgttcagatg 3509161 aacctcaaac acttctttac ggcttaacat atatgttact tccttttgaa tcaaatgact 3509221 ttcagaagga acgccgtcaa tataaatttc ttttaaacga aattgattca taccacatct 3509281 ctccgtaatc catagtcagt tacagtataa tgaaaaaata gaaattatta aatgtttcgc 3509341 tcatacaaaa ttctttagcc ccaacattgc aggatttttt cctcgaaaac gtttatgtta 3509401 taatggaagg caagaaaact ttggaagtaa tcggggtgag aagaaatgaa aacctttaaa 3509461 ctggttgacc tgaatgtgga acgagtggac aaggaagaac aatcaattga acagtttccc 3509521 cttattgacg gactgattat aaataaagaa gacggtgaaa atcactggct gattgaggcg 3509581 cttgtacaga aagaacatct gtcttttttt gaacagcttc aaaacagcca atctgaagcc 3509641 aaagtatttg taacgatcac gaaaaaaagc aatcgccccg cccagctgac agcagcagtg 3509701 aaaaatatcg tcaagctgga agaaagcatt caggttttac tctacggaca aatggtcaca 3509761 agaaaacagc agggcactga aaccattctc gagtcccttg taaaagaggg ctatacagga 3509821 acaaaactca ttgaggcatt taagcaaaaa ttataaatat gagggggcat gttccccaaa 3509881 acagactcag aaccgaagag catcacaata gacatttaga atagatatgt tctgcatgaa 3509941 aaaagctgcc gttttgaacg gcagcttttc tcttcgtgct ttcactcttg catatttaat 3510001 ttgtatggcc aaaagaatca accaattccc ctttcacaac gaggcgccct tcggttttga 3510061 ccgccttgtc acatgtgatt aacgtaatct cctttttgtt tgtctcctca actacatctg 3510121 catccatttc cgatatgatg tctttcgatg ttacagaata gatataatcc tttttaaaat 3510181 ccgtgatgac aatttgggca cctgttttta tgttttccag aggtccgaac agaagattct 3510241 tttgcttcaa atgatggccc gccaacggat aatttccctc acccattttt tgatcccggc 3510301 gcattgttgc cgcccctatc aaaagatttt cattggttgt gccttttacg atcggaagct 3510361 ccagatcgac acttttaatt gttatccgcc gccttgattg tgaagtaaaa ataagtatat 3510421 ttcacgtgct ttcgacgttc tccacttgac tggaatgctt taatggcgat cccggcatct 3510481 gtagcttcag gctttccttc agaggaatca gaaatctcaa actctatttt ctcagtgttc 3510541 agcacataac cggctggcgc tttcgtttca acaaaagcgt attgtcccgg tgcaaggcct 3510601 gaagctgtga cttgatgatg ccggatatga ctggtttcga agtctgtatg aaaattcgcg 3510661 aacgattcag catggttgat cttccggttc tgatcattac agctgccatt atcggccatg 3510721 acaaatacaa ggcttttcat gccggagcga atgacatttt gcaaaaaccc tatcattact 3510781 ctgaatttat ggcgcgtatt caaaacctga taatgatgaa acatacagca aatcaagcca 3510841 caagaatgga aatggcgttt ctccagtcgc aaatcaagcc tcattttctt tataatgtat 3510901 taaacacgat tatttctctc actcatttgg atattgaaaa ggcccgggag gtaacagagg 3510961 aatttaccaa ctatttaaga atgagttttg actttcaaaa tacatcagcc atcagttcct 3511021 tcagacatga gctttcgatt atcaattcct atctttctat agaaaagacg cgattcagta 3511081 atcggcttga ggttcttttc gatatagatg aagacattga ctttatcctt ccgcctttaa 3511141 tgattcagcc cttggtggaa aatgccgttc ttcacggtgt cagcaagaaa agaggcggag 3511201 gatggatcaa actgacagct aaaaaacaaa gcaaaaatga gtatcacatc aaagtagagg 3511261 ataacggtcc cgggataact ccggaaaaac aaatagatct cttatcaacg gattttgatc 3511321 gcagcgtcgg attgaaaaat atcaatcagc ggctgaaaca tttttgcgga agcgagttga 3511381 tgatcagcag cactccggat gcaggcacct ctgtctcaat gctcattcat ctcgctgaaa 3511441 caacaggaag ccctaaagaa ctgaaggaca cagaacgaac ctaaacgaaa attgagataa 3511501 aaaaagacgc cgtttctaac ggcatctttt ttattccggc gactttgctt gctgcttcag 3511561 caggtctctg atttctttca gcagctcctc ctgcgcatcc accgcttcct ccgcagcctc 3511621 ttcttctgct tcttttttgc gccttaaccc attcaaagtc cgaatgacga taaaaatgga 3511681 gaacgatata attaagaagt tcacaatcgt ctgtataaag ctgccatatt tcactacagc 3511741 atcgccaaac gtaaacgaca ggcctgaaaa gtcaagccct cccagcagca aaccgaccaa 3511801 aggcataatg atatcattta ctagagatgt gacgatcttt ccgaaagcgc cgcctatcac 3511861 aacaccaatc gcaaggtcta cgatattccc ccgcatggca aaggctttaa attcattcca 3511921 catacaatca cctgcttttc tatatttgta aagaaaaaaa gacaaatgtg ccgctggcca 3511981 tctgcctttt ttcaattatt ctccgagggc aaaagtcagt tctacttcgc aaacgacttc 3512041 gccatcaact gtggcaacgc cttttccgcg cccgattgtg ccgcgggcac gaatgatttc 3512101 aacctcaagg tgaagctggt caccaggctt gacttgtttt ttaaagcggc agttatcaat 3512161 gcctgcaaaa aaagccagtc tgccgcggtt ttcttcttta atcaacatcg caacagctcc 3512221 gacttgagcg agtgcttcta cgattaatac gccgggcata accgggtact gaggaaaatg 3512281 tccgttaaag aactcttcat tagcggttac atttttatag ccttttgccc gtttgccctc 3512341 ttcaacttcc gtaatccgat ccacaagcaa aaacggataa cggtgaggaa taatttcttt 3512401 aatttgctga gtatcaagca ttgtcttgac atctccttca tctgcattag tatgtatagc 3512461 aatcatcaaa gatccaatct gtacatttga aaagtatatt atgaattaat ctctttttca 3512521 accgcgctaa aatgtaacca actgtcaatg agagccgtca aaagttatga tatgataatt 3512581 atagatttta ccaatagcaa agaggtagga aaatgatttc gaagtttatt gaaaaaagaa 3512641 tgctaaacat gttagacgag tggtattccg caatgagcaa acgcaaaatg aatcacgttt 3512701 gcacactgaa agagaaaatt gatcagcacc ttccaaagat caaaaagaac acaaaacttt 3512761 ggatgcgtta tcaattgttt caggcccgcc atcagctgct ttttgaaaac cagaacggac 3512821 tcgattcatt gttcgatggc ctatatggcc tggaagacaa aatggatgat gaattgaaat 3512881 attatctgta ttttttctct gggttatatg agatggtaaa aacagctccg aaacatgcag 3512941 tacatcattt taaaaaagct gaacagtacc tggccgccat tcacaatacg tttgaagccg 3513001 ctgatttata ttatcaaacc gccggcgcct attacttgat gaaatcaccg ccgctttccg 3513061 tccaatacgt caaaaaagca ttacacatct atttgcacca attcggctat atcaaaaagg 3513121 taatcacctg taaacttttg ctcgccgtga attatattga tcaagaacgc tatgaaaaag 3513181 ctgaacagct tttcaaagaa atcattaaga aaacccagca actacatgac gaaaacctgc 3513241 tatgccacgc ttattataac cttggctttt taaaagcgac cgagaaaaaa gaccaggaag 3513301 cgcttcttta ctttagaaaa gtattaaaga atcaagaatt tgaaatgaat tcaccagtct 3513361 catatcttca ttgtgtgtac gagtctgtca gagcgctttt taaaacaggg aacatcacag 3513421 aagctaaagc cgtccttcaa aaaggaaaag aattatctga aaaggtagac attcaaacca 3513481 tttatttaaa attaaaaacg cttgaagccc tctacacatc agccgaagac ccttatgagc 3513541 agctgctcga atatgtgctt gaattagaaa aaatcgaggc gtgggtggat ttagaagtgc 3513601 tgttagaaga tattacggaa tactacaaaa aaaaggacga tttcgaaaaa gccgcttttt 3513661 ttatcatgcg cggctgattg aaaaacgccc attttcttat tatctgactg aattgattaa 3513721 accgagcatt tgatctccca ttgtgatcgt tctgctgttc agctgatatg aacgctggga 3513781 cgtgatcaaa tctgtcattt gttctgaaat atcgacattg gacatctcaa gtgagccctg 3513841 ctgcatgccg atgttttgtc tattagcgcc gttcagctct tcaaaagctg ccgcattatc 3513901 aatagagaaa aggttattcc cttcggattt cagctcttga gggttattca cttggacaac 3513961 gccaagatta aaccgctgaa ccgcgtttcc gtcagatgcg gttaaggtgc cgttcttatt 3514021 aatggtgata ttcttcattg agctgtcgat gttcactgta ttgccgttct catcaagtac 3514081 gggataccca tttccagtga cgagctgcag ctggttggca ttcgcagcgg acggcgttac 3514141 atacagcgcc ccgtccctcg tatactggcg gtttccattt acatttacct gaagatactg 3514201 gtatggagac gtaaatgcga tatccagatc gcgatcggtc ttctgaatgc ttccttgatc 3514261 agagactagg cgtgaactca tcatcgctcc gacgccaagg cgcaagccgg gcggcgtttt 3514321 tcgggctttt gccacttcct cgtttttttc atcaacctga tcgaattgct gtctgacaag 3514381 ctcagaaaaa ttcgtatctt ttgccttata gccggttgtg ttgctgtttg aaaggttgct 3514441 gctgattgtg tcaatctgct gctgcagctg gtttaaggtt gttgatgccg ttagcattga 3514501 cctgagcata gttgatgtcc cccgtttttt tcttccgttt tcttaaattt ttccaatttc 3514561 atttgctgct ttatccatac ttttatcgta agcctgaata accttctgat tcgcctcaaa 3514621 cgatctgtac gcttcagtca tttctgtata ggcgcttgtc acatccacgt ttgaaagctc 3514681 tgagacgcct tgttttaatg aataggctac ctgattattt ccggctgcgc ttggcagatc 3514741 attaccgtcc gccgtgctgt acaaatcatt tccgtcccgt ttgagattgc ggacatcttc 3514801 cgccattctg acatcaatct ggccggctgt gcgtccgttc gttgtcacag taccgttttc 3514861 agacacagtg aaattctcat tatcaacagt gattggctgg cgatccgtcg ataaaatagg 3514921 gcgtccgttg atcgtcagct gattgttctc atttagtgaa aatgtgctgc tttttgaata 3514981 acggattcca tccgctgttt gaaccggata aaaaagagca gctttttcat tggtttccgc 3515041 actcatcgga acttgatttt cgatcaatgc aatgtctgta ggctggtctg tggacttcag 3515101 gcttccctgt gtaaagagag gcttgagctc ctgcatatat actccggtat tcacggaacc 3515161 gatttccgtc cttgatgtcc cggccggaga ttttgattct attctgctga gcagcatctc 3515221 agggaacgcg cgcatagagc cttgatcagc tttatatcct gatgtatttg cgttagcaat 3515281 attatttgaa agcatttccg ttcttcgctg ctgggcaatc attgcggatg ttgctgtata 3515341 taatcctttt aacaaatttc ccacctctaa aaatggcatt ttttccagtt gtcatatagg 3515401 aacgttcgtt ctataataaa aactcagtat tttatcctat tatcgtcatt taacatcttt 3515461 tcgtgaaggc tttttcataa aaaaacctca ttctttttca gaatgaggtt tgtgaaatca 3515521 gcttagtttg cgtttaggaa gcttgtccat attatcaagc atgacacctg tgccgatggc 3515581 tacgcaatcc ataggatttt cagcaacgag gaccggtacc ttcagctctt cagcaagcag 3515641 ctggtcaagg ccgtttaaga gcgcgcctcc gccggtaata ataacgccgc ggtcaataat 3515701 atcagcagaa agttcaggcg gtgttctttc gagcacttgt tttgcagcct gaacaataac 3515761 agcgacagat tcacgaaggg cttcttcaac ttctttactg tttactgtaa ttgttcttgg 3515821 aagaccggaa accatgtccc gtccgcgaat ggaaatttcc tcgtgacgtg cgtctgggaa 3515881 aacagttgcg actttaatct taatatcctc cgcagtacgt tcgccgatca gcagcttgta 3515941 ctcgcgtttg atataattta agatttccat gtcaaacttg tccccagcca ttttaataga 3516001 agaggaggtg acaatatcgc ccattgaaat aaccgcgata tccgtcgtcc cgcctccgat 3516061 gtctacaacc atgttaccgc ttggctggaa tatttccata cccgcgccga tagcggcaac 3516121 tttaggttct tcttcaaggt acacatgttt cccgccgctt ttttctgcag cttctttaat 3516181 tgctttttgc tcaacggatg taatattcgt cgggcagcaa atgagcatgc gcggctttga 3516241 gaacaggcct tttacattca gcttgttaat aaaatgtttc agcattgctt ctgttacttc 3516301 aaagtcagca ataactccgt ctttcagcgg gcgaatcgca acaatattcc caggtgtacg 3516361 tccaaccatt cgtcttgcct cttcgccaac cgccagcact ttgccgctgt ttttatcaag 3516421 tgcaacaacg gaaggttcat tcagaacaat tcctttacct ttaacatgga tcagtacatt 3516481 tgcagtaccg aggtcaatac caatatccct tgcaaacatc tatttatatc ctccttgaaa 3516541 atctgtttca cagtaaatat ccacattgtg ccctaattat atatattatc ataaaatata 3516601 gaaaaaaagt tggaagcaca ataagttctt tacaaatttt tgcggatgtt ttatgaacga 3516661 tttcaagaag gcaatgccag gtgattacga ttgctgaaca ggctctcctt cgagaatttc 3516721 atctttttta tatttgagct ttgtcgcttc tcctcctctt aaatgcctga tggatttatg 3516781 ataatcgagt atttctttca cttcgtttgc caagtcgggg ttaatttcag gcagacgctc 3516841 tgttaaatcc ttgtgtactg tacttttgga aacaccaaat tccttcgcaa tgacacgaac 3516901 ggttttcttt gtctccacga tgtacttccc tatcttgatt gttcgctctt tgatgtaatc 3516961 gtgcacacca ctcgacctcc ctaaaatgga tgtgagaagt gtgaaatgag atccgtattc 3517021 tgtaaagagt cgttcattat gccgcttctt cgttgtatgg ttttaaaagt aagtttgtga 3517081 aatatgccca cgatccctca cctcaaacac tctctttgtt aggtttgtaa cagtgtatta 3517141 gcattctttt gggaatatgc taaaaactca ataaggacaa ggggtgaaac gaactttttc 3517201 agattcagca aactatttcg cgtcactaaa ttttcatctt tacaactatt gatcgctcct 3517261 gtaaaatgaa ataagcaatt agttacttag gtaagttttt tagaaggaga ccgacatgtc 3517321 ctacgtcaac agacacctca ttcatcaaat caaccaaagc gcccgcctga ttgccaagaa 3517381 agccaatgaa cagctagagc cattcggcct ttattcatct caatggtcag ttttatattg 3517441 tttgcgtacg atcggaccaa tgactcaaaa agagatttgg tcctatttaa atgtggaagc 3517501 gccgactgtg actcggacga tcaaacgcct ggaggagaac ggctgggttc agagacggca 3517561 aggtgaagac aaacgggaaa aacttgttgt cctcacaaaa gaagccgaga aaaaatacga 3517621 agaaatcaat gtgaaaatgt tgaaattcga ggaagagctg cttgcagatt tccgggatga 3517681 agataaagaa gctttttctc atttattccg catgttttta caacaatgaa aataaggaag 3517741 tgacatacat ttgaaaaaag cggatgcgat atggaccaag gattttatta tggtcctgct 3517801 tgtcaattta tttgtgtttg tgttctttta tacattttta actgtattgc cgatctatac 3517861 actgcaagag cttggcggca cagaatcaca aggcgggctt ttaatcagcc tgttccttct 3517921 gtctgcgatc attacacggc ctttctccgg agccatcgtt gagcgtttcg ggaagaaaag 3517981 aatggcgatt gtatcaatgg cgctcttcgc cctatcatct tttctgtata tgccgattca 3518041 taacttttcc ctgctgctcg gattgcggtt cttccaaggg atttggttca gcattttaac 3518101 gactgttaca ggtgcaattg ccgctgatat tattccagcc aaacggcgcg gtgaagggct 3518161 tggatacttt gccatgtcta tgaacctcgc tatggcgatc gggcctttcc ttggcctgaa 3518221 tttgatgaga gtggtaagct ttcctgtatt ctttacagcc tttgcgctgt ttatggttgc 3518281 gggcttactt gtttcgttct tgataaaagt gccgcaaagt aaggacagcg gcacgactgt 3518341 attccgtttt gcgttctcgg atatgtttga aaagggcgca ctcaaaattg cgacggtcgg 3518401 tttgtttatt tctttctgtt attcaacagt cacatcatat ctgtctgtat tcgccaaatc 3518461 agttgacctt tcggatatca gcggatattt ctttgtttgt tttgcggtga caatgatgat 3518521 tgcacgcccg ttcacaggga aattgttcga caaagtcgga ccgggcattg tcatttatcc 3518581 atcaatcctg attttctctg tcggactctg catgctgtcc ttcacacata gcggcttaat 3518641 gcttctgctt tcaggggcgg ttatcggtct tggctacgga tcaatcgttc cttgcatgca 3518701 aacattggcg attcagaaat ctccggctca ccgctccggt tttgcgacgg caacgttctt 3518761 taccttcttt gacagcggaa ttgctgtagg atcgtatgta ttcggattgt ttgtagcatc 3518821 tgccggcttc tctgccattt atttaacagc ggggctgttc gttttaattg ctctgcttct 3518881 ctacacgtgg agccagaaaa aacctgcaga ggctgaagga aaagtgtcta ttgcagaata 3518941 acttgtcaga ctgccgggaa atcccggcag tcttttttcc attaaaacac ggcgccctct 3519001 cggttgaacg agagaacgcc gcttatagca attattcaat gacaggccgc gcaggtgaat 3519061 caggatctaa cgaaaaatca taggacgctt catcacgaaa catcggatcg gcatatatgg 3519121 attgttgatc gttttttgtt gcttttcgat acgaagaaaa tgaatcatat tctttctttt 3519181 tccacatcca tatgccgtct tgatccgctt ccttgtggta cacgttatga ttgaccgtat 3519241 taccttcgtt ttctgtaaag tcgtttccga taaataatct ggaatcaccg gccgtcaata 3519301 tattcttttc aattgtgttg tttttcgtat cgtactgcag cagcagctgt ccgccgtaca 3519361 gtccctttgt gtcattccgg tacataatat tgcgggcaat cagagaattg ctggtgccgc 3519421 cccgcttttt gtcatatcct ccgattgaaa taccggtgta cgcattgttg tacactttgt 3519481 tgtctgtgat ctgaatggca tttgcatact ttcctttgtg ttcagacgtt gcttcaatcc 3519541 caatatcgtt atcgtaaact gtgttgttct taatttcgat atcgtgtcct ccatcgacat 3519601 aaatcccgcc cgctgagtat tcatctccat aagcaggatt gccgtaagtc gagttttgat 3519661 aaactgtatt gttttctacg actccgtttc gcacgtaatc gtttttatcc gcggttccct 3519721 cataaccaat tagatcaatc ccgatgttat tattgttgcg gaccacattg cctgcaactg 3519781 tgaagccgtc gatattaccg ttcagcacaa ctgcttcact cgctccaagc gtcagtttct 3519841 caactgtatt gtcctcgatt cggatgtctt tcatgctgcc agtcccataa actgcgattc 3519901 cgtgagcatt tccttcatcc gctgttgtct taatcccccg gatgtgatta tccttaatgg 3519961 cgatatgact gctggaccct gatacataaa tccctatagc agttgcttcc tcagatgaaa 3520021 cagaaagatc ttgaattgtt aaaccgctga tggcaatgtc atgtttatcg tgaatacgaa 3520081 taagcggtgt ttcatattca gcgttcgcaa cggattcacc gctaatcacg acgttttcat 3520141 tttcatagtt tcggaatgtg ataggctttc cgtccgtacc gctgtgcttt acatcaaggg 3520201 tctcatgata cgtgccctcc cgaatcatga cagttgtgcc ggcagcagcc ttctcagatg 3520261 cgtgtgccaa tgtacgaaac ggcttttctt ttgttccttc attttgatca ctgccatttg 3520321 gcgaaacata cagataatcc ccagatcctt cctcattcgc ttttgtctta tcataaacga 3520381 aagcgaggat gacagacgtt aaaacacccg ccaaaagaat aaaataccat tttctcattt 3520441 tcgattccca tttcgtttta gaatagattt ctaaaaccat tataaatgtt ctatttatgg 3520501 aaaaccattt caaaaatatg aaaatatacc gtctaaatag atcttattca gcctggcgga 3520561 cctgcgcatg ttcaactgtt tcaattgcca atgatgcagg cgggtgaaca cgcatcagaa 3520621 caatgtagaa aagaaaggaa atcagcacac ctacaaacca agaaatatcg tataagctct 3520681 tcaatacagg aacatacatg ccaatcagcg aaatcagcgc tcctaacatt gtggctgcaa 3520741 acgcacggta attgtagccc ttccaataca cataccgtcc tgtttcggaa tacaggtcat 3520801 ctaccgagag ctcacgtttg cgaatgataa aatagtcggc catcatcacg cctgccaccg 3520861 gtccaagcat gccgcctatt aagccaagaa acgcatacac gcttgtcgcg ctctccatca 3520921 gcttccacgg aaccgtaaat aaagcgagca acgctgtgat aaagctgcca cgtttgaaat 3520981 tgatatattt cggcagggca ttcgctatat cataagcggg tgatacgata ttcgccgcga 3521041 catttacaga gatcgtggcg atgcagagtg tgatcacgga caagacgatg acataagggt 3521101 tatcaaaccg cgccaaaata tcgacaacat cccaaatcgg ctctccgaac gcgacctgcg 3521161 agccggaggt caccgtaata cttgcgaatg cgaacagcgc aaacgttccc ggcaaaccgt 3521221 aaaattgtcc tttgatttgc tctttttgtg tttcagcaaa ccgtgtaaaa tcaggtatat 3521281 ttaagatcaa tgtcgcccag atgccgatga tgccagtaac tccggcagca aacggccaga 3521341 atgtttctga aaacgtatga aactttcctg gttgagagta tatcgggccc aatcctccag 3521401 caatatcaac ggcccaccat accatgccgc caaataccag atacactaaa ggccctgccc 3521461 acacctcaaa acgtttaatc gactccatgc cgtgatgcaa tacgagtaaa tgaatggccc 3521521 aaaagaatac aaaggaaagc aaaccggaca agtgaatgcc gagaatgttc cactcgccgc 3521581 caatttctcc ccaacctggc cacatattca aaagcaaaat gttcagtgcc gtgctacccg 3521641 caaaggtctg gatgccaagc cacatgatag ctgtaaacgc ccttagaagc gcggggatat 3521701 tcgcgccgta tatcccgtaa gaagcccgaa tgatcactgg aaacggcagc ccgtattttg 3521761 tccccgcatg gccgtttaag gcaagagcgc caaataggat aagtgatgcc gtaataatga 3521821 tcgccagcac ctgccaaggc gaaaggccga tcgcaattaa tcctcccacg gtcgcgtagg 3521881 tcggtatgtt atgtatacat cccatccaaa tggaggcaaa gttcattgct ttccacgtcc 3521941 gtttttcctg tcccaaaggc accagatctt cattgctcag cctgttggat tgctgctgac 3522001 tctcttttaa tttcatagcc ggctcccctt tccatattgt ctatatgtcg tcacacgtta 3522061 tgttttttga cattagatgt cacttaatat aactgaagag tcagacaata acactggcta 3522121 tgatatacaa ttttcccgtt tgtatttgaa cagcttaaac aagaaaaaga gacagacctc 3522181 agagcccgtc tctttcttaa gatgcagttt tcattaatgc agcaaatctc acagccatta 3522241 acaggcttgc tccgcccgct ataatcataa tgattcccat catatcaaaa tgggctgccg 3522301 tgatttcttt accaaaaaga atgccaagga tcaccgaaga caaaatcgat cctaggtaac 3522361 ggcaggtttg aaacaggcct gaagtcgttc ctaccatgtt ggaaggactc gtttccagca 3522421 tcgctgcctg aagcgcgaca ttgcccagtc cgtagcctat acccaagagc gacagaatga 3522481 ggcctttacc gatggtctgg acattgataa aaaagatggt taagagcacg gctccagccg 3522541 tcatcaaaag cgctcccgca aagatcggct tgacgacacc agatcggtcg atccatttgc 3522601 cggttagagg tgacacaacg atgctcattc cagacataaa cagcataaac aggccgctcg 3522661 tttgaacaga aagatgcatt tcatcctgaa agtaacttgg caaaccaaaa aataaacaat 3522721 agaagaaaac attcaataaa ataaactgaa catacacggc tgacaggttt cgctgtgttt 3522781 taaacagacg gacatcaata aacggcttat ccgttttcag ctcgcgccag acaaacgcac 3522841 agagcagaag caagccaagc acaccttcaa ccgcatgcgg cgacgtgctg aacgacagca 3522901 aaaaggatag aaggaaaatg attcccccgg caaataaaac aattccaaga atatcgagct 3522961 gccgaataat ggttttgatt cctgcccctt ttttctgatc tttcgggaac atatacaggc 3523021 ccaataagaa gctgaggata ataaacggca aattaacgat aaagatcgcc ggccagcctc 3523081 cccatacaat caaaaacccg ccggctgtcg gccccagcgc cgtcatggcg gacgcaaaaa 3523141 tagagagtac agccaaggct gaagcttggc gctcatgaat atgattccga atcaagccga 3523201 cacctgacgg ataaatcgca ctgctcccca ccgattgaaa cagccgcatg accaataatg 3523261 tcataaacgt cggcgcaaac ggcgccccga tggcagaaac cgcaacaaga ataagcccga 3523321 ataaaaacaa gcgtttccgc ccaatcaaat caccgagctt tcccgttacg ggctgcgcta 3523381 cggcactcgc caagtaaaac gaggaaatca gccaggaaac cgttgtaaac gagaggtgaa 3523441 actcatgctg gatgctatgg agcgcaagag agatcataga cgagttcagc ggattcagca 3523501 ttgttcccga agccacagct gttaaaaaaa cagctcggct ttttttcgat aacatcattt 3523561 cacttgttcc agaaactctt ccgttgtccg cgatttaccg attctcggga aaataaagcg 3523621 cagtgtggct tcatgctctt catcgctaaa tgtggacatg gcatctgtaa taaaaatctg 3523681 ctgatagcca agctgaaatg cctcccgtgc tgtgctttcc accccgatat tcgttgcgat 3523741 gccgcacaat acaatcgtat caatgccgcg acgtctcagc tgcaagtcta aatctgtgcc 3523801 aaaaaaagca ccccattgcc gttttgtcac agtataatcg ccatcctgca caccgatttc 3523861 cggaacaaat tcggcccagt ccgccggcat ttcccctgaa cctccctgcg caggctcatc 3523921 cgtttgcggc ttcagggcgt ccgctccatc atgaaaggct acatttacaa agctgatgaa 3523981 cccgttatgt ttccgaaatt catctacgag ctttttcgcg ttcgggacaa cctggccgct 3524041 ttgatcaatc ggcacaattc ccttttgtaa atcaatgata accaatgctg ttttttgaaa 3524101 atcaatgttg agtgtattca tcatacgtct cctcctgata ctgttagtgt ttctcacatt 3524161 gcatatttta ctcttcacac tgcctaagtt cttttatgat gcttgtgaaa ttctcagaag 3524221 gagcgttttc tcatgatttt tcttttatgt agtagtaaca ggttgtgcat acgaacaaac 3524281 cggcaagcac tgtaatcata aagggcgtca tcgcttcatc acctgcctgc tgtctatcgg 3524341 ttcctgcctg aaaatgccca tgaatttgcg gcggtccatc caaagcagga taagacacat 3524401 aaccattaat atcgtgctaa gatcctgcac gccaatatca aaacaatagt taatcaagac 3524461 gatgttcaca ataatgggca taaaaataac cgcccctaat gcagccgttc gcggaatcag 3524521 taataaaaca gctgccagga tttcaccaaa acctataaac agttcataga catgagaata 3524581 accgaaaaat gtccacgcga tcgtaaaccc cttcccggca gccgcctcga tttcaggcgt 3524641 cacctcgcca aactggccaa ttaccacttt cgccagaccg tacacgaaaa aattaaaggc 3524701 taaaaacaat cggaacgtcg cgggaatcga cttgcgtacc gctttcctca gcctgccgcc 3524761 tttattcatc atacatcccc ctcagtgtat tatttgatgt agtacactta atacagtata 3524821 gagtattcta attaatgtca attccctttt cagctcatat gaatagtttc ttttatagat 3524881 acaaagtctt atatcgcaaa aaatgccatt ctccttcctt tccatccctc gataacattt 3524941 ctcaaaaacc atgtcaggaa atcttacatg aaaatgtttt atcattcttt tttctctata 3525001 atgaagaaat ataataattg ctttttattc tgaaagatac ggaggaatga gacatgcaaa 3525061 tgggcgatac agtttttatg ttcttttgcg ctttactcgt gtggctgatg accccgggat 3525121 tagcgttatt ttatggagga atggtaaaga gcaaaaatgt gctgagcact gccatgcaca 3525181 gtttctcttc cattgccatc gtttccatcg tttgggtgct gttcggatat acacttgcct 3525241 tcgcaccagg caattcaatc atcggcgggc tggagtgggc aggcctcaaa ggggtcggat 3525301 ttgatccggg agattacagc gataccatcc cccactcgtt atttatgatg ttccaaatga 3525361 cgttcgccgt tctgactaca gcgattattt ccggggcttt cgcagagcgg atgcgattcg 3525421 gcgcttttct tttattctcg gttttatggg cctctttggt ttacacaccc gtagcgcact 3525481 gggtatgggg cggcggctgg atcggccagc ttggagcgct cgatttcgct ggcggcaatg 3525541 ttgttcatat ttcctccggg gtggcaggac ttgttcttgc cattgtgctc ggcaaacgga 3525601 aagacggtac agcgtcttct ccgcataacc tcatttacac cttcttagga ggagctttga 3525661 tttggttcgg ctggttcggc tttaacgtcg gcagcgcatt gaccttagat ggtgtggcca 3525721 tgtacgcgtt catcaacaca aacaccgcgg ctgcagccgg gatcgccggc tggatcttag 3525781 tagaatggat cattaacaaa aaaccgacaa tgctcggagc ggtatctggg gcaatcgccg 3525841 ggcttgtcgc cattacgccg gctgccggat ttgtcacacc gttcgcttcc attattatcg 3525901 gcatcatcgg cggagctgtt tgtttctggg gagtattctc gcttaaaaag aaattcggat 3525961 acgacgacgc gcttgacgcc tttggcctgc acgggatcgg cggcacatgg ggcggaatcg 3526021 caacaggatt attcgcaaca acctctgtta actcagcggg cgcagatggg ttattttacg 3526081 gtgatgcaag cttaatctgg aaacaaatcg tcgccatcgc cgccacttat gtttttgtat 3526141 ttattgtcac tttcgttatt attaaaattg taagcctctt ccttcccctt cgcgcaactg 3526201 aagaagaaga gtcacttggg cttgacttaa cgatgcacgg ggaaaaagca tatcaagatt 3526261 ctatgtgagg agtgacgcta tgagcggtca aatgttcaag gtagaaattg taacgcgtcc 3526321 ggcaaatttt gaaaagctga agcaggaact cggaaaaatc ggagtgacct ctctgacttt 3526381 ctccaatgta cacggctgcg gccttcaaaa agcacatacg gagctctatc gaggggtaaa 3526441 aatagaaagc aatgtatacg agcgtttaaa aatagaaatt gtggtcagca aggttcctgt 3526501 tgatcaagtg acagagaccg ctaaaagggt gctgaaaacg ggatcaccag gtgacggtaa 3526561 aatatttgtc tatgaaatca gcaatacgat caacatccgc acaggcgaag aaggacctga 3526621 agcactttaa tatcggtacg agattcggac actccggatc tctttttttg tgcacagaat 3526681 ccccccagaa accgcgattc ctcttcgaat tctcttcaag cgccgttatt tcagacaatc 3526741 tctattttta tttgaaactt ttcatgagta agattagtct actaaatata aaaatgtaaa 3526801 aggtgattat ttgaactacg aaatttttaa agcaatccat ggactatctc atcacaattc 3526861 agttctcgat tccattatgg tcttcatcac ggaatatgcc attgtcgcct atgcccttat 3526921 cctattggca atctggctgt ttgggaacac acaaagcaga aaacatgtgc tatacgcagg 3526981 catcacagga attgcaggcc ttgtgatcaa ctatttgatt acgcttgttt atttcgaacc 3527041 gcgcccgttc gttgcgcata cagtgcatac actgattccg catgctgcgg atgcttcatt 3527101 tccaagtgac catacgacag gtgcattagc gatttctatt gcgatgcttt tcagaaaccg 3527161 caaaatcggc tggccgcttg tcatttttgg gcttttgaca ggcttttcga gaatttgggt 3527221 gggacatcac tatccggtag atgtattggg cagcctcgtt gtcgccatca ttatcgggtt 3527281 ccttttcttt agattttcag atctgcttcg cccgttcgtc gatttggtcg tgaggatcta 3527341 cgaagccatt atcaataaac tgacgaaaaa accaaccgat caaaatttct aagaaagaca 3527401 aaagccggcg tctgaaatca agacagccgg ctttaatatt tctcatacat ctcttgtttt 3527461 cttcgcttcg ccaacacata taaaccataa aacaacccaa ttccaacagc atcgatgagc 3527521 acatcccgga tacaaccatt cctgctgaag aagagctgaa gaacttctgt gaaaaaagca 3527581 aacgcaaatg agccggctgc agctgatctt atgctgcccc gctgtttcca cagcaaatat 3527641 gtcagcacaa agaaggaaaa cgcgtgtccg attttttgaa taaacgcttc aggtacagta 3527701 agctcagtaa aatccataac taaaaattga gacagatcag ggtgcggctg aaaatgaaaa 3527761 gccaccgttt gcgatacgac catgccgctg aagctttccg tacagacaga aagcaggata 3527821 aaaaagatcc agcctgcgag caataggcgg ttcatgacat aacctccttt ataacgtacg 3527881 tgcctacatg taactacata gacggtaaaa caaagcaaaa agtaacagaa aaaaacgccc 3527941 atcacaagga tagacgtttt cttcattaag actgttcagt gtcttctgtt gtgctgcttt 3528001 ctttagaacc agatttgtca gttgaatcat cctttttctc accggatttt tcttctgttc 3528061 ctttttcagt tgatccgtcc tttttctcgg aagattgctg aatggattct tctgtttctt 3528121 gggtggcagc tttttcaata gaagaaactg gtttgtccat aaagtttaac ggattcattg 3528181 caaccccatc tttacggatt tcaaagtgca cgtggtttcc gctgtcttca ctgtaaaggt 3528241 tcttgccaga ttttccgatc acttgatttt gttttacttt gtcaccttgc tctacgctta 3528301 cttcggaaag agattgatac acagtcgata aaccgtcggc atgttctact tccacaacat 3528361 atcccagcac tggatctttt tcagctttaa caaccgtacc gctcagagaa gcagagacat 3528421 cgaaatcttt tccgtctttc tcagctaagt caattccttt gcttaggctg tacgtgttat 3528481 tataggtaac gagtgctgct tctttctctt cttttgcggc atcggtttca tagaactttt 3528541 tcacaacaga aacgttttca gaatcaacaa ccggcattgc gacattttcc attgactttc 3528601 ctacttcaac tgcatcgtcg ttgttgtcat atgcggagtt tccgccgtta tcagccaact 3528661 gatcctttac ctcatcattt gatactgatt gataccaaag gacagctgtt aaaatgacgg 3528721 ccgcactgac taagtaaatt gcagggaaca cccagcgttt acgaaaaaac tgctgaagtt 3528781 ttttgacttg agaagttttc ttttcttcct ctctcattgt ttcatcacct cagcaacatt 3528841 ctgaacactt ttctgaaaat atatacaacc tatccaaaaa aactttttta gatgtagttt 3528901 gcacagactg aacgaaaata tgtatttttt tgagaggagt gccaaaaacg tatgaacatg 3528961 acattgcgtc ttgctgaaca tagagacttg gaggctgttg tggcgattta taattcaacg 3529021 attgcttctc gaatggtaac agccgatacc gaaccggtaa ctcctgaaga ccggatggaa 3529081 tggttttcgg gacatacaga gtcacgtccg ctctatgtgg ccgaggatga aaacggaaac 3529141 gtcgctgcct ggatcagctt tgaaacattt tatggaaggc cagcctataa taaaacagcg 3529201 gaagtcagca tatacattga cgaagcatgc cgcggcaaag gtgttggatc atatttgctt 3529261 caagaagcgc tccgcattgc cccgaatctt ggcatccgct cacttatggc cttcattttc 3529321 gggcataata aaccaagcct gaagctgttt gaaaagcacg ggtttgcaga atggggacta 3529381 ttccccggca tcgccgaaat ggacgggaaa agatacgatt taaaaatttt agggagagag 3529441 ctttcatgat tagtctggat aaagatgaaa acgaaattga acatcataat gaagaaaata 3529501 gccttgttga acaggagact gcacctgttg gacaggagag ccgccagctg agcgcctccg 3529561 ctgtcaagtc gctatccgac attgccaagt ggggcaaaat ttctggcatc ttgttaatca 3529621 ttatgggatc gcttgtcact ctgtctgttt tgatgacagt gattggcgcc atcccgggcg 3529681 tactgctcat tatttcaggc gtatttttga tgcgctcagc aaaagcagcc gcggaagccg 3529741 aaggaaatct aaccggcagc gctggcgaaa gcatgcttga aaattacggg acatttataa 3529801 aaatgcagct gttttatgca gcatccagta tcgttactgt cctgatcggg atcattgtag 3529861 ccattttcgt gctggtggta atcggcattg ctgcttttga gaacacgcct tcgtatgatg 3529921 atccggattc ttattattat gaggatgatc cggtgtttga ataatgatga gacaggacag 3529981 ggcatgagtt ccatataaac ggaaccatgc ctattttatt tgactattca aagcaggccg 3530041 gcgtaaacac caaatcctga agcaagcata caatagacat ctctagtaga ggaaatcaac 3530101 aaagcaacgc tgttacccag aaatgaatat caaaaaaacg gatgaagtcg gaatcaatcc 3530161 gaaaccgcac tttttatttc gggtgtctgc atgcaaaaaa acacacccgg atcgtctgga 3530221 aaatctcaac aatccgggtg cagatcttct ttaatacatt tttttgcgtc tgtcttcctc 3530281 agtcaaaaat tcaacaaaac tccgcatcgc aaaaggctct tcctttattt gtcgtgcgta 3530341 ggagcttttc cgctcttctg aaaggatttc gctctttttg atcctgttca gcatatagat 3530401 gtgaaccgtt ttttggattt gtttatgctg atagcctgcc tctttaaaaa atgcgagccc 3530461 gagcgccgcc aaaagggcga atatgcctgc gctgatcagg gactccctgt cagctgaagc 3530521 atgaaataga aaagcagcta aattaaagag agagaatgca gcaagcggaa tagcaagaaa 3530581 acggtaaatg acggtttttt tcatgaaagg ctgtacggcc ttttgaattt tttgcatttc 3530641 tgttttgatg aaccccggca tttgttcgac tctgtaaaag ttcatataat cctccccctt 3530701 tatttgatgt ttcaagcttc acgaacgtta tcatatgtgt ttattttaac gcaggtgcaa 3530761 gctggtttta aagaaatctg cccgtatttt tcacgaagaa tctggatcgc cgctctttat 3530821 tcttttaaaa tgtgagtgtt ataatttgta atgggaatca gatcactgtt attcatggaa 3530881 tactaatggc aatcttcttg ataaatatga atgagcgggg ttacaaagtg agtatttctt 3530941 ccatcctttt atcacttttt ttcattttaa atattctttt ggccatcatt gtcatcttca 3531001 aagaacggcg cgatgccagt gcatcttggg cgtggctgct tgttcttttc tttattcccg 3531061 ttttaggctt tattttatac ttattattcg gccataatct cagacgcaag catttgtttc 3531121 aatgggaaga ccggaaaaag attggaattg aaaggctgct gaagcatcag cttgaagatt 3531181 tagaaaccaa gcaatttcag tttaacaacc gggcaacctt tgataacaaa gatttaattt 3531241 atatgctgat tatgaataac catgctgtgt ttacagagga taattcagtt gacgtcatta 3531301 cagatggacg ggataaattt cagcggctgc tgagtgacat ttcaaaggct aaggatcata 3531361 tccatttaca gtattatatt tataaaggcg atgaattagg caaaaaattg cgggacgctc 3531421 tcatccaaaa ggcgaaagaa ggtgttcagg tcagagtgct ttatgatgaa ctcgggtcca 3531481 gaacgctgag aaaaaagttt tttaaagagc ttcgcgaggc tggcgggcat gtggaggtct 3531541 ttttcccgtc aaagctcagg ccgattaacc tgcggctgaa ttaccggaac catcgaaagc 3531601 ttgtgatcat agacggtatg accggttatg tcggaggctt taacgtcgga gatgagtatc 3531661 tagggcttaa tccgaaattc ggttattggc gggatacgca tatccggctg caaggaacgg 3531721 ccgtgcacgc catccaaaca cgattcatcc ttgactggaa ccaagcttct catcaccata 3531781 cgctgacata tattccaaat cactttcctg attacggccc aaaaggcaac gtcgggatgc 3531841 agattgtcac aagcggccct gattcggaat gggaacaaat taaaaatggc tacatcaaaa 3531901 tgatttcgaa cgccaagcgt tccattttga tacaaacacc ttattttatc ccagatgcaa 3531961 gcctgctgga tgctttaagg atcgcttgcc tttcgggcat tgacgttaac attatgattc 3532021 cgaacaagcc cgatcacgcc tttgtatact gggcgacact ttcgtatatc ggcgatctgc 3532081 tgaaagccgg agccactgtc tatatttacg ataacggctt tattcacgcg aaaaccatcg 3532141 tggtggatga cgaaatcgct tcagtcggca cagcgaacat tgatgtccga agcttcaggc 3532201 tgaattttga ggttaatgca tttatttacg atatcaccat tgctaaaaaa ctggtttcaa 3532261 cttttaaaga agatttgcta gtatccagaa aattcaccta tgaggagtat ctgcagcgcc 3532321 cgttgtggat tcgaataaaa gaatccgtct cgcggctgtt gtcgccgatc ttataagatg 3532381 cgtaaacccc cggcctttac ggccgggggt tttcctgatg gtcacagtaa atgatgattg 3532441 cctcccgcaa aaaagcggca agaccttctc catattgatt gattgaatcg gtaaatcgct 3532501 cgtcagtgat atacacttcc ccgagtcctc tgaaaatgtc gagtgtgcaa tcgtaatgat 3532561 attggcaaat atgatcgcga aatgccccca cagcggcctg aatctctgca tcatcgggcc 3532621 catgcttcat tcgcgccgca attcgtctgt aaatcgaatc aaattcagcc atgatcgtgc 3532681 gccaatcatc tgccgagtat gcagatgtcc ttttctctgt ttcttctgcg atttcctttc 3532741 catacagctt tctgacttca tcagcgtatg tctgctggtg ctcttcaatg tctttcatgc 3532801 ttaatccggc aaataaatcc ctcttattca tcgtttcccc tccatcaacg gacaaaagcg 3532861 tcctgtcaat tgtttgaatc atctcatcca ttctttgttt tttcttcatc aatatctcct 3532921 tttgcgactg aagtgccgct ttccggtcaa aattcggatg atccagcatc tctttaatct 3532981 catccagacg aaacccgatt tccttgaaaa ataaaatctg ttgcagtctt tccaggtctg 3533041 cgtcactgta caaacgatac ccagcatcag taagcgctga aggattcaga agctcaatat 3533101 tgtcatagtg atgaagcgtc cgaatgctaa cgcctgatat ctccgccact tgtttaactt 3533161 gatatttcat acataacacc tcctcttttt tatcgtaaac aatcacgcaa cgttagggtc 3533221 aatccccaaa atgttatttt ctatatacaa aacttctcac aaatagtgta taaaagaaaa 3533281 gtgagtattt ttttgtaaag gggagccagt atacatgaat cctgaaacaa tgaacaaaac 3533341 cctcatcagc atttcgaaat ggggaaaagc tacaggcatt ttatttatta ttatgggcgc 3533401 aattaccgcg ctttcaggcg cgttcttttt tctaatcggt gccgtgccag gcgtactgca 3533461 aattatttcc ggtatctttt tgatgaggtc agctagggaa gcaggccaaa tggctgaaca 3533521 caatagcgga cagtctgaag acttaatgct ggagaattac gcgaaattcg taaagatgca 3533581 agggatttat ttgatcgtaa gcattgctgt atccattctt gcgattatcg ccttcttcat 3533641 ctttttaatg cttgggattg ctgacggcct tttcagcgat acgtacagca cttattaatg 3533701 agaaaaaccc ggagctggct ccgggttttt tattattccg cttcgcttac cactgtgaag 3533761 cgttcatttt tgtgttcggg atgttcaagc tcgtccaaca cggcaatggc ataatctgca 3533821 tagctgatat agctgtctcc ttttgcattt acgatgacat tgtcttttcc tttttggtaa 3533881 gagccagtcc gttttcctgc tggatcaaaa aatgccgcag gactgaggaa cgtccaggaa 3533941 atggagtctg tctgctgcaa atctttcagg ttctcgcctt gatttgatgc agttggcaaa 3534001 tattctttcg gaaattccgg cgtatccatt aaacgggttg ttttggcttc atcaacaaac 3534061 aggcttcccg ctccgccaac aacaagcaat cttgtgtgct tcgcgtcctt taaaatgctg 3534121 atgagtgctc ttcctgcttc aacatgaaga tgttcttggc cgggtgctgc tccaaaagcg 3534181 tttacgaccg cgtcgaaagg cttgatgtct tccgcagtca gttcaaacac atctttttcc 3534241 aaaatcgcta cgtcttgctc ctgcactttt gaagcgtttc tgacgatggc tgtcacttca 3534301 tggcctcttt ttttcgcttc tttcaaaatc tcgtttcccg ctttcccgct tgcgcctata 3534361 ataccaattt tcatttttca tttcctcctt atttgtaaca attttagtta catgttagcg 3534421 gtgagaagtc atcccttttg attaaaagag atgattcata acatctttta atgacttgct 3534481 tgccagttca ttttccatcg ctctttgcac actttcaaac gtttcatcca gagcgttctg 3534541 aatttttttc cctaccggac atttcggatt cgggttttca tgaaccgcaa agagttcttc 3534601 ttgcttttgg acagcccggt acacttctaa aagagaaata tcagcaggat cttttttgag 3534661 gcttgcaccc ggcaccccgg cgcgtgatgt gagaatatca gcttttttca gcaggctgat 3534721 cattcttcgc acaactaccg gattcgtgtt gacactgtct gcaatgattt ctgaagatgt 3534781 tttttcatcc atcgagatga gggataaaat atgaatggca acagcaagac ggctgttaat 3534841 catgtttttt caccaccgtt gtaactataa tagttacatt tgattcgttt gtcaacatct 3534901 aatatacact aaatacatgg gttttgtgca ccgtttttag tcaatagaac ggccggatgc 3534961 actccggccg cgtcttatca aaataagaaa tatctttgtc caagtgggac ataatcgaca 3535021 ggctggcaag acaattcctc cccgtcagca aagacctgat aggtttttgg atcaatctca 3535081 atcttcggca aagccgaatt cagcttcata tccagcttgc tcagctttct gatatttttg 3535141 actggagaaa tccttttttc cagccctaag ctttccgcca caccacgctc tatgcttgcc 3535201 tgagacataa atgtaatcga ggttgagcgg ttggcttttc cgtaagacgc atacatttgg 3535261 cgcatgaaaa ccggttcagg agtcgggatg gacgcgttcg gatctcccat ttgcgcacgt 3535321 gcaatcatgc cgccctttaa gaccagttcc ggtttcacgc cgaaaaatac cgggtcccac 3535381 agaacgagat cagcaagctt ccctttttcc accgagccga cctcatggct gagcccgtgc 3535441 gtaattgccg gattaatcgt gtatttggca atgtaccgtt ttgcgcgcac attgtcattc 3535501 ccgttttcac cggcaagagc gccgcgctgt tttttcattt tatcggctac ctgccatgtt 3535561 cggatgatca cttcaccgac ccgccccatc gcttgggaat ccgatgatgt catgctgatc 3535621 gcacctatat catggagaat atcctccgcg gcaatcgtcg ccgccctgat tctggaatgg 3535681 ctgaatgcca catcttcagg cactttcgca tctaaatggt ggcagaccat catcatgtca 3535741 agatgctcat ccatcgtatt aacggtataa ggaatggttg gcgttgtaga tgacggcaga 3535801 atgttcgcgt aagaggcgag cttcataata tccggagcgt gaccgccgcc tgccccttca 3535861 atgtgataag tatgaataac ccggtccccg atcgcgtcga gcgtgttttc caaaaagccc 3535921 gcttcgttaa tcgtatcggt atggatggca acttgaatat cagcctcgtc cacgacttcc 3535981 atacacgttt taatggcgct tggcgtcgtt ccccagtctt catggagctt aagaccgatg 3536041 gcgcctgctt ccacctgctc gatcagcggc gctttatcgg atgcattccc ttttcctaag 3536101 aagccgacat tgatcggaaa ctcctcggcc gcttccagca tcctcgccat ataccacgcc 3536161 ccggacgtac atgttgtcgc tttgcttcct gtagcgggtc ctgttccgcc tcccaaaagg 3536221 gtcgtcacac ctgaagaaag cgcaacttcc atctgctgag gacaaataaa atgaatgtgc 3536281 gtgtccactc ccccggctgt taaaattttg ccttcaccgg aaatcacctc tgtccccgct 3536341 ccgatgacca tgtgcggatc gactccatcc atgatatcag gatttccgct ttttccgaca 3536401 ccgacaatcc ggccgtcttt cacaccgaca tccgctttga caatgcctgt gtaatccaat 3536461 agcacgacgt tggtgataac caaatccaaa gcgccgtcct tccctgtgat tctgccgttt 3536521 tggcccatgc cgtctcggat agtttttccg ccgccaaaga tcatttcttc accgtatact 3536581 gtgaaatcct tttcgacttc gatccataaa tccgtgtcgc ccaatctgat tttatcgccc 3536641 gttgtcgggc caaacagttc cgcatattcc tcccgtgaca ttttcatcgg attacaccct 3536701 ccatccagcc ggcttgtttt aagttggcca acgttttttc tttgccgcgt tcatcgataa 3536761 acgtgtcggc cattccgttc agccctctaa ttgtcttgcg tcctctgatt tccactagtg 3536821 agaccgtttt ctgctctccc ggctcaaaac ggaccgacgt gcctgatgga acatcaagac 3536881 gcatgccgat cgccagctca cggtcaaata ataaagcccc gttggcctcc gcaaaatgaa 3536941 aatgcgaacc gacttgaatg gagcgtgatc cggtgttttt taccgttacc tcccgtatct 3537001 cacggccttc attaatcgta atggttccct cagcaatttg aaatgctccc ggcttcatga 3537061 cttcacctcc gcagaaattg gctgatgtac cgtaacaagc tttacaccat ccggaaatgt 3537121 ggcctccacc tgaatgctgt ccagcatctc aggcacaccc tccatcacat ctttttccgt 3537181 taatacatgg cggccggctt ccatcagctc tgctactccc ttcccatcac gtgcgccttc 3537241 cataataaag caggtgatat aagcagcagc ctcaggatag ttcagcagaa cgccccgcgc 3537301 ctttcgctgt ttggctaatt cccccgctgc aaaaatgagc aatttctctt gttcaactgg 3537361 tgtcagtttc atctgtagtc ctccttcttt tgtcatataa agcagatgcg gctactacga 3537421 atttgcggaa cagtcaggcg ggacatcacc tccctttctt cgagaatggg ggtcatacgg 3537481 taagatgcct ttcaaagcgg catgccgttt cttcatcagc cttgccatgg tcaacaaccg 3537541 ttcccctgtc gatcacggaa agatcagatt aacgcgtttt ccagactgcg ctcgactaag 3537601 ataacaaatg tctttttttc tggaaatttc tataataact tgtctgacta gttcgacaat 3537661 taaaatctga attccttcca attgtttatt aagtaaaata tttttcagat ttaccatcag 3537721 cgctctggtg attgcaagct gctgctgttg accgcctttt cgttttgaac aaacgtttga 3537781 ttaaaacaaa tagccccctc tgtttagccg gagtcggcct aatacagcga caatctgccc 3537841 cgggcgaagc taaggctgtg caaaaccatc gattgatcat aaccagacgt tacattcctg 3537901 atggcagccc gttgttttgc tccgcaaccg gaagcatggc atggaggcca gtctgaggcg 3537961 ccgacctcca cgataccgag aacccgacta ttgccattaa ctccgcatca tggacggtca 3538021 cttcgctgat cgccaccgtt cctcttaatg agtgaagaat tccggccttc actgaatccc 3538081 cgcttgtgtc gatatcaact gttttctcgc actcccgtgg cttccgacac tttcttcggt 3538141 gcagtacatt ccgtcatcaa aacccctttg tttgatttct tcaaatgatg ttataaaagt 3538201 ttacaactta tgtcatcatt atatagaaga ggcctattaa ttcaaagaat atttaaaaaa 3538261 tttagttacc ttgaccaaat cagcttcttt ttttgttata tttattcaca tcagaaaaag 3538321 cgaaaaaaaa gacaagaaac atttcgtttc ctgcctcttc cgtacgatta atctttatct 3538381 gaaaatttat ccttggcttt cccgatatcc ttttggattt cgccttttgc cttatctttt 3538441 ttgccttcag cctgcatgtc cgttctgtca gccatatctc cgactttatc cttcacttct 3538501 cctttggctt tattgaagcc gcccttcatt ttgtctttta cactatcgtt acccatgtta 3538561 attctcccct ctcaattatg tgtgtacttg ttaacttccc gatctgagag gcaataaaca 3538621 ttctaatgtt atttatcgat ttcgtagcgc tctccgtaac ggagcacctt gtatatcgcc 3538681 agcccgtctg atgacttttt ctccgaatat cggaccggca gcagggcaaa aaacacataa 3538741 tacgtagaaa aatagacaaa ctgatagaaa aacacattcg gctttaatac actgtgtata 3538801 atcagcagat tgattgcaaa aatcgtgatg aggttaaaca agcagccccc tgcatacacg 3538861 agtgcatttg agaatcgatt gtcaattttc aactccccgt accggcaaaa agaatcgata 3538921 aaataaatcg ttctgaaccg tatgggtcca attttaagca gcgtttttcc catgcctata 3538981 tccaacgatc cctttccgcc aaaaataaaa gccataaagc tgtgccctga aacatgtata 3539041 atctgtacaa gcggcagaac aatgaggaaa gaccacagaa acttcaccat atcattaaaa 3539101 ccaaacattg aattccccct cacatgcata tctgcatccc aaaacggctt ttgttcaaaa 3539161 aacagtgctg tagcgatttt tcctgttctc cccggaaata aacgttccga tgctcccctt 3539221 tttttgcata aaaaaaaacc atctgccagc agatggtttt gtctcatact tcatataaac 3539281 aatcgttcct ttgaatcatc tctctcatgc tgaccgcttt ttcataaaaa tacaccgctt 3539341 ctttatattg ttcgcgatga ctgaaataag aggcagcatc taaagcaaat tcttcaatat 3539401 atacatacag gcccttttct tccatataat caaatacttc ttgaatcata ttcaaattga 3539461 cagattccac atataatgcc tgcagaaatt tatattttgc cagactgaag aagtcgtttc 3539521 gtttttgggc aatggcaatc cctttttcat agtaccgtat cgcggcttcg ctatcttgtt 3539581 ttttgaaaag aacgcgagtc aggctgaaga gcgcttttgg aagctgttcc agctgataat 3539641 cctcgaagac aggaagcgct ttttcaaagt attcggcggc ctgatccagc tcccccttgt 3539701 catcatagca attaccaata ttataaaggg ctgatccgat caaacggggc tgtccttcca 3539761 ataaagcaag gcgatacgcg tcatctaaat gttcaagcgc tttttcataa tttctgtagt 3539821 caatgtagtt tcctgatatg acgaaatggc attgaattct tctgactctg taaaaatcgt 3539881 gagccttata cgtctccagc gcctgtacgg catggttcat ggaaaagtgc gtctgcttca 3539941 taatataaaa gacttccgcc actttaaaat gaaattccgc tctttcaatt tcatcttcta 3540001 caaacgcaag catcttctca gctttccgat aaaaggatat agccgagatg taattgttct 3540061 gttcaaattc gtacattcct ctaaacaagt gaaaataata ctcagataat ccggagatgc 3540121 tgtcctgatt gctttccagc gttttgatca attcacgata ttgaagctga gattcctcgt 3540181 gcaggtcagg ctttacataa tccagcataa tttggtgccg gtagctgatc agctgataat 3540241 acaggagaag cagctgatcc tcttccatct gttcgatatc tagatcaatt tcttctttca 3540301 gttttacggc atcagccact tgaaatgcta aaatgtgctt ataccactta ttgattttca 3540361 ctcctacttg agatgacggg atctcgtacg cggccatgcc cctccaaccc tttctatttt 3540421 ctaattggtt atattttatc ataatgtatg gctttggaat taaattttct tacaatgatt 3540481 ccttctttat gcctatcctt atatatttcg gtttttctac gtattttttg cactcggatt 3540541 ctaataaaaa agcttaccgg acagtgccga taagcttttg acttcaaatt aaccgccaat 3540601 ataagacatt tccactttct ttttgccaga tgcttttgat agcgtacgat cgactgaata 3540661 ctgatcgatc cgatttttcc atactgtccc gatcatttct gatagttcgt catcacttaa 3540721 ttcctggcga accggagctc tgaggtcaaa tccgcttgaa gcgaataagc aggtaaacag 3540781 ctctcctctc gcagaaagac gggctctgtt gcaagatccg cagaatgcat cagatacaga 3540841 tgatatgacg ccaatttctc cggagccgtc caagtagcgg aatctggaag ccacttcgcc 3540901 tatataatta ggcgctatcg gctcaaccgg catgtgttta ttgatcaaat ctatgatttc 3540961 cgcctttgtc atgacgtctt tcttttccca ttggttggtg ttgcctacgt ccataaattc 3541021 aatgaatctc aggatatgcc ctttttcttt aaaataacgg gccataggca gtatatcttt 3541081 ttcattgacg cccttttgaa cgaccatatt gattttaaca ccgagccccg cttgcttcgc 3541141 cgcttcaatg ccttccagca ccttgctgac agaaacaccg cgcccgttta tcttcttaaa 3541201 acgctcgtct tctaaagaat caaggctgat cgtaaccctt ttcagcccag cctccttgag 3541261 cctcttagca taaacaggca gcagtgatcc gtttgtcgtc atcgcgatgt cacgaatacc 3541321 cggtatgcgg gccagttttt tgattaattc cggcatatcc tttctcatga ggggctctcc 3541381 gccggtcaag cggatttttt caacgccaaa tcttgtgaca aacaatgtcg caagccgttc 3541441 cagctcctca aatgaaagca gctcctcttt ctttaaaaaa ggataatccg ggccgaataa 3541501 ttcggcgggc atacagtacg tgcatcggaa gttgcagcgg tctgtaacag aaatgcgaag 3541561 gtctctcagc ggtctgtttc ttttatccaa catctgacgc gactctgtaa tcatagctac 3541621 agccccttcc tactccctga ttctctcagg gtgtgtatat acattaaatg atccgtttct 3541681 gacaaatcca atcgctgtga tattcaattc ttcagccatt tgaatcgcaa gctccgtcgg 3541741 ggccgatttg gaaatgacaa tcgacacgcc gattttggcc gcttttaaca ggacctctga 3541801 tgagattctg ccgctgaaca caatcagttt gtcgcgtacg gacatcccgt ttagaaggca 3541861 gtgtccgtat agtttatcaa gtgcgttgtg ccgaccgata tctgtgcgca tcaacagaag 3541921 cttctctgtg tcgcaaagcg ccgcattatg gacgcctccc gtatcctgaa acgtcccgct 3541981 cccttgctgc atgtctttca taagcgccag acatgcctca ggcgatatct tgatttggct 3542041 gacagccgtc ttggctgttt tgacatcctg ctgaaaataa aaatgacggc cctttccgca 3542101 gcatgagccg atcacccgtt tcgtataatc cttttgatcc aatgtctcag ggtgaacgag 3542161 gtcgacatat acaaaaccga gactttcatc tattgtaaac cttttaattt ctttttgaaa 3542221 tcgtataaca ccctctgatg cgagaaatcc gatgacaagc tcttcgatat gctcaggcgt 3542281 acaaacgagc gtcacaaatt cactgccatt cagtatcact gtcaaaggga attccgtcac 3542341 catccggtct tctactttgc ttatttcccc ttgttcatag cgccatacat ccctgaccgc 3542401 agttacttta tcgttcaatg tctcttcccc tccgcaatgt tcctgccttt atattttttc 3542461 acactcctcg gattttgtcg aattctgaga cacaaaaaga gccctctata taaagggctt 3542521 ttacaggatg tgatgacggc ggtgtttagg caggacgcct aagcatttag ccgccgttcc 3542581 ttttataaca cgtgagcacc aatgtgcatt gacaacgaac gcggggtttg tcgacacgct 3542641 gagacacctc tgtataaagg actctatgtt tgattatgct gattcttttt cagaaccgta 3542701 aacagcacaa tagctgcgat caaggtgaga atgctgacaa aaaagaaggc tgccagtttt 3542761 agaagaacac caagcaatat aaatgcaacg gtggctataa gaaaaatcat tccgaataat 3542821 ttcatatgtt caaccccttt ttagggtatc attcccgccc aaactgtttt taaaccaata 3542881 aaaaaggcgc ctgggggagc gcctgatctt taggttcctt actcagtaaa tttttgtgct 3542941 tctttttccc aagcctgttc gaactcatcc gcactgttcg ctgaaatata ttctccgccg 3543001 ccagcgacag ctgcttgttt catctcttca ttacccttga catcaaagtt gaagccaatg 3543061 atgtttacaa tcgtatccac atttgatgca cggagctttt cgatttccgc cgcagggtct 3543121 ccgccgcacg tttcttcacc gtcagtgatt aaatacacca cgtttttccc gtctgcgtca 3543181 aatgcttcaa attcttttct tgtgtctgca agtgctttgg caatcggtgt ccatccagtc 3543241 ggcttgagct cactcaatga attgtcaaac agagaccctt catatggatg aaggccgtaa 3543301 atggtttccg tcgtactgca cgaaagggct ttaccggaca gtttattgtt ccctgcatgc 3543361 ccgaaaacgc gaagcataag atttgtatcc tttggaagaa gttcggcaaa agattttact 3543421 gattttttgg caatgtctat tttgcgctct cctcctgttt tttgaaccat gcttccgctt 3543481 ccgtcaaaca aaacagctac atttgtatca gcctgtttct cagcggcaaa agacggggag 3543541 gcaatggaaa cagtcaacaa tccaatgata ccggcagcca gcaatttttt catatgatta 3543601 cttcctttct ttttcatatt ttccaactat atgttggatt cttctttatg ctagaatacg 3543661 aaaatgcaaa aagatatagg acatgctgcc ttttgtgctg ctttcacgat ctgtccaaaa 3543721 tcgcttgaaa tgccgttcat ttttagccat ttccgcccag aaagcataaa cagcttgtgt 3543781 gatcattcat tcttttttcg ccttgattat gacagaaaaa cggaaatctg ctactatgct 3543841 acaggcagac agctaattag ttttgaagtt tttgttacat acaaaaagag gctgaccatc 3543901 accagcctct tttttcttat ttagataaca ttagtgattg ctgagtgaaa attttctcaa 3543961 catctttttg ggtataagcc gggaagtatt caccgccgcc tactttcgca attgcgttca 3544021 gctggccttt gtatccctct ttataatcaa agccgatcac attaacagtg atattgtctt 3544081 tttgcagttc ctttgctgtt ttaatcgggt ttcctccgca cgtttcctca ccgtctgtca 3544141 acagatacac cactttttcc ccttttgcat caagctggtc aaaagaagat ttcgcctcgt 3544201 tcagcgcttt ggcaattggc gtccagccag tcggcccaat tgtattgaga gaattgagga 3544261 agctttgctc gttaaagctt tggaagccgt atacgttgcg aatggcttca catgactgaa 3544321 cttttccgga atttttattg tttccttcag agccaaacac gctcattttc acctgagttc 3544381 cttctggcaa tgagctcgca aactttgaaa tttctttttt ggctgaatta aatttagata 3544441 caccatctat tcttttcgcc atacttccgc tggcatcaag caagaccgcc acgttcgccg 3544501 gcgctttagc ctccgtttct gtcttttcag ctgcaaaagc aggtgaagtt aatccaaaaa 3544561 gcaatcctgt catcatgatc agtgaaaatc ttttcttcat gttcgtaccc ctttaccaat 3544621 ttgtttctgc gtgcagatgt tcaacgctga acataatcta tcgtaatcaa caaaaaccga 3544681 gaaataaata gggcgggctt ccccattgct gttgtttact tttgcataga aacctatgtt 3544741 tttattagtg atttccacct aacgccccta tgaaaagaga agattgtccg cctttcggct 3544801 ttcgttatat gagtctgtcg aagtctgtcg acaaatgtgg atgactttac cacaatctca 3544861 aagcctgaaa tcaggaaaaa aggactgatc cttaaagacg gtcagaagct cctctaaacc 3544921 gtttcagcta ctcttagata aaagatattc aggaacagaa aaagacgccc aatgagcgtc 3544981 tttttctact ttttcgccat atatttattc aaaaacgcat ctgcctcaga aatttgtgtg 3545041 ccttggtaat agtactttac aatgtcatca accgttttgc cttctttggc cataaaattc 3545101 gctccgtatt ggctcatccc cacaccgtgg ccaaatcctc tcgtcgtgac tgtaattgtg 3545161 tctccatttc gcttccattc aaaatcggcg gagttgagac ccaacttttc acgtatgtct 3545221 cttcctttca gcgtcttgcc gttaatgacg gcagttgcga cctggtggcc cggtgtctcg 3545281 ccggtaatct tccctactgc gctagatcca tccagcttga cgccaagctt ttgctgaaat 3545341 tctgccgctg taaaggtttt cgttgcctta tatttcggag actttttatc ccatgggctt 3545401 ttgacgcttt ttaaatatgg gatagcactt gtccaataag cttctgcatt ctctgtgtag 3545461 ccgttgcttg tggagaaaaa ggatgcttca atcggctggt tgttgtacgt taagattttg 3545521 ccttgcgtac tggctaccgc atctgtgatt ttcttcagtt ttgtctcata gcttgtgccc 3545581 cactgttttt tcagctccgc tttgctttta tacacctgga acatctgtgt atcatccacc 3545641 agtgagcctt taggagcttc taccgctgaa tttgacacca tcagtctgac aataaatgtt 3545701 ctggcggcaa gcgcctgggc tttcagcgct tcaggtttaa aggttgccgg catttcggag 3545761 gcgacgactc caatcacata ctcttcaagc ggaatgtttt ctacggattg atttgcggtt 3545821 cgatagacgg gaatagaaac aggtgatgct ttcaatgttt ctgctccttt cgatgctggt 3545881 ttcgtgctga ctgctgtctt ttctgattct acgctggccc ccgcttcctt attatgctgg 3545941 aatggtataa ccaagagtgt gggaaccaag agaatcaatg cacatagtac ggatagtgtg 3546001 attgcgaatt gtttcatatt cagctgcctc ctgctcggga ttcgactcta gtctagtcta 3546061 tgggcaggga caagctaata tgactctcgt tttggacaga aactttattt gtcatttacg 3546121 tattcttttt tgctattttg cgcataatga tgataataca caaaaaataa aaaaccagta 3546181 tgccagagtg acatactgat tttcaagtaa gtttatgcat ttaagtcaga aacgacttct 3546241 ttattctctt gctcagaagc agactcatca tttacacgtt cgatgtctgc gcccagagcg 3546301 gcaagcttct gatggaaatc aacgtaaccg cggtctaagt gcttcaattc agtaacacgt 3546361 gtgtgacctt cagccactaa ccccgcaaga atcagcgctg cacctgcacg caaatcagtc 3546421 gctgcaactt cagctccctg aagctgtaca ggaccgttaa tgatgacaga acgtccttca 3546481 atcttgatat caccattcat acggcggaat tcttccgcat gcataaaacg gttttcaaaa 3546541 acggtttctg taatcatgct tgtgccgctt gcacgaagca gaagcgccat catttgtgac 3546601 tgcatatcag tcgggaagcc cgggtgaggc attgttttga tgtcaatcgg tttaagctct 3546661 ttcgggccga tgacacgcag accttcacct tcatccttaa ttgttacacc catctcttcc 3546721 atttttgcaa ttaaagaggt gaggtgctca ggaaccgctc cttttactaa tacgtttcct 3546781 tcagtgattg cagcagcaac cataaatgtg cccgcttcaa tacggtcagg aataatatgg 3546841 tgttttacgc cgtgaagctt ttcgactcct tcaattttga tggtgccggt gccagctccg 3546901 cggatttttc cgcccatgcc gttgatatag tttgctaaat caacgatttc gggttctttt 3546961 gccacgtttt ccagcgttgt tgttccttca gctagagcgg ctgccataat caggttctct 3547021 gtagctccta cacttgggaa gtccagataa atttttgcgc cttgcagtcg gccttttact 3547081 tcagcttcaa tgaagccatt accgactttg atttctgcgc ccattgcttc aaaacctttt 3547141 aaatgctgat caatcggtct ggaaccaatt gcgcatccgc ccggaagtgc aactcttgca 3547201 tgacctgtac gcgcaagaag cggccccatg acaagcacag acgcacgcat tttacgaaca 3547261 tattcaaaag gtgcttcagt ttgcaaagcg tatgaagcat ttacagtcac ttcattattt 3547321 tcaaaatgca catctgctcc taaatgacgc aacacttcgt taattgtata tacatcggag 3547381 agcgtaggta catcacaaat tacgcttttt tcttcacttg ctaataaaga tgcagcgata 3547441 acaggtaaaa cggcattttt agcgccttca actttgactg tgccgtttaa cttctgaccg 3547501 ccgcggacga tgattttttc caaggtattc ccctccgcgt ccctaaattc tctatattaa 3547561 tattcagtcg taacgattgg tgtgccaacc gtaacggtat gttttccgcc cattcctgca 3547621 cttctaagtg caatttgcaa attcatttta tgtttcgagg tcataatgta ctcttcccac 3547681 tcatctgtaa acgcagaaat agaaacgaaa tttggctcaa ctacatgttc tactgatctt 3547741 gcttgaaatt catttaataa ctgatttgct tttttttgca aaacaatatt catattatca 3547801 tctaagtgac catttagaca agtaaaaata actacttttt cttggaatat cccaagtgtc 3547861 tcccgttcaa actgttcata tgtatcattc cagctatccg gtgtctctag actcatttgc 3547921 tcatataata aatacgaagt tggattgtgt tttttgaggg ttgtgacaag ctgcagtcta 3547981 aaagaagtac gatttttttt gtcagtatat gtgccaattg cctttatcat tttatcttcc 3548041 cgtgcaatca cccaatcata ttgacgatac tcttgtttta aacgttgcac tttttgataa 3548101 aattcttttt cggtcagtga caagttttgt tttgcatgca atgtccactt atctattgac 3548161 acatcttgac gttccatccc ctctgccatc tgtgctaacg gcgttaattc actcgcatga 3548221 atggtatgga aaacagcaat gacgaagctt aacatgacgg aaatgataat agcgtggctt 3548281 acttgttttt tcttcatgtt catctctccc ccttatcccc agttttaccg gaggcaagag 3548341 gcgccatacg taaaaatctt cgtcaaaact cgagctattc gcttcaaccc gcttctccca 3548401 accatttaat aatgttcaaa acctattaaa atagataggg aagctgctgt gaataattga 3548461 ggtaatctaa aaagaaattg gcaacggccg ttccaatggc gattgtcagc aaaatcatca 3548521 ggagtcttgc ctgcacgact ttgccttttt tgattaacgg atctatattg acggcttgca 3548581 acgcccacca agtcactgct ataaaaatca ggtgaacgac aatgccgatt gcagcctgct 3548641 gtcccaatac actcatctat tacactcctt tctctgcgtt catacccttt cttattatat 3548701 aagaagcaca gataaagatg atacatttta tacagaacgg aataatcagc caaatctagg 3548761 gctaatcccc gcttaaagtg cgattctttt acatggtata ctttattgga aaggagctgg 3548821 caaatgtgaa tcattctttt tttcagcctg aaaagcaata tggtgaggac ctgccaattt 3548881 ttgatcagga atgggaagca attgcattct attatgatta tagacagtca cagattgaag 3548941 aactgaatga attgtgtcag ttttttaaca tttctcttac ctatacgaga gaaagccttg 3549001 aagagcttga aaacctctat tttcaaagta tacaagaact tttgcttgct gattggaatc 3549061 ttcctattga agaattcgag aaaatgatca gtgtttatct tatagattgt gtgattgccc 3549121 gccatgaaga tgctgaatgg gttgtaaaac cttatcccta taaagacggc gcttatacac 3549181 ttggctttag aagacatcgc aaatcgtggc atacaatgaa tgcctgtgat ggtttatacc 3549241 tgcgtccaaa agaggatcgc ccgttgctgt cgctgtttga ttctcttgtg cgttcataaa 3549301 aaaatccttc tcataaagag aaggattttt tcttatttcc ctgctacatc caatctgttc 3549361 aaagcccgct gtaacgcaag ctcagcccga cgaatgtcag tatcatctga ttgagaattc 3549421 aaacgctcct gcgcccgctg gcgtgcagct tcagcgcgct ctttatcgat gccttccgct 3549481 gtctcggcag cctgggcaag gatggtgaca tgatcaggac ggacttctac aaaaccgccg 3549541 ctgacggcaa ccatttcagt ctgcccgtct tttttcagac ggacagcgcc gattttaaga 3549601 ggagccacgg ttggaatatg gcctggcaaa ataccgagat cgccgctttc ggctctcaca 3549661 ctcaccattt cgatatccgc atcgtatact gggccgtcgg gagtaacgat attgacttta 3549721 acggtcttca tgcttttacc ctcctaggac cagattaaac ttctacaccc atttcttttg 3549781 ctttctcaac aacttcttcg atacggccta caagacggaa tgcatcttct ggaagatggt 3549841 catatttacc ggctaagatt tctttgaagc cttgtaccgt ctcttttaca ggcacgtaag 3549901 aacctttttg tccagtgaac tgttcagcca cgtggaagtt ctgagaaagg aagaactgga 3549961 tacgacgtgc gcggtgaacg acaagtttgt cttcctcgcc taattcatcc ataccgagaa 3550021 tcgcaatgat atcctgaagc tctttgtaac gctgaagcgt tgactgtact tcacgcgcaa 3550081 ccgcatagtg ctcttctcca acaatttcag gagcaagggc gcgtgatgta gatgccaacg 3550141 gatcaaccgc agggtaaata cccatttcag ttaatttacg ctcaaggttt gttgtcgcat 3550201 ccaagtgagc gaacgttgtc gccggcgccg ggtcagtgta gtcatcggca ggcacgtaga 3550261 tcgcctggat agatgtaact gatccaacgt tcgtagacgt gatacgctct tggagctgac 3550321 ccatctcagt tgcaagcgtc ggctgataac caaccgctga aggcatacgg ccaagaaggg 3550381 ctgaaacctc tgaacccgct tgtgtgaaac ggaaaatgtt atcgatgaag aacagtacgt 3550441 cctgtccttg tacatcacgg aagtgctcag ccattgtaag gcctgtcaaa gcaacacgca 3550501 tacgtgcgcc cggcggctcg ttcatttgtc cgaataccat ggctgttttg ttgattacgc 3550561 cagagtcact catttcgtag aaaaggtcgt tcccttcacg agtacgctct cctacgccgg 3550621 cgaatacaga gataccgccg tgctcttgcg cgatgttgtt gattaattcc tggattaata 3550681 cggttttacc tacaccggca ccaccgaaca atccgatttt accgccctta atgtaaggag 3550741 caagcaaatc aacaacttta atacctgttt caagaatttc aacttctgtt gaaagctgat 3550801 cgaatgaagg cgcctgtctg tgaatcggat cctttttcgc atccgcagga accggctcat 3550861 tcaaatcaat attttctccg agaacgttaa atacacgtcc aagtgttaca tcaccaaccg 3550921 gtactgagat tggcgctcct gtatctacag cttccatacc gcgctgaaca ccatctgtag 3550981 atgccattgc gattgtacgg actgtatcat cacctaaatg aagagcgacc tcaagcgtta 3551041 aatcaatacc tacttcgttt tcacttgcag ctggctgtga aattttaatc gcattataaa 3551101 tttcaggcaa gtgaccgtct tcaaaacgca cgtcgacgac cggtcctaat acctggctaa 3551161 cgcgtccttt cttcatcgct atccctcctg acaaaatctt tctattctaa agcggctgct 3551221 ccgccgacaa tttccgtaat ttcttgtgtg atggctgctt ggcgagcgcg gttgtaagaa 3551281 agcgaaagtg aatcgataag ttccttcgcg ttgtctgtcg cgtttttcat cgccgtcatt 3551341 cttgcagcgt gctcacttgc tttactgtca agaagcgcac cgaagattaa gctttctgca 3551401 tattgaggaa gcaaaacctc cagaacctcc tcttcagatg gttcaaattc ataagacgcc 3551461 gttctttttc cgccgccgct gcccaaatca gataacggca gaagtttttt ctccgttact 3551521 tcttgagtaa tggcgctgac aaaatggtta taaacaaggt gcaattcatc aaacgcaccg 3551581 tctataaaca tttgaatcgt ttgacgggca agatctttaa tttctgtaaa cgttacttca 3551641 tctccaagtc ctgttaactc ggaaatgatc ggaatctccc gtttcttaaa gaaatcacgg 3551701 cccactcttc cgatggcaat caccgcatac tcatccttag actgatgacg ttcttgcatg 3551761 gcctgataag cactccgtaa aaccgaactg ttaaaagcgc cggcaagacc gcggtcagac 3551821 gtaatgacaa ggtatgccgt ttttttcact tctctgctga gaagcatcgg gtgcttcacg 3551881 ttgccggaaa ctcttccgac gtttgacaca acctcttgga ttttatccat atatggcaca 3551941 aatgattttg cattgttttc agcacgattc agcttagccg cagataccat ctgcatggct 3552001 tttgtaatct gacttgtttt tttcgttgac gtgatccttg acttaatatc gcgtaatgag 3552061 gccaaagatt tcaccacctt ttctcttcat ctgcgtaaaa agagagaaaa agagaacctt 3552121 tttctctcat cagcattcga gttagttgct tggtgcaaat gtgcgtttga agccttcgat 3552181 tgcagctttg aagtcttcat cagcaggaag gtttcctgtt ttcgcaattc cgtcaagcag 3552241 gtctttatgg ttttggtcaa ggtacatgta gtactcttct tcaaaacgtc tgatatccgc 3552301 cacaggaata tcatcgagat atccttttgt cagcgcataa agaatagcta cttgcttttc 3552361 aaccggaagc ggcttgttca gatcctgctt cagcacttca actgtacgcg caccgcggtt 3552421 cagttttgcc tgagtcgctt ggtcgaggtc agaaccgaat tgagcgaatg cttccagctc 3552481 acggtatgac gcaaggtcaa gacgcaaagt acctgatact tttttcatcg ctttgatttg 3552541 cgctgagccg ccgacacggg atacagacaa tccggcattg atcgctggac gtacgcctga 3552601 gaagaacaaa tcagattgca ggaagatctg tccgtcggtg atggaaatga cgttcgtcgg 3552661 aatataagca gagatatctc cggcttgtgt ttctacgaac ggcagagctg taattgatcc 3552721 tgcgcctttc gcgtcgctaa gctttgctgc acgctcaagc agacgggaat gaagatagaa 3552781 tacatcccca gggaacgctt cacggcctgg cggacggcga agaagcaagg acagctcacg 3552841 gtaagcggcc gcttgtttag aaagatcatc gtatacaaca agaacgtgct tgccgttgta 3552901 cataaattct tctgccattg taaccccagc atacggtgcc aggtacagaa gcggtgccgg 3552961 ctgtgacgca gacgccgtta caacaattgt ataatcaagc gcgccgtgtt tacgcaatgt 3553021 ttctactacg ccgcggactg ttgattcttt ttggccgatc gcaacatata cacagatcat 3553081 gtcttggtct ttttggttca ggatcgcatc gatcgcaaca gatgttttac ctgtttgacg 3553141 gtcaccgatg atcagctcac gctggccgcg gccgattgga atcagtgcat cgatcgcttt 3553201 gataccggtt tgaagcggtt catgaacgga tttacggtcc ataacgcctg gtgcagggct 3553261 ttcgatcgga cgagttttgc ttgtcagaat cgggcctagt ccgtcaaccg gctggcctag 3553321 cgggtttaca atacggccga ttaactcttc accaacagga acctccatga tgcggcctgt 3553381 tctttttact tcgtctccct cacggatctc actgaaaggt cctaagatga cgatacctac 3553441 gtttgattcc tcaaggtttt gagccatacc caaaacaccg tttgaaaatt cgacaagttc 3553501 accggccata cagttgtcaa ggccgtgcac acgtgcaata ccgtcaccga cttggatgac 3553561 tgtacctacg tcttgaactt caatatcaga ttgataattt tgtatttgct gttttatcag 3553621 cgtgctaatc tcttcagctt tgatgctcac ttaggtttca ccccttctat cgattttccc 3553681 cggctaattg acgttcaatg cgctgaagct tcccgcttac gctgccgtca taaatccggt 3553741 ttccaatgcg gactttaata ccgcctatta aatccgtctg cacttcattt ctgattctca 3553801 gtgaagcgac tccggctttt tttgcaaaca cttgtgataa tggtaacatt tctgcatccg 3553861 tcagcggttt cactgaatat acgattgcgt cttctgtttg acgggccaca tttgcgagtt 3553921 tgataaactc atctgtgagc tcagggacaa tcgcggcacg atggcggtca atcaaaagaa 3553981 aaatcgtatt gagtacggac tgtgacaaag agccaaatgc attttgaatc agctcttttt 3554041 tcttcgcagc cggcaccttc ggatggttca acacatcatt aagcgctttt tcattttgaa 3554101 atacttgttt tacaacaatt agctcttctt ctacttgatt cagctgagcg gactcattgg 3554161 ctatatcaaa aagagctgat gcatatcgtt tagagacagc tgatccactc atcggctttc 3554221 tcctacctct ttaagatagt cctggatcaa tttctcttgc gcttgttcat ccagttcttt 3554281 ttcgatcact ttcgacgcaa tcatgacaga aagagacgct acttgctcac ggagagcaga 3554341 aaccgcctgt tccttttcct tcacgatttc agttcttgct gcttctttca gacgttcaga 3554401 ttctgcacgt gcagcctgaa taatctcttc tttttgcttc tctcccagtt tctttgcgtt 3554461 ttcgataaga gtttgggatt cctgtcttgc ttcttttaaa agaacgcgct gctcttcaat 3554521 cagctgctgc gcttctttat ttttttcttc agcagacgta atttctccag cgatgtggtc 3554581 ttcacgctgt ttcattatgt ttaatagcgg ccctaaagcg tatttcttca gaagcgctaa 3554641 taagattaac atagctaaca gttggaacag gatatctccg ccgttaaacg acaatcctag 3554701 ttcaagtggt aattgagaca tctactacgg caactccctt ctgcaggttt ttctttgctg 3554761 atccagcagc cgcacttgtc tcttttcagc cggcaaggcg ggatgcttat cagacataaa 3554821 gcaatggcga aggttctctt ggaatgatct tcgccatttt tagttcatat aaggctttta 3554881 tgcttagcca aagaacgcta agaatgcgat aacgacagcg ataataggaa gggcttcaac 3554941 taatgcgata cccatgaaca taagagttct cagttcttta cctgcttccg gctgacgggc 3555001 aatcccctct accgtacgtg aaacaatcaa accgttacca atacctgcac caagtgcgcc 3555061 taaaccaatt gcaatcgcag ctgctattaa attcatgaaa aagttcctcc tttaaaatgt 3555121 tatccgtttg gatataatgt tttaatgatc atgactgatt ttatgagaca tgtacaccat 3555181 cgtcagcatt gtaaagataa atgcctggat agcaccaata aataaactga atgcttgcca 3555241 tgccagcatc ggcagaatgg caccgattgt accgacaaga ccgagagcca cgctttgcga 3555301 ataatggctt gttgctaatc ccgcaagcag gccgagaaga atctcaccgg cgaagatgtt 3555361 accatacagc cgcaaaccta gagtcagcgt attcgcaaac tcttcgatga ttttcatcgg 3555421 gagcatgaat ggaacaggtc ttaaatagtc tttggaatat tccttgagcc ctttcatctt 3555481 cacaccatag tagtgggtta aagcaacaac catcacggct agcgttaatg taatggcagg 3555541 atcggctgtc ggagacttcc accagagctc atgtccgatt gtaatagaga acggcagccc 3555601 cagcatattc gacacaaata tgtacatcag caatgtgaca ccaagtgcca agaagttagc 3555661 ccctgttttt aaatccattg tactgccaat aatattgcgg acgaaatcaa caatccattc 3555721 cataaagttc tgggcttttc cgggacggat cgaaagcgtt cttgtcgtca atatagcaat 3555781 caataaaaca atcacactcg ccacagtaat catcagaatg tttgtcagat taaaagtaag 3555841 acctagaaat tctatagttc tgtaaccatg attcaaaggg ttttcacctc tcttccattg 3555901 atgaacgttt aagctggata aaggaatcta tcataatgac agggtatatt gtcattaatc 3555961 caataactgt acttgccata tgaaagtatt cgggattttt ataggcaaca gccacagcaa 3556021 gaatcgcatt gcaccaccgc gctgcgctcc cgagagatcg tatggacttt cctttctcta 3556081 cagctctgtc aaaagcattc attcttctga cgagcagtaa aaaattaaac aaactgaaaa 3556141 cagttcccag aataaggcct aaaaaaacgg ttttatacgc tgttaaacca taacccagta 3556201 catacactgc caaaatgaac aataaatatt tgcgttgtct gctaaatgta agcttgggat 3556261 cgtccatcaa ttatctgtct cctgatgaaa aaataatgta tagcttggat acggcaaaaa 3556321 tcagcggtta acccttagta gaagaccttt tttgaccggc aaaacgggcc tgttcgaaaa 3556381 aatcattcat ccgcaagcct tgcagggatg ctgtttcatt cgcttaaata aatcctcata 3556441 atacgggttt gctgagagga tttacattga ggatgaggac tataatgaaa gctatgaaaa 3556501 ccttctcata ataccctcgt ttagcataca atagccccta acatgtgtca atctgtttaa 3556561 agttaaaaaa ctttttatac tttacgtctc cacagaatgt tcacattttc acctataatt 3556621 gtatacagat tcaccgaata gcaaaaaact ggataaaaaa atgaaacccc cttttgggga 3556681 tttcattttt tattttgttc caaacatgcg gtcacccgca tctccgagac ctggaacaat 3556741 atatcctttt tcatttaatt tttcatctag cgccgcaatg taaatatcaa cgtccgaatg 3556801 atgcttctgc aattcttcca caccctccgg cgctgctaca agacacatga aacggatatt 3556861 tttcgcaccg cgttttttaa ggctgtgaat ggcttcaact gcggaaccgc ctgtagcgag 3556921 catcgggtca accacgatga attcacgctc ttccacatca gaaggaagct tgacatagta 3556981 ttccacgggt tttaaggttt ctggatcacg gtaaaggccg acatgtccca cttttgccgc 3557041 aggaatcagc tttaaaatgc cgtcaaccat tcccaatcct gctctgagga taggaaccac 3557101 tccgagtttt ttccctgaga tgactttcga tttcgcagcc tgaaccggtg tattgatatc 3557161 cacttcttcc agaggaagat cgcgggtaat ttcaaatgcc atgagtgtag ccacttcatc 3557221 tactaactct ctaaaatcct tcgtacctgt attttcattc cgtatatatg tcagcttgtg 3557281 ctgaattaaa ggatgatcaa atacataaac ctttcccata ctgtgtttca gctccttttt 3557341 tattgtccca tcaacaatta cacacttcta ttgattctac aaaaaaagac attgagtttc 3557401 aagaacatcg tcaaaaaacc cgccgggcat aagcccaagc gggttttagg atcttaataa 3557461 tctaattctt tatataaagg aaatttatca gtcagagcag ctacacgctg tcttgcttct 3557521 tcaagttttc cttcatcttc gtggtttttc aatgcaagcg caatgatagc accgacttct 3557581 tctaatgcgt ctccgtcaaa accgcggctg gttacagcag ctgtaccaag acggatgccg 3557641 cttgttacga aaggtttttc aggatcatat ggaatcgcgt ttttgttaga cgtaatacca 3557701 atttcatcaa gtacatgctc cgcaacctta ccagtcagtc cgagcgaacg aaggtcaaca 3557761 aggataaggt ggttgtctgt tccgcctgaa acgagctgga tgccctcttt cgttaaggct 3557821 tcagccagac gtttcgcgtt tgaaatgacg ttttgtgcat atgttttgaa atcgtcctgc 3557881 aatacttcac cgaatgaaac agcttttgcg gcaataacgt gcatcagagg gccgccttga 3557941 attccaggga agatcgattt atcaattttc ttgccaaact cttcacggca aaggatcata 3558001 ccgccgcgag gaccgcgaag tgttttatgt gttgttgttg taacgaaatc agcgtaagga 3558061 accgggtttg gatgaaggcc tgccgcaaca agtcctgcga tatgtgccat atccaccatg 3558121 aagtaagcgc cgacttcatc agcaatttca cggaatttct taaagtcgat tgtacgagga 3558181 tacgcacttg ctcctgctac gataagcttc ggtttatgag cgagggcttt ttcacgcacg 3558241 tcatcgtaat caatatattg agtttcttta tctacgccgt actcaacaaa gttatattga 3558301 acaccgctga agttgactgg gcttccgtgt gttaaatggc cgccgtggga gaggttcatc 3558361 ccaagtacag tatcgccttg ctccaaaatc gtgaagtaca ctgccatgtt tgcttgtgcg 3558421 cctgaatgag gctgaacgtt tacatgctcc gctccaaaga tttccttcgc gcggtcacgg 3558481 gcgatatctt caacgacatc gacgtgctcg catccgccgt agtagcgttt gcccggatat 3558541 ccttctgcgt acttatttgt caaaacagat ccttgtgctt ccataaccgc ttcacttaca 3558601 aagttctcag aagcaatcaa ttcgatctta gtctgttggc gttcacgctc atttttaatg 3558661 gcgttaaaca cttgttcgtc ttgcgcaggt aaatgtttca tcagcgagat cctctcctat 3558721 ccgtatcctg ttctttgttt ttaccatcac tattgtacat ggtttttaag gccgatgtaa 3558781 aagattattt ttaaaaaatc taaattttta ttggtaaaaa cgaatattaa taacttaaat 3558841 ttaatttaaa gttcggaatt tatttcacta tcttaaaata aaagaaaaga ctggctatgc 3558901 agtcctttca ttcgcactca taaaccgccc gcactccgcc gattagtttc ggccgtgtac 3558961 gcgccaatgt cacatgagct gaaccgaggc tgttttgaga gacacgcaca gggacagcca 3559021 ccggtttcag atgcatgccg ataaacgtat cgcctatatc aattccggcg tcagcctgaa 3559081 tggtttcaac aagaacagga gacttcatct gcttaaacgc ataagacgcc atcgctccgc 3559141 ccgcttttgg aacgggcacg gcagaaacgg ttggaagcct gaacagcttg gctgtttctg 3559201 cttcgacgac aagcgctctg tttaaatgct cgcagcattg aaacgccaga tggattcccg 3559261 ttttttcccg gagctcagca agtccgctgt agatgctttc agcgatatct acactgcccg 3559321 atgtgccgat ccggctgccg gccacttcgc tcgtgctgca tccaaggacg aagagctgat 3559381 cttgtttcaa ttccgcttgg tcctgaaact cagacagcat cgtcttccac gtttgtttca 3559441 actcattcat taaacagcac ccctacaggt ttttctcttc ataatcggag atttttccaa 3559501 tacgcgtttg gtgtcttccc ccggtaaact cagtagtcag ccagattttt gcgatttccc 3559561 gagccaaacc aggtccgatc acccgttcac ccatcgcaag gatgtttgtg tcattatgct 3559621 ccctcgtcgc cttcgcgctg aaggtatcgt gcgccagcgc gcagcgaatc ccttttactt 3559681 tattagcgga aatgctcatg ccgatgcctg tcccgcaaat taaaatgcct ctgtcaactt 3559741 cgccgctaac cactttttcg gccaccggaa aagcataatc cggataatcg acagagccgc 3559801 tgccgcagtc acagcccata tcaatatatt caatttgcaa ttcgtccatt aactctttga 3559861 tttcatttcg aatgtgaacg ccgccatgat ccgatgcaat ggctactttc atctgctttt 3559921 cctcccagcg tgtgtgatgc ggcccgcccg ctttattgac cgcgcagcct gtccgctctt 3559981 tgattcacac catatgatgt gcttttcact atattctact ccttcacgca ggatttgcaa 3560041 atgacctgtt tgcagatttt ctgacaactt atctacggtc ttttttcagc tgttttgcca 3560101 gctgccgaag aagctcttca agctcatctc gcgtttgttt atagatgtca attgagccgc 3560161 cgaacggatc gaggacatca ccatggctgc ctgtgacata ttcttttaac gtaaacactt 3560221 tatcacgata acgtccaaat tggctggcaa tgatctgttt gtgctgatgg gtcatagcca 3560281 gaaccaaatc agccgattcc ataagttctt cagttaatgg agaagacaca tgattaaggg 3560341 caatgtgttt ttcaaacagc gcttcgactg catgaggcgt cgctttccca ttaggtgaag 3560401 caaacacgcc tgccgagcgg acattgacat tcagcccttc cctttctgca attgatttaa 3560461 aaagcgcctc agccattggg ctgcggcacg tatttccagt acagacaaaa ataatatcca 3560521 tgtcagtcac cccttatttt tctctattat atatgaagaa aaaagaaacg gcgacttcgt 3560581 ttcttttatt ggtatattaa attggcaaaa gcagctttaa tccaaacacg attaatatga 3560641 tgcccccgag cgcttcgctg tatgtgccaa gccatgactg cacttgtttt ccgaccagca 3560701 ggcccagcca tgtcaacatc atgctgaaca gcccgaacag ggtaattgtg aggagcggat 3560761 gcgagccgta tatccccaag ctcaagccga cggaaaagct gtcaaggctg acgccgatgg 3560821 caaacagcaa taagcccggc cctgccggtg acatgaatcg ttcttctgac tgtttaaaag 3560881 aggccataag catttgaacc ccaagaacaa aaagcagcgc cccaccgata taaaccgcta 3560941 acacgccgag gagccctgac agcatgttac cggccgccat ccctgcgaga ggcatgatga 3561001 cgtgaaagag gccgatgatg aaaccaatat agaatatctg cttctttcta agtttgacca 3561061 tgcccattcc aaggccgaca gaaaaagcat ccatccctaa agcaaacgcc atgatgctta 3561121 atgtaatcag ttcgcctata aacaaatccg acatacataa ataaccccct tggacacgcc 3561181 ccgctttttt agcctatgcg tgtccaaaaa gggttagaac atctgactgc tttcagcgaa 3561241 tcactcttcc tccggcggct ttcatcagcc tgttcataat agcaagaccg acacctgtat 3561301 ccggaaagga ttccgctata atgaaatcca ccttattctc atcaaagctg cgcaaagcat 3561361 catacagccc tgccgcaaca gtctcaagct gagcccgtct tccgcagctc ttcacataat 3561421 cagcggaata aacgcccgct ttttcttctg tcgtcaggac accgacccgt cttccaccct 3561481 gttgatattc ttgaatgagg tgctgaatgc gctctgggct gccttcgcaa atggcaagag 3561541 gcgctgtcgg cgcataatgt gtatatttca tccctggaga aatcggcttc tcgttttggt 3561601 cgctgagccc tttatccaca tggatcggcc cgatcaccgc ttcaatttgt tccttcgtaa 3561661 tgccgccagg acgcaagaga acagggatgt cgtccgcaca tgaaagcaca gttgattcga 3561721 ccccgattcc ggtagggcct ccatccacaa taccggctat gcggccatcc aagtcgtgag 3561781 ccacatgctc cgcttttgtg ggacttggct tgcctgatag attggcgctc ggtgctgcaa 3561841 tcggcagtcc cgattcgcga atcaatgcaa gggcaagcgg atgatccggc attctaatgg 3561901 caaccgtttc aagacctgcc gttacacgag gtgaaagcgc atcaggtttg caaggcagaa 3561961 tgagcgtaag tgctcccggc caaaaccgtt tcatcaatgt tttcgccttt tccggcgccg 3562021 ggcccgttaa atcctcaagc tggctgatat ccgcaatgtg gacaatcagg ggattatcgc 3562081 tcggccgccc tttcgcctca tatatttttt tgacggcatc cgtatttttt gcgtttgcgc 3562141 ctaggccata tactgtttct gtcggaaagg caacgacctc attttctcgg agcaaagcgg 3562201 ctgcttgtgc aatttgtgga tcatttgtgg ataactcgtc agttacatcc acaaaccatc 3562261 ttttcgtttt catttctgac caaactcctt attcacaaca ataaaacgat tgttttacgc 3562321 gtgtaatcct tttgaaagta taaaagatgt cctgtaataa aacaagcgtt atccacaaat 3562381 tgtggacaac gctaataaag aagtggataa gtatgtgtat aaactgcact tatccagacg 3562441 cttttttcat caaaacggct ccttctgttt gccgcgattc acagaagtga tcagaagaaa 3562501 acagctcctc cggtacactc tcagctcttt caaaacccat ggccgtcaga aagtccgcag 3562561 aggaatgctg atttgctact aggtacacgg ttttgatctg atgcttttcg cacagcacct 3562621 ccatgctttg aaaaagcgtg acgatgtggc cttggtgaag cttgtccgat atgacaagtg 3562681 atcgcagcag cccctggtca cagcttattt tttcaatacc gaggcatccg gcaatgtttt 3562741 tctcactgtc ctccagcata agaaattgag tgaagccttc tttcacgcct tcatagctgg 3562801 tttttgcctg ttttaaaaat gcctcgagca catctccgtc tttttccctt gccacccgca 3562861 gttgataaaa catccgttca ccccgttttt gcgttctttc ttccaatcta tgaggcaaat 3562921 ctatttttag accagatgat taggaaaaaa ggtcggaaat ccattcgact aaaaagaatt 3562981 tcacttctgt gccgtcttct ttttcttcgt tctcttcttt tttggctttt tccgctttag 3563041 cggttacgtc ctcaagcact ttttcagtct gcttttttga ggcttcttta tcttcttgtt 3563101 ctttgacggc ttccccgtta gaaaaatcaa gaaagcagag gggcgggaac agcacacacc 3563161 accagttggc gccgtctccg tttccaagcg taatcaaaat cgcttcatac tcaccagcgg 3563221 gatataccat gttgccgtaa agctttgtcg gaaacgagat tttgtcaaaa tcaacggata 3563281 tcgactgatt cgctccttct ttctccattg tttcctttgc aattgctttg atttcaggca 3563341 gctttgaacg aatcacgcga cgcgcttctt caatagaagt aatatccttt acccaagttg 3563401 tgatttcttt attcaccgcg tctcttatat gacgttttaa ttgctggtct tgatcactat 3563461 cgctgtttgc cagtattctc aaacgaatcg cctgatcagg tatgaccacc ggctgatttt 3563521 ccgatttttg tgccgtctct tcttttgcca gccctacgag cgctccggat aataaaagaa 3563581 agatatatat acaaatgatt actgtttttt tcatcggtcc ccaccgttcc tctccgtgct 3563641 ttgtttctag ccctattatg gacaaggaga gcctgggata aacgtgcagg gtgaaaaaaa 3563701 tctagcaagc tgttaatctt atttatggta cgatagtgtt ttaggaggtt taagatgaaa 3563761 tacaattata cagtgctgtt atcagcattc acgatgtccg ttctttattc agtaatttat 3563821 attcattcat ttatcattgc cgctctcatc acaatggcat tttattttct gtttccttat 3563881 ttgatcttcg cactgccgct tcaaatcatg atgaataaaa agccgaaacg tttcagccct 3563941 ttgtatctgc tgtattacct tgccgctgct tttattgcca acgcgatcat tttcggcatg 3564001 cttcagcctt cgggacaatc tctgtttcaa aatacagcct tttatctttt cgctgtatta 3564061 acagctctta tctattggat atgggattct gttttactgc aaaaaaagga agcctaagag 3564121 gcttcctttt ttattaaaac aaaatcgtca gtaaataaca tagaatggaa ggtatcgccg 3564181 caacaaagaa agcggccgcc attttcatgc gagatgtacg gccttctttg gtttctgaat 3564241 ggtagtttgc ccgctgatcg cttccgctta cagccaaacc cgatgtaatg atcgcgagcc 3564301 ccactaaaac gagagacgca acgccaaaaa tcgcttcata tgaaagagcc tgcggaaaaa 3564361 tggtgccaat catgctctca atcgcaatga gcaggattcc tgctgtcagg gcctttttca 3564421 tgtttacatc ccctttgctg gtgttaaaca gcttgatcca ttcactcgcc agcaagctgc 3564481 ttatttattt ttatgaatca gagcgcatat ggttctgtct tttccattaa tatctttcag 3564541 cacttccact tccgccccct taaacgcctt gaggatcagg tctttgaccg ccgctccctg 3564601 tttccagccg atttcaaaaa cgacaaatac tttatccttc ataacaagcg gaatgtcttc 3564661 cataaaccgc ttataaaatt tcagcccgtc tccgccatcg gtgagtgcgt gcagcggctc 3564721 atgaaaacgg acaatttccg ataaatcagc catttcttcc tctgaaatat atggcgggtt 3564781 tgagacaatg atatccgctt tttttcccgc cttaataaaa ggctcaagca gatcgccctg 3564841 ataaaagcgc acattcgctc cgagtttttc tgcattggca gaggcgactt gcagcgcctc 3564901 tttcgaaata tcgaccgccg acacagaaaa gctttggttt tcaagcgcaa gcgtgacggc 3564961 tattgcgccg ctccctgtac caacgtcaac aacttcgagc ttgccgtctt cagaaaaaac 3565021 actccgatat ttttcaagca aatgaaagac aacttcttca gtttccggcc gcgggatcag 3565081 cacatcatca ttcaccataa attcccgtcc ataaaaaaac tcttttccta taatgtattg 3565141 aaccggcacg ccctctttat gcatctcaac gtgacgctta aagcgataca gttcgtcttc 3565201 accaatcggt tcctgtaagc ttgcgagcag cttgcttctc tccattccgg tatcataaag 3565261 caataggagc tcggccgcat tttcttctct tcccgcttcg gttaaataag aagaagccca 3565321 tttcagggct tcgaatatcg tcttcatctt aaccttccga ctgctgaagc ttgcttgcct 3565381 gatcttcaac aatcagcgct tcaaccactt cgtcaagttt tccttcaaga atctgatcaa 3565441 gcttttgaat cgtcaaaccg attctgtgat ccgtcacacg gttttgcggg aagttgtatg 3565501 tgcggatacg ttcagagcgg tcaccagatc cgactgctga tttccgtgtt tgatcatatt 3565561 cagcctgggc ttcctgctga aatttatcat agattctggc acggagaacc ttcattgctt 3565621 tttctttgtt cttaatttga gatttttcat cctggcatga tacaacaaca cctgtcggca 3565681 agtgagtcag acgaaccgca gacattgttg tgttaacgct ttgtccgccc ggtccgcttg 3565741 aagcaaatgt atcgacacgg atatccttct catggatgtc gacctctacc tcttctgcct 3565801 caggaagaca tgccactgtt gcagtggatg tatggatgcg tccgcctgat tctgtttccg 3565861 gaacacgctg tacgcggtgg gcgccgtttt catatttgag tttagaatac gcgccgcttc 3565921 ctgtaatcat aaagatgatc tctttgtagc cgcccgttcc ggttacattc gcttccatga 3565981 cctctgtttt ccagccctga agctcagcat aacgggaata cattctgtac agattgcccg 3566041 cgaataaagc ggcttcctcg cctcccgcag ccccgcggat ctccatgata acgtttttgt 3566101 cgtcattagg atctttcggg atcaggagca ccttcagccg ttctgacagt gtttccgttt 3566161 ccttctgaag ttcagaaatc tcttccttca ccatgtcgcg catctcagca tccagcttct 3566221 cttcaagcat cgcttttgca tcagccagct gttctgacgc atctctgtat tgtctatata 3566281 cgtcaactgt ttcttgtata tcagattgct cttttgaata ttctcttagc tttttcggat 3566341 cgttgactac ttctggatcg ctcaaaagct catttaattt ctcgtatcgt tcttcaattg 3566401 attttaaacg gtctaacacg gtcttcacct ctgttttcct gtgcgtaaca ttctcattat 3566461 agtatagtga ttaaccccag tcaaaagcat ttcaatccca gctggaaaag ctccctctgc 3566521 tatactggaa ttcgaggagg gatgatgttg ctgaaatcca tacatcatat tgcaatcata 3566581 tgttcagatt acgaaaagtc gaaagctttc tacgtacata agcttggttt tcaggtgatt 3566641 caagaaacgt accgcgaaga gcgcggctcc tataagcttg atttgtcgct taacggctcg 3566701 tatgtcattg agctgttctc gtttcccgat ccgcccgaac gacaaacccg gcctgaagcc 3566761 gcaggcctgc gccacctcgc ctttacagtc ggcagcttgg ataaagctgt tcaagagctt 3566821 catgaaaaag gaatcgaaac agagccaatc agaacagatc cgctgaccgg caagcgtttc 3566881 accttctttt ttgatcctga ccagcttcca ttagaactgt atgaacaata acagtttttg 3566941 aagaaaaaaa ggagataccc actttctttg ccgaatcttt tcttgttttg tctaacggga 3567001 agggaaccgc attctatggt cgaataccta gcttaaaagg aggtatggga tcatgaatac 3567061 aaatatggta gcaagtgaac tcggcgtctc cgcaaagacg gtgcagcggt gggtgaagca 3567121 gctgaatctt ccggccgaac gcaatgagct cggacactat tcgttcacgg cagaagacgt 3567181 gaaggttcta aaatccgttc aaaaacaaat ctctgaaggc acggcgattc aggatattca 3567241 tctgccgaaa agcgctaaaa agcgcacagg cttccttgtc caaaaaacaa gtagcgacac 3567301 agaacgaaga atcgagcagc ttgaacaaaa gctggacacc cttttacagc aaaggcagga 3567361 cgaaagcgaa ttgatggcaa ggatgtcgga actggaacgc cagctgaaac aaaaagccga 3567421 tgaaggtgta tcttaccagc tgcttcagca ccgcagagaa atcgatgata ttcttgcaga 3567481 tctgcaatca ctgacctcac aaatgaaaga attcaccgct cattcgatcc ccgagactgc 3567541 tgctgcttct gaaaaaacca aaacaagaaa aaaaccgctg ctgtcactgt tcaaatttca 3567601 aacctaaagc aaaaagctcc cttaaaggga gctttttttg ttacgcagta agcgcgataa 3567661 tgattggaag tgaaatcaat gacagaatcg cactgaccac aaacgcagtt gcagtttctt 3567721 cttcttgttt ctcgaaacga gtcgcaatca tggctgcaac ggcagaacca gggaatgcaa 3567781 caagaaggat tgcttttgtt gtttggtcag ctggaagtcc gatagcaaga gcaatcagga 3567841 acattaacgc aggctgaacc gcaactttta gtaacgcaat accgatagcc ggcatactga 3567901 gtttaatttt acgaatacca acggtaacac caacagcgaa gagagcaaca ccagatgttg 3567961 tgcttccaag ctgatcaagc attttaacac ccagctcagg aagagtgaaa ttgaaaacca 3568021 gcaccaagat catactgatt aacggagcag ctgcaagcgg ctcacaaaga ccatgcagga 3568081 ttgattttcc tgtcatcttc cagaagctgt cgccactctc ttcgtttttc ttagaagact 3568141 caccaacagt agcgataatg atcgcgagcg gatcaagaat cgcgttaacc acgatacctg 3568201 tgaccgcgat cggaatcgca acttcattcg ctccgaataa gcttcccaat accgggatac 3568261 ccataaatgc gaatgtcggc tgtgcagagt tcaaagaaaa tacagatgag ttcgttaaat 3568321 catacttgaa tataaatctg caaaccaaaa gaatgatgat atagaaacca acaatcccaa 3568381 taattaaaga aatcattaaa ggtacttgtg ataaaaattc acttctggaa gttgtcaaaa 3568441 taccagcgat aaagtgagct ggaagtgcgt atttcgttac taacgtactt accccttttg 3568501 ccgacttggc atcataactt ccaaaatgtc ctgcaaacca acccagcacg ataacaaaga 3568561 agatcggcgc caggaggatt aagatatcta agatgctcaa aatattctcc tccaaatcct 3568621 atgtccgtat actttagctt tacaaaaagc tttccctcgg acagaaaaat ttactcgcta 3568681 attatttcgc gatgactttt ttgtattcag gtgtccacat tgcatcaagt accgcttgtt 3568741 tcacatcttc aggctgacga tttgccacgc cgtctttaat tgctgcttca gcaacggcaa 3568801 tcgcaacttg gatagaaacc tcttgaagct tatcaatgct tggaagcaat cctgctccag 3568861 gtgtttcaag atcaaccatt tcagcaatcg catcagcagt tgcagcaaac atagcaggtg 3568921 taatgatacg cgcttcagct acaattgaac caagtccaag accagggaac gcgaatgcgt 3568981 tgttagattg tccgatttca taagaaacac cgttgtattc tacattgtca aatgggcttc 3569041 ctgttgcaat aagcactttt ccgtcagtcc atttgaacag atcttcagga acagcttcag 3569101 caaggtgagt cgggttagac atcggcatga taaccggacg gtctacgtga gatgccattt 3569161 cttttacaat ttcctctgtg aatgcacctg aaacccctga agtaccaatc aagattgttg 3569221 gtttcgcttg acgaacaact tcatcgaatg gaatttgacc tttttcatcg cgcttccagt 3569281 ctttcacttc atccgcattg cgaaggtaag gtttttggaa atcaaggatg ccttcgatgt 3569341 cttcagtcag caagcctctg taatcaagtg tgtagaaacg tttgttagct tcttcttcag 3569401 ataatccggc tagcaccatt gtgtcacgga tttggtcagc aataccgata ccagcagaac 3569461 cagcaccgaa gataacaaca cgctgatctt taatagaagc gccggttttc ttcatagcgg 3569521 caagcacacc tgcaagtgta atcgcgccag taccttgaat atcatcatta aatgtcagga 3569581 tttcatgatt gtattttttc atgatgttgc gtgcattttt gttgccaagg tcttcccagt 3569641 gaagaagcgc tttagggaag aatttcaatg cagcttttac ataagcgtca atgaaagctt 3569701 cgtagcgttc accttgaaca cgttcatgct tgttaccaat atataaagga tcgtttagaa 3569761 gtttttcgtt gttcgtaccg acatcaagca caaccgggat aacacggcta gggtcaatac 3569821 cagctgcagc agtgtagaca gccaatttac cgattgcaat attaataccg cctacacccc 3569881 agtcaccgat accgagaatg ctttcggagt cagtagcaac gataagatca atatcgcctg 3569941 ctgtcgcatg aaggttttca aacgcttttt caataccgtc aatgttatcg attgacaagt 3570001 agattccttg aggtcttcta tattcatggc tgtattcctg aatcgcttca ccaactgttg 3570061 gcgtgtacac aacaggaagc atttcgcgaa gatggttttt cagcaattta tagaaaagaa 3570121 cttcgttacg gtttgcaaga tcacttaagt aaacattttg acgaaggcgg tcaggctgcg 3570181 cttggaattg ctcgtacgcg cgttgtgctt gttgatcaag agaaagtaca gttggcggca 3570241 gaagcccttc taagccgagt tcttgtcttt cttctagtga aaaagcaacg cctttattta 3570301 aagtaggaat agataaaact tcttttcctc taagagttgt ttctaagtgg ccttctttcg 3570361 ttttttttat gttattcaag caaatctcct tctttcttga aatagttaac caagttaagt 3570421 aataacccat ctaaaatatg accgatcatg atctttatgc gactttgtga caattattcg 3570481 aacaatgtct caaaactatt tacattacgt aagctattgt atgcctgtca aaatcaaaat 3570541 tcaagagaag aaaattactt aattttttaa tatacttatt taaatttttt aattgaatat 3570601 tatcagaata taaaaaaaac accggtgttt ttagccggtg cattctatct ttatacccat 3570661 gttttggact attttttaga tttacctggg acttcgtgat gatgtctgca tcttgcttca 3570721 tatgattcag ctgcaccaac caaaatgacc ggatcatcgt aagaagcagg tttgccgtca 3570781 atgaggcgct gtgttctgct cgccggtgat ccgcaaacag aacagacggc ttgcagcttt 3570841 gtcacacttt ccgcaatcgc catgatattc gggacgacac cgaacggctc tcccctaaaa 3570901 tccatatcaa ggcctgctgc tatcacacgg tagcctttat cggcaagaga tgataaaacc 3570961 tcaacaattt cctgatcaaa aaactgcact tcatcaaccg caaccacatc tgtactttca 3571021 ctgatgtgat cccaaatgtc cgcagcagac gaaatggcat agctcgtcat cgatgttcca 3571081 ttatgggaga caacagcagc ttcgctgtat cggttatcaa ttacaggctt aaataccctg 3571141 acttcctgct tggcataagt tgctctcttc actcttctga tcagctcttc agatttcccc 3571201 gagaacatgc tgccgcaaat cagctcaagc cacccgcttt gtttcattat gtacataggc 3571261 ttcgctcccc tctctctgcc agctgtgttt tagacaatat aaaaaacagg caagactgct 3571321 gcttgcctgt tgagaaatct attattactt aagaccgtat tttttgttaa agcgatcaac 3571381 acgaccatca gcagaagcga atttttgacg gccagtgtag aatgggtggc attcagagca 3571441 aatctcaacg cgtacctctt cttttactga gcctgtttca aattcatttc cgcaagcgca 3571501 tttaactgtt gcttttttga aattaggatg aattcctgct ttcattgtat ccatctcctt 3571561 ccgccctgaa tcccgtgtgg aaacagagtt attatttcgg agcattgtcc gaaacgcata 3571621 tgagaaaatt atatcagtga tttacttctt ttgcaaatac aatttacctt cttgcagatg 3571681 atagatttgc ctgtttccat tcttgattga gaatatcgaa aaattcctgg tttgttttgg 3571741 tttttttcat ttttctcatg aacttttctg cgaaatcagg tgaatcagac atcgttttgc 3571801 ggatagacca taaacgatca agatgctctt taggcacaag cagctcttct ttgcgcgttc 3571861 ctgaacggcg gatatcgatg gcagggaaga tgcggcgctc ggcaagagag cggtcaagat 3571921 ggagctccat gttgcctgtt cccttgaatt cttcataaat gacatcatcc atacgtgaac 3571981 ctgtatcgac cagagccgta gcaaggatgg ttaagctgcc gccctcttcg atatttctcg 3572041 cagccccaaa gaagcgtttc ggacggtgga acgccgctgg gtcaatcccc ccggaaagcg 3572101 ttcttccact tggcggaatc actaagttgt aggcgcgggc aagacgtgtg atgctgtcca 3572161 tcaggataat gacgtctttt ttgtgttcca cgagacgcat cgcacgttca agcacaagct 3572221 cggccacttt gatatggttt tccggcactt catcaaacgt tgagctgacg acatccccag 3572281 ctacagagcg ctcgatatcg gttacttcct caggtctttc gtcaattaaa agcacgatca 3572341 gctctgcttc aggctggttc gctgtaatgc tgttggcaat ttccttcagc aacatcgttt 3572401 ttccggcttt cggcggcgca acaatcaatc cgcgctgccc aaatccaacc ggcgccatca 3572461 tgtccataat tcttgtagac aagaagttcg gctttgtttc aagcaccatt tgacgatccg 3572521 gataaagtgg cgtaagagcc gggaaatgca cacgctcttt tgcagattcg ggatcatccc 3572581 catttactgc ttcaacgtgc aaaagtccat agtaacgctc attttctttt ggcgggcgaa 3572641 ccttgccaga tactttgtct ccgttccgca aatcgaaacg gcggatttgt gaagctgaga 3572701 tgtaaatgtc ttctgagctt ggagagtagt tgatcggtct caggaatccg aaaccttcag 3572761 actggatgat ctcgagaacg ccttccataa acagcagatc ttcctgttct gcattcgctt 3572821 tcagaatggc gaaaatgagt tctttttttg tcagtttgct gtaataggag attttataat 3572881 gtcttgcaag ttcataaagc tctttcaatt tcatattttc caaagaggaa atagatacgt 3572941 ctttcataaa aacaccacgc ttttcatagt caatatctta ctctgaacat gtcatctgct 3573001 gcttttgcac aacatccgcc aaagcacatt ctttttttaa cataaaggaa cttctatcgg 3573061 taacacttcc acccatgatc ggcgcttttg ttaaaaggat tgtcttaatg agttttgaag 3573121 gaagcgagga caaaaacatg agaagatcaa tacttatatc gtctgtatgc ggtagaaatt 3573181 gaaactttcc tagtgcttaa aagaaggtat tacgcagtaa aattcgcagc actctttatt 3573241 tttaccttat ttcaaaaaat tattcaactg aaataaggtt ttgacacgga attgatagag 3573301 ttgacgcttt tctgcaaaag ttaaagcggg ctcacacccg ctttttctgt ttgttatgga 3573361 cggattacaa gatttggttt ctttttcaag ctgtgtctgc cgtcaacgaa acgaacagtg 3573421 cccgattttg cacggataac taagctttca gttgtaccga cagagccttt gaattgaact 3573481 ccttttaaca gctcgccgtc agtaacccct gtagctgcaa aaatcgcgtc atcacccttc 3573541 acaaggtctt ccatgcgaag cactttgctt aaatcaaggc ccattttgtg acagcgagtg 3573601 atttcttctt cgctttgcgg aagaagttta ccaatgattt ctccgccgag tgcttttagc 3573661 gcaacagcgg aaagcacacc ctcaggagcg ccgcctgatc cgaacaggat atcaacgccc 3573721 gtgtggtcga aagccgtgtt gatggcgcct gcgacatcgc cgtcattgat caatttgatt 3573781 ctggcgccgg cctcacgaag ctcggaaatg atttttgcgt gtctttcacg gtttaaaatt 3573841 gtggcaacga cgtcctcaac gtccttgttt ttcgcttttg ccaccgcttt aaggttgtca 3573901 atgacaggtg cttcgatgtc aatgcagccc accgcttccg gaccgactgc gattttttgc 3573961 atatacatgt caggagcatt cagaagcgtg ccatggtctg cgaccgcgat aaccgtcagc 3574021 gcgttccagc cgccgcttgc taagatgttt gtgccttcaa gagggtcaac tgcgacatca 3574081 acgcgagggc cgtacccgtt tccgagtttt tccccgatat acagcattgg cgcttcgtcc 3574141 atttcccctt caccgattac aacggtccct ttcatcggca ctgtatcaaa aacgtctctc 3574201 attgcacttg ttgccgcttc atcagcctca tctttttttc cccggcccat ccatcttgct 3574261 gatgccaatg ccgcagcttc tgtcacacgt accaattcca ttgataaact tctttccatt 3574321 tcaacacgat ctcctctcac aagaaaccat tatgaatttt gaagctgttc tatttcttcg 3574381 tcagtcattc tttcacgcca aattgtcgct ccaagcccct caagcttctt ctcaaggctg 3574441 ctgtatcctc ggtcaatatg ctccagtccc gtaatttccg tgacgccatc agccatcagt 3574501 ccggctacca ccaagcaggc tccggcacgc agatcactcg ccttcacttt tgcgccttga 3574561 agctcgacag gacctgtgat gatggcagat ctgccttcta ctttcatatt ggcacccatt 3574621 cgtctcagct catcaatgtg cttgaatctt gccgagtaga tggtgtctgt gacgacactc 3574681 gtccctttcg cccttgtcag gagcgccgtc atcggctgct gtaaatcagt cggaaacccc 3574741 gggtatacga gggttttgac gtcaaccggc tttaagttct tctgcccgcc gacaatgagg 3574801 agctggtcgt cgcttgtttc gatatgatag cccatttctc tcagctttgc cgttaacgac 3574861 tcaagatgag tagggatgac gttatcgata atgacttcct tgcccattgc agcccctgca 3574921 atcataaatg tcccggcttc aattctgtcc ggaatgatcg tatgcttgca gccgtgcagt 3574981 tccttcacgc cgtcgattcg aatcacattg gtgcccgcac ctttgatttt ggcgcccatg 3575041 ctggtaagca atgtcgcgac gtcaatgatc tcaggctcct tggcagcgtt ttcgatgatc 3575101 gttttccctt ctgccaaaac agcggcgagc ataatgttaa tcgttgcccc aacgcttacg 3575161 acatctaaat aaatccgtgc gcctctcagc ctttcagctc gcaaataaat ggcgccttgt 3575221 tcattggtta cttcagctcc gagtgcttca aagcctttga tatgctgatc aatcggacgg 3575281 ggccctaagt gacagccgcc aggcaatcca atgaccgcct gcttgaagcg gccgagcatc 3575341 gcccccatta aataatatga cgcgcgaagc ttttttactt tcccgttagg aagcggcatg 3575401 ctgatcatcg acgtagggtc aacaaccatt tccccattct caaaatgcac gttgccgccg 3575461 atttccttta acaggtcacg cagcgtttca atatctgaaa tctctggaag cccttcaatt 3575521 gtcacctcgg aatttgccaa aatggttgca ggtattaacg caacagcgct gtttttagcg 3575581 ccgctgatat gtactgtacc gtttaacgag tcaccgccgg caatattcaa cttttccatg 3575641 atagtctcct tccataagaa gatagctgcg gagctaaata aaatgtcatt ttattctgtc 3575701 tctgcaaata aagctcatgt ccaaaatcta gccaattcga agagaaagaa tacaacacat 3575761 tgtaaaatat caggaagaaa atagcgaagc tttggggggt acaggtttca aaagatgcac 3575821 agagacccgc cggctcgaga gacatcgtcg tcatccggca aaagcagtac gcataccctt 3575881 cattccgata tcagcttctg cagcccaatg attccttctc tgtaaagcgg cgtcagcatc 3575941 tgaagatccg ctgtatcagg tcggtgaaat acaaaggccg cggcaaacag gcataaagct 3576001 gtttgccgcc cctttcatta tttgttccag tctgccagga attgttcgat tcctttgtct 3576061 gttaacgggt gtttagtgag cgcatgaatg actttcagcg gcattgtgcc gatatgagcc 3576121 cctctaagag cagcttctgt cacgtgctgc ggatggcgga ttgacgctgc aatgatttgc 3576181 gtgtcaaggc cgtgaatgtc aaaaatctgt ttaacttctg aaatcaggtc aagcccgttg 3576241 tggccgatgt catctaaacg tcccaggaat ggagatacat atgttgcccc cgctctggca 3576301 gcaagaagcg cctggttggc attgaagatc aatgtaacgt ttgttttgat gcctaagtca 3576361 gtaagtgctc ttaccgcttt taaaccgtca gacgtcattg ggattttcac cgtaatgttc 3576421 ggagcgatct tcgccagttc ttttccttcc tcgatcattt cctcagcttt caaagaaata 3576481 acctctgcgc ttacagaccc tttcacgacg tctgtgatct cgcgaagacg gtcgtggaat 3576541 gatacgttag cttcctttgc tactaaacta ggattcgtcg ttacaccggc gagaattcct 3576601 aattcattcg cttctctaat ttcatcgata ttggctgtat caacaaagaa taacattttc 3576661 aaaaagcctc cctgattaag aaattttctg aactgcgaat atgattgcgc tttctaaaga 3576721 tagacggaaa accgcctgtc aagctgtcag gcggctataa aaagttccaa ttgaattaag 3576781 cttggtttga agaaccaaat tcacgcattt taccgataac tgtttctttg atcgcttcac 3576841 gagctggtcc aaggtattta cgtggatcgt actcgtcagg cttagctgcc aatgtttcgc 3576901 gaacagcttt tgcagaagaa atttggtttt cagtattcac gttgatttta gctgtaccaa 3576961 gtgaaattga ttttttgatg tcagcagtcg gaattccagt accgccgtga agaactagcg 3577021 gaaggccagt tgattttccg atctcttcca tttctttgaa gccaaggttt ggctcacctt 3577081 tgtaagggcc gtgaacagaa cctaatgcag gtgcaaggca gtcgatgcca gtgcgctcaa 3577141 caagctcttg gcactcttta ggatcagcgt agattacgcc ttcagcgata acgtcatctt 3577201 cttgtccgcc tactgttcca agctcagctt ctacagatac tccgtggaaa tgagcaagct 3577261 caacaacttt agcagttgtt gctacgtttt cttcaaatgg atggtgagaa gcgtcgatca 3577321 ttacagatgt gaaacctgca tgaatcgctt tcgcacaaga ttcaaagctt gaaccgtggt 3577381 ctaagtgaat cgcaacagga actgtcactt tgtactcttc cataagtgct tttaccatag 3577441 caacgactgt tttgaagccg cccatgtagc gtcccgcacc ttcggaaaca ccaaggatca 3577501 ctggagattt ttcttcttca gctgcttgta aaatcgcttg agtaaactca aggttgttta 3577561 agttaaattg tcctacagcg tacccttttt ctttagctgt attcaacatt tccgtcatag 3577621 aaactaaagg catgtcgaat gtcctcctta tgtagcctga ttgtcttcta gcgaaaaaag 3577681 ctttccaccc tagcatgacc catatattgc tgtcatatgt aaatactcag atcgcttttt 3577741 ctccataact aggataccaa cttttcgaca aatcggcaac ataatgacat gattcatttg 3577801 tttcttcttt ttgtcagtta gacttcaggg gcagatattt tttgacggcg tctctgattt 3577861 cgtcgatgtc aaacggcttg gcaaagtgcg tcagagcgcc caattccttc gattcctgga 3577921 tcatgtcgag ctctccgtat gccgtcatga taatgacccg gatgttttcg tcaatgacct 3577981 tcatccgttt taagatttcg attccgtcca tgccgggaat tttcatgtcc aacagcacaa 3578041 ggtcgggccg ttcttttgtc acaatgtcaa gcgcctgcag gccgttcgca gcctgaaacg 3578101 tctggtagcc ttctttattg aacacttcat ttagcaaaat acgaatgccg tattgatcat 3578161 caacgattaa aattttttca ttcatcattt tacaccccaa tattatgatt ttcgtcaaaa 3578221 gtaagcagta ttgtatgtat tctgtttgat tttcctattt cctttaatta taatagtcta 3578281 ctttacgaca ttttctgagc attttctctt ttgttgtata ctgatattgt acgttataaa 3578341 ggaggattca cttatgttga aaatattcac gacgcagtta acaggtattt tttcccgcat 3578401 tcaggataag gaatctgacg cgattgaaga tggggcgcgg ctgcttgctc aagcggtgat 3578461 cagcgggcat tccatttatt tatacggagc gaatgagctt cagggcgtct tttatgaggc 3578521 caccgaaagc aaagaaccct tcccatctgt caaagccttt ccagaaaacg ctgaggaagt 3578581 gacagaaagc gacagggtgc tgatgttttg ctcagggacg ggcacagccg aagaacagga 3578641 gctcgcaaaa gagctttatg aaaaaggtgc gggagtcgta tgcgtatcgc ccgcagccaa 3578701 agacagtgcg ggaatagaac agtattgtga tgtgcatatt gattctaaat taaaaatgcc 3578761 gcttgttccc gatgaagacg gcacccgtta cgggtttccc tctttaatga cagcactgta 3578821 tgtctatcac gctttatcgt ttacactaaa agaaattctg caagagtatg cataatatct 3578881 tattgtacat gctggaactt gccggaaaca aataaaaaag acttgcccgc ttttgacaaa 3578941 cggcaagtct tttttattac ttctgatttg cagcttcgac agacgctccg ataaagcctt 3579001 tgaatagagg ctgaggtctt gtcggtcttg acttgaactc tgggtggaac tgagaagcca 3579061 cgaaccaagg gtggtctttc agctcgatga tttcaacaag gcgtccatca gggcttgtgc 3579121 ctgagaatac gaagccttgc tcttccattt gctgtctgaa ttcattgtta aactcatagc 3579181 ggtggcggtg gcgctcgtac accacttcat cctgatacac ttcaaaggct ttcgtgcctt 3579241 cttcaagctt acaagggtaa aggccgagac gaagcgttcc cccaagatcc tcaacatcct 3579301 tttgttcagg aagaagatca atgatcgggt attgagttga cggatcaatt tccgctgagt 3579361 gagcgccttt taagcccaat acgtttcgtg cgtattcaat agacgccacc tgcatgccca 3579421 agcaaatgcc caagaacgga atgttgtttt cgcgcgcgta ttttgtcgcg acgattttcc 3579481 cttcaacacc gcggtctccg aatccgcccg gcacaatgat gccgtctgtt ccgcttgtga 3579541 gttctgcgat attgttttct gtcacttctt ccgcgttgat ccacttcact tttacatctg 3579601 tgtcaaacgc atagcccgca tggcggagag actcgacaac agaaatgtat gcgtcaggaa 3579661 gctcaacgta tttgccgaca aggccgattg taatcgtttg agacaggttg ctgactttgt 3579721 taacaagctc tttccactcg gacatttccg cttctttgca tgccaatttc atgtgctcgc 3579781 aaacaagctt atcaagccct tgtttttgaa gctccagcgg aatggagtaa aggttgtccg 3579841 catcttcaca ttcaataacc gcttttgtat cgatgtcgca gaaaagcgcg attttatctt 3579901 tcatatcttg agaaatcggc atttctgtac gaacgacgat gatgtttggc tgaatgccca 3579961 agctgcgcaa ttcttttacg ctgtgctgtg tcggttttgt ttttaattcg ccagcagctt 3580021 taatgtaagg cacgagcgta cagtggatgt acattacgtt ttcacggccg atgtcgctct 3580081 tcatttggcg gatcgcttca aggaatggca gtgattcgat gtctccgaca gtaccgccga 3580141 tttctgtaat gacaacatct gcgtttgtct ctttccctgc gcggtaaaca cggtctttca 3580201 attcgtttgt gatgtgcgga atgacctgta cggttcctcc aaggtaatct ccgcggcgtt 3580261 cttttttaag aactgttgaa tagattttac ctgttgtcac gttgctgaat ttattcaggt 3580321 taatgtcgat aaaacgctca tagtgaccaa ggtccaagtc tgtttcagcg ccgtcatccg 3580381 ttacgaatac ttcaccgtgc tggtacgggc tcattgttcc cgggtcaacg ttgatgtatg 3580441 gatcgaattt ttgaatcgtc acgttcagtc cgcggttttt cagcaaacgc cctaatgaag 3580501 ctgctacaat accctttcca agtgaggata caactccccc ggttacaaaa atatatttcg 3580561 tcatttcgtt tgctcctctc ttcgctctta gctacatttt taaaatgtac tattttataa 3580621 aaaatcattt agccttttaa atgatttata agaaaaatga ggggtgaaaa taagaaagct 3580681 ccctttcaat ttcttgaaag ggagcataac gtactatgtt ctctcttcgt ttttgaagag 3580741 cccaaaatac atactacata gttcgactat gaaagtcaag atcgttttga agatgaaatc 3580801 tgatactatt taatttcctc ttcttcatca tcatagtctt catcatcttc atcaataata 3580861 tcttcttcga tctcaagatc atcgtcgtct tcatcaagat cttcttcgtc aaaatcgtcg 3580921 gcttcaagat cgagttcttc ctcaacttca tccaaatcaa ggtcgtcttc gtcgatctct 3580981 tcaaactcgt caagatcaag atcttcttcg actgctttct tcgctttttt ctttttcgcc 3581041 ttgactgtcg gctgagtttc ttcatcaagc tgatcataag gataccagct gcgaagcccc 3581101 cacgtctggt cagaaagcgc caggaagcgg ccgtcaatgt ttaaatctgt ataaaattga 3581161 gcaatgcggt ctccaagctc ttcttttttc acgccgagca aagatgcgat ttcatttaaa 3581221 agctcctgaa aaggaactgg ttttttatgt tcttcaaata attcgtgagc gatttcaact 3581281 aaagccattt cctttagctc ttcctgtgaa tattgtttga tacccaaggt cggacactcc 3581341 ctttctatta cttatatgta tctgttttat caataatgaa agcgattttg tatcgttctt 3581401 atacaaacca tacctctcat tataaacaaa ataaaacaga atatgctacc cttaacagcg 3581461 ttaatttaaa taattttaca agagtgatcc gactgagaga tgttttccgt taatccgcga 3581521 gcattctgga gatgaccagt ctttgaattt cttgagtgcc ttcatagatt tgcgtgattt 3581581 ttgcatcacg catatagcgt tctaccggat aatcttttgt atagccgtag ccgccgaaaa 3581641 tctgcacggc ttcggtcgtt accttcatcg ccgtatcccc agccatcagt ttggacatgg 3581701 cggaagcttt tccatatgga aggcccgatg attctaacca tgcagcctga taggtcagta 3581761 gccttgaagc ttctatcatt gtcgccatat ccgcgagttt aaaagcgatg ccctgctgct 3581821 cggcgatcga ttttccgaat tgctttcgct cttttgcata ttgaagcgcc gcatcaagcg 3581881 ctccttgggc gatgcctaca gcttgtgcag ctatgccgtt tctgcctccg tcaagcgtct 3581941 tcatcgcgat tttgaagcct tctccttctt ctccgagacg ctttgatgcg ggcactacac 3582001 aatcttcgaa catgatttcc gttgtcggtg aagaacggat gcccagcttc ttttctttct 3582061 tgcctgtaaa aaatccttca aaatcctttt ctactataaa agcggtaacg ccttttttct 3582121 ttttctcggg atcggtgacg gcaaaaacaa tgtaaatatc agcaacgccg ccgtttgtga 3582181 taaacacttt ggaaccattt aacacatagt catcgccgat tcgttcagca gttgttttca 3582241 tgctgccggc gtcagagcca gaccctgctt cggtcaaagc gaatgcgccg attttctctc 3582301 cgagagccag ctgtgttaag tactctgtct tctgttcctc tgtcccaaag gcaaacagcg 3582361 gccagctgca aagagagata tgggcggaaa gcgtcacacc ggtggaggcg cacacttttg 3582421 acagctcttc caccgcgatg acgtaggcta aatagtcact tccaattccg ccgtaatctt 3582481 caggccatgg aattcccgtc aggcccagat ttgccatttc ccgaaacagc tcgcgatcga 3582541 agcgttcttg ttcgtcccgt tcagccgctg tcggggccac ctcatgcttc gcaaaatcgc 3582601 gcaccaattt tcgtatcatc tcatgttctt ctgataatga aaaattcatt gcttctcccc 3582661 cattttcaga tcagcgccta aaacggattg agccagaagc tcgacgacgt cgtacgtttt 3582721 gacttggtct tcggcttcct tcgcctttgt gccgtcccca agcatcgtga gacaatacgg 3582781 acagccagaa ctgatcaccg atgggttgac tgcgagcgct tgctctgtcc tggcgacgtt 3582841 aatcctgttg cctgtttctt cctccatcca cattaatccc ccgccggctc cgcagcacat 3582901 gccggtttcc cggcttctct ccatttcaac aagctgcacg cccggaatgg ctttcaaaat 3582961 ctctctcggc ggatcataga cttcattgta ccggcccaaa tagcacgaat catggaaggt 3583021 aatcgtctca tgaagcgggt gctgcggtct taattttccg tttttcacaa gctcggccag 3583081 cacttctgta tgatgataaa cctcgccttc aaatccgaaa tccggatatt cgtttttaaa 3583141 taaattgtat gcatggggat cgatcgtaac gatttttttg acatcatttt tttcaaattc 3583201 agaaatattc ttctcagcca gctcttggaa caaaaattca tttccgaggc ggcgcggcgt 3583261 gtctcctgaa tttttttctt tattgccgag aatcgcgaag gacacgcccg cgtgattgag 3583321 cagcttggca aaggaaattg cgattttctg gcttctgttg tcgtaagacc ccatggagcc 3583381 tacccagaaa aggtactcaa attcttttcc ttcttttttc atttctttta cagtcggaat 3583441 ctcagcatcc ggcgcctcgt cacgccaatt ttcacgttcc ttgcggttga gtccccacgg 3583501 attcccttgc cgctcaatac ttgtcattgc gcgctgggcg tcactgtcca tttttccttc 3583561 tgtcagtacg aggtagcggc ggaggtcgat gattttatcc acgtgctcat tcatgaccgg 3583621 gcattgatcc tcacagttcc ggcaagtggt gcatgcccaa atttcttcct ctgtgatgac 3583681 gtcgccgatc aagcttggat tgtaatcaag cgccgctgcg gcttcctgcg atccgctgcc 3583741 cgctgacgcc gcagccagct gattgcctct cgtatgccga aacgctgctg cgggcaccca 3583801 tggggagcgc gaggtgacgg cagcgccttt ttccgtgaga tggtctctga gacgcaaaat 3583861 caagtccatc ggagaaagca tttttccggt gcctgttgca ggacacatat tggtacagcg 3583921 gccgcactcg acacacgcgt atagatcaag cagctgagac tgtctgaaat cctcaatttt 3583981 tcccgctccg tagctttctt tcgtttcgtc ggtaaaatca attttttcaa gttttccggc 3584041 agattccatt cgattgaaaa agacgtttgc cgggccggcg attaaatggg catgctttga 3584101 ctgaggcacg tacactaaaa agctaagcaa gaataggaga tggatccacc atgcgatata 3584161 gaaaatcacc gccgcgcctg ttttcccgac accgctaagc ataaacgcaa tacctgaggc 3584221 aattggctcg ctccaagaaa gcccatgctc atgccaaatc agattcatcc cgttcccaag 3584281 cagaacggtc agcattaatc ctccgataaa aatgagaacg agtccggctt tgaaaccgcg 3584341 tttcagcctc acgagctttt cgatataacg tctgtagaat gcccacccaa cagcaattaa 3584401 aatgagaaac gtaacaattt cctgaaaaaa ggtgaaggcg ggatagaccg ggccaagcga 3584461 cagattccgg ccgggagcca gtcctttgat gataaagtca attgctccga actgaaccaa 3584521 tataaatccg tagaaaaaca tgacgtgaat gattccgctt ttcttgtcct tgagcagttt 3584581 tttctgtccg aatacattca cccatatggc gtgaagccgt tccttgaacc gttgatcaaa 3584641 ttgttctttc tggccgagct tgatgtaggc cagtctcgtt ttgaccaagt aaacaaacaa 3584701 atagacagcg taagcggtta caatcagaaa taataatgca tttgcgatga gaaagccgct 3584761 cattccaatt cccccttttt actgataaag accgcgatcc cctacccccg aatctgtata 3584821 agattatctt tatgataaat aatgaatgag tgttcagtca ataattaaat tcctgctgtt 3584881 cgggcacact acctttacta cggaaaggag tgccggtatg aaggtattta tcgtgattat 3584941 gatcattgtc gttattttct ttgccttgat tctgcttgat atcttcatgg gccgtgccgg 3585001 atacagaaaa aaggcgtacg agcctgtttt ttcaaaaaag aagagtgaca tcgaattgat 3585061 ccactgcggc gctgatctcg ttgagcggat gatgaatgat attcgccagg ccgcctcttc 3585121 tgttcacatg atgtttttta ttatgaaaaa tgatgaggtc agccacaata tgtatacctt 3585181 gctgaaaaca aaagcccaag ctggcgtatc cgtttatttg cttctggatt gggcgggctg 3585241 ccgggcaatt aaaaaaacgg cgcttcagac gatgaaaaat gccggcgtcc atgtccatgt 3585301 gatgaatcgt ccccgttttc cttttttctt ttttcacatg caaaaacgga atcaccggaa 3585361 gattacggtg atagacggaa aaatcggtta tatcggcggg tttaatatcg ccgaagaata 3585421 tcttggaaag aaggcgaagt tcggcaattg ggaggattat catctgcgca tgatcggaga 3585481 aggcgtacat gatcttcaaa cgctttttgc ttctgatcta aaacgaaata ccggaatcga 3585541 actgggttcg gatgtttggc caaagcttca gcaagggact atttctcaca agatctatgc 3585601 gaccgacggt tattcccttg aaaacatata cttggccaac attgcccaag cgaagaatcg 3585661 ccttacggtt tgcacgcctt attacattcc atcaaaaccg cttcaagagg cccttattaa 3585721 cgcaagaaaa aacggcgtat ccgtgagaat cattgtaccg atgaaatcag accatccgct 3585781 ggtacgagaa gcggctttta cgtattattc ggagctcttg gatgccggct gtcttattta 3585841 tcgttattat caagggtttt atcatgtaaa agccctcatc atagacgacc atctcagcat 3585901 tatcggaaca gccaacttcg ataaacggag cctgttctta aatgaagagg tgaatgttga 3585961 aattgatgac gaagcgttta caagtgaagt ctatgccaca attgaggagg atatgaaaaa 3586021 gtcggagctg ctgacgatgg aggatttcag caagcgcaca ttcaggcagc gcccggcgga 3586081 atggctcggc agggcattat cttatttctt ataaaggaga gttcctatga ttttcagatt 3586141 cgggttcgtt tcaaatgcga tgagcctttg ggatgcgtct cccgctaaaa cattgacatt 3586201 cgcgcgttat tcaaagcttt caaagactga aagaaaagaa gcgcttctga ctgtgacaaa 3586261 agccaatttg cgcaatacga tgagaaccct tcactatatc atcggccacg gcattccttt 3586321 gtaccgtttt tccagttcga ttgtgccgct ggctacgcat cccgacgtga tgtgggattt 3586381 tgtaacaccg tttcaaaaag agtttcggga gattggagag cttgttaaaa cccatcaact 3586441 gcgaacaagc tttcatccaa atcaattcac tctgtttacg agcccgaagg aatccgtcac 3586501 aaaaaatgcg gtaacagata tggcgtatca ctaccgcatg cttgaggcca tgggcattgc 3586561 tgatcgctcc gttatcaaca ttcatattgg cggcgcttac ggaaataaag acaccgccac 3586621 tgcacaattt catcaaaata taaaacagct gccgcaggag atcaaagagc ggatgacact 3586681 tgaaaatgat gataaaacat atacaacgga agaaacgctt caggtctgtg agcaggagga 3586741 tgttccgttt gtctttgact ttcatcattt ttacgccaat ccagacgatc acgccgacct 3586801 gaatgtagca ctgccccgca tgatcaaaac gtgggagcgg atcggccttc agccaaaggt 3586861 tcacttgtct tccccaaaat cggagcaagc gatacgcagc cacgccgatt atgttgacgc 3586921 caactttttg ctgccactgt tggaacgctt taggcaatgg ggaactaata ttgatttcat 3586981 gattgaagca aagcagaaag acaaggcgct tctccgcttg atggatgaat taagctccat 3587041 ccgcggtgtc aaacgcatcg ggggcggtgc gctgcaatgg aagtcataaa tgtgcaaaaa 3587101 taggtttacg acttgtcagc tttgggaact taggctatat aagacaacaa tcgatggagg 3587161 agaaagatca tgaaaaatat caagtctctg aaagtagccg cacaggcctt tactttaaga 3587221 aatttgattc atctttataa aatgtgccat tccggaagcc acgaggttta tatttattca 3587281 aagaaaacga tgtgcaaaat caaaagctta attgagcttg aaacgttccg catggctcat 3587341 aatgaaaagg aatatctgat cgtagttgaa ggaacaaaag catcacagct cattgaaaaa 3587401 ttccaaaatc tcatcgagcc tgctgagaga gaagcgctct aacttacata caaaaaagga 3587461 tagacatctg tctatccttt ttcttatgct cttacataat ggagctgaac cgcttgtcca 3587521 aattgttttg tcccttttaa ccgcagtttt gtttcatttg ttagttcgtg aaacagcggg 3587581 atgccgcttc ctaaaacgac gggaataaca gtgatgatga attcgtcgat ggcatcttct 3587641 ttcataaagt cattcacaag ctctgccccg ccagctatcc agatgtttga gcctttttcc 3587701 tgtttcaaac gggcagtgaa ggctctggct ccctcattga taaacgtcac atgttcatct 3587761 tgataactgt cgggcgatcc tgtaaaaaca tagcaggttt tatcctgata cgggaaaacc 3587821 ggtgttagca ctttaacgtg ctcatatgtg ctccgcccta aaatgactgt atcaacagtc 3587881 tgataaaaat cactgtagcc gttgtcacct tcaccttcaa attcatccag ccaatcgatg 3587941 cttccatctt cttttgcgat catcccgtcc aatgaaacag caatgtacag cacagttttt 3588001 ctttccatgt tctcctccta tcgatgcacc atttgcccga attgcgcttg atgcagcctg 3588061 ctgtataggc ctccggcttc gatcaggtct tgatgacggc cttgttcttc aataccgttg 3588121 tttgtgacga ctacaattct gtccgcgtct ttgattgttg ccagcctgtg ggcgatgaca 3588181 agcgtcgtgc gcccctcaga caactcttga agcgcctttt ggatcgccgc ttccgtctct 3588241 gtatcaaggg ctgaggtggc ttcgtcgaga atcaagatcg acggattttt caagaacatc 3588301 cttgcaattg acagacgctg tttttgcccg ccggaaagct tcacgccgcg ttcgccaatc 3588361 atagtatcca acccatcggg catgttatgg acgagctctt ccagatgcgc ctgcttcaca 3588421 gcttgccaaa tgtcttcttc tgatgcgcct agtcggccgt aggcgatatt ttctctaagc 3588481 gtgcccgaga ataagaaaac gtcctgctgc acgacgccaa tctgcccgcg caacgaagaa 3588541 agcgtcatgt cttttatact gatgccgtca atcgtaatgt cgccctccga tgcttcataa 3588601 aaacgcggaa gcagactgca aagcgttgat ttcccagcac ctgacggacc gacgaacgcc 3588661 accgtttccc ccgcttgaat ggataggttg atgtcattga ggacattgtg atggtcatca 3588721 tagccaaacg aaacatgttt atagcggata ttgcccttca ggccggaaac atctttcgaa 3588781 tcaggtgagt cctgaatatc cggctctgtc tccatgagct ccatatagct tttgaaaccc 3588841 gcgatccccc tcggatacat ttcgataatg gcattaattt tgtcaatagg cctgaacagc 3588901 acattcgtca agagtacaaa cgccacaaat tccccgtacg ataaggagcc gcgaatgaca 3588961 aaccacgtcc cgcacaaaag gacaaacagc gtgacaaacc gggtcagcat atagctgatt 3589021 gaaccgtttt tcgccatgat tttgtaggaa gaaagctttg tgacacgaaa acgctggttg 3589081 ttgacggcga agcgttcttt ttcaaatgct tcatttccga acgcctgcac aagccggatg 3589141 ccgccgatgt tattttctac acgcgcgctg aagtctccga tatccttgtt cagcgtggta 3589201 aatgctttgg tcattttttt gttgaaataa agcgctagcc aaatgacgat cggcataatg 3589261 ataaacgtta ataaagcaag ctgccagtta ataaacagca tcactccgaa cgccccgaga 3589321 atggtcatga ccgcaatgaa taagtcttcc ggtccgtgat gggcgacttc accgatatac 3589381 attaaatcgt tcgtgagctt cgacatcagc gttcccgtct tgttgttgtc gtaaaatttg 3589441 aacgagagct tttgcaaatg gtcaaaaagc gactttctca tatcagtctc aatattgata 3589501 ccaagcatgt gtccccagta ggtcacgata tactgaagag ccgagctgag cgcgtacacc 3589561 gcaaataacc cgattgaggt cgcgatgatc agtccccagt ccctgcccgg cagcaaggta 3589621 tcaataaaat aattgacgat caaaggaaaa ctcagctcca ttaaacctcc cgcgatcgct 3589681 gagaaaaagt cgagaaagaa caacgtttta tatggtttat aatatgaaaa aaattgccgc 3589741 agcaccctat cttcccccaa tgtataaata actgataata tttctcaatt atactataca 3589801 cgggctgttt tgtaagatca gatttctttt ttcttacaga acacctgaaa acaggcgggc 3589861 aaacgactct tttgtccggt cagccacacc tcttttataa aagccgacag ggctgagctt 3589921 ttcactttcc tgcatatcct cttcaaaatg ggcctcaagg gttcggatcg cttcggcatc 3589981 cgtgaagaac acattcactt caaagttgag ctgaaagctg cgcatgtcca tattcgcggt 3590041 accgacggag gcgagatcgc catcaatgat catgactttt tgatgcatga agcctttttg 3590101 gtaggagtac acttcaatgc cctcaaggag cagctccggg aaataggacc tcgacgcgta 3590161 ttgggtcaaa aagctgtcgt tcttctccgg caccataacc cttacctcta ccccctttgt 3590221 cgccgctgct tttagcgccg tgcgaatgga ttcattgggg acaaaatagg gcgtggcgat 3590281 ccatattgat ttctgcgctg aagaaatcat ttcataataa aggtcgctca tgctttcctt 3590341 catgtcaggg cctgtcgcga caatttgata aatgcctcct ccttccacgg gaaccggggt 3590401 attgtactcc tcttgatcaa ttagcacttc attggagaca tattcccaat ccagcataaa 3590461 gatagcgtgg agcgtttgca caatttcccc ctcaagccgc aggtgtgtat ctctccaaaa 3590521 tccgatgtac ggatctctgc tgatatattc cttcccgaca tttaatccac ccacaaaacc 3590581 ggttttccca tcgatgatca cgattttccg gtgatttctg aaattcagct tctggttgaa 3590641 aaacccgtat ttcagcggag aaaacgggac gatgtccacc cccgcttgtt tcattctcat 3590701 aatatctctt cttgccagct tcatgcttcc tgccgcatcg tataaaaacc tcacctcgac 3590761 accctggcgc gctttctcca tcataatatc catcatgccg cgtccgagca tgtctgattt 3590821 aaacatgtag tattcaatat gtatgtaaga ttccgctttt ctcattgctt tgaaaatgtc 3590881 cgggaaggtt tcttcgccgt ttttcagcac tttgatgttg cttttcgtat tgatattcat 3590941 atgggcagcc ctgatggaat atgtaaagaa cctctcttga ttgtccttca gccctgtcac 3591001 ttcgggcgtt tcctccttgt caaacagctt cctgagcttt tccctgttgt acattcgttt 3591061 tgtcttaaac agctttccct ttacataaag ctgtcccgaa aacagataaa acacgtagcc 3591121 gacgattgga aaaaagacaa gaatatggat ccatagcagc gtgtgctgcg aggtgcggtt 3591181 ttcaagaatt aatgaataga tgctgaacaa aataatgctt atatagcaaa gcaatcctcc 3591241 gtaaaactca agtctggaaa ccggaaaaaa ccaaatgaca tatgccccga tgagcatcat 3591301 atataaaaag aaaaattcca gtctcctttt cagcatcctg attctctcca atctgattca 3591361 attacctctg tattacctct tttttctaat cgataaacct tgtaagtaaa aaacctctcc 3591421 gccaaaggag gagaggttta gagaaaacta actgtcacgg aattcatccg catcgtttct 3591481 gcagaaataa agcaagacta ttggcaacgc cgagtgacaa catgagcggc aagctgaacc 3591541 cgctcagcac tccggcaagc gccgaaaaga aggcggcgct gtgactgcaa atacggtgga 3591601 tagagtaaat ttgataccca ttctgatgag agaaaatata taaaacggga aattgatcag 3591661 aaagatataa ggagttagtc aggctgaatc ataatctggc tgttccgccg gtttaaaatg 3591721 agtaaaatcc ttgatgttat ttccatatac aaacataaca ggattcccgg cagcccagcc 3591781 attaccttgg cagaaaaaac cccctcttgc aagggggatt ttcacgagcg tttccgatat 3591841 acaacgtagc tgcgggtcag atacttgagc ggcagactga acacatgaac caatctcgta 3591901 aacggccaca ggataaaaac gacgtatcct atcacaatat gaaacttaaa ccatagcggg 3591961 acactctcca tcaaagaggc gtcaggcctg aacaaaacga tttccctgaa ccagggcccg 3592021 actgtggtcc ggtaatcaaa tcctttcgaa tcaatgttga gaaacgtggc cgcaacgcct 3592081 gacagcatca tgaacagcag caggaggagc gtaaggatat cggatggcga gctcgttttg 3592141 cggattcttt tgtcaaacag ccttctgtac gtcaggatga caagtccggt acatgccgca 3592201 atgcccgccg gcaagccagc gccaatcgcc attttgtgat acatatgctc tgaaatgcca 3592261 agggaagcat acacgccttc tgggatcaga atccccatga catgcccgcc gacaacgcac 3592321 agcagtcccc agtgaaaaag tgtgctgcca gccgcaagtt ttttcttttc taacagctcg 3592381 cttgatttcg ccgtccagcc aaattggtca tgctgatagc ggtaaatatg gccgccgata 3592441 aagattgtca atacaatgta tggcataata ccccagagga tctgcccgct catgcctgaa 3592501 cagccccttc aacgctttca cgtacgccaa tgttttcaag cgcggccagc agcacgtgca 3592561 gcagttcagc gtatatactg tcattttttt cgagacggga tgccagctcc ctcacattgg 3592621 acagatattt ctcaaacacg cttctcgctg cttcaatttc tgcagccgca gcaaattcca 3592681 gcatcagcgg cagataatca ggcagctctt tctctgtcgg caggaaaccg gattgctcgt 3592741 atgtgttttt taaatgcagc aattcaatgc cgcgttccct ttgctcgcct gagttaaagt 3592801 aggtgacata catatttgtt tttttcccga agtcgaatgt atagacatag tgttcaatca 3592861 gcgcttccgg agaatagctg gctgacgtct cgaaaaagtg cagcagcttc tcccggattt 3592921 gccggttgcc gatttcttgg ataagagcct tccaatcggg aagctcggct ctccactctt 3592981 catccggata agagagaaga caggaaagag cagagaacgt gatttgccgg tctgtggtgt 3593041 tcatcttgtt acacctcatt tatcaaaagt tagaaacagg agccggggcc gcctgaaaat 3593101 gataagccgc agcttccttg ttcagcgtat aaatctgata cttcttctcg atggctgctc 3593161 ggaatcacaa agcggtcatc atatttggca atcgcaagca gccgatacat atcttcaatt 3593221 tgctgttctg ttaagccgac actggagatc agttccggat cgattgattt attcgtctgg 3593281 accgctctca tatactggcg catgacagac attttcttta atgttgaccg aatatgatcc 3593341 gtatcaccgg ctgttaacag ctgcgccaaa taatctatcg ggattctcat ttggtcgata 3593401 gccggaaaaa tatcttccgc cgtttgccgg ctgccttttc cttcaaagag attcataatc 3593461 gggctgagcg gcggaatgta ccacaccatt ggcagcgtgc ggtactcagg atgaagcggc 3593521 agcgcgatct tccagtcaat gatcatttta tagatcggtg attgctgcgc ggcctctatc 3593581 cattcagccg gaatgccttg ttcttttgcc agtttggcaa cctcaggatc attcggatca 3593641 agaaaaacgt ccaattggga atggtagaga tccttttcat tttcaacaga tgccgcttcc 3593701 tccactttgt ccgcgtcata tagcatgacg ccgaggtagc ggattctgcc aacacacgtc 3593761 tcagagcaga tggttggcag tcccgcctcc aaacgcggaa agcagagtgt gcatttttcc 3593821 gctttgttcg tttgccagtt aaaatagact tttttataag gacaggatga gacgcaatat 3593881 ctccatgaac ggcatgcgtt ttgatccaca agcacaatgc cgtcctcctc gcgtttgtac 3593941 atggcgccgg atggacagga tgagacgcat gccgggttga tgcagtgctc gcaaatacgg 3594001 ggcaaataca tcataaagac gtcatcgaat tctgttttga tcgattcctc catcttttgt 3594061 acgttgggat cttcaagtcc cgtaatgtgg ccgcctgcga gatcgtcctc ccagttcggt 3594121 ccccattcga tattcatgaa atcccccgtc aaggacgatt tcgggcgtgc taccggctgg 3594181 tgttttttct gcgggctgtt cgttaatgtt tcataatcat agttccaagg ttcatagtaa 3594241 tcatcaattg acggctgatt cggattatag aaaaggcctg caagccgatt ggttttcgag 3594301 cccgatttca gctcgagctt tccttttttc aatgtccagc cgcctttata tttgtcctgg 3594361 tcctcccatt gcttcgggta gccgatgccc ggctttgttt ctacattatt gaagtacata 3594421 tattccgcac cggaacggtt tgtccacgtg tttttgcagg tgacgctgca cgtgtggcag 3594481 ccgatgcatt tatccaagtt catgaccata ccgatttgcg ctttaatctt caagccaatc 3594541 gacctccttc agcttgcgga tgacgacgtt caggtcgcgc tgattccccg ttggaccgta 3594601 ataattaaag ccgtagctga gctgggcgta gccaccgatc atctgtgtcg gcttgacgtg 3594661 aatccttgtc gggctgttat gggtgcctcc gcggttattc gtcagctttg tgccgggcac 3594721 gttgatgtgg cggtcctggg catggtgcat aaacgccatt cctttaggaa tccgatgaga 3594781 caaaacggct ctcgcgacga caacgccgtt tcggttgaag cattcaatcc aatcgttgtc 3594841 tttgatatcc gtgtcctctg catcatcttt attcatccac acggtcggcc cgccgcggaa 3594901 cagcgtcagc atcggcagag aatcaaaata catgctgtgg acagaccatt tattatgcgg 3594961 cgtcaaataa ttgaggacga tttcttttcc ctcttgatca ggccgtttgc tcagaaacgg 3595021 gcgatgctgg aggatcggtt tgaatgtcgc catcgtttca ccgaattcca tcatcagttc 3595081 atgatcgaca taataggatt gtctgcctgt cagcgtccgc cacggaatta atttttcaac 3595141 attcgttgta aacggcgaat acctgcgccc tcctttttca gagccggtaa acgctggaga 3595201 cgtgatcacc gttttcggct gggctgtaat ttgttcgaac gtaaagcatt cttcctcgcg 3595261 ttcttccgcc aggtctttca gcttcaggtt cgtgatgttt tcaagtgatt cccatgcttt 3595321 tactgcgacc tttccattcg aagtggatga tagggttaaa atcgcttctg cagcctgctt 3595381 tgcttcactt atatttggac atccctttgc cacgctgtcc gaggtgattt ctcccagtct 3595441 ctgtttgagt gattcatatt catcggctat tgaccagctc atcccttttg ttccgctcgg 3595501 ctttaaagca acgttcggac caagtgcagt cattttatga aaaatgtgtt tgtaatcccg 3595561 ttcaacgact tggatgttcg gcatcgtttt tcccggaatg gcttcacatt cgcctttgct 3595621 ccagtcattg attttgccga atggctgggc caattcctgc atggtgtcgt ggagcagcgg 3595681 tgtcgcaacc acttctttca ccggctccat atcgacttct tctgccagat cggaaacggc 3595741 ttttgacagc gccttgaaaa tatcccagtc tgacttcgat tcccacggag ccgagatcgc 3595801 aggagcaaat ggatgaatga acggatgcat atctgtgctg ctgagatcgt gtttttcata 3595861 ccatgtcgcc gccggcagca cgatatcgga atacagcgcc gtacccgcca ttcgaaaatc 3595921 aagattgatt aataagtcga gctttccttc cggcgcctgc tcccgccatt tgatttcttc 3595981 tgggcggatg ctgtcgctgt cgtcattcat taaaccgttc gttgtcccca gcaaatgctt 3596041 gagaaaatat tcatgccctt ttcctgagct tgagatcaga tttgcccgcc atacaaagag 3596101 attccttggg aaattcactt cattgtcagg atcttcaatc gcgaatttca gttttttctc 3596161 ttggagctgt gaggccacgt acgcacctac gtcttcaggt gttgctgccc ctgctttttc 3596221 agcttcttta tacagatcga tgccattttg attgaaagtc gggtaagacg gaagccaccc 3596281 tagccgcgcc gccagcacat tgtaatcagc gtggtgcttg tagcgggatg aagcagcaat 3596341 cggtgatgcc aaatcactga tcggctggtc ctcataacgc cactgatctg tcgcaaagta 3596401 gaaaaatgag gtgccatttt gcagcttggg cacgccttcc cagtcctttg cagttgcaat 3596461 cgtctgccac ccttcagcag gtcggagctt ttcctgcccc acgtaatggg cccagcctcc 3596521 gccgtttacg ccttgggcgc ctacaagtaa aacaagattt aacactgctc ggtagatcgt 3596581 gtcggagttg aaccagtggt taatgccggc ccctacgata atcatggacc ggccgtctgt 3596641 atcgatcgca ttttgggcaa actctctggc aatcttaacg acagcttctt ttttgattcc 3596701 tgtcatttgt tcctgccagg caggcgtaaa cggctcaggg tcatcatagg agacagccga 3596761 tcgttcgccg atgccccggt tcacgccgta gttagccagt atcaagtcaa acacggtcgt 3596821 gatgtacgtt tcttcaccgt tcaggttcat ttttttaata ggaagatccc gctcgagcac 3596881 tttgtttccg tcatttgaaa aatacgggat gcgcaccgtg ccgatttcgt cctctattcc 3596941 cagcacagag agacggggtt caatcggttc cccggtttct tcatcaatca tgtgcaggtt 3597001 ccatttctgc tgcccgtccc agcgcgagcc cattgtccct tggggtatgg caaatgaact 3597061 tgtctgttca tcccaaaccg caggcttcca ctgatcatgc tttgtcttcc gcccgatgtc 3597121 cttcgcatgc agaaaccgtc ccgctgtgta tacgccattt tcttttgaca gagtgacgag 3597181 aaatggaaaa tcagtgtatt gcttcgcgta ctcaataaaa cgttcagttt cttggttcac 3597241 gtaaaattcc tgcagaataa cgtgacccat cgccatcgca agcgccccgt cagtcccttg 3597301 gcgaatactc agccagtcat ccgcgaactt tgaggattcc gcaaaatctg gactgatcga 3597361 aatgacctta gcgcctttat agcgggcctc cgccaaaaaa tgcgcgtcag gcgttctcgt 3597421 taacggaacg ttggagcccc atgtgataat atagccggaa ttgtaccaat cactgctttc 3597481 cggaacgtcc gtctggtcac cccaaatttg cggggatgct ggaggaagat ccgcatacca 3597541 gtcataaaaa ctgagcatag ggcctccgat taacgacata aaccgggagc ctgatgcgtg 3597601 gctgatcatg gacatggccg gaatcggaga aaaaccgacg tttcggtcag gcccgtattt 3597661 catcactgta tacagcagag aggctgaaat cagcttcagc acctccggcc attcagcgcg 3597721 cacaaaaccg cctttccctc tcgcctgttt ataggacttc gctttttcag ggttttcgac 3597781 gatcgatttc caggcttcca atggattttg atgcgtctgc aatgcctccc gccacaaatt 3597841 gatcagcaca ccgcgcacgt atggatattt cacacggagc gggctgtaga tataccatga 3597901 aaaactggcc ccccgcgggc agcctctcgg ttcaaaatca ggcatatccg ggcctgttga 3597961 tggataattc aaattttgcc cttcccacgt gactattccg tttttcacat aaatattcca 3598021 gctgcaagac cctgtacagt tgacgccgtg ggtggagcga acgactttgt cgtactgcca 3598081 tctgtttctg tatacattct cccaatcgcg atcctcgcgg gtagtttggc tatgtttatt 3598141 tgaatggtgt tcgataggag agaaataatt caatctccta aacaacggac tccttttctt 3598201 tttcttcatg agagttcact ccttccgagt caggtgatgc taagttcact ataaacagag 3598261 acagcgtgtt tccttgtgaa ctatgtcaca cactctgctt ttttcacaaa atgttcacac 3598321 aaaggagaag gaaggctgcg ttcaggcagg acgcttgggt cattagctgc ctttcattca 3598381 aagatcaaaa aaaaccggct ctatttaaga accgggctca gcgttttcat cctgtgatgt 3598441 atgcagatac cgcaaaaata attgatagga acaaaaaaca ttttgctgaa gcatagccaa 3598501 aaagttcatt tgcagctgcg gatgataaga catcattttc ttaaatatgt aatatgggat 3598561 gttgagaatc agaatgtctg aagtggcatt gactgagata aagggcgata aataaagccc 3598621 gcctttttca tcaatcggaa acacatcgcc tttttcccac agcgcaacgg ttttcgaccc 3598681 ttcagggagc cttgtgtcca taaaacggac actgcctttt aatacaatat aaacagattg 3598741 agaatgaaga aaagatggag actgatcaca tgaaccgcgg ataaacgtgc cgtttttcag 3598801 caaggtttcg acaatggata gaggcacttc attaaacata ggaagttgtt tcagaaataa 3598861 taaatagtca cactgattca taggaaaacc tcctgtgcta aggatagctt tagtgtagct 3598921 cgactgagcc tgtacagcag tgatgtattt cacagcctgt atgatgaatg tcacttatca 3598981 ggagggtgaa tgcatttata atgaaagaaa aaaggaggat ttcgatgaag gcgctgattc 3599041 cgaagcagca cggggcgtgg gcgatgctgc tgatcccatt tttactcggc atggtcaagg 3599101 gaggccccgt tatttggcat attccgctct tccttggttg gcttttccta tacttagcgg 3599161 tttatcccgt tacgcttgcc ttaaaaaaga aacaaagcaa accatatcaa aagtggatgt 3599221 gttattacgg ttttcccacc tgctgctttt tgatgatctc ggtctttcat aagccgcctc 3599281 tcatctgggt gggcgtttct ttactgccgc tgtttctcat acatatgtat tttgcccgca 3599341 gaaaaaacga acgagcctta ttgaatgatg ttgcaggtgt cttgttcttt tgttcgggcg 3599401 ggtttgcgag ctgctggctg gggatgggaa cccttgacgg ctgggcttgg tttattttct 3599461 tgcagtctgc tttatttttt atcgggagtt ccttttatgt gaaatcggtg atccgcgaga 3599521 gaaaaaacag ggcatttgca tactggtcat ggggatatca cctgctgctc ccctttttat 3599581 ccgctctttt cggagcagga tgggcgtttc tcgcttttat cccgagcagc ttgcgggcat 3599641 ggttttttca tggaagggat tggcccgtaa aaacgattgg cattctggaa atcgtgaatg 3599701 cctgcttctt tcttgccgtc atgtgcctgt ttatcacaag gtaaaaaaac aaggacaccg 3599761 ctgtccttgt ttttttcagt caatattgca aatctccagc gggcaatttt cacactcaat 3599821 ctcacatcgt aaatagtccc gcttgtgcaa aataattttt ccggattcgt ctatcgaaat 3599881 aacccctttt ttgcggagat ctccgagcat acgattgacg ctttcccgtg cagccgcgca 3599941 aaactttgcc aaatcctgat ttgtcaggac aatgttaatc agaatgccgt cgcttcgctc 3600001 cactccgtag ctgtttgata agcggataag ggtagaatag agcgccccct ttttgccatg 3600061 aagaagcaga tccctgattt tggactgaat cttccggagg tgcgtgctca tccatttcat 3600121 gaactcaaat gtcaaagcgc cgttttggat taattctttt tccagcttat ttttattaat 3600181 gacgagcacc tcgccatcct ctagtacttt tgcactgagc atataccttg gttcttcagt 3600241 gaaaagtgtt aattctccga cgatatcatg cttttggcag attctaagcg tcaggtcttt 3600301 tccgtcagat gtcagcttgc cgatttcaat gagtcctgat tgaatcagat aaagctcttc 3600361 tgcatccatt ccttcccgaa acaaatacgt gtgtttttcc atttttcttt tcgtgctgat 3600421 cgattccagc aattcataca gatcgctgga tataagatca ctatcagatg gtcgaacaga 3600481 gagaaaattc atgagctcac ctcgaagaaa gtcacgttgt gtgtttattg taacgtgaat 3600541 tgatttgtac ccatcgagaa aaaactaaca atcttgtgaa tgccccagtg ttagttgatg 3600601 ctctggctgt ttctctccgt gtgtgttttc attctttcct gccaatacat ccatatgaca 3600661 aggacaaaac tggctaacgc cacctctgaa agcgccataa acccgatcgc gtactggcct 3600721 gttgcctgaa atacactcgc caatatgagc ggaggaaaaa agccgcctaa accgcccatg 3600781 gcagacacaa tcccattggc aatccccgct tgcttcgaaa aatagaaagg caccagttta 3600841 aaaacagttc cgtttcctat gcctgagcag acggccacgg ttaatgatcc aaacgtataa 3600901 aggccgattg tcggcgagaa cgataggata atgcctgata atgtaagccc ggcaaaaaca 3600961 aacatcaaga tgcggagcgg gctcatttta tcagccagga atccgcccgc aggcctgagc 3601021 agcgtagaaa ccgcaataaa gccagccgtc cgcaagccgg catctgcagg attcagccca 3601081 aaatgctcca ccagaaagtt cggcagatag atagtgaagg cgacaaaggc accgaacgta 3601141 ataaaataaa acaggctcag aaaccatagc acatgatttc ggtaaacagc tttgatttga 3601201 gtcttaacag aaactttgac cttcttctca tgcctgtcgc caaacaatac gtgcagtaag 3601261 gcaaagacag ccagcaaaat cagatacatt tgcacggttg atttccaccc gacggcttga 3601321 gcgataaccg gcgctgcaaa tgtcgtaacg gctgtcccga tatttcctgc accgtaaatc 3601381 ccattgacga caccgtgctt ttctttcgga taatatttcg ggagggaggt caccccaatg 3601441 gaaaacaccg ctcccccgat ccctaagaaa aagccgcctg cgattaaatc aaacagagaa 3601501 tccgcgatac tgatccaaaa tacaggaaat aaaagcagga tgaagctgac cataaacatg 3601561 agccgcgcgc caaacctgtt cgttaaatac cctaaaggaa tgcggagaag cgacccgagg 3601621 atcacaggaa tcgcggtcac taaagaaatc tcacccttgc ttaaatgaat atctaatgtg 3601681 atttgggaaa tgagtgatga aatcagcacc caaaccataa accctgccac caagcttaat 3601741 gactgtaacg ataattgaat gtgttgacgg ttgatcattt ggcttgcccc tttcaatgat 3601801 tcaataatca gtcttatcat acaaaaacta gccaaacagg attgtgaatt acatcacacg 3601861 tttttctcat aaaaaaagga caaagcccga agactttgtc cttttgatcg tgattacatt 3601921 ttttccggag ccgatacgcc gatcagctga agcgcattgt tcagcgtaat ttgcgttgcc 3601981 ttcattaaag ccaggcgcgc gcggcttttc tcttcatttt cagggtcgat gactttctct 3602041 gcgttgtaga agctgtgcag agcagaagcc agatcataaa tatagttagt gacacggtgc 3602101 ggaattcgtt tttccgctgc ttccgccact gcctctggga agccgccgat cgttttcagc 3602161 agatcgtatt ctttttctga ttgaatatgg ctgaaatcaa gatctgccgc cggtttaagc 3602221 ccctgctctt ccccttggcg aagcatgctg caaatacggg catgcgcgta ttgtgcataa 3602281 tacacagggt tttcgttaga tgttgataca gcaagatcta agtcaaaatc catatgggtg 3602341 tctgcacttc gcattgcaaa gaagtaacgc acggcatcca agccgacttc ttcaatcagg 3602401 tcacgcatcg ttacggcttt accggtccgt ttgctcattt tcattttctc gccgtttttg 3602461 taaaggtgaa cgagctgaat gatttctact tcaagcgttc ctttttcata gcccagcgct 3602521 tcgattgccg ctttcatacg cgggatgtag ccgtggtgat cggcgcccca aacgttgatc 3602581 agcttatcaa agccgcggtc aagcttgtcc ttatgatacg cgatatcagg aagaaggtac 3602641 gtgtacgtgc cgtccttctt gatcaatacg cggtctttat catcgccgaa agtcgtggaa 3602701 cggaaccaag tcgcgccgtc ttcttcatag acgtggcctt tttcgcggag cgcttcaagc 3602761 gccttgtcga tttttccatt ttggtacagt gaagtttctg aataccacac atcaaacggc 3602821 acacggaagt tttccaagtc cttgcgaagc ttttccagct cgtatttcag gccgtattca 3602881 cggaaaaacg cgaggcgttc actttcctct tcgttaacga aacgatcacc gtattcctca 3602941 gcgagacgct ttccgatcgc aatgatatcc tcaccgcggt agccatcctc cggcatcggt 3603001 ttttccaatc cgagtgcttc aaagtaacgg acttcaacag aaagcgccag attgttgatt 3603061 tggtttcccg catcgttaat gtagtattcg cggcttacat cgtaacccgc ttttgaaagc 3603121 acgttgcaca aggaatcgcc gacagccgcc ccgcgcgcat gcccgaggtg aaggtctccc 3603181 gtcggattcg ctgatacgaa ttctacctga actcgttcac cgtttccgat gttcgtttcc 3603241 ccgtatgctt cccctgcttc cagtacagac ggaatcagct ttgttaaata ttgattgttc 3603301 atatagaaat tgataaaacc cgggccggcg atatccagtt tttcaatcga agccttccct 3603361 ttatcaaaat gggcgacaat ctcttcagcg atttgacgcg gcgctttttt tgccactctt 3603421 gccaactgca tcgccatatt cgttgagtag tcgccgtgtg ttttatcttt cggtgtttct 3603481 aaaacaacat tgggaatctg gctttcttca gccagtcccg ctttcagaac ggccgctttg 3603541 atttcttctt tcagcacgtc cttcatttgt tccgcaatgt tcatgcgtga gttcctccct 3603601 catacgtgat cgtcatatta tgtaaatgct cctgctcgtc tccgacatgc atgtcatatg 3603661 cgatgctgat acggcctttt tcttcatcga gatcagattg aatcgatttt gtgcttgttt 3603721 tcagctcaag ctcaccaaat gacattttat atttagcaat tgtggaagct cccgttacga 3603781 aacgctgatt cattttgaca gcgcctgacc tcatgaccag gacttcgcct tcgcttactt 3603841 tcacaatcgt tttgactttg cctaagtcgt gttcttcata ataagataga tacactttat 3603901 tttgttttac atagtaaaat ccggtggtgc ggaattcgat gacttcttgg tttccgtcat 3603961 cctcgatcac agacttcaca tggagtgtta tcggtgtctc ttgcttcatt ctgacacgtc 3604021 cttttcatca ttccactttg acttgaatag tataatcatt cggtttgtaa acttcaactg 3604081 cttctatctt accatcattg ctcatcagat ttgaagataa acctcataaa aagcatttcc 3604141 ttatatagaa gagaaaatca tatcactaat tacctttagg aaatgttaca tttttccgaa 3604201 atctatcatt tccttttcac atttttttca aaatatatgt attgaattag taatttgata 3604261 gttttaagat aaaagtacaa catagatctg ctagaaaaac aaaaaaaggg aggattcaat 3604321 tatgaaaaaa gctgtcattg tagaaaacaa aggttgtgca acatgctcga tcggagccgc 3604381 ttgtctagtg gacggtccta tccctgattt tgaaattgcc ggtgcaacag gtctattcgg 3604441 tctatggggg taaggatctc ccaaaagggc atagtcattc tactatgccc tttttaagta 3604501 aattacaatt tttaactaaa atctacctct tggatataca tacacaaccg tttttcattt 3604561 gaatcatatg tataggggat ggtattttgt ttatagagca gatgtttcca tttattaatg 3604621 aaagtgtaag agttcaccag cttcctgagg gcggcgtgtt agaaatcgac tacttgcgcg 3604681 ataatgtctc catttctgac tttgagtatt tggatctcaa caaaacggct tacgagctct 3604741 gcatgcgcat ggatggccaa aaaacagctg agcagatttt agctgagcaa tgtgcagtgt 3604801 atgatgaatc accggaagac cataaagatt ggtattacga catgctcaac atgctccaga 3604861 acaagcaggt tattcagctt ggaaaccggg ccagccgcca tacaatcacc acgagcggaa 3604921 gcaatgaatt tccgatgccc ctgcacgcca cctttgaact gacgcaccgc tgtaatttga 3604981 aatgcgccca ctgttatttg gaaagctcac ctgaagcgct cggcaccgtg tcgattgagc 3605041 aattcaaaaa aacggctgat atgctgtttg ataacggtgt attgacatgc gaaatcacag 3605101 gtggagaaat ttttgtccat ccaaacgcca atgagattct tgactatgtg tgtaaaaagt 3605161 tcaaaaaagt cgctgtctta acaaacggaa cactcatgcg aaaagagagc ctggagcttt 3605221 tgaagactta caagcaaaaa atcatcgtcg gcatttctct agatagtgtc aattccgagg 3605281 tccatgactc ctttagaggg agaaaaggct cttttgccca aacttgtaaa acgataaaat 3605341 tgttgagtga ccacggtata tttgtcagag tcgctatgtc tgtcttcgaa aaaaacatgt 3605401 gggaaatcca cgatatggcc caaaaggttc gggatctcgg ggcgaaggcg ttttcttaca 3605461 attgggttga cgatttcgga agaggcaggg atattgtcca tccaacgaaa gacgccgagc 3605521 agcaccgcaa gtttatggaa tacgagcaac atgtgattga tgagtttaaa gatctgattc 3605581 cgattattcc ctatgagaga aaacgcgcgg caaattgcgg cgctggctgg aagtccattg 3605641 tgatcagtcc gttcggcgaa gtacgtcctt gcgccctctt tccaaaggaa ttttcattgg 3605701 gaaatatttt tcatgattcc tatgaaagca tctttaactc ccctctcgtc cataaactgt 3605761 ggcaagcgca agcgccgcgg ttcagcgaac attgcatgaa agacaaatgc ccgttcagcg 3605821 gctattgcgg aggctgttac ttaaaagggc tgaactctaa caaatatcac cggaaaaaca 3605881 tttgctcttg ggcgaaaaat gaacaattag aagacgtggt ccagcttatt taggagggaa 3605941 acgatttgtc accagcacaa agaagaattt tactgtatat cctttcattt atctttgtca 3606001 tcggcgcagt cgtctatttt gtcaaaagcg attatctgtt tacgctgatt ttcattgcca 3606061 ttgccattct gttcgggatg cgcgcgcgga aggctgactc gcgatgagca ttttggatat 3606121 acacgatgta tccgtttggt atgaacggga caacgtcatc ttagaacaag tggatttaca 3606181 tttagaaaaa ggcgccgttt acgggttact tggggtaaac ggcgccggaa aaacgacact 3606241 gattaatacg ctgacaggcg tgaaccgcaa tttcagcggg cgttttacac tgtgcggaat 3606301 tgaagcggag gccggcatgc cgcagaaaac atcagatcag ctgaagactc accgttactt 3606361 cgccgccgat tatccgctgc tatttacaga aattacggcg aaggactatg tgtctttcgt 3606421 ccattcgctt tatcaaaagg atttttcaga gcagcagttt gccagtttgg ccgaggcctt 3606481 tcatttttcg aaatacatca ataggagaat ttcggagctg tccttgggga acaggcaaaa 3606541 ggttgtattg atgacaggct tattgctgcg cgctcccctg tttattttgg atgagccgct 3606601 cgtcggtttg gatgtggaat cgatagaggt cttttatcag aaaatgcgtg agtactgtga 3606661 agcaggcgga accattttgt tttcttctca tctgctcgat gtcgtgcaaa gattttgtga 3606721 ttatgcggct attcttcaca acaaacagat ccaaaaggtc attccgattg gagaggagac 3606781 cgatctgcgg cgggaatttt tcgaggtgat cggccatgaa taacataatc cctatcatgt 3606841 ctttgctgtt caaacagctt tacagccggc aagggaaaaa ggacgccatc cgcattgccg 3606901 caggccttgt cattctggcc gtgtttgaaa tcgggctgat ccgccaggcc ggcattgatg 3606961 aatcggtgtt gcgcaaaacg tatatcatac tcgcgcttct tttgatgaac acatatatgg 3607021 tgtttctttc cgtgacatca caatggaagg aatcttatat gaagctgagc tgcctgctgc 3607081 cgatttcttc acggagcttt tggctcgccc agagtgtcgt tttgtttgtc gatacctgtt 3607141 tgagaagaac tttattcttt tttattttac cgctgttctt atttggaaac ggaacgctgt 3607201 caggggcgca aacattgttt tggctcggca ggttttcgtt ttttaccgtt tactccatta 3607261 ttttcggagt tgtgctaagc aaccacttcg tcaaaaagaa gaacttgatg tttctgctgc 3607321 atgcggcgat attcgcctgt gtatgtatca gcgccgcttt gatgccggcc gccacgattc 3607381 cgctttgcgc ggttcatatc ctgtgggcgg tggtcattga ctttcctgtc tttctgcagg 3607441 cgcctccgca gcagggcaag atgcattcat ttatgcggcg atctgaattt tcgttttaca 3607501 aaagagaatg gaaccgattt atctcttcta aagcgatgct gttaaattac gcggtaatgg 3607561 cggtattcag cggcttcttt tcgttccaga tgatgaacac cggcatcttc aatcagcaag 3607621 tgatttatat cgtgatttcc gcgcttttgc tcatctgctc gccgatcgcc cttttgtatt 3607681 cgattgaaaa aaatgaccgg atgctgctca tcacgcttcc gatcaagcga aaaacgatgt 3607741 tttgggcgaa atatcgcttt tattcaggcc tattggcagg cggatttctc cttgtcgtga 3607801 tgattgtggg tttcatcagc ggccgttcga tttcagttct cacttttttg cagtgcattg 3607861 agttgctgct ggcgggagcg tatatcaggt taactgcgga tgaaaaaagg ccctccttca 3607921 gctggcagac ggagcagcag ctatggagcg gtttctcaaa atatcggtct tatctgtttt 3607981 gtcttcccct attcttagcc atattagccg gcaccgctgt atccttggcg gtcattccga 3608041 tagccggtct ggtcatagtc tattacctgc aaaaacagga tggtggtttc tttgatacaa 3608101 gcaaaagaga acggcttgga agttaacctg ctgaagactc atcaattttc aactatttca 3608161 atcgccgcga gctttctgaa accgatcgaa agcgcggcgg aacctgagga agaaacgatt 3608221 tatttttacg gcgccgccgc atacctgaag gagcaaatca ttgacgcttt tggttatgct 3608281 gccggcagcc gtttcatgta ctcagcgaat ctcttttttg atcagcagct gaaaacctgc 3608341 gggacccgtt tgattcaccc attatataac gggaatcttc atgttgacgc cctgatgaaa 3608401 acttttgcag acttgtcttt cccttcttct ctttcattcg aagcatttga aaaggccagg 3608461 aatgagctgc tgctgaaaat cgaaaagaaa ttcactgatc ccttctccta ctcggcggct 3608521 cgcttggctg aggaggtctt cggaaacccg atgtacggca caggcatgtt tggccggaga 3608581 gacaggataa aggcgattca tcctaaacgg tttctcgacg caacggactt tatcgttgat 3608641 ttagtgtccc agcaaaaaca gctgaacata ttgggacaag tacaagcatg tgatgttcgg 3608701 ggacatgccc cgcaaacgtc cgctgtaacg tccggaagaa tacccgtaaa ccggcatgtt 3608761 tttgaaacag agacacgcag cgctgcaggt ccttccgtct tgacactcgg atttgactgc 3608821 ggagagatga aagatgccag cgattatatc aaaatacagc taatagacgg attactggga 3608881 aagtacggcc attccgcttt attcaagcac ttcagagaga aggatctggc agtctatcac 3608941 gttatcaccc gttacgatgt catgaacaat ttgctgcttg tttcaatatg tacagatcag 3609001 cttcatgaga aagacattcc cccgcgcgtt ttggaagctg tctcagcttt tcatacagat 3609061 gagcgggaac tagaacaggc aaagcagttt ttacgcaatg aattgctgct gcaattcgat 3609121 tctcccgaag gtctattggc ctatatgggg gtcctgcgcc gcttctcctg cacgaaagaa 3609181 gccttgctgg atggcatctc agcggttaca tgccgtgatg tattgcaatt catagcgacc 3609241 atcaattata tcggagctca tgtagtaagg ggatgaagag atggaaaaga aagccttttt 3609301 tcaacagctg gatgaacgaa ccgatatcag atacacagac agcggactaa aaatattcag 3609361 attgaaattc ccccgcgccc acctgcggct gtgcaatgta aaaatcgatt ttggaagccg 3609421 ggatgtatgt atacgggcag aatccggtga tacactgctt ccgtatggca cagcacattt 3609481 tttagagcat cttctcttct ggcataacgg ccgcaatctg tacagtgatt tttttgcgca 3609541 tggcgcgctt ttaaacgcat tcactaccta caccgatacc aatttcatgt ttacctcatt 3609601 accggatcgg ctcagacaaa cgattcccat cctgcttgat gctttatgga accactcatt 3609661 tgacaagaag attgtcgctc aggaaaaagc tgtgattaca agcgaaattc aaacagcaca 3609721 ccttaaccat cagctctcat atcattatca gctgatcagc atgctttctc cctcctcacc 3609781 agctgccgtt ttccccgcag gcagaatcga agatattgag gcgctggaca tcagtgattt 3609841 acaaaaagcc tataaggctg cctaccaagc ccatcggatg acgctgtttt tgattggggg 3609901 ctcagaaaat acagaaacgc ttttgcctcc tcacctccag ctggaaaagc gtccggatta 3609961 tcatgctgaa agaaaaatca tcccggcatg ccctccagtc ctctcacaaa aaatgatgct 3610021 gggtgatgag gagcggatgg aagatacctg gaccggatta cagatcggcg cacttcccgg 3610081 gcaaaacgat ctgttgtcga taaagcttta ttgggatatc gcggctcgta ttctatttca 3610141 attagattca ccgttttttc aagagattca gcaaacgtac cgcctggaaa tcgatcgctt 3610201 gtcagccgag acttatatat atgaggatgg cggtttcttg atccttcaca gtcaagggac 3610261 ccattcttca gcttatatcg atgtggcttc atactatgtc acacagaaga aagaacaggt 3610321 tgccgcctgg cttcaatacg gcaaggactc tttgacagac gcgatcattt atgacagcga 3610381 ttatgtgcgt aaatgcttcg agtgggcagc cgagtgtgac aggtgcgatt gctcgtttct 3610441 tgacatgtac cacatcattc aagatatgga tgcgcaggtt ttcttgtctc tcattgatgc 3610501 aatggcatct tctaacaaag cgatcattca cgtttctcag aaagaggcga tcagacaatg 3610561 aaacaaagca ctgtctttac ccttttattg ctgcttatag gtatggcggc ttattccttc 3610621 ggctgggttc aggccgttgc cgaagccgcc gcccaatatg tacagatgat caacaatgat 3610681 gctgtgcggc tcggactgct ggcttgtacc gctgccctcc tgatgctgcc tgcttttctc 3610741 tatcttcact atgtcaccca atccgtgaaa aacatgacag cagcttttca gaaactcaca 3610801 cagtctcatc aaagctgctg tgactttcag caacacaact tgtgcagccg atatgcagaa 3610861 gacgtcaaat cgctgcgtga cagctataaa aacgtccgcc aaacatacgt gatggctgcc 3610921 gtgttgtgcc aagtcatcat attcggctgc atgttcgaaa tcgttaaagc cgtccctttc 3610981 cgccttcata cgccccctgc cttttcaatg ggacttgcga tgctactgat cctgtattta 3611041 ttgttttgca tgcgaacgta tttgcggcag cttttccggc acggcagcct gttcagaaaa 3611101 gtgtttgcgg gagcactggc agcagccggg atttggtgga tgctcagttt ctctataagt 3611161 gaactgctgt ttctgattat cctggctgcc attcagcaaa tcggatcatt tatttataaa 3611221 cgattctctt atcacagcac cgcttctctt gatctataaa atagctacat cgcaatcgca 3611281 gacggacccg cgccaaccgg aatcaccgtc acggctgtat aatcacttgt gcggtacacg 3611341 gtcacagcat tgtcgttggg ctgtgccgca taaatatact gtttgtccgg cgttacggcg 3611401 aggtcaaagg cgccggggag agacacgttt gcaatgatcc tctgtctggc cgtattaact 3611461 acgtataagt tattaatgag aaacggttca ctatatggct ctagaaaata agctctagta 3611521 ctatcgagag aaaatacaat cgtcctcagc gtttcaaata aacggctgaa gtcccctccc 3611581 ctgcttaatg gtgacaaact aatctccgtt acacctttcg gccacagctc accattcaat 3611641 acgtacgcaa aatttccagc gtaaggagtt gtaattaaac tgggaaattc aaatgtatct 3611701 atgatacttt ctaccaactg cccagtattt acatcatatt tatcaaccga ccaactgctt 3611761 ccattagcgg tatagacata ctgtccattc ggatcaagag caaagtctaa agcgccgggt 3611821 atcggaatga catcaatgac cgattgagag gccgtgttaa tcacatatat agatccggcg 3611881 gccatcacgt atgcgaactc atctgttgga tcaaattcga tttttctcgg ccctcctcca 3611941 acagtaatgg tatttatgat ggttaatgtt ttattatcaa tcactgagac aaggttggta 3612001 tttccatgga ggacatacgt gaatgcttta tcgaaagtaa cgcctagatt agttggcacg 3612061 tcagaaaaag ggattgtttt tacaacagtg tttaaatctg catcaataac cgaaaccgtg 3612121 ctgtctccag tattggcagt aaacacatac gattgagggt ctggtgatgg cggtaaaaca 3612181 agtgtcccgg ccaccgtaag cggactgccg tagaaaggcg gtacaatgag cagatcttcc 3612241 actgttattt gactgaaatc aggacagcgg ccagactgtg ctgcataata aacaacttga 3612301 tcaatctctt cagtatgaat cacagaaaca gccccgtctc cttgtccata ttgatttcgt 3612361 acaggcgaca cactgacaag aagcgtaatg gtcccttgta ctctcacagc atatcgaaca 3612421 ccgatatctt ctggttccgg cccagtctgg attaagcaag gctcactgat acaggacaaa 3612481 ttgtctgtac tccatgtaac agccgctgac gcttcggccg tatcaacctt gaagccctca 3612541 gggaaatcta tcggcacttg aaacggcgct tcccggctaa tttcctcatc acaaaaacag 3612601 aaacaatttt cctgtaaagc agaaagatca ttctttttca tgatttcacg tccttttaga 3612661 aatgcacaac atgcagcggt taaatcgtaa tggcacccgg tgaaacccca agagatatca 3612721 cagtttcctc agaataatca tctgtgttgt aaacaatgat gctctgctct ataaaacgag 3612781 ttgcatacag aaaatcgcca ttcggggtaa acgcatagtc tgttgctgat tgcggaacat 3612841 ttcctataac gcctgctcca tttggactga cagaatataa attgccagtg aagccgtcat 3612901 ataaatacac ctctgctcca ctcgtaaaca ttcgatattc cccttcatac tccagctctt 3612961 gggtgctgct gatggtaaac gtatttaaat caataaccgt caaataatta aaaaagaatt 3613021 cttgttctaa tacataggca taccgctccg gccaatttgt ttctatggtt gatacgataa 3613081 gctctcgttc aattgttcct gtgacttcac cggtagttag gtccactttt tgcactattc 3613141 caaaattcag aacataggcg aataacccat tgggatcgat tgcaacatca tatccttcca 3613201 caggaatcga cctatccaca gttaacgtat caattccaat cacataaacc gcagtaccgg 3613261 tgaaaacata agcaaactca tgattaggga taaatctaat caatcgaggc ggctgatcca 3613321 gcaatatagt tgctgtcact gttaatgtgt cataatcgat gacagaaatc acattattgt 3613381 tgggatgtaa gacaaacaca gcgcttttat ctggcgtaat ttcaatacct gccggattgt 3613441 acggaagagc aatcgttgtc acaacagtat cggtgtttgt atcaatcaca gaaactgatt 3613501 gatcatttgg attcgctgta aacgcgtaga cgggttccgg ctccggtaca agcacaattg 3613561 tccccgtcac cgataaagga ctgccgtaaa acggcggaac aacaacaagg ttctcaatcg 3613621 tgatgtcact gatatccggg caatcatccg attcatcgga ataatagacg acttgatcga 3613681 tttctgcatt gtgaatgacg gaaacagccc cgtccccttg tccatattga tttcggacag 3613741 gtgagacact gacgagtagc gtaacggttc cctgcaggcg cactgcaaat tgaacaccga 3613801 cctcatcagg ctcaggcccc gtttgaatta agcaacggtc actgacacaa gaaaggctgt 3613861 ctgcattcca cgtcacgttt gcaacagctt cagccggatc aacgacaaac ccttcaggta 3613921 attcaatcgg tgcttgaaac atggcttctc ggcttgcttc tccctcacaa aaacataagc 3613981 actcttcttg ttctgctcct gctttttctt taaaggaaag cttgtttttt ctcattcctt 3614041 cacttccttt tcagacatac actgctcacg cagatataac agaatatgga agggtaacgt 3614101 gtttgcttgt acaaattgct gagggtaaac gcttcttttt gaaaatatat ctccaaacat 3614161 gcggtgtaac gaaagaaaaa attgcggttt ttttgcgctt ctcacaagaa tgttgatgat 3614221 aaaatatgac atatatagaa ttatgaaggg agggatttgc aaacgtgaca ggtgtcatat 3614281 cttcttcttc catcggagaa aagattaacg aatggtatat gtacatacgc cgattcagca 3614341 tacccgatgc agaatatttg cgacgagaaa tcaagcaaga gctggatcaa atggaagaag 3614401 atcaagacct tcatttgtac tattcactga tggagtttcg gcacaaccta atgcttgagt 3614461 accttgaacc gttagaaaaa atgaggattg aggaacagcc gagactgtct gatctgctgc 3614521 ttgagattga taaaaaacag gctcgtttaa ctggtctgct tgagtactat tttaacttct 3614581 tcagaggcat gtacgagctg gaccagcggg aatatctgtc ggctattaaa tttttcaaaa 3614641 aggccgaaag caagctgata ttcgttaagg atcggataga gaaagctgag tttttcttta 3614701 agatgtctga atcttattac tatatgaaac aaacgtattt ttcaatggac tatgcacggc 3614761 aagcatatga aatatacaaa gaacatgaag cttataatat aagattgctg cagtgtcatt 3614821 ctttatttgc caccaatttt ttagatttaa aacagtatga ggatgccatc tcacattttc 3614881 aaaaagctta ttctatggca gaagctgaaa agcagcccca attaatgggg agaactttgt 3614941 acaatatcgg gctttgtaaa aacagccaaa gccaatatga ggatgccata ccttatttca 3615001 aaagagcaat agctgttttt gaagaatcaa atattcttcc ttccttacct caagcgtatt 3615061 ttttaattac acagatccat tataaattag gaaaaataga taaagctcat gaatatcata 3615121 gtaagggaat ggcttattca caaaaggccg gagatgtaat atatttatca gagtttgaat 3615181 ttttgaaatc tttatactta tcaggcccgg atgaagaagc aattcaagga ttttttgatt 3615241 ttctcgaaag taaaatgttg tatgctgatc ttgaagattt cgctattgat gtggcaaaat 3615301 attatcatga acgtaaaaat tttcaaaaag cttctgctta ttttttgaag gtggaacaag 3615361 taaggcaact tattcaagga ggagtgagtt tgtatgaaat tgaagtctaa actattactc 3615421 tcttgtctgg ctctaagcac tgtgttcgtg gcaacaacta ttgcaaatgc acctacacac 3615481 caaattgaag ttgcacaacg aggaatgatt taaccgccgt ccatcggcgg ttttttcgtc 3615541 ccctctttac caaagtctcc caatccatgc tatgatcttt tcaataatct tgaagagagt 3615601 ggaaatgcag catgtctcta aaaagtgtga gaacccactt tactcaatgg aatcgagaaa 3615661 atgatgtgac ggagttcgaa acgtcgagtg cgacagttga acaggcagct gagacaatcg 3615721 gcgtaagcct gtctagaatc gccaagtccc tgtccttcag aggggaagga gatcaggtga 3615781 ttctgattgt ggcagccggc gatgccaaga tcgacaacaa aaagtccagg caaacatttg 3615841 gctttaaagc aagaatgctc tctcctaatg aggtgctgga gcagacaggc catgaaattg 3615901 gaggagtttg cccatttgga ttggctcatg atcctgaggt ttatcttgat gtatcgctga 3615961 aacggtttca gactgttttc cccgcatgcg gcagcagaaa ctccgctatt gaattaacac 3616021 cgaaagaatt atccgaattt tctttctcaa aagtgtggat tgatgtttgt aaagactggg 3616081 aataaaaaaa catccagaca tcgtctggat gtttacttat ttcacaaacc caagcagcat 3616141 ttcacggatg attttgctgg ctgtgtttgc cgtttgctct gagtggtcgt ataccggcgc 3616201 gacttccact aaatcagcgc cctttacgtt tacctctgaa cgcgcaattt catggaccga 3616261 tgcaagcagt tctttagacg tgatgccgcc ggcgtcaacc gttcctgtac ccggtgcgtg 3616321 tgcagggtct aatacgtcaa tgtcaattgt gacataaacc ggacggcccg ccagcttcgg 3616381 aagcacctct ttcagcggtt caagcacttc aaattttgag atgtgcatgc cgttttcctt 3616441 cgcccattca aactcttctt tcatgccgga acggattccg aatgaataca cattgtgcgg 3616501 tccgatcaat tctgccgcct tacggatcgg cgtggagtga gaaagcggtt ctccctcata 3616561 atcaacacga agatctgtat gtgcgtcaaa atggataatc gcaaggtctg ggtatttctt 3616621 gtacatcgct ttaatgacag gccatgacac gaggtgctcc ccgcccatac ccattgggaa 3616681 cttccctttt tctaaaatgc tgtccacgta ctcttcaatc atatccaggc ttcgctgcgg 3616741 atttccgaac ggcagcggaa tgtcgccagc gtcaaagaag ttcaagtcag ccagatcgcg 3616801 gtctaaatat gggctgtatt cctcaaggcc gattgacacc tcacggattc tgcttggacc 3616861 aaagcgtgag cccgggcgat agctgactgt ccagtccatc ggcatgccgt aaagaatggc 3616921 gtccgcctct tcccactcgg gacggctcgc gataaatact tttcctgaat aagcttcatc 3616981 aaatctcatc tataataccc tcgctttcct gtaaaaaagc gcaagattcg ctcctgcgcc 3617041 ataccttcat tatttaatca ggtcactcac aaatttcggc agaacaaacg ccgctttatg 3617101 aatatctttt gtgtaatatt tcgtctcaat atcgaagaaa cggctgtctt ccactgcaag 3617161 cggatcatat tttttcgagc caattgtaaa tgtccacaaa ccgcttggat atgtcggaat 3617221 gttcgccgta tacagcttcg taatcgggaa gatttccttc acgtcgcgct gtacatttgt 3617281 gattaattcc ggtgtaaacc atgggttgtc cgtctgcgca acgaaaatac cgtcttcttt 3617341 cagcgctttt gcgattcctg cgtagaatcc ttttgtaaac aggtttacag ccggtccgac 3617401 tggttcagtc gaatctacca tgatgacgtc atattgattt tcagattttg caatgtgcat 3617461 aaatccgtca tctacctgca cgtcaacgcg cggatcatcc agtttgcctg cgatagaagg 3617521 aaggaacttt ttagagtatt cgataacctt gccgtcaata tctacaagtg tcgctttttt 3617581 cacgcttggg tgcttcagga tttctctgat aacgccgccg tcaccgccgc cgactacgag 3617641 aacgtgctcc ggatttgggt gcgtgaataa tgggacatgc gccaccattt cgtgataaac 3617701 gaattcgtct ttttcagatg tcatcaccat gccgtccaaa aaaagcatgt tgccgaactc 3617761 ttctgtttcc accatttcta aatgctgaaa ctccgtttgt tctgtatgta acgtcttgtt 3617821 aaccttcatc gtaatgccaa agtttttcgt ctgcttctct gtgtaccaaa gttcgctcaa 3617881 ttgtcatctc cctttcgagg ctgtattcat ttattgtaag cgtcttatca gcttttattc 3617941 tcggttgaaa tctcattttc acctaaggaa aaagtataga ggatggcggg gaaaaagtaa 3618001 agatgcgtcc tgttctgcga tgtttaaaaa cgatcttttt ttctcataat agtagaaaca 3618061 taaaaaaagg gggaacccgt tgtggatgca atgacaaata aacggctgag actgacgctg 3618121 aaaaccgttc gcgcctttat ctttttaggg gcttttgcgg ccttggcggc agctgctgtg 3618181 tttatgactg tcattttgat agccaaatac cagggcgctc cctcggtgca agtgccgcaa 3618241 tccacgattt tgtacgcgag tgacggctca aagctcgggg aaacgaacta cggcgaaaag 3618301 cgctattggg tccccttaaa ggacatgaat ccgacgatcg taaaagcgac agtggcgatt 3618361 gaagaccaga atttctacga tcatcacggc tttgattata aacgcatggc cggcgcggcg 3618421 cttgctgacc tgaaagcatt tgccaaggtt cagggtgcaa gcaccatcac ccagcaatat 3618481 gcgagaaact tataccttga acacgacaaa acgtggaaac ggaaatggaa tgaggcgttc 3618541 tacacgatcc gtctggaaca aaactattct aaggacgaga tattagaagg ctatttaaat 3618601 acgatttact acggccacgg cgcctacggc attgaagcag cttcccgcct gtatttcggc 3618661 aagcatgcca aaaacctgac ggatgcggag gcggcgcttt tggcaggaat cccgaaaggc 3618721 ccttccggct attcaccgta tgtcaatgag acgaaggcca aggaacgcca gaaaacgatt 3618781 gtgcggatga tggaaaagca gcagatgatc agccaaaaga aagcggatga attgatcaag 3618841 gaacctcttt cctatcagcc tttgaataaa caagtttcca agagaaaggc tccttatttc 3618901 tacgacaatg cgatgagaga gctggaaaaa aagctcggca tgacacggga gcaaattgaa 3618961 acgagcgggt taaacgtcta tacaacggta gataaacgga tgcagcgcat cgccgaggag 3619021 accattaccg aaacggttaa cgcgggctct gacattcaag tcgggttttc agccattgat 3619081 ccccgcaccg gaaacgttct cgcccttgtc ggcggcaggg attatcaaaa aagcccgttt 3619141 gaccggacga cacaggcgaa gcgccagcct gcttcgacga tcaagccgtt gctgtactat 3619201 aaagcgattc agagcggatt tacgccagtc actttgatga aaagcgaaga aaccgagttt 3619261 caaattgatg caaagggaga aacctattct ccaagcaact ataacggata ctatgccaac 3619321 aagccgatta cgcttctgca ggcgctggcg ctttccgaca atatttacgc tgtgaaaacg 3619381 catctttttc tcggcacgaa caaacttgta aagacggcaa aggaattcgg cattaccgcc 3619441 catcttcaag cactgccgtc cctggcactc ggcaccgaac ccgtacgtcc gattgagatg 3619501 gtcaacgcct atgccatgct cgcaaatggc ggaaagaaaa tcgaaccgac ttttatttca 3619561 agagtaacgg acgcagccgg ccacgtgctg tacgaaaacc cgaatcagca taaacaggtg 3619621 cttgatgaaa aagccgcttt tgtcacagcg agtatgatga caggcatgtt tgatatcgat 3619681 ttaaatggat atacgtcggt tacggggcga acgatagcca accgcctgac aagaacgtat 3619741 gccggaaaat caggaaccac cagcgcagac agctggatga tcggcttcaa tccgaagctg 3619801 gccgccggtg tttggaccgg ctatgacaaa aacagcacca tcgactcggt cgaagaaaaa 3619861 agctatgcta aaaccatttg ggcggacttc atggaggacg cgctcaaagg cgaaccggaa 3619921 accgcgttca agccgccaaa aggcgtaacc ggtgtgtaca ttgatccgga aacaggctac 3619981 tcatcaggtc ccggctgcgc cgctaagcat tacacatatt ttgtgaaagg gacagaaccc 3620041 gcaaacgtgt gctacggggc agaacccgca aaacaaacaa aagaccggct tccatccaaa 3620101 gaaaagcccg cttccgagaa aaagtggtgg gacaaatggc tggggcgaca tcattgaaaa 3620161 taacccggct cctcggaggc cgggttattc gtatggttcc ttcataatcg atggaagaat 3620221 gttagacaat cgagctgaac aatcagtttt gggataaagt ggtgaatttc tcatttcttc 3620281 ggcgctggct ttcatctccc agtcgccgac tcatatcccc ctaaaaatga aaaaccccga 3620341 gtcttgtttc ggctcgggat tttccatgtc ctatttctgt atcaccagtt tactcaatgt 3620401 ttacgaaaaa tatctcaaat actttaaaag ttcacaaaaa attcataaat taattgtttt 3620461 ctggaagcag gctcgttttt aactcatctg aggaacggtc ccataggccc tgatcatgct 3620521 ttttcagaaa ttcgcctagt acacgcttcg agctgtcgtc cattttatca acgatgattt 3620581 tccgtttcat ggatttatcc atcagattca catgctcagg cagtgacttg tagcctcttc 3620641 tgatgcttct gtcgaccgtc atttcacagg ctgtcacacc agcgtaataa ggcccctctt 3620701 cttttctgtc aatcgttacc cacacaagcc agtatggttt tccgttcggc acttcttctt 3620761 tattcgggag aaatttaatt cctttttcaa cggtgctgcg ggcatgcata gcgccgatgt 3620821 ctacgaacgc ttctttttcc tctacatcaa cgaatacggg agaaatgtta tcaaggctga 3620881 gtgcccctac gccaaaaccg ccgtgtccgt ctgtcggatc acttttgata atattaaacc 3620941 cgattgattt tttctttttt tcttccatga agttctacct cctacaaaag cggttgaaat 3621001 atcgctgaaa acagctttaa aatcgaatct cttcctgcat tgagcatcgg ccacagcacg 3621061 taagatccta gcggtgtcac aaacagcacc aaaaatacga taaagccgta gctctccgcc 3621121 tgcgtcattt tggcacgcac gcccggcgga acgagatctt ctataattcg atagccatcg 3621181 agcggaggaa gcggcagcag attaaataaa aacaagacaa gattcagctg tatccaaata 3621241 gaaaaaaact gatccagccc cgtgctgaac gccgcaagca tttccattcc gtacgcatgc 3621301 atcaacacta acaaaaagaa accaataaac gcaagaatca ggttactgac gggcccggct 3621361 atagatacga gcacaccagc aagccggggt ttcttaaaga aacggcgatt cacgggaatg 3621421 gggcgcgccc acccgaatcc ggccaccaga atcaaaatgg ttccgaacgg atcaaggtgt 3621481 ttaatgggat tcagcgtcag tcttccttgt tttttcgccg tatcgtcacc gaatttgtat 3621541 gcgacataag cgtgggcaag ctcgtgcatc gtaaacgaca caattagcgt gatgacgagg 3621601 tatggcatta aagataacgg ataatataaa aaacggtcca agtgagatat ccctctttct 3621661 caaaatgcaa gaatttactt tattcagtat actataagaa gcctcttttt ctaaagagag 3621721 gaaacgagat aaaggaggat tcagcaccca tgccatacgt aactgtcaaa atgctcgaag 3621781 gccgtacaga cgagcaaaaa cgcaatcttg tcgagaaagt aacagaagcc gtaaaggaaa 3621841 caaccggtgc ttctgaagaa aaaattgttg tctttataga agaaatgaga aaagaccatt 3621901 atgccgtcgc aggcaaacgc ctgagcgata tggaataatc tctataaagc cggcgcttcg 3621961 cgcaccggct tttattatcc ctattgagcc agcttcgcaa taatcgccaa gaacgtcttt 3622021 ttctcttcgg ctgttaaacg ttcaaacatg ccatcaatca gctgctggcg gttttcgatc 3622081 atttgttcag ccgctccccg gcccgattca gaaagagtaa tccatacagt gcggcggtca 3622141 ttgttatttc tggatctctc aataaaccct tcctgctcta aatgattcag agctgtggtc 3622201 gtggcagagg gagacagtgt gacctccttc aaaatatcct ttatggtgca gctcccatgt 3622261 ctgtatatga tccgcagaat aaaccctctt acattattca cgtgtttcgg aacggtggct 3622321 tcatctaatt gcttcgtgct tttcaaatac tttgtaagtg cgtgatccag caaatttgct 3622381 tccagtttgt catggtccat gtcaatttcc ccatttcgag atgcattcat aacatacgaa 3622441 cgatatgatt tacttattat tttactgatt ccgaataggg aaagtcaaaa aagcaaaatg 3622501 tgaattcaca gcttttatcc tacatgcctc gattttccac ctgtttcaca agtttatctt 3622561 taaaagtttg gaaaggaacg tgttcattct gctgatgtcc gaatcggcgg acgtttaccg 3622621 cattctcctg ctcctcatga tctccaagca ccagcacgta cggaattttt tgcacctgcg 3622681 attctctgat tttatagccg agcttctcat tgcgctcatc aatgccggct cttatccccg 3622741 cctgcttcag ctccgcctgc acttttctgc aatagtctaa gtgaacgtgc gaaaccggta 3622801 tgatttgaac ctggatcggt gcgagccaga ctggaaaagc cccaccgtaa tgctcgatca 3622861 aaatgccgaa gaaacggtcg attgagccga aaaccgctct gtggatgaca acgggacgaa 3622921 ccttctcatt gagttcgttg atatatgtta aatcaaattt ttccggcatt tgaaaatcaa 3622981 gctgaattgt cgcgcattgg tggctccgtt tcagggcatc ttttatatgg aaatcaattt 3623041 tcggcccgta aaacgcccca tcgccttcat tgatctcata agagaggcca agctcctcaa 3623101 ggacgcgtgc taaggcacgt tccgacgctt cccaaaggct gtcatcgcct aatgaatcct 3623161 ccgggcgagt cgaaagctca acagaatact cgaaaccaaa tgtccgatat acctcatcaa 3623221 tcagccgaat cgcttctttg atctcactct caatctgatc ctcccgaacg aaaatatggg 3623281 cgtcatcctg acagaacgtc cgaacgcgaa gcattccgtt taaagcgccg ctgtattcat 3623341 ggcggtgcac ctgtccgaat tccgccatgc gaatcggcag atcccgataa gaatacaggc 3623401 tgtttttaaa gatgagcatg tggccggggc aattcatcgg cttcattgcg aatcttgtat 3623461 catccacttc tgaaaagtac atattgtcgc gataatggtc ccaatggcct gactgctccc 3623521 ataaccgctg attcatcata aacggcgtac gcacctcatc gtagccggca tttgtttgca 3623581 gctcacgcga gaagcgctcc agctcattgc ggacaatctg ccctttcggc aaataaaacg 3623641 gcatccccgg cgcttcttca gaaaacataa acagccctaa ctgtttgccg agcttgcgat 3623701 ggtctcgttt tgccgcttct tctagcatat gcaggtgcgc atccaaatct tttttctttt 3623761 gaaacgcaac cccgtacacc cgctgcagga cttcattttt gctgtctccg cgccaataag 3623821 cgcctgatac tcttgtcagt ttgaacgcct tgatcatccc tgtagaagga agatgcggcc 3623881 ctcggcacag gtcaacgaat tccccttgct ggtacagtgt gatatcctcc ccgcgcggaa 3623941 tatcctttaa aatctcaagc ttgagccgct cgtctttttg tgcaaacagc tcttcagctt 3624001 cttcgtaaga aacctctata cgtttgattt caaggttctc atttattatg tttttcattt 3624061 ctttttcgat ggcctctaag tctcctgatg ccaagctttt ccccagcttc atgtcatagt 3624121 agaagccgtc taaaatcaca ggccctaccc ccaatgacac ttcgccgtac agccgtttta 3624181 ctgcttgggc cagcacgtgc gctgttgtgt ggcgaagcac ctgcaagcct tcttgtgaat 3624241 cgagtgtgac aatcgaaagc tcagcatcct cctccagctt gaaactgaga tcaacaagct 3624301 tgccgttgac ctgacctgcg gccgccttct tttgcagact ggaactgatc gaaccagccg 3624361 cttctttgat tgtgatgcct ttcggatatt cctggatctg tccgtccgga agctgaatgt 3624421 gtacatgttt gctcatttta gaacactcct tattcattgt tgtatataaa aaaacacacc 3624481 cgtcccgcag atagggacga gtgtgtgatt aacccgtggt tccacccaag ttcccgacaa 3624541 atactatgtt gtcggctcgg tgctgtaacg cagcatagac ggcattggtt acttcagttc 3624601 cccaatgctg ctccaaggcg gtaaatgata ttcctaagct gggaagctct cacctttcct 3624661 tccctctctg aaaaccgtaa ctatcattca tgtccttttc atcgcatgta ttcaattcat 3624721 aaaaaaacac acccgtccca cagataggga cgagtgtgtg attaacccgt ggttccaccc 3624781 aagttcccga caaatactat gttgtcggct cggtgctgta acgcagcata gacggcattg 3624841 gttacttcag ttccccaatg ctgctccaag gcggtaaatg atattcctaa gctgggaagc 3624901 tctcaccttt ccttccctct ctgaaaaccg taactatcat tcatgtcctt ttcttcgcat 3624961 gtattcaatt caaataaaaa aacacaccca tccctctaaa agggacgaat gtgttgatca 3625021 tccgtggttc cacccaaatt cccgatcaat tacacatgat gatcggctta aagatgctgt 3625081 aacgcagcat gacggtatca gatacttgtt ttccctgata cggctcaaag gcggtaagct 3625141 gctttccctg cgttaggaag atctcagctg tccttccctc tctggaaacc gtaaaaagca 3625201 tctcgtgtcc ttatcagtgc ctgttgtttc aataattttt tatatcttac tatatattcc 3625261 cacaaagcgc aatcagtgat ttacattttt tctgacgcgg cagtcccgtt atgggcagcc 3625321 agaaacagcc atacaagcaa tgcagcgagg ctgtatgccg ctcccatcat caaaaacgca 3625381 aacccggcac cagcatacca agtggcggac agatgaatga tcaccccggt tatcgctacg 3625441 ccgaccaagg ctccgatttg ccggtttgca tttaacgccg caccggcgat attcgtatgt 3625501 ctttgcccgg cagcctgcat gatcacagtt gtcatggcag gaactgtaat accggtacag 3625561 aggttcataa cagacatcaa caccgccagc tgccaataag gaaaatccgg agaaatcagc 3625621 acaaacaaca gcaatgcaat gatacagctg accgccattg atacaaacat aagctgaccg 3625681 gcttcaaacc gattcgccag acgggcaaac agcagattgc cgatcacgaa gaccgccatc 3625741 atcggcagca gctccactcc agccataaag gaacttgccc ctcctgcttc ctgcaaaaaa 3625801 aggctgagca taaacatgcc gccaaaaagg gcgaaattca gcaaaaaccc gataaattgg 3625861 gcagctgaga agcggccgtt tttgtataag gacgccggca ggatgggtgt ttttgcagaa 3625921 atttcccgca gcaaaaacag cacaaatgcc aaaaccgctg cagtaaatgc tacaagaatc 3625981 actggcgagc gccagcccgc tgaaggcccc tgtatcaaag cataggaaag aaacccgaga 3626041 gccatcatgc caagcagatg cccgatgatg ttcacgcggc tgcttttccc aggaacgcgg 3626101 ctgaggattc ggtaagctga aatgagcgca gcagccccta ttggcacatt gatcagaaaa 3626161 atactctgcc agcccgccaa ctgtaccagc acgcccccga taaaaggccc aagggctgaa 3626221 gcggcggaaa caagcgcggc ccacagtcca aacattctcg cccgcgcccg ctcatcaagg 3626281 taagaggcag ccaaaaggct gagtgagctt ggcataaaca aagctgcccc aattccctgt 3626341 atgagacgtc cggcaatcag catctgccca tttatagatg cagcgcatag acaggaggcc 3626401 ataacaaaaa cggctagacc caagatatag atcgtcttcg agccgaaacg gtcagccaag 3626461 gctccgcccg ccagcagaag cgacgcaaaa gtaagaatgt acccgtccac aacccacgtt 3626521 acacctgaaa gtgacattga aagagtgttt ttcatatcag ccatcgccac attcacaacg 3626581 gtcacatcaa gagttgccat gaggaaacca agtgcgagca cgatcagcac ggatatgcct 3626641 gttgatgatg ttgattcttg tatagacccg ctatttttca ttacaattgc cctttcactt 3626701 gcttgattac ccaatcatct attttttcaa gatcatacaa ttccccgact ctgtccataa 3626761 catgctgcaa ggattcttct ctcataagat tggaccattt atcctcgatt tccgccatga 3626821 ctgtctccag cacacagtga ctttcaccct caaatacaga ttgcagcaag cctttcccct 3626881 gatacatcga acctctgcct tcgaccgctt gataaacatc ataaagcgta atgtcagcca 3626941 aaggcttcgt cagggtaaaa ccgcccttcg tccctggtaa ggattctgcc aaaccggctt 3627001 gaaccaatgt tctcatcagc ttcttcaagt aagacggaga cacgcgcaat cgctggctta 3627061 tagcctctga cgtcaaagaa gcctgtaccg gcagccgtga cagtaacagc agcacagaaa 3627121 ccgcctgctc cattcctgat ttcattttca tcctattcac tcctgattca ttatggataa 3627181 ctattatcca taatgaatct cttagcagct tttgtcaata aaaaaagcaa aagaaacgga 3627241 tcatttcttt tgcttggtat ggttaacaaa tctgcttcag ttcctctatg tattgaagcg 3627301 cttcgtcata ttcttcattt gtatattttt gcttgctttt gatggtaaag actttttctt 3627361 tcttttcctc atcctcaagc ccgtcaaagt aaaggatcgt ggaaaccagc tctaaaaacc 3627421 gtgatgaacg gctgtttaca ctgtcgatat agcctttcat atccggcatg tccagatcag 3627481 catggtctaa aaatgcggag cctgtctcag tcagcgaata ccggtattga aagtagccgc 3627541 cctttttttc cttcacctca tgcagaaatc caaggttgca cagctcttca atctggagcg 3627601 tcagttcctc tgaatatggt ccgtaaaagt gaaaatcata tttctcatag aaaggaaact 3627661 gcattttctt ggcgatataa atcattttct gcagcttctt tcgcccgatg atttctccag 3627721 aatccgagaa caccttcatc agttttgcat gttctttcaa caaattcccg acatctcctt 3627781 tttccttctt tccaatttct atgtcagtcc cagcagctgc cggattttca ttttcgcttc 3627841 cggatgttta gtgccgtcac aaatcaagtc ctttggatag tacagcttgt ggtccgtccg 3627901 ccgtttacct gagatggatt ccacaatagc cgactgtctg gacagctctt taatttggcc 3627961 gttttgcgtc aagagatgga tcggcagacg ctcctcttcc tctcctggtc ggtaaaaatc 3628021 gtatggcaga tctgatgaag aatcaacgac caaataatag ctcggatcga tccccgcctc 3628081 tttgaacaat gaagtcagct caaaataagc cgacatttct tcattcggat tgaattcaac 3628141 gtattggaaa agctggcggt taatgaatct gcggcacaag tcggataaaa tcgcgtcttc 3628201 ttcatcctcc caggcctgga agtaatacaa aataatagat tcatccagct ttacataatc 3628261 ctccagtgtc aattttcctt caaaaataga atagaaatga accggagcgt gagtgaagac 3628321 atagccttca tcgtgcagct gcttcgccct gtgaagaatc ttcgttaaaa tgacctctgc 3628381 acttctagtc acaggatgga agtagacctg ccagtacatt tggtaacggc tcatgatata 3628441 gtcttcgaca gcgtgcattc cgctttcttt aatgacgatc tgatcctcgc gcggccgcat 3628501 cacccgaaga atccgctcca tatcaaaatg gccgtagctg acgcccgtat aatatgcgtc 3628561 gcgctggagg taatccatgc ggtctgcgtc aatctgactc gaaatcaggc tgaccacttg 3628621 cttgttttta tatgttttgg caatgacttc agcaacatcc tgagggaaac ccgggctcac 3628681 ctttctgagc acctgattaa cctccgtgtc tcccaaaatg atacctcttg taaaatcctc 3628741 gtggtcaagg tgaaagacct tttcaaatga atgcgagaac ggcccgtgcc cgaggtcatg 3628801 aagcagcgcc gcggccaaac agagttcgcg ctcactgtca tcccattcag ggcggccttt 3628861 aaagacgtca tcaaccattc ttctgacaat ttcatagaca ccgagagaat ggttgaaccg 3628921 gctgtgctca gccccatgga acgtcaaata ggtcgttccg agctgcttaa ttctgcggag 3628981 acgctgaaat tcacgggttc cgatcaaatc ccatatcagc ttgtcccgaa catgaacata 3629041 gcggtgcacc ggatctttaa acactttttc ttctgataat tttccatttg gatacgccat 3629101 cgtcattccc tctttttttt agccgtgttt ctattatatc gactctattc tttgaaaaca 3629161 tccttgaatt tgcccggcga tttgttccat cttcatgaaa aacacatctt gtgaagcaaa 3629221 aaagcctgac ctgagggccg aggctaagaa aaaatatgtt tttacttttt tattttcttt 3629281 tttactttgt caatcagctc atcctctgtc ggagctgaca gcgggcgatt gttcacaaaa 3629341 gcaaatgatt ttttccgtcc gggcccgcaa taagattggc atcctacctc aacctttgcg 3629401 tccgggtcca cttctttcaa acgcggcagc aatgttttga tattagtggc ttggcaatca 3629461 tcacacactc gaaattcatt agccatgacg tacgcttccc ttcatttcta tgttcatcta 3629521 tgtgaataac ctaaaatcac gtttcaaaaa aaatcacatc acacttcatt ttacaaggat 3629581 tcgactgttc ctgcaagccg ctccatcctt cgtatctcct attctttcag ccaatttgta 3629641 taaatatttt ccaacctgga cattctaata ccatgaaaag aaaaatggga gttgagataa 3629701 atgacaaaac agcgacaaga cgcttggtca gaggaaaacg atctgctttt agccgaaaca 3629761 gtgcttcggc atgtgaggga gggcagcact cagctgaacg cctttgaaga agtcggcgat 3629821 aaattaaacc ggacatccgc agcctgcgga ttcagatgga acgcagtggt ccgccatcaa 3629881 tatgaaaaag cgcttcagct tgcgaagaaa caacgaaaac agcggatgag agcgctcgga 3629941 aacgggcagc ccgcgaaaaa aagattatta tatcagcctc ctgccgttga tcctgaaatc 3630001 attcaagaaa ccgctgcaga agagccggtt aaaacggaaa caccatctgt cgaaaatgag 3630061 caacctttaa tgtctggcga acacatgcct tttgttgatg aaagctttaa ggaagagtta 3630121 gctagtctat cacacttatt gtctcctcaa acgcctgcag ctgcgcctga gatgacgatg 3630181 aatgatgtga tccgcttcct gcagaattac gaaggcaatc acgagcaatc atcagcatta 3630241 aaaatggaaa acgagcgttt aaagaaagaa aatcaggaat tgcaaaacaa aacagagcag 3630301 ctagaggcag aagttcaaaa gcttgaaaaa gaccaaaaaa cgatccaaga agattatgaa 3630361 accttggtga aaattatgaa cagagccaga aagctagttt tatttgaaga agatgaacat 3630421 gcctctccgt ccttcaaaat ggaccggaac ggcaatttag aaaaattagc ggaatgacat 3630481 agaaaaatcc caaaacgggc agctgttttg ggattttcgc catgtgcaaa atcccctttt 3630541 ctattgagaa aagagaattt cctcattttg cagccggatc agctattctt gtaaaatgag 3630601 gccaagctta tgtgaatcta ttaagacatg tgagctgcct cggccgtttt ttgtttccga 3630661 ggcgcagcag aaatgaccaa aagccccagc atcataagcg caatgcccag ccacgaggaa 3630721 ggcgaaagca tttcccctat gaaaaacacg ccaagcaatg aagccgtcag cggttcagct 3630781 aaagacagcg tgaccgccgc cgaggccgga accccggtaa gccctttcgc aaacaaaaag 3630841 tatgcggcac atgttgcaat taacccgatg taaaggcttg ttcccagtcc tctaggggtc 3630901 aatatccacg agatatctaa ctgccataat agcggcgtca gcaagatggc gctgatcatg 3630961 aatacaacgg cggaggtcgc tcgcggaggc tgggttttca tcatcgcttt actgatgagc 3631021 gtatagcctg caaaagaagc acccgctcca agcgccataa gaacaccagc cacatcaatc 3631081 cgaacattgg aactgtcgga aaacagaagc cagcaacccg ctaaagccag cacagtcgca 3631141 atccaccagg agtttcgcgg gcgtttcttc aatacagccc attcgagggt cccggcaatg 3631201 ataggcgcac tgccgatggc aatcacagtt cccactgcaa ttcccgtttc tttaaccgct 3631261 gtgaaaaaca gcggctggta acacgccata caaacagcgg ctaaaaatac gagcggccat 3631321 gcccaatttt tcacgtgaag ctcccggctg atccaaaccg caagcagcat ggcgcttcct 3631381 cctattaata acctgaacgc tccaaatgcc agcggtgtgg cgctttctgg agccaatgcc 3631441 tgaacggttc ccgtggtccc ccagaaaaaa gccgcaatca atacaaaaag gctgtaaata 3631501 ttccccttca tctgcctctc ccctttaata tggatgctga tgtcatttta tcgtttttct 3631561 ttttgtcgtg gttatctgta tgtaagaagg acttatctga aaataagatt attgaggtaa 3631621 aatgccgctt gagataaaaa atgcatgccg gcatatacag ccggcatgcg aagaacgttc 3631681 acccaaatac ctttgcattc cgctcagcca tccggacgag gtttttctca aattccattt 3631741 cctcatcaat ggacagtcca gctgaataaa gatgggtgct taacgctttt aattccgtca 3631801 ataaagcgaa cattaagtct tgtacggaga tgtctttttg aagaagctca cttaaggacg 3631861 ccatcgtttc cggacgtatt tccggataga cgcctttttt atcgttttgt ttgtctttca 3631921 gcgccgcttg atagaatcgt ctgatcaagt cggccctttc actgccgctt ttatctgcac 3631981 agagataaat ttgaacagcg actccgccgc gaacgcgtct ctgagagatg ccggcgaact 3632041 ttttgccatt tatactgagg tcatagctgc cgggacaata agacccttca atttcatagg 3632101 cttcgatctt tgcgttgtac ggtctcagca ttcgtctcat cagctcgacc atcgcttcat 3632161 atcctttgtc tatatcgatg cctttctttt cgtcctcgaa tatgagagag atatttaaaa 3632221 caccgtcatc caatacgacg gcaagaccgc cggaattgcg tacgatcaca cggtatcctt 3632281 cgctctccag caaggagata ccatcctgca aaaacgggag gcgtgtatcc tgtattccaa 3632341 ggacaattgt atcgtggtgc acccatgagc gcgctgtcgc cggcgacacg ccttttccga 3632401 cggacatgca tagcgtatca tccattgcga aggattgctt cgcatcaaat aaagggccga 3632461 gactggattg gtcaatgact ctccatttcg gctgcatcag taaatcaatc ggttggtttg 3632521 ccatctatgt aaaacccttt catgttaggc ttattgaacg aaaactatta tatcatttca 3632581 gcagctgtga ttgataattg cttttcagca tcgtaataaa aatttcttta ttttttgtat 3632641 tctccatgag aggagaatga atgtaagaca gcttgcgctt taacgagaaa ttattaatat 3632701 gcagaattga aatttcgcgg tggatcaaat ccttacgcag cacgcttctg gatagaaccg 3632761 aaagtcccat gccgttaatc accgcttcct ttacaccttg attgctgctg atggtaaaca 3632821 ttgatttcgg ccgaagtcca tttgaactga gtacatgatc gagatattct ctcgtcccgg 3632881 agcctttctc tcttgtcacc cacgcttcgt tctgcaaatc gctgatcgaa atctctttcc 3632941 gcccggcgag cggatgctga tttggagcgg caatgcacat ttcatcctcc atgaacggtt 3633001 caatttccag ctcattctcg tttgtatgtc cttcaatcag cccgatatca gcctgaagca 3633061 tccgcacacg ctcgctgacc tcctctgtat tgccaatcat gacatctaga ttcagctctg 3633121 gatacagctt ttgcagctgg gccaatagcg gcggaagaat atactcaccg attgtaaagc 3633181 ttgcagctat tttcaattca cccttcacat agtgatgatg cgcatagatt tcagccttgg 3633241 cttgttcgta gagaaacacc atttgctttg ctctttgata taaaatgtct cctgtcggcg 3633301 ttgtcgtaaa gtgttttggc gacctgttca gaagagccgt ttgaaattct ttctcaagat 3633361 ttttgatatg cagactgacg ctgggctggg agatcatcag cttttccgcc gcttttgtga 3633421 agtttttttc ttctaccacc gctataaacg ttttcagcac gtcgtaatac aaaaacccca 3633481 cccctgtcat taatgaaata tatggttatg attagttttc tttattgtac tcatatcatc 3633541 cgtcttggta aagaagggct atacagaagc gcaaaaaagg cagccctcgg tcgagagctg 3633601 ccattgtctt caattttatt acagtgcttg cgccgctgta attaatgcga gattgtaaac 3633661 atcttcagcg ttacatcctc ttgaaaggtc gtttacaggc atatttaaac cttgcaggat 3633721 tggtcctacc gcttcaaagt tgcccaaacg ctgagcgatt ttatagccga tgtttcctgc 3633781 ttcaagactt gggaatacga atacgttagc gtcccctttg atctcggaat ccggcgcttt 3633841 tttctcagct acagatggaa caaatgcagc atcaaattgg aattcgccgt caagtgtcag 3633901 ttcaggcgct ttttctttcg cgattttcac tgcatccgct actttttctg tttcatcaga 3633961 ttttgctgag ccttttgtag agaagctgag cattgccacg cgaggctcaa tgtcgaacat 3634021 ttttgccgta ttggcacttt cgatcgcaat ctcggcaaga tcttggctgt caggtgcaat 3634081 gttgatcgcg caatctgcga atacgtattg ctcttctccg cgagccatga tgaacacgcc 3634141 tgaagtcttt ttcacgcctt cttttgtttt gatgatttga agagccgggc ggacagtgtc 3634201 agcagttgag tgagcagctc cgcttacaag tccgtctgca agtcctttat acaccagcat 3634261 tgtaccgaag tagttctcgt ctaataatgc tttacgagcc tgttcttcag tcgctttgcc 3634321 tttgcggcgt tctacgaatg cttgtacaag gtcttccatg ccttcatatg tatgaggatc 3634381 ataaatctta acgccgccca gcgtaaggtt caattctttt gcttttgctt ggatctcatt 3634441 ttcattgccg atcacaatcg gattcagcac tttgtttcct gcaagcttgc tgaccgcttc 3634501 taaaatacgc tcgtctaagc cttcaggaaa tacaatttta acgtcttttc cagctacttt 3634561 ttcttgcact gttgaaaata aatctgccac aataaaacct cctcaaaaag ttacaaaaac 3634621 gctttctttt actagcatac tcttcttcca atcaaattca aacagccaac tttcattata 3634681 gcgctttcat aaaaaaatct tatttttcta actaatttaa gtgactcaat cttcccttat 3634741 aggttcttct attttgatgg agttatacgg aagggatgtt caaggtttct ccacagtaga 3634801 atcggataaa ctatggtata gtgaaggcaa tcatgaaaag ataatgggag tgaagataaa 3634861 tgagtgaaca gcaaatgacg aatgaagcgg caaaaacgct tgacggctgg tatgcgcttc 3634921 atgatttccg cacaatggat tgggcttcct ggaagcttct gtccagtgat gagcgccaat 3634981 ctatcataca tgaattcacc gggttgcttg aaaaatgggg cgtagcccaa aaagaaggaa 3635041 aaggatcgca aactctttac agcatcgtcg gccaaaaagc tgattttatg ctgatgatcc 3635101 ttcgtcctac aatggaagaa ttaaatcaaa ttgagcttga attcaacaaa tcaagacttg 3635161 ctgagttcac cattccggca tactcctacg tatcagtggt agagctgagc aactacttgg 3635221 caagcggtga cggcgatcct tatgaaaatc cgcatgtgcg cgctcgcctt taccctgaac 3635281 tgccggaatc taaatatgta tgcttctatc caatggataa aagaagatct ggcaacgaca 3635341 actggtatat gctttcaatg gaagaacgca gaaacttgat gagaagccac ggtttaatcg 3635401 gccgcagcta tgcgggcaaa gtcaaacaga tcatcaccgg ctctgtcggc tttgacgatt 3635461 acgagtgggg cgttacatta tttagcgatg atgtccttca attcaagaag ctagtgtacg 3635521 aaatgcgttt tgacgaagtc agcgctcgct atggcgaatt tggttcattc tttgtcggca 3635581 atcacctttc gcttgataca cttcctcaat tcttatatgt ataatatccc ctcccgccct 3635641 atccggcggg agtttttcaa ttctccttta tcagaattta aataaaattt gctattttct 3635701 tcgttttttc ttacgatgta gataataatc catttttttc aaaggggtgc agttatttgt 3635761 caaaacgaac cgcatttgtt atgggagcca gtcaagggat cgggaaagca atcgctctga 3635821 aattagcaga ccagcacttt tccctcgtca ttaattcgcg aaatttggat aatattgaat 3635881 ctgtcaaaga agacattttg gccaagcatc ctgaggcgag cgtcattgtc cttgcgggcg 3635941 atatgtctga ccagcatacg agagcgggca tttttcagaa aatcgaatct caatgcggac 3636001 ggcttgatgt tctgattaat aatatcccgg gcggcgcgcc tgacacattt gataactgca 3636061 atatagagga tatgacggcc acgttcactc aaaagaccgt tgcctatatt gacgcaatca 3636121 agcgtgcttc ctcactgatg aaacaaaacg agtttggcag aatcatcaac attgtcggaa 3636181 atctgtggaa agaacccggc gccaacatgt tcacaaacag tatgatgaat gccgctttaa 3636241 ttaacgccag taaaaatatt tccatccagc ttgctcctca caacattact gtcaactgtc 3636301 tgaatcctgg ttttatcgct acagaccgtt atcatcaatt tgtggaaaat gtgatgaaaa 3636361 agaacagcat atccaaacag aaagcagaag aacagattgc ttccgggatt ccgatgaaac 3636421 gggtcggatc agccgaagaa accgcagcgc tcgccgcatt tcttgcctct gaggaagcct 3636481 cctacatcac gggacagcaa atttccgctg acggcggcag catgaaaagc atataaaaac 3636541 atcccgcttt ttagcgggat gtttcttgta atgacccgaa cggcaggttc agcttttgaa 3636601 tccgcgtgac aaattcccgc agatcctcct gcttcgacac cattgagatt ctgacatgcc 3636661 tttttccgtt gcttccaaaa atttcgcccg gtgtgactac gacatgggca tgctccagca 3636721 agtaatcgga aaattggtga gatgtctcaa acgtattcgg aatttcagcc catacgtaaa 3636781 aggttccttt tggcttttcc atcttccagc ccagttcctt ttcacaaagc gccgtaaaaa 3636841 agtcaattcg ttccttataa attcgtttca acgattccgt atgctccgga tctccagaaa 3636901 gcgccgcact cgctgcctgc tgcagcccgc cgaacatgcc gacaaataca tgatcctgaa 3636961 attcattgac ggcctgaatg attttttcgt tcccaaccgc aaacgccatt ctccagccgg 3637021 ccatgttaaa tgtttttgaa aatgaataaa gctctgctcc gacagttttg gcatcctctg 3637081 cctcaagaaa gctggccggt ttttgatcga attcaaacgc cccgtatgca aaatcatgaa 3637141 tcaaatggat gttatgctct ttcgcaaaag cagcagcttt tgcataaaaa gccgcatcag 3637201 ccacagctcc agtggggttg ttcggatagt ttaaaaacat aagcttcgct ttttccagca 3637261 cggctggatc aatcttttca aaatccggca gatagccatt ttcttcatac agcggcattt 3637321 cgtaaagctc agctcgcgcc atcgtaatcc ctgataaata ttcaggatag cctggattcg 3637381 ggactaaagc gatgtctccc ggattgagca ggcattgtgt cagcacatac aatccggctt 3637441 tcccgcctcc gaaaagcgcg acttccgttt caggattgat tgtcactccg tattcccttt 3637501 tatagaaagc ggcgatcgct tcctttaaaa aaggatagcc cctgaaaggg ccgtatccat 3637561 gaaacgaagg attcagagaa gcctcccgca aagcctcgac aatatgcggc ggagtgggaa 3637621 ggtcagggtt cccctgtccg agattaatga tatgggctcc cgttttttcc atttccttta 3637681 ccttttgaaa aacgagagaa aactcctgcc ttggaagtgt cttgatgaca tcggacggtg 3637741 ttatttccat ctaaaagact cctttttgct ccgttttgtt atcccgttcc aaaaacgatt 3637801 tgttgacgag cttcgtatgc aaaaacaaac cgcatacgat cacgacaatc agccccataa 3637861 tgaccggagc gcttaggatg ttaatgaaca ttgaaccaat agaaatgcat aatccgatag 3637921 acgcttcggc cactgaaaaa atgcgccctt gaatctggtt tgccgcattt tcctgaacct 3637981 tcacttttgc aagcacttcc ccgtattcca tcgcgatgaa aaagaggatc gccgcgatga 3638041 cagaaacagc gaatatcggt gtgaataaaa acagcgccag cgagacaatg gataaaacgg 3638101 taaagtacgt caggcctcta ttgttgttaa agccccattt gctgacaagc gccgctccga 3638161 taaagccgcc gaagccgatg cagaacgtga gaataaagtt gccgatttcc ccgtcaccca 3638221 gaaagcggct gacaatcgga aaatagctgt acacaactcc ccacagcaaa gccattgtaa 3638281 tcatcgtaaa catggcgttt aatacgaatg aattggtttt gatttccttg agtccttcct 3638341 taaaagactg aaaggcctct ttaatgtttt cagattgaat cggcacaaat tgcagcttga 3638401 tgcggctgat aaaaaatgcc gaaaccaagt atgtcacacc gttaaaggca acagccagct 3638461 ctacagatcc gcctaacaga aagagccctc cggcagccgc cccgacgata atggagatgg 3638521 ttgtcgcttt tgcaaataac gtgttgatgc ttttaatatc tgattccaag gacgacatga 3638581 cagcgagacg ggcgggatta aaaaacacgc cgcttccata agtaataaac agcagggcca 3638641 gaaaaatcag cggatactcg ccttttggaa gaaatgtgag ccccaaaaag atgatgcctc 3638701 tgatgatatc cgtccacagc atgatcttaa ttctgtctaa ccggtcgacc agaacaccca 3638761 aaaacggctg aaacaccatc ggaatgcttc tgaccacgat gaccccggac gtcacccaat 3638821 aatcgtgata atatgtagac aaaatgagca gggcagggag aacacaatag tctcccatga 3638881 acgatagcgc ctgcccgtaa agcaagtatt tagagttggg tttcagctgt ttcatactgg 3638941 cagcacatac tttgccgtca gcttcgcatg ctgctgaatt tgtctgattg attcagccac 3639001 atcctgtgaa ttactgcctt tcagttcaaa tgcagcaatg gaattgaaag cttcaaacaa 3639061 tgtcaaatca actgaagtgc ctggtgctgc ggccgaaaaa gaaacgattt cagtatcccc 3639121 ttttaaaagc ccgtccggaa tatcgatcgc ttcaatgacc aaatcctcag cagtttcagg 3639181 aatttggcca ttttgtttga aatgctgcgg gtacaaatgg cagtcggcaa cataataagg 3639241 ctcttgatcc aataatccgt ccggcagatc ggcgtctttt ccgaaacaga ggacatctaa 3639301 taataattgc gccatatcaa ggccaaagac ctttttaata ttggggatca tattccagcc 3639361 ggcaaatctg gctgccgact ctattaaacc cggttctctg tttttcatta gcttgatctc 3639421 tgtatgtgtt gcgcaatttt gcagtccaag cccttcattt gcctttttgg cagcttcgac 3639481 aattttcttt tttgcctctt catccagaat ggacggcgta atgtgggatg tctctgtaaa 3639541 cccgatttgc ggcgttttat catgaatggc gatcgggaaa tactcaccgt cagccatgat 3639601 gccttctata ctgatatagt cggagtaccc ttctgtttga taccagtctc cgtactcacc 3639661 ctgtaaaaat tcttcagcga taaacggcgc ttcaaacgta accgcctttg gcacgttaat 3639721 tgatttcaga tagtcattga ctctgttaaa ttcatcttct gccgtctcag tgtccgtaat 3639781 cagcgttaca ccgatagaac tcgctaagta tgtaggcttt aagataagag gtgtgccgat 3639841 ctcttcaaga gcagcacgga aatcttcaag agttgtgact cgtttgtttt tgatcgattt 3639901 gactccggcc ttattaaaag cgtccctcat tttattttta tctctggcat tttcggctgc 3639961 ctgcacgccg gcacctctca agcccagacg ttcacaggct ttcgccatcg gagcaatgaa 3640021 taattcattg tttgttgtga tggcatccgc cccaaacatt tcggcaacct tgacgatttg 3640081 ctcgacgacc tcttcctcag gcttgttatg atcttcatgc gcccaataaa tggaatcagg 3640141 gtgttcaaaa tcagctaaac tcttaaaata gtctttatct tttatgaccg cgaccgagta 3640201 tttttcaatc aatgctgcat gggaggctgt aattgcaaaa ggtcttggaa taaagctgac 3640261 caggttatat ttttcagcag cgcttttata aaacatgtgc ggcgggcagc ctccaagatc 3640321 agcgatgacc aatactgttt ttctctccat atgtaaaaca ctccttctct attgtgcggt 3640381 gtatcctccg tctgcggtga tggcgcttcc ggtcatatag cttgataaat ccgaggctaa 3640441 aaacagcatc acatttgcga tttcttcagg tttcccaagc ctcagcagcg gatttacctt 3640501 cgctttttct tttttaatct cttcaagtgt gccttcatta ttttcaagga atgatttttc 3640561 attcagcggt gtgtcgatga tccccgggca tacgcagttc acccgaattt gatgtttcgc 3640621 ataatcaacg gccattgatt tagtcagctg caaaaccccg cctttgctgg cgttataagc 3640681 aggaatatca ggccatgcca cgagtccgcc gacagagcac gtattaatga tgttgccctt 3640741 gccggcggcc agcatatgct tgagtgcatg tttgctcatt aaaaacatgc cggtcaaatt 3640801 gacttgcagc accttgttcc aatcgctgag ctccatctcg tgaataggcg ccacgatttc 3640861 gatgcctgca ttattaatca agacatcgag cccgccaaat gtatgaaccg ccgattcaac 3640921 tgcgtgctgg caggcagctt cgtctgtgat gtccgtttgc acaaagtgca gcctgtcatt 3640981 attttctttt cgtaccattg cttctccttg cgcttcatca atatccgcca caaccacatt 3641041 ggcctgctgg cccaaaaaag cctgaaccgc agcataacca atgcctgatg cgcctcctgt 3641101 gatgaggacg gttttatcgg tgaggttcat gatcattcat ccgccttcat tttttttgct 3641161 tttgccctgt tatagcgcgg cgggaagaag atattaatcg attttgattc tttttctgaa 3641221 cggttgatgg caccatgatc ttcgcgaggc tcacagaaat aggctgtgcc gaatttcatc 3641281 tcgactgtgc agccttcgac cgtcatgtca tagccgccgc cgatgcagat gcctatttgt 3641341 tcattccgat gtttatggaa aggcatttct ccgccatttc cagggatttt ggcaagcata 3641401 atttctaccc aatcctcaac aaagaacgtg acttccatgc ccggcagcag gtctcttgtt 3641461 ttgaaaatat ccaaaaagta gtcctcagga cttgtatatg tttcatcagc tttcagccgc 3641521 ttgatatcaa tagcaatcac ttcttggtct gtgtcgtttc ttgccccgtg aggcacatgc 3641581 ggcggcgcga tataggcaga ttccaaggct gtcatttttc ttgtcacatc tccgacagtc 3641641 atcatcagct cgccagaaac gaccatgccg atttggacct ccttatgctg atggggttca 3641701 acattggtat gcggcgggac gtaagacatt aatacttcag tatcccctcg tacggttgaa 3641761 tactgcctca ctccgttttc ccattcaatt aatttcggtg tcgggaaata aagctcctgc 3641821 atatcttctt tagttttcat catcaacgtc tccttttcca aataatgacc agctcattgg 3641881 aatgcttttg aatgttttta caaaggttag cccgtacttt tgccgtgcaa gctcattggt 3641941 taaggcaatg tcatacaaac cttcttttac ttttcttgcg gcttgactgg ttgaattgac 3642001 tagtttgaaa cgaacatctt tgcgggtaaa atattttatt aaattaatag gtgaaggatg 3642061 tgaaacaata acagatgtat caagcatatc gtctctgaat tcaaaatcag gacgaacagc 3642121 caggccgtac atcggtgtat cgcacctgaa gatctgcaat agctgcaaat ccggcctcat 3642181 gtagaaatgc ttaatgccat cgtaagcatg tgggacgatg gtatattcca gcgggctttg 3642241 gagcgtcctt tcgatgcacg attcaaaagt atcatgcaag gacaatttac tgttcagccc 3642301 ttgtagaaga gtaaaattgg aaatgaaatg ctttgctgcg tactcactgc ttgtcccctc 3642361 agggccgagc gtgttgactg taatgagttt ggatagtgaa tcagttcttt tttttgtctg 3642421 aatgctatta tccaatataa tcatgagcac caaccaatct tttaaaattt taagtaaatt 3642481 ttatccagtg gaaattgaac tgtcaatgtt ttttgaaaat attgataatt attcccatac 3642541 aaacaaaaaa accctttaaa aagggttttt aattatagga atttagaaac tttgtttatt 3642601 gagataagga ctgatcggcc ttctgctcaa gtttgccgta ctttttatat gcgaatacac 3642661 tgagcacaaa tccgaggact gtgatggcgg cgcaaatcaa tccgacagct gcatagccgt 3642721 atgccacata tacgggtccc attaaagcag aacctaatgt cacggccaga ttcgaggcga 3642781 gactgtaaaa caccatgact tttcctcgat gacgctctga gcagtcactc aaaatggtgc 3642841 tgagcagcgt caccgtcaaa ctttgcatta atccccaaat aaataggctg gcgattaaca 3642901 gaaacataga cgccggcgca tatggtaaac acgccagcag aacgctgatg acccccagcg 3642961 caatcaaaag ggagcgcatt tttccgatgc ggtcggctat ctttcctgta atcacactca 3643021 tggaaaaccc gattccataa atcatgataa ataagcccgc agccgtgttt cctccggtaa 3643081 aaacgtcctg aagataggtg cctaaaaagg aatacatacc gtaaaaacca atcatattac 3643141 aaaaggttat tgtgatataa acaggtacac gagggacttt cagcgcatcc cggaatgttc 3643201 ctgcgggctc ttctatttct tccttgccgc tgtttttatg ttgggcatgg cggcgcattt 3643261 caaggagaat cagcagaaca actaaaacac ccatcagggc gaaaatccaa aacgtccatc 3643321 tccaatgcag gacgccgccg ataaatgatc cgagcggcac tccgaaaatc agcgccagcg 3643381 accagcttga aacgatcagt cccatcacct tgccccggta tgtataagga acacgatcac 3643441 cgacaactgc gtaagcggtc ggaacaaacg ctcccgcagc caatcccgaa agcgcccggc 3643501 ctaaaaagaa gaaaaaaata ttttgagcta aagcgcatat caccgttcct atgataaaaa 3643561 tcataagccc ggccaataag ctcagttctc tggagtattt atcgcctaat ggaaccaaaa 3643621 gcggcgcacc gataaaaatc ataacgccgt aaatactgat agataacgca aggacgctga 3643681 catctgagct gaaggctttt gctaaatccg gcagcagcgg tgagatcaca agctcttcag 3643741 atccggctgc aaataccccc atcgttaaag ccagtgccaa caataacgga aaatgatgtt 3643801 ttgttttgat gtcattgttt tgattgctgt tcattctttc tcaaacacct cttccataat 3643861 cttcttatca taaagttgta ttatagttta gcattgtttt ttctctattt acaattcgaa 3643921 cgaaatattt ataagtttta ttattttcat ttaaatccca ttatatattt ctatatttca 3643981 ttctaaaaat acatgaggat gtaacacgta aaaaaagctc tccggcctcc cggagagctt 3644041 tttctattgc gcctctgtct gctttttttc aatcgtttca tgatttatac gctttttgat 3644101 gcttagatga tagtatgcat aacagaaaat aatgatcggc acaccgcagt ataagccaat 3644161 tctttgatcc ggaatgaaaa taaggctgat caacacgcag ccatataaac aaaatccgag 3644221 aatcgggact agcggataaa gcggcgttct gaactccaga tcattcacat ttccgccttc 3644281 tgccaggaaa cgcctgcgaa agaaaaattg cgacgcacaa atggacatcc acgcgacaac 3644341 tgtcaccatg cccgagattg agatacacca taaatacact gtttctgcag ccatgacact 3644401 tgtcagcagc gaacagcctg aaatgcctag cgtaatcagc agggcattca tcggcacgcc 3644461 tttttttgtc agtctggtga gaaaggaggg acccatttga tttgatgaaa gtgaccacat 3644521 catacgcgac gccgcataca atcccgaatt agcaacagat aaaatggccg ttaagatgac 3644581 aaagttcatg atatctgccg aaaatgggat gccgatttga tcgagtactg ctacaaacgg 3644641 gctttcaatc acccccgccg ttttgtacgg aaggatggca accaagacga acatagcgag 3644701 cacaaagaaa aacagcgtgc gccaaataac atttcgaatg gactttggca gtgttttttc 3644761 cgggctttca ctttcccctg ccgcaatgcc gacaagctcc gttccctgga acgagaagtt 3644821 taccatgacc agcgtaaaca taacggccag caccccatta gggaaaagcc ctctatcagt 3644881 cataaagtta gacaaaaagg gtgtctcctg tccgccttta aagtcaatca agccaaacac 3644941 agcggctccg ccaatcacaa taaataatat gatcgccgcc actttgatgc ttgaaaacca 3645001 aaattccatt tccgcaaagc ttctgacaga gagcgcatta atcaaaaaga tgacgatgcc 3645061 gaacacgagg caccatatcc agatcggaac ggagggcagc cacctttgca tcaaaatgcc 3645121 tgctgacgtc agctctaacc ctactgtatt ggcccagctg aaccaataca gccagccaat 3645181 cataaagcct gtcgactgtc ccagaaattt agtggcgtag gcctgaaacg atccggccac 3645241 cggcatggca acagccaatt ctcctaaaca aagcatgacg agatacatta aaaatccgcc 3645301 gatgatatac gcggcaatgg cgccgagcgg tcccgcctgg ctaatggtaa agccagagcc 3645361 tagaaacagc ccagtgccaa tcacccctcc caaagcaatc ataaacaaat gcctgctttt 3645421 catgctgcgc tgcaattcat ttttatgatt ctgcatcatc cttccccctt tggttctttt 3645481 gccgtgatgg tcatccggta gctttgcaaa agatgaacgg tggtttgctg tatgaggaga 3645541 ggcaatacat gaaatgtgta cggtttatag actcgttctg tccatttatg gccgtctttt 3645601 ccgtacacgc ccatattaat ggatggaata ttcagcttgc gtatgtcttt gaacggaatg 3645661 gtcccaatca tattccaccc agggaagttc ctgataaaag aatcaatttc gccatcggtt 3645721 tcgtgcagtg ataaaaaact gccgtctgcc aagtagggga aaaacttttt gaagacaaat 3645781 gtttcgcctg tcgattcagc ggttttgtca gccgcttctt taatcacatg ctgcaaaagc 3645841 tgatctcttg cgctatcttc tttcaaatag ttatgcggca ggtaaggagg tgcgtaaaat 3645901 agaatgactt ttgcgccttg atcggggtca agcttttgaa gctcttcgat tgcctgaaag 3645961 catctcatgc gaagttcaag gtgctcgttg gctttgaatg tctgctcgat acactgctcg 3646021 ggatctattc cccggtttct cagcttttct aagtattgct ccaggctata cacttgaatg 3646081 ccccatgata aatgtttctt tggcaggttg gctcttttta catattcttc gtaataatct 3646141 gataattttt gttctgtctc ccggcatgct tcctcagtga cttcaataag caaatccatc 3646201 atttcttttg ctgttctttc ataaataaaa caattgaaat acaagctggt gctgacagcc 3646261 gtttgcacat tataggattc cttgttatca cgctgataca aacaggatgg gggcagaacc 3646321 aactcccctt caaccttttc tgccagatgg atgttattgt ggagacggct tgtgatttca 3646381 gatgaaatga aatttgggtc aatccctgcc agtgtatcgc caacatggac ttcacgcccg 3646441 taaatgtaaa agcaaggcaa cagttttccc gcggctccgg tatagatata tcttgtctga 3646501 tcaccatcgt aaagcggggt aataaaatcc gtattaatag cagccaaata gtgaagctgt 3646561 ttttcttttt ttagccggtt cagctctgaa atgctggcga gaatgcccga atgctggctc 3646621 tcctcatcgg gattggccat aaacaataca tttcccggca acgtctcaag gttctccgaa 3646681 aaatgcagga gattggctaa atgcacggcg atgccgcttt gcatatcgac agatcctctt 3646741 ccgaacatcc actcgcctga tttggcatcc cgctgaacat cctgatcgaa ctcatagcgg 3646801 ctgaaatact cggccaattt ctcacaatca aaagcgatat cctttaaagg gccgaaatct 3646861 tcaattccaa ctgtatccag atgggcatgg taaatgactg tatttcggct ttctccatgt 3646921 cctttaataa acgcaaaaat atttttgcgt ttgtatgggt cattgggaat ggcctgttcc 3646981 cacacatgac tggggttttc ctgaaaataa ggatagctcg tgatcacttc tttgatgaaa 3647041 tctgcttttg tcccttctcc aacggtgccg ttcacgctgc tgaggctgac cagagatgct 3647101 gtcagcgcct ccactctttc agccggattc atgtgactga tttttgtata ctgcataaat 3647161 tgtcctcctg atcaaaaagt tgaaatcgtg cgatccgcta aagaatcgca cgattttatt 3647221 tctctcaaat caaaaagctt cggacgttgt tttggcttgc atatgaagaa ttaagtaatc 3647281 gggaccgcct gcttttgagt ctgttcctga catattaaaa ccgccgaacg gctgatagcc 3647341 gacaattgct ccggtacatc ctctgttaaa atataggttt ccgacatgga aatcctcgcg 3647401 cgcccgttca atgtgcgcac ggtttttcgt cagaagcgca cctgttaatc cgtattccgt 3647461 gttattggca atctccagca tatgatcgaa atcacgcgct ttgcaaatcg caacaaccgg 3647521 gccgaaaatt tcttcctgca tcaagcgggc gttttcatca acatctgcaa agatcgtcgg 3647581 ctgaataaag tagccttttg aatcatcgcc ttctccgccg gccaatagct tgccttcaga 3647641 tttgccgatt tcaatgtatt tcatcacttt gttgtaggat gcttcatgaa tcacgggacc 3647701 catatacgta tcaggatctt ctggattgcc gacagtcagc gttttggtca gcgccacagc 3647761 tttttccacc acttcatcat acacatcctg atgaatgacc gcgcgggagc ccgcagaaca 3647821 cttctgtcct gaatatccaa atgctgaata cacgatagag gatgcagcaa ggtcaagatc 3647881 agcgtccttg tcgacaagca ctgtgtcttt tccgcccatt tctgcaatta cccgtttgag 3647941 ccatttttgg cccggctgca ctttggcagc tcgctcataa atccggcagc cgactgcacg 3648001 ggaacctgta aatgagacaa accgtgtctt cggatgctca actaagaaat caccgatctc 3648061 cgcaccatct cccggaatgt aattcagaac gccgtttggc agacccgctt cctccatgac 3648121 ctcgacaaat tttgctgcca ctaccggggc tgcgtcagcc ggttttaaga gaatcgtatt 3648181 tcctgtcaca atcgctgcca ccgctgttcc cgccataatc gcgagcggga agttaaatgg 3648241 agaaatgacg atgccgacgc caagcgcttc gtaatgatat tgattgacct cgccagcacg 3648301 gctcttcacc ggagcccctt ccttgagctt taacatttgg cgcgcgtaga actctaaaaa 3648361 gtctatcgct tcagccgtgt ccgcatctgc ttccttccac ggttttcctg cttccttcac 3648421 aagatagctt gaaaattcat gctttcttct gcgcaaaata gccgctgcct taaagagaat 3648481 atttgcgcgg tgctccggtc tttgtttttt ccaggaatca aatgcctgca atgcggcttg 3648541 catcgctttt tcagcaagct cttgatccgc tgtagacgcg tacccaatga tctcttcttt 3648601 atttgccggg ttaatagaaa tgattttgcg gtccgtttca attttttctc catttatgac 3648661 aagcggataa tgcttgccga gctgagtgtt tacaaaggcc aatgactccc caaatgcagt 3648721 tttattcttt gcttccgtaa aatcggtaaa tggttcgtgc gcgtatgtga ctgtcatatg 3648781 tagtccccct cgtgttatga aatatatctt cgcatatgaa taaaaatgca agaatcatgc 3648841 cattttcttg tcttttgctg aaaaaacttg ttgaatcgaa cagaaatttg tctaacaggt 3648901 gatcaccttt ctctttttcc gatcttgaac gcaaatttat tttgcgtttt ttgctcttta 3648961 cgcaaaaaac aaatgcaaaa ttattttgcg gaggcttctc aaattagacc catccgcgga 3649021 aacgcgatgc ttctgccgat tttctgatgc ccgtcatgta agccgccaaa cgcatatcca 3649081 ctttatgtgt tgccgctgtt tgataaattg tttcgaacga gctgaccatg acgcttctca 3649141 gtttttctgc aacctcttct tccgaccaat aatatccttg gttgttttgc acccattcaa 3649201 aataagaaac cgtgacgccg ccggcactcg ctaggatatc cggcacaagc agcacgcctc 3649261 tttcattcag gatcttagtg gcatcaatgg ttgtcgggcc gttcgccgct tcaacgacga 3649321 ttgacgcctg aatgttatgt gcgtttttgg ctgtgatttg attggagatc gcggcaggca 3649381 ctaaaatatc gcaatccttt tcaagcagct cctcatttgt gatgacgtca gtaaataaat 3649441 tggtgaccat accaaagctg tcccgtttat cgagcaaata agggatatca aggccgtctg 3649501 ggttgtagag cccgccattg gcatcagaaa tcccgatcac cttcgcgccc gcatcgtgca 3649561 tgaatttggc caggaagcta cccgcgtttc caaagccctg tatgatgatg cgcgcgtttt 3649621 gcagcttgat cccttttttc ttcaccgcct cttcaataca aatcgtgacg ccctgtgccg 3649681 tcgctgtttc ccgtccttgc gatcctccca aaacaagcgg tttacctgta ataaagcccg 3649741 gagaatcgaa ttcccgcagc cggctgtact catccatcat ccacgccata atctgcgaat 3649801 tggtgtacac atcgggagct ggaatatcct ttgtcggacc gacgatctgg ctgatggcac 3649861 ggacataccc cctgctcagc ctttccagtt ctccaaatga cattgtccgc ggatcacaaa 3649921 taataccgcc cttcccgccg ccgtaaggaa gattggcaat cccgcatttg agcgtcatcc 3649981 aaatggataa tgcctttact tcctcttcat taacttctgg atggaagcga acgcccccct 3650041 ttgtcggacc gacagcatca ttgtgctgtg accggtagcc tgtgaacact ttgacgctcc 3650101 cattgtccat tttgaccgga atgcggacag tgagcattct ctgcggctct ttcatgagtt 3650161 catacatatc tcccggataa cccagcttcc gaagggcttc cttaatgatt gtttgggtag 3650221 acagaaataa gttaagagct tctttttctt catctttcga gacttgcttt gctgacatct 3650281 ttttcacctc attgtttttt tggccggctg taatgtaagc gctttaaaaa atcagcccgc 3650341 caattccttt cttcattgga ttcaccctta tcatcatgca agatccgtac cagcttttga 3650401 atccacaaaa aaagagactg aaaacatctc agtctctgac tacaaatcta tcgattaacg 3650461 gggatcaatc accagctgcg tttcagcata aaaactgccg attcccaaac cgtttactac 3650521 atcgccttta atcgtgtaag tgcctgcgcg aggaagagtt ttacgcacca tgacaaggtc 3650581 aaattcggat gcgcctaaca aatcaagcgt aagcgggagt ctgactgttt ttccatcgtt 3650641 taaaatctgt gtttctttca gtgttcttcc attcactgaa tctcttgtcg tagcatgaaa 3650701 cccgtcagga aattgaaatt ctaccgctcc aagagaaagc accgcatttg gtttatatgt 3650761 cacttcaata tcagaaatgg tccactcttt cgtgctgtta actgtttttg cctcgattga 3650821 tgcagactgt gcatgagctt ggcccgaagg aagtaagatt gatagtaaaa cagctgaact 3650881 gatgaataat gaagatacga atgaagttct ttttagcatg acatttcccc ctaattgatt 3650941 gttgaaattt ggccagagcg tcctctgcag aaaaagcgct ttttcataat tcgcgaatta 3651001 ccagttcttt ttcttaaaaa ttaatctatc atcattttcc atggaagtaa atgtttttta 3651061 aggaatatta acacttggaa ttcaatgaga attccttcct gtttatacaa ggttcaaatg 3651121 gacgatttcc ctctcttttt ctagtaacat ctgcctgaca ttttatatct tttatcctat 3651181 tttaaaaaag ggcaaaaaaa gtcgaagatg cctctgctct tcgattgatc acgttcctat 3651241 ttttatctga attcagtgtt ccagttaaaa ccgatcgtct catcatccca cggaattctt 3651301 ttttcatcag gctgatccgg gttatacgac atggtggtaa aatagataat tgtcagcggc 3651361 gtctctccca gcactctata tccgtgagcc accccttttg ggattaataa cagcatcggg 3651421 ttgtcttcgc ccatataata gacgtccgtt tctccttttg tctttgaatc ctctcgaaga 3651481 tcgtatagga caacctgagc gtggccggtt gggaagaacc agagatcatc ctgcttctca 3651541 tgataatgaa atgccttaat cacacccgga tagcttttcg accaagaggc ctgcccaaaa 3651601 tgctcaagga gattctcatc gtcccggacc agctcagcaa aaaagcctct gtcatcgcta 3651661 tgcttcatca attttttcac cttgactcca tcaatcacac gcactgctcc tttcctgcaa 3651721 atactctcgt aacgcttccc gccagtggcg ggggcggatg ccggcttctt caatagcccg 3651781 atggctcagc acagagtatg ccggacgggg cgttttgttc ccgtattcct ctgtcgttac 3651841 agacaaaatg gctgtttcca gcccgctttc ttccataatt gccgtcgcaa actcatacca 3651901 gctgcatatg cctgaattgc tgacatgata gatgcccggc ggatggctga acagcttgat 3651961 gaccgcttct gctaaatcct tcgtataagt cggcgaacca atttgatcgc tgacaacccg 3652021 aagctcttgt ttcgtttcag caagtttcag catggtttca acgaaattac tgccgccatg 3652081 tccgtacacc cacgatgtcc tgatgatcgt gctgtctttt gtcgttaatc gtatcagttc 3652141 ttctccgagc cttttgcttt tgccataaat ggttttcgga tcgaggggat cgtcttccct 3652201 atatggctgg gttcctttcc cattgaatac atagtccgtg ctgatatgaa catattgagc 3652261 tccgatgcgg gttgactcaa gcgctgtata ataagcgccg attccgttaa tcaagtacgc 3652321 tttatcaagc tctttctcgc attgatcaac cgacgtaaac gcggcgctat tgaccacgat 3652381 atccggctga taatggccaa acgaatgccg tactgagcgc tggtcagcaa tgttcatcat 3652441 cttctttgtt aacgcaatga cctcatatcc ggcttgcttc agctggcggc atagttccaa 3652501 gccaagctgt cctcccgccc cagtcaccaa tacctttgtc aatcagatca ccttctcatc 3652561 ggtcattgtc tgtataccac tgaatcgtac gcgcaatgcc ttcttcaaac gtcacttcct 3652621 gccgccagcc cagttcgttt ttcagctttg atgcattgat cgcatagcgc cggtcatgcc 3652681 cttttcggtc ttccacgtgg gcgaacaatt cctcacagcc cagatgcttc aaaatgacac 3652741 tcgccagctc tttattcgtg cgttcatttc cgccgccgat gttatacacc tcgccgtcgg 3652801 tccctttttc taaaatcagc ttgatcgcgc ggcaatgatc ctccgcaaac agccagtctc 3652861 ggatctggag tccatcgcca tacagcggaa caggcaggcc ctgcttcgca tgacggataa 3652921 tcgtcggaat cattttttcg ctgtgctgat aaggtccgta attgttgctg catcgtgtaa 3652981 tgatggccgg aagcttgtgg gttttcacat aagacaacac gagcaaatca gagcttgctt 3653041 tgctggctga gtatgggtta ttaggagaaa gcggcgtcgt ttctgtaaac gcgggatcat 3653101 ccgcttttaa atccccgtat acctcatctg ttgaaatatg aatcagcttc ttggcttttc 3653161 ctttcaagac cgcttccgcc aatcggtatg tccccatgac atttgtggtg ataaacggct 3653221 ccgcttggga aatgcttctg tccacatgcg attctgctgc gaagtgaatg acgccatcgt 3653281 aggtctcgtc aaaagcgcgg tcgatatcct cctgaacgct gatgtcccct tttacaaagc 3653341 gaaaacggct gttttgcttt aatttttcca tttcctccgg gtggctggcg tacgtcagtt 3653401 tatctaaaac ggtaatgcgc gcatccgttt ccctcagcat gagctttgta aacgtgagcc 3653461 cgatgaagcc ggccccgcct gtaattaaat atgattttgc catcactttt cgtcctgtcc 3653521 tttccgtaaa gcctggtgta caagctggga agcgagataa agcgattcgt gagttccggc 3653581 atctacccac cagcctgata acacatcata cgtaagctgg ctgttttcga tgtatagatt 3653641 attcacatcg gtgatttcca gctcgccgcg ctttgatggt gatatttgtt caatatatga 3653701 aaacacctct gcatcataca tataaatgcc ggtaacacaa aggttggtcg gtggctgttc 3653761 gggcttttcg atgatggaac gaatccgctt gtttttctca tcaatctcag caatcccgaa 3653821 acgttccggg tcatcaactt ctttcagaag cacttttgct cctttcccct gctgttcaaa 3653881 gcgttctgta taaggcttta atgaatcttc aaatatatta tcacctaata ataaaatgaa 3653941 agactctttt ttcgtaaagc gctttgcata agacagccca tccgaaatgc ccgatgctgc 3654001 cggctgtact tgataagtga tagtaacgcc aagctcttcc ccgttcccaa gcagtttgta 3654061 aaattgcggc atatgctcct tttggctgat gagtaaaatg tcttttattc cggcttcctg 3654121 cagcttcata atcgaccagt atatcatcgg atacgggcct acaggaagca aatgcttgtt 3654181 gacggctttc gttaagggca taaggcgtga gccgtttcct ccggctaaaa taacaccttt 3654241 cacattaaca cttccttaca tgcattttta tatctcttgt tcatataaat cttgaagaat 3654301 agctgttacc cgtataatgc ctttgccatc cacgagcggc cttcctccct tgtgcaaaga 3654361 aaggcgaaga ggatagctgc tcataatgcg tgacatctga tagatgagtg tttcatccgg 3654421 tacaagctca cccaatccaa gatcaagagc ggcgccttgg tcagcaaatg ttttggctgt 3654481 agccgtttga tgctcaacct gagaaagaac aaggcacggc acgccgatgc aaatggcttc 3654541 atatagagag atgccgccag cgacaatggc tgcgtccgct tgtttcatca aacctgccat 3654601 atcatttgtc tgttcgatca tcttgtactg cggcttcttt tcgatccgcc ttcggactgc 3654661 ctcttgatgc ggtgaagcgc tccccatcac aaacatcatg tttttgtctt ttatgtcggg 3654721 gacttgatca gcggcagcca gcactttaaa aataagctgc ttcggatcac ttcctcctaa 3654781 tgcaacaagg atattgcggc agtctttctt aagtgtgtaa tcctctcttg cggcctgaaa 3654841 ggcggggtga agaataagat agtccggacc ttcatagatg cgtgtgtttc cctgaacgta 3654901 caccctgctt ctgatgtcac cgtaaattcc gttaatgact gcgtcactat attgaatcga 3654961 tttaccgttt ttctcttcaa aaagaacaat tttcgcatct gtctccgtct ttattttctt 3655021 taacagctct gcaggcgcgc ctagaatatc aaacaaaagc aaatcaagct tcttgctttt 3655081 tatttcccgg agaataaatt cgtgctgctg cagctccggc tttacgatga cctgccaatg 3655141 ctcttcatga agaaacgctt cagaatcctg attcgtataa aacgtaatca agcatcgctg 3655201 tttgagcccc tccgcaagcc tcttcatccg gacaacatgg cccattccct tttcatagcc 3655261 gccgtctgcg aagatcccaa catgcatggc tagtcagcct ctcgttcggt tgccgcatcg 3655321 gggttccggt tcagaagggt gataagctct gaggcggata catcggggcg ctcgcctgct 3655381 ttttgataga gggcctttat cgattcatag tcttcctttg tatcaatggt cagccgatat 3655441 tgaggggcgc gaaatcgttc cggcgcctct aaaaactgaa cacgataaag agctggatga 3655501 ttccttatat ataacgtgac atgctcctga tattgatcct ccaaagcctg aatacggctg 3655561 atgtcaatta acaggttggc gttgaccact tcgccgcaaa tccctaatgg ggcattcagg 3655621 atatacgtat aatccgagcc ttgatcaaaa tgcgcctgaa tcattacatc gagcagctca 3655681 ggatcgacaa acggattatc acctgttaac cggatgatga ctgacggttt aacagcttct 3655741 atgaccttca caaacctatc gaggacacgt tcttcgctcc cgcggaaaac acgaaagcct 3655801 tgtttgatac agtgcgcctc taatatgtcg tcagtttctt tgtcagacgt ggcgatgaca 3655861 agattatccc gatccttttg gtaaaacgcg ctttgccgga cacggtgaac gagaatatca 3655921 agtaaacgat tcgatccgag cggccgaagc acttttcccg gaagccttgt tgaacccatt 3655981 cttgcttgaa tgataaagag aatatcattc atgaaacggg ctgtccttca gtaaaatgtc 3656041 atcccagaca atgcctgtgt cggctggaat gtctcttaca gcccgaacac cgctggtcag 3656101 cagttcaaaa aatctcgggt gcagcccctg cggcttttgt ccgggccgaa gcactgcgat 3656161 attgtcttca ctaaaggctt cacctttttg aatcggagct gttgtaaaaa tgcctctgta 3656221 tgcaaagttt ctgatttctc cttcgatggc ggtcgttgtt ttgtatgaac tgccaagcag 3656281 tttttcagag accggctttg tgatcccctg tttcagctca gcttccgttt tcctgatgcc 3656341 atcgaccatt tctttcaatt catccggatt taatgcaaac gagtggtcag cacccggcag 3656401 atttttatcg atcgtaaaat gcttttctat cagttttgct ccgagccgaa ccgcggcaca 3656461 cggcgcttct gtcggatgct cgctatgatc ggagaagccg attaccgcct caggaaaagc 3656521 ggcggcaagc atcggaatga cgctgaggtt gctgtactcc ggcggtgctg ggtatttcgc 3656581 cacacaatgc attatggcaa tttgattgtt tccctctgcc ctgatggtgc gccaagcttc 3656641 gtgaacatca gagatttcag ctccggctgt cgagaaaatc atcggcctgt tcagccgggc 3656701 gacatattta agcagcggga gatggttaat ttcataggat gcgattttaa aagcgctcgg 3656761 cgaggtagac tgaagcagat cagctgaccc ctcgtcacat accgtactta aaaagatcac 3656821 ctgcttttcg cggcagtaat ccaatagcgg taaaatccac tcagcaggca tttccataga 3656881 ttgaaccaaa gaaaaaatag agacgtcctt gcccgctgcc gtcttgtaca aaccaggatc 3656941 tttctggtac atcctatcag cttggaacat ttgaaatttc acggcatccg ctcccgcttc 3657001 cgccgcggcg tctatcagcg caaaagcctg atcaagcttc ccgtcatgat taatccccgc 3657061 ctcagcaata ataaaaacag gagcgtcttt gcctacagtt ttattcgcga tctgaaacgc 3657121 tgccattatt tcgcctcctt gcccggccaa atatgataat agtaatacga ttgttcagcg 3657181 gtgaagccca ttcgttcata aaggcggatc gcccttacat tgtgaagctg cgtccccgct 3657241 gttaccgttc tatgcttctg ggtctccggt tgttctatga gattcgccaa taaatgaaac 3657301 gcaatacgtt tcccttcaaa tcccggcttt acagccatca aatcgagaat gcactcatca 3657361 tctcttgata agccctgaag atagccgatg acctcgccat tgtgtttagc gacaatattg 3657421 accgccgccc ttccattcag attgtttcgt gtccactcct gaaatatttc gtttgctgca 3657481 tcgcggctga gatgaggatc ctgaaaatat ctgctttttg taaacgagtc tcgggccagc 3657541 tcacatatcg cttctgtgtc tccgggctca ggcgggccca gttcaaaaaa tggcggtgtt 3657601 ttgtcataaa aagacggagg catcgccagc ttcagcaaac tcccgacaaa gtaagaggat 3657661 ggctgctgtt gtatcacatg cgcggctccg atatcttcag ccggaacacg gacaaagata 3657721 aaatccgttt catccatttg gcgtacagta taaaaagctt caaacagcct ctttagctgc 3657781 ccggtactat ttgccgcaag aagtttgacg ttcatgactt tcttctgaag caccttgctt 3657841 tcccacaaag aatcttcgta aagcaatacg ccttggagcc tgctgttttc aaaaaggccg 3657901 agggaaaatt gatacggaac atccaatgta agctttctgc tttggagaaa ttcctcaatt 3657961 gcctctttgg agacattttc ttttaccgta tacacttaat cagccccttt tacgatatcc 3658021 cgcacagctt caatgacatc atctacatca tcgtcagaca ttgatggata gagcgggaga 3658081 gaaagggttc gtttatagta attcatggca ttcggaaagt ccgcttcctt atatccaaat 3658141 tgcttttgat aatacggatg aatgtgtact ggaataaaat gaacgctagt gccgatattg 3658201 tattcatcct ttaaagccgt aatcatttcg ctgcgcgtaa ccccggcctt tttttcatca 3658261 acttgcagaa catatagatg ccaggcgtgc ctgccgtcat catggacaaa cggcgtgatc 3658321 agcccaggaa tctgctgaaa agcggtttga tagcggccgg caatctcttc tctccgtttc 3658381 tgcatatcat ccagccgttt cagctgatga agtccgaggg ccgcctgcaa atcaaacata 3658441 ttcatcttat agccgggcga ttcgacttca tagtaccagc tgccatttga agaataacgg 3658501 ttccatgcgg ctttactcat gccgtgaagg cttagcaccc gtatcttatc ggcaagctcc 3658561 tcatcatcag tcgtcagcat gccgccttcc cctgtcgcga ggtttttggt ggcgtaaaag 3658621 ctgaatgccg ttgcatcccc gatagaaccg atcattcttt gcttataagt cgtatatacc 3658681 gcatgtgccg catcctccag cacgaataaa ccatgatttt gggcaacagc caatattgca 3658741 tccatatcgc aggactgccc gccaaagtgg acgggcacaa ctgctttcgt tcgcggtgtg 3658801 acggccgcct caagctttac cgggtcaata ttgagcgtgt tttcgtcaat atccgcaaac 3658861 acaggcgtcg ctcccgtatg aataatcgta ttggcggtcg agctgaacgt aagcggagag 3658921 gtaatgacct cgtccccggg cccaatccct tttgctttca aagccaaaaa taaagctgcg 3658981 gtacatgaat tcaccgccac ggcgtgcttc gccccgacaa acgcggcaaa ctctttttca 3659041 aactgctgaa ccttcgggcc tttagagagc catcccgatt caagcgtttc tgtaacctcc 3659101 tgaatttctt ccttaccgat taacggcaat gagtaaggga gaaaatgatt tctcttttgc 3659161 accatttctt tgcgctccta tcattttatt cagtatcttc ccgcctgtaa tcaacccctg 3659221 ttttggcttt cagttccgca aataaagcat ttgttgattc tgccaccgga taattagccg 3659281 ctatgaatgc caggcgcgcc tcttctgctt tttgatgcac gtcgggactt cgaagaacct 3659341 caaccaaggt gtgcgccagt tcatccggct ggtcaaacat aaaatcgcca agagactcat 3659401 aatacggata cgagcgattt ccggacgatt ttcctatcag cacaggcttt tgaaacagca 3659461 tggcttcaag accgactgtc gaggtttgcg tcactgcggc atcaacatac ggcagcaaat 3659521 cataaagctc cagctccttt ttgatgactc tgcatgcttg atgttttttc gccgcctcgt 3659581 gatacagatc aagcttgttt tttccgattt cccacgggtg gggtttgata atgatttgca 3659641 gctgcttctg atcagaaagc ccctgcagca caccggaata aaagtcttct gaaaagggct 3659701 gagtggcaat gagcacaatt tttttagtcg gctgaaaagc aagttttcga tagaatatgg 3659761 acatatccat aggcgttctg ttaaaaatct gatcgaagcg gggatgtccc gttacgagaa 3659821 tctgctcggg tttacagcct tttcgtatga accactctgc ttcatacgca ccaaaaacag 3659881 cttgataggt tgtaaaaaca ggaatgaagg cttcatctcc catcaatgcg ccatgctgaa 3659941 gacaaatgct gacggcccct tttctttgac acatgagagc gagcaccctg ctgtaaatgt 3660001 cttctgccgt tccgacaata acagctgaaa tcttttcctg ttcaaacagc gcatcaactg 3660061 tatcaatggc ctctataaat aaaggaatat ctttgaaaag ccggtcgcga aacgcttgat 3660121 caccaaatgc cgggtgatca tcataagggg cgagaagcga acaggctgtt tcgagatact 3660181 gcttcgaatc gcctttttgg catgaatccg caatctcccg cttgctaatt acaggcagat 3660241 cacaataatg cggcaaactc catctggcca aaacagccgt tttttcagga tcaaattgat 3660301 agtaattttc gtttgaaaaa cgcaggtaat caaagtgcaa aatgactttc cctttaacag 3660361 gttcgtcatt tgttttaacg atgttttgga ttctttcttc aaaaaacggc tgaatctgtc 3660421 cctcatcgat atgctgatcc accgatccga ataattccgg ttcttcttcc atcatcaccc 3660481 tcagttcagg gctgatgtat tgataaaaat tactgataag cccaagcgga atccctttgt 3660541 agcgaagttt gtcaaaaagc tccacgtact tccggtacag cacccaataa ttgcttaaat 3660601 aggccgacaa gctctcaccc cattccaagc ttttttaatg attcacgcag ctctcggcaa 3660661 tttcgctgcg gaggaaggtt cctgacaaat tcattttttt ctaattcaaa cagctgaaag 3660721 tgaatcgatt ggtcggtaat ataattcagg tccagctcct catccagtgg gtaaaacgga 3660781 taaaaatgat tgactctcca aaagaaccgg gcatctccta tacggtaaaa cgccgggctt 3660841 tcatcccaat aggagccaaa cttctccttt accttctcaa gcaccgaata cctgtgcatc 3660901 accgagcaat gatcaattgc gcacggcgcg ttccatgtca cttgagcggc aggcctgaca 3660961 gtttctttta caatgtcacg attctcgttt aaatgatagg ttttggaggc tgagtaaatc 3661021 acagcctttt caggatgggt atcgagctcc cgcaccattt tcaggaggcg gtccggcata 3661081 tagatgttgt catccgtcgc ataggtgata tattcaccct ccgccatctc aatcgcctga 3661141 ttgatcagtg ccgcgtatct cgttttttct gttctttcct tcactccaga tatatcgctt 3661201 tgataaaaac gcactcggtt atcattcaaa aaaggacgga ttacattcag cgtctcttca 3661261 ttggagttgt catccataat aaacaattca aaatctgaaa acgtttgtga gagtatgcta 3661321 gaaatggact ttgccacata atcgcttttg ttatagctcg tcataatgac tgatacttta 3661381 ggcaaatcct acacctcctt cttggaactt cacacctgaa actatcgtta tcttatgttg 3661441 cttatgctca agttgcgcta gggatacaaa ccaatatgcg aaaagtttgt gtatgtttct 3661501 gaaaaacagc ggctgcccag agcgaaatct gatcggtccg ctgttctttt tcagcataat 3661561 ccaagcatca gcctcataag gtgaaagaga taaaaatcgc accagcgact aagatcgttt 3661621 tccatcggag gtgagtcatc gcggagcgtt cacctataca tccagaacat gttttgaatg 3661681 gttttcataa aaaggaggaa cgatatgaaa ccgaaaaaaa atcaatatca gcaaatgcag 3661741 gcatttgata atatgcaggg gtatcagcct cagtttggcg ccaacccgta cccgcagcaa 3661801 ggccaaggct cacaaatgca gacaatgggg atgcagccaa tgatgccaat gcagcaggga 3661861 cagcaaggac aacaaggaca gcagggattt ggattcccgg gccagcagca gggcggcggt 3661921 tttcaaattc catcggggcc tacaccgtca ggaccgggcc aaagcgttcc cggcatgctg 3661981 cctgttgagg aatcttacat cgagaatatt ttgcgcctga atcggggaaa aacggccacc 3662041 atttatatga catttgaaaa cagcaaggaa tggggctcga agatttttcg cggcgtcatc 3662101 gaagctgcgg gccgggatca cattattatc agcgacccga aatcaggaac acgctacctg 3662161 ctcctgacaa tctacctcga ttacattaca tttgatgaag aaattgctta tacgtatcca 3662221 tattccatgg cgtcctattc gccaagataa gaaaaaagcc aatcactcat atgatgagga 3662281 ttggcttttt tgtttataga tatttgacgg ctgcgacaac gatcataatc caagaaataa 3662341 taaacgccac accgccgagc ggggtgatcg ctccaagaat ggagatttgc gtcacactta 3662401 gaatatataa gcttccggaa aacagcacaa ttcccgcaaa catcagccag ccggctgtcg 3662461 tgacactgcc tatgccggat aatttatcag ccagaaacgc gacaacgaat aacccaaggg 3662521 cgtgatacat atgatactgc acgcctgtgt gccaaacctg aagatactta tcaggtattt 3662581 tcccttctaa tccgtgagcg ccgaatgctc cgagtcccac ggcaagcagg gcgttaatgg 3662641 cccctaatat gataaaaact ttcatctatc tctcccgcct tttcgttaaa ctcatatcat 3662701 ttatcttatc gcacctgcac caaaattcaa tgtttgttct ccgttgacac gagattgtcg 3662761 gattttctcc tgcgccaaag ctggaactgg tcagctgcta ttgcagcaag cgtccctaat 3662821 acgagcccgt tgcttaatag agaaataaat accggatgca atccctttaa cgcagtttca 3662881 ggaacaaaca tgataccgac ccctgtcagc agtgagatac cgatgataga cctcaccctt 3662941 tttgattctt ctttctcata tgaatcaaat tcggcaaagg ccagaccgcc cattgcggag 3663001 aacacaacaa aattcaccgc aaatccaacg ggtgacggca ggctcgcaaa cgtattcata 3663061 aaaaacggga tcacgctgat cacgataacc agaatactgc cgagcataaa cggtttttta 3663121 gaaggcatct tggtcgtttc aataaaacct gcggctcccg aaatcggaac aggcgcaata 3663181 gctcccgtca aaccgctaag cagatggctg aatgaagctg caaaaccggc atggcgttca 3663241 tgatgctttc catcaggctg tttgctgaat tttttcatgg cgatgtccac gaccttcatg 3663301 ctcgccagca tattcacgat cagcaagatg gtaataaaaa tagaagtgat gatcaggccg 3663361 ctgttaaata acggggtccc aaaaggaaac agggaaggca gctgaaacag ccggtccggc 3663421 atttcaatcg gctttgcggc tccggcagcc gcaaacagca cccacccgcc gaacaaggct 3663481 aataaaatag aatattgctt aaaaaacatg atgttcgaat ttgtcattat aaaagcggca 3663541 gcgatcacaa caagcgccag gccaaataca agaccgtcca ccccgtcctg tcgataaccg 3663601 attccgagaa ttccttttat aatgggctga ctcagctgca tgacaagaag caataaatag 3663661 acgcccgtta caaccggagt aaacaatttt gcaagtctgt caatgacctt gaaaacactt 3663721 aacaaaaaga aacatacagc gcttacaaga agagctccct gcaaaccccg cagtgtgtct 3663781 ccatatgtcg caaacacagt tcccgtcagc cctgcgtaaa tcgtatacac tccccaccac 3663841 aagccggctg ggctttcatt gatcggcagt ctgtggcctt tcaaacactg aatgacggcg 3663901 gcaattccca gtacaaaaaa agtgctttga atcaatcttg cagaatctga gtgatccaga 3663961 tgaaacgact gggcaaccgc caccggaaca acaatcgccg cagcaataat aaacgctgtc 3664021 cattgcagcg cgccaagaac caatttcacg taagctcaac ctctctcttt aaaaatcaaa 3664081 taaagactct ccgtttccat cctcttcctg cttctctttt tcttgctttc gatatttgtt 3664141 taatcccgcg ctccccatca ttttttccat catcagctgg tctgtcgatg gcggcgcggc 3664201 gggacttggc gtaacgctcg gctgtatgcg gggcgcgctc gcgttctccg gctgatcaag 3664261 cacgacatca cacagagaac ggacaaccgc tacataacgc ttcagctcct catcccgttc 3664321 agccgttttt gcttttttta gctcttcttc catcttttga atcaaagcag atatatgaat 3664381 gttcatgaag caccctccaa aaaaataaat gttgtcttcc tgcattttat caaattcctg 3664441 ctgaaaacgc agatatgagt ttgttatttt ttctgacaaa ccttgcgcga ttgacaagca 3664501 gaagagattt ttcacataat aaatcaccat accttacaaa aaggagaaac ggaatgaaca 3664561 gcatcccctc tatcatcagc aagcataaag cctattttgc ggcgggacat acgagaccgc 3664621 ttgaatcgag actgaacatt ttgcgaaagc tgaaacaagc cgtcagaact catgaagccg 3664681 atctcatagc cgctctctac caggatctcc ataaatccga gcaagaagca tactcaacag 3664741 aaatcggaat cgtcttggag gaaatcagct ttgtcatgaa acggctgaga aaatggtcca 3664801 agccgaaacg agtcaaaacg ccgttgactc atctaggctc caaaagcatc atcatccctg 3664861 agccgtatgg aaccgttttg gtgattgcgc cttggaacta tcccttgcag ctggcgcttt 3664921 ctccgttgat tggcgccatt gcggcgggga acacggtcgt tctcaagcca tcagaatata 3664981 cgccggctgt ttctgctatt ctttccaaac tcatcagcag cgtttttcca actgattatg 3665041 tcgctatggc agaaggcggg cccgatgtca gcacagcatt attacagcag ccctttgact 3665101 acattttctt taccggcagt gtagctgtag gaaaaatcgt catggaggcc gccgccaaac 3665161 aattaattcc cgtaaccttg gagctcggcg gcaaaagtcc ctgcatcgtc cataaagatg 3665221 ctgacattca gcttgccgcc aaacgcatcg tcttcgggaa atttacaaat gcgggacaaa 3665281 cctgcatcgc accggattat ttatttgtcc acgaggacat caaaacgaag ctcacagaag 3665341 aaatgaagcg tgcgatcaga gaattttacg gccctcagcc ggaacggaat ccacagtacg 3665401 gcaaaatcgt cagtgagcgc cactatcagc ggctgctcag ctttctgaat gatggcatcc 3665461 cgctcacagg cggacaatct gatcccaatc atcacaaaat tgcgccgacc attctcgaac 3665521 aagtgagaga tgactctcca gtgatgcagg aggagatttt cgggccgatt cttccgctct 3665581 ttacataccg caatatcggg gaagtcattg agaaagtcca atcgcgccct aagccgctcg 3665641 ccctgtatct cttcaccaca aacaaagaaa ttgagcgcgc tgttttagga aatctgtcgt 3665701 ttggcggggg ctgtgtcaat gatacgttaa tgcatgttgc gacgccgtat ttgccattcg 3665761 gcggcgtcgg ggaaagcggc atcggcagct atcacgggtt tgacagtttt aacacattca 3665821 cgcacaaaaa aagcgtcgtc aaacaaacga accgtttcga cttcgcattt cgttatcctt 3665881 cctccaaaaa cgggctgcga atgattcgaa aaatactcaa ataaaaaagc gcagatcacc 3665941 tgcgcttttt acaaatcctt aatacaccaa tcaatcggcg cctctcccat tttctccaaa 3666001 taggcattcg cccgggaaaa cggtctgctc ccgaaaaatc cgtttctcgc agaaaacggg 3666061 ctgggatgcg tcgattcaat gataaaatgc ttggaggtgt cgatccgttc ttttttcatt 3666121 tgagcatgcc gtccccacaa aataaagata accggccgct ctctttcact cagcacgtca 3666181 ataattcggt ccgtcagtcg ctcccagcct tttcccttat gggaattcgc ctgtccgcgc 3666241 cttactgtca gcacagtatt cagcaaaaga acgccttgct ttgcccagct cacaagcgac 3666301 ccgtgattcg ggatgctgca cccgatgtcc tgctgcagct caagaaagat attttttaac 3666361 gaaggcggct gctttacacc gggcttgaca gagaagctta aaccttgagc ctgtcccggc 3666421 ccgtgatacg gatcttgacc caaaatgacg accttgacat catcatatga tgtataatgc 3666481 agcgcgttga aaatatcccg gctgtccgga taaatcgttt gctccgcgta ttccctcttc 3666541 agcatctctc tgagctcttg ataatacggt ttctcaaact cttcctttag ctgattccac 3666601 cagctgtctt gtaaaagctg tttcaagatt caggcctcct tacgaacgat gaagtctgga 3666661 atagacaggc tcgccatccc aaaccatttc actttttgct tcccgcctct tcatctcagg 3666721 ctcttcaagc aggacggcaa agtttttcgt cggcagctcc ccgagtccgt gcttttcact 3666781 taaacgatcc aaatattgct tccgcttggc gccaaggtca gcagactgat tgtctcccgc 3666841 gtcactgaag gcataaatca cgctggcgca agggacacgc ttcacccggt aatccttggc 3666901 cgcgcgcaaa taaaaatccc agtcccagta attgtgcaca tcagcatcga aatacccgat 3666961 ttcatcatgc agaaaacgtc tgtacatgct gcccgacggc acgtatgtag aaaacactct 3667021 catatcctca tagtcagcgg tataagcaaa caatttccgt gacactggat accttgttcc 3667081 gtttttctct tcaaacgaaa ctatttccgc atcagaatga acgaagtctg ccgtttctat 3667141 ttcctttgcc attttctcga tatgccctgg cgtaaagaaa tcatcgtcat cacacagcat 3667201 aatgcaatcc ccagacgcct cttttacacc ggcatttctc gcagccacat gccccgagtt 3667261 cttttctaaa ttgatgacag caatcggcag ctccggataa agtgctttga ccggcacgac 3667321 cgattccccg gcatcattca caataataat ttcatacggc atcaaggtct ggcgggaaat 3667381 cgactccaaa agctcacaca aagccggaat ccgattatag gtcacaatta cgatagaaat 3667441 cttcatgatg ctctccttct cattttcata gtcatgtact attaaaacat atattggacg 3667501 ggagatcagt gggaatatcc tactgaaacg gcatactaca atgatagaaa cagcaaagtg 3667561 gctccgatca gaagcaccat gatcagcatc agatctccaa agacatgaaa gatatctttc 3667621 atgcggacgc cattcggaag gataagacgc cacagcttag attgatagac cggcagcagc 3667681 accagtgcat aagaaagaca caaaaatgta aaagccggcg gcacaaaagc acagcctgca 3667741 tcgtcccaat tcatcatgat gtctttcata ctagatccat ccaataaaaa caaagatatc 3667801 atgagggcta gcaacacaaa ggaccccaat tgaacctcaa acaggcgcat tttctggtta 3667861 tatgcaaatc ggaccgccca aaaccagaca taagcatatg aacatagcag cgtaagaatg 3667921 gcacctgctg taaagacgac atcaggcagc cgatcaagca gaaaaacaaa aggcaagctg 3667981 gctgccatag ccaagagcat gcagccacca gtaaacaaaa atactgcccc atgagctaca 3668041 aaaccatata aacaagagct aatcctcacg acatacacct cctttacata gaaattctat 3668101 gtatatacct aaaaaatcag acaagctgac gcctgccaat ataacagccc attcggccaa 3668161 ataacggaaa taacagcgtt gcaaaagcac aagttccaac aaaccaaggt gtcaacaagg 3668221 attgaaacag cgcagcagga attacattga atagaaaaac aagcataaaa atgacgtttg 3668281 gcaccattga gatcagaatc gtatgtagaa caagcttttc tccgcgtttt ccaaactcct 3668341 tcacgccttg atacccaatc agcacccagt agatcatata tgcagctaag atcagccaaa 3668401 cagaaacaga aatgcctttc catactgctt gaacaaacgg tgattcaagc catacatgca 3668461 ttattgtaat cgcaatgccg acagcgaata gggcactgtt acagaaaaga tggaacatca 3668521 aaaacgcacg aaacgttact ggctgtattt tcttaaacga agaaacaatg tcagttggtg 3668581 ttccaaacgc ctgcaataaa gtctgcatag cttcctcctc actctttcct tcctgaaaag 3668641 agcgaaacag atgatgttca atatggctct caatctcttc tatcatcgcc tcaccctcag 3668701 gaagcccttt aagcccgctt ttgatttcgg atacatatgt ttctttatcc attttgtccg 3668761 ctccacttca gtattcggtc catcatggct gaaaatacgc tccattcctt cgtgcgttcc 3668821 gccagcactt ctttgccctc gtctgtaatc cggtaatatt tgcggtccgg tcctttctcc 3668881 tgcttctccc agtaggaaga aatataccct tggcgttcaa gcttgtgaag agaaggatac 3668941 aaggtccctt ctttcatctg cagttcattt ccgctgcggc ttcccatttc ttttacaagc 3669001 tcatagccgt acatcggccg ctcgttcaga agcgtcaata ccaatataac cgtgcttccc 3669061 ttaaccagct cacgatttaa catctcaaaa cccctaccta gttttcttat gtagcatttt 3669121 acgaaagccc gttgagattg tcaaatgatt cctatagatc ttctatattg tgatacagag 3669181 aaaatctaac tataatgaaa gacaaaacat gatggaggtt caagacatgt ctatgcataa 3669241 agcactcacc attgccggct cagattccag cggcggtgct gggattcaag ctgatttaaa 3669301 aacatttcaa gaaaaaaacg tatacgggat gaccgcctta acggtgatcg ttgcgatgga 3669361 cccaaacaac agctggaacc atcaggtatt cccgatcgat actgatacaa tccgcgccca 3669421 gcttgcaaca attacggacg gcatcggcgt ggacgccatg aaaacaggaa tgctgccaac 3669481 cgttgacatt atcgagcttg cggcaaaaac gatcaaagaa aaacaattaa aaaatgtggt 3669541 aattgacccg gttatggttt gcaaaggtgc taatgaagtc ctttatccgg agcacgccca 3669601 agccctgcgt gagcaattgg ctccgctagc cactgtcatt acgccaaact tgtttgaagc 3669661 cagccagctc agcggcatgg atgaactaaa aacagttgac gatatgatcg aagccgcgaa 3669721 aaaaattcac gcactcggcg ctcaatatgt cgtcattaca ggcggaggca aactcaaaca 3669781 cgagaaagcc gttgatgttc tctatgacgg agaaacagcg gaagtccttg aaagcgaaat 3669841 gatcgatacg ccttatacac atggcgcagg ctgtacattc tcagcagccg tgacagcgga 3669901 gcttgccaaa ggtgcggaag tcaaagaagc catttacgca gcgaaagaat tcatcacagc 3669961 ggccattaaa gaatccttcc cgctaaacca gtatgttggt cctacgaagc attctgcact 3670021 gcgcctgaat caacaatcat aaaaaaaggg gctgccttac agagaggcag ccctttttaa 3670081 atcaccgaag acttttcaca gaaaaaactg ccgatcccat cggcagcctg tttatttgat 3670141 ttttaaattg tttgcagatt tcctcaaaaa tgtttctatc gactgaacaa aaagtgcata 3670201 ttccttcatt tgttcatatg cccgcgtgag aatttccgcc gtttcactgt gcggcgttgt 3670261 tccgccaagc atttttttca gctgaagcag cacatcctta tattcttctc gcttatcttc 3670321 aacttggtta gcagcctttt ccaaacattc cggtgttatc ttctgttcat gtatattcaa 3670381 gaaaacaact ccttttacag aaaaaaatag taggttatcg ttgaagaata gcacagatgg 3670441 ctcagatttc acataagaaa atagaaggat tttctacata agtgtccaaa ttccgacatt 3670501 catttcagat ttcccggtcg cactggctgt tacttcatga tttcccggga aaggaaaata 3670561 tcttgcactc aagacctctt ctccgttatt gataaagatt tccacagatg acgcgtcgag 3670621 aaacatgtgt acggtatgca aatccttgat gcggcaatgt ctcgcttctg ttctttttcc 3670681 gtcaaagctc tttcgttcca gcgtaacaat cccctcgtct ttatggaagg aaaacgtagc 3670741 cgttccgcgg atactgattg aaaagccaga ctccgtatga atgtcttcca gtagaatctc 3670801 agttctttca ggtttttcca ctggaagcgc accagatgat ccatgcatgt tgatgtgtat 3670861 ttttttctca tttctgcgca tggcttttag ctcaggcagc ggctgctgaa tcagcttctg 3670921 tcctgaaagc gtcagctgtc tcggcagcgt catgcagtga atccagtggc agtcaatggt 3670981 cggatgggac ccttcatcct gatcaggcac cgccatccat gcaaataaaa tccgccttcc 3671041 ctgatcgtct tcaagtgttt gcggcgcgta aaaatcaaaa ccttgatcaa gctccgtaaa 3671101 ttcaccatgc ttcagttcag gcttgttata atcgaggcgg ccgacaaaat aacctgattg 3671161 atatacgttc tgataacgga aaccgtcagc ctcaagccct tgaggcgaaa caatcagcac 3671221 atccgatcct tgaagggaaa acaaatcagg gcattcccac atgtatccaa aatcgtccag 3671281 cccgttgaag cccgcgccgg ttatcgggcc aagaaatctc cactctgtca ggttatcaga 3671341 agcaaacaac acagcctgcc ctttcaaatt ctctgtttgc gcaccaatca ccatatacca 3671401 tgtgccttca tgctcccata ccttcggatc gcgaaaatgc gccgtatatc cttccggaag 3671461 gcgggcgacg acaccctttt tctcaaagga cagcccgtcg tcagaaacag caaggcattg 3671521 atacgtttcc cgatttccat cctgatccct gacatttcct gtgtaaaaaa gatagagccg 3671581 atcgtctttc gtgacagcgc tgcccgagta gcagccgttt ttatcaaacc aatcactcgg 3671641 agccagcgca atctcttccc gcttccaatt cacaacatcc tgtgtcgtat aatgccccca 3671701 aaattttgcg ccgtgccccg tctgaaacgg ctgccactga aagaatacat gatagctgcc 3671761 cttccaataa atcacgccat tcgggtcatt cagcagccca accggcggca tgatatgaaa 3671821 atgctggcgg tgcggatcgc tgttagcgat gggctctttt ttctccactt cttcataagc 3671881 ccggcgacga agctcctggt catgtgctgt cattttttcc tctcctcatc ctcattaatc 3671941 ttcatgacaa atgctgcaat gaacgctgac actgccgcaa tcgccatgcc aatcagatag 3672001 tgaatcaagt tgctgaagcc aaacggagcc gcaatggcga tcatcggaat tcccgttaac 3672061 ccgtaagcgt ttgcagctac atgtgtaaag acgacatatg ccccacccaa tgcgcctccg 3672121 atcatcgcgg cgataaacgg ttttcggtag cgcagattga ctccgaatat gacgggctca 3672181 gtaatgccga gaaaagcgga aaatgctgcc ggaagcgcga tttcttttgt ctttgccttt 3672241 ttcgccataa agaagacggc aagacctgcc ccgccctgtg cgacattcgc cattgaccag 3672301 atcggcagca agtagttttt gcctatatct gcaattagcc ctgcctcaat cgcatggaag 3672361 ctgtgatgaa cgcctgtcag cacgatgagt gaatacgtgc ccccgaaaat cagacctgcg 3672421 acaaaaccgg catggtcata tacataagtt aaagcaaccg taatgccgga gccaagcgct 3672481 ctgcctagag ggccaatcgc gataaaagca acaaacccgg tgacaatcac agtaacaaat 3672541 ggtgtaacaa gcaaatccac cgcatgtgga accacttttc tcgtccattt ctctaccttg 3672601 ctcatcacat acaccgcaag caggacaggg ataacagttc cctggtagcc gagaagagcg 3672661 atatcaaatc cgaaaagatg catgtaatca ggtgtcgctt ccgccaatcc ccatggattt 3672721 aaaagattcg gatgaatcat gattcccccg atgaccgctc ccaagtatgg attgctgcca 3672781 aactcttttg aagcgctgac cccgattaga atcggcaaga aaatgaatgc tgcacttgaa 3672841 aacatatcaa gcagctgcaa aagcgcagaa tccttgctca tccaatgaaa cgcattgatc 3672901 atacccagca atcccattaa taggccgctg gctacaatag ctgggatgat tggaacaaaa 3672961 atattagaaa gcgttttcgc aaatctcgca gcgggattca gcttttcttt tgccgcatcc 3673021 tgatgattga cgtgttcttc acgctcgata tcagcttctt tagaaaaggc atcgaatact 3673081 ttattcacaa ggcctgttcc gaaaatgatc tggtactggc cagagctgct gaaagcccct 3673141 ttaacgccat caagctcttc tacttgtgct tgatctatct ttgattcatc tttcatcact 3673201 aaacgcagtc ttgttgcaca atgagccgcg ctgataatat tttctttccc tccgagaagc 3673261 tcaatgaggc gttttgcagt ctctttgtaa tccatctatt tctccccctt ttatttaaac 3673321 aaaaaagacc taaaattcgc caacgaataa aggacacagc gatccttttt catttacgca 3673381 aattttaggt cttgcctgct ttaccagtca caatcccgct tattcagatt aagaatacgc 3673441 tttcatcata aatcatgata gcgttttcgt caactatttt tttagttaaa tagtttgata 3673501 taacatgtag acaaaaattc gtaaaaatta attgtgaaat acttcacaat atcgtgctat 3673561 actatgctca atcatgaaag aaagcaggaa aagacaatgg aaactcaagc attacaaaag 3673621 gttgaacagt atgctttgaa aaaacaaaac atattcgctt caagcaaaat ccgttatgtg 3673681 cttcggtcca ttttggccag tatatttatt ggttttggca ttacagccgc aagcaaaaca 3673741 ggcagctatt tctttatggc tgattctccg tttgcctttc cggcagccgc tgtcactttc 3673801 ggggccgcta ttctgatgat tgcttacgga ggcggagatt tatttaccgg caacaccttt 3673861 tatttcacct ataccgcgct ccggaaaaaa atcagctggc gcgacaccct atacttgtgg 3673921 atgtcaagct atgccggcaa tttaatcggc gccattctgt ttgccatcct gatcagcgcg 3673981 acgggacttt ttgaggagcc ttctgttcat tcctttttga ttcatttggc agagcacaaa 3674041 atggagccgc cggcttccga attgtttttc agaggaatgc tgtgcaattg gcttgtgtgc 3674101 ctcgcctttt tcattccaat gtctctcaaa ggggaaggag caaagctttt taccatgatg 3674161 cttttcgttt tctgcttctt tatttccggc tttgaacaca gcattgccaa tatgtgcaca 3674221 ttcgccatct cgcttttgat cgagcaccct gatacagtga cactgatggg agcagtcaga 3674281 aacttaatcc ccgttacgct cggcaatctg accgcgggaa tagttatgat gggctggatg 3674341 tactacacac tgaatcctga tcaataaaaa aacttccaga gatcactccc tgcaagtcaa 3674401 agcggttatt ccgagagatc ttgaagacgc tggacatgca gcgtgatata gccggcctcg 3674461 gattccggca aatgtaattg atattcattt ttcaaaaact ccgccagctc cagcgcacat 3674521 tgataggcga atgaatactt tttttggatg aaataaagca tctcctcgtc catacgatgg 3674581 agcgcttcat ttgattccaa ccggctgacc gcgtatcgca aatgcgtgac aaggcgttga 3674641 taggaaatgc tgttttcatc cacctttcga ttaaagtatt gttttatttt ctctatcatt 3674701 tctttgatca tggtcgtatg cttcagcgct gaatacatgc tctccgcatc catcttcgcc 3674761 gtatggatgt gaagggcaat ataacccgct tcatcttcag gcagagacac gcccaatgtc 3674821 tcttttacat gtccgatcgc ccacaggccg atctcatatt cttttttata gagcgccttt 3674881 atctcatgca gcaatttatt ctgcacaagc agcccatttt gaatcctttc gatcgcaaag 3674941 gacaaatggt cggaaagcgc gatatgaatg tgatcgctca gcggcgccgc gagctctcct 3675001 tccgcatagc tgatgatatc ctcagctatt tctatatgct cctccggcag tgtttgcagg 3675061 atttgtttga acttttcatt ctcgtcgcgc acgacaaaga tcttttccac tttattcata 3675121 gggatgagat catttttctt tttttgaaaa gcgattcccg gtcccatcac gattttttcc 3675181 tgatcatcct cttttattaa agccgcattg ttgtttaata ctttatagat tttcaagagg 3675241 ttatctctcc cgccaatttg cttttgactg ggattttacc tccttttgac cgccatgtaa 3675301 agatgcgggc ccgctctctc ctgctttggc gattccttga aggcttgcaa acatcttctt 3675361 ttataaagcg cggcggcttt cgctttctgc ttttcttcct cattcacagc catccgccat 3675421 tcataaaacg aaacgagtcc tgcggcctgc acagccgcct ttctttggta tgtacgctga 3675481 gccgaataga ccgcggcagc cgcagttttt ctgtccggcg tcacccagtt catcaaaaag 3675541 accatccaca cccgtaaaga tacaagcaaa cgtttcatag aaaaacatcc ctccgcttct 3675601 ttttggcagg cagccttttt agcagcccgt tttctcagcc gcagcccgca agaaaagacg 3675661 gccgatttct tttctcgcaa actagcggct ctagcaaaac tcatgactct atgatagacc 3675721 gtggaaagag aattctttgt cacaatatga gtgaaaaaac caactagttt ttagaagttt 3675781 tgttgaaagc tgaaagaatt gaaatgaaaa ttggagaacc gctttgaaaa ctttatacac 3675841 aagttatccc aaagataaga acaacttaat cacaagagat atccacatgt ccacaaactc 3675901 tatctatatt ttgtatacga acgtatattc ctaactatat atatacacag gtttattcac 3675961 ttatacacag ggttctgtgt ataactcctt cgttatacac aaacaaaatc caataaatgg 3676021 tccaaatgac acaaggattt ttttgaattt tcaagaaata tatactagat ctttcacatt 3676081 ttttctaaat acaaaggggg aaacacattg aaaaagggga tcattcgctt tctgcttgta 3676141 agtttcgtct tattttttgc gttatccaca ggcattacgg gcgttcaggc agctccggct 3676201 tcttcaaaaa cgtcggctga tctggaaaaa gccgaggtat tcggtgatat cgatatgacg 3676261 acaagcaaaa aaacaaccgt tatagtggaa ttaaaagaaa aatccttggc agaagcgaag 3676321 gaagcgggag aaagccaatc gaaaagcaag ctgaaaaccg ctcgcaccaa agcaaaaaac 3676381 aaagcaatca aagcagtgaa aaacggaaaa gtaaaccggg aatatgagca ggtattctca 3676441 ggcttctcta tgaagcttcc agctaatgag attccaaaac ttctagcggt aaaagacgtt 3676501 aaggcagtgt acccgaacgt cacatataaa acagacaata tgaaggataa agacgtcaca 3676561 atctccgaag acgccgtatc tccgcaaatg gatgacagtg cgccttatat cggagcaaac 3676621 gatgcatggg atttaggcta cacaggaaaa ggcatcaagg tggcgattat tgacactggg 3676681 gttgaataca atcacccaga tctgaagaaa aactttggac aatataaagg atacgatttt 3676741 gtggacaatg attacgatcc aaaagaaaca ccaaccggcg atccgagggg cgaggcaact 3676801 gaccatggca cacacgtagc cggaactgtg gctgcaaacg gaacgattaa aggcgtagcg 3676861 cctgatgcca cacttcttgc ttatcgtgtg ttagggcctg gcggaagcgg cacaacggaa 3676921 aacgtcatcg cgggcgtgga acgtgcagtg caggacgggg cagatgtgat gaacctgtct 3676981 ctcggaaact ctttaaacaa cccggactgg gcgacaagca cagcgcttga ctgggccatg 3677041 tcagaaggcg ttgtcgctgt tacctcaaac ggcaacagcg gaccgaacgg ctggacagtc 3677101 ggatcgccgg gcacatcaag agaagcgatt tctgtcggtg cgactcagct gccgctcaat 3677161 gaatacgccg tcactttcgg ctcctactct tcagcaaaag tgatgggcta caacaaagag 3677221 gacgacgtca aagcgctcaa taacaaagaa gttgagcttg tcgaagcggg aatcggcgaa 3677281 gcaaaggatt ttgaagggaa agacctgaca ggcaaagtcg ccgttgtcaa acgaggcagc 3677341 attgcatttg tggataaagc ggataacgct aaaaaagccg gtgcaatcgg catggttgtg 3677401 tataacaacc tctctggaga aattgaagcc aatgtgccag gcatgtctgt cccaacgatt 3677461 aagctttcat tagaagacgg cgaaaaactc gtcagcgccc tgaaagctgg tgagacaaaa 3677521 acaacattca agttgacggt ctcaaaagcg ctcggtgaac aagtcgctga tttctcatca 3677581 cgcggccctg ttatggatac gtggatgatt aagcctgata tttccgcgcc aggggtcaat 3677641 atcgtgagca cgatcccaac acacgatcct gaccatccat acggctacgg atcaaaacaa 3677701 ggaacaagca tggcatcgcc tcatattgcc ggagcggttg ccgttattaa acaagccaaa 3677761 ccaaagtgga gcgttgaaca gattaaagcc gccatcatga ataccgctgt cactttaaag 3677821 gatagcgatg gggaagtata tccgcataac gctcaaggcg caggcagcgc aagaattatg 3677881 aacgcaatca aagccgattc gctcgtctca cctggaagct attcatacgg cacgttcttg 3677941 aaggaaaacg gaaacgaaac aaaaaatgaa acgtttacga ttgaaaatca atcttccatt 3678001 agaaagtcat acacacttga atactcattt aatggcagcg gcatttccac atccggcaca 3678061 agccgtgttg tgattccggc acatcaaacc gggaaagcca ctgcaaaagt aaaggtcaat 3678121 acgaagaaaa caaaagctgg cacctatgaa ggaacggtta tcgtcagaga aggcggaaaa 3678181 acggtcgcta aggtacctac attgctgatt gtgaaagagc ccgattatcc gagagtcaca 3678241 tctgtctctg tcagcgaagg gtctgtacaa ggtacctatc aaattgaaac ctaccttcct 3678301 gcgggagcgg aagagctggc gttcctcgtc tatgacagca accttgattt cgcaggccaa 3678361 gccggcattt ataaaaacca agataaaggt taccagtact ttgactggga cggcacgatt 3678421 aatggcggaa ccaaacttcc ggccggagag tattacttgc tcgcatatgc cgcgaacaaa 3678481 ggcaagtcaa gccaggtttt gaccgaagaa cctttcactg ttgaataaga aaaagccctg 3678541 ccgattcggc agggcttttt aaagatcagt cagcaaacgc ctcctgcaat aagcgatacg 3678601 atcggagctt atcttcaaaa tgatgcgtga tggtcaccac catgatttcc tctgtttcat 3678661 acgcgttact caaagctaac agccgctcct taacctgttc tttcgtacca acaatcattc 3678721 gatttcgatt atcagcaatt cgtctctgtt cataaggaga atacgtattt ttccgaacag 3678781 cttcatacga aggaactccc tctaaaggaa taccctgctc tcccgccaaa agtgtaaaat 3678841 caagcacagc cccaagctcc tctgccttct cctccgtgtc agcacaaaga acaaaaacag 3678901 caactgccgc tcgaggcgta tctcctaaca cagacggttt gaatcgcctc ttatactgtc 3678961 tgacagtacc ctctccgccc tctccattga taaaatgggc aaacatatag ccagcgccag 3679021 attcagctgc gagcagcgcg ctttctccag atgagccgag cagccacaca tccggagccg 3679081 ttgaaatatg cggcgcagcg gtcagattcg gaaaacggtg tttgtcatcc gccaaatcat 3679141 gcaaatacat ggtcagctcc ttaatttgct gcggatactg atcagcattg cgcttaccac 3679201 cgtcattcag cgcccatgat gcaatcggca ttccccccgg tgctctgcca agccccaggt 3679261 caattcttcc tggtgtcagc ccctccagaa cacgaaagtt ttcagctact ttataagcac 3679321 tgtaatgcgg cagcatgact cctcctgatc caacacgaat tcgctttgtt ttcgctgcta 3679381 tatgactgat tagcacctca ggactggacc ctgccagccg ttttgaaaag tgatgctcag 3679441 aaacccaaaa tctcttatat ccaaggtcct cagcagcttg ggcaagcgca acggtttgct 3679501 gtaaggccgt ttctgcattg ctgccctctg atactggaga ttgatctaat atacttaatg 3679561 aaaccatccc taccacctca tcctcatcgt atcactgatc ccctattttt tctccaaagc 3679621 cgctcacact gcttatcagt gtcccctatc attcgccatt tatttgtgaa agcatgtccc 3679681 tatttgtcgg aatatgttac acgtgaaaca taaaaacccc tccagacgga gaggtttgct 3679741 ttagttttta ttaaagccct tttctttcac gtagtcattt aaatacgtac gcggcttttg 3679801 cttcataaag ttcagtattt gatcggacca cgtttcttcc cgcttcccgt ttgttctttc 3679861 tctatagtaa tcagaaatgg ttttgtcata cgtattcata gtatgacgga aatcgtctgt 3679921 gttcacatta tacgtatttt catgataaac ggcctgcttt ggcaatctcg gttttttgcc 3679981 ggaaaggttc gcaggatggc ctactgccag tccgaaaagc gggagcacat ggtcaggcgt 3680041 ttgcagcacc tctgtcacct tgtccaattc attccgaatg ccgccgatat agcaaatgcc 3680101 aagccccatg gattcagcgg caatgctcat attttgcgct gccagcgccg catcaatcaa 3680161 gctaaccata aacatttctg tattctcgag cagctcagaa atatgttcac ctttttcctc 3680221 agccagttgt tgatggcggt acaaatccgc acaaaataca aaaaagtgtc cgttcttctc 3680281 aacgtaaggc tgattcccag caagcacgga cagctcacgt tttttctcag gatcagaaac 3680341 cccgataatc gaatatgcct gcacatagct ggatgtagac gcagcctgcg cacttttcac 3680401 taatgtatca atttcttcag ctgtcaaaag ctgatcagta aaagaccgga ttgaccgatg 3680461 attcaaaatg gtttcgattg tgttattcat cacaaaaacc tccttatcac tttttatcat 3680521 atccgaaaaa aagtgatctc aaaagtgaaa tgctctgcac aaaaaaagac agcctctgta 3680581 aaggctgtct gcatatcaag aattaaaaag ataacttctg tatttcgtca gctgcacact 3680641 tgcattatat acaatcccaa atccgattaa cgtggaaagt gtcgagcttc ccccatagct 3680701 gacaaacagc agcggaatcc cggtaacagg cataatgcca atgttcattc cgatattctg 3680761 gaatgtgtgg atcacaatta acgccgtata gccaacgcaa aagaaagaag cgaaacggtt 3680821 aaacggatgt attttgtcta tcagaacaac aagcctgtag attaaaaaga agaacatgat 3680881 gacaacaatt gcacagccta taaagccaaa tgactcacct attatagaaa agataaagtc 3680941 agtcgtactc tctggaacat aaaccttcaa attagaaata ccattaccta aaataccacc 3681001 agatcctatt gccatgatgg cctggtcaac ttgccagctg tcatttgaat cttcctgtgt 3681061 ctcatttgaa gcagacaccc aagaagtgac ccgcttaatt tgataatcct gtattccaac 3681121 tgatttagca acgtcaggaa agtttatcat tactaataaa attaatgaaa tgagtaagat 3681181 acctgaacca gctatgatcg caatcaattt ccaatttatc cctgacataa aaaccattac 3681241 aagaacgata aacatacata ttcccgcagt cccagcatcc tgcatcagga taagacctac 3681301 aggaataact gcgacacccg caatctttaa taacaagtgg atatcatccc taagcgtccg 3681361 aactccttta ggatttgctt ttccaataac tgaagcaagc atcataatca aaccaacctt 3681421 cataaactct gacggctgta ttgttattct accgatccta aaccaacttt ttgccccttt 3681481 aataacaggt gcaatagact cgggactgat tttaagaata atcaaagata aaataccaat 3681541 gataaaaata tataaactta acttttcaag ctgttctaaa tcaaagtaca aaagaactgt 3681601 aatggctaca gcccccaaaa gataaaacac aatttgctga atccaatccg tgttcccata 3681661 ctgcccaaac tgaccggcag catatattga tactacgctt ataataaaaa acacaccaaa 3681721 tataaaaatc aaatccccct ggtaaaaggg gctttgctgt ttcttatatc gactcattct 3681781 atcccgcctt acattttcat cggaaaatca ctaatgttta ttatacatga accacgttca 3681841 agatgacacg tgaagctcgc ttccttttat gttttttcag catttgcggc gctttttcag 3681901 ctacacgaaa tatgacgtat cataaaccga aatgtttcga ttgacacaaa acttttcaaa 3681961 tgaaaaaaac gccataccaa tagaatttgt taaaaaacga atgcgataat gtgttatgtt 3682021 cccaaataat gtgatacctc atatagaaat agctaaaaat tcagagcccc atgcccatac 3682081 attctcctag cacattaaac gaaaaaataa gacgatagat ccagtccatt tctgcaaaaa 3682141 cacgtatcaa tttctggaaa acatggtata ataattgtaa cagaatgttc aaaaaacaat 3682201 cacaaaacag acacaactca gttcctctat ttcatttttg taaacgttat cacaaaatga 3682261 aaggagacgg gtatgatgga catgtttttt gcttacttat tggttgccag cgcaacgcct 3682321 ctctttattt ggcttgataa caaaaaagtc gcactctcag ctattccgcc aatcatttta 3682381 atgtgggtat tcttcttctt ttacgcaaca gaaagccttt ctccacttgg acacactctc 3682441 atgattatct tgtttgccgt taacgtcatt gtcgctcata tcgccgcatt tatcatttac 3682501 ggccttccgt atcttcgcag aaagcgaagc agctgaagac agcaaaaaac cctcttccac 3682561 tgaagagggt tttttgtatt attcgttatg gcctgaatgc tctgagtgtt cagcgcctcc 3682621 aggaggattt ccgtccatat ggtcaccatg gtgatagtga gccgcgaaaa tccagatgga 3682681 tccaagtacg ataacgatcg cgccaaagaa tccgaacagc gtgtttccga cttggatcgt 3682741 gccgttttcg ctctctgtca tatgcatgaa catgagaagc tgcagcgccg cctgaatgaa 3682801 ggcgaagccg aagataatcc aaagttttgc tgatgagctc aggtcagtat acactgcaac 3682861 ccatagagcc agcagggtca aaacgataga caggataaaa cctacaatgt gtttccatgg 3682921 aaagtgactg tgttcagcag atttgtttgc cattttacag accccccaat cccatgagat 3682981 agacacctgt aaagatgaaa atccatacaa catctaagaa gtgccagtac aagcttgaga 3683041 taaagatttt agatgaagtt tgcggagtta agccgcgttt cttcaactga atcagaattc 3683101 ctgtgatcca gaaaatcccg attgttacgt gagttccgtg agttccaagt aaaacaaaga 3683161 atccagacca gaacgcactt gtactgagag ccgctccttc atgtacatag tgaacaaact 3683221 cgttgatctc gcatccgacg aagccggcac cgagaagaag agtgataatt gtccaaatga 3683281 ctacgccttt taaacttccg cggcgcattt catgaacagc gatcccgcag gtaaagctgc 3683341 tgatcagcag caagaacgtc ataatcatta ccagattgac ttcaaatagt tcgtctggca 3683401 agacacctcc agctgttctg tttttaagaa cgaagaaggt tgcaaatagt gttgagaaca 3683461 acacaatttc tgcccctaaa aagatccaaa acccgagaat attaagtctg ccggtttcag 3683521 attgatattc cataggcgcg ttagaattgc cgtgttctgc atgttccata actcacgcct 3683581 ccttattcgg aaatctttct ttccgtctct tttatttcat caacactaat gtagtagccg 3683641 ttgtcgtatt cgaatgaacg cagaaccatg cagagcagga ctccgatcaa tccgactacg 3683701 cccatccagt accattcaaa gacaagtcca aagcctgcga gaccgaaggc aacagacata 3683761 aagaacggtc tgcctgagtt gcttggcata tggattttct tgaatttgct ttcagggtat 3683821 aattcagttt tttcttcttt catatgcagg aatgcatctt gagatttgac ttcaggaagc 3683881 accgcaaagt tgtaatgcgg cggaatcgca gaagaagtcg cccaatcaag cgtacgtccc 3683941 acaccccatg aatctccgct gatttcacga gtagagtaac ggaagctgta gtagatgtta 3684001 tagcaaagga ttaagaatcc tacacccatc atgaaagctc cgactgttga gataaagttc 3684061 aatgttgtcc agccgtcatt cggtccgtat gtgtaaatac ggcgcggcat gccttgaagc 3684121 cccaagaaat attgcgggaa gaaacaaata ttgaacccga tcataaagat ccagaagaac 3684181 cattttccga ttctttcgtt cagcttgtgg ccgaacattt ttggatacca gaaaataaat 3684241 ccggcgaaac aagcaaatac agtacccgca atcagcacat agtggaagtg agatacaagg 3684301 aagtacgtat tatggtattg ataatccgct gctgccatcg caagcataac ccctgtaacc 3684361 ccgccgataa cgaagttagg aatgaacgca agcgcccaca gcataggtgt tgtaaagctg 3684421 attcggcctt tatacattgt aaagagccag ttaaagattt taaccccggt tgggattgag 3684481 attgccattg tcgtaattga gaagaatgag ttaacggacg cactgttccc cattgtgaag 3684541 aagtggtgag tccaaactaa gaaactcaat acagagatgg cgataataga accaaccatc 3684601 gctttgtaac caaacaattg ttttcttgca aagcttgaga tgatttctga gaaaatacca 3684661 aacgccggaa gaataacgat atatacttca ggatgtcccc aaatccagaa caagttagcc 3684721 caaagcatcg gcataccgcc tgcttccaat gtgaaaaagt gagcgccgaa caaacgatca 3684781 aatgataaaa gtgctaatgc tactgtaagt acagggaacg caaacacgat aataaccatt 3684841 gtgatcagtg ttgtccatgt gaacatcggc atacgcatta atgtcatgcc ttttgttctc 3684901 atttttaaga ttgttaccat aaagttgatc cctgtcatca gggtaccgat accggcaatc 3684961 tgaagtccga ggaggtagta gttctcaccc ggcccagggc tcatgtcgtt acttgcaagc 3685021 ggcatataac tcgtccagcc tgcgttcgga gaacctccga taacgaaaga aatattgaaa 3685081 agcatcgccc ctacaaagaa cgtccagaag ctcaggttgt tcaagtaagg gaacgcaacg 3685141 tcgcgggcac cgatttgaag aggcacaaca acgttgataa gaccgattaa gaacggcatc 3685201 gccatgaaga tgatcatgat tgtaccgtga gttgtaaaaa tttcattata gtggtttgag 3685261 tctaaaaaac tgttattcgg aagcgctagc tgggcacgca tcatcagacc gtcgacaccg 3685321 ccacggaata acataattac agcagatata atatacatga ttccgagttt tttatggtca 3685381 acagtagtta tccattcaga ccacagccat ttccactttt tgaagtaagt cagaacaaaa 3685441 ataatggcaa tggttgaaag cgcaatggaa acttgtgcgc ccagaattaa tgggtcacca 3685501 gttacgaaaa attcgtccca tttgaatttc atgcaggctt cctcctttcc tgatcaatat 3685561 cattcttctg tatcatcaga cttcttaaat tcgtttttct ttacgttttc aaacggatct 3685621 gttttagaat gcggtgaaac ggcttgatag ccaaggcgtt tgcgcgcctc catcgcgtac 3685681 tcagcgtctt gtccgtgatc aacgtatttc aagtgagtag aagagaacgt taattcgtcc 3685741 acattttcag gaagcatcaa ttcatcatac ttctcttttg tcagcttagg agcctcgttc 3685801 tgagtctttt tcacccagct gttaaagtct ttttctgtga ctgcattcac atcaaactct 3685861 tggtctgcaa aatgttcacc tgtgaagttc gcgttgcggc cttcgtaagt acccactttg 3685921 tcagcctgta agtattgatc catcagcatt cctgccatcg catatttttg ccctccaagc 3685981 tgaggaatcc atagcgaagc cattgaatct gcagatgaga ttttgaacaa gatcgggcgg 3686041 tcgacaggaa tgtttaagta gttgaccgtt tcaatatcct gttcagggta gctaaatacc 3686101 catttccagt ctaccgaagt agcataaaca acaagaggct ctttgtcttt tgttgcttca 3686161 ggagcttttt ctaacgaata tatcgtctgt actgttggca cagaaagtgc aatgacgatt 3686221 aaaattggga tcactgtcca gactacttct aaaaacgtgt taccgtgaat ttctgggtta 3686281 taagatccat tatctttgcc tttacggtcg cggtatttta ctaaaataat ggtaaataga 3686341 acaaagacga ccccgacgat aaacagcata aatccgatag ataacaggat taaatcactt 3686401 tgctgttcag ctacaggtcc tttcggatct agtactgaag cattgctgca tcccccaagg 3686461 acgaaaacca cagttaacag cgctaataca agcaacggtt ttaatgctct gaacaagaag 3686521 atcaccatcc ttcctattga tgtaataaat ctgaagtgca tacttcctca aaatcttttc 3686581 tctactttgt tatgctatca aaaacttcac ttattagctt tattttttta taaacttcat 3686641 cccattttcg cttaaatgtc ataaaatcga caaaaattgc tccaacttta ttcacatcta 3686701 tcgcttaaga tgaaaagttt ctagttattt ccgcatataa agtaaagaaa gatgatgaag 3686761 aactaattct gacaaattaa ggtttaccac aataaaaaac ttaggtcaat caaaaatttc 3686821 attttgttaa actttctaga taggaattat tttttcctcg tctagcatct tttcacacgg 3686881 ttaccatttt aacgcatcaa atattgaaag aaaaggcgca atgaagagcc aatatgctct 3686941 gaattgtccg tattttttta tgagagcatc cagttgttta tcttatacaa aaaagaggaa 3687001 tgatataagc aaataaataa aaaataggat gtgttgcatg atgagttttc ttatttcact 3687061 tatcgtcgct attattatcg gatggcttgg aagcctgttt gtaaaaggag atatgcccgg 3687121 aggaattatc gggtctatga tcgcaggtct tataggcgcc tggatcggac acgggctgct 3687181 tggaacatgg gggccgcacc tagccggatt tgccattatt ccagcggtaa tcggcgcagc 3687241 cattgttgtc tttctagtaa gcctgttaac cagaaaaaga ggataaaagc agcagcaccc 3687301 gaagcgtcag cgctttgggt gtttgttttg ccataaaaat cgaaaaagcc tcaaccctag 3687361 cggttgaggc ttttgactgg tttggcgccc aactgatcga tgaaccttct gaaggcctgt 3687421 tttccctctg ctgtctgctt aaatacaccg gcgtgttcaa ggatgcgcgc gaatacatgt 3687481 cccagctctt cttttatgac tagatctacg ttctcttttg ttatggttct tttttccatc 3687541 gtccgaagag cccactcact atgctttgca gtgagcggat tttgttctaa ggctgttttc 3687601 ggatcagcag aacatagcgc cgctgccgtt tctttcattt cctcctgtaa gcggccaggc 3687661 aatatcgcca atcccatgac ctcaatcagg ccgatatttt cttttttaat atggtggact 3687721 tcttgatgag gatgaaatat tcctaatgga tgctcctcat ccgtccggtt gttcctcagt 3687781 acgatatcga gttcgtacaa gtctcccctg cgccgcgcaa tcggtgtgac cgtattatgg 3687841 ggcgtatcgc ctgtataggc ggcaatgccg gctttttcat cggaatacgt ctgccacgtg 3687901 cggaagatat ggtcagcagc ttcggcgaca tgacccggtt cgtctccttg gagcctgagc 3687961 acagacatcg gccacttcac taagcccagc gacacgccgg gataatcatt taattcataa 3688021 acgtcttccg cttctgcacg tgccattgga aaatcatgcg cgccgccttg gaaatgatca 3688081 tggcttagga tgctgccgcc gacaatcggc agatccgcgt ttgaaccgat aaaataatgc 3688141 ggatattggc caagaaatga cagcagcctt tcaaatgttt ttttgctgat ctccatcggt 3688201 tcatgttcac cttttaagac aatgcagtgc tccggataat agacatatgg cgagaattgc 3688261 aggaaccatt gttcgtcctc aaggatgacc ggaatgattc tgtgattttg ccgggctgga 3688321 tgattcacgc ttccctcgaa gccgacattt tctttacaca gcaaacacat cggataattt 3688381 gtctgttcct gctcttttgc agccgcaatc gctttcgggt ccttttcagg ctttgatagg 3688441 ttaatggtca tttccagctc gccatattcg gtcggcaccg tccaatgaac atttttggcg 3688501 attctgtcag tccgtatata atagacatcc tctgaatatt gatagaattc ctttgtcgcc 3688561 tgttttgggc cgtataatgc ttttgtctct tcaaatttgc gaatgacctc ggacggggca 3688621 ggcacaaaac agcccatcag ctttgcgctg agcaggtcac ggtacgtatc tgtatccgct 3688681 tccattcggc cggtttcggc agcccattta tagatgggag ctagcaagtc cggcaggctt 3688741 tgtgactgct tgatgctggt gctggagttc ggctcgggat gtgtgatgcc cagcgcttca 3688801 taaagacggt ttctcgtata ttcccgatcc cagatcgaaa tcaattttcg ttccaggcca 3688861 tactcaagca gctgttccag atgttcaata atactcatat gtcactcccc ctttagttct 3688921 ctcgctccct ctccgatatc cgcgacataa aagtccgctc ggagccctgt tttttcttga 3688981 tatctgtctc caaccttctg aataaaatca tcaacgaact catcttttac aatgctgatg 3689041 gtgcagccgc caaagcctgc tcccgtcatt cttgatccaa ttacaccttc gtgatcccat 3689101 gccgcaaaca caagctcatc aagttcaggg catgttactt catagtcatc cttcaatgaa 3689161 aggtgggatt ccttcattaa ctgcccgatt tcatctatat tgttctcttt gaacatatgg 3689221 gccgtcttaa tagcacgatg attttcgtat acagcgtgct ttgcccggcg tctgttcgtt 3689281 tcattttgga tcaggctgga atgcgcatcg aaatcagaag gcttgatgtc gcccagtgcg 3689341 gcaatatcga ggcctttttt cagatcaagc aatgcatcat tgcattcttg gcgtctcgta 3689401 ttatagctgg agtcagccaa tgtccttttt ttgttcgtgt tcgcgatgac cagcgcgagg 3689461 cctgagacat tgagtttgct atattcatag tcaagcgtgt cacagttcag cagcatcgca 3689521 tgatgttttt tccccattcc aattgcaaat tggtccataa ttccgcaatt gacgccgata 3689581 aaatggtttt ccgcatgctg cgccattttc acaagctcaa gcgcatctac ttcaggatga 3689641 aaataacttt ggagcacgac ccccatcagc agttcaatag aagcggaaga cgacagtccc 3689701 gccccgtttg gaatattccc tgaaaataca atgtcaaagc catggggaac tgcatatccc 3689761 ctctgttgaa attcataaat cacgcctttt gggtagttcg cccagtcgtc ttctttttga 3689821 tagcgaatgt cgtcaaggct gcattccttg atgcctgcgt ttctaaagtt atctgaatac 3689881 atccggacaa gcccgtcgtt tctttctgca acagcagcat atgtacccat tgtcagcgcg 3689941 cacggaaaga catgcccgcc gttatagtct gtatgttctc caatcagatt cactcttcca 3690001 ggtgcgaaaa aaaaccgtaa cccctctttt tctccgaata cacttgcaaa tatccccttt 3690061 agctcttccc gcatgtgcaa tcacctttct ggtttttatt ttttattccc cttatttctt 3690121 catagaaaac ggcagatcat atgctgcagt cctctcatac cccttcttct tttgtttttt 3690181 taaagacgag ccatttgctc gcaacatagt tgacgacaac aatgaccgcg ttgtcgagta 3690241 ttttggccaa ggtttcattt gtattgaact ggccgacaag aatgatcatc atgcctaaat 3690301 ctatgccgag agacaggacc cgaacgctga aaaaagcagt gagctctttc agcaggctct 3690361 gcagatcatg tgttttttgc tgaaacacat ataatttatt tgttatgtaa gcaaacagca 3690421 cggacaaaat ccaagcggca acagtggcgg ctttgtaatc cacattcatg atctctacca 3690481 atatataaaa gctggcgata ttcacaatgg ttgtgaaaac ccccataatg atatacataa 3690541 ttatttctct atacttcact gatgttcctc gctttctgaa aaacttttca aaattcttgg 3690601 cctctcgtgc tctctgtcta aagtaaaaaa taccgagagt gcgtctaaaa agctgcggaa 3690661 ggtggctggc tggcccaata catatgattg tttgatgatt ccgtcgagga ctgcacatat 3690721 tattttagcc gtatattcag gatcaataca ggcgtcaatc agctttctct ccttcagcca 3690781 cttaatatat aacacatttt cttccaccca caattcgtac agccggacat aggccttgca 3690841 tttctttaag actttatatg tcggcatgtt catggcaaac gaggtgatgt cccacgacgg 3690901 cttatttatg taataggaat aaagcagttc tgcagcgtgt tttgcagcct cgtccaatgt 3690961 cagcgatttc actgactccc gctccatttg atcaagatac cctataatga tctttttttt 3691021 catctgacgt ttttcgagaa ggtacagcag aaaatcgtcc ttgctgacaa aatgaacata 3691081 aaatgctcct ttgctgtacc cggcggctct gctgatatct tctacagaaa ccggatcata 3691141 cgctcggtca atcaacaaat tcacgccagc gtctataaaa ctttcaaatg ttgcttctct 3691201 tttaatttga aatttgtttt ttttcatatt tttctcctgg cggtaatgat tacccttatc 3691261 ttacaccgga tcaatcttta gcggtattta tttctttaaa cggttatgct attcggtttc 3691321 ccaggggtca tttttaatag gctaaatgat ttattttcat ttacatacta tccagtcagt 3691381 atttaattgt ttattattat aaataaggtc cattggttat attagtcatt tttttaggga 3691441 ataggtaggt ggtttttcct tcagtttgtg aacaccgagc aactatgtgt gaaatttgtt 3691501 gtactcgcct ccatcatcgc gctggcttgt cttttattgc ccgcatgttg caggaaaaca 3691561 ttttatacaa ttggaggtta ctatgaaaac tcatgttaaa aaagatttgg acaaaggttg 3691621 gcatatgtta attcaagaag ctagatccat tggattaggc attcatgatg tgaggcagtt 3691681 tttagaatct gagacagcat caagaaagaa aaaccacaaa aaaaccgtcc ggcaagacta 3691741 gtccgaacag gcggatctat ttacctctgg cttttctatc acctgatctg agttttcacc 3691801 atatcctcta ttcaaaagca aatcgctgcg ctgagcttga ggacaaacgg tgtgtcagct 3691861 aactacgaca gacagccggt gatgcgatca cctcttggca catgcattgt cataaagagg 3691921 tgatgcgaac atgataaccg tgctctggta aacagcagct ttgctgagaa caagctgcat 3691981 tcggtgaggt tttgaaagca aactcgttta tacacggccg agcttgaaaa ccttcgcctg 3692041 tctttagacc actgtgttca cctcttcacg acttccttct tttttcatcc tccagctatt 3692101 gtacaacgca taaatcggac tttcagtaca tacctattgg tgtacctttt tgcttacgtt 3692161 tagcgaataa aaggaggaaa gccatgtaca aagctgatta taaacagatt gctgcaacgc 3692221 cgtcttttca agctttttta aagcagaaac gcgcttttat tgttccttct gcgattttct 3692281 tttttgtttt ttatttttca ctccctgttt tgacatctta tttcaccttt ttgaatgcac 3692341 cggccattgg agctgtttca tgggcttggc tgttcgccat cgcccaattc gctatgacct 3692401 ggatactgag tactgtgtat tcccggagag ccgcccattt cgataagtat gtaagcgctt 3692461 taaaagagga tctgaagggt gaacagacat gaatatgact gcttttttat tatttttggc 3692521 gattgttggc ctgacgctta ttatcacgta ttttgccgcg aagcggacga aaacgacgag 3692581 tgagttttat acggcgggcg gcgggctcac cggcgttcag aatggactgg caattgccgg 3692641 tgactacatg tctgccgcct cgtttctcgg gattgccgga atgattgcgt tatatggatt 3692701 tgatggcttc ttttacagca tcggttttct ggtggcttat ctcgttgtct tgtacatcgt 3692761 ggcggagccg cttcggaatc ttggaaagta cacgatggca gacatgattg ccgctcgctt 3692821 taaagaaaag aaaatccgcg gtgtcgcggc tctcaatacc attgccatct ctacttttta 3692881 tatgatcgcc cagctcgtgg gggcgggcgc gctgatcaaa ctgcttctag ggctggatta 3692941 taccgcggct gtcctcatcg tcggagtgct gatgaccatt tatgtcgtgt ttggcggcat 3693001 gatcgcgaca agctgggttc aaattattaa agctgttttg ctgatggccg gcacactcgt 3693061 gatttcgatt atcgtgtttt cgaaattcgg ctttagcctt aataccatgt ttgaacagat 3693121 gaaaacggct actccgcttg gcgctgattt tttgaacccc ggaaataaat acaaggtgcc 3693181 gcttgagacc ttgtcgttaa acttggcact cgtgctggga accgccgggc ttccgcatat 3693241 attgatccgg ttttataccg ttaaggatgc caagacggcc cgtacatccg ttgtgtcagc 3693301 gacatggatt atcggtgtgt tttacattat gacggtattt ctcggctttg gtgccgcggc 3693361 atttgtcggt tttgacgcga ttacggcggc tgatcaagcg ggaaatatgg cggctccgct 3693421 tttagcaaaa gcgctcggag gagactttct gttcgcgttt gtatcagcca tcgcctttgc 3693481 caccattttg gctgtcgtga cagggttggt gctgtctgcc gcctcagcat ttgcccatga 3693541 tatttacagc cagatcatca gaaagggaga agcaactgaa aaagaacaaa tgaaagcggc 3693601 cagatgggct tctgtcgccg tgtcagtgct ctcgattctc cttgcgattt ttgcacaatc 3693661 cttaaatgtg gcgttccttg ttgcactcgc gtttgcggta gccgccagcg caaaccttcc 3693721 gctgattgtg tttacagtct tctggaaacg attcaatgcc tcaggcgctt tatggggcag 3693781 cctgacaggc ctgatcagcg cgcttgtgct ggtatcgatg agccctagtg tgtgggaccc 3693841 ggccggaggt gctattttta ccggtgatcc gctcattccg ctatctaatc caggaattat 3693901 ttccatcccg ctcggctttc tcggcgcgtg gctcggaacg gtgctgtcgt ctgataaaac 3693961 aattgatgaa gatacgtttg cagaaattca ggtgaaggcg catactggcg tccatatgga 3694021 acaggaataa aaaaagctct ctttatcgag agctttttcc ttactttttc ttctgctcgt 3694081 cagaaatcgc tttttcaaat acatccttgc cggcagcacc cggaattaca gtgtcaccga 3694141 taataaaggt tggaacggct gtgatgtcag cctcttcata ggcgtgcttc aaggcttggc 3694201 gctgcacgtc ctgatatgtt cttgtttcca gtgctgattt gaatgatgca ccgtctaatc 3694261 ccacttcctc ggcgagcttc gtcaagatgt caatatcgcc gatattttgg tcctcctgga 3694321 aaaatgcctg aaagacacgg gtgttgtatt catgtccttt attgtattcc ttcgcaaaat 3694381 ggaagccttc aaacgcgagg tctgtatacg gatggggcga gacgtttgga aaattgatct 3694441 cgactcctaa tttctccgcc attggctgaa ttgatgtctg ccacatgtac tgtttagaag 3694501 gatcattgac cggatcaagc tgaggagatg ggcttgggcg cagttcaaac ggcatccact 3694561 cgacttcaac atcctttcct tttatcgctt cttcaaaagc ggcttttcca acaaaacaaa 3694621 atgggcagac gtaatctgaa taaactttaa tgtgtactgt catgataatc tcctttcata 3694681 ctaaattgat tttaaactgt aacaattaaa gttacaactg ttttttaata aagaagccga 3694741 tttaggcttc tttcagattg atgacaaaat cctaaaaagt tttaggattt tgtcatcctt 3694801 tcagcgtgat tgaaaaccct tgaagtctag gaaagccgag cattggagcg gagcgaatgc 3694861 tctaattcgt gagcaccaac gcacaggctt gacaacgaat gcgagggttt gtcgacacgc 3694921 tgaaagaagc ctgtaaaggc ttcttttatg attccagcaa acgctgggca atatattctc 3694981 cttttttgca gccgcctggg catgcgtata aagcagaacc gattgtttgt gtatattcgt 3695041 ttaacgcatc ctttgctgaa agagccttca gcatcgggat aaactgattg tcgggatttt 3695101 tttgaaaact gataaacagg agacctgcat ccatatagcc ggttttcgga tcaagtcctt 3695161 ctgtgtaaga gaaagctctt cgcaaaattt gtttcccagt agatttcgct agactgacgt 3695221 gtgaattaga cggaatttga ttcagcttca cgggatctgt ttcctttttc tgcccaaaag 3695281 gcgcccccga gctttttctg cggccgaagg tatcctcttg gtccttgagg gaagagcggt 3695341 cccatacctc aaggaacatt ttgattttcc gaaaagccat ataggtgccg cccgtcatcc 3695401 agtcaggctc accagactga atccacacga tcgagttcat caacgtgtca tccttcgtgc 3695461 tctggttgcc tgttccatct ttaaacccga agaggttgcg cggtgtttca ccattttttc 3695521 caccgcttaa aaagcctttg ttcacaaaac ggacctcaca agtgccgacc gcttgattta 3695581 gcaggttacg cagcgcgtga aacgccactt gctcgtcgtc tgcacacact tgaatgcaga 3695641 tgtccccgcc tccctgcttt tcatccaggt tgtcattggg catcgctgga agagcggcta 3695701 ggtgcttcgg ttttttgctt ttcagtccga agcggtcctt tccgtctttt tcaaaaaagc 3695761 caggcccgaa tccgaatgtg accgttaagt tggaagggga taaatcagca gactcacctg 3695821 tatcctgcgg cggcagatac tgatttctct gctccgctga cattttcttg ccagacgtca 3695881 gcatctgtgt gagacttgtc cagtttctaa ataacgtaat gatgtcgctt ttgtcttttg 3695941 ctgttacatc cagtgcagca aaatagacat acgtctgatg ggcagttgtg attccggcct 3696001 gatgctttcc gtaaaacgga acaatctgct cctcctcttt ttcatccttt ttcgatggct 3696061 tagccgcagt ctgaacaagc ggagcgagac cgccgagacc gctggcaccg atcgcaacgg 3696121 ctgcccccgc catcgctccc cattttaaaa tgtcccgtct gtgaatttgt tctggctttt 3696181 tctgttcatc gctcatgatg ttacaaaact ccttttatag cacattcgca atcttcgaca 3696241 tggtttcaga aagagtcgtc agcttagtgc tcagctctct gatttgcttt tcacttaatt 3696301 tatcataaga cgtataggac tgatcatttg ttttgtattt tgccattaaa acttcaaatt 3696361 cgctgaactc cgtatccagt ttttccgtca agtcggagtg atcttttaca agcgcgcttt 3696421 tcactgtttg ataaacggct tcggagcctt ccacatttgc cataaggtca actaaatcaa 3696481 ttcgtgagta gcgctcttct tctcccgtga ttttcgaaat tccggcttcg ttcagaagct 3696541 ccatcgcgcc tgcaacaatt tgttcaggtg ttaatttcag tgattgaatt gaaccgtcaa 3696601 gctcttttac atccttgaga agctggtcag ctgttgcctt ttccccggaa atatcttgat 3696661 ccttccaaat ggccttctca agcttatgga agcctgtcca tttgtctcct tcttcaacat 3696721 cgttttctcg tgcgtcaatt ttcggatcaa gatctccgag gctttcagcg atcggttcga 3696781 ttcgctcgta ataaacacgc gctttcgcat ataacgtttt ggacttttcg atatcgccgg 3696841 atttcacagc acccgtaaat gcttcagtcg ctttgacaag ctggtcactc tgctctttga 3696901 catagccttt atactcatcc gctgcttttg ccagctgatc gctagccttt ttgccgctct 3696961 tcttcgcttc tgtcaggtct tctaaggatg ctttcaatga ctcggattct gtcttgattt 3697021 ttcctgcatc cggtttgtct ttttgcgctt ctgtgtagat tggctgaaga tgcttttcga 3697081 tttctgtata ttcgaatgga tagtcgctgc gaatatcgtt ttcaaaggaa agccagtagc 3697141 tgtttaactc tttccccttc ttttcaatct ctttttggtc tcctttttcc actgagtcat 3697201 tcagcttaga aatgatggtt tccattttat ttacggatgc ggtgatttct ttagtgaccc 3697261 cgcttttttc agatgaagct ttttctttgg ttgaagatgt gtcattggct ccgcagcctg 3697321 cgcacagcgc aaggatgcat ccggctgata cagcgatttt tgtgaaattc attttgtcag 3697381 ttcctttccg tttgtaaaat gttttgccgc ttctgaaaca agcgcaatca gtaaaaagag 3697441 taaaatcaac atttgcggaa tcgtgctgta cacagacgga taaattccta gcaccgatac 3697501 agacggcagc cagctttctg catcagacgg aagaatgccc gccagttgaa ggctgtgaac 3697561 gccggttccg agaaatttca cgcacatata caggacaacc gccattgata gaagaaaaaa 3697621 cggcttcaat ggaatgcgca ttccgagctt gatcatcaga acaccgacga tgacgagaac 3697681 gataagccct gcggcagttc cgccgatcag ttcagtgagc gggagcttcc cgacaagccc 3697741 gatgaaaaag atgaccgttt cgagaccttc tcttacaact gccagaaatg caatgagcgc 3697801 aaaggaaagc aggcttcgtt tttttagtgc ctgtgacttc tggatattga ttttttctct 3697861 ccatttatcc attgaggcgt ttctgtgcag ccacaccccg acatacaaaa gcatgacagc 3697921 ggacagtacg ccggtaacgc cgccaagcaa gaaattgttt tctccgaata cactggagga 3697981 gaacagaacc gtgacaccga tgccggctgc taaggaaaca gccatgccgg cggacgcccc 3698041 gccccagatc catgtcgagg aacgcgtaac ccgcgctttt tttgtcatgg ttaatagcgc 3698101 tccgatgaca aggagggcct ccattccttc acgaaccggg atcagcgccg catcccacca 3698161 gctgtagctg cttgaagcga tcggctcgag caattgaatc atttcgtcaa tttgctttga 3698221 taccttttca ggatggctgc cgatctccgc cttcatcagc gccagatttt cctccgatgt 3698281 cgtataggct tctttcgatt gggacacgac atctccctca acagcgagcc aggatgtaac 3698341 taaattgtcg attgcggatg acgcttcatc caattgtttt ttttctatga actgttttgt 3698401 gtctttcaag ctttgtatat aggctgttaa ggacgccctt gattgacctg aggatgtctt 3698461 tttcagcacg acagcctgct gataggtttc taaatgagac gcaagctctt caagctgtgt 3698521 tttgagctta cgtgcgtctt gattgataaa agaaagagaa atcatcgcga tattcgcgtc 3698581 catttcactg tgagaagaaa ggttttcttt cttaatagaa ggttcttctt ttttccactt 3698641 cgccttgaag gtgtcaaacg tttgttgtgc cgaatccata tccccgtctt ttacggattt 3698701 gatcatttgc ttgtttaatt gaattaatgc ggcgatcgga tcatcttccg catgtgccgc 3698761 agaaccgaaa accatcaaca agctgaatag aataagtgcc agcccccgag ccatcatgtt 3698821 cctcctataa ttgaaaatga ttatcattgt ataacataat catagccagt tcctgtcctt 3698881 tgtcaattaa aatttgaagg tctgaaaacc ttgatggaca gcaaaaaagc tgtcctttta 3698941 cagaacagcc ctttgaagga aaatgaacga ttatcttcct gttttatacg tttgaatttc 3699001 ctcacgaaac ttgcgtgcag cactctcagg atcctccgcc tgactgatgg cgctgatcat 3699061 actgacgcca tcggcccccg cttggataac aggtgcggca ttatctattg tgattccgcc 3699121 gatgccgaca attggaatgc tgatgccttg gcggcgcact gcttcgataa gagatacacc 3699181 ctgtaccgct ctcgtatctt ttttcgtttc agtcggatag atcggcccaa gcccgacata 3699241 atccgctccg tcttcttcgg cttgcttcac ctcagacatc gtatgggcag aaacgccgag 3699301 aatcatatca cctatggcag ctcttacctc tttcgcattt gcgtcttcct ggccgatgtg 3699361 gataccatca gctttcagat tcagagccaa ttccacatca tcattgacaa tgaacggaac 3699421 accagcttca cggcaagctg cctgcgcttt ttcagcaaat ttaatccgag cctctcctgt 3699481 cagcgcatcc ccgccttttt cacggaactg gtacagggtg gcaccgcctt ttaacgcttt 3699541 ttgtacaact gtaacaggat cggctttcgt attgtttgac cccataatga agtatacaga 3699601 taataactct ttcatcattt cccgagaaat acgagtcatg agacagtcac cctttctata 3699661 gtcgcccatt cttggacgtc ttgttcagta acagttgaaa gcttgttcag caattcaatc 3699721 tgaaagcttc cagggccttt gtcagccgtc tgctgtgcgg caagctgagc ggcgacccca 3699781 tacgaagaaa tggccgcaat agcagcaaac aatggatttt cttccacagc gcaaaacgca 3699841 ccgacgacgg aagtcagcag gcaaccggcg cctgtcactt ttgtcagcag cttgtggccg 3699901 ttatgaaggg tgtatacatg tgacgtgtcg gctatgacat caacttcacc agttatcgca 3699961 atgaccgtgt ttagcttttg tgccgcctgc tgagccagcc ggatgatgtc gcctccacct 3700021 tcacccgcat caacaccttt gatcagccaa tcggtcacgc cgacggtatg ggcaatttcc 3700081 gccgcatttc ctctgattgc agcaaggcgc acctcacgaa tgatgtcacg tgccgattca 3700141 gtgcggaacg gtgttgctcc ggcaccgaca ggatcaagaa tgacgggaac gccatgttca 3700201 ttagctgatt ttcccgcgat gatcatcgct tcgactgact ccttgctcag tgttccgata 3700261 tttaaaacga gtgcacccgc aattttcgcc atatcggcga cctcttcttt tgcgtacgcc 3700321 ataacgggcg atgcgccgag cgcgagcagg ccgtttgctg tgaaattcgt tacgacattg 3700381 ttggttatgc tatgcaccag tgggctatgc cggcggacag ccgtaagaca ttttgctgct 3700441 gattgtgcat ccatatttgc atcatccttt actatctttt ttcgggtccc ataaatacga 3700501 tttcgtatgt tcgagccaag ctctggcggc aaacgacaag tacctgtcct ttctccaaat 3700561 aatggcgagg tgccaaggga tgaccggatc gacaagcgga atgactttca ctttttccgg 3700621 gtcaaggccg cggcagatcc gttccggcaa aagcccgatc ccaaggttgg cggataccat 3700681 ctcactaata aaatcccatt gtgatgtttc ataaatgata tggggccgga acccagcctt 3700741 gatacattcc gtcataattc ggttgtgcag gacaaaatcc tctctgaaga aaataaaagg 3700801 ctcgtccttc aactcacgca gctgacattc tttctcatca gccagccggt gggaagggtg 3700861 aacgacaagc attaaggttt cttttacgat tgtaaacgaa tgaaagatat cttcgtttgc 3700921 gggaaggacc acaacgccga tatcaagaga gccgtccccg acaccttctt ggacttttat 3700981 agaaccgtct tcgactagct gaaaggtgac attcggatag ttttcacgga aatcgccgag 3701041 cactctgggg aaaaaccccg atccgatcat cggcggcagt ccaatccgta cgtgcccttt 3701101 cttgacttcc ataatatcat ttaattctga cgtcaggttt tgaaatgatt taatgatttc 3701161 ctgcgcctgc acatacatgc tatgaccggc atcagtcagt tccacctgcc tgccgtttcg 3701221 gtaaaacagt tcaattccga gctcttcttc taaatttttg atcatttttg atatcgtcgg 3701281 ctgagaaaca taaagggatt gggaagcctt cgtaaaactt tttaaacggg cgacttccaa 3701341 gaaatatgtt aaatggcgga tatccatgcg cttcaccctt tctatagaca aaaggaatac 3701401 ttcttattct taatatatat tttacctata gagagacctt atgtacaata agtatataag 3701461 ggaggcatca atatgaaaaa actgttgcta accgttattc aaatcgctct gttatttata 3701521 tttgctcggc tgattaattg ggtgacagcc cttcttcata taaatattcc cggcagtata 3701581 atagggattg tgattctttt cacattattg cactttaaca ttatcaagct tgaatggatc 3701641 gagcttggtg cagcgtggct tctcggggag ctgcttttat tttttatccc gtctgccgtc 3701701 ggagtgattg aatacggaga cattatgtcg aaatttggtg tcagcattct gcttgttgtc 3701761 atcatcagca cgtttgtcgt gatggtgtct acaggaacgc ttacacaact catcgcaaag 3701821 agaaaggaga aaaagcatac gtgttcatcg gaattgtaag tttgttttta acggttttgg 3701881 tgtatttagg agcaaaaaag gtatatcaac gctttccgcg tgtttatacg tcgccgctat 3701941 tggtgacgcc cgctgtatta gtcggtctgc tgctgctggt gaatgtcccg tacgagtcct 3702001 ataatctcgg cggcggattg ctgaccgata tgctacagcc ggccaccgtg gcattcgcga 3702061 tcccgttata taaatatttc cctgttttaa agaaatacgc agtggaaatt attttgaatg 3702121 tggccgtcgg ttcatgcatc gcgattattt ctaccgctct tattgcgaaa tggcttcacc 3702181 tcggcaccgg cttaattgac agcctcgtcc caagatcagt gacaacgccg atcgcgatga 3702241 acgtatctga aatgatcggc ggtatgcctg ccgtcacagc cgtgtttgtg attttaaccg 3702301 ctttgctcgg cacagtgatc ggcccgatgg tcatccgtta tttccgcatt gataacgaaa 3702361 ttgcgcgggg cgtgctgctt ggcacaagcg cgcacggagc gggaacgtca aaggcatttg 3702421 agctcagctc tgtgtccggc acgatttcca gcgtgtcgat gatcttagct gcgattatga 3702481 cgctttgcgc ggcgccgttt ttgctttcat ttatgtaaaa aactgtcctc tcgagggcag 3702541 ttttttttat gtgcttcccc ttattgaaaa gctggcgaat tccaatataa tgtatttgtg 3702601 gataccaaag gaggcaccct gatgcacaac ttgcaggtga ggcggcatta tgccgcgtta 3702661 aaaggatttt atttgtttgc ttttctcggt acgggcagca taattccctt actcagtatg 3702721 tatttaacga aggaacagca tttaagcgga tcacaggtcg gcttgatcat gtcactgggc 3702781 ccgattgtga tgattttctt tcagccgttt tggggcatgc tgagcgacta tacgcaaaaa 3702841 acgaaaggcc tgctggcggt ttgcacatca atcacaggca tcattggatt agcctatatt 3702901 gcatttgaca gtttccctct gtttattttg attgcggcct gttttgcagc ctttcaaagc 3702961 acgattattc cactttcgga cagcatttca ctaaggtaca cacaagaaac aaacggcaac 3703021 tacggcggaa tccgcctgtt tggttctctc ggcttcggtg tcgcggtgtt tgccatggga 3703081 caggtgacga accagctgta ccccattcac gtgatcttta tctttggctg tgcctttctg 3703141 tgcattgctg ccatattggc ttcacaagtg cccggccagc agaaaacaac aaaggtcaat 3703201 atccgcaaag gattccggga gcttatcagc aacaaaactt tcctcatctt tatgatcatc 3703261 acctttacga catttgctcc aaacttagcg aacaatacgt atttcagtct ttttctggac 3703321 aaaagcggcg cgtcactttc cgctatcggc attttatttt tcatcggtgt catttcagaa 3703381 attccattta tgagattcgc ccaaacattt atagataaaa tggggctgct caacgtcatt 3703441 atgctgtcag gcggagtctc attattcagg tgggcgctct atttcacggc gccttcacta 3703501 tggatcattt atgcgacggt ctttcttcag ggagtggcca tcggtttatt tatcccggcg 3703561 gcgcttcaat atgtgaaaaa gattacccca agacacgttg aagcgacggc gctgaccatg 3703621 tacgccgcca ttggcaacgg gttcggcaac tggttctgca catttgcagg cgggtacatt 3703681 tttgactacg tgtcgatctt cgcagtctac ttgctttttg gcattctgag catagcaggc 3703741 tttggcctga cattatattt aatgaaggct gaaaaaaaca aacatacact tcatcagccg 3703801 gctgttactt ttaaaccata atgactataa tgaacaaaag aaaggatgtg cgttatgaac 3703861 gggcaagagc gaaacagcat ttcgaaaggg ttgcaggttg atattgtatt gaaagcagat 3703921 caaaaaacag gaaaactgac gagagggaca gtgaaggata ttttgacgaa atcaaacttt 3703981 catccgcatg gcattaaagt ccgtcttgaa gatggccgca tcggccgcga ccagcagatc 3704041 gtttctacat aaaaaaaagc tgcccctgaa cagggcagct ttttcattta ttttttctgc 3704101 agaaggacca ctttcaggta gttgccttcc ggaaatgccg aaatcgtttt gaaatcctcc 3704161 ggcagcgtaa attcctcaat gatcgtgtag cgttcatttg tttctttaaa ggcggcatca 3704221 ataaagcctt tgaacttctt catgccaaag gcgctgctgt ttgtagaggc aacaatgaca 3704281 cccttgtcag cagtgatggc gatcgtttcc ttcagcaggt ttttataatc cttggccgcg 3704341 ctgaaggtgc gtttttttgt gcgcgcaaag gaaggcggat ctagaataat cagatcaaag 3704401 cgcaaatcct tttttgcagc atatgaaaaa tagttaaaaa cgtccatcac tttaatgtcg 3704461 tgcgcttcgt aatccagctt gttcacgctg aattgctcga tcgttttggc aagacttcga 3704521 tttgccacgt cgacgcttgt tgttttctcc gctccgccaa gcgccgccgc cacggagaat 3704581 gcacccgtat aagaaaacgt atttaaaacg gttttccctt ttgcatagcg gtctctgatc 3704641 gccttgcgca catgtctctg atccaaaaag atgcccgtca tggcgccttc attcagatcc 3704701 accgcgtatt gaatgccatt ctcttggatg atgatcggga actcgcccct tctccctttc 3704761 acgaagtcat catcttcaac gtattgtcca gccgtgtcga agcgtttctt ctcgtaaatc 3704821 gctttataat caagatccat ctcatccaat gcggaaatca gcatgtcttt aaaggtgtaa 3704881 attcccttgc tgtaccattg aatcagcagg tagccgtcat aatagtcgat ggtgacgccg 3704941 ccgacaccgt caccctcacc gttgaacagg cggaaagctg ttgtatcttg agcctcaaat 3705001 agtttggcgc gcgcttgggc cgcttttgtt aatttgctga gaaaaaatgc ttggtcaatc 3705061 tgttcatgtt tattgcgggt aagcgtccag ccaacccctt tgttttgcag gccgtaatag 3705121 ccccgcgcga gaaactcgcc gccgctctca gacacgatat caacgaggtc tccttctttc 3705181 atgtgccccg cactccctgc gagagcttct ttttcaataa ggggatagcc tttttttatt 3705241 ttggcagcgt gtgctttttt tagggtgagt agcttcatat atgtcgtcct ctttccgttt 3705301 gctttctctt atggtaccac aaaacgccaa gatgtctgca ttgacagaaa ggaaaggttt 3705361 ttctacgata gacaaaaaga gttacgagga ggagcagcat ggcaaaacga attgaccata 3705421 caggcatcat ggtaagagat attaacgcgt ccatcacatt ttatgaagag gtactaggca 3705481 tgaaattgaa ggatcgcatc actcacacga acggtgtaat cgagcttgct tttcttggct 3705541 ttgaagacgg cccggaaaca gaaattgaac tgattcaagg ctacagcagc gagcttcccg 3705601 ctgaaggaaa agtgcaccac attgccctgc tgacggatga catcgcggct gaatatacaa 3705661 aagcggaaaa aatgaacgca aaatttatcg acgaggagat cacaacactt ccaaacggat 3705721 accgttattt ctatatcgaa ggccctgacg gtgagtggat tgagttcttt cagcggtaaa 3705781 aataaagaac gtacattttg tgatgtacgt tcttttttat ctataccaac tgatatacgt 3705841 tgactcatcg caaatcatag cttcccagcc catacgctca accaattcat ggatgttttt 3705901 atctttggct aaaaagacat taatgaatga gtcatataca ctcataaaca caaaatccat 3705961 tttctcatca gttaaaacga gctctgttgc ggcttcatca agaaccgtcc gcaagttggc 3706021 ttcagttatg tccaaaacgc cgcggttttc cacaatcggt tctgcgtaat aaaaccgatt 3706081 ggatccgttc gcacctaata cctttaccaa actcggaata tgaaaatttg aaatatgatc 3706141 ctcactggga taatagaggt ctccatttat gttttcatgt aacacctcag ccaaatcctc 3706201 tctcgcgaac tcgtccctta aagcgcctat cgacgtcatt aaagccagcg ccagctcagc 3706261 atgtgtttga aagccgcaag aagacataac cttcttccag gaaacagcct tgcctattcc 3706321 tcttatttca ttatcgtttg gataaatatg ttcataatca ttttttcttt ttgcattctc 3706381 ccatccttca ggcatttgga taaaaggaga aaagataaga gcagcagatg agtattcaac 3706441 tggtacttgt tgtaagattg gtgattcgtc atctaaccat atataatcta gcatgcgcac 3706501 ctcctttaca tattctaaca ttcctttcgt ttgaaagaga tgatcagccc tatgacaggc 3706561 tgatcatcta tcacatcaca tttttatccc cagattcaac cgcactctct tcccgccatt 3706621 tttgatgatc ccatattctg aaaaacggat agtagatagc acaggtgatc agcagattta 3706681 ccagctgcat aactgcgccc gacacctttc cgcctgtcgc caggtaacct gatatgagcg 3706741 gcggcatcgt ccatggcacc gcgattccgg ccggtcttgc caccagcccg gtgctcatgc 3706801 cgatataagt cgcggtaatc gtgaggagcg gtgcgatgat aaatgggaca ataaggaggg 3706861 gattcatgac aatcggcatg ccgaaaatga tcggctcgtt gatattaaat agcgcagggc 3706921 cgattcctaa tcgtccaagc tgcttcattt gtttgctgcg ggagcgcaca agcatcgtca 3706981 ggacaagcgc cagcgtcgcc ccgcttccgc cgacattgat ccaaatttga aaaaactgag 3707041 tcgtaaaaat actcggcagc gcctcgcctg cttggaaggc gagacggttg gcatccatcg 3707101 cgccgtacca aatcggcgcc atgattccgc caatgatgga agccccgtga atcccgcacg 3707161 accaaagcag catctgcaca aattcagcga tcaggcttcc gccgagactg ccgccaagga 3707221 tggaaagcgg tgtgccaagc aggtctccta cgacattgtg cagactctga aaaggtgtca 3707281 tttcaatcag aagacgcgcc agccatacga gaagcacaat gataaagccg ggaatcagcg 3707341 cgacaaatga tttgcttacc gcaggcggca caccgtctgg cattttgaag acgatatttt 3707401 tttgaataat gtaccgatag atttcggttg aaaacaaggc gatcagcatg gcgacaaata 3707461 agcccttgct gccgagcagc gtgatcggga ttccgccccc taccatgatg gactccgttg 3707521 agccatgcgg tgtaaacggc acctcaaacg gtgttgccag cagaaatgcg gcaattgaaa 3707581 tcgctccggc agaaagggca tcgacaccat agctttctgc cagccgatag gcgatcccaa 3707641 aagcggcaat catcgccata atatcaaacg aagcgttaac aggatatccg agcttatcgg 3707701 cccactcgtt cccaaacaca ctcgccatga aatcagcata ccccggaatc ggcaagctcg 3707761 ttaaaatcaa gaagacagac ccgataataa tcagcggcat ggtcaggata attccgtcac 3707821 gcaaagcgct gagatgccgc tgcccggcaa ttttcccggc gacaggcatt attttttcct 3707881 ccatcacccg agtgaatgtg ctcatcttaa aaaccccctt ttctcattgc tttgtgaaca 3707941 acctccgcaa tgttttcttt atcttatttt gaaaacgctt acaaattcat ttggaaaatt 3708001 tcctcttcat gcggaaaaaa tctgcatttt gctaaacaac cctgcccatg aaaaattttt 3708061 tccttcttac tattaatctc tctttttttc tccgatatat atatcaaaca tcatagaaaa 3708121 aggagatgaa tcatgaaaaa catgtcttgc aaacttgttg tatcagtcac tctgtttttc 3708181 agttttctca ccataggccc tctcgctcat gcgcaaaaca gcagcgagaa agaggttatt 3708241 gtggtttata aaaacaaggc cggaaaggaa accatcctgg acagtgatgc tgatgttgaa 3708301 cagcagtata agcatcttcc cgcggtagcg gtcacagcag accaggagac agtaaaagaa 3708361 ttaaagcagg atcctgatat tttgtatgta gaaaacaacg tatcatttac cgcagcagac 3708421 agcacggatt tcaaagtgct gtcagacggc actgacacct ctgacaactt tgagcaatgg 3708481 aaccttgagc ccattcaggt gaaacaggct tggaaggcag gactgacagg aaaaaatatc 3708541 aaaattgccg tcattgacag cgggatctcc ccccacgatg acctgtcgat tgccggcggg 3708601 tattcagctg tcagttatac ctcttcttac aaagatgata acggccacgg aacacatgtc 3708661 gcagggatta tcggagccaa gcataacggc tacggaattg acggcatcgc accggaagca 3708721 caaatatacg cggttaaagc gcttgatcag aacggctcgg gggatcttca aagtcttctc 3708781 caaggaattg actggtcgat cgcaaacagg atggacatcg tcaatatgag ccttggcacg 3708841 acgtcagaca gcaaaatcct tcatgacgcc gtgaacaaag catatgaaca aggtgttctg 3708901 cttgttgccg caagcggtaa cgacggaaac ggcaagccag tgaattatcc ggcggcatac 3708961 agcagtgtcg ttgcggtttc agcaacaaac gaaaagaatc agcttgcctc cttttcaaca 3709021 actggagatg aagttgaatt ttcagcaccg gggacaaaca tcacaagcac ttacttaaac 3709081 cagtattatg caacgggaag cggaacatcc caagcgacac cgcacgccgc tgccatgttt 3709141 gccttgttaa aacagcgtga tcctgccgag acaaacgtcc agcttcgcga ggaaatgcgg 3709201 aaaaacatcg ttgatcttgg taccgcaggc cgcgatcagc aatttggcta cggcttaatc 3709261 cagtataaag cacaggcaac agattcagcg tacgcggcag cagagcaagc ggtgaaaaaa 3709321 gcggaacaaa caaaagcaca aatcgatatc aacaaagcgc gagaactcat cagccagctg 3709381 ccgaactccg acgccaaaac tgccctgcac aaaagactgg ataaagtaca gtcatacaga 3709441 aatgtaaaag atgcgaaaga caaagtcgca aaggcagaaa aatataaaac acagcaaacc 3709501 gttgacacag cacaaactgc catcaacaag ctgccaaacg gaacagacaa aaagaacctt 3709561 caaaaacgct tagaccaagt aaaacgatac atcgcgtcaa agcaagcgaa agacaaagtt 3709621 gcgaaagcgg aaaaaagcaa aaagaaaaca gatgtggaca gcgcacaatc agcaattggc 3709681 aagctgcctg caagttcaga aaaaacgtcc ctgcagaaac gccttaacaa agtgaagagc 3709741 accaatttga agacggcaca gcaatccgta tctgcggctg aaaagaaatc aactgatgca 3709801 aatgcggcaa aagcacaatc agccgtcaat cagcttcaag caggcaagga caaaacggca 3709861 ttgcaaaaac ggttagacaa agtgaagaaa aaggtggcgg cggctgaagc aaaaaaagtg 3709921 gaaactgcaa aggcaaaagt gaagaaagcg gaaaaagaca aaacaaagaa atcaaagaca 3709981 tccgctcagt ctgcagtgaa tcaattaaaa gcatccaatg aaaaaacaaa gctgcaaaaa 3710041 cggctgaacg ccgtcaaacc gaaaaagtaa ccaaaaacct ttaagatttg cattccaagt 3710101 cttaaaggtt tttttcattc taagaacacc acacacaacc tttttcccat ccattgtaca 3710161 ggcttttcat actattgcta tacagccatg aacagcataa aatgaacgtt attacagtta 3710221 tcaccacata tggcgggatt gtgactgggc aggcaggcaa gacccaatga tgcaaaggga 3710281 gtattaatgc ctaaaaaaca gggcatttta actcttcttt tcgtgttggg ctcataacgg 3710341 cgccttggac aaccccctat tctcatgctc cgtcgtcgac gcgggcattt ttgtcatttt 3710401 cagccggtat ttctcacttt tttcattttg attgtcaact tttcatttga tacgatgaac 3710461 aagccgactt ttcttcagca aaggaggttt taattgcttg cataaagaga ttgcaaaaga 3710521 attactgctg ctcgcaggag gaaaaaacaa tattatcagc atcagccatt gtacgacccg 3710581 tcttcgtttt gatgtaaagg acgagacgaa aattgatata catgccattg agaacctgca 3710641 aggtgtgcag ggcacctttt tccgctatgg gcttttccag attatcttcg gagcaggcgt 3710701 cgtcaacaaa atatataaag aagtcgttca tgtatgggag accgcgcctt ctgaagagcc 3710761 tgtccaccag aaaaaagcca gccggaagct gaaccctgcc gcagcttttg cgaaaacact 3710821 gtccgatatt tttgtgccga ttattccggc aataacagca agcggcctgc tcatggggct 3710881 gatcggcatg attaaggtgt ttcattggtt cgctgccggc agcccatgga ttaaaatgct 3710941 cgacctcgtg tccagcacag cctttatttt actgccgatt ttagtcggct tcagtgctgc 3711001 acggcaattt ggcagcaacc catacctagg ggcagtgatt gcagggcttt tgacgcatcc 3711061 tgatctgctg gacccgtcta tgctcggcag caaaaccccg tcttctttag acatatgggg 3711121 gcttcatatc ccaatgatgg gctatcaggg ttccatgata ccgattcttc tttccgtttt 3711181 tgtcatgagc aaaattgaga agctattaaa atcgattgtg ccgaagtcgc ttgatgtcgt 3711241 gatcattccc tttattacgg tcatggtgac agggtgcctc gcgctgattg tgatgaatcc 3711301 cgccgcgtcc atcatcggcc agatcatgac acaatcgatc gtctatattt atgatcacgc 3711361 cggcattgct gccggagctc ttttcggcgg catctactcc accatcgtcc tatctggatt 3711421 gcatcatagc ttttatgcaa ttgaggcaac gctgcttgct aatccgcatg tcggtgtcaa 3711481 ctttttagtg ccgatatggt cgatggcgaa tgtggcccaa ggcggagcgg ggcttgcggt 3711541 attcctcaaa acgaaacaat caagcctgaa gaaaattgcg ctccccgctt ctctgaccgc 3711601 gtttttaggc attgttgagc cgattgtatt cggggtaaat ctcaaattga tccgtccctt 3711661 tatcggagca gccatcggcg gtgctattgg cggagcatac gtggttgcgg tacaagttgt 3711721 ggcaaattcc tacggactga caggcattcc gatgatttca atcgtgctgc cgtttggcgc 3711781 cgctaatttt gttcattata tgatcggttt cttgatcgca gccgtctctg cttttatagc 3711841 tacattgttt ctcgggttta aagaagagac agaataactg gatttattcg atttcattca 3711901 taaaacgggg gatgaaagga caaaaaagct atgaaaatta aaagaatctt aaatcataat 3711961 gctatcgtcg taaaggatca aaatgaagag aagattctct tgggtgcagg aattgcgttt 3712021 aacaaaaaga agaatgatat tgtcgatccg tcaaaaatag aaaaaacctt tatcagaaaa 3712081 gatacacctg actataagca gttcgaagag attttagaaa cattgcctga agaccacatt 3712141 cagatttctg agcaaattat ctctcatgcc gaaaaagagc tgaacatcaa aatcaacgag 3712201 cgcattcatg tcgctttttc agaccatctt tcttttgcaa ttgaacgcct gagcaatggg 3712261 atggttatca aaaatccgct gctgaatgaa atcaaagtcc tttatccaaa ggagttccag 3712321 atcggcttat gggccagagc actgattaaa gataaactgg ggattcacat tcctgatgat 3712381 gaaatcggca atatcgccat gcatatccac acagcaagaa acaatgccgg cgatatgaca 3712441 caaacgcttg atattacaac aatgatccgt gatattatcg agattatcga aattcaactg 3712501 tctattaata tcgttgaaga taccatctct tatgaaaggc tcgtgaccca tctccgcttt 3712561 gccattcagc atatcaaagc aggcgaatcc atttacgagc tggacgcaga aatgattgac 3712621 atcattaaag agaagtttaa ggatgccttc ctgtgtgccc taagcatcgg cacctttgtg 3712681 aagaaggaat acggctttga gtttcctgaa aaagaattgt gctacatcgc catgcatatt 3712741 cagcggttct accaacggtc agtcgcacgc tgagacaaac aaaaaacgct tttgatcatc 3712801 tcaaaagcgt ttttttatct gatttattgg ttgatcgccg gattcccaat cgtattccac 3712861 ttcgtatagg acatgtaatg gaaatactca tcgcgatacg gatgttttgt attggagttc 3712921 caaggctttt ctccgccgca gaagtgcacg attgccgggt tttctcttgt ttcattatat 3712981 tgcttccgcc ctaacagagt cgatggggtt ttcagcttta acatgatata ggtttgagcg 3713041 ttccagcgcg gatgaagttc ataccactga tcatacaaga tcgcattcag tgcatcttgg 3713101 tcatgcagca caagaaagtc ttcgtctggg tgttcattga taaagttgat gactttttct 3713161 gtgatgtttt gctttctcca agactcaaaa tcaataatca tgatacctga gttaaaatac 3713221 ttccctgtat cagtgacgtt catttctttc aggcgttcat gctgccccgc atcctcaaca 3713281 gcggctacgg tgtatggcgc aatgtctaag tcccatagct tagaaatatc ctctaggaca 3713341 agcgcatcac aatcgatgta aatcattcgt ttgatgcttt catccttaat taagtcggga 3713401 atcgaaatgc ggtaatacgc ggcttttgta atatggctgc tctcaaccgc atgttcatac 3713461 atgttggtat ccacttctaa aaactcaatc ggcactccga atttcaaagt ggtttcttcc 3713521 agtctttttt tgttatcagg cttaattccg ccatcaatga cgtataattt tacctctctc 3713581 tcctgatcca tgttagtcaa taaagaaacg aacatcccac ctaaatgacg agcataatta 3713641 tcatctgcgc atgatacgat atgcatgatt tcatctttcc tcaatggtat tcatctccct 3713701 ttttgttgta caagttacat accctttttc aaaaaaataa acacgttctc cgacattttt 3713761 ttaaacagaa tgtgtgatac aacaaaaaag gtgtcatttt ttgaagatgc gataaagcca 3713821 ataaagaatg aaaaagcttg cgattgtgat ggcttcagcc gagacgatat accacggcca 3713881 tggcccgaga acatctaaga gagaggaacc gcccggtttt ttcgtcaaat acatataatt 3713941 cgcgccaagc cagcgatcaa tcagaaaaat acagacgccg tacacattaa caagcaggac 3714001 tgtcacccat aacgagcgct ggcccattct gtaggtgcca atcacagcca tcagcagaca 3714061 ggataaaaac acagacccgt gagaaataaa aaagaggata tatcggatat gcggaaatga 3714121 aaacataccg aggtcaggag tggcaagagc ctgaatcgaa ctgccgatgc cgacaaaaaa 3714181 caaaaacaca aacagctttc tgctttttgt cactaacata atagctgaca aatacaccga 3714241 caggtcacta agctggagag gcaatgaagt gcgcaccgac cacctgtccg tggcgaccat 3714301 ccatatttga tagccgattt gcgaaccaag caaaagaaac acaaacagag aacgcaaaaa 3714361 ccggctggcc ctcggctgct tgacctcatc ttggaacaaa aacaacagaa tggccaaaag 3714421 ggagataatc gctaacgtca ctacatgctc tgtcgaaaac agatgaaacg gatcatgctt 3714481 atagtcggat tgaacatatt tttgcaaaac tgcacccccg ttttcgggtt tttgtttatt 3714541 ttggcgttgt ttgggctttt tttattcaac cgatatatgg gcttgaagtt cacaccagac 3714601 tctgttaaaa ttcgtttcat agctaatgat tctgataatt taaggcaggc ctaaaaaatg 3714661 gaacgttcac atcaacatca gcagcttcgg aaggaagaac acgatacact ttctaagctc 3714721 aaacaaatgc ccgtcgagtc actcaacctg gaagccattt cgatcgctac gaatctgtat 3714781 cggtctgcac aaaggctccg tgtcaaaatg gagactgagg ttctttctac ctataacctt 3714841 tcttggaccg ctttctccat tctttatgat ctatgggtat ggggagcgct cgaaacgaga 3714901 aaaatcgctg agctgtcagg gatatctaca gctacagcaa gcaacgtgat caaaacgctc 3714961 gaaaaaaaga gtttttgccg taaaagcatc gacacaagag atcggcgact cgtgtttgtc 3715021 tcaatcaccg attccggcaa acaagcgatc gaagaactct acccggagtt tcacaaaggg 3715081 gaaacagagc tcattgcggg aatgacgaag gacgaacaga aaatattgac agggctgctt 3715141 agaaaggtag ctgacaatct tcatacaaca taagctttga cgggaatcca gtagcggttt 3715201 gtctccctgt ttcagagagc cggcggtagg tgcgagccgg cgcacaggca aacgtgaatt 3715261 acctccccaa gctttctttg tgaaccttag tagcaaagaa cgggaaaccg ttattcgaat 3715321 gagcggaaga caatgtcttc aaccagggtg gtaccgcgtg cattgagcca cgtcccttat 3715381 tgggatgggc tcttttttgt gtttgtaaaa aaggaggaaa aatgatgaga acatttgagc 3715441 agctcacagc gtcacaacaa aaagaggtag aaagacagct tcagctatac atgacaggcg 3715501 cccacgaagt cataccgccg gaggaattaa aggcaaagct cgtgaaatca atttccacgg 3715561 gcacgccgct taaaattaag ctcggattag atccgtctgc accggatgta catttgggcc 3715621 atacggttgt gttaaataag cttcgccaat ttcaagaaaa cggccacatt gtccagctgt 3715681 taattgggga tttcacagga aaaattggtg atccgaccgg aaaatcggca gccagaaagc 3715741 aactgactga tgaagaagtt cagcacaatg ccaaaaccta ctttgagcaa ttcggaaaag 3715801 tgcttgatcc agaaaaagtc gagcttcact ataactcaaa atggctgaaa acattgaatc 3715861 tagaagatgt cattgaatta gcagggaaaa taacggtagc ccgcctgatg gagcgcgacg 3715921 actttgaaga acgcatcgcc atgcaaaaac caatctcact gcatgaattc ttttacccat 3715981 tgatgcaggg ctatgattct gtcgttctcg aaagtgatat tgaattaggc ggaacggatc 3716041 agcatttcaa tgtcctcatg ggacggcatt tccaagaacg atacaacaaa gaaaaacaag 3716101 tcgtcatcct tatgccgctc ttggaaggct tggatggcgt cgagaaaatg tcgaagtcga 3716161 aacacaacta cattggcatt aacgaacatc caaacgacat gtacggaaaa acgatgtcac 3716221 tgcccgacag cctgatgaaa aagtacatcc acttggcgac agacttagag cttgaagaga 3716281 aaaaacagct cgtaaaagac ttagaaaccg gcgccgttca tccgcgtgat gccaaaatgc 3716341 ttttagccag aacaatcgtc cgaatgtatc acggagagaa agcagcagaa gctgccgaac 3716401 actcgtttaa aacagtcttt caggaaaaca gcctgccgga agatataccg gccgtaaact 3716461 ggaaaggcga aaaaacgata gcgatgattg atctgctcgt caagctaaag ctcctctctt 3716521 cgaagagcga ggcgcgccgc atgattcaaa acggaggtgt acgcatcgac ggagagaaag 3716581 taacagatgt tcacgccaaa gcagagataa gagagaatat gatcatccaa gtcggcaaac 3716641 gcaagttttt aaagctccaa taatctgata ttccgaaacg cttatgaccc ttcattcata 3716701 agcgtttttt tgcaggtata aagcactgtc ttttcaaaaa cgctctccat cttgcaggaa 3716761 actcctttag catcccgaaa tattccccaa ccatacattt aggggaggtt tatttttgat 3716821 gaaaaagctt ttgactgtca tgacgatggc tgttttaact gccggcacac tgctcttgcc 3716881 ggcacagagt gtcacccctg ccgcgcacgc tgtacaaata tcaaatagcg agcgcgagct 3716941 tccattcaaa gcaaaacatg cgtactctac catttctcag ctaagtgaag caatcggccc 3717001 cagaatagcc ggaactgcag ctgaaaaaaa gagtgcccta ttgatcgcct catcaatgag 3717061 aaaattaaag cttgatgtga aggttcaacg attcaacatt cctgaccggc ttgagggtac 3717121 actgtcttca gcaggacgcg atattcttct ccaagcggcg tcgggctcag ctccgactga 3717181 ggaacaaggg ctgacggccc cgctttacaa tgcgggattg ggctatcaaa aggactttac 3717241 cgctgacgcc aagggcaaaa tcgccttgat ttccagagga gacctgactt attacgagaa 3717301 agccaaaaat gccgaagccg ccggagcgaa agctgtcatc atttataaca acaaagaaag 3717361 cctcgtgcct atgacgccaa acctgtcggg aaataaagtc ggcattccgg tcgtcggcat 3717421 taagaaagaa gacggcgaag cacttaccca gcaaaaagaa gccaccttaa aactaaaagc 3717481 attcacaaac caaacctccc agaatatcat cggaatcaaa aaaccaaaga acatcaaaca 3717541 tccagacatt gtgtacgtga ccgcccatta cgacagtgtt cctttttcgc ccggagcaaa 3717601 tgacaacggc tcaggtacct ctgttatgct ggagatggcg cgtgtcttaa aaagcgttcc 3717661 atctgataaa gaaatccgct ttatcgcttt cggcgccgaa gagctcggcc tgctcggctc 3717721 ctctcactat gtagatcatc tatcggaaaa agagctgaaa cgaagcgaag tgaacttcaa 3717781 cttagatatg gtaggcacaa gctgggaaaa agcgtctgag ctgtatgtca acacattgga 3717841 tggccaatct aactatgttt gggaatccag ccgtacggct gctgaaaaaa ttgggtttga 3717901 cagcctgtct ctgacacagg gaggatcatc tgatcatgtg ccattccacg aagccggcat 3717961 tgattccgct aactttattt ggggagaccc ggaaacagaa gaagttgagc cgtggtatca 3718021 tacccctgaa gactcgatcg aacatatcag caaagaacgc ctccagcaag caggcgatct 3718081 tgtgacagcc gctgtctatg aggctgtgaa aaaagagaag aaaccgaaaa ccattaagaa 3718141 acaaatgaag gcgaaagcat ctgacatttt tgaagatatc aaataaaaaa agacggcact 3718201 tgggtgccgt cttttttaat ccacttcttt cttaatcccc agcattttct catctaggta 3718261 atgggcaatc tccgcggctt ctttcagctc atctgttaat tgcttaggaa cgtcattgtt 3718321 caatttataa taaattttat gttcaaggct cgcccagaaa tccatcgcga ttgtccggat 3718381 ttgaatttct gctttgacgt attccacacg gttcgttaaa ttcacaggca tctcaatgat 3718441 taaatgcagg cttcgatagc cattcggttt gggtgtctgg atataatcct ttacctttac 3718501 gattctcaaa tcttcatgct gcttcaacac attcacgaca ttataaatgt cagaaataaa 3718561 ggaacagatg atgcgcacgc cggcaatgtc gtgaatatgc tccttcattt ccttcgtcgt 3718621 aatctcacag ccctttctca ttaacttatt cacgatgctt tcaaagcttt ttacacggga 3718681 ttttgtatgt tcaatcgggt tgtgtccgtg aatgaggtta tattcctggc tgataattga 3718741 gaactttgta tcgagcgcat ctagcgcaaa tttataaact aataactcat ttttccaatc 3718801 ttccattact gtttttaaat cgtccatatg tgttacagat aaatccatgt tcgtcatctc 3718861 ctttaacgga actttatccg ctgtccatgt actagacgtc cctgtctgct gcaaggttct 3718921 atgaattttt ttacaaaatg cggtcgattg taacaaaaaa agaccgcatg aaacgagcgg 3718981 tcttttttat tatcggaaat agctgatcaa taatccgatc gagagcagga atccgaaaaa 3719041 tgtatttgtt tgggctgttg atttcattgc gacaatcata ttcatcggca tttcgttctg 3719101 gacgaagccc ttcactgcct gaaccggctt aggcacgctc aaaaagacga caaacagcca 3719161 tgggcttgcg gcaccggtaa taaccaagcc gacaacccag atataagcga cggcaaacga 3719221 cgcagctaac agagtaacag ctcccttatg ccccatcaaa atcgccaatg ttttgcgtcc 3719281 gccttttttg tcctcttcaa tatcacgaat gttgttcgac aggttaatcg cgccgacaag 3719341 aatcgcaatc gggatggaaa tcaaaatgct ctgcatattg atcttatctg tctgaatgaa 3719401 aaacgaaatc agcacaaaca ccgaacccat gcaaatgcct gagaataatt caccgaacgg 3719461 cgtgtacgca atcggcagcg gcccgcctgt atacaggtag ccgatcgcca tgccgacaag 3719521 gccgatcagc gcaagccacc agctgctgct ggcacaaata tagacaccga gcaaaatggc 3719581 aatcccgtat gaggcaagag ctaattgcaa aatcgtttta ggcttcattc cgtggcgtac 3719641 aatggcccct ccgattccga ctgattctgc tgtatctaat ccgcgtttaa aatcatagta 3719701 ttcattaaat aagttcgtcg cgatctggat ccataggcaa gaaaacagca tagccaaaaa 3719761 cagcagcaga tcaaccttca cataaaacat cgccaaaacg gttccgagca gcacaggcac 3719821 aaacgatgcg gttaacgtat gaggacgggt taactgccaa aggatctgcc ccatgctttc 3719881 tttttgcggc gctgtctgac cctcaccctt atttgtttgg ttcatcttcc tcttcctttc 3719941 tattaaaagg cttacttttt ttcagccggc agcttaataa aaaactcctt ttgcttcctt 3720001 atctatcata atgacttctc ccttatttca caagataccg caagaaggcg ttttctttct 3720061 tattatacgc ttctcgccct gatttcatta ggtttctgct ttcacttgaa cgaacaggta 3720121 cagaaaaatt tttttaagta cattacactt tttaaaagtt aaaaagatct tttgactcca 3720181 ggtatctttt cctttattat gaatcagctc gaaacattcc attcttgccc ttgcaggtat 3720241 aaagattcat tttcaaaaac atacgccgat atattaattt gagggagatt agggaaaaaa 3720301 tgaaactttt tgagcatctg atcgtcaaat aatcatgtga ttgtcgaaaa aacgggaagg 3720361 gaatttttga tatgctgcaa ttaatgaaac agctgtatga aaaacccgct gtcaagtgga 3720421 catgtcatac aggcttttat ttgatgatac tgcttgtttt gttttttatg tatggttttc 3720481 acaccgcgaa taccggttca tatatttata acgatttcta attggagaga gaataactat 3720541 gaaactttta catgctattc aaacacatgc ggaaacttat ccgcaaaccg atgccttccg 3720601 ctctcaaggc cagtcgctca cgtatcagga attatgggag cagtctgacc gcgcggctgc 3720661 cgcgatccaa aaacgcattt ctggggaaaa gaaatctcct atccttgtgt acggccacat 3720721 ggagccgcac atgatcgttt ccttcttggg aagtgtcaaa gcgggacatc cttatattcc 3720781 ggttgacctg tctattccgt ccgaacggat tgcgaaaatt atcgaaagct ctggagcaga 3720841 attgctgatc catgcagcag gactctcaat tgatgcagtc ggccagcaga ttcagacagt 3720901 ttctgcggaa gaactgctgg aaaacgaagg cggctctgtc agccaagatc aatgggtcaa 3720961 agaacacgaa acgttttata tcatttacac ttccgggagc acaggaaatc cgaaaggcgt 3721021 gcagatttcc gctgcgaacc ttcaaagctt cacagactgg atttgtgcag actttccagt 3721081 cagcggagga aaaatatttt taaaccaagc gccgttctca tttgatttgt ctgtcatgga 3721141 cctatatccg tgccttcaat caggcgggac tttacattgc gtgacaaagg atgctgtgaa 3721201 taagccgaaa gtcttatttg aagagctgaa gaagtccggg ctgaatgtgt ggacatcaac 3721261 accttccttt gtgcaaatgt gcctgatgga tccgggtttt tcacaggatc tgctgcctca 3721321 tgcggacaca tttatgtttt gcggagaggt tcttccggtt tctgtggcca aagcgctgct 3721381 tgagcgtttt ccgaaagcga agatttttaa tacgtacggc ccgactgaag cgacagtggc 3721441 tgtcacatcg gttgaaatta cgaatgacgt catcagccgc agcgaatcgc ttccagtggg 3721501 cttcgccaaa ccagatatga acattttcat tatggatgaa gagggacagc cgcttcctga 3721561 gggagaaaaa ggagaaatcg tcattgcagg gccgagtgta agccgaggct accttggtga 3721621 gccagagctg acggaaaaag cgtttttctc tcatgaaggc cagtgggcat accgaactgg 3721681 cgatgccggc tttattcaag acggtcagat tttctgccaa ggacgtttgg attttcagat 3721741 taaacttcac ggctatcgaa tggagctgga ggaaatcgag ttccatgtca gacagtcaca 3721801 gtacgttcgt tctgctgtcg tgattcctta tcagccaaac ggaacagttg agtatctgat 3721861 cgctgctatt gtgcctgagg agcatgagtt cgagaaggaa ttccagctga caagcgctat 3721921 taaaaaagag cttgccgctt ctcttccggc atatatgatc ccgagaaaat ttatctatca 3721981 ggatcacatt caaatgacgg ctaacggcaa aattgaccga aaacgcattg gcgaagaggt 3722041 tcttgtatga cgccttacag ctcgttttta ttctttatac tgcttggcat tcttcttctg 3722101 ccgacgatca ttctcggctt aaacggaaaa agatttcaag catacaacat gttcatatct 3722161 atcattatat tggctttaat tttttcgcac gacttacacg gggtcatcgc gctgtgcctg 3722221 tttacaatat ggcaggtgct cctgatcagc ggctatctgg cataccggca gaaagcgaac 3722281 agcggctttg tcttttgcgg agctgttatc gcgtctattc tgcctttatt tctgtcaaaa 3722341 atatggccgt ttctttcaca cccgcagccg catcatccgc cgcataacct gatcagcttt 3722401 ttagggattt catatttaac ctttaaaggc gttcagctga ttatggaagc aagagacgga 3722461 ctgctgaaag aacagctgcc attgcaccgt ctgctgtatt tcatcctgtt tttcccgacg 3722521 atttcctccg gcccgatcga cagataccgc cggttcgtca aggatgaaca gaaggcttgg 3722581 acgaaagaag aatacgccga cctgctgtat acgggaatcc ataaaatctt catcggtttc 3722641 ctgtataaat ttattatcgg ctacgcgatc aatacgtact tcatcatgaa tcttcccgca 3722701 atcacgcaca ataagattct tgggaacctg ctgtacatgt acggctacag catgtattta 3722761 ttctttgatt tcgccggcta cacgatgttt gccgtcgggg tcagctacat tatgggcatt 3722821 aaatcaccag aaaactttaa taaaccgttt atcagtaaaa atattaaaga tttctggaat 3722881 cgctggcata tgtctctgtc attttggttc agagattatg tgtttatgag attcgtattt 3722941 tggatgacta agaaaaagtg gatcaaaaac cgtatggccg tctcaaacat cgggtatttc 3723001 ctgctgttta tgctgatggg ggtttggcac gggctcgcgc cgcaatatat catttacggc 3723061 ctctatcacg ccgttctgat gacgtgttac aactttttcg agaagtggaa taagaaatat 3723121 aaatggctgc cgtccaaccg ctggacaacc attctcgcta ttgtgatcac attccatttc 3723181 gtttgcttcg ggttttatat tttctcagga aaaccatttc atcaccacca ttaaaggaga 3723241 ttagaaagct atggatttta aacaagaggt attagacgtt ttagcagagg tttgccagga 3723301 tgacatcgta aaggaaaatc ctgatattga aatttttgaa gaaggtttgc ttgattcttt 3723361 tggaacagta gaattgctgc ttgcgattga aaaccgtttt gatattttag tgccgatcac 3723421 tgaatttgac cgggacgttt ggaatacacc taacaacatt gtaaatcagc tgtctgagtt 3723481 gaaataatga aaaagcgttt tttcggtcca attattttgg cgtttattct attcgcaggc 3723541 gccatcgcaa ttccatcttc atggctgaca ggcttcatca ccgataagcg tgtgaaagag 3723601 tcagcaacag ccttgaatcc gagtatgttt caagggctat atttacaaga tcagatgctc 3723661 aaagatccga catatcttcc gatttacggg tcttctgagc tttctcggct ggacgagttc 3723721 cacccatcta attattttca ggtaaacaat gagggattca cgccatacct tgtcggcaaa 3723781 ggcggatccc agtcattgat tcattcttta aacttcgctg cccacatgga tcagctgaag 3723841 ggcaaaaaaa tcgtattcat cgtgtctccg caatggttta ttaagcgcgg gtctgatgaa 3723901 cagcatttcg cgccgaacta ttctgcgctg caagggcttg atttggcatt taacgatcag 3723961 atcgatcctg aaattaaaaa gaaaatgatg aaacgcatgc ttcgctttaa ggctgtgcaa 3724021 aacgatgcca ttctttctga gctgtacaaa gcaatggtaa acggtcagac gtggaaagtg 3724081 aacgcgctga agccggcggc gaaagtgtat tacagcatgc tggaaaagaa agatctgtat 3724141 tattcaacga cagaatcatc cgggccaaag cgctatatct cgcagtcagt aaaggataag 3724201 tcatggtctg aattgaataa actagcggat caatcgggca aacgccactc cggttctaac 3724261 gattttcaca tcgacaaccc tgtctataaa aagctgaagc cgaaagtgcc taagctgaaa 3724321 gggaaaaaca aaggaagatc gtatgcggtg tcaccggaat atggcgactt tgaaatgatg 3724381 ctcgatatcc tgaaggatgc gggcgcagag cctatgtttg tcaccattcc tgttaacggg 3724441 aaatggtacg attacacggg cttcccgaaa aaaggacgca ctgactatta caaaaaggta 3724501 aataaacaaa tcagagcgaa gggcttccag gttgctgatt tctcagggca tgaatatgac 3724561 ccgtatttca tgaaagacac cattcacatc ggctggaaag gctgggtgta tgtcgataaa 3724621 gcaattgacg aattttataa aaccggaaaa gtcacttcat cctgagcatc tcataggacg 3724681 cggctgcata tttcctgcta agatttgtaa tagtaaagga atcacagcca acttaattaa 3724741 gaggtgttac atccaatgaa gatgacaaat aatacggttt taatcacagg gggttctgct 3724801 ggcatcgggc ttgaactggc caagcgcctg ctggaacttg gcaatgaagt tatcatttgc 3724861 ggacgcagcg aagcacgtct tgcagaagcg aagcagcagc tcccaaacat ccatacaaag 3724921 caatgtgatg ttgcagaccg ttcgcagcgg gaagcattgt atgaatgggc tttaaaggaa 3724981 tatccgaact tgaatgttct cgtcaacaac gccggcattc aaaaggaaat tgactttaaa 3725041 aaagggacag aggagctttt tgtggacggt gatgaaattg aacttaattt ccaagcgcct 3725101 gtccatttat ccgccctttt cacacctcat ttgatgaagc agcccgaggc ggcaatcgtt 3725161 caggtcacat ccgggcttgc gtttaacccg ttagctgttt atccggtgta ctgcgcaaca 3725221 aaagcggcac ttcactcgtt ctcgcttacg ctcagacacc agctccgcga cacgagcgtg 3725281 gaagtgattg aaatggcacc gcctatggtg gacacgggct taaaccaaaa atcacgcgat 3725341 aaacaaggcc tgacgtaccg gggcatttca tctgaagaat atgttcaata tttcttggac 3725401 ggcttgaagg aaggcaaaca ggagattaca aatgaacgtg ttgaaggtct tcgggatgcc 3725461 actcgcgccg attatgacag gttattcgag caaatgaaca cgcaggagaa ttaatttctc 3725521 ctgctttttt catatgaatt tcttacaaat ttgagcaaac ctattgcgat tatttgttga 3725581 aggtatacaa tagaatataa ttattttcaa ataagtttga taatataaac aatttaacag 3725641 cagggagatt gaccatgact aaacaaacaa ttcgcgttga attgacatca acaaaaaaac 3725701 cgaaaccaga cccaaatcag ctttcgttcg gaagagtgtt tacagaccac atgtttgtaa 3725761 tggactatgc cgcagataaa ggttggtacg atccaagaat cattccttat caacccttat 3725821 caatggatcc ggctgcaatg gtctatcact acggccaaac cgtgtttgaa gggttaaagg 3725881 cttacgtgtc agaggatgac catgttctgc ttttcagacc ggaaaaaaat atggaacgcc 3725941 tgaatcaatc aaacgaccgc ctctgcatcc cgcaaattga tgaagaacag gttcttgaag 3726001 gcttaaagca gcttgtcgca attgataaag actggattcc aaatgcggag ggcacgtccc 3726061 tttacatccg tccgttcatc atcgcaaccg agcctttcct tggtgttgcg gcatctcata 3726121 cgtataagct cttgatcatt ctttctccgg tcggctctta ttacaaagaa ggcattaagc 3726181 cggtcaaaat cgctgttgaa agtgaatttg tccgtgcggt aaaaggcgga acaggaaatg 3726241 ccaaaaccgc aggaaactat gcttcaagct taaaagcgca gcaggtagcc gaagagaaag 3726301 gattttctca agtactctgg ctggacggca ttgagaagaa atacatcgaa gaagtcggaa 3726361 gcatgaacat cttcttcaaa atcaacggtg aaatcgtaac accgatgctg aacgggagca 3726421 tcctggaagg cattacgcgc aattcagtca tcgccttgct taagcattgg ggccttcaag 3726481 tttcagaacg aaaaattgcg atcgatgagg tcatccaagc ccataaagac ggcatcctgg 3726541 aagaagcctt cggaacaggt acagcagctg ttatttcccc agtcggcgag ctgatctggc 3726601 aggatgaaac actttcgatc aacaacggtg aaacaggaga aatcgcaaaa aaactatatg 3726661 acacgattac aggcattcaa aaaggcgctg tcgcagacga attcggatgg acgaccgaag 3726721 tcgcagcgct gactgaaagc aagtaagaaa aaagccggcc cattacaggc cggctttttt 3726781 tacgcttcaa ttttgttgaa aaactgcggc agatacgctt tgtgcgcctc tagcatttcg 3726841 tctaaaatct gtttggccac agtatcggac gggacaagcg ggttaatcgt catggcaagg 3726901 agcgcagttt gatagtcacc tgtaactgcc gcttctgccg cgacacgttc aaaggatttg 3726961 atttgctgga caaggccgcg gacagacacc ggcaagtcgc cgacagcaat tggcttaggg 3727021 ccggttttcg tcatcacaca gttcacttca actgcggaat cgtctggaat actcgctatt 3727081 gcaccattat tgatcgtgtt caccggctga atgtcatgtt tatcattata aatggagctg 3727141 attaagttac atgctgcatc actgtagtaa gctccgcccc gtttttccag ctgcggcggt 3727201 ttgatcgcaa ggtttggatc tttataaagc tcgaacagct ctttttcgac cttctgtacg 3727261 acttcagcgc gggtgccctc cgtttgtgat gcttccagtt cgtgctccag catctctttt 3727321 gttttaaaat agtaacggtg atagccgcaa gggatgacat tgagcgcttt taagaaatcc 3727381 ggttcccatt cggcgcctga gatatttttc atcgtcatcg cgtttttcgg gtcgcccatc 3727441 gcctcgatga cttgctcctt cacacttacg ccgtccaaga aaacatccag cccgaatacc 3727501 atatggttca gtccggcaaa ttggacttct acgcggtcca catctacatc aagcgctttg 3727561 gctacgccca ttttgatgcc gattggaaca ttgcaaagac cgacgacttt cttcaggttg 3727621 gagtagcgaa gcaaggcttc tgttaccatg ccggcagggt ttgtgaagtt aacaagccaa 3727681 gcgttcgggc aaagctcttc tatgtccttt gcgatctcaa ggatgaccgg aattgtgcgc 3727741 aatcctttaa acagacctcc cgggccgttt gtttcctggc ctatcactcc gtattttagc 3727801 ggaatgcgct catcctttgc tcttgcctgc aaaagtccga cgcggaattg ggtcgtgaca 3727861 aagtctgcgt ctttcagcgc ctttctccgg tcgagcgtaa gatgaatgtc aatcgggacg 3727921 ccagcttttt caaccatccg tttggcgagt gtgccgacaa tattcagctt ttcttcgccc 3727981 tcggggatat cgacaagcca taattcacgg acaggcagct catcataccg tttaatgaac 3728041 ccctccacta gctcgggcgt atagcttgaa cctccgccaa tcgttacaat cttcaatcct 3728101 tttgtcatat gcttgctccc ctttgctcgg tgattttttc atataactca atgatctctg 3728161 cagccatatc cttcactgtc attgcattca ttaaatgatc ctgtgcatga accatcagaa 3728221 gcgtcatttc cgtcttttct ccgcccgctt cattttggat cagctctgtc tgataatgat 3728281 gggcttttga caattcttca gcagcgtctt gaagcttttt ccgcgcttct tctgcgtcac 3728341 cgcttttcgc agcggcaatg gcctccattg cggagctcct accgtttcct ccgtgaagga 3728401 tgatttgaaa aatgatttgt tccatttcct cattcacgcg attcacttcc tttctctaca 3728461 gagccgcttc tttgtcatct gttgctgcag gcgtttggac cagctccaga tcgttttctt 3728521 ctttcagctt ctgcttatcc cacattctga agaatggata gtagacaaca aaggacacgg 3728581 caatattaat ggcttgcatg accgcgcctg agacttttcc tcctgtcgcc aagtagcctg 3728641 aaaagatcgg cggcatggtc cacggcactg cgatacccgc cggtttggcg acaaggccgg 3728701 tgctcattcc gatgtacgtg agtgtcactg tgacaagcgg cgtgatgata aacggaagta 3728761 agagcattgg gttcatgacg atcggcattc cgaatataat cggttcgtta atattgaaga 3728821 tggccgggcc gaccgcaagc ttcccgagct gcttcatttg tttgcttcgg gcgcgcagga 3728881 acatcgtgac aaccagtgcc aatgtggcgc cgcttccgcc aatattgacc cagatatcga 3728941 aaaattgctg ggtgaaaatc ttaggaagct cctcaccggc ttggaatgcg atccggttgg 3729001 catccattgc gccgtaccaa atcggtgcca tgacgccgcc aacaatgttt gcaccgtgaa 3729061 ggccgcaggc ccataaaagc attttgacgg cttcggcgac aaggcttcct ccaaggcttc 3729121 ctcccagaat ggaaagcgga gtccccaata aaacgcttac aatattatga aggctttcaa 3729181 acggtgtcgc ttcaacaatc agccgggctg cccaaattag gaagatgacg gcaaagccgg 3729241 ggattaacgc gacaaatgac ttgcttaccg ccggcgggac accgtccggc attttgaaga 3729301 ctaaattgcg ctggataata aggcggtaaa tctctgtgga caccattgcg ataatcatgg 3729361 cgacaaataa gcctttgctt cccatgagcg aaagcggaat cccgccgcca accatgattt 3729421 ctttcgtcgc gccatccggc ataaacggca cttgataagg tgttgctaat aaaaatgccg 3729481 caagggaaat ggctccggcc gacaaggcat caacaccgta tttctcggcg agccggtagg 3729541 caatgccgaa cgcggcgaca agacccataa tttcaaaggt cgcgtcgact gggtaggcca 3729601 gtttttcaga ccaggagctg ccaaacgttt ttgccataaa ctcagcgtat cccgggatcg 3729661 ggaggttgcc aatgatgagg aaaaaggaac cgatgataat caggggcatc gtgaggatga 3729721 taccatcacg cagcgcctgc aaatgacgct gtcccgcaat tcttcccgct ataggcatga 3729781 ccttttcttc taagatctga ttgactttat tcacatagcc cgcccctctc tatgacacat 3729841 gtccaagctg ttcagctgat ttcagcactt ccgccccatt gcacgttcca taatggacgg 3729901 tattaatgac gtctaccgga accccctttg actctcctaa ttttttgagc tgcggaagca 3729961 tgtaacggac ttgcggaccg agaagcaata catccgcttt atcgatatga ttttgtacag 3730021 aatcgcctga aactgcccaa atggtatagt cttttccctg ttcctgcgca cttttttcca 3730081 tcttgctcac cagtaagcta gtagacatgc ctgctgcaca aacgagtaat atattcatgt 3730141 aaaagacccc ctagagtttg atcaattttg taatgtcctg ctgttgctat catcatatta 3730201 tgaaatcgct ttcataaaca ctcagggttt ttccgcaggc aacggaaaaa aggtatatac 3730261 aggctgtcag ctcagcattt tttggtcaaa cacatccgaa agctcttgat atgaacggca 3730321 tttgatcagc tggttcatcg ccgccgggtc atccaaaatg ctgccaagca gtttatacat 3730381 gctttgtaaa tccgctttgt tctccttttc gacacaaagc agacagacaa attgaactcg 3730441 ctgactctcc caatcgatcg gttttttgag cgtacaaacg gcccaaaacg ttgttttcgt 3730501 ctgcggaaca agcgggtgcg ggatggcaac aagattgcca aaacacgttg gcgacatgtc 3730561 ttctctttca aaaatggaat ctatgatttc ttcatcggca aagccgcatt cgaccacttt 3730621 ctgccctaaa aattgaatca cttcttcttt tgagcgcaga tcctcctgaa aaaaaacgag 3730681 ttcttttttt aggtagcgat tggctttttc cttttcatca ctcagaatag attctatttt 3730741 tgtaaagtca gttccgccta agatggtgtt aaccttcagt actggtacag ggagctcttt 3730801 tttaatcgga atggtgctga tgacaaaatc aattgattcg taggacattt gatcaagact 3730861 ataatactca gccgttccaa gaatatcgag ccgcttgccg aaatgggaac gcagtttttc 3730921 gcgcagaagc tgggcgcttc cggctcccga tgcgcataca atgatacagc gtttcggcgg 3730981 gctttctgtt ttttttcgtt caatcgcggc gccaaagtgg agagccaaat atccaatttc 3731041 gttttcatga atctcaatac ccgtttgttc ctttatcacg attccggcaa tgatcccggc 3731101 ttcaaaagcg agtggataat gttccttgat cgctgccagc atcggatttc gaagattcat 3731161 gccgtatcgg ttgcggctga tcgccggctt catatgcagt gccaagccga ttttcagctc 3731221 tttgtcatgc aggatgccaa gcttcagttc acgatcaaca gctttgatca tggcaagtgt 3731281 cagctgatcg gtttcctctt ctattgaaaa tgtgtcctct ccgcattgtg attgtgtcat 3731341 tcgttttgtg ccaaggagat gcatggtgat gtaggccgtc tcgtctttcg gaaacgtaac 3731401 ggaaagcttt gattccagct cttttacgat ggcttctgca gcctggtact ccttttgatg 3731461 caggatatga tccatatctt tcgggaaaag agaaacatag ttttccgttc tgatccgttt 3731521 acaggcgata gcgatatgga taatgaggtt attcagtccc atgttggaca gagggatgcg 3731581 gtcgtttttc atttttttca agatggcgga acggatgatc tcaatttctt cttttggcaa 3731641 aatatcagcc ttttcattta aaacatctat ctccgtttct ctttcatcaa caatgtactc 3731701 cgccatgcag tacctcatct gcacctcgtc cccgcgcagc ttgaagccgt aattcggacg 3731761 tgtttccatg acgatgcggt aaggcagcag acgtttcttt acttccttta aatccgtttg 3731821 gagtgtagat tttgagataa atagttcttc agcaagttca tcgagcttga gataatggtc 3731881 cgccagcagc agacgtttca taagataggc cattctctcc tccggcaata ccggcaggcc 3731941 ctttttttgc tgaaattcat cttgcagcag tgttctgaat acttgctcgt catcaatgcg 3732001 gagcttgtag ccggagcctc ttacagattg tacaaaggca ccgtggccgc ttagcacacc 3732061 ttgaagttcc tttatatcat tgcggactgt ccgcgtcgtt acgtttaatt gcgcggcaaa 3732121 aaacgaactt gtcaccgggg cttcagccgc catcagcaag cgcagaatat cacgtagtcg 3732181 cccatgaagc atgagaaaaa cctcctaact agtagatgca gggattcagt gaataggcag 3732241 aaaggatgat gaagggatgc gaaatgtata taaattctat aatggagaga atggcaagtc 3732301 aatgaacatc cggaggacta gagggaaaac tgacctataa aaaaacagcc gggatcagcc 3732361 ggctgttcta gatgcggaca tattcttttg tttagacgcc ttgcggtcct tcatgatttt 3732421 tcgaacaatc gggtaaatga ccggcgccca tttgataacg gttttgatca tctttttcaa 3732481 agctccgatt ctcccttctt ttttctcaac cattcccctg attgcctctt ccttaaacat 3732541 gctaacgcga cacgtacctg tttcccgtca cccagaaacg ccatggataa tcgcgtgcct 3732601 ccccgctgtt gtcaatgccg atgcgcgggc cggttgaaat tgcttccggt gtgtacccgc 3732661 tttcgatgta aagcggctgt tccgtgatcc agcgtccgta gtcattcatc gtgacgccaa 3732721 gcgctttcgt cagctttcct ggtccgtttg tccattccct cggactcctg cccggccttc 3732781 tctcctccat taacagctgg ccttcatgcg gctcaatcgc cctgattaat actgcttgcg 3732841 ggacatcctc ttccgccgca acgacattca gcaatgtatg ggtgtgcatc acgtatgtat 3732901 atacccgccc agcttctgca aacatgatct cagtccgctt cgtccggcgg ttgttaaagc 3732961 tgtgggccgc tctgtctcca gcccccatat aggcctctgt ttccacaata tagcctgacg 3733021 ctgtgccttc gtctgtttct tttacaagaa ggcagcccag aagcgatggg gcaagctcaa 3733081 gagcggtttt ttgataaaac gtgatgggca gcggattttt ttctctcgtc acgaatcgac 3733141 ctctcctttt accgattttt gtacattgta ccattcccga agcagatcaa aaaaaacggc 3733201 tgttttaaaa tctttccatt cagggaatat tgttaccgtt caaaaaagga gggccaacca 3733261 ttgaaagatg atcatcaaaa caagcagcac caatcaaatg cccaagggag cgaggaagcg 3733321 ttttctcata agacatccgg gaaaaacgag tcagaggata ccttaacgaa taggcagggg 3733381 catcctgtta ctgacaacca gaatgtgaga accgtcggga atagagggcc tacaacactt 3733441 gagaactatg attttctcga aaagatcagc cacttcgacc gggaacgcat cccagagcgg 3733501 gttgttcatg ccaggggagc aggtgcacat ggatattttg aagcgtacgg aagcttcgga 3733561 gacgaaccga tttcaacata cacaagggcc aagctctttc aggaaaaagg caagaaaaca 3733621 ccggcatttg tccgtttttc aactgtgaat catggaaaac actcgcctga aacattgaga 3733681 gacccgcgcg gttttgctgt aaagctatat acagaagacg gaaactggga tttggtcgga 3733741 aacaacctga aaatcttttt tatccgcgac ccgctgaaat ttccggatct tgtacacgca 3733801 tttcagcctg atccagtgac aaacatccag gatggtgaac gtatcttcga tttcatttct 3733861 caatctcctg aagcgacaca catgatcacc ttcttgtttt cgccttgggg cattccggcc 3733921 aactaccggc aaatgcaggg ttcaggcgta catgcctata aatgggtgaa tgaggagggc 3733981 aaggccgttc tcgtgaaata ccattttgaa ccgaagcagg gcatccgcaa cctgacacag 3734041 aaggaagcag aagagattca agggaaaaac tttaaccatg ccacacagga tctatatgac 3734101 gcgattgaaa atggcgatta tccagagtgg gaagtatatg ctcaaatcat gagcgatgat 3734161 gagcatcctg aactggactt tgatcctctt gatccaacaa aactgtggta taaagacgat 3734221 ttcccatgga aaccgatcgg caaattggtt ctgaacaaaa atccggaaaa ctaccatgcg 3734281 gaagtggagc aagcttcatt tggaacggga gtgcttgtcg acgggcttga tttttcagac 3734341 gacaaattgc tccaggggcg tacgtttgcc tactctgata cgcagcgcta ccgtgtaggc 3734401 gcaaattacc tgcagcttcc gatcaactcg ccgaaaaagc atgtcgccac caaccaggaa 3734461 ggcgggcaaa tgcaatatcg ggtcgataga gcagaaggac aaaacccgca cgtcaactac 3734521 gagccatcca ttatgggcgg gctgaaggaa gcgaagcaag acggaaaaga ccatacgccg 3734581 catgtcgaag gtgatgtaaa gcgtgaagcg attgacagaa caaacaactt cggacaggct 3734641 ggagaaacgt accggagatt tactgaattt gagcggaacg aattgattac gaatttggtg 3734701 aatacgcttt ctacgtgccg aaaagaaatt caggatcaaa tgattgagaa tttcacaaaa 3734761 gctgatcctg actacggaaa acgcgtagca gaagggctaa aaaaggtctc cgaaaacaac 3734821 agcaacgggc cgatcggcac aactgaaacg gaacaggctg caaagcaggc tgaacaggag 3734881 agtcatccgt ctgatccgta ttaacaacag cgaacagggc ttttttagaa gccctgtttt 3734941 tttatttttc tattgaaacg ctttcaataa ttgtgttgta cttggaagga aaggggtgga 3735001 gagatacgat ggaattacag caggacttga ttcctcagaa aaaaacaatc ggcgctttag 3735061 atcacgccgt ttttttatgc atggtatttt gtttctggtt ttcaggctat atttacgttc 3735121 ctgtattcag tctgtatttg gaggatctgc acttttcata tggcgcaatc ggcatcattc 3735181 tcggcagcta cggggtcacg caaatccttc tgcgattccc gctcggcctt ttgtcagaca 3735241 tcctgttttc cttgcgcaag caattgttaa ttgccgggtt cggcttttcc gtcctcagca 3735301 gcctgctttt tctgatgttt gattctttct tcttcgtgct ggccgcccgg cttttcgcgg 3735361 gaatcactgc ttctacgtgg gtgatggcga ccattttata cgcacattat ttcaacaatg 3735421 gcaatgcatc aaaagcaatg ggcatcatgc agttttttac cgtcatgcct cagtttgcca 3735481 gcattgtgtt ctgcgggctc gccgcagccc atttagggag gcaggttcct ttttggatgg 3735541 cgctggcagc ttctgccgca ggtctggtga tctgctgctt tattcaggat ccgtctgctc 3735601 ctcccgcaaa ccgtggcacc attcgtgtca atcagtacat caaagataca ttgcggctgc 3735661 caaagctgaa gcttttcacc atcctgtcta tgacggccca tgccgtatta tttatcacag 3735721 tgtttggttt tacgccgctt tacatgaatc agctcggaat gggcgacgcg gagctgcttt 3735781 gggtgatgag cgcctttttc ctcccacacg cagccgccac attaagcttt gtgtttctgc 3735841 gctttacaag ccgtatcgct tactccgtga tgctcattag tttcgctgtc accggggtct 3735901 gtttgctata tgttcctttt ttagctgcat tgttcacggt ttgcatcaca cacgcctgta 3735961 ttgggctggc gctcggcttc gtttttcctc tgctgctaag ccatgtcgtc gaaatcagtt 3736021 ctgcccgttt aaaaatgtca gtgatggggt tttaccaatc attttatgcg ctaggcatct 3736081 tcctcgggcc ccttcttgcc ggaaaaatcg cacagcttat cgggcttgcg ggagtttttt 3736141 atggagccgg ttctctggca tttgccgcct tttttgtgat gctcgcgcaa aaacgtaaca 3736201 tgatcaatta atagctttca taccgccgga agcgccacac agaaaacacg gccagaagca 3736261 tgatgcacag aatggagaaa gtgagtgacc atccgaaaaa atctgcccgc tctccatgaa 3736321 gaaggatatg ctccgcctgc ttgcaaatct cagccggaag ccacttcgca ccatctggaa 3736381 atagtgaaac agcaaaggaa acggctgctg tgagcccgat cccgcaagcc gcagctgctc 3736441 cgacagaccg gaatatcgta cttccggcaa ggccggcggt cacaataaat atcacccaaa 3736501 gagcgtaaag gccaaggctt gcggcaaagc ggctgaatga tgcgtcctca aacagcagcc 3736561 ggacgtaata gtaagcaagc ccgtatccag ctgcaaacga cataatgccg atcacgcttt 3736621 ggatgagcca tttactcacg atataatggg ctgccgtcac aggccgcgac ataatcagcg 3736681 ctgttacccc ttgatttctt tcattggcta cactgcccat cacgctaaag atgaccagag 3736741 ccatgccaag cgtgttgaat tgagaaagcg tgctgaccat cacttcagac ccggagggca 3736801 tcgtaaaact gattttcatg ccgtcaggaa ggttccctcc atgtgcgatg atttccggca 3736861 tataataaat ggtcagcggc tgtgtcagcc cgacgatcat catcgcaatc ggcagccaaa 3736921 tcagcttgcc gcttttccat ccttccagcc actccttctg caatagcgcc atcatcacct 3736981 tcatgcgtgc accaccttta gatagacgtc ttctagagac tccgttttct gttcaaagcg 3737041 ggtgacggtc aatccctttc ggatacagtc acttaataat gaccggccag cgtgtatatc 3737101 aggcagctcg aaaaccgctt gggacggatt cttatagaca atagctgaga cgtaaggctt 3737161 ctcttcaagc caaccttcca gcttctcttt cactgaaagg gtaaaaacgt tcgtttgctg 3737221 ctgttgtttc agctcctgta actcgccttt ccatgaaatc tcaccgtttt tcataatcac 3737281 cacttgatca cacacctgtt ctgcatcgtg caaaacatgt gtagaaaaca gaacggccat 3737341 atgctttttc agctcccgca tcatgtccag cacctcgaac cgtcctgtcg gatcaagcgc 3737401 agacaccggt tcatccaata tcaaaaactt cggtttatgg agcagtgcct gtgccagacc 3737461 gagtctttgt ttcatgcctc ctgaatagcc cccgatcctt ttgtgcgccg cttcgtgcaa 3737521 accgacaaat tccagcatct cgccgatttt ctcttggcat tttctcttcg aaaggccgga 3737581 cagtctcccc gcaaatgtca aaaattcatt tgcggtcatc cacgaataaa aagcaggata 3737641 ctgcgggagg tacccaatca aacgccgatc cagctttttc tctcctaaca gctttatggt 3737701 tccagaggtt ggcgaaagca gtccggccag catttgcaga gtcgtggttt tgccggctcc 3737761 attaggtcct aatagtgcga cacactcatt ttcattcacg tgaaaactga cattctttac 3737821 agcttcatgg tgcctgtacg atttgcataa tgattcaata gacagcatat cggcttacct 3737881 ttgctttctg ccgacggtga aaaataaaat cggcccgata atattgatac atacgatgat 3737941 tgcagcccac atccactttg gcccgttcgt ccgctcttct tttatacagc tgataagggc 3738001 aaacaccgcc aaagccagct gtaatacaat cagcggcaaa atcatttccc aagaaatatt 3738061 cattgcttga tccccctttt cttccgatcc ggcctaatga caaaaaagta ataacaaatc 3738121 agaggcatcg gtgcttgaat caatccgaca atcccccaaa cccatgccat gtgattacgt 3738181 tttttcgcat caataaataa aaagattccc tgcgccaata cgatgagaca agccgcaacc 3738241 gttatgataa tttctgtttg tgtcatccgc gtttcacctc gcattcgccg agatgccttt 3738301 ttttctcagc cgcaatcaaa atcggcagca ccgcaagcac acaaacctga agcacaataa 3738361 acacagcagg agcttgagtg aaagctaaga ttgcagcact cacaaccatc agcgcgcaga 3738421 atacaaataa aatgatctct tgaagaagtt tttttctgta ttcagctttc atttgtgaca 3738481 gctggtgaag cagttctttt tgattcggta tagagggatt ggctgtttga tcaatttttt 3738541 tccattctga ctttaaatga tcagaaagct tttctttatt catcatccca ctcctttctg 3738601 atttgctgga gccctttatg aactctggac tttacagtgc cttctttgat ttgaagcatc 3738661 accccgattt cagcgtaggt atagccgtag taatgcctta ataaaaccgg tgtgcgcagt 3738721 ttagggtcca gctttgaaaa cagatcgagc gtttcgctcc actctgcccc tttcgccgac 3738781 acgtcccact tgatcttgcg gattgtttcc tccgtaactg tctgattccg tttccattct 3738841 ctctttctct ttttctggtg atcgagatag agccgcgatg caatggagat cagccatgtg 3738901 gagaattttg aacggccctg aaagcttctt aaatggatgt accctttcag aaaggtttcc 3738961 tgaacaagtt cctcgctgag atcggggtga agggaaagct ttaacaagta tttatataag 3739021 aaagaatagt gatagtggaa aagggctgta aacgcctcgt cgtttccctc tttcgcctgc 3739081 tggatcagcc gctgttcttc ttgtgtatcc aatgaccgtg atcccccctt ttttgttttt 3739141 ctgccttatg agacgacacc ggattcaaaa gcgttcatct tttttacaat tcttttcagc 3739201 cattgacaga tcaggcttcc cggccgtttg gctgcatatc cttatttgta aaccccctta 3739261 tagtctgtta agctatgact ttatgtcgat ttcaaaaaaa catccaatat ggaggacgat 3739321 gcattgaaag tagaaaggcg aacgattgaa tatattccga atgaagaaag acatggtaaa 3739381 gcgaaagatt tatttcccgt atggttcggg gctaatatgc atatcaccac gttagtgacc 3739441 ggcacgattc ccgttgcaat gggacttaat ctgttttgga gtgttgccgc tattatttgc 3739501 ggaaccttaa tcggtgccat atttatggct tctcattccg cgcaaggccc tcagctaggc 3739561 atcccgcaaa tgattcaaag ccgtgcccaa ttcggcgtaa tcggagcgat tcttcccctc 3739621 ttcttagtca tgtttatcta ccttggtttc ttcgcaagca gcacgattct ggcggccgga 3739681 accttaagca gctttgttcc catcccggga tcatggagca ttataggctt aagtgccgta 3739741 tgttttttac tcaccatttt cggccatgat ttgattcaca aaatgcaaaa aatcctttct 3739801 tggacctctt ttgctgtatt ttttgctgca acgattctca tttttcaatt gccgattccg 3739861 gcaggcagct ggatacccgg agcgattgat ctgccaattt tcctagtggc agtcagcgca 3739921 gttgcgacgt ggcagcttgc ctacgcgccg tatgttgccg attattcaag atatctgcca 3739981 gttaaaacac cggcttcaaa aacattttgg tacagctatg caggtacatc tgtcagctcc 3740041 atctggatga tgctgctcgg cgcattgctg acaacctcac ttcctgactt tacggcaaac 3740101 tcaggcagcc agattgtcca attgttcggt cccttctcgt ttattatgct gatcattgtg 3740161 ctatttgggc aaatggcaat caatgttttt aacctgtatg gggctttcat gtccacgaca 3740221 acaacgctgg agccgtttct gaaattaaaa gtcacgccca aagtcagaat catcatgatc 3740281 ctgggtgtca cgcttgtcgg cacagtctta agcctactgg gacagagcaa ttttatggaa 3740341 ctgtttttga attttatctt tttcatcagt tatttcttaa ttccgtggac ggcaatcaat 3740401 ttagtcgatt actacttcgt ccgccacgga aagtatcaag tcaaagccat gttcgacgta 3740461 aacgggcctt atggaaaggt caattggatc accacaattg cgttcgttct gtctatcttg 3740521 ctggaaattc cgtttatcaa cacaagcttt tacatcggac cgcttgccaa aatgtttggc 3740581 ggcggagaca tcgcatggat tatcggcttg gccgtgcctt ctgtgcttta ctatgtatta 3740641 atgaaaccgc gtctgaaaaa acgggcgggg tatcaagaaa agctgtcttc tctctgaaga 3740701 cagctttttt atcattcaaa tcgtttccac acgcggggca ggatgtcaga tagctcatga 3740761 gcgagcaacg tatgagcgga gtgctcgtcc gtccagagct cggcgcacgc accatgcaaa 3740821 tagaccgcgt ttaatacggc gtgctttgga tcttcatggc agcagagcat ccccaatatc 3740881 atgcccgtca gcgtgtcacc ggttccgccc ttggcgagcg ccccgtttcc ggttggattg 3740941 agccagcagt ctccatcagg aaacgcgatg acggtttggt ttccttttaa cacaatgaca 3741001 gtctgcagct gagccgccca ttcctttgca tattccgctc tttttttctg caattcgttc 3741061 acgggcaccc ctgtcattcg gaaaaactcg cccgggtgcg gcgtgaggat gacggggccc 3741121 tcccgtttcg gatatgtgcg cttcgccagc gctccggcat ccaaaataac aggacaatca 3741181 gccgtaagca catgatcgac tgcctgctgt acgctttccg tttgcggaag gcccggtccg 3741241 atggcaatgg cccggtacgt ctcttcaagc tgagcatccg ccgccttttt ccagccgtca 3741301 cgccaatagg tcgcctcggg caaaacagga acaattagcg ggattacgtt ttctgatgta 3741361 ccgatgacaa gcttgccgag accgctccgc atggccccaa gccctgcaag cagcgctgct 3741421 cccggcatgt cgtcacttcc agccagcagc aaagccgtac cgtacgtgcc tttatggctc 3741481 tccgcatctc tttcaggaag cgtggccctt acatgctctt ccgtccaaaa tggaacattc 3741541 atctctatcc ctcctctgct ttcttttcct atttttcctg tcccttttct ttttcaaaca 3741601 aaaaagacag ccttttaggg ctgtctttta ttttacagga acatcaaggt gatacaggcg 3741661 gcgatatcgt tcgtttgccg ccagcagctc ctcatgggtt ccttccattt ctgttttgcc 3741721 gttttcgaga aatacgattt tatcggctgc ttccactccc gcgagatggt gtgtaatcca 3741781 taaaatcgtt tttcctttca gcacctcaaa caccgtttcc atcaattcac gttcggtaat 3741841 aggatcgagg ccgactgttg gctcatcgag gatgatgatc ggtgtatcct gcagcaaaat 3741901 cctcgcaagt gcgatccgct ggcgctctcc accggaaaaa cggatgccgg tttcttgtac 3741961 agaggtatga tatccgtcag gcaatgactc aatgtagtca tgcagcttga cctgctttgc 3742021 ggcgcggcgc acatcctcgt cgcttgcttc tccgtttccg agcctgatgt tgttcaaaat 3742081 gcttgtatca aacaggtgcg gtttttgatt taacacggcc accgcatccg caatctgatc 3742141 ctttaacagc gctgtctcca ctccgtttaa cgtcacagaa ccggagtccg gtttcaaggc 3742201 gccttcgatt aatgcaagcg atgttgattt cccagagccg cttcggccga gcagcgccat 3742261 tttttctcct tggcgcagcg taaaggaaaa gttgtgcagc acttggctgc tgttgtcata 3742321 agaaaacgtc acatcacgaa aggccaaggt gacatcttga agatcgagaa tttgatcccc 3742381 tgattcagtt tgtgacgcct ccggctgagg agccacattg ttcatgcgtc tgatagaatc 3742441 ctgatagccc ggcacttcgc ctaaggcatc cgaaagcggc aaaaaggctt ccgtcaacgg 3742501 aaacaccact agcacaaaag cggcaatcat cgttttagcg agctcgccgt ccgcttgctg 3742561 tcccgctgtc caaaacagca tcagcaaaat aaggccagcg acaaggcatt gcgcagcaaa 3742621 gtcccgccat cttgtaaagc gttgtttttt ccgttcaagc tcaaaccaat cacgttcctc 3742681 tttttcataa gcatcaataa aagcatgccg gcgtccgctg aacatccagt cgctgacacc 3742741 catcacagca tctgtcagac ggctgtacag cacattccgt ccgcttttca gcttcgcatt 3742801 cttcgctctc gtcacgagca aagacacaac cggaaacaat acaacaagaa caaacaaata 3742861 cagcgcaagc aatatggcaa acggccaaga gaagaagccg agcgctatca ctgacacagc 3742921 atacaggagc aaggctgaga tcgcaggaaa aatcgttttt aagaaagcat cctgcaaatg 3742981 ctcaatatcc tcagacaaaa tgccgagcat atcccccgtg cgaaaacggg aacgcagcat 3743041 caaagcaccc ggctcaagca tattgtaaag gcggacgcgc atgtcagata cgattttcaa 3743101 aatgatgtga tggccgacga gccgttccac atatcgcgac acagagcgcg caatcccaaa 3743161 ggtgcgcaca gcgacaatcg gcacataaat gagcagaatg ttttccggcc ttgtcgccgc 3743221 tttagaaatc aaaaaacctg aggtgaacat gagaaaagca gcagaaaaaa tcgtcaccgc 3743281 acccaaaaag ataaccagaa cgaacaggcg ggcattttgc ttgatatacg gcaaaatcca 3743341 ttcttctttc ttcatgctct ttcccccagt tgtgccttca cgagtttggt atacacaccg 3743401 tttttctcca gcagttcatt gtgagtccca atttccgcaa ccctgccccc gtcaagcacg 3743461 ataatttcgt ccatatcgag catccagtga aggcggtgag tcgcgagaaa gacgagctta 3743521 tcctcaaata aatccagcat cgtttctttt atttcatatt ctgtttcgat atcaagatgg 3743581 gcggtcggct catccagcag caggatcgga cggtttccca aaaaggcgcg ggccagcgcg 3743641 acacgctgtg cctggccgcc gctgagcgcc cggccgcctt ccccgatccg cccctctaat 3743701 ccgtcaggaa ggttgttcac cagctccgtc agtcccgctg aggcagcagc acgtgttgta 3743761 tcctctgccg aagcgcttgg atggtagaag cgaatgttgt tgccaagcgt atcatcaaaa 3743821 atgtacggat gctggggaat gtaaagaagg ttcttctgcc agctgccgtc ctgcaaatgg 3743881 gaccggcttg taccattaac ctcaatcatc ccgccatccg gctctaaaaa tccgccgaga 3743941 atatcaatta atgttgattt tccggcgccg cttgcaccga taatgccgat ttttttcttg 3744001 cctttgaatg agagatgaat atcagacacc gaacggccga ctgacacgcc tgacagcttc 3744061 agctcatcct gatcggacca agcttcgagc tgaagcggcg tctcttcttt aaaaccaggc 3744121 tgcgacaaaa tctcttgaat ggtttttcct gcttcctggc cgttcagcgt tgcatgataa 3744181 tcattcccca cttcccgcac cggcaaaaaa tactcaggcg ccagaataag cgccgttaaa 3744241 gcagggccaa gcaaaatatc gccgtcaatg aggcgcaggc ccagaaatac tgcgactgtc 3744301 gccaccgaca gcatcgtgaa aaaatcgagg gcgaatgatg acaaaaacgc cacccggagt 3744361 gtgctcatcg ttgccttgcg ataccgctca ctcacataga aaatattttt gctgtgtgac 3744421 ttgctcaaac ctaggaaacg caatgtctcc agcccgcgaa gagaatcaac aaaatgattg 3744481 gaaagtctct gataggattt ccactgacga tccgcttttc tctgcgcgac aaggccgagg 3744541 agaatcataa agatgatcag aatcggcata gcagcgacta aaatgatggc tgatgtccga 3744601 tcctgaaaaa acacataaat gacaactgcc gcaggcacaa tcgccatgct gaccattttc 3744661 ggcagaaaca gctccaggta gcggcggaac tggctgatgc cttccatcgc cagcgtcacc 3744721 atttgccccg tcccctcttt ctttgcaaag cgggggccta atcggaacag ctgatcaaga 3744781 aaacttttcc tcaaatctgc tcctgtccgg gcggcgtatt gatagacgat tttctgtcgc 3744841 gccaccgtca tcccgtgccg ggcgataaaa gcgatgagga aaaagccgat caccggtaaa 3744901 agggaggtaa tgcccttccc gttgaacagt ccggttacgg cctcactcag ccactctgcc 3744961 tgcataataa tggcggctgt ctgaatcaac gttaaacaag taatcaaggt gagaatccgc 3745021 ttcattcctt tatatcgaaa caggtctttt cccattaata agtcataggc tccttatggc 3745081 tgacgcgctt ccggaagaca taatagctcc agatctggct gccgatgacg aacggcaata 3745141 gcgttaatgc tgcaattgac atgactttaa gcgaataatc tccagaagaa gcgttagcta 3745201 ctgttaaatc gtatgcgcta tgaagcgagc tgaccattac acgagggaat agggaaataa 3745261 agatcattcc cacggtcagc gccagaccag cgcctgtcat cccaaatgtc cagccgtctt 3745321 ttttcttacg aataaataca gccgcgagca taaagcagat gacaatcaaa acagcgagcg 3745381 gaatggtaat ctcgccgcgg cgtgtaaaca tgtctgtctg atacgcagaa agggccgcga 3745441 aggcaagaac cgctacaaaa acaacaccca ttatcttttg cgccattttc cgggcgcggt 3745501 tttgcaaatc accaatcgta cgcagcgtga taaacattaa tccatgctgg aagcaaagaa 3745561 gcgttaccgt cacaccgcca agtatagaat atacattgat ataatcagat acatgtgcgt 3745621 gaatgttcat gtcggcatca atcggcatcc cgcggaataa tgtcgtgaac agcacaccaa 3745681 gcacaaacgg aggaattaga ctgccgaaaa aaacgaccca gtcccaaacc tttacccatt 3745741 ttaaatgatc caccttgccg cggaactcaa acgcgacccc gcggcccatt aacgcaagca 3745801 gcactatgac aaacggaatg taataaccgc tcagcatcgt tgcataccag tttgggaatg 3745861 ccgcgaaaat ggcgcctgcg ccagtcaaaa gccacacttc attcgcgtcc cagaacggcc 3745921 cgatcgtgtt gatcagcact ctgcgttcta attcattatg gccaagaaaa cgggtcgcca 3745981 tgccgacccc gaaatcaaag ccttccaaaa agaagaatcc tacaaacaat acagcaacga 3746041 gtataaacca aagatcatga agagatgcca tggtatacct cctgactaaa tggatctgtt 3746101 gatacaggca catcatgatg attatcatgc tccgcacctt ttttaatctc acggataaac 3746161 aagaagacaa gcagtgcacc aagaatcatg tacatcacac cgaatgcgat gattgagaat 3746221 aacaaggaac ccgctgttac gttaggcgac acagattgag cggttgtcat taaccccata 3746281 accgtccaag gctgacgtcc gatttctgtc ataatccagc ccgcggagtt tgcaagaaac 3746341 gggaaggaaa tcaacgcgat catgatgcgc aaataccatt tgctgttttc aagcttttta 3746401 cggcggttta accaaaggcc gcctaacgca gcaagaatca tgacaacacc tgctcctacc 3746461 atgatgcgga agctccagaa tgtcgttttc actggcggaa tgtagtcgcc ttttccgtat 3746521 attttttcgt actcagcctg aagggttttc atccctttga cacttccgct gaatttctga 3746581 taagccaagt agctcaaggc ataaggaact ttgatttcat ttgagctttt ttcatttttt 3746641 gtatcgatcg tcgcaaaagc ggtccaagca gcagggtcac cgctgtcttc ccataggcct 3746701 tcactggcag ccattttcat cggctgtgat tccatcaagt gctcagcctg catgtgtccg 3746761 ctaaggccga cgccaagacc ggcacaaaga ccgacgatca ttgcgagttt aaaagattgc 3746821 ttaaagaacg gcacttcttt tttcttcagc agtttaaaag cactcactcc ggcaataaag 3746881 aaagctccag tggcaagcgc accgaaaata acgtgcggga attcaaccca aagctgaggg 3746941 tttgtaatca acgcgccaaa atcattcatt tccgcgcggc cgtttttgat cgtaaagccg 3747001 accggctcct gcataaagga gtttgctgtt aaaatccaga aagatgacat gatcgttccg 3747061 aatgatacga gccatatgca gagcgcgtga attttcttcg gcaggcggtc ccagccaaaa 3747121 atccataatc cgataaaaat agattccatg aaaaacgcca ataatgcttc aatcgcaagc 3747181 ggagcgccaa atacatctcc gacaaaacgg gagtaatctg accagttcag tccaaactgg 3747241 aattcttgca aaatccccgt tacaacaccg actgcgaaat ttattaagaa taagtgtccc 3747301 caaaactttg ccattttgag atacagctca tttttcttta caagataaag agtctccatc 3747361 aacgcaacca taaacacaag cccgatagac atcggcacaa acaagaagtg aaacaacgtt 3747421 gttgatgcaa attgtatgcg ggctaatacc aattcactca tgctttctcc tccatttccg 3747481 gttaaaactg ttaatttgct cactacttca caaatagaac cgagactttg atcagtaatt 3747541 cacaaaatag acgaaaaaaa tattgctcaa tatttcacaa atgtgtcaaa aagtcatcca 3747601 atatgatgca agattgccag actgaccaaa tgacacaatc tctgactggt tcatattaag 3747661 tactttacaa cgattcattt caaaaataaa gcctaaaata cctaaaaagt cccgcactat 3747721 gtgacggatt tttgtctatt ttgttgctta tttatgtcgg ctgctaggat aaatgaccct 3747781 ttattatcgt acatcaacac atcgttcctt gcgaacaaaa tgcttgcccc cgccccagca 3747841 ctcgagtctc agcattccgt cttaaaccga ttttagtcag aatgcctctt ttcatttgaa 3747901 ccggtaagag gagaaaagtt gaatagtaaa tttttaatat attaataatt tcaatttttt 3747961 agtatactta acatagtgaa caatttcact gcatcaagaa taggggaggt ttttcaatgg 3748021 gagagcttca aacacacatg caattgcaaa cggatacaat tcacgaaggg gttcgaaaag 3748081 agaattggtt tgcgaaagcc atgaatataa aagtaggcat cataccgctt cctgtgtatg 3748141 ccttgctgtt tatattaatc actgtttttg ttatgcatca cgatgtaaaa agtgacattt 3748201 tgacatccat tgccgtcatg gcgtttttcg ggtttacctt tgcccaaatc ggcaaatcga 3748261 taccgattgt tcgttctatc ggcggcccgg ccatcctagc tacttttatt ccgtccgctg 3748321 tcgtgtacta tcacctgctg cctaatgata tcgtcaaatc caccacagaa tttacagaaa 3748381 actcaaactt tctatatttg tttatcgccg gtattgtcgt cggaagcatt ctcggcatga 3748441 aaagagaaac actcgtaaaa gcattcatga aaatctttat tccgcttatt gtcggttctg 3748501 tcacagccgc tattgtcgga ctggctgtcg ggacattgct cggactcgga tttcagcata 3748561 ccctgctgta cattgtcatt ccgatcatgg ctggaggagt cggagaaggc gctatcccgc 3748621 tgtccatcgg atattctgac atcatgccca tttctcaagg ggaagcgttt gcacttgttc 3748681 tgccatcgat tatgctgggc agcttgtgcg cgattattct agcgggattg ctgaaccgaa 3748741 tcggaaagaa aaaaccggaa tggacaggca acggcaaagt ggaccgctcc gaagaagagt 3748801 cccctgcgct ggaggaatct caaagcggac agcaaatgtt caacctttct ttatttgcgt 3748861 caggcggtat ccttgctgtt tctttatact tagtcggcat gctcgctcac gattttttcg 3748921 gttttccggc acccgttgcc atgctgttac tggctgttct aatcaagctg ttcagattgg 3748981 tgcctgcctc aattgaaaat ggcgcgtttg gagtgtcccg cttcttttca acagctgtga 3749041 cctacccgct tctctttgcg attggggtat ccatgacgcc gtgggacaag cttgtcgccg 3749101 cttttaacct cagcaatatt atcacgattc tgtctgtcgt tgtgaccatg atggccgttg 3749161 gcttcttcac tggaaaatgg ctgaacatgt atccgattga aaccgccatt attaatgcat 3749221 gccattctgg gcaaggcggc acgggtgacg ttgccatttt aagcgccgct gaaaggcttg 3749281 agctaatgcc tttcgcccag gtgtctaccc gcatcggggg cgcgattaca gtatccttaa 3749341 ccttattgct gctgcaccag ttttattgat ccccgcaagc aagttcttcg tcaaacgaaa 3749401 gagcttgctt ttttgcatgt ccatgttttt gcaagttccc atcccatgct atagtaatag 3749461 ttggaaatac tagatagaaa ggaatctggc atgcctatgg gaactcatct atttctcttt 3749521 atgcttctcg ggctgggatt ttatttgata tcagccctag ctgcaaaact cattccggcc 3749581 atagacttct ggattgatat tgttctatgg gtcggcgctg cggcttacat cttctctcat 3749641 ctctcattca tggacggcat tgtctcactc gcgacaatgt tctactgcta ttggaccgca 3749701 atggatctca ttgtttcaga gcgtgtggaa aaaccttcgg gagactggca ggaaatcgag 3749761 cttgccaaaa acaaaacacg cctcctgtca gacattacgc tgaccgccat tgtgtttgca 3749821 ggggctgtca tttttttcat ctatggacct gacacaagcc ctctcaaata tgtgatcctt 3749881 ctcggaatga tctccggcgg aggggcactt gtgaagcgaa tactgaatgt ttttagcgta 3749941 aaggtttttt attcagcagc cttagaaaaa ttgcatatca gctcacacta tgaaacccgt 3750001 acatacccgc tttccgattt gaagaacatt cagcttgaat caacagcaga tctcttaaag 3750061 ctccatccgc ttctgacgat gtattcatcc cgtttagatt tgacaacaag ctttcagcaa 3750121 gtcattaaac tgtctcttcc cggcgaaaca ctgtttctga cggtgaagga accgcaaaaa 3750181 tggaaaacaa ttcttcagga atacacagat gcagaaaaca atgtggacaa tgtgatttct 3750241 gttttgccgt tttatcatcg aaaaaatgtg aagcggctgc tcggtaagct ttattttgcc 3750301 gccagcgtaa aaggggtatc cgcttacgcc ttattggtgc tcgcgttata cgcattacac 3750361 gcctctccat gggtcatggc tgttgccgta atcctatatt gggtattcaa catgtatatg 3750421 tcagaccgtg tgttgcgggc ggcgatggac gccaagtctt gtcatcatcc gcatgtacag 3750481 gccgcggccg ataagatttt cagatcggcc ggcatttccc atgtccgcat atacgaaacg 3750541 gagagtgatg attacaacgg aatggcagta ggcatgaatg tcgggaggtc aatggtcatc 3750601 ctgacaagcg ccacactaac acttccacag cgtgtcattg aaggcattct ggcccatgag 3750661 gcgattcata tcaaaaaacg tgacgttctg tcatcacagc ttttgcgttt tctatatctt 3750721 ggagctgtcg tggggatttt cctcttgttt gagcagcata tcacccatcc cgaggcccac 3750781 aaaattgcgc tttgggcttt cattatggca atcattatcc tattccagct ctatcaatcc 3750841 ttttgttcac aatggatgga ggtgcgtgct gacaaccttg gcgcatcatt gctggacggc 3750901 ggttacaaac aaatggctga agccttgaga atcttggcgg ttcggcaaga tgaggatata 3750961 cagaaacaaa gtgcctatag ctctgaagca ggtgaagacg agcttcaaat tgattctctc 3751021 acccgtgata aaagctggtt tttcagattg attgattttc agttcgctcc tcatcctcct 3751081 atgtattggc gtgtcggcac tttattgtca aacaaaggac atggggtgct aaagcgctgg 3751141 ctcagagacc gactgaaaga atcgatcact ttgaaatgaa accggtcagc gtttcatccg 3751201 tataacagat atggtgaaaa aagggagtga cgcgaagtga ttgtgatcat cttattgttt 3751261 atatctatta ttgtttttct ttcagtcatt cagccgcagc cctcgaaaaa caaaagccgc 3751321 cagcaggcgg acagcgggta tttcggttat tcagatcata gctcacacca tgatggatgc 3751381 agcagtgacg gaggtttcag cgattccggc tgtggcggcg gagggggcgg cgattaaacg 3751441 ccgccttttt ttatttcatt gattcgatgt acgcaccaaa agccgagcct gacatgcctg 3751501 gggacacgcg cacacgatgg agggcataca ttccctggtc tctcgaagcc gcgcccggtt 3751561 ctgtcgtcac gcccatttga tagcctgttt tttcagcggc cttcagcgtc tcctcattgt 3751621 agcgccctac cggatagctg atgatggtgg tttgctgatg aaacatgttg tcgaacagct 3751681 ttttcgaatc agccatctca ctttgctgct gttgaggcgt taatccgttc agctcaaggt 3751741 ggtcaatcgt atggctttca atcgatatgc cgtgctgtgc catttccttc atttgttcct 3751801 ctgtcagatg gtgcttatgt ccgatcgatt tgccgatcat aaaaatcgtt gccttcatcc 3751861 cgtacttttt cagcaccgga tacgcatctt gataattgtc ggtgtacccg tcatcaaatg 3751921 tgatcagcac gcacttctca ctcggttttt tatcctgcgt cagcatgaga gatgcctctt 3751981 tcggcgttaa tgtctgatag ccgttatcat gaagccactt catatgcgcc tcgaattctt 3752041 tctttggcac acggaggctg tttcctgaag aaatgctgtg gtacatcaaa atcggcagct 3752101 ttgccggttt ctctgttttg atccatgcgg atgtatcgtc ttcttttttc tgaacttgta 3752161 ctgccttttt ttccggtttc ttttgttccg cttttggcat cggctgctct gcattcgcct 3752221 cttgatcagc acaagccgca agagccaaac agctgcccaa aagaaagatg cttaaaaaca 3752281 atcgtttcat cgttctcctg ctttctgtct atttcttcct cctttttcat cggtttgatt 3752341 ctgagatttt caatagcaaa aaaccggaca tgtctccatg tccggttttt ttgatcttat 3752401 cggattctca cttctgtctc actgtcaaag aaatggcctt tattcatatc aaatgcaacc 3752461 gtcagctcat cgcccgattg aatatcgagg cgggcgtcga tccgcgcaat aaagtcttgg 3752521 ttgtctatct gcgaataaat cataatttca gaaccgagca gctctgcaac attaattttc 3752581 gccttaatcg aagagttctt atatgattcc acgacaatca attcatcatg tatatcctca 3752641 ggacggatgc cgaagatgac ctctttgccg atgtagcctt tttcacgcag cactttcatt 3752701 tttccttccg ggacggttaa tgccgcagaa ccgattttga ttaagccatc cgtgagcttt 3752761 cctttgaaaa aattcatcgc cggtgatccg ataaacccgc cgacaaagac gttttcaggg 3752821 aattcatata catccttcgg cgtcccgatc tgctgaattt tcccatcttt catgactaca 3752881 atccgtgtcg ccattgtcag cgcttctgtc tggtcatgcg tcacataaat cgttgtagtc 3752941 tgcaatctct ggtggagctt aatgatttcc gcccgcattt gcaccctcag cttcgcgtcc 3753001 aggtttgaca aaggctcatc catcaggaac acctttgcat cccgcacgat tgcccggccc 3753061 agcgcaaccc gctgtctctg tccgcctgac agcgctttcg gtttacggtg caaatattcc 3753121 tcaagcccga gaattttagc ggcttcttcg actctttttt tgatttcagg cttcggcatt 3753181 ttccgaagct tgagcccgaa cgcgatatta tcgtagaccg tcatatgcgg ataaagcgcg 3753241 tagttctgaa ataccatcgc gatatccctg tcctttggcg ctacatcatt gacccgtttt 3753301 ccttcaatat aaaaatcacc tttcgaaatt tcttcaagtc ctgcgaccat tcgcagcgtc 3753361 gttgatttcc cgcagccgga cgggccgacg aatacgataa attccttatc ggcaatatga 3753421 aggttaaagt catcaaccgc cggttccttc tgatcataaa atttataaat gtgctccatc 3753481 cgcaattcag ccatctaaca tccccctttg ttattgtaaa cgctttctta tattgagtgt 3753541 aacagcaatt ccctctcgct aaaatgggca gcgttcataa aatcacccag ccatttttcg 3753601 tgcatatttc caatttattc tgaactttca ttttgcaggc agataaaata ggcaagaagc 3753661 gcgcctttgt acgatttgat atctatccct gaccgctcaa taaatttatc aatccgatat 3753721 tgcaggctgt tgcgatgcag atgcagcttt ttcgctgtta atgtgacgtt tgagttgttt 3753781 tcaataaaca gcttaatggt cttccttagc tcagattcac ttccaaataa aagctcagct 3753841 tcttcagaga gcagtgtttc cagtttttct ttttctgttt ctaataatag aaaaggaaag 3753901 atcatctcaa aggtcacact ctgcacctga ggcagccgtt tttcagcaaa caggaaatac 3753961 gcctgttcac gagcgtaatg ttttcgcaga cactcatccg gctcgtaaaa tcttccggcg 3754021 taaaaacgga cactgaagta gaaatcactt tcaagaacct tagcgagcga ttccagttcg 3754081 tccttctccg ccgccgcttc actttcctgc tcgacaatca cacctctgtc ctcatggatc 3754141 cacacaatca caaaagacac cggccaaaaa tggcgaaccg cttccgtaaa ggacgtcctt 3754201 tctattttgc cgaataaatg aaagtgaaca aatctcgtcc gtttctttat atacgccggc 3754261 aattcccctc tggaaaaaag gaacgaaaac cacttgtttt cctcaggtga tttcatagac 3754321 agttgattgc cctcatccgc aggcgtcaaa aatgactgca gcaccaatac ttctttttca 3754381 ctgatctctg ttttcggaat ggagatatat ctctgattgc tctcatcaaa aaaacataga 3754441 cagccttccc ttatgcaaag ctcctcagac acaatcgaac cgggataaat agccagcagc 3754501 gatttcatag agtctcctct cttatgtaag gatctgtata ttcagtataa ggcgaaacac 3754561 acatgttctc cactaaaaaa gagtatatcc ggtatagata gacgagaaac tgaaagggaa 3754621 acctcattcg tttacatatt ggcttcagcg gaaatagaag aagacatgca ggaccaaagg 3754681 agggtcatct tatgagtttc gaaacgttaa acaaaagttt tatcaacgga aaatggactg 3754741 ggggagaaag cggacgtacg gaggacattt tgaatccgta tgaccagtct gtgatcacaa 3754801 cagcatcttt ggcaacgggc aaacagcttg aggatgcgtt tgacattgca cagaaagccc 3754861 aaaaagagtg ggccaagagc acgacggaag accgaaaagc cgtgctgcaa aaagcgcgcg 3754921 gctatttaca cgaaaaccgt gatgacatca ttatgatgat cgcccgcgaa actggcggaa 3754981 cgatcattaa atcaacaatc gagctggaac aaacgattgc gattttagat gaagccatga 3755041 cgtatactgg tgaattaggc ggcgtcaaag aggtgccatc cgacattgaa gggaaaacca 3755101 ataagattta ccgccttccg ctaggtgtca tttcatcgat ttctccattt aatttcccaa 3755161 tgaatctatc catgagatcc attgcgcccg caattgcgct gggtaacagc gttgttcaca 3755221 agcctgatat ccaaactgct atttccggcg ggaccatcat tgcgaaagcg tttgaacacg 3755281 ccggtcttcc tgccggtgtc cttaacgtca tgctgacgga tgtaaaggaa atcggggacg 3755341 gcatgctcac caatccaatc ccgagattaa tcagctttac agggtcaaca gcagtcgggc 3755401 gccacatcgg tgaaatcgcc ggtcgcgcct tcaaacgaat ggcacttgag ctcggcggca 3755461 acaatccatt tgccgttctt tcagatgcgg atgtcgatcg tgctgtggat gccgcgattt 3755521 tcggaaaatt tattcaccag ggacaaatct gtatgattat caacaggatc atcgttcatc 3755581 aagatgtata cgatgagttt gtagaaaaat tcaccgcccg tgtcaaacag cttccgtacg 3755641 gcgatcaaac cgatccgaaa accgttgtcg gcccgctgat caacgagcgc caaatcgaga 3755701 aagcgctgga gatcattgag caggcaaaga cagacggcat tgagcttgcg gttgaaggaa 3755761 aacgcgtcgg aaacgtgctg acgccgtacg tctttgtcgg tgcggacaac aacagcaaaa 3755821 ttgcccaaac ggagctgttt gccccaatcg caaccattat taaagctggc agcgaccagg 3755881 aagcgattga catggcaaat gatactgaat acggcctcag ctctgcggtt ttcacttctg 3755941 atttagaaaa aggcgaaaag ttcgccctgc aaattgacag cggcatgacc catgtcaacg 3756001 accagtccgt caatgattcg ccgaatattg cctttggcgg aaacaaagca agcggtgtcg 3756061 gccgtttcgg caatccgtgg gtcgtcgagg aatttaccgt gacgaaatgg atttcgatac 3756121 agaagcaata ccgcaaatat ccgttctaaa tgaaaaaatc cctctgtttc aagtacagag 3756181 ggatttttct ttatttagat atatccacaa acccttcgcc aaacacatcg cgtacgtcat 3756241 gtacgatcac aaacgctttt ttgtcgcagc ttctaatgat ttttttcagc atagacagct 3756301 cctgtttgtt aatgacgata tacaaaatct cttttgactg gcccgtataa tttcccttcc 3756361 ctgataaaat cgtcacgccc cgatccatca aggtatttac ctgctctgca atctcactct 3756421 tattttctga aatgaccgta atggcttttt tcgtattcaa accttcaata atgaagtcca 3756481 tcactttggt accgatatac agcatcacga tcgtaaacat cattttttct gcaccaataa 3756541 taaaataaga gctaaatact acgattaaat caaaaaacaa gagtgcatag ctgatattcc 3756601 agtctaaata tttattagca attctggcca gaatcgcgga accggccgtc gtcccgccga 3756661 cccggataat catgccgatc ccgactccgg caaatacacc tgcgaaaatc gtattaatga 3756721 tcaattcatc agacggaatg ctccacccat gtgtcagatg aagaaaaagc gaatttgccg 3756781 caaccgcaat gatcgtataa accgttgttt ttccatcaag aaacttgtag ccgattaaaa 3756841 gcaaaaacgc atttaagata aagttcgtga caccaggaga ccattgaaac agataataca 3756901 aaatcagcgt aatcccagtg actccgcctt ccccaagatc attgggaatc gcaaataaat 3756961 taaccgcaag cgcgaagaaa aaagcgccaa tcacaagcat aagtacatcc agcattctct 3757021 ttttcatcac gaaaacactc cttttcattg ttctgttcta gcaaataaaa aaacccagga 3757081 gaacgctctc gaaaaagagc agaaactcct gggcttttat cccaccgtgt cataacagcc 3757141 aagctgctat gtgttttctc tcggtcacag tccaatttgc attgcggaac cctagaaaac 3757201 cactgttttt atcatatcct tttcactttc caatattagc attataaggg acggttcgaa 3757261 ttggttcaag gggtatttgc ggagttttca tcagataagc tggaaaaaaa tacgatttat 3757321 ctattaaaaa agaacagata taaccgataa gaaaaaaagc atatatttta caagcgaatg 3757381 taactataaa tgataataat tataagaaat tcataatttt atattgacta agagaaataa 3757441 tataggcatt atagtacata tgtttcgtac attttattac ataggaggaa atataatggc 3757501 aggaaaacta gtaccctgta aagcttgcgg tcaagaaatt gcaaagggtg taaaaaaatg 3757561 tcctaactgc ggtaaggatc aacgtaactt ttttatgcga cataaaatca ttacgtttat 3757621 tctcgcagtt gttgtcatca ttattatcgg taatatgatt ggcggcggag gcggctcaga 3757681 agccacttcc aaaacatcaa gcagcagcaa agcagaaact gaaaaaacat acaatatcgg 3757741 tgataccgta aaaactgaaa aaactgaagt gacggttacg aaggtagagg acagagatac 3757801 tgtcggtact caatatgttg aaaagaaagc atctgaggga ggtacaattg tagctgttca 3757861 atatacaatt aaaaacgtat ctaaaaagcc gattagctct ttttcaattc caactgttaa 3757921 attagttgat gctgatggta cttcttatga ttctgatatt gatgcttctg taaactatgc 3757981 aactgagaca aaagttgata actctaaaat tttgagtgat ctaaatccta atattaaagt 3758041 aacaggtgta aaagcatttg aagttgacaa ggaagcttat gcaaaaggca cttggaaact 3758101 aaaattcagt aatgatgtta ttgtgaaaat caaataacag ctaacaaggg tgcctgttta 3758161 ggcacccttg ttctttaaaa aaggccttct caattgagaa ggcctccatt cttattccgc 3758221 actcttatac ccattcacat tagaagactg ccatctccag gaatcagcac acatttcctc 3758281 aaggccgcgt ttcgcttccc agcctagttc tcgcttggct ttcgcaggat ctgcaaagca 3758341 tgtggcgatg tctcccggac ggcggtccgc aaaacggtat ggaacctctt tccctgacac 3758401 tttttcaaag gctttgacca tttccagcac gctgtagcct gtgcctgttc caaggttgta 3758461 tgcatcggct cctgtagagt tcaatacttt ttccagcgcc ttgacgtggc cttctgcgag 3758521 atcaacgacg tgaatataat cgcgtacgcc tgtcccgtct tttgtcggat agtcatttcc 3758581 gaatacgctt aattgctcga gcttcccgac tgctacctgt gccacatacg gcataaggtt 3758641 atttgggatt ccgttcgggt cttcaccgat ccgtccgctt ggatgcgcgc cgaacgggtt 3758701 aaagtaacga agcagcgcaa cgctccactc attgtcggct gtatgcaaat cacgcaatat 3758761 ttgttcaagc atgagcttcg tctgcccata aggatttgtc gcgcctaatg gaaagtcttc 3758821 cgtaatcggc gatgtttccg gaacgccgta tactgtcgca gatgaactga atacgatttt 3758881 cttgacgccg tatttctcca tggcctcgca taaaataaac gttcctgtca aattgttatg 3758941 ataatatttg aggggaatcg ccacagattc gccgactgct tttaaccctg caaaatgaat 3759001 cacagcttcg atttcatttt cagcaaaaac ggaatctacc gcttcccggt ccaataaatc 3759061 cgcttcgtag aacgttaaat cttttcctgt aatctccttg acacggttca gcgcttcagc 3759121 tgaactgttg gacagattat caagaacaac aatctcgtag ccgctgttca atagttcaac 3759181 acatgtgtgg ctgccaatgt aaccggcacc gccagtaaca agtattgcca tgatgtaaac 3759241 cctcctaaaa aatgacctgt tttcattata tagtgtttag aaccggtcca catccatttt 3759301 taagaagttt aatcgtttat taatagtttt ttcatatttt ttagcttaaa cccttgccag 3759361 caattcgata gaggtttcag caagaatgtg ctctttcatt tcttgataga gctcattcaa 3759421 gtaaaagccc ggctgaagat tcagctcagc atctaaagca tagaccgtca atgtatacgc 3759481 atgatccttg tcaggcggtg tcggcccgca atactggtga atcacctttg gatcgttgct 3759541 tcccgcaagc ggtgaagcaa agctgttttg cccttgtatc atcaagtcct gtctttcctc 3759601 actcgcatgt tcaggaagct ctccgatgta agccggaata ttagccgctg tccagtgaat 3759661 ccagctgaat ccgcatacgg gaatggcgtc atgatcgatg aaagtaagtg cgagcgtctt 3759721 tgctccggac gggatgtcat caaaatgaat tggaaaggat acaaatgggt ttccttctct 3759781 cttatatttt tcatccgcgt attttgaata cttgtcatgt aaatatggat ttgcttctac 3759841 gtatatgttc atatgaatcc ctctctctat tttctcgttc tataggtata ctaaacgaat 3759901 cgatgtataa tcagtgataa acaaatacgc atgtaaacgt aacaatttgt tatggataac 3759961 ttgcagtgaa ggagatattt catggattta aaatggctgc aaacctttat tgccgcagcg 3760021 gaatcagaga gcttcaggga ggcggctgag catctgtatc tcacacagcc tgccgtttct 3760081 cagcatatga ggaaattgga agatgaactg gacatgaggt tgtttttgca tagcggaaga 3760141 cgagtcgtac tgactgacga aggcaggctc tttttgcctt atgccaaaga aatgatccat 3760201 gtttaccaag ctggaaagca gaaagtcagt caatggaaac aggggtacag ccgatcactc 3760261 acgctggccg tacaccccta cattgcgtcc tatatcttgc ctcgctttct gccagcctat 3760321 atccaaaaac atccgcatgt cgagctttca actcatgtgg ctggatctga cgctattaaa 3760381 caagcggtgg aacacaatga agctgatatt ggtttgtcgc ggaaagaccc gaacaccaac 3760441 actctttatt atcagcatat atgcgaaggt acgctttgtc tggcggctcc tttccaagaa 3760501 agcagaccgg atgctgcatc cgtcttaacc cgctatcggc tgctaacgca tgatcatccg 3760561 tcatatgggg atgccttttt agataacatc cgatcacatt acccgtatct tcaaatgatg 3760621 gctgtcgggc agacggatac ggctgtccac atgatgaaag cgggaatggg ggcatctttc 3760681 ctccctacct acattatcaa acaggaagaa gccgaaaaaa agctgatggc tgtcagcacg 3760741 cctgcacatc tagaattgcc tgcgtcccaa acgtttatga tgtggaaaag aaacagcgaa 3760801 gacattcagc attttcacgc catgttacat gactttatgc agcgcgaaca agtatagagc 3760861 tgaaaaatca atctgccggt tgacgttttt ctttcctatt ttcgctatgc ttaatgcaga 3760921 aaggatttga tgacatggcg atgagccctt atatttttat tgtattgatt cttattattt 3760981 tatcgatgta tcgagaaaga acggtaaagc ccgggaagtt gctgatcatt ccactgttgc 3761041 tcttatgggg cgtatctgca tcgtttcagc cggcgtattt tcattccgta ttacatgtgg 3761101 cgatcagcgg cattttatta ctgatcgggc tggcctgcgg gtttggcatt gggaagatgg 3761161 taaatgtacg gattcacccg gaaaccggaa aggtcacttc acgcggctca cttgggagtg 3761221 ttatcctcat tctagtgata ctttctttgc gcatggccgc gagaacatgg ctgcctgaga 3761281 gcaacgagat gtttattgcc attattcatt ctatgttctt cgttcccctc ggcaccatca 3761341 cagcccgcaa catcatgctt tacaaagcat acagacgact gaccgctggc aaagtatcca 3761401 ttcaataacc gaaagaagga ccagcatgaa cggacaaact ccggctcggc actactacaa 3761461 gaagcttgtg ccgagcctta ttctcatttt gaattgcata caatttttat ctcatccaac 3761521 taaggctgat cccattttgt tagcatttgt atttgcggta tacttagcat tcatttggat 3761581 cattccctat gtggcatcca ctgctgttag tttgagcata ttcatcggac tctggctcct 3761641 gaccgatttc ttttgggctg tttccggcca agagcagggt gccgcctatt ttttgattgt 3761701 atttttaatg atatatgccg cctttagact cccttcacgg ctatccttga tcttcacagc 3761761 atgtttaatt ggaggcaaca tattactcct atcctcacaa gggggaagct tgaataccat 3761821 catcagcaac atctcgatca tgctcggtct gtacgtcctc ttctcctcca tgcgtttcag 3761881 acgagaagcg agaagggagg ctgaacggaa tcatgctgaa ttggcaaaaa tgcatgtgca 3761941 gctggagcat gctcataaag aactccagaa agcgcatgca gagctgcagg aggcttctgt 3762001 tctttcatta aggtacgcgg tccttgagga acgtacaaga attgcccgcg acattcatga 3762061 cagcatcggt cacgagctga cttctgtgat tgttcagctt caatcccttc cctatatcct 3762121 taaaagcagc aaggaggatt cagaaaaagt cattcaaaat gtactgagtg tcgccaggga 3762181 gtgtcttcaa gaagtgcggt ctgttgttca ccaaatgggc cgtagtgaat cgatggtggg 3762241 gcttaccgct ttgcgggggc tcattcatca agtggaggaa cggagcggct tgcacgtttc 3762301 tttagatact gccggactgt cagaagagtc ttggcctcca aacgtgagcg aaacgatcta 3762361 ccgcatcttg caggaagcgc tgaccaatat cattcgtcac gctgacgctt ctcatgcggc 3762421 ggccgtcatt tctaatgaca agtcccatct ctatgtcaca atcaccgacg acggacaatt 3762481 caccggcagc cttacttatg gatttggcct gacaggaatg aaagagcgcg cagaaaaagc 3762541 aggcggttcc cttactttca gtgccgtaca gccgagcggc ctgaaaattg agctgtcatt 3762601 gccgctcatg acaacgaata aggagcaaaa agatgaacaa agataaaata cgcgtagcgc 3762661 ttgccgatga tcagccgctt gtgcgtgaag gcttccgcta cgtcatcaac gcacagacgg 3762721 atatgacggt ttctggcgag gccggcgacg gtcacgatat tatagcactc gcaaaacaaa 3762781 caaaacccga tgtcatcctc atggatgtcc agatgccgcg ttgctcaggc atcgaagcgg 3762841 cgaaagacat tatgtccgca cttccaaata caaagatagt cattttaacc acctttgaca 3762901 cggaagaata cgtatttgaa ggcatccgtg cgggcgcagt cggctatctg ctgaaggata 3762961 cacttcctga ggagttgata gatgcgattc gcgctgcggc cagaggcgag gcgattttcc 3763021 gtacagtcac agctgctaaa atcatcagtg agacatttcg ggcgaaacag caaactcatg 3763081 ccgaagaact ggcagagccg ttcaccaaaa gagagcttga ggttcttcag caaatggcct 3763141 acggactgag aaatgaggat attgctgaaa agcttttcgt cagtgaaagc actgtgaaaa 3763201 cccacgtgca ccgcatcctg caaaaatgca atgcccaaga ccggacacag gcagtcgttt 3763261 ttgccattcg aaacggtatt gtgcaataga aatctctcat cccgccatgc taaaataaga 3763321 caaaggagat gattggaaat gaaagaagaa atcattgaac ggtttactac atatgtaaaa 3763381 gtcgatacac agtccgatga atccgttgac acttgtcctt ccacacccgg ccaattgaca 3763441 ttaggaaaca tgctagttga tgaattgaag tccatcggca tgcaggatgc agccattgat 3763501 gaaaacggct atgtcatggc aactcttccc tccaatactg aaaaagacgt gccgacaatc 3763561 ggctttctcg ctcacgtcga caccgctaca gactttaccg gcaaaaatgt gaatccgcaa 3763621 atcatcgaaa gctatgatgg aaaagacatc gttcttaacg aacagctgca ggtcaccctg 3763681 tcacctgatc aattccctga gctgtccggc tataagggcc atacactcat caccacagac 3763741 ggcaccaccc ttctcggcgc agacaataag gccggtatcg ctgaaatcat gacagccatg 3763801 gattacctca tcaaacaccc tgaaatcaag cacggcacaa tcagagtcgc ctttacgcct 3763861 gatgaagaaa tcggaagagg gccgcacaaa tttgatgtga aacggttcaa tgcatccttt 3763921 gcctacacgg ttgacggcgg gccgctcggc gagcttgaat atgaaagctt caatgccgct 3763981 gccgcaaaaa ttacgattaa aggcaacaac gtacatcccg gaacagctaa aggaaaaatg 3764041 atcaactctg cgaaaatcgc gatgaagctg aacagcctgc tgccggcaga cgaagcgcct 3764101 gaatatacgg aaggttatga aggcttctac cacctgctgt cgattcaagg agacgtagag 3764161 gaaacaaagc tccactacat tatcagagac tttgacaaag agaatttcca aaacagaaaa 3764221 gaaacaatga agcgtgccgt tgaagaactt caaaacgaat acgggcaaga ccggattctg 3764281 ctggatatga acgaccaata ctacaacatg agagagaaaa ttgaacctgt catcgaaatc 3764341 gtcaacattg ccaagcaagc gatggaaaac ctcggcatcg aaccgaagat ttcccccatc 3764401 cgcggcggaa ccgacggatc acagctgtcc tacatggggc ttccgacgcc aaacatcttt 3764461 acaggcgggg aaaacttcca cggcaaattt gaatacatct cagttgacaa catggtcaaa 3764521 gccgtaaatg tcatcgttga gattgcaaag cagtttgaag cgcaagcata acgccaaaag 3764581 ccagtccaaa aaaggactgg cttttttgtg tgaaaatgaa acattttaaa cacgtcctcc 3764641 gtaaaacaag tatcaacaaa tgaggaggaa aaacaatgac aaaacatgca atcgctgcca 3764701 agagtctctt gaaaaaatgg atcatttcca ggccgcttaa catgaaaaag aaatccagcc 3764761 catttcaaaa aatcagaaaa atgttcaaac gcttcttcaa ataaaacatc aaatccccta 3764821 aatacaatcc gtattcaccc gtaccgccca aatgctccgt aatttgggtt ttttgtgttc 3764881 aattccgcaa aatagggtat aaaccaaaca agcaagaaaa cagcacccaa aaacaggtaa 3764941 ttcgaattac gtaaacttag gttaaaagtt atataaagga atttatttta tcgtcgatag 3765001 taactataga accaatcatc aacaagagca aacagcgtaa ttcaagacta ttttcaggtc 3765061 atcaggtaat actgttttag agggacagtt tcttgttatt tattgattta gaattttttg 3765121 aatacttttt ggcattttat ccgtacaata gagagtacca aaactttttt tgggaggtat 3765181 gtaatatgat cctatttatt atcatcgcat tatgcggcta tcttcttttt tctttcagca 3765241 aggacaatcg ccgcaaaccg caaaagacaa gccctctgcc agcagccgca cctcatcaca 3765301 acaacctaat cgaccttgac gccatccgcc aaaaacgccg gatgcatctt tcctaattct 3765361 atatttcaaa cgaaaaggct gctgaatcac gcagcctttt aaaattgttt tgatttagag 3765421 cctgaaacct tttcgccacc tatccgtaat ttcatacaag gcaaacccaa aggagacttc 3765481 agcaatgatc gagttattta tgaaacaaaa aatgttctca tttaaagatg catttcacat 3765541 ttatgaccgg gatgaacaag aaacattcaa ggtggagggg cgttttttct cgttaggaga 3765601 ctcattacaa atgacagact catctgggaa aacgctcgtt tccatagaac aaaaactaat 3765661 gtctttattg ccgcgctatg agatttcaat tggcgggaaa acagtttgtg aggtaacgaa 3765721 gaaagtaacg ttttccaaac cgaaatttgt gatttccggg cttaactggg aaatagatgg 3765781 tgatttatgg agggatgaat tccaactgac ggacggggaa aatgtccgga tgtcagtgag 3765841 caaaaagtgg ctcagttggg gtgattccta tcacttgcag attgcatacg aggaagatgt 3765901 tctgatttgc actgccatcg ctatcgtgct tgatatggtt ttatataacg atgaagatga 3765961 aagtattttc taaaaagcat tgacaattga tccaaaagta ataatattaa gataattgaa 3766021 atctgaatat gaagttgtac cttatcaaga gaggtggagg gactggccct atgatacccg 3766081 gcaaccgctg tttcaaacag aatggtgcta aatccttaag aacattgcgt tcttgcagat 3766141 gaggcggaga tttgatcgtt caagctcttc cttacacaaa ggaagagctt tttacatgct 3766201 taatatttca gaaaagaggc gaataacatg gctcaacaaa cgaatgttgc aggacaaaaa 3766261 acagaaaaac aacgcaaagc acctttccgc gccgatcatg tcggcagctt gcttcgttcc 3766321 gttccggtaa aggaagcccg gcaaaaaaaa gcggctggtg agatgacagc ggaacagctt 3766381 cgtgatatcg aaaatcaaga gatcacccgc atcgtggaaa aacaaaaaga aatcggtctc 3766441 gatgtggtaa cagacgggga attccggcgt tcctggtggc attatgactt cctggaaggg 3766501 cttgacggtg tggaaccgtt catcccggct gaggggattc agttccataa cacaaaaacg 3766561 aaagcgcgca gcatcaaagt gacgggaaaa ctcgatttta cgagccaccc agcgctcggt 3766621 gattatcaat ttttacatga gattgccggt aacgcgacgc caaaattgac cattcccagt 3766681 ccaaatatgc tgttttttgg cgaaaaggcg gataaaggga tttatgacga tcaagaggaa 3766741 tactttcatg atatggccca agcgtacaaa aaagcaatca aagccttcta tgatgctggc 3766801 tgccgttatc tccagcttga tgatacgtca tggtctctct tctttgagga caaaggcaga 3766861 gaggttgtcc gggcgctcgg cggtgatcca gaaacattgc cagccatatt tgccaaaaca 3766921 attaacgatg ccgtcgcaga ccggcctgac gatttaacga tcacaatgca catttgccgc 3766981 ggcaacttcc gctcaacctg ggcggcatca ggagggtacg acgctgtagc ggaaacgatt 3767041 ttggacggct taaaccttga cggccttttc ttggaatacg atgatgaccg ctccggaaac 3767101 tttgatccgc tccgttttgt gaagcgcaag gatctgcaaa ttgtgctcgg cttgatcaca 3767161 tcgaaatacg gcgagcttga aaatcctgag gatgtgaaac gccgtatcaa tgaagccgcg 3767221 cgttttgtca gcttggacca gctatgcctg agcccgcagt gcggtttcgc ctctacagaa 3767281 gaaggcaacc ttctgacaga ggagcagcaa tgggcaaagc tgcgccatgt catcgacatt 3767341 gccaacgatg tgtggagata atctatcatt gacagaaata gaaaatgtgt gaataataga 3767401 tactatcaga aaatttaata aaaaggtttt ccttatcaag agaggtggag ggactggccc 3767461 tgcgataccc ggcaaccgct gtttaacaga atggtgctaa atcctttaga gcaatgattg 3767521 ctcttgaaga taaggttgag attgtcacgc aagctcttcc ttatccaaag gaagagcttt 3767581 tttatatttg aatggaaaga aggaatggac aacatgtcac aacaaacaac acccgcagaa 3767641 caaaaatcac ttcaaagaaa aaaaccgccg tttcgcgcgg atcaagtcgg aagcctgcta 3767701 agatctgagc ccgtcaaaaa agcgcggctg caaaaagcgg ccggcgaaat gaccgctgag 3767761 cagcttcgcc aaattgaaaa cgacgaaatc atccgcattg tggaaaaaca gaaggaaacc 3767821 ggcctgaacg tcgtgacaga cggtgaattc cgcagagcat ggtggcactt tgatttcctg 3767881 gaaaacttag atggcgttga gccgtttact cctgagcaag gcattcaatt ccataacgta 3767941 cagacaaaag cacgcggcat taaagtcaca ggcgatatcg acttttcaac tcacccaatg 3768001 cttgaagatt actcatttct ccatagcatt gccggtgacg cgacgccaaa gatgacgatt 3768061 ccaagtccga atatgctgtt tttccgcgga aaactggaaa aggatgaata caaaaacgat 3768121 tatcaacttt tccagcacga tgtatccaaa gcatataaaa aagcgattca agcgttttat 3768181 gacagaggct gccgctacct ccagcttgat gatacagcgt gggccgtttt cttatcagaa 3768241 aaaggcttaa aacaaatcga agcgttcgga acaacgcctg acgagcttcg ccagctgttt 3768301 gcgaaatcca ttaacgacgc gattgcagac cgcccggatg acttgacggt aaccatgcat 3768361 atttgccgcg gcaacttcca gtccacttgg acagcggaag gcggctatga cgcagcagcc 3768421 gaaaccattt ttgacggctt gaatcttgac ggacttttct tagagtatga tgattcacgc 3768481 tcaggcggat ttgagccgct ccgttacgta aaacggtctg atcttcagct tgttcttggc 3768541 ttagtgacat ctaaattcgg tgagcttgaa aatccggatg acgtgaaacg ccgtatcgaa 3768601 gaagcgtccc gttatgtaag cttagaccag ctttgcctca gccctcaatg cggattcgct 3768661 tcaactgagg aaggcaacaa gctgactgaa gaacagcaat gggcgaagct ccgccatgtg 3768721 gttgagatcg ctaatgatgt ttggaaataa gcaaagaaaa aaacacactt gattccctag 3768781 cggagcaagt gtgtttttta tgtcattgtg cggtgtagcc cccatcaagg acgacagcct 3768841 gcccagtgac gcccttcgcc ttctcgcttg ccaaaaacac ggcataatcc gcaatttcct 3768901 tgacggaaag cagtcgcttt tgcggcacaa gcggaaaaat gacttgttca agtacagagt 3768961 cgtaagggac atttctagtt ttcgatagat cgctaagctg attgcgtaca agctgggtat 3769021 cgacataacc cggacagagc gcattgactg ttatgccgtg gggcgcgcct tccagcgccc 3769081 ctacttttgt gagtccaatg acgccgtgct tggcgctatt ataagcggat ttccctgcaa 3769141 agcccactaa tccattaaca gacgcaatat taatgattct gccaaactgc tgttttttca 3769201 tgatcggaaa aacatgcttc attgcaataa agggagccgt cagcatgacc ttgatcagct 3769261 gttcaaaggt gtctgtcgga aactcttcaa tcggagcgac gtgctgaata ccggcattgt 3769321 tcaccagaat atccaagcgg ccgtattgtt tttggatgac gttcaccgta tcagcaactt 3769381 gcgcttcctt tgtcacatca tacggaatgg ccgccgcgtc aaagccttct tctgcaagct 3769441 tggaggctgc tttttcacat gcttccggac ggaggtctga aacgatgacg ctggcacctt 3769501 cccgggcgaa ttctcttgcg atttcgaatc cgattccgcc ggcagcccct gtcaccaaag 3769561 cgacttgttt tctcatgtca aacaccttcc cattaagaat tgagtacaga ctggcttaca 3769621 gcgaaatcag cttctgtttt ttcataaacc tcttcaattg tgacaccatc ctgaagctcc 3769681 gtcagtgtca tgcggccgtt cacaaaatca aatacagcca aatccgtaat cagcctgtgt 3769741 acgactttct ggcctgtcag cggaagggag catgtttttt tcacctttga ttcaccatgc 3769801 ttattgacgt gctccatgat gacaacgatt cgtttcgccc cgttgacgag atccatggcg 3769861 ccgcccatcc cttttaccat tttgcccggg atcatccaat tggccaaatc cccctgctcc 3769921 gaaacctcca ttccgccgag aatagctaaa tcgatatgcc cgcctcttat catcgcgaat 3769981 gactcagcgc tgtcaaaata agaggcgcct gtcacttcag tgatcgtttc ctttcccgca 3770041 ttgatcaaat ccgcgtcttc cgttccttcc agaggatagg ggccaattcc gagcaagccg 3770101 ttttccgact gaagcatgac gtgaacgcca tcgggtatct catttgcgac aagcgtcggc 3770161 attccaatcc cgagattcac attcatgccg tccttgattt cttgtacagc ccgtttgacc 3770221 attcgttttc tcgcttcctt cacttggcct caccctttcc cgatgcttgc tgaactgttc 3770281 gtttttcaat ccgtttttct tggctcgcgc caagcacgac atgctgtacg taaattcccg 3770341 gcgtatggat gtgatctgga tcgagctctc ctgcttccac gatttcttcc gcctcggcaa 3770401 tcgtgatctt gcctgccatg gcggcaatgg gattgaaatt tctcgccgtt ttcctaaaaa 3770461 tcaaattgcc catggtgtcc gctttccacg ctttgacgat cgccacatcg ccggtaatgc 3770521 ctcgctccag cacataagtc cggccgccga atgttttatg ttcttttccc tcggctatgg 3770581 aggtgccgac gcctgtcgcc gtataaaatc ccggtatgcc tgcaccgcct gcacgaattc 3770641 tctcagcgag cgttccttgg ggaacaagct ctacctcaag ctctccgctt aaaaactgcc 3770701 gctcaaaaat tttattttca ccgacatagg aagcgatcat tttcttgatt tgcttgttag 3770761 ccagaagcaa accaagcccc cagtcatcga ctccgcagtt attgctgaca acggttaaat 3770821 cctttactcc ctgatctctt atagacaaaa tgagctgttc agggatgccg cacagcccaa 3770881 accctcccgc gatcagcgta tccccatcat gaatcagttt cgcagcttcc ttgcttgatg 3770941 acagcacttt tcccatattg atgccccttt cgttttcttc tacactagac cagtcaggct 3771001 gtaaatcgcg atcacagcaa atacggcagc cgttttaatg agcgtgatcg caaaaatatc 3771061 gcgataggat tgccggtggg tcaaacccgt cacggccaga agcgtgataa cggcgccatt 3771121 atgcggcagt gtatccatcc cgcctgatgc cattgaaatg acccgatgca tcacctctgg 3771181 cggaatattg taagcctgaa tcgcctgtaa gtattgttct gacatcgcgc ttaacgcaat 3771241 gcccattcct cccgaagccg agccggtgat tcccgccagc gcagttgtcg taacggcgcc 3771301 atttacaagc ggatcggtaa aagtatgtga aattccgctg ctcagcttat gaaaccccgg 3771361 cagcgcggcg ataatgccgc cgaacccgta ctcagcaccc gtattcatag atgccagcaa 3771421 ggcgccgcca attccttcat tcagcccttc cttcaattgg gcaaacacac ttctccaatc 3771481 aaataatatc gttgtgatga tgccaatcac taaagcaatc tccaccgacc aaatagcagc 3771541 cgctgaagaa atatcaagcc tgccgaactc ctttaatcct atggaagaaa aatcaaatcc 3771601 attcggatac cactttggca ggtaaatggt gaaatattta ttcactgcac cgacgagaat 3771661 aagcgggaca aaggcaagcg cgtgccgaat cgggcttttg tccggttcag ccgcggactc 3771721 aatcgattca ggagcaggag cattctgcga atcaaaaccg ccatagcctt cgccagatgc 3771781 ctgcgctttc ttccgccttg attccaaata gagcatccca gctgccagca caatcactgc 3771841 gcccatcaaa cccagccaag gggcggcata aatgtctgtt ttgaaaaacg acgtcgggat 3771901 gacattttgg atttgcggcg ttcccggaag tgcgtccatc gtaaacgtaa aagctcctaa 3771961 agcaatcgta cccgggatga ggcgttttgg tatgtttgct tcttggaaca tgtttttcgc 3772021 aaaaggatat acagcaaata cgacaacaaa caggctgaca ccgctgtacg tcaagacagc 3772081 acccatcagc acaatggcaa gtatcgctct ttttgccccg acaagccgga caattgtttt 3772141 cgcgattgat gccgcaagcc cggccatttc aacgaccttt ccaaaaatag caccgagcaa 3772201 aaacactggg aaatacagct taataaaacc cgccatcttc tccataaaaa ttgatgaaaa 3772261 aaaaggaagc acatggcttg gatctgtcag cagcaccgcg aataacgcgc aaatcggcgc 3772321 aaacaatatg acagaaaatc cccgatacgc cgtaaacatc agcaaaccta acgccaatag 3772381 aatgatgatc agttccacac acacatcccc cgtttccgcg aactagaaag cgtttacaaa 3772441 aacctgtccg catcggctgt ttccgtcccc tttccatatg tacgagaagc gtgggccaac 3772501 tattccgatt aaaaaaggaa agctcctttt ttcggagctt tcctctacca ttcatttcat 3772561 tcctattagg atatcaacat caaccgtaat atcggctgat ttcatctctt tcagcaggct 3772621 gactcgatct ttcggcgccg accaggcaag cggcgtcatc ttgagaagcc agtggatcgc 3772681 ctgctggtca agcgttttaa catagcgcag cctgacagga cggctgtgtg ctgcatttgc 3772741 tgtaaaacgc tcaactgctg ccgtattgga atacgtgcgc cttggtgaat cagtatataa 3772801 aaattgcctt aattctatta aatagtcgct tcgcggcact acttttatga gcatgccatc 3772861 attcttcagc agtctatgaa actctgcata attggacggc gaaaaaatag acagaacaac 3772921 atcaaattgg cgatcatgaa aaggagcacg cgccacatcg gcaaccgccc acatcagatc 3772981 tttgaatgcc ttagaagctt ttaagatccc gtccttcgaa agatctatgc cggttcctat 3773041 cgctgctttc cctgcataat caaacccgca aagcgcattc aaatgagaac cctcaccgca 3773101 accgctgtcc aagatggtga atgcctcatg accagatttg ggatgactga tgagctctgc 3773161 aatcgcatca tggagcgggt caaaaaaacc acattctcca atcagcctgc tcctcgcttc 3773221 aaaaagctcg gcaccgtaac tggttttgac cggcttcgtc agaaagttca cgtagccgtg 3773281 ccgagataga tcaaatgtat gtcctcgttc tgtacaaatc aagcttttcc ctgatgccgc 3773341 atccatagaa gaatcgcaga gcgggcatcg aaacatgctg aaatcaactg ttcgcttcat 3773401 gataaaaaac accccattca ttcattttta gataaatgaa aaaggcatag acaaataaac 3773461 ctaggcctat ctcaaaaatt ggccaggtct ggcagtttgt ctacacctgt cattatctat 3773521 aacgaatgaa ttggataatc atgaaaaaaa ctccctttct gctgtatggg tttccccgtt 3773581 tccatcatac aacaaatatc caggagctgg aaccttatag tgaagaaaaa tcagtactga 3773641 catgctggta tcccgccaac atcatatcag catagcaatc cagcatgttt ttcctttatt 3773701 ttctcatttt agaatataaa ttttattatt gtgaaaatag ttaaaaaggt tgattttcaa 3773761 aaagtgaaag gataaaatac tgctatcatc ttagaaaaag acattcttgt atatgatcag 3773821 taatatggtc tgattgtttc tacctagtaa ccgtaaaaaa ctagactaca agaaagtttg 3773881 aataaatttg aacgagttga aaaggacaag ttcttttctg tttgctctta tttttcacac 3773941 tttctgcact tccagaattt gtgaaggata agagcttttt ttgtttccat aataaccctc 3774001 ataggagttg ctatcatgta ctttttacta aaccttgtcg gtctcattgt gattatggca 3774061 gttgtattcc tatgttctcc gcagaaaaag aaaatcaagt ggcgcccgat cattacgtta 3774121 attgttctgg aattgctgat tacttggttt atgctgggaa caaaagtcgg aagctgggcc 3774181 atcggtaaaa tcggtgattt cttcacttgg ctgattgctt gcgccagtga cggtatcgcg 3774241 tttgcctttc cgtcagtgat ggcgaatgaa acagtagact ttttctttag tgcgcttctt 3774301 ccaattatct ttatcgtcac attctttgat attttaacgt atttcggcat tttgccttgg 3774361 ctgattgata aaatcggatg ggtgatttca aaggcttccc gcttgccgaa attagaaagc 3774421 tttttctcta ttcaaatgat gttccttgga aataccgaag cacttgcggt catccgccag 3774481 cagcttacgg ttttaagcaa caaccgcctg ctcacattcg gtttaatgag catgagcagc 3774541 atcagcggct ccattatcgg atcttatctt tcaatggtgc ctgcgacata cgtgtttaca 3774601 gccattcctt tgaactgctt aaacgcgctg attatcgcaa acctgctgaa tcctgttcac 3774661 gtgccggagg atgaagatat catctataca ccgcctaaag aagagaagaa agactttttc 3774721 tctacgattt ctaacagtat gcttgtcggc atgaacatgg ttatcgttat tttggcaatg 3774781 gtgatcggat atgtcgcatt aacgtcagca gttaatggca ttcttggcgt tttcgtacat 3774841 ggcctgacca tccagacaat ttttgcttat ctgttcagtc cgttcgcatt cctgcttgga 3774901 ctgccagtgc acgatgcgat gtatgttgct cagctgatgg gcatgaaatt agcaacgaac 3774961 gagtttgttg cgatgcttga cttgaaaaac aatctcaaat cccttccgcc tcacaccgtt 3775021 gcggtggcga cgacattcct gacgtccttt gcaaacttca gtactgtcgg catgatttac 3775081 ggcacgtaca attcgatcct tgacggagaa aagtcaacgg tcatcgggag aaacgtgtgg 3775141 aaactgctcg tcagcggaat tgcggtatct ttattaagtg ctgcgattgt cggcctgttt 3775201 gtgtggtaga aacattgagc catatccctt ttcggatatg gctcttttca ttattgataa 3775261 atagaggctg gcacctgcac atcccggatt cccgctgcat aaggccccaa gtcatactgg 3775321 ccgaagacga tggcgatccc gtttgccgta aagtaaaaca ttgtgtctct gtttagggtt 3775381 atatcctctt tctttacatc agagaaaaac agcacatcgt gttttttgat atagctatat 3775441 aggtaatctc tcgttttgct gacttttgtt ttggtgttca gaatctgatc cagcgtcacc 3775501 cgcttttgtg ctttcaagtc atagttgaag gactggacag acgttagacc gtgggcgccc 3775561 cctgaataga tataattgag tgtttgaatg ctgagcttgc ctgccgcatt gtatttgacg 3775621 ctgaaggatg tttgatattc ccgttttaaa gccctgctgt tcgcctgctt ttttgttttt 3775681 caggtattcc tgatacgatt gttcatgtag gctttcagct cttgattgat tttcttttca 3775741 aacgcggcat tcccgacgtg atgcacttgt ggatacgtta actccttgat ctttttgtac 3775801 gtatgggtgc tgacagtcgg tgttttcgct tgaactgctt ttaaagatgg ggccgcatat 3775861 gcaaatacag aaaaaagcaa gactgcaatg cccgcggctt tcagcatgtt attccatttc 3775921 atacaatcta ctcctttgat gtcgttgttt atcattccct tatttaagca atacacactt 3775981 ttatagactg attaaatcga aagaagtttc taggtctaac agcatgattt ttccaataaa 3776041 aaaagagaca caggatgtct ctttttttac tgtttgcgcc cagaaatcgc ttcatgaagg 3776101 gcttgtgcca aatctgtatt tccgaacatc tctaataccg caatgacagt ctggtccgga 3776161 atgtgctctg cttcgtgttt tggcacgacc agatcgtcca tggttttttt caagctttca 3776221 ttcagctttt gctgcggata cgctttggcg tacagctcca tcggatcaag atcatggttc 3776281 acgcaccact gggcaaacac caaaatcatc atattttcat cgcgttcgta agcttcagtg 3776341 agctgttttt cgttcatttg tcatgctcct tatgaaaagt atcttcctta aagatacagg 3776401 agccgatcaa attcgtctat cccaatggcg atgagcagca accgcatcga taaatgcctt 3776461 gctgaaagcg gtgtagtcag gttcatcttt agccgttacg atgcctagcc cctctgttgt 3776521 cccgacagag gattgaagaa ggtcaattcc ttcatttgcc gcaccgatcg ccttgtagtg 3776581 attgtaagct tctctgataa acgccatcgc ttgtttgttg tcttttaact ccagtcctcc 3776641 tgcggcatag acggcatcat acagaacaga atcaaccgtc aggaacgtgc cgctggcctc 3776701 aagctgctgt ccgctgccgc ttgtcatata ccccagattt tgactgatga tatccactgt 3776761 gattccttct tgctttaagg cttccagtac tgtttgcagc tctttttcat gaaatccgtt 3776821 tccggcgagt acagcgactt ttcttgttga cgcggttttc actgtacggg cttggcttaa 3776881 cgcaggcgaa gtaagaattt ctttagatgc tttacgcttc gcgggcgccg ccacgcctac 3776941 tcctttggcg atttcttctg ctaaatctgc atcgacattg ctgaagacat caacgacctg 3777001 ccgctgtacg tctttgcttt tgaccttccc gacctcgaag cagaaagcag aaatgatgtg 3777061 ctgtttctcc acaggagaca tgctgttcca gaaaagcttc gcctgtgagt aataatcgtt 3777121 gaagctgtcg cttcgctggc ggattttttt gccctcgact ttttcctgat agtggacgta 3777181 gccgccttct tcagctgtcg caggcgacgg atcattgttt tgcagtgagt ttttatgata 3777241 agcgacaggt cccttattga tcgtcatccg gtgatagccg tcgtattggt tgttatggaa 3777301 tggacagacc ggccggttaa tcggaatctc atggaagttc gggccgccaa gacggatgag 3777361 ctgtgtatcc gtataagaga aaagccgccc ctgcaatagc gggtcattgg taaaatcgat 3777421 gcccggcacg acatttcccg ggtggaatgc gacttgttct gtttccgcaa acacattatc 3777481 ctgattgcgg ttcagcgtca tttttccaat gatcttcacc ggcacaagct cttccggcca 3777541 cagcttagtt gggtcaagaa tatcaaaatc aaacttgaat tcatcttcct catcaatcat 3777601 ctgcacgccg agctcgtatt caaccttgcc gccgttttca attgtttccc acaggtcacg 3777661 gcggtggaaa tctggatctt tcccggcaat tttttgcgct tcatcccata cgagagaatg 3777721 cacgccgagc accggcttcc agtgaaattt cacgaaacgt gcctttcctt gttcattgac 3777781 aaaacggaac gtgtgaacgc cgaagccttc catcattctg tagctgcgcg ggatgcctct 3777841 gtcagacatc gtccacatca ccatgtgggc agactcaggg ttattggcga caaaatccca 3777901 aaatgtatcg tgagcagtcg cagcctgagg catttcattg tgtggctcag gcttaaacgc 3777961 gtgaaccaaa tccggaaatt tgattgcgtc ctgaatgaaa aacaccggaa tgttatttcc 3778021 cacaaggtca tagtttcctt cttcagtata aaattttgtc gcaaagcctc tggcatcccg 3778081 caccgtgtct gcggagcctt tagaacccgc aaccgtagaa aaacggacaa ataccggtgt 3778141 cttcaccgaa gggtcctgaa gaaatttggc ccgtgtgtat tccgtcattg gttcgtaaac 3778201 ctgaaaaaag ccatgcacgc caaatccgcg cgcatgcaca acgcgctccg gaatcctctc 3778261 atggtcaaag tgcgtcattt tctcccggaa atgaaaatcc tccatcagcg tcgggccgcg 3778321 aaccccggct tttaacgagt gctcatcctc tgacactcgc aagccttggt ttgtcgtcat 3778381 tttcttcccg ctgttatcgg tcctgtactg ctcaagctgc tcgtcctttg agtgttcatt 3778441 tacacgtttg ttttggtcat cactcatgtc tgctccccct ttttaaaacg aaacattcta 3778501 cagcacattt acccgtggcg ttcttcatat aaactgctaa tccgctcatt aggatttttg 3778561 gtctacatat aaatatgcgg tcatacacat ttgaaataag ccttcttcac agaaagaaag 3778621 gatggaagcg cttaccaaaa aagctgttga ataggggagg tcatatcatg cttgccatac 3778681 tcggttttgt gatgatgatt gtctttatgt accttattat gtctaaccgg ctttccgctc 3778741 ttattgcttt gattgtcgtt cctattgtgt ttgccctgat cagcggattt ggcaaagatc 3778801 tcggcgagat gatgattcag ggcgttacag acctcgcccc taccggtatc atgctgttat 3778861 tcgccatcct gtatttcggc attatgattg actcaggcct gtttgatcct ctcattgcca 3778921 aaatcttatc gtttgtcaaa ggagatccgt taaaaatcgc cgtaggcaca gcggttctga 3778981 ccatgaccat ttcgctggac ggagatggga caacaaccta tatgattacc attgcagcga 3779041 tgctgcctct ctacaaacgg ctcggcatga accgtttggt gttagcggga atagcgatgc 3779101 ttggttcggg ggttatgaat attatcccgt ggggcgggcc gactgcgagg gttttggctt 3779161 ccttaaaatt ggacacgtca gaggtcttta caccgctgat tcccgctatg atcgccggca 3779221 ttctctgggt gatcgccgtt gcttatatcc tcggaaagaa agagcggaag cggctcggcg 3779281 tcatttcgat tgatcacgca ccgtcttccg acccggaggc cgcaccgctc aagcgtcccg 3779341 ctcttcaatg gtttaacctg ctgctgactg tcgctctgat ggccgcactg atcaccagcc 3779401 tgctgccgct ccctgttctt tttatgactg cgttcgccgt tgccttgatg gttaactatc 3779461 caaatgtcaa agagcagcag aaacgaatct cggcgcatgc gggtaatgcg ttaaacgttg 3779521 tctcaatggt gtttgctgcg ggcatattca caggcattct ctccggcaca aaaatggtgg 3779581 atgccatggc gcattctctc gtttcactca tccctgatgc catgggcccg cacctgccgt 3779641 tgatcactgc gatcgtcagc atgcccttca cctttttcat gtcgaatgac gccttttact 3779701 tcggtgtcct tcccatcatc gccgaagccg cttccgctta cggaatagac gccgctgaaa 3779761 tcgggagggc ctccttgctg gggcagcctg tgcatctgct cagcccgctt gtgccttcca 3779821 cctatctatt ggtaggaatg gcaggcgtca gctttggcga ccatcaaaaa ttcactatta 3779881 aatgggccgt gggaacaacg attgtgatga ccattgcggc gcttttgatt gggattattt 3779941 ctttctaaat gtatgagctt gatcgtagca ttgagtgagt acgtgattta cagaggggag 3780001 aagatcaaat aggatattat gagtgaatag aagattcatg ccaacaactt ctcattacaa 3780061 tcataagagc ctgctatatt gcagcaggct ctttcacatt tggcattatt tttttgtata 3780121 gcgcacccag tcataatgag cgtatagcgg atttacacca ttgtaggagc caagccattc 3780181 atcgacaccc gtgccattcc acaagttcat catgatcttt ccaggtgttg tcggaatttg 3780241 gtttgttgca gtatgtttta attgcccgtc gacataccat ttaatagagt ttggctgcca 3780301 atcgaatgca tacgtatgat aggcattggc tgcatcaaac ccgagatcaa caatcttctc 3780361 atggtttcct gcaccatttg tataatagtt aaattgaacc ttcgttgtgt cttttcctaa 3780421 aaattcgata tcaatctcat cccaaggagt tccatctgtt ggacctgtgt aagtgaagaa 3780481 cgatgaaacg atccctgtgt ttttagctgg tttcattctg acttcataaa gtccatagcc 3780541 atatgtttga acagaacggt tttccccgca gtcaaacttg ttataagctg ggcttgttag 3780601 cgctaaacgc atttcaccca atgacgtcat tgatacgtta ttagcccgcc acgtgcagtt 3780661 gaacatattt ccattcgaat aaccatctgc tttttgccaa aaaccggagt tatagccgtt 3780721 aaaagggtca aaaaacgatc cacctgtttg agctgaggca gtagcagtga ctgcaaacaa 3780781 actcataaac aatccagtga caagaagcag caacactcgt ttcagataag gcatattggc 3780841 attccccttt cattgaaagc gttttctatg ttgatcttac atgattcttt taaaagggaa 3780901 catcggtcaa aataatgata atatcgaatc ttactaactt gaatcctgta actatcatca 3780961 tcttccctct gaaaaaaata aaaacctaaa ttaccatcag cacagacaga gatgatccgc 3781021 actcattgca atttaggttt tgcctgcttt atcagtaaca atcctaccat tttcatatgt 3781081 gaatgtaaga aaaagtgaac acaaggaaac acaaatgtca gcgctctcat tatgcttgtt 3781141 taactaccct ttctatgtga atggttaaat acagcagctc gtcacttgtg agcttgtgct 3781201 catactcccg ctcaatgtag gtttggattt tcttcgtgca ttcatacgcg cgatgatact 3781261 tttctttcac tgtatccagc aaaaaatcgt cctggctttc catgtgagtg ccgttaaata 3781321 gacgctgcgc gaaaaacttt aagtgggtga cgaaccgata atagtgaagc gattcttcgt 3781381 tgaattcaat cttaaaatgg tattttacaa tactcaaaat ctcttgcatg acttttgtaa 3781441 tgttgataat attgggcatc tcttcattca gctcggcatt tacaatatgc agagcaataa 3781501 agcctgcttc atcctctggc agagacacac cagtcttgtt ttttaccata accaacgctt 3781561 ctttgccgat cgcaaattcg tctttgtaga gccgttttgt ttcccacagc aaggcgtttt 3781621 tgatatcaag ccctttctgg ttgcgctgga tggcaaagtt aatatggtcg gtcagcgaca 3781681 catagatgct gtcgttgagc tttttgccga gctgtaattt tgcgtagctg ataatctctt 3781741 cggatacttc catacactcg atcggtatat catacaaaag ggttttgaac ttttctgata 3781801 catccttgtt atcgagcgtg aacactttct caatgcgggc ttcatcgaca tcatcgccgg 3781861 actttttctg aaacgcgagc cccctgccca tgacgaccaa ttctttcccc tgttcattga 3781921 ccacgctgat cacattattg ttgatcacct tcgcaatttt catggcatgt ccctccaaat 3781981 ctactaagaa cagactatat cttgattgta cattcttttt gtactaggtc aatatcatca 3782041 gggaaagacg gaagctggtc agtacaattc actccgtacc tgctgcccgg gctgtttttg 3782101 aagcagcgcc tccagatggc gttcaaatga tgccttgtca gctttctgct ttttgacaat 3782161 gctgttcatg attttaatgc tttcagcact gtattgtgta tattgttttt tcagctgatc 3782221 cagctgctgt cttgtcttct tcgcgttttt cggtgtgact tggttgatga gtttgatcat 3782281 actgtctgcg gtctcaaaaa aaccggctct attttctgtc agctgctgaa tttcgatgcg 3782341 gctcatatct tgattacgcg ttttttgaag caaggcaacc gcctcgctgt tttgtttttt 3782401 gagcgatttg ttctcaagct taatcgattc gagattctcc ttcgcaatgt ctgcttcttc 3782461 ttcagtcatg ctgattcgca cgaagtattc tggattgccg attccataat caaatgcttc 3782521 gctcacttgt atcatggaac tgaacacaat ggccagctgc ctgtcgcttg cgagggcttg 3782581 gaaatcctgc tttttcttac tgctcatcgg tttggctgcg gtttgtttta ctgtcttttg 3782641 atcacagtct gcgaacatct gagcctcacc ttcactttcg catgcgctca tcacaagaac 3782701 tgtgaccagc aggcttatac acaagcctat tcgcctcatg ctctgtctcc tctctgctga 3782761 atcccttctg gaaaatacca taaaatatag ttaaatggta ccagatgcac ctaaccccag 3782821 caataaatca aaagtatgat ttgaagcgaa aaaacataaa tattttgtaa aaattgacgt 3782881 gcattccatt cttttcaggc ccatttctcg tacaatagaa gtatcgttac cggagagggg 3782941 ctctgatgat gaaacgtttt acgaaacaag aaaacagctg ggtgttatat gactgggcaa 3783001 attcagctta ctcaattgtc gtgaccaccg cggtatttcc gttattttat aaatcagcag 3783061 ctgcggaaag cggtgtcagc gccgctcaat cgactgccta tctgggctat accattgcga 3783121 tttcaacgtt tattcttgcg atgctcggcc ctattttagg cacaatcgcc gactatgaag 3783181 ggtgcaagaa aaagttcttc ggtttctttg tgtcagccgg tgtcgccagc accgcgatgc 3783241 tcgcctttat ccctagtgaa cattggctgc tattgttgct gttttatacg gtatcggcta 3783301 tcggtttttc cggcgccaat gtgttttatg atgcctttct cgtggacgtc acgcctgaga 3783361 agcggatgaa tctcgtctcg gcacggggtt ttggcttagg atacattgga agcacgattc 3783421 catttatcat cagtattgct gtcatcctgc tcgcacaagc agagactatt ccagtgtctg 3783481 tatcggccgc aagccagctg tccttcttca taacggctgc ctggtggggg ctgttcacca 3783541 tcccaatgat taaacatgtc catcaacgct attacatcaa aaaagaacct catattgtca 3783601 tcaacagctt taagcggctc ggccaaacga tgaaacggat caggcaatac cgggcacttt 3783661 tcctcttctt gctcgcttat ttcttttata tcgacggagt cggcacgatt attacgatgt 3783721 cgacatccta tggatcagat ttagggatcg gctcctcaag ccttctgatc atcctatttg 3783781 tcacccaggt agtcgccgcg ccgttttcga ttatatacgg aaaactggca gaacgcttca 3783841 cggggaagac catgctgtac gtcgggatcg tcatttatat gatcgtctgc gtgtatgcct 3783901 attttatgga gacaacgctt gatttctgga tactggctat gcttgtcgcc acctcgcaag 3783961 gcggtattca agccctaagc cgttcctatt tcgccaagct tgtgccaaag cgccacgcca 3784021 atgaattctt tggcttctac aacatttttg gaaaattcgc ctcaattatg gggccgctgc 3784081 tcattgccgt taccgcccag ctgaccggta aatcctcgac tgcggtgttc agcctgatca 3784141 ttttgtttgt gattggtatt gtgattcttg cctttgttcc cgaggaaacc agcacagatg 3784201 tcagccagca gcaaaatgac ctgccccttt aactgggagc aggtcattca tcatttattc 3784261 gctttattca ccttcagctg tttccctttg acggttgtgt tcttcatcac tttgagaaca 3784321 tgagggcctt taccatttaa aatctcaacg tatgaggcgt tatccatgat cgtgatgatg 3784381 ccgatgtcgt cagctgacac accgtcaatt ttggcaatcg ttcctacaaa atcaacggct 3784441 ctgattttct ttttctttcc gccgttaaaa tacagcttca taatgtcttt attcagctct 3784501 tcgcttttgt cctttttgct ttccggacgg tcattcagtt tagctagaaa ttctggtttc 3784561 ttccttgcca cttcctcttg agaaggtgct tctatttttt ggatttcaaa tccgatatat 3784621 tcttcaatgt cggctaaaaa ccgtttttcg aaggccgtga caaacgaaat ggcctttcct 3784681 ttgttccctg cgcgtcccgt tcggcccgtg cggtggacat agctttcttt ttcaagcggc 3784741 agatcatagt tgatgacaag ggagatattt tcaatatcaa tcccgcgcgc ggcgacatcc 3784801 gtcgccacta agtaacggta ctcgccacgt ttaaattcat tcatgacgtc gaatcggtct 3784861 tcctgaatca ttccgccgtg aattttatcg catggatatc ccaagtcatc caattcatcg 3784921 gtcagctgat tgacgtgctc cttcgttcgg cagaaaatga tgcagctgtc gggattctcc 3784981 gtcatcagca catctttcag caatgaaaac ttattctctt ctcttacttg aatcaccgca 3785041 tgttcaatat ttcttgtggt taggccggcc gctttgacct cgatatgctc ggggttttgc 3785101 atatattgac ggctcagctt ctcgatatcc tgcggaagcg tcgctgaaaa cagcatcgtc 3785161 gtacgctcag tcggcagatg cttgataatc gcctccacct gctcaatgaa gcccatattc 3785221 agcatctcat ccgcttcatc aatgaccaaa taagagagac gatccaacgg cagcgtgcct 3785281 ttttcgatat gatccagaac acgtcccggc gtgccgacaa caatgtggct tttttgctta 3785341 agctcagctt tttgtttatc aaaggaggat tttccaaata cggctgtcgc tttgatccgt 3785401 ttaaatcgtc cgatgttcgt gatatcttcc tttacttgca ccgcaagctc acgggtcggt 3785461 gttaaaataa gcgcctgcgg cttgttttca tcccaattcg ccagctcaca gagaggaatc 3785521 ccgaacgaag ccgttttccc gcttcctgtc tgtgatttga cgacaagatc ctttcgttca 3785581 agggcagcgg ggatcacact ctgctgcacc ttggtcggtt ctgtatatcc cagtccttcc 3785641 aatgctcgta aaatgtcatg actgatttga tagtttttaa aatgactcat gtataaactc 3785701 ctgtctcttg cagatgttct cattatactc taattgacca aggcatatgt gttttgtcga 3785761 aaaatgatgt attaaaagcc agcgattccc tggcgtttta gctcctgaac agccaatcgc 3785821 gccagtgcgt cggcccccgc gcgattcggg tgcagcgtat ctccatccat ataaagcccg 3785881 agtgttcttt ccggaccgat cgatgtaaag tatgccgagc tgaggacatt taagtcaatg 3785941 agatatgttt tttcctcttc ggccaaagct aaaatagagg ccctgtacca tctgtttaca 3786001 gacgaatgga tgccttcaga agtaaaatcg gttgcccggc cctgaggcgt tgataggatg 3786061 acgtccgctc ctttcgcttt tacctgacga atcatatcac gcatcacctc tttaaactcc 3786121 gcttcagatt ctttatgctt cggatttgtg tcattaatgc caagctgcaa cataaaataa 3786181 tctccgggtt taatatactt cagaatcgcc tcaagctgtc catcatttct gaaccctctc 3786241 gcgatctgcc cgccagacgc catgtttctc acttgaaagg tgtgtttatc gatatagtga 3786301 ggcagcatct gcccccagcc cgcctgcttg ctgctgttga gcggataata attgcacacc 3786361 gtcgagtcgc cgccgacata aatggttcga ttcgttaccg gctgatcaga caatttcttt 3786421 attttcaagg cgctgagcgt aaaagcggtg cctgcctttc cctctgtcac cagcagattc 3786481 agctgcccgt cggtgacggg aatttggaac gtatcctccg cgccatcccc tgtcatattg 3786541 atgacctgaa acacgccctc cgctgccaca ctggcccttg ccgtattgcc aagcgtcacc 3786601 ttcacctcat aaaggccatt cgggagatca acattaaacg tgttattgct tttcgtccca 3786661 tacgctaaaa actgaaccgc atcactcttc acaccagccc cggatgccgc cacatccctc 3786721 atattctccg gtgtttgaaa accgtagccc tttgaccggt cataccgatc agacgccctg 3786781 acaccaatat aaccaggctc catcgaaccg cttccaaagt caaactgata caccttcggc 3786841 tccgccgcct tcacattctc aatcccgcca aaacacagca tcagcatcat cacaaaaacc 3786901 gctgccatcc attttttcat caagactccc cctctatgaa aacgaataca ttaatgcata 3786961 ctcggtgatt gtttctttat gatgactgaa ttaagaaaaa aattgcgttg aggaataaaa 3787021 atgaggggag agtctcaaga aggggaaaat cagtgtgact tcttgtcaca cttgatcaca 3787081 tcccaacctc cgcaatagaa gcttatttgg ttttcttcgt catacacata ataacggagt 3787141 ctttcccatt gatcgtcagt cggtacaatc tccaatgcaa ccgaatcgat ggattcaagg 3787201 tcatccagct ttgatgcact aatgttttca aaccgcaatt gaatgtcaca ggtttgagca 3787261 gatcgttttc attcaaacac aggaatatga atataacgat catcttcttt catatagaaa 3787321 gaaaactcgt ttaatgtaaa tggacctgta tcctcatcag aaagatgctg tttcaatttc 3787381 tcgtattgtg tgatattcaa atgaattccc tctatttata tgattcaccg ccaatcatat 3787441 aaatgtccac agcatcgtat tcaaaccata tgatccgttc gcctgagtcc gttaggcatt 3787501 ggagcttccc ttctgaaaaa tagcttttat ccggttgagg atcagtgatc agaaaaacat 3787561 catcattgat ggaagctagc agaaagagaa aatctgcaat atcccggtct gcttcctgta 3787621 atatggattg gaaatggaat tcccttttgg ccagcttcgt caccttgtaa gcatgacctt 3787681 caaaatactc ggacaggtct tctataaatg aaccagtcgt tattacctgt atcatgattc 3787741 gatcgtaggc aagccctgcc caaaaacgat aaaacgactc tgcatcttca agttcgcatg 3787801 ccataacggt ttggtcaggc ttaagctcga tcatgtccaa attgccaata ctgcttatag 3787861 aggttatttc cataaaatct tccccttatc agttggatag cgcaacgcaa atctcttgtc 3787921 tgacttgttc atacaagaga atgtgatgat acagatcctt atcgtttttg atcatatccg 3787981 gaagtatgtc aggatacagc tcaaaaaagc ttttctccaa cgaacgccgc tgatgccggg 3788041 gtatcctttt attcgccagc acataatcca aactgccagc aacaagcata aaaaactcat 3788101 agatttccgc ttcaaagccg tacaattcat cagggtactg cttttcttca agctctcgct 3788161 gtctttttct cagtttttga agcacgttga tcctctccct tccgcaataa tctcatttat 3788221 ttcgaaacag aataggcgga tcattatcta tcgcctccaa cagctcttca ccaaacacag 3788281 tgattgcaca tttccacggg tctcccaaaa gtccccagga gaagtcctga tgaaaaaaga 3788341 aataatagtc tccatttgga aatacgggaa caggccattc gccaaattca tccttaggca 3788401 ttgcctgatg aggactaaag gtatatccgt catgctgcca atctagtgcg tacattacat 3788461 cgttctttcc agtacctaat tgaaatgctt ttaaaataga agtctctaaa tcacttagca 3788521 ctccgctcac atcattatga ccagctttac tgctcatcgc gcttgagata tcaaacactc 3788581 gatatggatc aggcgggatg atgtgatgac atctgcttcc gggcttccat tttatgatct 3788641 tgttcacttc tgaccagatg cggtcttgtt ttgtctgact taaagcgcgc caattcatca 3788701 taatctcatc cctacacctt attggatatc ctgcttataa acaccagaag aggccactgc 3788761 gtaaacagcg taacttgtca gtttcagctg ttgaacatct aggccttcac cgttcgaatc 3788821 acagcatgtt atctcttcca tctcttgact cacatcggca gaaatcaaat aaagagacga 3788881 cttaaggtct gcactgtaac aattgaacgt cccaaccaaa aaaccttctt cggatatcgc 3788941 gagctgatca aatgcttctg agtccggctc tttatccgac agaatccaca cccgtctcac 3789001 gaccgtttca tcaaatgcgg caatgactgc atctccgtaa tacagcatat aaatcaagcc 3789061 gtttttttct gcaagtccat aacaatcatc tacagcaggc gcatccattt cttcaagctt 3789121 tctatcaatg tgtatttcct tctgctgacc atctaacgta aaacaccaca cactatggcc 3789181 gttgggattc tcatcatgat aaatcccttc atcacataaa ccgacccaaa gctgttgttt 3789241 ctaatccaaa agacagcagg aaacccctga aggcaagtga aaaacacttt tcacccttcc 3789301 ctcttctgaa aaaaccttta ccttcggctc gtacgattcg taataaacga agacatagcc 3789361 atctgcacat tgttgaaaga gcagaatatc actgtatgaa atctgctctt tcactctaaa 3789421 atcccgaaca tcaccggaag gatcatagat tgtaatggtg ataccacctt tcaacccttt 3789481 tccaatgtag acacgcccct gtggatcagc atggaaaaaa caatcttggg tgttctcgtt 3789541 gatgatttta ttcaatttta attttttcat tggttatgct cctaggttcg aaatgaaatg 3789601 ataagaataa accatttatt agctattagt aacggacaac ctagtttcat taatcgtttt 3789661 gggataaatc tactttccaa ttcagcctta aatcatttag tgtttaattg gtatgcataa 3789721 aacgattgat catcaaagcg aactgtttca gcttctatag caatcagcat tctgttcatg 3789781 tcaataagaa agttagcatt tgattgatac tccggaatta tagaatttga tagattcccg 3789841 attccttctg gatgataact catctcaaat acttgccaat tgtattcttc cggatctatt 3789901 ttttccaatc tcatgtcgcc aacatctgca ctataataag cggatgccac attttgaaat 3789961 gaaattttat gcgtatattc accttcatct tcaaaaacct taatatcaag tgagagttct 3790021 tttttaaaca cattaaaatc taaatgaagg acactgcacc ccttatctat ataatcaacc 3790081 cattcattaa tcgtttgata cattgtcatc ccctgcctct ttttaaacaa taacgccttg 3790141 ccaccaagca gaaaacaaat tactccgtat attgtttgat ccaatcattt aaatcatctg 3790201 ttgaatgcaa ataagtttct gatgaatctt tcaaatcaat cccacttaga aggattaaca 3790261 tatcccagac tctatcgtct tctacttcgg ggtcatccgc ataaacataa gttccagccc 3790321 aatccgacac ttcttctctt gttgtttgtc catttaagac acttttgatt ttatttatgc 3790381 attctattag atttgtctcg ctcaatttga tcaccacgta ttcaagtact aaatgatttt 3790441 ttattagtat gcaaagcacc gtactgatat ttagatattg aagctttttc cgtaaaagat 3790501 atgttccaaa aggtttccaa tctaccaata aacaagctca catccgtatt ccgtgtgcaa 3790561 tatacataaa ccaaactggc acttaggctc aaccaaaata aaactatgat tgagaatccc 3790621 ttcatcgaac tcaatacact ccaataagca gtcaaggtgc tcgagacatt ttccaaaaga 3790681 acaaactaac gcaccaattt cgctgctgta ttgatgaaac agcagaacgt cccggtcatc 3790741 gtaagcaaca tatgactgag atattttcca gatcagctgt ttcgcttccg ttttttcgag 3790801 ggcatcaacc tcacgggtgt tggctggtat tgaatttgat aaaaccagct caagcaattg 3790861 cctgctttgc gccagatcag caaaacgata agtgaagcct ctttctgcac aagggactag 3790921 tttttctttg atttcgctca tcaataaacg tcttttattc tcggcgagtt tttcgatcaa 3790981 tcttttttgc atgagccgca ttccctccgc tgtcaatttc tcaacttctt ttaaattgat 3791041 tcatcattct cttgttttcg ttgtcgttca tgtttagatt tgttctaaaa aagcttgtat 3791101 cgcttatcga tacaagcttt atcttcaact gcttaaaact cacccagtgg gcttttcaca 3791161 aaacgctggg aacctttttg gcaaatcctc ttcatcccaa tcaattctat atttttagat 3791221 tcttttgtca tacaaataag agaggatggt aacatctctt atttaatgtt ccatcaataa 3791281 atgccccatt tttatccaat gcagaaatta tttataatta aggaagttta gaaggatttt 3791341 ttgtattttc aagatttaat tttaaagcgg tcacaaaaga ctctagcttt tcttcattac 3791401 aattaatttc gaacaagttg gagttcgact tactttcttt ataatcatca aatataattt 3791461 taatcttaat tctgtaattt ccgttttctt gatcaatact aagaaataag aatggttcaa 3791521 tagtctctaa actgatactg tcttgatttc cttttatcat agtttcgatc ccagatatca 3791581 acaccttata ttcactttct aataaaacag cagaaaaatc gcgaacgacg gctttcttat 3791641 tttccaacaa ttcaaataca gataaaataa atggatcatc gtccaactct tgataccttc 3791701 tcggtgttaa ttcaagttct atacaatcat cttttatttt ggccatattt cctcctcatt 3791761 taaagtttaa gtgagggtag ttgtcatccc cccctcgctt aaccttatta acgccttctc 3791821 ttagatttat ttccttttcc gtgtgtatgg aatacgtgtt tagaaccctt agctcttgaa 3791881 cttccataag ctgtgattac tttacccctt ttatttaaaa caactgtagc tttttttcca 3791941 acatatttcg ttgccccatt aggttgtttt attacttttt tagggcttcg cacagcattc 3792001 agtttggccc ttaaattgac tccacggcct ccatttcttc ctatagattg attaagtcca 3792061 tgtcttgtat gacctgtgat tttaactgcc ttcttcgtaa acttataggc gcgactagca 3792121 cccttaaata tcttcccagg accaaaatta gaagcagctg cccaagcagc acctttccat 3792181 cctttacctg atttatatgc cttatatcca tcataggctg caaatccggc atttaccaca 3792241 agccataccc aatgcccgtc cggatcaaca ttcatcactg ggttattatt tccataagca 3792301 tacccattct gatccaatga atctccgtcg ctgcccgggt ctgggtcgag cgataggaac 3792361 acgccgtttc ttggctcgta gtagcgggcc atgagatagt acaggccggt ttcttcgtcg 3792421 tattggtagc ctgcgtagcg gtagcgattg tcttttactt cgtcgcttgc ttcggttttt 3792481 gttggatttc cccatgcgtc gtattgatac ttggcaacgg tttttccagt gctgtctgag 3792541 atcgcgatga tgtcgccgtg agcgttgtag tgatagaaat atttcttacc attttctgtg 3792601 taggataaca gctggccgct gtctccgtac gtgtatgatt ttgtgacgtt gttgtccgcg 3792661 tctgtttcat acaagacgtt caagctgtct ccgtcgtaga agtagttcgt gacttttccg 3792721 ttgacggttt tttggattct gtttcctttt tcgtcatact tatatgttgc gaatggcttg 3792781 tcttcgcctt ttttggtaac ggcggtcagg ttatcttctg catcccacgt atatgtgaat 3792841 ttgccgtcgg atgtgcggtt gccgttttta tcgtaagaga tgctttcatc attgactttt 3792901 gtcagctggt tcatgatgtt gaaggaagcg ttcaccgttt tgcttgagcc gtcttttata 3792961 gttgtaacgg ttttccggtt tccgaatcca tcatatgtgt attcaataac agtaccgtct 3793021 tcatgggttt ctttgacaag ctgattcagc ttcccatact catattgcac cttgccgctt 3793081 gctgagctgt ttatcgttgt gcggttgccg ttggcatcat attcatagct ttccgtcaga 3793141 atgtctccgc cgtttttgtc accgatatgc agcgagctta caaggtttct ttcgtcatat 3793201 gaaaaacttg ttccgccgcc gttgcccgta ataaaggttt ggacgtttcc attttcatca 3793261 taatcaaatg aatatgagga tgtactgtct ttcatctcaa tcatttgatc cagcttgtta 3793321 tacgtaaatt gattcgttcc tttttggtcc ccatgaatcc acgagaaggt tttcagctta 3793381 tcggagtcac taggatatgt ccaagtttgg ctgccgccgc ggtctgtcag ttcggttaaa 3793441 cggtttttgt tgtcaaatgt ccgtttcttt gtggtgttct gctctttatt gacgaccgac 3793501 gtttcatttc catttttgtc atacgtgaaa atgtactttt ctgtaccgtt atacgacttt 3793561 gatttcaccc ggtctgttcc atcataagaa agagacactt cgttgccatt tggtgaaatg 3793621 gttttggtca ggttgctgtt ggcatcatat tcgcttgcta acacattgcc gagagggtca 3793681 gttgttttga caagcttgcc catgacatca tattcgaatt tataggtttg atctgctcct 3793741 gcccggatgg ttttgcttac ctcattgcct tccttatcat agctgtgaag gatagacgtg 3793801 ccgttagaga gcgtcatgtt tgtcaattgg tctgcctgat catacgtata ggttgttttt 3793861 tcaccttttg catctgtttc agacgttttc ttaccagttt catcgtaatc agttgaagtg 3793921 gcgtaaccta gttcgtcctc ttccttggtc acatagttgc cattactgtc atacgtgctt 3793981 ttagtcagaa ggcttccttc aatcaaacgg atatcatcaa accagactgt gcctgtcgca 3794041 ctcttttgga acagaatact gatatcgact ttattgatcg gctttgtttt agggatgacg 3794101 acagctgctc ggttccattc ctgtgttcca gaagggaatt tcgcattgta gatgcctgtg 3794161 ctgccgtcag cgtaagtgac attcgcctgc agagaatagt ctttttcatc tgtaaatttg 3794221 acgctgcttg ctttcgacat tcctgtcagt gtgagataaa ccggtttgtc atttgcgctt 3794281 tgccctaaga caacggtttg ttttgttact gatccggctt gggacgcact ggtccgggca 3794341 gcttttaatg atacatcatc attaaagcct tcttcagaat caacggatgc tccgcttaca 3794401 ttccagtttt ccgttgctga tgtgaagctg ctgttttgaa ctgggttata gcttgatgat 3794461 acttcgcctt tttccagctg gacttcatca aaccatgctt ttcctttgcc atctttatct 3794521 ttatgatcga cttccatata cacaacagct ttgcctgcat tcgctggagt cgtaaaagtg 3794581 atttgccgtt ttgtccagtc attttttccg gctaatgcac tgtattcatt gtgaatccat 3794641 tgaattcgtt tttgatcttt gtctcgcaaa tcaatgttaa aataggctct tgatttcgca 3794701 agatctgttt tgattttccc gcttaatgta taggttgtat tcggctccag ctcaactgtt 3794761 tgtgttgctg acgaataccc atgatctgtt ccggcagacg ttgattggct caagacctcc 3794821 aatgcctttg atccggaaag aactccgctt ttatcggcga tgactgaaat tttgccgctg 3794881 tctttagagg cagtcagatt ccagccggat ttttgagctt caaagcttcc atctttcaaa 3794941 atattagttg aagctgataa atctttgctc gattgaatct ggtttccata tttatcataa 3795001 acagctgctg acgatgattt tccgctctga tcggtttcgg atacagcatc cagtccgtca 3795061 taagcaatat ccgtgacatt gccctcggta tccttcatct ttgtgacatc gttgtttttg 3795121 ttgtattcgt atgtctcagt tccatatgca tctttaaccg acgtaacgtt gccatctttg 3795181 tcatattgat agctttccgt tgcttttccg gtgccgacgt catttggatc tacatcttct 3795241 acaacattgt tgccttcata ctttgtattc gttgtaattt ttaacccttc cgcatcatca 3795301 atgacctgaa tcggatttcc cgcttcatta tagccatact gtactttccg gccatttggc 3795361 tgtgtcatga gaagcgtctt tttatcagca tcatagctgt agacatatgt ttctttttta 3795421 gcgttgatcg ctttttcgag acggtgaccg ctatactgat attcggtaaa gacaggcttt 3795481 gcttcggtac tgttagctga atattgtttg acaaggcgcc cttcactatc gtagtcatag 3795541 cttgtgacag tcccgtctgt atctgtaacc ttcttcagca aatcattctc atatgagtag 3795601 gtgactttct tattcttagg tcctgtgatg gacgtcacat ggccgttttc atcataggta 3795661 aatgtaagct tgcggcctga tgcatctgta atggcggtca gttgattttt gtcattgtaa 3795721 gtatagacag ttgcattgtt atggccatcc actacctttt ggagtttgcc gcctttttta 3795781 ttgaaataag cgttggtttg atcctttgtt tttaatatga actgatcagc tgtttctgtt 3795841 aattcaagat atacaccggt cggcggctga tacgtgccat cggctttttt cgtgaatcga 3795901 tgtgtcgtag cgtcttcatc gatatacatt gccccgccat ccgttgagat gacagatgtt 3795961 tctgcatcag cataccagcc ttgtccaaat aagtgatcag agctgtcaag actgttgtag 3796021 gttctcgata agccaagtcc cggaccgcgt ccatcaattg acaaatcttc ttcattcaca 3796081 atgacattgc ctgtcgcacc atttaactgg ccgcttggga tatcaatgat agaccagtac 3796141 tcttctgtac ctaggaattc tgcgccttca tggaacgttg ggttaaaggg cgccgttgga 3796201 atcgtttcac cattcgcatc ataggcgaca agcgtgaaag aataattctt cttccctttg 3796261 taattcccat ttgcattgtt atagacaggt gatggatcga gggctaattc cccgcctttt 3796321 ccatctgtat gaagcttata gcttccggct ttgatttcct cagaagtcgg ccagatgttt 3796381 ttattttggg ttgtccaatg atcagcatca ccaacatcaa aggactgata ttctttaccg 3796441 ttgtaaatgt taactttata gcccttcgca ttttgaacct tttcccatat caaattcaca 3796501 taacccgttt gactcgattt tgtatttgta tacaaatagc cagttacatt ctttggccta 3796561 gcgatatcag gaagtgccgg ggtagcagcc ggggatgcaa tggcttcgcc gtctttgttg 3796621 tatgcgataa ttttaaacga gtaatttctt ttggctccat ctcccccggc gtttttatag 3796681 gttggtccgg gattgatcgg cagctctgct ccgcttccgt cctttaggtg aagagcatat 3796741 tttcccgcct tgatttctgc acttgtcggc cagatctttt tcccttttgt ggtccaagac 3796801 gtctgatttc cgagatcaag tgtctcaaag cctttcccat tgaacacctg aaccttatag 3796861 ccggttgcac cggatacagc tttccaagaa aggtcgaagt atcctgtggc attcccatta 3796921 ttgtagccct ttgctgacgg tgcttgtgct tttcctacat tagggataac gggctttgcc 3796981 ggtgcggaca tcgctccttc accttggtca aatatcgcac tgacgccaat ccaatagttt 3797041 ttgcttgtag catagcttcc gccggaattc ttatagaccg gggatggatc taatgccaat 3797101 tcagctccat ccttgccgtc cagatgcagt ttatatctct tggaggcaat ttctgcgctc 3797161 gtaggccaga tttttttacc ttttgtgctc cacgacgtga cgttgcctgc agaaatcgct 3797221 tgatattcct taccattgta aatccatacc ttatatcctt ttgcgccttc aacctttttc 3797281 cagctgatat cgaaataacc agtggaatcg ccgttgtgat aggctttgat tgtaggtgtg 3797341 tttccctttg gaatggtata cgtcacttca atatatggtt tattggcgga gttcgctgaa 3797401 gaaattagtt ttttccaata ttccttgccg tttccgtttg tatgaagctt aaatccatag 3797461 ttggccccgc cggagttcca tgactttaca gcagcggtca catcataact cgcccactgt 3797521 cctttatgga cgtcggcttt tccgatattt ttagatgccg gtttggtgtt ccatgtcact 3797581 tttgcattat cataattgct gttgaccgta tccagccaaa ggccggttgc ctttgttcca 3797641 taataggaat gggctacgta tgtttttaat gtagctttag tgacagtcat attttgaatt 3797701 ggctttaggt tgttaaattt catgaacgca tagtttgtgc ctgttgtttt gtcataatag 3797761 cccgttttca gtacataggc ctttaaatta gcatcccatt tttgtgagga ggccgaatag 3797821 ttcgtcgtcg ggtaggcact catgacaaac gtatccgatg aaacagataa agaagttgac 3797881 gggtcgatag atactggata tacgcgttct gggtctttca gccagttctc gtctgccgta 3797941 agatgaagca aatacccttc ttcattcttt tccagcttat agctgacttt gtctgaccgt 3798001 tcaacctcgc cggaaagctc atctagtttt gaatccgtca taaaaggctt aggcacagaa 3798061 aaaacaactt ttcctttttc atcagaaaaa tcaatggatc catcctcttg ttctttagcc 3798121 tgcaaatcgg tttttaactg aaatgtaaat gtgttgtatc cattatactg atgaaggact 3798181 aaatcttctt ttatgttttc attgaatgtg aaagtctgaa gatcaatatt cggaaacaca 3798241 tccggataca caatctcatt actgtcagtc ttataatctg ctgaggtatc tttcggagta 3798301 agtgaagttt tattcgggcc tttcgcttct gctagtgaat atgtaacctt atggtcatta 3798361 tgctcaaaag tcgcataaag cccgttcttc atttgctttt gaaaatctga attcaaaata 3798421 gcgttctctg tctcgacttg tttgcttgtc gactctttta actcaggaga aatgtcttcc 3798481 cagtcggcat ccggtgtttc ctttgtatga ataggatcaa ggtatacttc ctgtttatag 3798541 acaccgtcac cttcataata gagttttgta ttttctgttc tttcagaggt gatctcaccc 3798601 tctttgttta tatcttttgg atcaaaaggt acagcttcct cagtttgttc tttctgaaga 3798661 gtttcttctg gatcatcggc agcaatacgg tttccattct cttcttctgt agattttgct 3798721 agtacatcgg ctggcactaa tgaaatcatt aaagccaaca ctaaaaatgc tgcaatgaac 3798781 cttttaaagt ttcgcctctt tctttttttc atttcctctc tccttttgta ataaaagtaa 3798841 tatttactca ataatcttaa ctagactgaa atatcattac aatatttttc tagaaaattt 3798901 atcttatttt aaggattagc gagagtcaat tgacctaaaa caaaaaaagg ccgcataggc 3798961 ctttttacat tttttattgt atttgttcaa tatccgtacc ctcagctgtc acattcgcct 3799021 tcccctgcct cctgacaagc gtcaaggcca tgcccgcaaa gatcattacg atgccaagcg 3799081 tttgatagag gtcagggcgg aagcctgtga agacggtatc gagcacgatc gcgacagcgg 3799141 ggtcgagaaa tacaatgatt gaaataaatt tcgttgataa aaatcgtaaa ctgtcaaaaa 3799201 acagcaaata tacaataccc gtatggatga tgccggtaga taccaccata atccagtttc 3799261 cctgagatag gtccgcaaaa gcgccaaagt gaataaacgg aatcaggatg ataaccccta 3799321 aacctgtctg caagaaggtg gtcgtgtaag gactgagatt gtgaatgcct tttcccaata 3799381 aagtggtgaa cgcataaaac agtgcggcga gaactgccca tatgatccct gatcccatca 3799441 gctgtgtcaa tgatgtgctg ccgttaatcc cggaaatcag cgcagtccca agaaagcaga 3799501 tgataatgga gctgacggag atcacattta atttctctct gtagaagaag ctccccagaa 3799561 gaagaacaag caccggcgct agatgataaa cagagatggc aattgtaacg gacgtttctt 3799621 caaaagactt aaataagaac acccagttga atacaagaaa gaaaccgcac gccaatgttt 3799681 gcagcacgtc tctcttgctc catttttcag ttttatactg gccggacgcc agccagcaaa 3799741 agcctaaaaa cagcgtcgcg caaaggcagc ggacaaagac caattcaaat gacggcagat 3799801 tggtatgctc tgagaaaaag ccgatggagc cgaaaatcac catagagatg accattttga 3799861 ttacggctgt tgatttttgt tttgacgata tggaaggatc ctgttgcatc aaacgtattc 3799921 tacctccaat actgcatagc ataaactgtt ttttgtgaat tcagaaatct acacatagaa 3799981 ttcctctttt ttacatgtag atattataac acttctattc taaataaaaa aaagcgccca 3800041 agggcgcttt ttttacaaat ctatcgaaca atcaaaaccg ggcatgttga taattgagac 3800101 actttatggc tgacgcttcc aagcatcatt tctttcaggc cgctgatccc ccggctgcca 3800161 actacaatca ggctgacgcc tttctctttt gcgtgattta gtatctcatg cgccggctcg 3800221 ccattcgcgt aaatggtttc agcttgaacg cctttttcgg ctgctttttc ttttgcattc 3800281 tcaaggattt tcaggccctc ttttttaacc tcgttcctga tttcatcaat aaagtgttca 3800341 ggcacataga caattcccgt cagagaagaa gtcgtgacga cggcttctct ccccacatga 3800401 agaatgctta gttccgcttg ttgctctttt gccaaatgca ctgcggcatc aagcgctttt 3800461 gcactcatgt ctgatccgtc aatcgctact aacattttgt taaacatgct cttcccgcct 3800521 ttcggactgt gggtggttca tctttctctt ttattgtccg cctgcatttc gttattgtca 3800581 attgaagcgc atgagttttc aaaaaattgt cagagactct ctccgtttgt ggcgataacc 3800641 tgctgatacc agttgaagct ttttttcttg atgcggttaa atgttccatt tccttcattg 3800701 tcccggtcta cataaatgaa gccgtagcgc tttttcattt ccgcagtaga tgcgctgaca 3800761 aggtcaattg gcccccatga tgtgtatccg attaattcaa cgccgtccgc aatggcttcg 3800821 cgcgcttcaa ttaaatgatc acgcagatag ttgattctgt aatcgtcctg aatcgtgccg 3800881 tcctcttcaa ccttgtctac agcgccaagg ccgttttcaa cgatgaacag cggcttctgg 3800941 taacggtcgt ataaggtgtt gagcgtgatg cgcaagcctt tcggatcaat ctgccagccc 3801001 cattctgatg atttgaggta agggtttttg actccgccca gcaggttgcc ccctgatttt 3801061 gcaagctctt ccggatctgt gctcgccgcc atcgacatgt agtagctaaa tccaatataa 3801121 tccaccgtat gttctttcaa gagctcttca tcgccttcag ccatttcaat ttcaatattg 3801181 ttttctgcca gatagcgttt catatatccc gggtatgcgc ctcttgcctg aacatctgag 3801241 aagaaaagtg ttttgcgctc attctccatt gccgcgaaga catcctccgg cttagaagtc 3801301 atcggatagg ttgtcgttgc cgctatcata cagccgattt tcgaatcagg aatgatgtcg 3801361 tgacccgctt tgacagcaag agcactggcc acaaattggt ggtgtgccgc ctggtacatc 3801421 gcgtttaatt tgttttctcc ttcttcaaaa acaagaccgc ctccggtaaa tggcgcatgg 3801481 agcactacgt taatttcatt aaacgtcatc caatacttca ctttgtgttg atagcgtttg 3801541 aaaaccgttt tggcatagcg ttcataaaac tctatgactt tgcgattctt ccagccgcca 3801601 taatttttca ctaaaccgag cggcatctca taatgagaga tggttacgac aggctcaata 3801661 tgatgcttta acagctcatc aaacagatca tcataaaatc tgaggccttc ttcattgggc 3801721 tcctcttcat cgccattcgg aaaaattctc gtccacgcaa tcgatgtgcg gaacgcctta 3801781 aatcccattt ctgcaaataa ggcgatatcc tctttataac gatgataaaa gtcaatcccg 3801841 ttgtgataca gattcaagga agtcattgat tcatcaaatg gagacatgat cccgttcggc 3801901 gatacgtcag ctgtcgaaag ccccttacca ccctcgttat aagcaccctc cacttggttg 3801961 gcagcaactg cgccgcccca taaaaatcct tctggaaatc gtttttcatt tgaactcata 3802021 ttgatcaccc cattagtttt ttcaagataa agcaagcagc gcttcttttg gctgcacttt 3802081 accgatctct ttcaccggcg aaaacgaata ttggtctgtg ttggtcacaa tcaccggggt 3802141 aatgacgtca tatcccgcgg ctttgatttg ctccagatca aaggacacga gcggatctcc 3802201 cggtgcgacc ttgtcgcctt ctttgatgtg agccgtgaac cattgtccct ccagctttac 3802261 cgtgtccaat ccaatgtgta tgagtatttc agctccctga tcactcgtaa tgccaattgc 3802321 gtgttttgtt ttaaaaatgg tggtaacgct tccacgaaca ggcgaaacaa cttctccttc 3802381 ttcaggctca atggcaaatc cttttcccat gaccccagca gaaaacactc cgtctttgac 3802441 ttcacttaag gctttcactt ctcccttaat cgggctgtga atgatctctc tgctgccttc 3802501 atgcactgcc ggctgctggc tgccgtcaga aggcacatcc tcgaatccaa gcaaatacgc 3802561 agctgctgtt cccgccgcaa acgcaatcac aaggccgatc atcgcgtaaa taaacgttgg 3802621 gccgataaag acagggatgc tcggcagacc tgcattcccc ccgacgatat aggaagcaac 3802681 acccgtcatg ccgtaaaacg cgccaccggc tgcaccgcca atcaaagcgg ccgcaaacgg 3802741 ctttttcaat cgcatattca cgccgtacat cgcaggttct gtgatcccca tcagcgccgt 3802801 gatgcttgtg gtaagcgcga gtgatttaaa ttttttgttt ctagagcgaa ggaagacggc 3802861 aaatgatgct cccgcctgcc ccatattcgc caaaaacata gccggcagta aataatcgtg 3802921 gccgttttga gcgatgttgt tgatcatgat cggcacaaag gcatagtgca tgcccgtcat 3802981 aatgattaaa gagaatgtac ccgccagcaa aatcattgcc acaagccctg catgatcaaa 3803041 caaataattg accccagaag acaagtattc tcctaaaata gcgccaagcg gaccgactgt 3803101 aatcaatgtc agcggcacga caatcaatag cgtgaatgtc ggaaccacaa tcaatttgag 3803161 agatgcgtgt gtaaaacggt caatccattt ttccacgtat gaagcaatcc aaatcgacag 3803221 caaaatcggg atgaccgttg acgaataagt ggcagcggtt acaggaagcc cgataaagga 3803281 aatcggtttc cccgcaccga gcagggctgt caaatccgga tgcaggatcg ccgccgcaat 3803341 ggcagccgct acgtacggat tgcttccgaa ttttctcgcc gcactcatcg ctagcaggag 3803401 cggcaggaag tagaacgcac cgtcaccgac agccgtcaaa atgacatgaa cctggctctt 3803461 ctccgccatc cagccaaacg tgactgccag cgccacaagt cctttgatca tccccgctcc 3803521 cgcaatcgca ggcagaatag gggtaaacac cccagaaatc acatcaaaga ccgcactcag 3803581 cacattcttt ttctgagagg atgaaccagc gctcttttca tcactgagat tgctgtgccg 3803641 cacaatcgcc tgatacacct tcggcacatc gtttccgata atgatttgaa actgctcgcc 3803701 gctgatattg gtgcccatca ctccaggcag ctgctccagc tgactgcgat ccgccttcgc 3803761 gttgtcatga agattaaaac gcagcctcgt catgcagtgg atcacgcgct gaacgttttc 3803821 ttcaccgcct acgagttgta atatgtcctt cgataattta tcataatcca tgtgtatacc 3803881 tcctttttat ggggggactg ctggatgaaa ggtggccgcc tttcaccagc tttttttgta 3803941 tcaaatgctg catcacctcc taaaagagaa taaaaaaacc taaatgacac agattgcgag 3804001 agtctcctcc tgcacctgca ccatttaggt tttgcctgct ttcgcagtaa caatcctgac 3804061 gggtcgtttt atttgtttgt aggtatactt tagcactaga ttcgtgagat gtcaacgctt 3804121 tcatttttgg tgttgactat cgtttctaga acaaaagtaa tcataaagat ttgaacttag 3804181 tattaacttc aataaaaaat tattgtaatt aaaaaccttg aaaggcattt tttccaatca 3804241 aggttatgaa tcgttaccgt ttaaattttt ttaaagactt ctttatctgt actattacat 3804301 tctttagcca atctattggt tctaaattaa acgcaggaag atacacgcca tctgcgcaag 3804361 attgaatgta atcgtttttc ttattgtctg aatgctcact ttcaataaaa tccgttaaaa 3804421 agacaatagc atcctccaaa tattccttac tttcctctat taataactct tgtatagcgt 3804481 catcaggagt ttcaatatct tgatggaatg ttccagctaa aaactgaaaa acagggtcct 3804541 tctgtttatt gatcaataac atgtcatctt gctcctttaa gggagaggta acgggataat 3804601 gttaaaatca ttcatcatct aataaatcaa gataatactg atcattctct tctatttttc 3804661 ttaagaactc ggtaagagaa gttgcaattt gaatatcata atagtaaatc ggatttttat 3804721 tattatcatt taattcaatt gacattaatg ccgattcact accttcaaaa aatattaatt 3804781 tatcattctc aaactcatca tatatttcta tgtcaggata aaattcaaag tcatttatcc 3804841 tcaatcgaaa gtctcttaca gaatatggat ccaaaatgcg attagtatta aactctgatc 3804901 ctttaataaa cccatagcca acttctaaat aaaaattcac taattcacta ggtaatttta 3804961 agtttaaatt tttttcaacc tcttcaatct cactttgatt cactggataa aaatcatttt 3805021 ctttgtttga ttttataaaa ttataactca tttttttttg cctcctttaa ataattcatt 3805081 tgctggtgag cctgtaccat gaatcccagc ttgatgctcg ttaggaaatt ttgctggatg 3805141 catattccac cattcatgtt ctccgccaaa agtattttca attatatggt gagcatcata 3805201 cttatcccct ttttttctaa taattttacc tgttttttca gatacaacat tttccttata 3805261 aacaggccat ttttgtccag tgttttcttc ccattctttt ataactttat tttttacttt 3805321 atcaaattta gtcctgtgtt ttgcagtctc tattggtgac atttttttat attctttatt 3805381 tcttaatgct tcctttaatt tatctatttg atttttaggt aattctctac ctgtgcgttg 3805441 ttctatatct ctagcatact tttttattaa atcagaatta attttattag cagatccact 3805501 tacatcattc gcaattttcc ctttatcctt agcaacgttt ttaacttccg aagccttctt 3805561 agcctttttc ccattattaa taagtttatt aatatctatt aacttttcta acttagctat 3805621 tttggcaaat ggtactgagt ttatggaggc aacaacacgg tctttccctg tgactttttc 3805681 gcctgatacc ggatctctgc ccgtggctgc tttaaataga tcatacacgc cggtaagttc 3805741 tacagccgtc tctaaaattt tcacatatcc attctcatcc actttaatgt ccgaaagcga 3805801 gacgacaggt tcaagcttca tgtcattacc agatatgtat acattgtaaa gtgtatcatt 3805861 ataaacgact tgcttaacct ctgcatttga gaaatcagtt tttatatgtt ctctatgttc 3805921 actcgtatta tacactttac cattgataac gatgatattt ttacttacct ttttagaatc 3805981 acccgttttg acaactgaat ccactttaga cttttcattc tcggctaatt tcttcagcat 3806041 catctccatc ggtgaatcat ccgcctgctt catttgcggg ttaatcgcgc cgaagatttg 3806101 gttgatgttt tcttcttcct gtgatttcag gatggagccg cttttgtagc ctgtgatttc 3806161 aattttcggg ccggtgtaca tggtttcgag ctgatcaatg tattttttca tcgtttgaaa 3806221 atctgatttt gcggcttcta gtgcttgggt ttgctggccg tcaaattgaa agagcttatt 3806281 cagggtgtct gaaatcagcc gctcagcctg ttctgtttcc atccgaaaaa aggaatcatt 3806341 gactgtcggc aggctgacga tgtgatctat ggctgatgtc tggcgattga ctgcgtcagt 3806401 gagctgctct gtcacttctc gtgcatgctt gaccccatgt ctcgcatcgt gtgagagaaa 3806461 agcctctgcg atcatgccgt gggagttaga ttctacagag gaaatcgcat gctgtgtttg 3806521 tttcagcact tttttgtatt cgtcgataaa tatgccaaag aaaaggagaa aaggcttgtg 3806581 gcactcctcg taaaaggtcc ggatggcatc tccgcctttt cctttcagcg catccttcat 3806641 gcctgccaga tgctcaacgc ttttttccag cttctccagc tgttgttttt gcttgtccag 3806701 tttctcaatc gtatgctgaa tgccctcgtg aagagcgtgg acatctaatg ttttcaatcc 3806761 cttgtcctcc cgcgctttat ttcatggaag atgatatgtt ttcgtccgtt tccttcatgg 3806821 cgtttaccgc gctttccgtt tgtgcgatat gcttggccag aacagacgca tatgcttcag 3806881 tgagctcttt gatgtcctta tttaattgct cgatggactt cacaacattc aaatggtttc 3806941 tgcctgagag atgaccgggc aatgaggact tgagttcagc tgaattcttg agctgagaaa 3807001 gcccttgctt cactgtgtca tacaccattt taatttcctg tgccatttgt gctcacctca 3807061 ctttttatgt ttttccttct ctatttcatg ctctatcctc gtgatttggc gtcttataga 3807121 atacacatcg ccctctaatg agtggatttt tccttctatg ctttcgatga ttccgctgac 3807181 ttgatcgctt ttgatttgct gatatgcttt gttcattcct tcacgaatat cttcaaaccg 3807241 ctcagcatgt gttcctctcc atgcctcccg gttaagatga ggccggtgaa tgagatgctg 3807301 ggcctcagag aaatcgtgtt tgatttgcct aatttcgtgc agcactcgtt ttaattgatg 3807361 gatctgttcc tgcttttcat gtaagtcggc ttttaccgaa tgtaacaaca tttcactatg 3807421 catgccgcaa cacctcgtgt ttctatcaaa ctgtgtaaat tctttacaat acagactatt 3807481 ttcatattac atgatgggtc atattggata aataggtaaa aaggattgtc ttgagaggta 3807541 tagaactggt tctaaattgc taaaaatacg atctcatcac cctatgaaag gagaaaacaa 3807601 tcatagtagg gactttttat ttaagccttt aatctctcct ccagttctaa tttttcctcc 3807661 cacttaactg tttcttatag tcaataaagc tcataaaaaa acaccttccc tcgaaggcgc 3807721 ttctccatct tatttagatc cccatacagc ctcaccgctg gtattcagca cactaaacgt 3807781 catgacgttc ttctctctca ccgaatccca ctggcgtaaa aataccccgt tatacttctt 3807841 gcctgctaac gtgatgtcgg cggtgttttt tccggttttc ctccatgttc cggtcatttc 3807901 cccggaaatg gtgtggtttt tgttgagctg gatgttgatg gtttgtttga tgtcggctga 3807961 gatgtctttt ccgtgctgga taagtttgta tgttcctgtg atgtcttttt gttttacttc 3808021 tttcaatgtt tcgcccgcat aacgatatgg tgctgctacc ggccagccgt ctttgttcat 3808081 gaacaattgg tggactctga cttcgtgttc ttcacccctg cccgggaagc gggtgtggaa 3808141 gattaaatag gaacgcccgg ttttttcatc atagtatgcg gagttgtggc ctggtgagac 3808201 gtacccggtg cctttttcat tttctgtttc aaaagtgtag ctgcccatga gtttgacgcc 3808261 gtatggttcg atggaacggt cgtcgaagaa tgtgcctccc ttgccgcgga cgtcgagcat 3808321 tggattgcct tctgcatcat agtaagggcc gtccggtttc ttggagcggg ccacacggat 3808381 gttgtagccg cctgttgcat cgagaccgcc atatgatagg tataagtagt agtattgggt 3808441 gtctggattg tagagaacat acgggccttc gattctgctg tggttgccgc cgagcagttt 3808501 tttcccatat ccctgtccag gaagcgggaa gcccgttttc ggattcattt caagtatgaa 3808561 aatgccgcct gagtatgatc cgtacaccat ccacagcttg ccgtctttat caaagaaggt 3808621 atgcgggtcg acgacattcg gatgtttggt tgcatcatac ggtgttccat cgctgcttgt 3808681 gccttccatt cctgatttca aaaagatgcc tttgtttttg tatgggcctt cgatgttgtc 3808741 agcaacggca acacccatgg cggatcttgg cgaatcgccg cggcaggcgt tgtagtacat 3808801 gtagtatttg ccgtccgcca gctgcgtgac gtcagccgcc caaagagtat cggattgcgc 3808861 ccattcgaag gtttctttta attcttcata gacattcggg ataagtgggt tgtcattgct 3808921 tacgctggtg gtcagctgct gccattgcat gaggtcattc gatttagctg aagcgagatg 3808981 agatccaaaa acataaaaag tgccgtttgt ttcaatgatg gaagggtcat ggacgctgac 3809041 ttctttaaat ataggttttt gtgcatagac ggagtttggg agggtgaagg ccatgataag 3809101 agctgcaaga aaacatacac ggaacaatcg gttgaacatc taaacaattc gcctctcttt 3809161 tttattaaat tttaaacgct tacatttctc tatgaagata ccccggccta ttaaaacagc 3809221 cgaatgtttt catattcatc cagataggtg atttctcact tcacttacat agtcagactg 3809281 atgtctgtct gttttgcgca gaacttgttg cttgcatatc ctctccttca tagttcaact 3809341 cttttgctgt ttctccttct tgcatcacgt ctgtttttct ttcgcgtaca tgtaataact 3809401 gctttgtcag gttttgcatc aactgtgata cagccatttc gttgtcggcg ttttttaaga 3809461 tgatgcctga ttgcccgtca acaccagagt cattcggctg gctctttata aaacgccttg 3809521 cgaaaaatac gacttagtaa acgcatattg agagttagac agcggcgctt gcctccttgt 3809581 ctggatatcg tgtgcaatcg ctgaaaaaac ctgttctgct ttctgcgtca cgctattaca 3809641 atagcaatct aacttgttaa agactataaa aaaacctttt gacttctgct gctgaaccaa 3809701 ttaatataat actcagttaa tagttatcag aatttttagg aattgagtga ttcatatgac 3809761 actgcataaa gagcgtcgga tcggccggct gtctgttctc ctgctgctga atgaggcgga 3809821 agaaagtacg caggttgagg agctggagcg agacggatgg aaggtctgtc ttggcaaggt 3809881 aggatcaatg gacgcacata aagtagtagc cgcaattgaa accgcttcca aaaagagcgg 3809941 tgtcattcaa tctgagggtt atcgggagtc acatgcgctt tatcatgcga cgatggaggc 3810001 tttgcatggc gtgaccagag gtgaaatgct gctgggatcg ctgcttcgga cggtgggatt 3810061 gaggtttgcc gttttgaggg gaaatcctta tgaaagtgaa gcggaaggcg attggatcgc 3810121 tgtctcgctt tacggaacaa tcggggcgcc gattaaaggt cttgagcatg aaacattcgg 3810181 cgttggaatt aatcacatat gaaacagccc atagatctta gacgataggg ggctatgcgt 3810241 gaaaacagaa gttcacagca tagctccttt ttgtatgggc gctttaccaa agtaaagaaa 3810301 aaggagttgg gcttatggtg actttagacg gttcttcatt gacaacagcc gacgtcgctc 3810361 gtgtgctgtt tgattttgag gaggcagcgg cttctgagga aagtatggag cgcgtgaaaa 3810421 aaagcagagc agcagtggaa cggattgtac gcgacgaaaa gacaatctac ggcatcaaca 3810481 ccggatttgg caaattcagc gatgtcctga ttcagaaaga agactcggcg gcgctgcagc 3810541 tgaatttaat cctttctcat gcctgcggag tcggcgaccc ttttcctgag tgtgtttcca 3810601 gggcaatgct gcttttgcgc gccaatgcgc tgttaaaagg cttttccggt gtacgcgctg 3810661 agctgatcga gcagttgctt gcttttttaa ataaacgcgt ccatcctgtc atccctcagc 3810721 aaggatcact tggcgcaagc ggagatctgg cgccgctttc ccacttggcg cttgcgctga 3810781 tcggacaagg agaagtcttt tttgaggggg aaagaatgcc ggcaatgaca ggcttgaaaa 3810841 aagcaggtat tcaaccggta acgctgacat ccaaggaagg gcttgccttg attaacggga 3810901 ctcaggccat gactgcaatg ggggtggtcg cctacatcga agctgagaaa ctagcctatc 3810961 aaacagaacg aattgccagc ttaacgattg aggggttgca gggaattatc gatgcatttg 3811021 acgaggatat tcacttagcc cgcggctatc aggagcagat cgatgtcgca gaacgaattc 3811081 gcttttatct atctgacagc ggcctgacaa cctcccaggg agaactgcgg gtacaggatg 3811141 cctattcatt gcgctgtatt ccgcaagtac acggtgcgac ttggcagaca ctaggatatg 3811201 tcaaagaaaa attagagatt gaaatgaacg cagctacaga caatccactc attttcaatg 3811261 acggtgacaa agtgatttcc ggcggaaact ttcacggaca gccaatcgcc tttgccatgg 3811321 attttctgaa aatcgcaata tcagagcttg cgaatatcgc agagcgtagg atcgaacgac 3811381 ttgtgaatcc gcagctgaat gacctgccgc cgttcctgag ccctcatccc ggtctgcaat 3811441 ccggtgcaat gatcatgcag tacgccgcgg cctcactcgt ttctgaaaat aaaacactgg 3811501 cccatcctgc aagtgtggat tccattccgt catccgccaa ccaagaggac catgtcagca 3811561 tgggaaccat cgccgctcgg catgcttatc aggtgatcgc aaatacaagg agagtcattg 3811621 cgatcgaagc catttgcgca ttgcaggctg ttgaatacag aggcatagaa catgcagcgt 3811681 cctatacgaa acagcttttt caagaaatga gaaaagtcgt gccgtccatt cagcaggacc 3811741 gtgttttttc ctatgacatt gaacgcttga ctgactggct gaagaaagaa tctttaatac 3811801 ctgatcatca gaataaagaa ctaaggggga tgaacatatg actgatgtaa aaaaatcaat 3811861 ccgtgccaac agaggaacag agcttgaatg cttaggatgg gagcaagagg cagtgcttcg 3811921 gatgcttcga aacaaccttg atccagaagt cgccgagaag ccggaggacc tcatcgtata 3811981 tggcgggatt ggcaaagccg cacgggattg ggacgctttt cacgccattg agcattcctt 3812041 gaaaacatta aaaaatgatg aaacattgct cgtgcaatcc ggaaagcccg ttggcatgtt 3812101 ccgtacacac ccgcaggccc ctcgcgtgct cctagcaaat tctgttcttg ttccgaagtg 3812161 ggcagactgg gagcatttcc acgaacttga gaaaaaaggg ttaatgatgt acggacagat 3812221 gacggctggc agctggattt acattggctc acaaggcata ttgcaaggaa cctatgaaac 3812281 cttcgctgag ctggcgcgac agcacttcgg gggcagctta aaaggaacgt tgacgctgac 3812341 agcgggtctc ggcggaatgg gaggcgccca gccgctgtca gtcacgatga atgaaggcgt 3812401 cgtgattgcc gtcgaggttg acgagaaacg catcgacaag cggatcgaaa caaaatactg 3812461 cgatcgaaaa acagcatcga ttgaggaagc cttagcttgg gctgaagagg caaagctggc 3812521 aggaaaacct ttgtccattg cacttctcgg aaacgcagct gaggtgcatc acacactttt 3812581 gaaccgaggc gtcaaaattg atattgtgac agatcagaca tctgcccatg accctttaat 3812641 cggttatgtt cccgagggct attcccttga tgaagctgac cgtttgcgtc aagacactcc 3812701 agagctttac gtgcgccttg cgaagcaaag catgaaaaaa catgtcgaag ccatgctggc 3812761 ctttcagcaa aagggctcta ttgtatttga ctacggcaac aatatccggc aagtcgcaaa 3812821 ggatgaaggg ctggagaatg ccttcgattt tccggggttt gtccctgcct acatccgccc 3812881 cttattctgt gaaggaaaag ggccgttccg ctgggcggcg ctttccggag atccggcaga 3812941 tatttaccgt acggatgcgt tattaaaaga gctgttcccg acaaataaag cccttcaccg 3813001 ctggattgat atggcacagg aaaaagtcac cttccaaggc ttgccgtccc gtatctgctg 3813061 gcttggatat ggagaacgaa aaaagatggg cctcgccatt aacgagctgg ttagaaccgg 3813121 ggagctaaaa gcgcctgtcg ttattgggag agatcatttg gactgcgggt ctgtcgcctc 3813181 tccaaaccgg gaaacagaag cgatgaagga tggaagtgac gctgtcggtg attgggctgt 3813241 gctaaatgcg cttgtcaaca cggcggcggg tgcaagctgg gtttccttcc accatggcgg 3813301 cggcgtcgga atgggctatt cccttcatgc cggcatggtt gcagtggccg atggaagtga 3813361 gctggctgac gagcggctcg cgcgggtctt aacgagcgac ccaggaatgg gcattatccg 3813421 tcatgcggat gcgggttatg aacgtgccgt tgaagtagcg aaggaacagg acattatcgt 3813481 gccgatgcaa aaataaagga gtgatgacat gccaaagcaa attgatacga ttctcatcaa 3813541 catcggtcag cttttgacga tggaaagcag cggtccgcgg gcaggcaaaa gcatgcagga 3813601 tcttcatgtg atcgaagacg ctgttgtcgg catccatgaa cagaaaattg tgttcgccgg 3813661 acaaaaaggg gctgaagccg gttacgaggc agacgaaatc attgactgtt cgggacgcct 3813721 tgtaacgcct ggcctcgttg atccgcacac ccatcttgta tttggcggat ctcgtgaaaa 3813781 ggagatgaac cttaagcttc agggcatttc atatttggat attctggcgc agggcggcgg 3813841 gattctgtct acagtcaagg ataccagggc ggcttcagaa gaagagctgc tgcaaaaagc 3813901 ccattttcat ctgcaaagaa tgctgtccta cggcacaacc acagcagaag tgaaaagcgg 3813961 ctacggcttg gaaaaagaga cagagctcaa acagttgcgt gtcgcaaaga aactgcatga 3814021 aagccagcct gttgaccttg tttccacatt tatgggagcc catgcgattc ctcccgaata 3814081 tcaaaacgat ccagatgatt ttctggatca aatgctttcc cttttgccgg aaatcaaaga 3814141 gcaggagctc gccagctttg ctgatatttt tacagaaaca ggcgttttta cagtcagcca 3814201 atcccgccgt tatttacaaa aagcagctga ggcaggcttc ggattaaaaa tacacgcaga 3814261 tgaaatcgat ccgcttggag gtgctgaatt agcaggtaag ctaaaggccg tctcagccga 3814321 ccatttggta ggtacatcgg acgaaggcat aaagaaattg gctgaggcag gaacgatcgc 3814381 cgtcctcttg ccgggcacga cattttatct tggcaaaagc acatacgcca gggcaagagc 3814441 tatgattgat gaaggtgtat gtgtcagctt ggcaacggat tttaatcctg gcagctcgcc 3814501 gactgaaaat atccagctga ttatgtccat tgccgcgctt catctgaaaa tgactgcaga 3814561 agaaatatgg cacgcggtca cagtcaatgc cgcatatgcc ataggaaaag gagaagaagc 3814621 cggtcagctc aaagctggcc gctcagctga tcttgtcatt tggcaagccc cgaactatat 3814681 gtatattccg tatcactacg gggtcaatca tgtacatcaa gtcatgaaaa atggaacaat 3814741 tgttgtcaac agggagggag ccattcttgg ataagtaccc ttttctcaga gaggccggat 3814801 cttcgtttaa agaccgggat gtcacaaaaa tgagcgacct gatcgcaaca tgggacggcc 3814861 aggacattaa gggaccggcg ttgataggtg tccccctatc aaaatcctcc atcagtcatt 3814921 caggcgcttc ctttgcaccc ggaacaatac gccaggctct gaaacattca tcagcctatt 3814981 ctgctgagct tggagagcac gtcgtatcag agcttctata tgacctgggg gatatcgata 3815041 ttcatgtcac tgatatcgta aagtcacatc atcacatttt ccaaaccatg cacgctctgc 3815101 tttcggatca tccggattgg gtgccgctca tacttggggg agataactct atcagctact 3815161 ccacaataaa agcgatagca caaacaaaag gaacgacagc ggtgattcaa tttgatgccc 3815221 atcacgatgt tcgcaatacg gaggacgggg ggccgacaaa cggcaccccc ttccgccgcc 3815281 ttttggatga agagatcatt gaaggtcaac atttgatcca gctgggtatc agagaattca 3815341 gcaacagcca ggcctatgaa gcatatgcaa aaaaacataa cgtgaacatt cacacgatgg 3815401 acatgatccg ggaaaaagga ctaatcccaa cgataaaaga gattttgcct gttgttcaag 3815461 ataaaacaga tttcattttt atatctgttg acatggatgt cttagaccag tcccatgcac 3815521 ccggctgtcc agcgattggc ccgggcggcc tctatacaga cgaattgctt gaagcagtca 3815581 agtacatcgc acaacagccc aatgttgccg ggattgaaat tgttgaagtc gaccctaccc 3815641 tcgattttcg agatatgaca agcagagctg cagctcatgt tctgttacac gcattaaaag 3815701 gaatgaaact ctccccattc aagtgatctt ctggcaggtt gtattttggg tataagaaac 3815761 tcatctgcct aaggaatggc agctaaaagg agggcgagac agtgaatctt caggagaaca 3815821 gcagccaaca gctaaaacgc acaatgaaaa gcaggcacct atttatgatc tcattgggag 3815881 gcgtcatagg cacaggactt ttcctcagta cgggctatac gctacatcaa gccggacccg 3815941 gcggtacgat actcgcttat gtaatcggcg ggttgatgat gtacctcgtc atgcaatgtc 3816001 tcggcgaatt gtcggttgcc atgccggtga ccggctcttt tcaaaaatat gctacaacat 3816061 ttatcggtcc atctaccggt tttatggtcg gcatcatgta ctggatcaat tgggtggtga 3816121 cggtaggctc tgagtttacc gcatccggta ttctcatgca gcgctggttc cctgacagca 3816181 gtgtatggat gtggagtgcg atttttgcag cccttctttt tatatgcaac gcattttcag 3816241 ttaagttatt tgcggaaact gaattttggt tttccagcgt aaagattgtc accattattt 3816301 tatttatcat tttaggagga gccgccatgt ttggcctgat ctctttaaac ggaacggcgg 3816361 atgctcctat gttgtcaaac ttcacagatc atggcgggtt gtttccaaat ggctttctcg 3816421 ccgtttttat cgcgatgata tctgtgagct tcgccttttc cggtacagag ttaatcggcg 3816481 ttacagcagg agaatcagca aatcctcaaa aggatatacc gcgatccatc cgtaatgtcg 3816541 catggagaac cgtgattttt ttcattggcg ctgtcttcat attatccggg ttgatttcat 3816601 ggaaggacgc aggcgtgatt gaaagcccgt ttgtcgccgt atttgcggag atcggaattc 3816661 cttacgctgc tgatattatg aatttcgtaa tattaacagc cttgctgtct gtcgccaact 3816721 caggcttata tgcttcgacc cgtatgatgt ggtctttagc aaatgaaaac atgatcagct 3816781 cccgttttaa gaaagtgaca tctaaaggca ttcctttaaa tgccttaatg atcagtatgg 3816841 ctgtatcttg tttatctctc gtttccagta tcgtggcccc tggaactgtc tatgtggtga 3816901 tggtcgcaat tgctggattt gcaggagtcg tggtctggat gagcattgcc ttgtcccaac 3816961 tcttgtttcg aaagagattt ttgaaaaaag ggggggatgt aaaagatctg acatttcgca 3817021 cgccgcttta tcctcttatg cctatagccg ctctcttatt atgttctgct tcttgtatcg 3817081 gtcttgcttt tgatcccaat caaagaatcg cacttttctg cggagttcct tgtatcatcc 3817141 tttgctatct catctaccat ttcaaaagaa atgttacaaa agcgaaaaaa atcagccaag 3817201 aggaatatcc agccgatcac atcctataat taaaaaagca caccccgctc agcatgggat 3817261 gtgctttatt ttttattctg taattaacgt atgaatcagc ttcggcgcct tcgcttccgc 3817321 ggcgatgcgg atgttgtcat agacttttgc gatgacttca tcgacgtttt ctcggttagc 3817381 gtaaagcgtt acgagcggtt cccctttttc tactttgtcg ccgacctttt tgcggagcat 3817441 gatgccgacg gctaaatcga tttcgtcttc ttttgtggcg cggccggcac ctaacagcat 3817501 cgccgcgacg ccgatttcgt ccgcgacgat ttcagagacg acacccgctt ctttggcagg 3817561 cacatcaatt tgatatgcgg cttgcggaag cttagacgga tcgtcaacaa ttgagctgtc 3817621 gccgccttgg tttttcagga aatccttgaa tttctcaagt gctttgccgt ttttcatgac 3817681 ttcttccagc ttcgctctcg cttcgtccaa tgtatcggct tttttcgcaa gcacaaccat 3817741 ctggctgccg agcgttaaga caagctcatg aagatcctca ggcccctcgc ctttgagcgt 3817801 gtcgatcgct tctttgactt caagcgcatt tccgatcgca aagccgagtg gctgggacat 3817861 gtctgaaatg acagccattg tttgacggcc gacgttattt ccgatgcgta ccatcgcttt 3817921 ggcaagttca gctgcgtctt cttctgtttt catgaaggcg cccgctcccg tttttacgtc 3817981 aagcacgatg gcgtccgccc cggcagcgat ttttttgctc ataatcgagc ttgcaatgag 3818041 cggaatggaa ttgaccgttc ccgttacatc acgaagcgcg tacagttttt tatcagccgg 3818101 cgttaaattg ccgctttggc cgatgaccgc aaccttgtcg cggttcacaa gtttaataaa 3818161 ttcatccttc gtcagttcca cgtggaagcc catgattgcc tctaacttat caatcgtgcc 3818221 gcccgtatgg ccgaggccgc ggccggacat cttagcaacc ggcacatcaa gagccgcaac 3818281 aagcggagcg agaacgagcg ttgtcgtgtc gccgacgccg ccggtagagt gtttatccac 3818341 tttaattcct tcaatggcag aaagatcaat cgtttcaccg gagttcacca tagccatcgt 3818401 caagtccgcg cgttcacggt cactcatatc ctggaagaaa atcgccatag caagcgcgct 3818461 tgcctgataa tcaggaatgc ttccatctgt atagccgttc acaaaaaatt gaatttcttc 3818521 agtggtgagt tcttttccgt tttgtttttt gatgatgata tctaccattc tcatgtttgg 3818581 tcaccgatcc ttttcgatta agttcagtaa atcaagccca caattgctgc tgataaaaag 3818641 ctgacaagcg tagcaccgta taataatttc aagccgaaac gagcgacgac atttccttgc 3818701 ttttcattca gtccttttac ggcaccggca atgattccga ttgaggagaa gttcgcaaat 3818761 gacacaagga ataccgatac gatcgctgtt gtacggccgc tgaaatggaa accgttttgc 3818821 gtaagcgacg tcatggcgac aaattcattc gataccattt ttgttgccat aatgcttccc 3818881 gcattaacag cttcattcca tgggataccg acaagaaaag cgaatggagc aaacacatat 3818941 ccaagaatgc cttggaacga aataccgaat actgcattaa aaatgccatt gatcaatgca 3819001 ataatcgcga caaatccaat cagcatcgca gcgacgacaa ccgctacttt gaaaccgtca 3819061 agaatgtatt ctccgagcac ttcgaagaag gattgttttt cttcttcctc aacacgaagc 3819121 atatcctctt cttttgcaac ctcgtacgga ttgataatag aagcgataat gaaaccgcca 3819181 aataagttca aaacaagcgc tgttacaaca tattccggtt tcagcattgt catatacgca 3819241 ccgacaatcg acattgatac agttgacatc gcagatgcgc aaagcgtgta caagcgctgc 3819301 tgatttaaaa gaccgagttc tttcttcaag gagataaata cttctgactg ccctaaaatc 3819361 gcagaagcca ctgcgttata cgattccaat cttcccatac cgtttacctt gctgagggca 3819421 aggccgatat atctaatgat aaacgggagg actttccact tttgcagaat cccgatcaga 3819481 gcggaaataa acacgattgg caagagaaca ttcataaaga atgtcgtttg gtccgcattc 3819541 accaagccgc caaacacaaa gttaattccc tctgccgcgt attcaagcag gtaaccgaat 3819601 ccttttgcaa atcctcccac gaggaaattc cctattccgg tattgaggag aatgtagcca 3819661 agaataaatt gcaaaatgag cataacaaca attgggcgga tcttaattct ttttttgccg 3819721 ctgctcgcga tccacgcgag gcctaaaaac acgattaaac cgataatccc aatcaaatac 3819781 ttcatatgtg tttctccttt atttgtattc gcttacaatt actgtttcct cagaaaacgg 3819841 aaagcagtct gccttccgtc agctcttaat agttgtctcc gcctgatgca ttttctcctt 3819901 ttacgataga aacgcctgcg ctggcgccaa ttcggcttgc tccggcctct accattgtgt 3819961 ctacatcttc tttcgttctg acgccgccag atgctttcac gccgatatca ggccctactg 3820021 ttttgcgcat taaggcgata tcttccttcg ttgcgccgcc tgtagaaaag cctgttgatg 3820081 tttttacgaa atccgctccc gcagacaccg ctaaacggca tgcacgttct ttttcttcat 3820141 cagtcagaag gcacgtttcg ataatgactt tgacaagcgc ttttccggct acagcttcca 3820201 ctacaccgcg gatatcagct tccaccacat cgtcttcctt gtcttttaaa gcggcaatat 3820261 taatgaccat atccacttca gtggcgcctt ttgaaatggc gtcttttgtt tcgaacgctt 3820321 ttgtttcagt tgtattggca ccgagcggga agccgatgac cgtacaaacg tcgactccag 3820381 ttcccttaag ctcttttgca gcaagctcca cccatgtcgg attgacacat actgaagcaa 3820441 atttgtatgt tttcgcttct tcaattagtt ttagaatgtc cgctttttgt gtatgcggtt 3820501 tcaaagctgt atgatcaatt atgttggcta atgacatcct tcgcacactt ccttttttgt 3820561 taagatattt tttagcataa ccgacttttg aacatatgta aattggtaat tgaaattttg 3820621 ttcaatgaaa ggtttgaacg tgtcacaaat cattaacaag cgccctcgcg gtatgctggt 3820681 caatgattaa aacgttggca tattttccgg ttaatgctcc gtgaatggaa gatacttttc 3820741 tgcttccgcc ggcaactaaa atggagcgtt ccttcagtct aaggtcttga agctcaacac 3820801 cgatggtccg gtcattgatg gcgctgctgc aaatattccc tttcgcatca aaaaagcgtg 3820861 aacaaatatc cccgacggcc tgttttttca gcagggcttt ctcttcttcg ttaaaatatc 3820921 cgagccgaaa caacagcgct tcatcacgga cagtcccgac cgtaaagaga gcgatattcg 3820981 cctgcttgcc catctcaatg atccgttcaa tatgacggtc tttctccacc attcgcttca 3821041 catccgcatt atcaaacacg acgggaagcg ggagatagcg cggcatcgtt tgaaaagcct 3821101 ctgcaaacag ctgaatcgtt tcagccgaat acgtgtttac ccgggaatgg ctgatgccgc 3821161 ctttcagctg gacgacctcg acgcctttta cctgcttcgg ctgcatgttt tgcgcgattt 3821221 gatacatggt ggttccccag ctgacgccga caatgtcgcc gtcttttacc gtttcatgca 3821281 tatattctgc accatagcgg cttaggtcat gtgtaattcc tgcataatcg ggtgtcgggg 3821341 aaaacacaac atgcgcctca aggagcccgt atttctcttc aagtatggaa ccgagcgcat 3821401 ccaaatcctc aaaagggtcc atgacgcgaa tctggacata ccctttttcc tttgcatatt 3821461 gcagcagccg ggaaacggtt ggccttgaaa tgttgagctg ctcagcaatt tgctgctgac 3821521 tgtagtcaga ctgatagtaa agccttgccg cttctatgct taattgctgt ttttcccgat 3821581 ccattctgca cctccctgtg gatcagtcct gataaaactg cttttgattt gcttttatta 3821641 tacaggctgg cgccggcttt catccacctg atttctaaga aactgaaaaa cgctctgggc 3821701 gcggacctgc ccagagctta cttctcccaa gtcatatgct gataaatgcc tttcataatg 3821761 gcgtacattc catataggat caggcctaat gccaatatag acagaatcaa tttgccatgc 3821821 ggctgctgcg cgagttctgc gagcgcgccg tcaaagcctc ttgtgtcgtc gggatcagcg 3821881 gtcatggctg tcttgatgag aaaatagccg atagccgaga aaataatggc ccgggcgata 3821941 ttgcctgcgc gtcctgtgtt tttcgtgatg catatcatct gtttgttcat ttttgatgta 3822001 tcgaattctt tcataaaagc agcccgaacg cctttcataa attgaacaat cgcaaatacg 3822061 ataaaacccg cacccgtaag ccctgtgagc cattggccga acggctgcgc caatacataa 3822121 gcggaccacg tctgttctga agtgccgccg tccccttggc caaacacaaa tcgcaaggca 3822181 ttccaagcga tggatgtgta aacagcggca ctgaaaaagt ttcctattct ccgcgacagg 3822241 cctcgcctgc tgtttccgtg cccctccgtg tccttgatcg cgcttaacac catccagatc 3822301 acatagccga taaggccgat gcctataaaa aaaagcaata gtgacccata cggcatgcgt 3822361 gatagcgttt ggagagctcc gctcgaatct ttggcgcggc ctgccccggc agccgtcata 3822421 aaagccaaaa ccccaagcag aataaaaacg ccgccgaatg caaaataacc aagcctcccg 3822481 aatcgtttga tccaaggctt ggtttcctgt tttatttttg acatgtaccg gtctttcacc 3822541 gccatgtgtc caaccctctt tcacagaaat ctttactgta acattcccga ttgaacaaag 3822601 ttgaaacagc tcctgcctca gctatggctg gctgagatac gtttttgctg tttagctgat 3822661 tgtgcaggtg tcatccaagc agccgctgcg gcagctgtga ctccgcctgc taatttccca 3822721 atgatcatgg ccgccgccat ttcttttttc attccagcta caaaaccgag atggctgccg 3822781 agtacaaagg cgccgctgac cgcaaacgcg acattgatga cctttcctct cggcgtcata 3822841 tcctttaatg aagccagcat tgggatatga tgcgccaaag aggtcactaa gcctgctgtt 3822901 gctgtctcat ctaaatgaag gcatttcccc agagcctgaa gcggtttttt aaaggttttt 3822961 gtaataaatg ccgtcatcgg gaacgcccct gccagagcaa tggcgatggt ccctgtcgtt 3823021 tgtatccctg tctcgacatt ctccattccc ggaatcagca caatgccggt catcgtttca 3823081 acagaaacag ctgcaagccc gataatcgca accatactga ccgctttccc gaagagatga 3823141 aacaactgaa tcattctgtc ggtgtatcgc cataacccaa aagcgatgac agcagataac 3823201 agactcggga tcagaagatt tttacctatc atgccgatgt caaagcctgc gcataatccg 3823261 ccgattaagc aaccgatcgg cactgtgcac agcccgatta atatgccttt cgcaaaatac 3823321 ggatgatcct ctttttcgat gatgccaaga gcgacgggaa tcgtgaagac gattgccggc 3823381 cccatcattg ttcctaaaaa cacccatgaa aacagcccgg cctgcggatc tttcgccatt 3823441 tctccagcca gcgcatatcc tcccatatca atcgccaaaa tggtgttcgc aaaggaagaa 3823501 ggatccgcgc caatcgctgt gtaaaacgga gcaacaatgg gaatcaagat tgctgccagc 3823561 acgggcgcca gcgatacaat tccgatcatg gacagcgcca gcggccccat agccttaaag 3823621 ccgtccgcaa accgctcgcc tagcccccat ctgtttccca aacaataatc cgctgctccc 3823681 catagtaaaa aggcagccaa aatgaataca accgcgtcat tcaccgtcat ggttttctcc 3823741 tttttcaaac gtatgattgg ttttatcata tcatctgaaa tcaccgaata gagttgatct 3823801 tattcaatat gagctaaaaa ttcttttata tcggcttttt caacggctgt tataatgcgt 3823861 cgcgcttttt cttgcgggac cgttaatgtc aatttttcta ttatgtcttc ttcagacagc 3823921 tcatttcctg gtgccccttt tgggcagtcc acacgcgctt cgcaaatccg gccgtctgat 3823981 aaataggccc ggacaatcgt gaaacggcct tttggaacgg catgaggagc cggctgaata 3824041 gcattgtcat atacgcgctg aattcgcccc attgtcgttt gaaccccgtt tgggatcggc 3824101 tggctgctga aatgttcaac ggtcaggccg tgtccatgca aagcaagagc aatcacatat 3824161 tcaacgctga aacggccttc ctctccagct tttggagatc tttccgtcaa tgcagcatct 3824221 ccgcctggcg gaaatatcac ttcaatacgt tcggtattgg cagcagaaat ggtttcttcg 3824281 gagataagct gtcgtaccgc atctgcagca tggtgtgccg cggaacaaaa tggatagatt 3824341 ttaaaccata gacccggctg cacaattctc cacggtgccc cccaatcgtt tagcaaagtg 3824401 tgttgtgctt tctcaacgtc accgtacaga ctgaagaaac cagtttctcc atcaagtgcc 3824461 gtgcgggacc cgccaaattc tgattgggcc agcttaacgg ccagcaagcc agcctgagcc 3824521 gccaaaccgg cgtgcagcgg tttcatttct gttccaaatt gcaccctcat cccagcagat 3824581 tgcgtagccg caaaaccaat tgctttttcc aactcttcct gagtcagctc ctcagcataa 3824641 cctacggcgc aggcagcagc gatggcacca agcgtacctg tattatgcca gcccttctca 3824701 tagtggcggc tgccaattga ttctcccagc cgtgccatca cttcaacacc aacaacataa 3824761 gcgccaagaa gccgctcgtc atgtccgcga gcggcagaag caataagggc cggtacgatg 3824821 actgcactgg ggtgtcctct tacatcggag tggacatcat caaaatccaa tgcatgggcg 3824881 ataaatccat tgagcatcgc ggattgtaat ggcgcggcct ttttgccctg tccgataaca 3824941 ggaacaaggg gccggcctcc ttcatcctct atcagacgga ggagcttttg aattccttta 3825001 tcttctcttc ctgcgaatga agcggcagta aaatcaagta atcccttttt tgcttcgtga 3825061 atcgcgtcaa ctgaatgctc aggttgtgac gttctcacag cctctgcaag acctgctgtc 3825121 agcccttgtt tgctcatttg atggtctcca atacaataac cgccagctcc gcaaagtatt 3825181 gagaggcaac cgtaagggct tcttcatcca gtgtaaaggc cggatgatgc cactcctccg 3825241 tcccgttcgt tcccatccag acaaaaaatc ccggaatctt ctcttgatac agagcgaagt 3825301 cttctccgcc cggagactgc tcagcgtgaa cggtttgata gccaagccgt gccgcagctt 3825361 cggatgccgc attcaaaaat gtgccgtcat tctgaacgga aggcaaataa ggaaaccact 3825421 tgaattctgc ttgtgcccca tagcccgctg caattccttc agccactcgt ctcatatgct 3825481 cgggaacagc ctgcctcgct tctttttgaa aggttcgaac cgtcccctcc atttcagctt 3825541 ggtctggaat tacgttccac gaggtgcccg cctgtactct tgtgatactg acgactgcgt 3825601 tttgcagtga gctgatattg cggctgacca cagattgcag cccgctgatg atttgtccgg 3825661 ctgcagcgat tggatcaata ctgttatttg ggatgccggc gtgcccgcct ttccctttga 3825721 tgacgatctc aaatcggtca acacttgcca tgagcggacc ttcctttaca ccaatggtcc 3825781 cgacaggcag atccggctta ttgtgcatgc cgaaaatcgc agaaacgcca ttaagtacgc 3825841 cagcttctag aacctttctt gctcctgcgg caatttcttc ggccggctga aagataaagc 3825901 ggactgtacc tttcagctcg gcccttcttt gattcagcaa catcgctgtg ccaataatag 3825961 aagcagtatg aaaatcgtgt ccgcacgcat gcattgtgcc atcaacctta gatgcaaatg 3826021 gaagattcgt ctgttcttgg atcgggagcg cgtcaatgtc cgctcgtatt gctatcacgg 3826081 ggccgtcttc ccgtcctttg atttctgcaa tcacaccagt cttcaattga gggacatcaa 3826141 gtatttcgat ttgctcctcc tcaagccaac ggcggatttt tttcgtcgtt tcaacctctt 3826201 gaaatgacag ttcaggatgt tcatgaagat cacgccgcat attgattaaa cgggtatgaa 3826261 acgctttgtc ggccattgtt cttctcccct tcttatataa gctctgcagg ctctcccacc 3826321 tgcttgataa atcgtttcgt ccgttcgttt ttcggatggt caaacagttc ctctggcgtt 3826381 ccctgctcga taatatggcc gtctgccata aaaatcactt gatcagcaac ctcttttgca 3826441 aacgccattt cgtgtgtaac aatgatcatc gttgtttgtt tttccgcaat ggacttgatg 3826501 acctgaagca cccctgtgac gagctcaggg tcaagcgctg acgttggttc atccagcaaa 3826561 atcgcatgcg gattgaccgc aagcgcccgc gcaatgccga ttcgctgctg ctggccgccg 3826621 gacattgtga ttggatagct gtcagcctta tgctccagac cgacttgttt cagaatctcc 3826681 attccaatac gtttcgcttc gtcgcgtggt ttatgttgag ccacgattaa agcttctgta 3826741 atgttttgca gagccgtttt atttttaaac agattgtagt tttgaaagac catggccgtt 3826801 tgctggcgaa gccgatgtgc ttccttgcgt gtaaactttt ccgcattcag tttggcttct 3826861 ccgatttcaa taaggccttg atccggacgc tctaatagat ttaagcaccg gagaagcgtt 3826921 gattttccgg aaccggacgg accgatgatt gccaccactt ctccgcgttt cacttctaga 3826981 tcgattccgt cgagcacgac gagatcttta aacgctttgc gaatattttt tactgttatc 3827041 aactgatttc acctctaagt ccggtatggc ttgctcatgg cacgttcaaa caagtcctgc 3827101 aaaatgctgt agataatggt aagaacccaa tagacgatcg caaccgccaa atacgtctca 3827161 aaatatttga ggtttcctga agcgtacatc ttcccttggg cgaacatctc catgacccct 3827221 aatgtaaagg ccagtgacgt ttctttcagg agcccgataa atgtattgcc cgttgccgga 3827281 atcgcatttc ggatcgcttg cggcaaaata atccgtctgt atgcctgaaa ttttgtcata 3827341 ccgacagaca ggcacgcctc cagctgcccg tcatcaacag aattgagggc ggcccggaag 3827401 atttctgcca aataagctgc gttttttaag cttaacccga tgatggcagc tgtgagagct 3827461 gtcattttgc tcatctctgg aaatagctgc ggcagcccgt aatagattaa gaacagctgt 3827521 acaagtgtcg gcacgcctcg gaaaaaggat atatacagct ttgacagctg atgaagcact 3827581 ggaattttgt tttttgtaat gagtgcgaga ataagtcctc cgataatggc aaaaatcata 3827641 gctgctattg ccataaacaa ggtgatcgga agggcctgaa ttaaagtcgg gaacgctgat 3827701 atcatgaatt cccaatcaat cgtgttcatt ctggtgagtc accgccgttt cttaatgctt 3827761 ctgttctact gtgatatctt cattaaagta tttttcagag agttttttca gtgttccgtc 3827821 tttacgcaat tcatctaggg ccttattgac ttttttgcgg agcttgtcgt gcgcatcgtc 3827881 cttggcaaat gggaatgcaa cctgttcgta aacaatcgga tctcctgcaa gctttaatgg 3827941 caaaccggtc ttcttgattt gcgcgatcaa tacagttcgg ctgttgacat aagcgtctac 3828001 acggccgtac gcaacatcct tcagcgtacc ctcttgtgtt tcgtacgttt tgatattgat 3828061 ttttttatca ggatctttgc tttcaaggtt tttcgcgtgg tttgaaccga gaacggctgc 3828121 gactgtcttg ccttttaaat cgtctactga tttgatgtct gtattgtctt ttttgacgac 3828181 aatctgtgtt cccgcataag cgtatggttt cgtaaagtta tacgtttcct tacgttcgtc 3828241 tgtcacagct acctggttgg aaatggtgtc aagcttgcct gtttgaagct ctcccatcag 3828301 cccgctgaat tcaagcagct tccagtccag tttcatgtca attttcttag cgactgcttc 3828361 catcacttcc acgtcaaagc ctgtcagctt tccgttttct ttataagcaa atgggtaact 3828421 ttgtcctgtc gcaccgacat gaagcacatt gtcatcctct ttactgctgc tgtttccatt 3828481 gccgcaagct gagagcaccg ctaataatgc agcaacgacc agcactgtcc attttttcat 3828541 cttcatttga ttttcccgcc ttttctattt ttatagatca tgtcgcaatt gttttttcat 3828601 atagactgtg atatgccctt ttccaaggtc ttgttcacct gagcggacat atccttttcg 3828661 ttcgtacatc tcaatcagcc acggatgctt atccgctgtt ccgagtgaga caaacggaac 3828721 ctttaacgta tcgcgaagga ttgtttcctc cagccattga agcagctttg ttccgattcc 3828781 ttttttaccg gtgtcggggt ccacagcaaa ccaccagata tgcggaacgc catacggtcc 3828841 cggctgtttt ccccaaggca ttctcaaggt gatggtcgcg atgatccgcc cgtcttcttc 3828901 catgacgtag caagcatttt cccgaatatt tttcagcacc aaatccaaat ccgcatgagc 3828961 agcagcaaaa cgaatgccga gctttcgaat cggttcataa gcccgcaatg tcagctcgag 3829021 aagctgttcg gcatcacgtt caactgcaag gcggtatcgt ggcttcatct agcgttcctc 3829081 cttactttgc atagcggttt accggctttt ccaaaccgaa gtgctctcgt aatgttgtgc 3829141 cttcatattc ttttctgaac acgccgcgct cctgtaaaat cggaaccact tgatcaacaa 3829201 acacttcaat tccttctgga agaagcggag gcatgatgtt aaacccgtca cacgctttcg 3829261 tatccaccca ttcctgcatc ttgtcggcga gctgctccgg cgtgccgacg aagatatggt 3829321 ggcctctgga gcctgcaacg tatttgtaaa gctctcgtat cgtcatattg tcacgttcag 3829381 ccatctcctg aacaagcttg aagcggctct tcaccgcatt ggaagcttcg gcgtcaagct 3829441 tcggcagcgg cccatcaagc ggatatgccg acaaatcaat tccgcctaag taattttgga 3829501 gaatttgcag accgacagat gggataatca gatcttggag ctccttgtat ttggcttgcg 3829561 ctgcttcttc tgtatcggca atgattggga aaatacccgg cataatggca attttttctg 3829621 gatcacgtcc gaattccgca gcctgttctt taatggattg ataaaattct tgagctgatt 3829681 ccaggtggtt ttgtgctgtg aagatcactt cggctgtttt ggcagccagc gcttttccgt 3829741 ctcctgatga tcctgcctgg ataatgaccg gctggccctg cggggttctt gaaacgttta 3829801 gaggtccgcg aaccgagaaa tattctcctt tgtggttcag ctcatgcatt ttttctttgt 3829861 caaagaattc acccgtttct ttattacgga taaaggcgtc ctcttcccat gaatcccaaa 3829921 gcccctttac aatctcgaca aattcctctg cccgctgata gcgcaaatgg tgttcaaggt 3829981 gcttttcacc gctgaaattc agcgctgttg attcaataga tgaagtgacg acgttccatc 3830041 cggcacggcc attggacaga tgatccaatg acgcaaactg tctggcaata tggaatggct 3830101 cgctgtatgt agtggaggct gttgctgtca gtccgatttt tgatgtgacc tgcgccaaag 3830161 cagagagcag ggtgaatggc tcaaaccttg ttaatacatt tggatgtgat ttgctgtcaa 3830221 ttgaaaggct gtccgctaaa aacagcatat ccagcttgcc tcgctccgct gttttcgcaa 3830281 gctctttaaa ataatccaaa ttcatgctcg catctgacgg cgcgtccggg tgccgccaag 3830341 acgcaacatg atggcctgta cctgctaaaa atacccctaa tttgatttgt ttctttttgc 3830401 ttgtcatggc gatactcctt ttatcatgtt tttaggctga ataatccgaa aaataaactc 3830461 ctatattcct agtcgtttaa tatgaataaa tcaaaatgta cctttgtctt ggacgtttgt 3830521 caatgagtta agattaattt tttctattca agcgaaaaga cccttgcgtg accatgaggg 3830581 aacggcattg attcattcaa ctagtgcaac ctctatatcg gcaagaaaac tgagtctaat 3830641 gaagcaaaga ctcagttttc ttccaataat ttcatataag atttcgccat ttcctttgcc 3830701 ttttcttcgc ttttgcaaac cgcctatcca ttcagacgcc gtaacgattg tataaaaaaa 3830761 cagctgactc cagatattca aaccggaatc agctgattga tgtgaattaa ttaagctcat 3830821 gaatactctc ttctgcttta gcggaaaaca ctttaggctc caaacagtca aggtcttcat 3830881 gaaataaatt tactttttgg atttgccgat tgtcatagtg gtggaaatag tagtttccag 3830941 tttcgttgca catcacggaa gtatattgcg tataatgaat ttcgtcttct tccgttatca 3831001 ctgcgccctt tggtatcgtc atatttgcca aaatttgaaa agcggctgtt acacctttcg 3831061 tttcatcggc cgccggctct agatgttctt tcaaataaac agctctgaca aaccgggaag 3831121 gcggtgtata atcccccggc agaccaacag ttcctaagcc ttggccaaaa gcagaaaggg 3831181 ctaatccgcc catctctttg ctctctaatt gcttcggtct gattcctgta tattgctgca 3831241 gattggttac atgccatata aagtcggggc tgttcgtcat gacaccaggt tgattatcat 3831301 agactttgag gccgtctgct cttggttcta tcgtcaggtt tcggcccgtc cggtctgaca 3831361 atatccagtg aagcggtaaa actgtatcca atagatctaa ttttttctct acaatcgtta 3831421 aagatcgaat cttttctttt acgtcttcca aagactgaca gactgacagc acccatgtca 3831481 caaactcatg cgggacaatg tgaacggtat cttcccgtat cgttttttcg tactccgcat 3831541 agcccggaaa ataaagcgcc gcacaagata aaccgctttc attaatgccg tcggcaaata 3831601 atatatttcc aagttttctc cccataccga taaacgcgta ctgtgtctga tgggcccttc 3831661 cgtcagcttc actgttccag ctgtaacggc gcggatagag aatcacctct gtccccagct 3831721 gaaatgcaaa atccattgtt cttgctaata catgtttacg gtcagcagtt tccaatgtaa 3831781 gacttgtgca catttgatca gtcccctttt caattcagat taatatcata catattgtga 3831841 acgaattggt tttatcagca taacgaaagt caaatcgatt cgtcaaagaa ttgacattac 3831901 atcaaataaa acgaaaaaat ccagccttta gaaggctgga ttttttatta tttagccaaa 3831961 acaagctcgt gaatcgcatg tgcaacgcca tgttcattat tggagcgtgt ttgaaagttt 3832021 gctgcttcca atacttctgg gatggcgttt gccatggcaa ccccgcagcc cgcccattcg 3832081 atcattgtca ggtcgttccc gttgtcgcct atgcacatga cttccgcctg ttcaattcca 3832141 agcagctgag ccagctggcg tacagcattt cctttgctgg cttccgagtg cagaatttca 3832201 taaaagaaag gcgcgcttct gaccattgta tatttttctc tcacgtcttt tggaatcgat 3832261 gtaatgacgc ggcttaagtt ctccggttta tcaataaaca tcactttcgg gatgaggata 3832321 tcttttggca cctcgtcaat cttgcggaaa tgaagcggca cctgtgtcac ataggattcg 3832381 tatacggtaa attcgctaat atcccggtta ggcgtataca aattagatga gtcaaagaaa 3832441 tgcatcggcg tcttcagctc taagctcagg tcatataatg aagtcaaatc atcataaccg 3832501 agagacagct ctgagaccac ttcatttgta tgcgtatttt gaacaagtgc tccattatac 3832561 gcaataacat agtcgccttc ttcaattaaa ttcagttcat ctaaatatct ctgcacaccc 3832621 ccgataggcc ggccggtgca aagcacaatt ttgacacctt ccgcttttgc cgcgtgaagg 3832681 gcgtcgcgga cctcctctgt tacttcatga tgatcattta aaagtgttcc atccatatca 3832741 attgcaatta gtttgtacat cctgcatctc cttcatgtcg ttttcaggct atagtcccat 3832801 catatcgttt tttctttttg atattcaacc ggaagagatg gttttctccg gattctgttt 3832861 agacgccgcc cttgtcttcg gatacgcaag cgcggtttcc gctttctttc tgccttgacg 3832921 ccgttttctg cttttttctg tttcatcagc agaaagccgg cagctagaaa aggaatgccg 3832981 gttatattca agatggcaag cttcacaccc gccgcgatga aaaagaaccc ccatgaagat 3833041 gatggattcc gtctgatcat gacgtaagcc gccatttcca gaacgatcag gatggcatga 3833101 agcactatgc cataaatcag caatacaagg gcaaaaaaca aaacataatt cacgattgcc 3833161 cctgagtaca tcatagcgcg catcatttgt ataaacgata aggactgcat ggagccgctg 3833221 atgacattag ggttatagat cgtatagtca ctaaataaat gtttgacttt gagaaaagcc 3833281 cataatataa atatccattg aatgatatgt aaaacaagcc ccgctgccac cagtctttca 3833341 gctttttgat ttctcatctt tctcctccct gccggtcttt gattcgattc ttgtcatcgt 3833401 ttttctctgt ccattttgct cccatatcaa tgtcccgttt tctcctcttt tcagcgtgct 3833461 tttgagcgga taataagggc cgaggtactg aatctcgata gacccgtcag tgctttggga 3833521 aatcaccttg tatgccataa aaggcagctg tacctctcct cttccttcca tcacttccgt 3833581 ttccacaacc tcgtcttcgg taaatgtgac tgttgctgat ttcacaccgt ccgttggccc 3833641 gggggcacgc ccctcatccc acgttccgta ataaaacggc gtctcttctt tttgctgctg 3833701 gcagcccgat accatgatgc atacagcaat taaaaacaaa atgccatatt tgtttctcaa 3833761 ggggatcacc attctttcct ccttttttgg gcgaatgccg tgccactgtg ccaatgacta 3833821 cataagttat aaggaattca cccacaagga gactgatcac atgaaccctt atcaatatta 3833881 cagccctcag ctgcctcagc aggaacctta ctatagccac tatgagtaca atccttatcc 3833941 gcagcaggat gtatacgatc cataccaaat ggacagacag ccggcattgg aaagaagaat 3834001 cgcagcactt gaacggcaaa atgaacagca gtcaagagaa ttaacccgtc tgacaaacga 3834061 agaccgccgt caaaatcggg aaattgcacg gattgccgaa caggtcaatc agttaagcca 3834121 ggctgttgaa cgccatacac gccgcctaaa tcggctcaat cagcgcctcc gtacagtaga 3834181 aaaccggctg aatatcccat ttactgcagg ggaaggcggt ttctgagcga aacaaagaaa 3834241 aaaagcggaa tacgattctc ccatctcagg gtttcgtttt ccgcatttct tatatgttaa 3834301 aacggaacat ttacataaaa agggtttgta cccagtatac aatctttacc gttttcattc 3834361 aaagatagag gggctgagga aaataattgt agttcctctt tgacggaatt tcttttcatt 3834421 caagttgcat gataataccg actcacgtca atcgatacat ggagggatca ttcatgcata 3834481 atacacaaca cggcttgcag cagctgaacc aatgccgcca aactgctcag cagctcattc 3834541 agcaaacaca gcaaagcagc cagcaatatc gccaaatgct tcatcaggaa cagcaaaaca 3834601 tccaaatgct gcagcagatt ctaaaccacg aacaacaagc tgcacatacc attcagcaag 3834661 cactgcacgg gcatgacatg gcgattcaaa agtgccagca ggttgtcaac atgtgcaacc 3834721 aaatgcaaca ggaacttact ggacaatcca gcgtcatgaa tacgaatgtg tctacacttc 3834781 cattcggcca aaacacgaca tttcagcagc aatcctacca gcagtaacat ataaaaagct 3834841 caacacaatg cgagtgttga gctttttttc ttactgttct ttgcgaatat gtatatcctg 3834901 aatagactgt ttcggtgcat gaaatctgct ctcggcttca cttcttgcct cggcaaaagc 3834961 ccgcgcctcc acatgatctt tgtagacatc cagctgaatc aaatacagcg ggcgcacttt 3835021 aaatccatga ataatggtta ccgcccataa cgggaccaca ataaaaacac cgggcagatc 3835081 gggcaaaaca aaaccaaacg caaaaatgaa aaaataaatg atgccgtaca tgatccactt 3835141 tctatttcta accttgatgc caataaataa aaaggcaaaa aaactggtaa tggcaaaagg 3835201 catgaaaata aacagcatcc accagctatg cagccattcc caagcggcac ctctttttgt 3835261 aattcccata tttttctcct cctatttacc tataataatc gattaggcac accgcgtcac 3835321 ccataaacgg gaaaaacttt ctcccttaaa aatagtgata gacggagaac aggtttcttg 3835381 ctatattatt aattgataat gataatcatt actaatctat tgagatacat agtgggaggg 3835441 ttcttgatga aaaagaacat attgctcgtg ggcatgcttg tgctgcttct catgtttgtc 3835501 agcgcttgca gcggcacggc ttctaaaggg agctcaagcg attctgcttc cgaaaaaaca 3835561 gaaatgagaa catacaaatc accaaaaggg aacgtcaaca ttcctgcaca tccgaaacgc 3835621 atcgtcactg atttttatgc cggtgaattg ctgtctgtcg gggccaatgt ggtcggctca 3835681 ggctcatggt catttgataa tccgttttta aaatcaaagc tgaaaaatgt gaaggatgtt 3835741 ggtgatccaa taagcgttga aaaagtgatg gagcttcagc ctgacttaat tgttgtcatg 3835801 aatgaagaga atgttgataa attaaagaaa atcgctccga ctgttgtcat accttataac 3835861 acagcgaaaa acgtagaaga cacagtcagc atgttcggag atatcgccgg agcgaaagac 3835921 caagcaaaat cctttatggc tgactttaac aaaaaagcgg aagcagctaa gaagaaaatt 3835981 gccggcgtca tcgacaaaga tgcaaccttc ggcatttatg aaaacacaga caagggcgaa 3836041 ttctgggtgt tcaatgacaa tggcggacgc ggcggccaag ctgtatacaa tgcacttggg 3836101 ttaaaagcgc ctgaaaaaat tgagcaagat gtcatcaaaa aaggagagat gaaacagctc 3836161 tctcaagagg ttattcctga gtatgccgca gattatatgt tcattacgga ttacaacccg 3836221 aaaggcgaaa gcaaaacact cgacaagctg gagaattcct ccatttggaa aaatcttgac 3836281 gctgttaaac ataatcgcgt gtttatcaat gactttgact cgttctaccc gtacgacccg 3836341 atttctgtca gcaaacaggt ggatatcatc accgacatgc tgatcaaacg ggccgaagaa 3836401 aataaaaaat aaaaaaacgg cacagtcatg acgctgtgcc gttttttatg attcacttta 3836461 attttgactg tacggagtcc ggcatatctt caaacttgac ttcttcccaa gtctcgacat 3836521 actttccttt cgccttcacc ttcaaatacg cgttcttccg aagctctttg ccggcgaaaa 3836581 aggtcacttc ttcttttttc ccggatgcat tatatccgtc taatgtatat tcagtaccgc 3836641 ccggactaag atgtctgcca tctcgatcaa tctgaacata gacatcttgc tggtgaataa 3836701 acggattaaa tctgtctgta acatcgttat gaaaaaagag aagcccgcat attacggcag 3836761 cagccgccaa gacggccagg attgccattg cttttttcat ctttgcactc cccttacttg 3836821 ttcatttttt tcaaatagct tgaccgcacc gcgaggaaga atagaagctg aaaaatgaaa 3836881 aaccctccga tggtgagact gagcggcccc gctacatcgg aatatccttc cacagccaat 3836941 gttctcaagg caaacagtgt atgcatgacg gcaatgacaa atggaaagaa gaaaagaatc 3837001 gccaattgta ttgtcacgct ttgcgccatt tctcgctcac tcaggccgat tttggccagt 3837061 gaacggtagc gctcccggtc ttcatctaaa tcagtgaaca gcctgaaata taagaaactt 3837121 gctgccgcga caaagaatac aattgcgata aacaggccga taaatagact caggctcggc 3837181 agctgcaccg tatcatagta agtccccgct tttgaagcaa aatcagaatg cacgtcgata 3837241 taattgccgt aaatctcatt ttgcaaggat tggctgatct caagactgtc tttccaatga 3837301 tcatagctgt agccgtataa tgacgcttta tcaccgagtg atttcagctg atcaaaggtt 3837361 tgatcattca ccgcgatgat agcattcaat gagatcagcg gttttttgac ttcttttacc 3837421 gacagttttt gatcagacag ctcccctttt tggttcagca gcttcagctg atccggcgct 3837481 tcgtttttga aattgcggtc atacgttccc gggaaataga cagcctcgtc ttctttcagg 3837541 ccgttcactt tgacatggaa gtattttgcc gcatccgatt cactgatcat gtaaacaggg 3837601 ggaacagttt ctccttcctg atagcgaaca taggaaacat ctattttgtc tttcgtatac 3837661 gtaaaaccgt gtgttttcag ttcatggtca atatctttca aatgagtctg ttcttttgga 3837721 ttgttgctgt aagataaata ctccatttca taagcggact cttccgctcc gacggtcgat 3837781 ttgtacattg cgagcacgcc tgtcgcagta aacgcaaccg cggaaataat gctgacaata 3837841 aagaacaggc gggcgttgtc ttttagacga tagacaaggt cagaaaccca aatgatgttt 3837901 ttcccgcgca gataaaaggt tttccacttc ttcagcgcgc gcagaatcca tatgctgctt 3837961 tggctgaaaa agaaatatgt tccgataacg gtgagcagta aaatgataaa cggttcggcc 3838021 ccgtggacat tgcctttaag aaccatgccg tacccgccgc acagacaggc gatgccgaat 3838081 aaggacagaa gcacggacgg cttaggctcc ggtttaacct tgccagtgcc ctttattaat 3838141 ttgataaccg tatttgatct gacaaaaagg atcgtaaact gcgataaaaa gaaaaataag 3838201 agcagaaatc cgcaggccgt aataccgagc gctttccaag gcatatacaa aggcagcgcg 3838261 tccatttcta aaatataagc gccgaccgta aagaacgtct ttgaaaaaat gaatcctccg 3838321 ataataccgg ctgcaattga catgacgccg atgatcatat tttccgcagt aatgagcttt 3838381 ctcagctgcc ccggcgtgat gccctgcatg agcagaatgc cgaattcttt atttctcgat 3838441 ttcaaaaatg cattaaccga atacagaaca aataagaaag aaaaaacaaa gatcatccat 3838501 tccgcggcgg ttaagccttt tttggcgatg ttattcaggt agccttcctt taatgccgga 3838561 tgaaacagga acatcgcaaa ggtaaagaaa atcaaaacgg aaaaggcgct gcttaaaaag 3838621 aatgcaagat aggccctttt gtttctcgtg acgtttttat aagcgaactg aagaaaggtc 3838681 atttgcgttt ccccccagca tagacagcac atcgagaatt tgttcataaa atacttggcg 3838741 gttttccccg cggtaaatct cattaaacag ttcgccgtct tttataaaga tgacgcggcg 3838801 gcagtagctt gccgaaaccg gatcgtgggt caccatcaaa gccgtgacat gatcatcccg 3838861 attcaggctc tgcaacgttt ccatgacgtc ttttgtcgct ttggaatcaa ggtttccagt 3838921 tggttcatcg gccagaatga gtgacggctt atgaatgacc gctcttgcga tggcggcccg 3838981 ctggcgctgg cctccggata cttcaaacgt ccgcttgtta agcaggtttt cgataccgag 3839041 ctttgccgcg atgccgtgca gtttttcttc cattacagac ggcgcttctt tttcaagcgt 3839101 taacggcagc atgatatttt caccgatcgt cagcgtatcc agaaggttga aatcctgaaa 3839161 cacaaatccg agctgcttgc ggcggaaatg agcgagcttt gtccgcttca ggcgatgcgg 3839221 gttttctccg ttaatcagga tatcgcctga atctggacgg tcaatcgttg aaatgatatt 3839281 caaaagcgtt gtttttccgg acccggacgg ccccatcacc gccgtgaact cgccttcttc 3839341 tattgaaaat gaaatttgct ttaaggcctg ataggacact tgtcctttat aggttttatt 3839401 tatatgtttg acttcaagca tattcgccat gaaaatcctc cttatggttt tattcttgtt 3839461 gatctgggct gctttcatgt agtgccggga cgttcaacat aaaaatcccc ttgacataaa 3839521 tccatgttat caaggggaaa caaagcgggc tatgttgttt tcttaacgca gccttacatt 3839581 tttgtaagaa atgaaaatcg aactgatgtc ccttcaccgg gagacgagct gatgtccacc 3839641 gtatgattga gcttatctgt aatttctttg acgagatgga ggccgattcc cgtagattct 3839701 tggaaacgcc gcccgttttc acccgtgtaa taagggtcaa acacccgctt gatgtcttgt 3839761 gagggaatcc cgacaccgta atctttgact tcaagcaccg tcctgtcttc atcgcagaag 3839821 acattcagct caagtctgtc actcttgccc gctgaatact tgaccgcatt tgtgaccact 3839881 tggccaatcg caaatttgag ccatttggca tcggtgtaaa tctgatgatc atcgcaaacg 3839941 ttcattttcg gataaacgcg atattgaata aaaaatcgtt tatagctttg aataactgat 3840001 tggagaagct cggacaggga aaccgcttcg attttaaaat cccgttcaaa caggtcgagc 3840061 cttgaagaat aaagaagcgt ctccagcccg aattcaatct gccggacttc ttttttgatt 3840121 tgttcaaaaa cgggctcatc ctcttcttga atgattaaat taatgaccga cagcggcgtc 3840181 tttacttggt gcacccattg attcatatac gtcacccgcg cgtcaagctt ggcttcggtc 3840241 tcatggagct tctggtgctg cagccggatc agctccatct gcttttcata cagctctgaa 3840301 cagaacactg aagaaccgag atacgggata tccgtccctt cctgccccga gctgagccaa 3840361 tgatacacgc cgcggtcttt gtaccagcga taggcaagat agcccgccaa aataagaagc 3840421 tgcacgccca atatgtaaaa caagtgagaa aaagaatgaa gacccgcaaa ccagtaataa 3840481 aagaagacaa acagcccttg aaggagaaaa agcagaatca gcactgcatg agaccggaga 3840541 aacagcttca tgactgcgcc ctcagctggt agccttcgcc ccgcaccgct tcaatagaaa 3840601 caggcgcatt cagctcccgc agtttttttc tgagccgcgt gatatacacg ttaagtgtat 3840661 tatcatcgat gaatatgtcg gtgtcccacg tcttttccat gagacggtcc cgactcgtca 3840721 ccttttctcc ccgctcaagc agcacttcca aaagcttgct ttctttttta gaaagctcac 3840781 ttttttcatc ctgaaaacgc agttcaaacc gttccacaaa gagctgaacg ccggcatatt 3840841 caaccacttt ctctccctgc tttgcggcgt actccccgta cgccctccgg atctggcttt 3840901 tgattttcgc aagcacaata tcataagaaa acggtttttc gatataatcg tctcccccat 3840961 tttcaatcgc catcacctga tccatttccc cgcttctggc agaaataaag atgatcgggc 3841021 ttgtggagtg ctggcggatc tgccggcacc aataatatcc gtcatatgcc ggcaaattga 3841081 tatcaagcag caccacatcg ggcttttccc gcaaaaagac atcaagaaca gctgtaaaat 3841141 ccgcggcgac cactgtttga tatccgtatt tttcaaggta attctgcaat agtccgcgaa 3841201 tgtcttcact gtcttccaca atcatgattt tattcaaact gaaccactcc cgtttcttac 3841261 actgctgcca tcatcataat cgttttgggc gtatggacgc aacaccgcac aaaaaaaccg 3841321 ccatctcggc ggtttctggt ctctttagcc gacctgctgc ttagctgctt taccggctga 3841381 tccgaactct ctcattttgc ttcgcactgt ctcttccacg gcttcaatgc cgggtgtcaa 3841441 atagccgcgc ggttcgtaca gatcgctgtt ttcctgaaac atgcggcgtg tttcgtctgt 3841501 ccacgctacc atacattccg tattgatatt gatcttcgcg tggccgagcg tgatggcttt 3841561 tttgatctga tcctgcggaa tcccggatgc cccgtgaaga acgaggggaa tatcagtcat 3841621 gcgggagata gcctccattt ccttaaatcc gagattcggc tcaccctgat atttgccgtg 3841681 tacagagccg agggcggcgg ccagcgcgtc gatattggtt tctttaacga tccgctcaca 3841741 ttccgtgata tccgcatagc ggaccccgcc gaccagtccg tcttccattc cgccgaccgt 3841801 gccgacttcg gcttctactg acacgccgtg ttttgcggca taatcggtga cttcttttgt 3841861 catcgcgata ttctcgtcaa tcggctgatg ggagccgtca atcatcactg agctgaatcc 3841921 ggcatcaatg gcctgtctgc agcgttccgc actgctgccg tgatcgagat gaagcacgac 3841981 cggaacggta atcgccatgt cctctattaa cgcgccgacc atggcggcaa tcgttttaaa 3842041 tccgcctaaa tagtcgacca ggcgatcgga agccgcggcg atgaccggtg attgctcctt 3842101 ttgcgccgcc tgcaaaatcg ccttcgtcca ttgcaggccg ttgatattaa actggccaat 3842161 tgcatattgc tcccgctttg catcttcaag aagctctttc atcgatacaa aagccatatt 3842221 cacccctcct ttatccatta catgctgaag tattttgata cgacatccac tgttgttttt 3842281 ttcgctgttt gaatggcttc ctcagcagtc agcttatagt attcaggccg gaagagctca 3842341 accgaaacaa catcagagaa gccgatttcc ttcagtgctg ataagtgggc atctaagtca 3842401 attgcccctt gtcccggcca tacacgatcc tcatctgtta aaaagccgat tgggaaatct 3842461 tctgtatcat caatatgata gatgaagatt ttctttccgt ccgcctgctt taagctctca 3842521 atatttgaac ccattgcatg gaagtgaaaa ctgtcaagga caagcccgac attgtcacgg 3842581 ttaactgtgt ttacaatctc atacgcctgt tcaaacgtat tgaccgtaca ttgcggatgg 3842641 ccgacaaact caagcgcgat ttttacgccg tacggctccg cgatatctga cagctcagtc 3842701 agcacgtcta cactgctctt tttgatctct tcttttacaa tcttctgctc tgtcacaagc 3842761 ggaacggcca ccacatattt cacaccgagg gttttgcatg tttccatcat gcctttaaat 3842821 tcagtgatga tctcgttgtg acccttttca tcacggttgt tgaagaaaac gagtgcgttt 3842881 aaggcaagcg gtttgatgtg gtgggtttga aaatattccg caaggtcatc caatgaatga 3842941 tcttttaagt actccggcag cttatccata gtacggattt caatataatc atagccatgc 3843001 ttttcgcata gttctaaatc cagtttaagg tttgagtttt ccaatgttgt cgcttcatta 3843061 aaacaaagtt tcatgccaga ctcccccatc tgcgttttag atatgaaggg agttcggcag 3843121 gaaggctgtc gccatatccc gccgaactcc atgctcagct tatgccagac ctaattcttc 3843181 tttcattttc ttaagcataa atcggcttga ttcatccgct ctttcatcga cccaagcaaa 3843241 tacggcattc gtcgcaattc cgtcgaactt catctctctc agttttctga aaatcgtatc 3843301 aaaatcaacc tcgccttggc caatgtccaa atgctggtga accgttactt tcgcgtcagg 3843361 cggattgacg atgtagcgaa ggccatgagc cgctttatga ttataggtat ctgcaaataa 3843421 aacatgtgtg aggcggtcgc cggcttcgtc aaacatggtc tcgatgtcgc ctttgccgtc 3843481 atcatagaag aacgtatgcg cagtcgagta gacaagattg atccaatcct tgtcaagcgc 3843541 gcggatcata tccatcgcac ctttgtgcgt ttcgataaaa tcatatggat gggcttgaag 3843601 attgagttta atgccttctt tttcaaagac tggcagaagc tcatccatgg atttgataaa 3843661 tttttcttca cttgttaaag gatcatattt tgaaccgctg aattcgctgt tcatcaaatc 3843721 cacttcaagt tcaaccgcaa tttcgattgc ccgtttccag ttgcgcactg ctgcctggcg 3843781 gcggtcttca tcgggtcccg cccagtggta aagaggaaga agcgatgaaa gcttaacacc 3843841 tgtatctctt aaaaggcgct ttaattgttt gatctttgct gaatcgactt tcggatattt 3843901 ataaaacggg caaaaatcct cgcgcggcga taattcgata tattcatagc cgagctctgc 3843961 cgttttatag accatttcct ctaaagttaa atcatcacga tacatggatg gatccaatgc 3844021 taacttcata ttttcactcc tctgtttttt agttttgaac tgttgtaaaa gattgataga 3844081 attccggttt ttccttcaat tcaacctttt ctttttgtcc agattcctgg gcttttacac 3844141 acgcgtcagt cgtgacagca gcaatatagc cgtcccatgc cgtcggtccg ctgacctcgc 3844201 ctttcttttg aatcgaatca ataaagtctt ggatttccac atcatacgca gcgacaaagc 3844261 gtctctgcca atccatcaaa atatcagtgc tgaatctgcc ttcttttctc aagctgatgc 3844321 ttgatggctc gggaagcttg atgatgccgt cttctccgac gatttcacat tgaatgtcat 3844381 agccgtattt acagttcaca tagatttcag cattgatgac gataccgcct tttgtttcaa 3844441 tcacgacgat ttgcggatct tttaaatgtg gaagcgcgtt ttttgatttt ttcggataga 3844501 tgacttgaac ggactcgtag tcatcattga cgagccagtg gagcacgtca atttcatgaa 3844561 caagcgtgtc gactacagcc atatccgttg tatagttatc tcctacagtc gggttgcggt 3844621 gcgcgcagtg aatcataaga ggctcgccga tgacatgatt atcgagcgct tctttcagct 3844681 gtacgtaacc gctgtcataa cggcgcatga agccgacttg aacaaggcgt ttgcccactt 3844741 tgatttcttc ttcgacaatg cgcatgcatc cttcagccgt tgtcgcgagc ggtttttcac 3844801 agaacacata tttctgggct ttaatcgctt tcagcacgct tgactcatgc gcaggccccc 3844861 agcttgtcac taaaacagcg tctacatttt cgtctgcaag caagctgtca tcattcggat 3844921 aaaccgtcgc gtttaattgg tattgctcaa cgaccttttg tgcagcttct tgattaacat 3844981 ccgttacagc tacaatttcc gcgcctgaca gcttgttcgt gatacggtta atatgttctt 3845041 ttccgattgc tccagttcca attacgccaa tacgtaaact cattgacagc cactccttct 3845101 gttggttaca tgattttgct ttctgttcct ttctttactt ggctctgagg agacccgtag 3845161 agttcctctt gaatttgttc aagcgacttg ccagacgtat tcggcgcaaa gagcagcccg 3845221 atgatcatac tggccgtcac acatccgaga agaattgcag ccatcgttcc aatgccgaaa 3845281 ttggtgataa tcattgggac aaacagactc caaatcccta ttgaaatacg gacaaggaaa 3845341 aacatcagtc cttgtgcgga agcacgatat tgcgtaggaa agatttcgct ggcccataac 3845401 tgatagttcg cttgctgccc ggctccgtta ttgatgccga tcacgacaat aaacaggagc 3845461 agaatcggca ggccttcaac tggcagcaga aacagtgtcc acccgatcac cgccatgaaa 3845521 gcggcgattc caaatacggt ttttctatat ttgtcggcaa agggcatgaa gatcaaggcg 3845581 acccccaatc ctgtgaagat aaacagcccc atttgcaaaa ggttggccat gttggcagat 3845641 acaccgccga cctgctgata aatgtatggc ataaagaagc ccatgacccc ggcggctagg 3845701 ttccaaacca agtacacacc catcaaaaac aggatgcttt ttagatacat aggcttgagc 3845761 aaatcaaaat acgatgtctt attcaataca gccggcttct ctgcctgagc ttcctccggc 3845821 tgattttttg tctgccaggc gtctgattcc ggaagcctga ttctcaggat gtacgtaatc 3845881 agcgcaatca caagcagatg ggcaaatacg attttattcc ccaagagtcc caagtcaccg 3845941 gccagtacgg agaggagcag tacaacgaca gcgcccgcgg cccaagcgac ttgtgctacg 3846001 ccgcaatgcc tggcccgatt cttctttggc gcattttccg caataatggt ccatgacgcg 3846061 gttatgtcag cccctactga taaaccgata atgatgtaac cgcttaacaa catggggaaa 3846121 ttaaccccga acaaaaccaa acaaatccct agtgcataaa ccagcatact attggtataa 3846181 acagccttcc gtccgacttt atcagccaga aacccgccaa gcagcgcgcc gacagcggca 3846241 gaaatcgcat ttgcgctcaa cgcgccgagc agcccgattt gcgtatcgga tagcttaagg 3846301 taactgaccc ataatgataa accggcggag cctgccacaa ttgaaccggc atcaatatag 3846361 ttggccaatg ctgccgcgat tgtccgttta ttgaaggctg aatctccatt ggtattgccc 3846421 atatgttcat tccccattaa gccagatcca acaactgctg atcaatatag tttctcgcaa 3846481 tcaatgcata ctccagcggg tttgcaacat cggggtcttg ttcagcttca atgacaatcc 3846541 atccggaata actgtgcttc aacagcagct gatatacttc tctaaagtca atgcagccgt 3846601 caccgggaac cgtaaacatg ccttttaaaa atgattgccg gaacgattgt ccttcgagcc 3846661 tgcattgttc catgacattc aggcgggcat ccttaaagtg cacatgctta atgcggccga 3846721 tatgcttctc aagcatcccc atgtaatcgc cgtcagaaat atacgcatgg cctgtatcat 3846781 agaggaggtg tacatgcgca gggtctgttc ctgccatcag gcggtccact tcttccgctg 3846841 tttggacacc agtgccgaga tgatgatgat agacaagctt caagccatgc tgagcggcaa 3846901 tttcgccaag gtgattcagc ccttcgcaaa gccgctccca ttcatcatcc gtaaagtgcg 3846961 gcttctctgt gaacacattt ttctccaagc tttgcacgct gtacgtttgt tcagagacaa 3847021 ctgcgacatc cgcgtttact tgctgcaaat actcacaatg cagggtaaat gtctttgccg 3847081 cttcaccaag tccgtcacgc aaaataaaac tgctgaacca ttttcctgca atgcgtaagt 3847141 tccgaagctt cagctctttg ttcaggatgg caggttcggg gaaaaagccc ccgacctccg 3847201 tgccttgaaa acgtgcgaca acgatatcac ttaacaaatg ctgaagtgta tttcccgctc 3847261 caatttcagg catgtcatca ttccgccacc caatgggagc gattccccac aggatttcat 3847321 ttttgcccat ctatggtgcc tcccctctaa tactgcttcg cagattccag ctttttctct 3847381 tttgcttcgt atgctttctg aacgctttct tgttcagata cctctgccac cccgacatgc 3847441 caccagctgt catagccgtc cgtcattgtt ttaggcagca ccttcatttc aattaatgtt 3847501 gatacatcct gtttcttcgc atcctctaac gcagctttta attcttctac tgtgtttgca 3847561 cggtaggttt tcgcgccgta tccctcagcg actttcgcgt aatcgacatt caggatttgg 3847621 ttgtcatctg tgcggaactc gcaatagtag ctgccgctgc cgtgatccat ttgcaggttg 3847681 ttgatgcatc cgaatcctga gttgtcaaag agcagcacat tgattttctt gttgtactga 3847741 atcgccgtga tcagttcaga atgaagcatc aggaagctgc cgtctccgac gattgaatac 3847801 acttctctgt cagggtgggc cagtttaaga ccgagtgtcc cggacacttc atagcccatg 3847861 caagaatatc catactccag gtgatacgta ttcggaacat tagaatgcca cagacgctgc 3847921 aaatctcctg ggagtgagcc tgctgaacag atgatgacgc tgtcttcagg aatcgtctcg 3847981 ttgattgtca gcaatgccgt tgtttgcgga agctccgtat tcaacgcgtc agcatattca 3848041 ttcaggacct cttgagaaaa gtgatttttg atttccggat caaatgcttc ccgcttaaac 3848101 gtcactttgc tgagacgctc gcgttcagct agccattcgt ccttcagctc ccggatcgtt 3848161 gtgccgaact cgctctcata gccttcaagc aagccgtgca gtttgccaag cgtcactttc 3848221 gcatccgcca ccacttggaa tgcatcaagt ttatacgcct gcattcggct gacgttaatg 3848281 ttcaaaaact tcgctttatc aaaatcaaaa gcggtcttag aggatgtcgc aaaatctgta 3848341 taccttgtgc cgatgccgat aatcaaatca gcttggcggg ccgctttgtt tgccgcaagt 3848401 gtacctgtga tgcccattcc gccaaggttg ttcgcaaaat ctgcctcaac ggtagacttt 3848461 cctgcctgcg tttcaactaa cggaatgtta taggcttcag aaatggcaac caattcatcg 3848521 cgcgcaccgg aatattttgc gcctccgccg acgagaatca caggtttttt gctggattta 3848581 atcagctccg ccgcaccttg aagctcgcgc tcgctcggct gcatgcgatc aatatagtga 3848641 acccgtttga cgaagaaact ttcatcaaaa tcgtatgctt ccccttcaac atcctgagaa 3848701 atacaaatcg ttgccggacc tgcttttgcc ggatcagtca tgacttcaaa cgcgcgcagc 3848761 aaactgctca tcagctgctc agggcgcgta atgcggtccc agtatctcga tacaggcttc 3848821 aatgcatcgt ttgtcgtaat cgccgcactg tattcttgct ccatttgctg cagtacaggg 3848881 tctggctgtc ttgtcgcaaa tgtgtctgcc ggaatcaaga gaactgggat attatttgcc 3848941 aatgcagtgc cggctgccgc caccaagtta gccgctccag gtccgacgga tgtagacacc 3849001 gcatatattt ttcttctcag catttgcttg ctgtacgcca tggccgcatg cgccattcct 3849061 tgttcatttt tcccttgata gactttcaaa tggcctgcat cctgctcaag cgcctgcccg 3849121 atccctaata cgtttccatg accgaaaatc gtgaagatcc cttcgacaaa aggctcttcc 3849181 tttccatcta catggatgta ctgctggttt aagaatttaa tcagcgcctg cgcagttgtt 3849241 aagcgaattt tcttacccac aaacgatccc acctttactc gatctttttc aattatgact 3849301 gtgcttcaat aagctgttcg atttcttccg cagtcggcat cgcttctgac gaactgtgct 3849361 tgctcaccac aatggaggct gaagcactgc cgtatttcaa tgccgtttca atgtcttttc 3849421 cgctgacaag gccatagata aaggctgacg cataggagtc accggcccca aaggttttca 3849481 gcacttttgt cttgtacgct tgagcgcgga atacctcgcc ggatttgctg tatgcgtaag 3849541 agccttcgac gccgtgtttg atgacaacga ggtcggctga atggccaaat aaatgattga 3849601 cggattcttc attgcttccg cctgtgcggt tttccatcac atcaaattca tcgcgtgtgc 3849661 cgatgacgat atcagactgc tcggcaacca aagaataata aacggctgtt tcatctgatg 3849721 actgccacgt atatggccgg taatccagtt cgaataccac cttaacctga tgctttttcg 3849781 cgtattgaac agcttttaac accgcttccc gtgacgggct tttggcgagc gctgtcccgg 3849841 agacaagcag cattttcgca tttgcgatat agtcctcact tacctctgaa ggctcaagat 3849901 aaagatccgc cacatcatcg cgatacatta agatgctgca ttcttcaggg ctgaggattt 3849961 ctgtaaatgc aaggcctgct ttgtgtccat cttgatcaac aatcatctgt gtagtatcca 3850021 cgccggtctt tctcatatag gactctatga atcttccatg ctggtcatcc ggaattttgc 3850081 cgatgaagcc cgcttttaag ccaagcttcg cgctgccgat cgcgatattc gcaggtgaac 3850141 cgccgacata tttcgaaaat gtcatcgttt cttccattgg gcggttgtat tcgactgcgt 3850201 tcagatcaat acatgcccgg ccgatggcaa caatatcaaa agccttctct tcattgaatg 3850261 tatacttcat cgtaaacagc cactcctcac ttgttagcgt tctaaaatcc attcatgcgc 3850321 cgggtcgtta taaaacttcc attttcgcgt cggccctgcc atgacattta aatagtagga 3850381 tgtgtatccg tccggaacgc ctaccgggtg gtatcccgca ggaacgatga caacgttttc 3850441 atttcccaca gtcattgtct cgtcaataga acggtcatct gtgtatacgc gctgaaacac 3850501 aaagccctgt cccgggtcta actcatggta gtacgtttct tctaagaaag attcttccgg 3850561 caagttgtct tggtcatgtt tgtgaggcgg gtagctggac cagttgccgc tgtctgtata 3850621 gacttcaact actaatagac tgttagctga agggtctgaa tccggaagaa tgttatgaac 3850681 agtacgtttg tttgaaaatt gcccgcgatg ctcaattccg ttgtcttccg ctttgatcag 3850741 ctttgtcgga agctgctttt ccgatggaga atagcaaagc gccactcttg cgtcgctgac 3850801 cgctgtgatc tcaaatgcac ggtcatttga aatatagacg ctgtctgtcg gttttcgttc 3850861 aaatacgctt tcgcgcgtgc cgatattctc aaaagtcgac tcatgatctg tcactgtaat 3850921 tttccccgtt accgccacaa tacagatttc ttgttttttc aattcttctg tatagcttga 3850981 acctgatgca agatctaaca ctttaaactc tacataagtg agatcagagt tggatgtcgt 3851041 tacttcgtgc acgagtttga ccccattaga cacttcatgc gactgcggct tacgcaacaa 3851101 ataactcata gagaagccct cctctttcta ttggcagaat gagtccgaac agcgcacatg 3851161 gacgccgttc ggctgttcgt cgtttagttg aaatcaggtg ccggatatct tgccgtcacc 3851221 acttttttac gtgtatagaa gtcgacgctg tcttttccgt tcgcatgcag cgttccaaag 3851281 aatgaagatt tccagcctga gaatgggaag aacgccattg gagccggcac accaaggttg 3851341 atgcctagca ttcccgcatc aatgttttca cggaagtagc ggattgcgtt tgagttggat 3851401 gtgaacaagc aggcgccgtt cgcaaactca gacttattgg cgatttcaat cgcttctttc 3851461 aggtttttca cacggatgac agataagacc ggagcgaaaa tttcatcttt ccagatcgtc 3851521 atttctgttg tgacattgtc aaagatcgtc gggccgacaa agtagccgtc gtcagacaca 3851581 ttttcacgtc cgtcacatac gagtctggca ccttcttcaa gacctttttc gatatagctg 3851641 agcgtgcgct tcttgttgtc ttcgcgaatc accggtccta agaacacgcc gtcatcaagg 3851701 ccgttaccga ttttaatgtc cgccactttt tcctgcagct tcgccataaa ttcatcggcg 3851761 attccttctt caactgtcac aaccgcacaa gccatgcagc gttcaccggc agaaccgaag 3851821 gcagctccaa cgatgtttgt aaccgtgtct tcaagattcg catcgttcaa gacaatcgta 3851881 tggtttttcg cgccagtcag agattgaacg cgttttaagt tttcgcttcc ttttttgtag 3851941 acgtattcgc ctactggctt ggagcctaca aatgaaatcg ctttaatttc gggatgctcg 3852001 aggatgccgt tcacaacgtc atgcgcaccg tatacgacgt tgaacacccc tttcggaagg 3852061 cccgcttttt caaaaagctc aaccaatttc tctgttaaca gcggagtccg ctcagatggc 3852121 tttaaaataa atgtgttgcc gagcgcgatc gccatcggga acatccagca aggaaccatc 3852181 atcgggaagt tgaatggcgc gattccgccg acaactccga ttgggtaacg gtagttcgcc 3852241 gcttcaacgt ccgttgcgat ggaagcaagt gagtcaccca tcatcaggga aggtgctcca 3852301 gcggcgaact ctacgttttc aatcccgcgt cccacttcac ctaaagcttc tttcgtgttt 3852361 tttccgtttt caatggtaat tagatgagca agttcttctt tatgctgaga cagcagctgc 3852421 tggaagttaa atagaattct ggcgcggcga ggaaccgcca cctttgacca tgttttaaat 3852481 gcttcagccg ctgtttgcgc tgcgtaatca atatcctctt ttgtagaaat cggcacttgg 3852541 catagcactt ctttcgtcgc cggattgacg acatcttcat attgatctgt tttgctttca 3852601 acccattcac cgttgatgta gttttttaat tttctgattt ctgccattct tattgcctcc 3852661 ttcattagta aacacataca cttgtatgga tggttccgga tagattcata tcaatatcca 3852721 cttttcagca agccaagaat taaacgcttt caaaaacacc aaaaaaataa atggcggatg 3852781 catatttaca tacaagcaac catttcatgc acaacaggtt actttttggt catttcttgg 3852841 ttatattcta atcgcataat acccataagt caatcataaa cactacattt tttcattatt 3852901 tttattatat taatctttta atcaagtaag agaagtaaga gaaggccgtc caatcttgca 3852961 aaagatatac accgatgtta tcatttttaa gcaactattg attaactttt ggtttttatt 3853021 atatatttat gttacgtaaa gattcaagaa ggagtttttt atatgaaact gatgcggatt 3853081 caggaaatgg aggagtacat tttatcgcat ggcactgttt ccttagatga gctgtgccag 3853141 gtgttcaatg tctccaaaaa cacagtcaga cgtgatatca acaagctaac agaaaagggt 3853201 gcgattgaaa aagtatacgg cggcgtaaca tctattgaaa aaaccgcatt agttcctttt 3853261 gaaaatcgca ccattcagca ccaggatgaa aaaacaaaaa tcgcccatta tgcttcccga 3853321 tttattgaag atcacgattt ggtcttcatt gattcaggaa cgacgacaaa gtctattctt 3853381 gatacgcttg atccagccaa aaatgtcacc atcttaacca acagtttaga cattatcaat 3853441 gcggcgtcag ctttgaagaa tatcaactta atcattatcg gaaacaacta taagagaaaa 3853501 acccgctcct ttgtcggcat ggacgacccg gctatgcttg ataagtacaa tatcaacaaa 3853561 gcctttatgt ccgctaccgg aacgacgctg actcacggat tgaccaattc ggatctgctg 3853621 gagtatgaaa ttaaaaagag gatttcagaa aaagcaaaag aagtgtatct attggctgac 3853681 cattctaaat tcggaaaatc aacgcttctg acgtatgcac cgtttgacag gctgcattgc 3853741 attgtgacct ctcagccatt agacgacgag tacacgcagt actgcaatga gcatcaaatc 3853801 ggcattcatc tggcctaacg tttacaatag tgttgagagt ctatcatcca ttttattcta 3853861 ggaggcagat catgaaaaaa gcgaagctcg gaaaatcaga cttgcaggta ttccctatcg 3853921 gattaggaac aaatgctgtc ggaggacata acctctaccc gaacctaaat gaagaaaccg 3853981 gaaaagaatt ggtgcgcgag gcgatccgta atggcgtgac aatgttagac accgcttaca 3854041 tttacgggat cggccgttcc gaagaattaa ttggtgaagt gctgcgtgaa ttcaaccgtg 3854101 aagatgttgt catcgcgaca aaagccgctc acagaaaaca aggcaatgac tttgtctttg 3854161 ataattcacc agattttctt aaaaaatcag ttgatgaaag cctgaagcgc ttgaataccg 3854221 attatattga tttgttctac attcacttcc ctgacgaaca tacgcctaag gatgaagccg 3854281 ttaacgcgct gaatgagatg aagaaagccg gaaaaatccg ttccatcggt gtatccaact 3854341 tctctttaga gcaattgaaa gaagcaaaca aagacggttt ggtagatgta ttgcaaggcg 3854401 aatacaacct gttaaaccgt gaagcggaaa aaacattctt cccgtatacg aaggagcata 3854461 atatttcatt tatcccttac ttccctctcg tatcaggttt attggcagga aagtatacag 3854521 aagatacaac gttcccagaa ggcgacctgc gaaacgaaca ggaacacttc aagggtgagc 3854581 gtttcaaaga aaatatcaga aaggtcaaca agcttgcgcc gattgccgaa aaacacaacg 3854641 tggatatccc tcacatcgta ttggcctggt atttagcaag accggaaatt gatattttaa 3854701 tcccaggagc aaaacgtgcc gatcagctga ttgataacat caaaacagct gacgtgacgc 3854761 tttctcaaga ggatatttca tttattgata agctgttcgc ataagaagaa aacagccttc 3854821 tccaatggag aaggctgttt ttttgtgcga taaattccta aataactgat tttgaagcaa 3854881 aaccttacaa aatgagccat aaatccgata aaataaaggt agtttatctc agaaagaaag 3854941 tgattgagaa agcaaaagta tgaaacgttc atatcatcta gctcatatga aataaagctg 3855001 acccagcttc ttttatttgc tggtcagaat agcggaccgt ttcgatggtc tatggaggaa 3855061 acagaatgaa acttaaatat gtaaaagcct tagttgcagt aaccgttgct ttaggtgtac 3855121 tgctgccatc aacgatttct catgcaaaga gctttagcgg ccgctcatca tctagttaca 3855181 gcagccgaag ttcaagctca tcatacagcg gaagctataa atcaagcccg aaatcaagct 3855241 acagctcagg atcaagctct tctagcaaaa aatccaagac gtctgacgat tcatcatcat 3855301 cgatttcgct taaaaagaag ccttcggaaa aggcaagttc atcaagctct aaaaaatcgt 3855361 caggcacctt ttccggcgct acatcaaaag taaccggaaa gacatacagc ggaaaaacgt 3855421 ctaaagccta tgttggcgga cgttatgttt cagtcaatca ttactatcac gcaggtttcg 3855481 cgccatcagg atggtttgga tattatagcg gatttacaat gggtatgttc atgatcagca 3855541 tgatgcaccc atggggttac acctatcatc cagtcggagg ccccggttat gtttcttatg 3855601 gcgcttcacc cattgcctgg atcgttgata tcatcgcttt gattattatt ttaatcattg 3855661 tcatcgcatt gattcgcgca tttaaagcac cgaagacgta cagaaggaga ttttaggcaa 3855721 tgagattaat attaaatgag caagaaattg tagacggaat ttgcgtgtat atttccaatg 3855781 aagaagatat ctaccctgaa gacgttgaag taaaagaact atcgtacaac aagcgtacag 3855841 ggttcttcgc tgaagctaca tttggcctgc accacaagca gcttatgtca gatgacattt 3855901 cagaaggcat tattcagttc ttagaggaat accacaactt caatccggac gttaccgtcg 3855961 ttgaattgca atttgataag aaaaaaggct tctccgcctt ggtttttgtc aacgaagcag 3856021 aagaataaaa atgtcttaat caaaccttac tccgcgcggg taaggttttt ttaatggttt 3856081 ctctgagcat aaagttattt cgtttttcct aaactcagcg gatctgtgat catctctttt 3856141 ggctataaag tttccgtttt ttcaaaacaa atgtttcaaa tgagatagga aatgggtact 3856201 aatctattaa ctttgttaca tatttttaga tactcattgg ctcaacaact gaggaggaga 3856261 catttgtgaa gaaagacaca aggaaatata tgatctactt tttcggcgct ttagggggac 3856321 tgctatatgg ttacgataca ggtgttatct ccggagcact cctgtttatc aataacgata 3856381 ttcctttaac gacattgaca gaaggattgg ttgtcagcat gctgctcctt ggcgcgattt 3856441 tcggttctgc cttgagcggc acatgctcag accgctgggg caggagaaag gttgtatttg 3856501 tcctttccat catttttatt atcggtgcgc tcgcttgcgc attttctcaa acaatcggca 3856561 tgctgattgc atctagggtg atactcgggt tggccgtcgg cggttcaacg gcacttgtgc 3856621 ccgtgtatct ttccgaaatg gcaccgacga aaattcgcgg gacactcggc acaatgaaca 3856681 acttaatgat tgtcaccggg attttgctcg cctatatcgt taactacctg ttcacaccgt 3856741 ttgaagcgtg gcgctggatg gtcggtctgg ctgcagtgcc tgccgtgctt ctattaatcg 3856801 gcatcgcctt catgccggaa tcgccaagat ggctcgtgaa gcgcggcagc gaagaagaag 3856861 cgagacgcat catgaacatc actcatgacc ccaaagacat cgaaatggaa ttggcagaga 3856921 tgaagcaagg ggaagcggag aaaaaagaaa cgacacttgg cgtgctgaaa gccaagtgga 3856981 ttcgccctat gcttctgatt ggcgtcggcc ttgccatttt ccagcaggca gtcggcatta 3857041 acacggtcat ctactacgcg ccaaccattt ttacgaaggc cggtcttggc acatcagctt 3857101 cggcgctcgg cacaatggga atcggcatcc tcaacgtcat catgtgtatc actgccatga 3857161 tcttaattga ccgtgtcggc cgcaaaaaac ttctgatctg gggaagtgtc ggcatcacac 3857221 tgagccttgc tgctttatca ggcgtgctcc tgacactggg gctttccgca tcaacagcgt 3857281 ggatgacagt agtctttctc ggtgtctata tcgtctttta ccaggcgaca tggggtccgg 3857341 tagtgtgggt gctcatgcct gagctcttcc cgtccaaagc acgcggagcc gcgacagggt 3857401 tcacgacttt ggtgttatcg gcggctaacc tgatcgtgtc gcttgtcttc ccgctgatgc 3857461 taagcgcgat gggcatcgca tgggtcttta tggttttctc agtcatttgt cttctctcat 3857521 ttttcttcgc gttctacatg gtaccggaaa ccaaagggaa aagcttggag gaaattgaag 3857581 caagcctgaa aaaacggttt aaaaagaaga aaagcaccca aaaccaagtg ctgaatgagc 3857641 gtacattata aaaaaaggaa tcgtctcctt atgagacgat tcctttttct gtttacacca 3857701 tgaccttgca aatattgttc gtaaattcca cagggtcctg aatcggcagg ccttcgatga 3857761 ggagcgcctg attgtacaga aggtttgtgt acaggctcag cttctcttta tcttgttcaa 3857821 acgcgtcctg cagtgtttgg aatacctcgt gatttgggtt gatttccagc actttttccg 3857881 ccttcacatt ttggctgtca ggcatcgcat ttaagatttt ttccatctca attgtcactt 3857941 cgccgtcagc agcaaggcag actggatgtg atttaagccg ttttgagatt ctgacgtttt 3858001 tcactttgtc tgacagaatg tttttcattt cctcaaacag atccttatac ttgctttcct 3858061 cttcctcgga ctgcttttga tcctcatccg tgtctatgcc aaggtctccg cttgatacgg 3858121 acttgaattc tttttcctga taagaagcca gcattttaat tgcaaactca tcgatgtcct 3858181 cagtaaagta gaggatttca tagcctttgt ccgccaccat ttccgtttgc ggcagtttct 3858241 caatgcggtc gtaagaatca ccggtcgcgt aataaatgaa tttctgctcc tctggcattc 3858301 tggaaacata ctcgtctaag ctgaccagtt ttttctcttt tgaagagtag aataagagga 3858361 gatccttcaa ttgatcctta ttcgcgccaa aatcattgta cacgccgaat ttcagctgtc 3858421 tgccgaacga cttgtagaac gtctcgtatt tctcgcggtc ttttttcaac aggctttgca 3858481 gctcgctttt gattttcttg ctgatgtttt tcgcgatcag cttcagctgg cggtcatgct 3858541 gcagcatttc tctggaaata ttcagcgaca gatcctcaga atcgaccatg cccttcacaa 3858601 agctgaagtg gtccggtagc aggtctgcgc acttattcat gatcagcacg ccattggaat 3858661 acagctccaa gcctttctca tattccttgg aatagtagtc aaacggcatg ttttcaggga 3858721 cgaatagaat cgcgttgtag cgaaccgctc catccacgct gatatgaacg tgtgtcagcg 3858781 gtttatcaaa cccgtaatgc ttttcagcat agaatttttc ataatcctca tctgtcagct 3858841 cgcttttgtt ttttctccag atcggcacca tgctgttgac cgtctgctct tcctgcacct 3858901 cttcaaattc attttcgctg ccttccttcg gcttattaat ggttgtatcc attttgatcg 3858961 ggtagcgaat gaagtcggag tacttcttga tgatcgcttt taaacgatat tcctctaaaa 3859021 actcgtcata gctgtcatct tctgtgttct ctttgatttt caggataatg tctgtaccga 3859081 cagaatcctt ttcacacggc tcaatcgtat agccgtctgc acccgcagac tcccatttat 3859141 aagcctcttc gctgccaagc gctttactga tgactgtcac gacatcggca accataaatg 3859201 ccgcgtaaaa accgacaccg aactgcccga taatgtcatg tccgtctttc agctcgtttt 3859261 cctttttaaa cgcgagggaa ccgctttttg caattgttcc aagatgctgt tcaagctcat 3859321 cctttgtcat tccgatcccc gtatcagaga tggttaatgt tctcgcatct ttgtcagctg 3859381 cgacctttat gtagtaactg tctttatcaa acgtaagcgc atcgtccgta agcgctttgt 3859441 aatagatttt gtcaatcgca tcactcgaat tggagattaa ctcgcgcagg aaaatttctt 3859501 tttgggtata aatggagtta atcatcatat ccagcaagcg tttagactct gctttaaact 3859561 cttttttcgc cactcttgat cgctccttta ccattatgta aacccttttc agcatctatt 3859621 tatcacataa gatgacaatt gtcaattaga ttgatagatg catatatatg taaatttaac 3859681 attagttgga tttgttttca ctctttttct cactcattct cataaaaaag agaggcttca 3859741 tcatcctctc tttttttctg tgtcattcca acggccaaac tcccgcttca tccatatatg 3859801 caccgggtag aaaaacaaac cgaacggtat caaaaacaaa agattatgcc atgaagcatt 3859861 cagaaatgcg cttgcagtca ccgggaacgt aatctcttgc aataaaaaag agatgacagt 3859921 cagcacaaca aatgcagatg gaatggtcac gatgcaataa aacttgagct ccttcttatg 3859981 ctgtaccttc aaacatacaa acctcccaac aatttctaat tcatcttaac atatgctggc 3860041 ctttcttttc tcgcatgttt atcactgcac atagcgggaa gacaaataga aaaaggaggt 3860101 ctcgtatcat gggaagactt gaaaacaaaa cagcagttat cacaggcgcc gcgacaggca 3860161 ttggtcaagc gacggcggag gtttttgcca atgaaggcgc gcgtgtgatc atcggagata 3860221 tcaataaaga tcaaatggaa gaaacagttg acgcaatcag aaaaaacgga ggacaggccg 3860281 aatcctttca cctcgatgtg tcagatgaaa acagtgtgaa agcatttgct gatcaaatca 3860341 aggatgcatg cggaacgatt gatattctgt ttaataatgc cggcgttgat caggaaggcg 3860401 gaaaggtgca cgaatatccg gttgacctgt ttgaccgcat tatcgccgtc gacctgcgcg 3860461 gcacattcct ttgcagcaaa tatttgattc cgctcatgct cgaaaatgga ggctccatca 3860521 tcaacacctc ctccatgtca ggccgtgccg cggaccttga ccgctccggc tacaacgccg 3860581 caaaaggcgg tatcaccaac ctgacaaagg caatggcaat cgactacgca cgaaacggca 3860641 tccgcgtcaa ttccatttca ccgggcacga tcgaaacacc gctgattgac aaattagcag 3860701 gcacaaaaga acaggaaatg ggcgaacaat tccgcgaagc caacaaatgg atcacgccgc 3860761 tcggacgtct tggccagccc aaagaaatgg caacagtggc actgttcctc gcatcagacg 3860821 acagctcata cgtcacagga gaagacatca ccgcagacgg cggcatcatg gcgtacacat 3860881 ggcctgggaa gatgctgatt gaggagaaat ggaaggaaga aacgaaataa gagagggagc 3860941 cccctctctt tttgtctttt aaagcaatac aaccttatat ttcttcacat ccaaaaactg 3861001 caaaaactcc ctcgccagca cttcaggcgg atgcgccttt ccttcatcca gccgatacaa 3861061 aagcaacccg ataatcattg cggatacata atgggcataa agctttttct ctgcgtgaat 3861121 atcagtttgc tgatgcagat aaaacgattc cagcgctttg aacatatcag gtatcacatg 3861181 aggaacaccc cattcccgat tgagaaaatg gacaatgggc atgtttgaca aagcagaaag 3861241 cagaatggcg agcgccttct ccgcttcctt taaggaaaat tcattcgggc tggaggcaat 3861301 cgtcaggtga tcaatgatct ccgcacatga tcgctgtatc atggtttgga gcaattcctc 3861361 cttattggca tagtgatcat aaaaggttgc acggcggata ttgcttttac gcgtaatatc 3861421 tgaaatcgtg atgcccgcgt agtcttgttt ctccgccaat acatccagaa atgccttctg 3861481 cagcgcctct ctcgttcgaa ccacccgcct gtcgatttgc ttctccttct ctcgctctcc 3861541 tggcacagct tttccaaaca gccaataaaa ccgcttttga gaaacaagct cccatacctt 3861601 ctggctgatg gcttcaggag acgcggccgc atcctcattc agccaataca ggataatcgc 3861661 gtacgtgtac aaggcccgat aatgtccata aatgtcccgt tcaatcggcg ttaaattcac 3861721 atggatcgga gccagcagca catcctgctg aaacacatcc ttaaaaaaac gatgaaaatg 3861781 tcctctgttc atcatcacag aaaaaaagga acgatgctca tgaacaaagg acagcgtcgg 3861841 atgcaccgtt tgccgttttt tgttcaaatg aagggtatcc atatgactga aggcgtcaaa 3861901 aagcgctttg cccagtcctt ccttcatgtc ttcgatcaca tcctcaatga ttgaaaactt 3861961 atcctcataa taaaggtaga gcgatccgcg gctcactttg gccttctcag cgatttcttt 3862021 cattgtgatg tgttgaatat ctctatcttt caataaagcc agcagcgcct ctttcacttg 3862081 agcttcggca gattccggca caaaagacac ctccaatcat tagacagatc ttagatatat 3862141 gtacggtaac gtatagatgg ttcaccgttg tctttcttac agaaaaggta ccaccttata 3862201 ataggtccga gaaaagaaga aagcaaatga gggggatttt acaatggaac agcaagtaaa 3862261 ggacgacatc cagcgtgtct ttcagcttca gaaaaaacag caaaaagcct tgcgcgcttc 3862321 aacagcggaa cagcggagag aaaagcttca acgcttttta gattccgtca tcgcccatga 3862381 agaagaaatc atcgaagcga tccgcaaaga cgtccgcaaa ccatatcacg aagtcaaaaa 3862441 agcggaaatc gaaggaacaa aaaaagcgat tagagataat atgaataacc tggaacaatg 3862501 gatggcgcct aaagaagtcg gttcatcgtt aagccctgac gcaaacggaa ttcttatgta 3862561 cgagcctaaa ggcgtcacac tcatcctcgg cccgtggaac tatccgttta tgctgacgat 3862621 ggcgccgctt gccgcttctc tcgcagccgg aaacagcgcg attgtgaagc tgtccgattt 3862681 cacgatgaac acgagcaaca ttgctgctaa agtaataaga gacgcttttg atgaaaaaga 3862741 agtcgcgatt tttgaaggag aggttgaggt ggcaaccgaa ctacttgatc agccgttcga 3862801 ccatattttc ttcactggaa gcacaaatgt cgggaaaatt gtcatgacag cggctgccaa 3862861 acacttggca tctgtcacac ttgagcttgg cggcaagagc ccgacgatca ttgacagtga 3862921 atacgatctg atggacgcag cgaaaaagat cgccgtcggg aaattcgtaa acgccggcca 3862981 aacctgcatc gcacctgatt acctgttcat taaaaaagac gttcaggaca ggttcgcggg 3863041 gattttacaa acagtcgtca acgctggatt tatggaggat gatcataccc cagaccgcag 3863101 caaatttacg cagatcgtca atgaccgcaa cttcaaccgc gtcaaagatc tgttcgacga 3863161 tgccatcgaa agaggggcgg aagtggtgtt cggcggcgta ttcgatgcca gcgaccgcac 3863221 gatctcgcca accgttttga aaaacgtcac gcctgacatg aaaatcatgc aggaggaaat 3863281 cttcgcatcg atcctgccaa tgatgaacta tgaagacatc gacgaggtca tcgattacgt 3863341 aaatgaccgc gataaaccgc ttgcacttta tgtgttcagc aaaaaccaag atctgattga 3863401 caacgtcctt cagcacacga catcaggaaa tgccgccatc aatgatgtcg tcgtccattt 3863461 cagtgacgtc aacctgccat tcggcggcgt caacacaagc ggaatcggct cctatcatgg 3863521 ggtatacgga ttcaaagagt tttctcatga gaagggtgta tttattcagg ccgctgaata 3863581 atcgcatgat caaaaggcgc ttccttagag gagcgccttt tattgtaact ccttgaccaa 3863641 aagcaattca tcacggatag gtattttatt atctgccagt aaaggaattt cgggcttcat 3863701 ctttctggcc gtctcgactg cattcacaaa tagtcgatcc aaccggtacc ctctcttctg 3863761 ataaaacgct aatgcatgaa tattatcatt ggttgtgatc agttttattt gtttgatatt 3863821 tctctctctg catgcttcct cggctttctc tagcagagct gttccgatcc ctttattctc 3863881 aatgacacta tccagcgaaa tgatttcaca ggcatcttct tcaaatatgt atgtaataag 3863941 gccaacaatc tggttatcat cgttgagcat tccataacca tctaattcat cgcagttata 3864001 aataccgcta gaaataacca tttgcggact gccccagtgt ttttgaaaaa acgcggaaac 3864061 aagatcttta ggtacctggc atgtcggaat aatattcata ttttcctcct tttagctgaa 3864121 caaaaataag agaattaaca acctatttta tgtcattaat ccccttatct agtatttact 3864181 agaacttata acttgtcaaa agctgtctga ataccaattg cgtggattga taaggatcaa 3864241 aatctgaatc ctgagattgg aagatttgct ctggggtcaa tgtctctgcg ttctctgata 3864301 acgtttgaat cagactttcc aaatatccat ttaactctga tttggacgat tcatgtaggg 3864361 attgatgatt tacagcgagt tctctaaatc tgttatcact gattaatttt tttcgaagag 3864421 ctgctagcat caagtcaagc catgcaggct ggccaaatgt aatatttaaa gctaacgttg 3864481 cttgatcaga tttggtggag tgccataaac ctcttggcaa atacagcatg gttcccggtg 3864541 ttaaattaac gatttctgca tctggcagat cctcttttgg cggatctcct ttccaatatg 3864601 actgtaaatc atcaggatag taaggagcct ctgataaatc atagtgctgc attggattgc 3864661 tcacattttc attcttggca agcttccatg ttttctcacc ttgaatttga aaaatcaagt 3864721 tggtgtaggc gtcaaaatgg gctttgaatc ccccgccatt tttcgccgcg taaacaatgg 3864781 ctttggaaga agtacccgca ggcagtctta attccgcttt gagtttttct atccaccttc 3864841 tgacttgggg aataaatagg tcggtgaaat caaactctaa tgcagcccct ttttcatacc 3864901 actctaaagc ctctgcaggt gacacaagaa atctgtctgt gatcccttca gattcttcaa 3864961 tcacagcatc accaacgacc atgactggat tattgtagat agccaatacg ttttctagcg 3865021 ttctaacctt ttcaaacccc ggtatgcttg taaatctctc cacttctcct ctggctacca 3865081 aaggttttac aggccaatat tcttctaaaa actcactcat cgttacagga ctgatgatag 3865141 actccaaaac cgattcggtt acagcactca tattatccct cccaaaaaaa gtaacttcac 3865201 cacaaagata taacattttt ttctaaaagt aaatattgac agaattatca gaggattata 3865261 atatttagtt gtgcgtgata gcctattttt ttacaaggaa ggagggaaaa ggatgaaaaa 3865321 ggcttataag aaacctcgtc tttttgaact gcgccgtgct gtagcagctg gcggccatta 3865381 atctcatata gcatttgaca tctagtactc tattttagga gggatgctca atgaaaaaag 3865441 cttataagaa acctcgcctt tttgaactgc gccgtgctgt agcagctggc ggccattaat 3865501 ctcatatagc atttgacatc tagtactcta ttttaggagg gatgctcaat gaaaaaagct 3865561 tataagaaac ctcgcctttt tgaattgcgc cgcgctgtag cagctggcgg tcattaatct 3865621 tatccaaaac gattaacgtt tgaggctatc acgccaactt gataaggagg atgctgaaga 3865681 tgattacggc tgaagaatgc agaacgtaca aagaatttgt tgatctttac caatcctatc 3865741 tttacccctt gcttggcgcc agactgtccc ggatgtattc ccccaaaaac aaagtcatta 3865801 tcgatatggg cacaggtcca ggttatttaa gcattcagtt ggctaaaaga acaaatgcgc 3865861 acgtgcatgc tgtcgatatt aacccggcca tgcatgaaat cgctcaagaa gaagctaaaa 3865921 aaagcggagt aagcagcctg atttcatttg atttggaaga tgtccaccat ttatcttacg 3865981 ctgaccaata tgctgacttc atcgtctcct actcttgcct gcatcattgg gaagacgttg 3866041 ttaaaggact taaagagtgc tatagagttc tggctccggg cggaaaaatt gtcattttgg 3866101 atacatttaa tccccaagga agccatttag agattatgcg aaaacaaatc aaagaaccgg 3866161 aatacttcag gtttgtaaga gaggcatttg aagaaagtta ttcctttgaa gacattcacc 3866221 agtttgttca ggatgccggc attcccaatt attcattaga aacctttcac tttttaccgg 3866281 aggattttat agaaagctta gatgagctgg aggatgctcc cctgtgggaa caaaatgatc 3866341 aaagtactga tcatgaaatt gagtctgtca catggatgtt aacgatagaa aaagaaaagg 3866401 aaggtgcatt gtaatgatca atgaatcaac tgttttatcc aaaaatccag aaatgccatc 3866461 aagaaaatat ttgaaaagca ttattataga gccgggcatc actttaaatg aaatggcatc 3866521 agatatttat aaccatatcg acggcaaggt cagcatacat gatatttgct caaaaatcgt 3866581 caatgaatat gatgttgatt atcaaacctg cttagaagat tgtatggagc tgtttgagtt 3866641 gcttattgat catgaagcaa tcaaagttaa gcagggggca tgagaattgg aaaaacaaaa 3866701 agtgcttgct ttaccagacg atgtacatga gctgagtaca caccgttcta aatcaatcgt 3866761 aaattacatc atcactctgc ttgcctttgc caaaaaacaa ggattgactc atcaagatat 3866821 tgtaagctgg attcacgagc aatatgagga aagaggatat tatgatgagt ggagacacat 3866881 taacagccaa caaccagttg gatcatttgt ggaactcttt ataaaaggaa gacgtttact 3866941 ttatgacaaa attgaattgt ttgaaacaga agataaatat gtcgtaaata cccacacttg 3867001 gtatgaaaaa gaacctagtg aggccttttt ttattttgaa attgatcccg aagaattttc 3867061 tgcgtacgct tccattctcg caatcgaaaa cgcaaaacgt ctcggaatta aaatcgatat 3867121 tgtaaaagaa acagatgtag agacagctta tatctataaa catcaataac gctattggga 3867181 gggagacata tgtgcgggct cgcgggtatt ataaatctgg ctgctccccg ttctcaggaa 3867241 tgtacctttc atatattgaa aggcatggca gatgccatca gctatagggg accggatgat 3867301 gaacaatatc atattgattc caaagtcggc tttgcatttc ggcgattgtc cattcttgac 3867361 cttgtaaatg gacagcagcc ctttttaaat gaggatggat caatcgtcgt tatggtaaat 3867421 ggagaaattt ataactataa agaactgaag gcttctttac acaatcatat gtttaaaacg 3867481 acatctgatt gtgaagtaat tgttcattta tatgaagaaa aagggattgg atttgtagac 3867541 gacatcatcg gaatgttttc aatagccatt tgggacaaaa ataaaaacaa agtattttta 3867601 gttcgtgacc gctttgggat taaaccgctt ttttacacag agctaaaaca cgagcttata 3867661 tttgcctctg aaataaaatc cctattttct catcctcact gtccccgcca atttaattgg 3867721 aaagaagcac tctcagacat ttggctaagc ggggaagcag ccagtaatca taaagaaacc 3867781 acttcctttt ttgtaaacat ccaaaatctc gatgctggcc attatctcga aattaatttg 3867841 acaacaaatg aacgaaaaac agcaagctat tggtctttac aggatatttt gctcaggcaa 3867901 ggctatcgtg agaatctcca tcccgatgac ctgattgaag gatatagaga actgctggca 3867961 gattcagtcc atagatgttt acaaagcgac gttgaagtcg ggttgtttct tagcggtggc 3868021 attgattcag ctgcagtcgc acattttgct gcagaaaaac aggatctcca tacgtttaca 3868081 gtattaagcc aaagtacatt tacaaatgaa gatgcaaaat atgcccattg gctggctaaa 3868141 gatttacacc ttccaaatca tcaggttctc tatcaattag ggaacgatga gttattacaa 3868201 ccagagtcat ataaacattt gttatggatc tgtgaaacac cgttttgcgg accggaacaa 3868261 ttatataagt ttcatttaca taagtatgcc aaagcgataa ggccaaacct gaaagtcatg 3868321 ctgaccggcc agggcagcga cgaatttaac ggcggttaca gcacgacact ttcaccagcc 3868381 gagaacccaa gttgggaagg atttattgaa tcggtcaata cgatggagat gaaccggctg 3868441 catcggctgc agggaaatat ctttagagtg tgggaggagc attttggact ttctcctata 3868501 aacctttctt atttaaagag caatgattcc agccaagcag atccttggca atcgtatgtc 3868561 ctgacaaaat accgtgatct gcaaatgtat aattgctggc atgaagatcg gatcgccgcg 3868621 gctaatcata tcgaaaaccg tgtaccgttc ttggaccatc ggcttgttga atgggtttgc 3868681 ggaatacctg atggactccg taaagacttg ttatgggata agtcggtatt gcgaaaatca 3868741 ttaacaaatg agctgcatac aagctatacc caccggccaa aggttccttt tttctatggt 3868801 aaggacgtga gatatacaca taaaatgatg tttcatcttc tgaagaaaaa caattatcag 3868861 cttatagagg aggccttctc tcacagcgat gcctccagca taatacaggt tgaacacatt 3868921 catgccatca tgacatattt ggaggatgat cctgagttta caaattttga atttttatta 3868981 agactggtga acatgggact tttatcaaaa atgactaaag aaaccccttc tgttcaatta 3869041 gacataacca gccatttaga atcgataaca ataaaagact ggcactcaca ggaaggtgat 3869101 attgccagtc gtttaaatat ctcagccaat aagtgtgaag gacaagatat tttggcgcta 3869161 aaccctggcg tcactctgtt aaggccggaa agcgatagtg agcattgcat ctacattgcg 3869221 gaagaaggat ttattcagtt tattgtttcg gaggaagacg tcggagcttg gctgcatatt 3869281 ctctgcgata ttaatggaaa agacacactt catacgattt tagacagaca tggtgtcagc 3869341 cttgaagaag tggccaaata tattcaagaa gccatcgaac acaatatcat tttgatcaaa 3869401 caaaaaaatc tgccagaagg agcatataga tgagcatctt ttattcgttt tccgcactta 3869461 ggggattagc aatggggatt ttttcgccta tttggattct ttatctgata tctaaagatt 3869521 atgatttcct tcagattgga ttaatgggag cggtacttga aattgctaag cttatatttg 3869581 aagttccttc cggcgttttt gctgatcgtt atggaattaa aatttcaatt gccagttcat 3869641 tctttttctc catccttaca tgggccttct tcccttttat cgattcagct gctatttgca 3869701 tactggctat gatcatatgg gctttatcag attccttaat ttccggttct tttgaaactt 3869761 ggatgagccg tgtcgcaggg gaagatcgat tcggcaaaga aatgatgaaa aacacacaat 3869821 tgctaatcac ttttttaatt attggaagta ttgccagcgg gtatttgtat tcattaaata 3869881 tctattttcc tttcctgctc gttatggtga tctacttatt actatttatt tggatgtctg 3869941 tatttattaa agtcccttct gtttccgaaa caaatcatgg ggatcagaac caacatgatt 3870001 cgataaagat tatcaaagaa agtttaaaaa ttatctttaa caaaaaaagg gttcttttaa 3870061 tcgtcatagc cggtttcttt acagccacag cctatgacac aatttcccgt tactggcagc 3870121 cttttttgag tgatttaggc ttttcagaaa agtcactggg atatattttt gccctaggag 3870181 ggtttaccgc tctcgttctt ttgacattaa ccatcaggtt cgaaaagaag atcgaaaaaa 3870241 atccatatct cgctttaacc tcattggatt ccatgggcat ggtcatgact tttctattgt 3870301 ctagagcatt caggccgctg ggcattccat gtacagcgtt tttgcttgca attgaagata 3870361 ttcatcatcc gatcgtaaca agttacttaa ataagttttt ccccgattca tacaagaaca 3870421 cacttttctc gttaaactca ggggtaggag caattggaga aattctttcc ggtgtcattt 3870481 tcggcatcat ttccgcagcc tttgggctct ctgccatgtt tgttgttgta gctgtatttc 3870541 tattaatccc tattatcctt tatacgatag tgcctaagat taaagacaat gatatgaaag 3870601 ttcagattga aaaatcccag caagtgtaaa tgttttgtat cacagtaaga agaccttctt 3870661 attaaaagaa ggtcttctgc tattctattc agttatttcc caaaagccat cagcttcgta 3870721 taacttccaa tataaagtgt tccgtcctca gcgagctgag gagaagacac gacgttgctg 3870781 tcggtttgat agctccataa ttcattgccg tttgcgtctg ccgcataaac cttcatatca 3870841 tctgacccga aataaaccgt tcccttcgcg tcaatcagcg gcgccgttct gacagggccg 3870901 tctgtgtaga atgaccagtt catatccccg tttttgctga tggaaaacag ctcgccgctt 3870961 cctgagccga tgtagatatt gccattatga tcaatcgcag gagatgagct ggagaacccg 3871021 tttagcggga atgtccattt caaactgcct gttgatgtat aagcatacag ctgtccatct 3871081 tggttgccgg cataaatgtt tccgtcctta tcaatcaccg gatatccttt aaacgcattt 3871141 gacgtcgttc tggaccattt cacctgtccg gttccggagt tgatcgcata aaacacgtaa 3871201 ttatatgtgc cgacatacac ggtgccgttt ttggcaagca ccggcacaga gctgacgacc 3871261 ccatttgttt tcaacttcca gcgctctgtc caggttgatt ttgacgtcgg tttgatcgcg 3871321 tgaacataat tatcaagtgt tgagaaatac aacgtcccgt ctgaaccgat caccgtttca 3871381 gagcttggcc cgccgcttaa cggaaccgtt gttaaaattt ctcccgtttc tttgtcaata 3871441 aaataaatct ttttgtcata ggatgccaaa tagataacgc cgttggtccc aagtacagga 3871501 gattgcgtat atgtttttcc aagattgccc gtcacccatt tgactgagcc gtctggatta 3871561 aaggctttca tttccccgtc tctggaatga agatatactg tgccgtctcc gtcaatcaca 3871621 gcccccgctc cattttgcgg agtcgttctg atgtcgtttt gccatttcag cgtcccgtct 3871681 gtatttccgg cgaaccggct ttcgcgtgac cagttaaaca tggcaggcgc catcgcttgt 3871741 acatcatatc ttcctggcaa aaagccagat gctccattat tttgagaaaa caccgtttcc 3871801 gccgcataag cagctgtcgg ctgaagcact ttggcagcgg gcacatcaga aacagcgccg 3871861 gccgaaacag ccgccgccac cgcagctccc gcaatcaaag ctttcatacg aaatgacttg 3871921 accatcattg agacccccat tatatgtaac ttctaatttg tgaccatcat aacatattca 3871981 tccattttat aaatctattt cacaaaaaca tcacaaacta gaaaactatg taagagtatt 3872041 cacggacgtt ttttcagcac ccgatcgaaa tgcagccaca aaccaaatga cgttgacagc 3872101 agccgcagcg agactaactc ccaaaacaaa gatcacctca gaaagcagat ggtcactaaa 3872161 gaaactaaac atcaagataa aaccggccga agacaaatga atcaaaagcc cgaagccgca 3872221 aagcaccgcc atgacatacc tcattgcatc gactccgagc atataaacga gaaatggaat 3872281 gaaatacaag acaaggatca taccgacagc tgaccacatg ccagctgaat taaactgatt 3872341 ggccgccgct cccgttccgg ccagcggcga aagtgaagcc gccacaatca cggcgcaaaa 3872401 aagaaacgca gaaatggttg tcatgatcgc cacgctattt ttttttgaca tcaaactcct 3872461 cctttaatag aaatattaac cttttttatt ataagtaagt tgaatgttat attcattata 3872521 tttttaaaaa attccagaat acatacacaa atgctatgct tctttctagt atatttatat 3872581 agtaaaaaac aaaggataaa agactcattt ttctgtaata tcaggatttt atcaccatac 3872641 catattgcat gtacatgttt ttcaaagtat actattccag attaattcag aggagagaga 3872701 aaaatacatg gaaaaaccag caggattttg gattcgtttt ttagcttatt ttattgacgg 3872761 cattattgta tctgttccta gttatattat tctatttatt atcaattctg tgtttgtagc 3872821 tggggctgtg gcaacaaacc cttacatgac ggaagaagag tatttagtga aatacatgac 3872881 gcttgcattt ttgcctacta tgctgatcat gatcgtcatc agcgtgttat attacgggct 3872941 gctcacagct tctaaaatgc aaggcacact tggcaaaaaa attcttggcc tgaaagtggt 3873001 caatgaacaa ggtgaacggg tttctgtcgg acagggaatt ggccgttact ttgcctatat 3873061 cttatctgga atcatctttt atatcgggtt tatcatgatc gcctttggag agaaaaaagg 3873121 cctgcatgac atcatttgca aaacacgtgt cgtgtataaa taatagaaaa aagtctagac 3873181 gccaataggc atctagactt ttgttttctt tgcaataggc tgccacgaca gatacgtagc 3873241 gcttctccac aaccactcaa acggccccat ccgaaagaca cgaagccaaa ggtggctgaa 3873301 gaccatttga acggcacaaa cagcaattgt aatgagcaca ccggcagcag ggtacacttt 3873361 tccatacagg cccaagccgt aatgataaaa aatccaagta cacacaatag actgcatcaa 3873421 ataattggta aatgccatcc tcccaacagc ggagaatgat tgcagcactg ttctcactct 3873481 tgttttatga taaagataga caaccgttgt aacatagaaa aacatgagga aaggcgcgcc 3873541 aatcagcaaa catatttctt tatccgttac actgtacagc acctgggcgc cgatgccgat 3873601 gacaagccca gccatccata atcgttttaa tcctttgcga tgcttttccg gttcatgcaa 3873661 ataccgtgat tttgctgccg cagctcccag caaaaacatg ctgaaatatg gaatggatgc 3873721 aaagaagtag ttgagcggat tatacgtaag catgccattc gaagacatgt aaacaagacg 3873781 gtcgtggatc cgctgttctg caatatcctt caggctgccg cttccataaa catgaatcgc 3873841 ttgttttgcc tgctgtgtta ccgcttgtac ccattcctgt ccgtttgatt gatcaaaact 3873901 tgtcaacatg aacggaatgg aaaacagaag atacaaagag accgcccata tcagcagtgt 3873961 tttcggcttt gcttttcgaa acaagagcag gacaaatccg agcagggcat attctgttaa 3874021 aatatccccg tcccatatca aaaaggcatg aatcgttcca aacaagagaa gcgccattaa 3874081 ccttctcaca tataacggaa caaaccgttt ccctttgttt tctgctctct ccatcatgac 3874141 aaccatgcca aatccaaata aaaaggaaaa caataaaata cattttgttt gaatgaagaa 3874201 tttcagtatg tctgcggcgg caaaatcagc ttcagaccac ttatccatga aaaaattctc 3874261 ttttccaagc atagacaaat acatatccgg ataactgaaa tgtgccagat tgacaaataa 3874321 gatgccgaaa atcgccattc ctctcagcac atcaagcaca ccgatccgct catttgttaa 3874381 agtcggctgt aatgaagaca tagccatcac gctccttttt tctgtacctt aagggtagga 3874441 aaaaatgaag cgcggtaaca tcgatttagg tgtcaggccg gcatgaaaac cttacaatct 3874501 tgtcatcttt atggtttcat cacctttaaa tctaatgctt cgatattctg caaaatgcga 3874561 tcaaagcgca aagcctgagg ctcacatggg aagatgtggc cttcatacgg gtcgcctaac 3874621 gtccggaaaa acggttcaaa taaaccagga accaatacgc ccaccatctt tgtatagtga 3874681 gaatcaaggc gataggagtg aacggtattt gcagggacat gcaggaaatc tcccggattc 3874741 agctgaattt cctggccatc tgtccacatc gtcatctggc cttcaaggca ataaaatgtt 3874801 tctgtatgat attcatggta gtgatcaacg attcggtcac ctttagggcc ttcagatgat 3874861 acgacgataa actggccatc tgtatttttt tgtgcagcca caatgcggtg aagctgatct 3874921 ccagtcaaca gacgatctcc ttctccagat tcaagaacgt atggaaccgc tccatctggc 3874981 agctctgtaa gttccgctaa tttggccgaa catgcaggct ttgcttcatc tagaaataca 3875041 atgtccgcta cagcggctgc ttctgcaaat cgctcgtttg agacttcttc gcttgcgtac 3875101 ggcggatgtt cagcgtgatc atacggattc ccaataacgg aatacaagtg cgctacgttt 3875161 cctttcatcg tgtaagacac cagtcttgtt ctgtggctct gcatccggta gctgtgcggt 3875221 gttcccgccg gaatgttggc ataatcacct gatattaata aatagcgttc accatcaagt 3875281 gtcagttcca gtttcccgtc caaaacgaga attccttcat gtgtgtcctt gtggacgtga 3875341 agcggaaagg catctccttt tcccccggaa agaagcacga tctcaaacaa atcacctgtg 3875401 ctcctcccat tcgccatcac cgtggcaacc tgtctgccga acagatagcg ctcgccttct 3875461 ccgctccgga gcaaataagg cattttttct ttaggcaatg aatgtgtaca taatgttttc 3875521 atattatcgc ttcctccaat ttagaccagt ctatatatta tcattcattt gtctagaccg 3875581 ttctatataa ttgtaggaga aaggataaca aaatgctacc ctttttttct caccagcact 3875641 ggtatttgtt cggcaatgag aagaagaggc gttttgtctt tattcgttaa cgaaagcatg 3875701 atgccgccct caatcatcga attaatcagc gttccaagct gatttgcttc ttcttctgca 3875761 aatccgtttt ccattaattt tctggcaaaa accgcttccc agcttttaaa caccttcatg 3875821 caaaccgtcc gcagcggttc actgattaac gctgtctcac tcgccagcaa accgactgga 3875881 atacctttaa tgctttctgt gttgtcaaat tggctggctg tttttttgat aaaaagctga 3875941 atcgcttcaa caggatcaga ggattcatcc atgctttgct gtatcagatg ttcaacgatc 3876001 ttacctgtat atgtaaccgc ttcaattgct agttcttctt tgccattcgg aaaaaagtga 3876061 taaagcgatc cttttggagc accgctttct tttacaatct ggttcaaacc tgtcgcgtga 3876121 tatccttgca gctggaacag acgtgacgcc gtgtgaagga ttttttcacg tgaatctcct 3876181 ctgctagtca ttaaaacatt ccctcctagg tatggtagag cgacttatat aatataaaaa 3876241 agaaccctgt gattgtcaaa aggggtaaga cccttccgga tggggtaatg tacaaaaaca 3876301 gcgtctagga gggatctctc aatgacaatc gatcattcag tcacaaatac agagcagctt 3876361 gaacaacaga accccgccat aaaaacaaag ctcaaactga aaaagcttaa ggatcaggtg 3876421 atcgtcatta ccggcgcttc aagcggtatc ggacttgtca cggcgagaat ggcagctgaa 3876481 aaaggcgcaa aggtcgtggc agcagcgcga aatgaagagg cgctgaagga gctcactgat 3876541 gaacttaagg aaaaagggca cgacgccata tgggtaaagg cggatgtcgg aaaagaagag 3876601 gacgtcaacc gcatcgcaga aaccgcgatc agcacattcg gccgctttga tacatgggtc 3876661 aacaatgcgg ccgtctcgac tttcggacac gccatggacg tcaccgtcga agacatgaag 3876721 cgcatgttcg acacaaattt ctggggacct gtttacggaa caagagcggc tgtcaaacac 3876781 tacaccggca gaggtgtgcc gggcgcactc attaatgtag gaagcctgtt cggagacagg 3876841 ggaacggtca ttcaatccac atatgcatct gccaaatttg cgcttcacgg ctggacggaa 3876901 agcatccgaa tggagcttga aaaggaacag gcgcccgtct cggtaacgct catccacccg 3876961 ggcagaattg acacaccata taacgagcat gcgcacagct acctcgacaa acagccggct 3877021 cattaccgct ccatgatcta tccgccggaa gcggtcgccg aagcgatcct gtttgccgcc 3877081 gaacacccta agcgcgacat gtacatcggc tcacaggcca aagccatcgc catgctgggc 3877141 gcgctttttc ctcgtctgac cgacagactg atggaaaaaa tcatgtatca cagccagcat 3877201 gccgaaagac cgtccaatcc gagagaagaa agcgctcttt atgatgctgg ctgcggtatg 3877261 catgacagag gcacaaataa aggatggatg aggtcaagaa gctactacac aaaagcgacg 3877321 aagcgcccaa ttgtatcggc ggctgttgtt gccggactag tggcttgggc tgccgccaaa 3877381 cgatgcagat aatctctgac cataagaaaa acccatgctg ttccagcgaa ccatgggttt 3877441 ttcagctgtt aatcgataaa agccttgttc atacgctgca gcagctcgcc gaacatctct 3877501 ttttcctgtg ttgaccattc tttcagcatc tgttcataac gttcaaggcg cttttgctga 3877561 tcggctttta atagttgttt gccgagtttt gtaatggtaa acaggctgac tctcccatca 3877621 gacgggtctg agaaacgata gatgagctcc tttgcctcta atgcagctgc ttgtcttgaa 3877681 agagtagaaa tatcaagctt aaacgattca gccaattcct taacacgagc aggcccaaac 3877741 tcatccaatt gtctcagtaa taagtacgaa gatctctcca aattccctgt tcttttctcc 3877801 gattgatcca gataaacagc tctcctgata aaagtcgtca gctcatattc aattaattca 3877861 actggatttt gattttgcaa tcgctctcgc tccctattcc aatctccggc attgacaaca 3877921 tcatatatac ttgtataata caaatgtaca ttaactgaat aaatacaagt cgttatatga 3877981 ctaaatcaat tattatactt gtatagtaca atcatataaa aagaaagtaa agcgattcct 3878041 cagaaccatc ctagaagcaa gcaccagaaa ggaggaagct gttctgattg gagagcagca 3878101 cttgatgtga aagtcatacg aattattttg caagtgttga tattatatgt attttttatg 3878161 atcggggaag ccattcagca tctgtttcat ttacccgtgt caggaagcat cgttggattg 3878221 gtattgcttc tgatctgctt gggcctccgt attgttcccg tctccatcat tgaagacgga 3878281 gcagggtttt tattatcctt ccttccattg ttgttcatcc cggcaatgac aggagtgata 3878341 aactatccgt ctctcatttc attcaatggc ctgatgctgc tgattacagt cgttctcagc 3878401 accatcgtca cgatcattgc ggctggattc gccagccagc tattagagaa aaaagcaaaa 3878461 aaacgggagg agaaagagaa atgcagcaag catgtatcgc gatcattata attcttttaa 3878521 cagttgccgc ttatttagcg atggtcaaac tctataagcg attcccgctt ccatttctga 3878581 tccctgttct gacaacgaca attttgattg tagcggcttt gatgatgttt catgtttcct 3878641 atgaaggcta tatgatcggg gggaaatgga tcaattcttt gcttgggccg gctgttgtgg 3878701 cgctggccta tccgctttat aagcaatggc atatcattgt caaacattgt gttcccattt 3878761 taggcggcgt cctggtcggc ttatgcatgg gaatgatcag cgggctgatc ttcgcagaag 3878821 cattcgggat tgatcatgat ctcttattat ccattctgcc aaaatcgatc acaacccctg 3878881 tcgctattca gatcgccgcc ggtcttggcg gcgtcccttc catgacagtc gtatttgtca 3878941 tgattgcggg cttttcaggc gtcatcctcg ggccgctttt cctaaaatgg cttcgcatac 3879001 gcagctccct aggacaaggc attgcattag gcagcgcctc ccatgcactg ggtacctcca 3879061 aagcgttgga atatggggaa ttggccgtat ccatgagttc cgtctccatg acgctttgtg 3879121 cggtgctcgg ctcattcttc ggcccgctcg tcgtctggct gtttcatatt taacaaagaa 3879181 agactgcccc gggggagggc agtctttttc gtttaagaag caaaaaaatc aatcaacggc 3879241 tgaaagtcct tagataaatc aacgtcattc ggttctgctt gaagcaggcg gtcaatcata 3879301 cgctccagct cctcaacatc attcttatcc gtatattcaa tgaagtttaa gctttcaagc 3879361 caatcccgat atgaatgttt ggctttgcca tagctgtttc caaagacaag gcaaggtgtt 3879421 ttggtgataa tcgagaaaat catcgcgtga aggcggtcgg taatcaccaa tttactggag 3879481 ccgatgcggt ccagcatctc cataaaatgc ttttcacgat cagcgtaatc gatggtgtct 3879541 accgtatcca gcaccgtatc ggtacgctct gtgtaagttg ttttttctgc ccattgcttc 3879601 atctgtgaaa taaaatcttc gtcagtcact ttctccttat ccgctcttaa aataaagaga 3879661 acgccgtccc gctcgagctc tcgcggcaca atatccaagg aaagcaccat gtccggtgta 3879721 aagatcacat tggagttgaa ggtctctttc acaacatcca gtgtttgcgt ctcacgcgca 3879781 gcaatcgtta agtttgtatt ttgatggtac gcatcctgtg tttttttctt ttccttctgt 3879841 ccttcctctg tatcctcaaa ataaacggat tgtggcagag aaattgattt gtagtcttta 3879901 aacgccgaaa agacctttct tctgtcttcc tcaatatcga gataaaggtt tcctaaattc 3879961 cctccgcctg taaagcagac aatatcgtct tcacgaatga tctccttcac cagttcaatg 3880021 ccctcatccg tcgcataatc cataatctca atgtattcat aatacggaaa atgatttttg 3880081 ataaatttct cttccgcata cgcaatcgct tggtcgccaa tgtttgtgta gctaggggaa 3880141 ccaaacaaaa atacttttcg tttatcattt aacagagctt ccggctccac atttggcgca 3880201 atgcctttta ctagtttttt gcctttgatt tcttgtacag tcatatctgc gtcctccttc 3880261 tgggatgaat tcctcattgt gtgttaactg tctctaccca aaaagaagga tggctatgca 3880321 ttggcatgtg catcggctat atcagaaaca tcgttttcgc caatttgata gacgctgcaa 3880381 tgtcccgcgc cgttctttcc atatattccg cggcatgttc aaacgcgtct tctagtggca 3880441 cggctccggg gacgatgctg aaaagcgcat cgattccgtg ttgatagacg gcattactgt 3880501 ctcgggaaat tgatcccgca atgccgataa cgggcacatc gtatgattta gcggccttgg 3880561 ccaccccgat cggtgttttt ccatgaaccg tttggctgtc gattcgtccc tcgccggtaa 3880621 tcacaaggtc tgcatcctga acgatacttt caaaatcaac cgcttcaagg acaatatcaa 3880681 tgcctctttt caggtcagcc tgaagataag ttagcaggct ccatccaaga ccgcccgctg 3880741 caccggcgcc ctctgtatct cggaaggttg atccgagcgc tttttctgcc atatcagcga 3880801 aatggcttac gttctggtct agtacatcca acatgtcggc cgtcgcgcct ttttgcggcc 3880861 cgaaaacagc cgtagcaccc tttggtcctg ttaacggatt gtccacgtca caggcaactt 3880921 ccagtttgac attccgcaat ctggaatcaa gcccgctcac atctattgat gcaagctgag 3880981 ataacgcgcc gccccctggg ccaatctcgc tgcctgagtt atcaagaagc cttccgccca 3881041 atgcctgaat catcccggct cccccgtcgt tcgtggcgct tccgccgatt ccgatgatca 3881101 atcgctccgc tcccgcatca agagctgctc cgattaattc tcccgttccc cttgttgtag 3881161 tgatgagcgg atttcgctta tctacaggca ccagatgcag ccctgaagca gcagccattt 3881221 caatcacagc tgttctccca tctcccatca tgccaaagaa agctctcacc ggttccccca 3881281 gcggccctgt gacaacttgc tctatgatcc ttccattggt cgcatcgacc agagattgaa 3881341 cggttccctc gccgccatcc gccaccggca attttctgta atcagcaccc ggaaagaccg 3881401 atttgaaacc tctttctatc gcttcggctg cctccagagc tgataagctt tccttaaaag 3881461 aatcaggtgc aatgatgatt ttcatccaaa tcgcctcttt caaaacatga ttcacttaac 3881521 ctattgatct ccaatgtacc ataattgatc tggaaataca taccatgcaa tatggtaaaa 3881581 atttaaataa aaattagaaa tgaaagtgtt tgcataaaag aaatattcac gttatcatac 3881641 ttgtatacaa gtatactcct tgagtgagga aggtgagtgt atgctagact ccaaagacct 3881701 gttgtatccc gcaaaatggc tctcaaaagc gtcaaccgga gttcgtgtcg catacgagct 3881761 gagaatgcgg atcgtttcag gtctgattga aagcggtacc attttatcag aaaatacaat 3881821 cgccgccgag ttttcagtaa gccgttcgcc ggttcgcgaa gcgctaaaaa tactcgcatc 3881881 cgaaaaaatc atccgcttag aacgaatggg agcggtcgta attggtttaa ctgagaagaa 3881941 aatcgcggaa atttatgatg tgcggttact attagaaaca tttgtctttg aacggcttgt 3882001 caaaatagac attgagcctt tagttaagga tctcagcaaa attcttgaaa tgatgaaagt 3882061 ctcaatcaaa tatgaggatg ctgacgaatt ttcatttcaa gatgtgctgt tccatgaaac 3882121 gattatccga gcgattgatc attcatacat tcagatgatc tggaacaatc taaaacccgt 3882181 catggaaagc tttattcttt tatcgatgcg ggtacggtta aaggaaaagt atgaagactt 3882241 cacaaggatt ttagataacc acgagcttta tattcaagcc atcaaaacaa aggatagggc 3882301 gctgatgatt cagtctcttc accaaaactt tgatgatgtg caggataagg tagaagacct 3882361 atggctctca caacaaatgc tggcaaaagg agctgaatac aacaatgact agttatatgt 3882421 taggaatcga tatcggcacg acaagcacaa aagctgtgct gttcagtgaa aacggagatg 3882481 tggtacagaa agaaagcatc ggctacccgc tctatacacc ggacatctca acagctgaac 3882541 aaaatccgga agagattttt caggcagtca tccatacaac agcgagaatt acaaaacagc 3882601 atcccgaaaa acggatctct ttcatttcgt tcagcagcgc catgcacagc gtcattgcaa 3882661 tcgacgaaaa tgacaagccg ctgacgccat gcattacatg ggccgacaac agaagtgaag 3882721 gctgggcgca taagatcaaa gaggaattga acggacatga ggtgtacaaa cggacgggaa 3882781 caccgattca tccgatggca ccgttaagta aaattgcctg gatcacgaat gaaagaaaag 3882841 aaatcgcttc caaggcaaaa aaatatatcg gcatcaaaga atacattttt aaacagctgt 3882901 tcaatgagta tgtcatcgat tactcattgg catcagcgac aggcatgatg aacctgaagg 3882961 gcttggattg ggacgaagag gcactgcgca tcgcaggcat cacgccggat cacttatcca 3883021 aactcgtgcc gacaaccgag atctttcagc actgcagccc ggaaatagcg atccaaatgg 3883081 gaatcgatcc ggaaacgcct tttgtcatcg gcgccagcga cggcgtgctg tccaacctcg 3883141 gcgtcaacgc cattaaaaag ggtgaaatcg ccgtcaccat cggtacaagc ggtgccattc 3883201 ggacgattat tgacaagccg caaaccgatg aaaaagggag aattttttgc tatgccttga 3883261 cggacaagca ttgggttatt gggggacctg tgaacaatgg gggcatcgtc cttcgctgga 3883321 tcagagacga gtttgcctcc tccgaaatcg aaacagcgac acggctgggc attgatccat 3883381 atgacgtgct gacgaaaatt gcccaacgcg tcagacccgg ttctgacggt ctgctgttcc 3883441 acccatatct cgccggagaa cgcgctccgt tgtggaatcc ggatgtacgc ggctcatttt 3883501 tcggcttgac catgtcgcat aagaaagagc atatgatacg cgcggcattg gaaggcgtca 3883561 tttacaacct gtacacggtg ttcttggcgt taactgaatg catggatggc ccggtaaccc 3883621 gcatccaagc gacagggggt tttgcaaggt cggaggtttg gcgccaaatg atgtcggata 3883681 tcttcgaatc agaggttgtc gttccggaaa gctacgaaag ctcatgtctc ggcgcctgca 3883741 ttttaggcct gtatgcaaca ggaaaaatcg attctttcga cgccgtgtcc gatatgatcg 3883801 gcagcacata cagacatacg ccgatcgaag actcagccaa ggaatacaga acattaatgc 3883861 cgattttcat caatctatca agattattag aaaatcaata tacacaaatt gcagattatc 3883921 agaggggctt aatcacacac aaatagtaca tgacatgaag gggagggcat taccatgccg 3883981 ttaatcatcg ttgcacttgg gatcttagca ttactatttc tgattatggg cttaaaatta 3884041 aacacattta tttccctgct ggtcgtatcg ttcggcgtgg cactggcact cgggatgccg 3884101 ttcgataaag ttgtcagctc catcgaagca ggaatagggg ggactcttgg ccacatcgcg 3884161 ctcatcttcg gactcggtgc gatgctgggc aaactgatcg cggattcagg aggcgcacag 3884221 cgcattgcga tgacgctcgt caacaaattc ggtgagaaaa atattcaatg ggccgttgtc 3884281 attgcctcat tcattattgg gattgcgtta ttttttgaag taggactggt tctattaatt 3884341 ccgattgtct ttgcgatttc aagagaattg aagatttcta ttttatttct cggaatcccg 3884401 atggtcgcgg cactatccgt cacacacggt ttcctgccgc cgcacccggg acctacggcg 3884461 atcgccggtg agtatggcgc aaacattgga gaagtgctgc tgtacggctt tatcgttgct 3884521 gttccgacag tgctcattgc agggccgtta tttacaaagt tcgcgaaaaa aatcgttcct 3884581 gcatcatttg cgaaaaacgg caatattgca tcactcggca cacaaaaaac atttaacctt 3884641 gaagaaacac ccggctttgg aatcagtgtc tttactgcaa tgctcccgat tatcatcatg 3884701 tcggtcgcga ccattatcga cctgcttcaa gaaacaatcg ggtttgcaga taacggagtt 3884761 ttagctttta tcagattgat tggaaacgca tcgactgcta tgattatttc gttattggtc 3884821 gcagtctata caatgggcat caagcgcaac attccagtca aaaccgtgat ggattcttgt 3884881 tcaactgcca tttcacaaat cggcatgatg cttttgatca tcggaggagg cggcgccttc 3884941 aaacaagtgc tgatcaacgg cggtgtcggc gattacgtag cagacttatt caaaggaacg 3885001 gcattatcgc caatcattct ggcatggctc atcgcagcga tcctgcgcat ttctctagga 3885061 tcggcgactg ttgccgcact aagcacaaca ggtctggtca ttccgttatt gggccattct 3885121 gatgttaacc tggcgttagt cgtactcgca acaggagccg gaagtgtcat cgcttcacac 3885181 gtcaatgacg ccggcttctg gatgttcaag gaatacttcg gattaagcat gaaagaaaca 3885241 ttcgccacat ggacattgct ggaaaccatt atttccgttg ctggactggg attcatttta 3885301 ttgttaagtt tagttgtatg aaattaagaa ggagctgtaa cacatgttca attcgattgg 3885361 tgtcataggc ttaggcgtaa tgggaagcaa catcgcctta aacatggcaa ataaaggcga 3885421 aaacgtcgct gtctataatt acaccagaga tttaacggac cagcttatcc aaaagctgga 3885481 tggacaatct ctcagcccgt attacgagct tgaggacttt gttcaatcgt tagaaaaacc 3885541 aagaaaaatc tttttgatgg tcacagcggg aaaacccgta gattccgtca tccaatcatt 3885601 aaagcctttg cttgaagaag gcgacgtcat catggacgga ggaaactccc actatgaaga 3885661 cacagaaaga agatatgacg agctgaagga aaaagggatc ggctacctgg gagtcggcat 3885721 ttccggcggt gaagtcggtg cgttaacagg gccttccatc atgccgggcg gagatcgcga 3885781 cgtctatgag aaagccgctc ctatcctgac gaaaatcgca gcccaagtcg gagatgaccc 3885841 ttgctgtgtc tatatcggac caaaaggggc agggcacttt acaaaaatgg tgcacaacgg 3885901 cattgaatat gccgacatgc agctgattgc agaagcttat acgtttctaa gagaaacgct 3885961 tcgtctgccg ctagatgaaa ttgcatctat ttttgaaaca tggaatcaag gtgagctgaa 3886021 aagctattta atagagatta cagctgagat tttacgcaaa aaagacgaaa aaacaggaca 3886081 gcctctgatc gatgtcatcc ttgataaaac cggccaaaaa ggcaccggaa aatggacgag 3886141 catgcaggcg attgataacg gcatcccgtc cacgatcatc acagagtcct tgttcgcccg 3886201 ctacttgtca tctttaaaag aagaacggat ggcagctcaa gatgtattag caggcccgga 3886261 agccgaagaa aaacacttgg ataaagacac ttggattgaa tacgtcagac aggctcttta 3886321 catggggaaa gtatgcgcct atgcacaagg ctttgcccaa tataagatgt catctgagct 3886381 ttacggctgg aatctgccgc tcaaagacat cgccttgatt ttccgaggcg gctgcatcat 3886441 ccgcgctgat ttcctaaacg tgatcagcga agcattcagt gagcagccaa atctggctaa 3886501 cctgctgatc gcgccttatt tcacagataa gctccatgcc tatcaaacag gcctgcgaaa 3886561 agtcgtttgc gagggtatca gcaccggaat ctctttccca tgcttaacta ccgcgctctc 3886621 ttattacgac ggctaccgca cagggcgttc caatgcgaac ctcttgcagg cacagcgcga 3886681 ttactttggc gctcacacgt acgaacggac tgatatggac ggcgtcttcc atacgaattg 3886741 gtctgaataa cctgtattaa aaacacggtc agtttcaact gaaccgtgtt tttttcttct 3886801 atcccaaaca acagaagaca taagttatgt tttaaatatc ataaacagtg atacaataat 3886861 agctagaaac aatccccaag atcatcatgt gacagcagat tgctgttccg ttctattctg 3886921 cttttggcca ttgtcctttg cccttgacca tggtgtcata aaatgttcaa atgccaaaac 3886981 ggcctggcat tctgatttac aaaagtccct gaaaacctta tctaattgag aatcagcctc 3887041 tcatttatta taaaagaaat gcctaaatcc tacctgtcac acctttatta agatgaaaaa 3887101 aagtaggtta tggcttgaca aaaaatatat attaattaat aattcatata taattagaat 3887161 tattattgaa agcgattatg ctttctaata catttttagg aggaatatac attatgtctt 3887221 taatcggtaa agaagtactt ccattcgaag caaaagcatt caaaaacggt gaattcatcg 3887281 atgtaacaaa cgaagatttg aaaggccaat ggagcgtatt ctgcttctac ccagcagatt 3887341 tctctttcgt atgcccaact gagcttgaag atcttcaaga acaatatgct gcacttaaag 3887401 aattaggtgt tgaagtatac tctgtttcta cagatactca cttcgtacac aaaggctggc 3887461 atgacagctc tgaaaaaatc agcaaaatca cttacgcaat gatcggtgac ccatctcaaa 3887521 cgatctctcg caacttcgat gttcttgacg aagaaactgg ccttgctgac cgcggaacat 3887581 tcatcatcga tccagacggc gttatccaaa ctgttgaaat caatgcaggc ggtatcggcc 3887641 gtgacgcaag caaccttgta aacaaagtaa aagcagctca atacgttcgt caaaacccag 3887701 gtgaagtttg cccggctaaa tgggaagaag gcggcgaaac tcttacacct agccttgatc 3887761 tagtaggtaa aatctaagga gtgcattcaa ttggtacttg atgcaaatat caaagcacaa 3887821 ttaaatcaat atatgcagct aattgagaat gacattgttc tcaaagttag cgcaggcgaa 3887881 gatgacactt ctaaggacat gctggctctc gttgatgagc tggcttccat gtcatcgaaa 3887941 atttcagttg aaaaagctga attaaacaga acgccgagct tcagtgtcaa tcgtgtcgga 3888001 gaagacactg gcgtgacttt cgccggtatc cctctgggcc acgaattcac atcattagtg 3888061 ttggcgttgc tccaagtgag cggcagaccg cctaaggtag accaaaaagt cattgatcag 3888121 gtgaagaaga tcagtggtga ataccacttc gaatcttata tcagcctgac atgccacaac 3888181 tgtcctgatg ttgtacaagc tttaaacatg atgagcgtgc tgaacccgaa cattacgcac 3888241 acgatgattg acggtgcagc atacaaagca gaagttgaaa gcaaaaacat catggcagtg 3888301 ccgaccgttt acctgaatgg cgaatccttc ggaagcggcc gtatgacgct tgaagaaatt 3888361 cttgcgaaaa tgggcagcgg cacagatgca tctgagtttg ctgacaaaga gccgtttgac 3888421 gttcttgtgg tcggaggcgg acctgctggt gcaagtgcag cgatctacac tgcacgtaaa 3888481 ggcatccgaa ctggtgttgt cgctgagcgc ttcggcggac aggttctcga caccatgagc 3888541 atcgaaaact tcatcagcgt caaagcgacg gaaggaccga agctagcggc aagtcttgaa 3888601 gagcatgtga aggaatatga tattgatgtc atgaaccttc agcgtgcgaa acgccttgag 3888661 aagaaagatc tgttcgaact tgaactcgaa aacggcgctg tcctgaaaag taaaacagtg 3888721 atcctttcaa caggtgcacg ctggcgcaat gtcaacgtcc ccggtgaaca agagttcaaa 3888781 aacaaaggtg tcgcatactg cccgcactgt gatgggccat tgtttgaagg caaagacgtt 3888841 gcggtaatcg gcggcggaaa ctctggtatc gaagcagcga ttgatcttgc aggtattgtc 3888901 aatcacgtta ctgtactaga attcgcgccg gaactgaaag cagacgaagt cctgcaaaaa 3888961 cgtctctaca gcctgcctaa cgttactgtc gtgaaaaacg cacaaacaaa agaaatcaca 3889021 ggtgatcaga gtgttaacgg catcacatat gtagaccgcg aaacaggcga agaaaaacac 3889081 gttgaacttc aaggtgtatt cgtccaaatc ggtctcgtgc caaacacaga atggttagaa 3889141 ggaacggttg aacgcaaccg catgggcgaa attattgtcg acaaacacgg cgcaacaagc 3889201 gtaccaggct tatttgctgc cggcgactgc acagacagtg cgtacaacca aattattatt 3889261 tctatgggat caggtgcaac tgccgccctc ggcgcgtttg attacctaat ccgtaactaa 3889321 tataagaaat ccgctatatt gccagattgg caggatagcg gatttttctt tttctacaga 3889381 aaaaaaccga accaggcact acggtaaaag tgctcgattc gagcgcttct tatagttcct 3889441 caccattcgt ttgaatgaca tttttatacc actcaaagga gtctttctta tatcgtttca 3889501 tggatccgtt tccttcattg tcacgatcaa catagatcat gccgtagcgt tttttcattt 3889561 cgccagttgt gaaggagaca atatcaataa tgccccacgg cgtgtagcca attaaatcaa 3889621 caccatcgta cgtgaccgct tttttcaatg cttcaatatg cgattttaaa tattgaatgc 3889681 gttccggatc atgaaccttg ccgtcctcct ccagcgtatc cactgcgcca aagccatttt 3889741 caacgatgaa taacgggatt tggtatcggt cataaaaacg atttaacgta tatctcaacc 3889801 cggttggatc aatcgcccat ccccagtcac tcgaagtgat gtacggattt tcgacaccat 3889861 tcggcaagcc gccatttaca atatcgccag tgttatcatt tttcacatcg cttttcacag 3889921 ttgttgacat gtaatagctg aagcctaagt aatcgacggt tccgtttctt aaaatctcat 3889981 catcgccgtc ttcgaatgtg atgttgtagc cttcgcgttc aaattccttc aacgcgtagc 3890041 ttggataata accgcgaacc tgcacatcag ggaagaaata gcgctgcctc atttcttctt 3890101 cagccagcat cacatcttca ggattggagg agaaaggata aatcggcacg tgtgatacca 3890161 tggccccaat ctggaactct ggattgatgt cttttccttt tgccactgct aaggcgctcg 3890221 ccactaattc atggtgcgcc gtttgataca tgacttcctt ggcgttttcg ttttcgccaa 3890281 ccacaacacc tgaattcgtc cataggaaca gcggattgtt cacatccatt tggttgttaa 3890341 tctcgttaaa tgtcatccag tacttcactt tatctttgta acgggtaaag caagcctctg 3890401 cgaagttgac gaagaagtcc acgactttcc ggtttctgaa gccgccatat tctcttgcca 3890461 ggtgcagcgg catttcaaag tgagacaggg taatgaccgg ctcgatccca tgcttcagca 3890521 attcatcaaa cacatcatca taaaactgca aaccagcttc gttcggttca gcctcatcgc 3890581 ctttcggaaa aatccggctc cagccgatgg acgtccgcag acattttaat cccatttccg 3890641 caaacaaagc gatatcttcc ttgtatctgt gatagaaatc aatggcttca tggtttggat 3890701 aaaattcgtt ttcttcaatc gtgtcagtga tttttctcgg cacgccgtgc gcacccgctg 3890761 tcatcacatc gacgacactc ggccctttac cgccttgatt ccatccgcct tcaaattggt 3890821 gggcagctaa agcaccgccc cataaaaaat cctttggcat gtttcccatg tttaattcct 3890881 cctcagctta cgactgtaaa tattttttga tgtaatgcac tttcctcaat gtcttcaatg 3890941 aaagctttat caaactcaac aagcacttcg ccttttttga cggtatcgcc ttcttttacc 3891001 ttcaaggaaa aaggcgtgcc gtcaaatgtc accgtatcca gcccgatgtg cgcaagcaat 3891061 tcgacgccgg acgctgaacg caggccaatc gcatgctttg taggcgtaac catgacaacc 3891121 gtaatgacgc cgggatggta gcatcgattt cacgatatcc ttcgctttag gggtagaccg 3891181 cttcagcacc aatcgaagtc tggtagcgca gcgagaagcc ccaatcacat tctcttcccc 3891241 gcctacggcc tctaaaatgt cttttgctag tctcgtataa tctctcactt tccccgacat 3891301 ttcacccacc ccttcgtttt ggttacgctt tcattataat tgtaacggta taatttatca 3891361 attccgaaac aaaatattta cgcactaact atcattgtaa gcggtttatg ctataatttt 3891421 gacaagtgaa actaaacgaa taaatgagga atgcgtatgt taaaatacca gcaaatcgca 3891481 acggaaattg aaacatatat agaagaacac cagcttcagc agggagacaa actgccagtc 3891541 ctagaaaccc tcatggccca gtttgaagtc agcaaaagca ccatcacaaa gtccctcgag 3891601 ctattagagc aaaaaggcgc gatctttcag gtcagaggaa gcggcatttt cgtcagaaaa 3891661 cataaacgaa aaggctatat cagccttctg tcgaatcagg gatttaaaaa agatctcgag 3891721 gatttcaacg tcacctcaaa agtcatcgaa ctggacgtga gaaagccaac accggaagcg 3891781 gcggaaaacc tgaacatcgg aatggacgag gacatctact atgtcaaaag ggtccgctac 3891841 atcaacggcc agaccctttg ctacgaagaa tcctattaca ccaaatccat cgtgacgtat 3891901 ttaaacaacg aaatcgtctc ccactccatc ttccattaca tccgggaagg actggggttg 3891961 aagattggtt tttctgattt gtttctgcac gtgggccagc ttaatgagga agaagcggaa 3892021 tatttgggat tagaggctgg actgccgaag ctgtatatag aaagtatttt tcacctgaca 3892081 aatgggcagc cgtttgatta ctcgaagatt tcgtataatt atgagcagtc gcagtttgtg 3892141 gtacaggcta atagtttttt attatagggc tcttcactac ggtaggtggt cgacatgtac 3892201 aaaattatca ttcctgccat actagccatc tttgcgctct ggatactctt acagatttca 3892261 ctagagatga gcatcgttaa gaatccaatg aactacttta tcgtattcat tatctttttc 3892321 ctctttgtaa agatggtgaa agaaaaacaa taatagtttg ggcgatgcaa acagaaaaac 3892381 atccttccct taacaaactc agccagtcac atgcattaat cttgatgtta atgatatata 3892441 ggtgcacata aaaagctact tcattgtgaa gtagctccct ttattaaagg cccattttga 3892501 tccatctagt tttagaaaag cgaaggacaa tcgcatttat gataataatt gaaactaaat 3892561 acaaaataat aaataaaaca tcattactcc caagtgtcat gttatcagat tgcagcactc 3892621 tttctattcg ggggtacata gtgttacctg cctcaaaagg agcaatgaaa ccaaacgttt 3892681 tattgcttat agctactaag ataacagaag tcatccaata aacgatactg acacctatac 3892741 taattaatat attaggacat aacacgctta tagttccgat aattagaata tactgcagta 3892801 taactgcaga aaataaaaaa agtaataatg caaaatgcga aaaatcatgg tacatcaacg 3892861 atatgattag caggcctagc gttataaatg caaaacattc taaaaataaa acagctatct 3892921 ttttataaaa gaaagtatag atgttctctc caattaactt gtaaaagaga atatttttgt 3892981 ttgaatactc tctattaata aagaaagcta taacaaatga aaataacatc aaaccaaact 3893041 gggtcgcaac agtataggag ctaaagaaaa acatttcagg tgtaacatta ctgactttat 3893101 cgattccaac aagtaaaaaa taacccagca aaaataaaaa tacaaacatt gctcctaaaa 3893161 taatgataac tttgttgcta atactctttt taaactctaa tttcatctca agcccccact 3893221 gttttattac tcatttatat acacttcaat taatttatcc actgaatgat attgttgaat 3893281 ttcttggtga ttaaatatat aataatcccc ttctatcgcc tttaaatcag acaaatcatg 3893341 tgtaatgttg atgataatct tctcggggtt ctcctgaata tacttgttta agaagccatg 3893401 aatctctata accgtttttt tgtctaatga attcgttatt tcatctaaaa caataatatt 3893461 tttatcctct aataagaaac tgagcaattt taatttttgc ttttgtccat cactcaaatt 3893521 tttgatcaga acttttccat caatattatc cagattaagt aaatatgcga ttttatctat 3893581 catttttgca tcaaattttt tactcaaaaa gtgtaataaa aagtccttag aaacatcatt 3893641 aggtatattc gacgagctgg atattaaaga aacattttga cgaatatctc tgccgattct 3893701 tttgctatta ttcaacaaaa agtctttagc aagctgtgat ttaccgactc cattttttcc 3893761 gacaacgtga ttaattttcc cgctcgaaaa atgcaagtcg gtgtcctgaa gtaacgtttt 3893821 gcctttcact tttaaagtgt aattcgctat attcatatac atactcctag gaaatatttg 3893881 cataataata aaatgttctg ccttgtgatt tgttactaat gtctaagctt ttgaggtacc 3893941 tctttcgttt ccgatccgga agcgaaagaa atgtttttag atggctaatt tggagatctt 3894001 ttactctagt ttacaatata taatatccaa tgtacaactg aattcactgc aaggccaatc 3894061 cctataattt gaatcgtaag aactaaccaa tgatttgtct taaaacggct atattcatct 3894121 aagctcagaa aagctaaaag aattttgtaa ccatcagaat tcaatattgg gattaagttc 3894181 cacaataaag tagacgagaa aagcataaat gccatagtta atgcttcact ggaaaatgta 3894241 aattgattta ttaattctaa tgtatttatt aaaagataat tgataaacaa gccaaataaa 3894301 tgaacgatta tcttttcatt tcttgatagc atgtaggttt cattcaattg gacataaaaa 3894361 gcaggaaata cataaaaatt cagtttgaat cccactttat caaagttttt cccgaaaaat 3894421 tttaaggaat aaatatgtcc cagttcatga agcactatat tcattataaa ataaataact 3894481 ataattatcc acattttcca gccgtaaaat actgaggaca atccattttg caattttatt 3894541 aaatgaatat aatttaatat gaacatgaga gccgtaaagg ataagaacag ataaaaaaac 3894601 tttggtgata ctttctcttt atacatttta aaacgtaata attgtttatc tgacagagaa 3894661 tttaaactat ttttatagta ttctccgctt tttttgtctt ttataaatac gttgttttgc 3894721 acaagcactt catatttttc atcttcatac tttaaaattt tcattatagt atttttccat 3894781 ataaggatag aagtagttta ttttttctgc agagttgaat aaggaaccac aaactccaca 3894841 aatagaggaa aattcataag gaatgtcaaa ttcctctatt ttgttatttt cttttaaaat 3894901 attcaaaaac catttgaatc cttcttttct aagaataaat aatagcaaat tggaatttaa 3894961 cttttccacg gttctttcga aactttggtt atattcttcc cttagggtta ttttcgtttc 3895021 aaaaatagca ggggaacaac atggataaat ttctccatca tgatgatata caatgtcata 3895081 tccgggacaa tgtaaggaat cttcatcttc aagactgtaa aatttatgta tgttttcttg 3895141 cttaattcta gttttagcag cgccaactga tatcattgga aattttgtta tctttacacc 3895201 taagattgaa tcccccaatt cctctaaaat gtggttggac attttgtctt tggtaactgc 3895261 catattaaga gaaatatcga tatcagggta tttcctgcta tgttctaata tgtttttaat 3895321 actggaagac ttgacaaatg gagcatggta ctcatcataa cttatagtca gtgctatcac 3895381 atttaaagaa ttcatatcat gaaagtactc ctggaccttt ttcttgctca aaccccaaaa 3895441 tccattagag atcaacgtta tttgtttttc atatggttta atgatttcca ttagttcttt 3895501 taaaaattta taatctaaaa aaacttcccc acctgtaaaa gaaatcactt gaatggtttt 3895561 gttttttgca aattcagtta ctaactctct tatgtattct ttttccatcc tggttgttga 3895621 agttggtgaa ctagaaaaac aacaatggtc acaggatgca ttacaccttg aatctaaatt 3895681 gattgatact gttttattat acatgaaata tcccccaaca aatggtaaag gagagttaga 3895741 ctctcctttg tacccctcta attaatgacc acttccaaga atccagcgat tttcttttga 3895801 ttttacaaaa taccaaagat cattcacttt tgctaacttt tgtgattcat ctaatagacc 3895861 cttaaattct aagtttttca cagtctcatt gttagtgatt tcctttttca tattatccct 3895921 cctccttttc taatataaac caattattct atatcattca atacatgtca atatattgta 3895981 cctaaaaaat ctgaaaaatg tcactattct tggtatataa agcctatagt cctctagccc 3896041 ctctaagcta taccgaatga aaggccatag tttgatttaa agcttcgtaa tgaaaagtaa 3896101 aacatcaata ttgactacac tagttaaggg atatacagat tttaagtgga agaaatgagg 3896161 caaacaatct taccctaaac caacctgtac tgaaaagctg ttttaagctc ttgcttaccc 3896221 catttggcac ctctttctct cgttttaatt gtctctaaaa gcagttatgc ggtactatca 3896281 tataaaggtc caatgtttaa aaataatgtc atacttttaa attcacctta tcatgcacat 3896341 gctcataaag aggggtttat tctaaaaagg ggatggacgg ttttggaaag caagtaccta 3896401 gatctactcg cacaaaaata cgattgtgaa gaaaaagtgg taacagaaat catcaatttg 3896461 aaagcgatat tgaacctgcc aaaaggcacc gagcattttg tcagtgatct gcacggagag 3896521 tatcaggcat tccagcacgt gttgcgcaat ggttcaggac gagtcaaaga gaagatacgc 3896581 gacatcttca gcggtgtcat ttacgataga gaaattgatg aattagcagc attggtctat 3896641 tatccggaag acaaactgaa attaatcaaa catgactttg atgcgaaaga agcgttaaac 3896701 gagtggtata aagaaacgat tcatcgaatg attaagctcg tttcatattg ctcctctaag 3896761 tatacccgct ccaaattacg caaagcactg cctgcccaat ttgcttatat tacggaggag 3896821 ctgttataca aaacagaaca agctggcaac aaggagcaat attactccga aatcattgat 3896881 cagatcattg aacttggcca agccgataag ctgatcaccg gccttgctta cagcgttcag 3896941 cgattggtgg tcgaccatct gcatgtggtc ggcgatattt atgaccgcgg cccgcagccg 3897001 gatagaatta tggaagaact gatcaactat cattctgtcg atattcagtg gggaaatcac 3897061 gatgtccttt ggatcggcgc ctattccggt tccaaagtgt gcctggccaa tattatccgc 3897121 atctgtgccc gctacgacaa cctggatatt attgaggacg tgtacggcat caacctgaga 3897181 ccgctgctga acctggccga aaaatattat gatgataatc cagcgttccg tccaaaagca 3897241 gacgaaaaca ggccagagga tgagattaag caaatcacaa aaatccatca agcgattgcc 3897301 atgatccaat tcaagcttga gagcccgatt atcaagagac ggccgaactt taatatggaa 3897361 gagcggctgt tattagagaa aatagactat gacaaaaatg aaatcacgct gaacggaaaa 3897421 acatatcaac tggaaaacac ctgctttgcg acgattaatc cggagcagcc agatcagcta 3897481 ttagaagaag aagcagaagt catagacaag ctgctattct ctgtccagca ttccgaaaag 3897541 ctgggccgcc atatgaattt tatgatgaaa aaaggcagcc tttatttaaa atataacggc 3897601 aacctgttga ttcacggctg tattccagtt gatgaaaacg gcaatatgga aacgatgatg 3897661 attgaggata aaccgtatgc gggccgtgag ctgctcgatg tatttgaacg attcttgcgg 3897721 gaagcctttg cccacccgga agaaaccgat gacctggcga cagatatggc ttggtattta 3897781 tggacaggcg aatactcctc cctcttcgga aaacgcgcca tgacgacatt tgagcgctat 3897841 ttcatcaaag agaaggaaac gcataaagag aagaaaaacc cgtattatta tttacgagaa 3897901 gacgaggcaa cctgccgaaa catcctggca gaattcggcc tcaatccaga tcacggccat 3897961 atcatcaacg gccatacacc tgtaaaagaa atcgaaggag aagacccaat caaagcaaac 3898021 ggaaaaatga tcgtcatcga cggcggcttc tccaaagcct accaatccac aacaggcatc 3898081 gccggctaca cgctgctata caactcctac ggcatgcagc tcgtcgccca taaacacttc 3898141 aattccaagg cagaagtcct aagcaccgga accgacgtct taacggtcaa acgattagtg 3898201 gacaaagagc ttgagcggaa gaaagtgaag gaaacgaatg tgggtgagga attgttgcag 3898261 gaagttgcga ttttagagag tttgcgggag tatcggtata tgaagtgagg ggtgtggggt 3898321 tcagggatgg tgatatgctg ctcccctaaa agtagataga tgaattttag aaaatctgtt 3898381 tgccttgggg agttttttca tggctggaca attatactac aaggaagaaa tactaatact 3898441 tatagaatgt aattgggtaa tgattcggag aaagaggttg cgaaataata tggtattaca 3898501 ctgaaacaat tatcaatgga gaacatgcac gatatagccg ttctatattc tccctctatt 3898561 atggcactca ttagtagaca taaccgtaaa aaaatgcact caaaaaaagt ccattctata 3898621 taactctcgc tagggtggac ctttttcaac attcaaagta ctagattttt tctagtgaaa 3898681 gaataagaaa agacataagt tctattttat cactctgtta taggttaagt tattacggtg 3898741 tttcattata tactgaattt aaacaccctt gacattatgg gaatttttaa aacaggttaa 3898801 aaggaagttc tataagaact ccctagttta atattatttg gtcaaaatct aaaaccaaaa 3898861 aatctatttt tatcttcatt gtttctatct aattttgcaa caatcatacc tttcgactct 3898921 aattcttgaa ggtcatctaa taataattca tttttattta ttgttacaaa atattgtccg 3898981 atcctattct ctaacagact tgaattgata tgttttaata atgtaccttt tacatgagga 3899041 tcaggattag aataagatcc gtcatgaatt aaaatattca aactacactt atttatacac 3899101 ctgtataaaa accaagtaag atcaaatata tttatcttca tatggagtct accatgtgaa 3899161 cgttcatccg gtatagaaca agaaattttg atccttcctg tagttgattg ttttgcgtta 3899221 cttattctat tatcatattc aaaatctaaa aatccatgtt ggttgtatgt aacatccatt 3899281 agattattaa aaagcttctt taactcacta actatagcgc tataagattg aaactcatca 3899341 taatacattg aattaactct taatatttca tgttgaagtt cattaatctt atcaaaaata 3899401 tggttttttt tatcgtagtc actaattctc aatcttactt ccgctaactc tatttctttc 3899461 cttctttgtt cttccatcac aatggaaata tcctcaatga aattgttact ctttaaaatt 3899521 ctggcacttg attccagttg ttctgttaat ccttgctttt tgatattaag tttttttaaa 3899581 tcggcttgta ttttaacaat tttatcttta aaataactcc ctctactttc taccatgaaa 3899641 ttatagaact cttggacttt attataattc tgttttactt cctctggaaa aaaacctaca 3899701 atatcttcat agaatttttc tatattttct aattctttaa tcttagttac ttttttattt 3899761 aaatcatcta tatttctttg atattgttta caaatatgtt cattttcaaa tatttcattt 3899821 tgtattttat taagttcact tttaatttct gagtacctat ttgtatcatt attatattta 3899881 ttggcagtct tagtttgata gataactcta ttgtaatcct ctatctcatt tattaattca 3899941 tcttccttaa cttttaaatc gccaatgtta atattcattg attcaatcaa ttttatttca 3900001 ctatttaatt tttcaatctt atcccgaaaa acctttatgt ttttttctgt atgagttggt 3900061 aaagtaaaaa gatagttaag taatttatat tgttttaacc ctcccctatt cggtaaaact 3900121 atatcattaa accctgtctt ttcgtctctt ataatatact cccttaacgc cgcaaaagtt 3900181 atatcctctt tctcaccctt taaaatttcc ttttcaataa attttttata tacacttata 3900241 ctaacttttt tccattcctc caaattaaaa gttaaagaag tatcatgtaa tgtataacca 3900301 tgtttaggag aattaaaaga tctagcaagg aatacttgat ttccatcaat ttccacattc 3900361 aaaacaataa aaacgttttt attgagaaga atttcatttg tcgtataaaa atttgatata 3900421 gtcttcccta gtaaaaagga gatgcattca atcatcgttg acttacctac accattagtc 3900481 tcttcatgat cttctctctt ttcaccaagt attatattta ctcctacagc attaaattta 3900541 tactctttca aaatttcttg ggaattgcaa acaaaaagat tttttataat cataacaatc 3900601 actaactctc cgttctgcta atcatatttt gattaaaaga aactttacct aatgaatata 3900661 aaaaagttaa cgataaatac agtatccgtt caatattcaa atttattata ataccttgac 3900721 tcttagcata atcaagaaaa agttgatcaa tatgtttttc cttctctaac agttcataaa 3900781 gtatctttga tgagtataaa atattttctt ccacagcatt atatttagtt aataaaaaat 3900841 gattcatttc tggcctctcc gccttttcct tttttaaagg agaattattc actagaggaa 3900901 taagatcatt tccaatttga atgtttttaa actcattttc taataaaaca taagagtatt 3900961 tgagaatatt ttcagctgtt tcaattttaa gatcaatcat tcttaacact tcttttgtta 3901021 tcattaaaaa tctcacattc ataaatgcac caacatgtta aaatcttaat gtattttttc 3901081 gttaaagcct ttgaatatgg taaaactgaa tgacattcta gataaatctc attaacaatt 3901141 tttacaaata tctcatctcc attattatat tgattatgaa actctagata tttgtctact 3901201 atcgtctcag caatcaattc ctttttatca gcacttacat acgaagtgga atccattata 3901261 tggtttatca caccaaaata ctcagaataa ctatcgaatt tccgtttaaa agtttcccca 3901321 cttttcatat cataaaattt tttatctaaa ccaatttgat tatcaaaatt actagtaaat 3901381 gttttataac tttctctata ctcatgaaaa tctataataa agctcttaaa ctcatcttca 3901441 tcaattttat catcgttatc ttctatttct ttttcaataa ggctctctaa tctattaatc 3901501 ttataattta acttcccttc ctgtagtctc cttcctcctt ggttgttttt tgaccagtat 3901561 ttatattcgg tattccaaat gtagtatgtt acttctgtct cgccattatc taaattcaca 3901621 tccaccgaaa taaattctgg agtagcatac tcatccttta taatggctcc acttactaat 3901681 tctaagaatg gattttcatt tgtatttgca gtaatattaa atgaagaatc atgtacatgt 3901741 cctgccaaat atagatcaat aaagtaatca tcaaaatgtg cctttattga ttctctttcg 3901801 gaagattcaa tacaacctaa cgtatggtgc ccaatagcta tatttaatac cttgccctta 3901861 tttttctctt tgttcatctt ccttattgct ttatataatt tcatctgtgc agttaataac 3901921 gttccttctt cacctttttt atctgataac agacatgtat ttattgataa aacattatac 3901981 ttctccgatt gatacaaaaa atgcaaatct tcttccggat atttaacacc cataaaatct 3902041 tcataaaaat cgaaaaattt cctttgacct tccactaata tatttgtagc tttttgatct 3902101 agtttatcca acatttctga ggggttagga gatttcataa tactatcaat caaaagtgtc 3902161 ctcgtcatgt ctctagatat atcgtgattt cctggcacta agtgtacgtt attcttactt 3902221 aatcccatac ttttaataat tccattaaga tattctttaa catcttcgtt atacacatca 3902281 cctttgtgtg ctatatctcc agttaataat aaaaaatcaa aatctgactc tcttcttaaa 3902341 acttctataa aatctaataa tttatctctc attacaatag tgtcataatt ttgaaactga 3902401 aaatgcaaat cagaaatttg taaaaaacgt accttcaata caaacatcct ctcataagta 3902461 tatttatccc ctatatattt ctagaaaact ttttattcta tatcatcttt actctttaat 3902521 atattaagac tctttccaca ccatcaaata aattataacc taaacataac tctttactca 3902581 ttttagtatt gtatttaagt caaacattgc attggttgct gaaatattat attcattgaa 3902641 ttattccatt aaatagcttt tagttgaact ttagtctttc tgtaatggtg gagatgctct 3902701 tacttatgat aaggctcccc acgattaatc cgaaaagccc gataaatctg ctccactaaa 3902761 ataagccgca tcaactgatg aggaaatgtc atcttcgaga acgatagctt ctcgtccgct 3902821 cgcttcatca ccgtgtcact caatccgagt gatccgccga tgacgaaggt gactttgctt 3902881 tttccataag tagccagctt atctattgta tcggctagtt cttcggatgt tttcattttt 3902941 ccttcgatgg cgagggcgat gacgtgggcg tcggggctga ttttggatag gatgcggtcg 3903001 ccttctttgt cttttatgat tttcatgtcc tggtcgctta ggttttccgg cgctttttcg 3903061 tccgggagtt cgatgatgtc gatttttgcg taggccgaaa gtcgtttggt gtattcttca 3903121 atgccttgct tgaggtattt ttcttttagt tttccgattg tcacaatatt gatattcaca 3903181 ggtcatcccc actttaaaaa caagttattc atatatgttg tccacaattg tggatatctt 3903241 ttctgtattt tgtgtaagat cattcgttcc ccactatata tactgcgggg tctccacata 3903301 attcacaggc tgtggataaa ctgttagtat gttcgatttt tctgatttcg ggcggcagct 3903361 cgtggtcgtc tatgtacata tccagcaccg tttcgatgtg ttcttcacaa gaataatacg 3903421 cttgtttcat gttcaaatcc tccgatgttt tcttccattt ttacaaatgt tctcttctca 3903481 atataaccta tttattcaca tgttagtagt gcttcgggct gagttttatc cacaattcga 3903541 caaacaagct gttgatgact ctatttcgct cgtgtgttag tttggatgta accgatgtgt 3903601 ggggaggtct gcatttgcgc tttagatggg tttggctttt tgtgattatg ttgctgcttg 3903661 ctgagtgtca gccatcttat tgggtgttgg agaaggatcg aatcggtgaa ggcagtccag 3903721 acttagaaat atacgctaat tatctccaaa tgcatgatga cgtgaaagga tatcaagtct 3903781 tcaccatatc agaaggcaaa aaaatggtcg tcgtgtctct cggaagcagc gagaaagata 3903841 agaagcttga agtgtcggac gtcaaattct catctaaaga aacgattgta actgtggagc 3903901 gaaaacctgc tcctacggca aatgagaaaa acccttttat tttgattgga ctggacaaaa 3903961 ttgaagggga tttaattgtt caagacgaaa caggagatcg ctttgaagaa acggattacc 3904021 agcaataaag ccggcgttct gagaacgtcc ggctttttct tttacttcaa tgtcccatgc 3904081 gggtcgatga cgaatttttt ggctgcgcct ttgtcgaagt cgctgtagcc ttttggcgcg 3904141 tcgtccagag aaataacggt ggcattgacg gcttttgcga tctgcgctct gccgctcagg 3904201 atcgctttca tcaaattgcg gttgtatgtc atggcgggcg tttgtccggt gacgaaggtg 3904261 tgggctttgg cccagccgag tccgaagcgg atttttaatg agcctgtttt ggcgtccgca 3904321 tcctttgcac cgggatcttc ggtcacgtat aagcctggaa tgccaaggct gcctccgacc 3904381 tgggtgacgt ccatgattga gttcagcacg gcggctggcg cttctccttg attgccgtgc 3904441 ccagatgctt caaagccgac acagtccact gcagcatcaa cggttggttc acctagtatt 3904501 tgttcaattt gctcgccgag gcggtcgtgt ttttgcacgt tgaccgtttc acagccgaag 3904561 cttctggcct gtgccagcct gtcttcgttc agatcgccga caatcacggt agaggcgcct 3904621 aggagctgag cggagtgtgc agctgccaag ccgacaggac ccgctccagc gatataaacg 3904681 gttgaacctg tttgcacgcc cgctgtataa gctccatgga agccggtcgg aaaaatgtcg 3904741 gacagcatgg tcaaatcgag aatcttttct agcgcctgtt ctttatcagg gaataccaaa 3904801 agctgaaaat cagcgtatgg caccatgaca tattcagact ggccgccgac ccagccgccc 3904861 atatcgacgt agccgtaagc cgatcccggc cggtccggat tgacattcag gcacacatgc 3904921 gttttctgcg ttttgcacat cacacagcgt ccgcaggcaa tattgaaagg aacggatacg 3904981 atatctcctt ttttgataaa ttcaacatca cgccccgttt caatgacttc tcccgtaatt 3905041 tcatgcccga gcaccaagcc ttctggcgcc gttgtgcggc ctctgaccat atgctggtcg 3905101 cttccgcaaa tgttggttgt aatgactttg agaataaccc catgctcaca ttttcgattc 3905161 acattcgcct tcgggacgcc gggcccgtcc ctcaagatta actccggata accgatatcc 3905221 tccaccgcta cagtcccttt gcctttgtac acaaccgctt tgtttcctgt caacgccatt 3905281 cctcccattc atgtgtttgg actctccgtc cttgaacatg acttcggttc ggcatgactc 3905341 tttccctttt tcacgactgt tttttctgta ttcttacaac aacaaatatg ccaagaaagc 3905401 atccaataat ggttccgccg atgtctaaga agtcgacttt acatccattt aacaagaaca 3905461 cagtaatggc cgaaaccagg cagatcataa ctgccagaag aataacccga tttgtctgca 3905521 tgtaattcct cctttggatt cgtttctaaa ccatacccaa aatcctctgc aaacttcggt 3905581 tcaacaaaaa aagagacttc acaccagtct cttcataaac agagatcact caaaaaattt 3905641 cctgagaaat aatgtggcaa cactcgttac taacgcaatt gccgtataca taacaaccca 3905701 aaatatgaat gagctattcc ccgaagctaa cgtaactaac aatatcaagc tcgtgataag 3905761 aacgatgagc ggtgccaccc aaaatctttt aaataaaaaa tgacccgcta taccaaatac 3905821 acctgcgacg atcggaaaac caaaaacgat aaataaaacg gcgatggctc ccatactacc 3905881 ctccttgcct taaaacctct tcatcacctc aacatcatac agcttcaaat gactcttcgg 3905941 cgtcacgaca tcctttacct tcccaatctc tttttctttc attttctttc cggttttcag 3906001 gctgtactgt tcaatgtagg caggcttgtg atacgtgtat gtgaagaaat agaggctgct 3906061 gcctttttgg gtgatttctt tgaattcggc tttcattttg tccggggaaa gggtgaagac 3906121 gatgcttgtt tttcctgtct tggcatcgat tttgtgtacc tttccgaagc cgtcaatgaa 3906181 atacaggttc ccgtcataag ggaaaaagct gtttttaaag ctgaagggca tggagctgta 3906241 tatcgtttgt tcgtcgtttt tgtattcggc gatatcgtgc agctctactt cgccgctttt 3906301 tttgttgatc ttgaccattt gatagagatc gtgggctttt tggccgcgaa ccataacata 3906361 cacagcttgg tcgtccacgg caagttggga ttcgactgag gctccttccc ggtactgcca 3906421 ttccgttatg ctgagatagg taagcttctt ctgatctgct tgaatctgaa ggagctgata 3906481 gccttttccg tcatctgtcg ggacgagtgc gtaaatggcg ccatcatgga aaccggaggc 3906541 tcggatgtag taggggatga cgtctttttt ccactctccg tccatttggc ggtacagctc 3906601 tgagcggtat ccgtctccct ttttgtcgta gccggagttg tataaggtgt aaaagccgtc 3906661 cgtgttttgc agaaagcccg cgctgtcgcc tgtgtgctga taggttcttt tatgggagcg 3906721 caggccgttt ttgatcgtat aaatcgtgtt tttgtcctcc agcatcacgc tgtcaccgtg 3906781 aacctttgct gagcccagct caaggccctt catctgaaag gaagacagcg tcccgtcatg 3906841 gctgataaac agggcgtagc ttttcccgcc gccaaatgca tcttgatccg cagaggatga 3906901 gaaatacagc aggacttctt tgtcatccag gaaatcggga tttctgagat cctgctgact 3906961 cacggtttta tggcttttga gaggagaaat gaagacaaat agtgcgattc ctgcgagaat 3907021 cagcatggcg atggtaatca tccacttttt catagccttc tccttagtaa atggtcataa 3907081 tggttgtcgt ataagaagaa ctagtgatgt cgcgcggata cacgcctaag cctccgttgc 3907141 tgtctatatc aatccctgct ttcagcaaaa aggcagacca taggagcttt gaacagtttt 3907201 tggcgccgtc atggccggta tttctgttat tgacgaagtt aaatgagtat gggtcgccga 3907261 cttttgatac cgcccagtcg gcagcagctg ttttttgaga tgaggatacg ctgacggttt 3907321 gcacaatgga gttgtcttcc acgtctctgg cattatacgc gatctgcctg acgccgtcgc 3907381 tcgggacaga ttcaacaatt ttgtcagcgg cggagtacat gccgacatgg ccgtgattgt 3907441 agtaggctgt gtaggagttc gtgtaataga tattgccttt cgcgcttgtc gggagttttt 3907501 tcgtgccgga cgagccgccc atgatagaca tgccgctttc cttggcgagc cggtccccct 3907561 ctgctttatc agccgtgatc tccttataga actgttttag gataacgtcc tgctttacgt 3907621 gctgctgttt ggcaatctgg ctggcagatt tcatgatttc ttccggtgtc gtgcctggct 3907681 gcagtgcggc gatttcttca gcataatttg tggtctttac ggctttggcg ggagtaacaa 3907741 acaggccgcc gcacattgtg agcgctacca aaaacatcga cactcgtttc ttcaacttca 3907801 ttacatctcc tcttttcttg tgagtgtagg aaaggtaatt tcctcaccca cattatatta 3907861 ggaaaataag gaaagtaact aggttattta cagaattttt agaaatcgtt tacagaaaaa 3907921 ggcctttatc aggccctttt cgttaaagct tcttgctcat cactacgtct gtttcttgaa 3907981 atccggtttg ctcatatagc tttcgagccg tctgattatg ggcaaagaca tgaagggaca 3908041 gcttgcggat tcccatactg cgtgccgctt gatctaatgc cgccaatgct tgctttgcgt 3908101 agccctttcc ccgatacggt tcatataacc cgaaatcata aataaacgct tcctgctgcg 3908161 gatgctccgg ttcagcatgt atccagagcc agccaacgat atccttttca ttcagcttga 3908221 ggctccacaa atggtgatgg ggtgtttcga gccctctcgg aagcagatca gtaaacacct 3908281 gcttagacaa aagctgggca tcttcaggca gccatgttcc cgcttttacc ttttcttccg 3908341 cgtaatgctt tgttgtgtac gtgagataag accgaaattc ttctgtctgc ataggggtta 3908401 gcataattgt catatcatct ctccttcata tattgactag aggattttac ataaaataga 3908461 aagaggtgtt actatcagaa taagcaactg agattgataa gtcactagag aaaggagttt 3908521 cacatgaata agatcgcacc cgcagaaatc gctagcatgc tcaacgattg gtaccttgcc 3908581 atcaagaaac atgaagttga agaatcctcc cgtttatttg aagaagtgaa gcctttattg 3908641 gatgacatgg aagaggatca ggaggtgctt gcctacttct ccttattgga actgcgccac 3908701 aaggttttgc ttcacgaggc gagaggacag ggctttcagc atgaggagcc ttctcatatg 3908761 aatgctacgt ctgacatgct gaaatattac ttttttctgt ttgaaggcat gtatgaggcc 3908821 tataaaaata attatgacat tgccattggg ctgtataaag atgcagagca gtatctcgac 3908881 aacattcccg atccgattga aaaagccgaa tttcacctga aggtcggtaa gctctattat 3908941 aagctgggac aaaatattgt gtccctcaat catacacggc aagcagtcaa aacattcaga 3909001 gaagagacag attataaaaa gaagctggct tcagccctga ttaccatgtc aggcaatttt 3909061 acagagatga gccagtttga agaagctgag gcttatttgg acgaagcaat tcggatcacg 3909121 agtgaattag aggatcattt ttttgaagcc cagcttttgc ataacttcgg ccttctacat 3909181 gcgcaaagcg gcaaatcaga agaagcggtt tcgaaattag aggaggctct acagaacgat 3909241 gagtatgccc gctccgccta ttattatcat tctgcctact tgctgatacg agagctgttt 3909301 aagatcaaaa agaaagaaca ggccttatct tattaccaag acgtgaagga aaaattgact 3909361 gctgagccga atagaatatg tgaggcaaaa atagacattt tatatgccat ttatgcagaa 3909421 gggggtcatg cggaaacgtt tcacttatgc aaacaacata tggatgactt gttgtccgag 3909481 aaagagtatg acagtgtaag agaactttcc attttggctg gcgaacggta tagggaactt 3909541 gagctttaca aagaagctgc ccactttttt tatgaagcat tacagattga agaactgatt 3909601 aaacgaacgg aggttatata aatgaaaaga tttctgattg gcgcaggcgt cgcagcggtg 3909661 attttatcag gttggtttat tgcggaccat caaacccact cacaggaaat gaaagtcgct 3909721 gagaaaatga ttggataaat gaaaaacccc cgcgggatgc gggggttcaa tttaacgaaa 3909781 gaatcctaaa acggtttgta gttttaggat tctttcatct tttcagcgtg attgaaaacc 3909841 cttgaagtct aggaagaacg agcattggag cgcagcgaat gtttggaatt cgtgagcacc 3909901 gaagcgcagg cctgacaacg aatgcgaggg tttgtcgaca cgctgaaacc cccgcgggtg 3909961 cgggggtttt cttattacag cagcttcttc cctaacaggg attctacgag ctctactgct 3910021 gttttgcccg ttttgttttt gtgatcaagg atcgggttaa cctcaacgaa ttcggctgag 3910081 gtaatgatgc ctgcgtcata cagcatttcc atagccaaat ggctctcccg gtagctgatg 3910141 ccgccgacga caggggttcc gacacccggt gcgtcgttcg gatcaagtcc gtccagatca 3910201 aggctcagat ggacgccatc acatgctgat aaataatcaa gggtttcttc aatgaccttt 3910261 gtcatgccaa gacgatcgat ttcgtgcatt gtgtacacct tcatgccgct ttccttaatg 3910321 tacttgcgct ccccttcatc aagtgaccgg gcgccaatga tgacgacgtt ttccggtttg 3910381 attttaggcg cgtagccttc aaggttaacc agtgactcgt ggccaatgcc taggctgacc 3910441 gcgagcggca tgccgtgaat attgcccgat ggtgaagttt caagtgtatt caaatcgccg 3910501 tgcgcgtcat accagatgac gccgagatta tcgtaatgct tcgctgtgcc tgcaagcgtg 3910561 ccgatcgcaa tactgtggtc accgcccagg acaagcggga attttttctc ttcaatgact 3910621 ttgttgacct tttgcgcgag tttttcattt cccgccaaaa cggaattcag gtttttcagt 3910681 tcctcgtcat ttttgatttt ttcgcgattg atcggaatgt caccgagatc ttcaaccgta 3910741 taccccatgt ctgacagcct ctcgatcaga tgagcgtacc ggatggcact cgggcccata 3910801 tccactccgc gtcgtgcttg tcctaaatcc attggcattc caataaccga aatcgtttta 3910861 tccatctgtg attccacctc aacatttaag ataatgtcct atgcgggtta taacaaagat 3910921 gacttgcgga caacgttttt aaagctctag ctgacgattt gcctgctggc gttttttaat 3910981 gacgacatga taaatgatgt agcaaatgat cataaacggt acgccgcaat acagcgcgat 3911041 acgctgctcc ggatcaaatg caagactgat gagcacgacc gtatttaacg ttaggccgat 3911101 cagcggaagc accgggtaca gcggtgtttt aaatttcaaa tcttctatct tcccgccctc 3911161 acggatatat ttgcgtctga acatgatttg ggaaagcgag atcgtaatcc agccgacctg 3911221 cgcgctcatg cccgccaaag ataacagtac catatatacg gtttcagcct gcgcaaactt 3911281 tgtcagaagt gataggcagg ccacagccat cgttacgatt aacgagtaca tcggtacacc 3911341 gcgctgattt gttttgccaa gcgctttgaa ggcttgtcct tcattcgcca tcgcgtacag 3911401 aatacgtgtt gatgcgtata aacctgagtt cgcaacagat aacagtgcga ttaaaataac 3911461 aaagttcatg atatcagctg catatgggat tccgatttgc tcaaatacgg caacaaatgg 3911521 actttccacg acacccgcct gtttccacgg aatcatgccg gcaatgacaa tgattgaaag 3911581 cacaaagaac acaagcgttc tccatactgt ctgtttgatg gaccgcggaa tcgttttttc 3911641 agggtcttca ctttctccgg ctgcaacccc gatcagctca gtcccctgaa acgcaaagtt 3911701 cacagtaatc atcgtaatca gcattgcctt tatgccgttc ggaaataacc cgtcttcata 3911761 aaaatgtgtc aaaaacggcg cctgctctcc gcccttcaga tcaatcaggc caaacatggc 3911821 agctccgccg agaataataa ataaaaggat aatcaaaatt ttaatgcctg agaaccagaa 3911881 ttcagattcc gcaaaggctt ttgtggtgat cgcatttaaa ataaacatca gtgccgcaaa 3911941 gaccagacac cagatccaca cgtctatatg cggaaaccag cgttgcatca gctgccccgc 3912001 tgataaaaat tcaatggcgc atgtaaccgc ccagccgagc cagtacagcc agccgaacgc 3912061 aaacccgaag gccgggctga taaatttcgt ggcataggtc tggaaggacc ccgacacagg 3912121 aaaggcgact gccagctctc ctaagcagag catggtcaaa aacatgataa agccgcccac 3912181 taaataggac agaaccgcgc cgagcggtcc cgcttggtta atggtaaacc cggttccaag 3912241 gaagaaaccg gttccgatca ctccgcccaa tgaaatcatg aacaaatggc gtgatttcat 3912301 tgtccgctgg agctgatttc cgttatcttg gtttgtattc acattctgca ccccttcagc 3912361 aacttgtatt ggatctaagc tggaacatct gcatggtgct atcccagttt gctgtccaaa 3912421 gagtctctat ctatttaata taaaattcac ttcttctcat aaagatacat tatactaaaa 3912481 tactgtagct gagcaaatag ggagtgctga tttttctgtt gtaaatttat acaaacgaag 3912541 tgaatatccc gccatggtgc ggatttatgc gtttcgcagc acgtgcttaa ttttctctat 3912601 cgcccaatcc aagtcctctt tggaaatgat taatggcggt gcaaaacgaa tgactgtatc 3912661 atgcgtttcc ttgcataaaa gtccctcttc cttcaaacgc tcacaatacg gacgtgccgc 3912721 ttcagtcaat tccacaccga taaacagccc tctgccgcgg acttctttaa tgacagggct 3912781 gtcaatactc tcaagctcgc ttttaaagta ttcaccaagt tcaagagaac gatccgccag 3912841 cttttcatcc tccagcactt ctaatgaagc gatagacact gcacatgcaa gcgggtttcc 3912901 accaaatgtt gagccgtgtg agccagggtt aaacacgcct aggatctcgc ggtccgccgc 3912961 aatgcaagag atcgggaaca caccgccgcc aagcgctttg cccaagatat acatatccgg 3913021 aacaatgccg tcccagtcac aggcaaacgt cttgcctgta cgtccgagac ccgtctgaat 3913081 ttcatccgca ataaacaaga cattctcttc cttacaaatc gccgccgctt cctgtaaaaa 3913141 tccttcaggc ggaatcacaa tgcccgcttc gccttgaatc ggttcaaaca agaatgccgc 3913201 tgtattcggc gtaatggcct gtcgaagcgc ttccacatcg ccgtaaggaa tgagtttgat 3913261 tcctggaagc atcgggccga atcctcgttt atattcctct tcagaagaaa gagataccgc 3913321 cagcatcgtg cggccgtgga agttcccgac acatgcgata atttccgctt gattgtcagc 3913381 tacgcccttc acttcatacg cccagcgtct cgccgctttc accgcggatt caaccgcttc 3913441 ggctcctgta ttcatcggca gaatcatctc tttgcctgtc agtttagctg ttttttcgta 3913501 aaacggccca agctgatcgt tatgaaacgc gcgtgacgtg agggtgattt tatcagcctg 3913561 atcctttaat gcctgaatga ttttcgggtg tctgtgcccc tggtttaccg cagagtaagc 3913621 actcagcata tccatatatt cattgccttc cgggtccttt acccaagcac ccagcgcttc 3913681 agaaataaca atcgggagcg ggtgataatt gttggctccg taatgagacg tctgatcaat 3913741 aatttctttg gatttagata aagctgtcat atttgaattc ccccttgttt tctgtttcaa 3913801 catgttatcc tgctttccct ttatataaat gcaagttctg tgccaaatca agaattcgtg 3913861 tgttttctac aattttcgag gacaaggtgc aaaaacattc tgatatttcg agcgaaaatt 3913921 tcagcaagtg caaaattctt ttgcatatcc tctccgtttt tttataaaat agaagcaata 3913981 ttaagaaaat aattgaggga ggttcataca gtggtcaaag acagcgaatt cctcacattg 3914041 gtttttcaga gtattttaga tgaaatcgat gttggcctgc acgtggtaga cgagcatgga 3914101 aacacaatcg tttataacaa taaaatgatg cagattgaag atatggagaa gcatgacgtc 3914161 ttgaataaaa acctgatgga tgtgtttatg ttttcaaagc agcaggacag cacactggta 3914221 caggctcttc aggaaggcaa gacgattaaa aacgtcaaac agagctattt caataataaa 3914281 ggccaggaaa ttacgacgat caatcataca tatcccatcg tccaagacgg caaaatcagg 3914341 ggcgccgttg aaattgccaa ggatgtgaca aagctggaac ggctgatcag ggagaatatg 3914401 aacaaaaaag gcagcacaac ctatacgttt gacagtattc tcggcaccag tccggccatt 3914461 caagacgtca tcgaaaacgc caagcgggca acccgtacgt catcatctgt ccttctagca 3914521 ggcgaaaccg gcacgggaaa agaactgttc gcgcaaagta tccataatgg aagcgatcgt 3914581 tctggcggcc cgtttatttc gcaaaactgc gcggcactgc cagacagcct tgtggaaagc 3914641 attttgtttg ggacgaaaaa aggcgcgttt accggcgctg tcgaccagcc cggcctgttt 3914701 gaacaagccc acggcggcac actgctgtta gatgaaatca actcgctgaa tctcagcctt 3914761 caggcgaagc tgctgcgcgc ccttcaagaa cggaaaatca ggcgcatcgg ttcaacaaag 3914821 gatacaccga ttgacgtacg tattattgcc acgatgaatg aagacccaat tgatgcaatt 3914881 gcaggcgaac gaatgcggaa ggacttgtat tacaggctga gtgtcgtcac actgatcatc 3914941 ccgccgcttc gggaacgaaa agaagacatt ttgcttctcg cgtcggagtt catccagaaa 3915001 aacaaccatc tgttccaaat gaatgttgaa cacatcagcg atgacgtgaa gcaatttttc 3915061 ctttcttatg actggccggg aaatattcgc gagcttgagc atatgatcga aggcgcaatg 3915121 aatttcatga cggacgagca aacgattacg gcttcccatc tgccctatca ataccgcatg 3915181 aaaatcaagc cggctgacat cccagagccg gaaacaccaa gacaccagcc agccgcggac 3915241 ttaaaagaaa aaatggaaag cttcgaaaaa tatgtgatag agaacgtgtt aagaaaacac 3915301 ggccataaca tctcgaaagc tgctcaggag cttggcatca gcagacaaag cctccaatat 3915361 cggctgaaga aattttctca ctcgtctaac gaataatccg gagcaggaag cctgatcaga 3915421 aaaacagtgc ctctgccgat ttcacttttc acttcaatcg tcccattgtg attgtcgata 3915481 atcgatttcg ttatggcaag gcctaatccc gaacctccat atttccggga gcgggatggg 3915541 tctgccttgt aaaaccggtc aaacactaaa aaacgtcact tcttatgcat tgaagaaaga 3915601 aaatggcacc tatgtgtatc acagccagca accacacggt acaaaccatt aaagtccatg 3915661 caaataacgg aagtatttgc agctaactgc catttgctgt ttcacgtgta acatccatct 3915721 tgtatttttc ttcatattcg atatatcctt tttcaactga acgggcgtga cccctgttca 3915781 gttttttttg catatcaaaa cagcctggca acgatgccag actgctttta ttaactgcct 3915841 aattggtctg cggaggacag cttgatatca acagattttt cttttccgcc gcgataaaac 3915901 ttcaccttca cccggtcacc gacttttttc tgataaagcc gttttcgcag gtcaacaata 3915961 tcatttactt tgtatccgtc aaattccgtg atgacatcca gttccttcag ccccgctttt 3916021 ccggcaggtg aaaaggcgtc tacacccatc acaaccgctc cattggtgac gttcttagga 3916081 agctttaatg tttcatccca atgatagctt gcgatgtcac ttagcgattt catctcaatg 3916141 ccaaggaacg ggcgtttgac ctttccgtat ctctctaaat cctctatcac agggatcacg 3916201 agcttagacg gaatggacag gccaatccct tcaaccgctg actcggcaat tttcattgaa 3916261 ttgatgccaa tgaccttccc atccatattt aacaaagcgc cgccgctgtt cccagggtta 3916321 atggccgcat ctgtttgcag gacttcagcg ttccagtcag gctgtccatc accgtttgaa 3916381 tctactggga tcgccctctc cgtacccgag atgacgcctt gtgtgacaga gcctgcaaac 3916441 tcaaggccta acgggttccc gatcgcaata accggctccc cagacttcac tttatctgaa 3916501 tttccgaaat cagcgactgc tttaatctta tcgcttttca cccgtaaaac ggcaaggtcc 3916561 atcagctggt cgctgccgac aagatcagct gatacacgtg agccgtcttt caagctgatt 3916621 tcaatttggg aagcgccttc gatgacatga tggttggtca cgacataagc ggaatggtca 3916681 tttttcttat agatgacgcc agagccgctc ccagcctcgc cgctctctcc ccaaatatct 3916741 gatttttgga tgttcacaac accgacaacg gcgggcgaca tattgctgac aatcttggtg 3916801 acggcattgt tgacactgac attcaccgtc ctgattgatt cccggccatt gttgttttgc 3916861 tgctgatcta aggcgcctgt atccagccct tcatttgaaa ggtacggcat gataaacgcc 3916921 attaatacgg caccgacaat cacgccaatc agactcgaaa gaaaatatcc ttttttgctt 3916981 ctctttggct gttcaggagt agtatgttct tcctcacgtt cgtaatccac catattccat 3917041 cctttccaag aacgttaata tggttatatt gtgggttaga aactcctaga atagtcatga 3917101 tttacataga aaaattatac agcgcaaagc ggagtggcct tcttcggatc ggtgtcgtat 3917161 aagtcaaatg tctcacccgt cacaaatcct ttagaagcca atgtctgctg cacagacatt 3917221 cttgccagct ccttcatgtt gttgtcctgg ctcaaatgcg ccaggtaaat acgagacgtc 3917281 tcatcgccaa tgacatccgt catcgccaag gcagcatctt catttgacac gtgcccgacg 3917341 tcacttaaaa tccgccgctt aatgctccat gggtatcttc ccatttgcag cataccgaca 3917401 tcgtgattgc tttcaaacac aaatacattc gctgaacgga taatgccttt catccggtcg 3917461 ctgacatatc ccgtatctgt cattaacgcg agctttcggc cgctataatg gaatacataa 3917521 aacatcggtt ccgccgcatc gtgggaaacg ccaaacgatt caacatcaag tccgccgaac 3917581 gacttcaccg tctccattgg aaatacaaac ttttgatcgg tgtcaatttt gccgatttga 3917641 ttctccatcg ctttccaagt cttctcattc gcatagatcg gaagcttgta ctttctggcg 3917701 acgacaccaa ggcccttaat atggtcacta tgctcatgcg tcacaaaaat gccgtctaca 3917761 tcatccagct tacgcccgat ctgcgccatc agcccatcca tggcttttcc gctcaaaccg 3917821 gcgtccacta aaaatgcgtg atcctctgtt tcgaggtaaa acgcatttcc cgtactcccg 3917881 ctcgcaagta cgctaaattg caagctcatg tttgtctcac tccattattt tcattgatct 3917941 gtatctaaaa tcgtactctc caaagcattc acagtaaaat actcttgtac tgtctttttc 3918001 tcaccgttca cttttttctc gtactcgacc gtaattctcc ataccggcgc cagcacctgc 3918061 gtacttgtca gcggatattg tgctacatag ccgaatttac agctcttcac agtgctgtat 3918121 tcttttaatt gattttgata gtacaatagc tcaaccgcat ccatttcagt aattaagctt 3918181 tctttctgga tttgcttgaa ggtctcaagc gtagtctggt cgtatgacac aacctcgttt 3918241 ttaccgttta agtgcagcac cacttgcccg atcatattag agggattgtc ggtcttttgg 3918301 taaatataat gaccttcgta cgtttggaag aaaataattt ctttcttcga tttatcaacc 3918361 ttccaaagct tatatttttc gccatcttga attttcgaag aaacaagtgc ctgagcatcg 3918421 tcctcgatat ccttctttga tagtgcgatt ggatttgcaa acttcatttt caggctcgtt 3918481 actttatgat catcactagg catgtccatc aaaggctttt gatccttcag cgcctcaatt 3918541 tcctccttgg agaaagactt ttgatttgcc gtgatccgat agccttctgt tgcttcctta 3918601 ttcaagcctt catacgtgat atgatcggcc ttcatgtcat gctcgacatc atttttaatg 3918661 acttcatatt ctttgccggt agcctgccat ttttgaaaaa actgatagcc taagaaaata 3918721 tctaaaatga ggaaggcaac gatgaagatt gattttgtct tattccactc cactgttagc 3918781 cccctccttc ctcaataaat cctttgtaat cggcacaatt tttccattta ctttcatcgc 3918841 ccaaaccggt tccagttcaa cgagaggatc atcgttggtt gatgttgata ccaattgata 3918901 agcaaggaag atctgatcaa ttttgtccgt atcataagcg gtttgtttcg aaagcagcat 3918961 cttcacttcg ctgccgccca tgagctctgt ttcacttgtt ttaatcggat tcgttccgag 3919021 actgtaattc ggccgcttat agctgagaat atcatcattc gcccattgca ccgtaatcgc 3919081 cgatgtcgcc ccgaaaggtt tggcggtgct gttaatgacc gggatctgat ccataaaaat 3919141 atagaagctc aactgctggc tgtcattgat attgaaaaat tgatagtgat ccgtccagct 3919201 tccggtatcc tcaaggtatt tttggctctt tttgattaat tcacctgttt gataggatgt 3919261 gctctgcacc aaattgcgct gctgaaattg cacctgtctc tggcttagat tcacatctaa 3919321 ccggctgatc ccatctgtca gcacatttct gttgttgtaa ttcgaatctt ctcttacaat 3919381 gctcggatca ctaaacaaag cctgcttaaa ggtatttgtt ttaatcgatt ctgtgacaaa 3919441 ttcttttttg tccatcgtaa gcggtttgtt cggcagcaag aactctttct ttgagccaat 3919501 ggagaacaaa ctgaacgccg gcatatttga ttgcctgttt ttcaagtcgt tcataatgtt 3919561 ccggtagttt gctgattcaa ccgtcacttc aagaatgagc tgcttgctgt atgacaccaa 3919621 atagattttc ttgttcgctt ttgtttcatt gaacgggatc agaatatggt caaacgaact 3919681 gtattcaaac gactgattag accatttaaa cagcgtttgg aaaatatcaa tcgggatcgt 3919741 atcgctgaat tgcaagtcaa gcttggcttc agaaccgcct attccataaa accagctttt 3919801 gaatccagcc ttgtcatact gatccgaaat atctttaatt cctttcacat cccaatgcgg 3919861 caagtcagac caaatttctt catagagggc attgtcatcc actttgtaat gagcgccgtc 3919921 atcatggata aacatgtccc ttggccttac cgtttcagac agcttttggg tggttttttc 3919981 gattttatgt ttcacacgaa cagtagactc tgttgaggat gagccttcag aaaagtttgg 3920041 ctggaacgtc catatccccc atgtaaaaac aagactgatg acgacgagta ccgtaagtaa 3920101 tatcgttttt atattttcac gcttcatccc aatcatcctc ttgttcctct ttatatggaa 3920161 gagtaaatgt aatcgtcgtg ccttttcctt ctatgctgtc cgcccaaata tctccaccgt 3920221 gcgcctgtac catttccttg gcaatcgcca atcccagacc ggtgccgcca agctttctcg 3920281 ttctcgcttt atccaccctg tagaagcggt caaagacttt ttcgacatct tttttcggaa 3920341 tgccgatccc ttcatccttc acgctgatat agagaagttc ttcctcttca ttgacatcaa 3920401 tcgagaacgt gacatgtccg ccttccggtg aatattttaa agcgttagaa ataatattat 3920461 cgagcacctg cgttatttta tcctggtcaa tctcgacata cagatctctg tccggcagat 3920521 tgcggataaa ctccacatgc tgctcttttg tcatttcaaa acggtcaata ataagtgaca 3920581 taaaccggac aatctgaatc cattcccggt taaattgata atctttactg tcaaatttcg 3920641 acagctgaag cagatcattg acaagccgga tcatacgctc tgtttcattt tgcgtcacca 3920701 ttaagaagcg cggagcaatg tctttatttt cccacgcgcc ttcagctaac gcttctaaat 3920761 agctgcgcat tgtcgtaagc ggcgtccgca gctcatgtga tacattcgca acgaattctc 3920821 tgcgttcctg atccattttc tcttgttcgg ttacatcgta aatgacagcg attaaaccat 3920881 caattttgcc gtgttccctt tgaatcacag agaaattcac gcgaagcacc gttaattcat 3920941 catcgcgctc aatttcaagc agcatagaat cctgctgttc cactaaatct tcaaaagtat 3921001 aattctcttg aagccccagc aaactcgtaa tcggcatttc taaggctgtt tcacgtgaaa 3921061 cgttcaacag ttccagcgcc gggctgttta agagaataat cgctccgttt cggtttgtgg 3921121 cgataacgcc gtctgtcata taagcaatga cagaggctag ctttctgcgt tctccttcag 3921181 tcatcgcctg ggcatcttca agctctctcg ttaagtggtt aaacgttgtg gccagctgcc 3921241 caatttcatc atgtccatac tttttaacct tcctcgagaa attccctttc gcaagctcca 3921301 tcgcctgctt tcgcatatct gaaagcgggt gggtaatggt tcttgccaga aaaataccga 3921361 gaagagccgt caaaacaagt gccaaacctg tgccggacgc cagtatcgtg ttgatcgtct 3921421 tcatttgatt aaagacatct tccatactcg cgacaacgta gatcgcgccc acaacctctt 3921481 ggttttcagt catgacgggc ttcgcggaaa taagaactct gattttgctt ttcgggtcat 3921541 aatattttct taaatacgac tgtttggtag aaaagattct tttgaaaatc agatcggtcg 3921601 tttgtttccc agccacttcc tcaccgtacg gctttgaaga accgaccact tcatagcttt 3921661 tatctacaaa gctaatttcc cgaacctcat cacttttcgt gaagtcattc aaaatacggc 3921721 tgacgtcatc ctttatgacg gtactgtcgt tatcgctctt atattcttgt tcgatataat 3921781 aagaaaggtt gtcgattcgc tgattcagcg attgttcata agagctgatc agcgacttct 3921841 ctacctgatt gacaaaatac acaccaatga tttgcatggc aatgataatc aaaagcacat 3921901 aaatcaaggt aatcttaaat tggatcgacc gaaaaaaacc aaccttattc atatgggcat 3921961 tagtcctgtt ctgggtttct caagtaataa cctacaccac ggcgtgtgac gatccaattt 3922021 ggatggctcg ggttgtcctc gattttttca cgaagccggc ggactgttac gtcaaccgtt 3922081 ctgacatcgc cgaagtaatc atagccccaa acggtttgaa gcaaatgttc acgggtcatc 3922141 acttgtccga tatgttttgc taaataatga agcaattcga actcacgatg agtcaattcg 3922201 attgtttcgt ctcgttttga tacaacgtac gcgtcaggga agatgacgag agagccgata 3922261 tgaatctcgt tagaggaagg ctcttcctcc gcaggcgctg ttgtcagctg gcggcgcagg 3922321 ttcgctttta cacgcgccaa gagctcgcgt gtgctgaatg gttttgtgac atagtcatca 3922381 gcaccgattt caagcccgat aaccttgtca atttctgaat ccttagccgt cagcataatg 3922441 attggcatat cgtatttctt tctgacttcg cggcatactt caacgccgtc tttatttggg 3922501 agcataatat ctaaaagaat taaatcaggc tgaagctctt ctaccatttc aacggcttcg 3922561 tttccgtcgt gggcacagtg cacttcatag ccttcttttc ttaagttaaa ttccaatata 3922621 tctgcaatcg gtttttcatc atctactaca aggatctttt tatccatcat tttgattttc 3922681 ctcctgccga atgacttcat ttcatctata taacattcgt ttcatcactt atggcccatg 3922741 taaagaatgg gtccttgtct attataacgg tttaaggtca aaagataaaa aaaataaagg 3922801 tttagaaaaa aaacacatgt ttcaccttta tcgccagttg tttatctatt gtcatgctgg 3922861 tcaacttttt ttaaaaaaga taactttatt gaaacctccc ctcaccggag tgcgtcttta 3922921 tcaatgacgt cttcttcttt gaaccggccg cagggccggt tctccctttt tcttctatta 3922981 taacactcct catgtttgcc tttttcctaa aagaaaaaac gcacctacga ttgcagatgc 3923041 gtttggtaag tggctcggga cggaatcgaa ccgccgacac acggattttc agtccgttgc 3923101 tctaccaact gagctaccga gccaaatgtt ttatttttct ctactaagta aagtaaaatg 3923161 gcggtccgga cgggactcga acccgcgacc tcctgcgtga caggcaggca ttctaaccaa 3923221 ctgaactacc ggaccttaca gtaattgccc ggagagctgt cgtgtcagct ctcacagaca 3923281 aataaggaat ttagcaataa cgctaaagta aatcaatgac ccgtacggga ttcgaacccg 3923341 tgttaccgcc gtgaaagggc ggtgtcttaa ccgcttgacc aacgggcctt cacgaaatgg 3923401 tgagccatga aggactcgaa ccttcgaccc tctgattaaa agtcagatgc tctaccaact 3923461 gagctaatgg ctcttaaaga tgtcggaatt tctatagagc aaacgactta aatctagttc 3923521 tcatcttgta ctctattgaa gcagtttccg taacaacgag atttataata tcacgaacaa 3923581 atagaagtgg caataacttt tttggttttt tttcatattt ttttctcaga ccaacttata 3923641 tgcggctttc aaacaaaaac aagcccctta aataggggct tgcagacata ttctatttag 3923701 ttcgcacggt acacactgcg aaggacattt gtttgtgagc ggtctggacc gacagagaaa 3923761 atagaaagcg gaatgcctgt cagctgagac acacgctcaa gataatggcg cgcattttcc 3923821 ggaagctcgc tcaagctctt cgcacctgta atatcctcag tccagcccgg catttcttca 3923881 tataccggct cacattcagc aagtgcctta agacttgctg ggaattcttc aatgatttcg 3923941 cctttgtagc ggtacgccac acagattttc aacgtttcaa ttcctgctag gacgtcaatt 3924001 gagttcagag aaagatctgt aattccgctc acacggcggg cgtggcggac aacaacgctg 3924061 tcaaaccagc cgacacggcg cgggcggcct gttgttgttc catattcgcg tccgacttca 3924121 cggatttgat cgccgatttc atctttcagc tcagtcggaa aaggaccgtc gccgacacga 3924181 gtcgtatatg cttttgatac accgacaacg tgcttgattt tggtcgggcc gacaccagaa 3924241 ccgatcgtga caccgccggc aaccgggtta gatgacgtaa caaacgggta tgttccttgg 3924301 tcgatatcga gcataacccc ttgtgcgcct tcaaataata cacggcgccc ttcatcaaga 3924361 gcatcgttta agacaacaga tgtatcgcaa acatactttt taatctgctg tccgtactca 3924421 taatattcgt ctaagatatc ctcaagttta aacccttctg tctcgtacat tttctcgaga 3924481 agacggtttt tttcttcaag attgcgctca agcttttccg caaacgcgtc acggtctaac 3924541 agatccgcga tgcgaattcc gatgcgggct gctttatcca tgtaagcagg gccgattcct 3924601 tttttcgttg tgccgatctt gttagcccct ttacgctctt cttccacttc atccaatttc 3924661 aaatgatacg gcagaatgac gtgagctctg ttgctgattc tcaggttatc tgtactcacg 3924721 ttgcgctcat gaagatacgc aagctctgtg actaatgctt tcggatctac aaccattccg 3924781 tttccgatta cacacgtttt atccttatag aaaattccag acgggattaa gtgaagctta 3924841 tatgtgattc cgtcaaactt gattgtatgc cctgcgttat ttccgccttg ataacgggcg 3924901 atcacttctg cattttctga taggaaatct gtaattttac cttttccttc atcgccccat 3924961 tgcgtaccta ctacaactac tgaagacatg tccgtgcacc tccgttaacc tttcaaaacg 3925021 attctattca aacaaatcaa gtttatcagt gaagaaacag aaagtcaatt gtaaatccga 3925081 acattaattt attgtaaatc tatattcgtt cgcttccatt cgttttataa gcgttttctc 3925141 actgctttgt cataaaaagc ttgcgaaact ttcatccttt agcataagaa agaatcactt 3925201 gcctgatatc ccttttgaat tcataaaaac gatccgccag ccgtccgggt cctctatcgt 3925261 cacgccccca ttgctccagt acgggttctc tgattcgacc tcttgatagc ccatgtgctt 3925321 tagctttgaa gtgatcgctg ccagttcaac tgcattcggc acataaaaaa caagaaggct 3925381 gtcgggatgg ggaacggggg cagtgcttcc cccttcatac tgggtgaatt ccaaatgata 3925441 atcggcatga ggaaggccga acatgacacc gtcatacccg ttatgctgtg aaaattctcc 3925501 tattcgtttc aaacacagtc cctcttcgta aaaacgaata atctcatcaa gctggcccgt 3925561 aggacgcgca attcggattt gtgctgcttg aaaagacgaa aaacgttttc ccatattgtt 3925621 accatctcct ttttgcacca ttttattaaa acgctttcaa tttttcatcc gctgagcgaa 3925681 cgtcatttct tccatctttc gaatgaaaaa aaccccaaga gcagctcttg gggcttatgc 3925741 gccgggcgga acgcctgcgt catcaaaacg ccgttccagg ttgacgaatt tgttgtattc 3925801 ttttacgaac gcaagagaca cggttcctac cgggccgtta cgctgtttgg cgataataat 3925861 ttcgataata tttttattct cggtttcttt gtcatagtag tcatcacgat aaaggaacgc 3925921 gacaatatcc gcgtcctgct cgatacttcc tgattcccgg atatcagaca tcatcggacg 3925981 tttatcctga cgctgctcaa cacccctgga aagctgagaa agcgcgataa cagggacttg 3926041 cagctccctc gcaatcgact tcagttcacg ggaaatttca gatacttcct gctgacggtt 3926101 gtcctttgaa cgaccgcttc cctgaatcaa ttgcaggtaa tcgatcaaaa tcatgcccag 3926161 cccgctttcc tgcttcaagc ggcggcactt ggcacggatt tcactcactc gaatacccgg 3926221 tgtatcatcg atgtaaatcc cgctgttcga taggcttccc attgccatcg tcagcttgcc 3926281 ccaatcctct tcggtcaggt tacctgtacg gagattctgg gcattgatat ttccctcggc 3926341 acagagcata cgcataacga gctgctcggc acccatctca agactgaaaa tcgctacgct 3926401 ctcatcggtc ttcgtcgcca cgttttgtgc gatgttcagg gcaaaggctg ttttccctac 3926461 tgaaggacgg gcagccacaa tgatcaagtc gttgcgctgg aaacccgcag tcatccggtc 3926521 aagctccgta aaccctgttg gaattcccgt gatatcacct tttcgattgt gaagctgttc 3926581 gatattatca taggtctgga caaggacgtc cttaatattt tggaaggcac tcgtgttttt 3926641 gcgctgtgcc acttccataa tcgttttttc cgcttcactg agtaaatcct cgacctcatc 3926701 ctcacgggta tacccgtctt gagcaatcgt tgtcgcagtt ctgattaatc ggcgaagaat 3926761 cgatttttcc tcaacgattt tcgcgtaata ttctatgtta gccgctgtcg gcaccgagtt 3926821 tgcgatatct gtcaaatatg aaataccgcc tacttcttcc agcaggtctg tgttcgcaag 3926881 ctctgatgta actgtcacca gatcaaccgg ttcacctcgg tcaccgagca ccagcatcgc 3926941 attatagatt ttttggtggg acattctata gaaatcatct ggaatcaata cttctgaagc 3927001 cagtgttaaa gcagacggct gtaaaaaaat agcgcctaac acggcttgtt cggcttctat 3927061 attttgcgga ggaagccggt cattcagaag gtctgtcatg ctaagcaccg tcctctcatt 3927121 aaaaaatctc caacctccat tctaccattt ctacagaaaa aaaatagaaa aattgtctgt 3927181 ttcctgtttt tttcagttag cagattggat cgtttcggac agtaacaagg cgggaaaaat 3927241 gcaataaaac ataagggagg aatgaaagat gataaagaaa tatgcgatta cacctaatgt 3927301 tgatgcggac ggctggttta ttgaggtgga gaatgtagcg ccgacagctt tgtatacgtc 3927361 taaagacgcc gctattgaaa aggccaaaca ggtggctaag gaaaacagtc cgtctaagct 3927421 tgtaatttat gaccagttta aaaatgtgga agaagaacac tcattttaat gaatgaaagc 3927481 cttcgctgca gcgagggttt tttagcggtt atcggtttat ttcatccatt ggatgcctat 3927541 gtgcatcatc aaatctgccg ctttttgata cagatcccac tccccgatcg aagcaaattt 3927601 ccccatcagc tcctgaagct ttaacctcat tgctatatat tcttcgaaag tgacagcttt 3927661 ttcagtgtct atttggtgtt ccttcagcat ttgttttaat aaggataacg gtgcgtgcat 3927721 aagaaccctc cttacctctt ttataacggt cattttccga ttgctctatt cctttgtgac 3927781 atcttcttac atttcacatc tgattcttgt acaatggaca gaagagagga gggatctttt 3927841 gtgagacctt tgcaaatttc tgccgaaact gcacaaaagc ttgcagagtc cttgaatctg 3927901 ccgcttgaac agatcatgca tatgcctcag catattctgc ttgccaaaat ggctgaactg 3927961 caaaaagagg acaaatcata gccttcattc acatacttgc ttacctgttt cgggataata 3928021 tcatgtatat gttagaaaag aggagtaact gctttgccac atccacataa taaaaaaatc 3928081 caatcatttt ggctgatcac cggcattatc tttatcgcct ttaacttacg gcccgcgatc 3928141 acttcagtcg gtccggtcat cagctctatc cgggcagagc tgcacatgtc caatggggca 3928201 gccggttttt tgaccgcact gccgctgctt tcgtttgcag ttctttctcc gcttgcacct 3928261 aagcttggac agcgcctcgg taatgagcga actttatggc taggtctcgt gatactgctg 3928321 atcggtgttc tgactcgttc taccggctat actgccgctt tgtttttcgg aacagcactt 3928381 atcggcgtcg ggattgcgat tggtaacgta cttttgccaa gcttaatcaa acataaatac 3928441 cctgaaaagc cagggatcat gatcagcctg tatacgacat caatgaatat attcgcagct 3928501 ttagcatcgg gtgtcagcgt tcctttagcg acccagatga atggcggatg gaaacaagcc 3928561 tttctcttat ggggcgggct ggctttactt gcattgctaa tctggatacc tcagctgcgc 3928621 catcgagata cggcaaacca gacaatgaag ctgcaatcca gttccatttg ggcttccaaa 3928681 atggcatggt atgtcaccat ctttatgggc ctgcaatcgt ttttatttta cagcagcatc 3928741 gcttggtttc ctgaaattct ccgttcacac gggattgata cggcaacagc cggatggatg 3928801 gtatcactca tgcaatttgc gagtctgcct tccacttttc tgacgccagt tttagctgac 3928861 cgtgtgaaac agcagcgcgg tatcgttgcg gcgctggcct cagtttatct gatcggcctt 3928921 tgcggattat tagcgggcgg aagccataca ttgcttgcca tctggatgat cattatcggt 3928981 atcggacaag gctccagcat tagtctggcc cttactttga ttggtctccg cagtgaaaat 3929041 gcccaacagg ccgctgcgct gtcaggcatg tctcagtcat tcggctacct gctggcagca 3929101 gtcgggccaa tctttgtcgg ctatctcttt gaccagacgc attcttggac gatgccgatt 3929161 gtgcttctca ttgctgccct gatcgtaatg ggagcagccg gacagggagc cggacgagat 3929221 cgatacattt tccagtcaga aaaacaaaga aattcagcat aaagcgggga agatatctcc 3929281 gcttttttct ttgaatattt atggtttatt cataagtttt tcatatttgt tttttacaat 3929341 gagacaccat aaagaggtga aaaacgatga aaaccaaacg attcgacgca gcccttattc 3929401 ttattttgct agcagcagct tttttgaata cgtatcacat ttggcaggat gatacagcaa 3929461 accagtacta tttggcggct gtaaaaagca tgacgcaaag cttccataac tttttttatg 3929521 cgtcatttga cccttctgga tttgtgacag tagataagcc tcctgtcgtg ttatggattc 3929581 aaacgatttt cgcactgatt ttcggtgttc acacgtggag tgtcatcatt ccccaggctc 3929641 ttgccggagt tggatctgtc ttccttctct acagaatggt taagccgact tttggagttg 3929701 gagcggcccg cattgccgca cttgtcatgg cactgacccc tatcgcagta gctgtcagcc 3929761 ggacaaacaa tatcgacagc atgcttgttt ttaccttatt gctcggttca acttgtctgc 3929821 ttagggcagt aaaacaaggc aagctggttt ggctgctgac ggcatttgcc ctgattgggc 3929881 tcgcctttaa tatgaagatg atgcaagcgt ttatggtatt gcctgcattt gtgttattct 3929941 acctgattgc atctcgggtt tctctgaaga aaaaaatcgg gtccctgctt ctgtctcttg 3930001 tccttctgac aggcctttca ctctcatggg cgattgcagt ggattcagcc tcttcctcaa 3930061 gccggcctta tgtaggaagc agccagacta actcagtgct agaactggcc tttggctaca 3930121 acggcacaga gcgtctgttt gggcaaacta cgggccttgc aaagggtgat atgaatgctg 3930181 ctggcggagg gaacatgcag aatcaagaca acatgcaagc gccaaatggc aacggttcat 3930241 ctttttctca gaacggtaat caatcattcg gaaaccattc acaggcgcct cagccgccta 3930301 acggacaaac cggcgctctc aatggaggcg gaggcacacc tcccacaggt ggcaacggac 3930361 ctggaaatgg agggcctggc ggcggaggcg gaaaaagcgt gaatatgttc ggcaccggtg 3930421 atcctggacc gcttcgtctc ttccaatcag cactttccgg ccaaatcagc tggatgcttc 3930481 cattctcatt gatcggatta ctgggcgcaa tcatcagctg gtaccgtgat cgccgcggac 3930541 atgctgctaa aatgaaagaa acgctattct gggcggcttg gcttgttccc gtggctggtt 3930601 tcttcagcat cgcaggattc ttccaccagt attatttgat tatgctggca ccgccgattg 3930661 ccgccctttc tggtatcgga tggtatacga tgcaccgctt atacaaaaat aataaagact 3930721 ggtccagcta tcttctgccg gcagccgtct tgatcacagc cgtgtttcag gtgtatattc 3930781 tgagcgctta tacaagccaa atcggcagtg tatggatgta tgtcctgggg ctcttaggac 3930841 tgggcatcac ccttgcactt ctgatgctta aacgcagcca tccgttcagt aagctgctga 3930901 ccatcatcag cttgtgcgtt ctgcttctca caccagttta ctggtcagca acgccgcttc 3930961 tatacggtgg caacagcgtc cttcctgaat ccggcccgca gctcaaaggc tcagcaaacg 3931021 gcgggaacat gttctcttca gaggtcgaca gcgggctcct gtcctatctg agaaaacaca 3931081 ataccggcga agagtattta tttgctactt tgacaaccgt aacagctgcg ccatacatca 3931141 tttacgaaaa tgaatctgtt atggcaatgg gcgggtttaa cggcacggat cccattctga 3931201 ctgtgtcgga actgaaaaaa ctgatcaaag aaggcaaagt gaaatacttc cttctgtcag 3931261 aaaacaactc aggcaacagc gaacttgttt cctggattaa gaaaaacgga aaagaaataa 3931321 catctgacga gtacagcggt tcctccagca gcacaaacag cgtgcaggga atgcgaagag 3931381 gacctggcgg agaaagccag caaactcttt atctcgtgga ataaaaaaag aggcttggat 3931441 gaatccaagc ctcttttcta ttaagcttct tcttttacat gtacctttaa cacagcctgc 3931501 acttcaggat gcagcttcac aggcacgttt gtatatccta atgcacgaat gccgtccggc 3931561 agttcaagct tccgcttatc tactttaatg ttatggtctt tttggagctg ttcagtgatt 3931621 tgcttgcttg tcactgaacc aaataaacgg ccgccctcac ctgattttgc gctaagctca 3931681 acagtcagtt tttctaatgt ctctttcaag ctcttagcct gctcaagctc agcaatggct 3931741 tcttttttct ctttctgctt ttgtccgttt aacgcgctga tgtttgacgc gttcgcttca 3931801 accgcgaggc cttttttaat tagaaagtta tgcgcataac cgtctgctac gtttttgact 3931861 tcgccttttt ttccttttcc ttttacatct tgtaagaaaa taaccttcat ctctgtacgc 3931921 ctccctcaaa atactcatct atggcgtgct tcagccgttc cagcgcttca gaaactgaaa 3931981 tgccggacaa ctgagtcgcc gcatttgtta aatgccctcc gccttccagg gcctccatga 3932041 tgatctgaac atttacctcg ccaagcgacc gagcactgat acaaaccgtt tgttcatccc 3932101 gtctcgccac cgcaaatgaa gcctcaacct cactcatcga tagcagcgaa tcggcagcct 3932161 gcgcaatcag cacttgatcg aagtattcct cttcattttc aggaagagaa gcaatcgcaa 3932221 tgttatcttt atagaggacc gtatgctgga tcagcttcgc ccgtttaata taggaatcaa 3932281 cggtttcttt cagaaacttc tgcaccagca ccgtgtcggc gccttttgcc cttaaataag 3932341 aagccgcatc gaaagtccgc gagcccgtgc ggagagaaaa gctctttgta tccactatta 3932401 taccagctaa tagggctgtt gcttcaatca tattgatttt taagcgcttc ggctgatatt 3932461 caagcagctc tgtcaccaat tccgctgtgg aagaagcgta tggttccata taaacgagca 3932521 gcggatctct gataaactcc tcacctcttc ggtgatggtc gatgaccacg atatgttcaa 3932581 ttttattgac cagccgttcc tccatgacga gtgacggctt atgtgtatca acgatcacaa 3932641 gcagtgtgtc atcattggaa atctccattg cttcttcagg cgtaataaat cttgaccaca 3932701 gttcttcata ttttttgatt tccccaatca aacgctgcac acttgatccg atttggtttg 3932761 ggtcaatcac gataaaacca tctttgttat ttgcctgagc cacctttaaa atcccgatcg 3932821 ctgcgccgat agaatccatg tcggggaatt tatgccccat gataatcaca ttgctgcttt 3932881 cggtgacgat ttcctttaag gcgtgagaaa tcacgcgggc ccgcaccctt gttcgtttct 3932941 ccattgggtt tgttttaccg ccgtaaaact tcaccttgcc gtttggcagc ttaatggcta 3933001 cctggtctcc gccgcgtccc agtgctaagt ccaagctgga ttgcgccaaa tcgccaagtt 3933061 ctttcaggga agagactgaa gccccgacac cgacgcttaa cgtcagcgct acaccgtcaa 3933121 acgaggtttt ttcccgcact tcatcaagaa tcgaaaactt cgaattttcg agttcagtta 3933181 agatatgttc attaagtaca gcaataaagc gttctgaaga cgtccttttc aagaagatcc 3933241 cgtactcctg cgcccaagcg ttcagcaaag atgtcacctg gctgttcatc gtgcttctcg 3933301 tctggtcatc caatccttgt gtcacatcat catagttatc aaggaaaata tatgccagga 3933361 cggttctttc gttttcatat agcttttcaa tctggatttg ttctgttaca tcaaagaaat 3933421 ataagagacg ctcatcccgt ttgatgacaa ccctaaactt gcggtcattc aatgtaaccg 3933481 tttccgattc cacctcttgt ttgataagcg gcactaccga ttcacaagta tcgtaaagtg 3933541 atctccccac taaagtgctt tcattaaaac aagaggaaag aaacggattt gcccattcta 3933601 tataatattg gtcattaaaa agcatgattc caatcggcat ttccatcaat gcctcttcac 3933661 cgactttttt caacctgtag gacaacgtag aaatataagc atcaatctct tgtcgaataa 3933721 gagaatcagc acgcttaata aaaaacaaaa taactgccag cagcagcact tcgacggttc 3933781 ctaatatcca gttaaaataa aagctgatga ggattgtaat aattgacaga gcaatcaatg 3933841 catagatggg ataccgaaac agcggttttt cataaaagct tggcatttct atcactcccc 3933901 accatgtgag taaaactcat gttcacttca ccttattcct tatatgaaag cccatatcta 3933961 aaacgcctaa aatgcgaatg gccgccatga agaccggatg cacaaaccca agtatgacag 3934021 caatcacagc cgcagccttt ggatattgtt tcttatggca atagaaaaag ataaatgata 3934081 aaccttggat gaaaatcaga aacccgagta taaactcccc atttaaagcg atagagtaca 3934141 gcatttggcc tttttctaaa ggcaaaaatg aaagcatgac aataatcaaa tacagtacta 3934201 caacactttg cggaaacttc aactctctaa aaggctttag attaggaata tcgggggaga 3934261 atcgccttaa gagcggctta gcgataaggt aactgaggaa agaaaaaata actcctacca 3934321 tcacaatagc tgttggaaaa agatattgaa cgatacccaa ttgttcttcc atcagtttta 3934381 attgcttctc aaactgccca gcattgcccg actgcttcgc tacagtttct acaatatcaa 3934441 gagattgccg gtattgtgtc attgcctcat caatgatatt gatacccaaa aactgaatgc 3934501 ttatcacaaa atagaagaca atactaagca tataaataag agcgcccgaa ataatggcgt 3934561 gcccgggctc tttccttttg aaaaaatgtc ccatggcaat gccggcgcaa gctgacataa 3934621 aagctacaat aagcccgtta aaggacccga caataaaaac aaccggaaga ctgacagcgc 3934681 ccatccatat ccctagcttc aatccatgtc tgatcgtata caagatcatt ggcagcggca 3934741 gtgcaaataa cagaattgtt ccaatcacag gaacataaac gaccagaagc gtaatgatcg 3934801 caaacagact gattaaaata gcaccttcca ttaaagctct cgtttgtttc acttagtcac 3934861 ctcgtatcat cctgaacata cgaatagaaa agagcagcat aaacgactgc tcttttgttc 3934921 atcgctgcaa catgctttgc accgaatgtt tttatatcat ctctaaattt tacttttata 3934981 ttttaacata agtccaaatc gcaagtaaaa tgacgctaat gtttcatgtg aaacatgaaa 3935041 aaggaaaaga cattctttga aaagaatgcc catcacaatt aatgtttatc atccataaag 3935101 ccagaagatt ccttgttttt ctttttcgtt tttctgacat acataaaaat taagatcacc 3935161 agtaaaaggg ttgttgcttg cagaacgccg ctgctaaaca agaaaaagtt ctttatcatg 3935221 tcccacattg tgtttcacct ctttgtgcat gttctcaacc cgtatcctat ataaggtgaa 3935281 tttccctttt taaaaacttc aaaacatcat gaacaacatt gagcgttggg catatgctga 3935341 tatggaatct gatcgataaa ggagaatttt cacatggatg aacgcagaac attggcttgg 3935401 catgaaacat tagaaatgca cgagctggtt gcttttcaat caaacggact cattaaactg 3935461 aagaaaatga taagagaagt aaaagaccct cagctcagac agctttataa cgtgtctatt 3935521 cagggtgttg agcaaaattt gagagagctt cttccgttct ttccacaggc tccgcacaga 3935581 gaggatgagg aagaagaacg cgcagataac ccattttaca gcggtgacct gctcggtttt 3935641 gccaaaacat ctgtccgcag ctatgccatc gcaattacag aaacagcaac acctcaatta 3935701 agaaacgtac tggtcaaaca gctgaatgct gccatccagc tgcacgccca agtttatcga 3935761 tacatgtatc agcatggata ttatccgtct tacaaccttt ctgaactgtt gaaaaacgat 3935821 gtcagaaacg ccaacagagc catttcaatg aaataaaaca agcagcaaag gagttccctt 3935881 tgctgctatt tctgctgatc cttcactaag ccgttcgaac gataagattc cagcacgtct 3935941 ctgttggatt ctccccattc tttcatttgc aaaacaatcg gttcaagcgt gcgcccaaat 3936001 tccgtcagag agtactctac cttgggcggc acctggtgat aaacctcacg gtgcacgatg 3936061 ccgtccgctt ccagctccct cagctggaga gtaagcattc tttgagtaat actcgggcag 3936121 attcgccgaa actcattaaa tcgtttcttg ccatctatca tgtgataaaa aagaattcct 3936181 ttccactttc cgccaatgac atctagagtg aattcaactg gacagccttc tttgttcggg 3936241 tatatattct ttttttcact cattcttgac cctccaatag tacctttttt gatactacat 3936301 tacattttgc aactaatcta cccagtattt tacacacctt ttctccttag ctcaaagaaa 3936361 atgcttctta ttcacatcaa tttttaaggg tttgcatgat tacacctgca gcaagacgtg 3936421 ttaaactata taaagattac actacttaaa aaaggatagg agctatcatg gaaaagatac 3936481 ttattttcgg acaccaaaac ccagatacag atacgatttg ttctgcgatt gcttatgctg 3936541 atttgaaaaa caaactcggc ttcaatgctg agcctgtccg cctcggacaa gtcaacggcg 3936601 aaacacaata cgcgcttgac tatttcaaac aagaaagccc gcgtcttgtt gaaacagctg 3936661 caaacgaagt aaacggcgtt atcctggttg accataacga acgccagcaa agcatcaaag 3936721 acattgaaga ggttcaggtt ttagaggtta tcgaccatca ccgcatcgct aactttgaaa 3936781 cagctgagcc gctttactat cgtgctgagc ctgtaggctg tacggctacc atcttaaaca 3936841 aaatgtacaa agagaataac gtgaaaatcg agaaagaaat tgccggcctt atgctgtctg 3936901 cgatcatttc tgattccctg ttatttaaat ctccaacttg cacggaccaa gacgtagcag 3936961 cagcaaaaga gcttgcggag atcgctggag tagatgctga agaatacggc ttgaacatgt 3937021 tgaaagcagg cgctgatcta agcaaaaaaa cagtggaaga gctcatttct cttgatgcga 3937081 aagaatttac actcggcagc aagaaagtcg aaatcgcaca agtaaacaca gtggacattg 3937141 aagatgtaaa aaaacgccaa gctgaattag aagctgtgat ctcaaaagtt gtggctgaga 3937201 agaatcttga tctgttcctt ctcgttatca cagatatctt agaaaatgat tcacttgctc 3937261 ttgcaatcgg taacgaagca gcgaaagtgg aaaaagcgtt caacgttaca ttagaaaaca 3937321 acacagccct cttaaaaggc gttgtttccc gtaaaaaaca agtcgttcct gtcttaacag 3937381 acgcaatggc tgaataagca aaaagcatcc cgcgtcggga tgctttttct tattcaccca 3937441 gcttctcaat ttgtcccatc acatcagtaa tttgctttgc gttttggacc aggtctgact 3937501 gctccaattc tttaagcgat accttgcctt cctcggcttg tttcaacaca tcttcagcgc 3937561 ttttctgcaa ggtttcgtta tgctcctgaa tggttcgatg aatctccgct gcggcatcag 3937621 gcggcgttaa ttcattaaaa tcagcggcag ccttctgaat cgactcaagc tgcgcttcaa 3937681 gtttttcttt cgcctcggtg tcatttacag ctttctcagc caattcaggc gcttcctctg 3937741 caaatgtctt caccttctcc acataaccag ctgcttcact cgtatagttc aatccgtcgt 3937801 tcacctgatc aagcatgccg catccgcctg cactcaaaag tcccactccg gcaagtactg 3937861 tcaaaatgat cttcatcttc agccccctca tcgtttcttt ttcatttttt cttttaagat 3937921 cggaatcaat ttctctttcg ctaacggcag ccctttcctc accaattcac gcttcagcca 3937981 ctttttcagc ttagacattc tgatgctcct ctcccttttt gataaaaatg aaaaaactcc 3938041 accaatttgg tgaagttcct gaaacaaaaa gaccttcacc aaatcagatt tggcaaaggt 3938101 ctcgctaaca atgagattgc cagcaaagcc gaggacacct tgtcccgtaa tgacgacttt 3938161 actgtgaaag ctactcccct ttggagtgtt catttttatt actttcattc taaagcaccg 3938221 atctgttcca gtcaaattcc tgccgtttat ataaaagcgc gctgtggtat ttaaaatttg 3938281 aatggttttt ctatcaggag atcatgctat gacagaggag gttttcatca tgagtcaaga 3938341 gcgcgtgaaa cggcctgggc ataccagatg gtacatatct tcgttactta gcggcattat 3938401 tattcttaat tattttgacc gagtggccat ctcggtagcg gcccctgcga tacaagattc 3938461 gtttcacctt actgcaactg aactcggcat cgtgttttcc atttacacct attcctatac 3938521 actgatgcag ctgcctgtcg gaagtttgct ggaccgtttt ggggtcgcat gggtcacgag 3938581 ggttggaatg acaatatgga gctttttaac gatccttctt gcttttttgc aaggaaaatt 3938641 gctgttgtat ctgttccggt ttctcattgg gctgacgagc gcctctgcgt tccctgctgc 3938701 ctctaaagca accgctctct ggtttcctcc aagtgagcgg ggattggcaa actcactgtt 3938761 cgattcggcc gccaagtttt caaatgtaat cggcgcgcca ttggtcgcct ttcttgtcac 3938821 aacatttgac tggcgtgtcg cttttttgac gattggatgc atcaatgtgc tgtttacgat 3938881 ctttttctgg cagtattatg aacagcctga acggcacaaa cgcatttcta aaagtgaact 3938941 aaactatatt caaaaacaca atgccattac aacagagcaa atcccttaca aaacgggccc 3939001 gcttttaaaa aagcttttca ccaatcgaaa agtatggggc ttaatgatcg gatttacagg 3939061 gtacgggtat acattcaacc tgctgctcac ctggcttccg actttcttta aacatacata 3939121 cggtatggat ctcatgtcgt ccggtttatt tacggcagtg ccgtggctga tctcaaccat 3939181 ttccggaatt gccgtcggcg gctggctcgt cgattatttt attaagaaag gctatcctaa 3939241 taccaaggtg taccgaaccg taatcatagt cggaatgagc tttggctttt tctttttagg 3939301 atccattctg acgaacaata ttaccgtagc cattatttgc atttccatcg gactcgccgg 3939361 aatttccgca accgctccgg tcggctggtc catctccgca gaactcgcgc cgatcggttc 3939421 cgtatccatg ctgagctcca tggtgaatct cgcaaacaac ctgttcggag gcattattgc 3939481 tgcgtcactg acagggtatt tgtttgatgt gacaggctcc tttaccctca gctttctggt 3939541 agctggtttt gtgctgttgc tgggattggt tttttatgtg tttgtattag gggatgtaaa 3939601 acgaattaaa ctatagaaca tgaaaaagag agctgccagt tggcagctct ccctttacat 3939661 caaagaatcg gcccgtcccc atttaccttc tcctcgtcct gttcctctat atcaagcccc 3939721 gaagctagca tttcctgctc tatctgttcg agcacctgct cgttttttcc ttgaagacca 3939781 ccttcataat gaaaagcatc ctgtgtgccg ttttcctcta ttgtcgctaa aatatcgtgg 3939841 atatcattat ggtctcctga aatggagccg aatccctggt tttgtttttt ataattcaca 3939901 aaaccgctgg ggaggttgtt tccgaggttt acacatgatg cgctccgagt agtaattcat 3939961 cagtgtatca aaatcttcat tttggattgc cacatcacat gcagagatga tgtctttcaa 3940021 ttgctgttcc aaatgaattc ccctaatcat catgattgga tatattatac aatgtttgac 3940081 acgtagggat ccttttcatt tttgttttta cggtttcgct ggtccatttc cgcagagctg 3940141 gcgccgatcg gttccgtatc catgctgagc tccatggtaa atctggcaaa caacctgttc 3940201 gaaggcatta ttgcggcttc attgacgggg tattttgttt gatgtgacaa ggctccttta 3940261 cgctcagctt tctggtagcc agttttgttc tgctgcttgg attggttttt tacgtgtttg 3940321 tcttagggga tgtaaaacga attaagcggg aataaagagt gcttgtagag aaaacgttgt 3940381 tctttctaca agctttttag ttttgtgctg tttttcaaga tattcagctg tcataaaaag 3940441 aaaatgagct cccacatacc ggctaggtat gtggcgttct tcttcatgtt ctggcatgca 3940501 gctgtgagga ggatttgttt gctcaccccc tgaacctgcg atagctaagc ccgtgcagtt 3940561 gttttgaacc tacaaagctt cgttctattt tttcttttct ttttttagag atttcctgaa 3940621 atagaaaagc aatcttttct aaccttttct ttatggtttt gccatacata ccgagtaacg 3940681 actttctggc gtttcgttga ttttgtgtaa tattctcaaa catatttcag gatttgattt 3940741 atatgaccga tagtctttgc gatcaattgt tgagtacgta agtgtatgct gattcaacaa 3940801 atgtatctgt attgttcact ttataatgaa atttccattt tggaagcaaa cccctgactg 3940861 ggtgataacg tctatgtgcg atggcaccaa aaacttggag gtcaaatagt cctttagaga 3940921 tgagagttgt taagtagccg gaatctagag cgacggcttc tacttgaaaa tcaaatcatg 3940981 caatttagtg atccaatcgg tcaaggtagg gcttggaaca gaatcatgga cttttctgga 3941041 gttgcaaact attaatcgtc ctcattaaat ttataataaa aatattctca attgagcaaa 3941101 tcgcccaccc tttttccttt ataacataaa atccaatact atcaataaaa ttctttacag 3941161 gttattacag ttaagatata atatagttaa tcttttacgt aaaaggaggt ttttattact 3941221 tgtgttgaag ttttaaatag gagtaactcc atctccccat tacggtcttc atttaatttc 3941281 atcctgagtt ttatttagtt agatataaaa acgaaaattt cacattattt ttaactaacc 3941341 gatagtataa aatatatatt gaaaggattg taaaattatg aataaattcc tgaagagcaa 3941401 tttccgtttc cttcttgcgg ctgctttagg catatcatta cttgctagta gtaattttat 3941461 aaaagccagc aatgataact ataaattcca tttacttgta ccttatggct atggtaatgc 3941521 ctattcaaat gatgcattta gacagaccac tcatacagat aatccttgga aagtaaattt 3941581 acagaaatcg gcagaaggta aaggtacaat catgacattt tggttgatta acacagggaa 3941641 tagtaaaatt ccaaaagctt ctaaaataca taacgtaaaa caaggaagcg gagctcatta 3941701 ttatcatgca aatagccagg gaagccatac atatgtagcc ttagcagttg aaaacaacaa 3941761 ttacagtgca agttcttatg gtatagatgg tgtatgggat gaagaaactt ggtaaacaag 3941821 aaccttctaa aaacgttggc accttttagc cacgcgaaaa aatttagaat gataatcttt 3941881 ttataagatt atcattttta tttattctat taagaattga gtgagaacat ggaaagtcat 3941941 atttatcgca ttatcaaaaa taaattaact ataataatat ttactataat catattaatt 3942001 ccttgtgttg atatatcact attgttaatg actaacacag aataccatcc tgcatatgcg 3942061 tttttccttt ctggcacttc cgtagggcat gcttcacaaa tgatcctatt atggtttctt 3942121 ccgctttatt ttttgttact atgtgctgac gattctatac aagattataa aacaggatat 3942181 cattacattc ttataagcaa agttggcaga aaaaaatatt gtttggaaaa aatatttacc 3942241 tcttttatca tttcattttt gacaatgttt ttgtcactaa tattaaactt tttattggtt 3942301 caggttttct tttttaaagg tacatttaaa aatgacttag accaaattaa attccctgat 3942361 aacagccttt atacttttag tatggcccat ccttatatag caattgtgtt attttctatt 3942421 atttgttgta ttatgtctgg atttgttgga gcacttggtt caagcctcag tttacttttt 3942481 cgtgataaga agtatgccta cccagcaagt ttttttattt ggttcgtact tatactaaaa 3942541 aacaaatcat taatgttttt attccaaccg tttacagaat acggttataa tgtacttctc 3942601 cctatcctat gtttgtctat ctttattttt ctaataataa tttctagtat tgttttatat 3942661 gaggcaaaat acaatgaaaa ttaaaagact actattaatt ttatgtttac tactattttt 3942721 agttacttta tggttcaacc agaaccacac ttatcttgga aagaattcta tcgcgtcatt 3942781 actatatatg aataatagta cattcggata tagttcaata tttgcatata ccttgtttta 3942841 tattgtcccg tttcttatgt tacttagtaa cttttttcat tcagaaaacc cctacaaagt 3942901 aatgaggatg gttaagcgta aaaattacta caagtctaaa attatggaga ttgggtttgt 3942961 ttctttactt ttttcttcaa tacatactgt tattaatatt acgtgtacac atattttctt 3943021 tagtaaaaac ttgttggtcg aagcaaactt tttatcaatt tgtttattaa acatgattag 3943081 tttagtgttt ttctacttat cagtaggtat tatgtttaga cttacatacg atctgtttaa 3943141 ttcagtagca ttagcaattt ttattgtgta tataatttta gatagcttgt atttcggcgt 3943201 taaattatta cttcctaatg gatattggga accctttaga gacttggcta tattcacaaa 3943261 tatgctcaat agatattggt caacttcaaa tcttataata gtttatatta gacagataat 3943321 aatagttttt attttttatt tagttggatc ttcaattttt ttgaataagg attataaaaa 3943381 atgaggatta aaggcttttt cataacttta gttgcgataa tatttcaggc gtcattatcg 3943441 agttataata ataataaaaa tgtctttcct tttttagatg gcataccaat aagcacctcg 3943501 ggtcattatg agtatcaaaa tattttattg tggtttgtac ctattgtttc cctaagtttt 3943561 tgtttctctg ggagtattag agatacatac atttcgtatg agcaattaaa gttagtaaga 3943621 gaacatagta gagttaaatg ggtaacatct caattcttaa taattacagt tgtactttta 3943681 atctttactt tatctcagat tgctatattt tatatttatt cacttgtatc tcttcataac 3943741 cttgatatta attccgttat caataaaaga tttgttatga tgacactcat gtattatcta 3943801 accttactta acttatttag ttttcaatta tttatggagc tttattataa atctcaaata 3943861 gcacaattaa atataagcgt ttatattatt ttttcgttaa ttttagcaaa gaagttagtg 3943921 caattaaatt ctccgaaagt tattcactac tttttaattc caaactacag taatggatta 3943981 agaactgggt taagctatta ttcccaatct ggaactgcta ttattgaacc attattaggt 3944041 ttgtttatta taatcatttt acagatttca atagttatat tatctgtctt aaagttcaaa 3944101 aaaatagata tgctaaaaag tgagggctta caatgattga ggtattaaac ctaacaaaaa 3944161 aaattaaaaa gactacagtt ttagataata tctcttatac atttgaaaaa ggaacaattt 3944221 atggactatt tgggagtaat ggttctggaa agaccatgct acttcgtgca ttatccgggt 3944281 taatagtccc tactgaaggg agtataacta ttaaaggtga acaattacat aaagatatct 3944341 cttttcctaa aagtgtagga ttaattatag aaaatatgca gttacttcct cagtatgatg 3944401 cttttactaa ccttaaaatt ttgtcaaaaa ttaaaaagat cgcatcagat aatgatatat 3944461 tagattctat tagtagagtt ggtttggaaa attttaatag tgtaaaggtt agtaaattct 3944521 cgttaggaat gaaacaacga ttaaatattg cacaggctat ttttgaaaaa cctgatatat 3944581 tgctacttga tgaaccaaca aatgcgattg atgaaaaagg agttgcattt gttcatgaca 3944641 ttcttttaca agagaaaaaa aggggagcta ccattattat tactagtcat cacaaggaag 3944701 atattatatc tttatgtgac attgcattag aaatgaatca tggacgtcta gaaacttcag 3944761 aaaaagtaat atataagaaa gatagttagt ttaaactggc tatttcttat ccaatgatag 3944821 actgcagaca agttcaactg ctgtaatgct agaaaatcca atgaaatgct gataattgcg 3944881 aagagatatg atcagtcaga aaacaaatct taaaaagaaa aagtaaattc atcaatattt 3944941 ctaataaacc tggcaaacaa cctgttcgga ggcattatag ctacttcact gacgggatat 3945001 ttatttgatg tgacaggctc cttacgctca gctttctggt gccggttttg tgttgttgct 3945061 gggattggtt ttttatgtgt ttgtattagg ggatgtaaaa cgaattaaac tggaataaag 3945121 agtgcttgct gaaaagcact ctttttctgc atcgaaagaa tacttaagat aagtcactcc 3945181 caaaaatcgt aacagtctga cggttaaaca taaacctctg cccgttccat tttaatacgg 3945241 tttgaacata tcccaatgag tcggcgttat accttcccgc tatccgctgg tacgccaata 3945301 attcgtatac gccgtctctg tcaaaatcaa ccggatacaa gcccgataaa ggattcaccc 3945361 atccttctat cggcattttt aacacacctt ggctgttata aatctcattc aaatattccc 3945421 tgcccttgta agtaaggtcg aggatatacg tttcgttttg ctgatgactg ataacgctcg 3945481 ctttatattg attttgatac ctcacactgt actttaattc atcattcaat acatctgaat 3945541 tgaaaattcg ccggaactgc ctgtttagat aggcaaacac atatgcataa atagcaccgc 3945601 cgcttccccc tgtgtccatt actactgcca catcctcaat cttgtcgcct gtcatatccc 3945661 ccagaaaaag tgacggattg tatcccatat tgttttgaag ctgaatccgc tgctcctgat 3945721 gggttctgcc atcacggatc accaatgtga tatttctcca taacgggctg ccgggcattt 3945781 gatttccagt tagaaagacc tcgtcaataa cgccgtctcc cgttacatcg ccgcgggtag 3945841 atacaatgat tgcacgtgag gagacaggct gccgaaatac gtatggatgt tgaacaagtc 3945901 ctctgccttc ataaaaccaa taaggagcca ttctgatgtc atacacattc aattgtgtca 3945961 ccttccctaa tcagctgaat gaatcattat atgcaggaat ggcacatcaa agacatatct 3946021 tacacaccaa ttaaatccgt accatatgaa ttatcaatta cacaaagcca ctcgccttgc 3946081 gcattctttt taaatacata ggtcgccctt ctttccatcg catactcgga gtccttttta 3946141 tccgaatcaa gcagtgtctg agaaagaacg agtaccgtgt cacctgcttc caacaggatc 3946201 attttccctt gtgtcgggac aatatgatga ttgaaatagt tcgcaatcgt gataaacgct 3946261 tttttgattt cttccttgcc tcgcgcgatc atgcccggct tcacaactaa aacggcatct 3946321 tccgaataat aattcatcag tgtatcaaaa tcttcatttt ggattgccaa atcacacgca 3946381 gagatgatgt ctttcaattg ctgttccaaa tgaattcccc caatcatcat gattggatat 3946441 attatacatc gctagaccac tgaaaccttg aaaacaaaat gaaaagtatc cttttttcct 3946501 atataatcaa atagatatat ttaacaaagt acccaagtga aggggtgaac attattgtct 3946561 gcggaagtaa cgttacatga caatatacat tatgatttaa gtgcggattg ccagcactgt 3946621 tttggcctgt gctgtgtcgc cttgccttat gcgaagtcgg cagattttgc ttttgataaa 3946681 gacgggggca cgccttgccg caacttacaa tcaaactatc aatgttctat acataaagat 3946741 ctcagagaaa aaggatttcg aggctgctct gcatatgaat gctttggcgc cggccaaaaa 3946801 gtatcccaaa tcacttatga gggaaaggat tggcgaaaca gccccgaaac ggccaaccag 3946861 atgtttgacg tttttcctat catgcagcag ctgcacgaaa tgctctggta tttacatgaa 3946921 gctctttcta tagatatagc caagccgatt cattctgaac tgagaaccac tttcgaaaaa 3946981 atagaaaggc tcaccagact cagcaaagaa cgcttgctga cactgcaggt ggacgagcat 3947041 cgagctgagg tcaatgaatg gctgttaaaa acaagtgaac tggtgcgtgc ccaagcccgc 3947101 catccaaaac tcccgaaaaa ggtcagccgg ggaagtgtcc tgatcggcgc gaaactgaaa 3947161 gggcttgatc tgcgaggagc aaatctaaga ggggcgctgc tcatagccgc cgatctgaga 3947221 aatgccgatt tgagaatgac agactttatc ggtgcagata tgagagacgc tgatctcagc 3947281 ggcgccgacc tgaccgggag catctttttg acacaggcac aggtgaacgc cgccaacggc 3947341 gattcgaata caaagctgcc gctgtctgta cgaacccctg cccattggaa ataaaaaagg 3947401 acccgctaac ggtccttttt tactgatcaa ttcaatcctt tttcgttcct cttatccggc 3947461 attttcacac ttcttgccaa gtatcccgac agccataacg caaccagcag catgaaggtg 3947521 atcataccga cgacgcccag ccagtgaaaa ccagaccaga atagccctcc gattgttccg 3947581 aaaacacttg aaccggcgta ataaaagaac aaatacagcg atgaagcctg tgctttgttg 3947641 tgaagggctc tcctgcccac ccagctgctg gcaactgaat gccctccgaa aaaaccgaat 3947701 gtaaagaggg caatccccag aattttcact gccagcatat tgtttatcgt aaataacgca 3947761 cctgcaatga cgatgaaaat attcatcacc aatattttcg gatagccata ccgatcaacc 3947821 attcttccaa tgaaagacga gctgaaaatg cctacaatca tcacaataaa gatccagctg 3947881 gaaaatgctt tattaagcga atacggcggg cccaacagca catacacaat gtaattaaac 3947941 aaggcaacat tgcttccaag cagcaaaaaa ccaatgagaa acaagctgaa tagtttacgg 3948001 tccctcaagt ggccgatcag agacattccc aatttcccga gcttcaattt tcttggcgta 3948061 aaatgcctgg atggcggcaa atttataaaa aatataacac tagcaatcaa actaatgaca 3948121 ccaattgtcc ccatcgccat atgccaattc aagtactcgc tcaggagccc ggaaacgatc 3948181 cttccgaaaa cggcgccgat tgcatttccg ctgatatata gccccatcgc tgatccaaga 3948241 cttccgggtt caatttcttc cccaagataa gccatcgcaa tcgacggaag gcctgcgagc 3948301 gcaacgcctt gaatggttct caatacgagc agtgtatgaa agctcggact aaaggccgat 3948361 gccagacaga gaaccgatgc ggccagcatg gaaataccca taataggctt gcgtccccac 3948421 acctcggata atgaaccaaa gacaagcatg ctcacagcta acagcattgt ggtaacagat 3948481 aaagaaagac tcgccgcagt aggcgttaca tgaaattccc gcgtgaattc ctccatgagc 3948541 ggctgtacgc aatatagaat cgcaaatgta ttgaaacccg cagcgaagaa agcaaacgta 3948601 atttttcgaa aaaccggtgt gccttttcga atgtatgtca tcgggacttt atcggtccct 3948661 catcatgttg tggagcactg ccattcataa acaatcatcc tttatttctt acgaattcaa 3948721 acatcctcga gtctgtttat attattatct tagcaccgtt gatatatgtt gtataatgca 3948781 tataaaatat ccttttcatg cttatatgta ataaggagag atgataattg gaatgggaac 3948841 aacttgaata ttttcaaaca ctggcccgga tgcagcacgt cacgaaagcc gcaaaaagcc 3948901 tctccatcac acagcctgca ctttcacgct ctatcgccag gctggaaaat catttgggcg 3948961 tcccgctatt tgacaggcaa ggacgatcca tcagcttaaa tcaatacgga cacatttttt 3949021 tacgacgggt tcaggcgatg atgaaggagt ataccgaagg aaaagaagaa atccaagcct 3949081 tattaaagcc agaccaaggc gtagtctctc tcggtttttt acatacatta ggcaccacgc 3949141 tcgtgcccga tctcatcggc tcctttcagc aggaataccc caacatttcc ttccagctga 3949201 agcaaaacca ctcttattgg ctgcttgaac gattaaaatc cggagatctg gacctctgtc 3949261 tcctcgcttc gattaagcct gaaaatccga tccaatggat caagctgtgg agtgaagaac 3949321 tctttgtatt tgtgccaaat gatcacccat tagccagtcg cgaaagcatt accctgaatg 3949381 agattgccgg ggagcgtttt attttattga aaaagggcta tgcgcttcgg atgacggtcg 3949441 atgagctgtt tgagaaggcc aatatacagc cgaacattat gtttgaagga gaagaagcaa 3949501 ctactgccgc aggttttgtg gcagccggtc tgggcatatc tattctccca gacctgaaag 3949561 gcttagacca aagcaaaatc accaaaatcc gcgtcagctg gccggaatgt cagcgtgtca 3949621 taggaattgc ctggataaaa ggcaggtttt tatcaccggt tgctgagacc tttaaacaat 3949681 atgtgatcag ccatttttct gagtaggaag gattcaagca tgaatgtcaa aaaaatcacg 3949741 tcagaacagg atttacatac agcgtttgaa atcagaaagg cagtatttgt agaggaacaa 3949801 ggctgtccca tttcggatga attcgatgag ttcgatacac tccacggtga ctgccagcac 3949861 atcctggctt atcatcagaa tgtacctgtt ggcactgcac gtgtccgtat cgttggccac 3949921 acggggaaac tggaacgaat ctgcattctg aagtcttacc gcaaattcgg tttgggaaaa 3949981 gtgatcgtcg atgcattaga acgtattgta aaagaacaag gcatttctgc cttcaaactg 3950041 cacggccaga cacaggcggc aggcttttat gaaaagctcg gctatcggac tgcatcagaa 3950101 gaatttatgc tggacggcat tccgcatgtg ctgatgacaa aacaagacga ttctgcgcta 3950161 tagattgttc acaaatttgt cacttatgag catgaacggt tcattggtat actaatcacc 3950221 gattatggag agaaggaatg attgtatgcc agcaaataaa aaagaaggcc ttatatttgg 3950281 cgtgatgatg tgctttggaa tggtttgcgt catgtcgatt tacaatgcca tcatcaaccg 3950341 agccatctac gatttttcac tgatgaccgt ttttgaaatg gtcatcggtt ttatgatcgc 3950401 cctcctgtta gatttactgt tagtgggccc cctcgccaag aagattgcat tccgcatgcc 3950461 gttcgacaag actaaaaaaa tttatgtcat ccttgccatg tcaacttgta tggtgattgg 3950521 catggtactt tgtatgtctg tgttcggttt agtgacagcg gttctagcaa atgggctgaa 3950581 cggggacagc ctcttcagtg cttatcttat gattgtgttg aaaaatttca tcctggccta 3950641 tccgttgcaa ttactgatta tgggcccatt agtcagagga gttttcatga aatttgtaaa 3950701 accaaagctc acagccgcaa tttaaataga aaaggagtga gcctgacact cactcctttt 3950761 gctcatgaat cgaatgtaaa acaagctccg caaaagcctc tgcggcaggc agctgccatt 3950821 ttttcttttt gggtgtgagt aaatcggatc gagggcttca ccatgctgga gatttttcag 3950881 cttatgtttt tcacttccat taatccctat accttaccac atagttttta tacaattctt 3950941 cgttataaag gatttcttcg ccatgtgaag agcaaatgag cgttggtttg atttgatcta 3951001 tgattgagcc gctgtcgatg ttctcattta tatcaacact gaatcttctt ataggtgggt 3951061 gtaaatcctc cttacttgtg ataaaaaggt cgcccgtcaa tagcgtacga tcgattttat 3951121 gataatacac aacatgcccc ggcgaatggc caggtgttaa atagtatttc agaggcagat 3951181 gagcaagcgt ttgctccgtc agcggctgta caatatgggc tacccctgtg ttctccactt 3951241 catttttgtt cggatatggc tcttccccat tgatgtactt tagttctttc tggtgcgcaa 3951301 aaatcggaat atcaaatctc tctaaccatt ttgatgcacc cccgatatga tcactgtggc 3951361 catgggtaag caaaatggct tttggattgc cgatcgctaa cgctgcccta atttgagcat 3951421 cagcaaaacg ttctattccc gtatcaacaa tataaacatc atcaccatct ttgataaacc 3951481 aggtatgaac cggaatacga agaggcacat caagctcaaa ttcacattga aagacatgtt 3951541 ctgatagttg tctcaaattc acgcaaacca tctcctgtgg aaattttttg atagttttaa 3951601 agaaaacaga agtgaacgga ctattttcac ccacgctcga gctgactgga ttcttgagag 3951661 gaaacgccga ttttcgccag catcagctca acttgttaac gttgtccatt aataatccct 3951721 tttgttcccc ttcttcacat attcccaatc acgttctata ttcttcctca ctctatgaag 3951781 gagtgcagaa atggtttcct tttcctctga agtaaaaccg gacaaggcca cttccgtgga 3951841 atgttctcct tctcttctta acaatggata tacctttttc cctttctcag tcgggaacag 3951901 tttttttatt tttttatttt gctcatccgg cagtttttga ataaatccct gcatttccag 3951961 cttcttaatg gcccgcgcgg ccgttgtccg gtccactttt atcatttccg ccaatttttc 3952021 ttgaataatt cccggatttt cgtatatacg cacgagatag agatactgcc ctcttgttaa 3952081 gtctaaatct ttaaattcga tgttgcttat ggaatccaac gctcttgcta tcatgccgat 3952141 ctcacgcaaa atatcattca ttcctaaaac ccctcacgta tttttgttgc aattacaaca 3952201 aaaatgtttt aaccttacta ttataagacc acatgcgtgc tgtacagtcc agactaatat 3952261 cagaaaagga ttgattcata atgaatataa aaagaataac aactgaagct gatttacatg 3952321 aagctttaaa gattagaaga ggcgttttca ttgaggagca acatgtgtct gaagccgatg 3952381 agttcgatga atttgatacg cttcaggaac aatgccagca tatcttggta tatcatgaga 3952441 atcagcctgt cggcaccgga cgcgcgcgca tcgttggcca tacagcaaag ctggaaagaa 3952501 tctgcatcct aaaaccttac cgtaagtacg gattggggaa gatcatcgta agcgggttag 3952561 aggaaatcat gaaagaaaaa ggactgactt catataagct gcatggtcaa acacaagcgg 3952621 caggctttta tcaaaaactg ggctaccaga tttcttcaca ggaatttatg gaggacggca 3952681 tccctcacgt cttgatgaca aaagaaatat cgcggaatat aacatgaaat atatgtatta 3952741 cggaataggc atactcatat taagtttggg catttcctta accatacaat caggactggg 3952801 cacatcaccc ttcgatgccc ttttggttgg tctgtcaaaa aaaatcggtc ttaccgtagg 3952861 aagctgggag gtccttattt ctgtgatcct cttaatctgc aacgctatat taacgagaaa 3952921 aaaacctatt ttgctgggct tgattacagc attcattact ggaataggca ttgacctatg 3952981 gttgtttgtt gtaaaaaaca ccatctatct aaactcgttg ttaagcaaac tgatttgttt 3953041 tggaattggt ttggtgctca tcggtcttgg aacagccatc tatcttcaga cgaaattcgc 3953101 atcaacaccg atcgatcatt taacacttat tatccgagat ctctccaaaa gaacaatatt 3953161 gttttcaagg acattggtat acgctctttt cttagtatta gccatcatct ttaaaggccc 3953221 tatcggcatc ggaactcttt taacggtttg tttgggagga atgctccttc acgtttttat 3953281 gcctattgtg gaaagacatt tcttatcaaa gaatagaaga ggttattaag aaacctcttc 3953341 tcgatccaaa aaacgaaacg caaaacaagc cccgtttcgt tgtcaattct ttatctctgg 3953401 tactgttgag gttttataat caattaaaat ttatagtacc aaaaaatcgc aatttcattt 3953461 gctgttggaa agttggaata aagcatcgta tcaaccgcac ctattataaa gtgatgtttg 3953521 gcataaaaat gacaagctga aatattaata tcttgggttt caagcataag accacaaaaa 3953581 tgattctcct ttgcccactc aatcgcttta tgtaataatg ctgttccaac accttttttt 3953641 ctatagtctt ttgccacggc aatgtcctct attagtgcat acccattcca gttagaacgg 3953701 atcttaatcc ggccaatgca gttgttttca agataatata aaaaagccgc tttcccctct 3953761 tcttcaacat aactaacatc catgtcatca tcttcatatt gtttaaaata aggtttagaa 3953821 aatcgttcct cagtatatgt ccaaacaccg ttttcaaaag caggtatcat tctcccaaaa 3953881 acaacgaaag gttcgtttgg tttattgaaa tctttcatat tcaaatgagt cattttcatg 3953941 atcatatcaa tctccgccaa tcgagataat atttagtaaa ctcgtttcga tactattcaa 3954001 caacagcttc caaaagtgta ctctttaaga gaacagcatt agataaggca tccattacct 3954061 tatatatttc actatcttaa tgaggtattt caacagaggc ttgtggtaca gtaaaaagga 3954121 atagaaacaa gagaaaagaa gatgaaccta tgcccactaa caataaactc aatgagaaat 3954181 atcatacttc cttcaactcg cccacaaccc tgttgactag tatccgtgga gagaggaagc 3954241 tttgacacag cttctgccat tgatgacatc tctattgaag tatccaaagg acaaccaagg 3954301 atcgctcttt gactttttca agaagaaagt agagtgaata aaggagtgat tgagtatgtt 3954361 aacaagagaa gatatcttta aacacgtcaa agaaaaatac ggtacatcgc ctgattaccc 3954421 gtgggagaaa tacccaaact atgcttcttt gagacataca tcaaacaaaa aatggtacgg 3954481 tcttatcatg aatgttctcc cagaaaaatt aggcttggat ggtcatggcg aaatagatat 3954541 tctaaatcta aaatgtcccc ctgaaataag tgatcgctta agaaacgggg aaaatatctt 3954601 acccggatat catatggata aggaacattg gatttcaatt gttttagaac ggacagatcc 3954661 agaaggcgaa atctataact taatcgagca gagctttcat ttaaccaagt gaagataaag 3954721 agtgttcctg ctaatcaagc tgcgaagagt agtgggcact ttcattttag gatactgttc 3954781 ttcactctgt ccacaaacgc aacttagttc atctggtgcg agagtgggag aagaatttca 3954841 accaacttct tatgtaaaag gatgaatagt tatgacaaat aacttaaaac agagaagaat 3954901 cattttagat ttagcagtta ctttagatgg ttttattgaa gggaaaaatg gagaagttga 3954961 ttggtgtatt atggaccctg atatggggtt tactgatttt ttaaatcaaa ttgatactat 3955021 tttatatggt agaaaaagct tcgatttatg gggacaatac attccaaaaa atgaagaccc 3955081 tgatacagaa aaggaacttt ggaaattggt tcatagtaaa aagaaatatg ttttttccag 3955141 aacacaaaat gagattgata atcaagccat atttataaat gataatattc ttgaagaagt 3955201 aaataaattg aagaaaaatc ctggtaaaga catctggcta tatggtggag cgagtctcat 3955261 tacaactttt ataaatttgg ggcttgttga tgaatttaga ttatctattc accctgttgt 3955321 tttgggagaa ggaaaaccgt tgtttattga tgtaaaacag aggataaatt taaaaatggt 3955381 gaatacaaga acattttcct ctggcgttgt gcaaatcgtt tatcattgga atggctaaca 3955441 ttgtaaagta acactcgaca gtaatccttc ttattgaact aaaggggaat ccataaataa 3955501 tgggttcccc ttaatatact atggaattat caatatcaaa ttttctgtaa taaaagagga 3955561 ttgaaaagga cgatgtctcc tcaattaaca tcattaagca ttatagtata ttttcttctc 3955621 cctcttttaa gtaatcggct aagttttgta tttataaaaa aacgaaagaa ggtgatccaa 3955681 tgcctactaa caataaaccc aatagattaa tcgctgagaa atctacttat tttacttcaa 3955741 catgctcata accctgtgga ctggttccct tggggagaag aagcatatga aaaagcgaaa 3955801 cgcgaaaaca agcctgttct cgtatctatt gggtatagct aacgatggct aatctaaaga 3955861 acatgctatt gatgccatgt ttattcattt tacaaaaaag gatcaacctt gaattacttt 3955921 cacaagattg atcctttcac tcatttagcc atgtctccgc gaacgtttat atacattcaa 3955981 gattactagc caacaaataa caatgattcc tgcaaaaagt atgagcatat tgctatacaa 3956041 ataggtagag tgatcaacgt caataggcag cagcctatga tctaggaagc cgatagataa 3956101 taaaccgcct acaatcgcaa tacccgttcc ctctgataaa aagctcgtga aattaagcaa 3956161 actcattcca gcgcccgctt ccttttcttt caaactgcta gacacaactg tagatataac 3956221 tgtttttgtg aaagatagcc ccccaaaaac aaaaattact ataattgtca tgatccatgg 3956281 tgctgcatct ataaaaaagg cagcgattaa aaagccggaa gaaagcaatg cacttccaat 3956341 agttagtaca tacaaggaac ctttccgatc aacaagcaat cccccaatgt aaccaaagat 3956401 gatgacactc attgttccgg ggaaaataat gccgcttcca attgctgcag tacttaaatg 3956461 gtgaacatct ttcatcatgt aaggaaccat agagacaaat cctgctactg taccaaatat 3956521 tagtcctccg caaagggttc caatcacaaa aaagacgttt ttccctaatt cagggtcaac 3956581 aaaagggtcc tgagctttcc taatgtgttg cacaaatatg aagaaagcaa ggatactgat 3956641 gatcagaaaa gaaaatctat aagatgttgt aaacagcata aaaaatacga tacctgcaga 3956701 catcaatata atccctgcca tatcaatgtg tcctcttatt ctctcttcct ttttcaacaa 3956761 ttttataagg aatggaacgg tgataattgt tgcagttgga ataagcagca aatacgacca 3956821 atggatataa tgagcaacca ttccgccaat agctggccca acaccttctc ccattgctac 3956881 cagggacccg atcaggccaa atgctttccc cctgttctct tttggaatat agcgcgcaac 3956941 gacaaccatc acaagagctg ggaatgcggc tgcaccaatt ccttgaataa atcgggctag 3957001 aatgagaata ggaaagaaag agtgtccaac aaatccaatg atcgacccta agccatttac 3957061 cataatccca aatagaagca gatttttgat gcccagctgg tctgatagct ttccatatag 3957121 agctgttcca atggagaagg ttaacataaa ggctgtattc acccagtttg cacttgctgg 3957181 cagtttatta aactcgttgg caatatcagg taatgagacg ttcagaacca tttcatttaa 3957241 tacgctgaaa aatgatagaa cacaaagcca aatcaaaact tgattgtgcc gtaaagttga 3957301 ctgtgaataa gacgtattca caatttcccc tccattaatg agggcagacg cagtttatag 3957361 ggtcattgat acgcttccct cttttaattg taccctgttc attttattgc acttcataat 3957421 aactccccct acatttgatt gatatgatct tattatatat agactaagga ttaaactttt 3957481 acttttttta taaaaatttg accagattgc gaaacaagga aaaacgttat tcgcatttat 3957541 ctcaagtggc aaaatgaaac attagtttat attttcacat cacaattatc gataagcagt 3957601 cagttattgt atttgtttag gataactgtg gtaacctgaa tataaccaac ttaggaagaa 3957661 ggtgatccca tgccaaataa aagtaaaccc aatagattaa tcgctgaaaa gtctccttat 3957721 ttactccaac acgcccacaa ccctgtggac tggttcccgt ggggagaaga agcatttgca 3957781 aaagcaaaac gcgaaaacaa gccggttctg gtcagcatcg gttattcgac gacttgtcat 3957841 tggtggcctg ggataatcaa atcgtgtgga actccattaa aagataacag aagccatttt 3957901 aaacgataat actatttgtt caaacaatac agtctacctt ttatttcatt cattttctaa 3957961 aacctgtaat ccgtaaccac gcggtagcag gtttttttat ttgcttgact tagagttaac 3958021 tctaaattgt aaactaactt taattaaatg agagggatga tgttgttgta ttccattagt 3958081 aaagctgctg agaagactag tattagttcg tatacattaa gatattacga aaagattggg 3958141 ttacttccac caccaaaacg aaaaaacagt ggaaggcgtt tttatacgga gactgatatt 3958201 cagttcatgt tattcctgaa aagtttaaag gaaacaggta tgtctttgga ggatattaat 3958261 gagtttgtca aagacggatg cattttggaa aaaatcaatt cggatgttaa atcggcacaa 3958321 ctctccccat ctataaataa acgtattgag attttaacca agcacttaga gaaaatggaa 3958381 attaaaaaaa gggagctgga agaagtgatt tctactacaa aaggaaaact ggatacatat 3958441 tattcaattt tgaaagagga agtggaaaac aaatgaaaca tttaaatata tacataatgt 3958501 tacttggctt ctctattttc acgggagcta cttttaatct tgcaaaatat acagttggat 3958561 atttttctcc atcgtcttct gcggcatggc gtttcggttt agcggctgca gtgatgctca 3958621 tcattttgat ttttactgaa ggtataaaga agagtcaatt acggaaaaac gccgtttcat 3958681 acattgttct tggaattata ggaatctttg gatttaatgc cttgtttttt gttggtttaa 3958741 aatatacatc tcccgttaac ggagcattaa taatggggct gaatccttta ttaacagcaa 3958801 ttctcgctcg aattatctta aaggacaaca tgacaaaaaa acaagtactc ggcatattct 3958861 ttgcattcat cggtgtattg ttagtcatta cacaaggttc tatcgaaacc attaaaacct 3958921 tatcaatttc aggaggagac ttaataatct ttacaggtaa cgtttgttgg gcactttatg 3958981 gcgtacttgg acgtcggttt gtaaaggatg gtacaccgct atctacaacc acttatacga 3959041 tggttattgg tgctgttagt ttaatagtag tttccttatt tacatccaaa cctgtttctt 3959101 tatcgaacat cccgattgga gtttgggggg caattgcttt tatggctttt tttacaagtg 3959161 ttttgggtta cctatggtgg aatcagggga ttaaagagat tggagctagt aaaacatctt 3959221 tatttttcaa ccttgttccc gttgtaacga tgattatttc atttgccgtt ggaacaccaa 3959281 taaaggtatt tcaagttatt ggggctgtgc tagttatatt aggcgtttta accgcttcgg 3959341 gggtaatacg tattcctaag tacaatacta aagaacagtc agctatataa agaaataggg 3959401 agtatttttg agaaaatgtg ttaagttaaa tatacactaa ttataggaag aaggtgatcc 3959461 catgccaaac aaaagtaaac ccaatagatt aatcaatgag aaatcaccat atttactcca 3959521 acacgcccac aaccctgtgg actggttccc gtggggagaa gaagcttttg aaaaagcaaa 3959581 acgcgaaaac aagccggttc tggtcagcat cggttattcg acttgtcatt ggtgccacgt 3959641 gatggcccac gaaagctttg aagacgaaga aatcgcgcgt cttctcaatg aacggtttgt 3959701 ggcgattaaa gtcgaccggg aagagcggcc tgatgtggat tctgtttata tgagaatctg 3959761 ccagctgatg accgggcagg gcggctggcc gctgaatgtg tttatcacgc ctgatcaaaa 3959821 gccgttttac gcgggtacat attttccaaa gacgagcaaa ttcaatcgtc ccggttttgt 3959881 tgatgtgctt gagcatctgt ctgagacgtt tgcgaacgac cgcgagcatg tcgaggatat 3959941 tgcggagaac gccgctaaac atttgcagac caaaacagct gcaaaaactg gtgagggcct 3960001 tagcgaatca gcgattcacc ggacattcca gcagcttgcc agcgggtttg acacgatcta 3960061 cggcggtttc gggcaggcac cgaaatttcc aatgcctcat atgctgatgt atttgctacg 3960121 ttatgatcac aatacagggc aggagaacgc tctatacaac gtgacgaaaa cattggacag 3960181 catggcgaat ggcggcattt acgatcatat cggctatggg ttcgcccgct attcgaccga 3960241 tgacgagtgg ctcgttcccc actttgaaaa aatgctgtac gacaatgcgc tgctgctgac 3960301 cgcttataca gaagcctatc aggtcacgca aaacagccgc tataaagaga tttgtgagca 3960361 gatcattacg ttcattcaga gggaaatgac tcatgaagac ggaagctttt tctcggcttt 3960421 ggacgcggac acagaaggag aagaaggaaa gtactacgtg tggtcaaagg aagagattct 3960481 aaaaacgctc ggggacgatc tcggaacgct gtattgccaa gtgtatgaca tcactgaaga 3960541 aggaaacttt gaaggcaaaa atattcctaa cctcattcac acaaagcgag aacaaatcaa 3960601 agaggatgcc gggttaaccg aaaaagagct cagtctcaaa ctcgaagacg caagacagca 3960661 gctcttgaag acacgcgagg aaagaaccta tccgcatgtc gatgataaag tgcttacctc 3960721 atggaacgcg ctgatgatcg cgggtcttgc gaaagcggca aaggtatacc aggagccgaa 3960781 atatctcagc ctagcgaaag acgccatcac atttattgaa aacaaattaa tcatcgacgg 3960841 ccgtgtgatg gtccgatatc gtgatggcga agtgaaaaac aaaggcttta tcgacgatta 3960901 cgcttttctc ctatgggctt atctggatct ctatgaagct tcgtttgatc tttcttattt 3960961 acaaaaagcg aagaaactga cagacgatat gatcagctta ttttgggatg aggagcatgg 3961021 cggattctac ttcaccggac acgatgcaga agccttaatc gtacgggaaa aagaagtgta 3961081 cgacggcgcc gtgccttcag gaaacagtgt ggcagctgtt cagctgctgc gtctcgggca 3961141 agtcacaggc gacttatcac tgatcgaaaa agcggaaaca atgttttccg tgttcaagcc 3961201 agacatagaa gcgtatccga gcggccatgc tttctttatg caaagtgtgt taaggcatct 3961261 gatgcctaaa aaagaaatcg tgatttttgg cagcgcagac gatccagcca gaaaacaaat 3961321 tatagcggag cttcaaaaag cctttaagcc caacgactcc attctggtgg cagagcagcc 3961381 cgagcaatgc aaagacattg cgccatttgc agcagactac cgcatcatag acggcaaaac 3961441 aaccgtttat atttgtgaaa acttcgcctg ccagcaaccg acaacaaata ttgaagaagc 3961501 gatccacaca ttaataagca gcagggatta agacccttgc tgcttacttt ttgatttctt 3961561 atggtaccat aaagcgatcc ccgcaaacac aaggttgacc gctatcgtaa agaaagcctc 3961621 ccacatcggg ttcccccgcg taacggtaaa cagagaagga attcctccat acacactgtt 3961681 tttttctgta ataaacatac acaaaaacat attattcgcg gcatgggcgc caagtgatat 3961741 ttcgatgctc ccagttttaa tcgtgtaata cgtccacaca aacccaaatg ttaagtactc 3961801 aattcctgcc cagacagcgc cattgttcat ttctggattc gcaaaatgca atacgccaaa 3961861 caatcctccg acaatcagtg tcaaaaatag aggatttttc gtcaatctcc cgaaagcttg 3961921 aagcaaaaat cccctgaaaa atagttcctc agctgatgtc tgaatcggaa ccaaaatgag 3961981 ggcagccgct agcagccaga taaatcgtga tgcattaaac tcttgcattg aatagctatc 3962041 aggatgaatc acaaaatcaa tcaattgtac ggcgatcatt agcaagaaat aagcaataaa 3962101 accaaaggaa attctccgcc aattcatctt tgaatttggt gttatcaccg ttcggaaagg 3962161 ccgcttcaaa ataaagcgca cagccagcca aactcccgga atggcgaata aataaatcac 3962221 atgggacaaa taaagatcta cgaggggatc actcagcaca gcttcatcca aatcaaacgt 3962281 gatattggga ttcacaataa ccgtgaacaa tatagcgaaa aggtaagcta tattccctaa 3962341 tacatataac cctaccatca ccaaaaaagc gaaaaaatat ctccacaacg tattgtttcc 3962401 ttctatagga cggataaatg aattcattcc ttctatgtct cttcctttca atgagaatat 3962461 tactatatat ttgcataaat tggtctatga atctactgtt ttggaaatct tttaagcaaa 3962521 attaaaatat aaagtgtgaa tttagttctt ccatctagtg atttgaactc tgttgccaat 3962581 gaaccaagat acttataata gtcccaagag gggaattttc agtcttttct actactcaaa 3962641 agggggtttt ttatgaatac gatcttcaaa caaaagaata cacatccttt ctcaaacgca 3962701 gcgaatcgtt tagaccgcct tccgatttca cgcgttcatt tccaagtgtt aaccgctctc 3962761 ggcattgttt atttctttga tctcgcagat ttatttaccc tcagcaacgt agcgccggca 3962821 ctgatcgagc attggggcat cccgctttca actattgcta acgtaacggc cgcttcgttt 3962881 ttaggcatgt ttttaggcgc ttcactgggc ggacggctgt ccgatcgaat cggccgcaaa 3962941 aaagccttaa atctatttgt ctttgttttc tcaatcgcat cgctatgcaa tgctgcggca 3963001 tgggacattc catctttaat gacattccgt ttcctcaccg gatttggcgt tgcagccgcc 3963061 atggtcatta cgaatagcta tttggcggaa tttttccctt caagtgtacg tggaaaatat 3963121 atttcttttt gtgccatgat tggattgatt ggggttccga tcaccaacat tgtgtctgcc 3963181 tttgtcattc ctcttggttc atggggatgg aggctagtat ttgtatgggg tgccgtcggc 3963241 cttatttatt ttttcttcat ccaccgtctg gaagagtcac ctcgctggca cgaaaatcgc 3963301 ggggaatatg cgaaagccga tgcgatcctc acccgaattg aagaacaggt tgaaaaggag 3963361 aaaggcccgc ttccggcagc atcccagcct aaagtaagcg aaactgttaa gcagaatgca 3963421 ggttacgcag gcttattgaa aggcagaaac ctcaaaatta ccatcgtatt atctgctgta 3963481 tggatttttg aaacgtttgg gttttacgga tttgcttcat gggttccaag cctgctaaaa 3963541 agcaatggcg taaccatgga aaatacatta tggtataacg tattgcattc cgtcggcgct 3963601 ccacttggcg cactgctcgg ctccatgatt tccgaaagat ttcaaagaaa atggatttta 3963661 gctgcgagtg cgtttctgac ggccatcgcc gggctcttat atggtatgac ttttattccc 3963721 atcatgatca ttgtatttgg ttttatcgtg aatatcacag aacgggtctt tacctcgaac 3963781 ttatacgcct atacatctga accttatccg actgaatacc gctcgtctgg cagcggttta 3963841 gcctatggtc ttggccgttt ttcaaacatt tttggctcat tgcttgtcgg atttattgcc 3963901 gttcagctcg gctatatcag cgtcttctta tttattgggg gctgttggct cgcatgctcc 3963961 ttgctgttaa tcttcttcgg tcctaatacg aatgcaaaac agatttaaaa aagtcagtgc 3964021 ggatctgccg cactgatctc attacaattg cttcaaaatc cttgcggggt ttccgcctac 3964081 aacagtatta gcgggtacat ccttagtgac aacagatcca gaagcaatca ctgcgttatc 3964141 accgattgtc actcccgggt taatcaccgc ccggcctcca atccaaactt gatctccaat 3964201 tgtcacaggc ttaccgaact ccttcccgga tttcctttcg atcggatcaa gaggatgacc 3964261 ggccgtgtag atatgtacac ctggcgcaat caaacaatga cagccgatac gcacctcaca 3964321 cacatctaaa atgacacagt caaaattaac aaatgtatga tctccgatat gaatgtgata 3964381 gccataatca cagcggaatg tcggcaaaat cgtgacttga tccccaaccg aaccgagcag 3964441 ctccttcaaa agcttcgtcc gcactgcatc atcttccggt gtttcgttgt attgtctaat 3964501 cagctgtctc gcatgcttgc gttctagtaa tagttgttga tcttccgaat tgtataattc 3964561 tccggctgcc attttttctt tttctgtcct cagcatttaa gtcactccag atgtcagatt 3964621 gtaatctcga tcaaatttcc ttcatcatcc tcaatcacgc tttcatagta gccgtctcct 3964681 gttgtcctcg ggccgtttac tactgcgaaa ccatccgcct tcaatcgatc agtcagttcg 3964741 tcaactttct cccggctccc aacggaaaag gcaatatgtg cccagcctgt cattgtttgt 3964801 gagggcggat cggtcacatt cccttttttc ataatttcca gccttgctcc ggaatcaaac 3964861 gtaataaaat aagacttaaa atcttttttc tcattatgat acaaatcatt cgcttcgcca 3964921 ttaaaatacg attcataaaa agacttcatt cgctctaaat cattgaccca gaccgctgta 3964981 tgttcaatct gcatttcttc ctcctccttc gccttcaatg aagttataag gtatgaaatg 3965041 catttcagtt caagcttttt tcttaaattt atgctgaatt ttgatatcag cgggttcatc 3965101 ctgcaaaaat agagaaaatg ctgcgatgcc gagctgctca agattcaaat caagcgacgg 3965161 aaaaccaaga acacggctga tagaagtatt tccctcgcct atgatttcaa catcccaatt 3965221 attctttttg gcaaatagat gaattccagc tgccacttca tcactatttg cataaatagc 3965281 agtcggaacc cgcccgctca tataaaaatg ttcagctgcc agctcaccat cattcatatc 3965341 gttgcatccg gacagcatat ggcggtcttc caaccttccg cagacagctt tataggccgc 3965401 agctttatca gccgtgctcg ggctcctatc agcttctctg acacacgtaa aagcaatatt 3965461 ctcatgcccg cggctcttta aatagcgaaa gctctctgca taagcagttt ttctgtcatt 3965521 aaaagcacaa gggacatcaa tgtctccggt atcctcacaa gcgatgaccg gcccatattc 3965581 ctgataagct aaaatgctgt cccaatgatt ggcgcgggaa gtaatgatga gaccgtctat 3965641 tttcttcgtt cttaacagct ctaaatattt gatttcaata tcggggttat aattggtggg 3965701 gagaagggtc gttgcatact catgctgaaa agccgccttg gtgattccgt taacgatttt 3965761 atcaaagcag ggatgatcgc tataaggcag aatcacaccg accgtatggg ttttcccgcg 3965821 aatgagatcg attgcggttc gatttggtgt ataatccaat tccttcatga cttgatgaac 3965881 aagctttctc ttttcttcag atacatacgg atgatgattc aatacacgcg agacagtcga 3965941 aacagataca tttgccagtc ttgcgatctc ttttatattt gccatctctt tctccttttc 3966001 atataaaaaa agcagtaagt gtaaaatcct tactgctatc tcatcatata ttgatgataa 3966061 gttcaacagg acaatggtcg gaacccatga cgtccgctga tatgctggca tcttcaatct 3966121 gttccttaag gctttcagaa acaacaaaat aatcaatccg ccatccaata tttctgtccc 3966181 gggcgccggc acgatacgac caccaggaat aagcgccttc aagatcagga taaacatgac 3966241 gaaaagaatc aacaaagcca gcttctaaga aacgagtgaa tgcctctctt tcttgatctg 3966301 aaaatccagc gttattccgg ttcgcctttg gatttttcaa gtcaatctcc tgatgggcta 3966361 cattcaaatc accgcataaa atcactggtt ttttctgatc caattcaaga atataagaca 3966421 gtaaagcctc ttcccattgc atgcggtaat caatccgctc taatcccctt ctggaattgg 3966481 gcgtgtaaac agtcatcaca aacacgtttt caaattccag cgtaatcact ctgccttctt 3966541 ggtcatgctc ttctactccg ataccgtaga tgacctgcag cggttcttgc ttagaaaaaa 3966601 cagctgtgcc ggaatatcct tttttcactg cataattcca gtacacatga tagtcttcag 3966661 gctggagatc aacctggccg tcctgtatct tcgtttcctg aagacatata atatctgcat 3966721 cctcttcttt caaataagag aggaaatcca tttttctcat cacagcccgc aggccgttta 3966781 cattccatga aatcaacttc atgtttcatc ctccccccta taaaaaagag caagaacccg 3966841 aaggtccttg ctctttacat atcagcttac tcaccgctta cgtatggaag taaagccatt 3966901 tgacgtgcgc gtttgatcgc tgcagtcaat ttacgttggt atttagcgtt tgttccagtt 3966961 acacgacgtg gtaaaatttt accgcgctca gaaacaaact ttttaagaag atctacatct 3967021 ttgtagtcga tgtgcgtgat accgttagaa gtgaaataac acactttacg gcgtttcgca 3967081 cgaccgcctc tgcgtcctcc tgccattgtc atttccctcc tttctttttc attttaggcg 3967141 ataatcacat tagaatggaa gatcatcatc cgagatgtca atcggtttgc cgtcgttggc 3967201 aaatgggtca tcattaaagc tgttcccctg attgcgtctc tggttgtttt gatttccccc 3967261 aaatggatta tcattttggc ctccgccaaa gtactggcct ccgccgctgt ttccttcgtt 3967321 gtatccacct gaaccagaac cgccgccgtt tttcggctca agaaattgaa cactttcagc 3967381 ttggacctct gtcacgaaga cacgctgtcc ttgctggttt tcatagtttc ttgtttgtaa 3967441 acggccatct acgcctgcaa ggcttccttt tttcaagaag tttgcaacgt tttcggcttg 3967501 tcttctccaa gtgacacaat taatgaaatc ggcctcacgt tctccggact ggttcgtaaa 3967561 tgtacgattc acagcaagag taaacgtagc aacagccgca ccgtttggcg tataacgaag 3967621 ctctgggtct tttgtcagtc ttccgactaa tacaactcgg ttaagcataa gaaagaccac 3967681 cttttaccat tatatatttc aaaattgctt attcttcttc tttaacaaca atgtggcgaa 3967741 tgatatcgtc actgatctta gctagacggt caaattcttg aactgccgca gcgtcagatt 3967801 gaacgtttac gatttggtag aaaccgtcgc ggaaatcgtt gatttcgtaa gcaagacgac 3967861 gtttacccca atcctttgtt ccagtgatct ccgcaccgtt agaagtcaga acgttgttga 3967921 aacgctcgat aactgctttt ttagactctt cgtcaatgtt tgggcggata atgtacataa 3967981 cttcgtactt tctcatctgt ttgcacctcc ttttggacta agcggcccat aatgggcaag 3968041 gagcaataat tctattactc acaattttat attataccaa agctcttgtc cctttacaac 3968101 tgcatcctat acattaaatc ggaaatgaat aacatctccg tcttggacca catattcttt 3968161 cccttcaagg cggacttttc ctgcctcttt agctcctgcc ataccgccgc ccgcaagaag 3968221 atcctcataa gcaactgtct cagcacgaat gaagccccgc tcaaagtcac tatgaataat 3968281 tcctgcacac tcaggggctt tcatgccttt tttgaatgtc caagctctga cttcctgttc 3968341 tccggctgtg aaatatgttg cgaggccgag aagagagtaa gacgctttga tcagctgatc 3968401 aagacctgat tcttgaatgc ccagctcttc caagaacatt tgcttttctt cgccttcaag 3968461 ctcagcgatt tcagattcga tttttgcaca cacaacgata acttctgcgt tttcgccggc 3968521 agcgtactcg cgaatcttcg ctacattttc attgccagat ggatcagcaa cttcatcttc 3968581 acttacgttg gccacgtaca aaataggctt cgaagtcagt aaatggagct gcttcacaag 3968641 cttttgctgc tcttcagtga attctacaga tcgagcaggc ttttcactct caaacgcttc 3968701 tttcagttta gataaaatct caaactcaaa tacagcgtct ttatcttttt gcttcgcaag 3968761 cttgctgacg cgtgtaatcc gcttttcaac tgtttccata tcagcgagga tcagctcaag 3968821 gttgatcgtt tcaatgtcat caatcggatc aacctttccg gaaacgtgtg taatgttgtc 3968881 atcggaaaaa gcacggacaa cgtggcaaat cgcgtcaact tggcgaatat gagataggaa 3968941 cttgttgccg agtccttctc ctttagatgc gccctttaca atccctgcaa tatcagtgaa 3969001 ttcaaaagca gtcggcacag tcttcttcgg gttgaccagc tcagtcagct tttgcagacg 3969061 atcatccggc acctctacaa ttcccacgtt cggatcaatt gtacagaacg ggtagttggc 3969121 tgattcggca ccggcctgtg taattgcgtt aaatagtgtt gattttccga cgttcggcaa 3969181 accaacaatt ccagctgtta aagccattct ttcatctcct ctatataaaa ccgtcattgt 3969241 atgaacgtat tttgaaccta gagcaattat aaggaggttc actggaaaag acaagctgac 3969301 aaaaaagcat tttcagcttg ccaatccctt tgattatgct tttttcaagc ctactaaaca 3969361 gtcaaaaagc gtacttccca ttccattatc agaatttgta tcatttgtca gtgcattgac 3969421 tgaccctcca aaagccgccc acatgccttc atctatatta atcgtcttcg catgagcctg 3969481 cttcatcact ttcaccttgc ccttcatgct tccgcggtca ttaaagatga caacttcgtc 3969541 tccatcctga agatcctgcc cagccgctat atctggagaa atatcgacct gaacgtgctg 3969601 aagcttttca ataaacggca catgctgtga atgattggaa cgctgcggat gaatggataa 3969661 gagcgtataa gggtactttc cagctaactc ctcattatgg aaaacagatt cttcgggcac 3969721 atttaattga agcgagccgc taaatccttt ttgctcagct agcgacgaag taaattcaaa 3969781 ttttccactc ggcgtcaaaa actgataatc atcccacggc acctgtttta ctggaagagg 3969841 gaggtggcct ttttctttta aacgctcaag tgtcacatcc tctgcttcca atgaagaaag 3969901 ccccatctct aaaaattctt gagtgctgta ttcaaacagc tcgccaaacc caagacgttt 3969961 tgcaagctct gaccagatcc agctgtccga tttcgcttca ccctgcggct ccacaagctt 3970021 cttcccgtac tgaacataat gatgatacat actggaatag tagatatctt cttcttcaaa 3970081 aacagtggca gtcggcaaaa cataatcaca cagctctgcg gtatccgtca taatggaatc 3970141 aatcgcgacc gtcattggaa ccttttcaaa tgcttgtctc accttatttg tattcggcac 3970201 ctgagtcagc ggatttccgc acgtcacaat aatcatctca atcgcaggat cagcagcggt 3970261 caacacttct tcagcctgtg tcatcattga aaaagaacgg gatgttgttt ttaattccgg 3970321 cagcgtcagc tttgtttttg caaagctctc accaatctgg acatttccga aattcgcgcc 3970381 gccgccctta attccgacat ttccgcttgc cgccacaagt gcatcaatcc aacgaatcgt 3970441 tcccccgccg tttttatatc gctgcatgcc aagccccata aaagtagaca ccggaccatc 3970501 agcatacaaa cctgccaaat actccagctc ctccatagaa gtttctgttt tcacaataaa 3970561 ctcttccaga gaaacggtct tcaaaagctc tttcacatca tcaaaaccga cagaatgctc 3970621 agaaataaac gtttcatccg ttcttcccat ctcaatcaga accttcaaaa cggctgccgc 3970681 aagccagccg tccattccag gctttacaga gatatagcgg tcggcaagct tagcagtcgg 3970741 gttgaagatc ggatcaatca ccgtaatcgt ggcgcccttc tttttcacct gctgcaagtg 3970801 atggtataag tgcatatttg ttcttgatac atttcttccc cacacaacaa catgcttgct 3970861 gttgtaaata tcaagcggtc cgtgaccgta cgaacggcca aaatcccagc tttgcgcctc 3970921 gataccggag ccccagcata tgcttccgac gatttcggtc acgccgccat atccattaaa 3970981 aaaacgctga tcaagcgctt ttaacagacc gttattcgca taatcatggc tgtgcaaaac 3971041 agcagtcgtc tccgacgttt ccttgatttc ccgaagttta tcggcaattt catcaagtgc 3971101 ctgctcccaa gaaatccgca caaactcgcc attttgtttt ttcattggat agcgaagccg 3971161 atcaggcgaa tttgtttttg tctcaagcat tctgccgcgg ccgcagattt taccttccgt 3971221 aatcggatgg tttggatctc cgtccacttt tgttaccttt ccatcatcaa cagtcaccaa 3971281 aaagccgcag ctgtcccaac aattcagcgg acatgccgac tgatgcactt tgctcatcgc 3971341 cgtcttctcc ttaccttcta tatgaaaaag catgagtgtc ggcctattta tgaagtaggc 3971401 tcctcatgct tgactagtac tttttttagt tttctttcaa attctcttct cggaatcata 3971461 acactgtgag agcatccctc acacttaatt cgaatatcca ttcccatgcg tataattttc 3971521 cagctgttcg ctccgcatgg atgcggtttt ttcatttcta cgatatcatt caggccaaag 3971581 tctttatccg ccaagaccct tcacctcttt tcctaaactg ctgtatctat tgtacaaaaa 3971641 aactgatcat aagagcaatc aagatacccg aaaagaaata catcctctta tttccattta 3971701 ctcaaaatag gatataagag cagacaaact aacaaataca aattgagcat cccatatatc 3971761 ggatacaaga acgcgatcaa atcagaaaat ccgaaagaag taaaaggtac cattaacact 3971821 aacaaaatca acacaatcat ccatctcggc atatgaataa acgccatcag ccggctggac 3971881 aaacccagca aaccagctac cgtcgtcgtg taaatcgcca ggcacagcac cgccgtcata 3971941 cataaaaaaa ggaaataagg cgcaccctcc agaacggcaa acagcggtat ttcaaactga 3972001 gaaagggagc ccgccagctc caccaacgtt tcattataaa caaatgagat cacgccaaaa 3972061 ataagaccgc ttgccacact tgcgattttt gcttctccga gccctttcat ctctttccca 3972121 acagaggata aaatcgcaac aactgaaagg atgtttaaag aggtaaacgt aatgctcgca 3972181 ggccagttat actgctggga caaatcaatc gtccacgtat ggtgatgtgt gctctgaaag 3972241 gagatcagcg catataaaag ccccgctact aacacaggaa tcaaaatact atttatagat 3972301 aatattcctt tcacatccca caaaaacaag cacactgtca cgatgcaaat cagcgtgatt 3972361 ccccaccaga aaggaagctt gtacatttgc agggtcacac cgcctccggc aatcatcacc 3972421 atagtcgtcg aaaacaaata aaaaatgatg aggacatcat aaattttcgc cagccatggc 3972481 cccattaaat gctccagaac cggcagaaaa tgagtggatt gaaccttaaa actgattttc 3972541 atcacaatat aagacgagaa aatgaacata attgtaaaca gcacaatagc aagtccgctt 3972601 tccgccccaa aaaactgcca tatctcctga ccgctcgcat atccggcccc gatcaggctc 3972661 cctaatatga gcagcatcca cttcattccg gctctccaca acactatcac ctcatagaca 3972721 aagttcagct tgttcccgtt attgttacta tataaataaa ggaaagcaaa catgccatat 3972781 tttcatagac atttgaacac aagctgaaat tatcatacga aatacacata aaaaagactg 3972841 ctaatacggc agtctaaaaa gagatattta tttgtttgtc cgcggaatga agaagtgaac 3972901 ttcactcttc acttttttct aaccattcct acctattcaa gtgtttcata agcagaccat 3972961 tgcttgatca tgatcgaggc aatgggggac aatacttgta atcgcccact aaccattcat 3973021 atcatgccct ctactttttt aaaatctctg gtgccataca caaagcataa aaaatcatac 3973081 tgctggatat actgtaaaca accttacata actacacaca ccatagcaat tctgttacct 3973141 actataacaa ggaagtgaaa cccatgaatc gaaaaggcgg gcttttttct tctcaggaac 3973201 gagtaaagca atatgtttca catacagatg ctgcagcggc aaaacaaatc caaaccatcc 3973261 tttcttcatc cttacgtaaa gctgctggca aaccaattgt cgtggtttgt atcggaacag 3973321 accgttcaac cggtgactca ttaggcccgc tcgtaggaat gaaactcaaa cagatgcagc 3973381 tcaccagatt ccatgtctac ggaaccttat ctgaccccgt ccatgctgtg aacatgaagg 3973441 ataaaatcaa tgacattcat aaattacata aaaacccatt tgttatagca gtcgatgcat 3973501 gcttaggccg cgttaagagt gtgggttcat ttcaaatcgg ggacgggcca ttaaagcccg 3973561 gagccggtgt acaaaaagac cttcctgaag tgggagatct tcatattaac ggaatcgtga 3973621 atgtgagcgg ttttatggaa tattttgtat tgcaaaatac tagactcaac ttggtcatga 3973681 atatggcaaa tgttctagcg gaaggtttga gtttaacaga tcggacagag tggaggcaag 3973741 aacgccttaa cccgttgcaa aggctcactg ggcgcatata aaataaaaac catcttcgtt 3973801 tgaaagatgg ttttttcatt tatgattctc gttcagacaa aagctctaaa atccggtcaa 3973861 ggtcttcatt agagaaaaat tcaatttcga ttttgccttt tttcttctgt cttttaatat 3973921 taactgttgt tccaaaataa ttttggagat aggattcccg ttcttttaga accgcatctt 3973981 tcacaggttc ttttttcttt gtttcacgtg gaacattctg attcaactgc tgaatcagct 3974041 gctcaagttg gcgaacattg agctgctccg caatcacttt ttgtaccagc ggttcaagct 3974101 tatttttgtt ttttaagcca agaagcgtgc gtccatgtcc catagaaagc gtgccttcgg 3974161 caataagctg ttgaatattt tctggcagtg tcagcagtct taaatgattc gcaatatgcg 3974221 gtctgctttt cccaagacgt ttggcaagct gctcttgtgt gagatctaag tgtttcaaaa 3974281 gggagtcata tgcctgagcc tcttcaagcg gagataaatc ttcacgctga aggttttcta 3974341 ataaagcaat ttccctcatt aacgcctctg ataattcacg gacaatggcc ggaactgtat 3974401 ctaaacctgc cagctttgcc gctcgaaaac gccgttcacc cgcaacaata tcatagcctt 3974461 ttaaagattt tctgacgata agcggctgaa gaatgccatg ctgcagcaca gattctttta 3974521 gttcagctaa tgcctcgtca tcaaagtgtt ttcttggctg ataaggatta gggcgtaaat 3974581 cggcaatttt aatttcttca actgtctctt cagacaaatc tacctgatta aataacgcat 3974641 taatcccttt tccaaggcct ttagccattc gcagccactt cctttgctaa atctaaatat 3974701 acttccgcac ctcttgaccg cggatcgtat aaaatgatgg gttttccgtg actcggtgcc 3974761 tcactcagac ggacattacg cggaataact gtcttatata ctttatccct aaaatacttt 3974821 ttaacctctt caatcacttg aatgccaagg tttgtccggg catcaagcat tgtcagcaat 3974881 acaccttcaa tcattaaatc agtattcaaa tgcttttgca caagacgtac tgtatttaat 3974941 aactggctga gaccctccaa ggcataatat tcgcactgta caggaatcac aacggaatcc 3975001 gaggcagtaa gggcattaat cgtcagcaag cccaatgacg gcggacaatc aatgataata 3975061 taatcataat tttgctttac tgcttcaagc gctctcttca atctcacttc tcttgatatt 3975121 gtaggaacca gctcgatctc agcccctgca agctgaatcg tcgcaggaat cacatccaag 3975181 ttctctactg tcgttgcttt aataatatct attacatctg catcatctac taaaatatcg 3975241 tacacacact gctctacatc ggctttttca atccctaatc cgcttgtcgc atttccctgc 3975301 ggatcaatat ctaccagcag aacccttttc cctatgtaag ccaaacatgc cccaaggttg 3975361 acagacgtcg ttgttttgcc gaccccgcct ttttggttcg taattgctat gatttttccc 3975421 acgatgtcac ctactttcac atgaacatgt actatcttgc ttctattcta tcaaaaaaag 3975481 attaaagcgt ttcatttttt tcatcatttt gttccgaatc agaagggaaa taattgaaaa 3975541 ttcaagcacg ctttatgctt tctcttataa attctgcaat ttctatgttt ttttgactta 3975601 aaaaaggaat ttcttaaaga aaaaaagaag aagtcacagt acagaacgtg gaaacaggat 3975661 ggtgagaaaa tggtttatca aacgaagaga gatgtacccg ttacgctgat gattgtgttt 3975721 ctcatattac tgatacaagc agatgccatt gttccttttg tgctgggaaa tatgagagtt 3975781 tccggctgga tcatttttat tctgctgact cttttaaatg gactcatcat ttggagcttt 3975841 attgacctaa aatatgtatt gaaggaacac catctgatca ttaaagccgg attgatcaaa 3975901 catcaaattc cttatgaaaa catcgataaa gtcgttcaaa aaaagaaact atggtccggt 3975961 tttcgtctga tcggctctcg ccatgccatc acaatatatt atcagggggg atggggacat 3976021 gcagtaattt caccgcaaaa atctgaagaa tttatccaca agctcaaaga aaagaattct 3976081 aatataataa tattcactaa aagtaagtga ttaccttttg ttaaaaatat aaaaagctct 3976141 cctgcttttc aggagagctt ctattttggt atgcgaatcg ttaattgaat atattcttca 3976201 aattcttctt cttccgtatt caattttaca ccgctgtctt ccaccattga tagtgactgg 3976261 cgaatcgtgt tcatcgcaat tcttgtatct ctgctgaatg ctttgcgtct cggctttggc 3976321 tttctctggc cttgctccag cattttcacc acgcggtctt ctgtctgctt tacatttaaa 3976381 cttttctcaa taatctctgt gagcagtgtg acttggagct caggctgttt cagcggaatc 3976441 agtgctctgg catggcgctc ggtgattttc ttctccataa tcgcctcttg gaccggctga 3976501 ggcagcttta ataaccgaag cttattcgcg attgtagact gcccttttcc taagcgctgt 3976561 gcgagtgcct cctgtgttaa atcatgcagc tcaagcagcc tagcataagc atgcgcttcc 3976621 tcaatagaag acagttcttc ccgctgcaag ttttcgatta acgccacaga agcggtttcc 3976681 gtgtcggaaa aatccttaat aattgccgga atcttttccc actcaagcga ttgcaccgct 3976741 ctccagcgtc tttcacctgc aatgagttcg tattggcctt cttcttctgt atgcctaaca 3976801 acaatcggct gaataatgcc gtgtgtatga atggtcattg ctaactcttt gattttttca 3976861 tctgagaaaa tggtgcgtgg ctgaaaacgg ttgggaacga tagcatttac cggtatttcc 3976921 agaatctctt ctttgtttgt atcatgttca gcaatctccg gctcctgttc cttctcacca 3976981 agcccgaaga aacgagagaa tgaatgcttc atgtacctac accaccttta aaaactgcca 3977041 tttttataat tctattttct catggttttt cctgctgtac atccatcaat tttgatgaaa 3977101 atatgatggt attgtcatat caggctgtct aaattaccct tcaattggcg atttattagg 3977161 agttcccggt tttcttggat acttcttagg tgtatttttt attttgcgta tcaccataat 3977221 attacgatcg ctttcttcaa taggcagctt aaaagaatgg atattctcaa gttctcctcc 3977281 aagcgtcgtg attgcttttt tgcctgcatt cagttcttct tcagctgatg cggcttttaa 3977341 agcaacaaat aaaccgtttt tcttcaccag aggcaagcaa agctcactca aaacagataa 3977401 tctcgcaact gcgcgcgccg tcacaatatc atagctttca cgcacgtctt tccgttgccc 3977461 gaacgtttca gctctgtcat ggcagaatgt tgtattctcc aattgcaaag cttcagacaa 3977521 cttttctaaa aacgtaatcc gtttgtttag tgaatccacg attgtgacat ggaggtgcgg 3977581 aaagcatatt tttatcggca gacttggaaa acccgctccc gctccaacat cacaaatcgt 3977641 gttcacctga ttgaagtcga cataaaaagc agctgtaatg gaatcataaa aatgctttaa 3977701 atacacttct tttttctctg ttattgaagt cagattgatt ttttcgttcc attcaaccag 3977761 catgtcgtaa tacagctcaa attgctccag ctgacgggga gaaagggaga tccctttttc 3977821 cgccaaacca gaagtgaatt cttcaatatt catgccgtca tcctttctac tcggctatct 3977881 tcgcaatgcg tccctgctct aaatacacca atagaattga aatgtccgcc gggtttacac 3977941 cggaaatgcg ggaagcctgg gcaacagaca aaggccgtac atttttcagt ttttgacgcg 3978001 cctcggtcgc aatcccctta attgcgtcat aatcaattcg gtctggaatt tttttatttt 3978061 ccatcttctt cagtttttcc acttgctgaa gagatttttc aatatatcct tcatatttca 3978121 cttggatttc tacttgttct gccacgtctt gaggaaccgg cacttctggc ggcgccagtt 3978181 ttgtgactgt ttcatagttc atttcaggac gtttcatcaa gtctgtgccg cgaactccat 3978241 ctttcaattc gcttccgcca agagaacgga tatattcttg attttccgga gacggcttga 3978301 taattacaga atgaagacgt tttttctccg cctcgatcgc cgcttttttc ttctcaaaag 3978361 ccgcatagcg ctcatcagaa atcaatccaa tgcgatgtcc gatttctgtc agacgcaaat 3978421 cagcattgtc atggcgaagc agcaatctgt attccgcacg tgatgtcaaa agacgatatg 3978481 gctcattggt accttttgtc acaaggtcat caatcagaac accaatatag gcgtcagaac 3978541 ggcttagaat tacttcttct tttccaagcg cttttcgtcc tgcattgatt cccgccataa 3978601 tcccttgtcc cgcagcttct tcataaccgg atgttccgtt aatttggcct gcagtataaa 3978661 ggtttgtgat ttttttggtt tcaagtgtcg gccatagctg tgtcggtacg attgcatcat 3978721 actcgatcgc atagccggct ctcatcattt gcacgttttc aagtccagga atcgttgcaa 3978781 gcattctttg ctgtacgtct tctggaagac ttgtagataa accttggaca tagacttcct 3978841 gtgtatttct gccttccggc tcaaggaaga tttggtgacg cggtttatca ttaaaacgga 3978901 caactttgtc ttcaatggat gggcagtatc ttgggcccgt acctttgatc ataccggaat 3978961 acatcggtga acggtgcagg ttgctgtcaa taatctcatg tgtctcaggg cttgtatatg 3979021 tcagccagca agggagctga tctgtgatat attccactgt ttcatatgag aaagcgcgag 3979081 gcacatcgtc accaggctga atttccgttt tgctgtaatc aatcgtgtcg cttttaacgc 3979141 gaggcggcgt acctgtttta aaacgaacaa ggtcaaaacc gagttcctcc aaatgctcag 3979201 aaagcttaat agaaggctgc tggttattcg ggccgcttga gtaagacaga tcgccaagaa 3979261 tgatacgtcc tcttaaatat gtccctgtcg tcatgacaac tgctttcgca cgataatgtg 3979321 cgcctgtttg tgtaataacg cctcggcatt cgccgtcttc aacgatcagc cgctccacaa 3979381 ttccttgcag caatgttaag tttggttctt tttcaagcgt atttttcatt tcgtgctgat 3979441 attggaattt gtctgcttgc gcacgcaatg cacgaaccgc aggacctttt cctgtattca 3979501 gcattctcat ttgaatatgt gttttatcga tgtttcttcc catttctccg ccgagcgcgt 3979561 caatttcgcg gacgacaatc ccttttgcgg ggccgccgac agacggatta catggcataa 3979621 atgcaaccat atctaggttg atggtcaaga caagcgtttt ggcgccttgg cgtgcagatg 3979681 cgagggcagc ctcaacaccg gcatgcccgg cgccaatcac aatcacatcg tattggcctg 3979741 cttcataccc catgattcta gttcctcctt taattatttt cctaaacaga attgagaaaa 3979801 gagctgatca attaagcttt cgtggacaga atctccaatg atttccccta aaagctccca 3979861 gcatcttgta aggtcaattt gcaccatgtc gatcgggaca tcctgttcga tgccgctaag 3979921 cgcatcttca atggcgcgtt ttgcttgctg taaaatagtg atgtgacgtg tgttgctgac 3979981 ataagtcaga tcaccgcttt caatggcacc cgtgtagaac agtgattgaa tcgcttcttc 3980041 cagatcattg atgccttcct cttttaaaag agatgtcgta acaactggac gtccattggc 3980101 aagctcacgg acacgttcag tgtcaatctt cggctcaagg tcagtcttat tcaaaatcac 3980161 gataacatcc atgccctcaa cggcttcaaa aagcttcacg tcttcttcag aaagctcttc 3980221 actataatta agcacaagta aaatcaggtc cgcttccttt aggacctggc gagaacgttc 3980281 aacaccgatt cgctcaacaa tatcctctgt ttcacgaata cctgctgtat caaccagacg 3980341 aagcggaacg ccccttacat tcacgtattc ctcaatcaca tcccgtgtcg ttccgggaat 3980401 atcggttaca atggcttttg cctcatgaac gaggctgttc agaagagatg attttcctac 3980461 gtttggccgg ccgataatga cggtagaaag accttcacgc aagatttttc cttgctcaga 3980521 agtcctcagc agcgtctcaa tttccttttt cacggcggtt gccttttcga ctaaaatctg 3980581 atgcgtcatt tcctctacat catcatactc cggataatca atattcacct caacatgggc 3980641 cagtgtttct aaaatctcac tgcgcaaacg gcgcaccaaa gcagaaagac gcccttccat 3980701 ttgattcata gcaacgttca ttgcccggtc cgttttcgct ctgattaagt ccataaccgc 3980761 ttccgcctgt gaaagatcga ttcggccgtt taaaaacgca cgtttcgtaa attcaccagg 3980821 ctctgccagt ctcgctccct ctctcaatgc aagctgaagc acttggttca cagtcacaat 3980881 tcccccgtga cagttaatct cgatgacatc ttctcgtgta aaagttctcg gcgcttttaa 3980941 cactgatacc attacttcct caacgacacg atccgaaggt ctgtctacga tatgaccata 3981001 atgaatcgta tgtgattcga ccgagctgag tgttttcccc ttcggtccct tataaatttt 3981061 atctgcgatt tgaatggctt ctggtccgct caaccgtaca atcgcaatcg cgccttctcc 3981121 catcggtgtg gaaattgccg caattgtatc catgttgttc acctctcttt acttatactt 3981181 catctatata aaaaaatttt tattatgcca aaactaaaag ataacatagt ttggttcgaa 3981241 gtggaagatt tgttatccac agaaatagaa attcgtccct tattacttta acttatccac 3981301 atgtgaataa caattaattt tatttcctga acttcctttt tatcaacagg atacacctaa 3981361 aaagaaaaaa cttaaacggc aaaaccttga tattactagg aaaagtagat ttttcggata 3981421 caaaaaaacc gaaatccaat ttttatcgga cttcggtttt atgctatctt ttatgggaaa 3981481 taacgagatg acgattttcg ccttcaccca ttgaatatgt tttgatctgg tggtttgcat 3981541 atccagaaag agtatcgtga ataatttttc tttcgctgga cggcatgggc tcaagctgga 3981601 tggatttttt cgttttcaaa acctggtcag caagcttgat ggccagctgg ctcagtgttt 3981661 cttttctttt caaacgatag ttttctgcat ccaccgtcac atttttatat tggcctggat 3981721 aacggttaag ggcaagctgt gtcaaagttt caagggcgtt taaagtttgt cctcttttcc 3981781 caatcaacaa tgctgccttt tcacctgtta tatgatatct cactgtcttt ttgctttctt 3981841 gaacagtcac atcagacttc ccggcaatgg cttcggcaat cgtttgaaga tataacttcg 3981901 cttgctgaat cggatcaatc ttttcaacca gctttacgat cgcaggcttt ttaccgaaaa 3981961 taccgagaaa ccctttgttt ccctcttcaa taacagtaat ttctacctta tccttcgtta 3982021 atcccaactc ttgcaatccg gactgtactg cttcatcgac atttcgccct gcagcagtca 3982081 cattcctcac tttttctttc ctccggcttt ttgcggctca ggattttttt taatatcagg 3982141 tcctttaatg aggaaagttt gcgcaatcat aaacaagtta ccaactaccc aataaagaga 3982201 aagagccgcc gggaagttga tcgcaaatac gataatcata attggcataa tccaaagcat 3982261 catcgccatt tgcggatttt gctgcgcatt gccagccatc atcagttttt gctgaacaaa 3982321 tgtagcgaca ccggcaacga taggaagaat atagtaagga tctttttctc ctaagtcaaa 3982381 ccataagaag ctatgctctg aaatcgcctg ggttctcatg atcgcatgat agaatccaat 3982441 taaaatcggc atctggatca aaatcgggaa acatcccgcc aatggattga caccatgctt 3982501 ttggaataaa gccattgttt cctgttgaag cttttgctgc gttttttgat cctttgagct 3982561 gtatttttct ttaagctttt gcatttccgg ctgtaaagcc tgcatcgctt tcgaacttct 3982621 cagctgctta atcatcagcg gtaaaattaa taaacgaatt aaaatggtaa ctagaataat 3982681 tgaaagcccg tagttatctc ccgtcaattt cgctacatac gtaatgagct cagacaatgg 3982741 atatactacg tacttgtccc agaaatgcgg actatctgca gtgatcggct ctttcacact 3982801 cgagcatcca gccaaaagca tgaatacgcc aaccatactt aatagcaacc ctattctcct 3982861 tttcaacaac atttcctcct ataattaatc tttacactct tttattgcaa agcatacttg 3982921 tatgtatttt agcatctttc agttttaaat ggtgtctttt tctgatcaac cagaaaggaa 3982981 gcgcttttaa aagttgtaag aaagcagtgg tgatgcctac tttgacgaag atttcttata 3983041 taatgaagac tttctgaata gatgctgcag actttttttc gtttcctcat atgtcagctg 3983101 gctcgccggt tttctggcaa taatgatgta atccttttcc ttcagtctct ctttctcttc 3983161 aagaaaggcc tgccgaatca aacgtttgat ccgatttcgc atcacagcat tgccaatttt 3983221 tttgctgacg gaaagcccga cacgcagttc atcattttca ggctgatcaa gcgtatataa 3983281 gacaaactgg cggtttgcaa ctgatgtccc atgtttaaac actttttgaa aatcttcatt 3983341 tttctttaaa cgatttcgct tcttcaaatg actcactccg atactggctg gcagaaactt 3983401 ttaaaattta ttatgaacat gagatgcatc tgaaccagga agcatgcccc ggttcattac 3983461 gcatcacatc tatcttttcc cataacgtga aaaaagacca ctgacattat tcagtggcct 3983521 aagctgataa tacttttctg cctttgcggc gacggcgtgc taaaactaga cgaccgtttt 3983581 ttgaactcat acggcttctg aagccatgaa ctttgctgcg tttacggtta ttcggttgga 3983641 atgttctttt catttatgac acctccctcg aggaatagct gttaaagaca gtcttactta 3983701 ttatatttgc gttacctatt cattgtcaac ttcactagtg cttttatttc ttgcaaccat 3983761 aataggatac catacctttt caactttcga aaccttattt tttagattcc ttaattttac 3983821 ggaaaaaaga caaattcaaa caatttgccc ctaaaatcac gcatgtggat //